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Sample records for acute sensorineural hearing

  1. Acute sensorineural hearing loss and severe otalgia due to scrub typhus

    Directory of Open Access Journals (Sweden)

    Kim Dong-Min

    2009-10-01

    Full Text Available Abstract Background Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi. Case presentations We encountered a patient with sensorineural hearing loss complicating scrub typhus, and three patients with scrub typhus who complained of otalgia, which was sudden onset, severe, paroxysmal, intermittent yet persistent pain lasting for several seconds, appeared within 1 week after the onset of fever and rash. The acute sensorineural hearing loss and otalgia were resolved after antibiotic administration. Conclusion When patients in endemic areas present with fever and rash and have sensorineural hearing loss or otalgia without otoscopic abnormalities, clinicians should suspect scrub typhus and consider empirical antibiotic therapy.

  2. Successful treatment of acute sensorineural hearing loss with hyperbaric oxygen therapy

    Institute of Scientific and Technical Information of China (English)

    Murat Salihoglu; Ali Memis; Mesut Mutluoglu; Gunalp Uzun; Hakan Ay

    2016-01-01

    Sudden sensorineural hearing loss (SSNHL) is an important acute clinical condition in children. A specific treatment is still missing. Hyperbaric oxygen (HBO) therapy is one of the recommended treatments for SSNHL in adults. Our knowledge on the use of HBO therapy in children for SSNHL is limited. Herein, we report the successful use of HBO therapy in the management of SSNHL in a 14-year-old child.

  3. Successful treatment of acute sensorineural hearing loss with hyperbaric oxygen therapy

    Directory of Open Access Journals (Sweden)

    Murat Salihoglu

    2016-07-01

    Full Text Available Sudden sensorineural hearing loss (SSNHL is an important acute clinical condition in children. A specific treatment is still missing. Hyperbaric oxygen (HBO therapy is one of the recommended treatments for SSNHL in adults. Our knowledge on the use of HBO therapy in children for SSNHL is limited. Herein, we report the successful use of HBO therapy in the management of SSNHL in a 14-year-old child.

  4. Sudden sensorineural hearing loss.

    Science.gov (United States)

    Stew, B T; Fishpool, S J C; Williams, H

    2012-02-01

    Sudden onset sensorineural hearing loss is a medical emergency that continues to be poorly understood despite being recognized in the literature since 1944 (De Kleyn, 1944). A commonly used criterion to qualify for this diagnosis is a sensorineural hearing loss over three contiguous pure-tone frequencies of 30 dB or more that develops within 72 hours. The vast majority of cases are unilateral and the estimated annual incidence is 20 per 100 000 persons (Nosrati-Zarenoe et al, 2007). A cause for the hearing loss is only identified in up to 10% of cases but 50% of patients will improve spontaneously (Penido et al, 2009).

  5. Acupuncture as a primary and independent treatment in the acute phases of sudden sensorineural hearing loss

    Science.gov (United States)

    Jin, Yuanyuan; Lu, Ming

    2016-01-01

    Abstract Sudden sensorineural hearing loss (SSHL) is an otological emergency defined as a rapid hearing loss, seriously affects patient's social life. To data, no study has reported the treatment by acupuncture alone in the acute phase. In this report, Acupuncture and Moxibustion therapy of excitation-focus transfer is outlined. The patient was a 26-year-old young woman who had an SSHL coupled with ear fullness. The patient had no past medical history, but she had undergone variable emotions and had a history of excessive noise exposure. The patient refused to receive any medicine especially steroids and hyperbaric oxygen therapy. She just only received acupuncture treatment. Her symptoms and outcome measurements were improved every week and completely recovered after the last week. Even though the article presents a single case and is based on self-reports, there are very clear trends on how patients with SSHL responded to acupuncture treatments. PMID:27368045

  6. Sudden sensorineural hearing loss: An update

    OpenAIRE

    Goravalingappa, Ravi; Bhattacharyya, Abir K.

    1997-01-01

    For many otolaryngologists the management of acute sensorineural hearing loss is an intuitive exercise. The ideas that govern a practice is as important as treating the patients and preventing progression of the disease; this has evolved by retrospective, anecdotal reports and clinical experience rather than through prospective research. To evaluate the current literature on management of such sensorineural hearing loss, a medline search of the topic was carried out and evidence based on rece...

  7. Short-Term Outcomes of Acute Low-Tone Sensorineural Hearing Loss According to Treatment Modality

    Science.gov (United States)

    Chang, Jinkyung; Yum, Gunhwee; Im, Ha-Young; Jung, Jong Yoon; Rah, Yoon Chan

    2016-01-01

    Background and Objectives We compared improvements in hearing thresholds in acute low-tone sensorineural hearing loss (ALHL) patients after two different treatments: steroid alone and steroid and diuretic combined. We analyzed how the duration between the onset of symptoms and the initiation of treatment affected hearing loss improvement and investigated the relation between presence of vertigo in ALHL patients and ALHL progression to Ménière's disease (MD). Subjects and Methods We retrospectively analyzed the medical records of 47 ALHL patients aged 21 to 76 years. Patients received either orally administered steroid alone (n=12) or steroid and diuretic combined (n=35). We compared improvements in the two groups' hearing thresholds at three lower frequencies (125, 250, and 500 Hz) after participants had received one month of each respective treatment. Results Our two treatments did not show any statistical difference in hearing loss improvement after one month. Forty percent of ALHL patients with vertigo developed MD, which was a significantly higher rate than the 12.5% of ALHL patients without vertigo who developed MD. The shorter duration between the onset of symptoms and the initiation of treatment significantly increased improvement in the sum of lower frequency hearing threshold after one month. Conclusions The current study suggests that steroid and diuretic administered together and steroid alone similarly improve the hearing threshold in ALHL patients after one month. We concluded that patients should initiate ALHL treatment as soon as they experience symptoms. ALHL patients should also be notified of their higher risk of developing MD. PMID:27144234

  8. Acute sensorineural hearing loss associated with peginterferon and ribavirin combination therapy during hepatitis C treatment: Outcome after resumption of therapy

    Institute of Scientific and Technical Information of China (English)

    Victor K Wong; Cindy Cheong-Lee; Jo-Ann E Ford; Eric M Yoshida

    2005-01-01

    Peginterferon and ribavirin combination therapy for the treatment of hepatitis C virus (HCV) is well known to be associated with significant adverse effects. Sensorineural hearing loss, that in most cases is unilateral, has been reported as a consequence of therapy with both non-pegylated and pegylated interferon (pegIFN) but is not a well-known adverse effect. We report a 45-year-old Caucasian woman who developed acute sensorineural hearing loss 2 mo after starting therapy with pegIFN-α 2b and ribavirin for the treatment of chronic HCV, genotype 1a. She did not report the hearing loss to the hepatitis clinic until L mo,later whereupon therapy was promptly discontinued.Although her serum alanine aminotransferase (ALT)normalized and her HCV-RNA became undetectable after 12 wk of pegIFN and ribavirin therapy, after discontinuation,her HCV-RNA became detectable with significant elevations of serum ALT. Four months after initial discontinuation,the patient re-commenced pegIFN and ribavirin combination therapy. After 44 of 48 wk of therapy, the patient's liver biochemistry has normalized and the HCV-RNA is undetectable. She has not developed worsening of her hearing loss and hearing on the left-side is unaffected.Both patients and physicians should be aware that sensorineural hearing loss may occur with pegIFN therapy.Our experience suggests that re-institution of therapy is not always associated with further hearing impairment.

  9. Pediatric Sudden Sensorineural Hearing Loss.

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    Kizilay, Ahmet; Koca, Çiğdem Firat

    2016-06-01

    Sudden sensorineural hearing loss is defined as sudden unilateral or bilateral sensorineural hearing loss with at least 30 dB decrease in threshold in 3 contiguous test frequencies occurring over 72 hours or less. It is rare among children. The mechanism of the process and prognosis of the disorder remains unclear. The current incidence of sudden sensorineural hearing loss among pediatric population is unknown. The authors carried out a retrospective chart analysis of patients under 15 years of age from 2004 to 2015, who consulted to the Otolaryngology Head and Neck Surgery Department of Inonu University Medical Faculty. Age, sex, number of affected ear and side, audiometric evaluations, medical follow-up, treatment method, duration of treatment recovery, associated complaints; tinnitus and/or vertigo, presence of mumps disease were recorded for each patient. A 4-frequency pure-tone average (500, 1000, 2000, and 4000 Hz) was calculated for each ear. Complete recovery, defined as some hearing level compared with the nonaffected ear, was observed in 3 patients (21.4 %) and there was no partial hearing recovery. The hearing loss of 11 patient remained unchanged after prednisolone treatment. Two of the 11 patients had bilaterally total sensorineural hearing loss and evaluated as appropriate for cochlear implantation. Sex of patient and laterality of hearing loss were not correlated with hearing recovery. Sensorineural hearing loss among pediatrics has been the issue of otolaryngologists. The incidence, etiology, and treatment methods should be more studied.

  10. Sensorineural hearing loss in hemorrhagic dengue?

    OpenAIRE

    Bruna Natália Freire Ribeiro; Alexandre Caixeta Guimarães; Felipe Yazawa; Tammy Fumiko Messias Takara; Guilherme Machado de Carvalho; Carlos Eduardo Monteiro Zappelini

    2014-01-01

    Introduction: Dengue is an acute febrile infectious disease, with high fever followed by symptoms flu-like. Dengue hemorrhagic fever (DHF) is a vascular leak syndrome and could present spontaneous bleeding and worsening of symptoms after some days. Dengue could have some ENT manifestations, however hearing loss is not one of them. Sudden hearing loss is considered as sensorineural or perceptual hearing loss with a sudden onset in a person without other prior otological history. The relation b...

  11. Sensorineural hearing loss in Lassa fever: two case reports

    Directory of Open Access Journals (Sweden)

    Okokhere Peter O

    2009-01-01

    Full Text Available Abstract Introduction Lassa fever is an acute arena viral haemorrhagic fever with varied neurological sequelae. Sensorineural hearing loss is one of the rare complications which occur usually during the convalescent stage of the infection. Case presentation The cases of two female patients aged 19 and 43 years old, respectively, with clinical features suggestive of Lassa fever and confirmed by immunoserological/Lassa-virus-specific reverse transcriptase polymerase chain reaction are presented. Both patients developed severe sensorineural hearing loss at acute phases of the infections. Conclusion Sensorineural hearing loss from Lassa fever infections can occur in both acute and convalescent stages and is probably induced by an immune response.

  12. Sensorineural hearing loss in Lassa fever: two case reports

    Science.gov (United States)

    2009-01-01

    Introduction Lassa fever is an acute arena viral haemorrhagic fever with varied neurological sequelae. Sensorineural hearing loss is one of the rare complications which occur usually during the convalescent stage of the infection. Case presentation The cases of two female patients aged 19 and 43 years old, respectively, with clinical features suggestive of Lassa fever and confirmed by immunoserological/Lassa-virus-specific reverse transcriptase polymerase chain reaction are presented. Both patients developed severe sensorineural hearing loss at acute phases of the infections. Conclusion Sensorineural hearing loss from Lassa fever infections can occur in both acute and convalescent stages and is probably induced by an immune response. PMID:19178735

  13. Sensorineural hearing loss in children.

    LENUS (Irish Health Repository)

    Wormald, R

    2010-02-01

    The objective of the study was to examine the aetiology of sensorineural hearing loss (SNHL) in a paediatric population presenting to the National Centre of Medical Genetics. A retrospective chart review from 1998 to 2006. One hundred and twenty nine children were investigated for SNHL. The average age of diagnosis of hearing loss was 36 months. The degree of hearing loss was mild in 8 children, moderate in 33 children, severe in 31 children and profound in 57 children. Eighty-five children (66%) were diagnosed with a hereditary hearing loss, 11 (8%) children had an acquired hearing loss and no cause found in 33 (26%) children. This is the first report of the causes of hearing loss in Irish children. The mean age of diagnosis in our cohort is high and emphasises the need for a neonatal screening programme. There remains a number of children for whom the cause of hearing loss remains unknown.

  14. Methadone Induced Sensorineural Hearing Loss

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    Chadi Saifan

    2013-01-01

    Full Text Available Background. Sudden sensorineural hearing loss (SSHL caused by opiate abuse or overuse has been well documented in the medical literature. Most documented case reports have involved either heroin or hydrocodone/acetaminophen. Recently, case reposts of methadone induced SSHL have been published. Case Report. We present the case of a 31-year-old man who developed SSHL after a methadone overdose induced stupor. He was subsequently restarted on methadone at his regular dose. On follow-up audiometry exams, he displayed persistent moderately severe sensorineural hearing loss bilaterally. Discussion. This case is notable because unlike all but one previously reported case, the patient—who was restated on methadone—did not make a complete recovery. Conclusion. Methadone overuse in rare cases causes SSHL.

  15. Evidence-based practice: management of adult sensorineural hearing loss.

    Science.gov (United States)

    Chau, Justin K; Cho, John J W; Fritz, Dieter K

    2012-10-01

    Sensorineural hearing loss is a complex disease state influenced by genetics, age, noise, and many other factors. This article reviews our current knowledge regarding the causes of sensorineural hearing loss and reviews the more challenging clinical presentations of sensorineural hearing loss. We have reviewed the latest medical literature in an attempt to provide an evidence-based strategy for the assessment and management of sudden sensorineural hearing loss, rapidly progressive sensorineural hearing loss, and asymmetric/unilateral sensorineural hearing loss.

  16. Disrupted functional brain connectome in unilateral sudden sensorineural hearing loss.

    Science.gov (United States)

    Xu, Haibo; Fan, Wenliang; Zhao, Xueyan; Li, Jing; Zhang, Wenjuan; Lei, Ping; Liu, Yuan; Wang, Haha; Cheng, Huamao; Shi, Hong

    2016-05-01

    Sudden sensorineural hearing loss (SSNHL) is generally defined as sensorineural hearing loss of 30 dB or greater over at least three contiguous audiometric frequencies and within a three-day period. This hearing loss is usually unilateral and can be associated with tinnitus and vertigo. The pathogenesis of unilateral sudden sensorineural hearing loss is still unknown, and the alterations in the functional connectivity are suspected to involve one possible pathogenesis. Despite scarce findings with respect to alterations in brain functional networks in unilateral sudden sensorineural hearing loss, the alterations of the whole brain functional connectome and whether these alterations were already in existence in the acute period remains unknown. The aim of this study was to investigate the alterations of brain functional connectome in two large samples of unilateral sudden sensorineural hearing loss patients and to investigate the correlation between unilateral sudden sensorineural hearing loss characteristics and changes in the functional network properties. Pure tone audiometry was performed to assess hearing ability. Abnormal changes in the peripheral auditory system were examined using conventional magnetic resonance imaging. The graph theoretical network analysis method was used to detect brain connectome alterations in unilateral sudden sensorineural hearing loss. Compared with the control groups, both groups of unilateral SSNHL patients exhibited a significantly increased clustering coefficient, global efficiency, and local efficiency but a significantly decreased characteristic path length. In addition, the primary increased nodal strength (e.g., nodal betweenness, hubs) was observed in several regions primarily, including the limbic and paralimbic systems, and in the auditory network brain areas. These findings suggest that the alteration of network organization already exists in unilateral sudden sensorineural hearing loss patients within the acute period

  17. Sensorineural hearing loss in chronic otitis media.

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    MacAndie, C; O'Reilly, B F

    1999-06-01

    Although many studies have demonstrated an association between chronic otitis media (COM) and sensorineural hearing loss (SNHL), there still remains disagreement about the relationship. A retrospective study was conducted to examine the relationship between sensorineural hearing loss and chronic otitis media. Forty-one patients met the following criteria: unilateral COM and no history of head injury, meningitis or previous otological surgery. The differences in preoperative bone conduction threshold between diseased and control (contralateral normal) ear were statistically significant (P ossicular erosion was not associated with a significantly increased risk of sensorineural hearing loss. PMID:10384849

  18. Sudden (reversible) sensorineural hearing loss in pregnancy.

    LENUS (Irish Health Repository)

    Kenny, R

    2011-03-01

    Sudden hearing loss directly associated with pregnancy or birth is a little known and rare occurrence. The temporary, unilateral, low-frequency sensorineural hearing loss in this case was reported after the birth of the patient\\'s first child, and again during the third trimester of her second pregnancy.

  19. Gd enhanced MRI in sensorineural hearing loss

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    Takenaka, Mika; Tono, Tetsuya; Toyama, Katsuhiro; Kano, Kiyo; Morimitsu, Tamotsu [Miyazaki Medical Coll., Kiyotake (Japan)

    1996-09-01

    The enhanced MRI hearing findings of the inner ear in 124 patients with sensorineural hearing loss were evaluated. MR images were obtained before and after the intravenous administration of gadolinium (0.1 mmol/kg). In three out of seventy-nine patients with unilateral healing loss, cochlear and/or the vestibular enhancement was noted on the symptomatic side. The positive cases included those with Ramsay-Hunt syndrome, mumps and so-called sudden deafness. Forty-five patients with bilateral hearing loss showed no enhancement within the inner ear. Although positive gadolinium enhancement of the inner ear may detect inflammatory lesions due to a viral infection, its incidence in sensorineural hearing loss, including cases of sudden deafness. seems to be extremely rare. (author)

  20. SUDDEN ONSET SENSORINEURAL HEARING LOSS: MANAGEMENT PROTOCOL

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    Anil Kumar

    2016-06-01

    Full Text Available AIMS To study the efficacy of transcutaneous nitroglycerin and pulse steroid injection in patients with sudden hearing loss. MATERIAL AND METHOD This was a prospective study conducted in the Department of ENT, KIMS, Bhubaneswar; 31 patients who fit to inclusion criteria included in this study. RESULTS Out of 31 patients of sudden onset sensorineural hearing loss, 18 (58.06% patients had threshold closer to 30 dB.

  1. Sensorineural hearing loss in Lassa fever: two case reports

    OpenAIRE

    Okokhere Peter O; Ibekwe Titus S; Akpede George O

    2009-01-01

    Abstract Introduction Lassa fever is an acute arena viral haemorrhagic fever with varied neurological sequelae. Sensorineural hearing loss is one of the rare complications which occur usually during the convalescent stage of the infection. Case presentation The cases of two female patients aged 19 and 43 years old, respectively, with clinical features suggestive of Lassa fever and confirmed by immunoserological/Lassa-virus-specific reverse transcriptase polymerase chain reaction are presented...

  2. Sensorineural hearing loss in hemorrhagic dengue?

    Directory of Open Access Journals (Sweden)

    Bruna Natália Freire Ribeiro

    2015-01-01

    Discussion and conclusion: This is the first case report that brings together DHF and sudden hearing loss. In the development of this case no other cause to sudden hearing loss was found and the correlation between dengue and hearing loss was questioned. In the literature review was found that some viruses, as mumps virus, varicella-zoster virus and HSV-1 and HSV-2 are related to sudden hearing loss, all of them fit in the viral theory. Besides the viral theory of sudden hearing loss, there is the vascular theory that is the occlusion of the end artery that supplies the cochlea. DHF has a vascular commitment, and the hypothesis of a vascular cause could be elicited in this case. Many studies in this area are needed and this article has the objective of elicit the discussion about the subject. Could dengue be associated with sensorineural hearing loss?

  3. Sensorineural hearing loss after magnetic resonance imaging

    DEFF Research Database (Denmark)

    Mollasadeghi, Abolfazl; Mehrparvar, Amir Houshang; Atighechi, Saeid;

    2013-01-01

    Magnetic resonance imaging (MRI) devices produce noise, which may affect patient's or operators' hearing. Some cases of hearing impairment after MRI procedure have been reported with different patterns (temporary or permanent, unilateral or bilateral, with or without other symptoms like tinnitus)......). In this report, a case of bilateral sensorineural hearing loss in an otherwise healthy patient underwent brain MRI was described. The patient's hearing loss was accompanied with tinnitus and was not improved after 3 months of followup.......Magnetic resonance imaging (MRI) devices produce noise, which may affect patient's or operators' hearing. Some cases of hearing impairment after MRI procedure have been reported with different patterns (temporary or permanent, unilateral or bilateral, with or without other symptoms like tinnitus...

  4. Sudden Sensorineural Hearing Loss: Primary Care Update.

    Science.gov (United States)

    Leung, Marcia A; Flaherty, Anna; Zhang, Julia A; Hara, Jared; Barber, Wayne; Burgess, Lawrence

    2016-06-01

    The primary care physician's role in recognizing sudden sensorineural hearing (SSNHL) loss and delivering initial treatment is critical in the management of the syndrome. This role involves recognizing its clinical symptoms, distinguishing it from conductive hearing loss with the Weber tuning fork or the Rauch hum test, and urgent administration of high dose oral corticosteroids. Diagnosis and treatment should not be delayed for audiometric testing or referral to otolaryngology. This paper provides an update on the initial evaluation and treatment of this syndrome based on the literature and clinical guideline recommendations.

  5. Sudden Sensorineural Hearing Loss; Prognostic Factors

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    Arjun Dass

    2015-09-01

    Full Text Available Introduction: Sudden sensorineural hearing loss (SSNHL is a frightening and frustrating symptom for the patient as well as the physician. Prognosis is affected by multiple factors including duration of hearing loss, presence of associated vertigo and tinnitus, and co-morbidities such as hypertension and diabetes.   Materials and Methods: Forty subjects presenting to our department with features of sudden hearing loss were included in the study. Detailed otological history and examination, serial audiometric findings and course of disease were studied.   Results: Subjects presenting late (in older age, having associated vertigo, hypertension and diabetes had a significantly lower rate of recovery.   Conclusion:  Only 60–65% of patients experiencing SSNHL recover within a period of 1 month; this rate is further affected by presence of multiple prognostic indicators.

  6. Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss

    Institute of Scientific and Technical Information of China (English)

    Yong-qiang Yu; Huai-an Yang; Ming Xiao; Jing-wei Wang; Dong-yan Huang; Yagesh Bhambhani; Lyn Sonnenberg

    2015-01-01

    In this article, the mechanism of inheritance behind inherited hearing loss and genetic susceptibility in noise-induced hearing loss are reviewed. Conventional treatments for sensorineural hearing loss (SNHL), i.e. hearing aid and cochlear implant, are effective for some cases, but not without limitations. For example, they provide little benefit for patients of profound SNHL or neural hearing loss, especially when the hearing loss is in poor dynamic range and with low frequency resolution. We emphasize the most recent evidence-based treatment in this field, which includes gene therapy and allotransplantation of stem cells. Their promising results have shown that they might be options of treatment for profound SNHL and neural hearing loss. Although some treatments are still at the experimental stage, it is helpful to be aware of the novel therapies and endeavour to explore the feasibility of their clinical application.

  7. Clinical observation of acute low frequency sensorineural hearing loss%急性低频感音神经性耳聋的临床观察

    Institute of Scientific and Technical Information of China (English)

    刘寒波; 彭增龙; 胡建平; 邓璟; 林湘如; 吴雄文; 黎可华

    2012-01-01

    目的 探讨急性低频感音神经性耳聋(acute low-tone sensorineural hearing loss,ALHL)的临床特点和疗效,提高对该疾病的诊断和认识.方法 回顾性分析62例ALHL患者的临床表现、听力学检查和治疗情况,总结其临床发展规律.结果 发病年龄以青中年为主,女性明显多于男性,多为单耳发病,表现为耳闷或伴耳鸣,听力下降,不伴眩晕,所有患者纯音听阈均表现为轻中度低频感音神经性耳聋,治疗前后分别为(38.71±6.82)dB和(20.56±9.44)dB,两者比较差异具有统计学意义(P<0.05).鼓室图“A”型,49例(80.9%)镫骨肌反射引出,40例(64.5%) Metz试验阳性,62例ABR均正常.62例患者治疗前DPOAE在0.5~1 kHz的引出率仅为18.7%,反应幅值明显降低,治疗后DPOAE在0.5 ~1 kHz的引出率提高至43.8%,幅值亦有所提高.结论 ALHL以突发的耳闷和(或)伴耳鸣为主要表现,常单耳发病,青中年女性为主,听力学定位诊断为蜗性聋,仅累及低频区,皮质类固醇激素治疗有较好的疗效.%Objective To investigate the clinical features and curative effect of the acute low - tone sensorineural hearing loss ( ALHL) , and to improve the diagnosis and understanding. Methods Retrospective analysis of 62 cases of the clinical manifestations of ALHL, audiological examination and treatment was carried out to sum up the clinical development pattern. Results The age of onset in young and middle-aged female dominated, significantly more than men, mostly single ear morbidity, symptoms of aural fullness or/with tinnitus, hearing loss, not all patients with vertigo, pure tone audiometry showed mild to moderate low frequency sensorineural hearing loss (38.71 ± 6. 82) dB and (20. 56 ± 9. 44 ) dB before and after treatment respectively. The difference was statistically significant ( P < 0. 05 ). Tympanogram was " A" type in 49 cases ( 80. 9% ) the siapedius reflex elicitated in 40 cases (64. 5% ) . Metz test was positive, ABR

  8. Clinical evaluation of acute low-tone sensorineural hearing loss%急性低频感音神经性聋的临床分析

    Institute of Scientific and Technical Information of China (English)

    林琳; 唐安洲

    2011-01-01

    目的:评估急性低频感音神经性聋的临床疗效以及相关因素对预后的影响.方法:从398例突发性聋患者中筛选出41例急性低频听力下降者,分析经糖皮质激素等综合治疗后的效果,探讨患者的性别、病程和发病年龄与疗效的相关性.结果:急性低频感音神经性聋占突发性聋的10.30%,其中女性患者占70.73%,明显高于男性.初诊时3个低频和3个高频的平均听阈分别为(48.43士11.67)dB和(18.86士9.40)dB,治疗后复查,3个低频和3个高频的平均听阈分别为(27.07士11.52)dB和(17.60士9.15)dB,治疗前3个低频与3个高频的平均听阈相比差异有统计学意义(t=15.42,P0.05).治愈率和有效率均差异无统计学意义(均P>0.05).21~40岁年龄段发病人数占总数的68.29%,≤40岁与41~60岁患者的治愈率差异有统计学意义(X2=6.662,P0.05).患者在发病7 d内就诊与>7 d就诊的治愈率和有效率差异均无统计学意义(均P>0.05).结论:急性低频感音神经性聋采用糖皮质激素等综合治疗疗效较好,疗效未见性别差异,病程的长短与预后未见明显差异,发病的年龄与预后有关.%Objective:To assess the effect of treatment on acute low-tone sensorineural hearing loss and the re-lated factors on the prognosis. Method: A total of 398 inpatients with sudden deafness were retrospectively ana-lyzed. Among them, 41 cases were diagnosed as acute low-tone hearing loss and then subjected to combined treat-ment with glucocorticoids. The relativity between patients' gender, disease duration and age of onset and curative effect were analyzed. Result:The acute low-tone sensorineural hearing loss accounted for 10. 30% of sudden deaf-ness. Among which, female cases were significantly more than men, accounting for 70. 73% of the total. At the first diagnosis, the average hearing threshold of three low tones was(48. 43±11. 67) dB against(18. 86 ± 9. 40)dB of three high tones. After treatment, those two values

  9. Diclofenac induced sudden sensorineural hearing loss

    Directory of Open Access Journals (Sweden)

    M Bhanukumar

    2015-07-01

    Full Text Available A few cases of mild to moderate, gradual and reversible sensorineural hearing loss (SNHL with prolonged doses of nonsteroidal anti-inflammatory drugs has been reported. We present a case of sudden irreversible SNHL in a 60-year-old female after taking a single dose of diclofenac. The patient was a known case of diabetes mellitus and hypertension and was on regular treatment. We postulate that the patient's hearing loss was the result of diclofenac's ototoxic effects which may have been potentiated as a result of her long standing diabetes, hypertension and old age. Accordingly, we recommend the cautious use of diclofenac in patients with underlying diseases where diclofenac induced ototoxicity could potentially result in adverse otologic consequences.

  10. Studying VEMP in Sudden Sensorineural Hearing Loss

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    Mohsen Rajati

    2011-03-01

    Full Text Available Introduction: Sudden sensorineural hearing loss (SSNHL has a prevalence of 10 in 100,000. Viral infections, vascular obstruction and rupture of the intracochlear membranes are supposed to be its most common etiologies. About 40% of patients experience vertigo or imbalance. The VEMP (vestibular evoked myogenic potentials test is a known approach for detailed study of the labyrinth. The advantage of this test in comparison to other tests is the selected study of sacculus and sacculocochlear pathways. Materials and Methods:  In this cross sectional study all patients with SSNHL diagnosis were admitted and underwent routine standard treatments and diagnostic tests. Clinical symptoms and paraclinic findings were recorded in especially designed forms and VEMP test was performed on admission. Results: Among the 43 cases with sudden sensorineural hearing loss, 14 (32.6% had vertigo. Thirteen patients (39.2% out of 43 had a negative (abnormal VEMP, 6 of which (42.9% had vertigo, while in the 30 VEMP positive (normal cases, vertigo was detected in 8 (26.6%. Discussion: Saccular dysfunction seems to be an important finding in SSNHL. Although it is more prevalent in the patients with vertigo, it can be found in the non-dizzy cases. VEMP disturbance in SSNHL shows more extensive pathological involvement. Conclusion: In SSNHL the pathology isn’t limited to the cochlea and even in patients with no vestibular symptoms sacculus might be involved.

  11. Sensorineural hearing loss in Kawasaki disease.

    Science.gov (United States)

    Aggarwal, Varun; Etinger, Veronica; Orjuela, Andres F

    2016-01-01

    Kawasaki disease is a common nonspecific vasculitis seen in childhood. The most significant long-term sequela is coronary artery aneurysm. However, the spectrum of complications involves not only the heart, but also other organs such as the eyes, skin, kidneys, gallbladder, liver, and central nervous system. Sensorineural hearing loss (SNHL) is a relatively unrecognized complication of the disease. Although most of the complications (except coronary artery aneurysm) are self-limiting, SNHL can be persistent. It is, especially important in infants and young children who might not be able to report the hearing deficits and are most likely to have cognitive and speech delays if this hearing loss is not addressed in a timely manner. We report a child with Kawasaki disease who had SNHL during the 2(nd) week of the illness. The aim of this article is to briefly review the pathophysiology behind this hearing loss and strongly emphasize the importance of universal hearing evaluation in all children diagnosed with Kawasaki disease. This screening in children with Kawasaki disease may provide some timely intervention if needed. Since most Kawasaki disease patients will be seen by cardiologists, we hope to create more awareness about this complication to the cardiology community as well. PMID:27011703

  12. Sensorineural hearing loss in Kawasaki disease

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    Varun Aggarwal

    2016-01-01

    Full Text Available Kawasaki disease is a common nonspecific vasculitis seen in childhood. The most significant long-term sequela is coronary artery aneurysm. However, the spectrum of complications involves not only the heart, but also other organs such as the eyes, skin, kidneys, gallbladder, liver, and central nervous system. Sensorineural hearing loss (SNHL is a relatively unrecognized complication of the disease. Although most of the complications (except coronary artery aneurysm are self-limiting, SNHL can be persistent. It is, especially important in infants and young children who might not be able to report the hearing deficits and are most likely to have cognitive and speech delays if this hearing loss is not addressed in a timely manner. We report a child with Kawasaki disease who had SNHL during the 2 nd week of the illness. The aim of this article is to briefly review the pathophysiology behind this hearing loss and strongly emphasize the importance of universal hearing evaluation in all children diagnosed with Kawasaki disease. This screening in children with Kawasaki disease may provide some timely intervention if needed. Since most Kawasaki disease patients will be seen by cardiologists, we hope to create more awareness about this complication to the cardiology community as well.

  13. Constraint-induced sound therapy for sudden sensorineural hearing loss--behavioral and neurophysiological outcomes.

    Science.gov (United States)

    Okamoto, Hidehiko; Fukushima, Munehisa; Teismann, Henning; Lagemann, Lothar; Kitahara, Tadashi; Inohara, Hidenori; Kakigi, Ryusuke; Pantev, Christo

    2014-01-29

    Sudden sensorineural hearing loss is characterized by acute, idiopathic hearing deterioration. We report here the development and evaluation of "constraint-induced sound therapy", which is based on a well-established neuro-rehabilitation approach, and which is characterized by the plugging of the intact ear ("constraint") and the simultaneous, extensive stimulation of the affected ear with music. The sudden sensorineural hearing loss patients who received the constraint-induced sound therapy in addition to the standard corticosteroid therapy showed significantly better recovery of hearing function compared to those who had only received corticosteroid treatments. Additionally, the brain activity obtained in a subgroup of patients suggested that the constraint-induced sound therapy could have prevented maladaptive auditory cortex reorganization. Constraint-induced sound therapy thus appears to be an effective, practical, and safe treatment option for sudden sensorineural hearing loss.

  14. [The experience with the use of neuromedin preparations for the treatment of sensorineural impairment of hearing].

