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Sample records for ada language modular

  1. Ada--Programming Language of the Future.

    Science.gov (United States)

    Rudd, David

    1983-01-01

    Ada is a programing language developed for the Department of Defense, with a registered trademark. It was named for Ada Augusta, coworker of Charles Babbage and the world's first programer. The Department of Defense hopes to prevent variations and to establish Ada as a consistent, standardized language. (MNS)

  2. Ada as an implementation language for knowledge based systems

    Science.gov (United States)

    Rochowiak, Daniel

    1990-01-01

    Debates about the selection of programming languages often produce cultural collisions that are not easily resolved. This is especially true in the case of Ada and knowledge based programming. The construction of programming tools provides a desirable alternative for resolving the conflict.

  3. Language constructs for modular parallel programs

    Energy Technology Data Exchange (ETDEWEB)

    Foster, I.

    1996-03-01

    We describe programming language constructs that facilitate the application of modular design techniques in parallel programming. These constructs allow us to isolate resource management and processor scheduling decisions from the specification of individual modules, which can themselves encapsulate design decisions concerned with concurrence, communication, process mapping, and data distribution. This approach permits development of libraries of reusable parallel program components and the reuse of these components in different contexts. In particular, alternative mapping strategies can be explored without modifying other aspects of program logic. We describe how these constructs are incorporated in two practical parallel programming languages, PCN and Fortran M. Compilers have been developed for both languages, allowing experimentation in substantial applications.

  4. Music, Language and Modularity Framed in Action

    Directory of Open Access Journals (Sweden)

    Isabelle Peretz

    2009-06-01

    Full Text Available Here, I examine to what extend music and speech share processing components by focusing on vocal production, that is, singing and speaking. In shaping my review, the modularity concept has been and continues to play a determinant role. Thus, I will first provide a brief background on the contemporary notion of modularity. Next, I will present evidence that musical abilities depend, in part, on modular processes. The evidence is coming mainly from neuropsychological dissociations. The relevance of findings of overlap in neuroimaging, of interference and domain-transfer effects between music and speech will also be addressed and discussed. Finally, I will contrast the modularity position with the resource-sharing framework proposed by Patel (2003, 2008a. This critical review should be viewed as an invitation to undertake future comparative research between music and language by focusing on the details of the functions that these mechanisms carry out, not only their specificity. Such comparative research is very important not only theoretically but also in practice because of their obvious clinical and educational implications.

  5. Modularity, Working Memory, and Second Language Acquisition: A Research Program

    Science.gov (United States)

    Truscott, John

    2017-01-01

    Considerable reason exists to view the mind, and language within it, as modular, and this view has an important place in research and theory in second language acquisition (SLA) and beyond. But it has had very little impact on the study of working memory and its role in SLA. This article considers the need for modular study of working memory,…

  6. Modular Chemical Descriptor Language (MCDL: Stereochemical modules

    Directory of Open Access Journals (Sweden)

    Gakh Andrei A

    2011-01-01

    Full Text Available Abstract Background In our previous papers we introduced the Modular Chemical Descriptor Language (MCDL for providing a linear representation of chemical information. A subsequent development was the MCDL Java Chemical Structure Editor which is capable of drawing chemical structures from linear representations and generating MCDL descriptors from structures. Results In this paper we present MCDL modules and accompanying software that incorporate unique representation of molecular stereochemistry based on Cahn-Ingold-Prelog and Fischer ideas in constructing stereoisomer descriptors. The paper also contains additional discussions regarding canonical representation of stereochemical isomers, and brief algorithm descriptions of the open source LINDES, Java applet, and Open Babel MCDL processing module software packages. Conclusions Testing of the upgraded MCDL Java Chemical Structure Editor on compounds taken from several large and diverse chemical databases demonstrated satisfactory performance for storage and processing of stereochemical information in MCDL format.

  7. An Ada-based preprocessor language for concurrent object oriented programming

    International Nuclear Information System (INIS)

    Almulla, M.; Al-Haddad, M.; Loeper, H.

    2001-01-01

    In this paper, implementation issues of concurrent-objected programming using Ada 95 are addressed. Ada is not a pure object-oriented language; in order to make it so, a uniform template for structuring object classes is proposed. The template constitutes a basis for an Ada-based preprocessor language that handles concurrent object-oriented programming. The preprocessor accepts Ada-like object-oriented programs (object classes, subclasses and main program) as input and produces Ada 95 concurrent object-oriented program units as output. The preprocessor language has the advantage of adding a new component to the class specification called the protocol, which specifies the order for requesting methods f an object. The preprocessor also touches on the extensibility of object classes issue. It supports defining class hierarchies by inheritance and aggregation. In addition, the preprocessor language supports the re-use of Ada packages, which are not necessarily written according to the object-oriented approach. The paper also investigates the definition of circular dependent object classes and proposes a solution for introducing a collection of classes. (author)

  8. Modularity, Working Memory and Language Acquisition

    Science.gov (United States)

    Baddeley, Alan D.

    2017-01-01

    The concept of modularity is used to contrast the approach to working memory proposed by Truscott with the Baddeley and Hitch multicomponent model. This proposes four sub components comprising the "central executive," an executive control system of limited attentional capacity that utilises storage based on separate but interlinked…

  9. Abstraction and Modularization in the BETA Programming Language

    DEFF Research Database (Denmark)

    Madsen, Ole Lehrmann

    2000-01-01

    abstraction mechanisms and lead to a number of new possibilities. Patterns and their instances are intended for modeling concepts and phenomena in the application domain and provide the logical structure of a given system. Modularization is viewed as a means for describing the physical structure of a program....... Modules are units of program text that may be edited, stored in libraries, exist in different variants, be separately compiled, etc. Modularization is provided by a language-independent mechanism based on the context-free grammar of the language. In principle, any correct sequence of terminal...

  10. Modular Domain-Specific Language Components in Scala

    DEFF Research Database (Denmark)

    Hofer, Christian; Ostermann, Klaus

    2010-01-01

    Programs in domain-­specific embedded languages (DSELs) can be represented in the host language in different ways, for instance implicitly as libraries, or explicitly in the form of abstract syntax trees. Each of these representations has its own strengths and weaknesses. The implicit approach ha...... or transformation. We propose a new design for implementing DSELs in Scala which makes it easy to use different program representations at the same time. It enables the DSL implementor to define modular language components and to compose transformations and interpretations for them....

  11. Ada issues in implementing ART-Ada

    Science.gov (United States)

    Lee, S. Daniel

    1990-01-01

    Due to the Ada mandate of a number of government agencies, interest in deploying expert systems such as Ada has increased. Recently, several Ada-based expert system tools have been developed. According to a recent benchmark report, these tools do not perform as well as similar tools written in C. While poorly implemented Ada compilers contribute to the poor benchmark result, some fundamental problems of the Ada language itself have been uncovered. Here, the authors describe Ada language issues encountered during the deployment of ART-Ada, an expert system tool for Ada deployment. ART-Ada is being used to implement several prototype expert systems for the Space Station Freedom and the U.S. Air Force.

  12. First International Conference on Ada (R) Programming Language Applications for the NASA Space Station, volume 1

    Science.gov (United States)

    Bown, Rodney L. (Editor)

    1986-01-01

    Topics discussed include: test and verification; environment issues; distributed Ada issues; life cycle issues; Ada in Europe; management/training issues; common Ada interface set; and run time issues.

  13. Development of Ada language control software for the NASA power management and distribution test bed

    Science.gov (United States)

    Wright, Ted; Mackin, Michael; Gantose, Dave

    1989-01-01

    The Ada language software developed to control the NASA Lewis Research Center's Power Management and Distribution testbed is described. The testbed is a reduced-scale prototype of the electric power system to be used on space station Freedom. It is designed to develop and test hardware and software for a 20-kHz power distribution system. The distributed, multiprocessor, testbed control system has an easy-to-use operator interface with an understandable English-text format. A simple interface for algorithm writers that uses the same commands as the operator interface is provided, encouraging interactive exploration of the system.

  14. Modular code supervisor. Automatic generation of command language

    International Nuclear Information System (INIS)

    Dumas, M.; Thomas, J.B.

    1988-01-01

    It is shown how, starting from a problem formulated by the user, to generate the adequate calculation procedure in the command code, and acquire the data necessary for the calculation while verifying their validity. Modular codes are used, because of their flexibility and wide utilisation. Modules are written in Fortran, and calculations are done in batches according to an algorithm written in the GIBIANE command language. The action plans are based on the STRIPS and WARPLAN families. Elementary representation of a module and special instructions are illustrated. Dynamic construction macro-actions, and acquisition of the specification (which allows users to express the goal of a program without indicating which algorithm is used to reach the goal) are illustrated. The final phase consists in translating the algorithm into the command language [fr

  15. BetaWB - A language for modular representation of biological systems

    DEFF Research Database (Denmark)

    Ihekwaba, Adoha; Larcher, Roberto; Mardare, Radu Iulian

    2007-01-01

    A. Ihekwaba, R. Larcher, R. Mardare, C. Priami. BetaWB - A language for modular representation of biological systems. In Proc. of International Conference on Systems Biology (ICSB), 2007......A. Ihekwaba, R. Larcher, R. Mardare, C. Priami. BetaWB - A language for modular representation of biological systems. In Proc. of International Conference on Systems Biology (ICSB), 2007...

  16. Classic-Ada(TM)

    Science.gov (United States)

    Valley, Lois

    1989-01-01

    The SPS product, Classic-Ada, is a software tool that supports object-oriented Ada programming with powerful inheritance and dynamic binding. Object Oriented Design (OOD) is an easy, natural development paradigm, but it is not supported by Ada. Following the DOD Ada mandate, SPS developed Classic-Ada to provide a tool which supports OOD and implements code in Ada. It consists of a design language, a code generator and a toolset. As a design language, Classic-Ada supports the object-oriented principles of information hiding, data abstraction, dynamic binding, and inheritance. It also supports natural reuse and incremental development through inheritance, code factoring, and Ada, Classic-Ada, dynamic binding and static binding in the same program. Only nine new constructs were added to Ada to provide object-oriented design capabilities. The Classic-Ada code generator translates user application code into fully compliant, ready-to-run, standard Ada. The Classic-Ada toolset is fully supported by SPS and consists of an object generator, a builder, a dictionary manager, and a reporter. Demonstrations of Classic-Ada and the Classic-Ada Browser were given at the workshop.

  17. Transforming AdaPT to Ada

    Science.gov (United States)

    Goldsack, Stephen J.; Holzbach-Valero, A. A.; Waldrop, Raymond S.; Volz, Richard A.

    1991-01-01

    This paper describes how the main features of the proposed Ada language extensions intended to support distribution, and offered as possible solutions for Ada9X can be implemented by transformation into standard Ada83. We start by summarizing the features proposed in a paper (Gargaro et al, 1990) which constitutes the definition of the extensions. For convenience we have called the language in its modified form AdaPT which might be interpreted as Ada with partitions. These features were carefully chosen to provide support for the construction of executable modules for execution in nodes of a network of loosely coupled computers, but flexibly configurable for different network architectures and for recovery following failure, or adapting to mode changes. The intention in their design was to provide extensions which would not impact adversely on the normal use of Ada, and would fit well in style and feel with the existing standard. We begin by summarizing the features introduced in AdaPT.

  18. Evaluation of Rule-based Modularization in Model Transformation Languages illustrated with ATL

    NARCIS (Netherlands)

    Ivanov, Ivan; van den Berg, Klaas; Jouault, Frédéric

    This paper studies ways for modularizing transformation definitions in current rule-based model transformation languages. Two scenarios are shown in which the modular units are identified on the base of the relations between source and target metamodels and on the base of generic transformation

  19. Rule-based modularization in model transformation languages illustrated with ATL

    NARCIS (Netherlands)

    Ivanov, Ivan; van den Berg, Klaas; Jouault, Frédéric

    2007-01-01

    This paper studies ways for modularizing transformation definitions in current rule-based model transformation languages. Two scenarios are shown in which the modular units are identified on the basis of relations between source and target metamodels and on the base of generic transformation

  20. Ada 9X overview

    Science.gov (United States)

    Weller, David G.

    1992-01-01

    The current version of Ada has been an ANSI standard since 1983. In 1988, the Ada Joint Program Office was tasked with reevaluating the language and proposing changes to the standard. Since that time, the world has seen a tremendous explosion in object-oriented languages, as well as other growing fields such as distributed computing and support for very large software systems. The speaker will discuss new features being added to the next version of Ada, currently called Ada 9X, and what transition issues must be considered for current Ada projects.

  1. ADA, the Programming Language of Choice for the UPMSat-2 Satellite

    Science.gov (United States)

    Garrido, Jorge; Zamorano, Juan; de la Puente, Juan A.; Alonso, Alejandro; Salazar, Emilio

    2015-09-01

    The proper selection of development mechanisms and tools is essential for the final success of any engineering project. This is also true when it comes to software development. Furthermore, when the system shows very specific and hard to meet requirements, as it happens for high-integrity real-time systems, the appropriate selection is crucial. For this kind of systems, Ada has proven to be a successful companion, and satellites are not an exception. The paper presents the reasons behind the selection of Ada for the UPMSat-2 development, along with the experience and examples on its usage.

  2. Towards Python-based Domain-specific Languages for Self-reconfigurable Modular Robotics Research

    DEFF Research Database (Denmark)

    Moghadam, Mikael; Christensen, David Johan; Brandt, David

    2011-01-01

    communication, module identification, easy software transfer and reliable module-to-module communication. The end result is a software platform for modular robots that where appropriate builds on existing work in operating systems, virtual machines, middleware and high-level languages....

  3. Ada To X-Window Bindings

    Science.gov (United States)

    Souleles, Dean

    1993-01-01

    Ada to X-Window Bindings computer program developed to provide Ada programmers with complete interfaces to Xt Intrinsics and OSF Motif toolkits. Provides "Ada view" of some mostly C-language programming libraries. Package of software written in Ada and C languages.

  4. ART/Ada and CLIPS/Ada

    Science.gov (United States)

    Culbert, Chris

    1990-01-01

    Although they have reached a point of commercial viability, expert systems were originally developed in artificial intelligence (AI) research environments. Many of the available tools still work best in such environments. These environments typically utilize special hardware such as LISP machines and relatively unfamiliar languages such as LISP or Prolog. Space Station applications will require deep integration of expert system technology with applications developed in conventional languages, specifically Ada. The ability to apply automation to Space Station functions could be greatly enhanced by widespread availability of state-of-the-art expert system tools based on Ada. Although there have been some efforts to examine the use of Ada for AI applications, there are few, if any, existing products which provide state-of-the-art AI capabilities in an Ada tool. The goal of the ART/Ada Design Project is to conduct research into the implementation in Ada of state-of-the-art hybrid expert systems building tools (ESBT's). This project takes the following approach: using the existing design of the ART-IM ESBT as a starting point, analyze the impact of the Ada language and Ada development methodologies on that design; redesign the system in Ada; and analyze its performance. The research project will attempt to achieve a comprehensive understanding of the potential for embedding expert systems in Ada systems for eventual application in future Space Station Freedom projects. During Phase 1 of the project, initial requirements analysis, design, and implementation of the kernel subset of ART-IM functionality was completed. During Phase 2, the effort has been focused on the implementation and performance analysis of several versions with increasing functionality. Since production quality ART/Ada tools will not be available for a considerable time, and additional subtask of this project will be the completion of an Ada version of the CLIPS expert system shell developed by NASA

  5. ART-Ada: An Ada-based expert system tool

    Science.gov (United States)

    Lee, S. Daniel; Allen, Bradley P.

    1991-01-01

    The Department of Defense mandate to standardize on Ada as the language for software systems development has resulted in increased interest in making expert systems technology readily available in Ada environments. NASA's Space Station Freedom is an example of the large Ada software development projects that will require expert systems in the 1990's. Another large scale application that can benefit from Ada based expert system tool technology is the Pilot's Associate (PA) expert system project for military combat aircraft. Automated Reasoning Tool (ART) Ada, an Ada Expert system tool is described. ART-Ada allow applications of a C-based expert system tool called ART-IM to be deployed in various Ada environments. ART-Ada is being used to implement several prototype expert systems for NASA's Space Station Freedom Program and the U.S. Air Force.

  6. Bossa Nova: Introducing modularity into the Bossa Nova domain-specific language

    DEFF Research Database (Denmark)

    Lawall, Julia Laetitia; Duschene, Hervé; Muller, Gilles

    2005-01-01

    subfamilies in using this language to implement an encyclopedic, multi-OS library of scheduling policies. In this paper, we propose that introducing certain kinds of modularity into the language can furnish abstractions appropriate for implementing scheduling policy subfamilies. We present the design of our...... of how to capture these subfamilies in DSL abstractions. A solution should retain features of the original DSL to leverage existing expertise and support tools.   The Bossa DSL is a language targeted towards the development of kernel process scheduling policies. We have encountered the issue of program...

  7. CLIPS/Ada: An Ada-based tool for building expert systems

    Science.gov (United States)

    White, W. A.

    1990-01-01

    Clips/Ada is a production system language and a development environment. It is functionally equivalent to the CLIPS tool. CLIPS/Ada was developed in order to provide a means of incorporating expert system technology into projects where the use of the Ada language had been mandated. A secondary purpose was to glean information about the Ada language and its compilers. Specifically, whether or not the language and compilers were mature enough to support AI applications. The CLIPS/Ada tool is coded entirely in Ada and is designed to be used by Ada systems that require expert reasoning.

  8. Synchronous Modeling of Modular Avionics Architectures using the SIGNAL Language

    OpenAIRE

    Gamatié , Abdoulaye; Gautier , Thierry

    2002-01-01

    This document presents a study on the modeling of architecture components for avionics applications. We consider the avionics standard ARINC 653 specifications as basis, as well as the synchronous language SIGNAL to describe the modeling. A library of APEX object models (partition, process, communication and synchronization services, etc.) has been implemented. This should allow to describe distributed real-time applications using POLYCHRONY, so as to access formal tools and techniques for ar...

  9. Modular specification and verification for higher-order languages with state

    DEFF Research Database (Denmark)

    Svendsen, Kasper

    The overall topic of this thesis is modular reasoning for higher-order languages with state. The thesis consists of four mostly independent chapters that each deal with a different aspect of reasoning about higher-order languages with state. The unifying theme throughout all four chapters is higher....... The third chapter of the thesis is a case study of the C# joins library. What makes this library interesting as a case study is that it combines a lot of advanced features (higher-order code with effects, concurrency, recursion through the store, shared mutable state, and fine-grained synchronization...

  10. Ada Linear-Algebra Program

    Science.gov (United States)

    Klumpp, A. R.; Lawson, C. L.

    1988-01-01

    Routines provided for common scalar, vector, matrix, and quaternion operations. Computer program extends Ada programming language to include linear-algebra capabilities similar to HAS/S programming language. Designed for such avionics applications as software for Space Station.

  11. Modular implicits

    Directory of Open Access Journals (Sweden)

    Leo White

    2015-12-01

    Full Text Available We present modular implicits, an extension to the OCaml language for ad-hoc polymorphism inspired by Scala implicits and modular type classes. Modular implicits are based on type-directed implicit module parameters, and elaborate straightforwardly into OCaml's first-class functors. Basing the design on OCaml's modules leads to a system that naturally supports many features from other languages with systematic ad-hoc overloading, including inheritance, instance constraints, constructor classes and associated types.

  12. Towards Python-based Domain-specific Languages for Self-reconfigurable Modular Robotics Research

    DEFF Research Database (Denmark)

    Moghadam, Mikael; Johan Christensen, David; Brandt, David

    2013-01-01

    This paper explores the role of operating system and high-level languages in the development of software and domain-specific languages (DSLs) for self-reconfigurable robotics. We review some of the current trends in self-reconfigurable robotics and describe the development of a software system...... for ATRON II which utilizes Linux and Python to significantly improve software abstraction and portability while providing some basic features which could prove useful when using Python, either stand-alone or via a DSL, on a self-reconfigurable robot system. These features include transparent socket...... communication, module identification, easy software transfer and reliable module-to-module communication. The end result is a software platform for modular robots that where appropriate builds on existing work in operating systems, virtual machines, middleware and high-level languages....

  13. ART-Ada design project, phase 2

    Science.gov (United States)

    Lee, S. Daniel; Allen, Bradley P.

    1990-01-01

    Interest in deploying expert systems in Ada has increased. An Ada based expert system tool is described called ART-Ada, which was built to support research into the language and methodological issues of expert systems in Ada. ART-Ada allows applications of an existing expert system tool called ART-IM (Automated Reasoning Tool for Information Management) to be deployed in various Ada environments. ART-IM, a C-based expert system tool, is used to generate Ada source code which is compiled and linked with an Ada based inference engine to produce an Ada executable image. ART-Ada is being used to implement several expert systems for NASA's Space Station Freedom Program and the U.S. Air Force.

  14. Ada Namelist Package

    Science.gov (United States)

    Klumpp, Allan R.

    1991-01-01

    Ada Namelist Package, developed for Ada programming language, enables calling program to read and write FORTRAN-style namelist files. Features are: handling of any combination of types defined by user; ability to read vectors, matrices, and slices of vectors and matrices; handling of mismatches between variables in namelist file and those in programmed list of namelist variables; and ability to avoid searching entire input file for each variable. Principle benefits derived by user: ability to read and write namelist-readable files, ability to detect most file errors in initialization phase, and organization keeping number of instantiated units to few packages rather than to many subprograms.

  15. Perceptions Displayed by Novice Programmers When Exploring the Relationship Between Modularization Ability and Performance in the C++ Programming Language

    Science.gov (United States)

    Vodounon, Maurice A.

    2004-01-01

    The primary purpose of this study was to analyze different perceptions displayed by novice programmers in the C++ programming language, and determine if modularization ability could be improved by an instructional treatment that concentrated on solving computer programs from previously existing modules. This study attempted to answer the following…

  16. A Java Chemical Structure Editor Supporting the Modular Chemical Descriptor Language (MCDL

    Directory of Open Access Journals (Sweden)

    Andrei A. Gakh

    2006-03-01

    Full Text Available A compact Modular Chemical Descriptor Language (MCDL chemical structure editor (Java applet is described. The small size (approximately 200 KB of the applet allows its use to display and edit chemical structures in various Internet applications. The editor supports the MCDL format, in which structures are presented in compact canonical form and is capable of restoring bond orders as well as of managing atom and bond drawing overlap. A small database of cage and large cyclic fragment is used for optimal representation of difficult-to-draw molecules. The improved algorithm of the structure diagram generation can be used for other chemical notations that lack atomic coordinates (SMILES, InChI.

  17. Modular Implementation of Programming Languages and a Partial-Order Approach to Infinitary Rewriting

    DEFF Research Database (Denmark)

    Bahr, Patrick

    2012-01-01

    In this dissertation we investigate two independent areas of research. In the first part, we develop techniques for implementing programming languages in a modular fashion. Within this problem domain, we focus on operations on typed abstract syntax trees with the goal of developing a framework...... that facilitates the definition, manipulation and composition of such operations. The result of our work is a comprehensive combinator library that provides these facilities. What sets our approach apart is the use of recursion schemes derived from tree automata in order to implement operations on abstract syntax...... trees. The second part is concerned with infinitary rewriting, a field that studies transfinite rewrite sequences. We extend the established theory of infinitary rewriting in two ways: (1) a novel approach to convergence in infinitary rewriting that replaces convergence in a metric space with the limit...

  18. Knowledge, programming, and programming cultures: LISP, C, and Ada

    Science.gov (United States)

    Rochowiak, Daniel

    1990-01-01

    The results of research 'Ada as an implementation language for knowledge based systems' are presented. The purpose of the research was to compare Ada to other programming languages. The report focuses on the programming languages Ada, C, and Lisp, the programming cultures that surround them, and the programming paradigms they support.

  19. Toward the efficient implementation of expert systems in Ada

    Science.gov (United States)

    Lee, S. Daniel

    1990-01-01

    Here, the authors describe Ada language issues encountered during the development of ART-Ada, an expert system tool for Ada deployment. ART-Ada is being used to implement several expert system applications for the Space Station Freedom and the U.S. Air Force. Additional information is given on dynamic memory allocation.

  20. Study of the Alsys implementation of the Catalogue of Interface Features and Options for the Ada language for 80386 Unix

    Science.gov (United States)

    Gibson, James S.; Barnes, Michael J.; Ostermiller, Daniel L.

    1993-01-01

    A set of programs was written to test the functionality and performance of the Alsys Ada implementation of the Catalogue of Interface Features and Options (CIFO), a set of optional Ada packages for real-time applications. No problems were found with the task id, preemption control, or shared-data packages. Minor problems were found with the dispatching control, dynamic priority, events, non-waiting entry call, semaphore, and scheduling packages. The Alsys implementation is derived mostly from Release 2 of the CIFO standard, but includes some of the features of Release 3 and some modifications unique to Alsys. Performance measurements show that the semaphore and shared-data features are an order-of-magnitude faster than the same mechanisms using an Ada rendezvous. The non-waiting entry call is slightly faster than a standard rendezvous. The existence of errors in the implementation, the incompleteness of the documentation from the published standard impair the usefulness of this implementation. Despite those short-comings, the Alsys CIFO implementation might be of value in the development of real-time applications.

  1. A Comparison of Ada 83 and C++

    Science.gov (United States)

    1991-06-01

    developing large, complex, software systems with long lifetimes. Those interviewed for this study who are familiar with both Ada and C++ believe that Ada is...with those who are familiar with both languages, there was a clear preference for using Ada for large complex systems with long lifetimes. These...University, December 1990 Additions by Nelson H. Weiderman, June 1991. Chile Empresa Nacional de Aeronautica (ENAER), real-time avionics system, Data

  2. An Embedded Rule-Based Diagnostic Expert System in Ada

    Science.gov (United States)

    Jones, Robert E.; Liberman, Eugene M.

    1992-01-01

    Ada is becoming an increasingly popular programming language for large Government-funded software projects. Ada with it portability, transportability, and maintainability lends itself well to today's complex programming environment. In addition, expert systems have also assumed a growing role in providing human-like reasoning capability expertise for computer systems. The integration is discussed of expert system technology with Ada programming language, especially a rule-based expert system using an ART-Ada (Automated Reasoning Tool for Ada) system shell. NASA Lewis was chosen as a beta test site for ART-Ada. The test was conducted by implementing the existing Autonomous Power EXpert System (APEX), a Lisp-based power expert system, in ART-Ada. Three components, the rule-based expert systems, a graphics user interface, and communications software make up SMART-Ada (Systems fault Management with ART-Ada). The rules were written in the ART-Ada development environment and converted to Ada source code. The graphics interface was developed with the Transportable Application Environment (TAE) Plus, which generates Ada source code to control graphics images. SMART-Ada communicates with a remote host to obtain either simulated or real data. The Ada source code generated with ART-Ada, TAE Plus, and communications code was incorporated into an Ada expert system that reads the data from a power distribution test bed, applies the rule to determine a fault, if one exists, and graphically displays it on the screen. The main objective, to conduct a beta test on the ART-Ada rule-based expert system shell, was achieved. The system is operational. New Ada tools will assist in future successful projects. ART-Ada is one such tool and is a viable alternative to the straight Ada code when an application requires a rule-based or knowledge-based approach.

  3. AN ADA NAMELIST PACKAGE

    Science.gov (United States)

    Klumpp, A. R.

    1994-01-01

    The Ada Namelist Package, developed for the Ada programming language, enables a calling program to read and write FORTRAN-style namelist files. A namelist file consists of any number of assignment statements in any order. Features of the Ada Namelist Package are: the handling of any combination of user-defined types; the ability to read vectors, matrices, and slices of vectors and matrices; the handling of mismatches between variables in the namelist file and those in the programmed list of namelist variables; and the ability to avoid searching the entire input file for each variable. The principle user benefits of this software are the following: the ability to write namelist-readable files, the ability to detect most file errors in the initialization phase, a package organization that reduces the number of instantiated units to a few packages rather than to many subprograms, a reduced number of restrictions, and an increased execution speed. The Ada Namelist reads data from an input file into variables declared within a user program. It then writes data from the user program to an output file, printer, or display. The input file contains a sequence of assignment statements in arbitrary order. The output is in namelist-readable form. There is a one-to-one correspondence between namelist I/O statements executed in the user program and variables read or written. Nevertheless, in the input file, mismatches are allowed between assignment statements in the file and the namelist read procedure statements in the user program. The Ada Namelist Package itself is non-generic. However, it has a group of nested generic packages following the nongeneric opening portion. The opening portion declares a variety of useraccessible constants, variables and subprograms. The subprograms are procedures for initializing namelists for reading, reading and writing strings. The subprograms are also functions for analyzing the content of the current dataset and diagnosing errors. Two nested

  4. New control system: IMAGIN supervision in ADA

    International Nuclear Information System (INIS)

    Maugeais, C.

    1991-01-01

    The structure, the initialization, the operating cycle, the different messages and the errors treatment of the new user oriented packages written in ADA language for IMAGIN software are presented. (A.B.). 2 figs

  5. Ada and its impact on the scientific user

    International Nuclear Information System (INIS)

    Marty, R.

    1982-01-01

    The Ada programming language is the result of a collective effort to design a common language for programming real-time systems. The design of Ada was initiated by the United States Department of Defense (DoD) in 1975. Ada combines facilities found in most classical languages like Fortran, PL/I, Pascal, and Basic together with many features formerly found only in experimental languages. It is argued that these features make Ada a very decent tool not only for writing real-time programs but also for the development of software in the scientific sector. (orig.)

  6. Progressive Modularization: Reframing Our Understanding of Typical and Atypical Language Development

    Science.gov (United States)

    D'Souza, Dean; Filippi, Roberto

    2017-01-01

    The ability to acquire language is a critical part of human development. Yet there is no consensus on how the skill emerges in early development. Does it constitute an innately-specified, language-processing module or is it acquired progressively? One of Annette Karmiloff-Smith's (1938-2016) key contributions to developmental science addresses…

  7. Ada in AI or AI in Ada. On developing a rationale for integration

    Science.gov (United States)

    Collard, Philippe E.; Goforth, Andre

    1988-01-01

    The use of Ada as an Artificial Intelligence (AI) language is gaining interest in the NASA Community, i.e., by parties who have a need to deploy Knowledge Based-Systems (KBS) compatible with the use of Ada as the software standard for the Space Station. A fair number of KBS and pseudo-KBS implementations in Ada exist today. Currently, no widely used guidelines exist to compare and evaluate these with one another. The lack of guidelines illustrates a fundamental problem inherent in trying to compare and evaluate implementations of any sort in languages that are procedural or imperative in style, such as Ada, with those in languages that are functional in style, such as Lisp. Discussed are the strengths and weakness of using Ada as an AI language and a preliminary analysis provided of factors needed for the development of criteria for the integration of these two families of languages and the environments in which they are implemented. The intent for developing such criteria is to have a logical rationale that may be used to guide the development of Ada tools and methodology to support KBS requirements, and to identify those AI technology components that may most readily and effectively be deployed in Ada.

  8. Towards a formal semantics for Ada 9X

    Science.gov (United States)

    Guaspari, David; Mchugh, John; Wolfgang, Polak; Saaltink, Mark

    1995-01-01

    The Ada 9X language precision team was formed during the revisions of Ada 83, with the goal of analyzing the proposed design, identifying problems, and suggesting improvements, through the use of mathematical models. This report defines a framework for formally describing Ada 9X, based on Kahn's 'natural semantics', and applies the framework to portions of the language. The proposals for exceptions and optimization freedoms are also analyzed, using a different technique.

  9. Experiences with Ada in an embedded system

    Science.gov (United States)

    Labaugh, Robert J.

    1988-01-01

    Recent experiences with using Ada in a real time environment are described. The application was the control system for an experimental robotic arm. The objectives of the effort were to experiment with developing embedded applications in Ada, evaluating the suitability of the language for the application, and determining the performance of the system. Additional objectives were to develop a control system based on the NASA/NBS Standard Reference Model for Telerobot Control System Architecture (NASREM) in Ada, and to experiment with the control laws and how to incorporate them into the NASREM architecture.

  10. Ada (Trade Name) Bibliography. Volume 3.

    Science.gov (United States)

    1986-02-01

    access to shared resources by concurrently callable procedures. Both rely on queues to achieve serialization, but calls on monitor procedures are...DOCUMENT CITATIONS ADA AS A PROGRAM DESCRIPTION LANGUAGE (PDL): A PROJECT SOFTW ARE MANAGEMENT PERSPECTIVE BOND , RODNEY M. DOCUMENT NUMBER: 6141 TYPE...HONEYWELL BULL-RESEARCH CTR,GRENOBLE,CEDEX,FRANCE 2548 -01 ADA, ABSTRACT DATA TYPES AND DISTRIBUTED DATABASES TRANSACTIONS BOND , RODNEYM., NONAFFILIATED 6141

  11. Modular tree automata

    DEFF Research Database (Denmark)

    Bahr, Patrick

    2012-01-01

    Tree automata are traditionally used to study properties of tree languages and tree transformations. In this paper, we consider tree automata as the basis for modular and extensible recursion schemes. We show, using well-known techniques, how to derive from standard tree automata highly modular...

  12. Languages Beyond Ada and Lisp

    Science.gov (United States)

    1991-08-05

    Shultis: Can you give me one word, or a slogan? Wight: Organized religion ? [Laughter.] Littman: The problem-groping phase. No, that’s not good. Harris: I...valid justification". Wight: This might not be directly related, but these things all fit into, in my mind, the science, or pseudoscience , of the

  13. Defining Modules, Modularity and Modularization

    DEFF Research Database (Denmark)

    Miller, Thomas Dedenroth; Pedersen, Per Erik Elgård

    The paper describes the evolution of the concept of modularity in a historical perspective. The main reasons for modularity are: create variety, utilize similarities, and reduce complexity. The paper defines the terms: Module, modularity, and modularization.......The paper describes the evolution of the concept of modularity in a historical perspective. The main reasons for modularity are: create variety, utilize similarities, and reduce complexity. The paper defines the terms: Module, modularity, and modularization....

  14. Parallel Ada benchmarks for the SVMS

    Science.gov (United States)

    Collard, Philippe E.

    1990-01-01

    The use of parallel processing paradigm to design and develop faster and more reliable computers appear to clearly mark the future of information processing. NASA started the development of such an architecture: the Spaceborne VHSIC Multi-processor System (SVMS). Ada will be one of the languages used to program the SVMS. One of the unique characteristics of Ada is that it supports parallel processing at the language level through the tasking constructs. It is important for the SVMS project team to assess how efficiently the SVMS architecture will be implemented, as well as how efficiently Ada environment will be ported to the SVMS. AUTOCLASS II, a Bayesian classifier written in Common Lisp, was selected as one of the benchmarks for SVMS configurations. The purpose of the R and D effort was to provide the SVMS project team with the version of AUTOCLASS II, written in Ada, that would make use of Ada tasking constructs as much as possible so as to constitute a suitable benchmark. Additionally, a set of programs was developed that would measure Ada tasking efficiency on parallel architectures as well as determine the critical parameters influencing tasking efficiency. All this was designed to provide the SVMS project team with a set of suitable tools in the development of the SVMS architecture.

  15. Object-oriented programming with mixins in Ada

    Science.gov (United States)

    Seidewitz, ED

    1992-01-01

    Recently, I wrote a paper discussing the lack of 'true' object-oriented programming language features in Ada 83, why one might desire them in Ada, and how they might be added in Ada 9X. The approach I took in this paper was to build the new object-oriented features of Ada 9X as much as possible on the basic constructs and philosophy of Ada 83. The object-oriented features proposed for Ada 9X, while different in detail, are based on the same kind of approach. Further consideration of this approach led me on a long reflection on the nature of object-oriented programming and its application to Ada. The results of this reflection, presented in this paper, show how a fairly natural object-oriented style can indeed be developed even in Ada 83. The exercise of developing this style is useful for at least three reasons: (1) it provides a useful style for programming object-oriented applications in Ada 83 until new features become available with Ada 9X; (2) it demystifies many of the mechanisms that seem to be 'magic' in most object-oriented programming languages by making them explicit; and (3) it points out areas that are and are not in need of change in Ada 83 to make object-oriented programming more natural in Ada 9X. In the next four sections I will address in turn the issues of object-oriented classes, mixins, self-reference and supertyping. The presentation is through a sequence of examples. This results in some overlap with that paper, but all the examples in the present paper are written entirely in Ada 83. I will return to considerations for Ada 9X in the last section of the paper.

  16. Software engineering and the role of Ada: Executive seminar

    Science.gov (United States)

    Freedman, Glenn B.

    1987-01-01

    The objective was to introduce the basic terminology and concepts of software engineering and Ada. The life cycle model is reviewed. The application of the goals and principles of software engineering is applied. An introductory understanding of the features of the Ada language is gained. Topics addressed include: the software crises; the mandate of the Space Station Program; software life cycle model; software engineering; and Ada under the software engineering umbrella.

  17. Ada & the Analytical Engine.

    Science.gov (United States)

    Freeman, Elisabeth

    1996-01-01

    Presents a brief history of Ada Byron King, Countess of Lovelace, focusing on her primary role in the development of the Analytical Engine--the world's first computer. Describes the Ada Project (TAP), a centralized World Wide Web site that serves as a clearinghouse for information related to women in computing, and provides a Web address for…

  18. Righting the ADA

    Science.gov (United States)

    National Council on Disability, 2004

    2004-01-01

    Many Americans with disabilities feel that a series of negative court decisions is reducing their status to that of "second-class citizens," a status that the Americans with Disabilities Act (ADA) was supposed to remedy forever. In this report, the National Council on Disability (NCD), which first proposed the enactment of an ADA and…

  19. Evolving impact of Ada on a production software environment

    Science.gov (United States)

    Mcgarry, F.; Esker, L.; Quimby, K.

    1988-01-01

    Many aspects of software development with Ada have evolved as our Ada development environment has matured and personnel have become more experienced in the use of Ada. The Software Engineering Laboratory (SEL) has seen differences in the areas of cost, reliability, reuse, size, and use of Ada features. A first Ada project can be expected to cost about 30 percent more than an equivalent FORTRAN project. However, the SEL has observed significant improvements over time as a development environment progresses to second and third uses of Ada. The reliability of Ada projects is initially similar to what is expected in a mature FORTRAN environment. However, with time, one can expect to gain improvements as experience with the language increases. Reuse is one of the most promising aspects of Ada. The proportion of reusable Ada software on our Ada projects exceeds the proportion of reusable FORTRAN software on our FORTRAN projects. This result was noted fairly early in our Ada projects, and experience shows an increasing trend over time.

  20. Artificial Intelligence in ADA: Pattern-Directed Processing. Final Report.

    Science.gov (United States)

    Reeker, Larry H.; And Others

    To demonstrate to computer programmers that the programming language Ada provides superior facilities for use in artificial intelligence applications, the three papers included in this report investigate the capabilities that exist within Ada for "pattern-directed" programming. The first paper (Larry H. Reeker, Tulane University) is…

  1. Issues Involved in Developing Ada Real-Time Systems

    Science.gov (United States)

    1989-02-15

    expensive modifications to the compiler or Ada runtime system to fit a particular application. Whether we can solve the problems of programming real - time systems in...lock in solutions to problems that are not yet well understood in standards as rigorous as the Ada language. Moreover, real - time systems typically have

  2. Software engineering capability for Ada (GRASP/Ada Tool)

    Science.gov (United States)

    Cross, James H., II

    1995-01-01

    The GRASP/Ada project (Graphical Representations of Algorithms, Structures, and Processes for Ada) has successfully created and prototyped a new algorithmic level graphical representation for Ada software, the Control Structure Diagram (CSD). The primary impetus for creation of the CSD was to improve the comprehension efficiency of Ada software and, as a result, improve reliability and reduce costs. The emphasis has been on the automatic generation of the CSD from Ada PDL or source code to support reverse engineering and maintenance. The CSD has the potential to replace traditional prettyprinted Ada Source code. A new Motif compliant graphical user interface has been developed for the GRASP/Ada prototype.

  3. Monuments on Gemiler Ada and Karacaören Ada

    OpenAIRE

    Masuda, Tomoyuki

    1995-01-01

    Contents : 1. Church I on Gemiler Ada, 2. Church II on Gemiler Ada, 3. Church III on Gemiler Ada, 4. Church IV on Gemiler Ada, 5. Basilica on Karacaören Ada, 6. Painted Tomb on Karacaören Ada, 7. The Baptistery and the Chronology of Construction of the Karacaören Ada Basilica Complex, 8. Ölüdeniz Beach Basilica, 9. Iskender Basilica on Ölüdeniz Lagoon, 10. Mustafa Basilica near Beştaş Cove.

  4. OLDER DRIVERS AND ADAS

    Directory of Open Access Journals (Sweden)

    Ragnhild J. DAVIDSE

    2006-01-01

    Next, based on the available literature, relevant ADAS are discussed in terms of their availability, their effects on safety and the willingness of older drivers to use and buy them. One of the conclusions is that only very few of the types of support that are thought to be most beneficial to the safety of older drivers are provided by the ADAS that are currently available.

  5. Dualisme Modular

    Directory of Open Access Journals (Sweden)

    Natas Setiabudhi Daryono Putra

    2017-09-01

    Full Text Available Dualisme merupakan konsep filsafat yang menyatakan bahwa segala sesuatu memiliki dua hal yang berlawanan atau prinsip. Hidup dan mati, laki dan perempuan, siang dan malam, jiwa dan raga, sehat dan sakit, kaya dan miskin, baik dan buruk, halal dan haram, pro dan kontra, aktif dan pasif, statis dan dinamis, tampan dan buruk rupa, besar dan kecil, panjang dan pendek, manis dan pahit, mahal dan murah, kuat dan lemah, dan seterusnya. Dalam konteks karya ini merupakan representasi dari manusia yang pada dasarnya memiliki 2 kepribadian, baik dan buruk. Keduanya diterjemahkan ke dalam konsep modular dalam menyusun sebuah konfigurasi karya. Pesan yang ingin penulis sampaikan adalah seseorang tidak bisa dinilai dari “baju atau seragam” yang ia pakai. Selain itu keseimbangan dalam baik dan buruk yang direpresentasikan dengan modul positif dan negatif menjadi ambigu dalam kaitan dengan pahala dan dosa dalam Islam. Karya ini meminjam gambar Rubin’s vase/goblet (vas/piala Rubin karya seorang psikolog gestalt Edgar Rubin asal Denmark yang ditransformasi menjadi sebuah karya keramik 3 dimensional [1]. Vas/piala Rubin ini secara perseptual memiliki 2 makna, yaitu gambar vas/piala dan siluet wajah dari samping yang saling berhadapan (pengaruh antarobjek dan latar secara bergiliran. Proses kreasi berasal dari pengalaman empirik personal yang dihubungkan dengan teori-teori pendukung. Perpaduan keduanya menghasilkan karya seni yang merupakan representasi dari realitas. Dalam penciptaan karya seni rupa sebenarnya tidak ada metode baku seperti halnya dalam riset pada umumnya. Proses kreasi kadang berdasarkan intuisi, pengalaman personal yang dominan dan mengandung narasi yang sangat subjektif. Kesemuanya itu dikaitkan dengan disiplin ilmu lainnya (sosial, ekonomi, budaya dan politik untuk menghasilkan sebuah representasi. Modular Dualism Abstract. Dualism is the concept that everything has two opposite sides or principles. Life and death, male and female, day

  6. Techniques and implementation of the embedded rule-based expert system using Ada

    Science.gov (United States)

    Liberman, Eugene M.; Jones, Robert E.

    1991-01-01

    Ada is becoming an increasingly popular programming language for large Government-funded software projects. Ada with its portability, transportability, and maintainability lends itself well to today's complex programming environment. In addition, expert systems have also assured a growing role in providing human-like reasoning capability and expertise for computer systems. The integration of expert system technology with Ada programming language, specifically a rule-based expert system using an ART-Ada (Automated Reasoning Tool for Ada) system shell is discussed. The NASA Lewis Research Center was chosen as a beta test site for ART-Ada. The test was conducted by implementing the existing Autonomous Power EXpert System (APEX), a Lisp-base power expert system, in ART-Ada. Three components, the rule-based expert system, a graphics user interface, and communications software make up SMART-Ada (Systems fault Management with ART-Ada). The main objective, to conduct a beta test on the ART-Ada rule-based expert system shell, was achieved. The system is operational. New Ada tools will assist in future successful projects. ART-Ada is one such tool and is a viable alternative to the straight Ada code when an application requires a rule-based or knowledge-based approach.

  7. SEL Ada reuse analysis and representations

    Science.gov (United States)

    Kester, Rush

    1990-01-01

    Overall, it was revealed that the pattern of Ada reuse has evolved from initial reuse of utility components into reuse of generalized application architectures. Utility components were both domain-independent utilities, such as queues and stacks, and domain-specific utilities, such as those that implement spacecraft orbit and attitude mathematical functions and physics or astronomical models. The level of reuse was significantly increased with the development of a generalized telemetry simulator architecture. The use of Ada generics significantly increased the level of verbatum reuse, which is due to the ability, using Ada generics, to parameterize the aspects of design that are configurable during reuse. A key factor in implementing generalized architectures was the ability to use generic subprogram parameters to tailor parts of the algorithm embedded within the architecture. The use of object oriented design (in which objects model real world entities) significantly improved the modularity for reuse. Encapsulating into packages the data and operations associated with common real world entities creates natural building blocks for reuse.

  8. ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3.

    OpenAIRE

    Horiuchi, J; Silverman, N; Piña, B; Marcus, G A; Guarente, L

    1997-01-01

    The ADA genes encode factors which are proposed to function as transcriptional coactivators. Here we describe the cloning, sequencing, and initial characterization of a novel ADA gene, ADA1. Similar to the previously isolated ada mutants, ada1 mutants display decreases in transcription from various reporters. Furthermore, ADA1 interacts with the other ADAs in the ADA/GCN5 complex as demonstrated by partial purification of the complex and immunoprecipitation experiments. We estimate that the c...

  9. Ada Lovelace Poster

    OpenAIRE

    Charman-Anderson, Suw

    2016-01-01

    Who was Ada Lovelace? What were her greatest achievements? This ‘infoposter’ describes Lovelace’s achievements and describes why she’s thought of as the world’s first computer programmer.Available to buy from RedBubble as a poster, photographic print, art print, framed print, canvas print, metal print, greetings card, spiral bound notebook or hardback journal. 

  10. Formal methods in the design of Ada 1995

    Science.gov (United States)

    Guaspari, David

    1995-01-01

    Formal, mathematical methods are most useful when applied early in the design and implementation of a software system--that, at least, is the familiar refrain. I will report on a modest effort to apply formal methods at the earliest possible stage, namely, in the design of the Ada 95 programming language itself. This talk is an 'experience report' that provides brief case studies illustrating the kinds of problems we worked on, how we approached them, and the extent (if any) to which the results proved useful. It also derives some lessons and suggestions for those undertaking future projects of this kind. Ada 95 is the first revision of the standard for the Ada programming language. The revision began in 1988, when the Ada Joint Programming Office first asked the Ada Board to recommend a plan for revising the Ada standard. The first step in the revision was to solicit criticisms of Ada 83. A set of requirements for the new language standard, based on those criticisms, was published in 1990. A small design team, the Mapping Revision Team (MRT), became exclusively responsible for revising the language standard to satisfy those requirements. The MRT, from Intermetrics, is led by S. Tucker Taft. The work of the MRT was regularly subject to independent review and criticism by a committee of distinguished Reviewers and by several advisory teams--for example, the two User/Implementor teams, each consisting of an industrial user (attempting to make significant use of the new language on a realistic application) and a compiler vendor (undertaking, experimentally, to modify its current implementation in order to provide the necessary new features). One novel decision established the Language Precision Team (LPT), which investigated language proposals from a mathematical point of view. The LPT applied formal mathematical analysis to help improve the design of Ada 95 (e.g., by clarifying the language proposals) and to help promote its acceptance (e.g., by identifying a

  11. Initial Ada components evaluation

    Science.gov (United States)

    Moebes, Travis

    1989-01-01

    The SAIC has the responsibility for independent test and validation of the SSE. They have been using a mathematical functions library package implemented in Ada to test the SSE IV and V process. The library package consists of elementary mathematical functions and is both machine and accuracy independent. The SSE Ada components evaluation includes code complexity metrics based on Halstead's software science metrics and McCabe's measure of cyclomatic complexity. Halstead's metrics are based on the number of operators and operands on a logical unit of code and are compiled from the number of distinct operators, distinct operands, and total number of occurrences of operators and operands. These metrics give an indication of the physical size of a program in terms of operators and operands and are used diagnostically to point to potential problems. McCabe's Cyclomatic Complexity Metrics (CCM) are compiled from flow charts transformed to equivalent directed graphs. The CCM is a measure of the total number of linearly independent paths through the code's control structure. These metrics were computed for the Ada mathematical functions library using Software Automated Verification and Validation (SAVVAS), the SSE IV and V tool. A table with selected results was shown, indicating that most of these routines are of good quality. Thresholds for the Halstead measures indicate poor quality if the length metric exceeds 260 or difficulty is greater than 190. The McCabe CCM indicated a high quality of software products.

  12. Compiling knowledge-based systems from KEE to Ada

    Science.gov (United States)

    Filman, Robert E.; Bock, Conrad; Feldman, Roy

    1990-01-01

    The dominant technology for developing AI applications is to work in a multi-mechanism, integrated, knowledge-based system (KBS) development environment. Unfortunately, systems developed in such environments are inappropriate for delivering many applications - most importantly, they carry the baggage of the entire Lisp environment and are not written in conventional languages. One resolution of this problem would be to compile applications from complex environments to conventional languages. Here the first efforts to develop a system for compiling KBS developed in KEE to Ada (trademark). This system is called KATYDID, for KEE/Ada Translation Yields Development Into Delivery. KATYDID includes early prototypes of a run-time KEE core (object-structure) library module for Ada, and translation mechanisms for knowledge structures, rules, and Lisp code to Ada. Using these tools, part of a simple expert system was compiled (not quite automatically) to run in a purely Ada environment. This experience has given us various insights on Ada as an artificial intelligence programming language, potential solutions of some of the engineering difficulties encountered in early work, and inspiration on future system development.