    Science.gov (United States)

    Tambovtseva, O V; Platonova, I S; Vankova, S N; Ushkov, E V; Vorozheĭkina, N G; Turkina, T A

    2014-01-01

    The objective of the present study was to evaluate the effectiveness of the application of neuromedin for the treatment of sensorineural loss of hearing of different etiology. A total of 230 patients at the age varying from 20 to 60 years presenting with sensorineural impairment of hearing were available for the observation. Neuromedin was administered intramuscularly at 15 mg/day (1.5% solution at a dose of 1.0 ml) for 10 day; thereafter, the patients took 20 mg neuromedin tablets thrice daily during one month. The majority of the patients reported an improvement of hearing and speech intelligibility. Complete restoration of hearing was documented in certain patients presenting with acute sensorineural impairment of hearing. PMID:25588490

  15. Treatment of acute unilateral low-frequency sensorineural hearing loss%急性单侧低频感音神经性聋的治疗探讨

    Institute of Scientific and Technical Information of China (English)

    窦艳玲; 冯怀志; 刘涛

    2013-01-01

    Objective To discuss the clinical characteristics and treatment of acute low -frequency sensorineural hearing loss (ALHL). Methods A retrospective analysis was made in the clinical data of 53 patients with ALHL. In hospitalization group,there were 38 cases (38 ears) ,and in out-patient group,there were 15 cases (15 ears). The hospitalization group orally took prednisone 1 mg/kg for 5 d and also received vasodilator and neurotrophic agents at the same time . The outpatient group only received prednisone 20 mg/kg. One week later, these patients were re-examined for hearing, and the curative effects were evaluated. Results In the hospitalization group ,the effective rate was 89. 5% (34/38 ) , and the cure rate was 65. 8% ( 25/38 ). In the out-patient group , the effective rate was 80.0% (12/15) ,and the cure rate was 53. 3% (8/15). There was no significant difference of the curative effects between the two groups (P>0.05). Conclusion Acute low-requency sensorineural hearing loss is an independent disease which is different from sudden hearing loss. Its pathogenesis may have close correlation with meniere disease . Outpatient treatment with small dose of corticosteroid hormone is effective.%目的 探讨急性低频感音神经性聋的临床特点及治疗.方法 回顾分析53例急性低频感音神经性聋患者临床资料,其中住院组38例(耳),门诊组15例(15耳),住院组口服强的松1 mg/kg×5 d,加用血管扩张剂和神经营养剂治疗;门诊组仅口服强的松片20 mg/d×5 d.1 w后复查听力,评估疗效.结果 住院组的有效率89.5%(34/38),治愈率65.8%(25/38),门诊组有效率80.0%(12/15),治愈率53.3%(8/15),两组间的疗效比较差异无统计学意义(P>0.05).结论 急性低频感音神经性聋是一种有别于突发性耳聋的独立疾病,其发病机制可能与梅尼埃病关系密切,小剂量皮质类固醇激素门诊治疗有效.

  16. Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss.

    Science.gov (United States)

    Sekiya, Kenichi; Fukushima, Munehisa; Teismann, Henning; Lagemann, Lothar; Kakigi, Ryusuke; Pantev, Christo; Okamoto, Hidehiko

    2016-01-25

    Sudden sensorineural hearing loss (SSHL) is characterized by acute, idiopathic hearing loss. The estimated incidence rate is 5-30 cases per 100,000 people per year. The causes of SSHL and the mechanisms underlying SSHL currently remain unknown. Based on several hypotheses such as a circulatory disturbance to the cochlea, viral infection, and autoimmune disease, pharmaco-therapeutic approaches have been applied to treat SSHL patients; however, the efficacy of the standard treatment, corticosteroid therapy, is still under debate. Exposure to intense sounds has been shown to cause permanent damage to the auditory system; however, exposure to a moderate level enriched acoustic environment after noise trauma may reduce hearing impairments. Several neuroimaging studies recently suggested that the onset of SSHL induced maladaptive cortical reorganization in the human auditory cortex, and that the degree of cortical reorganization in the acute SSHL phase negatively correlated with the recovery rate from hearing loss. This article reports the development of a novel neuro-rehabilitation approach for SSHL, "constraint-induced sound therapy (CIST)". The aim of the CIST protocol is to prevent or reduce maladaptive cortical reorganization by using an enriched acoustic environment. The canal of the intact ear of SSHL patients is plugged in order to motivate them to actively use the affected ear and thereby prevent progress of maladaptive cortical reorganization. The affected ear is also exposed to music via a headphone for 6 hr per day during hospitalization. The CIST protocol appears to be a safe, easy, inexpensive, and effective treatment for SSHL.

  17. Disacusia neurossensorial imunomediada Immunomediated sensorineural hearing loss

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    Norma de Oliveira Penido

    2002-10-01

    Full Text Available A disacusia neurossensorial imunomediada (DNSI é caracterizada geralmente por uma disacusia neurossensorial bilateral, progressiva e assimétrica, acompanhada ou não por outros sintomas da orelha interna. Três pacientes com DNSI cujo quadro clínico e audiométrico eram sugestivos de doença auto-imune, e apresentaram resposta positiva à terapia imunossupressora ou pesquisa positiva de anticorpo anti hsp-70 68kD, foram estudados com relação às características clínicas, testes diagnósticos, alternativas terapêuticas e evolução da doença. Dois pacientes apresentaram quadro de disacusia neurossensorial rapidamente progressiva, associado a quadro vestibular, e outro, quadro de surdez súbita unilateral. Nenhum paciente apresentou positividade às provas reumatológicas, e apenas um paciente apresentou aumento na velocidade de hemossedimentação. Nenhum paciente obteve resposta adequada sustentada à corticoterapia, mas dois deles melhoraram com outras terapias imunossupressoras. O diagnóstico da DNSI é clínico e baseado na resposta positiva ao teste terapêutico com imunossupressores. A pesquisa de anticorpo anti-hsp70 de 68 kD pelo Western Blot é o único exame laboratorial específico para seu diagnóstico, possuindo sensibilidade de 42% e especificidade de 90%. Apenas 1 paciente apresentou positividade para este teste e não respondeu à terapia imunossupressora. Os dois pacientes com teste negativo responderam satisfatoriamente ao tratamento. A baixa sensibilidade do Western Blot e seu alto custo dificultam sua difusa utilização em nosso meio. A introdução precoce do tratamento é de suma importância por auxiliar no diagnóstico e por proporcionar um melhor prognóstico auditivo.The immunomediated sensorineural hearing loss (ISHL is characterized as an asymmetric and progressive sensorineural hearing loss. Tree patients with ISHL were studied, regarding clinical aspects, diagnostic tests, treatment options and disease

  18. Idiopathic sensorineural hearing loss in the only hearing ear.

    Science.gov (United States)

    Berrettini, S; De Vito, A; Bruschini, L; Fortunato, S; Forli, F

    2016-04-01

    A retrospective chart review was used for 31 patients with sudden, progressive or fluctuating sensorineural hearing loss (SHL) in the only hearing ear who had been consecutively evaluated at the ENT, Audiology and Phoniatrics Unit of the University of Pisa. The group of patients was evaluated with a complete history review, clinical evaluation, imaging exam (MRI, CT), audiologic tests (tone and speech audiometry, tympanometry, study of stapedial reflexes, ABR and otoacoustic emission) evaluation. In order to exclude genetic causes, patients were screened for CX 26 and CX30 mutations and for mitochondrial DNA mutation A1555G. Patients with sudden or rapidly progressive SHL in the only hearing ear were treated with osmotic diuretics and corticosteroids. In patients who did not respond to intravenous therapy we performed intratympanic injections of corticosteroid. Hearing aids were fitted when indicated and patients who developed severe to profound SHL were scheduled for cochlear implant surgery. The aim of this study is to report and discuss the epidemiology, aetiopathogenesis, therapy and clinical characteristic of patients affected by SHL in the only hearing hear and to discuss the issues related to the cochlear implant procedure in some of these patients, with regard to indications, choice of the ear to implant and results.

  19. Weather conditions and sudden sensorineural hearing loss

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    Kateri Maria

    2002-07-01

    Full Text Available Abstract Background Climatic or meteorological condition changes have been implicated in the pathogenesis of Idiopathic Sudden Sensorineural Hearing Loss (ISSHL. We investigated the seasonal distribution of ISSHL and evaluated the influence of meteorological parameters (such as temperature, humidity, and atmospheric pressure, their variation and covariation on the incidence of the disease. Methods A total of 82 cases of ISSHL, admitted to our department over a five-year period, were enrolled in the study. Seasonal distribution of the disease was investigated by dividing the year in four seasons. Meteorological data included daily values of 13 distinct parameters recorded at the meteorological station of the University of Ioannina during this period. A relationship between each meteorological variable and the incidence of ISSHL was investigated by applying (χ2 test on data from 13 contingency tables as well as by using logistic regression and t-test approaches. In addition, the influence of different weather types on the incidence of ISSHL was investigated using Cluster Analysis in order to create eight clusters (weather types characteristic for the prefecture of Ioannina. Results The results of the study could not indicate any seasonal distribution of the disease. The incidence of ISSHL could not be significantly correlated either to any distinct meteorological parameter or to any specific weather type. Conclusions Meteorological conditions, such as those dominating in the Northwestern Greece, and/or their changes, have no proven effect on the incidence of ISSHL.

  20. Scleroderma and sudden sensorineural hearing loss

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    Ravinder Verma

    2014-01-01

    Full Text Available Sudden sensorineural hearing loss (SNHL is an emergency in otolaryngological practice. The exact cause, in most of the cases cannot be found. A triad of vascular, viral, and membrane rupture are the known theories for the causation of sudden SNHL. Now various autoimmune disorders have also been suggested to play a role in the pathogenesis. Autoimmune inner ear disease in human being is an uncommon, but a distinct clinical entity. The diagnosis of the inner ear autoimmune disorder depends mainly on relatively distinct clinical course, immune laboratory tests and treatment response. The clinical picture usually consists of bilateral SNHL, bilateral reduced vestibular loss and symptoms of pressure with tinnitus and rarely tissue destruction of middle and external ear. Systemic scleroderma is an aggressive multi-system and multistage connective tissue disorder with high mortality. It is characterized by proliferative vascular lesion and marked deposition of collagen in various tissues and organs. Responses to immunosuppressive drugs are cited as evidence of an autoimmune process.

  1. Early-onset sensorineural hearing loss in Lassa fever.

    Science.gov (United States)

    Ibekwe, T S; Okokhere, P O; Asogun, D; Blackie, F F; Nwegbu, M M; Wahab, K W; Omilabu, S A; Akpede, G O

    2011-02-01

    Lassa fever (LF) is a viral hemorrhagic disease which affects one-fourth to two million people annually with the fatality rate of about 10,000. It is associated with sensorineural hearing loss (SNHL) usually at the convalescent stage. Recently, cases of SNHL at the acute phase have been reported. This study was done to further investigate the incidence and features of SNHL in acute phase of LF. It is a prospective case-control study of LF patients seen with acute SNHL conducted between July 2007 and April 2009 at Irrua Specialist Teaching Hospital Nigeria. The diagnosis of acute LF was based on the clinical features and detection of IgM antibodies and/or positive Lassa virus-specific reverse transcriptase-polymerase chain reaction using primers S36+ and LVS 339 while SNHL was diagnosed clinically and confirmed with PTA and speech discrimination tests. Patients with other acute febrile illnesses were used as control. Statistical analysis was done using SPSS version 11 and Fisher's exact test while level of significance was set at p 0.05). The incidence of SNHL in LF infection is about 13.5% and could be a reflection of a worse disease process. There is possibility of direct viral invasion aside immunological reaction as a causative mechanism. PMID:20809263

  2. Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss.

    Science.gov (United States)

    Sekiya, Kenichi; Fukushima, Munehisa; Teismann, Henning; Lagemann, Lothar; Kakigi, Ryusuke; Pantev, Christo; Okamoto, Hidehiko

    2016-01-01

    Sudden sensorineural hearing loss (SSHL) is characterized by acute, idiopathic hearing loss. The estimated incidence rate is 5-30 cases per 100,000 people per year. The causes of SSHL and the mechanisms underlying SSHL currently remain unknown. Based on several hypotheses such as a circulatory disturbance to the cochlea, viral infection, and autoimmune disease, pharmaco-therapeutic approaches have been applied to treat SSHL patients; however, the efficacy of the standard treatment, corticosteroid therapy, is still under debate. Exposure to intense sounds has been shown to cause permanent damage to the auditory system; however, exposure to a moderate level enriched acoustic environment after noise trauma may reduce hearing impairments. Several neuroimaging studies recently suggested that the onset of SSHL induced maladaptive cortical reorganization in the human auditory cortex, and that the degree of cortical reorganization in the acute SSHL phase negatively correlated with the recovery rate from hearing loss. This article reports the development of a novel neuro-rehabilitation approach for SSHL, "constraint-induced sound therapy (CIST)". The aim of the CIST protocol is to prevent or reduce maladaptive cortical reorganization by using an enriched acoustic environment. The canal of the intact ear of SSHL patients is plugged in order to motivate them to actively use the affected ear and thereby prevent progress of maladaptive cortical reorganization. The affected ear is also exposed to music via a headphone for 6 hr per day during hospitalization. The CIST protocol appears to be a safe, easy, inexpensive, and effective treatment for SSHL. PMID:26863274

  3. [Aggravation after Diagnosis of Sudden Sensorineural Hearing Loss].

    Science.gov (United States)

    Fukumoto, Ichiro; Nemoto, Toshimitsu; Tsukuda, Tomoko; Koshizuka, Keiichi

    2015-03-01

    Among 95 patients with sudden sensorineural hearing loss who received inpatient treatment at our hospital within the 27-month period between October 2009 and December 2011, those in whom hearing loss was aggravated after diagnosis were compared with a control group. Hearing loss aggravation was defined as a decrease by 10 dB or more in the mean hearing threshold at 5 frequencies from 250 to 4,000 Hz or decrease of 15 dB or more in the hearing threshold at 2 consecutive frequencies. Hearing loss was aggravated after diagnosis in 22 (23.2%) of the 95 patients, showing a similar tendency to that previously reported. Although the grades of hearing loss in these patients were higher than those in 73 control group patients, according to the sudden hearing loss severity classification, their outcomes were favorable. The hearing loss aggravation group consisted of those with steroid-dependent hearing loss (6) and those who had undergone perilymphatic fistula repair (4), in addition to a large number of patients with idiopathic hearing loss, including suspicious perilymphatic fistula (10). When hearing loss becomes aggravated after the diagnosis of sudden sensorineural hearing loss, it may be important to determine the most appropriate approach in each case, such as a careful and gradual decrease in the adenocortical steroid dose and the consideration of perilymphatic fistula repair.

  4. Hyperbaric oxygen therapy for idiopathic sudden sensorineural hearing loss.

    Science.gov (United States)

    Murphy-Lavoie, H; Piper, S; Moon, R E; Legros, T

    2012-01-01

    Idiopathic sudden sensorineural hearing loss (ISSHL) is the newest indication approved by the Undersea and Hyperbaric Medical Society's Hyperbaric Oxygen Therapy Committee. Idiopathic sudden sensorineural hearing loss appears to be characterized by hypoxia in the perilymph and therefore the scala tympani and the organ of Corti. A review of the literature reveals more than 100 publications evaluating the use of hyperbaric oxygen (HBO2) for the treatment of ISSHL, including eight randomized controlled trials. The best and most consistent results are obtained when HBO2 is initiated within two weeks of symptom onset and combined with corticosteroid treatment. The average hearing gain is 19.3 dB for moderate hearing loss and 37.7 dB for severe cases. This improvement brings hearing deficits from the moderate/severe range into the slight/no impairment range. This is a significant gain that can markedly improve a patient's quality of life, both clinically and functionally.

  5. Sudden sensorineural hearing loss after non-otologic surgery.

    Science.gov (United States)

    Page, Joshua Cody; Peters, Bob

    2015-01-01

    Sudden sensorineural hearing loss following non-otologic surgery is a rare event described in the medical literature. Cardiopulmonary bypass surgery is most commonly associated with this type of hearing loss. Our case report and review of the literature describe two cases with postoperative hearing loss - neither of which are cardiac surgeries - making them exceedingly rare in the medical literature. Regardless of the rarity of this unfortunate event, the possibility for permanent hearing loss is a potentially devastating unanticipated complication and one that all surgeons should be aware.

  6. 急性低频感音神经性听力损失的研究进展%Acute low-tone sensorineural hearing loss:research advances

    Institute of Scientific and Technical Information of China (English)

    刘岩; 高云; 王秋菊; 王大勇

    2015-01-01

    Acute low-tone sensorineural hearing loss (ALHL) is a special type of sudden sensorineural hearing loss, which arises growing concern in clinical practice in recent years. Its clinical manifestations are sudden drop of low-frequency hearing without obvious causes, normal hearing of high-frequency area, no vertigo seizures or spontaneous eye shake, and normal auditory brainstem response (ABR). The disease seems to be related to endolymphatic hydrops, topical ischemic injury, immune factors and so on. Glucocorticoid treatment is very effective with good prognosis. Progression and recurrence of ALHL may be associated with Meniere’s disease.%急性低频感音神经性听力损失(ALHL)是近年来逐渐引起临床关注的一种特殊类型的突发性感音神经性耳聋。临床表现为无明显诱因的低频听力突发性下降,高频区听力正常,不伴眩晕发作和自发性眼震,听性脑干反应正常。其发病机制可能与内淋巴积水、局部缺血损伤、免疫等有关。激素治疗对其有效,预后良好。ALHL的病情进展和复发情况可能与梅尼埃病有一定的关联。

  7. Isolated Sensorineural Hearing Loss as a Sequela after Lightning Strike

    Directory of Open Access Journals (Sweden)

    Mahfuz Turan

    2015-01-01

    Full Text Available In most of the surviving patients after a lightning strike, audiovestibular abnormalities have been reported. The most frequently reported type of abnormalities is a tympanic membrane perforation with hearing loss and external ear canal burn. However a sensor neural hearing loss and mixed type hearing loss can also occur, but these occur rarely. A nineteen-year-old female patient had, after a lightning strike, serious burns on the left ear, behind the ear, and on the chest and neck. She also had in her left ear 108 dB hearing loss with irregular central perforation and in her right ear 52 dB sensorineural hearing loss. There was no hearing loss before the strike. A hearing aid was recommended for the right ear and good care and follow-up were recommended for the left ear. A lightning strike can cause serious audiological damage. Therefore, it is necessary to make a careful audiovestibular evaluation of the patients. Although there exist rarely healed cases from sensorineural hearing loss after lightning strike in literature, in our case hearing loss occurred bilaterally and then it healed unilaterally. This condition is quite rare in literature.

  8. Sudden sensorineural hearing loss posthypothyroidism: A case study

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    Priya Karimuddanahally Premkumar

    2016-01-01

    Full Text Available Sudden sensorineural hearing loss is defined as a loss of at least 30 dB in three contiguous frequencies over a period of three days or less. In the present study a client with sudden hearing loss post hypothyroidism is discussed. A 56 year old client reported of awakening from sleep due to ear fullness along with severe tinnitus and experienced reduced hearing sensitivity in the right ear. The client had a history of hypothyroidism and was under medication for the same. The successive audiological investigations revealed that there was no improvement from prescribed medications, even with early identification and intervention. For better treatment outcomes correct identification of the cause as well as application of cause based treatment procedure is essential. Endocrine disorder is said to be one of the causes for sudden sensorineural hearing loss and one among this disorder is hypothyroidism. The present study aimed to throw a light on this aspect by giving a detailed case report of the client who suffered sudden sensorineural hearing loss which is suspected to be a long term effect of hypothyroidism.

  9. Lipid Profile among Patients with Sudden Sensorineural Hearing Loss.

    Science.gov (United States)

    Mohammed, Ali A Muttalib

    2014-12-01

    Associations between hearing and blood lipids have been the focus of scientific inquiry for more than 50 years. The aim of the present study is to evaluate the association between hyperlipidaemia among patients presented with sudden sensorineural hearing loss compared to normal controls. A case control study concerned with 22 patients presented with sudden sensorineural hearing loss who underwent lipid profile evaluation. The lipid profile of these patients was compared with corresponding results of 55 age matched persons (volunteers) with normal hearing. These patients were collected from the Out Patient Department of ENT at Al-Jamhory Teaching Hospital, Mosul/Iraq and private clinic of the author for the period from February 2011 to July 2013. The average age of patients was 44.7 years with a range of 26-65 years. The peak age incidence was in the 5(th) decade of life. The study included 11 male patients (50 %) and 11 females (50 %). Meanwhile, the average age of the control group was 41.7 years with 25 (45.5 %) males and 30 (54.5 %) females. Statistical analysis showed that there was significant difference between the means of lipid profile and blood sugar of the patients and the control group apart from HDL where there was no significant difference. In conclusion, hyperlipidemia seems to be significantly associated with the occurrence of sudden sensorineural hearing loss according to this study.

  10. Head Position Comparison between Students with Normal Hearing and Students with Sensorineural Hearing Loss

    Science.gov (United States)

    Melo, Renato de Souza; Amorim da Silva, Polyanna Waleska; Souza, Robson Arruda; Raposo, Maria Cristina Falcão; Ferraz, Karla Mônica

    2013-01-01

    Introduction Head sense position is coordinated by sensory activity of the vestibular system, located in the inner ear. Children with sensorineural hearing loss may show changes in the vestibular system as a result of injury to the inner ear, which can alter the sense of head position in this population. Aim Analyze the head alignment in students with normal hearing and students with sensorineural hearing loss and compare the data between groups. Methods This prospective cross-sectional study examined the head alignment of 96 students, 48 with normal hearing and 48 with sensorineural hearing loss, aged between 7 and 18 years. The analysis of head alignment occurred through postural assessment performed according to the criteria proposed by Kendall et al. For data analysis we used the chi-square test or Fisher exact test. Results The students with hearing loss had a higher occurrence of changes in the alignment of the head than normally hearing students (p < 0.001). Forward head posture was the type of postural change observed most, occurring in greater proportion in children with hearing loss (p < 0.001), followed by the side slope head posture (p < 0.001). Conclusion Children with sensorineural hearing loss showed more changes in the head posture compared with children with normal hearing. PMID:25992037

  11. Head Position Comparison between Students with Normal Hearing and Students with Sensorineural Hearing Loss

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    Melo, Renato de Souza

    2013-09-01

    Full Text Available Introduction: Head sense position is coordinated by sensory activity of the vestibular system, located in the inner ear. Children with sensorineural hearing loss may show changes in the vestibular system as a result of injury to the inner ear, which can alter the sense of head position in this population. Aim: Analyze the head alignment in students with normal hearing and students with sensorineural hearing loss and compare the data between groups. Methods: This prospective cross-sectional study examined the head alignment of 96 students, 48 with normal hearing and 48 with sensorineural hearing loss, aged between 7 and 18 years. The analysis of head alignment occurred through postural assessment performed according to the criteria proposed by Kendall et al. For data analysis we used the chi-square test or Fisher exact test. Results: The students with hearing loss had a higher occurrence of changes in the alignment of the head than normally hearing students (p < 0.001. Forward head posture was the type of postural change observed most, occurring in greater proportion in children with hearing loss (p < 0.001, followed by the side slope head posture (p < 0.001. Conclusion: Children with sensorineural hearing loss showed more changes in the head posture compared with children with normal hearing.

  12. Sensorineural hearing loss in insulin-dependent diabetic patients

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    Koosha A.

    2007-11-01

    Full Text Available Background: Among patients who have sensorineural hearing loss of unknown etiology, diabetes is one of the diseases to be routinely investigated. The relationship between diabetes mellitus and hearing loss is still controversial. The purpose of this study was to examine the prevalence of sensorineural hearing loss in patients with insulin-dependent diabetes mellitus (IDDM compared to control group.Methods: In a cross-sectional study pure tone audiometry (PTA and speech audiometry was performed in 62 patients with insulin-dependent diabetes mellitus (IDDM, aged under 40 years, and in 62 randomly selected age-matched non-diabetic control subjects. Subjects with otological and other metabolic diseases were excluded from the study. We applied the SPSS.10 statistical analysis software Chi-square and student's test. Results: Statistical analysis showed that the hearing of the diabetic patients were significantly worsen than the control subjects. The hearing level tended to be worsen in the diabetic patients than that in control subjects, but the differences were statistically significant only at frequencies of 250,500, 4000 and 8000 Hz p>0.05(. There wasn't statistical significant difference between sex in two study groups p>0.05(. The mean duration of diabetes was no statistically significant with hearing loss p>0.05(. The frequency of complications such as retinopathy, nephropathy, and neuropathy in the diabetic groups had no correlation with speech threshold (p>0.05(.‏ There were no significant differences between speech reception threshold, speech discrimination score and acoustic reflex in two groups.Conclusions: We conclude that type I diabetes mellitus can cause sensorineural hearing loss.

  13. Sudden onset unilateral sensorineural hearing loss after rabies vaccination.

    Science.gov (United States)

    Okhovat, Saleh; Fox, Richard; Magill, Jennifer; Narula, Antony

    2015-12-15

    A 33-year-old man developed profound sudden onset right-sided hearing loss with tinnitus and vertigo, within 24 h of pretravel rabies vaccination. There was no history of upper respiratory tract infection, systemic illness, ototoxic medication or trauma, and normal otoscopic examination. Pure tone audiograms (PTA) demonstrated right-sided sensorineural hearing loss (thresholds 90-100 dB) and normal left-sided hearing. MRI internal acoustic meatus, viral serology (hepatitis B, C, HIV and cytomegalovirus) and syphilis screen were normal. Positive Epstein-Barr virus IgG, viral capsid IgG and anticochlear antibodies (anti-HSP-70) were noted. Initial treatment involved a course of high-dose oral prednisolone and acyclovir. Repeat PTAs after 12 days of treatment showed a small improvement in hearing thresholds. Salvage intratympanic steroid injections were attempted but failed to improve hearing further. Sudden onset sensorineural hearing loss (SSNHL) is an uncommon but frightening experience for patients. This is the first report of SSNHL following rabies immunisation in an adult.

  14. Hyperbaric oxygen therapy in sudden sensorineural hearing loss following spinal anesthesia: case reports.

    Science.gov (United States)

    Carneiro, Sandra N; Guerreiro, Ditza V; Cunha, Anita M; Camacho, Óscar F; Aguiar, Isabel C

    2016-01-01

    The management of sudden sensorineural hearing loss following spinal anesthesia is currently an open problem. Several strategies have been used with variable results and, to the best of our knowledge, there are no prior accounts in the literature on the use of hyperbaric oxygen therapy in the treatment of this complication. We report two cases of acute onset of unilateral hearing loss after spinal anesthesia, with significantly improved results after hyperbaric oxygen therapy. A hypothesis on the possible mechanism behind this complication is discussed. A relation is established between hyperbaric oxygen therapy and this hypothetical mechanism, in order to explain successful results in the reported cases.

  15. Alternating sudden sensorineural hearing loss in demyelinating disorders

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    Rajeev Gupta

    2016-01-01

    Full Text Available Multiple sclerosis (MS is the most common demyelinating disease of the central nervous system. MS is a neuromotor disorder which progresses with remissions and relapsing periods. Symptoms of MS plaques may regress completely or heal by leaving sequelae. Symptomatology of MS may be very variable. These symptoms usually show variations depending on the localization of demyelinated plaques in the central nervous system. In this case, we are presenting a case of sudden sensorineural hearing loss in alternate ears with magnetic resonance images suggestive of demyelinating disorders. These hearing losses are improved completely as disease has remission and relapsing periods.

  16. Implications of Sensorineural Hearing Loss With Hydrocodone/Acetaminophen Abuse.

    Science.gov (United States)

    Novac, Andrei; Iosif, Anamaria M; Groysman, Regina; Bota, Robert G

    2015-01-01

    Sensorineural hearing loss is an infrequently recognized side effect of pain medication abuse. Chronic pain patients treated with opiates develop different degrees of tolerance to pain medications. In many cases, the tolerance becomes the gateway to a variety of cycles of overuse and unmasking of significant psychiatric morbidity and mortality. An individualized approach utilizing combined treatment modalities (including nonopiate pharmaceuticals) is expected to become the norm. Patients can now be provided with multidisciplinary care that addresses an individual's psychiatric, social, and medical needs, which requires close cooperation between physicians of varying specialties. This report describes a patient who experienced hearing loss from hydrocodone/acetaminophen abuse. PMID:26835162

  17. Resolution of sudden sensorineural hearing loss following a roller coaster ride.

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    Kumar, Aman; Sinha, Amrita; Al-Waa, Ahmad M

    2011-07-01

    We report a case of sudden unilateral sensorineural hearing loss of sudden onset during an aeroplane flight, which completely resolved during a roller coaster ride at Alton Towers theme park. A review of the literature concerning sudden idiopathic sensorineural hearing loss and spontaneous resolution are discussed. Initially, pure-tone audiometry showed a profound sensorineural hearing loss in the right ear and mild sensorineural hearing loss in the left ear (of note, the hearing was normal prior to the episode). Following resolution of the patient's symptoms during a roller coaster ride, pure-tone audiometry showed normal hearing thresholds in both ears. Sudden sensorineural hearing loss is a symptom of cochlear injury and the mechanism of the patient's symptoms was attributed to a patent cochlear aqueduct.

  18. Resolution of sudden sensorineural hearing loss following a roller coaster ride.

    Science.gov (United States)

    Kumar, Aman; Sinha, Amrita; Al-Waa, Ahmad M

    2011-07-01

    We report a case of sudden unilateral sensorineural hearing loss of sudden onset during an aeroplane flight, which completely resolved during a roller coaster ride at Alton Towers theme park. A review of the literature concerning sudden idiopathic sensorineural hearing loss and spontaneous resolution are discussed. Initially, pure-tone audiometry showed a profound sensorineural hearing loss in the right ear and mild sensorineural hearing loss in the left ear (of note, the hearing was normal prior to the episode). Following resolution of the patient's symptoms during a roller coaster ride, pure-tone audiometry showed normal hearing thresholds in both ears. Sudden sensorineural hearing loss is a symptom of cochlear injury and the mechanism of the patient's symptoms was attributed to a patent cochlear aqueduct. PMID:22754856

  19. Risk of sudden sensorineural hearing loss in patients with common preexisting sensorineural hearing impairment: a population-based study in Taiwan.

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    Malcolm Koo

    Full Text Available The role of preexisting sensorineural hearing impairment on the risk for sudden sensorineural hearing loss (SSHL is still unclear. In this study, we aimed to assess the risk of SSHL in patients with common preexisting sensorineural hearing impairment using population-based data.A population-based case-control study design was used to analyze claims data between January 2001 and December 2011 obtained from the Taiwan National Health Insurance Research Database. The cases consisted of 514 patients with SSHL and the controls were frequency matched to 2,570 cases by sex, 10-year age group, and year of index date. Common sensorineural hearing impairments were retrospectively assessed in the cases and controls. Associations between sensorineural hearing impairment and risk of SSHL were evaluated using unconditional univariate and multivariate logistic regression analyses.The mean age for the 3,084 study subjects was 53.1 years (standard deviation, S.D. = 15.6. Of the 514 cases, 49 (9.5% had sensorineural hearing impairment while only 44 (1.7% of the 2,570 controls had the same condition. Univariate logistic regression analyses indicated that preexisting sensorineural hearing impairment was significantly associated with SSHL (odds ratio, OR = 6.05, p < 0.001. Other comorbidities including hypertension, diabetes mellitus, and hyperlipidemia also showed significant associations with SSHL. Similar results were obtained when the association between SSHL and sensorineural hearing impairment was adjusted with either all the covariates (adjusted OR = 6.22, p < 0.001 or with only those selected using a backward elimination procedure (adjusted OR = 6.20, p < 0.001.Results from this population-based case-control study revealed that common sensorineural hearing impairment might be a novel risk factor for SSHL.

  20. Risk of Sudden Sensorineural Hearing Loss in Patients with Common Preexisting Sensorineural Hearing Impairment: A Population-Based Study in Taiwan

    Science.gov (United States)

    Koo, Malcolm; Hwang, Juen-Haur

    2015-01-01

    Objective The role of preexisting sensorineural hearing impairment on the risk for sudden sensorineural hearing loss (SSHL) is still unclear. In this study, we aimed to assess the risk of SSHL in patients with common preexisting sensorineural hearing impairment using population-based data. Methods A population-based case-control study design was used to analyze claims data between January 2001 and December 2011 obtained from the Taiwan National Health Insurance Research Database. The cases consisted of 514 patients with SSHL and the controls were frequency matched to 2,570 cases by sex, 10-year age group, and year of index date. Common sensorineural hearing impairments were retrospectively assessed in the cases and controls. Associations between sensorineural hearing impairment and risk of SSHL were evaluated using unconditional univariate and multivariate logistic regression analyses. Results The mean age for the 3,084 study subjects was 53.1 years (standard deviation, S.D. = 15.6). Of the 514 cases, 49 (9.5%) had sensorineural hearing impairment while only 44 (1.7%) of the 2,570 controls had the same condition. Univariate logistic regression analyses indicated that preexisting sensorineural hearing impairment was significantly associated with SSHL (odds ratio, OR = 6.05, p < 0.001). Other comorbidities including hypertension, diabetes mellitus, and hyperlipidemia also showed significant associations with SSHL. Similar results were obtained when the association between SSHL and sensorineural hearing impairment was adjusted with either all the covariates (adjusted OR = 6.22, p < 0.001) or with only those selected using a backward elimination procedure (adjusted OR = 6.20, p < 0.001). Conclusions Results from this population-based case-control study revealed that common sensorineural hearing impairment might be a novel risk factor for SSHL. PMID:25815507

  1. Sensorineural deafness

    Science.gov (United States)

    Nerve deafness; Hearing loss - sensorineural; Acquired hearing loss; SNHL; Noise-induced hearing loss; NIHL; Presbycusis ... that carries the signals to the brain. Sensorineural deafness that is present at birth (congenital) is most ...

  2. Vestibular evoked myogenic potential in sudden sensorineural hearing loss

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    Feroze Kancharu Khan

    2013-01-01

    Full Text Available Aim and Objective: To investigate saccular damage in patients with sudden sensorineural hearing loss (SSNHL with or without vertigo and to evaluate the saccular damage according to the hearing loss and presence or absence of vertigo. Materials and Methods: All tests done in this study were performed in the audio vestibular unit of ENT department from September 2009 to November 2010. Statistical Analysis Used: The association between the severity of hearing loss and changes in the vestibular evoked myogenic potential (VEMP recordings were assessed using descriptive statistics. The pattern of VEMP in different diseases and also the behavior of VEMP in presence or absence of vertigo were evaluated using SPSS 15. Results: Among 27 patients there were 11 cases of idiopathic SSNHL. Out of nine unaffected ears, 88% had normal and 12% had absent VEMP. Whereas out of 13 affected ears, only 53.9% had normal VEMP. Among all the 54 ears, 17 ears had normal hearing. In this group 76.47% had normal VEMP. The group with hearing loss > 90 dB had 61.53% absent VEMP. Conclusions: In patients with unilateral SSNHL, there was a tendency for the affected ear to have absent VEMP indicating the saccular involvement. The extent of saccular damage did not correspond to the amount of hearing loss or presence or absence of vertigo.

  3. MANAGEMENT OF IDIOPATHIC SUDDEN SENSORINEURAL HEARING LOSS: OUR EXPERIENCE

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    Surya Prakash

    2015-12-01

    Full Text Available Sudden Sensorineural Hearing Loss (SSHL is dreaded condition affecting many individuals around the world due to its sudden appearance and inconspicuous nature of disease. More than 50% recover spontaneously, but timely identification of cause and treatment can help the patient immensely. METHODS In our study, we prospectively analyzed twenty patients presenting with idiopathic sudden hearing loss of 30 db or more between 2010 and 2015. RESULTS Two out of 20 patients (60% showed complete improvement and 10 patients out of 13 (77% who presented with 7 days showed complete recovery. Hence, time of presentation and drugs used directly affect the outcome of the patient. CONCLUSION It can be safely concluded that early diagnosis and management is key in treatment of SSHL. Intratympanic dexamethasone with intravenous dexamethasone or oral deflazacort is used in all patients with supportive measures has helped most of our patients. Oral acyclovir was used in only one patient.

  4. Endothelial Dysfunction in Idiopathic Sudden Sensorineural Hearing Loss: A Review.

    Science.gov (United States)

    Quaranta, Nicola; De Ceglie, Vincenzo; D'Elia, Alessandra

    2016-04-20

    An endothelial dysfunction has been described in idiopathic sudden sensorineural hearing loss (ISSHL) patients. The purpose of our review was to: i) identify, evaluate and review recent research about cardiovascular risk factors involvement and signs of endothelial dysfunction in ISSHL; ii) implication of these discovering in clinical practice and future research. A Medline literature search was conducted to identify any study on the involvement of endothelial dysfunction in ISSHL, published in the English language in the last decade. The following MEDLINE search terms were used: sudden sensorineural hearing loss (SSHL) and endothelial dysfunction (text words). Additional studies were identified by hand searching the references of original articles and review articles. Studies were not excluded on the basis of the qualitative or quantitative definitions of SSHL, treatment regimens, or outcome measures. Data were extracted from included papers by a reviewer. Information on the patients, investigations, methods, interventions, and outcomes were systematically analyzed. Characteristics and results of all included studies were reviewed systematically. High levels of adhesion molecules, hyperhomocysteinemia and lower folate levels, unbalanced oxidative status, a lower value of flow-mediated dilatation of brachial artery and a reduced percentage of circulating endothelial progenitor cells in patients affected by ISSHL support the hypothesis that this syndrome should be considered as a microcirculation disorder based on endothelial dysfunction and drive clinicians to implement all the traditional strategies used for preventing cardiovascular events, to also reduce the likelihood of ISSHL occurrence. PMID:27588164

  5. Endothelial dysfunction in idiopathic sudden sensorineural hearing loss: a review

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    Nicola Quaranta

    2016-07-01

    Full Text Available An endothelial dysfunction has been described in idiopathic sudden sensorineural hearing loss (ISSHL patients. The purpose of our review was to: i identify, evaluate and review recent research about cardiovascular risk factors involvement and signs of endothelial dysfunction in ISSHL; ii implication of these discovering in clinical practice and future research. A Medline literature search was conducted to identify any study on the involvement of endothelial dysfunction in ISSHL, published in the English language in the last decade. The following MEDLINE search terms were used: sudden sensorineural hearing loss (SSHL and endothelial dysfunction (text words. Additional studies were identified by hand searching the references of original articles and review articles. Studies were not excluded on the basis of the qualitative or quantitative definitions of SSHL, treatment regimens, or outcome measures. Data were extracted from included papers by a reviewer. Information on the patients, investigations, methods, interventions, and outcomes were systematically analyzed. Characteristics and results of all included studies were reviewed systematically. High levels of adhesion molecules, hyperhomocysteinemia and lower folate levels, unbalanced oxidative status, a lower value of flow-mediated dilatation of brachial artery and a reduced percentage of circulating endothelial progenitor cells in patients affected by ISSHL support the hypothesis that this syndrome should be considered as a microcirculation disorder based on endothelial dysfunction and drive clinicians to implement all the traditional strategies used for preventing cardiovascular events, to also reduce the likelihood of ISSHL occurrence.

  6. Endothelial Dysfunction in Idiopathic Sudden Sensorineural Hearing Loss: A Review.

    Science.gov (United States)

    Quaranta, Nicola; De Ceglie, Vincenzo; D'Elia, Alessandra

    2016-04-20

    An endothelial dysfunction has been described in idiopathic sudden sensorineural hearing loss (ISSHL) patients. The purpose of our review was to: i) identify, evaluate and review recent research about cardiovascular risk factors involvement and signs of endothelial dysfunction in ISSHL; ii) implication of these discovering in clinical practice and future research. A Medline literature search was conducted to identify any study on the involvement of endothelial dysfunction in ISSHL, published in the English language in the last decade. The following MEDLINE search terms were used: sudden sensorineural hearing loss (SSHL) and endothelial dysfunction (text words). Additional studies were identified by hand searching the references of original articles and review articles. Studies were not excluded on the basis of the qualitative or quantitative definitions of SSHL, treatment regimens, or outcome measures. Data were extracted from included papers by a reviewer. Information on the patients, investigations, methods, interventions, and outcomes were systematically analyzed. Characteristics and results of all included studies were reviewed systematically. High levels of adhesion molecules, hyperhomocysteinemia and lower folate levels, unbalanced oxidative status, a lower value of flow-mediated dilatation of brachial artery and a reduced percentage of circulating endothelial progenitor cells in patients affected by ISSHL support the hypothesis that this syndrome should be considered as a microcirculation disorder based on endothelial dysfunction and drive clinicians to implement all the traditional strategies used for preventing cardiovascular events, to also reduce the likelihood of ISSHL occurrence.

  7. Glucocorticoid influence on prognosis of idiopathic sudden sensorineural hearing loss

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    Eduardo Amaro Bogaz

    2014-06-01

    Full Text Available INTRODUCTION: Idiopathic Sudden Sensorineural Hearing Loss (ISSHL is defined when a loss of at least 30 dB occurs in over 3 continuous frequencies, in up to 72 hours, of which etiology is not established, despite adequate investigation. Different types of treatment regimens have been proposed, but only glucocorticoids have shown some evidence of benefit in the literature. OBJECTIVE: To analyze whether the type of treatment or time of treatment with glucocorticoids have any influence on hearing recovery in ISSHL. METHODS: Observational retrospective cohort study. One hundred twenty-seven patients with ISSHL, treated at outpatient clinics between the years 2000 and 2010, were studied. We evaluated the prognostic correlation of the type of treatment and time to treatment with glucocorticoids and ISSHL. RESULTS: The absolute hearing gain and the relative hearing gain was as follows: 23.6 dB and 37.2%. Complete recovery was observed in 15.7% of patients, significant recovery in 27.6% and recovery in 57.5%. CONCLUSION: In this study, there was no difference between the use and nonuse of glucocorticoids in hearing improvement. However, when started within seven days after onset, the use of glucocorticoids was a factor of better prognosis.

  8. Clinical Study on 136 Children with Sudden Sensorineural Hearing Loss

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    Li, Feng-Jiao; Wang, Da-Yong; Wang, Hong-Yang; Wang, Li; Yang, Feng-Bo; Lan, Lan; Guan, Jing; Yin, Zi-Fang; Rosenhall, Ulf; Yu, Lan; Hellstrom, Sten; Xue, Xi-Jun; Duan, Mao-Li; Wang, Qiu-Ju

    2016-01-01

    Background: The prevalence of sudden sensorineural hearing loss in children (CSSNHL) is consistently increasing. However, the pathology and prognosis of CSSNHL are still poorly understood. This retrospective study evaluated clinical characteristics and possible associated factors of CSSNHL. Methods: One hundred and thirty-six CSSNHL patients treated in Department of Otolaryngology-Head and Neck Surgery and Institute of Otolaryngology at Chinese PLA General Hospital between July 2008 and August 2015 were included in this study. These patients were analyzed for clinical characteristics, audiological characteristics, laboratory examinations, and prognostic factors. Results: Among the 136 patients (151 ears), 121 patients (121 ears, 80.1%) were diagnosed with unilaterally CSSNHL, and 15 patients (30 ears, 19.9%) with bilateral CSSNHL. The complete recovery rate of CSSNHL was 9.3%, and the overall recovery rate was 37.7%. We found that initial degree of hearing loss, onset of treatment, tinnitus, the ascending type audiogram, gender, side of hearing loss, the recorded auditory brainstem response (ABR), and distortion product otoacoustic emissions (DPOAEs) had prognostic significance. Age, ear fullness, and vertigo had no significant correlation with recovery. Furthermore, the relevant blood tests showed 30.8% of the children had abnormal white blood cell (WBC) counts, 22.1% had elevated homocysteine levels, 65.8% had high alkaline phosphatase (ALP), 33.8% had high IgE antibody levels, and 86.1% had positive cytomegalovirus (CMV) IgG antibodies. Conclusions: CSSNHL commonly occurs unilaterally and results in severe hearing loss. Initial severe hearing loss and bilateral hearing loss are negative prognostic factors for hearing recovery, while positive prognostic factors include tinnitus, gender, the ascending type audiogram, early treatment, identifiable ABR waves, and DPOAEs. Age, vertigo, and ear fullness are not correlated with the recovery. Some serologic indicators

  9. Otolithic organ function in patients with profound sensorineural hearing loss

    Institute of Scientific and Technical Information of China (English)

    Yujuan Zhou; Yongzhen Wu; Jing Wang

    2016-01-01

    Profound sensorineural hearing loss (PSHL) is not uncommonly encountered in otology. In clinics, there is a high incidence of otolithic damage in patients with PSHL, but relevant reports are few. Sharing a continuous membranous structure and similar receptor cell ultrastructures, the cochlea and vestibule may be susceptible to the same harmful factors. Disorders of the inner ear may result in a variety of manifestations, including vertigo, spatial disorientation, blurred vision, impaired articulation, and hearing impairment. Considering the diversity of clinical symptoms associated with PSHL with otolithic dysfunction, it may be frequently misdiagnosed, and objective means of testing the function of otolithic organs should be recommended for hearing-impaired patients. Vestibular-evoked myogenic potentials (VEMPs) via air-conducted sound are of great importance for the diagnosis of otolithic function. Hearing devices such as cochlear implants are commonly accepted treatments for PSHL, and early identification and treatment of vestibular disorders may increase the success rate of cochlear implantation. Therefore, it is necessary to increase awareness of otolithic functional states in patients with PSHL.

  10. Characteristics and Spontaneous Recovery of Tinnitus Related to Idiopathic Sudden Sensorineural Hearing Loss

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    Mühlmeier, Guido; Baguley, David; Cox, Tony; Suckfüll, Markus; Meyer, Thomas

    2016-01-01

    Objective: To evaluate the characteristics and spontaneous recovery of tinnitus related to idiopathic sudden sensorineural hearing loss (ISSNHL). Study Design: Retrospective analysis from two randomized placebo-controlled clinical trials for treatment of ISSNHL within 48 hours from onset (Study A), or of tinnitus related to ISSNHL within 3 months from onset (Study B). Setting: Forty-eight European sites (academic tertiary referral centers, private ENT practices). Patients: One hundred thirteen adult patients of which 65 with hearing loss ≥30 dB (Study A) and 48 with persistent acute tinnitus (Study B) at baseline. Interventions: Intratympanic (i.t.) injection of placebo gel in single dose or in triple dose during 3 consecutive days. Main Outcome Measures: Frequency of tinnitus, subjective tinnitus loudness, rates of complete tinnitus remission, and complete hearing recovery during 3 months follow-up. Results: In acute ISSNHL, tinnitus loudness decreased rapidly in cases of mild-moderate hearing loss, and tinnitus had completely resolved in two-thirds of patients after 3 months. Hearing recovery preceded tinnitus resolution. When associated with severe-profound hearing loss, tinnitus improved significantly less. Complete hearing recovery and full tinnitus remission were both about three times more frequent in mild-moderate hearing loss patients than in severe-profound cases. Improvement in tinnitus loudness over time can be approximated by a negative exponential function. Conclusions: Prognosis for ISSNHL-related tinnitus is relatively poor in case of severe-profound hearing loss and the longer it has persisted. Alleviation or management of tinnitus should be a key therapeutic objective especially in pronounced ISSNHL cases. PMID:27228021

  11. Strategies for developing novel therapeutics for sensorineural hearing loss

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    Takayuki eNakagawa

    2014-09-01

    Full Text Available Sensorineural hearing loss (SNHL is a common disability in the world; however, at present, options for the pharmacological treatment of SNHL are very limited. Previous studies involving human temporal bone analyses have revealed that the degeneration of the cochlea is a common mechanism of SNHL. A major problem for the development of novel pharmacotherapy for SNHL has been the limited regeneration capacity in mammalian cochlear cells. However, recent progress in basic studies has led to several effective strategies for the induction of regeneration in the mammalian cochlea, in accordance with the stage of degeneration. In addition, recent advances in the identification of human deafness genes and their characterization in mouse models have elucidated cellular and/or molecular mechanisms of SNHL, which will contribute to clarify molecular targets of pharmacotherapy for treatment of SNHL.

  12. Factors influencing the outcome of idiopathic sudden sensorineural hearing loss treated with hyperbaric oxygen therapy.

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    Körpinar, Sefika; Alkan, Zeynep; Yiğit, Ozgür; Gör, Ayşe Pelin; Toklu, Akin Savaş; Cakir, Burak; Soyuyüce, Ozlem Gedik; Ozkul, Haluk

    2011-01-01

    Idiopathic sudden sensorineural hearing loss (ISSNHL) is an otologic emergency with an incidence of about 5-20 per 100,000 of the population per year. There is no universally accepted standard protocol for the treatment of patients with ISSNHL. Hyperbaric oxygen therapy (HBOT), was first reported to improve the outcome following acute inner ear disorders during the late 1960s by both French and German authors. The increase in perilymph oxygenation produced by HBOT provides logical basis for the use of this treatment modality in ISSNHL. We reviewed the records of 97 cases that received HBOT for SSNHL to identify the factors that may affect the treatment outcomes. The effects of age, gender, affected ear, status of the contralateral ear, symptoms associated with hearing loss, presence of a cardiovascular disease, dyslipidemia, history of diabetes mellitus, seasonal factor, smoking, degree of hearing loss, audiogram type, medical treatments provided prior to HBOT, onset time, and number of HBOT sessions were evaluated. The mean hearing gain in all cases after the HBOT was 29.5 dB. The gains were statistically significant in the following cases: early onset of HBOT (p = 0.016), higher number of HBOT sessions (p hearing loss (p = 0.011). The success rate was significantly lower in cases with high frequency-descending audiogram configuration (p hearing loss.

  13. Reversible Sensorineural Hearing Loss in Celiac Disease: Is it A Coincidental Finding?

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    Kenan Çelik

    2013-12-01

    Full Text Available Celiac Disease (CD is an autoimmune disease of the small intestine characterized by the immune response against ingested gluten. This response causes characteristic damage to the villi, which in turn results in malabsorption. Clinical signs and symptoms of CD may start early in childhood or in adulthood. Some people are completely asymptomatic. The term celiac crisis is used for patients with acute-onset severe abdominal pain which is potentially fatal. Although various extraintestinal signs and symptoms have been defined in CD, there are contradictory reports regarding hearing loss. We hereby report a patient with celiac disease who was investigated for malabsorption and was diagnosed with mild to medium temporary sudden sensorineural hearing loss (SNHL. (The Medical Bulletin of Haseki 2013;51:190-2

  14. Sudden post-traumatic sensorineural hearing loss reverted to normal by sneezing

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    Alper Yenigun

    2014-12-01

    Full Text Available An 11-year-old child with sudden post-traumatic sensorineural hearing loss regained his hearing functions after sneezing. This case report is a first in medical literature in describing recovery from hearing loss by sneezing. The therapeutic implications of this rare case deserve further investigation.

  15. Clinical Study on 136 Children with Sudden Sensorineural Hearing Loss

    Institute of Scientific and Technical Information of China (English)

    Feng-Jiao Li; Da-Yong Wang; Hong-Yang Wang; Li Wang; Feng-Bo Yang; Lan Lan; Jing Guan

    2016-01-01

    Background:The prevalence of sudden sensorineural hearing loss in children (CSSNHL) is consistently increasing.However,the pathology and prognosis of CSSNHL are still poorly understood.This retrospective study evaluated clinical characteristics and possible associated factors of CSSNHL.Methods:One hundred and thirty-six CSSNHL patients treated in Department of Otolaryngology-Head and Neck Surgery and Institute of Otolaryngology at Chinese PLA General Hospital between July 2008 and August 2015 were included in this study.These patients were analyzed for clinical characteristics,audiological characteristics,laboratory examinations,and prognostic factors.Results:Among the 136 patients (151 ears),121 patients (121 ears,80.1%) were diagnosed with unilaterally CSSNHL,and 15 patients (30 ears,19.9%) with bilateral CSSNHL.The complete recovery rate of CSSNHL was 9.3%,and the overall recovery rate was 37.7%.We found that initial degree of hearing loss,onset of treatment,tinnitus,the ascending type audiogram,gender,side of hearing loss,the recorded auditory brainstem response (ABR),and distortion product otoacoustic emissions (DPOAEs) had prognostic significance.Age,ear fullness,and vertigo had no significant correlation with recovery.Furthermore,the relevant blood tests showed 30.8% of the children had abnormal white blood cell (WBC) counts,22.1% had elevated homocysteine levels,65.8% had high alkaline phosphatase (ALP),33.8% had high IgE antibody levels,and 86.1% had positive cytomegalovirus (CMV) IgG antibodies.Conclusions:CSSNHL commonly occurs unilaterally and results in severe hearing loss.Initial severe hearing loss and bilateral hearing loss are negative prognostic factors for hearing recovery,while positive prognostic factors include tinnitus,gender,the ascending type audiogram,early treatment,identifiable ABR waves,and DPOAEs.Age,vertigo,and ear fullness are not correlated with the recovery.Some serologic indicators,including the level of WBC

  16. Vestibular schwannoma in patients with sudden sensorineural hearing loss.

    Science.gov (United States)

    Lee, Jong Dae; Lee, Byung Don; Hwang, Sun Chul

    2011-03-01

    Sudden sensorineural hearing loss (SSNHL) has several etiologies. It may be a presenting symptom of vestibular schwannoma (VS). This study aimed to establish the incidence of VS in patients with SSNHL, and we report several unusual cases among these patients. We reviewed retrospectively the charts and magnetic resonance imaging (MRI) findings of all adult patients who presented with SSNHL between 2002 and 2008. We utilized three-dimensional fast imaging with steady-state acquisition temporal MRI as a screening method. Of the 295 patients with SSNHL, VS was found in 12 (4%). All patients had intrameatal or small to medium-sized tumors. There were three cases with SSNHL in one ear and an incidental finding of intracanalicular VS in the contralateral ear. There were four cases of VS that showed good recovery from SSNHL with corticosteroid treatment. There were two cases that mimicked labyrinthitis with hearing loss and vertigo. A greater number of cases than expected of VS were detected in patients with SSNHL, as a result of increasing widespread use of MRI. Various unusual findings in these patients were identified. MRI would seem to be mandatory in all cases of SSNHL.

  17. Classification and hearing evolution of patients with sudden sensorineural hearing loss

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    N.O. Penido

    2009-08-01

    Full Text Available The aim of this study was to analyze clinical aspects, hearing evolution and efficacy of clinical treatment of patients with sudden sensorineural hearing loss (SSNHL. This was a prospective clinical study of 136 consecutive patients with SSNHL divided into three groups after diagnostic evaluation: patients with defined etiology (DE, N = 13, 10%, concurrent diseases (CD, N = 63, 46.04% and idiopathic sudden sensorineural hearing loss (ISSHL, N = 60, 43.9%. Initial treatment consisted of prednisone and pentoxifylline. Clinical aspects and hearing evolution for up to 6 months were evaluated. Group CD comprised 73% of patients with metabolic decompensation in the initial evaluation and was significantly older (53.80 years than groups DE (41.93 years and ISSHL (39.13 years. Comparison of the mean initial and final hearing loss of the three groups revealed a significant hearing improvement for group CD (P = 0.001 and group ISSHL (P = 0.001. Group DE did not present a significant difference in thresholds. The clinical classification for SSNHL allows the identification of significant differences regarding age, initial and final hearing impairment and likelihood of response to therapy. Elevated age and presence of coexisting disease were associated with a greater initial hearing impact and poorer hearing recovery after 6 months. Patients with defined etiology presented a much more limited response to therapy. The occurrence of decompensated metabolic and cardiovascular diseases and the possibility of first manifestation of auto-immune disease and cerebello-pontine angle tumors justify an adequate protocol for investigation of SSNHL.

  18. A case of sudden unilateral sensorineural hearing loss with contralateral psychogenic hearing loss induced by gunshot noise.

    Science.gov (United States)

    Hong, Young-Ho; Mun, Seog-Kyun

    2011-10-01

    The reasons behind sudden sensorineural hearing loss are mostly unknown, but viral infections, blood disorders, ototoxicity, noise trauma, autoimmune disease, acoustic tumor, and even mental stress may be related to the disease. In cases of hearing loss as a result of psychogenic factors, early diagnosis and adequate treatment under collaboration with the psychiatric department are crucial, since failure to take appropriate measures may result in permanent sequela. We report a case, with a review of the literature, of sudden unilateral sensorineural hearing loss with contralateral psychogenic hearing loss induced by gunshot noise.

  19. STUDY OF HEARING OUTCOMES IN SUDDEN SENSORINEURAL HEARING LOSS TREATED WITH TISSUE PLASMINOGEN ACTIVATOR (TPA

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    Rama Krishna

    2015-09-01

    Full Text Available Sudden Sensorineural Hearing Loss (SSHNL is a clinical condition that requires immediate management. There are many treatment options, which may not always revert the hearing to normal. Not only recording the degree of hearing loss, but also establishing the concurrent dysfunction of saccule by VEMP has facilitated a new approach to treatment strategy. Recombinant tissue Plasminogen Activator ((rtPA proved its efficacy in stroke and subsequently considered an option in the management of ISSNHL. The curren t study, conducted at different centres, on 15 patients utilized rtPA. The results showed a promising trend when saccular pathology is also evident by VEMP in association with Hearing loss. We recommend use of rtPA as primary modality in cases of ISSNHL wi th Saccular involvement.

  20. Bilateral sudden sensorineural hearing loss as a presenting feature of systemic lupus erythematosus

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    Chawki, Sylvain; Aouizerate, Jessie; Trad, Selim; Prinseau, Jacques; Hanslik, Thomas

    2016-01-01

    Abstract Introduction: Sudden sensorineural hearing loss is an unusual presenting clinical feature of systemic lupus erythematosus. Case report: We report the case of a young woman who was admitted to hospital for sudden sensorineural hearing loss and hemophagocytic syndrome which was attributed to systemic lupus erythematosus on the basis of specific renal involvement, thrombocytopenia, and consistent autoantibodies. Favorable outcome was obtained on high-dose corticosteroids, and the hearing fully recovered. Discussion: Sudden sensorineural hearing loss in systemic lupus erythematosus is seemingly more frequently associated with severe systemic involvement and antiphospholipid antibodies may be present. Although management remains empirical, the high risk of permanent hearing impairment seems to justify emergency treatment with high-dose corticosteroids. When the clinical and laboratory criteria of antiphospholipid syndrome are met, antiplatelets agents or anticoagulation therapy shall be considered. PMID:27603334

  1. Relative Contributions of Spectral and Temporal Cues for Speech Recognition in Patients with Sensorineural Hearing Loss

    Institute of Scientific and Technical Information of China (English)

    XU Li; ZHOU Ning; Rebecca Brashears; Katherine Rife

    2008-01-01

    The present study was designed to examine speech recognition in patients with sensorineural hearing loss when the temporal and spectral information in the speech signals were co-varied. Four subjects with mild to moderate sensorineural hearing loss were recruited to participate in consonant and vowel recognition tests that used speech stimuli processed through a noise-excited voeoder. The number of channels was varied between 2 and 32, which defined spectral information. The lowpass cutoff frequency of the temporal envelope extractor was varied from 1 to 512 Hz, which defined temporal information. Results indicate that performance of subjects with sensorineural heating loss varied tremendously among the subjects. For consonant recognition, patterns of relative contributions of spectral and temporal information were similar to those in normal-hearing subjects. The utility of temporal envelope information appeared to be normal in the hearing-impaired listeners. For vowel recognition, which depended predominately on spectral information, the performance plateau was achieved with numbers of channels as high as 16-24, much higher than expected, given that the frequency selectivity in patients with sensorineural hearing loss might be compromised. In order to understand the mechanisms on how hearing-impaired listeners utilize spectral and temporal cues for speech recognition, future studies that involve a large sample of patients with sensorineural hearing loss will be necessary to elucidate the relationship between frequency selectivity as well as central processing capability and speech recognition performance using vocoded signals.

  2. The significance of routine laboratory parameters in patients with sudden sensorineural hearing loss.

    Science.gov (United States)

    Yasan, Hasan; Tüz, Mustafa; Yariktaş, Murat; Aynali, Giray; Tomruk, Onder; Akkuş, Omer

    2013-12-01

    There are several factors (viral infections, metabolic and ototoxic disorders etc.) accused for the development of sudden sensorineural hearing loss. Some prognostic factors (late onset of treatment etc.) had been evaluated in the literature. There is no sufficient data on the effect of routine laboratory parameters on the development and/or prognosis of sudden sensorineural hearing loss. The aim of this study is to investigate the effects of routine blood chemistry and hematological parameters on the development and prognosis of disease in patients with idiopathic sudden sensorineural hearing loss. One hundred and forty-seven patients with the diagnosis of idiopathic sudden sensorineural hearing loss followed up during the periods of 2000-2010 years were included in this study. One hundred and three septoplasty patients with no otologic complaints were enrolled as control group. Following the clinical and demographic evaluations, patients with idiopathic sudden sensorineural hearing loss and control groups, and patients treated successfully and patients with poor outcome were compared with each other. Data were analyzed by T test. All hematological and biochemical parameters were compared. Hemoglobin, hematocrit, white blood cell count, total and direct bilirubin, fasting blood glucose level and aspartate aminotransferase were significantly different between idiopathic sudden sensorineural hearing loss and control groups. There was no significantly different parameter between patients treated successfully and patients with poor outcome. Hemoglobin, hematocrit, white blood cell count, total and direct bilirubin, fasting blood glucose level and AST all can be risk factors for SHL, or they can be the result of undetermined pathology, because these parameters have no effect on the prognosis. Other routine parameters seem to have no effect on the development and/or prognosis of idiopathic sudden sensorineural hearing loss.

  3. Gentamicin Exposure and Sensorineural Hearing Loss in Preterm Infants.

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    Aline Fuchs

    Full Text Available To evaluate the impact of gentamicin exposure on sensorineural hearing loss (SNHL in very low birth weight (VLBW infants.Exposure to gentamicin was determined in infants born between 1993 and 2010 at a gestational age < 32 weeks and/or with a birthweight < 1500 g, who presented with SNHL during the first 5 years of life. For each case, we selected two controls matched for gender, gestational age, birthweight, and year of birth.We identified 25 infants affected by SNHL, leading to an incidence of SNHL of 1.58% in our population of VLBW infants. The proportion of infants treated with gentamicin was 76% in the study group and 70% in controls (p = 0.78. The total cumulated dose of gentamicin administered did not differ between the study group (median 10.2 mg/kg, Q1-Q3 1.6-13.2 and the control group (median 7.9 mg/kg, Q1-Q3 0-12.8, p = 0.47. The median duration of gentamicin treatment was 3 days both in the study group and the control group (p = 0.58. Maximum predicted trough serum levels of gentamicin, cumulative area under the curve and gentamicin clearance were not different between cases and controls.The impact of gentamicin on SNHL can be minimized with treatments of short duration, monitoring of blood levels and dose adjustment.

  4. Clinical Features and Prognosis of Sudden Sensorineural Hearing Loss Secondary to Intralabyrinthine Hemorrhage

    Science.gov (United States)

    Lee, Jae Woo; Park, Yoon Ah; Park, Sang Man; Kong, Tae Hoon; Park, Sang Yoo; Bong, Jeong Pyo; Park, Dong-Joon

    2016-01-01

    Background and Objectives A number of etiologies of idiopathic sudden sensorineural hearing loss (ISSNHL) have been proposed, including viral infection, vascular disturbance, and immune-mediated mechanisms. Intralabyrinthine hemorrhage (ILH) as a cause of SSNHL is extremely rare, and there have been no studies defining the characteristics of hearing impairment and prognosis in patients with ISSNHL due to ILH. This study aimed to investigate the difference in impaired hearing patterns and prognosis for hearing recovery between patients with ISSNHL due to ILH confirmed by magnetic resonance imaging (MRI) and sex- and age-matched patients with ISSNHL due to causes other than ILH. Subjects and Methods We compared the results of audiometry and MRI in 12 patients who had ILH on MRI (hemorrhage group) and in 23 sex- and age-matched controls without abnormal findings related to their hearing loss on MRI (non-hemorrhage group). Initial hearing impairment, progression, and recovery of hearing loss were compared between the two groups. Results A majority of patients (92%) in the hemorrhage group complained of dizziness. Initial hearing impairment was more frequent in the hemorrhage group than in the non-hemorrhage group (94.09±35.9 vs. 66.66±30.1, p-value=0.036). The final recovery threshold in the hemorrhage group was worse (78.19±46.26 vs. 37.17±31.96, p-value=0.014) than that in the non-hemorrhage group. In the hemorrhage group, hearing recovery seemed to occur less often at high frequencies (2,000, 4,000, and 8,000 Hz) than at low frequencies (250, 500, and 1,000 Hz). Conclusions The presence of ILH was associated with poor hearing prognosis and the occurrence of vertigo. The abrupt onset of hearing loss associated with vertigo and the presence of hyperresonance on fat-suppressed T1-weighted MRI images of labyrinthic fluid strongly suggests acute intralabyrinthine hemorrhage, and is predictive of considerable hearing impairment and poor prognosis. PMID:27144231

  5. Persistent Positional Vertigo in a Patient with Sudden Sensorineural Hearing Loss: A Case Report.

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    Kim, Yong Won; Shin, Jung Eun; Lee, Yong-Sik; Kim, Chang-Hee

    2015-09-01

    Because inner ear organs are interconnected through the endolymph and surrounding endolymphatic membrane, the patients with sudden sensorineural hearing loss (SSNHL) often complain of vertigo. In this study, we report a patient with SSNHL accompanied by persistent positional vertigo, and serial findings of head-roll tests are described. At acute stage, head-roll test showed persistent geotropic direction-changing positional nystagmus (DCPN), which led to a diagnosis of SSNHL and ipsilateral light cupula. Although vertigo symptom gradually improved, positional vertigo lasted for more than 3 weeks. At this chronic stage, persistent apogeotropic DCPN was observed in a head roll test, which led to a diagnosis of the heavy cupula. Although the mechanism for the conversion of nystagmus direction from geotropic to apogeotropic persistent DCPN is unclear, the change of specific gravity of the endolymph might be one of the plausible hypothetical explanations.