  13. Service Modularity

    DEFF Research Database (Denmark)

    Avlonitis, Viktor; Hsuan, Juliana

    2015-01-01

    The purpose of this research is to investigate the studies on service modularity with a goal of informing service science and advancing contemporary service systems research. Modularity, a general systems property, can add theoretical underpinnings to the conceptual development of service science...... in general and service systems in particular. Our research is guided by the following question: how can modularity theory inform service system design? We present a review of the modularity literature and associated concepts. We then introduce the contemporary service science and service system discourse...

  14. Modular forms

    NARCIS (Netherlands)

    Edixhoven, B.; van der Geer, G.; Moonen, B.; Edixhoven, B.; van der Geer, G.; Moonen, B.

    2008-01-01

    Modular forms are functions with an enormous amount of symmetry that play a central role in number theory, connecting it with analysis and geometry. They have played a prominent role in mathematics since the 19th century and their study continues to flourish today. Modular forms formed the

  15. ADAS Update and Maintainability

    Science.gov (United States)

    Watson, Leela R.

    2010-01-01

    Since 2000, both the National Weather Service Melbourne (NWS MLB) and the Spaceflight Meteorology Group (SMG) have used a local data integration system (LOIS) as part of their forecast and warning operations. The original LOIS was developed by the Applied Meteorology Unit (AMU) in 1998 (Manobianco and Case 1998) and has undergone subsequent improvements. Each has benefited from three-dimensional (3-D) analyses that are delivered to forecasters every 15 minutes across the peninsula of Florida. The intent is to generate products that enhance short-range weather forecasts issued in support of NWS MLB and SMG operational requirements within East Central Florida. The current LDIS uses the Advanced Regional Prediction System (ARPS) Data Analysis System (AD AS) package as its core, which integrates a wide variety of national, regional, and local observational data sets. It assimilates all available real-time data within its domain and is run at a finer spatial and temporal resolution than current national or regional-scale analysis packages. As such, it provides local forecasters with a more comprehensive understanding of evolving fine-scale weather features. Over the years, the LDIS has become problematic to maintain since it depends on AMU-developed shell scripts that were written for an earlier version of the ADAS software. The goals of this task were to update the NWS MLB/SMG LDIS with the latest version of ADAS, incorporate new sources of observational data, and upgrade and modify the AMU-developed shell scripts written to govern the system. In addition, the previously developed ADAS graphical user interface (GUI) was updated. Operationally, these upgrades will result in more accurate depictions of the current local environment to help with short-range weather forecasting applications, while also offering an improved initialization for local versions of the Weather Research and Forecasting (WRF) model used by both groups.

  16. Specific Language Impairment and High Functioning Autism : Evidence for Distinct Etiologies and for Modularity of Grammar and Pragmatics

    NARCIS (Netherlands)

    Creemers, A.; Schaeffer, J.C.; Perkins, L.; Dudley, R.; Gerard, J.; Hitczenko, K.

    2015-01-01

    This study investigates whether grammar and pragmatics are separate linguistic components, and whether children with Specific Language Impairment (SLI) and children with High Functioning Autism (HFA) have similar or distinct etiologies. A group of 27 children with HFA aged 6-14, age and gender

  17. Modular entanglement.

    Science.gov (United States)

    Gualdi, Giulia; Giampaolo, Salvatore M; Illuminati, Fabrizio

    2011-02-04

    We introduce and discuss the concept of modular entanglement. This is the entanglement that is established between the end points of modular systems composed by sets of interacting moduli of arbitrarily fixed size. We show that end-to-end modular entanglement scales in the thermodynamic limit and rapidly saturates with the number of constituent moduli. We clarify the mechanisms underlying the onset of entanglement between distant and noninteracting quantum systems and its optimization for applications to quantum repeaters and entanglement distribution and sharing.

  18. ARE: Ada Rendering Engine

    Directory of Open Access Journals (Sweden)

    Stefano Penge

    2009-10-01

    Full Text Available E' ormai pratica diffusa, nello sviluppo di applicazioni web, l'utilizzo di template e di potenti template engine per automatizzare la generazione dei contenuti da presentare all'utente. Tuttavia a volte la potenza di tali engine è€ ottenuta mescolando logica e interfaccia, introducendo linguaggi diversi da quelli di descrizione della pagina, o addirittura inventando nuovi linguaggi dedicati.ARE (ADA Rendering Engine è€ pensato per gestire l'intero flusso di creazione del contenuto HTML/XHTML dinamico, la selezione del corretto template, CSS, JavaScript e la produzione dell'output separando completamente logica e interfaccia. I templates utilizzati sono puro HTML senza parti in altri linguaggi, e possono quindi essere gestiti e visualizzati autonomamente. Il codice HTML generato è€ uniforme e parametrizzato.E' composto da due moduli, CORE (Common Output Rendering Engine e ALE (ADA Layout Engine.Il primo (CORE viene utilizzato per la generazione OO degli elementi del DOM ed è pensato per aiutare lo sviluppatore nella produzione di codice valido rispetto al DTD utilizzato. CORE genera automaticamente gli elementi del DOM in base al DTD impostato nella configurazioneIl secondo (ALE viene utilizzato come template engine per selezionare automaticamente in base ad alcuni parametri (modulo, profilo utente, tipologia del nodo, del corso, preferenze di installazione il template HTML, i CSS e i file JavaScript appropriati. ALE permette di usare templates di default e microtemplates ricorsivi per semplificare il lavoro del grafico.I due moduli possono in ogni caso essere utilizzati indipendentemente l'uno dall'altro. E' possibile generare e renderizzare una pagina HTML utilizzando solo CORE oppure inviare gli oggetti CORE al template engine ALE che provvede a renderizzare la pagina HTML. Viceversa è possibile generare HTML senza utilizzare CORE ed inviarlo al template engine ALECORE è alla prima release ed è€ già utilizzato all

  19. Mapping Modular SOS to Rewriting Logic

    DEFF Research Database (Denmark)

    Braga, Christiano de Oliveira; Haeusler, Erik Hermann; Meseguer, José

    Modular SOS (MSOS) is a framework created to improve the modularity of structural operational semantics specifications, a formalism frequently used in the fields of programming languages semantics and process algebras. With the objective of defining formal tools to support the execution and verif......Modular SOS (MSOS) is a framework created to improve the modularity of structural operational semantics specifications, a formalism frequently used in the fields of programming languages semantics and process algebras. With the objective of defining formal tools to support the execution...

  20. Mapping Modular SOS to Rewriting Logic

    DEFF Research Database (Denmark)

    Braga, Christiano de Oliveira; Haeusler, Edward Hermann; Meseguer, José

    2003-01-01

    Modular SOS (MSOS) is a framework created to improve the modularity of structural operational semantics specifications, a formalism frequently used in the fields of programming languages semantics and process algebras. With the objective of defining formal tools to support the execution and verif......Modular SOS (MSOS) is a framework created to improve the modularity of structural operational semantics specifications, a formalism frequently used in the fields of programming languages semantics and process algebras. With the objective of defining formal tools to support the execution...

  1. SDI satellite autonomy using AI and Ada

    Science.gov (United States)

    Fiala, Harvey E.

    1990-01-01

    The use of Artificial Intelligence (AI) and the programming language Ada to help a satellite recover from selected failures that could lead to mission failure are described. An unmanned satellite will have a separate AI subsystem running in parallel with the normal satellite subsystems. A satellite monitoring subsystem (SMS), under the control of a blackboard system, will continuously monitor selected satellite subsystems to become alert to any actual or potential problems. In the case of loss of communications with the earth or the home base, the satellite will go into a survival mode to reestablish communications with the earth. The use of an AI subsystem in this manner would have avoided the tragic loss of the two recent Soviet probes that were sent to investigate the planet Mars and its moons. The blackboard system works in conjunction with an SMS and a reconfiguration control subsystem (RCS). It can be shown to be an effective way for one central control subsystem to monitor and coordinate the activities and loads of many interacting subsystems that may or may not contain redundant and/or fault-tolerant elements. The blackboard system will be coded in Ada using tools such as the ABLE development system and the Ada Production system.

  2. [Event-related brain potentials when Russian verbs being conjugated: to the problem of language processing modularity].

    Science.gov (United States)

    Dan'ko, S G; Boĭtsova, Iu A; Solov'eva, M L; Chernigovskaia, T V; Medvedev, S V

    2014-01-01

    In the light of alternative conceptions of "two-system" and "single-system" models of language processing the efforts have been undertaken to study brain mechanisnis for generation of regular and irregular forms of Russian verbs. The 19 EEG channels of evoked activity were registered along with casual alternations of speech morphology operations to be compared. Verbs of imperfective aspect in the form of an infinitive, belonging either to a group of productive verbs (default, conventionally regular class), or toan unproductive group of verbs (conventionally irregular class) were presented to healthy subjects. The subjects were requested to produce first person present time forms of these verbs. Results of analysis of event related potentials (ERP) for a group of 22 persons are presented. Statistically reliable ERP amplitude distinctions between the verb groups are found onlyin the latencies 600-850 ms in central and parietal zones of the cortex. In these latencies ERP values associated with a presentation of irregular verbs are negative in relation to ERP values associated with the presentation of regular verbs. The received results are interpreted as a consequence of various complexity of mental work with verbs of these different groups and presumably don't support a hypothesis of universality of the "two-system" brain mechanism for processing of the regular and irregular language forms.

  3. Update of GRASP/Ada reverse engineering tools for Ada

    Science.gov (United States)

    Cross, James H., II

    1993-01-01

    The GRASP/Ada project (Graphical Representations of Algorithms, Structures, and Processes for Ada) successfully created and prototyped a new algorithmic level graphical representation for Ada software, the Control Structure Diagram (CSD). The primary impetus for creation of the CSD was to improve the comprehension efficiency of Ada software and, as a result, improve reliability and reduce costs. The emphasis was on the automatic generation of the CSD from Ada PDL or source code to support reverse engineering and maintenance. The CSD has the potential to replace traditional pretty printed Ada source code. In Phase 1 of the GRASP/Ada project, the CSD graphical constructs were created and applied manually to several small Ada programs. A prototype CSD generator (Version 1) was designed and implemented using FLEX and BISON running under VMS on a VAX 11-780. In Phase 2, the prototype was improved and ported to the Sun 4 platform under UNIX. A user interface was designed and partially implemented using the HP widget toolkit and the X Windows System. In Phase 3, the user interface was extensively reworked using the Athena widget toolkit and X Windows. The prototype was applied successfully to numerous Ada programs ranging in size from several hundred to several thousand lines of source code. Following Phase 3,e two update phases were completed. Update'92 focused on the initial analysis of evaluation data collected from software engineering students at Auburn University and the addition of significant enhancements to the user interface. Update'93 (the current update) focused on the statistical analysis of the data collected in the previous update and preparation of Version 3.4 of the prototype for limited distribution to facilitate further evaluation. The current prototype provides the capability for the user to generate CSD's from Ada PDL or source code in a reverse engineering as well as forward engineering mode with a level of flexibility suitable for practical

  4. Ada and the rapid development lifecycle

    Science.gov (United States)

    Deforrest, Lloyd; Gref, Lynn

    1991-01-01

    JPL is under contract, through NASA, with the US Army to develop a state-of-the-art Command Center System for the US European Command (USEUCOM). The Command Center System will receive, process, and integrate force status information from various sources and provide this integrated information to staff officers and decision makers in a format designed to enhance user comprehension and utility. The system is based on distributed workstation class microcomputers, VAX- and SUN-based data servers, and interfaces to existing military mainframe systems and communication networks. JPL is developing the Command Center System utilizing an incremental delivery methodology called the Rapid Development Methodology with adherence to government and industry standards including the UNIX operating system, X Windows, OSF/Motif, and the Ada programming language. Through a combination of software engineering techniques specific to the Ada programming language and the Rapid Development Approach, JPL was able to deliver capability to the military user incrementally, with comparable quality and improved economies of projects developed under more traditional software intensive system implementation methodologies.

  5. GRASP/Ada 95: Reverse Engineering Tools for Ada

    Science.gov (United States)

    Cross, James H., II

    1996-01-01

    The GRASP/Ada project (Graphical Representations of Algorithms, Structures, and Processes for Ada) has successfully created and prototyped an algorithmic level graphical representation for Ada software, the Control Structure Diagram (CSD), and a new visualization for a fine-grained complexity metric called the Complexity Profile Graph (CPG). By synchronizing the CSD and the CPG, the CSD view of control structure, nesting, and source code is directly linked to the corresponding visualization of statement level complexity in the CPG. GRASP has been integrated with GNAT, the GNU Ada 95 Translator to provide a comprehensive graphical user interface and development environment for Ada 95. The user may view, edit, print, and compile source code as a CSD with no discernible addition to storage or computational overhead. The primary impetus for creation of the CSD was to improve the comprehension efficiency of Ada software and, as a result, improve reliability and reduce costs. The emphasis has been on the automatic generation of the CSD from Ada 95 source code to support reverse engineering and maintenance. The CSD has the potential to replace traditional prettyprinted Ada source code. The current update has focused on the design and implementation of a new Motif compliant user interface, and a new CSD generator consisting of a tagger and renderer. The Complexity Profile Graph (CPG) is based on a set of functions that describes the context, content, and the scaling for complexity on a statement by statement basis. When combined graphicafly, the result is a composite profile of complexity for the program unit. Ongoing research includes the development and refinement of the associated functions, and the development of the CPG generator prototype. The current Version 5.0 prototype provides the capability for the user to generate CSDs and CPGs from Ada 95 source code in a reverse engineering as well as forward engineering mode with a level of flexibility suitable for

  6. Modularizing development

    DEFF Research Database (Denmark)

    Müller, Anders Riel; Doucette, Jamie

    a deeper and wider understanding of Korea’s development experience with the hope that Korea’s past can offer lessons for developing countries in search of sustainable and broad‐based development" (KSP 2011). To do so, the KSP provides users with a modularized set of policy narratives that represent Korea...

  7. A Case Study in Modular Programming

    DEFF Research Database (Denmark)

    Christensen, Aske Simon; Midtgaard, Jan; Winther, Johnni

    We report our experience in using two different languages to build the same software project. Specifically, we have converted an entire undergraduate compiler course from using AspectJ, an aspect-oriented language, to using OCaml, a functional language. The course has evolved over a period of eig...... in a modular way....

  8. Modular interpreters with implicit context propagation

    NARCIS (Netherlands)

    P.A. Inostroza Valdera (Pablo); T. van der Storm (Tijs)

    2017-01-01

    textabstractModular interpreters are a crucial first step towards component-based language development: instead of writing language interpreters from scratch, they can be assembled from reusable, semantic building blocks. Unfortunately, traditional language interpreters can be hard to extend because

  9. ADA5/SPT20 links the ADA and SPT genes, which are involved in yeast transcription.

    OpenAIRE

    Marcus, G A; Horiuchi, J; Silverman, N; Guarente, L

    1996-01-01

    In this report we described the cloning and characterization of ADA5, a gene identified by resistance to GAL4-VP16-mediated toxicity. ADA5 binds directly to the VP16 activation domain but not to a transcriptionally defective VP16 double point mutant. Double mutants with mutations in ada5 and other genes (ada2 or ada3) isolated by resistance to GAL4-VP16 grow like ada5 single mutants, suggesting that ADA5 is in the same pathway as the other ADA genes. Further, ADA5 cofractionates and coprecipi...

  10. Multiprocessor performance modeling with ADAS

    Science.gov (United States)

    Hayes, Paul J.; Andrews, Asa M.

    1989-01-01

    A graph managing strategy referred to as the Algorithm to Architecture Mapping Model (ATAMM) appears useful for the time-optimized execution of application algorithm graphs in embedded multiprocessors and for the performance prediction of graph designs. This paper reports the modeling of ATAMM in the Architecture Design and Assessment System (ADAS) to make an independent verification of ATAMM's performance prediction capability and to provide a user framework for the evaluation of arbitrary algorithm graphs. Following an overview of ATAMM and its major functional rules are descriptions of the ADAS model of ATAMM, methods to enter an arbitrary graph into the model, and techniques to analyze the simulation results. The performance of a 7-node graph example is evaluated using the ADAS model and verifies the ATAMM concept by substantiating previously published performance results.

  11. MUSIC, MODULARITY AND SYNTAX

    Directory of Open Access Journals (Sweden)

    Javier Valenzuela

    2007-06-01

    Full Text Available First generation cognitive science has always maintained that the mind/brain is a modular system. This has been especially apparent in linguistics, where the modularity thesis goes largely unquestioned by the linguistic mainstream. Cognitive linguists have long disputed the reality of modular architectures of grammar. Instead of conceiving syntax as a computational system of a relatively small set of formal principles and parameters, cognitive linguists take the notion of grammatical construction to be the basic unit of syntax: syntax is simply our repertoire of form-meaning pairings. On such a view, there is no a-priori reason to believe that semantics and phonology cannot affect syntax. In the present paper, we want to take things a step further and suggest, more generally, that language is not a module of cognition in any strict sense. We present preliminary results from research in progress concerning the effect of music on grammatical constructions. More specifically, our experiment compares reaction times between two grammatical constructions that differ in semantics and intonational curves but share lexical material. Our data so far suggests that subjects take less time reading the construction when the semantic bias and intonation match than in non-matching cases. This, we argue, suggests not only that semantics, phonology and syntax form an information bundle (i.e. a construction in the cognitive linguistic sense, but that perceived similarity of music can influence linguistic cognition.

  12. Metric modular spaces

    CERN Document Server

    Chistyakov, Vyacheslav

    2015-01-01

    Aimed toward researchers and graduate students familiar with elements of functional analysis, linear algebra, and general topology; this book contains a general study of modulars, modular spaces, and metric modular spaces. Modulars may be thought of as generalized velocity fields and serve two important purposes: generate metric spaces in a unified manner and provide a weaker convergence, the modular convergence, whose topology is non-metrizable in general. Metric modular spaces are extensions of metric spaces, metric linear spaces, and classical modular linear spaces. The topics covered include the classification of modulars, metrizability of modular spaces, modular transforms and duality between modular spaces, metric  and modular topologies. Applications illustrated in this book include: the description of superposition operators acting in modular spaces, the existence of regular selections of set-valued mappings, new interpretations of spaces of Lipschitzian and absolutely continuous mappings, the existe...

  13. AN ADA LINEAR ALGEBRA PACKAGE MODELED AFTER HAL/S

    Science.gov (United States)

    Klumpp, A. R.

    1994-01-01

    This package extends the Ada programming language to include linear algebra capabilities similar to those of the HAL/S programming language. The package is designed for avionics applications such as Space Station flight software. In addition to the HAL/S built-in functions, the package incorporates the quaternion functions used in the Shuttle and Galileo projects, and routines from LINPAK that solve systems of equations involving general square matrices. Language conventions in this package follow those of HAL/S to the maximum extent practical and minimize the effort required for writing new avionics software and translating existent software into Ada. Valid numeric types in this package include scalar, vector, matrix, and quaternion declarations. (Quaternions are fourcomponent vectors used in representing motion between two coordinate frames). Single precision and double precision floating point arithmetic is available in addition to the standard double precision integer manipulation. Infix operators are used instead of function calls to define dot products, cross products, quaternion products, and mixed scalar-vector, scalar-matrix, and vector-matrix products. The package contains two generic programs: one for floating point, and one for integer. The actual component type is passed as a formal parameter to the generic linear algebra package. The procedures for solving systems of linear equations defined by general matrices include GEFA, GECO, GESL, and GIDI. The HAL/S functions include ABVAL, UNIT, TRACE, DET, INVERSE, TRANSPOSE, GET, PUT, FETCH, PLACE, and IDENTITY. This package is written in Ada (Version 1.2) for batch execution and is machine independent. The linear algebra software depends on nothing outside the Ada language except for a call to a square root function for floating point scalars (such as SQRT in the DEC VAX MATHLIB library). This program was developed in 1989, and is a copyrighted work with all copyright vested in NASA.

  14. AES Modular Power Systems

    Data.gov (United States)

    National Aeronautics and Space Administration — The AES Modular Power Systems (AMPS) project will demonstrate and infuse modular power electronics, batteries, fuel cells, and autonomous control for exploration...

  15. Modular representation and analysis of fault trees

    Energy Technology Data Exchange (ETDEWEB)

    Olmos, J; Wolf, L [Massachusetts Inst. of Tech., Cambridge (USA). Dept. of Nuclear Engineering

    1978-08-01

    An analytical method to describe fault tree diagrams in terms of their modular compositions is developed. Fault tree structures are characterized by recursively relating the top tree event to all its basic component inputs through a set of equations defining each of the modulus for the fault tree. It is shown that such a modular description is an extremely valuable tool for making a quantitative analysis of fault trees. The modularization methodology has been implemented into the PL-MOD computer code, written in PL/1 language, which is capable of modularizing fault trees containing replicated components and replicated modular gates. PL-MOD in addition can handle mutually exclusive inputs and explicit higher order symmetric (k-out-of-n) gates. The step-by-step modularization of fault trees performed by PL-MOD is demonstrated and it is shown how this procedure is only made possible through an extensive use of the list processing tools available in PL/1. A number of nuclear reactor safety system fault trees were analyzed. PL-MOD performed the modularization and evaluation of the modular occurrence probabilities and Vesely-Fussell importance measures for these systems very efficiently. In particular its execution time for the modularization of a PWR High Pressure Injection System reduced fault tree was 25 times faster than that necessary to generate its equivalent minimal cut-set description using MOCUS, a code considered to be fast by present standards.

  16. Constructing a working taxonomy of functional Ada software components for real-time embedded system applications

    Science.gov (United States)

    Wallace, Robert

    1986-01-01

    A major impediment to a systematic attack on Ada software reusability is the lack of an effective taxonomy for software component functions. The scope of all possible applications of Ada software is considered too great to allow the practical development of a working taxonomy. Instead, for the purposes herein, the scope of Ada software application is limited to device and subsystem control in real-time embedded systems. A functional approach is taken in constructing the taxonomy tree for identified Ada domain. The use of modular software functions as a starting point fits well with the object oriented programming philosophy of Ada. Examples of the types of functions represented within the working taxonomy are real time kernels, interrupt service routines, synchronization and message passing, data conversion, digital filtering and signal conditioning, and device control. The constructed taxonomy is proposed as a framework from which a need analysis can be performed to reveal voids in current Ada real-time embedded programming efforts for Space Station.

  17. The testability of Ada programs

    Science.gov (United States)

    Auty, David; Cohen, Norman H.

    1986-01-01

    Software development for NASA's Space Station poses a significant problem; considered the most difficult by some. The difficulty is the magnitude and complexity of the required software. The concerns raised by consideration of the requirements for testing and checkout procedures for the Space Station software are addressed. In particular, it addresses the use of Ada in the development of widely distributed yet closely coordinated processing.

  18. Formal Semanol Specification of Ada.

    Science.gov (United States)

    1980-09-01

    concurrent task modeling involved very little change to the SEMANOL metalanguage. A primitive capable of initiating concurrent SEMANOL task processors...i.e., #CO-COMPUTE) and two primitivc-; corresponding to integer semaphores (i.c., #P and #V) were all that were required. In addition, these changes... synchronization techniques and choice of correct unblocking alternatives. We should note that it had been our original intention to use the Ada Translator program

  19. Language

    DEFF Research Database (Denmark)

    Sanden, Guro Refsum

    2016-01-01

    Purpose: – The purpose of this paper is to analyse the consequences of globalisation in the area of corporate communication, and investigate how language may be managed as a strategic resource. Design/methodology/approach: – A review of previous studies on the effects of globalisation on corporate...... communication and the implications of language management initiatives in international business. Findings: – Efficient language management can turn language into a strategic resource. Language needs analyses, i.e. linguistic auditing/language check-ups, can be used to determine the language situation...... of a company. Language policies and/or strategies can be used to regulate a company’s internal modes of communication. Language management tools can be deployed to address existing and expected language needs. Continuous feedback from the front line ensures strategic learning and reduces the risk of suboptimal...

  20. Review Article: Yamada, Jeni "Laura: A Case for the Modularity of Language"; Tomasello, Michael "First Verbs: A Case Study of Early Grammatical Development."

    Science.gov (United States)

    Shatz, Marilyn

    1994-01-01

    Jeni Yamada's "Laura" and Michael Tomasello's "First Verbs" continue a tradition of providing useful information on the language ability of individuals in a depth rarely found in multisubject studies; however, these efforts are unusual for case studies in that both take strong theoretical positions on the essence of language and language learning.…

  1. Synthesizing Modular Invariants for Synchronous Code

    Directory of Open Access Journals (Sweden)

    Pierre-Loic Garoche

    2014-12-01

    Full Text Available In this paper, we explore different techniques to synthesize modular invariants for synchronous code encoded as Horn clauses. Modular invariants are a set of formulas that characterizes the validity of predicates. They are very useful for different aspects of analysis, synthesis, testing and program transformation. We describe two techniques to generate modular invariants for code written in the synchronous dataflow language Lustre. The first technique directly encodes the synchronous code in a modular fashion. While in the second technique, we synthesize modular invariants starting from a monolithic invariant. Both techniques, take advantage of analysis techniques based on property-directed reachability. We also describe a technique to minimize the synthesized invariants.

  2. An Evaluation of an Ada Implementation of the Rete Algorithm for Embedded Flight Processors

    Science.gov (United States)

    1990-12-01

    computers was desired. The VAX VMS operating system has many built-in methods for determining program performance (including VAX PCA), but these methods... overviev , of the target environment-- the MIL-STD-1750A VHSIC Avionic Modular Processor ( VA.IP, running under the Ada Avionics Real-Time Software (AARTS... computers . Mil-STD-1750A, the Air Force’s standard flight computer architecture, however, places severe constraints on applications software processing

  3. Modular Interpreters for the Masses: Implicit Context Propagation using Object Algebras

    NARCIS (Netherlands)

    P.A. Inostroza Valdera (Pablo); T. van der Storm (Tijs); C. Kästner (Christian); A. Gokhālé (Aniruddha)

    2015-01-01

    htmlabstractModular interpreters have the potential to achieve component-based language development: instead of writing language interpreters from scratch, they can be assembled from reusable, semantic building blocks. Unfortunately, traditional language interpreters are hard to extend because

  4. Exploring Modularity in Services

    DEFF Research Database (Denmark)

    Avlonitis, Viktor; Hsuan, Juliana

    2017-01-01

    the effects of modularity and integrality on a range of different analytical levels in service architectures. Taking a holistic approach, the authors synthesize and empirically deploy a framework comprised of the three most prevalent themes in modularity and service design literature: Offering (service...... insights on the mirroring hypothesis of modularity theory to services. Originality/value The paper provides a conceptualization of service architectures drawing on service design, modularity, and market relationships. The study enriches service design literature with elements from modularity theory...

  5. Modular robot

    International Nuclear Information System (INIS)

    Ferrante, T.A.

    1997-01-01

    A modular robot may comprise a main body having a structure defined by a plurality of stackable modules. The stackable modules may comprise a manifold, a valve module, and a control module. The manifold may comprise a top surface and a bottom surface having a plurality of fluid passages contained therein, at least one of the plurality of fluid passages terminating in a valve port located on the bottom surface of the manifold. The valve module is removably connected to the manifold and selectively fluidically connects the plurality of fluid passages contained in the manifold to a supply of pressurized fluid and to a vent. The control module is removably connected to the valve module and actuates the valve module to selectively control a flow of pressurized fluid through different ones of the plurality of fluid passages in the manifold. The manifold, valve module, and control module are mounted together in a sandwich-like manner and comprise a main body. A plurality of leg assemblies are removably connected to the main body and are removably fluidically connected to the fluid passages in the manifold so that each of the leg assemblies can be selectively actuated by the flow of pressurized fluid in different ones of the plurality of fluid passages in the manifold. 12 figs

  6. Software tools to aid Pascal and Ada program design

    Energy Technology Data Exchange (ETDEWEB)

    Jankowitz, H.T.

    1987-01-01

    This thesis describes a software tool which analyses the style and structure of Pascal and Ada programs by ensuring that some minimum design requirements are fulfilled. The tool is used in much the same way as a compiler is used to teach students the syntax of a language, only in this case issues related to the design and structure of the program are of paramount importance. The tool operates by analyzing the design and structure of a syntactically correct program, automatically generating a report detailing changes that need to be made in order to ensure that the program is structurally sound. The author discusses how the model gradually evolved from a plagiarism detection system which extracted several measurable characteristics in a program to a model that analyzed the style of Pascal programs. In order to incorporate more-sophistical concepts like data abstraction, information hiding and data protection, this model was then extended to analyze the composition of Ada programs. The Ada model takes full advantage of facilities offered in the language and by using this tool the standard and quality of written programs is raised whilst the fundamental principles of program design are grasped through a process of self-tuition.

  7. Vector-matrix-quaternion, array and arithmetic packages: All HAL/S functions implemented in Ada

    Science.gov (United States)

    Klumpp, Allan R.; Kwong, David D.

    1986-01-01

    The HAL/S avionics programmers have enjoyed a variety of tools built into a language tailored to their special requirements. Ada is designed for a broader group of applications. Rather than providing built-in tools, Ada provides the elements with which users can build their own. Standard avionic packages remain to be developed. These must enable programmers to code in Ada as they have coded in HAL/S. The packages under development at JPL will provide all of the vector-matrix, array, and arithmetic functions described in the HAL/S manuals. In addition, the linear algebra package will provide all of the quaternion functions used in Shuttle steering and Galileo attitude control. Furthermore, using Ada's extensibility, many quaternion functions are being implemented as infix operations; equivalent capabilities were never implemented in HAL/S because doing so would entail modifying the compiler and expanding the language. With these packages, many HAL/S expressions will compile and execute in Ada, unchanged. Others can be converted simply by replacing the implicit HAL/S multiply operator with the Ada *. Errors will be trapped and identified. Input/output will be convenient and readable.

  8. Complexity in Managing Modularization

    DEFF Research Database (Denmark)

    Hansen, Poul H. Kyvsgård; Sun, Hongyi

    2011-01-01

    In general, the phenomenon of managing modularization is not well known. The cause-effect relationships between modularization and realized benefits are complex and comprehensive. Though a number of research works have contributed to the study of the phenomenon of efficient and effective...... modularization management it is far from clarified. Recognizing the need for further empirical research, we have studied 40 modularity cases in various companies. The studies have been designed as long-term studies leaving time for various types of modularization benefits to emerge. Based on these studies we...... have developed a framework to support the heuristic and iterative process of planning and realizing modularization benefits....

  9. Aspects and modular reasoning in nonmonotonic logic

    DEFF Research Database (Denmark)

    Ostermann, Klaus

    2008-01-01

    Nonmonotonic logic is a branch of logic that has been developed to model situations with incomplete information. We argue that there is a connection between AOP and nonmonotonic logic which deserves further study. As a concrete technical contribution and "appetizer", we outline an AO semantics de...... defined in default logic (a form of nonmonotonic logic), propose a definition of modular reasoning, and show that the default logic version of the language semantics admits modular reasoning whereas a conventional language semantics based on weaving does not....

  10. Ada training evaluation and recommendations from the Gamma Ray Observatory Ada Development Team

    International Nuclear Information System (INIS)

    1985-10-01

    The Ada training experiences of the Gamma Ray Observatory Ada development team are related, and recommendations are made concerning future Ada training for software developers. Training methods are evaluated, deficiencies in the training program are noted, and a recommended approach, including course outline, time allocation, and reference materials, is offered

  11. Understanding Socio Technical Modularity

    DEFF Research Database (Denmark)

    Thuesen, Christian Langhoff; Kudsk, Anders; Hvam, Lars

    2011-01-01

    Modularity has gained an increasing popularity as a central concept for exploring product structure, process structure, organization structure and supply chain structure. With the offset in system theory the predominant understanding of modularity however faces difficulties in explaining the social...... dimension of modularity like irrational behaviors, cultural differences, learning processes, social organization and institutional influences on modularity. The paper addresses this gab offering a reinterpretation of the modularity concept from a socio-technical perspective in general and Actor Network...... Theory in particular. By formulating modularity from an ANT perspective covering social, material and process aspects, the modularity of a socio-technical system can be understood as an entanglement of product, process, organizational and institutional modularity. The theoretical framework is illustrated...

  12. System Specification for ADA Integrated Environment Type A AIE(1).

    Science.gov (United States)

    1982-11-12

    includes program library support tools and the linker. The program library is the means by which the AIE supports independent, modular program development...KAPSE TUOL COMMUNICATION Package KAPSE-KAPS ECOMMUNICATION (KAPSE.RTS) (Most of it, except the "Language-Defined Packages" CPC) The overall...including classification of errors by severity; 5. perform optimizations for timing and/or space, without changing the functional meaning of a program by the

  13. Portable modular detection system

    Science.gov (United States)

    Brennan, James S [Rodeo, CA; Singh, Anup [Danville, CA; Throckmorton, Daniel J [Tracy, CA; Stamps, James F [Livermore, CA

    2009-10-13

    Disclosed herein are portable and modular detection devices and systems for detecting electromagnetic radiation, such as fluorescence, from an analyte which comprises at least one optical element removably attached to at least one alignment rail. Also disclosed are modular detection devices and systems having an integrated lock-in amplifier and spatial filter and assay methods using the portable and modular detection devices.

  14. The development of a program analysis environment for Ada: Reverse engineering tools for Ada

    Science.gov (United States)

    Cross, James H., II

    1991-01-01

    The Graphical Representations of Algorithms, Structures, and Processes for Ada (GRASP/Ada) has successfully created and prototyped a new algorithm level graphical representation for Ada software, the Control Structure Diagram (CSD). The primary impetus for creation of the CSD was to improve the comprehension efficiency of Ada software and thus improve reliability and reduce costs. The emphasis was on the automatic generation of the CSD from Ada source code to support reverse engineering and maintenance. The CSD has the potential to replace traditional prettyprinted Ada source code. In Phase 1 of the GRASP/Ada project, the CSD graphical constructs were created and applied manually to several small Ada programs. A prototype (Version 1) was designed and implemented using FLEX and BISON running under the Virtual Memory System (VMS) on a VAX 11-780. In Phase 2, the prototype was improved and ported to the Sun 4 platform under UNIX. A user interface was designed and partially implemented. The prototype was applied successfully to numerous Ada programs ranging in size from several hundred to several thousand lines of source code. In Phase 3 of the project, the prototype was prepared for limited distribution (GRASP/Ada Version 3.0) to facilitate evaluation. The user interface was extensively reworked. The current prototype provides the capability for the user to generate CSD from Ada source code in a reverse engineering mode with a level of flexibility suitable for practical application.

  15. Modularity and Economic Organization

    DEFF Research Database (Denmark)

    Sanchez, Ron; Mahoney, Joseph T.

    This paper addresses modularity as a basis for organizing economic activity. We first define the key concepts of architecture and of modularity as a special form of architecture. We then suggest how modular systems of all types may exhibit several properties of fundamental importance to the organ......This paper addresses modularity as a basis for organizing economic activity. We first define the key concepts of architecture and of modularity as a special form of architecture. We then suggest how modular systems of all types may exhibit several properties of fundamental importance...... to the organization of economic activities, including greater adaptability and evolvability than systems that lack modular properties. We draw extensively on our original 1996 paper on modularity and subsequent research to suggest broad theoretical implications of modularity for (i) firms' product strategies...... markets. We also discuss an evolutionary perspective on modularity as an emergent phenomenon in firms and industries. We explain how modularity as a relatively new field of strategy and economic research may provide a new theoretical perspective on economic organizing that has significant potential...

  16. Product Architecture Modularity Strategies

    DEFF Research Database (Denmark)

    Mikkola, Juliana Hsuan

    2003-01-01

    The focus of this paper is to integrate various perspectives on product architecture modularity into a general framework, and also to propose a way to measure the degree of modularization embedded in product architectures. Various trade-offs between modular and integral product architectures...... and how components and interfaces influence the degree of modularization are considered. In order to gain a better understanding of product architecture modularity as a strategy, a theoretical framework and propositions are drawn from various academic literature sources. Based on the literature review......, the following key elements of product architecture are identified: components (standard and new-to-the-firm), interfaces (standardization and specification), degree of coupling, and substitutability. A mathematical function, termed modularization function, is introduced to measure the degree of modularization...

  17. Modular sequent calculi for classical modal logics

    NARCIS (Netherlands)

    Gilbert, David; Maffezioli, Paolo

    This paper develops sequent calculi for several classical modal logics. Utilizing a polymodal translation of the standard modal language, we are able to establish a base system for the minimal classical modal logic E from which we generate extensions (to include M, C, and N) in a modular manner. Our

  18. Exploring the Relationship between Modularization Ability and Performance in the C++ Programming Language: The Case of Novice Programmers and Expert Programmers

    Science.gov (United States)

    Vodounon, Maurice A.

    2006-01-01

    The primary purpose of the study was to determine if a treatment that concentrates on building programs from previously written modules can improve the decomposition processes of novice programmers in the C++ programming language and, hence, programming performance. For purposes of performance analysis, a subsample of 23 students was divided into…

  19. Ada (Trade Name) Bibliography. Volume 1.

    Science.gov (United States)

    1983-05-01

    GLENN DOCUMENT NUMBER: 3268 TYPE: JOURNAL ARTICLE .5-., SCIENCE VOL 215 ISSUE 34 PP. 775-779S In this article, two principal themes are observed in...AINST LANAN RD NAY 83 ND9S-8-C-936 UNCLASSIFIED F/6 12/5 ML -4.4 ’-4-4----" ’°p..l i . d N N L. 131 t ’ll /II~ Ada Bibliography Volume I 95 𔃾- This...BUDAPEST,HUNGARY 4102 -01 ON THE TYPE CONCEPT OF ADA 6224 -03 UNORTHOGONALITIES IN THE IDENTIFICATION RULES IN ADA BACON, GLENN , IBM SANTA TERESA LABS

  20. Evaluating pleural ADA, ADA2, IFN-γ and IGRA for diagnosing tuberculous pleurisy.

    Science.gov (United States)

    Keng, Li-Ta; Shu, Chin-Chung; Chen, Jason Yao-Ping; Liang, Sheng-Kai; Lin, Ching-Kai; Chang, Lih-Yu; Chang, Chia-Hao; Wang, Jann-Yuan; Yu, Chong-Jen; Lee, Li-Na

    2013-10-01

    Conventional methods for diagnosing tuberculous pleurisy (TB pleurisy) are either invasive or have a long turn-around-time. Performances of pleural adenosine deaminase (ADA), ADA2, interferon-gamma (IFN-γ), and interferon-gamma release assays (IGRA) as diagnostic tools for TB pleurisy were evaluated. Eighty-eight patients with lymphocyte-predominant pleural exudates between June 2010 and March 2011, including 31 with clinically diagnosed TB pleurisy, were prospectively studied. Pleural ADA and ADA2 activity were measured by colorimetric method, IFN-γ levels by enzyme-linked immuno-sorbent assay, and IGRA by enzyme-linked immuno-spot (T-SPOT.TB) assay. Pleural ADA, ADA2, and IFN-γ levels, but not the proportion of positive T-SPOT.TB assay, were significantly higher in patients with TB pleurisy than in those without TB pleurisy. The area under the receiver-operating-characteristic (ROC) curve was 0.920, 0.893, 0.875, and 0.544 for IFN-γ, ADA2, ADA, and T-SPOT.TB assay, respectively. The combination of ADA ≥ 40 IU/L and IFN-γ ≥ 75 pg/mL yielded a specificity of 100%. Pleural ADA, ADA2 and IFN-γ, but not T-SPOT.TB assay, are all sensitive and specific for TB pleurisy. In patients with lymphocyte-predominant pleural exudates, ADA ≥ 40 IU/L and IFN-γ ≥ 75 pg/mL in pleural effusion imply a very high probability of TB pleurisy. Copyright © 2013 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

  1. Service Modularity and Architecture

    DEFF Research Database (Denmark)

    Brax, Saara A.; Bask, Anu; Hsuan, Juliana

    2017-01-01

    , platform-based and mass-customized service business models, comparative research designs, customer perspectives and service experience, performance in context of modular services, empirical evidence of benefits and challenges, architectural innovation in services, modularization in multi-provider contexts......Purpose: Services are highly important in a world economy which has increasingly become service driven. There is a growing need to better understand the possibilities for, and requirements of, designing modular service architectures. The purpose of this paper is to elaborate on the roots...... of the emerging research stream on service modularity, provide a concise overview of existing work on the subject, and outline an agenda for future research on service modularity and architecture. The articles in the special issue offer four diverse sets of research on service modularity and architecture. Design...

  2. Analysis of serum adenosine deaminase (ADA) and ADA1 and ADA2 isoenzyme activities in HIV positive and HIV-HBV co-infected patients.

    Science.gov (United States)

    Khodadadi, Iraj; Abdi, Mohammad; Ahmadi, Abbas; Wahedi, Mohammad Saleh; Menbari, Shahoo; Lahoorpour, Fariba; Rahbari, Rezgar

    2011-08-01

    To determine adenosine deaminase (ADA) activity as a possible diagnostic marker in HIV and HIV-HBV co-infected patients. Blood samples were collected from 72 healthy, 33 HIV positive and 30 HIV-HBV co-infected subjects. Blood CD4+ cell count was recorded and serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total ADA, and ADA1 and ADA2 isoenzyme activities were determined. Serum ALT, AST, total ADA and ADA2 isoenzyme activities were significantly higher in HIV positive and HIV-HBV co-infected groups compare to the control (pADA activities (R(2)=0.589, pADA was significantly increased in HIV and HIV-HBV co-infections. Therefore, because of its low cost and simplicity to perform, ADA activity might be considered as a useful diagnostic tool among the other markers in these diseases. Copyright © 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  3. Ada developers' supplement to the recommended approach

    Science.gov (United States)

    Kester, Rush; Landis, Linda

    1993-01-01

    This document is a collection of guidelines for programmers and managers who are responsible for the development of flight dynamics applications in Ada. It is intended to be used in conjunction with the Recommended Approach to Software Development (SEL-81-305), which describes the software development life cycle, its products, reviews, methods, tools, and measures. The Ada Developers' Supplement provides additional detail on such topics as reuse, object-oriented analysis, and object-oriented design.

  4. ADA members weigh in on critical issues.

    Science.gov (United States)

    Burgess, Karen; Ruesch, Jon D; Mikkelsen, Matthew C; Wagner, Karen Schaid

    2003-01-01

    Science, new technology, patient care, dental reimbursement and government regulations all affect today's dental practitioners. To find out more about how such challenges may affect current private practitioners, the American Dental Association conducted the 2000 Membership Needs and Opinions Survey. A questionnaire was sent to 6,310 ADA members in January 2000 with follow-up mailings in February, March and April 2000. Data collection was completed in July 2000. The survey included questions on critical professional issues, and on perceptions of the ADA and ADA priorities. A total of 3,558 completed surveys were received for an adjusted response rate of 59.5 percent. Members rated the identified issues' level of importance to them. The top three issues included "maintaining my ability to recommend the treatment option I feel is most appropriate for my patients," "receiving fair reimbursement for the dental services I provide," and "protecting myself, my staff and my patients from communicable diseases." New dentists found other items to be more significant to them compared with members overall. Although ADA members as a whole had similar views on critical issues facing dentistry and ADA priorities, there were significant differences regarding some issues. New dentists were far more concerned about securing funds for their practice and paying off debt than were all ADA members. Minority dentists expressed greater levels of concern about certain issues than did all ADA members. When planning and implementing ADA activities, the Association should continue to take into account members' relative rankings of professional issues and note issues of special interest to selected membership subgroups.

  5. Modular Robotic Wearable

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop; Pagliarini, Luigi

    2009-01-01

    In this concept paper we trace the contours and define a new approach to robotic systems, composed of interactive robotic modules which are somehow worn on the body. We label such a field as Modular Robotic Wearable (MRW). We describe how, by using modular robotics for creating wearable....... Finally, by focusing on the intersection of the combination modular robotic systems, wearability, and bodymind we attempt to explore the theoretical characteristics of such approach and exploit the possible playware application fields....

  6. 49 CFR 37.123 - ADA paratransit eligibility: Standards.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false ADA paratransit eligibility: Standards. 37.123... INDIVIDUALS WITH DISABILITIES (ADA) Paratransit as a Complement to Fixed Route Service § 37.123 ADA... complementary paratransit service shall provide the service to the ADA paratransit eligible individuals...

  7. 49 CFR 37.125 - ADA paratransit eligibility: Process.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false ADA paratransit eligibility: Process. 37.125... INDIVIDUALS WITH DISABILITIES (ADA) Paratransit as a Complement to Fixed Route Service § 37.125 ADA... § 37.121 of this part shall establish a process for determining ADA paratransit eligibility. (a) The...

  8. Mapping Modular SOS to Rewriting Logic

    DEFF Research Database (Denmark)

    Braga, Christiano de Oliveira; Haeusler, Edward Hermann; Meseguer, José

    2003-01-01

    and verification of MSOS specifications, we have defined a mapping, named , from MSOS to rewriting logic (RWL), a logic which has been proposed as a logical and semantic framework. We have proven the correctness of and implemented it as a prototype, the MSOS-SL Interpreter, in the Maude system, a high......Modular SOS (MSOS) is a framework created to improve the modularity of structural operational semantics specifications, a formalism frequently used in the fields of programming languages semantics and process algebras. With the objective of defining formal tools to support the execution...

  9. Ada Compiler Validation Summary Report: Certificate Number: 940325S1. 11352 DDC-I DACS Sun SPARC/Solaries to Pentium PM Bare Ada Cross Compiler System, Version 4.6.4 Sun SPARCclassic = Intel Pentium (Operated as Bare Machine) Based in Xpress Desktop (Intel Product Number: XBASE6E4F-B)

    Science.gov (United States)

    1994-03-25

    Best Available Copy REPORT DOCUMENTATION PAGE _V -ONC Uft Xaf. WO -" Am u~~ ns~ 940325SI. 11352 , AVV: 94ddc5OO_3d. Compiler: DACS Sun SPARC/ aonais to...Manual for the Ada Proarammina Language, ANSI/MIL-STD-1815A, February 1983 and ISO 8652-1987. [Pro92] Ada Coupiler Validation Procedures, Version 3.1...objectives found to be irrelevant for the given Ada implementation. ISO International Organization for Standardization. LRM The Ada standard, or

  10. Modularization and Flexibilization.

    Science.gov (United States)

    Van Meel, R. M.

    Publications in the fields of educational science, organization theory, and project management were analyzed to identify the possibilities that modularization offers to institutions of higher professional education and to obtain background information for use in developing a method for modularization in higher professional education. It was…

  11. Implementing Modular A Levels.

    Science.gov (United States)

    Holding, Gordon

    This document, which is designed for curriculum managers at British further education (FE) colleges, presents basic information on the implementation and perceived benefits of the General Certificate of Education (GCE) modular A (Advanced) levels. The information was synthesized from a survey of 12 FE colleges that introduced the modular A levels…

  12. Evaluating rivastigmine in mild-to-moderate Parkinson's disease dementia using ADAS-cog items.

    Science.gov (United States)

    Schmitt, Frederick A; Aarsland, Dag; Brønnick, Kolbjørn S; Meng, Xiangyi; Tekin, Sibel; Olin, Jason T

    2010-08-01

    Rivastigmine has been shown to improve cognition in patients with Parkinson's disease dementia (PDD). To further explore the impact of anticholinesterase therapy on PDD, Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) items were assessed in a retrospective analysis of a 24-week, double-blind, placebo-controlled trial of rivastigmine. Mean changes from baseline at week 24 were calculated for ADAS-cog item scores and for 3 cognitive domain scores. A total of 362 patients were randomized to 3 to 12 mg/d rivastigmine capsules and 179 to placebo. Patients with PDD receiving rivastigmine improved versus placebo on items: word recall, following commands, ideational praxis, remembering test instructions, and comprehension of spoken language (P ADAS-cog is sensitive to broad cognitive changes in PDD. Overall, rivastigmine was associated with improvements on individual cognitive items and general cognitive domains.

  13. Ada Run Time Support Environments and a common APSE Interface Set. [Ada Programming Support Environment

    Science.gov (United States)

    Mckay, C. W.; Bown, R. L.

    1985-01-01

    The paper discusses the importance of linking Ada Run Time Support Environments to the Common Ada Programming Support Environment (APSE) Interface Set (CAIS). A non-stop network operating systems scenario is presented to serve as a forum for identifying the important issues. The network operating system exemplifies the issues involved in the NASA Space Station data management system.

  14. Proposal of 'Modular Heliotron'

    International Nuclear Information System (INIS)

    Yamazaki, Kozo

    1994-01-01

    A new modular helical system named 'Modular Heliotron' with clean and efficient helical magnetic divertor is proposed as an extension of the present conventional design of the continuous helical coil system. The sectored helical coils on one plane of the torus and the sectored returning vertical field coils on the other plane are combined. This coil system produces magnetic surfaces nearly equivalent to those of the l=2 helical system with one-pair poloidal coils, and overcomes the defects of construction and maintenance difficulties of the continuous coil systems. This concept satisfies the compatibility between the coil modularity and the sufficient divertor-space utilization, different from previous modular coil designs. The allowable length of the gap between each modular coil is clarified to keep good magnetic surfaces. Typical examples of the reactor coil configuration are described as an extension of the LHD (Large Helical Device) configuration. (author)

  15. Evolution of Modularity Literature

    DEFF Research Database (Denmark)

    Frandsen, Thomas

    2017-01-01

    Purpose The purpose of this paper is to review and analyze the modularity literature to identify the established and emerging perspectives. Design/methodology/approach A systematic literature search and review was conducted through the use of bibliometrics and network analysis. The analysis...... identified structure within the literature, which revealed how the research area evolved between 1990 and 2015. Based on this search, the paper establishes the basis for analyzing the structure of modularity literature. Findings Factors were identified within the literature, demonstrating how it has evolved...... from a primary focus on the modularity of products to a broader view of the applicability of modularity. Within the last decade, numerous research areas have emerged within the broader area of modularity. Through core-periphery analysis, eight emerging sub-research areas are identified, of which one...