  6. Antiviral treatment of idiopathic sudden sensorineural hearing loss : A prospective, randomized, double-blind clinical trial

    NARCIS (Netherlands)

    Stokroos, RJ; Albers, FWJ; Tenvergert, EM

    1998-01-01

    A subclinical viral labyrinthitis has been postulated in the literature to elicit Idiopathic Sudden Sensorineural Hearing Loss. An etiological role for the herpes virus family is assumed. Corticosteroids possess a limited beneficial effect on hearing recovery in ISSHL. In this study, the therapeutic

  7. Prognostic effect of hyperbaric oxygen therapy starting time for sudden sensorineural hearing loss.

    Science.gov (United States)

    Yıldırım, Erol; Murat Özcan, K; Palalı, Mehmet; Cetin, Mehmet Ali; Ensari, Serdar; Dere, Hüseyin

    2015-01-01

    Sudden sensorineural hearing loss is one of the otological emergencies whose pathogenesis is uncertain and associated with total or partial loss of hearing function. The aim of this study was to investigate whether the hyperbaric oxygen therapy starting time affects the management of sudden sensorineural hearing loss. Fifty-nine patients with sudden sensorineural hearing loss admitted to our clinic between 2008 and 2012 were retrospectively included in this study. All patients received hyperbaric oxygen therapy. In addition, each patient received intravenous piracetam and 37 patients received steroid therapy. Hyperbaric oxygen therapy was initiated between 1 and 7 days with 20 patients determined as Group A, between 8 and 14 days with 25 patients determined as Group B and between 15 and 28 days with 14 patients determined as Group C. Hearing gains of these three groups were statistically evaluated. Each of them showed statistically significant improvement. Lowest hearing gain was observed in Group C and the gain of this group was statistically less than the other two groups. There was no significant difference between the hearing gains of the Group A and Group B. Starting hyperbaric oxygen therapy in patients with sudden sensorineural hearing loss within the first 14 days has positive effect on the prognosis of the disease.

  8. Profile and Stability of Sensorineural Hearing Loss in Persistent Pulmonary Hypertension of the Newborn.

    Science.gov (United States)

    Walton, Joseph P.; Hendricks-Munoz, Karen

    1991-01-01

    This study found that 19 of 51 infants with persistent pulmonary hypertension of the newborn were diagnosed with sensorineural hearing loss, an incidence 25 times greater than that of intensive care unit infants in general. Treatment durations with mechanical ventilation were significantly longer for the hearing-impaired group compared to the…

  9. Bilateral sudden sensorineural hearing loss as an initial presentation of myelodysplastic syndrome.

    Science.gov (United States)

    Lee, Eun Jung; Yoon, Yong Joo

    2012-01-01

    This study reports an unusual case in which myelodysplastic syndrome presented bilateral sudden sensorineural hearing loss as the first symptom of the disease. The aural symptoms and signs such as tinnitus, dizziness, and hearing impairment of a hematologic disease are common. However, sudden hearing loss as the first manifestation of a hematologic disease is extremely rare. A 76-year-old woman presented with bilateral sudden hearing loss. The patient was found to have myelodysplastic syndrome during a workup for her hearing loss. Unfortunately, the patient's hearing loss did not improve after the medical treatment.

  10. High fibrinogen in peripheral blood correlates with poorer hearing recovery in idiopathic sudden sensorineural hearing loss.

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    Sho Kanzaki

    Full Text Available OBJECTIVES: We used hearing tests and peripheral blood sample analyses to characterize the pathology of idiopathic sudden sensorineural hearing loss (ISSNHL and to identify possible prognostic factors for predicting recovery of hearing loss. STUDY DESIGN: A retrospective, multicenter trial was conducted. METHODS: Two hundred three patients examined within 7 days after the onset of ISSNHL received prednisone with lipo-prostaglandin E1. Pure-tone auditory tests were performed before and after treatment with these drugs. Blood tests were performed on blood samples collected during the patients' initial visit to our clinic. RESULTS: In all patients, elevated white blood cell (WBC counts, fasting blood sugar levels, HgbA1c, and erythrocyte sedimentation rate (ESR significantly correlated with high hearing threshold measurements obtained on the initial visit. High fibrinogen levels, WBC counts, ESR, and low concentrations of fibrinogen degradation products (FDP were associated with lower hearing recovery rates. Additionally, different audiogram shapes correlated with different blood test factors, indicating that different pathologies were involved. CONCLUSIONS: High fibrinogen levels measured within seven days after ISSNHL onset correlated with poorer hearing recovery. This may be a consequence of ischemia or infections in the inner ear. The high WBC counts also observed may therefore reflect an immune response to inner ear damage induced by ischemic changes or infections. Our data indicate that therapeutic strategies should be selected based on the timing of initial treatment relative to ISSNHL onset.

  11. The clinical characteristics and treatment for sudden sensorineural hearing loss with vestibular schwannoma.

    Science.gov (United States)

    Lin, Chang; Gong, Qilin; Zuo, Wenjing; Zhang, Rong; Zhou, Aidong

    2015-04-01

    The aim of this study is to analyze the clinical characteristics and treatment of sudden sensorineural hearing loss (SSNHL) patients with vestibular schwannoma (VS). The clinical features of the VS patients were explored by retrospectively analyzing the clinical data from 542 cases of SSNHL patients between January 2008 and March 2013. There were 10 cases (10 ears) diagnosed with VS in 542 cases of SSNHL patients (10 ears, 1.85 %), 3 males, 7 females, with a range of 28-57 years. Among all the cases, eight patients with abnormal ABR, ten with ear ipsilateral stapedius reflexes which were completely not elicited and seven patients with healthy ear contralateral stapedius reflexes which were completely not elicited. Neuromas were classified by Koos grades according to size (8 of grade I, 1 of grade II, 1 of grade IV). Eight small VS  patients were taken waiting and MRI therapy strategies. Meanwhile, we used glucocorticoid treatment and timely and short-term medication to improve the microcirculation of the inner ear for these patients. And four cases' hearing was improved. Some vestibular schwannomas have SSNHL as initial symptoms, especially the small ones in internal auditory canal. To prevent misdiagnosis or leak-diagnosis, MRI should be performed as a routine test for SSNHL, and ABR is sometimes necessary for SSNHL patients. It is also necessary to give appropriate treatment to protect hearing of the small vestibular schwannoma patients whose first symptoms are diagnosed as SSNHL in acute phase.

  12. Endothelial dysfunction in patients with sudden sensorineural hearing loss

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    Nezamoddin Berjis

    2016-01-01

    Full Text Available Background: Endothelial dysfunction probably has a role in the etiology of sudden sensorineural hearing loss (SSNHL. The aim of this study was determining of the relationship between endothelial dysfunction and SSNHL. Materials and Methods: In a case-control study, 30 patients with SSNHL and 30 otherwise healthy age and sex-matched controls were studied. Demographic data gathered included age, gender, family history of SSNHL, and history of smoking, cardiovascular disease, hypertension, diabetes, and dyslipidemia. Laboratory data included measurement of hemoglobin, fasting blood sugar (FBS and lipid profile. Endothelial function was assessed by measuring flow-mediated dilation (FMD. Results: The two groups were the same in age (47.9 ± 9.3 and 48.1 ± 9.6 years, P = 0.946 with female/male ratio of 1:1 in both groups. Diabetes and dyslipidemia were more frequent in patients than controls (20% vs. 0%, P = 0.024. Brachial artery diameter was greater in patients than controls before (4.24 ± 0.39 vs. 3.84 ± 0.23 mm, P < 0.001 and after ischemia (4.51 ± 0.43 vs. 4.28 ± 0.27 mm, P = 0.020, but FMD was lower in patients than controls (6.21 ± 3.0 vs. 11.52 ± 2.30%, P < 0.001. Binary logistic regression analysis showed that FMD was associated with SSNHL independent from FBS and lipid profile (odds ratio [95% confidence interval] =0.439 [0.260-0.740], P = 0.002. Conclusion: Endothelial dysfunction, among other cardiovascular risk factors, is associated with SSNHL. This association is independent from other cardiovascular risk factors including diabetes and dyslipidemia.

  13. Phosphodiesterase 4D gene polymorphisms in sudden sensorineural hearing loss.

    Science.gov (United States)

    Chien, Chen-Yu; Tai, Shu-Yu; Wang, Ling-Feng; Hsi, Edward; Chang, Ning-Chia; Wang, Hsun-Mo; Wu, Ming-Tsang; Ho, Kuen-Yao

    2016-09-01

    The phosphodiesterase 4D (PDE4D) gene has been reported as a risk gene for ischemic stroke. The vascular factors are between the hypothesized etiologies of sudden sensorineural hearing loss (SSNHL), and this genetic effect might be attributed for its role in SSNHL. We hypothesized that genetic variants of the PDE4D gene are associated with susceptibility to SSNHL. We conducted a case-control study with 362 SSNHL cases and 209 controls. Three single nucleotide polymorphisms (SNPs) were selected. The genotypes were determined using TaqMan technology. Hardy-Weinberg equilibrium (HWE) was tested for each SNP, and genetic effects were evaluated according to three inheritance modes. We carried out sex-specific analysis to analyze the overall data. All three SNPs were in HWE. When subjects were stratified by sex, the genetic effect was only evident in females but not in males. The TT genotype of rs702553 exhibited an adjusted odds ratio (OR) of 3.83 (95 % confidence interval = 1.46-11.18) (p = 0.006) in female SSNHL. The TT genotype of SNP rs702553 was associated with female SSNHL under the recessive model (p = 0.004, OR 3.70). In multivariate logistic regression analysis, TT genotype of rs702553 was significantly associated with female SSNHL (p = 0.0043, OR 3.70). These results suggest that PDE4D gene polymorphisms influence the susceptibility for the development of SSNHL in the southern Taiwanese female population. PMID:26521189

  14. Phosphodiesterase 4D gene polymorphisms in sudden sensorineural hearing loss.

    Science.gov (United States)

    Chien, Chen-Yu; Tai, Shu-Yu; Wang, Ling-Feng; Hsi, Edward; Chang, Ning-Chia; Wang, Hsun-Mo; Wu, Ming-Tsang; Ho, Kuen-Yao

    2016-09-01

    The phosphodiesterase 4D (PDE4D) gene has been reported as a risk gene for ischemic stroke. The vascular factors are between the hypothesized etiologies of sudden sensorineural hearing loss (SSNHL), and this genetic effect might be attributed for its role in SSNHL. We hypothesized that genetic variants of the PDE4D gene are associated with susceptibility to SSNHL. We conducted a case-control study with 362 SSNHL cases and 209 controls. Three single nucleotide polymorphisms (SNPs) were selected. The genotypes were determined using TaqMan technology. Hardy-Weinberg equilibrium (HWE) was tested for each SNP, and genetic effects were evaluated according to three inheritance modes. We carried out sex-specific analysis to analyze the overall data. All three SNPs were in HWE. When subjects were stratified by sex, the genetic effect was only evident in females but not in males. The TT genotype of rs702553 exhibited an adjusted odds ratio (OR) of 3.83 (95 % confidence interval = 1.46-11.18) (p = 0.006) in female SSNHL. The TT genotype of SNP rs702553 was associated with female SSNHL under the recessive model (p = 0.004, OR 3.70). In multivariate logistic regression analysis, TT genotype of rs702553 was significantly associated with female SSNHL (p = 0.0043, OR 3.70). These results suggest that PDE4D gene polymorphisms influence the susceptibility for the development of SSNHL in the southern Taiwanese female population.

  15. Risk of sudden sensorineural hearing loss in stroke patients

    Science.gov (United States)

    Kuo, Chin-Lung; Shiao, An-Suey; Wang, Shuu-Jiun; Chang, Wei-Pin; Lin, Yung-Yang

    2016-01-01

    Abstract Poststroke sudden sensorineural hearing loss (SSNHL) can hinder communication between patients and healthcare professionals, thereby restricting participation in rehabilitation programs and limiting improvements in physical performance. However, the relationship between stroke and SSNHL remains unclear. This study employed a nationwide population-based dataset to investigate the relationship between stroke and SSNHL. The Taiwan Longitudinal Health Insurance Database was used to compile data from 11,115 stroke patients and a comparison cohort of 33,345 matched nonstroke enrollees. Each patient was followed for 5 years to identify new-onset SSNHL. Stratified Cox proportional-hazard regression analysis was used to examine the association of stroke with subsequent SSNHL. Among the 44,460 patients, 66 patients (55,378 person-years) from the stroke cohort and 105 patients (166,586 person-years) from the comparison cohort were diagnosed with SSNHL. The incidence of SSNHL was approximately twice as high among stroke patients than among nonstroke patients (1.19 and 0.63/1000 person-years, respectively). Stroke patients had a 71% increased risk of SSNHL, compared with nonstroke patients (adjusted hazard ratio [HR] 1.71, 95% confidence interval [CI] 1.24–2.36). We also observed a remarkable increase in risk of SSNHL in stroke patients within 1-year of follow-up (adjusted HR 5.65, 95% CI 3.07–10.41) or under steroid therapy during hospitalization (adjusted HR 5.14, 95% CI 2.08–12.75). Patients with stroke had a higher risk of subsequent SSNHL compared with patients without stroke. In particular, stroke patients within 1-year follow-up and those undergoing steroid therapy during hospitalization should be treated with the utmost caution, considering that the risk of SSNHL increases by more than 5-fold. PMID:27603402

  16. Sudden sensorineural hearing loss: a review of diagnosis, treatment, and prognosis.

    Science.gov (United States)

    Kuhn, Maggie; Heman-Ackah, Selena E; Shaikh, Jamil A; Roehm, Pamela C

    2011-09-01

    Sudden sensorineural hearing loss (SSNHL) is commonly encountered in audiologic and otolaryngologic practice. SSNHL is most commonly defined as sensorineural hearing loss of 30 dB or greater over at least three contiguous audiometric frequencies occurring within a 72-hr period. Although the differential for SSNHL is vast, for the majority of patients an etiologic factor is not identified. Treatment for SSNHL of known etiology is directed toward that agent, with poor hearing outcomes characteristic for discoverable etiologies that cause inner ear hair cell loss. Steroid therapy is the current mainstay of treatment of idiopathic SSNHL in the United States. The prognosis for hearing recovery for idiopathic SSNHL is dependent on a number of factors including the severity of hearing loss, age, presence of vertigo, and shape of the audiogram.

  17. Does acute sensorineural deafness befall to urgent conditions?

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    Čvorović Ljiljana

    2009-01-01

    Full Text Available Background/Aim. Idiopathic sudden sensorineural hearing loss (ISSHL is one of the most controversial issues in otology. The aim of this study was to determine whether a delay in treatment has any influence on hearing recovery in ISSHL. Method. This study was designed as a retrospective evaluation of an electronic patient data base of the University Hospital Zürich from January 1995 to August 2006. Five hundred and forty one patients with a sudden hearing loss were identified. The standard treatment was carbogen inhalation (95% O2 and 5% CO2 eight times per day in the duration of 30 minutes and prednisone orally (100 mg in one morning dose for 7 days. Factor that was analyzed included the interval between the onset of symptoms and the beginning of the treatment. The initial hearing loss was described using the pure tone average (PTA in dB hearing level at 4 frequencies (0.5, 1, 2 and 4 kHz. Hearing gain was expressed either as absolute hearing gain (dB values from initial PTA minus dB values from final PTA or as relative hearing gain (absolute hearing gain divided by initial PTA minus baseline PTA × 100. Significant recovery of hearing was defined as the final PTA ≤ 30 dB (or same as PTA of the opposite ear. Results. An absolute hearing gain between the initial audiogram and the final audiogram was 15.1 dB. The mean relative hearing gain was 47%. Three hundred one (57% patients had a significant recovery of hearing, and 228 (43% had not. If the patients received treatment in the first 24 hours after onset of symptoms, then the rate of significant recovery was 56%, and no significant difference existed between this group and the patients who received the therapy after 24 hours, but within seven days (χ2 = 0.007, DF = 1, p > 0.01. Conclusion. These results suggest that it is not critical to begin the treatment of ISSHL immediately as an emergency, but within seven days.

  18. [Inner Ear Hearing Loss Part II: Sudden Sensorineural Hearing Loss, Therapeutic Options].

    Science.gov (United States)

    Hesse, Gerhard

    2016-07-01

    The great majority of hearing disorders generates from pathologies in the inner ear, mainly the outer hair cells, as mentioned in the first part of this review. Very often, however, hearing loss appears suddenly and even without external causes like noise exposure. This sudden hearing loss is mostly unilateral, recovers very often spontaneously and should be treated, if persisting. Only in this acute stage there are therapeutic options available. If the inner ear hearing loss is chronic there is no curative therapy, an effective management of the hearing disorder is only possible through rehabilitation. This is due to the fact, that hair cells of all mammals, incl. humans, have no regenerative capacity and neither pharmaceutic agents nor other means can induce regeneration and recovery of hair cells. Even a gen-therapy is not available yet. In the second part of this review the main focus lies in sudden hearing loss and general therapeutic options for inner ear hearing loss. PMID:27392187

  19. [Inner Ear Hearing Loss Part II: Sudden Sensorineural Hearing Loss, Therapeutic Options].

    Science.gov (United States)

    Hesse, Gerhard

    2016-07-01

    The great majority of hearing disorders generates from pathologies in the inner ear, mainly the outer hair cells, as mentioned in the first part of this review. Very often, however, hearing loss appears suddenly and even without external causes like noise exposure. This sudden hearing loss is mostly unilateral, recovers very often spontaneously and should be treated, if persisting. Only in this acute stage there are therapeutic options available. If the inner ear hearing loss is chronic there is no curative therapy, an effective management of the hearing disorder is only possible through rehabilitation. This is due to the fact, that hair cells of all mammals, incl. humans, have no regenerative capacity and neither pharmaceutic agents nor other means can induce regeneration and recovery of hair cells. Even a gen-therapy is not available yet. In the second part of this review the main focus lies in sudden hearing loss and general therapeutic options for inner ear hearing loss.

  20. Magnetic resonance imaging of the inner ear in patients with idiopathic sudden sensorineural hearing loss

    NARCIS (Netherlands)

    Stokroos, RJ; Albers, FWJ; Krikke, AP; Casselman, JW

    1998-01-01

    Although gadolinium-enhanced magnetic resonance imaging (Gd-MRI) has been used to indicate the presence of a subclinical labyrinthitis in patients with idiopathic sudden sensorineural hearing loss (ISSHL), its sensitivity in daily clinical practice is unknown. We describe Gd-MRI findings in 27 ISSHL

  1. Sensorineural hearing impairment in patients with Pmp22 duplication, deletion, and frameshift mutations.

    NARCIS (Netherlands)

    Verhagen, W.I.M.; Huygen, P.L.M.; Gabreëls-Festen, A.A.W.M.; Engelhart, M.J.; Mierlo, P.J. van; Engelen, B.G.M. van

    2005-01-01

    OBJECTIVE: To characterize and distinguish the types of sensorineural hearing impairment (SNHI) that occur in hereditary motor and sensory neuropathy Type 1a (HMSN-1a) and hereditary neuropathy with liability to pressure palsies (HNPP), which are caused by deletion or frameshift mutation. STUDY DESI

  2. Megadolicho basilar artery as a cause of asymmetrical sensorineural hearing loss - case report

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    Melo, Antonio Antunes

    2011-07-01

    Full Text Available Introduction: At the differentiated diagnosis of asymmetrical sensorineural hearing losses, vascular disorders are present, one of which is megadolicho basilar artery. This disease is generally asymptomatic, and when symptoms are found, they can be caused by a compression or ischemia. Clinically, sensorineural hearing loss, tinnitus, headache, facial hypoesthesia, trigeminal neuralgia, vertigo, diplopia and facial palsy, among others, are likely to occur. The image examination of choice for its diagnosis is nuclear magnetic resonance. The megadolicho basilar artery therapy can be surgical or conservative, according to the associated findings. A multidisciplinary approach, including a neurologist, neurosurgeon and an otorhinolaryngologist is recommended for a proper administration of the case. Objective: Report the case of a patient with asymmetrical sensorineural hearing loss, diagnosed of megadolicho basilar artery. Case report: JBS, 57-year-old white male with a history of asymmetrical sensorineural hearing loss and bilateral whistle-like tinnitus for several years. The otorhinolaryngologic evaluation, including otoscopy, anterior rhinoscopy and oral pharynx, was normal. Final Comments: The treatment consisted in following up with the patient, controlling the tinnitus by drugs and using an individual sound amplification apparatus on the left ear.

  3. Early detection of sensorineural hearing loss in Muckle-Wells-syndrome

    OpenAIRE

    Kuemmerle-Deschner, Jasmin B; Koitschev, Assen; Tyrrell, Pascal N; Plontke, Stefan K.; Deschner, Norbert; Hansmann, Sandra; Ummenhofer, Katharina; Lohse, Peter; Koitschev, Christiane; Benseler, Susanne M.

    2015-01-01

    Background Muckle-Wells-syndrome (MWS) is an autoinflammatory disease characterized by systemic and organ-specific inflammation due to excessive interleukin (IL)-1 release. Inner ear inflammation results in irreversible sensorineural hearing loss, if untreated. Early recognition and therapy may prevent deafness. The aims of the study were to characterize the spectrum of hearing loss, optimize the otologic assessment for early disease and determine responsiveness to anti-IL-1-therapy regarding...

  4. Intratympanic steroid therapy for treatment of idiopathic sudden sensorineural hearing loss.

    Science.gov (United States)

    Bear, Zachary W; Mikulec, Anthony A

    2014-01-01

    Idiopathic sudden sensorineural hearing loss (ISSHL) is the sudden loss of unilateral hearing of unknown etiology. The standard treatment consist of a high dose oral steroid taper. This article serves to review the current literature on intratympanic steroid injections for ISSHL. Current literature suggested intratympanic steroids are equivalent to oral steroid therapy, primary combined therapy is superior to either alone and intratympanic steroids should be offered for salvage therapy in ISSHL.

  5. Prevalence of otitis media with effusion in children with bilateral sensorineural hearing loss.

    OpenAIRE

    Das, V K

    1990-01-01

    A cohort of 164 children born within the defined boundaries of greater Manchester during the years 1981 to 1984 inclusive were identified as having bilateral sensorineural hearing loss, giving a prevalence of 1.2/1000 population of 1/817 births. Ninety three children developed an additional conductive hearing loss secondary to otitis media with effusion lasting more than three months and 39 of these (42%) required surgical treatment. Those with congenital infections, adverse perinatal factors...

  6. Intratympanic injection of dexamethasone for treatment of tinnitus in patients with sudden sensorineural hearing loss

    Directory of Open Access Journals (Sweden)

    Tadao Yoshida

    2012-01-01

    Full Text Available The purpose of this study is to test the effectiveness of intratympanic dexamethasone injections as a treatment for severe tinnitus in idiopathic sudden sensorineural hearing loss (SNHL. We studied 37 patients who received intratympanic dexamethasone injections and 14 control patients who did not receive it, with severe tinnitus after onset of unilateral sudden SNHL. Hearing level did not change during this study in any patient. The relationship between the duration of tinnitus and effectiveness of treatment was investigated in sudden SNHL. We used a visual analogue scale to evaluate 51 patients with severe tinnitus at the stage of stable hearing level after idiopathic sudden sensorineural hearing loss. Forty-one per cent of patients showed significant improvement after treatment. The average period between onset of sudden sensorineural hearing loss and initiation of intratympanic dexamethasone injection was significantly shorter (207 days in the improved group than in the unchanged group (482 days (P<0.001. In control group, one of 14 patients presented significant improvement spontaneously. Intratympanic dexamethasone treatment may be effective in treatment of severe tinnitus after sudden SNHL at the stage of stable hearing level, and the shorter the period from onset of sudden deafness to the start of intratympanic dexamethasone treatment, the greater the improvement in tinnitus that can be expected.

  7. Variables with prognostic value in the onset of idiopathic sudden sensorineural hearing loss

    Directory of Open Access Journals (Sweden)

    Eduardo Amaro Bogaz

    2015-10-01

    Full Text Available ABSTRACT INTRODUCTION: The establishment of an individualized prognostic evaluation in patients with a diagnosis of idiopathic sudden sensorineural hearing loss (ISSHL remains a difficult and imprecise task, due mostly to the variety of etiologies. Determining which variables have prognostic value in the initial assessment of the patient would be extremely useful in clinical practice. OBJECTIVE: To establish which variables identifiable at the onset of idiopathic sudden sensorineural hearing loss have prognostic value in the final hearing recovery. METHODS: Prospective, longitudinal cohort study. Patients with ISSHL followed by the Department of Otology-Neurotology of a quaternary hospital were included. The following variables were evaluated and correlated with final hearing recovery: age, gender, vertigo, tinnitus, initial degree of hearing loss, contralateral ear hearing, and elapsed time to treatment. RESULTS: 127 patients with ISSHL were evaluated. Rates of absolute and relative recovery were 23.6 dB and 37.2% respectively. Complete hearing improvement was observed in 15.7% patients; 27.6% demonstrated significant improvement and improvement was noted in 57.5%. CONCLUSION: During the onset of ISSHL, the following variables were correlated with a worse prognosis: dizziness, profound hearing loss, impaired hearing in the contralateral ear, and delay to start treatment. Tinnitus at the onset of ISSHL correlated with a better prognosis.

  8. Intratympanic steroid treatment for idiopathic sudden sensorineural hearing loss after failure of intravenous therapy.

    Science.gov (United States)

    Ferri, Emanuele; Frisina, Antonio; Fasson, Anna Chiara; Armato, Enrico; Spinato, Giacomo; Amadori, Maurizio

    2012-01-01

    Purpose. The aim of this study is the investigation of the effectiveness of intratympanic steroids therapy (IST) in patients with idiopathic sudden sensorineural hearing loss (ISSHL) who had not responded to intravenous treatment, evaluating the overall hearing recovery and comparing the results with different variables. Materials and Methods. Our study consisted of 55 patients with refractory ISSHL who, at the end of 10 days of therapy with intravenous steroids, had puretone 4-frequency average (PTA) of worse than 30 dB. The patients received 0.5 mL of methylprednisolone by direct intratympanic injection. The procedure was carried out up to 7 times within a 20-days period. Statistical analysis was carried out. Results. Overall 29 patients (52.7%) showed improvement in PTA, 24 (43.8%) had no change in hearing, and 2 (3.5%) worsened. There was a significant statistical correlation between hearing recovery and time to onset of symptoms, severity of hearing loss and frequency of hearing loss. Conclusions. IST is an effective and safe therapy in sudden sensorineural hearing loss cases that are refractory to standard treatment. The earlier IST, the hearing losses less than 90 dB and the involvement of the low frequencies seem to influence positively the hearing recovery.

  9. Ethics of Placebo Control in Trials for Idiopathic Sudden Sensorineural Hearing Loss.

    Science.gov (United States)

    Maldonado Fernández, Miguel; Kornetsky, Susan; Rubio Rodriguez, Laura

    2016-07-01

    Idiopathic sudden sensorineural hearing loss (ISSHL) involves sudden loss of hearing from cochlear or retrocochlear origin of unknown cause. Systemic corticosteroids may be considered in the management of ISSNHL. However, an updated Cochrane systematic review concludes that "the value of steroids in the treatment of idiopathic sudden sensorineural hearing loss remains unclear since the evidence obtained from randomized controlled trials is contradictory in outcome." Therefore, a new clinical trial that addresses this question is mandatory. A first step in its design is to determine if placebo control would be ethically acceptable. We conclude that there is equipoise (uncertainty) about the use of corticosteroids for ISSHL. A new trial is justified-but with the inclusion of interim analyses to detect early imbalances on efficacy or safety and with the ability to stop the trial if needed. PMID:27371619

  10. Recurrent Sudden Sensorineural Hearing Loss in a Patient with Aortic Aneurysm

    Directory of Open Access Journals (Sweden)

    Mehmet Kilickaya

    2014-12-01

    Full Text Available Etiologies of sudden sensorineural hearing loss (SSNHL include factors such as viral infections, embolism, aneurysm and vascular events. A 63-year-old male patient with a history of hypertension and aortic aneurysm surgery referred to our clinic with complaints of sensorineural hearing loss. The patient fully recovered after medical treatment. He had another SSNHL attack three months later; the examinations revealed that the recurrence of the patient%u2019s aortic aneurysms, which suggested that the etiology might be the microembolism associated with aneurysm in that case. We did not consider hyperbaric oxygen treatment (HBOT an option because it posed a relative risk for the patient. Additionally, as the patient underwent an operation primarily for aneurysm, the SSNHL treatment was interrupted, which resulted in permanent hearing loss. In conclusion, aortic aneurysm is a serious disease that may result in SSNHL, and might affect therapeutic options for this disease.

  11. Ethics of Placebo Control in Trials for Idiopathic Sudden Sensorineural Hearing Loss.

    Science.gov (United States)

    Maldonado Fernández, Miguel; Kornetsky, Susan; Rubio Rodriguez, Laura

    2016-07-01

    Idiopathic sudden sensorineural hearing loss (ISSHL) involves sudden loss of hearing from cochlear or retrocochlear origin of unknown cause. Systemic corticosteroids may be considered in the management of ISSNHL. However, an updated Cochrane systematic review concludes that "the value of steroids in the treatment of idiopathic sudden sensorineural hearing loss remains unclear since the evidence obtained from randomized controlled trials is contradictory in outcome." Therefore, a new clinical trial that addresses this question is mandatory. A first step in its design is to determine if placebo control would be ethically acceptable. We conclude that there is equipoise (uncertainty) about the use of corticosteroids for ISSHL. A new trial is justified-but with the inclusion of interim analyses to detect early imbalances on efficacy or safety and with the ability to stop the trial if needed.

  12. SENSORINEURAL HEARING LOSS IN YOUNG ADULTS WITH BMI OF 25 OR MORE

    Directory of Open Access Journals (Sweden)

    Shashikala

    2015-04-01

    Full Text Available BACKGROUND: A Body mass index [BMI] of 25 or greater is a significant health problem associated with a variety of disorders and in adults it has been found to be a risk factor for hearing loss. Higher BMI is independently associated with increased hearing loss. We investigated the hypothesis that young adults with a BMI of 25 or more are at increased risk of mild sensorineural hearing loss. AIMS AN D OBJECTIVES: To assess hearing acuity in individuals with high BMI (≥25 by audiometric assessment and compare it with the control group (BMI <25. SETTINGS AND DESIGN : A comparative and cross sectional study among volunteers residing in Bengaluru. METHODS AND MATERIAL : Data collected from 2 groups containing 30 participants each, test group contained individual with a BMI of 25 or more and the control group consisted individuals with BMI of <25, in the age group of 18 - 35 yrs. Pure tone audiometry was carried out across various frequencies (0. 5, 1, 2, 4, 6, 8 kHz in both groups. STATISTICAL ANALYSIS: Student t - test was used to compare hearing thresholds across various frequencies in both groups. RESULTS: Compared to control group, high BMI (≥25 was associated with increased pure tone hearing thresholds across lower frequencies (0. 5, 1, 2 kHz. The degree of hearing loss is mild (26 - 40dB . CONCLUSIONS: This study demonstrates that young adults with a BMI of 25 or more are at increasing risk of mild sensorineural hearing loss.

  13. Clinical Study on 136 Children with Sudden Sensorineural Hearing Loss

    Directory of Open Access Journals (Sweden)

    Feng-Jiao Li

    2016-01-01

    Conclusions: CSSNHL commonly occurs unilaterally and results in severe hearing loss. Initial severe hearing loss and bilateral hearing loss are negative prognostic factors for hearing recovery, while positive prognostic factors include tinnitus, gender, the ascending type audiogram, early treatment, identifiable ABR waves, and DPOAEs. Age, vertigo, and ear fullness are not correlated with the recovery. Some serologic indicators, including the level of WBC, platelet, homocysteine, ALP, positive CMV IgG antibody, fibrinogen, and some immunologic indicators, are closely related to CSSNHL.

  14. Bilateral sudden sensorineural hearing loss caused by leptomeningeal carcinomatosis: case report and review.

    Science.gov (United States)

    Öztürk, Murat; Ila, Kadri; Düzgöl, Cihan; Akansel, Gür; Almaç, Ahmet

    2014-01-01

    Leptomeningeal carcinomatosis is a rare condition characterized by diffuse infiltration of the meninges after the metastasis of the solid tumors. Bilateral sudden hearing loss is a rare initial symptom. In this article, we report a 44-year-old male patient with bilateral sudden hearing loss and dizziness. Magnetic resonance imaging showed involvement of the bilateral vestibulocochlear nerves. Malignant cells were detected in cerebrospinal fluid cytology. To the best of our knowledge, leptomeningeal carcinomatosis due to duodenum adenocarcinoma has not been reported before in the English literature. Leptomeningeal carcinomatosis should be kept in mind in patients who have bilateral sudden sensorineural hearing loss.

  15. Pleiotropy in Coffin-Lowry syndrome: sensorineural hearing deficit and premature tooth loss as early manifestations.

    Science.gov (United States)

    Hartsfield, J K; Hall, B D; Grix, A W; Kousseff, B G; Salazar, J F; Haufe, S M

    1993-03-01

    We report on 7 patients (6 M, 1 F) with Coffin-Lowry syndrome who have a sensorineural hearing deficit in addition to developmental delay and characteristic facial changes. One of the patients also had a history of premature exfoliation of primary teeth. These are previously unappreciated clinical signs that may aid in the early diagnosis of Coffin-Lowry syndrome. Early diagnosis and recognition of a hearing deficit in the patient can lead to the use of hearing aids to help the patient achieve his or her full potential. These "new" clinical manifestations expand the phenotype of Coffin-Lowry syndrome and constitute an additional indication of pleiotropy.