  16. Designing Modular Robotic Playware

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop; Marti, Patrizia

    2009-01-01

    In this paper, we explore the design of modular robotic objects that may enhance playful experiences. The approach builds upon the development of modular robotics to create a kind of playware, which is flexible in both set-up and activity building for the end-user to allow easy creation of games....... Key features of this design approach are modularity, flexibility, and construction, immediate feedback to stimulate engagement, activity design by end-users, and creative exploration of play activities. These features permit the use of such modular playware by a vast array of users, including disabled...... children who often could be prevented from using and taking benefits from modern technologies. The objective is to get any children moving, exchanging, experimenting and having fun, regardless of their cognitive or physical ability levels. The paper describes two prototype systems developed as modular...

  17. Proposal of 'modular heliotron'

    International Nuclear Information System (INIS)

    Yamazaki, Kozo.

    1993-11-01

    A new modular helical configuration named 'Modular Heliotron' with clean and efficient helical magnetic divertor is proposed as an extension of the present conventional design of the continuous helical coil system. The sectored helical coils on one plane of the torus and the sectored returning vertical field coils on the other plane are combined. This coil system produces magnetic surfaces nearly equivalent to those of the l=2 helical system with one-pair poloidal coils, and overcomes the defects of construction and maintenance difficulties of the continuous coil systems. This concept satisfies the compatibility between the coil modularity and the sufficient divertor-space utilization, different from previous modular coil designs. The allowable length of the gap between each modular coil is clarified to keep good magnetic surfaces. Typical examples of the reactor coil configuration are described as an extension of the LHD (Large Helical Device) configuration. (author)

  18. A modular optical sensor

    Science.gov (United States)

    Conklin, John Albert

    This dissertation presents the design of a modular, fiber-optic sensor and the results obtained from testing the modular sensor. The modular fiber-optic sensor is constructed in such manner that the sensor diaphragm can be replaced with different configurations to detect numerous physical phenomena. Additionally, different fiber-optic detection systems can be attached to the sensor. Initially, the modular sensor was developed to be used by university of students to investigate realistic optical sensors and detection systems to prepare for advance studies of micro-optical mechanical systems (MOMS). The design accomplishes this by doing two things. First, the design significantly lowers the costs associated with studying optical sensors by modularizing the sensor design. Second, the sensor broadens the number of physical phenomena that students can apply optical sensing techniques to in a fiber optics sensor course. The dissertation is divided into seven chapters covering the historical development of fiber-optic sensors, a theoretical overview of fiber-optic sensors, the design, fabrication, and the testing of the modular sensor developed in the course of this work. Chapter 1 discusses, in detail, how this dissertation is organized and states the purpose of the dissertation. Chapter 2 presents an historical overview of the development of optical fibers, optical pressure sensors, and fibers, optical pressure sensors, and optical microphones. Chapter 3 reviews the theory of multi-fiber optic detection systems, optical microphones, and pressure sensors. Chapter 4 presents the design details of the modular, optical sensor. Chapter 5 delves into how the modular sensor is fabricated and how the detection systems are constructed. Chapter 6 presents the data collected from the microphone and pressure sensor configurations of the modular sensor. Finally, Chapter 7 discusses the data collected and draws conclusions about the design based on the data collected. Chapter 7 also

  19. ADASAGE, ADA Application Development System

    International Nuclear Information System (INIS)

    Taylor, M.; Russell, K.; Stewart, H.

    2001-01-01

    1 - Description of program or function: ADASAGE is an application development system designed to facilitate rapid and professional construction of applications written in Ada on microcomputers. ADASAGE applications may vary in size from small to large multi-program systems. ADASAGE consists of a collection of re-usable libraries for database management and form and report processing utilities having the following capabilities: basic universal type and function definitions; sequential file input/output; terminal and file input/output; DOS system command execution; data movement and fill; string manipulation; math libraries; bit manipulation; a relational database utility; data validation; menu form and window procedures; report generation; sort/merge, time, and date functions; sound production; editing; and index rebuilding. Each of the capabilities is integrated to allow the development of an efficient system. As an application is designed and developed, the desired ADASAGE capabilities are chosen and included along with any requirements unique to that application. 2 - Method of solution: All ADASAGE applications which use the database, forms (windows, menus, etc.), or reporting functions require a file with a suffix of .DFL. This file contains the database schema, the various forms and windows, and report definitions. The THOR editor is used to create and maintain the .DFL file. This editor operates on a file with the suffix .SRC and creates and edits schemes, forms, and report formats and compile the .SRC file into the .DFL file used by the application. The application will have unique requirements not satisfied by the selected utilities of ADASAGE. The code for these along with the code necessary to import and use the selected ADASAGE utilities constitutes the p rogrammed application . The completed application system will contain the .DFL file produced by the THOR editor, the required ADASAGE utilities, and the programmed application. During the course of

  20. Atomic Data and Modelling for Fusion: the ADAS Project

    International Nuclear Information System (INIS)

    Summers, H. P.; O'Mullane, M. G.

    2011-01-01

    The paper is an update on the Atomic Data and Analysis Structure, ADAS, since ICAM-DATA06 and a forward look to its evolution in the next five years. ADAS is an international project supporting principally magnetic confinement fusion research. It has participant laboratories throughout the world, including ITER and all its partner countries. In parallel with ADAS, the ADAS-EU Project provides enhanced support for fusion research at Associated Laboratories and Universities in Europe and ITER. OPEN-ADAS, sponsored jointly by the ADAS Project and IAEA, is the mechanism for open access to principal ADAS atomic data classes and facilitating software for their use. EXTENDED-ADAS comprises a variety of special, integrated application software, beyond the purely atomic bounds of ADAS, tuned closely to specific diagnostic analyses and plasma models.The current scientific content and scope of these various ADAS and ADAS related activities are briefly reviewed. These span a number of themes including heavy element spectroscopy and models, charge exchange spectroscopy, beam emission spectroscopy and special features which provide a broad baseline of atomic modelling and support. Emphasis will be placed on 'lifting the fundamental data baseline'--a principal ADAS task for the next few years. This will include discussion of ADAS and ADAS-EU coordinated and shared activities and some of the methods being exploited.

  1. Ada in Introductory Computer Science Courses

    Science.gov (United States)

    1993-01-01

    M2 111418111 1111111 I s%1 tems to des elop soaftware Systems for IM5. ONhalt oIf dt ufl’wae mownev b f "bs" arn .exti to k ,ulift la Ada. COMPUT...beftjobamdsodeckldthesespienicngamnug them. A celula 101110011ui systm Service in Ada& using an rmniticdawau dipay shows *I tatus. The systm objweaniiimd...liftt aftr of Fucal Nikkao Wirh. Some say Software i - , I, ced a pse-validaed ver. origina soitweim is coded. The idWa is to that Ads is the las gpat

  2. Gamma ray observatory dynamics simulator in Ada (GRODY)

    International Nuclear Information System (INIS)

    1990-09-01

    This experiment involved the parallel development of dynamics simulators for the Gamma Ray Observatory in both FORTRAN and Ada for the purpose of evaluating the applicability of Ada to the NASA/Goddard Space Flight Center's flight dynamics environment. The experiment successfully demonstrated that Ada is a viable, valuable technology for use in this environment. In addition to building a simulator, the Ada team evaluated training approaches, developed an Ada methodology appropriate to the flight dynamics environment, and established a baseline for evaluating future Ada projects

  3. Modularity analysis of automotive control software

    OpenAIRE

    Dajsuren, Y.; Brand, van den, M.G.J.; Serebrenik, A.

    2013-01-01

    A design language and tool like MATLAB/Simulink is used for the graphical modelling and simulation of automotive control software. As the functionality based on electronics and software systems increases in motor vehicles, it is becoming increasingly important for system/software architects and control engineers in the automotive industry to ensure the quality of the highly complex MATLAB/Simulink control software. For automotive software, modularity is recognized as being a crucial quality a...

  4. Modular Lego-Electronics

    KAUST Repository

    Shaikh, Sohail F.; Ghoneim, Mohamed T.; Bahabry, Rabab R.; Khan, Sherjeel M.; Hussain, Muhammad Mustafa

    2017-01-01

    . Here, a generic manufacturable method of converting state-of-the-art complementary metal oxide semiconductor-based ICs into modular Lego-electronics is shown with unique geometry that is physically identifiable to ease manufacturing and enhance

  5. A modular control system

    International Nuclear Information System (INIS)

    Cruz, B.; Drexler, J.; Olcese, G.; Santome, D.

    1990-01-01

    The main objective of the modular control system is to provide the requirements to most of the processes supervision and control applications within the industrial automatization area. The design is based on distribution, modulation and expansion concepts. (Author) [es

  6. DESCRIPCIÓN MODULAR DE UN ESQUEMA DE CODIFICACIÓN CONCATENADO PARA CORRECCIÓN DE ERRORES CON PROGRAMACIÓN DE HARDWARE MODULAR DESIGN OF SCHEME CODING CONCATENATED FOR CORRECTION ERROR WITH PROGRAMMING OF HARDWARE

    Directory of Open Access Journals (Sweden)

    Cecilia E Sandoval Ruiz

    2008-09-01

    Full Text Available Las comunicaciones inalámbricas requieren el empleo de métodos de corrección de errores sobre los datos transmitidos, usándose generalmente técnicas de codificación Reed-Solomon & Viterbi, por razones de desempeño y seguridad es preferible implementarlos sobre hardware. En este trabajo se presenta el diseño modular de la etapa de codificación de éstos códigos para su concatenación usando VHDL (VHSIC Hardware Descriptor Language, orientado a la implementación sobre tecnología de matriz de compuertas programadas por campo (FPGA, Se inicia con una revisión de los conceptos asociados a la definición de los componentes, y el modelo, descripción del comportamiento, luego la arquitectura es diseñada usando la sintaxis en VHDL y es capturado el diseño de hardware, finalmente se presentan los resultados de síntesis.The wireless communication medium require employing forward error correction methods on the data transferred, where Reed-Solomon & Viterbi coding techniques are utilized, because of performance and security reaso. In this paper we present a modular design of phase encoding these codes for concatenation using VHDL (VHSIC Hardware Descriptor Language and oriented to implementation with field programmable gate arrays (FPGA. The work besing with a review of code concept and the definition of the components and the model and the description of the behavioral. Later, the architecture is designed and captures using syntax in VHDL, and finally presents the results of synthesis.

  7. Duality ensures modular covariance

    International Nuclear Information System (INIS)

    Li Miao; Yu Ming

    1989-11-01

    We show that the modular transformations for one point functions on the torus, S(n), satisfy the polynomial equations derived by Moore and Seiberg, provided the duality property of the model is ensured. The formula for S(n) is derived by us previously and should be valid for any conformal field theory. As a consequence, the full consistency conditions for modular invariance at higher genus are completely guaranteed by duality of the theory on the sphere. (orig.)

  8. Using ADA Tasks to Simulate Operating Equipment

    Science.gov (United States)

    DeAcetis, Louis A.; Schmidt, Oron; Krishen, Kumar

    1990-01-01

    A method of simulating equipment using ADA tasks is discussed. Individual units of equipment are coded as concurrently running tasks that monitor and respond to input signals. This technique has been used in a simulation of the space-to-ground Communications and Tracking subsystem of Space Station Freedom.

  9. New control system: ADA softwares organization

    International Nuclear Information System (INIS)

    David, L.

    1992-01-01

    On VAX/VMS, ADA compiler is integrated in a workshop of ACS software engineering which allows a coherent development by control of source and executable programs, by separation of applications in various levels of visibility and by management of existing links between different modules of a same application. (A.B.)

  10. KYTC sidewalk and curb ramp inventory for ADA compliance.

    Science.gov (United States)

    2017-09-01

    The Americans with Disabilities Act of 1990 (ADA) requires that all public and private organizations providing services to the public ensure their facilities and infrastructure comply with regulations set forth therein. The ADA requires that a transi...

  11. Immunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient.

    Science.gov (United States)

    Liu, Ping; Santisteban, Ines; Burroughs, Lauri M; Ochs, Hans D; Torgerson, Troy R; Hershfield, Michael S; Rawlings, David J; Scharenberg, Andrew M

    2009-02-01

    We report detailed genetic and immunologic studies in a patient diagnosed with adenosine deaminase (ADA) deficiency and combined immune deficiency at age 5 years. At the time of diagnosis, although all other lymphocyte subsets were depleted, circulating CD8(+) T cells with a terminally differentiated phenotype were abundant and expressed normal ADA activity due to a reversion mutation in a CD8(+) T cell or precursor. Over the first 9 months of replacement therapy with PEG-ADA, the patient steadily accumulated mature naïve CD4(+) and CD8(+) T cells, as well as CD4(+)/FOXP3(+) regulatory T cells, consistent with restoration of a functional cellular immune system. While CD19(+) naïve B cells also accumulated in response to PEG-ADA therapy, a high proportion of these B cells exhibited an immature surface marker phenotype even after 9 months, and immunization with neoantigen bacteriophage varphiX174 demonstrated a markedly subnormal humoral immune response. Our observations in this single patient have important implications for gene therapy of human ADA deficiency, as they indicate that ADA expression within even a large circulating lymphocyte population may not be sufficient to support adequate immune reconstitution. They also suggest that an immature surface marker phenotype of the peripheral B cell compartment may be a useful surrogate marker for incomplete humoral immune reconstitution during enzyme replacement, and possibly other forms of hematopoietic cell therapies.

  12. New scoring methodology improves the sensitivity of the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) in clinical trials.

    Science.gov (United States)

    Verma, Nishant; Beretvas, S Natasha; Pascual, Belen; Masdeu, Joseph C; Markey, Mia K

    2015-11-12

    As currently used, the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) has low sensitivity for measuring Alzheimer's disease progression in clinical trials. A major reason behind the low sensitivity is its sub-optimal scoring methodology, which can be improved to obtain better sensitivity. Using item response theory, we developed a new scoring methodology (ADAS-CogIRT) for the ADAS-Cog, which addresses several major limitations of the current scoring methodology. The sensitivity of the ADAS-CogIRT methodology was evaluated using clinical trial simulations as well as a negative clinical trial, which had shown an evidence of a treatment effect. The ADAS-Cog was found to measure impairment in three cognitive domains of memory, language, and praxis. The ADAS-CogIRT methodology required significantly fewer patients and shorter trial durations as compared to the current scoring methodology when both were evaluated in simulated clinical trials. When validated on data from a real clinical trial, the ADAS-CogIRT methodology had higher sensitivity than the current scoring methodology in detecting the treatment effect. The proposed scoring methodology significantly improves the sensitivity of the ADAS-Cog in measuring progression of cognitive impairment in clinical trials focused in the mild-to-moderate Alzheimer's disease stage. This provides a boost to the efficiency of clinical trials requiring fewer patients and shorter durations for investigating disease-modifying treatments.

  13. Modular design in fahion industry

    Directory of Open Access Journals (Sweden)

    Ying Chen

    2018-03-01

    Full Text Available "Modular design" is a kind of design mode that not only can made clothing more interesting, makes the wearer can participate in choices, increase the possibility of clothing style .but also can extend the service cycle of clothing. In this "fast fashion" run market, the design idea of modular design can be a breakthrough point, help us find the way to balance the low-carbon and environmentally-friendly need and fashion. The article will combine the existing examples put the modular design summarized into three categories: component modular design and geometric modular design and compounded modular design.

  14. Preplacement evaluation: thriving within the ADA guidelines.

    Science.gov (United States)

    Pruitt, R H

    1995-03-01

    1. The intent of the Americans With Disabilities Act (ADA) is to remove barriers against those with known disabilities and to require reasonable accommodation to enable qualified employees to perform a job. The ADA is not meant to facilitate those with covert preexisting conditions in setting up workers' compensation and disability claims. 2. Essential job functions are physical and mental requirements for a job that are developed by the supervisor and the occupational health department. These functions should be included with the posting of any position. 3. Preplacement evaluation requirements: essential job functions that are used to determine what is included in the assessment; employee capability statement (with reasonable accommodation); and conditional offer of employment pending a satisfactory post-offer evaluation prior to beginning the job.

  15. Symmetric modular torsatron

    Science.gov (United States)

    Rome, J.A.; Harris, J.H.

    1984-01-01

    A fusion reactor device is provided in which the magnetic fields for plasma confinement in a toroidal configuration is produced by a plurality of symmetrical modular coils arranged to form a symmetric modular torsatron referred to as a symmotron. Each of the identical modular coils is helically deformed and comprise one field period of the torsatron. Helical segments of each coil are connected by means of toroidally directed windbacks which may also provide part of the vertical field required for positioning the plasma. The stray fields of the windback segments may be compensated by toroidal coils. A variety of magnetic confinement flux surface configurations may be produced by proper modulation of the winding pitch of the helical segments of the coils, as in a conventional torsatron, winding the helix on a noncircular cross section and varying the poloidal and radial location of the windbacks and the compensating toroidal ring coils.

  16. Reuse Tools to Support ADA Instantiation Construction

    Science.gov (United States)

    1990-06-01

    specification and body with embedded task shell instantiations, as well as an inter-task coordination procedure which controls task activation, execution, and...Tools to Support Ada Instantiation Construction 3 - Generalized Construction Approaches Page 39 4Automatic Programming Programmer’s Apprentice ~ASLs...which is the root of a frame hierarchy. The specification frame controls the hierarchy’s composition of the program and stores all its custom

  17. The early mathematical education of Ada Lovelace

    OpenAIRE

    Hollings, C; Martin, UM; Rice, A

    2017-01-01

    Ada, Countess of Lovelace, is remembered for a paper published in 1843, which translated and considerably extended an article about the unbuilt Analytical Engine, a general-purpose computer designed by the mathematician and inventor Charles Babbage. Her substantial appendices, nearly twice the length of the original work, contain an account of the principles of the machine, along with a table often described as “the first computer program”. In this paper we look at Lovelace’s education before...

  18. Review of advanced driver assistance systems (ADAS)

    Science.gov (United States)

    Ziebinski, Adam; Cupek, Rafal; Grzechca, Damian; Chruszczyk, Lukas

    2017-11-01

    New cars can be equipped with many advanced safety solutions. Airbags, seatbelts and all of the essential passive safety parts are standard equipment. Now cars are often equipped with new advanced active safety systems that can prevent accidents. The functions of the Advanced Driver Assistance Systems are still growing. A review of the most popular available technologies used in ADAS and descriptions of their application areas are discussed in this paper.

  19. Reliability of the Alzheimer's disease assessment scale (ADAS-Cog) in longitudinal studies.

    Science.gov (United States)

    Khan, Anzalee; Yavorsky, Christian; DiClemente, Guillermo; Opler, Mark; Liechti, Stacy; Rothman, Brian; Jovic, Sofija

    2013-11-01

    Considering the scarcity of longitudinal assessments of reliability, there is need for a more precise understanding of cognitive decline in Alzheimer's Disease (AD). The primary goal was to assess longitudinal changes in inter-rater reliability, test retest reliability and internal consistency of scores of the ADAS-Cog. 2,618 AD subjects were enrolled in seven randomized, double-blind, placebo-controlled, multicenter-trials from 1986 to 2009. Reliability, internal-consistency and cross-sectional analysis of ADAS-Cog and MMSE across seven visits were examined. Intra-class correlation (ICC) for ADAS-Cog was moderate to high supporting their reliability. Absolute Agreement ICCs 0.392 (Visit-7) to 0.806 (Visit-2) showed a progressive decrease in correlations across time. Item analysis revealed a decrease in item correlations, with the lowest correlations for Visit 7 for Commands (ICC=0.148), Comprehension (ICC=0.092), Spoken Language (ICC=0.044). Suitable assessment of AD treatments is maintained through accurate measurement of clinically significant outcomes. Targeted rater education ADAS-Cog items over-time can improve ability to administer and score the scale.

  20. An Ada Linear-Algebra Software Package Modeled After HAL/S

    Science.gov (United States)

    Klumpp, Allan R.; Lawson, Charles L.

    1990-01-01

    New avionics software written more easily. Software package extends Ada programming language to include linear-algebra capabilities similar to those of HAL/S programming language. Designed for such avionics applications as Space Station flight software. In addition to built-in functions of HAL/S, package incorporates quaternion functions used in Space Shuttle and Galileo projects and routines from LINPAK solving systems of equations involving general square matrices. Contains two generic programs: one for floating-point computations and one for integer computations. Written on IBM/AT personal computer running under PC DOS, v.3.1.

  1. The Katydid system for compiling KEE applications to Ada

    Science.gov (United States)

    Filman, Robert E.; Bock, Conrad; Feldman, Roy

    1990-01-01

    Components of a system known as Katydid are developed in an effort to compile knowledge-based systems developed in a multimechanism integrated environment (KEE) to Ada. The Katydid core is an Ada library supporting KEE object functionality, and the other elements include a rule compiler, a LISP-to-Ada translator, and a knowledge-base dumper. Katydid employs translation mechanisms that convert LISP knowledge structures and rules to Ada and utilizes basic prototypes of a run-time KEE object-structure library module for Ada. Preliminary results include the semiautomatic compilation of portions of a simple expert system to run in an Ada environment with the described algorithms. It is suggested that Ada can be employed for AI programming and implementation, and the Katydid system is being developed to include concurrency and synchronization mechanisms.

  2. Criteria for software modularization

    Science.gov (United States)

    Card, David N.; Page, Gerald T.; Mcgarry, Frank E.

    1985-01-01

    A central issue in programming practice involves determining the appropriate size and information content of a software module. This study attempted to determine the effectiveness of two widely used criteria for software modularization, strength and size, in reducing fault rate and development cost. Data from 453 FORTRAN modules developed by professional programmers were analyzed. The results indicated that module strength is a good criterion with respect to fault rate, whereas arbitrary module size limitations inhibit programmer productivity. This analysis is a first step toward defining empirically based standards for software modularization.

  3. The OPEN-ADAS Approach to Atomic Data Provision

    Energy Technology Data Exchange (ETDEWEB)

    O' Mullane, M [University of Strathclyde, Department of Physics, Glasgow (United Kingdom)

    2011-11-15

    Dr O'Mullane of University of Strathclyde presented an overview of the ADAS project (Atomic Data and Analysis Structure, http://www.adas.ac.uk/) and of OPEN-ADAS (http://open.adas.ac.uk/). ADAS is maintained as a self-funding consortium of fusion laboratories. The project provides an interconnected set of computer codes and data collections for modeling the radiating properties of ions and atoms in plasmas. The ADAS data fall into 3 broad classes: 1) Fundamental data such as A- values, cross-sections and effective collision strengths obtained from ADAS collaborators, the literature or data centres. 2) Derived data processed for modeling such as electron temperature and density dependent effective emission coefficients, effective ionization/recombination rates, radiated power and spectral emissivities. 3) Driver data which allow complete regeneration of all ADAS derived data in conjunction with the various ADAS codes. ADAS data uses high quality data as well as baseline data for fall-back when high quality data is not available. The data is mostly embedded in codes and the update without expert help is problematic. The ADAS data formats (adf) are precisely defined and Fortran codes are supplied to read the data sets for easy access. IDL can be used for interactive manipulation. The OPEN-ADAS project is a joint development between the ADAS Project and the IAEA to make the extensive fundamental and derived atomic data for fusion more widely available. It is designed to appeal to both plasma modelers and those interested in the detailed atomic physics. It has been searchable through the Google Scholar and appears in citations, which gives greater visibility and credits to the data producers. The OPEN-ADAS server was replaced due to a series of attacks since June 2011 and was off-line for 8 weeks. The new service removed the registration requirement and hence the user statistics is limited.

  4. The OPEN-ADAS Approach to Atomic Data Provision

    International Nuclear Information System (INIS)

    O'Mullane, M.

    2011-01-01

    Dr O'Mullane of University of Strathclyde presented an overview of the ADAS project (Atomic Data and Analysis Structure, http://www.adas.ac.uk/) and of OPEN-ADAS (http://open.adas.ac.uk/). ADAS is maintained as a self-funding consortium of fusion laboratories. The project provides an interconnected set of computer codes and data collections for modeling the radiating properties of ions and atoms in plasmas. The ADAS data fall into 3 broad classes: 1) Fundamental data such as A- values, cross-sections and effective collision strengths obtained from ADAS collaborators, the literature or data centres. 2) Derived data processed for modeling such as electron temperature and density dependent effective emission coefficients, effective ionization/recombination rates, radiated power and spectral emissivities. 3) Driver data which allow complete regeneration of all ADAS derived data in conjunction with the various ADAS codes. ADAS data uses high quality data as well as baseline data for fall-back when high quality data is not available. The data is mostly embedded in codes and the update without expert help is problematic. The ADAS data formats (adf) are precisely defined and Fortran codes are supplied to read the data sets for easy access. IDL can be used for interactive manipulation. The OPEN-ADAS project is a joint development between the ADAS Project and the IAEA to make the extensive fundamental and derived atomic data for fusion more widely available. It is designed to appeal to both plasma modelers and those interested in the detailed atomic physics. It has been searchable through the Google Scholar and appears in citations, which gives greater visibility and credits to the data producers. The OPEN-ADAS server was replaced due to a series of attacks since June 2011 and was off-line for 8 weeks. The new service removed the registration requirement and hence the user statistics is limited.

  5. Modular High Voltage Power Supply

    Energy Technology Data Exchange (ETDEWEB)

    Newell, Matthew R. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-05-18

    The goal of this project is to develop a modular high voltage power supply that will meet the needs of safeguards applications and provide a modular plug and play supply for use with standard electronic racks.

  6. GRODY - GAMMA RAY OBSERVATORY DYNAMICS SIMULATOR IN ADA

    Science.gov (United States)

    Stark, M.

    1994-01-01

    Analysts use a dynamics simulator to test the attitude control system algorithms used by a satellite. The simulator must simulate the hardware, dynamics, and environment of the particular spacecraft and provide user services which enable the analyst to conduct experiments. Researchers at Goddard's Flight Dynamics Division developed GRODY alongside GROSS (GSC-13147), a FORTRAN simulator which performs the same functions, in a case study to assess the feasibility and effectiveness of the Ada programming language for flight dynamics software development. They used popular object-oriented design techniques to link the simulator's design with its function. GRODY is designed for analysts familiar with spacecraft attitude analysis. The program supports maneuver planning as well as analytical testing and evaluation of the attitude determination and control system used on board the Gamma Ray Observatory (GRO) satellite. GRODY simulates the GRO on-board computer and Control Processor Electronics. The analyst/user sets up and controls the simulation. GRODY allows the analyst to check and update parameter values and ground commands, obtain simulation status displays, interrupt the simulation, analyze previous runs, and obtain printed output of simulation runs. The video terminal screen display allows visibility of command sequences, full-screen display and modification of parameters using input fields, and verification of all input data. Data input available for modification includes alignment and performance parameters for all attitude hardware, simulation control parameters which determine simulation scheduling and simulator output, initial conditions, and on-board computer commands. GRODY generates eight types of output: simulation results data set, analysis report, parameter report, simulation report, status display, plots, diagnostic output (which helps the user trace any problems that have occurred during a simulation), and a permanent log of all runs and errors. The

  7. Adaptive Modular Playware

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop; Þorsteinsson, Arnar Tumi

    2011-01-01

    In this paper, we describe the concept of adaptive modular playware, where the playware adapts to the interaction of the individual user. We hypothesize that there are individual differences in user interaction capabilities and styles, and that adaptive playware may adapt to the individual user...

  8. Modularization of Courses.

    Science.gov (United States)

    Eastern Arizona Coll., Thatcher.

    Eastern Arizona College has developed a modularized system of instruction for five vocational and vocationally related courses--Introduction to Business, Business Mathematics, English, Drafting, and Electronics. Each course is divided into independent segments of instruction and students have open-entry and exit options. This document reviews the…

  9. Modular Cure Provision

    DEFF Research Database (Denmark)

    Winther-Hansen, Casper; Frandsen, Thomas

    facilitate co-creation through open platforms and service modularity. Based on data from two pharmaceuticals we explore issues of governance related to the relative openness of platforms and their completeness. Whereas some pharmaceuticals should cater to sophisticated needs of competent users through open...

  10. The Challenges of Modularization.

    Science.gov (United States)

    Brown, Sally; Saunders, Danny

    1995-01-01

    Discusses the movement towards credit accumulation and transfer in higher education institutions based on experiences at two universities in the United Kingdom, the University of Northumbria and the University of Glamorgan. Modularization, or unitization, and semesterization are considered, and three key areas are addressed: management, student…

  11. Modular co-ordination

    DEFF Research Database (Denmark)

    Blach, K.

    Notatet er på engelsk, idet det er lavet som et oplæg til den internationale standardiseringsorganisations (ISO) arbejde med målkoordinering i byggeriet. Materialet har også været forelagt ekspertgrupperne i CIB W24 og i International Modular Group. Det i notatet præsenterede materiale er blevet...

  12. MRV - Modular Robotic Vehicle

    Science.gov (United States)

    Ridley, Justin; Bluethmann, Bill

    2015-01-01

    The Modular Robotic Vehicle, or MRV, completed in 2013, was developed at the Johnson Space Center in order to advance technologies which have applications for future vehicles both in space and on Earth. With seating for two people, MRV is a fully electric vehicle modeled as a "city car", suited for busy urban environments.

  13. Reviews: Effects of transdermal rivastigmine on ADAS-cog items in mild-to-moderate Alzheimer's disease.

    Science.gov (United States)

    Grossberg, George T; Schmitt, Frederick A; Meng, Xiangyi; Tekin, Sibel; Olin, Jason

    2010-12-01

    Alzheimer's disease (AD) patients treated with rivastigmine transdermal patch have shown statistically significant differences versus placebo on the AD Assessment scale-cognitive subscale (ADAS-cog). In this retrospective analysis of a double-blind, placebo- and active-controlled, 24-week clinical trial, the specific effects of rivastigmine patch on individual ADAS-cog items and cognitive domains (memory, language, and praxis) were explored. The mean baseline to week 24 changes were calculated for each ADAS-cog item and domain in this exploratory, hypothesis-generating analysis. Patients on 9.5 mg/24 h rivastigmine patch, 17.4 mg/24 h rivastigmine patch, and 3 to 12 mg/d rivastigmine capsules showed improvements over placebo on the memory and praxis ADAS-cog subscales. The rivastigmine patch groups also showed improvements on the language subscale. Significant differences versus placebo were seen on several individual item scores in the rivastigmine-treated groups. Rivastigmine patch was associated with improvements on the memory, praxis, and language domains of cognition in patients with mild-to-moderate AD.

  14. An Arabic Version of the Cognitive Subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog): Reliability, Validity, and Normative Data.

    Science.gov (United States)

    Ben Jemaa, Sonia; Attia Romdhane, Neila; Bahri-Mrabet, Amel; Jendli, Adel; Le Gall, Didier; Bellaj, Tarek

    2017-01-01

    The Alzheimer's Disease Assessment Scale's cognitive subscale (ADAS-Cog) is the most widely used instrument for screening cognitive dysfunction in Alzheimer's disease. The aim of the present study was to develop an Arabic version of this scale (A-ADAS-Cog), examine its psychometric properties (reliability and validity), and provide normative data. The A-ADAS-Cog), an Arabic version of the Mini-Mental State Examination (A-MMSE), and a Standardized Clinical Dementia Rating Scale (CDR) were administered to three Tunisian groups: 124 normal controls (NC), 33 patients with non-Alzheimer dementia (N-AD), and 25 patients with Alzheimer's disease (AD). The A-ADAS-Cog scores were significantly affected by age and education. A correction table was constructed to control these effects. The results showed that the A-ADAS-Cog has good internal consistency and reliability (α= 0.82 for AD). The test-retest reliability of the A-ADAS-Cog was stable over time (r = 0.97). An evaluation of the construct validity of the A-ADAS-Cog using principal component analysis led to a solution with three factors (memory, language and praxis), which explained 72% of the variance. The concurrent validity of the A-ADAS-Cog was established using the A-MMSE score (r = -0.86), CDR Sum of Boxes score (CDR-SB; r = 0.87), and global CDR score (CDR-Global; r = 0.74). Finally, the A-ADAS-Cog has an excellent discriminating power in the diagnosis of AD (ROC area = 0.92). A cut-off score of 10 (sensitivity = 84% and specificity = 91%) is indicated for the screening of the AD. Overall, the results indicated that the A-ADAS-Cog is psychometrically reliable and valid and provides promising results for screening of dementia in Arabic speaking patients.

  15. QUEST/Ada: Query utility environment for software testing of Ada

    Science.gov (United States)

    Brown, David B.

    1989-01-01

    Results of research and development efforts are presented for Task 1, Phase 2 of a general project entitled, The Development of a Program Analysis Environment for Ada. A prototype of the QUEST/Ada system was developed to collect data to determine the effectiveness of the rule-based testing paradigm. The prototype consists of five parts: the test data generator, the parser/scanner, the test coverage analyzer, a symbolic evaluator, and a data management facility, known as the Librarian. These components are discussed at length. Also presented is an experimental design for the evaluations, an overview of the project, and a schedule for its completion.

  16. Software engineering and Ada (Trademark) training: An implementation model for NASA

    Science.gov (United States)

    Legrand, Sue; Freedman, Glenn

    1988-01-01

    The choice of Ada for software engineering for projects such as the Space Station has resulted in government and industrial groups considering training programs that help workers become familiar with both a software culture and the intricacies of a new computer language. The questions of how much time it takes to learn software engineering with Ada, how much an organization should invest in such training, and how the training should be structured are considered. Software engineering is an emerging, dynamic discipline. It is defined by the author as the establishment and application of sound engineering environments, tools, methods, models, principles, and concepts combined with appropriate standards, guidelines, and practices to support computing which is correct, modifiable, reliable and safe, efficient, and understandable throughout the life cycle of the application. Neither the training programs needed, nor the content of such programs, have been well established. This study addresses the requirements for training for NASA personnel and recommends an implementation plan. A curriculum and a means of delivery are recommended. It is further suggested that a knowledgeable programmer may be able to learn Ada in 5 days, but that it takes 6 to 9 months to evolve into a software engineer who uses the language correctly and effectively. The curriculum and implementation plan can be adapted for each NASA Center according to the needs dictated by each project.

  17. Model-based Kinematics Generation for Modular Mechatronic Toolkits

    DEFF Research Database (Denmark)

    Bordignon, Mirko; Schultz, Ulrik Pagh; Støy, Kasper

    2011-01-01

    Modular robots are mechatronic devices that enable the construction of highly versatile and flexible robotic systems whose mechanical structure can be dynamically modified. The key feature that enables this dynamic modification is the capability of the individual modules to connect to each other...... in multiple ways and thus generate a number of different mechanical systems, in contrast with the monolithic, fixed structure of conventional robots. The mechatronic flexibility, however, complicates the development of models and programming abstractions for modular robots, since manually describing...... the Modular Mechatronics Modelling Language (M3L). M3L is a domain-specific language, which can model the kinematic structure of individual robot modules and declaratively describe their possible interconnections, rather than requiring the user to enumerate them in their entirety. From this description, the M...

  18. Modularization of Industrial Service Processes

    DEFF Research Database (Denmark)

    Frandsen, Thomas; Hsuan, Juliana

    In this paper we examine how complex service processes can be dealt with through the lenses of modularization strategies. Through an illustrative case study of a manufacturer of industrial equipment for process industries we propose the use of the service modularity function to conceptualize...... and assess the service modularity of service offerings. The measured degree of modularity would allow us to sharpen our understanding of modularity in the context of industrial services, such as the role of standardization and component reuse on architecture flexibility. It would also provide a foundation...

  19. Restoring balance to B cells in ADA deficiency.

    Science.gov (United States)

    Luning Prak, Eline T

    2012-06-01

    It is paradoxical that immunodeficiency disorders are associated with autoimmunity. Adenosine deaminase (ADA) deficiency, a cause of X-linked severe combined immunodeficiency (SCID), is a case in point. In this issue of the JCI, Sauer and colleagues investigate the B cell defects in ADA-deficient patients. They demonstrate that ADA patients receiving enzyme replacement therapy had B cell tolerance checkpoint defects. Remarkably, gene therapy with a retrovirus that expresses ADA resulted in the apparent correction of these defects, with normalization of peripheral B cell autoantibody frequencies. In vitro, agents that either block ADA or overexpress adenosine resulted in altered B cell receptor and TLR signaling. Collectively, these data implicate a B cell-intrinsic mechanism for alterations in B cell tolerance in the setting of partial ADA deficiency that is corrected by gene therapy.

  20. Modular Open-Source Software for Item Factor Analysis

    Science.gov (United States)

    Pritikin, Joshua N.; Hunter, Micheal D.; Boker, Steven M.

    2015-01-01

    This article introduces an item factor analysis (IFA) module for "OpenMx," a free, open-source, and modular statistical modeling package that runs within the R programming environment on GNU/Linux, Mac OS X, and Microsoft Windows. The IFA module offers a novel model specification language that is well suited to programmatic generation…

  1. Relationships between cognitive impairment on ADAS-cog and regional cerebral blood flow using SPECT in late-onset Alzheimer's disease.

    Science.gov (United States)

    Takahashi, Michio; Oda, Yasunori; Okubo, Toshiyuki; Shirayama, Yukihiko

    2017-09-01

    The aim of this study was to examine brain hypoperfusion and its relationship with cognitive dysfunction in late-onset Alzheimer's disease (AD). Forty patients with late-onset AD and not receiving acetylcholinesterase inhibitors were recruited from outpatient clinics. We examined cognitive function using the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) and brain perfusion using single-photon emission computed tomography, and analyzed classified gyrus level segments with three-dimensional stereotactic surface projection and the stereotactic extraction estimation method level 3. ADAS-cog subscales were grouped into three domains: language, memory, and praxis. Patients with late-onset AD showed an apparent reduction in regional cerebral blood flow (rCBF) with a z score >1.5 in the frontal, temporal, and limbic lobes, with lesser reduction in the parietal and occipital lobes. Although hypoperfusion in the orbital, rectal, and subcallosal gyri of the frontal lobe was prominent, rCBF in the inferior frontal gyrus of the frontal lobe was significantly correlated with ADAS-cog total and language and praxis subscale scores. The parahippocampal gyrus of the limbic lobe was also significantly correlated with the ADAS-cog total, language, and praxis subscale scores. Additionally, the cingulate of the limbic lobe was significantly related with ADAS-cog memory. In spite of lesser hypoperfusion, the posterior cingulate gyrus of the limbic lobe was significantly related with ADAS-cog total, language, and memory subscale scores. Further, each subdivision of ADAS-cog was found to be related with various brain regions.

  2. The universal modular platform

    International Nuclear Information System (INIS)

    North, R.B.

    1995-01-01

    A new and patented design for offshore wellhead platforms has been developed to meet a 'fast track' requirement for increased offshore production, from field locations not yet identified. The new design uses modular construction to allow for radical changes in the water depth of the final location and assembly line efficiency in fabrication. By utilizing high strength steels and structural support from the well conductors the new design accommodates all planned production requirements on a support structure significantly lighter and less expensive than the conventional design it replaces. Twenty two platforms based on the new design were ready for installation within 18 months of the project start. Installation of the new platforms began in 1992 for drilling support and 1993 for production support. The new design has become the Company standard for all future production platforms. Large saving and construction costs have been realized through its light weight, flexibility in both positioning and water depth, and its modular construction

  3. Modular chemiresistive sensor

    Energy Technology Data Exchange (ETDEWEB)

    Alam, Maksudul M.; Sampathkumaran, Uma

    2018-02-20

    The present invention relates to a modular chemiresistive sensor. In particular, a modular chemiresistive sensor for hypergolic fuel and oxidizer leak detection, carbon dioxide monitoring and detection of disease biomarkers. The sensor preferably has two gold or platinum electrodes mounted on a silicon substrate where the electrodes are connected to a power source and are separated by a gap of 0.5 to 4.0 .mu.M. A polymer nanowire or carbon nanotube spans the gap between the electrodes and connects the electrodes electrically. The electrodes are further connected to a circuit board having a processor and data storage, where the processor can measure current and voltage values between the electrodes and compare the current and voltage values with current and voltage values stored in the data storage and assigned to particular concentrations of a pre-determined substance such as those listed above or a variety of other substances.

  4. Fast quantum modular exponentiation

    International Nuclear Information System (INIS)

    Meter, Rodney van; Itoh, Kohei M.

    2005-01-01

    We present a detailed analysis of the impact on quantum modular exponentiation of architectural features and possible concurrent gate execution. Various arithmetic algorithms are evaluated for execution time, potential concurrency, and space trade-offs. We find that to exponentiate an n-bit number, for storage space 100n (20 times the minimum 5n), we can execute modular exponentiation 200-700 times faster than optimized versions of the basic algorithms, depending on architecture, for n=128. Addition on a neighbor-only architecture is limited to O(n) time, whereas non-neighbor architectures can reach O(log n), demonstrating that physical characteristics of a computing device have an important impact on both real-world running time and asymptotic behavior. Our results will help guide experimental implementations of quantum algorithms and devices

  5. Modular Mobile Application Design

    OpenAIRE

    Jim Hahn; Nathaniel Ryckman

    2012-01-01

    This article describes the development of the Minrva library app for Android phones. The decisions to build a native application with Java and use a modular design are discussed. The application includes five modules: catalog search, in-building navigation, a barcode scanning feature, and up to date notifications of circulating technology availability. A sixth module, Amazon recommendations, that is not included in the version of the app that was released is also discussed. The article also r...

  6. Modular remote radiation monitor

    International Nuclear Information System (INIS)

    Lacerda, Fabio; Farias, Marcos S.; Aghina, Mauricio A.C.; Oliveira, Mauro V.

    2013-01-01

    The Modular Remote Radiation Monitor (MRRM) is a novel radiation monitor suitable for monitoring environmental exposure to ionizing radiation. It is a portable compact-size low-power microprocessor-based electronic device which provides its monitoring data to other electronic systems, physically distant from it, by means of an electronic communication channel, which can be wired or wireless according to the requirements of each application. Besides its low-power highly-integrated circuit design, the Modular Remote Radiation Monitor is presented in a modular architecture, which promotes full compliance to the technical requirements of different applications while minimizing cost, size and power consumption. Its communication capability also supports the implementation of a network of multiple radiation monitors connected to a supervisory system, capable of remotely controlling each monitor independently as well as visualizing the radiation levels from all monitors. A prototype of the MRRM, functionally equivalent to the MRA-7027 radiation monitor, was implemented and connected to a wired MODBUS network of MRA-7027 monitors, responsible for monitoring ionizing radiation inside Argonauta reactor room at Instituto de Engenharia Nuclear. Based on the highly positive experimental results obtained, further design is currently underway in order to produce a consumer version of the MRRM. (author)

  7. On sub-modularization and morphological heterogeneity in modular robotics

    DEFF Research Database (Denmark)

    Lyder, A. H.; Stoy, K.; Garciá, R. F. M.

    2012-01-01

    Modular robots are a kind of robots built from mechatronic modules, which can be assembled in many different ways allowing the modular robot to assume a wide range of morphologies and functions. An important question in modular robotics is to which degree modules should be heterogeneous....... In this paper we introduce two contributing factors to heterogeneity namely morphological heterogeneity and sub-functional modularization. Respectively, the ideas are to create modules with significantly different morphologies and to spread sub-functionality across modules. Based on these principles we design...... and implement the Thor robot and evaluate it by participating in the ICRA Planetary Robotic Contingency Challenge. The Thor robot demonstrates that sub-functional modularity and morphological heterogeneity may increase the versatility of modular robots while reducing the complexity of individual modules, which...

  8. [Modular enteral nutrition in pediatrics].

    Science.gov (United States)

    Murillo Sanchís, S; Prenafeta Ferré, M T; Sempere Luque, M D

    1991-01-01

    Modular Enteral Nutrition may be a substitute for Parenteral Nutrition in children with different pathologies. Study of 4 children with different pathologies selected from a group of 40 admitted to the Maternal-Childrens Hospital "Valle de Hebrón" in Barcelona, who received modular enteral nutrition. They were monitored on a daily basis by the Dietician Service. Modular enteral nutrition consists of modules of proteins, peptides, lipids, glucids and mineral salts-vitamins. 1.--Craneo-encephalic traumatisms with loss of consciousness, Feeding with a combination of parenteral nutrition and modular enteral nutrition for 7 days. In view of the tolerance and good results of the modular enteral nutrition, the parenteral nutrition was suspended and modular enteral nutrition alone used up to a total of 43 days. 2.--55% burns with 36 days of hyperproteic modular enteral nutrition together with normal feeding. A more rapid recovery was achieved with an increase in total proteins and albumin. 3.--Persistent diarrhoea with 31 days of modular enteral nutrition, 5 days on parenteral nutrition alone and 8 days on combined parenteral nutrition and modular enteral nutrition. In view of the tolerance and good results of the modular enteral nutrition, the parenteral nutrition was suspended. 4.--Mucoviscidosis with a total of 19 days on modular enteral nutrition, 12 of which were exclusively on modular enteral nutrition and 7 as a night supplement to normal feeding. We administered proteic intakes of up to 20% of the total calorific intake and in concentrations of up to 1.2 calories/ml of the final preparation, always with a good tolerance. Modular enteral nutrition can and should be used as a substitute for parenteral nutrition in children with different pathologies, thus preventing the complications inherent in parenteral nutrition.

  9. Modular organization and hospital performance.

    Science.gov (United States)

    Kuntz, Ludwig; Vera, Antonio

    2007-02-01

    The concept of modularization represents a modern form of organization, which contains the vertical disaggregation of the firm and the use of market mechanisms within hierarchies. The objective of this paper is to examine whether the use of modular structures has a positive effect on hospital performance. The empirical section makes use of multiple regression analyses and leads to the main result that modularization does not have a positive effect on hospital performance. However, the analysis also finds out positive efficiency effects of two central ideas of modularization, namely process orientation and internal market mechanisms.

  10. Modular analysis of biological networks.

    Science.gov (United States)

    Kaltenbach, Hans-Michael; Stelling, Jörg

    2012-01-01

    The analysis of complex biological networks has traditionally relied on decomposition into smaller, semi-autonomous units such as individual signaling pathways. With the increased scope of systems biology (models), rational approaches to modularization have become an important topic. With increasing acceptance of de facto modularity in biology, widely different definitions of what constitutes a module have sparked controversies. Here, we therefore review prominent classes of modular approaches based on formal network representations. Despite some promising research directions, several important theoretical challenges remain open on the way to formal, function-centered modular decompositions for dynamic biological networks.

  11. Robotic hand with modular extensions

    Science.gov (United States)

    Salisbury, Curt Michael; Quigley, Morgan

    2015-01-20

    A robotic device is described herein. The robotic device includes a frame that comprises a plurality of receiving regions that are configured to receive a respective plurality of modular robotic extensions. The modular robotic extensions are removably attachable to the frame at the respective receiving regions by way of respective mechanical fuses. Each mechanical fuse is configured to trip when a respective modular robotic extension experiences a predefined load condition, such that the respective modular robotic extension detaches from the frame when the load condition is met.

  12. Fine-Tuning ADAS Algorithm Parameters for Optimizing Traffic ...

    Science.gov (United States)

    With the development of the Connected Vehicle technology that facilitates wirelessly communication among vehicles and road-side infrastructure, the Advanced Driver Assistance Systems (ADAS) can be adopted as an effective tool for accelerating traffic safety and mobility optimization at various highway facilities. To this end, the traffic management centers identify the optimal ADAS algorithm parameter set that enables the maximum improvement of the traffic safety and mobility performance, and broadcast the optimal parameter set wirelessly to individual ADAS-equipped vehicles. After adopting the optimal parameter set, the ADAS-equipped drivers become active agents in the traffic stream that work collectively and consistently to prevent traffic conflicts, lower the intensity of traffic disturbances, and suppress the development of traffic oscillations into heavy traffic jams. Successful implementation of this objective requires the analysis capability of capturing the impact of the ADAS on driving behaviors, and measuring traffic safety and mobility performance under the influence of the ADAS. To address this challenge, this research proposes a synthetic methodology that incorporates the ADAS-affected driving behavior modeling and state-of-the-art microscopic traffic flow modeling into a virtually simulated environment. Building on such an environment, the optimal ADAS algorithm parameter set is identified through an optimization programming framework to enable th

  13. The ADA and IDEA Basics: Inclusion of Children with Disabilities

    Science.gov (United States)

    Motwani, Mona

    2007-01-01

    This article discusses the American with Disabilities Act (ADA) and the Individuals with Disabilities Education Act (IDEA). The ADA is a federal civil rights law that was passed in 1990 with the aim of securing equal rights for persons with disabilities in the employment, housing, government, transportation, and public accommodation contexts. It…

  14. State of the art Advanced Driver Assistance Systems (ADAS).

    NARCIS (Netherlands)

    OEI, H.-L.

    2017-01-01

    An overview of state-of-the-art ADA Advanced Driver Assistance systems is given. First a main structuring system for the ADA systems is presented, needed for purposes of relevancy, and consistency : the three phases in the accident process, i.e. pre-crash, crash and post-crash; the driving task at

  15. Modular PNML revisited: Some ideas for strict typing

    DEFF Research Database (Denmark)

    Kindler, Ekkart

    2007-01-01

    The Petri Net Markup Language (PNML) is currently standardised by ISO/IEC JTC1/SC7 WG 19 as Part 2 of ISO/IEC 15909. But, there is not yet a mechanism for structuring large Petri nets and for constructing Petri nets from modules. To this end, modular PNML has been proposed some time ago. But, mod...... of Petri net, but still has a strict type system. This paper focuses on the ideas and concepts; the technical details still need to be worked out. To this end, this paper also raises some issues and questions that need to be discussed before standardising modular PNML....