  16. Early Posttreatment Audiometry Underestimates Hearing Recovery after Intratympanic Steroid Treatment of Sudden Sensorineural Hearing Loss

    Directory of Open Access Journals (Sweden)

    Benjamin J. Wycherly

    2011-01-01

    Full Text Available Objective. To review our experience with intratympanic steroids (ITSs for the treatment of idiopathic sudden sensorineural hearing loss (ISSNHL, emphasizing the ideal time to perform follow-up audiograms. Methods. Retrospective case review of patients diagnosed with ISSNHL treated with intratympanic methylprednisolone. Injections were repeated weekly with a total of 3 injections. Improvement was defined as an improved pure-tone average ≥20 dB or speech-discrimination score ≥20%. Results. Forty patients met the inclusion criteria with a recovery rate of 45% (18/40. A significantly increased response rate was found in patients having an audiogram >5 weeks after the first dose of ITS (9/13 over those tested ≤5 weeks after the first dose of ITS (9/27 (=0.03. Conclusions. Recovery from ISSNHL after ITS injections occurs more frequently >5 weeks after initiating ITS. This may be due to the natural history of sudden hearing loss or the prolonged effect of steroid in the inner ear.

  17. 3-DIMENSIONAL MAGNETIC-RESONANCE-IMAGING OF THE INNER-EAR IN IDIOPATHIC SUDDEN SENSORINEURAL HEARING-LOSS

    NARCIS (Netherlands)

    ALBERS, FWJ; DEMUYNCK, KMNP; CASSELMAN, JW

    1994-01-01

    Five patients with idiopathic sudden sensorineural hearing loss (ISSHL) were examined by a combination of high-resolution computed tomography and special magnetic resonance imaging techniques. By three-dimensional constructive interference in steady state magnetic resonance imaging excellent visuali

  18. The Design and Screening of Drugs to Prevent Acquired Sensorineural Hearing Loss

    Science.gov (United States)

    Mukherjea, Debashree; Rybak, Leonard P.; Sheehan, Kelly E; Kaur, Tejbeer; Ramkumar, Vickram; Jajoo, Sarvesh; Sheth, Sandeep

    2011-01-01

    Introduction Sensorineural hearing loss affects a high percentage of the population. Ototoxicity is a serious and pervasive problem in patients treated with cisplatin. Strategies to ameliorate ototoxicity without compromising on antitumor activity of treatments are urgently needed. Similar problems occur with aminoglycoside antibiotic therapy for infections. Noise-induced hearing loss affects a large number of people. The use of ear protection is not always possible or effective. The prevention of hearing loss with drug therapy would have a huge impact in reducing the number of persons with hearing loss from these major causes. Areas covered This review discusses significant research findings dealing with the use of protective agents against hearing loss caused by cisplatin, aminoglycoside antibiotics and noise trauma. The efficacy in animal studies and the application of these protective agents in clinical trials that are ongoing are presented. Expert opinion The reader will gain new insights into current and projected future strategies to prevent sensorineural hearing loss from cisplatin chemotherapy, aminoglycoside antibiotic therapy and noise exposure. The future appears to offer numerous agents to prevent hearing loss caused by cisplatin, aminoglycoside antibiotics and noise. Novel delivery systems will provide ways to guide these protective agents to the desired target areas in the inner ear and will circumvent problems with therapeutic interference of anti-tumor and antibiotics agents and will minimize undesired side effects. PMID:22646075

  19. A new nonsyndromic X-linked sensorineural hearing impairment linked to Xp21.2

    Energy Technology Data Exchange (ETDEWEB)

    Lalwani, A.K.; Brister, J.R.; Fex, J.; Grundfast, K.M.; Pikus, A.T.; Ploplis, B.; San Agustin, T.; Skarka, H.; Wilcox, E.R. [National Institutes of Health, Bethesda, MD (United States)

    1994-10-01

    X-linked deafness is a rare cause of hereditary hearing impairment. We have identified a family with X-linked dominant sensorineural hearing impairment, characterized by incomplete penetrance and variable expressivity in carrier females, that is linked to the Xp21.2, which contains the Duchenne muscular dystrophy (DMD) locus. The auditory impairment in affected males was congenital, bilateral, profound, sensorineural, affecting all frequencies, and without evidence of radiographic abnormality of the temporal bone. Adult carrier females manifested bilateral, mild-to-moderate high-frequency sensorineural hearing impairment of delayed onset during adulthood. Eighteen commercially available polymorphic markers from the X chromosome, generating a 10-15-cM map, were initially used for identification of a candidate region. DXS997, located within the DMD gene, generated a two-point LOD score of 2.91 at {theta} = 0, with every carrier mother heterozygous at this locus. Recombination events at DXS992 (located within the DMD locus, 3{prime} to exon 50 of the dystrophin gene) and at DXS1068 (5{prime} to the brain promoter of the dystrophin gene) were observed. No recombination events were noted with the following markers within the DMD locus: 5{prime}DYS II, intron 44, DXS997, and intron 50. There was no clinical evidence of Duchenne or Becker muscular dystrophy in any family member. It is likely that this family represents a new locus on the X chromosome, which when mutated results in nonsyndromic sensorineural hearing loss and is distinct from the heterogeneous group of X-linked hearing losses that have been previously described. 57 refs., 6 figs., 1 tab.

  20. Superficial Siderosis and Sudden Sensorineural Hearing Loss: A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Kirsti S. V. Lee

    2013-01-01

    Full Text Available This case report highlights an unusual case of sudden sensorineural hearing loss related to superficial siderosis (SS. Our patient had a craniotomy for medulloblastoma 23 years earlier, and this may represent a delayed complication related to this procedure. Magnetic resonance imaging (MRI remains the key diagnostic investigation to illustrate the imaging features of superficial siderosis and exclude other pathologies. Increased awareness of progressive and sudden hearing complications caused by SS is important in the otolaryngologic community to expedite management and better counsel patients during the consent process.

  1. Characterizing auditory processing and perception in individual listeners with sensorineural hearing loss

    DEFF Research Database (Denmark)

    Jepsen, Morten Løve; Dau, Torsten

    2011-01-01

    –438 (2008)] was used as a framework. The parameters of the cochlear processing stage of the model were adjusted to account for behaviorally estimated individual basilar-membrane inputoutput functions and the audiogram, from which the amounts of inner hair-cell and outer hair-cell losses were estimated......This study considered consequences of sensorineural hearing loss in ten listeners. The characterization of individual hearing loss was based on psychoacoustic data addressing audiometric pure-tone sensitivity, cochlear compression, frequency selectivity, temporal resolution, and intensity...

  2. [The revised version of the german guidelines "sudden idiopathic sensorineural hearing loss"].

    Science.gov (United States)

    Michel, O

    2011-05-01

    The new revised version (expires 2012) for sudden, unilateral, sensorineural hearing loss stresses the urgence but not the emergency of diagnostics and therapy in this inner ear disfunction with still increasing incidence. Minimum diagnostics should comprise ENT examination with earmicroscopy, pure tone and tuning fork hearing tests, tympano- and vestibulometry. Classification by frequency loss seems of interest in regard to different underlying pathology, which is still obscure. Therefore from experience glucocorticoids and rheological therapy are recommended in the light of some favoring recent studies. The intratympanic appliCation of glucokorticoids is considered as spare therapy.

  3. Superficial siderosis and sudden sensorineural hearing loss: a case report and review of the literature.

    Science.gov (United States)

    Lee, Kirsti S V; Sritharan, Niranjan; Forrest, Allan

    2013-01-01

    This case report highlights an unusual case of sudden sensorineural hearing loss related to superficial siderosis (SS). Our patient had a craniotomy for medulloblastoma 23 years earlier, and this may represent a delayed complication related to this procedure. Magnetic resonance imaging (MRI) remains the key diagnostic investigation to illustrate the imaging features of superficial siderosis and exclude other pathologies. Increased awareness of progressive and sudden hearing complications caused by SS is important in the otolaryngologic community to expedite management and better counsel patients during the consent process.

  4. Hearing outcome does not depend on the interval of intratympanic steroid administration in idiopathic sudden sensorineural hearing loss.

    Science.gov (United States)

    Suzuki, Hideaki; Koizumi, Hiroki; Ohkubo, Jun-Ichi; Hohchi, Nobusuke; Ikezaki, Shoji; Kitamura, Takuro

    2016-10-01

    We studied the effect of intratympanic steroid administration with different intervals on hearing outcomes in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). The subjects were 197 consecutive patients (197 ears) with ISSNHL (hearing level ≥40 dB, interval between onset and treatment ≤30 days). They received systemic administration of prednisolone (100 mg followed by tapered doses) combined with intratympanic injection of dexamethasone (4 mg/ml). Intratympanic injection was performed once a week for 4 weeks in 105 patients (long-interval group), or 4 times in 1 week in 92 patients (short-interval group). The hearing outcomes were evaluated at two points of time: 1 week from the start of treatment, and 1-2 months after the completion of treatment when the hearing level reached a plateau. There was no significant difference in the cure rate, marked-recovery rate, recovery rate, hearing gain, hearing level, or percent hearing improvement between the long- and short-interval groups at either point of time. Multiple regression analysis also showed that the final hearing level did not depend on the interval of intratympanic steroid injection. These results indicate that the hearing outcome of ISSNHL does not improve even if the interval of intratympanic injection is shortened. This implies that a lower total number of intratympanic steroid injections may be as effective as the present protocol.

  5. Coronary artery bypass grafting and sensorineural hearing loss, a cohort study

    Directory of Open Access Journals (Sweden)

    Ashraf Omer

    2005-12-01

    Full Text Available Abstract Background Sudden sensorineural hearing loss is routinely encountered by the otologist. The etiology is varied and often identifiable. One of the relatively less frequent causes is surgery. Apart from being an established entity with otological surgeries, sensorineural hearing loss has also been known to occur after non-otological procedures under general anesthesia. Commonest amongst these procedures is cardiopulmonary bypass, an association that has long been recognized. However, despite the proposition of diverse hypotheses in the past, the pathophysiology remains unclear. Methods The study is a prospective matched cohort study that will be carried out in Aga Khan University Hospital, Karachi, Pakistan. Participants among exposed would include all those patients who would be undergoing coronary artery bypass surgery in the hospital who fall under the criteria for inclusion. Unexposed group would comprise of patients undergoing a non-bypass procedure of similar duration under the same type of anesthesia who meet the selection criteria. Both these groups will undergo audiometric testing at our hospital on three different occasions during the course of this study. Initially before the procedure to test the baseline hearing capacity; then one week after the procedure to assess any changes in hearing ability following the surgery; and finally a third audiogram at six weeks follow-up to assess further changes in any hearing deficits noted during the second phase of testing. Certain variables including the subjects' demographics and those concerning the procedure itself will be noted and used later for risk factors analysis. A detailed past medical and surgical history will also be obtained. Data analysis would include calculation of relative risk and significance of the results, by running the chi-square test. Other statistical tests like Fisher exact test may then be employed to facilitate data interpretation. Continuous scale may then be

  6. Bilateral sudden sensorineural hearing loss in Staphylococcus aureus endocarditis.

    Science.gov (United States)

    Lau, Joanne Wai Ling; Ceranic, Borka; Harris, Robert; Timehin, Elwina

    2015-09-14

    This case highlights the diagnostic challenges in patients presenting with bilateral sudden sensorinueral hearing loss (SNHL). The aetiology of bilateral sudden SNHL may span several medical disciplines. Therefore, clinicians should be mindful of such presentations, and consider aetiologies beyond otological and neurological causes. We present a case of a previously healthy 51-year-old woman who presented with coryzal symptoms and sudden audiovestibular failure. Examination revealed fever, tachycardia, bilateral profound hearing loss and nystagmus. Following investigations, an initial working diagnosis of vasculitis was made. Later, blood cultures revealed methicillin-sensitive Staphylococcus aureus (MSSA) and a transoesophageal echocardiogram confirmed endocarditis. The patient made a good recovery, but the hearing loss was permanent and managed with a cochlear implant.

  7. Sudden Sensorineural Hearing Loss: The Question of Perilymph Fistula.

    Science.gov (United States)

    Backous, Douglas D.; Niparko, John K.

    1997-01-01

    Perilymph fistula (PLF) is an abnormal communication between the fluid-containing spaces of the inner ear and the air-containing spaces of the temporal bone that can cause hearing loss, tinnitus, aural fullness, vertigo, and postural instability. Diagnosis of PLF and management of those with presumed PLF are discussed. (Contains extensive…

  8. Risk factors of sensorineural hearing loss in preterm infants.

    Science.gov (United States)

    Borradori, C; Fawer, C L; Buclin, T; Calame, A

    1997-01-01

    Among 547 preterm infants of Ototoxicity appeared closely related to a prolonged administration and higher total dose of ototoxic drugs, particularly aminoglycosides and furosemide. Finally, we strongly recommend to prospectively and regularly perform audiologic assessment in sick preterm children as hearing loss is of delayed onset and in most cases bilateral and severe.

  9. Mitochondrial Sensorineural Hearing Loss: A Retrospective Study and a Description of Cochlear Implantation in a MELAS Patient

    Directory of Open Access Journals (Sweden)

    Mauro Scarpelli

    2012-01-01

    Full Text Available Hearing impairment is common in patients with mitochondrial disorders, affecting over half of all cases at some time in the course of the disease. In some patients, deafness is only part of a multisystem disorder. By contrast, there are also a number of “pure” mitochondrial deafness disorders, the most common probably being maternally inherited. We retrospectively analyzed the last 60 genetically confirmed mitochondrial disorders diagnosed in our Department: 28 had bilateral sensorineural hearing loss, whereas 32 didn't present ear's abnormalities, without difference about sex and age of onset between each single group of diseases. We reported also a case of MELAS patient with sensorineural hearing loss, in which cochlear implantation greatly contributed to the patient's quality of life. Our study suggests that sensorineural hearing loss is an important feature in mitochondrial disorders and indicated that cochlear implantation can be recommended for patients with MELAS syndrome and others mitochondrial disorders.

  10. Treatment of idiopathic sudden sensorineural hearing loss with antiviral therapy : A prospective, randomized, double-blind clinical trial

    NARCIS (Netherlands)

    Westerlaken, BO; Stokroos, RJ; Dhooge, IJM; Wit, HP; Albers, FWJ

    2003-01-01

    A subclinical viral labyrinthitis has been postulated in the literature to elicit idiopathic sudden sensorineural hearing loss (ISSHL). An etiologic role for the herpes family is assumed. Corticosteroids possess a limited beneficial effect on hearing recovery in ISSHL. In this study, we evaluated th

  11. Influnce on vestibular function caused by acute low-tone sensorineural hearing loss%对急性低频感音神经性听力损失患者前庭功能的研究

    Institute of Scientific and Technical Information of China (English)

    王静妙; 魏俊宽; 蒋新霞

    2013-01-01

    Objective: To study the vestibular function of patients with acule low-tone sensorineural hearing loss(ALHL). So we can know whether their vestibular function was influnced. Method: Vestibular function tests were performed on fifty-two ALHL patients by recording electronystagmopraphy(KNG) and staticposturography (SPG) before and after their therapy. Then made a comparison with normal. Result: Length of locus and velocity of postural sway of the ALHL subjects were significantly increased in comparison with normal(P<0.05) when eyes closed. After therapy. two(3. 8%) ALHL subjects were still recorded abnormal KNG results. Conclusion: Most ALHL subjects without vertigo symptom, but their vestibular function was abnormal, so vestibular function tests should be performed on patients with ALHL.%目的:对急性低频感音神经性听力损失(ALHL)患者进行前庭功能检查,了解该类患者的前庭功能是否异常.方法:对52例ALHL 患者在治疗前和治疗后分别进行前庭功能检查,包括眼震电图检查和静态姿势描记图检查,并与对照组进行比较.结果:52例ALHL患者重心晃动的路径总长明显延长,晃动速度明显增快,与对照组治疗前闭眼状态下相比较.差异有统计学意义(P<0.05);治疗前9例(17.3%)眼震电图检查异常,治疗后2例(3.8%)仍异常;治疗后静态姿势描记图检查与对照组比较,差异无统计学意义(P>0.05).结论:ALHL患者虽无眩晕主诉,但部分患者前庭功能已经受损,在临床工作中应对该类患者行前庭功能检查,以进一步了解其整个内耳功能状态,并应进行长期随访.

  12. Perspectives for the treatment of sensorineural hearing loss by cellular regeneration of the inner ear.

    Science.gov (United States)

    Almeida-Branco, Mario S; Cabrera, Sonia; Lopez-Escamez, Jose A

    2015-01-01

    Sensorineural hearing loss is a caused by the loss of the cochlear hair cells with the consequent deafferentation of spiral ganglion neurons. Humans do not show endogenous cellular regeneration in the inner ear and there is no exogenous therapy that allows the replacement of the damaged hair cells. Currently, treatment is based on the use of hearing aids and cochlear implants that present different outcomes, some difficulties in auditory discrimination and a limited useful life. More advanced technology is hindered by the functional capacity of the remaining spiral ganglion neurons. The latest advances with stem cell therapy and cellular reprogramming have developed several possibilities to induce endogenous regeneration or stem cell transplantation to replace damaged inner ear hair cells and restore hearing function. With further knowledge of the cellular and molecular biology of the inner ear and its embryonic development, it will be possible to use induced stem cells as in vitro models of disease and as replacement cellular therapy. Investigation in this area is focused on generating cellular therapy with clinical use for the treatment of profound sensorineural hearing loss. PMID:25459416

  13. Role of Platelet Parameters on Sudden Sensorineural Hearing Loss: A Case-Control Study in Iran.

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    Abbas Mirvakili

    Full Text Available Sudden sensorineural hearing loss (SSNHL is a common otological disorder characterized by a hearing loss greater than 30 dB over three consecutive frequencies, in less than 72 hours. It has been established that platelet parameters, such as mean platelet volume, are associated with ischemic heart events, whose clinical manifestations are similar to those of SSNHL. Hence, we aimed to determine if the platelet count, mean platelet volume and platelet distribution width are related to the occurrence and severity of sudden sensorineural hearing loss. A case-control prospective study was conducted in a teaching hospital in Iran. One hundred-eight patients with SSNHL and an equal number of healthy, age- and sex-matched controls were enrolled in the study. Peripheral venous blood samples were collected from the subjects, and the platelet count, mean platelet volume and platelet distribution width were measured with an automated blood cell counter. Analysis of the audiometry and hematological test results using SPSS22 software showed no statistical correlation between the platelet parameters and the occurrence of SSNHL, but correlation coefficients showed a significant correlation between PDW and hearing loss severity in patients group. However, further investigation is required to unequivocally establish the absence of correlation between the platelet parameters and occurrence of SSNHL.

  14. Role of Platelet Parameters on Sudden Sensorineural Hearing Loss: A Case-Control Study in Iran.

    Science.gov (United States)

    Mirvakili, Abbas; Dadgarnia, Mohammad Hossein; Baradaranfar, Mohammad Hossein; Atighechi, Saeid; Zand, Vahid; Ansari, Abdollah

    2016-01-01

    Sudden sensorineural hearing loss (SSNHL) is a common otological disorder characterized by a hearing loss greater than 30 dB over three consecutive frequencies, in less than 72 hours. It has been established that platelet parameters, such as mean platelet volume, are associated with ischemic heart events, whose clinical manifestations are similar to those of SSNHL. Hence, we aimed to determine if the platelet count, mean platelet volume and platelet distribution width are related to the occurrence and severity of sudden sensorineural hearing loss. A case-control prospective study was conducted in a teaching hospital in Iran. One hundred-eight patients with SSNHL and an equal number of healthy, age- and sex-matched controls were enrolled in the study. Peripheral venous blood samples were collected from the subjects, and the platelet count, mean platelet volume and platelet distribution width were measured with an automated blood cell counter. Analysis of the audiometry and hematological test results using SPSS22 software showed no statistical correlation between the platelet parameters and the occurrence of SSNHL, but correlation coefficients showed a significant correlation between PDW and hearing loss severity in patients group. However, further investigation is required to unequivocally establish the absence of correlation between the platelet parameters and occurrence of SSNHL.

  15. Combined Intratympanic and Systemic Steroid Therapy for Poor-Prognosis Sudden Sensorineural Hearing Loss

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    Shima Arastou

    2012-12-01

    Full Text Available Introduction: The aim of this study was to evaluate the efficacy of combined intratympanic and systemic steroid therapy compared with systemic steroid therapy alone in idiopathic sudden sensorineural hearing loss (ISSNHL patients with poor prognostic factors.     Materials and Methods: Seventy-seven patients with sudden sensorineural hearing loss (SSNHL who had at least one poor prognostic factor (age greater than 40 years, hearing loss more than 70 db, or greater than a 2-week delay between the onset of hearing loss and initiation of therapy were included in this study. Patients were randomized to the intervention group (combined intratympanic and systemic steroid therapy or the control group (systemic steroid therapy alone. All patients received oral treatment with systemic prednisolone (1 mg/kg/day for 10 days, acyclovir (2 g/day for 10 days, divided into four doses, triamterene H (daily, and omeprazole (daily, during steroid treatment, and were advised to follow a low salt diet. The intervention group also received intratympanic dexamethasone injections (0.4 ml of 4 mg/ml dexamethasone two times a week for two consecutive weeks (four injections in total. A significant hearing improvement was defined as at least a 15-db decrease in pure tone average (PTA.  Results: Among all participants, 44 patients (57.14% showed significant improvement in hearing evaluation. More patients showed hearing improvement in the intervention group than in the control group (27 patients (75% versus 17 patients (41.4%, respectively; P = 0.001.  Conclusion:  The combination of intratympanic dexamethasone and systemic prednisolone is more effective than systemic prednisolone alone in the treatment of poor-prognosis SSNHL.

  16. Relation between temporal envelope coding, pitch discrimination, and compression estimates in listeners with sensorineural hearing loss

    DEFF Research Database (Denmark)

    Bianchi, Federica; Santurette, Sébastien; Fereczkowski, Michal;

    2015-01-01

    Recent physiological studies in animals showed that noise-induced sensorineural hearing loss (SNHL) increased the amplitude of envelope coding in single auditory-nerve fibers. The present study investigated whether SNHL in human listeners was associated with enhanced temporal envelope coding......, whether this enhancement affected pitch discrimination performance, and whether loss of compression following SNHL was a potential factor in envelope coding enhancement. Envelope processing was assessed in normal-hearing (NH) and hearing-impaired (HI) listeners in a behavioral amplitude...... resolvability. For the unresolved conditions, all five HI listeners performed as good as or better than NH listeners with matching musical experience. Two HI listeners showed lower amplitude-modulation detection thresholds than NH listeners for low modulation rates, and one of these listeners also showed a loss...

  17. Complex-Tone Pitch Discrimination in Listeners With Sensorineural Hearing Loss

    DEFF Research Database (Denmark)

    Bianchi, Federica; Fereczkowski, Michal; Zaar, Johannes;

    2016-01-01

    Physiological studies have shown that noise-induced sensorineural hearing loss (SNHL) enhances the amplitude of envelope coding in auditory-nerve fibers. As pitch coding of unresolved complex tones is assumed to rely on temporal envelope coding mechanisms, this study investigated pitch......-discrimination performance in listeners with SNHL. Pitch-discrimination thresholds were obtained for 14 normal-hearing (NH) and 10 hearing-impaired (HI) listeners for sine-phase (SP) and random-phase (RP) complex tones. When all harmonics were unresolved, the HI listeners performed, on average, worse than NH listeners...... estimated in the same listeners. The estimated reduction of cochlear compression was significantly correlated with the increase in the F0DL ratio, while no correlation was found with filter bandwidth. The effects of degraded frequency selectivity and loss of compression were considered in a simplified...

  18. Working memory and referential communication – multimodal aspects of interaction between children with sensorineural hearing impairment and normal hearing peers

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    Olof eSandgren

    2015-03-01

    Full Text Available Whereas the language development of children with sensorineural hearing impairment (SNHI has repeatedly been shown to differ from that of peers with normal hearing (NH, few studies have used an experimental approach to investigate the consequences on everyday communicative interaction. This mini review gives an overview of a range of studies on children with SNHI and NH exploring intra- and inter-individual cognitive and linguistic systems during communication.Over the last decade, our research group has studied the conversational strategies of Swedish speaking children and adolescents with SNHI and NH using referential communication, an experimental analogue to problem-solving in the classroom. We have established verbal and nonverbal control and validation mechanisms, related to working memory capacity (WMC and phonological short term memory (PSTM. We present main findings and future directions relevant for the field of cognitive hearing science and for the clinical and school-based management of children and adolescents with SNHI.

  19. Prevalence of Epileptiform Discharges in Children with Sensori-Neural Hearing Loss and Behavioral Problems Compared to Their Normal Hearing Peers

    OpenAIRE

    AMIRSALARI, Susan; RADFAR, Shokoufeh; Ajallouyean, Mohammad; Saburi, Amin; Yousefi, Jaleh; NOOHI, Sima; Tavallaie, Seyed Abbas; Mahdieh HASSANALIFARD; GHAZAVI, Yasaman

    2014-01-01

    How to Cite This Article: Amirsalari S, Radfar Sh, Ajallouyean M, Saburi A, Yousefi J, Noohi S, Tavallaie SA, Hassanalifard M, Ghazavi Y. Prevalence of Epileptiform Discharges in Children with Sensori-Neural Hearing Loss and Behavioral Problems Compared to Their Normal Hearing Peers. Iran J Child Neurol. 2014 Spring 8(2):29-33.ObjectiveOveractivity and behavioral problems are common problems in children with prelingually profound sensorineural hearing loss (SNHL). Data on epileptiform electro...

  20. The noise exposed factory workers: the prevalence of sensori-neural hearing loss and their use of personal hearing protection devices.

    Science.gov (United States)

    Maisarah, S Z; Said, H

    1993-09-01

    A total of 524 industrial workers were studied. They consisted of 442 noise exposed and 82 non-noise exposed workers. The purpose was to compare the prevalence of sensori-neural hearing loss among the noise exposed and the non-noise exposed workers, to study their knowledge on the hazard of noise to hearing and the workers' attitude towards the hearing protection devices. The prevalence of sensori-neural hearing loss was significantly higher among the noise exposed workers, i.e., 83% versus 31.7% (p workers, only 5.1% were wearing them regularly. The possibility of developing hearing loss due to exposure to excessive noise was only known by 35.5% of the noise exposed workers. This awareness was found to have a positive correlation with the workers' compliance to the hearing protection devices. Our findings highlight the need for workers to be educated on the hazards of excessive noise exposure to hearing.

  1. [The specific features of the vestibular function in the patients presenting with sensorineural hearing loss of vascular genesis].

    Science.gov (United States)

    Kirichenko, I M; Popadyuk, V I; Tuzhilina, K V

    2016-01-01

    The authors consider the specific features of the vestibular function in the patients with sensorineural hearing loss of vascular genesis. The study included 60 patients at the age from 28 to 75 years presenting with sensorineural impairment of hearing of vascular genesis. All of them were examined with the use of the extended otoneurological method. The data obtained were compared with the structural changes and hemodynamic characteristics of vertebral arteries (VA) and internal carotid arteries (ICA) and with the results of magnetic resonance imaging (MRI) of the brain.

  2. Intratympanic steroid injection for sudden sensorineural hearing loss in a patient on hemodialysis.

    Science.gov (United States)

    Wu, Rui-Xin; Chen, Chun-Chi; Wang, Chih-Hung; Chen, Hsin-Chien

    2014-01-01

    Sudden sensorineural hearing loss (SSNHL) is being described with increasing incidence among patients with end-stage renal disease (ESRD) undergoing hemodialysis (HD). There are no widely accepted guidelines in the medical literature for the appropriate management of this medical emergency. Administration of systemic steroids remains the mainstay of the management of SSNHL in conjunction with the supportive treatment, in this vulnerable group of patients, as well. However, encouraged by the evolving evidence on the efficacy of the intratympanic steroid injections (ITSI) in the treatment of SSNHL among patients without renal disease--we successfully treated SSNHL in an elderly diabetic with sepsis due to bilateral pneumonitis undergoing regular HD treatment with multiple ITSI and antibiotics resulting in complete recovery of hearing function within 3 months of onset of the first symptoms.

  3. Inner ear anomalies causing congenital sensorineural hearing loss: CT and MR imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Hyun Sook; Paik, Sang Hyun; Cha, Jang Gyu; Park, Seong Jin; Joh, Joon Hee; Park, Jai Soung; Kim, Dae Ho; Lee, Hae Kyung; Kim, Shi Chan [Soonchunhyang University Bucheon Hospital, Buchon(Korea, Republic of)

    2005-07-15

    Many congenital dysplasias of the osseous labyrinth have been identified, and the differential diagnosis of these dysplasias is essential for delivering proper patient management. We retrospectively reviewed the computed tomography (CT) and magnetic resonance (MR) imaging findings of 20 children who had congenital sensorineural hearing loss. The children included cases of enlarged vestibular aqueduct and endolymphatic sac (n=8), aplasia of the semicircular canal (n=4), lateral semicircular canal-vestibule dysplasia (n=3), common cavity malformations with a large vestibule (n=1), cochlear hypoplasia (n=1), Mondini's dysplasia with large vestibular aqueduct (n=1), Mondini's dysplasia with a large vestibule (n=1), and small internal auditory canal (n=1). Six cases were unilateral. Nine cases had combined deformities, and nine cased had cochlear implants. CT was performed with a 1.0-mm thickness in the direct coronal and axial sections with using bone algorithms. MR was performed with a temporal 3D T2 FSE 10-mm scan and with routine brain images. We describe here the imaging features for the anomalies of the inner ear in patients suffering from congenital sensorineural hearing loss.

  4. Can use of a cold light source in endoscopic middle ear surgery cause sensorineural hearing loss?

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    Suat Terzi

    2016-01-01

    Full Text Available Objectives: To investigate possible sensorineural hearing loss created by the use of a cold light source in patients undergoing endoscopic tympanoplasty surgery. Materials and Methods: The medical records of 203 patients, who underwent endoscopic Type 1 tympanoplasty surgery in our ear, nose, and throat clinic between 2012 and 2015, were checked retrospectively. Ninety-one patients were male and 112 were female, and their mean age was 34.4 ± 11.2 years. Results of audiometric measurements performed during the preoperative period and repeated 1 and 3 months postsurgery were compared to each other. Results: The mean duration of the operations was determined to be 52.4 ± 9.1 min. In addition, average preoperative bone-conduction was 11.4 ± 7.4 dB nHL. However, it was 9.57 ± 7.1 dB nHL and 9.51 ± 7.4 dB nHL, respectively, in the 1st and 3rd postoperative months. Levels of postoperative average bone-conduction at the 1st and 3rd month, as well as the thresholds of bone-conduction at 500, 1000, and 2000 Hz, were significantly lower than the preoperative results (P 0.05. Conclusion: Based on our findings, the increased heat generated by the use of a cold light source during an endoscopic tympanoplasty surgery is unlikely to cause the development of sensorineural hearing loss.

  5. Uni- and multivariate models for investigating potential prognostic factors in idiopathic sudden sensorineural hearing loss.

    Science.gov (United States)

    Lionello, Marco; Staffieri, Claudia; Breda, Stefano; Turato, Chiara; Giacomelli, Luciano; Magnavita, Paola; de Filippis, Cosimo; Staffieri, Alberto; Marioni, Gino

    2015-08-01

    With a worldwide incidence estimated at 8-15 per 100,000 population a year, idiopathic sudden sensorineural hearing loss (ISSHL) is a common clinical finding for otologists. There is a shortage of information on the clinical factors capable of predicting hearing recovery and response to therapy. The aim of the present study was to retrospectively investigate the prognostic value of clinical variables in relation to hearing recovery, in a cohort of 117 consecutive patients with ISSHL. Clinical parameters (signs, symptoms, comorbidities and treatments) and audiometric data were analyzed with univariate and multivariate statistical approaches for prognostic purposes to identify any correlation with hearing recovery, also expressed according to the Wilson criteria. Univariate analysis showed that age and hypertension were significantly related to hearing outcome (p = 0.004 and p = 0.015, respectively). Elderly patients and those with hypertension were at higher risk of experiencing no hearing recovery (OR = 3.25 and OR = 2.89, respectively). Age was an independent prognostic factor on multivariate analysis (p = 0.007). Tinnitus as a presenting symptom showed a trend towards an association with hearing recovery (p = 0.07). The treatment regimen, the time elapsing between the onset of symptoms and the start of therapy (p = 0.34), and the duration of the treatment (p = 0.83) were unrelated to recovery on univariate analysis. Among the parameters considered, only age was significantly and independently related to hearing outcome. There is a need for well-designed, randomized clinical trials to enable an evidence-based protocol to be developed for the treatment of ISSHL.

  6. Corticosteroid treatment of idiopathic sudden sensorineural hearing loss: analysis of an RCT and material drawn from the Swedish national database.

    Science.gov (United States)

    Hultcrantz, Elisabeth; Nosrati-Zarenoe, Ramesh

    2015-11-01

    A randomized placebo-controlled study has demonstrated no effect of prednisolone in customary dosage on idiopathic sudden sensorineural hearing loss (ISSNHL). The aim of the present paper is to analyse a larger patient group by meta-analysis of data from the RCT together with a corresponding material drawn from the Swedish national database for ISSNHL. Data from 192 patients, 18-80 years with ISSNHL, were available. All had an acute hearing loss of at least 30 dB measured as PTA in the three most affected contiguous frequencies. All patients had been enrolled within one week after onset and evaluated by audiograms after 3 months. 45/99 (RCT) and 54/99 (the database) had been treated with prednisolone in tapering doses from 60 mg daily and 42/93 with placebo (RCT) or 51/93 with no treatment (the database). Primary outcome was the mean hearing improvement on day 90 for the different groups. A mean difference of >10 dB improvement was required to demonstrate a treatment effect for prednisolone compared to placebo/no treatment. No significant difference was seen between the prednisolone group and placebo/no treatment (p = 0.06). Total recovery was 38% in prednisolone group, 40% in the placebo and 14% in the no treatment group. Vertigo at the onset of hearing loss and age at onset had an equal negative prognostic value in all groups and signs of inflammation had a positive effect. Prednisolone in customary dosage does not influence recovery after ISSNHL.

  7. The etiology of idiopathic sudden sensorineural hearing loss - Experimental herpes simplex virus infections of the inner ear

    NARCIS (Netherlands)

    Stokroos, RJ; Albers, FWJ; Schirm, J

    1998-01-01

    Hypothesis: Experimentally induced herpes simplex virus type 1 (HSV-1) labyrinthitis provides a suitable model for idiopathic sudden sensorineural hearing loss (ISSHL). Background: Viral labyrinthitis has been postulated to play a role in the pathophysiology of ISSHL. Circumstantial evidence is pain

  8. The treatment of idiopathic sudden sensorineural hearing loss using pulse therapy : A prospective, randomized, double-blind clinical trial

    NARCIS (Netherlands)

    Westerlaken, Boris O.; Kleine, Emile de; van der Laan, Bernard; Albers, Frans

    2007-01-01

    Objectives. The etiology and treatment of idiopathic sudden sensorineural hearing loss (ISSHL) is still unclear. The anti-inflammatory effect of corticosteroids is thought to play an important part in the recovery from ISSHL. We aimed to determine whether a more powerful anti-inflammatory technique

  9. Sudden Bilateral Sensorineural Hearing Loss Associated with HLA A1-B8-DR3 Haplotype

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    G. Psillas

    2013-01-01

    Full Text Available Sudden sensorineural hearing loss may be present as a symptom in systemic autoimmune diseases or may occur as a primary disorder without another organ involvement (autoimmune inner ear disease. The diagnosis of autoimmune inner ear disease is still predicated on clinical features, and to date specific diagnostic tests are not available. We report a case of bilateral sudden hearing loss, tinnitus, intense rotatory vertigo, and nausea in a female patient in which the clinical manifestations, in addition to raised levels of circulating immune complexes, antithyroglobulin antibodies, and the presence of the HLA A1-B8-DR3 haplotype, allowed us to hypothesize an autoimmune inner ear disease. Cyclosporine-A immunosuppressive treatment in addition to steroids helped in hearing recovery that occurred progressively with normalization of the hearing function after a five-month treatment. Cyclosporine-A could be proposed as a therapeutic option in case of autoimmune inner ear disease allowing the suspension of corticosteroids that, at high dose, expose patients to potentially serious adverse events.

  10. Immune system of the inner ear as a novel therapeutic target for sensorineural hearing loss

    Directory of Open Access Journals (Sweden)

    Takayuki eOkano

    2014-09-01

    Full Text Available Sensorineural hearing loss (SNHL is a common clinical condition resulting from dysfunction in one or more parts in the auditory pathway between the inner ear and auditory cortex. Despite the prevalence of SNHL, little is known about its etiopathology, although several mechanisms have been postulated including ischemia, viral infection or reactivation, and microtrauma. Immune-mediated inner ear disease has been introduced and accepted as one SNHL pathophysiology; it responds to immunosuppressive therapy and is one of the few reversible forms of bilateral SNHL. The concept of immune-mediated inner ear disease is straightforward and comprehensible, but criteria for clinical diagnosis and the precise mechanism of hearing loss have not been determined. Moreover, the therapeutic mechanisms of corticosteroids are unclear, leading to several misconceptions by both clinicians and investigators concerning corticosteroid therapy. This review addresses our current understanding of the immune system in the inner ear and its involvement in the pathophysiology in SNHL. Treatment of SNHL, including immune-mediated inner ear disorder, will be discussed with a focus on the immune mechanism and immunocompetent cells as therapeutic targets. Finally, possible interventions modulating the immune system in the inner ear to repair the tissue organization and improve hearing in patients with SNHL will be discussed. Tissue macrophages in the inner ear appear to be a potential target for modulating the immune response in the inner ear in the pathophysiology of SNHL.

  11. Hearing Instruments for Unilateral Severe-to-Profound Sensorineural Hearing Loss in Adults: A Systematic Review and Meta-Analysis

    Science.gov (United States)

    Smith, Sandra Nelson; Lucas, Laura

    2016-01-01

    Objectives: A systematic review of the literature and meta-analysis was conducted to assess the nature and quality of the evidence for the use of hearing instruments in adults with a unilateral severe to profound sensorineural hearing loss. Design: The PubMed, EMBASE, MEDLINE, Cochrane, CINAHL, and DARE databases were searched with no restrictions on language. The search included articles from the start of each database until February 11, 2015. Studies were included that (a) assessed the impact of any form of hearing instrument, including devices that reroute signals between the ears or restore aspects of hearing to a deaf ear, in adults with a sensorineural severe to profound loss in one ear and normal or near-normal hearing in the other ear; (b) compared different devices or compared a device with placebo or the unaided condition; (c) measured outcomes in terms of speech perception, spatial listening, or quality of life; (d) were prospective controlled or observational studies. Studies that met prospectively defined criteria were subjected to random effects meta-analyses. Results: Twenty-seven studies reported in 30 articles were included. The evidence was graded as low-to-moderate quality having been obtained primarily from observational before-after comparisons. The meta-analysis identified statistically significant benefits to speech perception in noise for devices that rerouted the speech signals of interest from the worse ear to the better ear using either air or bone conduction (mean benefit, 2.5 dB). However, these devices also degraded speech understanding significantly and to a similar extent (mean deficit, 3.1 dB) when noise was rerouted to the better ear. Data on the effects of cochlear implantation on speech perception could not be pooled as the prospectively defined criteria for meta-analysis were not met. Inconsistency in the assessment of outcomes relating to sound localization also precluded the synthesis of evidence across studies. Evidence for

  12. High Total Cholesterol in Peripheral Blood Correlates with Poorer Hearing Recovery in Idiopathic Sudden Sensorineural Hearing Loss.

    Science.gov (United States)

    Quaranta, Nicola; Squeo, Valentina; Sangineto, Moris; Graziano, Giusi; Sabbà, Carlo

    2015-01-01

    Idiopathic sudden sensorineural hearing loss (ISSHL) is a common otologic emergency whose cause is still unclear. The importance of blood lipids in the pathogenesis of ISSHL is widely reported in literature. In fact elevated levels of low density lipoprotein cholesterol (LDL), total cholesterol (TC) and apolipoprotein B (Apo-B) have been proposed as risk factors for this pathology. No correlation has been described between serum lipid parameters and the prognosis of ISSHL. Aim of the present study was to identify prognostic factors associated with hearing recovery in a group of patients affected by ISSHL. Ninety-four patients with the diagnosis of ISSHL hospitalized between March 2013 and October 2014 were included in this study. Patients' blood sampling and hearing assessments were carried out. Patients were divided into two groups as "recovered" and "unrecovered", according to their response to the treatment. We found a statistically significant higher level of total cholesterol in the unrecovered group compared to the recovered one (p = 0.03). None of the other routine laboratory parameters have shown a statistically significant difference between the patients successfully treated and patients with poor outcomes. Total cholesterol concentrations may be a prognostic factor for recovery in ISSHL and should be assessed together with routine tests in patients with this condition. The other routine laboratory parameters seem to have no effect on the development and prognosis of this pathology.

  13. High Total Cholesterol in Peripheral Blood Correlates with Poorer Hearing Recovery in Idiopathic Sudden Sensorineural Hearing Loss.

    Directory of Open Access Journals (Sweden)

    Nicola Quaranta

    Full Text Available Idiopathic sudden sensorineural hearing loss (ISSHL is a common otologic emergency whose cause is still unclear. The importance of blood lipids in the pathogenesis of ISSHL is widely reported in literature. In fact elevated levels of low density lipoprotein cholesterol (LDL, total cholesterol (TC and apolipoprotein B (Apo-B have been proposed as risk factors for this pathology. No correlation has been described between serum lipid parameters and the prognosis of ISSHL. Aim of the present study was to identify prognostic factors associated with hearing recovery in a group of patients affected by ISSHL. Ninety-four patients with the diagnosis of ISSHL hospitalized between March 2013 and October 2014 were included in this study. Patients' blood sampling and hearing assessments were carried out. Patients were divided into two groups as "recovered" and "unrecovered", according to their response to the treatment. We found a statistically significant higher level of total cholesterol in the unrecovered group compared to the recovered one (p = 0.03. None of the other routine laboratory parameters have shown a statistically significant difference between the patients successfully treated and patients with poor outcomes. Total cholesterol concentrations may be a prognostic factor for recovery in ISSHL and should be assessed together with routine tests in patients with this condition. The other routine laboratory parameters seem to have no effect on the development and prognosis of this pathology.

  14. Intratympanic dexamethasone injection vs methylprednisolone for the treatment of refractory sudden sensorineural hearing loss

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    Nezamoddin Berjis

    2016-01-01

    Full Text Available Background: During the past years various drugs have been used for sudden sensorineural hearing loss (SSNHL treatment including steroids that are shown to be beneficial. Directed delivery of high doses of steroids into the inner ear is suggested for its potential and known as intratympanic steroids therapy (IST. Despite the use of dexamethasone and methylprednisolone as the traditional treatments, there are still debates about the optimal dosage, preferred drug, and the route of administration. Materials and Methods: We performed a randomized clinical trial study in which 50 patients suffering from SSNHL and resistant to standard therapy were employed. Each patient took 0.5 ml methylprednisolone (40 mg/mg along with bicarbonate or dexamethasone (4 mg/mL through direct intratympanic injection. This method was performed and scheduled once every 2 days for three times only for the dexamethasone receiving group. Hearing test was carried out and the results were analyzed according to a four-frequency (0.5, 1.0, 2.0, 3.0 kHz pure tone average (PTA and Siegel′s criteria. Results: According to Siegel′s criteria, three out of 25 (12% dexamethasone receiving patients were healed in 1 and 4 (16%, 9 (32% were respectively recovered in Siegel′s criteria 2, 3, and 9 (32% showed no recovery. In the group receiving methylprednisolone, recovery was found in 6 (24%, 8 (32%, 7 (28% patients in the Siegel′s criteria 1, 2, 3, respectively, and in 4 (16% patients no recovery was recorded. In methylprednisolone group, hearing was significantly improved compared to the dexamethasone group (P < 0.05. The general hearing improvement rate was 84% in methylprednisolone receiving patients showing a significantly higher improvement than 64% in the dexamethasone group. Conclusions: Topical intratympanic treatment with methylprednisolone is safe and an effective treatment approach for those SSNHL cases that are refractory to the common therapies by Dexamethasone.

  15. Hyperbaric oxygen therapy as salvage treatment for sudden sensorineural hearing loss: a prospective controlled study.

    Science.gov (United States)

    Pezzoli, M; Magnano, M; Maffi, L; Pezzoli, L; Marcato, P; Orione, M; Cupi, D; Bongioannini, G

    2015-07-01

    The most commonly used treatment for sensorineural sudden hearing loss (SSHL) in clinical practice is the administration of steroids; however, a favorable result is not always obtained. We studied 58 patients who failed to recover after primary treatment with IV steroids, 44 of these met our inclusion criteria (mean age 50.7, 27 males, range 30-74). We treated 23 patients (mean age 47.3, 16 males, age range 22-74) with hyperbaric oxygen therapy (HBO) (2.5 ATA for 60 min for 15 treatments), while 21 (mean age 54.5, 11 males, age range 22-71) patients refused to be treated and served as a non-randomized control group. Patients treated with HBO had a mean improvement of 15.6 dB (SD ± 15.3), with 1 of them completely healed, 5 with a good recovery, 10 with a fair recovery and 7 unchanged. Patients who were not treated had a spontaneous mean improvement of 5.0 dB (SD ± 11.4) with 3 patients with a good recovery, 1 patient with a fair recovery and 17 patients unchanged. Mean improvement was significantly better in patients treated with HBO compared to controls (p = 0.0133). Patients with worst hearing had the greater degree of improvement whether or not they were treated in the first 10 days after the onset of the hearing loss or between 11 and 30 days. In conclusion, hyperbaric oxygen therapy can lead to significant improvement of pure tone hearing thresholds in patients with SSHL who failed primary corticosteroid treatment and are within 4 weeks of the onset of deafness.

  16. Sensorineural hearing loss in patients with unilateral safe chronic suppurative otitis media

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    Manpreet Singh Nanda

    2015-06-01

    Full Text Available Background: Chronic Suppurative Otitis Media (CSOM is the major cause of hearing impairment, mainly conductive type of hearing loss. The occurrence of sensorineural hearing loss (SNHL in CSOM is controversial and the controversy is more for safe mucosal type. This study aims to assess the association between SNHL and safe mucosal CSOM and its relation to patient's age, sex, duration of disease, active or inactive disease and speech frequencies. Methods: 100 patients with unilateral mucosal type of CSOM with normal contralateral ear were included in the study. The infected ear was taken as study ear and normal ear as control ear in all patients. All patients underwent hearing assessment by pure tone audiometry for both ears. In case of active disease, ear discharge was first cleared and then audiometric assessment done. Results were statistically compared in all patients for both study and control ears using parameters of patient's age, sex, duration of disease, speech frequency and active or inactive disease. Results: There was significant higher number of study ears with CSOM having average bone conduction threshold of all frequencies above 25 decibels which implies SNHL (21% compared to control contralateral ears without infection (5%. There was higher incidence of SNHL at higher speech frequencies. The incidence also increased with age of patient and duration of disease. The incidence was higher in active stage than inactive or quiescent stage. There was no difference among males and females. Conclusion: Safe mucosal CSOM can cause significant SNHL and risk increases with increasing age, duration of disease, higher speech frequencies and presence of active disease. [Int J Res Med Sci 2015; 3(3.000: 551-555

  17. Intratympanic dexamethasone injection vs methylprednisolone for the treatment of refractory sudden sensorineural hearing loss

    Science.gov (United States)

    Berjis, Nezamoddin; Soheilipour, Saeed; Musavi, Alireza; Hashemi, Seyed Mostafa

    2016-01-01

    Background: During the past years various drugs have been used for sudden sensorineural hearing loss (SSNHL) treatment including steroids that are shown to be beneficial. Directed delivery of high doses of steroids into the inner ear is suggested for its potential and known as intratympanic steroids therapy (IST). Despite the use of dexamethasone and methylprednisolone as the traditional treatments, there are still debates about the optimal dosage, preferred drug, and the route of administration. Materials and Methods: We performed a randomized clinical trial study in which 50 patients suffering from SSNHL and resistant to standard therapy were employed. Each patient took 0.5 ml methylprednisolone (40 mg/mg) along with bicarbonate or dexamethasone (4 mg/mL) through direct intratympanic injection. This method was performed and scheduled once every 2 days for three times only for the dexamethasone receiving group. Hearing test was carried out and the results were analyzed according to a four-frequency (0.5, 1.0, 2.0, 3.0 kHz) pure tone average (PTA) and Siegel's criteria. Results: According to Siegel's criteria, three out of 25 (12%) dexamethasone receiving patients were healed in 1 and 4 (16%), 9 (32%) were respectively recovered in Siegel's criteria 2, 3, and 9 (32%) showed no recovery. In the group receiving methylprednisolone, recovery was found in 6 (24%), 8 (32%), 7 (28%) patients in the Siegel's criteria 1, 2, 3, respectively, and in 4 (16%) patients no recovery was recorded. In methylprednisolone group, hearing was significantly improved compared to the dexamethasone group (P hearing improvement rate was 84% in methylprednisolone receiving patients showing a significantly higher improvement than 64% in the dexamethasone group. Conclusions: Topical intratympanic treatment with methylprednisolone is safe and an effective treatment approach for those SSNHL cases that are refractory to the common therapies by Dexamethasone. PMID:27403406

  18. Intratympanic steroids as a salvage treatment for sudden sensorineural hearing loss? A meta-analysis.

    Science.gov (United States)

    Ng, Jia Hui; Ho, Roger Chun Man; Cheong, Crystal Shuk Jin; Ng, Adele; Yuen, Heng Wai; Ngo, Raymond Yeow Seng

    2015-10-01

    Sudden sensorineural hearing loss is typically treated with systemic steroids. The aim of this meta-analysis was to evaluate the efficacy of salvage intratympanic steroid treatment in patients who have initial treatment failure with systemic steroids. A MEDLINE literature search was performed, supported by searches of Web of Science, Biosis, and Science Direct. Articles of all languages were included. Selection of relevant publications was conducted independently by three authors. Only randomized controlled trials were considered. In one arm of the studies, the patients received salvage intratympanic steroids. In the other arm, patients did not receive further treatment. The standard difference in mean (SDM) amount of improvement in hearing threshold between patients who did and did not receive salvage intratympanic steroids was calculated. From an initial 184 studies found via the search strategy, 5 studies met inclusion criteria and were included. There was a statistically significant greater reduction in hearing threshold on pure-tone audiometry in patients who received salvage intratympanic steroids than in those who did not (SDM = -0.401, p = 0.005). Subgroup analysis showed that administration by intratympanic injection (SDM = -0.375, p = 0.013) rather than a round window catheter (SDM = -0.629, p = 0.160) yielded significant improvement in outcome. The usage of dexamethasone yielded better outcomes (SDM = -0.379, p = 0.039) than the use of methylprednisolone (SDM = -0.459, p = 0.187). No serious side effect of treatment was reported. In patients who have failed initial treatment with systemic steroids, additional treatment with salvage intratympanic dexamethasone injections demonstrate a statistically significant reduction in the hearing thresholds as compared to controls.

  19. MOTOR DEVELOPMENT AND POSTURAL CONTROL EVALUATION OF CHILDREN WITH SENSORINEURAL HEARING LOSS: A REVIEW OF THREE INEXPENSIVE ASSESSMENT TOOLS-PBS, TGMD-2, AND P-CTSIB

    Directory of Open Access Journals (Sweden)

    Rajendran VENKADESAN

    2011-02-01

    Full Text Available ObjectiveSensorineural hearing loss is believed to be the result of a physiologic malfunction in the inner ear or acoustic nerve. Depending on the rapidity of progression and severity, sensorineural hearing loss can be endlessly annoying, frightening and can constitute a permanent after effect. Moreover, there is no surgical procedure that can reverse or lessen the severity of a sensorineural hearing loss.Furthermore, children with sensorineural hearing loss present with additional disabilities in 30 to 40% of the cases. Children with profound sensorineural hearing loss may exhibit abnormalities of vestibular structures, which may lead to impairment of postural control, locomotion and gait. The development of gross motor functions such as head control, sitting and walking are likely to be delayed in these children. Evaluation of motor skills and balance are the coreof the pediatrician and physical therapist's expertise and practice. Knowledge of the reliable, valid and inexpensive assessment tools for measuring motor skills and balance are necessary to gauge the progression of the disease and the impact of treatment. In this review, we aim to summarize inexpensive tools such as TGMD-2, PBS, and P-CTSIB. Keywords: Postural control, balance, motor development, evaluation, sensorineural hearing loss.

  20. Auditory cortical responses evoked by pure tones in healthy and sensorineural hearing loss subjects: functional MRI and magnetoencephalography

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yun-ting; GENG Zuo-jun; ZHANG Quan; LI Wei; ZHANG Jing

    2006-01-01

    Background Blood oxygen level dependent functional magnetic resonance imaging (fMRI) and magnetoencephalography are new techniques of brain functional imaging which can provide the information of excitation of neurons by measure the changes of hemodynamics and electrophysiological data of local brain tissue. The purpose of this study was to study functional brain areas evoked by pure tones in healthy and sensorineural hearing loss subjects with these techniques and to compare the differences between the two groups.Methods Thirty healthy and 30 sensorineural hearing loss subjects were included in this study. In fMRI,block-design paradigm was used. During the active epoch the participants listened to 1000 Hz, sound pressure level 140 dB pure tones at duration 500 ms, interstimulus interval 1000 ms, which presented continuously via a magnetic resonance-compatible audio system. None stimulus was executed in control epoch. In magnetoencephalography study, every subject received stimuli of 1000 Hz tone bursts delivered to the bilateral ear at duration 8 ms, interstimulus intervals 1000 ms. Sound pressure level in healthy subjects was 30 dB; in sensorineural hearing loss subjects was 20 dB above everyone' s hearing threshold respectively. All subjects were examined with 306-channel whole-scalp neuromagnetometer.Results In fMRI, all subjects showed significant activations in bilateral Heschl's gyri, anterior pole of planum temporale, planum temporale, precentral gyri, postcentral gyri, supramarginal gyri, superior temporal gyri,inferior frontal gyri, occipital lobes and cerebellums. The healthy subjects had more intensive activation in bilateral Heschl's gyri, anterior pole of planum temporale, inferior frontal gyri, left superior temporal gyri and fight planum temporale than the hearing loss subjects. But in precentral gyri, postcentral gyri and occipital lobes,the activation is more intensive in the hearing loss subjects. In magnetoencephalography study, both in the

  1. [Efficacy of intratympanic steroid treatment for idiopathic sudden sensorineural hearing loss after failure of intravenous steroid treatment].

    Science.gov (United States)

    Kawano, Toshiro; Matsuura, Masaki; Ishitoya, Junichi; Oridate, Nobuhiko

    2014-06-01

    This study investigated the efficacy of intratympanic steroid (ITS) therapy as a salvage treatment for idiopathic sudden sensorineural hearing loss after failure of intravenous steroid (IVS) therapy. Systemic steroid therapy is the only standard drug therapy. However, ethically, we could not simply compare ITS with IVS. Conventionally, we have treated idiopahic sudden sensorineural hearing loss patients after failure of systemic steroid therapy with the double combined therapy IVS and hyperbaric oxygen (HBO), as the salvage modality. We examined the effect of ITS by adding it to the double combined therapy with IVS and HBO. Retrospectively, we clinically examined the effect of double combined therapy with IVS and HBO (A group) for 31 patients (12 men and 19 women) (median age: 54 years) with sudden hearing loss after failure of systemic steroid therapy between June, 2003 and July, 2010. Prospectively, we also examined clinically the effect of triple combined therapy with IVS and HBO, ITS (B group) for 29 patients (17 men and 12 women) (median age: 51 years) with sudden hearing loss after failure of systemic steroid therapy between August, 2010 and April, 2012. In the examination of patients treated within 30 days from the onset, one patient (3.2%) demonstrated remarkable recovery, 6 patients (19.4%) demonstrated mild recovery, while no change was noted in 24 patients (77.4%) in the A group. In the B group, 5 patients (17.2%) demonstrated complete recovery, 3 patients (10.3%) demonstrated remarkable recovery, mild recovery was seen in 14 patients (48.3%), and the remaining 7 patients (24.1%) showed no change. There was a significant difference (p hearing improvement in group B in five pure tone average was significantly better than in the group A (p hearing improvement than the A group. Therefore, ITS could be effective for idiopathic sudden sensorineural hearing loss patients after failure of systemic steroid therapy.

  2. Comparison of two different steroid treatments with hyperbaric oxygen for idiopathic sudden sensorineural hearing loss.

    Science.gov (United States)

    Sevil, Ergun; Bercin, Sami; Muderris, Togay; Gul, Fatih; Kiris, Muzaffer

    2016-09-01

    The purpose of the study was to assess the efficacy of the association of intratympanic (IT) steroid and hyperbaric oxygen (HBO) therapy in patients presenting with idiopathic sudden sensorineural hearing loss (ISSNHL), and to compare this protocol with another consisting of intravenous (IV) steroid administration and HBO therapy. A total of 80 patients diagnosed with ISSNHL were included in this prospective trial. Patients were divided into three categories: a mild-to-moderate ISSNHL group with a pure-tone average (PTA) ≤60 decibels (dB), a severe ISSNHL group with a PTA of 60-80 dB, and a profound ISSNHL group with a PTA ≥81 dB. The first protocol consisted of 20 sessions of HBO therapy together with IV methylprednisolone 1 mg/kg body weight and a 10 mg taper every 3 days for 10 days. The second protocol consisted of HBO therapy for 20 sessions, together with an IT injection of dexamethasone at a dose of 4 mg/mL, 0.5-0.7 mL once a day for 7 consecutive days, performed 3 h before the HBO therapy. In the mild-to-moderate ISSNHL patients, the mean hearing gain and successful treatment rate was 19 (0-27) dB and 78.9 %, respectively in the IT + HBO treatment group, and 18 (3-44) dB and 70.5 % in the IV + HBO therapy group. In the severe ISSNHL patients, the mean hearing gain and successful treatment rate was 33 (1-54) dB and 81.8 %, respectively in the IT + HBO treatment group and 33.5 (7-57) dB and 58.2 % in the IV + HBO group. In the profound ISSNHL patients, the mean hearing gain and successful treatment rate was 36 (4-69) dB and 40 %, respectively in the IT + HBO therapy group, and 39.5 (0-92) dB and 72.7 % in the IV + HBO treatment group. The results demonstrated that patients with severe hearing loss success rate was superior in the group submitted to IT + HBO treatment, conversely IV + HBO therapy may be benefit for patients with profound hearing loss. Nevertheless, these clinical results were not statistically significant.

  3. Intratympanic dexamethasone injection vs methylprednisolone for the treatment of refractory sudden sensorineural hearing loss

    Science.gov (United States)

    Berjis, Nezamoddin; Soheilipour, Saeed; Musavi, Alireza; Hashemi, Seyed Mostafa

    2016-01-01

    Background: During the past years various drugs have been used for sudden sensorineural hearing loss (SSNHL) treatment including steroids that are shown to be beneficial. Directed delivery of high doses of steroids into the inner ear is suggested for its potential and known as intratympanic steroids therapy (IST). Despite the use of dexamethasone and methylprednisolone as the traditional treatments, there are still debates about the optimal dosage, preferred drug, and the route of administration. Materials and Methods: We performed a randomized clinical trial study in which 50 patients suffering from SSNHL and resistant to standard therapy were employed. Each patient took 0.5 ml methylprednisolone (40 mg/mg) along with bicarbonate or dexamethasone (4 mg/mL) through direct intratympanic injection. This method was performed and scheduled once every 2 days for three times only for the dexamethasone receiving group. Hearing test was carried out and the results were analyzed according to a four-frequency (0.5, 1.0, 2.0, 3.0 kHz) pure tone average (PTA) and Siegel's criteria. Results: According to Siegel's criteria, three out of 25 (12%) dexamethasone receiving patients were healed in 1 and 4 (16%), 9 (32%) were respectively recovered in Siegel's criteria 2, 3, and 9 (32%) showed no recovery. In the group receiving methylprednisolone, recovery was found in 6 (24%), 8 (32%), 7 (28%) patients in the Siegel's criteria 1, 2, 3, respectively, and in 4 (16%) patients no recovery was recorded. In methylprednisolone group, hearing was significantly improved compared to the dexamethasone group (P therapies by Dexamethasone.

  4. Psychogenic hearing loss with panic anxiety attack after the onset of acute inner ear disorder.

    Science.gov (United States)

    Mori, Shigehito; Fujieda, Shigeharu; Yamamoto, Takehito; Takahashi, Noboru; Saito, Takehisa; Saito, Hitoshi

    2002-01-01

    A very rare case of a 50-year-old female showing psychogenic hearing loss with a panic anxiety attack that complicated an acute organic sensorineural hearing loss is reported. At the first visit to our clinic, the patient showed left sensorineural hearing loss with an inner ear disorder pattern. Five days after the onset, her left hearing threshold markedly increased without any subjective signs. On the next day, she suddenly experienced a severe panic attack with anxiety. After the attack, she felt mildly anxious and depressed. A combined therapy using primary corticosteroid therapy for the acute inner ear disorder, psychiatric counseling based on cognitive therapy and the administration of a minor tranquilizer was performed. Her left hearing threshold recovered to within normal ranges except in the high-frequency ranges immediately after the treatment. This case was considered very rare because: (1) the panic anxiety attack occurred in the conversion disorder as psychogenic hearing loss and (2) the psychogenic hearing loss complicated the primary sudden deafness. We suggest that otorhinolaryngologists should have psychiatric knowledge and be able to treat psychogenic hearing loss as a primary care. PMID:11891398

  5. Loudness of brief tones in listeners with normal hearing and sensorineural hearing loss

    DEFF Research Database (Denmark)

    Buus, Søren; Florentine, Mary; Poulsen, Torben

    1997-01-01

    To investigate how hearing loss affects the loudness of brief tones, loudness matches between 5- and 200-ms tones were obtained as a function of level. Loudness functions derived from these data indicated that the gain required to restore loudness usually is the same for short and long sounds....

  6. Otoacoustic Emissions in Sudden Sensorineural Hearing Loss: Changes of Measures with Treatment

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    Shadman Nemati

    2011-01-01

    Full Text Available Introduction: To identify changes in OAEs parameters in treatment course of idiopathic sudden sensorineural hearing loss (iSSNHL. Materials and Methods: In aprospective studyfromAugust 2005 to January 2009, 26 patients with iSSNHL underwent conventional audiometry/tympanometry and two types of OAEs (TEOAEs and DPOAEs before and after the completion of standard drug therapy.The changes in pre- and post- treatment parameters were compared with each other and with normal-contralateral ears. Results: In TEOAEs, the mean overall correlation (reproducibility and the mean overall strength in involved ears were 10.96±23.36 and 0.99±3.45 dB, respectively, before the treatment, which reached 22.88±36.55 and 1.85±5.3, respectively, after the treatment (P>0.05. Significant difference between “correlation score” (average of correlations at 3-4 involved frequencies before and after treatment was found: 6.52 ±18.19 vs. 21.67±37.8 (P

  7. Association of Chiari I malformation and cerebellar ectopia with sensorineural hearing loss.

    Science.gov (United States)

    Haktanir, Alpay; Yücedağ, Fatih; Kaçar, Emre; Ulu, Sahin; Gültekin, Mehmet Ali; Ünlü, Ebru; Bucak, Abdülkadir; Ayçiçek, Abdullah

    2013-07-01

    We aimed to examine the prevalence of cerebellar tonsil ectopia and Chiari 1 malformation in sensorineural hearing loss (SHL) that has, to the best of our knowledge, not been studied previously. Magnetic resonance imaging records of 166 subjects with SHL and 50 controls without known otologic disturbances were included in the study. A tonsils descent more than 2 mm was assumed as cerebellar ectopia, and a descent equal to or more than 5 mm was assumed as Chiari 1 malformation. A tonsil descent group was also formed by summation of both groups. Transverse diameters of bilateral intracranial vertebral arteries and transverse sinuses were also measured, and all parameters were analyzed using appropriate statistics. A significant difference of frequencies of Chiari 1, ectopia, and tonsil descent was detected between patients and controls. In comparison of cerebellar ectopia and Chiari 1 groups, SHL did not show any significant difference. The left lateral sinus diameter showed positive correlation with tonsil descent. There was no significant correlation for the diameters of other vessels. A powerful correlation was detected between SHL and age. In addition, right and vertebral artery diameters showed positive correlations with age. Chiari 1 malformation and cerebellar ectopia showed an association with SHL. These patients should also be evaluated for otologic disturbances. Further high-resolution magnetic resonance imaging studies to explain the exact cause of this currently unknown association seems required.

  8. The value of TORCH screening in children with bilateral profound sensorineural hearing loss

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    Rabee M Al Sabellha

    2012-01-01

    Full Text Available We aimed to ascertain the effectiveness of TORCH (toxoplasma, rubella, cytomegalovirus, herpes simplex investigation in children with profound sensorineural hearing loss (SNHL. Review of TORCH laboratory results in 2011 from 168 patients who had cochlear implants between 2006 and 2010 at King Abdul-Aziz University hospital Riyadh was conducted. Of the 168 patients, 102 had TORCH laboratory results. Nine were positive for cytomegalovirus (CMV IgM antibody (8.8%, two were positive for herpes simplex virus (HSV IgM antibody (1.96%, and one was positive for rubella IgG (0.9%. No patient showed positive results for toxoplasma or syphilis. The mean age at which the request was made was 5.89 years. All 102 patients who had TORCH laboratory results were above the age of 2 years, and all the patients had bilateral profound SNHL. The nine patients who were positive for CMV were above 1 year old, and it was thus difficult to differentiate between congenital and acquired CMV infection; however, acquired CMV is unlikely to cause a neurodevelopmental disability.

  9. Abnormal Magnetic Resonance Imaging Findings in Patients With Sudden Sensorineural Hearing Loss

    Science.gov (United States)

    Jeong, Kyung-Hwa; Choi, Jin Woo; Shin, Jung Eun; Kim, Chang-Hee

    2016-01-01

    Abstract The etiology of sudden sensorineural hearing loss (SSNHL) remains unclear in most cases. This study aimed to assess abnormal magnetic resonance imaging (MRI) findings in patients with SSNHL and evaluate the value of MRI in identifying the cause of SSNHL. A retrospective analysis of the charts and MRI findings of 291 patients with SSNHL was performed. In 291 patients, MRI abnormality, which was considered a cause of SSNHL, was detected in 13 patients. Vestibular schwannoma involving the internal auditory canal (IAC) and/or cerebellopontine angle was observed in 9 patients. All 9 patients had intrameatal tumors, and 6 of the 9 patients displayed extrameatal extension of their tumors. The tumor was small (<1 cm) or medium-sized (1.1–2.9 cm) in these 6 patients. Intralabyrinthine schwannoma, labyrinthine hemorrhage, IAC metastasis, and a ruptured dermoid cyst were each observed in 1 patient. The most commonly observed MRI abnormality in patients with SSNHL was vestibular schwannoma, and all of the lesions were small or medium-sized tumors involving the IAC. PMID:27124066

  10. Prolonged use of pancuronium bromide and sensorineural hearing loss in childhood survivors of congenital diaphragmatic hernia.