  16. Modular biometric system

    Science.gov (United States)

    Hsu, Charles; Viazanko, Michael; O'Looney, Jimmy; Szu, Harold

    2009-04-01

    Modularity Biometric System (MBS) is an approach to support AiTR of the cooperated and/or non-cooperated standoff biometric in an area persistent surveillance. Advanced active and passive EOIR and RF sensor suite is not considered here. Neither will we consider the ROC, PD vs. FAR, versus the standoff POT in this paper. Our goal is to catch the "most wanted (MW)" two dozens, separately furthermore ad hoc woman MW class from man MW class, given their archrivals sparse front face data basis, by means of various new instantaneous input called probing faces. We present an advanced algorithm: mini-Max classifier, a sparse sample realization of Cramer-Rao Fisher bound of the Maximum Likelihood classifier that minimize the dispersions among the same woman classes and maximize the separation among different man-woman classes, based on the simple feature space of MIT Petland eigen-faces. The original aspect consists of a modular structured design approach at the system-level with multi-level architectures, multiple computing paradigms, and adaptable/evolvable techniques to allow for achieving a scalable structure in terms of biometric algorithms, identification quality, sensors, database complexity, database integration, and component heterogenity. MBS consist of a number of biometric technologies including fingerprints, vein maps, voice and face recognitions with innovative DSP algorithm, and their hardware implementations such as using Field Programmable Gate arrays (FPGAs). Biometric technologies and the composed modularity biometric system are significant for governmental agencies, enterprises, banks and all other organizations to protect people or control access to critical resources.

  17. Modular gamma systems

    International Nuclear Information System (INIS)

    Millegan, D.R.; Nixon, K.V.

    1982-01-01

    Nuclear safeguards requires sensitive, easily operated instruments for rapid inspection of personnel and vehicles to ensure that no uranium or plutonium is being diverted. Two portable gamma-ray detection systems have been developed. The Modular Gamma System (MGS) is very sensitive and two or more systems can be connected for even better performance. The multiunit configuration can be deployed by motor vehicle for search of large areas too extensive to search on foot. The Programmable Rate Monitor (PRM) is less sensitive but much smaller and therefore is more suitable for search of vehicles, personnel, or smaller areas. The PRM is programmable, which implements measurement and alarm algorithms for individual applications

  18. Emotion, Modularity and Rationalaction

    OpenAIRE

    Martínez Manrique, Fernando; Universidad de Granada

    2009-01-01

    Contemporary theories of emotion view it as related to rational action. This paper begins stating two ways in which a system could be deemed rational, which I call the contributive and constitutive way. I assess the possibility whether emotion can be rational in both ways, as a system capable of producing rational action by itself. To this end I analyze the modular view of emotion, especially in a version of dual-system theory. I will argue that this view has at least two problems –the proble...

  19. Modular Mobile Application Design

    Directory of Open Access Journals (Sweden)

    Jim Hahn

    2012-10-01

    Full Text Available This article describes the development of the Minrva library app for Android phones. The decisions to build a native application with Java and use a modular design are discussed. The application includes five modules: catalog search, in-building navigation, a barcode scanning feature, and up to date notifications of circulating technology availability. A sixth module, Amazon recommendations, that is not included in the version of the app that was released is also discussed. The article also reports on the findings of two rounds of usability testing and the plans for future development of the app.

  20. Modular power station

    Energy Technology Data Exchange (ETDEWEB)

    Inoue, T; Kanazawa, T

    1979-03-19

    In order to shorten the construction period of powerstations, to reduce the number of specialists at site and to prevent technical breakdowns, it was proposed that considerable parts of the powerstation should be assembled on a floating platform and then be towed to site by water, where they are set on foundations and then connected. It is now proposed that the necessary additional equipment (such as water supply plant, storage plant, Diesel generator and service buildings etc.) should be assembled on a second platform, and also transported by water on this. This modular construction will also reduce costs.

  1. Modular Biometric Monitoring System

    Science.gov (United States)

    Chmiel, Alan J. (Inventor); Humphreys, Bradley T. (Inventor)

    2017-01-01

    A modular system for acquiring biometric data includes a plurality of data acquisition modules configured to sample biometric data from at least one respective input channel at a data acquisition rate. A representation of the sampled biometric data is stored in memory of each of the plurality of data acquisition modules. A central control system is in communication with each of the plurality of data acquisition modules through a bus. The central control system is configured to control communication of data, via the bus, with each of the plurality of data acquisition modules.

  2. Rivastigmine in Alzheimer's disease and Parkinson's disease dementia: an ADAS-cog factor analysis.

    Science.gov (United States)

    Weintraub, Daniel; Somogyi, Monique; Meng, Xiangyi

    2011-09-01

    Rivastigmine treatment is associated with significant improvements on the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-cog) in patients with mild-to-moderate Alzheimer's disease (AD) and Parkinson's disease dementia (PDD). Both AD and PDD are purported to have different profiles of cognitive impairment, which may respond differentially to rivastigmine treatment. This was a retrospective analysis of 3 randomized, double-blind, rivastigmine trial databases (Investigation of transDermal Exelon in ALzheimer's disease [IDEAL; AD], EXelon in PaRkinson's disEaSe dementia Study [EXPRESS; PDD], and Alzheimer's Disease with ENA 713 [ADENA; AD]). Factor analyses of the 11 baseline ADAS-cog items derived the same factors in the 2 diseases, that is, "memory" and "language". Rivastigmine-treated AD and PDD patients showed significant improvements (P < .0001 versus placebo) on both factors. For both AD and PDD, rivastigmine had a numerically greater effect on memory than language. Treatment effect sizes were numerically greater in PDD compared with AD. Rivastigmine treatment is associated with improvement in memory and language in AD and PDD. The numerically greater response in PDD is consistent with greater cholinergic deficits in this disease state.

  3. QAL: a language for nuclear physics data acquisition

    International Nuclear Information System (INIS)

    Perry, D.G.

    1979-01-01

    QAL is a data-acquisition language designed to facilitate the experimental interface to the LAMPF-designed Q data-acquisition system. The language constructs available are reviewed. The language is designed around the CAMAC standard and provides experimenters a language interface to the hardware which is easy to understand. Software written in the QAL language is modular and simple to modify

  4. AdaFF: Adaptive Failure-Handling Framework for Composite Web Services

    Science.gov (United States)

    Kim, Yuna; Lee, Wan Yeon; Kim, Kyong Hoon; Kim, Jong

    In this paper, we propose a novel Web service composition framework which dynamically accommodates various failure recovery requirements. In the proposed framework called Adaptive Failure-handling Framework (AdaFF), failure-handling submodules are prepared during the design of a composite service, and some of them are systematically selected and automatically combined with the composite Web service at service instantiation in accordance with the requirement of individual users. In contrast, existing frameworks cannot adapt the failure-handling behaviors to user's requirements. AdaFF rapidly delivers a composite service supporting the requirement-matched failure handling without manual development, and contributes to a flexible composite Web service design in that service architects never care about failure handling or variable requirements of users. For proof of concept, we implement a prototype system of the AdaFF, which automatically generates a composite service instance with Web Services Business Process Execution Language (WS-BPEL) according to the users' requirement specified in XML format and executes the generated instance on the ActiveBPEL engine.

  5. 76 FR 38124 - Applications for New Awards; Americans With Disabilities Act (ADA) National Network Regional...

    Science.gov (United States)

    2011-06-29

    ... DEPARTMENT OF EDUCATION Applications for New Awards; Americans With Disabilities Act (ADA) National Network Regional Centers and ADA National Network Collaborative Research Projects AGENCY: Office... Rehabilitation Research Projects and Centers Program--Disability Rehabilitation Research Projects (DRRP)--ADA...

  6. 76 FR 38129 - Applications for New Awards; Americans With Disabilities Act (ADA) National Network Knowledge...

    Science.gov (United States)

    2011-06-29

    ... DEPARTMENT OF EDUCATION Applications for New Awards; Americans With Disabilities Act (ADA) National Network Knowledge Translation Center (ADA KT Center) AGENCY: Office of Special Education and... Program--Disability Rehabilitation Research Projects (DRRP)--The ADA National Network Knowledge...

  7. Modular Robotic Vehicle

    Science.gov (United States)

    Borroni-Bird, Christopher E. (Inventor); Vitale, Robert L. (Inventor); Lee, Chunhao J. (Inventor); Ambrose, Robert O. (Inventor); Bluethmann, William J. (Inventor); Junkin, Lucien Q. (Inventor); Lutz, Jonathan J. (Inventor); Guo, Raymond (Inventor); Lapp, Anthony Joseph (Inventor); Ridley, Justin S. (Inventor)

    2015-01-01

    A modular robotic vehicle includes a chassis, driver input devices, an energy storage system (ESS), a power electronics module (PEM), modular electronic assemblies (eModules) connected to the ESS via the PEM, one or more master controllers, and various embedded controllers. Each eModule includes a drive wheel containing a propulsion-braking module, and a housing containing propulsion and braking control assemblies with respective embedded propulsion and brake controllers, and a mounting bracket covering a steering control assembly with embedded steering controllers. The master controller, which is in communication with each eModule and with the driver input devices, communicates with and independently controls each eModule, by-wire, via the embedded controllers to establish a desired operating mode. Modes may include a two-wheel, four-wheel, diamond, and omni-directional steering modes as well as a park mode. A bumper may enable docking with another vehicle, with shared control over the eModules of the vehicles.

  8. Fable: Socially Interactive Modular Robot

    DEFF Research Database (Denmark)

    Magnússon, Arnþór; Pacheco, Moises; Moghadam, Mikael

    2013-01-01

    Modular robots have a significant potential as user-reconfigurable robotic playware, but often lack sufficient sensing for social interaction. We address this issue with the Fable modular robotic system by exploring the use of smart sensor modules that has a better ability to sense the behavior...

  9. Modular Engineering of Production Plants

    DEFF Research Database (Denmark)

    Miller, Thomas Dedenroth

    1998-01-01

    Based on a case-study on design of pharmaceutical production plants, this paper suggests that modularity may support business efficiency for companies with one-of-a-kind production and without in-house manufacturing. Modularity may support efficient management of design knowledge and may facilitate...

  10. ADAS: Atomic data, modelling and analysis for fusion

    International Nuclear Information System (INIS)

    Summers, H. P.; O'Mullane, M. G.; Whiteford, A. D.; Badnell, N. R.; Loch, S. D.

    2007-01-01

    The Atomic Data and Analysis Structure, ADAS, comprises extensive fundamental and derived atomic data collections, interactive codes for the manipulation and generation of collisional-radiative data and models, off-line codes for large scale fundamental atomic data production and codes for diagnostic analysis in the fusion and astrophysical environments. ADAS data are organized according to precise specifications, tuned to application and are assigned to numbered ADAS data formats. Some of these formats contain very large quantities of data and some have achieved wide-scale adoption in the fusion community.The paper focuses on recent extensions of ADAS designed to orient ADAS to the needs of ITER. The issue of heavy atomic species, expected to be present as ITER wall and divertor materials, dopants or control species, will be addressed with a view to the economized handling of the emission and ionisation state data needed for diagnostic spectral analysis. Charge exchange and beam emission spectroscopic capabilities and developments in ADAS will be reviewed from an ITER perspective and in the context of a shared analysis between fusion laboratories. Finally an overview and summary of current large scale fundamental data production in the framework of the ADAS project will be given and its intended availability in both fusion and astrophysics noted

  11. Modular Flooring System

    Science.gov (United States)

    Thate, Robert

    2012-01-01

    The modular flooring system (MFS) was developed to provide a portable, modular, durable carpeting solution for NASA fs Robotics Alliance Project fs (RAP) outreach efforts. It was also designed to improve and replace a modular flooring system that was too heavy for safe use and transportation. The MFS was developed for use as the flooring for various robotics competitions that RAP utilizes to meet its mission goals. One of these competitions, the FIRST Robotics Competition (FRC), currently uses two massive rolls of broadloom carpet for the foundation of the arena in which the robots are contained during the competition. The area of the arena is approximately 30 by 72 ft (approximately 9 by 22 m). This carpet is very cumbersome and requires large-capacity vehicles, and handling equipment and personnel to transport and deploy. The broadloom carpet sustains severe abuse from the robots during a regular three-day competition, and as a result, the carpet is not used again for competition. Similarly, broadloom carpets used for trade shows at convention centers around the world are typically discarded after only one use. This innovation provides a green solution to this wasteful practice. Each of the flooring modules in the previous system weighed 44 lb (.20 kg). The improvements in the overall design of the system reduce the weight of each module by approximately 22 lb (.10 kg) (50 %), and utilize an improved "module-to-module" connection method that is superior to the previous system. The MFS comprises 4-by-4-ft (.1.2-by- 1.2-m) carpet module assemblies that utilize commercially available carpet tiles that are bonded to a lightweight substrate. The substrate surface opposite from the carpeted surface has a module-to-module connecting interface that allows for the modules to be connected, one to the other, as the modules are constructed. This connection is hidden underneath the modules, creating a smooth, co-planar flooring surface. The modules are stacked and strapped

  12. Applications of an architecture design and assessment system (ADAS)

    Science.gov (United States)

    Gray, F. Gail; Debrunner, Linda S.; White, Tennis S.

    1988-01-01

    A new Architecture Design and Assessment System (ADAS) tool package is introduced, and a range of possible applications is illustrated. ADAS was used to evaluate the performance of an advanced fault-tolerant computer architecture in a modern flight control application. Bottlenecks were identified and possible solutions suggested. The tool was also used to inject faults into the architecture and evaluate the synchronization algorithm, and improvements are suggested. Finally, ADAS was used as a front end research tool to aid in the design of reconfiguration algorithms in a distributed array architecture.

  13. Ada Lovelace : a primeira programadora da história

    OpenAIRE

    Martins, Maria do Carmo

    2016-01-01

    Ada Augusta King, Condessa de Lovelace, sendo conhecida como Ada Lovelace nasceu a 10 de dezembro de 1815 em Londres. Foi uma matemática e escritora inglesa, autora do primeiro algoritmo para ser processado por uma máquina, a máquina analítica de Charles Babbage, um computador proposto em 1837. Aquando da sua participação no projeto de Babbage, Ada desenvolveu os algoritmos que permitiriam à máquina computar os valores de funções matemáticas. Além disso, publicou uma coleção de notas sobre a ...

  14. On 'Money' in ISLM and AD/AS Models

    OpenAIRE

    Thomas K. Rymes; Colin Rogers

    2000-01-01

    Hicks's ISLM model interpretation of Keynes's theory is subject to much controversy. In this paper, we focus upon the 'real balance' effect and its role in ISLM and AD/AS analyses. We shall argue that ISLM and AD/AS require 'nominal anchors'. We live in a world where, increasingly, the 'money' in the ISLM and AD/AS model no longer exists (as Keynes imperfectly understood in his TREATISE ON MONEy). There are no longer any nominal anchors, rather they have been replaced by discretionary policy....

  15. Integrity and security in an Ada runtime environment

    Science.gov (United States)

    Bown, Rodney L.

    1991-01-01

    A review is provided of the Formal Methods group discussions. It was stated that integrity is not a pure mathematical dual of security. The input data is part of the integrity domain. The group provided a roadmap for research. One item of the roadmap and the final position statement are closely related to the space shuttle and space station. The group's position is to use a safe subset of Ada. Examples of safe sets include the Army Secure Operating System and the Penelope Ada verification tool. It is recommended that a conservative attitude is required when writing Ada code for life and property critical systems.

  16. CANDU 3 - Modularization

    International Nuclear Information System (INIS)

    McAskie, M.J.

    1991-01-01

    The CANDU 3 Heavy Water Reactor is the newest design developed by AECL CANDU. It has set as a major objective, the achievement of significant reductions in both cost and schedule over previous designs. The basic construction strategy is to incorporate extensive modularization of the plant in order to parallel the civil and mechanical installation works. This results in a target 38 month construction schedule from first concrete to in-service compared to 68 months for the Wolsong-1 CANDU 6 actually achieved and the 54 months envisaged for an improved CANDU 6. This paper describes the module concepts that have been developed and explains how they contribute to the overall construction program and achieve the desired cost and schedule targets set for the CANDU 3. (author). 7 figs, 2 tabs

  17. QUEST/Ada (Query Utility Environment for Software Testing of Ada): The development of a prgram analysis environment for Ada, task 1, phase 2

    Science.gov (United States)

    Brown, David B.

    1990-01-01

    The results of research and development efforts are described for Task one, Phase two of a general project entitled The Development of a Program Analysis Environment for Ada. The scope of this task includes the design and development of a prototype system for testing Ada software modules at the unit level. The system is called Query Utility Environment for Software Testing of Ada (QUEST/Ada). The prototype for condition coverage provides a platform that implements expert system interaction with program testing. The expert system can modify data in the instrument source code in order to achieve coverage goals. Given this initial prototype, it is possible to evaluate the rule base in order to develop improved rules for test case generation. The goals of Phase two are the following: (1) to continue to develop and improve the current user interface to support the other goals of this research effort (i.e., those related to improved testing efficiency and increased code reliable); (2) to develop and empirically evaluate a succession of alternative rule bases for the test case generator such that the expert system achieves coverage in a more efficient manner; and (3) to extend the concepts of the current test environment to address the issues of Ada concurrency.

  18. Bahan pemutih gigi dengan sertifikat ADA/ISO (Tooth bleaching material with ADA/ISO certificate

    Directory of Open Access Journals (Sweden)

    Asti Meizarini

    2005-06-01

    Full Text Available Bleaching of teeth for cosmetic reasons is a popular aspect of cosmetic dentistry because patients realize the aesthetical benefits of these products. The dentist as a clinician's practitioner must be knowledgeable of the products and their application techniques. Bleaching materials which are safe and effective are the ADA accepted or manufactured by those which have already haved ISO certificate. Dentist must have enough knowledge about in-office bleaching prescribed for home-use bleaching including their contra indication and side effects, to advise the patients and provide effective bleaching services.

  19. Ada Integrated Environment III Computer Program Development Specification. Volume III. Ada Optimizing Compiler.

    Science.gov (United States)

    1981-12-01

    file.library-unit{.subunit).SYMAP Statement Map: library-file. library-unit.subunit).SMAP Type Map: 1 ibrary.fi le. 1 ibrary-unit{.subunit). TMAP The library...generator SYMAP Symbol Map code generator SMAP Updated Statement Map code generator TMAP Type Map code generator A.3.5 The PUNIT Command The P UNIT...Core.Stmtmap) NAME Tmap (Core.Typemap) END Example A-3 Compiler Command Stream for the Code Generator Texas Instruments A-5 Ada Optimizing Compiler

  20. Modular reconfigurable machines incorporating modular open architecture control

    CSIR Research Space (South Africa)

    Padayachee, J

    2008-01-01

    Full Text Available degrees of freedom on a single platform. A corresponding modular Open Architecture Control (OAC) system is presented. OAC overcomes the inflexibility of fixed proprietary automation, ensuring that MRMs provide the reconfigurability and extensibility...

  1. Modular robotics for playful physiotherapy

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop

    2009-01-01

    We developed modular robotic tiles to be used for playful physiotherapy, which is supposed to motivate patients to engage in and perform physical rehabilitation exercises. We tested the modular robotic tiles for an extensive period of time (3 years) in daily use in a hospital rehabilitation unit e.......g. for cardiac patients. Also, the tiles were tested for performing physical rehabilitation of stroke patients in their private home. In all pilot test cases qualitative feedback indicate that the patients find the playful use of modular robotic tiles engaging and motivating for them to perform...

  2. A report on NASA software engineering and Ada training requirements

    Science.gov (United States)

    Legrand, Sue; Freedman, Glenn B.; Svabek, L.

    1987-01-01

    NASA's software engineering and Ada skill base are assessed and information that may result in new models for software engineering, Ada training plans, and curricula are provided. A quantitative assessment which reflects the requirements for software engineering and Ada training across NASA is provided. A recommended implementation plan including a suggested curriculum with associated duration per course and suggested means of delivery is also provided. The distinction between education and training is made. Although it was directed to focus on NASA's need for the latter, the key relationships to software engineering education are also identified. A rationale and strategy for implementing a life cycle education and training program are detailed in support of improved software engineering practices and the transition to Ada.

  3. Adenosine-deaminase (ADA activity in Psoriasis (A Preliminary Study

    Directory of Open Access Journals (Sweden)

    S D Chaudhry

    1988-01-01

    Full Text Available Study of adenosine-deaminase activity ′in 23 patients hav-mg psoriasis compared with an equal number of healthy controls revealed significantly high ADA-activity in the psotiatic patients.

  4. Latvian PR people are world class / Ada Parr

    Index Scriptorium Estoniae

    Parr, Ada

    2004-01-01

    Suhtekorraldusfirma Porter Novelli rahvusvahelise partnerluse juht suhtekorralduse osatähtsuse kasvust ettevõtete äritegevuses, suhtekorraldusturu olukorrast ja teenuste kvaliteedi tasemest Baltimaades. Vt. samas: Ada Parr recommends

  5. GRASP/Ada: Graphical Representations of Algorithms, Structures, and Processes for Ada. The development of a program analysis environment for Ada: Reverse engineering tools for Ada, task 2, phase 3

    Science.gov (United States)

    Cross, James H., II

    1991-01-01

    The main objective is the investigation, formulation, and generation of graphical representations of algorithms, structures, and processes for Ada (GRASP/Ada). The presented task, in which various graphical representations that can be extracted or generated from source code are described and categorized, is focused on reverse engineering. The following subject areas are covered: the system model; control structure diagram generator; object oriented design diagram generator; user interface; and the GRASP library.

  6. Ada 9X Project Revision Request Report. Supplement 1

    Science.gov (United States)

    1990-01-01

    SYNCHRONIZATION POINTS OF A TASK DATE: August 8, 1989 NAME: Patrick de Bondeli ADDRESS: CR2A, 19 Avenue Dubonnet 92411 - COURBEVOIE - CEDEX, FRANCE TELEPHONE...to the parent task. Evaluating the attributes TERMINATED or CALLABLE - Giovini and Zucca (1986) consider them as synchronization points, but we do not...Elena. An Analysis of Ada Tasking December 1986. Companion paper of the Ada Formal Definition Sponsored by the European Commission. De Bondeli , Patrick

  7. An Ada environment for relativistic cross section calculations

    International Nuclear Information System (INIS)

    Nilsson, E.

    1990-01-01

    We have developed an Ada environment adapted to relativistic cross section calculations. Objects such as four-vectors, γ- matrices and propagators are defined as well as operations between these objects. In this environment matrix elements can be expressed in a compact and readable way as Ada code. Unpolarized cross sections are calculated numerically by explicitly summing and averaging over spins and polarizations. A short presentation of the technique is given

  8. Programming in a proposed 9X distributed Ada

    Science.gov (United States)

    Waldrop, Raymond S.; Volz, Richard A.; Goldsack, Stephen J.; Holzbach-Valero, A. A.

    1991-01-01

    The studies of the proposed Ada 9X constructs for distribution, now referred to as AdaPT are reported. The goals for this time period were to revise the chosen example scenario and to begin studying about how the proposed constructs might be implemented. The example scenario chosen is the Submarine Combat Information Center (CIC) developed by IBM for the Navy. The specification provided by IBM was preliminary and had several deficiencies. To address these problems, some changes to the scenario specification were made. Some of the more important changes include: (1) addition of a system database management function; (2) addition of a fourth processing unit to the standard resources; (3) addition of an operator console interface function; and (4) removal of the time synchronization function. To implement the CIC scenario in AdaPT, the decided strategy were publics, partitions, and nodes. The principle purpose for implementing the CIC scenario was to demonstrate how the AdaPT constructs interact with the program structure. While considering ways that the AdaPt constructs might be translated to Ada 83, it was observed that the partition construct could reasonably be modeled as an abstract data type. Although this gives a useful method of modeling partitions, it does not at all address the configuration aspects on the node construct.

  9. Examining the reliability of ADAS-Cog change scores.

    Science.gov (United States)

    Grochowalski, Joseph H; Liu, Ying; Siedlecki, Karen L

    2016-09-01

    The purpose of this study was to estimate and examine ways to improve the reliability of change scores on the Alzheimer's Disease Assessment Scale, Cognitive Subtest (ADAS-Cog). The sample, provided by the Alzheimer's Disease Neuroimaging Initiative, included individuals with Alzheimer's disease (AD) (n = 153) and individuals with mild cognitive impairment (MCI) (n = 352). All participants were administered the ADAS-Cog at baseline and 1 year, and change scores were calculated as the difference in scores over the 1-year period. Three types of change score reliabilities were estimated using multivariate generalizability. Two methods to increase change score reliability were evaluated: reweighting the subtests of the scale and adding more subtests. Reliability of ADAS-Cog change scores over 1 year was low for both the AD sample (ranging from .53 to .64) and the MCI sample (.39 to .61). Reweighting the change scores from the AD sample improved reliability (.68 to .76), but lengthening provided no useful improvement for either sample. The MCI change scores had low reliability, even with reweighting and adding additional subtests. The ADAS-Cog scores had low reliability for measuring change. Researchers using the ADAS-Cog should estimate and report reliability for their use of the change scores. The ADAS-Cog change scores are not recommended for assessment of meaningful clinical change.

  10. Habidite: viviendas modulares industrializadas

    Directory of Open Access Journals (Sweden)

    Gómez Jáuregui, V.

    2009-03-01

    Full Text Available This paper is an introduction to one of the most relevant constructive systems of the last years: The integral industrialized construction. This method, based on three-dimensional modules, produces buildings made mainly from spatial cells of big dimensions; these three-dimensional modules are fabricated entirely in factory and, once they are finished, they are carried out to the site, where they are assembled in an easy manner. Even though it’s not a totally new system (in fact, the precedents will also be mentioned in this essay, Habidite is very confident in backing this tendency and doing its part in order to obtain modular reinforced concrete buildings of extraordinary quality, with domotic implements totally integrated in the dwellings and a high degree of sustainability, eco-technology and energetic efficiency. Many advantages are exposed and explained, dealing with the optimization of the productive processes in construction by means of the most advanced technologies.En este artículo se realiza una breve introducción a uno de los sistemas constructivos que más auge está teniendo en los últimos años: la edificación industrializada integral. Realizado a base de módulos tridimensionales, es éste un método de construcción en el cual los edificios se conforman básicamente por medio de células espaciales de grandes dimensiones; estos módulos tridimensionales se elaboran íntegramente en fábrica y, una vez están totalmente terminados, se transportan a obra, donde son montados de forma sencilla y rápida. Aunque no es un sistema totalmente novedoso (de hecho sus antecedentes también serán tratados brevemente en este texto, Habidite apuesta fuertemente por esta tendencia y aporta su grano de arena para conseguir edificios modulares de hormigón armado de extraordinaria calidad, con implementos domóticos totalmente integrados en la vivienda y un alto grado de sostenibilidad, eco-tecnología y eficiencia energética. Se abordan

  11. The modularity of pollination networks

    DEFF Research Database (Denmark)

    Olesen, Jens Mogens; Bascompte, J.; Dupont, Yoko

    2007-01-01

    In natural communities, species and their interactions are often organized as nonrandom networks, showing distinct and repeated complex patterns. A prevalent, but poorly explored pattern is ecological modularity, with weakly interlinked subsets of species (modules), which, however, internally...... consist of strongly connected species. The importance of modularity has been discussed for a long time, but no consensus on its prevalence in ecological networks has yet been reached. Progress is hampered by inadequate methods and a lack of large datasets. We analyzed 51 pollination networks including...... almost 10,000 species and 20,000 links and tested for modularity by using a recently developed simulated annealing algorithm. All networks with >150 plant and pollinator species were modular, whereas networks with

  12. Modular Lego-Electronics

    KAUST Repository

    Shaikh, Sohail F.

    2017-10-24

    Electronic system components have thousands of individual field effect transistors (FETs) interconnected executing dedicated functions. Assembly yield of >80% will guarantee system failure since a single interconnect failure will result in undesired performance. Hence, a paradigm shift is needed in the self-assembly or integration of state-of-the-art integrated circuits (ICs) for a physically compliant system. Traditionally, most ICs share same geometry with only variations in dimensions and packaging. Here, a generic manufacturable method of converting state-of-the-art complementary metal oxide semiconductor-based ICs into modular Lego-electronics is shown with unique geometry that is physically identifiable to ease manufacturing and enhance throughput. Various geometries at the backside of the silicon die and on the destination site having the same geometry with relaxed dimension (up to 50 µm extra) allow targeted site binding like DNA assembly. Different geometries, angles, and heights for different modules provide a unique identity to each of the ICs. A two-level geometric combination presented here helps in maintaining the uniqueness of individual module to assemble at exact matching site like a perfect lock-and-key model. The assembled ICs offer uncompromised electrical performance, higher yield, and fabrication ease. In future, this method can further be expanded for fluidic assisted self-assembly.

  13. Further observations on associations between the ADA gene and past malaria morbidity in Sardinia.

    Science.gov (United States)

    Gloria-Bottini, Fulvia; Saccucci, Patrizia; Meloni, Gianfranco; Bottini, Egidio

    2014-01-01

    Adenosine Deaminase (ADA) contributes to the regulation of adenosine concentration and in turn to T cell activation. Genetic variability of ADA activity may have, therefore, an important role in resistance to malaria. Indeed, previous studies in Sardinia have shown a lower frequency of ADA1 *2 allele (associated with low ADA activity) in areas, where malaria was heavily endemic compared to areas where malaria was not endemic. We have now studied the ADA2 locus, another polymorphic site with two alleles ADA2 *1 and ADA2 *2 within the ADA gene. In the area of Oristano (where malaria was endemic in the past) 51 consecutive newborns and in the area of Nuoro (where malaria was not as endemic) 48 consecutive newborns were examined. ADA1 and ADA2 genotypes were determined by DNA analysis. The low frequency of the ADA1 *2 allele in the area where malaria was endemic is confirmed. The frequency of the ADA2 *2 allele is higher in Oristano than in Nuoro resulting in a higher frequency of the ADA1 *1/ADA2 *2 haplotype in Oristano as compared to Nuoro. This suggests a selective advantage of this haplotype in a malarial environment. The ADA gene shows other polymorphic sites further studies on their role in human adaptation to malaria could be rewarding. © 2014 Wiley Periodicals, Inc.

  14. Lectures on Hilbert modular varieties and modular forms

    CERN Document Server

    Goren, Eyal Z

    2001-01-01

    This book is devoted to certain aspects of the theory of p-adic Hilbert modular forms and moduli spaces of abelian varieties with real multiplication. The theory of p-adic modular forms is presented first in the elliptic case, introducing the reader to key ideas of N. M. Katz and J.-P. Serre. It is re-interpreted from a geometric point of view, which is developed to present the rudiments of a similar theory for Hilbert modular forms. The theory of moduli spaces of abelian varieties with real multiplication is presented first very explicitly over the complex numbers. Aspects of the general theory are then exposed, in particular, local deformation theory of abelian varieties in positive characteristic. The arithmetic of p-adic Hilbert modular forms and the geometry of moduli spaces of abelian varieties are related. This relation is used to study q-expansions of Hilbert modular forms, on the one hand, and stratifications of moduli spaces on the other hand. The book is addressed to graduate students and non-exper...

  15. Modular Stirling Radioisotope Generator

    Science.gov (United States)

    Schmitz, Paul C.; Mason, Lee S.; Schifer, Nicholas A.

    2016-01-01

    High-efficiency radioisotope power generators will play an important role in future NASA space exploration missions. Stirling Radioisotope Generators (SRGs) have been identified as a candidate generator technology capable of providing mission designers with an efficient, high-specific-power electrical generator. SRGs high conversion efficiency has the potential to extend the limited Pu-238 supply when compared with current Radioisotope Thermoelectric Generators (RTGs). Due to budgetary constraints, the Advanced Stirling Radioisotope Generator (ASRG) was canceled in the fall of 2013. Over the past year a joint study by NASA and the Department of Energy (DOE) called the Nuclear Power Assessment Study (NPAS) recommended that Stirling technologies continue to be explored. During the mission studies of the NPAS, spare SRGs were sometimes required to meet mission power system reliability requirements. This led to an additional mass penalty and increased isotope consumption levied on certain SRG-based missions. In an attempt to remove the spare power system, a new generator architecture is considered, which could increase the reliability of a Stirling generator and provide a more fault-tolerant power system. This new generator called the Modular Stirling Radioisotope Generator (MSRG) employs multiple parallel Stirling convertor/controller strings, all of which share the heat from the General Purpose Heat Source (GPHS) modules. For this design, generators utilizing one to eight GPHS modules were analyzed, which provided about 50 to 450 W of direct current (DC) to the spacecraft, respectively. Four Stirling convertors are arranged around each GPHS module resulting in from 4 to 32 Stirling/controller strings. The convertors are balanced either individually or in pairs, and are radiatively coupled to the GPHS modules. Heat is rejected through the housing/radiator, which is similar in construction to the ASRG. Mass and power analysis for these systems indicate that specific

  16. From modular invariants to graphs: the modular splitting method

    International Nuclear Information System (INIS)

    Isasi, E; Schieber, G

    2007-01-01

    We start with a given modular invariant M of a two-dimensional su-hat(n) k conformal field theory (CFT) and present a general method for solving the Ocneanu modular splitting equation and then determine, in a step-by-step explicit construction (1) the generalized partition functions corresponding to the introduction of boundary conditions and defect lines; (2) the quantum symmetries of the higher ADE graph G associated with the initial modular invariant M. Note that one does not suppose here that the graph G is already known, since it appears as a by-product of the calculations. We analyse several su-hat(3) k exceptional cases at levels 5 and 9

  17. Modular Power Standard for Space Explorations Missions

    Science.gov (United States)

    Oeftering, Richard C.; Gardner, Brent G.

    2016-01-01

    Future human space exploration will most likely be composed of assemblies of multiple modular spacecraft elements with interconnected electrical power systems. An electrical system composed of a standardized set modular building blocks provides significant development, integration, and operational cost advantages. The modular approach can also provide the flexibility to configure power systems to meet the mission needs. A primary goal of the Advanced Exploration Systems (AES) Modular Power System (AMPS) project is to establish a Modular Power Standard that is needed to realize these benefits. This paper is intended to give the space exploration community a "first look" at the evolving Modular Power Standard and invite their comments and technical contributions.

  18. Modular Software-Defined Radio

    Directory of Open Access Journals (Sweden)

    Rhiemeier Arnd-Ragnar

    2005-01-01

    Full Text Available In view of the technical and commercial boundary conditions for software-defined radio (SDR, it is suggestive to reconsider the concept anew from an unconventional point of view. The organizational principles of signal processing (rather than the signal processing algorithms themselves are the main focus of this work on modular software-defined radio. Modularity and flexibility are just two key characteristics of the SDR environment which extend smoothly into the modeling of hardware and software. In particular, the proposed model of signal processing software includes irregular, connected, directed, acyclic graphs with random node weights and random edges. Several approaches for mapping such software to a given hardware are discussed. Taking into account previous findings as well as new results from system simulations presented here, the paper finally concludes with the utility of pipelining as a general design guideline for modular software-defined radio.

  19. Modular invariance and stochastic quantization

    International Nuclear Information System (INIS)

    Ordonez, C.R.; Rubin, M.A.; Zwanziger, D.

    1989-01-01

    In Polyakov path integrals and covariant closed-string field theory, integration over Teichmueller parameters must be restricted by hand to a single modular region. This problem has an analog in Yang-Mills gauge theory---namely, the Gribov problem, which can be resolved by the method of stochastic gauge fixing. This method is here employed to quantize a simple modular-invariant system: the Polyakov point particle. In the limit of a large gauge-fixing force, it is shown that suitable choices for the functional form of the gauge-fixing force can lead to a restriction of Teichmueller integration to a single modular region. Modifications which arise when applying stochastic quantization to a system in which the volume of the orbits of the gauge group depends on a dynamical variable, such as a Teichmueller parameter, are pointed out, and the extension to Polyakov strings and covariant closed-string field theory is discussed

  20. Modularity in New Market Formation

    DEFF Research Database (Denmark)

    Sanchez, Ron; Hang, Chang Chieh

    2017-01-01

    In this paper we appraise the ways in which use of closed-system proprietary product architectures versus open-system modular product architectures is likely to influence the dynamics and trajectory of new product market formation. We compare the evolutions of new markets in China for gas......-powered two-wheeled vehicles (G2WVs) based (initially) on closed-system proprietary architectures and for electric-powered two-wheeled vehicles (E2WVs) based on open-system modular architectures. We draw on this comparison to suggest ways in which the use of the two different kinds of architectures...... as the basis for new kinds of products may result in very different patterns and speeds of new market formation. We then suggest some key implications of the different dynamics of market formation associated with open-system modular architectures for both the competence-based strategic management (CBSM...

  1. Modular assembly of optical nanocircuits

    Science.gov (United States)

    Shi, Jinwei; Monticone, Francesco; Elias, Sarah; Wu, Yanwen; Ratchford, Daniel; Li, Xiaoqin; Alù, Andrea

    2014-05-01

    A key element enabling the microelectronic technology advances of the past decades has been the conceptualization of complex circuits with versatile functionalities as being composed of the proper combination of basic ‘lumped’ circuit elements (for example, inductors and capacitors). In contrast, modern nanophotonic systems are still far from a similar level of sophistication, partially because of the lack of modularization of their response in terms of basic building blocks. Here we demonstrate the design, assembly and characterization of relatively complex photonic nanocircuits by accurately positioning a number of metallic and dielectric nanoparticles acting as modular lumped elements. The nanoparticle clusters produce the desired spectral response described by simple circuit rules and are shown to be dynamically reconfigurable by modifying the direction or polarization of impinging signals. Our work represents an important step towards extending the powerful modular design tools of electronic circuits into nanophotonic systems.

  2. Modular system design and evaluation

    CERN Document Server

    Levin, Mark Sh

    2015-01-01

    This book examines seven key combinatorial engineering frameworks (composite schemes consisting of algorithms and/or interactive procedures) for hierarchical modular (composite) systems. These frameworks are based on combinatorial optimization problems (e.g., knapsack problem, multiple choice problem, assignment problem, morphological clique problem), with the author’s version of morphological design approach – Hierarchical Morphological Multicritieria Design (HMMD) – providing a conceptual lens with which to elucidate the examples discussed. This approach is based on ordinal estimates of design alternatives for systems parts/components, however, the book also puts forward an original version of HMMD that is based on new interval multiset estimates for the design alternatives with special attention paid to the aggregation of modular solutions (system versions). The second part of ‘Modular System Design and Evaluation’ provides ten information technology case studies that enriches understanding of th...

  3. Ada Lovelace, a encantadora de números

    OpenAIRE

    Ibaldo, Adriana; Schwantes, Cíntia

    2017-01-01

    Ada Lovelace foi a única filha legítima de seu famoso pai, o poeta George Gordon, Lord Byron. Seus pais se divorciaram quando Ada tinha apenas meses de idade, e ela nunca o conheceu. Mais do que isso, ela foi educada para evitar que a hereditariedade de loucura, que sua mãe acreditava que ela estaria em risco de desenvolver, se manifestasse. Assim, ela teve uma extensa educação matemática. Sua vida se desenrolou dentro do esperável para uma mulher de sua classe social em sua época, com um dif...

  4. State prisons are covered by ADA, 7th Circuit rules.

    Science.gov (United States)

    1997-07-25

    Prison inmate [name removed] sued the Indiana Department of Corrections, claiming it violated the Americans with Disabilities Act (ADA) by denying him access to education programs, the library, and the dining hall because he is blind. The 7th U.S. Circuit Court of Appeals rejected the district court's decision to dismiss the case based on the grounds that the ADA does not apply to prison inmates. The court held that the Department of Corrections cannot exclude an inmate with a disability from prison programs unless the accommodation caused an undue burden on the system.

  5. GRASP/Ada (Graphical Representations of Algorithms, Structures, and Processes for Ada): The development of a program analysis environment for Ada. Reverse engineering tools for Ada, task 1, phase 2

    Science.gov (United States)

    Cross, James H., II

    1990-01-01

    The study, formulation, and generation of structures for Ada (GRASP/Ada) are discussed in this second phase report of a three phase effort. Various graphical representations that can be extracted or generated from source code are described and categorized with focus on reverse engineering. The overall goal is to provide the foundation for a CASE (computer-aided software design) environment in which reverse engineering and forward engineering (development) are tightly coupled. Emphasis is on a subset of architectural diagrams that can be generated automatically from source code with the control structure diagram (CSD) included for completeness.

  6. DNA repair by the Ada protein of E. coli

    International Nuclear Information System (INIS)

    Karran, P.; Hall, J.

    1988-01-01

    This paper discusses the Ada protein of E. coli which exemplifies the highly specialized nature of the enzymes which have evolved to repair DNA. According to the authors, this protein exhibits not only novel mechanistic features but also provides an apparently unique example of a strategy for controlling gene expression in E. coli. They report that knowledge of the properties and mode of action of the Ada protein has afforded insight into how human cells are affected by alkylating agents, including those used in chemotherapy

  7. Emergent interfaces for feature modularization

    CERN Document Server

    Ribeiro, Márcio; Brabrand, Claus

    2014-01-01

    Developers frequently introduce errors into software systems when they fail to recognise module dependencies. Using forty-three software families and Software Product Lines (SPLs), where the majority are commonly used in industrial practice, the authors reports on the feature modularization problem and provides a study of how often it may occur in practice. To solve the problem they present the concept of emergent feature modularization which aims to establish contracts between features to prevent developers from breaking other features when performing a maintenance task.

  8. Modular Firewalls for Storage Areas

    Science.gov (United States)

    Fedor, O. H.; Owens, L. J.

    1986-01-01

    Giant honeycomb structures assembled in modular units. Flammable materials stored in cells. Walls insulated with firebrick to prevent spread of fire among cells. Portable, modular barrier withstands heat of combustion for limited time and confines combustion products horizontally to prevent fire from spreading. Barrier absorbs heat energy by ablation and not meant to be reused. Designed to keep fires from spreading among segments of solid rocket propellant in storage, barrier erected between storage units of other flammable or explosive materials; tanks of petroleum or liquid natural gas. Barrier adequate for most industrial purposes.

  9. Inherent controllability in modular ALMRs

    International Nuclear Information System (INIS)

    Sackett, J.I.; Sevy, R.H.; Wei, T.Y.C.

    1989-01-01

    As part of recent development efforts on advanced reactor designs ANL has proposed the IFR (Integral Fast Reactor) concept. The IFR concept is currently being applied to modular sized reactors which would be built in multiple power paks together with an integrated fuel cycle facility. It has been amply demonstrated that the concept as applied to the modular designs has significant advantages in regard to ATWS transients. Attention is now being focussed on determining whether or not those advantages deriving from the traits of the IFR can be translated to the operational/DBA (design basis accident) class of transients. 5 refs., 3 figs., 3 tabs

  10. Modular nuclear fuel assembly rack

    International Nuclear Information System (INIS)

    Davis, C.J.

    1982-01-01

    A modular nuclear fuel assembly rack constructed of an array of identical cells, each cell constructed of a plurality of identical flanged plates. The unique assembly of the plates into a rigid rack provides a cellular compartment for nuclear fuel assemblies and a cavity between the cells for accepting neutron absorbing materials thus allowing a closely spaced array. The modular rack size can be easily adapted to conform with available storage space. U-shaped flanges at the edges of the plates are nested together at the intersection of four cells in the array. A bar is placed at the intersection to lock the cells together

  11. Domain-specific cognitive effects of tramiprosate in patients with mild to moderate Alzheimer's disease: ADAS-cog subscale results from the Alphase Study.

    Science.gov (United States)

    Saumier, D; Duong, A; Haine, D; Garceau, D; Sampalis, J

    2009-11-01

    Tramiprosate (homotaurine, ALZHEMEDTM) was recently investigated for its efficacy, safety and disease-modification effects in a Phase III clinical study in mild to moderate Alzheimer's disease (AD) patients (the Alphase study). The primary cognitive endpoint measure of that study was the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog). To characterize potential cognitive benefits of tramiprosate, the present study describes exploratory analyses performed on scores obtained from the specific ADAS-cog subscales in order to determine whether specific domains of cognition may be differentially affected by tramiprosate, which would not have been evident from the measure's total score. Multi-center, double-blind, randomized, placebo-controlled study. 67 investigative sites in the United States and Canada. A total of 1,052 patients were randomized. Patients were randomized to receive twice a day Placebo (n=353), tramiprosate 100 mg (n=352) and tramiprosate 150 mg (n=347). ADAS-cog assessments were conducted every three months over the 78-week study period. Exploratory analyses were performed by comparing ADAS-cog subscale scores between Placebo and each active treatment arm at each visit. The findings of this analysis revealed statistically significant differences or statistical trends in favour of tramiprosate on six ADAS-cog subscales, namely Following Commands, Language Comprehension, Ideational Praxis, Object Naming, Remembering Test Instructions, and Spoken Language Ability. Differences in favor of Placebo were only observed on the Constructional Praxis subscale. This exploratory analysis suggests that tramiprosate may have some benefit on memory, language and praxis skills in mild to moderate AD individuals. Future clinical studies of tramiprosate should include specialized neuropsychological tests to validate its effects within these cognitive domains.

  12. Modular envelopes, OSFT and nonsymmetric (non-$\\sum$) modular operads

    Czech Academy of Sciences Publication Activity Database

    Markl, Martin

    2016-01-01

    Roč. 10, č. 2 (2016), s. 775-809 ISSN 1661-6952 Institutional support: RVO:67985840 Keywords : open string * surface * modular completion Subject RIV: BA - General Mathematics Impact factor: 0.625, year: 2016 http://www.ems-ph.org/journals/show_abstract.php?issn=1661-6952&vol=10&iss=2&rank=12

  13. A modular interpretation of various cubic towers

    DEFF Research Database (Denmark)

    Anbar Meidl, Nurdagül; Bassa, Alp; Beelen, Peter

    2017-01-01

    In this article we give a Drinfeld modular interpretation for various towers of function fields meeting Zink's bound.......In this article we give a Drinfeld modular interpretation for various towers of function fields meeting Zink's bound....

  14. Safe and Efficient Support for Embeded Multi-Processors in ADA

    Science.gov (United States)

    Ruiz, Jose F.

    2010-08-01

    New software demands increasing processing power, and multi-processor platforms are spreading as the answer to achieve the required performance. Embedded real-time systems are also subject to this trend, but in the case of real-time mission-critical systems, the properties of reliability, predictability and analyzability are also paramount. The Ada 2005 language defined a subset of its tasking model, the Ravenscar profile, that provides the basis for the implementation of deterministic and time analyzable applications on top of a streamlined run-time system. This Ravenscar tasking profile, originally designed for single processors, has proven remarkably useful for modelling verifiable real-time single-processor systems. This paper proposes a simple extension to the Ravenscar profile to support multi-processor systems using a fully partitioned approach. The implementation of this scheme is simple, and it can be used to develop applications amenable to schedulability analysis.

  15. Reasoning and change management in modular ontologies

    NARCIS (Netherlands)

    Stuckenschmidt, Heiner; Klein, Michel

    2007-01-01

    The benefits of modular representations are well known from many areas of computer science. While in software engineering modularization is mainly a vehicle for supporting distributed development and re-use, in knowledge representation, the main goal of modularization is efficiency of reasoning. In

  16. Modular invariance of N=2 minimal models

    International Nuclear Information System (INIS)

    Sidenius, J.

    1991-01-01

    We prove modular covariance of one-point functions at one loop in the diagonal N=2 minimal superconformal models. We use the recently derived general formalism for computing arbitrary conformal blocks in these models. Our result should be sufficient to guarantee modular covariance at arbitrary genus. It is thus an important check on the general formalism which is not manifestly modular covariant. (orig.)

  17. A Modularized Counselor-Education Program.

    Science.gov (United States)

    Miller, Thomas V.; Dimattia, Dominic J.

    1978-01-01

    Counselor-education programs may be enriched through the use of modularized learning experiences. This article notes several recent articles on competency-based counselor education, the concepts of simulation and modularization, and describes the process of developing a modularized master's program at the University of Bridgeport in Connecticut.…

  18. Prospect of small modular reactor development

    International Nuclear Information System (INIS)

    Li Huailin; Zhu Qingyuan; Wang Suli; Xia Haihong

    2014-01-01

    Small modular reactor has the advantages of modular construction, enhanced safety/robustness from simplified designs, better ecomonic, clean and carbon free, compatible with the needs of smaller utilities and diversified application. In this paper, the prospect of small modular reactor is discussed from technology development status, constraints, economic. (authors)

  19. Integrity and change in modular ontologies

    NARCIS (Netherlands)

    Stuckenschmidt, Heiner; Klein, Michel

    2003-01-01

    The benefits of modular representations arc well known from many areas of computer science. In this paper, we concentrate on the benefits of modular ontologies with respect to local containment of terminological reasoning. We define an architecture for modular ontologies that supports local

  20. Modular networks with hierarchical organization

    Indian Academy of Sciences (India)

    Several networks occurring in real life have modular structures that are arranged in a hierarchical fashion. In this paper, we have proposed a model for such networks, using a stochastic generation method. Using this model we show that, the scaling relation between the clustering and degree of the nodes is not a necessary ...

  1. Modularity in Cancer Care Provision

    DEFF Research Database (Denmark)

    Gobbi, Chiara; Hsuan, Juliana

    2012-01-01

    The paper presents the findings of a case study research conducted within the Danish healthcare system aimed at analyzing how modularity is deployed in the process of delivery cancer care. Three cancer packages are presented into detailed describing the process of defining the diagnosis and treat...

  2. Hierarchy of modular graph identities

    International Nuclear Information System (INIS)

    D’Hoker, Eric; Kaidi, Justin

    2016-01-01

    The low energy expansion of Type II superstring amplitudes at genus one is organized in terms of modular graph functions associated with Feynman graphs of a conformal scalar field on the torus. In earlier work, surprising identities between two-loop graphs at all weights, and between higher-loop graphs of weights four and five were constructed. In the present paper, these results are generalized in two complementary directions. First, all identities at weight six and all dihedral identities at weight seven are obtained and proven. Whenever the Laurent polynomial at the cusp is available, the form of these identities confirms the pattern by which the vanishing of the Laurent polynomial governs the full modular identity. Second, the family of modular graph functions is extended to include all graphs with derivative couplings and worldsheet fermions. These extended families of modular graph functions are shown to obey a hierarchy of inhomogeneous Laplace eigenvalue equations. The eigenvalues are calculated analytically for the simplest infinite sub-families and obtained by Maple for successively more complicated sub-families. The spectrum is shown to consist solely of eigenvalues s(s−1) for positive integers s bounded by the weight, with multiplicities which exhibit rich representation-theoretic patterns.

  3. Physical Modeling Modular Boxes: PHOXES

    DEFF Research Database (Denmark)

    Gelineck, Steven; Serafin, Stefania

    2010-01-01

    This paper presents the development of a set of musical instruments, which are based on known physical modeling sound synthesis techniques. The instruments are modular, meaning that they can be combined in various ways. This makes it possible to experiment with physical interaction and sonic...

  4. Hierarchy of modular graph identities

    Energy Technology Data Exchange (ETDEWEB)

    D’Hoker, Eric; Kaidi, Justin [Mani L. Bhaumik Institute for Theoretical Physics, Department of Physics and Astronomy,University of California,Los Angeles, CA 90095 (United States)

    2016-11-09

    The low energy expansion of Type II superstring amplitudes at genus one is organized in terms of modular graph functions associated with Feynman graphs of a conformal scalar field on the torus. In earlier work, surprising identities between two-loop graphs at all weights, and between higher-loop graphs of weights four and five were constructed. In the present paper, these results are generalized in two complementary directions. First, all identities at weight six and all dihedral identities at weight seven are obtained and proven. Whenever the Laurent polynomial at the cusp is available, the form of these identities confirms the pattern by which the vanishing of the Laurent polynomial governs the full modular identity. Second, the family of modular graph functions is extended to include all graphs with derivative couplings and worldsheet fermions. These extended families of modular graph functions are shown to obey a hierarchy of inhomogeneous Laplace eigenvalue equations. The eigenvalues are calculated analytically for the simplest infinite sub-families and obtained by Maple for successively more complicated sub-families. The spectrum is shown to consist solely of eigenvalues s(s−1) for positive integers s bounded by the weight, with multiplicities which exhibit rich representation-theoretic patterns.

  5. Modular forms a classical approach

    CERN Document Server

    Cohen, Henri

    2017-01-01

    The theory of modular forms is a fundamental tool used in many areas of mathematics and physics. It is also a very concrete and "fun" subject in itself and abounds with an amazing number of surprising identities. This comprehensive textbook, which includes numerous exercises, aims to give a complete picture of the classical aspects of the subject, with an emphasis on explicit formulas. After a number of motivating examples such as elliptic functions and theta functions, the modular group, its subgroups, and general aspects of holomorphic and nonholomorphic modular forms are explained, with an emphasis on explicit examples. The heart of the book is the classical theory developed by Hecke and continued up to the Atkin-Lehner-Li theory of newforms and including the theory of Eisenstein series, Rankin-Selberg theory, and a more general theory of theta series including the Weil representation. The final chapter explores in some detail more general types of modular forms such as half-integral weight, Hilbert, Jacob...

  6. ADA Compliance and Accessibility of Fitness Facilities in Western Wisconsin.

    Science.gov (United States)

    Johnson, Marquell J; Stoelzle, Hannah Y; Finco, Kristi L; Foss, Sadie E; Carstens, Katie

    2012-01-01

    The study expands the research on fitness facility accessibility by determining how compliant fitness facilities in rural western Wisconsin were with Title III of the Americans with Disabilities Act (ADA). Comparisons were made with 4 other studies that were conducted in different geographical regions. The study also examined fitness professionals' disability knowledge and awareness. An ADA fitness facility compliance instrument and a fitness professional disability awareness survey were used. Direct observation and physical measurements were taken during on-site visits to 16 of 36 eligible fitness facilities in rural western Wisconsin. Ten fitness professionals from participating facilities completed an online survey. Frequencies were used to analyze the results. None of the participating facilities were in 100% compliance with ADA. Customer service desk (84%) and path of travel throughout the facility (72%) were the highest compliance areas. Telephone (6%) and locker rooms (32%) were the lowest compliance areas. No fitness professional was trained in wheelchair transfers and very few had received training in providing services to individuals with disabilities. Fitness facility accessibility remains a concern nationally. Continued efforts need to be made to raise the awareness of ADA compliance among fitness professionals across the United States, especially in rural areas where fitness facility availability is limited.

  7. Understanding road users’ expectations : an essential step for ADAS development.

    NARCIS (Netherlands)

    Houtenbos, M. Jagtman, H.M. Hagenzieker, M.P. Wieringa, P.A. & Hale, A.R.

    2006-01-01

    This article indicates the need for understanding road users’ expectations when developing Advanced Driver Assistance Systems (ADAS). Nowadays, technology allows more and more opportunities to provide road users with all sorts of information or even actively support aspects of the driving task.

  8. Older drivers and ADAS : which systems improve road safety?

    NARCIS (Netherlands)

    Davidse, R.J.

    2006-01-01

    In the coming decades, the number of older drivers that experiences difficulties in traffic as a result of functional limitations will strongly increase. Advanced Driver Assistance Systems (ADAS) could resolve some of these difficulties, by providing personal assistance in a road environment that

  9. Geophysical analysis for the Ada Tepe region (Bulgaria) - case study

    Science.gov (United States)

    Trifonova, Petya; Metodiev, Metodi; Solakov, Dimcho; Simeonova, Stela; Vatseva, Rumiana

    2013-04-01

    According to the current archeological investigations Ada Tepe is the oldest gold mine in Europe with Late Bronze and Early Iron age. It is a typical low-sulfidation epithermal gold deposit and is hosted in Maastrichtian-Paleocene sedimentary rocks above a detachment fault contact with underlying Paleozoic metamorphic rocks. Ada Tepe (25o.39'E; 41o.25'N) is located in the Eastern Rhodope unit. The region is highly segmented despite the low altitude (470-750 m) due to widespread volcanic and sediment rocks susceptible to torrential erosion during the cold season. Besides the thorough geological exploration focused on identifying cost-effective stocks of mineral resources, a detailed geophysical analysis concernig diferent stages of the gold extraction project was accomplished. We present the main results from the geophysical investigation aimed to clarify the complex seismotectonic setting of the Ada Tepe site region. The overall study methodology consists of collecting, reviewing and estimating geophysical and seismological information to constrain the model used for seismic hazard assessment of the area. Geophysical information used in the present work consists of gravity, geomagnetic and seismological data. Interpretation of gravity data is applied to outline the axes of steep gravity transitions marked as potential axes of faults, flexures and other structures of dislocation. Direct inverse techniques are also utilized to estimate the form and depth of anomalous sources. For the purposes of seismological investigation of the Ada Tepe site region an earthquake catalogue is compiled for the time period 510BC - 2011AD. Statistical parameters of seismicity - annual seismic rate parameter, ?, and the b-value of the Gutenberg-Richter exponential relation for Ada Tepe site region, are estimated. All geophysical datasets and derived results are integrated using GIS techniques ensuring interoperability of data when combining, processing and visualizing obtained

  10. Bundling Products and Services Through Modularization Strategies

    DEFF Research Database (Denmark)

    Bask, Anu; Hsuan, Juliana; Rajahonka, Mervi

    2012-01-01

    Modularity has been recognized as a powerful tool in improving the efficiency and management of product design and manufacturing. However, the integrated view on covering both, product and service modularity for product-service systems (PSS), is under researched. Therefore, in this paper our...... objective is to contribute to the PSS modularity. Thus, we describe configurations of PSSs and the bundling of products and services through modularization strategies. So far there have not been tools to analyze and determine the correct combinations of degrees of product and service modularities....

  11. RoboMusic with modular playware

    DEFF Research Database (Denmark)

    Falkenberg, Kasper; Bærendsen, Niels Kristian; Nielsen, Jacob

    2011-01-01

    Based on the concepts of RoboMusic and modular playware, we developed a system composed of modular playware devices which allow any user to perform music in a simple, interactive manner. The key features exploited in the modular playware approach are modularity, fl exibility, construction......, immediate feedback to stimulate engagement, creative exploration of play activities, and in some cases activity design by end-users (e.g., DJs). We exemplify the approach with the development of 11 rock genres and 6 pop music pieces for modular I-BLOCKS, which are exhibited and in daily use at the Rock Me...

  12. RoboMusic with Modular Playware

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop; Bærendsen, Niels Kristian; Nielsen, Jacob

    2010-01-01

    Based on the concepts of RoboMusic and Modular Playware, we developed a system composed of modular playware devices, which allow any user to perform music in a simple, interactive manner. The key features exploited from the Modular Playware approach are modularity, flexibility, and construction......, immediate feedback to stimulate engagement, creative exploration of play activities, and in some cases activity design by end-users (e.g. DJ’s). We exemplify the approach with the development of 11 rock genres and 6 pop music pieces for modular I-BLOCKS, which are exhibited and in daily use at the Rock Me...

  13. Alteration of the carboxyl-terminal domain of Ada protein influences its inducibility, specificity, and strength as a transcriptional activator.

    OpenAIRE

    Shevell, D E; LeMotte, P K; Walker, G C

    1988-01-01

    The ada gene of Escherichia coli K-12 encodes the regulatory protein for the adaptive response to alkylating agents. A set of plasmids carrying ordered deletions from the 3' end of the ada gene were isolated and characterized. These ada deletions encode fusion proteins that derive their amino termini from ada and their carboxyl termini from the downstream vector sequence that occurs before an in-frame stop codon. Several of these ada deletions encode Ada derivatives that constitutively activa...

  14. Validation study of the Alzheimer's disease assessment scale-cognitive subscale (ADAS-Cog) for the Portuguese patients with mild cognitive impairment and Alzheimer's disease.

    Science.gov (United States)

    Nogueira, Joana; Freitas, Sandra; Duro, Diana; Almeida, Jorge; Santana, Isabel

    2018-03-23

    The Alzheimer's disease assessment scale-Cognitive Subscale (ADAS-Cog) is a battery to assess cognitive performance in Alzheimer's disease (AD) and was developed according to the core characteristics of cognitive decline in AD: memory, language, praxis, constructive ability, and orientation. The aim of this study was to explore the diagnostic accuracy and discriminative capacity of the ADAS-Cog for Mild Cognitive Impairment (MCI) and AD, using cut-off points for the Portuguese population. The European Portuguese version of the ADAS-Cog was administrated to 650 participants, divided into a control group (n = 210), an MCI group (n = 240), and an AD group (n = 200). The clinical groups fulfilled standard international diagnostic criteria. Controls were healthy cognitive participants actively integrated in the community. The neuropsychological assessment protocol included the ADAS-Cog, the Mini Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), and the Adults and Older Adults Functional Assessment Inventory (IAFAI). The ADAS-Cog revealed good psychometric indicators, and the total scores were significantly different between the three groups (p  9 points (AUC = .835; sensitivity = 58% and specificity = 91%) and AD > 12 points (AUC = .996; sensitivity = 94% and specificity = 98%). Our findings confirmed the capacity of the ADAS-Cog total score to identify cognitive impairment in AD patients, with poor sensitivity for MCI, in a Portuguese cohort.

  15. Development of Software Tools for ADA Compliance Data Collection, Management, and Inquiry

    Science.gov (United States)

    2014-07-01

    In this NUTC research project, the UNR research team developed an iOS application (named NDOT ADA Data) to efficiently and intuitively collect ADA inventory data with iPhones or iPads. This tool was developed to facilitate NDOT ADA data collect...

  16. Development of the Korean version of Alzheimer's Disease Assessment Scale (ADAS-K).

    Science.gov (United States)

    Youn, J C; Lee, D Y; Kim, K W; Lee, J H; Jhoo, J H; Lee, K U; Ha, J; Woo, J I

    2002-09-01

    The purpose of this study was the development of the Korean Version of Alzheimer's Disease Assessment Scale (ADAS-K). ADAS-K was administrated to 84 AD patients as well as 105 non-demented control subjects. Three aspects of reliability were tested. To evaluate the validity of ADAS-K, discriminant validity and concurrent validity were tested. To evaluate the sensitivity of ADAS-K to disease severity, all subjects, AD patients and control subjects, were grouped by CDR scale and their mean scores on ADAS-K were compared. ADAS-K demonstrated high levels of reliability. Mean ADAS-K scores for AD patients were significantly different from the control group (p ADAS-K exhibited significant correlations with other tests and scales (range 0.45-0.85, p ADAS-K displayed high diagnostic efficacy and the optimal cut-off point was selected between 18/19. ADAS-K was able to discriminate the degree of AD severity according to CDR classification. Our results suggested that ADAS-K-cog was sensitive to very mild AD. We demonstrated that ADAS-K is a reliable and valid instrument not only for AD diagnosis but also for evaluation of its severity. Copyright 2002 John Wiley & Sons, Ltd.

  17. 78 FR 10263 - Proposed Collection; Comment Request for ADA Accommodations Request Packet

    Science.gov (United States)

    2013-02-13

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for ADA... the ADA Accommodations Packet. DATES: Written comments should be received on or before April 15, 2013...: ADA Accommodations Request Packet. OMB Number: 1545-2027. Abstract: Information is collected so that...

  18. 76 FR 31892 - Recordkeeping and Reporting Requirements Under Title VII, the ADA, and GINA

    Science.gov (United States)

    2011-06-02

    ... Requirements Under Title VII, the ADA, and GINA AGENCY: Equal Employment Opportunity Commission. ACTION: Notice... Civil Rights Act of 1964 (Title VII) and the Americans with Disabilities Act (ADA) to entities covered... the same record retention requirements under GINA that are imposed under Title VII and the ADA, i.e...

  19. 76 FR 79065 - Recordkeeping and Reporting Requirements Under Title VII, the ADA and GINA

    Science.gov (United States)

    2011-12-21

    ... Reporting Requirements Under Title VII, the ADA and GINA CFR Correction In Title 29 of the Code of Federal... title VII or section 107 of the ADA'' and add in their place the words ``section 709(c) of title VII, section 107 of the ADA, or section 207(a) of GINA'' wherever they appear in the following sections...

  20. 77 FR 36231 - Americans With Disabilities Act (ADA) and Architectural Barriers Act (ABA) Accessibility...

    Science.gov (United States)

    2012-06-18

    ...-0004] RIN 3014-AA39 Americans With Disabilities Act (ADA) and Architectural Barriers Act (ABA... (ADA) and Architectural Barriers Act (ABA) Accessibility Guidelines to specifically address emergency... ensure that newly constructed and altered emergency transportable housing units covered by the ADA or ABA...

  1. 78 FR 34095 - Adequacy Status of the Idaho, Northern Ada County PM10

    Science.gov (United States)

    2013-06-06

    ..., Northern Ada County PM 10 State Implementation Plan for Transportation Conformity Purposes AGENCY...), and volatile organic compounds (VOC) for the years 2008, 2015 and 2023 in the Northern Ada County PM... Northern Ada County. The EPA's finding was made pursuant to the adequacy review process for implementation...

  2. Functional requirements for design of the Space Ultrareliable Modular Computer (SUMC) system simulator

    Science.gov (United States)

    Curran, R. T.; Hornfeck, W. A.

    1972-01-01

    The functional requirements for the design of an interpretive simulator for the space ultrareliable modular computer (SUMC) are presented. A review of applicable existing computer simulations is included along with constraints on the SUMC simulator functional design. Input requirements, output requirements, and language requirements for the simulator are discussed in terms of a SUMC configuration which may vary according to the application.

  3. Modular Stellarator Fusion Reactor concept

    International Nuclear Information System (INIS)

    Miller, R.L.; Krakowski, R.A.

    1981-08-01

    A preliminary conceptual study is made of the Modular Stellarator Reactor (MSR). A steady-state ignited, DT-fueled, magnetic fusion reactor is proposed for use as a central electric-power station. The MSR concept combines the physics of the classic stellarator confinement topology with an innovative, modular-coil design. Parametric tradeoff calculations are described, leading to the selection of an interim design point for a 4-GWt plant based on Alcator transport scaling and an average beta value of 0.04 in an l = 2 system with a plasma aspect ratio of 11. The physics basis of the design point is described together with supporting magnetics, coil-force, and stress computations. The approach and results presented herein will be modified in the course of ongoing work to form a firmer basis for a detailed conceptual design of the MSR

  4. CP violation and modular symmetries

    OpenAIRE

    Dent, Thomas

    2001-01-01

    We reconsider the origin of CP violation in fundamental theory. Existing string models of spontaneous CP violation make ambiguous predictions, due to the arbitrariness of CP transformation and the apparent non-invariance of the results under duality. We find an unambiguous modular CP invariance condition, applicable to predictive models of spontaneous CP violation, which circumvents these problems; it strongly constrains CP violation by heterotic string moduli. The dilaton is also evaluated a...

  5. Modularity in Sensory Auditory Memory

    OpenAIRE

    Clement, Sylvain; Moroni, Christine; Samson, Séverine

    2004-01-01

    The goal of this paper was to review various experimental and neuropsychological studies that support the modular conception of auditory sensory memory or auditory short-term memory. Based on initial findings demonstrating that verbal sensory memory system can be dissociated from a general auditory memory store at the functional and anatomical levels. we reported a series of studies that provided evidence in favor of multiple auditory sensory stores specialized in retaining eit...

  6. A Modular Instant Messaging System

    OpenAIRE

    Mohamad Raad; Zouhair Bazzal; Majd Ghareeb; Hanan Farhat; Semar Bahmad

    2017-01-01

    Instant Messaging (IM) Android applications are a trend nowadays. These applications are categorized according to their features: usability, flexibility, privacy and security. However, IM applications tend to be inflexible in terms of functionality offered. The “Dble-U” system was developed as a solution to this inflexibility, with a focus on privacy as an example use case. “Dble-U” is a configurable modular system consisting of an Android chatting application, a privacy controller applicatio...

  7. CAMAC modular programmable function generator

    Energy Technology Data Exchange (ETDEWEB)

    Turner, G.W.; Suehiro, S.; Hendricks, R.W.

    1980-12-01

    A CAMAC modular programmable function generator has been developed. The device contains a 1024 word by 12-bit memory, a 12-bit digital-to-analog converter with a 600 ns settling time, an 18-bit programmable frequency register, and two programmable trigger output registers. The trigger registers can produce programmed output logic transitions at various (binary) points in the output function curve, and are used to synchronize various other data acquisition devices with the function curve.

  8. CAMAC modular programmable function generator

    International Nuclear Information System (INIS)

    Turner, G.W.; Suehiro, S.; Hendricks, R.W.

    1980-12-01

    A CAMAC modular programmable function generator has been developed. The device contains a 1024 word by 12-bit memory, a 12-bit digital-to-analog converter with a 600 ns settling time, an 18-bit programmable frequency register, and two programmable trigger output registers. The trigger registers can produce programmed output logic transitions at various (binary) points in the output function curve, and are used to synchronize various other data acquisition devices with the function curve

  9. Ada Compiler Validation Summary Report: Certificate Number 890711W1. 10109 Concurrent Computer Corporation C(3) Ada, Version R02-02.00 Concurrent Computer Corporation 3280 MPS

    Science.gov (United States)

    1989-07-11

    Wright-Patterson ATB Dayton, OH, USA Ada Joint Prograr Office United States De artment of Defense " * ’ , Washington, DC 2 301-3061 i4. I 10 k A$ -h-Y...dependent but is permitted by the Ada Standard. Six classes of tests are used. These tests are designed to perform checks at compile time, at link time...the direction of the AVF according to procedures establizhed by the Ada Joia ,, Program Office and administered by the Ada Validation Organization (AVO

  10. Enabling Concise and Modular Specifications in Separation Logic

    DEFF Research Database (Denmark)

    Jensen, Jonas Buhrkal

    2014-01-01

    logics and examples of using these logics to verify challenging programs. The article Modular Verification of Linked Lists with Views via Separation Logic reports on verification of a practical data structure with separation logic. The challenges identified in this work has served as motivation for later...... unstructured control flow and the lack of basic facilities in the language such as memory allocation and procedure calls. Finally, the chapter Techniques for Model Construction in Separation Logic surveys the mathematical techniques used to develop the previous separation logics and many other logics...

  11. Seismic calculation of buildings using a modular programme system

    International Nuclear Information System (INIS)

    Meskouris, K.; Weber, B.

    1980-01-01

    The calculation of the stress resultant and of the deformation forces affecting a building during an earthquake is shown here by two examples ( a multi-span bridge and a high multistage frame), the calculation being made in accordance with DIN E 4149 of December 1976, using the modular programme MISS-SMIS. In contrast to the usual programme systems, it is the user who determines the required algorithm with the aid of a mnemonic language and a collection of independent programme parts (modules). Thus, simple adjustment to the individual tasks to be carried out together with a high degree of transparency and flexibility of the calculation process is achieved. (orig.) [de

  12. Modular programming method at JAERI

    International Nuclear Information System (INIS)

    Asai, Kiyoshi; Katsuragi, Satoru

    1982-02-01

    In this report the histories, concepts and a method for the construction and maintenance of nuclear code systems of Japan Atomic Energy Research Institute (JAERI) are presented. The method is mainly consisted of novel computer features. The development process of the features and experiences with them which required many man-months and efforts of scientists and engineers of JAERI and a computer manufacturer are also described. One of the features is a file handling program named datapool. The program is being used in code systems which are under development at JAERI. The others are computer features such as dynamic linking, reentrant coding of Fortran programs, interactive programming facility, document editor, quick system output viewer and editor, flexible man-machine interactive Fortran executor, and selective use of time-sharing or batch oriented computer in an interactive porgramming environment. In 1980 JAERI has replaced its two old computer systems by three FACOM M-200 computer systems and they have such features as mentioned above. Since 1981 most code systems, or even big single codes can be changed to modular code systems even if the developers or users of the systems will not recognize the fact that they are using modular code systems. The purpose of this report is to describe our methodology of modular programming from aspects of computer features and some of their applications to nuclear codes to get sympathetic understanding of it from persons of organizations who are concerned with the effective use of computers, especially, in nuclear research fields. (author)

  13. A high proportion of ADA point mutations associated with a specific alanine-to-valine substitution.

    OpenAIRE

    Markert, M L; Norby-Slycord, C; Ward, F E

    1989-01-01

    In 15%-20% of children with severe combined immunodeficiency (SCID), the underlying defect is adenosine deaminase (ADA) deficiency. The overall goal of our research has been to identify the precise molecular defects in patients with ADA-deficient SCID. In this study, we focused on a patient whom we found to have normal sized ADA mRNA by Northern analysis and an intact ADA structural gene by Southern analysis. By cloning and sequencing this patient's ADA cDNA, we found a C-to-T point mutation ...

  14. Self-organized modularization in evolutionary algorithms.

    Science.gov (United States)

    Dauscher, Peter; Uthmann, Thomas

    2005-01-01

    The principle of modularization has proven to be extremely successful in the field of technical applications and particularly for Software Engineering purposes. The question to be answered within the present article is whether mechanisms can also be identified within the framework of Evolutionary Computation that cause a modularization of solutions. We will concentrate on processes, where modularization results only from the typical evolutionary operators, i.e. selection and variation by recombination and mutation (and not, e.g., from special modularization operators). This is what we call Self-Organized Modularization. Based on a combination of two formalizations by Radcliffe and Altenberg, some quantitative measures of modularity are introduced. Particularly, we distinguish Built-in Modularity as an inherent property of a genotype and Effective Modularity, which depends on the rest of the population. These measures can easily be applied to a wide range of present Evolutionary Computation models. It will be shown, both theoretically and by simulation, that under certain conditions, Effective Modularity (as defined within this paper) can be a selection factor. This causes Self-Organized Modularization to take place. The experimental observations emphasize the importance of Effective Modularity in comparison with Built-in Modularity. Although the experimental results have been obtained using a minimalist toy model, they can lead to a number of consequences for existing models as well as for future approaches. Furthermore, the results suggest a complex self-amplification of highly modular equivalence classes in the case of respected relations. Since the well-known Holland schemata are just the equivalence classes of respected relations in most Simple Genetic Algorithms, this observation emphasizes the role of schemata as Building Blocks (in comparison with arbitrary subsets of the search space).

  15. Administration and scoring variance on the ADAS-Cog.

    Science.gov (United States)

    Connor, Donald J; Sabbagh, Marwan N

    2008-11-01

    The Alzheimer's Disease Assessment Scale - Cognitive (ADAS-Cog) is the most commonly used primary outcome instrument in clinical trials for treatments of dementia. Variations in forms, administration procedures and scoring rules, along with rater turnover and intra-rater drift may decrease the reliability of the instrument. A survey of possible variations in the ADAS-Cog was administered to 26 volunteer raters at a clinical trials meeting. Results indicate notable protocol variations in the forms used, administration procedures, and scoring rules. Since change over time is used to determine treatment effect in clinical trials, standardizing the instrument's ambiguities and addressing common problems will greatly increase the instrument's reliability and thereby enhance its sensitivity to treatment effects.

  16. Software/hardware distributed processing network supporting the Ada environment

    Science.gov (United States)

    Wood, Richard J.; Pryk, Zen

    1993-09-01

    A high-performance, fault-tolerant, distributed network has been developed, tested, and demonstrated. The network is based on the MIPS Computer Systems, Inc. R3000 Risc for processing, VHSIC ASICs for high speed, reliable, inter-node communications and compatible commercial memory and I/O boards. The network is an evolution of the Advanced Onboard Signal Processor (AOSP) architecture. It supports Ada application software with an Ada- implemented operating system. A six-node implementation (capable of expansion up to 256 nodes) of the RISC multiprocessor architecture provides 120 MIPS of scalar throughput, 96 Mbytes of RAM and 24 Mbytes of non-volatile memory. The network provides for all ground processing applications, has merit for space-qualified RISC-based network, and interfaces to advanced Computer Aided Software Engineering (CASE) tools for application software development.

  17. Olimpíadas e geopolítica

    Directory of Open Access Journals (Sweden)

    João Fábio Bertonha

    2008-09-01

    Full Text Available

    o artigo trata de competições esportivas,

    em especial as olimpíadas. Nelas, valorizam-se o

    nacionalismo e o poder dos países.

  18. Bernoulli Numbers: from Ada Lovelace to the Debye Functions

    OpenAIRE

    Sparavigna , Amelia Carolina

    2016-01-01

    Jacob Bernoulli owes his fame for the numerous contributions to calculus and for his discoveries in the field of probability. Here we will discuss one of his contributions to the theory of numbers, the Bernoulli numbers. They were proposed as a case study by Ada Lovelace in her analysis of Menabrea's report on Babbage Analytical Engine. It is probable that it was this Lovelace's work, that inspired Hans Thirring in using the Bernoulli numbers in the calculus of the Debye functions.

  19. The Synergy Between PAV and AdaBoost

    OpenAIRE

    WILBUR, W. JOHN; YEGANOVA, LANA; KIM, WON

    2005-01-01

    Schapire and Singer’s improved version of AdaBoost for handling weak hypotheses with confidence rated predictions represents an important advance in the theory and practice of boosting. Its success results from a more efficient use of information in weak hypotheses during updating. Instead of simple binary voting a weak hypothesis is allowed to vote for or against a classification with a variable strength or confidence. The Pool Adjacent Violators (PAV) algorithm is a method for converting a ...

  20. Overfitting Reduction of Text Classification Based on AdaBELM

    Directory of Open Access Journals (Sweden)

    Xiaoyue Feng

    2017-07-01

    Full Text Available Overfitting is an important problem in machine learning. Several algorithms, such as the extreme learning machine (ELM, suffer from this issue when facing high-dimensional sparse data, e.g., in text classification. One common issue is that the extent of overfitting is not well quantified. In this paper, we propose a quantitative measure of overfitting referred to as the rate of overfitting (RO and a novel model, named AdaBELM, to reduce the overfitting. With RO, the overfitting problem can be quantitatively measured and identified. The newly proposed model can achieve high performance on multi-class text classification. To evaluate the generalizability of the new model, we designed experiments based on three datasets, i.e., the 20 Newsgroups, Reuters-21578, and BioMed corpora, which represent balanced, unbalanced, and real application data, respectively. Experiment results demonstrate that AdaBELM can reduce overfitting and outperform classical ELM, decision tree, random forests, and AdaBoost on all three text-classification datasets; for example, it can achieve 62.2% higher accuracy than ELM. Therefore, the proposed model has a good generalizability.

  1. Chagas Parasite Detection in Blood Images Using AdaBoost

    Directory of Open Access Journals (Sweden)

    Víctor Uc-Cetina

    2015-01-01

    Full Text Available The Chagas disease is a potentially life-threatening illness caused by the protozoan parasite, Trypanosoma cruzi. Visual detection of such parasite through microscopic inspection is a tedious and time-consuming task. In this paper, we provide an AdaBoost learning solution to the task of Chagas parasite detection in blood images. We give details of the algorithm and our experimental setup. With this method, we get 100% and 93.25% of sensitivity and specificity, respectively. A ROC comparison with the method most commonly used for the detection of malaria parasites based on support vector machines (SVM is also provided. Our experimental work shows mainly two things: (1 Chagas parasites can be detected automatically using machine learning methods with high accuracy and (2 AdaBoost + SVM provides better overall detection performance than AdaBoost or SVMs alone. Such results are the best ones known so far for the problem of automatic detection of Chagas parasites through the use of machine learning, computer vision, and image processing methods.

  2. ADA perceived disability claims: a decision-tree analysis.

    Science.gov (United States)

    Draper, William R; Hawley, Carolyn E; McMahon, Brian T; Reid, Christine A; Barbir, Lara A

    2014-06-01

    The purpose of this study is to examine the possible interactions of predictor variables pertaining to perceived disability claims contained in a large governmental database. Specifically, it is a retrospective analysis of US Equal Employment Opportunity Commission (EEOC) data for the entire population of workplace discrimination claims based on the "regarded as disabled" prong of the Americans with Disabilities Act (ADA) definition of disability. The study utilized records extracted from a "master database" of over two million charges of workplace discrimination in the Integrated Mission System of the EEOC. This database includes all ADA-related discrimination allegations filed from July 26, 1992 through December 31, 2008. Chi squared automatic interaction detection (CHAID) was employed to analyze interaction effects of relevant variables, such as issue (grievance) and industry type. The research question addressed by CHAID is: What combination of factors are associated with merit outcomes for people making ADA EEOC allegations who are "regarded as" having disabilities? The CHAID analysis shows how merit outcome is predicted by the interaction of relevant variables. Issue was found to be the most prominent variable in determining merit outcome, followed by industry type, but the picture is made more complex by qualifications regarding age and race data. Although discharge was the most frequent grievance among charging parties in the perceived disability group, its merit outcome was significantly less than that for the leading factor of hiring.

  3. Modular control system for embedded applications

    Directory of Open Access Journals (Sweden)

    Dostálek Petr

    2016-01-01

    Full Text Available This paper deals with hardware design of a modular control system intended for embedded applications demanding high computational power while maintaining low cost. The control system central unit is based on 32bit microcontroller MK60DN512 with ARM Cortex-M4 core manufactured by NXP Semiconductor. Module provides all the necessary signals on the two 2-row 40 pin headers and Ethernet communication interface in the form of a small daughter board. It is connected to the mainboard which must always contain 5 V stabilized power supply; other circuits are application specific. In our application the mainboard is equipped with SD card slot, RS232 and RS485 interface which is used for high speed interconnection with up to 15 expansion peripheral modules. This concept enables high flexibility to specific application demands without necessity of redesigning the control system. Controller is freely programmable in C language using any compatible integrated development environment – NXP Kinetis Design Studio, for example. Software development and debugging is simplified by our support program libraries including necessary routines for control and monitoring tasks.

  4. Modular representation of layered neural networks.

    Science.gov (United States)

    Watanabe, Chihiro; Hiramatsu, Kaoru; Kashino, Kunio

    2018-01-01

    Layered neural networks have greatly improved the performance of various applications including image processing, speech recognition, natural language processing, and bioinformatics. However, it is still difficult to discover or interpret knowledge from the inference provided by a layered neural network, since its internal representation has many nonlinear and complex parameters embedded in hierarchical layers. Therefore, it becomes important to establish a new methodology by which layered neural networks can be understood. In this paper, we propose a new method for extracting a global and simplified structure from a layered neural network. Based on network analysis, the proposed method detects communities or clusters of units with similar connection patterns. We show its effectiveness by applying it to three use cases. (1) Network decomposition: it can decompose a trained neural network into multiple small independent networks thus dividing the problem and reducing the computation time. (2) Training assessment: the appropriateness of a trained result with a given hyperparameter or randomly chosen initial parameters can be evaluated by using a modularity index. And (3) data analysis: in practical data it reveals the community structure in the input, hidden, and output layers, which serves as a clue for discovering knowledge from a trained neural network. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Modular properties of 6d (DELL) systems

    Science.gov (United States)

    Aminov, G.; Mironov, A.; Morozov, A.

    2017-11-01

    If super-Yang-Mills theory possesses the exact conformal invariance, there is an additional modular invariance under the change of the complex bare charge [InlineMediaObject not available: see fulltext.]. The low-energy Seiberg-Witten prepotential ℱ( a), however, is not explicitly invariant, because the flat moduli also change a - → a D = ∂ℱ/∂ a. In result, the prepotential is not a modular form and depends also on the anomalous Eisenstein series E 2. This dependence is usually described by the universal MNW modular anomaly equation. We demonstrate that, in the 6 d SU( N) theory with two independent modular parameters τ and \\widehat{τ} , the modular anomaly equation changes, because the modular transform of τ is accompanied by an ( N -dependent!) shift of \\widehat{τ} and vice versa. This is a new peculiarity of double-elliptic systems, which deserves further investigation.

  6. Modular Design in Treaty Verification Equipment

    Energy Technology Data Exchange (ETDEWEB)

    Macarthur, Duncan Whittemore [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Benz, Jacob [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Tolk, Keith [Milagro Consulting, Albuquerque, NM (United States); Weber, Tom [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-01-27

    It is widely believed that modular design is a good thing. However, there are often few explicit arguments, or even an agreed range of definitions, to back up this belief. In this paper, we examine the potential range of design modularity, the implications of various amounts of modularity, and the advantages and disadvantages of each level of modular construction. We conclude with a comparison of the advantages and disadvantages of each type, as well as discuss many caveats that should be observed to take advantage of the positive features of modularity and minimize the effects of the negative. The tradeoffs described in this paper will be evaluated during the conceptual design to determine what amount of modularity should be included.

  7. Modular Robotics in an African Context

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop

    2011-01-01

    In this paper, we review the concept, development and use of modular robotic devices for education, health improvements, and business in Africa. The modular robotics inspired technology has the advantage of allowing any user easy access to a physical construction of new and advanced technology. We...... conceptualized several educational tools inspired by modular robotics for contextualized IT education in Tanzania, leading to a novel IT degree program and the development of East Africa’s first science and business park in Iringa, Tanzania. The prototypes inspired by modular robotics were developed in the local......, rural context and tested by local users in hospitals and rehabilitation centres. In this paper, we review the development of both modular building blocks for education and modular robotic tiles for rehabilitation in Tanzania....

  8. (Automated) software modularization using community detection

    DEFF Research Database (Denmark)

    Hansen, Klaus Marius; Manikas, Konstantinos

    2015-01-01

    The modularity of a software system is known to have an effect on, among other, development effort, change impact, and technical debt. Modularizing a specific system and evaluating this modularization is, however, challenging. In this paper, we apply community detection methods to the graph...... of class dependencies in software systems to find optimal modularizations through communities. We evaluate this approach through a study of 111 Java systems contained in the Qualitas Corpus. We found that using the modularity function of Newman with an Erdős-Rényi null-model and using the community...... detection algorithm of Reichardt and Bornholdt improved community quality for all systems, that coupling decreased for 99 of the systems, and that coherence increased for 102 of the systems. Furthermore, the modularity function correlates with existing metrics for coupling and coherence....

  9. Epitope characterization of the ADA response directed against a targeted immunocytokine.

    Science.gov (United States)

    Stubenrauch, Kay; Künzel, Christian; Vogel, Rudolf; Tuerck, Dietrich; Schick, Eginhard; Heinrich, Julia

    2015-10-10

    Targeted immunocytokines (TICs) display potent activity in selective tumor suppression. This class of multi domain biotherapeutics (MDBs) is composed of the three major domains Fab, Fc, and a cytokine which may induce a complex polyclonal anti-drug antibody (ADA) response. However, classical ADA assays usually are not suitable to specify ADAs and to identify the immunogenic domains of a TIC. The purpose of the present study was to establish epitope characterization of ADA responses in order to specify immunogenic responses against a TIC and their direct impact on the pharmacokinetic profile, safety, and efficacy. Based on standard ADA screening and confirmation assays, respectively, domain detection assays (DDAs) and domain competition assays (DCAs) were established and compared by the use of 12 ADA-positive samples obtained from a cynomolgus monkey study in early development. Both domain-specific assays were sensitive enough to preserve the positive screening assay result and revealed an overall accordance for the evaluation of domain-specific ADA responses. About half of the samples displayed one ADA specificity, either for the Fab or for the cytokine (Cy) domain, and the remaining samples showed a combination of Fab-specific and Cy-specific ADA fractions. Fc-specific ADAs occurred in only one sample. In-depth comparison of DCAs and DDAs showed that both assays appeared to be appropriate to assess multi-specific ADA responses as well as minor ADA fractions. An advantage of DCAs is typically a fast and easy assay establishment, whereas, DDAs in some cases may be superior to assess low abundant ADAs in multi-specific responses. Our results reveal that both approaches benefit from thorough reagent development as an essential precondition for reliable epitope characterization of ADA responses. Copyright © 2015 Elsevier B.V. All rights reserved.

  10. Programming languages for circuit design.

    Science.gov (United States)

    Pedersen, Michael; Yordanov, Boyan

    2015-01-01

    This chapter provides an overview of a programming language for Genetic Engineering of Cells (GEC). A GEC program specifies a genetic circuit at a high level of abstraction through constraints on otherwise unspecified DNA parts. The GEC compiler then selects parts which satisfy the constraints from a given parts database. GEC further provides more conventional programming language constructs for abstraction, e.g., through modularity. The GEC language and compiler is available through a Web tool which also provides functionality, e.g., for simulation of designed circuits.

  11. Anomalies and modular invariance in string theory

    International Nuclear Information System (INIS)

    Schellekens, A.N.; Warner, N.P.

    1986-01-01

    All known anomaly cancellations of heterotic string theories are derived directly from one-loop modular invariance, and are shown to be related to a property of modular functions of weight 2. Using modular invariance infinite classes of anomaly free field theories are constructed in (8m+2) dimensions for any m. A generating function is obtained for the anomalies of string-related field theories in (8m+2) dimensions. (orig.)

  12. KWU's modular approach to HTR commercialization

    International Nuclear Information System (INIS)

    Frewer, H.; Weisbrodt, I.

    1983-01-01

    As a way of avoiding the uncertainties, delays and unacceptable commercial risks which have plagued advanced reactor projects in Germany, KWU is advocating a modular approach to commercialization of the high-temperature reactor (HTR), using small size standard reactor units. KWU has received a contract for the study of a co-generation plant based on this modular system. Features of the KWU modular HTR, process heat, gasification, costs and future development are discussed. (UK)

  13. Identification of drivers for modular production

    DEFF Research Database (Denmark)

    Brunoe, Thomas Ditlev; Bossen, Jacob; Nielsen, Kjeld

    2015-01-01

    Todays competitive environment in industry creates a need for companies to enhance their ability to introduce new products faster. To increase rampup speed reconfigurable manufacturing systems is a promising concept, however to implement this production platforms and modular manufacturing...... is required. This paper presents an analysis whether and which module drivers from general product development can be applied to the development process of a modular manufacturing system. The result is a compiled list of modular drivers for manufacturing and examples of their use....

  14. The modular high temperature gas cooled reactor

    International Nuclear Information System (INIS)

    Lutz, D.E.; Lipps, A.J.

    1984-01-01

    Due to relatively high operating temperatures, the gas-cooled reactor has the potential to serve a wide variety of energy applications. This paper discusses the energy applications which can be served by the modular HTGR, the magnitude of the potential markets, and the HTGR product cost incentives relative to fossil fuel competition. Advantages of the HTGR modular systems are presented along with a description of the design features and performance characteristics of the current reference HTGR modular systems

  15. Modular invariance, chiral anomalies and contact terms

    International Nuclear Information System (INIS)

    Kutasov, D.

    1988-03-01

    The chiral anomaly in heterotic strings with full and partial modular invariance in D=2n+2 dimensions is calculated. The boundary terms which were present in previous calculations are shown to be cancelled in the modular invariant case by contact terms, which can be obtained by an appropriate analytic continuation. The relation to the low energy field theory is explained. In theories with partial modular invariance, an expression for the anomaly is obtained and shown to be non zero in general. (author)

  16. Banana Algebra: Compositional syntactic language extension

    DEFF Research Database (Denmark)

    Andersen, Jacob; Brabrand, Claus; Christiansen, David Raymond

    2013-01-01

    We propose an algebra of languages and transformations as a means of compositional syntactic language extension. The algebra provides a layer of high-level abstractions built on top of languages (captured by context-free grammars) and transformations (captured by constructive catamorphisms...... algebra as presented in the paper is implemented as the Banana Algebra Tool which may be used to syntactically extend languages in an incremental and modular fashion via algebraic composition of previously defined languages and transformations. We demonstrate and evaluate the tool via several kinds...

  17. Disrupted modular organization of primary sensory brain areas in schizophrenia

    Directory of Open Access Journals (Sweden)

    Cécile Bordier

    Full Text Available Abnormal brain resting-state functional connectivity has been consistently observed in patients affected by schizophrenia (SCZ using functional MRI and other neuroimaging techniques. Graph theoretical methods provide a framework to investigate these defective functional interactions and their effects on the organization of brain connectivity networks. A few studies have shown altered distribution of connectivity within and between functional modules in SCZ patients, an indication of imbalanced functional segregation ad integration. However, no major alterations of modular organization have been reported in patients, and unambiguous identification of the neural substrates affected remains elusive. Recently, it has been demonstrated that current modularity analysis methods suffer from a fundamental and severe resolution limit, as they fail to detect features that are smaller than a scale determined by the size of the entire connectivity network. This resolution limit is likely to have hampered the ability to resolve differences between patients and controls in previous studies. Here, we apply Surprise, a novel resolution limit-free approach, to study the modular organization of resting state functional connectivity networks in a large cohort of SCZ patients and in matched healthy controls. Leveraging these important methodological advances we find new evidence of substantial fragmentation and reorganization involving primary sensory, auditory and visual areas in SCZ patients. Conversely, frontal and prefrontal areas, typically associated with higher cognitive functions, appear to be largely unaffected, with changes selectively involving language and speech processing areas. Our findings support the hypothesis that cognitive dysfunction in SCZ may involve deficits occurring already at early stages of sensory processing. Keywords: Schizophrenia, Surprise, Asymptotical surprise, Functional connectivity, Community detection, Modularity, Graph theory

  18. Modular Structures in a Multinational Force Headquarters

    National Research Council Canada - National Science Library

    Stewart, K; Christie, M

    2004-01-01

    .... It is proposed that future Multinational Force (MNF) military headquarters (HQ) can achieve this flexibility through a modular organizational structure enabled by networked information management and communication technologies...

  19. A Modular SOS for Action Notation - Revisited

    DEFF Research Database (Denmark)

    Mosses, Peter David

    A draft modular SOS for the new version of AN, referred to as AN-2, has been available since 2000. It is written in CASL and has been checked for well-formedness using CATS (CASL Tool Set). It appears to be significantly more accessible than the original SOS of AN-1. However, it now appears......-notation for the modular SOS rules. After discussing the issues, we look at some illustrative examples taken from an improved modular SOS of AN-2 (in preparation). We also look at the possibility of empirical testing of the modular SOS by a straightforward translation to Prolog....

  20. Problems in the theory of modular forms

    CERN Document Server

    Murty, M Ram; Graves, Hester

    2016-01-01

    This book introduces the reader to the fascinating world of modular forms through a problem-solving approach. As such, besides researchers, the book can be used by the undergraduate and graduate students for self-instruction. The topics covered include q-series, the modular group, the upper half-plane, modular forms of level one and higher level, the Ramanujan τ-function, the Petersson inner product, Hecke operators, Dirichlet series attached to modular forms and further special topics. It can be viewed as a gentle introduction for a deeper study of the subject. Thus, it is ideal for non-experts seeking an entry into the field. .

  1. Towards a Standard for Modular Petri Nets

    DEFF Research Database (Denmark)

    Kindler, Ekkart; Petrucci, Laure

    2009-01-01

    concepts could or should be subject to import and export in high-level Petri nets. In this paper, we formalise a minimal version of modular high-level Petri nets, which is based on the concepts of modular PNML. This shows that modular PNML can be formalised once a specific version of Petri net is fixed....... Moreover, we present and discuss some more advanced features of modular Petri nets that could be included in the standard. This way, we provide a formal foundation and a basis for a discussion of features to be included in the upcoming standard of a module concept for Petri nets in general and for high-level...

  2. Decentralizing decision making in modularization strategies

    DEFF Research Database (Denmark)

    Israelsen, Poul; Jørgensen, Brian

    2011-01-01

    which distorts the economic effects of modularization at the level of the individual product. This has the implication that decisions on modularization can only be made by top management if decision authority and relevant information are to be aligned. To overcome this problem, we suggest a solution...... that aligns the descriptions of the economic consequences of modularization at the project and portfolio level which makes it possible to decentralize decision making while making sure that local goals are congruent with the global ones in order to avoid suboptimal behaviour. Keywords: Modularization......; Accounting; Cost allocation; Decision rule; Decentralization...

  3. On modular stellarator reactor coils

    International Nuclear Information System (INIS)

    Rau, F.; Harmeyer, E.; Kisslinger, J.; Wobig, H.

    1985-01-01

    Modular twisted coils are discussed which produce magnetic fields of the Advanced Stellarator WENDELSTEIN VII-AS type. Reducing the number coils/FP offers advantage for maintenance of coils, but increases the magnetic ripple and B m /B o . Computation of force densities within the coils of ASR and ASB yield local maximum values of about 80 and 180 MN/m 3 , respectively. A system of mutual coil support is being developed. Twisted coils in helical arrangement provide a reactor-sized HELIAC system. In order to reduce the magnetic ripple, a large number of 14 coils/FP in special arrangement is used

  4. Functional annotation of hierarchical modularity.

    Directory of Open Access Journals (Sweden)

    Kanchana Padmanabhan

    Full Text Available In biological networks of molecular interactions in a cell, network motifs that are biologically relevant are also functionally coherent, or form functional modules. These functionally coherent modules combine in a hierarchical manner into larger, less cohesive subsystems, thus revealing one of the essential design principles of system-level cellular organization and function-hierarchical modularity. Arguably, hierarchical modularity has not been explicitly taken into consideration by most, if not all, functional annotation systems. As a result, the existing methods would often fail to assign a statistically significant functional coherence score to biologically relevant molecular machines. We developed a methodology for hierarchical functional annotation. Given the hierarchical taxonomy of functional concepts (e.g., Gene Ontology and the association of individual genes or proteins with these concepts (e.g., GO terms, our method will assign a Hierarchical Modularity Score (HMS to each node in the hierarchy of functional modules; the HMS score and its p-value measure functional coherence of each module in the hierarchy. While existing methods annotate each module with a set of "enriched" functional terms in a bag of genes, our complementary method provides the hierarchical functional annotation of the modules and their hierarchically organized components. A hierarchical organization of functional modules often comes as a bi-product of cluster analysis of gene expression data or protein interaction data. Otherwise, our method will automatically build such a hierarchy by directly incorporating the functional taxonomy information into the hierarchy search process and by allowing multi-functional genes to be part of more than one component in the hierarchy. In addition, its underlying HMS scoring metric ensures that functional specificity of the terms across different levels of the hierarchical taxonomy is properly treated. We have evaluated our

  5. CP violation and modular symmetries

    International Nuclear Information System (INIS)

    Dent, Thomas

    2001-01-01

    We reconsider the origin of CP violation in fundamental theory. Existing string models of spontaneous CP violation make ambiguous predictions, due to the arbitrariness of CP transformation and the apparent noninvariance of the results under duality. We find a modular CP invariance condition, applicable to any predictive model of spontaneous CP violation, which circumvents these problems; it strongly constrains CP violation by heterotic string moduli. The dilaton is also evaluated as a source of CP violation, but is likely experimentally excluded. We consider the prospects for explaining CP violation in strongly coupled strings and brane worlds

  6. The Language Grid: supporting intercultural collaboration

    Science.gov (United States)

    Ishida, T.

    2018-03-01

    A variety of language resources already exist online. Unfortunately, since many language resources have usage restrictions, it is virtually impossible for each user to negotiate with every language resource provider when combining several resources to achieve the intended purpose. To increase the accessibility and usability of language resources (dictionaries, parallel texts, part-of-speech taggers, machine translators, etc.), we proposed the Language Grid [1]; it wraps existing language resources as atomic services and enables users to create new services by combining the atomic services, and reduces the negotiation costs related to intellectual property rights [4]. Our slogan is “language services from language resources.” We believe that modularization with recombination is the key to creating a full range of customized language environments for various user communities.

  7. Transcriptional Adaptor ADA3 of Drosophila melanogaster Is Required for Histone Modification, Position Effect Variegation, and Transcription▿ †

    OpenAIRE

    Grau, Benjamin; Popescu, Cristina; Torroja, Laura; Ortuño-Sahagún, Daniel; Boros, Imre; Ferrús, Alberto

    2007-01-01

    The Drosophila melanogaster gene diskette (also known as dik or dAda3) encodes a protein 29% identical to human ADA3, a subunit of GCN5-containing histone acetyltransferase (HAT) complexes. The fly dADA3 is a major contributor to oogenesis, and it is also required for somatic cell viability. dADA3 localizes to chromosomes, and it is significantly reduced in dGcn5 and dAda2a, but not in dAda2b, mutant backgrounds. In dAda3 mutants, acetylation at histone H3 K9 and K14, but not K18, and at hist...