    Science.gov (United States)

    Cheung, P Y; Tyebkhan, J M; Peliowski, A; Ainsworth, W; Robertson, C M

    1999-08-01

    Sensorineural hearing loss (SNHL) is a significant neurologic morbidity in survivors of neonatal congenital diaphragmatic hernia (CDH), with a reported incidence of up to 60%. In a historical cohort study of 37 neonates with CDH, we investigated the use of pancuronium bromide (PB) and common ototoxic drugs during the neonatal period and their relationship to SNHL in childhood survivors. Survivors with SNHL (n = 23) had significantly higher cumulative dose of PB administered during the neonatal illness than survivors without SNHL (n = 14). The cumulative dose and duration of PB use significantly correlated (r = 0.66-0.81) and independently predicted (adjusted r (2) = 0.42-0.64) the greatest intensity (in decibels) and the widest band (lowest frequency in hertz) loss of SNHL. No differences were identified between survivors with and without SNHL regarding demographic and neonatal characteristics (including oxygenation and ventilation variables and the cumulative dose and duration of therapy with aminoglycosides, vancomycin, and furosemide), although survivors with SNHL had received a modestly higher cumulative dose of ethacrynic acid than survivors without SNHL. Although we show that prolonged administration of PB during the neonatal period is associated with SNHL in childhood survivors of CDH, further multicenter studies are required to investigate the possible etiologies of SNHL in this high-risk population.

  11. Two new cases with microdeletion of 17q23.2 suggest presence of a candidate gene for sensorineural hearing loss within this region

    DEFF Research Database (Denmark)

    Schönewolf-Greulich, Bitten; Ronan, Anne; Ravn, Kristine;

    2011-01-01

    . In this report, we describe two new 17q23.2 deletion patients with mild intellectual disability and sensorineural hearing loss. They both had submicroscopic deletions smaller than the common deleted region for the 8 previously described 17q23.2 microdeletion cases. TBX4 was previously suggested...... as the responsible gene for the heart or limb defects observed in 17q23.2 deletion patients, but the present cases do not have these features despite deletion of this gene. The finding of sensorineural hearing loss in 5 of the 10 cases, including the present cases, with a microdeletion at17q23.2, strongly suggests...... the presence of a candidate gene for hearing loss within this region. We screened 41 patients with profound sensorineural hearing loss for mutations of TBX2 and detected no mutations....

  12. Sudden Sensorineural Hearing Loss and Polymorphisms in Iron Homeostasis Genes: New Insights from a Case-Control Study

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    Alessandro Castiglione

    2015-01-01

    Full Text Available Background. Even if various pathophysiological events have been proposed as explanations, the putative cause of sudden hearing loss remains unclear. Objectives. To investigate and to reveal associations (if any between the main iron-related gene variants and idiopathic sudden sensorineural hearing loss. Study Design. Case-control study. Materials and Methods. A total of 200 sudden sensorineural hearing loss patients (median age 63.65 years; range 10–92 were compared with 400 healthy control subjects. The following genetic variants were investigated: the polymorphism c.−8CG in the promoter of the ferroportin gene (FPN1; SLC40A1, the two isoforms C1 and C2 (p.P570S of the transferrin protein (TF, the amino acidic substitutions p.H63D and p.C282Y in the hereditary hemochromatosis protein (HFE, and the polymorphism c.–582AG in the promoter of the HEPC gene, which encodes the protein hepcidin (HAMP. Results. The homozygous genotype c.−8GG of the SLC40A1 gene revealed an OR for ISSNHL risk of 4.27 (CI 95%, 2.65–6.89; P=0.001, being overrepresented among cases. Conclusions. Our study indicates that the homozygous genotype FPN1 −8GG was significantly associated with increased risk of developing sudden hearing loss. These findings suggest new research should be conducted in the field of iron homeostasis in the inner ear.

  13. Comparison of simultaneous systemic steroid and hyperbaric oxygen treatment versus only steroid in idiopathic sudden sensorineural hearing loss.

    Science.gov (United States)

    Ersoy Callioglu, Elif; Tuzuner, Arzu; Demirci, Sule; Cengiz, Ceyhun; Caylan, Refik

    2015-01-01

    A retrospective chart review to assess the effectiveness of hyperbaric oxygen treatment in sudden sensorineural hearing loss. 44 patients aged between 17-67 years diagnosed with idiopathic sensorineural hearing loss less than 30 days were admitted to our clinic Patients were treated with systemic steroid alone or systemic steroid plus hyperbaric oxygen therapy. In the comparison of two groups, there was no statistically significant difference of audiometric evaluation (P>0.0028) found in hearing improvement for each frequency on 5th day of the treatment and post treatment. Age (≤45 and >45) and initial hearing level (≤60 dB. And >60 dB.) does not seem to be an influential factor according to the results of the study (P>0.0007). The present study did not show more superior healing effect of hyperbaric oxygen therapy added to systemic steroid therapy than steroid infusion alone. The results are consistent with those of some papers. However there are also conflicting data that support significant effect of hyperbaric oxygen therapy. Routine administration of this therapy seems to be unnecessary in view of these results.

  14. [Effect of cochlear implantation on sound localization for patients with unilateral sensorineural hearing loss].

    Science.gov (United States)

    Liu, J F; Dai, J S; Wang, N Y

    2016-08-01

    The aim of this review was to examine the current literature regarding application of cochlear implantation on patients with unilateral sensorineural hearing loss (USNHL) for improvement on sound localization. The literature were searched in the PubMed database with 'cochlear implantation AND single-sided deafness' or 'cochlear implantation AND unilateral deafness' as keywords. The publication date of the articles was up to 2015-2-12. A total of 12 articles were included. The results show that the ability of sound localization for most of the USNHL subjects (90%) with cochlear implantation was significantly improved than that without CI, which suggests that CI is a superior auditory rehabilitation treatment than BAHA and CROS hearing aids for patients with USNHL, because of the re-establishment of the benefits of binaural hearing. In addition, the benefit of CI for USNHL requires a period of auditory experience or training. About 30% subjects showed significantly improvement on sound localization ability after CI worked for three months. For most of the patients (90%), the sound localization ability improved after CI worked for six months. When CI worked for nine months, all the subjects would show improvement on sound localization ability. Sound localization of the USNHL subjects with a CI is based primarily on interaural level differences (ILD) while interaural time differences (ITD) provide little advantage or probably not perceptible at all. The younger subject suffers from USNHL, the stronger the plasticity of the auditory center shows, which results in more obvious degeneration of the affected side and adaptive enhancement of the contralateral side of the auditory pathway. Similarly, the longer duration of USNHL lead to more obvious degeneration of the affected side and adaptive enhancement of the contralateral side. An adaptive enhancement of auditory pathway corresponding to the healthy ear will rely more on the monaural spatial cues that available to the

  15. Association between sudden sensorineural hearing loss and anxiety disorder: a population-based study.

    Science.gov (United States)

    Chung, Shiu-Dong; Hung, Shih-Han; Lin, Herng-Ching; Sheu, Jau-Jiuan

    2015-10-01

    Anxiety disorder (AD) is commonly associated with a number of physical illnesses. No previous study has investigated the association between AD and sudden sensorineural hearing loss (SSNHL). In this study, we investigated the association between prior AD and SSNHL using a population-based dataset in Taiwan. Sampled subjects of this case-control study were retrieved from the Taiwan "Longitudinal Health Insurance Database". We identified 3,522 patients who had a diagnosis of SSNHL as cases and 10,566 age- and gender-matched subjects without SSNHL as controls. A conditional logistic regression was used to calculate the odds ratio (OR) for having previously been diagnosed with AD between cases and controls. We found that of 14,088 patients, 13.4% had a prior AD diagnosis, 17.8 and 11.9% for the SSNHL group and controls, respectively. After adjusting for patient socioeconomic characteristics and comorbid medical disorders, SSNHL patients were more likely to have prior AD than the controls (OR 1.49, 95% confidence interval (CI) 1.34-1.66, p < 0.001). Furthermore, we found that the significant relationship between SSNHL and prior AD decreased with age. The relationship was the most pronounced among those aged ≤44 years, with an adjusted OR of 1.86 (95% CI 1.48-2.33, p < 0.001) for cases compared to controls. We concluded that patients with SSNHL had a higher proportion of prior AD than non-SSNHL-diagnosed controls. Further study is needed to confirm our findings and explore the underlying pathomechanisms.

  16. Sudden sensorineural hearing loss in adults: Our experience with multidrug high dose steroid regimen at tertiary care hospital

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    Vivek Gupta

    2016-01-01

    Full Text Available Introduction: Sudden sensorineural hearing loss is a confusing and controversial issue in our practice since no standard definition, evaluation method and treatment protocol exists. It is an otological emergency with narrow golden period of treatment. Objective: To establish the early diagnosis, treatment and study the outcome of treatment. Design and Method: In a prospective study, including patients >18 year age who had presented with sudden sensorineural hearing loss in ENT opd; after ENT examination, PTA, impedance audiometry and necessary imaging, were treated with i.v. methylprednisolone and inj.methylcobalamine i.m. along with tablet Pentoxyfylline and tablet prednisolone. PTA was repeated on 4th day, 3 week, and 6 weeks after diagnosis. Results: Total 37 patients were diagnosed and treated. Majority of patients had sudden SNHL of <72 hrs. duration with severe hearing loss and tinnitus as commonest associated symptom. Idiopathic cause was commonest followed by acoustic trauma and head trauma. 35.14% patients had complete recovery while 40.54% and 24.32% patients had partial and no recovery respectively. Conclusion: PTA is single most important investigation. Prompt treatment in <72 hrs. carry good prognosis. Associated vertigo, flat audiogram, DM, HTN are of poor prognosis.

  17. Lipid profiles and obesity as potential risk factors of sudden sensorineural hearing loss.

    Directory of Open Access Journals (Sweden)

    Joong Seob Lee

    Full Text Available The objective of our study was to establish whether increased lipid profiles and obesity affect the prevalence and prognosis of sudden sensorineural hearing loss (SSNHL.This was a case-controlled study with a longitudinal design. According to our criteria, 324 patients with SSNHL were included in this study. To manage potential covariates, 972 subjects with normal hearing from the Korean National Health and Nutrition Examination Survey were matched as control group according to their propensity scores. Age, level of total cholesterol (TC, high density lipoprotein cholesterol (HDL-C, low-density lipoprotein cholesterol (LDL-C, triglycerides (TG, and body mass index (BMI were obtained from the clinical data. Multivariate logistic regression analysis was used to investigate the association between SSNHL and lipid profiles or obesity in the 1296 subjects. Multivariate Cox regression analysis was used to determine whether lipid profiles and obesity are prognostic factors in patients with SSNHL.Mean body weight, BMI, TC, and TG were significantly higher in patients with SSNHL compared with control subjects (p<0.05. However, LDL-C values did not differ significantly between the two groups. Subjects with elevated TC and TG levels had a 2.20- (95% CI 1.50-3.24 and 1.50-fold (95% CI 1.08-2.08 increased odds, respectively, of SSNHL compared with subjects with normal TC and TG levels. Subjects with grade III BMI had a 1.59-fold (95% CI 1.17-2.16 increased odds of SSNHL. Multivariate Cox regression analyses revealed that BMI was an independent risk factor of treatment outcome, as patients with BMI ≥27.5 were less likely to achieve complete recovery than those with BMI <27.5 (p<0.05.The results of this study revealed that elevated TC and TG levels and increased BMI are significantly associated with the prevalence of SSNHL and its prognosis, indicating that vascular compromise may play an important role in the pathogenesis of SSNHL.

  18. Sensorineural hearing loss and status epilepticus associated with ulcerative colitis: Is there enough evidence to support immune-related mechanisms?

    Directory of Open Access Journals (Sweden)

    Sinem Yazici

    2015-01-01

    Full Text Available Ulcerative colitis (UC is characterized by an inflammatory disorder of the gastrointestinal tract. Immune-mediated extraintestinal manifestations of UC have increasingly attracted attention in the literature recently, for which UC is now considered as a systemic disease. Neurologic involvement associated with UC is probably under-reported because of the unawareness of many physicians, although early recognition and treatment are crucial in preventing major morbidity and sequel. In this case report is presented a patient newly diagnosed as UC, who developed both sensorineural hearing loss and intractable status epilepticus that we suggest to have resulted from immune-mediated mechanisms.

  19. Evaluation of intratympanic dexamethasone for treatment of refractory sudden sensorineural hearing loss

    Institute of Scientific and Technical Information of China (English)

    Yao-wen WANG; Ji-hao REN; Yong-de LU; Tuan-fang YIN; Ding-hua XIE

    2012-01-01

    Objective:To observe and compare the efficacy of intratympanic application of dexamethasone (DXM) for the treatment of refractory sudden sensorineural hearing loss (SSNHL),the DXM was given in three different ways:by tympanic membrane injection,by drip through a ventilation tube,and by perfusion through a round window catheter.Methods:We conducted a nonrandomized retrospective clinical trial involving 55 patients with refractory SSNHL.For 21 patients (the perfusion group),DXM (2.5 mg/0.5 ml) was perfused transtympanically through a round window catheter using an infusion pump for 1 h twice a day for 7 d giving a total amount of 35.0 mg.For 23 patients (the injection group),DXM (2.5 mg/time) was injected by tympanic membrane puncture at intervals of 2 d on a total of four occasions giving a total amount of 10.0 mg.For 11 patients (the drip group),DXM (2.5 mg/0.5 ml) was dripped via a ventilation tube placed by myringotomy,once on the first day and twice a day for the remaining 6 d giving a total amount of 32.5 mg.Thirty-two patients with refractory SSNHL who refused to undertake further treatments were defined as the control group.Hearing recovery and complications were compared among the groups.Hearing results were evaluated based on a four-frequency (0.5,1.0,2.0,4.0 kHz) pure tone average (PTA).Results:Post-treatment audiograms were obtained one month after treatments were completed.The improvements in average PTA for the perfusion,injection,and drip groups were 9.0,8.6,and 1.7 dB,respectively.Hearing improvement was significantly greater in the perfusion and injection groups than in the control group (1.4 dB) (P<0.05).In the perfusion group,8 out of 21 patients (38.1%) had a PTA improvement of 15-56 dB (mean 29.8 dB); in the injection group,8 out of 23 patients (34.8%) had a PTA improvement of 16-54 dB (mean 24.9 dB); in the drip group,1 of 11 patients (9.1%) had a PTA improvement of 26.0 dB; in the control group,3 out of 32 patients (9.4%) had a PTA

  20. A Comparison of Thresholds in Auditory Steady - State Response with Pure Tone Audiometry in Subjects with Normal Hearing and Those with Mild and Moderate Sensorineural Hearing los

    Directory of Open Access Journals (Sweden)

    Sadegh Jafarzadeh

    2008-06-01

    Full Text Available Background and Aim: Among all auditory assessment tools, auditory steady state response (ASSR is a modern test. Modulation frequency for this test is usually 80 Hz. The purpose of this study, was to examined adult subjects with 40 Hz and 80 Hz ASSR and compare the results.Materials and Methods: Thirty adult (60 ears were evaluated by ASSR and PTA test, Results were divided into three groups: normal hearing, mild and moderate sensorineural hearing loss. Results: In all groups, forty hertz ASSR thresholds were relatively closer to behavioral threshold than those of 80 Hz ASSR(p<0.05. Besides, the more severe hearing loss, the lower the difference between those two thresholds. Correlation coefficients were also higher in 40 Hz ASSR(p<0.05. Conclusion: Frequency modulation thresholds with 40 Hz are more likely to be closer to the behavioral thresholds. Moreover, it has better results than the thresholds with 80 Hz.

  1. 1H-MRS study of the auditory cortex in patients with severe sudden sensorineural hearing loss in acute and convalescent stages%重度突发性聋患者急性期与恢复期听皮层磁共振波谱分析

    Institute of Scientific and Technical Information of China (English)

    窦晓清; 陈贤明; 梁永辉; 张丽卫; 罗碧强; 邓意红

    2012-01-01

    目的 利用氢质子磁共振波谱(1H-MRS)技术,研究单侧重度突发性聋患者急性期与恢复过程中听皮层的代谢变化.方法 选取右耳重度突发性聋急性期患者15例(发病时间<1周),经过常规治疗3个月后恢复期患者9例,健康志愿者10例作为对照组.将全部受试者行磁共振波谱检测,测定双侧颞横回N-乙酰天门冬氨酸(NAA)、肌酸(cr)、胆碱(Cho)、γ-氨基丁酸(GABA)、谷氨酰胺及谷氨酸复合物(Glu)的峰下面积并计算NAA/Cr、Cho/Cr、GABA/Cr、Glu/Cr的比值.分析重度突聋急性期与3个月后双侧听皮层代谢差异.结果 与对照组相比,突聋急性期双侧NAA/Cr、双侧Cho/Cr,右侧GABA/Cr、右侧Glu/Cr比值无明显差异(P>0.05),而左侧听皮层GABA/Cr比值明显下降,Glu/Cr明显上升(P<0.05).突聋3个月组双侧NAA/Cr、右侧Cho/Cr、右侧GABA/Cr、右侧Glu/Cr比值无明显差异(P>0.05).左侧Cho/Cr比值稍下降,GABA/Cr比值略上升但仍低于对照组,Glu/Cr比值略下降但仍高于对照组(P<0.05).结论 磁共振波谱可以为人体活体听皮层代谢物浓度改变提供有价值的信息;突聋患者对侧听皮层GABA、G1u代谢异常,提示听觉中枢可能发生代谢改变、功能重组.%Objective To study the metabolic changes of the auditory cortex in the patients with unilateral severe sudden sensorineural hearing loss (SSNHL) in acute and convalescent stages by using proton magnetic resonance spec-(roscopy (1H-MRS). Methods 15 patients with acute severe SSNHL in right ear were studied (the onset time of severe sudden deafness 0.05). The GABA/Cr ratio was significantly lower in the left auditory cortex of severe SSNHL patients in the acute stage than that in the control group( P 0. 05). The Cho/Cr ratio was significantly lower in the left auditory cortex of severe SSNHL patients in the convalescent stage than that in the control group(P<0.05). The GABA/Cr ratio was slightly increased but still significantly

  2. The Treatment of Idiopathic Sudden Sensorineural Hearing Loss Using Phle-botomy: A Prospective, Randomized, Double-Blind Clinical Trial

    Directory of Open Access Journals (Sweden)

    Mohammad Taghi Goodarzi

    2009-12-01

    Full Text Available This randomized clinical trial aimed to assess the efficacy of phlebotomy on improvement of hearing loss. 71 patients with sudden sensorineural hearing loss were enrolled in this randomized clinical trial study. They were divided into two groups: group A received steroid and hydration therapy plus phlebotomy, while group B received the same regimen without phlebotomy. They were matched according to sex, age, Hb, and Htc. Pure tone audiometries were administered to examine the hearing levels before and after treatment. Statistical analysis showed higher improvement in 250-1000 Hz in patients whit phlebotomy (P<0.001. However, there was noticed no significant difference in hearing improvement in 2000-8000 Hz between two methods. The number (% of patients who had improvement was 29(85.3% in phlebotomy group and 21(56.8% in non-phlebotomy group. On the other hand, the number (% of patients who showed no improvement in A and B group was 5(14.7% and 16(43.2%, respectively (P=0.008. Using phlebotomy accompanied by steroid and hydration therapy leads to higher improvement in hearing loss especially in 250-1000 Hz. We think that this method has the ability to achieve better result in the management of patients with SSNHL.

  3. Ischemia as a potential etiologic factor in idiopathic unilateral sudden sensorineural hearing loss: Analysis of posterior circulation arteries.

    Science.gov (United States)

    Kim, Chulho; Sohn, Jong-Hee; Jang, Min Uk; Hong, Sung-Kwang; Lee, Joong-Seob; Kim, Hyung-Jong; Choi, Hui-Chul; Lee, Jun Ho

    2016-01-01

    The association between idiopathic sudden sensorineural hearing loss (ISSNHL) and the radiologic characteristics of the vertebrobasilar artery is unclear. We hypothesized that the degree and direction of vertebrobasilar artery curvature in the posterior circulation contribute to the occurrence of ISSNHL. We consecutively enrolled patients diagnosed with unilateral ISSNHL in two tertiary hospitals. Magnetic resonance images were performed in all patients to exclude specific causes of ISSNHL, such as vestibular schwannoma, chronic mastoiditis, and anterior inferior cerebellar artery infarct. We measured the following parameters of posterior circulation: vertebral and basilar artery diameter, the degree of basilar artery curvature (modified smoker criteria), and vertebral artery dominance. Pure tone audiometries were performed at admission and again 1 week and 3 months later. A total of 121 ISSNHL patients (mean age, 46.0 ± 17.3 years; 48.8% male) were included in these analyses. The proportion of patients with the left side hearing loss was larger than the proportion with the right side hearing loss (left, 57.9%; right, 42.1%). The majority of patients were characterized by a left dominant vertebral artery and right-sided basilar artery curvature. The direction of the basilar artery curvature was significantly associated with hearing loss lateralization (p = 0.036). Age and sex matched multivariable analyses revealed the absence of diabetes and right-sided basilar artery curvature as significant predictors for left sided hearing loss. There was no statistical difference between atherosclerotic cardiovascular risk score (high versus low) and hearing outcomes at 3 months. In ISSNHL, the laterality of hearing loss was inversely associated with the direction of basilar artery curvature. Our results, therefore, indicate the importance of vascular assessment when evaluating ISSNHL.

  4. Synaptopathy in the noise-exposed and aging cochlea: Primary neural degeneration in acquired sensorineural hearing loss.

    Science.gov (United States)

    Kujawa, Sharon G; Liberman, M Charles

    2015-12-01

    The classic view of sensorineural hearing loss (SNHL) is that the "primary" targets are hair cells, and that cochlear-nerve loss is "secondary" to hair cell degeneration. Our recent work in mouse and guinea pig has challenged that view. In noise-induced hearing loss, exposures causing only reversible threshold shifts (and no hair cell loss) nevertheless cause permanent loss of >50% of cochlear-nerve/hair-cell synapses. Similarly, in age-related hearing loss, degeneration of cochlear synapses precedes both hair cell loss and threshold elevation. This primary neural degeneration has remained hidden for three reasons: 1) the spiral ganglion cells, the cochlear neural elements commonly assessed in studies of SNHL, survive for years despite loss of synaptic connection with hair cells, 2) the synaptic terminals of cochlear nerve fibers are unmyelinated and difficult to see in the light microscope, and 3) the degeneration is selective for cochlear-nerve fibers with high thresholds. Although not required for threshold detection in quiet (e.g. threshold audiometry or auditory brainstem response threshold), these high-threshold fibers are critical for hearing in noisy environments. Our research suggests that 1) primary neural degeneration is an important contributor to the perceptual handicap in SNHL, and 2) in cases where the hair cells survive, neurotrophin therapies can elicit neurite outgrowth from spiral ganglion neurons and re-establishment of their peripheral synapses. This article is part of a Special Issue entitled .

  5. A comparison of effects of systemic and intratympanic steroid therapies for sudden sensorineural hearing loss:A meta-analysis

    Institute of Scientific and Technical Information of China (English)

    Dan Zhao; Busheng Tong; Qiang Wang; Sten Hellstrom; Maoli Duan

    2016-01-01

    Objective:To evaluate the efficacy and safety of intratympanic and systemic steroid therapies in the initial treatment of Sudden Sensorineural Hearing Loss (SSNHL) patients. Methods:A comprehensive search of PubMed, Wanfang database and CNKI (China National Knowledge Infrastructure) was performed covering the period from January 1990 to July 2014. A meta-analysis was conducted after filtering by the criteria of Cochrane Collaboration. Three hundred fifty six subjects in nine studies allocated to the group of intratympanic steroid therapies and 343 controls receiving systemic steroid therapies met the criteria for meta-analysis. The data were extracted and analyzed using the RevMan 5.3 meta-analysis software. Results: The total effectiveness rate in SSNHL patients receiving intratympanic steroid therapies did not differ statistically from patients receiving systemic therapies (RR ¼ 1.08, 95%CI ¼ 0.99e1.99, P ¼ 0.10), although the rate of full hearing recovery in this group differed significantly from patients receiving systemic therapies (RR ¼ 1.29, 95%CI ¼ 1.00e1.66, P ¼ 0.05). Conclusion: Local steroid therapy appears to generate higher rate of complete hearing recovery than systemic steroid treatment as an initial treatment for SSNHL, which may be especially useful for patients in whom systemic steroids are contraindicated.

  6. The efficiency of intratympanic dexamethasone injection as a sequential treatment after initial systemic steroid therapy for sudden sensorineural hearing loss.

    Science.gov (United States)

    Lee, Jong Bin; Choi, Seong Jun; Park, Keehyun; Park, Hun Yi; Choo, Oak-Sung; Choung, Yun-Hoon

    2011-06-01

    The effect of intratympanic steroid injection is controversial as salvage or initial treatment option for sudden sensorineural hearing loss (SSNHL) and almost unknown if it is consecutively to use after initial systemic steroids. This study aimed to analyze the efficiency of intratympanic dexamethasone injection (ITDI) as a sequential treatment in the patients who failed initial systemic steroid treatments for SSNHL. Forty-six patients with SSNHL who did not respond to initial systemic steroids were prospectively included in the study. The patients were randomly classified into two groups; the ITDI group (21 patients) did not take four sequential ITDI within 2 weeks after systemic steroids, and the control group (25 patients) took any more medications. Hearing improvement was defined as a 10 dB or more decrease in the pure tone average (PTA) of the four-frequencies (0.5, 1, 2, and 3 kHz). Hearing improvement was observed in 10 (47.6%) of 21 ITDI patients and in 4 (16.0%) of 25 control patients (P = 0.027). An improvement of the mean PTA was 11.4 dB in the ITDI group and 1.7 dB in the control group (P = 0.004). The ITDI group showed significant hearing improvement at low frequency (500 Hz) than the control group. The patients with 70 or more dB in PTA before ITDI showed significant hearing improvement than the other patients with better PTAs (P = 0.038). The sequential ITDI, which is performed immediately after initial systemic steroid therapy, may be a simple, effective second-line treatment of choice for the patients who show poor response to initial treatments for SSNHL.

  7. Analyses prognostic factors relevant to sudden sensorineural hearing loss%突发性聋预后相关因素分析

    Institute of Scientific and Technical Information of China (English)

    王军; 肖水芳; 曾镇罡; 甄甄; 张雪溪; 林枫; 董明敏; 卢伟; 秦兆冰

    2015-01-01

    standardized clinical research methods,unified design,and unified program were adopted to conduct the prospective clinical multi-center study.The sudden deafness patients between 18 to 65 years old,with the course of this disorder less than two weeks,and without any medical treatments were collected,and then,divided into four types according to the hearing curve:type A,acute sensorineural hearing loss in low tone frequencies;type B,acute sensorineural hearing loss in high tone frequencies;type C,acute sensorineural hearing loss in all frequencies;and type D,total deafness.The factors,in terms of age,gender,type of initial audiogram,time delay before the first visit,and severity of hearing loss,were included in the analyses.Results A total of 1 024 cases with single side sudden deafness were collected in the study from 33 hospitals in China from August 2007 to October 2011,inclusive of for 492 males (48.05%) and 532 females (51.95%).The average age was (41.2 ± 12.8) years old.There were 553 cases(54.00%) in left ear,and 471 cases(46.00%) in right ear.The curative effects of different types were shown as follows:the type in low tone frequencies had the highest rate of 90.73%,the type in all frequencies was 82.59%;the type of total deafness was 70.29%;and the type in high tone frequencies had the lowest rate of 65.96%.It had significant difference of the effective rate between different types (x2 =231.58,P =0.000).Age,time delay before first visit,and severity of initial hearing loss were significantly correlated with hearing improvement.Conclusions Initial audiogram of SSNHL might predict hearing recovery.The young in age and a short time delay before starting treatment are positive prognostic factors for hearing recovery in SSNHL.The initial severity of hearing loss is negative prognostic factor of hearing recovery.

  8. Intronic variants in the NFKB1 gene may influence hearing forecast in patients with unilateral sensorineural hearing loss in Meniere's disease.

    Science.gov (United States)

    Cabrera, Sonia; Sanchez, Elena; Requena, Teresa; Martinez-Bueno, Manuel; Benitez, Jesus; Perez, Nicolas; Trinidad, Gabriel; Soto-Varela, Andrés; Santos-Perez, Sofía; Martin-Sanz, Eduardo; Fraile, Jesus; Perez, Paz; Alarcon-Riquelme, Marta E; Batuecas, Angel; Espinosa-Sanchez, Juan M; Aran, Ismael; Lopez-Escamez, Jose A

    2014-01-01

    Meniere's disease is an episodic vestibular syndrome associated with sensorineural hearing loss (SNHL) and tinnitus. Patients with MD have an elevated prevalence of several autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis and psoriasis), which suggests a shared autoimmune background. Functional variants of several genes involved in the NF-κB pathway, such as REL, TNFAIP3, NFKB1 and TNIP1, have been associated with two or more immune-mediated diseases and allelic variations in the TLR10 gene may influence bilateral affectation and clinical course in MD. We have genotyped 716 cases of MD and 1628 controls by using the ImmunoChip, a high-density genotyping array containing 186 autoimmune loci, to explore the association of immune system related-loci with sporadic MD. Although no single nucleotide polymorphism (SNP) reached a genome-wide significant association (phearing loss progression in patients with unilateral SNHL. So, individuals with unilateral MD carrying the C allele in rs3774937 or G allele in rs4648011 had a shorter mean time to reach hearing stage 3 (>40 dB HL) (log-rank test, corrected p values were p = 0.009 for rs3774937 and p = 0.003 for rs4648011, respectively). No variants influenced hearing in bilateral MD. Our data support that the allelic variants rs3774937 and rs4648011 can modify hearing outcome in patients with MD and unilateral SNHL.

  9. Genotype-phenotype correlation for DFNA22: characterization of non-syndromic, autosomal dominant, progressive sensorineural hearing loss due to MYO6 mutations

    DEFF Research Database (Denmark)

    Tranebjærg, Lisbeth; Rendtorff, Nanna D; Topsakal, Vedat;

    2010-01-01

    Clinical and audiological examination was done in 2 Belgian families with autosomal dominant sensorineural hearing loss (SNHL) linked to DFNA22. Nineteen subjects in family 1 had mild to moderate SNHL starting in the third decade. The hearing loss was characterized by a flat audiogram affecting all...... tested frequencies with statistically significant progression. In family 2 eleven subjects were affected with mild to moderate SNHL starting in the second decade. Most of them showed a flat audiogram, but some had mid-frequency hearing loss. Significant progression of thresholds was present at 4 and 8 k...

  10. The relationship between serum lipids and sudden sensorineural hearing loss: a systematic review and meta-analysis.

    Directory of Open Access Journals (Sweden)

    I Jen Chang

    Full Text Available Sudden sensorineural hearing loss (SSNHL is a relatively common condition that is usually of unknown etiology. A number of individual studies have investigated the association between various serum lipids and SSNHL; however, the findings have been inconsistent. In an attempt to obtain more definitive information on the relationship between serum lipids and SSNHL, we carried out a systematic review and meta-analysis.Medline, the Cochrane Library, and EMBASE were searched using the following key words: lipid, cholesterol, triglyceride, fat, serum, blood, sudden hearing loss, hearing loss, hearing disorders. Randomized controlled trials, prospective cohort studies, and retrospective case-control studies involving patients with SSNHL and healthy controls that examined the relationship (reported as odds ratios [OR] between lipid profiles and SSNHL were included. Primary outcomes were total cholesterol and low-density lipoprotein cholesterol (LDL-C concentrations. Secondary outcomes were triglyceride, high-density lipoprotein cholesterol, and lipoprotein(a concentrations.A total of 6 case-control studies were included in this systematic review/meta-analysis. The total number of participants ranged from 30 to 250 in the case group and from 43 to 271 in the control group. Meta-analysis revealed no significant difference in total cholesterol levels between the case and control groups (pooled OR = 1.79, 95% confidence interval [CI] = 0.98 to 3.26, P = 0.057. Likewise, meta-analysis revealed no significant difference in LDL-C concentrations between the case and control groups (pooled OR = 1.15, 95% CI = 0.64 to 2.07, P = 0.639. Since there were an insufficient number of studies reporting data for the secondary outcomes, meta-analysis was not possible.Our results do not provide evidence for serum lipids being associated with SSNHL, nor do they definitively rule out such an association. Additional studies are needed to ascertain the relationship, or lack

  11. Intronic variants in the NFKB1 gene may influence hearing forecast in patients with unilateral sensorineural hearing loss in Meniere's disease.