  8. Decentralized and Modular Electrical Architecture

    Science.gov (United States)

    Elisabelar, Christian; Lebaratoux, Laurence

    2014-08-01

    This paper presents the studies made on the definition and design of a decentralized and modular electrical architecture that can be used for power distribution, active thermal control (ATC), standard inputs-outputs electrical interfaces.Traditionally implemented inside central unit like OBC or RTU, these interfaces can be dispatched in the satellite by using MicroRTU.CNES propose a similar approach of MicroRTU. The system is based on a bus called BRIO (Bus Réparti des IO), which is composed, by a power bus and a RS485 digital bus. BRIO architecture is made with several miniature terminals called BTCU (BRIO Terminal Control Unit) distributed in the spacecraft.The challenge was to design and develop the BTCU with very little volume, low consumption and low cost. The standard BTCU models are developed and qualified with a configuration dedicated to ATC, while the first flight model will fly on MICROSCOPE for PYRO actuations and analogue acquisitions. The design of the BTCU is made in order to be easily adaptable for all type of electric interface needs.Extension of this concept is envisaged for power conditioning and distribution unit, and a Modular PCDU based on BRIO concept is proposed.

  9. Modular plants for small deposits

    International Nuclear Information System (INIS)

    Josa, J.M.; Moral, A.; Otero, J.L.; Suarez, E.

    1985-01-01

    The large investment required to recover uranium from small deposits is the greatest obstacle to their economic development. Various concepts (caravan mill, pure mill or semimobile mill) have been elaborated in different countries. Studies have also been made in Spain to develop a simple and economic flowsheet suitable for the beneficiation of small uranium deposits. An acid heap-leaching and solvent extraction process was chosen because there is already a great deal of experience of it in Spain. Modifications were necessary to make the equipment easy to transport and also to have a low and reusable investment when this flowsheet is used for small deposits. The aim was to develop a modular plant with all the elements fitted in compact units that needs little site preparation and little time and effort to connect the units. A standard small portable crushing plant can be borrowed and the mining operation and heap construction can be put to contract. There is a solvent extraction unit (150 m 3 /d) in continuous operation (24 h/d) and concentrate precipitation and handling facilities. The whole of the equipment is standard and as light as possible. Little civil engineering is required and the erection of the plant only needs a few months. The uranium capacity of these modular plants is between 35 and 50 t U 3 O 8 /a. Special consideration has been paid to regulations and the environmental aspects. (author)

  10. Hydraulic Modular Dosaging Systems for Machine Drives

    Directory of Open Access Journals (Sweden)

    A. J. Kotlobai

    2005-01-01

    Full Text Available The justified principle of making modular dosaging systems for positive-displacement multimotor hydraulic drives used in running gear and technological equipment of mobile construction, road and agricultural machines makes it possible to synchronize motion of running parts. The examples of the realization of modular dosaging systems and an algorithm of their operation are given in the paper.

  11. Theta function identities associated with Ramanujan's modular ...

    Indian Academy of Sciences (India)

    In Chapter 20 of his second notebook [6], Ramanujan recorded several theta function identities associated with modular equations of composite degree 15. These identities have previously been proved by Berndt in [3]. But he proved most of these theta function identities using modular equations. These identities can also ...

  12. Modular bootstrap in Liouville field theory

    International Nuclear Information System (INIS)

    Hadasz, Leszek; Jaskolski, Zbigniew; Suchanek, Paulina

    2010-01-01

    The modular matrix for the generic 1-point conformal blocks on the torus is expressed in terms of the fusion matrix for the 4-point blocks on the sphere. The modular invariance of the toric 1-point functions in the Liouville field theory with DOZZ structure constants is proved.

  13. Modular bootstrap in Liouville field theory

    Energy Technology Data Exchange (ETDEWEB)

    Hadasz, Leszek, E-mail: hadasz@th.if.uj.edu.p [M. Smoluchowski Institute of Physics, Jagiellonian University, Reymonta 4, 30-059 Krakow (Poland); Jaskolski, Zbigniew, E-mail: jask@ift.uni.wroc.p [Institute of Theoretical Physics, University of Wroclaw, pl. M. Borna, 50-204 Wroclaw (Poland); Suchanek, Paulina, E-mail: paulina@ift.uni.wroc.p [Institute of Theoretical Physics, University of Wroclaw, pl. M. Borna, 50-204 Wroclaw (Poland)

    2010-02-22

    The modular matrix for the generic 1-point conformal blocks on the torus is expressed in terms of the fusion matrix for the 4-point blocks on the sphere. The modular invariance of the toric 1-point functions in the Liouville field theory with DOZZ structure constants is proved.

  14. Modular bootstrap in Liouville field theory

    Science.gov (United States)

    Hadasz, Leszek; Jaskólski, Zbigniew; Suchanek, Paulina

    2010-02-01

    The modular matrix for the generic 1-point conformal blocks on the torus is expressed in terms of the fusion matrix for the 4-point blocks on the sphere. The modular invariance of the toric 1-point functions in the Liouville field theory with DOZZ structure constants is proved.

  15. Curriculum Development through YTS Modular Credit Accumulation.

    Science.gov (United States)

    Further Education Unit, London (England).

    This document reports the evaluation of the collaborately developed Modular Training Framework (MainFrame), a British curriculum development project, built around a commitment to a competency-based, modular credit accumulation program. The collaborators were three local education authorities (LEAs), those of Bedfordshire, Haringey, and Sheffield,…

  16. Higher-order (non-)modularity

    DEFF Research Database (Denmark)

    Appel, Claus; van Oostrom, Vincent; Simonsen, Jakob Grue

    2010-01-01

    We show that, contrary to the situation in first-order term rewriting, almost none of the usual properties of rewriting are modular for higher-order rewriting, irrespective of the higher-order rewriting format. We show that for the particular format of simply typed applicative term rewriting...... systems modularity of confluence, normalization, and termination can be recovered by imposing suitable linearity constraints....

  17. Modular interdependency in complex dynamical systems.

    Science.gov (United States)

    Watson, Richard A; Pollack, Jordan B

    2005-01-01

    Herbert A. Simon's characterization of modularity in dynamical systems describes subsystems as having dynamics that are approximately independent of those of other subsystems (in the short term). This fits with the general intuition that modules must, by definition, be approximately independent. In the evolution of complex systems, such modularity may enable subsystems to be modified and adapted independently of other subsystems, whereas in a nonmodular system, modifications to one part of the system may result in deleterious side effects elsewhere in the system. But this notion of modularity and its effect on evolvability is not well quantified and is rather simplistic. In particular, modularity need not imply that intermodule dependences are weak or unimportant. In dynamical systems this is acknowledged by Simon's suggestion that, in the long term, the dynamical behaviors of subsystems do interact with one another, albeit in an "aggregate" manner--but this kind of intermodule interaction is omitted in models of modularity for evolvability. In this brief discussion we seek to unify notions of modularity in dynamical systems with notions of how modularity affects evolvability. This leads to a quantifiable measure of modularity and a different understanding of its effect on evolvability.

  18. Analytic properties of the Virasoro modular kernel

    Energy Technology Data Exchange (ETDEWEB)

    Nemkov, Nikita [Moscow Institute of Physics and Technology (MIPT), Dolgoprudny (Russian Federation); Institute for Theoretical and Experimental Physics (ITEP), Moscow (Russian Federation); National University of Science and Technology MISIS, The Laboratory of Superconducting metamaterials, Moscow (Russian Federation)

    2017-06-15

    On the space of generic conformal blocks the modular transformation of the underlying surface is realized as a linear integral transformation. We show that the analytic properties of conformal block implied by Zamolodchikov's formula are shared by the kernel of the modular transformation and illustrate this by explicit computation in the case of the one-point toric conformal block. (orig.)

  19. Modularity and its effects on innovation

    DEFF Research Database (Denmark)

    Boer, Henrike Engele Elisabeth; Hansen, Poul H. Kyvsgård

    systematic work and management type of tasks, although it conflicts with the typical characteristics associated with the entrepreneur. If not managed properly, modularization can foster the modularity trap over time. At this stage intrapreneurial activities can help the organization stay ahead of the game...

  20. Syntactic Language Extension via an Algebra of Languages and Transformations

    DEFF Research Database (Denmark)

    Andersen, Jacob; Brabrand, Claus

    2010-01-01

    We propose an algebra of languages and transformations as a means for extending languages syntactically. The algebra provides a layer of high-level abstractions built on top of languages (captured by context-free grammars) and transformations (captured by constructive catamorphisms). The algebra...... is self-contained in that any term of the algebra specifying a transformation can be reduced to a catamorphism, before the transformation is run. Thus, the algebra comes “for free” without sacrificing the strong safety and efficiency properties of constructive catamorphisms. The entire algebra...... as presented in the paper is implemented as the Banana Algebra Tool which may be used to syntactically extend languages in an incremental and modular fashion via algebraic composition of previously defined languages and transformations. We demonstrate and evaluate the tool via several kinds of extensions....

  1. Distributed Issues for Ada Real-Time Systems

    Science.gov (United States)

    1990-07-23

    NUMBERS Distributed Issues for Ada Real - Time Systems MDA 903-87- C- 0056 S. AUTHOR(S) Thomas E. Griest 7. PERFORMING ORGANiZATION NAME(S) AND ADORESS(ES) 8...considerations. I Adding to the problem of distributed real - time systems is the issue of maintaining a common sense of time among all of the processors...because -omeone is waiting for the final output of a very large set of computations. However in real - time systems , consistent meeting of short-term

  2. An Overview of Advanced Data Acquisition System (ADAS)

    Science.gov (United States)

    Mata, Carlos T.; Steinrock, T. (Technical Monitor)

    2001-01-01

    The paper discusses the following: 1. Historical background. 2. What is ADAS? 3. R and D status. 4. Reliability/cost examples (1, 2, and 3). 5. What's new? 6. Technical advantages. 7. NASA relevance. 8. NASA plans/options. 9. Remaining R and D. 10. Applications. 11. Product benefits. 11. Commercial advantages. 12. intellectual property. Aerospace industry requires highly reliable data acquisition systems. Traditional Acquisition systems employ end-to-end hardware and software redundancy. Typically, redundancy adds weight, cost, power consumption, and complexity.

  3. Adenosine Deaminase (ADA)-Deficient Severe Combined Immune Deficiency (SCID): Molecular Pathogenesis and Clinical Manifestations.

    Science.gov (United States)

    Bradford, Kathryn L; Moretti, Federico A; Carbonaro-Sarracino, Denise A; Gaspar, Hubert B; Kohn, Donald B

    2017-10-01

    Deficiency of adenosine deaminase (ADA, EC3.5.4.4), a housekeeping enzyme of purine metabolism encoded by the Ada gene, is a cause of human severe combined immune deficiency (SCID). Numerous deleterious mutations occurring in the ADA gene have been found in patients with profound lymphopenia (T - B - NK - ), thus underscoring the importance of functional purine metabolism for the development of the immune defense. While untreated ADA SCID is a fatal disorder, there are multiple life-saving therapeutic modalities to restore ADA activity and reconstitute protective immunity, including enzyme replacement therapy (ERT), allogeneic hematopoietic stem cell transplantation (HSCT) and gene therapy (GT) with autologous gene-corrected hematopoietic stem cells (HSC). We review the pathogenic mechanisms and clinical manifestations of ADA SCID.

  4. Maternal T-cell engraftment impedes with diagnosis of a SCID-ADA patient.

    Science.gov (United States)

    Lanfranchi, Arnalda; Lougaris, Vassilios; Notarangelo, Lucia Dora; Soncini, Elena; Comini, Marta; Beghin, Alessandra; Bolda, Federica; Montanelli, Alessandro; Imberti, Luisa; Porta, Fulvio

    2018-02-02

    We describe the case of a child affected by severe combined immunodeficiency (SCID) with adenosine deaminase (ADA) deficiency showing a maternal T-cell engraftment, a finding that has never been reported before. The presence of engrafted maternal T cells was misleading. Although ADA enzymatic levels were suggestive of ADA-SCID, the child did not present the classical signs of ADA deficiency; therefore, the initial diagnosis was of a conventional SCID. However, ADA toxic metabolites and molecular characterization confirmed this diagnosis. Polyethylene glycol-modified bovine (PEG) ADA therapy progressively decreased the number of maternal engrafted T cells. The child was grafted with full bone marrow from a matched unrelated donor, after a reduced conditioning regimen, and the result was the complete immunological reconstitution. Copyright © 2018 Elsevier Inc. All rights reserved.

  5. A Formal Theory for Modular ERDF Ontologies

    Science.gov (United States)

    Analyti, Anastasia; Antoniou, Grigoris; Damásio, Carlos Viegas

    The success of the Semantic Web is impossible without any form of modularity, encapsulation, and access control. In an earlier paper, we extended RDF graphs with weak and strong negation, as well as derivation rules. The ERDF #n-stable model semantics of the extended RDF framework (ERDF) is defined, extending RDF(S) semantics. In this paper, we propose a framework for modular ERDF ontologies, called modular ERDF framework, which enables collaborative reasoning over a set of ERDF ontologies, while support for hidden knowledge is also provided. In particular, the modular ERDF stable model semantics of modular ERDF ontologies is defined, extending the ERDF #n-stable model semantics. Our proposed framework supports local semantics and different points of view, local closed-world and open-world assumptions, and scoped negation-as-failure. Several complexity results are provided.

  6. Modular Product Families and Assembly Systems

    DEFF Research Database (Denmark)

    Thyssen, Jesper

    2005-01-01

    This research centres on assembly systems designed for utilizing product modularization. Altogether, the task for companies has become an issue of managing the overall trade-off between the external market’s desire for variety and the internal efficiency and effectiveness. Product modularization...... a number of theoretical and managerial implications are identified. From a management point of view, the most im-portant finding is that modularization needs to be configured for the two competitive situations, i.e. 1) the volume flexible configuration focusing on generational product variety and 2......) the mix flexible con-figuration focusing on the simultaneous product variety. These two views are in particular different in respect to the understanding of product modularization. All in all, modularization needs to be, and can be, configured in regard to the specific task, which is believed constituting...

  7. Enablers & Barriers for Realizing Modularity Benefits

    DEFF Research Database (Denmark)

    Storbjerg, Simon Haahr; Brunø, Thomas Ditlev; Thyssen, Jesper

    2012-01-01

    far less attention compared to the theories and methods concerning modularization of technical systems. Harvesting the full potential of modularization, particularly in relation to product development agility, depends on more than an optimal architecture. Key enablers in this context......Although modularization is becoming both a well-described domain in academia and a broadly applied concept in business, many of today’s firm still struggle to realize the promised benefits of this approach. Managing modularization is a complex matter, and in spite of this, a topic that has received...... are the organizational and systems related aspects. Recognizing the need for guidance to realize the benefits of modularity, the purpose of this study is through a literature study and a case study to improve the insight into the organizational and systems related enablers and barriers with regard to obtaining the full...

  8. Language Contact.

    Science.gov (United States)

    Nelde, Peter Hans

    1995-01-01

    Examines the phenomenon of language contact and recent trends in linguistic contact research, which focuses on language use, language users, and language spheres. Also discusses the role of linguistic and cultural conflicts in language contact situations. (13 references) (MDM)

  9. Small Modular Reactors: Institutional Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Joseph Perkowski, Ph.D.

    2012-06-01

    ? Objectives include, among others, a description of the basic development status of “small modular reactors” (SMRs) focused primarily on domestic activity; investigation of the domestic market appeal of modular reactors from the viewpoints of both key energy sector customers and also key stakeholders in the financial community; and consideration of how to proceed further with a pro-active "core group" of stakeholders substantially interested in modular nuclear deployment in order to provide the basis to expedite design/construction activity and regulatory approval. ? Information gathering was via available resources, both published and personal communications with key individual stakeholders; published information is limited to that already in public domain (no confidentiality); viewpoints from interviews are incorporated within. Discussions at both government-hosted and private-hosted SMR meetings are reflected herein. INL itself maintains a neutral view on all issues described. Note: as per prior discussion between INL and CAP, individual and highly knowledgeable senior-level stakeholders provided the bulk of insights herein, and the results of those interviews are the main source of the observations of this report. ? Attachment A is the list of individual stakeholders consulted to date, including some who provided significant earlier assessments of SMR institutional feasibility. ? Attachments B, C, and D are included to provide substantial context on the international status of SMR development; they are not intended to be comprehensive and are individualized due to the separate nature of the source materials. Attachment E is a summary of the DOE requirements for winning teams regarding the current SMR solicitation. Attachment F deserves separate consideration due to the relative maturity of the SMART SMR program underway in Korea. Attachment G provides illustrative SMR design features and is intended for background. Attachment H is included for overview

  10. Review guidelines for software languages for use in nuclear power plant safety systems: Final report. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Hecht, M.; Decker, D.; Graff, S.; Green, W.; Lin, D.; Dinsmore, G.; Koch, S. [SoHaR, Inc., Beverly Hills, CA (United States)

    1997-10-01

    Guidelines for the programming and auditing of software written in high level languages for safety systems are presented. The guidelines are derived from a framework of issues significant to software safety which was gathered from relevant standards and research literature. Language-specific adaptations of these guidelines are provided for the following high level languages: Ada83 and Ada95; C and C++; International Electrochemical Commission (IEC) Standard 1131-3 Ladder Logic, Sequential Function Charts, Structured Text, and Function Block Diagrams; Pascal; and PL/M. Appendices to the report include a tabular summary of the guidelines and additional information on selected languages.

  11. Review guidelines for software languages for use in nuclear power plant safety systems: Final report. Revision 1

    International Nuclear Information System (INIS)

    Hecht, M.; Decker, D.; Graff, S.; Green, W.; Lin, D.; Dinsmore, G.; Koch, S.

    1997-10-01

    Guidelines for the programming and auditing of software written in high level languages for safety systems are presented. The guidelines are derived from a framework of issues significant to software safety which was gathered from relevant standards and research literature. Language-specific adaptations of these guidelines are provided for the following high level languages: Ada83 and Ada95; C and C++; International Electrochemical Commission (IEC) Standard 1131-3 Ladder Logic, Sequential Function Charts, Structured Text, and Function Block Diagrams; Pascal; and PL/M. Appendices to the report include a tabular summary of the guidelines and additional information on selected languages

  12. Cutting Fat or Removing the Brain: Is the Divisional ADA Battalion Headquarters Necessary?

    National Research Council Canada - National Science Library

    Sauter, Daniel

    1998-01-01

    .... This monograph examines whether the divisional ADA battalion headquarters, an intermediate headquarters, is necessary to command and control divisional air defense operations in a Force XXI environment...

  13. Analytical performances of the Diazyme ADA assay on the Cobas® 6000 system.

    Science.gov (United States)

    Delacour, Hervé; Sauvanet, Christophe; Ceppa, Franck; Burnat, Pascal

    2010-12-01

    To evaluate the analytical performance of the Diazyme ADA assay on the Cobas® 6000 system for pleural fluid samples analysis. Imprecision, linearity, calibration curve stability, interference, and correlation studies were completed. The Diazyme ADA assay demonstrated excellent precision (CVADA assay correlated well with the Giusti method (r(2)=0.93) but exhibited a negative bias (~ -30%). The Diazyme ADA assay on the Cobas® 6000 system represents a rapid, accurate, precise and reliable method for determination of ADA activity in pleural fluid samples. Copyright © 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  14. Rethinking ADA signage standards for low-vision accessibility.

    Science.gov (United States)

    Arditi, Aries

    2017-05-01

    Americans With Disabilities Act (ADA) and International Code Council (ICC) standards for accessible buildings and facilities affect design and construction of all new and renovated buildings throughout the United States, and form the basis for compliance with the ADA. While these standards may result in acceptable accessibility for people who are fully blind, they fall far short of what they could and should accomplish for those with low vision. In this article I critique the standards, detailing their lack of evidence base and other shortcomings. I suggest that simply making existing requirements stricter (e.g., by mandating larger letter size or higher contrasts) will not ensure visual accessibility and therefore cannot act as a valid basis for compliance with the law. I propose two remedies. First, requirements for visual characteristics of signs intended to improve access for those with low vision should be expressed not in terms of physical features, such as character height and contrast, but rather in terms of the distance at which a sign can be read by someone with nominally normal (20/20) visual acuity under expected lighting conditions for the installed environment. This would give sign designers greater choice in design parameters but place on them the burden of ensuring legibility. Second, mounting of directional signs, which are critical for effective and efficient wayfinding, should be required to be in consistent and approachable locations so that those with reduced acuity may view them at close distance.

  15. Efficient Ada multitasking on a RISC register window architecture

    Science.gov (United States)

    Kearns, J. P.; Quammen, D.

    1987-01-01

    This work addresses the problem of reducing context switch overhead on a processor which supports a large register file - a register file much like that which is part of the Berkeley RISC processors and several other emerging architectures (which are not necessarily reduced instruction set machines in the purest sense). Such a reduction in overhead is particularly desirable in a real-time embedded application, in which task-to-task context switch overhead may result in failure to meet crucial deadlines. A storage management technique by which a context switch may be implemented as cheaply as a procedure call is presented. The essence of this technique is the avoidance of the save/restore of registers on the context switch. This is achieved through analysis of the static source text of an Ada tasking program. Information gained during that analysis directs the optimized storage management strategy for that program at run time. A formal verification of the technique in terms of an operational control model and an evaluation of the technique's performance via simulations driven by synthetic Ada program traces are presented.

  16. Beyond ADA Accessibility Requirements: Meeting Seniors' Needs for Toilet Transfers.

    Science.gov (United States)

    Lee, Su Jin; Sanford, Jon; Calkins, Margaret; Melgen, Sarah; Endicott, Sarah; Phillips, Anjanette

    2018-04-01

    To identify the optimal spatial and dimensional requirements of grab bars that support independent and assisted transfers by older adults and their care providers. Although research has demonstrated that toilet grab bars based on the Americans with Disabilities Act (ADA) Accessibility Standards do not meet the needs of older adults, the specific dimensional requirements for alternative configurations are unknown. A two-phased study with older adults and care providers in residential facilities was conducted to determine the optimal requirements for grab bars. Seniors and caregivers in skilled nursing facilities performed transfers using a mock-up toilet. In Phase 1, participants evaluated three grab bar configurations to identify optimal characteristics for safety, ease of use, comfort, and helpfulness. These characteristics were then validated for using ability-matched samples in Phase 2. The optimal configuration derived in Phase 1 included fold-down grab bars on both sides of the toilet (14" from centerline [CL] of toilet, 32" above the floor, and extended a minimum of 6" in front of the toilet) with one side open and a sidewall 24" from CL of toilet on the other. Phase 2 feedback was significantly positive for independent and one-person transfers and somewhat lower, albeit still positive, for two-person transfers. The study provides substantial evidence that bilateral grab bars are significantly more effective than those that comply with current ADA Accessibility Standards. Findings provide specific spatial and dimensional attributes for grab bar configurations that would be most effective in senior facilities.

  17. Modular crystals as modulated structures

    DEFF Research Database (Denmark)

    Elcoro, L.; Perez-Mato, J.M.; Friese, K.

    2008-01-01

    The use of the superspace formalism is extended to the description and refinement of the homologous series of modular structures with two symmetry-related modules with different orientations. The lillianite homologous series has been taken as a study case. Starting from a commensurate modulated...... composite description with two basic subsystems corresponding to the two different modules, it is shown how a more efficient description can be achieved using so-called zigzag modulation functions. These linear zigzag modulations, newly implemented in the program JANA2006, have very large fixed amplitudes...... and introduce in the starting model the two orientations of the underlying module sublattices. We show that a composite approach with this type of function, which treats the cations and anions as two separate subsystems forming a misfit compound, is the most appropriate and robust method for the refinements....

  18. Modular reactor head shielding system

    International Nuclear Information System (INIS)

    Jacobson, E. B.

    1985-01-01

    An improved modular reactor head shielding system is provided that includes a frame which is removably assembled on a reactor head such that no structural or mechanical alteration of the head is required. The shielding system also includes hanging assemblies to mount flexible shielding pads on trolleys which can be moved along the frame. The assemblies allow individual pivoting movement of the pads. The pivoting movement along with the movement allowed by the trolleys provides ease of access to any point on the reactor head. The assemblies also facilitate safe and efficient mounting of the pads directly to and from storage containers such that workers have additional shielding throughout virtually the entire installation and removal process. The flexible shielding pads are designed to interleave with one another when assembled around the reactor head for substantially improved containment of radiation leakage

  19. MODULAR MANIPULATOR FOR ROBOTICS APPLICATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Joseph W. Geisinger, Ph.D.

    2001-07-31

    ARM Automation, Inc. is developing a framework of modular actuators that can address the DOE's wide range of robotics needs. The objective of this effort is to demonstrate the effectiveness of this technology by constructing a manipulator from these actuators within a glovebox for Automated Plutonium Processing (APP). At the end of the project, the system of actuators was used to construct several different manipulator configurations, which accommodate common glovebox tasks such as repackaging. The modular nature and quickconnects of this system simplify installation into ''hot'' boxes and any potential modifications or repair therein. This work focused on the development of self-contained robotic actuator modules including the embedded electronic controls for the purpose of building a manipulator system. Both of the actuators developed under this project contain the control electronics, sensors, motor, gear train, wiring, system communications and mechanical interfaces of a complete robotics servo device. Test actuators and accompanying DISC{trademark}s underwent validation testing at The University of Texas at Austin and ARM Automation, Inc. following final design and fabrication. The system also included custom links, an umbilical cord, an open architecture PC-based system controller, and operational software that permitted integration into a completely functional robotic manipulator system. The open architecture on which this system is based avoids proprietary interfaces and communication protocols which only serve to limit the capabilities and flexibility of automation equipment. The system was integrated and tested in the contractor's facility for intended performance and operations. The manipulator was tested using the full-scale equipment and process mock-ups. The project produced a practical and operational system including a quantitative evaluation of its performance and cost.

  20. MODULAR MANIPULATOR FOR ROBOTICS APPLICATIONS

    International Nuclear Information System (INIS)

    Geisinger, Joseph W. Ph.D.

    2001-01-01

    ARM Automation, Inc. is developing a FR-amework of modular actuators that can address the DOE's wide range of robotics needs. The objective of this effort is to demonstrate the effectiveness of this technology by constructing a manipulator FR-om these actuators within a glovebox for Automated Plutonium Processing (APP). At the end of the project, the system of actuators was used to construct several different manipulator configurations, which accommodate common glovebox tasks such as repackaging. The modular nature and quickconnects of this system simplify installation into ''hot'' boxes and any potential modifications or repair therein. This work focused on the development of self-contained robotic actuator modules including the embedded electronic controls for the purpose of building a manipulator system. Both of the actuators developed under this project contain the control electronics, sensors, motor, gear train, wiring, system communications and mechanical interfaces of a complete robotics servo device. Test actuators and accompanying DISC(trademark)s underwent validation testing at The University of Texas at Austin and ARM Automation, Inc. following final design and fabrication. The system also included custom links, an umbilical cord, an open architecture PC-based system controller, and operational software that permitted integration into a completely functional robotic manipulator system. The open architecture on which this system is based avoids proprietary interfaces and communication protocols which only serve to limit the capabilities and flexibility of automation equipment. The system was integrated and tested in the contractor's facility for intended performance and operations. The manipulator was tested using the full-scale equipment and process mock-ups. The project produced a practical and operational system including a quantitative evaluation of its performance and cost

  1. Specialization can drive the evolution of modularity.

    Directory of Open Access Journals (Sweden)

    Carlos Espinosa-Soto

    2010-03-01

    Full Text Available Organismal development and many cell biological processes are organized in a modular fashion, where regulatory molecules form groups with many interactions within a group and few interactions between groups. Thus, the activity of elements within a module depends little on elements outside of it. Modularity facilitates the production of heritable variation and of evolutionary innovations. There is no consensus on how modularity might evolve, especially for modules in development. We show that modularity can increase in gene regulatory networks as a byproduct of specialization in gene activity. Such specialization occurs after gene regulatory networks are selected to produce new gene activity patterns that appear in a specific body structure or under a specific environmental condition. Modules that arise after specialization in gene activity comprise genes that show concerted changes in gene activities. This and other observations suggest that modularity evolves because it decreases interference between different groups of genes. Our work can explain the appearance and maintenance of modularity through a mechanism that is not contingent on environmental change. We also show how modularity can facilitate co-option, the utilization of existing gene activity to build new gene activity patterns, a frequent feature of evolutionary innovations.

  2. Size reduction of complex networks preserving modularity

    Energy Technology Data Exchange (ETDEWEB)

    Arenas, A.; Duch, J.; Fernandez, A.; Gomez, S.

    2008-12-24

    The ubiquity of modular structure in real-world complex networks is being the focus of attention in many trials to understand the interplay between network topology and functionality. The best approaches to the identification of modular structure are based on the optimization of a quality function known as modularity. However this optimization is a hard task provided that the computational complexity of the problem is in the NP-hard class. Here we propose an exact method for reducing the size of weighted (directed and undirected) complex networks while maintaining invariant its modularity. This size reduction allows the heuristic algorithms that optimize modularity for a better exploration of the modularity landscape. We compare the modularity obtained in several real complex-networks by using the Extremal Optimization algorithm, before and after the size reduction, showing the improvement obtained. We speculate that the proposed analytical size reduction could be extended to an exact coarse graining of the network in the scope of real-space renormalization.

  3. Do published ADA studies support the ADA-EASD position statement for the management of hyperglycaemia in type 2 diabetics?

    Science.gov (United States)

    Rimareix, Frédérique; Bauduceau, Bernard

    2013-07-01

    The American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) published a position statement in 2012 on the management of hyperglycaemia in patients with type 2 diabetes. The Société Francophone du Diabète (SFD) adopted it while awaiting future French recommendations. This new care approach individualises the therapeutic choices and objectives for each patient based on their characteristics, through emphasis on the need for mutual cooperation with the patient in decision-making. Glycaemic management should naturally be considered in the context of overall cardiovascular risk reduction, which should remain the primary objective of treatment. The cornerstone of this treatment is based on lifestyle modifications, with the addition of metformin monotherapy if the desired glycaemic control is not attained. There are multiple second- and third-line treatment possibilities, and insulin therapy is an option that can be considered early in the bitherapy stage. On the whole, large published studies at the ADA conference in Philadelphia in June 2012, which are the subject of this article, support this patient-centred position statement. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  4. Autoimmune dysregulation and purine metabolism in adenosine deaminase (ADA-deficiency

    Directory of Open Access Journals (Sweden)

    Aisha Vanessa Sauer

    2012-08-01

    Full Text Available Genetic defects in the adenosine deaminase (ADA gene are among the most common causes for severe combined immunodeficiency (SCID. ADA-SCID patients suffer from lymphopenia, severely impaired cellular and humoral immunity, failure to thrive and recurrent infections. Currently available therapeutic options for this otherwise fatal disorder include bone marrow transplantation (BMT, enzyme replacement therapy with bovine ADA (PEG-ADA or hematopoietic stem cell gene therapy (HSC-GT. Although varying degrees of immune reconstitution can be achieved by these treatments, breakdown of tolerance is a major concern in ADA-SCID. Immune dysregulation such as autoimmune hypothyroidism, diabetes mellitus, hemolytic anemia, and immune thrombocytopenia are frequently observed in milder forms of the disease. However, several reports document similar complications also in patients on long-term PEG-ADA and after BMT or GT treatment.A skewed repertoire and decreased immune functions have been implicated in autoimmunity observed in certain B-cell and/or T-cell immunodeficiencies, but it remains unclear to what extent specific mechanisms of tolerance are affected in ADA deficiency. Herein we provide an overview about ADA-SCID and the autoimmune manifestations reported in these patients before and after treatment. We also assess the value of the ADA-deficient mouse model as a useful tool to study both immune and metabolic disease mechanisms. With focus on regulatory T and B cells we discuss the lymphocyte subpopulations particularly prone to contribute to the loss of self-tolerance and onset of autoimmunity in ADA deficiency. Moreover we address which aspects of immune dysregulation are specifically related to alterations in purine metabolism caused by the lack of ADA and the subsequent accumulation of metabolites with immunomodulatory properties.

  5. Recognition of sign language gestures using neural networks

    Directory of Open Access Journals (Sweden)

    Simon Vamplew

    2007-04-01

    Full Text Available This paper describes the structure and performance of the SLARTI sign language recognition system developed at the University of Tasmania. SLARTI uses a modular architecture consisting of multiple feature-recognition neural networks and a nearest-neighbour classifier to recognise Australian sign language (Auslan hand gestures.

  6. Recognition of sign language gestures using neural networks

    OpenAIRE

    Simon Vamplew

    2007-01-01

    This paper describes the structure and performance of the SLARTI sign language recognition system developed at the University of Tasmania. SLARTI uses a modular architecture consisting of multiple feature-recognition neural networks and a nearest-neighbour classifier to recognise Australian sign language (Auslan) hand gestures.

  7. Generalized epidemic process on modular networks.

    Science.gov (United States)

    Chung, Kihong; Baek, Yongjoo; Kim, Daniel; Ha, Meesoon; Jeong, Hawoong

    2014-05-01

    Social reinforcement and modular structure are two salient features observed in the spreading of behavior through social contacts. In order to investigate the interplay between these two features, we study the generalized epidemic process on modular networks with equal-sized finite communities and adjustable modularity. Using the analytical approach originally applied to clique-based random networks, we show that the system exhibits a bond-percolation type continuous phase transition for weak social reinforcement, whereas a discontinuous phase transition occurs for sufficiently strong social reinforcement. Our findings are numerically verified using the finite-size scaling analysis and the crossings of the bimodality coefficient.

  8. Algebra and Arithmetic of Modular Forms

    DEFF Research Database (Denmark)

    Rustom, Nadim

    In [Rus14b] and [Rus14a], we study graded rings of modular forms over congruence subgroups, with coefficients in subrings A of C, and determine bounds of the weights of modular forms constituting a minimal set of generators, as well as on the degree of the generators of the ideal of relations...... between them. We give an algorithm that computes the structures of these rings, and formulate conjectures on the minimal generating weight for modular forms with coefficients in Z. We discuss questions of finiteness of systems of Hecke eigenvalues modulo pm, for a prime p and an integer m ≥ 2, in analogy...

  9. Modularity for Modulating Exercises and Levels

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop; Nielsen, Camilla Balslev

    2011-01-01

    The modular interactive tiles aim at engaging anybody (elderly, carer, hospital personnel, children) in performing playful and motivating physical activities. Inspired by modular robotics, each tile is a self-contained module with processing power and communication to neighbouring modules....... In this paper, we investigate the therapeutic use. We show how the tiles are tested extensively with cardiac patients, COLD patients and stroke patients in hospitals and in the private homes of patients and elderly. We find that therapists are using the modular aspect of the tiles for personalized training...

  10. A Modular Approach to Redundant Robot Control

    International Nuclear Information System (INIS)

    Anderson, R.J.

    1997-12-01

    This paper describes a modular approach for computing redundant robot kinematics. First some conventional redundant control methods are presented and shown to be 'passive control laws', i.e. they can be represented by a network consisting of passive elements. These networks are then put into modular form by applying scattering operator techniques. Additional subnetwork modules can then be added to further shape the motion. Modules for obstacle detection, joint limit avoidance, proximity sensing, and for imposing nonlinear velocity constraints are presented. The resulting redundant robot control system is modular, flexible and robust

  11. Carrier frequency of a nonsense mutation in the adenosine deaminase (ADA) gene implies a high incidence of ADA-deficient severe combined immunodeficiency (SCID) in Somalia and a single, common haplotype indicates common ancestry

    DEFF Research Database (Denmark)

    Sanchez Sanchez, Juan Jose; Monaghan, Gemma; Børsting, Claus

    2007-01-01

    Inherited adenosine deaminase (ADA) deficiency is a rare metabolic disorder that causes immunodeficiency, varying from severe combined immunodeficiency (SCID) in the majority of cases to a less severe form in a small minority of patients. Five patients of Somali origin from four unrelated families......, with severe ADA-SCID, were registered in the Greater London area. Patients and their parents were investigated for the nonsense mutation Q3X (ADA c7C>T), two missense mutations K80R (ADA c239A>G) and R142Q (ADA c425G>A), and a TAAA repeat located at the 3' end of an Alu element (AluVpA) positioned 1.1 kb...... upstream of the ADA transcription start site. All patients were homozygous for the haplotype ADA-7T/ADA-239G/ADA-425G/AluVpA7. Among 207 Somali immigrants to Denmark, the frequency of ADA c7C>T and the maximum likelihood estimate of the frequency of the haplotype ADA-7T/ADA-239G/ADA-425G/AluVpA7 were both...

  12. The Alzheimer's Disease Assessment Scale-Cognitive-Plus (ADAS-Cog-Plus): an expansion of the ADAS-Cog to improve responsiveness in MCI.

    Science.gov (United States)

    Skinner, Jeannine; Carvalho, Janessa O; Potter, Guy G; Thames, April; Zelinski, Elizabeth; Crane, Paul K; Gibbons, Laura E

    2012-12-01

    The Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-Cog) is widely used in AD, but may be less responsive to change when used in people with mild cognitive impairment (MCI). Participants from the Alzheimer's Disease Neuroimaging Initiative were administered a neuropsychological battery and 1.5 T MRI scans over 2-3 years. Informants were queried regarding functional impairments. Some participants had lumbar punctures to obtain cerebrospinal fluid (CSF). We added executive functioning (EF) and functional ability (FA) items to the ADAS-Cog to generate candidate augmented measures. We calibrated these candidates using baseline data (n = 811) and selected the best candidate that added EF items alone and that added EF and FA items. We selected candidates based on their responsiveness over three years in a training sample of participants with MCI (n = 160). We compared traditional ADAS-Cog scores with the two candidates based on their responsiveness in a validation sample of participants with MCI (n = 234), ability to predict conversion to dementia (n = 394), strength of association with baseline MRI (n = 394) and CSF biomarkers (n = 193). The selected EF candidate added category fluency (ADAS Plus EF), and the selected EF and FA candidate added category fluency, Digit Symbol, Trail Making, and five items from the Functional Assessment Questionnaire (ADAS Plus EF&FA). The ADAS Plus EF& FA performed as well as or better than traditional ADAS-Cog scores. Adding EF and FA items to the ADAS-Cog may improve responsiveness among people with MCI without impairing validity.

  13. Ada Compiler Validation Summary Report: Certificate Number: 901112W1. 11116 Cray Research, Inc., Cray Ada Compiler, Release 2.0, Cray X-MP/EA (Host & Target)

    Science.gov (United States)

    1990-11-12

    semaphores : 0.00 44858 Waiting on shared registers : 0.00 0 Waiting on A-registers/funct.units : 19.69 5551338711 Waiting on S-registers/funct.units...dependent bodies that implement the fundamental low-level primitives on which SR-3082 2.0 Cray Research, Inc. 73 Ada Program Runtime Model Cray Ada...operations provided by the runtime library are performed synchronously , with program execution suspended until the 1/O operation is complete. The

  14. Verified compilation of Concurrent Managed Languages

    Science.gov (United States)

    2017-11-01

    Communications Division Information Directorate This report is published in the interest of scientific and technical information exchange, and its...271, 2007. [85] Viktor Vafeiadis. Modular fine-grained concurrency verification. Technical Report UCAM-CL-TR- 726, University of Cambridge, Computer...VERIFIED COMPILATION OF CONCURRENT MANAGED LANGUAGES PURDUE UNIVERSITY NOVEMBER 2017 FINAL TECHNICAL REPORT APPROVED FOR PUBLIC RELEASE

  15. School Issues Under [Section] 504 and the ADA: The Latest and Greatest.

    Science.gov (United States)

    Aleman, Steven R.

    This paper highlights recent guidance and rulings from the Office of Civil Rights (OCR) of interest to administrators, advocates, and attorneys. It is a companion piece to Student Issues on SectionNB504/ADA: The Latest and Greatest. Compliance with SectionNB504 and the Americans with Disabilities Act (ADA) continues to involve debate and dialog on…

  16. CREASE 6.0 Catalog of Resources for Education in Ada and Software Engineering

    Science.gov (United States)

    1992-02-01

    Programming Software Engineering Strong Typing Tasking Audene . Computer Scientists Terbook(s): Barnes, J. Programming in Ada, 3rd ed. Addison-Wesley...Ada. Concept: Abstract Data Types Management Overview Package Real-Time Programming Tasking Audene Computer Scientists Textbook(s): Barnes, J

  17. Cartalk 2000: development of a co-operative ADAS based on vehicle-to-vehicle communication

    NARCIS (Netherlands)

    Morsink, P.L.J.; Hallouzi, R.; Dagli, I.; Cseh, C.; Schäfers, L.; Nelisse, M.W.; Bruin, D. de

    2003-01-01

    Advanced Driver Assistance Systems (ADAS) benefit from using vehicle-to-vehicle communication. In the 5th framework EC project CarTALK2000 co-operative ADAS are designed, tested and evaluated with respect to increasing traffic safety, efficiency and driving comfort. Communication based longitudinal

  18. Environment model creation and ADAS architecture for trucks : design and implementation of a sensor fusion algorithm

    NARCIS (Netherlands)

    Stamatopoulos, E.

    2016-01-01

    This report presents a structural approach for environment model creation and ADAS architecture for trucks. In particular, an appropriate sensor suite that is suitable for a set of ADAS functions is defined. On this basis, the development of a proof of concept for an Environment Model system, by

  19. ADA genetic polymorphism and the effect of smoking on neonatal bilirubinemia and developmental parameters.

    Science.gov (United States)

    Gloria-Bottini, F; Magrini, A; Cozzoli, E; Bergamaschi, A; Bottini, E

    2008-11-01

    Genetic variability of metabolic enzymes may influence the effect of cigarette smoking on intrauterine development and on early neonatal events. To investigate the role of adenosine deaminase genetic polymorphism on the effect of smoking on neonatal bilirubinemia and developmental parameters. Analysis of association between adenosine deaminase phenotypes and neonatal developmental parameters. Prospective study of serum bilirubin level in relation to adenosine deaminase phenotype. We have studied 360 consecutive newborn infants from the Caucasian population of Rome. Serum bilirubin concentration was determined at birth and every 24 h for the first five days. Overall maternal smoking is associated with a slight decrease in the incidence of phototherapy (13.4% in non smoking vs 11.7% in smoking mothers) and with a reduction of birth weight (3374 g in non smoking mothers vs 3133 g in smoking mothers). There is a significant interaction between smoke and adenosine deaminase. While in non smoking mothers the incidence of phototherapy in carriers of ADA 2 allele is higher than in ADA 1 phenotype, in infants from smoking mothers the pattern is reversed and the incidence of phototherapy in carriers of ADA 2 allele is lower than in infants with ADA 1 phenotype. Other neonatal bilirubin parameters follow a similar pattern of interaction between smoking and ADA. The negative effect of smoke on birth weight is much more evident in infant with ADA 1 phenotype than in those carrying the ADA 2 allele. The data suggest that ADA phenotype modifies the effect of smoking on developmental and bilirubin parameters.

  20. 76 FR 57013 - Recordkeeping and Reporting Requirements Under Title VII, the ADA, and GINA

    Science.gov (United States)

    2011-09-15

    ... EQUAL EMPLOYMENT OPPORTUNITY COMMISSION 29 CFR Part 1602 RIN 3046-AA89 Recordkeeping and Reporting Requirements Under Title VII, the ADA, and GINA AGENCY: Equal Employment Opportunity Commission. ACTION... under title VII, the ADA, and GINA. (76 FR 31892, June 2, 2011). No requests to present oral testimony...

  1. 76 FR 12753 - Notice of Temporary Closures on Public Lands in Ada and Elmore Counties, ID

    Science.gov (United States)

    2011-03-08

    ... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLIDB00200 LF20000ES.JS0000 LFESFTF60000] Notice of Temporary Closures on Public Lands in Ada and Elmore Counties, ID AGENCY: Bureau of Land... business hours. SUPPLEMENTARY INFORMATION: The Big Fire closure affects public lands located in Ada County...

  2. Large distributed control system using Ada in fusion research

    International Nuclear Information System (INIS)

    Van Arsdall, P J; Woodruff, J P.

    1998-01-01

    Construction of the National Ignition Facility laser at Lawrence Livermore National Laboratory features a distributed control system that uses object-oriented software engineering techniques. Control of 60,000 devices is effected using a network of some 500 computers. The software is being written in Ada and communicates through CORBA. Software controls are implemented in two layers: individual device controllers and a supervisory layer. The software architecture provides services in the form of frameworks that address issues common to event-driven control systems. Those services are allocated to levels that strictly prescribe their interdependency so the levels are separately reusable. The project has completed its final design review. The delivery of the first increment takes place in October 1998. Keywords Distributed control system, object-oriented development, CORBA, application frameworks, levels of abstraction

  3. Modular Actuators for Space Applications, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Rocketstar Robotics is proposing the development of a modern dual drive actuator. Rocketstar has put together numerous modern concepts for modular actuators that...

  4. Massive Modularity of Space and Surface Systems

    Data.gov (United States)

    National Aeronautics and Space Administration — This project will conduct a systems level investigation of a modular design and operations approach for future NASA exploration systems. Particular emphasis will be...

  5. Honeywell modular automation system computer software documentation

    International Nuclear Information System (INIS)

    Cunningham, L.T.

    1997-01-01

    This document provides a Computer Software Documentation for a new Honeywell Modular Automation System (MAS) being installed in the Plutonium Finishing Plant (PFP). This system will be used to control new thermal stabilization furnaces in HA-21I

  6. 48 CFR 39.103 - Modular contracting.

    Science.gov (United States)

    2010-10-01

    ... the Government is not required to procure additional increments. (e) To avoid obsolescence, a modular... maximum extent practicable, deliveries under the contract should be scheduled to occur within 18 months...

  7. Contrasting platform thinking and product modularization

    DEFF Research Database (Denmark)

    Boer, Henrike Engele Elisabeth; Persson, Magnus

    2015-01-01

    Product modularization and platform thinking are both practices that seek to alleviate the negative impact of product customization and variety on internal operations by relying on economies of substitution. Through the use of a standardized pool of components and interfaces, these practices aim...... to create a broad spectrum of product choices. At first sight, product modularization and platform thinking are very similar. The difference between these practices can, however, be found in the manner in which they employ standardization. Where product modularization focuses on creating standardized...... variants. There is a general lack of research addressing the contingency factors that dictate the appropriateness of the use of product modularization and platform thinking in different contexts. To our knowledge, no large-scale empirical research has been reported in which the two concepts, contextual...

  8. Automatic Modeling and Simulation of Modular Robots

    Science.gov (United States)

    Jiang, C.; Wei, H.; Zhang, Y.

    2018-03-01

    The ability of reconfiguration makes modular robots have the ability of adaptable, low-cost, self-healing and fault-tolerant. It can also be applied to a variety of mission situations. In this manuscript, a robot platform which relied on the module library was designed, based on the screw theory and module theory. Then, the configuration design method of the modular robot was proposed. And the different configurations of modular robot system have been built, including industrial mechanical arms, the mobile platform, six-legged robot and 3D exoskeleton manipulator. Finally, the simulation and verification of one system among them have been made, using the analyses of screw kinematics and polynomial planning. The results of experiments demonstrate the feasibility and superiority of this modular system.

  9. Modular thought in the circuit analysis

    Science.gov (United States)

    Wang, Feng

    2018-04-01

    Applied to solve the problem of modular thought, provides a whole for simplification's method, the complex problems have become of, and the study of circuit is similar to the above problems: the complex connection between components, make the whole circuit topic solution seems to be more complex, and actually components the connection between the have rules to follow, this article mainly tells the story of study on the application of the circuit modular thought. First of all, this paper introduces the definition of two-terminal network and the concept of two-terminal network equivalent conversion, then summarizes the common source resistance hybrid network modular approach, containing controlled source network modular processing method, lists the common module, typical examples analysis.

  10. Automatic Specialization of Modular Robot Limbs

    Data.gov (United States)

    National Aeronautics and Space Administration — Modular robotic systems have the potential to be adapted to varying tasks using a single platform and enable customizable robots to be developed faster and more...

  11. Small modular reactors are 'crucial technology'

    Science.gov (United States)

    Johnston, Hamish

    2018-03-01

    Small modular nuclear reactors (SMRs) offer a way for the UK to reduce carbon dioxide emissions from electricity generation, while allowing the country to meet the expected increase in demand for electricity from electric vehicles and other uses.

  12. Outsourcing Sealift for the Modular Force

    National Research Council Canada - National Science Library

    Donnie Walker, Jr, Flem B

    2008-01-01

    .... Army transforms its force to modular expeditionary brigade combat teams to compensate for these evolving challenges and threats, the importance of strategic sealift becomes paramount in terms of power projection...

  13. Understanding Complex Construction Systems Through Modularity

    DEFF Research Database (Denmark)

    Jensen, Tor Clarke; Bekdik, Baris; Thuesen, Christian

    2014-01-01

    This paper develops a framework for understanding complexity in construction projects by combining theories of complexity management and modularization. The framework incorporates three dimensions of product, process, and organizational modularity with the case of gypsum wall elements. The analysis...... system, rather than a modular, although the industry forces modular organizational structures. This creates a high complexity degree caused by the non-alignment of building parts and organizations and the frequent swapping of modules....... finds that the main driver of complexity is the fragmentation of the design and production, which causes the production modules to construct and install new product types and variants for each project as the designers are swapped for every project. The many interfaces are characteristics of an integral...

  14. Sound insulation design of modular construction housing

    OpenAIRE

    Yates, D. J.; Hughes, Lawrence; Campbell, A.

    2007-01-01

    This paper provides an insight into the acoustic issues of modular housing using the Verbus System of construction. The paper briefly summarises the history of the development of Verbus modular housing and the acoustic design considerations of the process. Results are presented from two sound insulation tests conducted during the course of the project. The results are discussed in terms of compliance with Approved Document E1 and increased performance standards such as EcoHomes2.

  15. Reliability and diagnostic of modular systems

    Directory of Open Access Journals (Sweden)

    J. Kohlas

    2014-01-01

    Full Text Available Reliability and diagnostic are in general two problems discussed separately. Yet the two problems are in fact closely related to each other. Here, this relation is considered in the simple case of modular systems. We show, how the computation of reliability and diagnostic can efficiently be done within the same Bayesian network induced by the modularity of the structure function of the system.

  16. Modular rate laws for enzymatic reactions: thermodynamics, elasticities and implementation.

    Science.gov (United States)

    Liebermeister, Wolfram; Uhlendorf, Jannis; Klipp, Edda

    2010-06-15

    Standard rate laws are a key requisite for systematically turning metabolic networks into kinetic models. They should provide simple, general and biochemically plausible formulae for reaction velocities and reaction elasticities. At the same time, they need to respect thermodynamic relations between the kinetic constants and the metabolic fluxes and concentrations. We present a family of reversible rate laws for reactions with arbitrary stoichiometries and various types of regulation, including mass-action, Michaelis-Menten and uni-uni reversible Hill kinetics as special cases. With a thermodynamically safe parameterization of these rate laws, parameter sets obtained by model fitting, sampling or optimization are guaranteed to lead to consistent chemical equilibrium states. A reformulation using saturation values yields simple formulae for rates and elasticities, which can be easily adjusted to the given stationary flux distributions. Furthermore, this formulation highlights the role of chemical potential differences as thermodynamic driving forces. We compare the modular rate laws to the thermodynamic-kinetic modelling formalism and discuss a simplified rate law in which the reaction rate directly depends on the reaction affinity. For automatic handling of modular rate laws, we propose a standard syntax and semantic annotations for the Systems Biology Markup Language. An online tool for inserting the rate laws into SBML models is freely available at www.semanticsbml.org. Supplementary data are available at Bioinformatics online.

  17. Language Revitalization.

    Science.gov (United States)

    Hinton, Leanne

    2003-01-01

    Surveys developments in language revitalization and language death. Focusing on indigenous languages, discusses the role and nature of appropriate linguistic documentation, possibilities for bilingual education, and methods of promoting oral fluency and intergenerational transmission in affected languages. (Author/VWL)

  18. Prescribing Pattern of Oral Antihyperglycaemic Drugs, Rationality and Adherence to American Diabetes Association (ADA) Treatment Guidelines among Type 2 Diabetes Mellitus (T2DM) Postmenopausal Women.

    Science.gov (United States)

    Sharma, Sudhaa; Tandon, Vishal R; Roshi; Mahajan, Annil

    2016-01-01

    Oral antihyperglycaemic prescription trends keep on changing and thus the drug prescription trend study may prove to be powerful exploratory tool for health care providers. To investigate trends in prescriptions of oral antihyperglycaemic drugs (OHDs) among postmenopausal women suffering from T2DM in India and evaluate the rationality and adherence to ADA treatment guidelines. An observational, cross-sectional descriptive prescription audit (n=500) was carried. Postmenopausal women were interviewed in their local language using pre-tested pre validated questionnaire after verbal informed consent at a teaching tertiary care hospital of north India. Oral antihyperglycaemic drugs (OHDs) drugs were categorized as per the pharmacological classification. Adherence to available clinical practice guidelines/recommendations issued under American Diabetes Association (ADA) 2015 Guidelines as well as rationality of these prescriptions were assessed using WHO Guide to Good Prescribing. Mean age of the study population was 58.14±12.86. Mean duration since menopause was 5.3 years and of T2DM was 9.5 years. A 93.4% of the prescriptions had only OHDs whereas 6.6% of the prescriptions had various insulin preprations + OHDs (pADA treatment guidelines was observed.

  19. The TOTEM modular trigger system

    Energy Technology Data Exchange (ETDEWEB)

    Bagliesi, M.G., E-mail: mg.bagliesi@pi.infn.i [University of Siena and INFN Pisa (Italy); Berretti, M.; Cecchi, R.; Greco, V.; Lami, S.; Latino, G.; Oliveri, E.; Pedreschi, E.; Scribano, A.; Spinella, F.; Turini, N. [University of Siena and INFN Pisa (Italy)

    2010-05-21

    The TOTEM experiment will measure the total cross-section with the luminosity independent method and study elastic and diffractive scattering at the LHC. We are developing a modular trigger system, based on programmable logic, that will select meaningful events within 2.5{mu}s. The trigger algorithm is based on a tree structure in order to obtain information compression. The trigger primitive is generated directly on the readout chip, VFAT, that has a specific fast output that gives low resolution hits information. In two of the TOTEM detectors, Roman Pots and T2, a coincidence chip will perform track recognition directly on the detector readout boards, while for T1 the hits are transferred from the VFATs to the trigger hardware. Starting from more than 2000 bits delivered by the detector electronics, we extract, in a first step, six trigger patterns of 32 LVDS signals each; we build, then, on a dedicated board, a 1-bit (L1) trigger signal for the TOTEM experiment and 16 trigger bits to the CMS experiment global trigger system for future common data taking.

  20. The TOTEM modular trigger system

    International Nuclear Information System (INIS)

    Bagliesi, M.G.; Berretti, M.; Cecchi, R.; Greco, V.; Lami, S.; Latino, G.; Oliveri, E.; Pedreschi, E.; Scribano, A.; Spinella, F.; Turini, N.

    2010-01-01

    The TOTEM experiment will measure the total cross-section with the luminosity independent method and study elastic and diffractive scattering at the LHC. We are developing a modular trigger system, based on programmable logic, that will select meaningful events within 2.5μs. The trigger algorithm is based on a tree structure in order to obtain information compression. The trigger primitive is generated directly on the readout chip, VFAT, that has a specific fast output that gives low resolution hits information. In two of the TOTEM detectors, Roman Pots and T2, a coincidence chip will perform track recognition directly on the detector readout boards, while for T1 the hits are transferred from the VFATs to the trigger hardware. Starting from more than 2000 bits delivered by the detector electronics, we extract, in a first step, six trigger patterns of 32 LVDS signals each; we build, then, on a dedicated board, a 1-bit (L1) trigger signal for the TOTEM experiment and 16 trigger bits to the CMS experiment global trigger system for future common data taking.

  1. Theory for the Emergence of Modularity in Complex Systems

    Science.gov (United States)

    Deem, Michael; Park, Jeong-Man

    2013-03-01

    Biological systems are modular, and this modularity evolves over time and in different environments. A number of observations have been made of increased modularity in biological systems under increased environmental pressure. We here develop a theory for the dynamics of modularity in these systems. We find a principle of least action for the evolved modularity at long times. In addition, we find a fluctuation dissipation relation for the rate of change of modularity at short times. We discuss a number of biological and social systems that can be understood with this framework. The modularity of the protein-protein interaction network increases when yeast are exposed to heat shock, and the modularity of the protein-protein networks in both yeast and E. coli appears to have increased over evolutionary time. Food webs in low-energy, stressful environments are more modular than those in plentiful environments, arid ecologies are more modular during droughts, and foraging of sea otters is more modular when food is limiting. The modularity of social networks changes over time: stock brokers instant messaging networks are more modular under stressful market conditions, criminal networks are more modular under increased police pressure, and world trade network modularity has decreased

  2. Subunits of ADA-two-A-containing (ATAC) or Spt-Ada-Gcn5-acetyltrasferase (SAGA) Coactivator Complexes Enhance the Acetyltransferase Activity of GCN5.

    Science.gov (United States)

    Riss, Anne; Scheer, Elisabeth; Joint, Mathilde; Trowitzsch, Simon; Berger, Imre; Tora, László

    2015-11-27

    Histone acetyl transferases (HATs) play a crucial role in eukaryotes by regulating chromatin architecture and locus specific transcription. GCN5 (KAT2A) is a member of the GNAT (Gcn5-related N-acetyltransferase) family of HATs. In metazoans this enzyme is found in two functionally distinct coactivator complexes, SAGA (Spt Ada Gcn5 acetyltransferase) and ATAC (Ada Two A-containing). These two multiprotein complexes comprise complex-specific and shared subunits, which are organized in functional modules. The HAT module of ATAC is composed of GCN5, ADA2a, ADA3, and SGF29, whereas in the SAGA HAT module ADA2b is present instead of ADA2a. To better understand how the activity of human (h) hGCN5 is regulated in the two related, but different, HAT complexes we carried out in vitro HAT assays. We compared the activity of hGCN5 alone with its activity when it was part of purified recombinant hATAC or hSAGA HAT modules or endogenous hATAC or hSAGA complexes using histone tail peptides and full-length histones as substrates. We demonstrated that the subunit environment of the HAT complexes into which GCN5 incorporates determines the enhancement of GCN5 activity. On histone peptides we show that all the tested GCN5-containing complexes acetylate mainly histone H3K14. Our results suggest a stronger influence of ADA2b as compared with ADA2a on the activity of GCN5. However, the lysine acetylation specificity of GCN5 on histone tails or full-length histones was not changed when incorporated in the HAT modules of ATAC or SAGA complexes. Our results thus demonstrate that the catalytic activity of GCN5 is stimulated by subunits of the ADA2a- or ADA2b-containing HAT modules and is further increased by incorporation of the distinct HAT modules in the ATAC or SAGA holo-complexes. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  3. Investigation of the ADA Language Implementation of the Hellenic Command Control and Information System.

    Science.gov (United States)

    1982-06-01

    libary packages which support machine dependent physical interfaces, interrupt structures or special devices. Thus, programs and libraries written in...obtains real-time data, makes and imple- ments decisions and receives and originates digital messages. The major equipment items which are appropriate...maintenance. g. Provide digital communications access processing. Each microcomputer can be programmed to perform a specific set of functions using prepared

  4. Issues to be Considered in the Evaluation of Technical Proposals from the Ada (Trademark) Language Perspective.

    Science.gov (United States)

    1985-06-10

    flowcharts - hierarchical charts - data flow diagrams - finite state diagrams - control flow diagrams - decision tables/trees - entity-relationship...and beginners ; for example, is prompting via menus provided for beginners and single keystroke capability provided for experienced users? 2-13 - input

  5. ADA Deficiency: Evaluation of the Clinical and Laboratory Features and the Outcome.

    Science.gov (United States)

    Cagdas, Deniz; Gur Cetinkaya, Pınar; Karaatmaca, Betül; Esenboga, Saliha; Tan, Cagman; Yılmaz, Togay; Gümüş, Ersin; Barış, Safa; Kuşkonmaz, Barış; Ozgur, Tuba Turul; Bali, Pawan; Santisteban, Ines; Orhan, Diclehan; Yüce, Aysel; Cetinkaya, Duygu; Boztug, Kaan; Hershfield, Michael; Sanal, Ozden; Tezcan, İlhan

    2018-05-09

    Adenosine deaminase (ADA) deficiency is an autosomal recessive primary immunodeficiency. It results in the intracellular accumulation of toxic metabolites which have effects particularly on lymphocytes and the brain. The aim of this study was to evaluate the outcome of 13 ADA-deficient patients. We planned to evaluate their clinical and laboratory findings before and after enzyme replacement therapy (ERT), allogeneic hematopoietic stem cell transplantation (aHSCT), and hematopoietic stem cell gene therapy (HSCGT). Measurement of ADA enzyme activity and metabolites and sequencing of the ADA gene were performed in most of the patients with ADA deficiency. One of the patients with late-onset ADA deficiency was diagnosed by the help of primary immunodeficiency panel screening. Ten out of 13 patients were diagnosed as SCID, while 3 out of 13 were diagnosed as delayed-/late-onset ADA deficiency. Late-onset ADA deficiency patients had clinical and laboratory findings of combined immunodeficiency (CID). Eight patients with ADA-SCID were found to have higher levels of ADA metabolite (dAXP%) (62.1% (34.6-71.9)) than 3 patients with delayed-/late-onset ADA deficiency (6.9% (2.1-8.9). All but one patient with SCID had T-B-NK- phenotype, one had T-B-NK+ phenotype. Genetic defect was documented in 11 patients. Four out of 11 patients had compound heterozygous defects. Three out of 4 patients with compound heterozygous defects had delayed-onset/late-onset ADA deficiency. Seven out of 11 patients with SCID had homozygous defects. Five out of 7 had the same homozygous indel frameshift mutation (c.955-959delGAAGA) showing a founder effect. There were two novel splice site defects: one (IVS10+2T>C) was heterozygous in a patient with late-onset ADA deficiency, and the other was homozygous (IVS2delT+2) in a SCID patient. Other defects were missense defects. Nine out of 13 patients were put on pegylated ADA ERT. Four out of six patients were transplanted without using a conditioning

  6. The ada operon of Mycobacterium tuberculosis encodes two DNA methyltransferases for inducible repair of DNA alkylation damage.

    Science.gov (United States)

    Yang, Mingyi; Aamodt, Randi M; Dalhus, Bjørn; Balasingham, Seetha; Helle, Ina; Andersen, Pernille; Tønjum, Tone; Alseth, Ingrun; Rognes, Torbjørn; Bjørås, Magnar

    2011-06-10

    The ada operon of Mycobacterium tuberculosis, which encodes a composite protein of AdaA and AlkA and a separate AdaB/Ogt protein, was characterized. M. tuberculosis treated with N-methyl-N'-nitro-N-nitrosoguanidine induced transcription of the adaA-alkA and adaB genes, suggesting that M. tuberculosis mount an inducible response to methylating agents. Survival assays of the methyltransferase defective Escherichia coli mutant KT233 (ada ogt), showed that expression of the adaB gene rescued the alkylation sensitivity. Further, adaB but not adaA-alkA complemented the hypermutator phenotype of KT233. Purified AdaA-AlkA and AdaB possessed methyltransferase activity. These data suggested that AdaB counteract the cytotoxic and mutagenic effect of O(6)-methylguanine, while AdaA-AlkA most likely transfers methyl groups from innocuous methylphosphotriesters. AdaA-AlkA did not possess alkylbase DNA glycosylase activity nor rescue the alkylation sensitivity of the E. coli mutant BK2118 (tag alkA). We propose that AdaA-AlkA is a positive regulator of the adaptive response in M. tuberculosis. It thus appears that the ada operon of M. tuberculosis suppresses the mutagenic effect of alkylation but not the cytotoxic effect of lesions such as 3-methylpurines. Collectively, these data indicate that M. tuberculosis hypermutator strains with defective adaptive response genes might sustain robustness to cytotoxic alkylation DNA damage and confer a selective advantage contributing to host adaptation. Copyright © 2011 Elsevier B.V. All rights reserved.

  7. Modular ORIGEN-S for multi-physics code systems

    International Nuclear Information System (INIS)

    Yesilyurt, Gokhan; Clarno, Kevin T.; Gauld, Ian C.; Galloway, Jack

    2011-01-01

    The ORIGEN-S code in the SCALE 6.0 nuclear analysis code suite is a well-validated tool to calculate the time-dependent concentrations of nuclides due to isotopic depletion, decay, and transmutation for many systems in a wide range of time scales. Application areas include nuclear reactor and spent fuel storage analyses, burnup credit evaluations, decay heat calculations, and environmental assessments. Although simple to use within the SCALE 6.0 code system, especially with the ORIGEN-ARP graphical user interface, it is generally complex to use as a component within an externally developed code suite because of its tight coupling within the infrastructure of the larger SCALE 6.0 system. The ORIGEN2 code, which has been widely integrated within other simulation suites, is no longer maintained by Oak Ridge National Laboratory (ORNL), has obsolete data, and has a relatively small validation database. Therefore, a modular version of the SCALE/ORIGEN-S code was developed to simplify its integration with other software packages to allow multi-physics nuclear code systems to easily incorporate the well-validated isotopic depletion, decay, and transmutation capability to perform realistic nuclear reactor and fuel simulations. SCALE/ORIGEN-S was extensively restructured to develop a modular version that allows direct access to the matrix solvers embedded in the code. Problem initialization and the solver were segregated to provide a simple application program interface and fewer input/output operations for the multi-physics nuclear code systems. Furthermore, new interfaces were implemented to access and modify the ORIGEN-S input variables and nuclear cross-section data through external drivers. Three example drivers were implemented, in the C, C++, and Fortran 90 programming languages, to demonstrate the modular use of the new capability. This modular version of SCALE/ORIGEN-S has been embedded within several multi-physics software development projects at ORNL, including

  8. Modular ORIGEN-S for multi-physics code systems

    Energy Technology Data Exchange (ETDEWEB)

    Yesilyurt, Gokhan; Clarno, Kevin T.; Gauld, Ian C., E-mail: yesilyurtg@ornl.gov, E-mail: clarnokt@ornl.gov, E-mail: gauldi@ornl.gov [Oak Ridge National Laboratory, TN (United States); Galloway, Jack, E-mail: jack@galloways.net [Los Alamos National Laboratory, Los Alamos, NM (United States)

    2011-07-01

    The ORIGEN-S code in the SCALE 6.0 nuclear analysis code suite is a well-validated tool to calculate the time-dependent concentrations of nuclides due to isotopic depletion, decay, and transmutation for many systems in a wide range of time scales. Application areas include nuclear reactor and spent fuel storage analyses, burnup credit evaluations, decay heat calculations, and environmental assessments. Although simple to use within the SCALE 6.0 code system, especially with the ORIGEN-ARP graphical user interface, it is generally complex to use as a component within an externally developed code suite because of its tight coupling within the infrastructure of the larger SCALE 6.0 system. The ORIGEN2 code, which has been widely integrated within other simulation suites, is no longer maintained by Oak Ridge National Laboratory (ORNL), has obsolete data, and has a relatively small validation database. Therefore, a modular version of the SCALE/ORIGEN-S code was developed to simplify its integration with other software packages to allow multi-physics nuclear code systems to easily incorporate the well-validated isotopic depletion, decay, and transmutation capability to perform realistic nuclear reactor and fuel simulations. SCALE/ORIGEN-S was extensively restructured to develop a modular version that allows direct access to the matrix solvers embedded in the code. Problem initialization and the solver were segregated to provide a simple application program interface and fewer input/output operations for the multi-physics nuclear code systems. Furthermore, new interfaces were implemented to access and modify the ORIGEN-S input variables and nuclear cross-section data through external drivers. Three example drivers were implemented, in the C, C++, and Fortran 90 programming languages, to demonstrate the modular use of the new capability. This modular version of SCALE/ORIGEN-S has been embedded within several multi-physics software development projects at ORNL, including

  9. 76 FR 66034 - Proposed Foreign-Trade Zone-Ada and Canyon Counties, ID, Under Alternative Site Framework...

    Science.gov (United States)

    2011-10-25

    ... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [Docket 65-2011] Proposed Foreign-Trade Zone--Ada... establish a general-purpose foreign-trade zone at sites in Ada and Canyon Counties, Idaho, adjacent to the... proposed service area under the ASF would be Ada and Canyon Counties, Idaho. If approved, the applicant...

  10. 77 FR 46008 - Approval and Promulgation of State Implementation Plans: Idaho; Boise-Northern Ada County Air...

    Science.gov (United States)

    2012-08-02

    ... Promulgation of State Implementation Plans: Idaho; Boise-Northern Ada County Air Quality Maintenance Area... the Northern Ada County Air Quality Maintenance Area Second 10-year Carbon Monoxide Maintenance Plan...-Northern Ada County Air Quality Maintenance Area will maintain air quality standards for carbon monoxide...

  11. 76 FR 14745 - Notice To Rescind a Notice of Intent To Prepare an Environmental Impact Statement, Ada and Canyon...

    Science.gov (United States)

    2011-03-17

    ... To Prepare an Environmental Impact Statement, Ada and Canyon Counties, ID AGENCY: Federal Highway... prepare an Environmental Impact Statement for a proposed highway project in Ada and Canyon County, Idaho... Highway 44 from Exit 25 at Interstate 84 in Canyon County to Ballantyne Lane in Ada County. The project is...

  12. 77 FR 45962 - Approval and Promulgation of State Implementation Plans: Idaho; Boise-Northern Ada County Air...

    Science.gov (United States)

    2012-08-02

    ... Promulgation of State Implementation Plans: Idaho; Boise-Northern Ada County Air Quality Maintenance Area... (IDEQ) submitted the Northern Ada County Air Quality Maintenance Area Second 10-year Carbon Monoxide... Ada County Air Quality Maintenance Area will maintain air quality standards for carbon monoxide (CO...

  13. Modular Rake of Pitot Probes

    Science.gov (United States)

    Dunlap, Timothy A.; Henry, Michael W.; Homyk, Raymond P.

    2004-01-01

    The figure presents selected views of a modular rake of 17 pitot probes for measuring both transient and steady-state pressures in a supersonic wind tunnel. In addition to pitot tubes visible in the figure, the probe modules contain (1) high-frequency dynamic-pressure transducers connected through wires to remote monitoring circuitry and (2) flow passages that lead to tubes that, in turn, lead to remote steady-state pressure transducers. Prior pitot-probe rakes were fabricated as unitary structures, into which the individual pitot probes were brazed. Repair or replacement of individual probes was difficult, costly, and time-consuming because (1) it was necessary to remove entire rakes in order to unbraze individual malfunctioning probes and (2) the heat of unbrazing a failed probe and of brazing a new probe in place could damage adjacent probes. In contrast, the modules in the present probe are designed to be relatively quickly and easily replaceable with no heating and, in many cases, without need for removal of the entire rake from the wind tunnel. To remove a malfunctioning probe, one first removes a screw-mounted V-cross-section cover that holds the probe and adjacent probes in place. Then one removes a screw-mounted cover plate to gain access to the steady-state pressure tubes and dynamicpressure wires. Next, one disconnects the tube and wires of the affected probe. Finally, one installs a new probe in the reverse of the aforementioned sequence. The wire connections can be made by soldering, but to facilitate removal and installation, they can be made via miniature plugs and sockets. The connections between the probe flow passages and the tubes leading to the remote pressure sensors can be made by use of any of a variety of readily available flexible tubes that can be easily pulled off and slid back on for removal and installation, respectively.

  14. Modular architectures for quantum networks

    Science.gov (United States)

    Pirker, A.; Wallnöfer, J.; Dür, W.

    2018-05-01

    We consider the problem of generating multipartite entangled states in a quantum network upon request. We follow a top-down approach, where the required entanglement is initially present in the network in form of network states shared between network devices, and then manipulated in such a way that the desired target state is generated. This minimizes generation times, and allows for network structures that are in principle independent of physical links. We present a modular and flexible architecture, where a multi-layer network consists of devices of varying complexity, including quantum network routers, switches and clients, that share certain resource states. We concentrate on the generation of graph states among clients, which are resources for numerous distributed quantum tasks. We assume minimal functionality for clients, i.e. they do not participate in the complex and distributed generation process of the target state. We present architectures based on shared multipartite entangled Greenberger–Horne–Zeilinger states of different size, and fully connected decorated graph states, respectively. We compare the features of these architectures to an approach that is based on bipartite entanglement, and identify advantages of the multipartite approach in terms of memory requirements and complexity of state manipulation. The architectures can handle parallel requests, and are designed in such a way that the network state can be dynamically extended if new clients or devices join the network. For generation or dynamical extension of the network states, we propose a quantum network configuration protocol, where entanglement purification is used to establish high fidelity states. The latter also allows one to show that the entanglement generated among clients is private, i.e. the network is secure.

  15. Nanosyntax: A short primer to a new approach to language

    Directory of Open Access Journals (Sweden)

    Michal Starke

    2010-01-01

    Full Text Available Nanosyntax is a new approach to the architecture of language, designed to make (better sense of the new empirical picture emerging from recent years of syntactic research. It is a large-scale project, addressing a wide array of issues, ranging from big issues such as the modularity of language, to fine details, such as the derivation of allomorphy in irregular patterns of given languages and its interaction with syntactic structures.

  16. Hierarchical modularity in human brain functional networks

    Directory of Open Access Journals (Sweden)

    David Meunier

    2009-10-01

    Full Text Available The idea that complex systems have a hierarchical modular organization originates in the early 1960s and has recently attracted fresh support from quantitative studies of large scale, real-life networks. Here we investigate the hierarchical modular (or “modules-within-modules” decomposition of human brain functional networks, measured using functional magnetic resonance imaging (fMRI in 18 healthy volunteers under no-task or resting conditions. We used a customized template to extract networks with more than 1800 regional nodes, and we applied a fast algorithm to identify nested modular structure at several hierarchical levels. We used mutual information, 0 < I < 1, to estimate the similarity of community structure of networks in different subjects, and to identify the individual network that is most representative of the group. Results show that human brain functional networks have a hierarchical modular organization with a fair degree of similarity between subjects, I=0.63. The largest 5 modules at the highest level of the hierarchy were medial occipital, lateral occipital, central, parieto-frontal and fronto-temporal systems; occipital modules demonstrated less sub-modular organization than modules comprising regions of multimodal association cortex. Connector nodes and hubs, with a key role in inter-modular connectivity, were also concentrated in association cortical areas. We conclude that methods are available for hierarchical modular decomposition of large numbers of high resolution brain functional networks using computationally expedient algorithms. This could enable future investigations of Simon's original hypothesis that hierarchy or near-decomposability of physical symbol systems is a critical design feature for their fast adaptivity to changing environmental conditions.

  17. Modular supervisory controller for hybrid power systems

    Energy Technology Data Exchange (ETDEWEB)

    Lemos Pereira, A. de

    2000-06-01

    The power supply of remote places has been commonly provided by thermal power plants, usually diesel generators. Although hybrid power systems may constitute the most economical solution in many applications their widespread application to the electrification schemes of remote areas still depends on improvements in the issues of design and operation control. The main limitations of the present hybrid power systems technology, which are identified in this work, are related to the control and supervision of the power system. Therefore this thesis focuses on the modularity of supervisory controllers in order to design cost-competitive and reliable hybrid power systems. The modular supervisory controller created in this project is considered an important part of a system design approach that aims to overcome the technical difficulties of the current engineering practice and contribute to open the market of hybrid power systems. The term modular refers to a set of design characteristics that allows the use of basically the same supervisory controller in different projects. The modularization and standardisation of the controller include several issues such as interfacing components, communication protocols, modelling, programming and control strategies. The modularity can reduce the highly specialised system engineering related to the integration of components, operation and control. It can also avoid the high costs for installation, service and maintenance. A modular algorithm for supervisory controllers has been developed (a Matlab program called SuperCon) using an object-oriented design and it has been tested through several simulations using different hybrid system configurations and different control strategies. This thesis presents a complete control system design process which can be used as the basis for the development and implementation of intelligent and autonomous supervisory controllers for hybrid power systems with modular characteristics. (au)

  18. Endomorphisms on half-sided modular inclusions

    International Nuclear Information System (INIS)

    Svegstrup, Rolf Dyre

    2006-01-01

    In algebraic quantum field theory we consider nets of von Neumann algebras indexed over regions of the space time. Wiesbrock [''Conformal quantum field theory and half-sided modular inclusions of von Neumann algebras,'' Commun. Math. Phys. 158, 537-543 (1993)] has shown that strongly additive nets of von Neumann algebras on the circle are in correspondence with standard half-sided modular inclusions. We show that a finite index endomorphism on a half-sided modular inclusion extends to a finite index endomorphism on the corresponding net of von Neumann algebras on the circle. Moreover, we present another approach to encoding endomorphisms on nets of von Neumann algebras on the circle into half-sided modular inclusions. There is a natural way to associate a weight to a Moebius covariant endomorphism. The properties of this weight have been studied by Bertozzini et al. [''Covariant sectors with infinite dimension and positivity of the energy,'' Commun. Math. Phys. 193, 471-492 (1998)]. In this paper we show the converse, namely, how to associate a Moebius covariant endomorphism to a given weight under certain assumptions, thus obtaining a correspondence between a class of weights on a half-sided modular inclusion and a subclass of the Moebius covariant endomorphisms on the associated net of von Neumann algebras. This allows us to treat Moebius covariant endomorphisms in terms of weights on half-sided modular inclusions. As our aim is to provide a framework for treating endomorphisms on nets of von Neumann algebras in terms of the apparently simpler objects of weights on half-sided modular inclusions, we lastly give some basic results for manipulations with such weights

  19. rCBF and cognitive impairment changes assessed by SPECT and ADAS-cog in late-onset Alzheimer's disease after 18 months of treatment with the cholinesterase inhibitors donepezil or galantamine.

    Science.gov (United States)

    Shirayama, Yukihiko; Takahashi, Michio; Oda, Yasunori; Yoshino, Kouhei; Sato, Koichi; Okubo, Toshiyuki; Iyo, Masaomi

    2017-12-15

    Late-onset Alzheimer's disease (AD) differs substantially from early-onset AD. In this cross sectional study we investigated brain perfusion changes after 18 months of treatment with cholinesterase inhibitors (ChEIs) donepezil or galantamine. Twenty-five drug-naïve late-onset AD patients were recruited from outpatient clinics. We examined brain perfusion using single photon emission computed tomography (SPECT) and used three-dimensional stereotactic surface projection (3D-SSP) and the stereotactic extraction estimation method (SEE) level 3 to analyze classified gyrus level segments. We assessed cognitive function using the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) grouped into three subgroup domains, language, memory, and praxis. In the follow-up data, some regions were further hypoperfused, reflecting worsening of the disease, while other regions showed alleviated hypoperfusion, potentially related to the ChEIs treatment. Regional cerebral blood flow (rCBF) decreased in the parietal cortex and increased in the frontal and the limbic cortices. Increased hypoperfusion significantly correlated with ADAS-cog scores changes were seen in the superior parietal lobule, inferior parietal lobule, angular gyrus, and supramarginal gyrus of the parietal cortex. Alleviated hypoperfusion significantly related to recovery of ADAS-cog scores were seen in the rectal and paracentral lobule of the frontal cortex, and the anterior cingulate of the limbic cortex. These regions showed significant relationships with total ADAS-cog and language, memory and praxis subscales scores. The current longitudinal study indicates prominent rCBF changes and their relationships with changes in ADAS-cog scores in late-onset AD patients.

  20. Development of Immunocapture-LC/MS Assay for Simultaneous ADA Isotyping and Semiquantitation

    Science.gov (United States)

    2016-01-01

    Therapeutic proteins and peptides have potential to elicit immune responses resulting in anti-drug antibodies that can pose problems for both patient safety and product efficacy. During drug development immunogenicity is usually examined by risk-based approach along with specific strategies for developing “fit-for-purpose” bioanalytical approaches. Enzyme-linked immunosorbent assays and electrochemiluminescence immunoassays are the most widely used platform for ADA detection due to their high sensitivity and throughput. During the past decade, LC/MS has emerged as a promising technology for quantitation of biotherapeutics and protein biomarkers in biological matrices, mainly owing to its high specificity, selectivity, multiplexing, and wide dynamic range. In fully taking these advantages, we describe here an immunocapture-LC/MS methodology for simultaneous isotyping and semiquantitation of ADA in human plasma. Briefly, ADA and/or drug-ADA complex is captured by biotinylated drug or anti-drug Ab, immobilized on streptavidin magnetic beads, and separated from human plasma by a magnet. ADA is then released from the beads and subjected to trypsin digestion followed by LC/MS detection of specific universal peptides for each ADA isotype. The LC/MS data are analyzed using cut-point and calibration curve. The proof-of-concept of this methodology is demonstrated by detecting preexisting ADA in human plasma. PMID:27034966

  1. Diagnostic Value of Serum Adenosine Deaminase (ADA) Level for Pulmonary Tuberculosis.

    Science.gov (United States)

    Salmanzadeh, Shokrollah; Tavakkol, Heshmatollah; Bavieh, Khalid; Alavi, Seyed Mohammad

    2015-03-01

    Diagnosis of tuberculosis (TB) is not always easy, thus employing methods with a short duration and acceptable sensitivity and specificity is necessary to diagnose TB. The aim of this study was to investigate the diagnostic value of serum adenosine deaminase (ADA) level for diagnosis of pulmonary tuberculosis. A total of 160 sex and age-matched subjects were included in this study, and were divided to four groups; forty patients with pulmonary tuberculosis (PTB) diagnosed based on the national TB program (NTP), forty patients with non-tuberculosis bacterial pneumonia, forty patients with lung cancer and forty people who were healthy in every respect. Serum adenosine deaminase activity in patients of each group was measured by the Giusti and Galanti calorimetry method using a commercial kit (Diazyme, USA). The ANOVA analysis was used to compare groups for quantitative variables. Mean serum ADA level in the PTB group was clearly higher than the mean serum ADA in the other three groups. Mean serum ADA was 26 IU/L in PTB patients, 19.48 IU/L in patients with pneumonia, 15.8 IU/L in patients with lung cancer, and 10.7 IU/L in the control group (P ADA in patients with PTB sensitivity and specificity was defined as 35% and 91%, respectively. Serum ADA activity with high specificity percentage may be a useful alternative test in restricted resource areas to rule out diagnosis of PTB. However, serum ADA activity is not a useful tool for TB diagnosis.

  2. Regulation of adenosine deaminase (ADA) on induced mouse experimental autoimmune uveitis (EAU) ‡

    Science.gov (United States)

    Liang, Dongchun; Zuo, Aijun; Zhao, Ronglan; Shao, Hui; Kaplan, Henry J.; Sun, Deming

    2016-01-01

    Adenosine is an important regulator of the immune response and adenosine deaminase (ADA) inhibits this regulatory effect by converting adenosine into functionally inactive molecules. Studies have shown that adenosine receptor (AR) agonists can be either anti- or pro-inflammatory. Clarification of the mechanisms that cause these opposing effects should provide a better guide for therapeutic intervention. In this study, we investigated the effect of ADA on the development of experimental autoimmune uveitis (EAU) induced by immunizing EAU-prone mice with a known uveitogenic peptide, IRBP1–20. Our results showed that the effective time to administer a single dose of ADA to suppress induction of EAU was 8–14 days post-immunization, shortly before EAU expression, but ADA treatment at other time points exacerbated disease. ADA preferentially inhibited Th17 responses and this effect was γδ T cell-dependent. Our results demonstrated that the existing immune status strongly influences the anti- or proinflammatory effects of ADA. Our observations should help improve the design of ADA- and AR-targeted therapies. PMID:26856700

  3. Development of Immunocapture-LC/MS Assay for Simultaneous ADA Isotyping and Semiquantitation.

    Science.gov (United States)

    Chen, Lin-Zhi; Roos, David; Philip, Elsy

    2016-01-01

    Therapeutic proteins and peptides have potential to elicit immune responses resulting in anti-drug antibodies that can pose problems for both patient safety and product efficacy. During drug development immunogenicity is usually examined by risk-based approach along with specific strategies for developing "fit-for-purpose" bioanalytical approaches. Enzyme-linked immunosorbent assays and electrochemiluminescence immunoassays are the most widely used platform for ADA detection due to their high sensitivity and throughput. During the past decade, LC/MS has emerged as a promising technology for quantitation of biotherapeutics and protein biomarkers in biological matrices, mainly owing to its high specificity, selectivity, multiplexing, and wide dynamic range. In fully taking these advantages, we describe here an immunocapture-LC/MS methodology for simultaneous isotyping and semiquantitation of ADA in human plasma. Briefly, ADA and/or drug-ADA complex is captured by biotinylated drug or anti-drug Ab, immobilized on streptavidin magnetic beads, and separated from human plasma by a magnet. ADA is then released from the beads and subjected to trypsin digestion followed by LC/MS detection of specific universal peptides for each ADA isotype. The LC/MS data are analyzed using cut-point and calibration curve. The proof-of-concept of this methodology is demonstrated by detecting preexisting ADA in human plasma.

  4. Measuring Modularity in Open Source Code Bases

    Directory of Open Access Journals (Sweden)

    Roberto Milev

    2009-03-01

    Full Text Available Modularity of an open source software code base has been associated with growth of the software development community, the incentives for voluntary code contribution, and a reduction in the number of users who take code without contributing back to the community. As a theoretical construct, modularity links OSS to other domains of research, including organization theory, the economics of industry structure, and new product development. However, measuring the modularity of an OSS design has proven difficult, especially for large and complex systems. In this article, we describe some preliminary results of recent research at Carleton University that examines the evolving modularity of large-scale software systems. We describe a measurement method and a new modularity metric for comparing code bases of different size, introduce an open source toolkit that implements this method and metric, and provide an analysis of the evolution of the Apache Tomcat application server as an illustrative example of the insights gained from this approach. Although these results are preliminary, they open the door to further cross-discipline research that quantitatively links the concerns of business managers, entrepreneurs, policy-makers, and open source software developers.

  5. Modular low-voltage electron emitters

    International Nuclear Information System (INIS)

    Berejka, Anthony J.

    2005-01-01

    Modular, low-voltage electron emitters simplify electron beam (EB) technology for many industrial uses and for research and development. Modular electron emitters are produced in quantity as sealed systems that are evacuated at the factory, eliminating the need for vacuum pumps at the point of use. A plug-out-plug-in method of replacement facilitates servicing. By using an ultra-thin 6-7 μm titanium foil window, solid-state power supplies, an innovative design to extract and spread the beam (enabling systems to be placed adjacent to each other to extend beam width) and touch-screen computer controls, these modular units combine ease of use and electrical transfer efficiency at voltages that can be varied between 80 kV and 150 kV with beam currents up to 40 mA per 25 cm across the beam window. These new devices have been made in three widths: 5 cm, 25 cm, and 40 cm. Details of the beam construction and illustrations of industrial uses will be presented. Traditional uses in the graphic arts and coatings areas have welcomed this modular technology as well as uses for surface sterilization. Being compact and lightweight (∼15 kg/emitter), these modular beams have been configured around complex shapes to achieve three-dimensional surface curing at high production rates

  6. Modular low-voltage electron emitters

    Science.gov (United States)

    Berejka, Anthony J.

    2005-12-01

    Modular, low-voltage electron emitters simplify electron beam (EB) technology for many industrial uses and for research and development. Modular electron emitters are produced in quantity as sealed systems that are evacuated at the factory, eliminating the need for vacuum pumps at the point of use. A plug-out-plug-in method of replacement facilitates servicing. By using an ultra-thin 6-7 μm titanium foil window, solid-state power supplies, an innovative design to extract and spread the beam (enabling systems to be placed adjacent to each other to extend beam width) and touch-screen computer controls, these modular units combine ease of use and electrical transfer efficiency at voltages that can be varied between 80 kV and 150 kV with beam currents up to 40 mA per 25 cm across the beam window. These new devices have been made in three widths: 5 cm, 25 cm, and 40 cm. Details of the beam construction and illustrations of industrial uses will be presented. Traditional uses in the graphic arts and coatings areas have welcomed this modular technology as well as uses for surface sterilization. Being compact and lightweight (∼15 kg/emitter), these modular beams have been configured around complex shapes to achieve three-dimensional surface curing at high production rates.

  7. Advantages of going modular in HTRs

    International Nuclear Information System (INIS)

    Reutler, H.; Lohnert, G.H.

    1984-01-01

    A multitude of problems that are encountered in large HTR power plans, constructively as well as concerning plant safety, can be related to the mere physical size of a large reactor core. In limiting the thermal power of an HTR-module to approximately 200 MW an inherent limitation of the fuel element temperature below critical values can be guaranteed for all possible core heat up accidents. Consequently, a significant failure rate of coated particles can be excluded and, hence, out of physical reasons, no intolerable fission product release from the core will ever have to be considered. The HTR-module is so qualified and very well suited for all possible plant sides which have to be taken into consideration for medium sized plants for the production of process steam and electricity. The cost investigations show considerable cost advantages for modular HTRs. For German conditions it was found that even a four-modular plant (800 MW/thermal) is competitive with a fossile-fueled plant of the same size, the specific plant costs were evaluated to be DM 4700/kW (electric). Moreover the investigations show that the increase of the power of the modular unit yields only small cost advantages, therefore in a modularized power plant it even would be possible to reduce the power of a modular unit below 200 MW without having to cope with severe economic penalties, if the distance from technological or safety limits is felt to be too small. (orig.)

  8. Modular co-evolution of metabolic networks

    Directory of Open Access Journals (Sweden)

    Yu Zhong-Hao

    2007-08-01

    Full Text Available Abstract Background The architecture of biological networks has been reported to exhibit high level of modularity, and to some extent, topological modules of networks overlap with known functional modules. However, how the modular topology of the molecular network affects the evolution of its member proteins remains unclear. Results In this work, the functional and evolutionary modularity of Homo sapiens (H. sapiens metabolic network were investigated from a topological point of view. Network decomposition shows that the metabolic network is organized in a highly modular core-periphery way, in which the core modules are tightly linked together and perform basic metabolism functions, whereas the periphery modules only interact with few modules and accomplish relatively independent and specialized functions. Moreover, over half of the modules exhibit co-evolutionary feature and belong to specific evolutionary ages. Peripheral modules tend to evolve more cohesively and faster than core modules do. Conclusion The correlation between functional, evolutionary and topological modularity suggests that the evolutionary history and functional requirements of metabolic systems have been imprinted in the architecture of metabolic networks. Such systems level analysis could demonstrate how the evolution of genes may be placed in a genome-scale network context, giving a novel perspective on molecular evolution.

  9. CITY GROUND DESIGN AND THE IMAGE OF THE CITY: THE PORTUGUESE CALÇADA

    Directory of Open Access Journals (Sweden)

    Antoni Remesar

    2014-10-01

    The pavement-form - including the "calçada-form"-is at the root of some of the flagship operations creating the image of the city (Havana, 1928; Alicante, 1957; the Ramblas in Barcelona, 1969; reform of the Avenida Atlantica in Rio by Burle Marx, 1970. However, these same operations show that the "form-calçada" does not meet many of the requirements of economy, security or universal accessibility required by the contemporary city. In the paper was to analyze the causes and reasons that hover over the announced death of calçada á Portugueza.

  10. Domain-Specific Modelling Languages in Bigraphs

    DEFF Research Database (Denmark)

    Perrone, Gian David

    " of models, in order to improve the utility of the models we build, and to ease the process of model construction by moving the languages we use to express such models closer to their respective domains. This thesis is concerned with the study of bigraphical reactive systems as a host for domain...... for deciding reaction rule causation. Finally, we provide a mechanism for the modular construction of domain-specic modelling languages as bigraphical reactive systems, exploring the relationship between vertical renement and language specialisation in this setting. The thesis is composed of several...

  11. AdaBoost-based algorithm for network intrusion detection.

    Science.gov (United States)

    Hu, Weiming; Hu, Wei; Maybank, Steve

    2008-04-01

    Network intrusion detection aims at distinguishing the attacks on the Internet from normal use of the Internet. It is an indispensable part of the information security system. Due to the variety of network behaviors and the rapid development of attack fashions, it is necessary to develop fast machine-learning-based intrusion detection algorithms with high detection rates and low false-alarm rates. In this correspondence, we propose an intrusion detection algorithm based on the AdaBoost algorithm. In the algorithm, decision stumps are used as weak classifiers. The decision rules are provided for both categorical and continuous features. By combining the weak classifiers for continuous features and the weak classifiers for categorical features into a strong classifier, the relations between these two different types of features are handled naturally, without any forced conversions between continuous and categorical features. Adaptable initial weights and a simple strategy for avoiding overfitting are adopted to improve the performance of the algorithm. Experimental results show that our algorithm has low computational complexity and error rates, as compared with algorithms of higher computational complexity, as tested on the benchmark sample data.

  12. Trends in languages for embedded systems

    International Nuclear Information System (INIS)

    Boasson, M.

    1986-01-01

    Characteristics of embedded systems are discussed. In particular, the role of the computer in such systems is highlighted. Special emphasis is placed on the different requirements different kinds of systems may place on program execution. From such requirements necessary programming constructs are derived and in an overview of currently used languages it is shown how evolution led to modern languages like Ada and CHILL. With the advent of cheap, fast and small processing units, exploitation of parallelism for enhancing system performance is becoming increasingly tempting. However, few languages support the design of such multi-processor systems. Some methods for dealing with this problem are discussed. Finally, systems architectures and associated languages for the use of techniques originally developed for AI research are adumbrated. (Auth.)

  13. Capital costs of modular HTR reactors

    International Nuclear Information System (INIS)

    Kugeler, K.; Froehling, W.

    1993-01-01

    A decisive factor in the introduction of a reactor line, in addition of its safety, which should exclude releases of radioactivity into the environment, is its economic development and, consequently, its competitiveness. The costs of the pressurized water reactor are used for comparison with the modular HTR reactor. If the measures proposed for evolutionary increases in safety of the PWR are taken, cost increases will have to be expected for that line. The modular HTR can now attain specific construction costs of 3000 deutschmarks per electric kilowatt. Mass production and the introduction of cost-reducing innovations can improve the economy of this line even further. In this way, the modular HTR concept offers the possibility to vendors and operators to set up new economic yardsticks in safety technology. (orig.) [de

  14. Harmonic Maass forms and mock modular forms

    CERN Document Server

    Bringmann, Kathrin; Ono, Ken

    2017-01-01

    Modular forms and Jacobi forms play a central role in many areas of mathematics. Over the last 10-15 years, this theory has been extended to certain non-holomorphic functions, the so-called "harmonic Maass forms". The first glimpses of this theory appeared in Ramanujan's enigmatic last letter to G. H. Hardy written from his deathbed. Ramanujan discovered functions he called "mock theta functions" which over eighty years later were recognized as pieces of harmonic Maass forms. This book contains the essential features of the theory of harmonic Maass forms and mock modular forms, together with a wide variety of applications to algebraic number theory, combinatorics, elliptic curves, mathematical physics, quantum modular forms, and representation theory.

  15. Robustness and modular structure in networks

    DEFF Research Database (Denmark)

    Bagrow, James P.; Lehmann, Sune; Ahn, Yong-Yeol

    2015-01-01

    -12]. Many complex systems, from power grids and the Internet to the brain and society [13-15], can be modeled using modular networks comprised of small, densely connected groups of nodes [16, 17]. These modules often overlap, with network elements belonging to multiple modules [18, 19]. Yet existing work...... on robustness has not considered the role of overlapping, modular structure. Here we study the robustness of these systems to the failure of elements. We show analytically and empirically that it is possible for the modules themselves to become uncoupled or non-overlapping well before the network disintegrates....... If overlapping modular organization plays a role in overall functionality, networks may be far more vulnerable than predicted by conventional percolation theory....

  16. PLM system support for modular product development

    DEFF Research Database (Denmark)

    Bruun, Hans Peter Lomholt; Mortensen, Niels Henrik; Harlou, Ulf

    2015-01-01

    A modular design strategy both enables, but also demands, parallelism in design activities and collaboration between a diversity of disciplines in companies, which often involves supporting computer-based tools for enhancing interaction, design management, and communication. Product data management...... (PDM) and product lifecycle management (PLM) systems offer support by automating and managing some of the operational complexity of modular design activities. PLM system tools are used for handling a variety of product definitions, to manage workflow of development activities, and to measure relational...... properties such as cost and performance. Companies often use a PLM tool for management of CAD files, documents, and drawings, but they do not take advantage of the full potential of the PLM system to support the development activities of modular product designs. The key result of this paper...

  17. Modular categories and 3-manifold invariants

    International Nuclear Information System (INIS)

    Tureav, V.G.

    1992-01-01

    The aim of this paper is to give a concise introduction to the theory of knot invariants and 3-manifold invariants which generalize the Jones polynomial and which may be considered as a mathematical version of the Witten invariants. Such a theory was introduced by N. Reshetikhin and the author on the ground of the theory of quantum groups. here we use more general algebraic objects, specifically, ribbon and modular categories. Such categories in particular arise as the categories of representations of quantum groups. The notion of modular category, interesting in itself, is closely related to the notion of modular tensor category in the sense of G. Moore and N. Seiberg. For simplicity we restrict ourselves in this paper to the case of closed 3-manifolds

  18. Balancing Modularity and Solution Space Freedom

    DEFF Research Database (Denmark)

    Vos, Maren A.; Raassens, Néomie; Van der Borgh, Michel

    2018-01-01

    that modularity reflects knowledge specialisation and solution space freedom reflects knowledge variety. Both of these dimensions affect organisational learning and, in turn, sustainable innovation. Second, we argue that the relationship between customisation and organisational learning is affected by supplier...... theory to provide insights into how TI firms can achieve ‘win-win’ situations where sustainable innovation is increased through customisation. First, we argue that customisation should be viewed two-dimensionally and identify both modularity and solution space freedom as important dimensions. We argue...... characteristics, specifically supplier sophistication. Survey data from 166 managers were used to empirically test the conceptual model and hypotheses. Polynomial response surface analysis confirms that customising by balancing high degrees of both modularity and solution space freedom results in superior...

  19. Modularization Technology in Power Plant Construction

    International Nuclear Information System (INIS)

    Kenji Akagi; Kouichi Murayama; Miki Yoshida; Junichi Kawahata

    2002-01-01

    Since the early 1980's, Hitachi has been developing and applying modularization technology to domestic nuclear power plant construction, and has achieved great rationalization. Modularization is one of the plant construction techniques which enables us to reduce site labor by pre-assembling components like equipment, pipes, valves and platforms in congested areas and installing them using large capacity cranes for cost reduction, better quality, safety improvement and shortening of construction time. In this paper, Hitachi's modularization technologies are described especially from with respect to their sophisticated design capabilities. The application of 3D-CAD at the detailed layout design stage, concurrent design environment achieved by the computer network, module design quantity control and the management system are described. (authors)

  20. Ada Dual-Use Summary: Ada Dual-Use Workshop Held in Vienna, Virginia on October 19-20, 1993. Ada Dual-Use Committee Briefing, November 8, 1993

    Science.gov (United States)

    1993-11-29

    Systems Agency C- 19 Novemtiber 8., 1993 Promoting the Use of Ada in Computer Science Curricula Timothy J. Long Ohio State University ®I To L4 ease...framework, distributed file systems, a high-performance fiber-optic connection and multi-processor modules to work with the OSF’s Mach 3 microkernel (again

  1. The 16-Year Evolution of Proximal Modular Stem Design – Eliminating Failure of Modular Junction

    Directory of Open Access Journals (Sweden)

    Thomas Tkach

    2017-10-01

    Full Text Available Background: The complexity of hip reconstruction has been and continues to be a perplexing problem with restoring leg length, femoral offset, joint stability and overall hip implant fixation. These were contributing factors that lead to the development of a novel proximal femoral component design “Apex Modular Stem” (Omni, Raynham, MA. The basic stem geometry features a straight stem with a metaphyseal fit and fill cone, a medial triangle and a modular neck junction that allows for version and offset adjustment. In recent years, there has been great concern with the use of modularity in total hip arthroplasty. The goals of this study are (1 to identify complications with the use of a proximal modular design and (2 demonstrated factors that have eliminated those complications. Methods: This is a retrospective study of a single surgeon series (Design A and Design B of using the same cementless stem and proximal modular neck body (Apex Modular Stem and Omni Mod Hip Stem from 2000 to 2016 totaling 2,125 stems. 483 stems were the Design A and 1,642 stems, were of the Design B style. Results: Design A, 483 stems were implanted between 2000 and 2004. 31 alignment pins sheared resulting in a revision rate of 6.4%. Design B, 1,642 stems have been implanted between 2004 and 2016 all by the same surgeon, with no failures of the modular junction. Conclusion: All implant devices entail a multitude of risks and benefits. The Apex Modular Stem (Design A, provided excellent fixation, minimal risk of modular junction  corrosion, and simple control of anteversion and femoral offset. The limitation was found to be the risk of the alignment pin shearing (6.4%. The pin was enlarged to make it 225% stronger in torsional resistance, and in a subsequent series of over 1,600 femoral stems in a single surgeon series, there were no pin failures over a 12 year duration.

  2. Geometric modular action and transformation groups

    International Nuclear Information System (INIS)

    Summers, S.J.

    1996-01-01

    We study a weak form of geometric modular action, which is naturally associated with transformation groups of partially ordered sets and which provides these groups with projective representations. Under suitable conditions it is shown that these groups are implemented by point transformations of topological spaces serving as models for space-times, leading to groups which may be interpreted as symmetry groups of the space-times. As concrete examples, it is shown that the Poincare group and the de Sitter group can be derived from this condition of geometric modular action. Further consequences and examples are discussed. (orig.)

  3. Model engineering in a modular PSA

    International Nuclear Information System (INIS)

    Friedlhuber, Thomas

    2014-01-01

    For the purpose of PSA (Probabilistic Safety Analysis) for complex industrial systems, often PSA models in the form of fault and event trees are developed to model the risk of unwanted situations (hazards). While the recent decades, PSA models have gained high acceptance and have been developed massively. This lead to an increase in model sizes and complexity. Today, PSA models are often difficult to understand and maintain. This manuscript presents the concept of a modular PSA. A modular PSA tries to cope with the increased complexity by the techniques of modularization and instantiation. Modularization targets to treat a model by smaller pieces (the 'modules') to regain control over models. Instantiation aims to configure a generic model to different contexts. Both try to reduce model complexity. A modular PSA proposes new functionality to manage PSA models. Current model management is rather limited and not efficient. This manuscript shows new methods to manage the evolutions (versions) and deviations (variants) of PSA models in a modular PSA. The concepts of version and variant management are presented in this thesis. In this context, a model comparison and fusion of PSA models is precised. Model comparison provides important feedback to model engineers and model fusion kind of combines the work from different model engineers (concurrent model engineering). Apart from model management, methods to understand the content of PSA models are presented. The methods focus to highlight the dependencies between modules rather than their contents. Dependencies are automatically derived from a model structure. They express relations between model objects (for example a fault tree may have dependencies to basic events). To visualize those dependencies (for example in form of a model cartography) can constitute a crucial aid to model engineers for understanding complex interrelations in PSA models. Within the scope of this thesis, a software named 'Andromeda' has been

  4. Proving relations between modular graph functions

    International Nuclear Information System (INIS)

    Basu, Anirban

    2016-01-01

    We consider modular graph functions that arise in the low energy expansion of the four graviton amplitude in type II string theory. The vertices of these graphs are the positions of insertions of vertex operators on the toroidal worldsheet, while the links are the scalar Green functions connecting the vertices. Graphs with four and five links satisfy several non-trivial relations, which have been proved recently. We prove these relations by using elementary properties of Green functions and the details of the graphs. We also prove a relation between modular graph functions with six links. (paper)

  5. Modular arrangement of regulatory RNA elements.

    Science.gov (United States)

    Roßmanith, Johanna; Narberhaus, Franz

    2017-03-04

    Due to their simple architecture and control mechanism, regulatory RNA modules are attractive building blocks in synthetic biology. This is especially true for riboswitches, which are natural ligand-binding regulators of gene expression. The discovery of various tandem riboswitches inspired the design of combined RNA modules with activities not yet found in nature. Riboswitches were placed in tandem or in combination with a ribozyme or temperature-responsive RNA thermometer resulting in new functionalities. Here, we compare natural examples of tandem riboswitches with recently designed artificial RNA regulators suggesting substantial modularity of regulatory RNA elements. Challenges associated with modular RNA design are discussed.

  6. Modular radwaste volume reduction and solidification systems

    International Nuclear Information System (INIS)

    Miller, E.L.

    1986-01-01

    This paper describes both the modular transportable and the modular mobile liquid radwaste volume reduction and solidification units based on a General Electric Company developed and patented process called AZTECH (a trademark of GE). An AZTECH system removes all water by azeotropic distillation and encapsulates the remaining solids in a polyester compound. The resulting monolith is suitable for either long term above ground storage or shallow land burial. Pilot and demonstration plant testing has confirmed the design parameters. The three processing modules are covered together with data which resulted in Nuclear Regulatory Commission approval on Dec. 30, 1985

  7. The ADAS-Cog revisited: novel composite scales based on ADAS-Cog to improve efficiency in MCI and early AD trials.

    Science.gov (United States)

    Raghavan, Nandini; Samtani, Mahesh N; Farnum, Michael; Yang, Eric; Novak, Gerald; Grundman, Michael; Narayan, Vaibhav; DiBernardo, Allitia

    2013-02-01

    The Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) has been used widely as a cognitive end point in Alzheimer's Disease (AD) clinical trials. Efforts to treat AD pathology at earlier stages have also used ADAS-Cog, but failure in these trials can be difficult to interpret because the scale has well-known ceiling effects that limit its use in mild cognitive impairment (MCI) and early AD. A wealth of data exists in ADAS-Cog from both historical trials and contemporary longitudinal natural history studies that can provide insights about parts of the scale that may be better suited for MCI and early AD trials. Using Alzheimer's Disease Neuroimaging Initiative study data, we identified the most informative cognitive measures from the ADAS-Cog and other available scales. We used cross-sectional analyses to characterize trajectories of ADAS-Cog and its individual subscales, as well as other cognitive, functional, or global measures across disease stages. Informative measures were identified based on standardized mean of 2-year change from baseline and were combined into novel composite endpoints. We assessed performance of the novel endpoints based on sample size requirements for a 2-year clinical trial. A bootstrap validation procedure was also undertaken to assess the reproducibility of the standardized mean changes of the selected measures and the corresponding composites. All proposed novel endpoints have improved standardized mean changes and thus improved statistical power compared with the ADAS-Cog 11. Further improvements were achieved by using cognitive-functional composites. Combining the novel composites with an enrichment strategy based on cerebral spinal fluid beta-amyloid (Aβ(1-42)) in a 2-year trial yielded gains in power of 20% to 40% over ADAS-Cog 11, regardless of the novel measure considered. An empirical, data-driven approach with existing instruments was used to derive novel composite scales based on ADAS-Cog 11 with improved performance

  8. Alteration of lysine 178 in the hinge region of the Escherichia coli ada protein interferes with activation of ada, but not alkA, transcription.

    OpenAIRE

    Saget, B M; Shevell, D E; Walker, G C

    1995-01-01

    The ada gene of Escherichia coli K-12 encodes the 39-kDa Ada protein, which consists of two domains joined by a hinge region that is sensitive to proteolytic cleavage in vitro. The amino-terminal domain has a DNA methyltransferase activity that repairs the S-diastereoisomer of methylphosphotriesters while the carboxyl-terminal domain has a DNA methyltransferase activity that repairs O6-methylguanine and O4-methylthymine lesions. Transfer of a methyl group to Cys-69 by repair of a methylphosph...

  9. Fine-Tuning ADAS Algorithm Parameters for Optimizing Traffic Safety and Mobility in Connected Vehicle Environment

    Science.gov (United States)

    With the development of Connected Vehicle Technology that facilitates wireless communication among vehicles and road-side infrastructure, the Advanced Driver Assistance Systems (ADAS) can be adopted as an effective tool for accelerating traffic safety and mobility optimization at...

  10. 78 FR 67303 - Americans With Disabilities Act (ADA) Accessibility Guidelines for Buildings and Facilities...

    Science.gov (United States)

    2013-11-12

    ... ARCHITECTURAL AND TRANSPORTATION BARRIERS COMPLIANCE BOARD 36 CFR Part 1191 RIN 3014-AA22 Americans With Disabilities Act (ADA) Accessibility Guidelines for Buildings and Facilities; Architectural Barriers Act (ABA) Accessibility Guidelines; Correction AGENCY: Architectural and Transportation Barriers...

  11. CSF ADA Determination in Early Diagnosis of Tuberculous Meningitis in HIV-Infected Patients.

    Science.gov (United States)

    Ghosh, Gopal Chandra; Sharma, Brijesh; Gupta, B B

    2016-01-01

    Tuberculous and Cryptococcal meningitis are common in HIV patients. A highly specific and sensitive rapid test for diagnosis of Tuberculous meningitis especially in setting of HIV is not available in developing countries where the burden of disease is high. We measured ADA (adenosine deaminase) levels using spectrophotometric method in the CSF of HIV patients with meningitis to differentiate Tuberculous meningitis from meningitis due to other causes. Kruskal-Wallis test was used to compare ADA values between tuberculous meningitis (TBM) and nontuberculous (non-TB) meningitis patients and a receiver-operating characteristic (ROC) analysis curve was drawn from these values. Levels of ADA in the CSF of patients with TBM were significantly higher than those in patients with meningitis due to other causes. CSF ADA level determination with a cut-off value of 6 IU/L was found to be highly specific and fairly sensitive test for the diagnosis of TBM in HIV positive patients.

  12. Region 10: Idaho Northern Ada County Adequate Letter (6/21/2013)

    Science.gov (United States)

    EPA approves motor vehicle emissions budget in the Northern Ada County PM10 State Implementation Plan, Maintenance Plan: Ten-Year Update for PM10 national ambient air quality standard, adequate for transportation conformity purposes.

  13. The implications of the ADA Amendments Act of 2008 for residency training program administration.

    Science.gov (United States)

    Regenbogen, Alexandra; Recupero, Patricia R

    2012-01-01

    The Americans with Disabilities Act (ADA) is rarely invoked by medical residents in training. Dr. Martin Jakubowski, a family medicine resident with Asperger's disorder, was dismissed for communicating poorly with patients, peers, and supervisors and for issuing dangerous medical orders. In an attempt to become reinstated, he sued under the ADA (Jakubowski v. The Christ Hospital), arguing that the program had failed to make reasonable accommodation for his disability. The Sixth Circuit Court of Appeals ruled in favor of the hospital, finding that although the doctor was disabled under the ADA, he had failed to demonstrate that he was otherwise qualified for the position. This article comments on the ADA Amendments Act of 2008, the Equal Employment Opportunity Commission (EEOC) guidelines from 2011 and their application to medical residency training, and the Accreditation Council for Graduate Medical Education (ACGME) core competencies as essential job functions.

  14. [Diagnostic value and functional correlations of the ADAS-Cog scale in Alzheimer's disease: data on NORMACODEM project].

    Science.gov (United States)

    Monllau, A; Pena-Casanova, J; Blesa, R; Aguilar, M; Bohm, P; Sol, J M; Hernandez, G

    2007-10-01

    The aims of this study were to assess the criterion validity of Alzheimer's Disease Assessment Scale (ADAS) and its cognitive subscale (ADAS-Cog) for the diagnosis of Alzheimer's disease (AD), and to determine their different cut-off scores and sensitivity and specificity values. In addition, we also attempted to study the possible correlations between cognitive scores (ADAS) and functional measures. 451 subjects were studied (254 controls, 86 subjects with mild cognitive impairment and 111 patients with AD). ADAS total score was obtained by adding the cognitive (ADAS-Cog) and non-cognitive (ADAS-Nocog) scales. Scores were adjusted for age and formal education. For assessing the possible correlation between cognitive and functional measures, the following instruments were administered: Rapid Disability Rating Scale-2 (RDRS-2), Blessed Dementia Rating Scale (BDRS) and the Interview for the Deterioration of Daily Living in Dementia (IDDD). ROC curves and Pearson correlation coefficient. ADAS best cut-off score for dementia was > or = 17 providing sensitivity and specificity values of 90.09% and 85.88 % respectively, while for the ADAS-Cog best cut-off score was > or = 12 with sensitivity and specificity values of 89.19 % and 88.53 % respectively. In both cases scores were adjusted for age and formal education. The area under the ROC curve was 0.95 and 0.94 respectively. Highly significant correlations were found for ADAS and 19 ADAS-Cog with the functional scales studied. Both, ADAS and ADAS-Cog report good validity in terms of sensitivity, specificity and as predictive value for AD. Moreover, significant correlations were found between the functional impairment observed in patients with AD and the overall scores achieved in the ADAS and ADAS-Cog.

  15. Retroviral vectors encoding ADA regulatory locus control region provide enhanced T-cell-specific transgene expression.

    Science.gov (United States)

    Trinh, Alice T; Ball, Bret G; Weber, Erin; Gallaher, Timothy K; Gluzman-Poltorak, Zoya; Anderson, French; Basile, Lena A

    2009-12-30

    Murine retroviral vectors have been used in several hundred gene therapy clinical trials, but have fallen out of favor for a number of reasons. One issue is that gene expression from viral or internal promoters is highly variable and essentially unregulated. Moreover, with retroviral vectors, gene expression is usually silenced over time. Mammalian genes, in contrast, are characterized by highly regulated, precise levels of expression in both a temporal and a cell-specific manner. To ascertain if recapitulation of endogenous adenosine deaminase (ADA) expression can be achieved in a vector construct we created a new series of Moloney murine leukemia virus (MuLV) based retroviral vector that carry human regulatory elements including combinations of the ADA promoter, the ADA locus control region (LCR), ADA introns and human polyadenylation sequences in a self-inactivating vector backbone. A MuLV-based retroviral vector with a self-inactivating (SIN) backbone, the phosphoglycerate kinase promoter (PGK) and the enhanced green fluorescent protein (eGFP), as a reporter gene, was generated. Subsequent vectors were constructed from this basic vector by deletion or addition of certain elements. The added elements that were assessed are the human ADA promoter, human ADA locus control region (LCR), introns 7, 8, and 11 from the human ADA gene, and human growth hormone polyadenylation signal. Retroviral vector particles were produced by transient three-plasmid transfection of 293T cells. Retroviral vectors encoding eGFP were titered by transducing 293A cells, and then the proportion of GFP-positive cells was determined using fluorescence-activated cell sorting (FACS). Non T-cell and T-cell lines were transduced at a multiplicity of infection (MOI) of 0.1 and the yield of eGFP transgene expression was evaluated by FACS analysis using mean fluorescent intensity (MFI) detection. Vectors that contained the ADA LCR were preferentially expressed in T-cell lines. Further improvements

  16. Retroviral vectors encoding ADA regulatory locus control region provide enhanced T-cell-specific transgene expression

    Science.gov (United States)

    2009-01-01

    Background Murine retroviral vectors have been used in several hundred gene therapy clinical trials, but have fallen out of favor for a number of reasons. One issue is that gene expression from viral or internal promoters is highly variable and essentially unregulated. Moreover, with retroviral vectors, gene expression is usually silenced over time. Mammalian genes, in contrast, are characterized by highly regulated, precise levels of expression in both a temporal and a cell-specific manner. To ascertain if recapitulation of endogenous adenosine deaminase (ADA) expression can be achieved in a vector construct we created a new series of Moloney murine leukemia virus (MuLV) based retroviral vector that carry human regulatory elements including combinations of the ADA promoter, the ADA locus control region (LCR), ADA introns and human polyadenylation sequences in a self-inactivating vector backbone. Methods A MuLV-based retroviral vector with a self-inactivating (SIN) backbone, the phosphoglycerate kinase promoter (PGK) and the enhanced green fluorescent protein (eGFP), as a reporter gene, was generated. Subsequent vectors were constructed from this basic vector by deletion or addition of certain elements. The added elements that were assessed are the human ADA promoter, human ADA locus control region (LCR), introns 7, 8, and 11 from the human ADA gene, and human growth hormone polyadenylation signal. Retroviral vector particles were produced by transient three-plasmid transfection of 293T cells. Retroviral vectors encoding eGFP were titered by transducing 293A cells, and then the proportion of GFP-positive cells was determined using fluorescence-activated cell sorting (FACS). Non T-cell and T-cell lines were transduced at a multiplicity of infection (MOI) of 0.1 and the yield of eGFP transgene expression was evaluated by FACS analysis using mean fluorescent intensity (MFI) detection. Results Vectors that contained the ADA LCR were preferentially expressed in T

  17. Modular nuclear fuel element, modular capsule for a such element and fabrication process for a modular capsule

    International Nuclear Information System (INIS)

    Chotard, A.

    1988-01-01

    The nuclear fuel rod is made by a tubular casing closed at both ends and containing a series of modular capsules with little play with the casing and made by a jacket closed by porous plugs at both ends and containing a stack of fuel pellets [fr

  18. A study of the portability of an Ada system in the software engineering laboratory (SEL)

    Science.gov (United States)

    Jun, Linda O.; Valett, Susan Ray

    1990-01-01

    A particular porting effort is discussed, and various statistics on analyzing the portability of Ada and the total staff months (overall and by phase) required to accomplish the rehost, are given. This effort is compared to past experiments on the rehosting of FORTRAN systems. The discussion includes an analysis of the types of errors encountered during the rehosting, the changes required to rehost the system, experiences with the Alsys IBM Ada compiler, the impediments encountered, and the lessons learned during this study.

  19. Regulation of adenosine deaminase (ADA) on induced mouse experimental autoimmune uveitis (EAU) ?

    OpenAIRE

    Liang, Dongchun; Zuo, Aijun; Zhao, Ronglan; Shao, Hui; Kaplan, Henry J.; Sun, Deming

    2016-01-01

    Adenosine is an important regulator of the immune response and adenosine deaminase (ADA) inhibits this regulatory effect by converting adenosine into functionally inactive molecules. Studies have shown that adenosine receptor (AR) agonists can be either anti- or pro-inflammatory. Clarification of the mechanisms that cause these opposing effects should provide a better guide for therapeutic intervention. In this study, we investigated the effect of ADA on the development of experimental autoim...

  20. Errors in ADAS-cog administration and scoring may undermine clinical trials results.

    Science.gov (United States)

    Schafer, K; De Santi, S; Schneider, L S

    2011-06-01

    The Alzheimer's Disease Assessment Scale - cognitive subscale (ADAS-cog) is the most widely used cognitive outcome measure in AD trials. Although errors in administration and scoring have been suggested as factors masking accurate estimates and potential effects of treatments, there have been few formal examinations of errors with the ADAS-cog. We provided ADAS-cog administration training using standard methods to raters who were designated as experienced, potential raters by sponsors or contract research organizations for two clinical trials. Training included 1 hour sessions on test administration, scoring, question periods, and required that raters individually view and score a model ADAS-cog administration. Raters scores were compared to the criterion scores established for the model administration. A total of 108 errors were made by 80.6% of the 72 raters; 37.5% made 1 error, 25.0% made 2 errors and 18.0% made 3 or more. Errors were made in all ADAS-cog subsections. The most common were in word finding difficulty (67% of the raters), word recognition (22%), and orientation (22%). For the raters who made 1, 2, or ≥ 3 errors the ADAS-cog score was 17.5 (95% CI, 17.3 - 17.8), 17.8 (17.0 - 18.5), and 18.8 (17.6 - 20.0), respectively, and compared to the criterion score, 18.3. ADAS-cog means differed significantly and the variances were more than twice as large between those who made errors on word finding and those who did not, 17.6 (SD=1.4) vs. 18.8 (SD=0.9), respectively (χ(2) = 37.2, P ADAS-cog scores and clinical trials outcomes. These errors may undermine detection of medication effects by contributing both to a biased point estimate and increased variance of the outcome.

  1. What is the clinically relevant change on the ADAS-Cog?

    Science.gov (United States)

    Schrag, Anette; Schott, Jonathan M

    2012-02-01

    To establish the minimal clinically relevant change (MCRC) on the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) for patients with mild Alzheimer's disease (AD). Cohort study. 59 recruiting sites for the Alzheimer's Disease Neuroimaging Initiative. Outpatients with AD in the Alzheimer's Disease Neuroimaging Initiative. The authors applied anchor-based MCRC methodology comparing ADAS-Cog change against clinicians' judgement of clinically relevant worsening between baseline and 6 months in four domains: memory and non-memory cognitive performance; Clinical Dementia Rating Scale; and Functional Assessment Questionnaire. The analysis was repeated for the 6-12-month interval. To support these findings, the authors calculated distribution-based measures including half-baseline SD (1/2 SD) and SEM. 181 patients (baseline ADAS-Cog score 18.5±6.4) had ADAS-Cog data at 0 and 6 months. Those undergoing clinically significant worsening on any of the four anchor questions (n=41-47) had an average ADAS-Cog change of 3.1-3.8 points. Similar results were found for the 177 patients with 6-12-month data. The average 1/2 SD for the baseline ADAS-Cog score was 3.2, and the SEM was 3.7. 3 points decline on the ADAS-Cog may be an appropriate MCRC for clinical trials of patients with early AD. However, further studies assessing the MCRC for improvement on the ADAS-Cog, using patient-based judgement as an anchor, and determining the minimal clinically relevant difference between change on two treatments are required. http://clinicalTrials.gov Identifier: NCT00106899.

  2. Particular application of methods of AdaBoost and LBP to the problems of computer vision

    OpenAIRE

    Волошин, Микола Володимирович

    2012-01-01

    The application of AdaBoost method and local binary pattern (LBP) method for different spheres of computer vision implementation, such as personality identification and computer iridology, is considered in the article. The goal of the research is to develop error-correcting methods and systems for implements of computer vision and computer iridology, in particular. This article considers the problem of colour spaces, which are used as a filter and as a pre-processing of images. Method of AdaB...

  3. 75 FR 45661 - Notice of Permanent Closure on Public Lands in Ada County, ID

    Science.gov (United States)

    2010-08-03

    ... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLIDB00100 L17110000.PH0000 241A 4500013040] Notice of Permanent Closure on Public Lands in Ada County, ID AGENCY: Bureau of Land Management, Interior.../2\\NW\\1/4\\ NW\\1/4\\ and N\\1/2\\SW\\1/4\\ NW\\1/4\\ of Section 32, T.1 S., R.3 E., Boise Meridian, Ada...

  4. Gender-specific association of ADA genetic polymorphism with human longevity.

    Science.gov (United States)

    Napolioni, Valerio; Lucarini, Nazzareno

    2010-08-01

    Aim of this study was to investigate whether the polymorphic ADA (Adenosine Deaminase, EC 3.5.4.4) gene, which determines the cellular level of adenosine and plays a crucial role in the regulation of the immune system and in the control of metabolic rates, is involved in longevity. 884 unrelated healthy individuals (age range 10-106 years, 400 males and 484 females) from central Italy were studied. ADA genotyping was performed by RFLP-PCR. Frequency distributions were compared using the chi-square test and a three-way contingency table analysis by a log linear model was applied to test independence between the variables. We found that ADA influences human life-span in a sex and age specific way. An increased frequency of ADA*2 carriers was found in males aged 80-85, and a decreased frequency in males over 85 (chi(2) = 13.93; df = 3; P = 0.003); significant differences among the age groups was not found in females. A strong interaction among age groups, ADA genotype and sex (G = 15.086; df = 3; P = 0.0017) was found. Males aged 80-85 could be protected from ischemic stroke by higher levels of adenosine (determined by the ADA*2 allele). The decrease of ADA*2 carriers in males over 85 may depend essentially on immunological factors; reduced levels of adenosine protect from asthma and other pulmonary diseases and lead to a reduced activation of inflammatory cells and pro-inflammatory cytokines production. Moreover, the low level of adenosine may potentiate the activity of NK and other cellular effectors against tumor cells. The negligible effect of ADA genetic polymorphism in females suggest a marginal influence of genetic factors in determining longevity in this sex, confirming previous reports.

  5. [Synthesis of a supermolecular nanoparticle γ-hy-PC/Ada-Dox and its antitumor activity].

    Science.gov (United States)

    Li, Yong-bin; Wang, Kai; Hu, Tian-nan; Wang, Qi-wen; Hu, Qi-da; Zhou, Jun; Hu, Xiu-rong; Tang, Gu-ping

    2012-11-01

    To synthesize a (2-Hydroxypropyl)-γ-cyclodextrin-polyethylenimine/adamantane-conjugated doxorubicin (γ-hy-PC/Ada-Dox) based supramolecular nanoparticle with host-guest interaction and to identify its physicochemical characterizations and antitumor effect. A novel non-viral gene delivery vector γ-hy-PC/Ada-Dox was synthesized based on host-guest interaction. 1H-NMR, NOESY, UV-Vis, XRD and TGA were used to confirm the structure of the vector. The DNA condensing ability of complexes was investigated by particle size, zeta potential and gel retardation assay. Cytotoxicity of complexes was determined by MTT assay in BEL-7402 and SMMC-7721 cells. Cell wound healing assay was performed in HEK293 and BEL-7404 cells. The transfection efficiency was investigated in HEK293 cells. H/E staining and cell uptake assay was performed in BEL-7402 cells. The structure of γ-hy-PC/Ada-Dox was characterized by 1H-NMR, NOESY, UV-Vis, XRD, TGA. The drug loading was 0.5% and 5.5%. Gel retardation assay showed that γ-hy-PC was able to completely condense DNA at N/P ratio of 2; 0.5% and 5.5% γ-hy-PC/Ada-Dox was able to completely condense DNA at N/P ratio of 3 and 4,respectively. The cytotoxicity of polymers was lower than that of PEI25KDa. The transfection efficiency of γ-hy-PC was higher than that of γ-hy-PC/Ada-Dox at N/P ratio of 30 in HEK293 cells; and the transfection efficiency was decreasing when Ada-Dox loading was increasing. Cell uptake assay showed that γ-hy-PC/Ada-Dox was able to carry drug and FAM-siRNA into cells. The novel vector γ-hy-PC/Ada-Dox has been developed successfully, which has certain transfection efficiency and antitumor activity.

  6. Predictive value of 6-month decline in ADAS-cog for survival without severe Alzheimer's disease.

    Science.gov (United States)

    Helmer, Catherine; Andrieu, Sandrine; Pérès, Karine; Orgogozo, Jean-Marc; Vellas, Bruno; Dartigues, Jean-François

    2007-01-01

    To determine the predictive value of the 6-month evolution of the ADAS-cog score in initially mild to moderate Alzheimer's disease (AD) patients on the risk of death or severe dementia (MMSE ADAS-cog scale in the Real.fr study, a cohort of AD patients. Six classes of ADAS-cog evolution were distinguished, from the severest deterioration (decline >or=7 points) to the greatest cognitive improvement (gain >or=4 points). Among 536 AD patients, 53 (9.9%) had a 6-month decline of 7 points or more. This group with the severest deterioration was significantly associated with the risk of severe dementia or death at 2 years (relative risk, RR = 3.8, 95% confidence interval, CI = 2.1-6.8), even after adjustment for baseline MMSE, disability and ADAS-cog score (RR = 2.6, 95% CI = 1.4-5.0). In addition, subjects with a decline by at least 4 points were also at greater risk of severe dementia. These results confirm the value of the ADAS-cog scale as a judgement criterion in clinical trials since it is a good surrogate marker of long-term prognosis. The proportion of fast decliners on the ADAS-cog could be a helpful judgement criterion for future trials in AD.

  7. Improved utilization of ADAS-cog assessment data through item response theory based pharmacometric modeling.

    Science.gov (United States)

    Ueckert, Sebastian; Plan, Elodie L; Ito, Kaori; Karlsson, Mats O; Corrigan, Brian; Hooker, Andrew C

    2014-08-01

    This work investigates improved utilization of ADAS-cog data (the primary outcome in Alzheimer's disease (AD) trials of mild and moderate AD) by combining pharmacometric modeling and item response theory (IRT). A baseline IRT model characterizing the ADAS-cog was built based on data from 2,744 individuals. Pharmacometric methods were used to extend the baseline IRT model to describe longitudinal ADAS-cog scores from an 18-month clinical study with 322 patients. Sensitivity of the ADAS-cog items in different patient populations as well as the power to detect a drug effect in relation to total score based methods were assessed with the IRT based model. IRT analysis was able to describe both total and item level baseline ADAS-cog data. Longitudinal data were also well described. Differences in the information content of the item level components could be quantitatively characterized and ranked for mild cognitively impairment and mild AD populations. Based on clinical trial simulations with a theoretical drug effect, the IRT method demonstrated a significantly higher power to detect drug effect compared to the traditional method of analysis. A combined framework of IRT and pharmacometric modeling permits a more effective and precise analysis than total score based methods and therefore increases the value of ADAS-cog data.

  8. Ada response - a strategy for repair of alkylated DNA in bacteria.

    Science.gov (United States)

    Mielecki, Damian; Grzesiuk, Elżbieta

    2014-06-01

    Alkylating agents are widespread in the environment and also occur endogenously. They can be cytotoxic or mutagenic to the cells introducing alkylated bases to DNA or RNA. All organisms have evolved multiple DNA repair mechanisms to counteract the effects of DNA alkylation: the most cytotoxic lesion, N(3)-methyladenine (3meA), is excised by AlkA glycosylase initiating base excision repair (BER); toxic N(1)-methyladenine (1meA) and N(3)-methylcytosine (3meC), induced in DNA and RNA, are removed by AlkB dioxygenase; and mutagenic and cytotoxic O(6)-methylguanine (O(6) meG) is repaired by Ada methyltransferase. In Escherichia coli, Ada response involves the expression of four genes, ada, alkA, alkB, and aidB, encoding respective proteins Ada, AlkA, AlkB, and AidB. The Ada response is conserved among many bacterial species; however, it can be organized differently, with diverse substrate specificity of the particular proteins. Here, an overview of the organization of the Ada regulon and function of individual proteins is presented. We put special effort into the characterization of AlkB dioxygenases, their substrate specificity, and function in the repair of alkylation lesions in DNA/RNA. © 2014 The Authors. FEMS Microbiology Letters published by John Wiley & Sons Ltd on behalf of Federation of European Microbiological Societies.

  9. Ada response – a strategy for repair of alkylated DNA in bacteria

    Science.gov (United States)

    Mielecki, Damian; Grzesiuk, Elżbieta

    2014-01-01

    Alkylating agents are widespread in the environment and also occur endogenously. They can be cytotoxic or mutagenic to the cells introducing alkylated bases to DNA or RNA. All organisms have evolved multiple DNA repair mechanisms to counteract the effects of DNA alkylation: the most cytotoxic lesion, N3-methyladenine (3meA), is excised by AlkA glycosylase initiating base excision repair (BER); toxic N1-methyladenine (1meA) and N3-methylcytosine (3meC), induced in DNA and RNA, are removed by AlkB dioxygenase; and mutagenic and cytotoxic O6-methylguanine (O6meG) is repaired by Ada methyltransferase. In Escherichia coli, Ada response involves the expression of four genes, ada, alkA, alkB, and aidB, encoding respective proteins Ada, AlkA, AlkB, and AidB. The Ada response is conserved among many bacterial species; however, it can be organized differently, with diverse substrate specificity of the particular proteins. Here, an overview of the organization of the Ada regulon and function of individual proteins is presented. We put special effort into the characterization of AlkB dioxygenases, their substrate specificity, and function in the repair of alkylation lesions in DNA/RNA. PMID:24810496

  10. Identifying Malignant Pleural Effusion by A Cancer Ratio (Serum LDH: Pleural Fluid ADA Ratio).

    Science.gov (United States)

    Verma, Akash; Abisheganaden, John; Light, R W

    2016-02-01

    We studied the diagnostic potential of serum lactate dehydrogenase (LDH) in malignant pleural effusion. Retrospective analysis of patients hospitalized with exudative pleural effusion in 2013. Serum LDH and serum LDH: pleural fluid ADA ratio was significantly higher in cancer patients presenting with exudative pleural effusion. In multivariate logistic regression analysis, pleural fluid ADA was negatively correlated 0.62 (0.45-0.85, p = 0.003) with malignancy, whereas serum LDH 1.02 (1.0-1.03, p = 0.004) and serum LDH: pleural fluid ADA ratio 0.94 (0.99-1.0, p = 0.04) was correlated positively with malignant pleural effusion. For serum LDH: pleural fluid ADA ratio, a cut-off level of >20 showed sensitivity, specificity of 0.98 (95 % CI 0.92-0.99) and 0.94 (95 % CI 0.83-0.98), respectively. The positive likelihood ratio was 32.6 (95 % CI 10.7-99.6), while the negative likelihood ratio at this cut-off was 0.03 (95 % CI 0.01-0.15). Higher serum LDH and serum LDH: pleural fluid ADA ratio in patients presenting with exudative pleural effusion can distinguish between malignant and non-malignant effusion on the first day of hospitalization. The cut-off level for serum LDH: pleural fluid ADA ratio of >20 is highly predictive of malignancy in patients with exudative pleural effusion (whether lymphocytic or neutrophilic) with high sensitivity and specificity.

  11. Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes.

    Science.gov (United States)

    Lee, Kenneth K; Sardiu, Mihaela E; Swanson, Selene K; Gilmore, Joshua M; Torok, Michael; Grant, Patrick A; Florens, Laurence; Workman, Jerry L; Washburn, Michael P

    2011-07-05

    Despite the availability of several large-scale proteomics studies aiming to identify protein interactions on a global scale, little is known about how proteins interact and are organized within macromolecular complexes. Here, we describe a technique that consists of a combination of biochemistry approaches, quantitative proteomics and computational methods using wild-type and deletion strains to investigate the organization of proteins within macromolecular protein complexes. We applied this technique to determine the organization of two well-studied complexes, Spt-Ada-Gcn5 histone acetyltransferase (SAGA) and ADA, for which no comprehensive high-resolution structures exist. This approach revealed that SAGA/ADA is composed of five distinct functional modules, which can persist separately. Furthermore, we identified a novel subunit of the ADA complex, termed Ahc2, and characterized Sgf29 as an ADA family protein present in all Gcn5 histone acetyltransferase complexes. Finally, we propose a model for the architecture of the SAGA and ADA complexes, which predicts novel functional associations within the SAGA complex and provides mechanistic insights into phenotypical observations in SAGA mutants.

  12. Benchmarks of programming languages for special purposes in the space station

    Science.gov (United States)

    Knoebel, Arthur

    1986-01-01

    Although Ada is likely to be chosen as the principal programming language for the Space Station, certain needs, such as expert systems and robotics, may be better developed in special languages. The languages, LISP and Prolog, are studied and some benchmarks derived. The mathematical foundations for these languages are reviewed. Likely areas of the space station are sought out where automation and robotics might be applicable. Benchmarks are designed which are functional, mathematical, relational, and expert in nature. The coding will depend on the particular versions of the languages which become available for testing.

  13. Modularization, inter-functional integration and operational performance

    DEFF Research Database (Denmark)

    Boer, Henrike Engele Elisabeth; Boer, Harry

    2014-01-01

    for firms to indeed use product modularity beneficially, in particular inter-functional integration between manufacturing and purchasing, design and sales, respectively. The purpose of the paper is to investigate the direct performance effects of modularization, as well as the mediating effects of the three...... forms of integration in the modularization-performance relationship....

  14. Theoretical Analysis of the Relationships Between Modularity in Design and Modularity in Production

    DEFF Research Database (Denmark)

    Kubota, Flávio Issao; Hsuan, Juliana; Cauchick-Miguel, Paulo Augusto

    2017-01-01

    This paper investigates the relationships between modularity in design (MID) and modularity in production (MIP) in the automotive industry in terms of how automotive companies obtain benefits and/or drawbacks through MID/MIP relationships. A literature analysis was conducted in order to identify...... the possible relationships between MID and MIP as well as the concepts behind these connections. Sixty-one papers were identified to portray relationships between modular product architecture and modular production systems. Results show a representation of MID and MIP relationships by illustrating that many...... propositions are offered for future field research. Finally, relationships between MID and MIP might be connected with modularity’s maturity level in companies. This is a literature review paper; therefore, empirical evidence is needed to further support current findings. Future studies could analyze...

  15. Review of the Modular Administrative Structure.

    Science.gov (United States)

    Grand Valley State Colleges, Allendale, MI. Office of Institutional Analysis.

    The modular administrative structure implemented at Grand Valley State Colleges in 1973 is described as a system in which administrative affairs are divided into functional self-contained units called modules, each of which has a head or acting head who is responsible for the management of the functions contained within the module. A long-range…

  16. Modular cogeneration for commercial light industrial sector

    Energy Technology Data Exchange (ETDEWEB)

    Sakhuja, R.

    1984-01-01

    An analysis of gas utilities' efforts to market small cogeneration systems could be helpful to entrepreneurs now venturing into this area. Orders have been placed with Thermo Electron, USA for 15 Tecogen modular cogeneration units. Applications range from an airline catering kitchen to a university swimming pool. 5 figures, 1 table.

  17. Conformal branching rules and modular invariants

    International Nuclear Information System (INIS)

    Walton, M.A.

    1989-01-01

    Using the outer automorphisms of the affine algebra SU(n), we show how the branching rules for the conformal subalgebra SU(pq) contains SU(p) x SU(q) may be simply calculated. We demonstrate that new modular invariant combinations of SU(n) characters are obtainable from the branching rules. (orig.)

  18. Progress toward Modular UAS for Geoscience Applications

    Science.gov (United States)

    Dahlgren, R. P.; Clark, M. A.; Comstock, R. J.; Fladeland, M.; Gascot, H., III; Haig, T. H.; Lam, S. J.; Mazhari, A. A.; Palomares, R. R.; Pinsker, E. A.; Prathipati, R. T.; Sagaga, J.; Thurling, J. S.; Travers, S. V.

    2017-12-01

    Small Unmanned Aerial Systems (UAS) have become accepted tools for geoscience, ecology, agriculture, disaster response, land management, and industry. A variety of consumer UAS options exist as science and engineering payload platforms, but their incompatibilities with one another contribute to high operational costs compared with those of piloted aircraft. This research explores the concept of modular UAS, demonstrating airframes that can be reconfigured in the field for experimental optimization, to enable multi-mission support, facilitate rapid repair, or respond to changing field conditions. Modular UAS is revolutionary in allowing aircraft to be optimized around the payload, reversing the conventional wisdom of designing the payload to accommodate an unmodifiable aircraft. UAS that are reconfigurable like Legos™ are ideal for airborne science service providers, system integrators, instrument designers and end users to fulfill a wide range of geoscience experiments. Modular UAS facilitate the adoption of open-source software and rapid prototyping technology where design reuse is important in the context of a highly regulated industry like aerospace. The industry is now at a stage where consolidation, acquisition, and attrition will reduce the number of small manufacturers, with a reduction of innovation and motivation to reduce costs. Modularity leads to interface specifications, which can evolve into de facto or formal standards which contain minimum (but sufficient) details such that multiple vendors can then design to those standards and demonstrate interoperability. At that stage, vendor coopetition leads to robust interface standards, interoperability standards and multi-source agreements which in turn drive costs down significantly.

  19. Modular Regiospecific Synthesis of Nitrated Fatty Acids

    DEFF Research Database (Denmark)

    Hock, Katharina J.; Grimmer, Jennifer; Göbel, Dominik

    2016-01-01

    Endogenous nitrated fatty acids are an important class of signaling molecules. Herein a modular route for the efficient and regiospecific preparation of nitrooleic acids as well as various analogues is described. The approach is based on a simple set of alkyl halides as common building blocks...

  20. A Comparison of Modular Verification Techniques

    DEFF Research Database (Denmark)

    Andersen, Henrik Reif; Staunstrup, Jørgen; Maretti, Niels

    1997-01-01

    This paper presents and compares three techniques for mechanized verification of state oriented design descriptions. One is a traditional forwardgeneration of a fixed point characterizing the reachable states. The two others can utilize a modular structure provided by the designer. Onerequires...

  1. Modularization--A Road to Relevance?

    Science.gov (United States)

    Palow, William P.

    This paper describes a modular program at a community college for instructing non-science majors in college algebra. The two-course sequence is comprised of four modules each and successful completion of a module is required before a student proceeds to the next. Placement, grading policies, and scheduling are all discussed. A formative evaluation…

  2. Modular construction approach for advanced nuclear plants

    International Nuclear Information System (INIS)

    Johnson, F.T.; Orr, R.S.; Boudreaux, C.P.

    1988-01-01

    Modular construction has been designated as one of the major features of the AP600 program, a small innovative 600-MW (electric) advanced light water reactor (ALWR) that is currently being developed by Westinghouse and its subcontractors. This program is sponsored by the US Department of Energy (DOE) in conjunction with several other DOE and Electric Power Research Institute ALWR programs. Two major objectives of the AP600 program are as follows: (1) to provide a cost of power competitive with other power generation alternatives; and (2) to provide a short construction schedule that can be met with a high degree of certainty. The AP600 plant addresses these objectives by providing a simplified plant design and an optimized plant arrangement that result in a significant reduction in the number and size of systems and components, minimizes the overall building volumes, and consequently reduces the required bulk quantities. However, only by adopting a modular construction approach for the AP600 can the full cost and schedule benefits be realized from the advances made in the plant systems design and plant arrangement. Modularization is instrumental in achieving both of the above objectives, but most of all, a total modularization approach is considered absolutely essential to ensure that an aggressive construction schedule can be met with a high degree of certainty

  3. The Modular Market. Studies in Further Education.

    Science.gov (United States)

    Theodossin, Ernest

    Origins of modular courses and the module in British postcompulsory education are considered, along with characteristics of modules, credit transfer, five case studies, and marketing in further and higher education. A module is a measured part (or course) of an extended learning experience that leads to specified qualifications. A designated…

  4. Modular simulation of reefer container dynamics

    DEFF Research Database (Denmark)

    Sørensen, Kresten Kjær; Nielsen, Jens Frederik Dalsgaard; Stoustrup, Jakob

    2014-01-01

    for faults enabling preventive maintenance. In this paper the feasibility of using different simulation methods is assessed with the goal of identifying a fast but accurate method that works well in a multi-rate environment. A modular multi-rate simulation environment for a dynamical system consisting...

  5. Building blocks for modular data acquisition systems

    Energy Technology Data Exchange (ETDEWEB)

    Hoffmann, B

    1996-12-31

    The principles of building blocks for modular data acquisition systems by means of the VIC bus are discussed. Real time operating systems based on the VME environment for program development drastically reducing the time needed to develop a working system. 4 figs.

  6. Modular microfluidic system for biological sample preparation

    Science.gov (United States)

    Rose, Klint A.; Mariella, Jr., Raymond P.; Bailey, Christopher G.; Ness, Kevin Dean

    2015-09-29

    A reconfigurable modular microfluidic system for preparation of a biological sample including a series of reconfigurable modules for automated sample preparation adapted to selectively include a) a microfluidic acoustic focusing filter module, b) a dielectrophoresis bacteria filter module, c) a dielectrophoresis virus filter module, d) an isotachophoresis nucleic acid filter module, e) a lyses module, and f) an isotachophoresis-based nucleic acid filter.

  7. Modular Stellarator Reactor conceptual design study

    International Nuclear Information System (INIS)

    Miller, R.L.; Bathke, C.G.

    1983-01-01

    A conceptual design study of the Modular Stellarator Reactor is summarized. The physics basis of the approach is elucidated with emphasis on magnetics performance optimization. Key engineering features of the fusion power core are described. Comparisons with an analogous continuous-helical-coil (torsatron) system are made as the basis of a technical and economic assessment

  8. BEETLE - A modular electronics family for robotics

    CSIR Research Space (South Africa)

    Dickens, J

    2015-11-01

    Full Text Available of applications. A family of modular electronic elements is proposed to address this need. The Beautiful Embedded Electronic Logic Element (BEETLE) family of boards is designed to be compact, low cost, robust, reusable and easy to program. This allows the boards...

  9. Modular Engineering Concept at Novo Nordisk Engineering

    DEFF Research Database (Denmark)

    Moelgaard, Gert; Miller, Thomas Dedenroth

    1997-01-01

    This report describes the concept of a new engineering method at Novo Nordisk Engineering: Modular Engineering (ME). Three tools are designed to support project phases with different levels of detailing and abstraction. ME supports a standard, cross-functional breakdown of projects that facilitates...

  10. Creating Modular Platforms for Strategic Flexibility

    DEFF Research Database (Denmark)

    Sanchez, Ron

    2004-01-01

    In developing products, long‐term success depends on designing components that facilitate the creation of a family of current and future product options. Ron Sanchez emphasizes that this requires careful planning of shared technologies and production processes. The payoff is a modular approach...

  11. Modular groups in quantum field theory

    International Nuclear Information System (INIS)

    Borchers, H.-J.

    2000-01-01

    The author discusses the connection of Lagrangean quantum field theory, perturbation theory, the Lehmann-Symanzik-Zimmermann theory, Wightman's quantum field theory, the Euclidean quantum field theory, and the Araki-Haag-Kastler theory of local observables with modular groups. In this connection he considers the PCT-theorem, and the tensor product decomposition. (HSI)

  12. A Framework for Determining Product Modularity Levels

    DEFF Research Database (Denmark)

    Hvam, Lars; Herbert-Hansen, Zaza Nadja Lee; Haug, Anders

    2017-01-01

    products have been implemented in specific types companies (mostly mass producers), but little guidance exists on how to identify the right level of modularity for other types of companies (such as engineer-to-order companies). In this article, we address this gap by suggesting a framework that categorizes...

  13. Honeywell Modular Automation System Computer Software Documentation

    International Nuclear Information System (INIS)

    CUNNINGHAM, L.T.

    1999-01-01

    This document provides a Computer Software Documentation for a new Honeywell Modular Automation System (MAS) being installed in the Plutonium Finishing Plant (PFP). This system will be used to control new thermal stabilization furnaces in HA-211 and vertical denitration calciner in HC-230C-2

  14. Modular stellarator reactor conceptual design study

    International Nuclear Information System (INIS)

    Miller, R.L.; Krakowski, R.A.; Bathke, C.G.

    1983-01-01

    A conceptual design study of the Modular Stellarator Reactor is summarized. The physics basis of the approach is elucidated with emphasis on magnetics performance optimization. Key engineering features of the fusion power core are described. Comparisons with an analogous continuous-helical-coil (torsatron) system are made as the basis of a technical and economic assessment

  15. Modular Infrastructure for Rapid Flight Software Development

    Science.gov (United States)

    Pires, Craig

    2010-01-01

    This slide presentation reviews the use of modular infrastructure to assist in the development of flight software. A feature of this program is the use of model based approach for application unique software. A review of two programs that this approach was use on are: the development of software for Hover Test Vehicle (HTV), and Lunar Atmosphere and Dust Environment Experiment (LADEE).

  16. A Semantics for Modular General Logic Programs

    NARCIS (Netherlands)

    Etalle, Sandro

    1998-01-01

    Modular programs are built as a combination of separate modules, which may be developed and verified separately. Therefore, in order to reason over such programs, compositionality plays a crucial role: the semantics of the whole program must be obtainable as a simple function from the semantics of

  17. A semantics for modular general logic programs

    NARCIS (Netherlands)

    Etalle, S.

    1998-01-01

    Modular programs are built as a combination of separate modules, which may be developed and verified separately. Therefore, in order to reason over such programs, compositionality plays a crucial role: the semantics of the whole program must be obtainable as a simple function from the semantics of

  18. Modular pulse sequencing in a tokamak system

    International Nuclear Information System (INIS)

    Chew, A.C.; Lee, S.; Saw, S.H.

    1992-01-01

    Pulse technique applied in the timing and sequencing of the various part of the MUT tokamak system are discussed. The modular architecture of the pulse generating device highlights the versatile application of the simple physical concepts in precise and complicated research experiment. (author)

  19. Principles for Implementing Modularity in Healthcare

    DEFF Research Database (Denmark)

    Soffers, Ruter; Meijboom, Bert; Hsuan, Juliana

    in a modular way. We identify three principles to do so: 1) the service architecture should be decomposable; 2) a proper service specification process should be introduced; and 3) the presence of interfaces should be ensured. Followingthese principles should help policy makers as well as managers to implement...

  20. Modular action on the massive algebra

    International Nuclear Information System (INIS)

    Saffary, T.

    2005-12-01

    The subject of this thesis is the modular group of automorphisms (σ m t ) t element of R , m>0, acting on the massive algebra of local observables M m (O) having their support in O is contained in R 4 . After a compact introduction to micro-local analysis and the theory of one-parameter groups of automorphisms, which are used extensively throughout the investigation, we are concerned with modular theory and its consequences in mathematics, e.g., Connes' cocycle theorem and classification of type III factors and Jones' index theory, as well as in physics, e.g., the determination of local von Neumann algebras to be hyperfinite factors of type III 1 , the formulation of thermodynamic equilibrium states for infinite-dimensional quantum systems (KMS states) and the discovery of modular action as geometric transformations. However, our main focus are its applications in physics, in particular the modular action as Lorentz boosts on the Rindler wedge, as dilations on the forward light cone and as conformal mappings on the double cone. Subsequently, their most important implications in local quantum physics are discussed. The purpose of this thesis is to shed more light on the transition from the known massless modular action to the wanted massive one in the case of double cones. First of all the infinitesimal generatore δ m of the group (σ m t ) t element of R is investigated, especially some assumptions on its structure are verified explicitly for the first time for two concrete examples. Then, two strategies for the calculation of σ m t itself are discussed. Some formalisms and results from operator theory and the method of second quantisation used in this thesis are made available in the appendix. (orig.)