    Directory of Open Access Journals (Sweden)

    Sonia Cabrera

    Full Text Available Meniere's disease is an episodic vestibular syndrome associated with sensorineural hearing loss (SNHL and tinnitus. Patients with MD have an elevated prevalence of several autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis and psoriasis, which suggests a shared autoimmune background. Functional variants of several genes involved in the NF-κB pathway, such as REL, TNFAIP3, NFKB1 and TNIP1, have been associated with two or more immune-mediated diseases and allelic variations in the TLR10 gene may influence bilateral affectation and clinical course in MD. We have genotyped 716 cases of MD and 1628 controls by using the ImmunoChip, a high-density genotyping array containing 186 autoimmune loci, to explore the association of immune system related-loci with sporadic MD. Although no single nucleotide polymorphism (SNP reached a genome-wide significant association (p40 dB HL (log-rank test, corrected p values were p = 0.009 for rs3774937 and p = 0.003 for rs4648011, respectively. No variants influenced hearing in bilateral MD. Our data support that the allelic variants rs3774937 and rs4648011 can modify hearing outcome in patients with MD and unilateral SNHL.

  12. Mitochondrial DNA variant m.15218A > G in Finnish epilepsy patients who have maternal relatives with epilepsy, sensorineural hearing impairment or diabetes mellitus

    OpenAIRE

    Soini, Heidi K; Moilanen, Jukka S; Vilmi-Kerälä, Tiina; Finnilä, Saara; Majamaa, Kari

    2013-01-01

    Background Mitochondrial diseases caused by mutations in mitochondrial DNA (mtDNA) affect tissues with high energy demand. Epilepsy is one of the manifestations of mitochondrial dysfunction when the brain is affected. We have studied here 79 Finnish patients with epilepsy and who have maternal first- or second-degree relatives with epilepsy, sensorineural hearing impairment or diabetes mellitus. Methods The entire mtDNA was studied by using conformation sensitive gel electrophoresis and PCR f...

  13. Association of the 4 g/5 g polymorphism of plasminogen activator inhibitor-1 gene with sudden sensorineural hearing loss. A case control study

    OpenAIRE

    Cho Seong; Chen Haimei; Kim Il; Yokose Chio; Kang Joseph; Cho David; Cai Chun; Palma Silvia; Busi Micol; Martini Alessandro; Yoo Tae J

    2012-01-01

    Abstract Background The 5 G/5 G genotype of PAI-1 polymorphism is linked to decreased plasminogen activator inhibitor-1 (PAI-1) levels and it has been suggested that lower PAI-1 levels may provide protective effects on inflammation, local microcirculatory disturbance, and fibrotic changes, which are likely associated with development of sudden sensorineural hearing loss (SSNHL). Methods The association of the 4 G/5 G PAI-1 polymorphism with the development and clinical outcome of SSNHL is eva...

  14. Changes of the directional brain networks related with brain plasticity in patients with long-term unilateral sensorineural hearing loss.

    Science.gov (United States)

    Zhang, G-Y; Yang, M; Liu, B; Huang, Z-C; Li, J; Chen, J-Y; Chen, H; Zhang, P-P; Liu, L-J; Wang, J; Teng, G-J

    2016-01-28

    Previous studies often report that early auditory deprivation or congenital deafness contributes to cross-modal reorganization in the auditory-deprived cortex, and this cross-modal reorganization limits clinical benefit from cochlear prosthetics. However, there are inconsistencies among study results on cortical reorganization in those subjects with long-term unilateral sensorineural hearing loss (USNHL). It is also unclear whether there exists a similar cross-modal plasticity of the auditory cortex for acquired monaural deafness and early or congenital deafness. To address this issue, we constructed the directional brain functional networks based on entropy connectivity of resting-state functional MRI and researched changes of the networks. Thirty-four long-term USNHL individuals and seventeen normally hearing individuals participated in the test, and all USNHL patients had acquired deafness. We found that certain brain regions of the sensorimotor and visual networks presented enhanced synchronous output entropy connectivity with the left primary auditory cortex in the left long-term USNHL individuals as compared with normally hearing individuals. Especially, the left USNHL showed more significant changes of entropy connectivity than the right USNHL. No significant plastic changes were observed in the right USNHL. Our results indicate that the left primary auditory cortex (non-auditory-deprived cortex) in patients with left USNHL has been reorganized by visual and sensorimotor modalities through cross-modal plasticity. Furthermore, the cross-modal reorganization also alters the directional brain functional networks. The auditory deprivation from the left or right side generates different influences on the human brain. PMID:26621123

  15. Development of the stria vascularis and potassium regulation in the human fetal cochlea: Insights into hereditary sensorineural hearing loss.

    Science.gov (United States)

    Locher, Heiko; de Groot, John C M J; van Iperen, Liesbeth; Huisman, Margriet A; Frijns, Johan H M; Chuva de Sousa Lopes, Susana M

    2015-11-01

    Sensorineural hearing loss (SNHL) is one of the most common congenital disorders in humans, afflicting one in every thousand newborns. The majority is of heritable origin and can be divided in syndromic and nonsyndromic forms. Knowledge of the expression profile of affected genes in the human fetal cochlea is limited, and as many of the gene mutations causing SNHL likely affect the stria vascularis or cochlear potassium homeostasis (both essential to hearing), a better insight into the embryological development of this organ is needed to understand SNHL etiologies. We present an investigation on the development of the stria vascularis in the human fetal cochlea between 9 and 18 weeks of gestation (W9-W18) and show the cochlear expression dynamics of key potassium-regulating proteins. At W12, MITF+/SOX10+/KIT+ neural-crest-derived melanocytes migrated into the cochlea and penetrated the basement membrane of the lateral wall epithelium, developing into the intermediate cells of the stria vascularis. These melanocytes tightly integrated with Na+/K+-ATPase-positive marginal cells, which started to express KCNQ1 in their apical membrane at W16. At W18, KCNJ10 and gap junction proteins GJB2/CX26 and GJB6/CX30 were expressed in the cells in the outer sulcus, but not in the spiral ligament. Finally, we investigated GJA1/CX43 and GJE1/CX23 expression, and suggest that GJE1 presents a potential new SNHL associated locus. Our study helps to better understand human cochlear development, provides more insight into multiple forms of hereditary SNHL, and suggests that human hearing does not commence before the third trimester of pregnancy. PMID:25663387

  16. Sensorineural Hearing Affection In Sickle Cell Disease Patients With Chronic Renal Failure Under Dialysis

    Directory of Open Access Journals (Sweden)

    Saeed Abdelwhab Saeed MD*, Magdy M El Sharkawy

    2002-09-01

    Full Text Available Objective: to study the problem of hearing loss in patients of chronic renal failure on regular haemodialysis and The factors which affect it. And to study the effect of sickle cell disease on hearing loss. we studied hearing loss in dialysis patients, sickle cell disease patients and patients of sickle cell disease with chronic renal failure under dialysis compared to normal control subjects. Design: !"",include sickle cell disease patients with chronic renal fa"# $%& ' ", i ,nclude ( # #"# $%&'", , ,( #&'", i 9nclude the normal *+&*+' All groups are subjected to full history, thorough clinical examination including neurological and ENT examination, investigations includes Hb, s. creatinine, s.albumen, s.calcium and calculation of kt/v for dialysis patients. Full audiological assessment, using #,-GSI audiometer was done for all groups with special concentration at frequency of - .Results: hearing loss was found in patients with chronic renal failure more than normal control. Patient with sickle cell disease have hearing disorders significantly higher than $/%- .% 0( # #cell disease have significantly. Marked degree of SNHL than those with SCD only. Hearing loss in patients with 12( # * 3 &4 !4! '#"#"patients with chronic renal failure with or without SCD correlate with duration of dialysis , presence of peripheral neuropathy, s. calcium level, efficiency of dialysis marked by kt/v. Conclusion and recommendation: hearing disorder is common in patients with chronic renal failure under regular haemodialysis and it increase with duration of dialysis it should be suspected if there is Peripheral neuropathy. It can be reduced with efficient dialysis, correction of anemia, adjustment of calcium level. Patients with SCD suffer also some degree of hearing loss especially at higher frequency and this degree of hearing loss

  17. Otoacoustic emissions and auditory brainstem responses in patients with sudden sensorineural hearing loss. Do otoacoustic emissions have prognostic value?

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    Manoochehr Amiridavan

    2006-11-01

    Full Text Available BACKGROUND: Sudden sensorineural hearing loss (SSNHL is a perplexing condition for patients and there are many controversies about its etiology, audiologic characteristics, prognostic factors, and treatment. METHODS: In this prospective study, we performed some audiologic tests, including PTA, IA, ABR, and OAE (TEOAE before beginning treatment of 53 patients with SSNHL. We assigned the patients randomly to two treatment groups: oral steroids + acyclovir vs. intravenous urographin. Twenty-eight patients underwent Magnetic Resonance Imaging (MRI of the Brain. RESULTS: Of 53 patients (22 female and 31 male, 22 (41.5% had negative or no signal to noise ratio and overall correlation in TEOAE. Twenty-six patients (49% had positive overall correlations less than 50%, and 5 patients (4.4% had overall correlations >50%. Fifteen patients (28. 3% responded completely or well, 20 (37.7% responded partially, and 18 (33.9% had poor or no response to the treatment. The mean values for overall correlation in 3 subgroups of patients (no response, partial response, and complete response were – 3. 5% (+ 1/16%, +11% (+ 1/99%, and +36.6% (+3/07%, respectively (P = 0.01. Twenty out of 52 patients had no reproducible wave in ABR (38.5%, and waves I, III, and V were absent in 40 (77%, 31 (59.6% and 21 (40% patients, respectively. There were some limitations (false positive and false negative results in ABR use in our cases, but it may be useful in detecting site of lesion in SSNHL. Overall, according to the results of OAE, ABR, and brain MRI of these patients, 3 were affected by acoustic neurinomas, at least 1 had auditory neuropathy, and the site of lesion was cochlear in 6, and cochlear + retrocochlear in 13 patients. CONCLUSIONS: ABR has limitations for use in SSNHL and seems not to obviate the need for brain MRI, but may help in determining the site of lesions such as ischemia or neuropathy. Overall correlation (and S/N ratio in TEOAE is a valuable

  18. Surdez súbita idiopática: aspectos etiológicos e fisiopatogênicos Idiopathic sudden sensorineural hearing loss: etiopathogenic aspects

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    Paulo Roberto Lazarini

    2006-08-01

    Full Text Available Vários fatores têm sido postulados como causa da surdez súbita idiopática. Por meio de uma revisão bibliográfica foi feita uma análise crítica quanto aos aspectos etiológicos e fisiopatogênicos desta manifestação clínica. Estudos atuais sugerem que os distúrbios vasculares, a ruptura de membranas da orelha interna e as doenças auto-imunes são possíveis causas, mas a afecção viral tem recebido maior atenção nos últimos anos, embora ainda pouco se conheça sobre os mecanismos da surdez súbita idiopática. Os vírus podem causar a perda súbita da audição na infecção aguda, mas a forma latente, com uma possível reativação viral, também tem sido considerada no mecanismo de agressão à cóclea. Apesar de uma alteração da viscosidade sangüínea poder explicar a perda auditiva, estudos experimentais e clínicos não mostram sinais de ossificação e de fibrose na cóclea ou de ruptura de membranas do labirinto. Estes fatos contrapõem, respectivamente, a teoria vascular e a da fístula labiríntica. A eventual presença de anticorpos contra a orelha interna sugere que a surdez súbita idiopática possa ser de natureza auto-imune, fato este também não confirmado pela falta de relação entre os aspectos clínicos e morfológicos da doença auto-imune e da perda auditiva. A surdez súbita idiopática é, ainda, um tema controverso e obscuro em diversos aspectos.Several factors have been postulated to elicit the etiology of idiopathic sudden sensorineural hearing loss. Through a bibliographic review, we made a critical analysis of the different etiopathogenic aspects of its clinical manifestation. The most recent studies concerning the possible causes of sudden hearing loss suggest vascular disorders, rupture of the inner ear membrane and autoimmune diseases; however, viral infections have received a great deal of attention in recent years. Little is known about the mechanism of sudden hearing loss. Viruses can cause

  19. Hearing Loss due to Carbon Monoxide Poisoning

    DEFF Research Database (Denmark)

    Mehrparvar, Amir Houshang; Davari, Mohammad Hossein; Mollasadeghi, Abolfazl;

    2013-01-01

    Carbon monoxide poisoning is one of the rare causes of hearing loss which may cause reversible or irreversible, unilateral or bilateral hearing loss after acute or chronic exposure. In this report, we present a case of bilateral sensorineural hearing loss in a secondary smelting workshop worker...... after an acute exposure to carbon monoxide. This complication was diagnosed by pure-tone audiometry and confirmed by transient evoked otoacoustic emissions. Hearing loss has not improved after 3 months of followup....

  20. Occurence of a round window membrane rupture in patients with sudden sensorineural hearing loss

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    Haubner Frank

    2012-11-01

    Full Text Available Abstract Background Aim of the present study was to evaluate the occurence of a round window membrane rupture and the effects of hearing restoration after exploratory tympanotomy and sealing of the round window (niche in patients with unilateral sudden deafness. Methods Retrospective analysis of patients’ charts in a tertiary referral center. Charts of 69 patients with sudden deafness followed by exploratory tympanotomy were retrospectively analyzed. Pure-tone audiometry data before and after tympanotomy were compared to determine the outcome of hearing recovery. The postoperative hearing test values were documented 3 weeks after tympanotomy. All surgical reports were reviewed with regard to the surgical technique performed and the intraoperative findings. Results 18.8% of the patients revealed a visible perilymphatic fistula in the round window niche. 89.8% of the patients reported no typical history for a round window membrane rupture. All patients were treated with an exploratory tympanotomy under local anesthesia and an intravenous corticosteroid treatment regimen. The majority of the surgeons used a fat plomb to cover the round window. Postoperative hearing was significantly improved compared to the preoperative hearing test data. No patient showed a worsened hearing curve after the treatment. Conclusion Most patients suffering from unilateral sudden deafness had no visible perilymphatic fistula. In our study population, the majority of patients reported no typical history of a pressure elevation in the inner ear. Exploratory tympanotomy is a safe procedure that may support hearing recovery in patients with sudden deafness in addition to the established treatment regimen including high-dose steroids.

  1. Risk of sudden sensorineural hearing loss in patients with systemic lupus erythematosus: a population-based cohort study.

    Science.gov (United States)

    Lin, Charlene; Lin, Shih-Wei; Weng, Shih-Feng; Lin, Yung-Song

    2013-01-01

    Sudden sensorineural hearing loss (SSHL) may be a manifestation of systemic vascular involvement in systemic lupus erythematosus (SLE) and may have an important impact on the health of patients with SLE. To investigate the risk of developing SSHL in patients with SLE, we conducted a population-based, retrospective cohort study from the Taiwan National Health Insurance Research Database. A total of 7168 patients diagnosed with SLE and 35840 control subjects without SLE were selected from claims made from 2001 to 2006. The incidence of SSHL was assessed and determined at the end of 2010. The incidence of SSHL was 2.22-fold higher in the SLE group than in the non-SLE group (6.52 vs. 2.93 per 10000 person-years), with an adjusted hazard ratio (HR) of 2.253 (95% confidence interval, CI=1.407-3.608) calculated using a Cox proportional hazard regression model. Age was an independent risk factor for SSHL, with adjusted HRs of 2.103 for individuals aged≥35 years compared with those 0-34 years. In the 0-34 age range, the incidence of developing SSHL was 4.27-fold (95% CI=2.11-8.67) higher in the SLE group compared with the non-SLE group. In female patients, the incidence of developing SSHL was 2.19-fold (95% CI=1.73-3.50) higher in the SLE group than in the non-SLE group. Systemic lupus erythematosus was significantly associated with an increased risk of developing SSHL. Scheduled auditory examinations for patients with SLE to assess the presence of chronic hearing impairment are advised to enable the early detection of SSHL.

  2. Speech recognition in normal hearing and sensorineural hearing loss as a function of the number of spectral channels

    NARCIS (Netherlands)

    Baskent, Deniz

    2006-01-01

    Speech recognition by normal-hearing listeners improves as a function of the number of spectral channels when tested with a noiseband vocoder simulating cochlear implant signal processing. Speech recognition by the best cochlear implant users, however, saturates around eight channels and does not im

  3. 突发性聋护理干预研究进展%Research development on nursing intervention of sudden sensorineural hearing loss

    Institute of Scientific and Technical Information of China (English)

    杨陆; 陈春亮; 马燕兰

    2016-01-01

    Along with sudden sensorineural hearing loss, hearing usually declines without any reason, which affects the patients′ work and life severely, and causes psychological problems like anxiety, fear, and many others. Because pathogenesis and pathomechanism of sudden sensorineural hearing loss are not yet clear according to domestic and overseas researches, there are not targeted therapies. Effective nursing intervention and health care guides can facilitate the patients with cognition of this disease, and then help them participate in the treatment positively and regain their hearing.%突发性感音神经性耳聋发作时听力常在无诱因的情况下突然下降,严重影响患者的工作生活,同时继发焦虑、恐惧等心理问题。由于国内外对突聋的病因及病理机制尚未明确,目前尚无针对性的治疗方法。有效的护理干预和保健指导工作,可以提高患者对突聋的认知程度,有助于其积极配合治疗以促进听力恢复。

  4. The paracrine effect of mesenchymal human stem cells restored hearing in β-tubulin induced autoimmune sensorineural hearing loss.

    Science.gov (United States)

    Yoo, T J; Du, Xiaoping; Zhou, Bin

    2015-12-01

    The aim of this study was to examine the activities of hASCs (Human Adipose tissue Derived Stem Cells) on experimental autoimmune hearing loss (EAHL) and how human stem cells regenerated mouse cochlea cells. We have restored hearing in 19 years old white female with autoimmune hearing loss with autologous adipose tissue derived stem cells and we wish to understand the mechanism of restoration of hearing in animal model. BALB/c mice underwent to develop EAHL; mice with EAHL were given hASCs intraperitoneally once a week for 6 consecutive weeks. ABR were examined over time. The helper type 1 autoreactive responses and T-reg cells were examined. H&E staining or immunostaining with APC conjugated anti-HLA-ABC antibody were conducted. The organ of Corti, stria vascularis, spira ligament and spiral ganglion in stem cell group are normal. In control group, without receiving stem cells, the organ of Corti is replaced by a single layer of cells, atrophy of stria vascularis. Systemic infusion of hASCs significantly improved hearing function and protected hair cells in established EAHL. The hASCs decreased the proliferation of antigen specific Th1/Th17 cells and induced the production of anti-inflammatory cytokine interleukin10 in splenocytes. They also induced the generation of antigen specific CD4(+)CD25(+)Foxp3(+)T-reg cells. The experiment showed the restoration is due to the paracrine activities of human stem cells, since there are newly regenerated mice spiral ganglion cells, not human mesenchymal stem cells derived tissue given by intraperitoneally.

  5. The internal acoustic canal - another review area in paediatric sensorineural hearing loss

    Energy Technology Data Exchange (ETDEWEB)

    Chetcuti, Karen [The Royal Children' s Hospital, Department of Medical Imaging, Parkville, VIC (Australia); Kumbla, Surekha [The Royal Children' s Hospital, Department of Medical Imaging, Parkville, VIC (Australia); Monash Health, Clayton, VIC (Australia)

    2016-04-15

    Morphological abnormalities of the internal acoustic canal (IAC), albeit rare, are sometimes associated with hearing loss in children. We present an illustration of the spectrum of IAC abnormalities together with a brief review of the embryology and anatomy of the IAC and the techniques used when imaging the petrous temporal bone. This review focuses on morphological abnormalities of the IAC together with their clinical implications and impact on clinical management. (orig.)

  6. Bilateral Sensorineural Hearing Loss and Polyneuropathy in a Patient with Sweet’s Syndrome

    OpenAIRE

    Cala, Cather M; Lauren Kole; Naveed Sami

    2015-01-01

    Sweet’s syndrome is an inflammatory systemic disease which has been associated with various underlying causes. The disease can involve multiple areas of the body including the skin and neurological system. There have been only two cases which have described otological involvement. This report presents a patient who developed loss of hearing secondary to Sweet’s syndrome after developing cutaneous involvement along with peripheral neuropathy. Despite the patient’s skin and neuropathy noticing ...

  7. " Evaluation Of Some Epidemiologic Parameters, Risk Factors, Clinical And Audiological Characteristics Of 48 Patients With Sudden Sensorineural Hearing Loss "

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    M. Amiridavan

    2006-05-01

    Full Text Available Background and Aim: Sudden Sensorineural Hearing Loss (SSNHL is an emergency situation, and is one of the most controversial subjects in domain of otolaryngology. In this article, we have analyzed some Epidemiologic Characteristics, clinical features, audiological Characteristics, and other findings in routine serological tests and MRI of 48 cases with SSNHL ,who came or were referred to us in the past 2 years. Study design: Cross sectional. Materials and Methods: In 48 patients with chief complaint of SSNHL, from June 2003 to Feb. 2005, who were admitted in clinic of otolaryngology- in Kashani Hospital -Isfahan- Iran, physical examination and history taking, audiological evaluation, MRI,and serological tests were performed in a similar way , and data were analyzed by SPSS software. Results: From 48 cases(M:28 ,F:20 with mean age of 40.9(+/-15.9 years, left ear was involved in 26 cases (54.1% ,and right ear in 19 cases (39.5% ,and in 3 cases (6.3%,both sides were involved. The severity of hearing loss was “subjectively” HIGH in 78% of patients, and the mean threshold of hearing had been calculated as 69 dB. The most common pattern in pure tone audiometry curves ,was ‘flat pattern’(75% ,and then ,’down sloping pattern’(16%.The most adjunctive clinical symptom was “tinnitus”(in 78.7%, and 40% of patients had “true vertigo”. 44.4% of our patients had some evidences of upper respiratory tract infections (URIs during recent 2 weeks. Positive family history, smoking, alcohol intake ,oral contraceptive and ototoxic drugs consumption were uncommon. 24% of cases (11 of 39 had increased ESR, and 100% of 39 patients had negative VDRL. Diabetes mellitus was the most common underlying disease (in 6 cases.From 20 patients ,who were succeeded to perform brain and ear MRI, 2 cases had tumor in internal auditory canal and cerebellopontine angle. Conclusion: SSNHL has some limitations in being studied histopathologically or in the form of

  8. 突发性聋伴耳鸣患者耳鸣特征%Characteristics of tinnitus in patients with idiopathic sudden sensorineural hearing loss

    Institute of Scientific and Technical Information of China (English)

    钟晓声; 杨海弟; 郑亿庆

    2015-01-01

    .Oftotaldeafness,low,mediumandhighfrequencytinnituswas17.1%,19.0%and 63.3% respectively.There was an linear relationship between the frequency hearing loss and tinnitus frequency (r=0.590,P90 dB HL (27.8%),and unmatched (2.6%).Tinnitus volume was correlated with the de-gree of hearing loss (r=0.216,P<0.05).④Tinnitus disability level:According to THI scores,the tinnitus disabili-ty level was:grade 1 (11.7%),grade 2 (19%),grade 3 (28.6%),and grade 4 (40.7%).⑤ The characteristics of THI and VAS scores:there was no correlation between THI scores and degree of hearing loss (r=0.087,P=0.287),no correlation between VAS score and degree of hearing loss (r=0.002,P=0.982),no correlation between THI and the logarithm of tinnitus frequency (r=-0.056,P=0.402),no correlation between VAS score and frequen-cy of tinnitus (r=-0.003,P=0.970),no correlation between THI score and tinnitus volume,r=0.03,P =0.563),no correlation between VAS score and tinnitus volume (r=0.136,P=0.110).Conclusion ① High-fre-quency tinnitus with idiopathic sudden deafness is the most common among all types of hearing loss.②There is a sig-nificant correlation between tinnitus frequency and type of hearing loss.③The frequency of the greatest hearing loss is consistent with the frequency of tinnitus.④ Tinnitus disability level is grade 3-4 during the acute period of idiopathic sudden sensorineural hearing loss.⑤ THI and VAS scores are not correlated with degree of hearing loss,tinnitus,tin-nitus volume and frequency.

  9. Sensorineural hearing loss and ischemic injury: Development of animal models to assess vascular and oxidative effects.

    Science.gov (United States)

    Olivetto, E; Simoni, E; Guaran, V; Astolfi, L; Martini, A

    2015-09-01

    Hearing loss may be genetic, associated with aging or exposure to noise or ototoxic substances. Its aetiology can be attributed to vascular injury, trauma, tumours, infections or autoimmune response. All these factors could be related to alterations in cochlear microcirculation resulting in hypoxia, which in turn may damage cochlear hair cells and neurons, leading to deafness. Hypoxia could underlie the aetiology of deafness, but very few data about it are presently available. The aim of this work is to develop animal models of hypoxia and ischemia suitable for study of cochlear vascular damage, characterizing them by electrophysiology and gene/protein expression analyses. The effects of hypoxia in infarction were mimicked in rat by partial permanent occlusion of the left coronary artery, and those of ischemia in thrombosis by complete temporary carotid occlusion. In our models both hypoxia and ischemia caused a small but significant hearing loss, localized at the cochlear apex. A slight induction of the coagulation cascade and of oxidative stress pathways was detected as cell survival mechanism, and cell damages were found on the cuticular plate of outer hair cells only after carotid ischemia. Based on these data, the two developed models appear suitable for in vivo studies of cochlear vascular damage. PMID:25987500

  10. Risk of sudden sensorineural hearing loss in stroke patients: A 5-year nationwide investigation of 44,460 patients.

    Science.gov (United States)

    Kuo, Chin-Lung; Shiao, An-Suey; Wang, Shuu-Jiun; Chang, Wei-Pin; Lin, Yung-Yang

    2016-09-01

    Poststroke sudden sensorineural hearing loss (SSNHL) can hinder communication between patients and healthcare professionals, thereby restricting participation in rehabilitation programs and limiting improvements in physical performance. However, the relationship between stroke and SSNHL remains unclear. This study employed a nationwide population-based dataset to investigate the relationship between stroke and SSNHL.The Taiwan Longitudinal Health Insurance Database was used to compile data from 11,115 stroke patients and a comparison cohort of 33,345 matched nonstroke enrollees. Each patient was followed for 5 years to identify new-onset SSNHL. Stratified Cox proportional-hazard regression analysis was used to examine the association of stroke with subsequent SSNHL.Among the 44,460 patients, 66 patients (55,378 person-years) from the stroke cohort and 105 patients (166,586 person-years) from the comparison cohort were diagnosed with SSNHL. The incidence of SSNHL was approximately twice as high among stroke patients than among nonstroke patients (1.19 and 0.63/1000 person-years, respectively). Stroke patients had a 71% increased risk of SSNHL, compared with nonstroke patients (adjusted hazard ratio [HR] 1.71, 95% confidence interval [CI] 1.24-2.36). We also observed a remarkable increase in risk of SSNHL in stroke patients within 1-year of follow-up (adjusted HR 5.65, 95% CI 3.07-10.41) or under steroid therapy during hospitalization (adjusted HR 5.14, 95% CI 2.08-12.75).Patients with stroke had a higher risk of subsequent SSNHL compared with patients without stroke. In particular, stroke patients within 1-year follow-up and those undergoing steroid therapy during hospitalization should be treated with the utmost caution, considering that the risk of SSNHL increases by more than 5-fold.

  11. The Effect of Intratympanic Dexamethasone with Oral Prednisolone as a Primary Treatment in Idiopathic Sudden Sensorineural Hearing Loss

    Directory of Open Access Journals (Sweden)

    Mohammad Taghi Khorsandi Ashtiani

    2012-01-01

    Full Text Available Introduction: Sudden sensorineural hearing loss (SSNHL is a true emergency that must be diagnosed and treated immediately. The purpose of this study is to compare the efficacy of treatment with intratympanic dexamethasone plus oral prednisolone daily or every other day with that of treatment with oral prednisolone alone. Materials and Methods: Sixty-three patients with SSNHL that had been present for less than 10 days prior to the start of treatment were randomly allocated to three different groups. Patients in group A were treated daily with oral prednisolone 1 mg/kg for 10 days plus intratympanic dexamethasone 2 mg for the first 3 days of treatment. Patients in group B were treated every other day with oral prednisolone 1 mg/kg for 10 days with the addition of intratympanic dexamethasone 2 mg for the first 3 treatments. Patients in group C were treated daily with oral prednisolone 1 mg/kg alone for 10 days. Audiometric parameters including pure tone audiometry (PTA, speech reception threshold (SRT, and speech discrimination score (SDS were assessed on days 1,5, and 10. Results: There was a significant improvement in PTA, SRT and SDS in each group over the 10 days but the greatest improvement was seen in the SRT measurements of group A in comparison with group B (19.81 ± 2.15, P=0.04 and C (26.26 ± 0.08, P=0.01. The difference in SRT between groups B and C was not statistically significant. Conclusion: The administration of intratympanic dexamethasone 2 mg daily for 3 days has an additive effect to that of 10 days of oral prednisolone 1 mg/kg in the treatment of SSNHL.

  12. Acupuncture therapy for sudden sensorineural hearing loss: a systematic review and meta-analysis of randomized controlled trials.

    Directory of Open Access Journals (Sweden)

    Xin-chang Zhang

    Full Text Available Acupuncture has commonly been used in China, either alone or in combination with Western medicine, to treat sudden sensorineural hearing loss (SSHL. The purpose of this systematic review is to assess the efficacy and safety of acupuncture therapy for patients with SSHL.We searched PubMed, the Cochrane Library, Embase, China National Knowledge Internet (CNKI, Database for Chinese Technical Periodicals (VIP, and Chinese Biomedical literature service system (SinoMed to collect randomized controlled trials of acupuncture for SSHL published before July 2014. A meta-analysis was conducted according to the Cochrane systematic review method using RevMan 5.2 software. The evidence level for each outcome was assessed using the GRADE methodology.Twelve trials involving 863 patients were included. A meta-analysis showed that the effect of manual acupuncture combined with Western medicine comprehensive treatment (WMCT was better than WMCT alone (RR 1.33, 95%CI 1.19-1.49 and the same as the effect of electroacupuncture combined with WMCT (RR 1.33, 95%CI 1.19-1.50. One study showed a better effect of electroacupuncture than of WMCT (RR 1.34, 95%CI 1.24-1.45. For mean changes in hearing over all frequencies, the meta-analysis showed a better effect with the combination of acupuncture and WMCT than with WMCT alone (MD 10.85, 95%CI 6.84-14.86. However, the evidence levels for these interventions were low or very low due to a high risk of bias and small sample sizes in the included studies.There was not sufficient evidence showing that acupuncture therapy alone was beneficial for treating SSHL. However, interventions combining acupuncture with WMCT had more efficacious results in the treatment of SSHL than WMCT alone. Electroacupuncture alone might be a viable alternative treatment besides WMCT for SSHL. However, given that there were fewer eligible RCTs and limitations in the included trials, such as methodological drawbacks and small sample sizes, large

  13. Neuroradiological imaging in patients with sensorineural hearing loss prior to cochlear implantation; Neuroradiologische Diagnostik bei Patienten mit sensorineuralem Hoerverlust vor Cochlea-Implantation

    Energy Technology Data Exchange (ETDEWEB)

    Biller, A.; Bartsch, A.; Solymosi, L.; Bendszus, M. [Abteilung fuer Neuroradiologie, Universitaet Wuerzburg (Germany); Knaus, C.; Mueller, J. [Klinik und Poliklinik fuer Hals-, Nasen- und Ohrenkranke, Universitaet Wuerzburg (Germany)

    2007-09-15

    Cochlear implantation (CI) is an established technique for enabling speech perception in patients suffering from severe bilateral sensorineural hearing loss (SNHL). Thorough preoperative radiological assessment is essential for correctly evaluating the indication for surgery and safely performing cochlear implantation. CT and conventional and functional MRI are available for radiological assessment. Therefore, knowledge of the most frequent congenital syndromal, non-syndromal, and acquired malformations of inner ear structures is fundamental. This article provides information about imaging techniques prior to CI and relevant malformations of the inner ear. Safety aspects for patients with a cochlear implant undergoing MR imaging are also discussed. (orig.)

  14. 突发性聋预后因素分析%Analysis of prognostic factors for sudden sensorineural hearing loss

    Institute of Scientific and Technical Information of China (English)

    卫旭东; 何健

    2011-01-01

    目的:探讨突发性聋预后的相关因素,指导其预后判断.方法:回顾性分析256例(280耳)突发性聋患者应用有序Logistic回归分析,筛选与突发性聋预后相关的因素,同一影响因素采用χ2检验,进一步量化指标,以指导预后分析.结果:年龄、病程、伴发症状、治疗前耳聋程度、听力曲线类型均与疗效有相关性;性别、耳聋侧别与疗效无相关性;病程≤3 d与>3~9 d疗效比较差异无统计学意义(P>0.05),>15 d、>3~9 d与>9~15 d疗效比较均差异有统计学意义(均P<0.05);不伴耳鸣或(和)眩晕的患者治疗有效率要明显高于伴耳鸣或(和)眩晕的患者(P<0.05);初诊听力曲线上升型与平坦型、其余各型总的有效率比较均差异有统计学意义(均P<0.05);初诊听阈中度与极重度疗效差异有统计学意义(P<0.05).结论:影响突发性聋预后的因素有年龄、病程、伴发症状、治疗前耳聋程度、听力曲线类型;随年龄增加,其预后呈不良趋势,以40岁为界,预后明显变差;发病9 d以内疗效较好,其后有效率明显下降;伴耳鸣或(和)眩晕的患者预后明显差于不伴耳鸣或(和)眩晕的患者;下降型听力曲线发病率最高,但上升型曲线疗效明显好于其他组;治疗前的听阈水平与疗效并非简单的线性关系,中度水平的听阈疗效最好,极重度疗效最差,随听阈提高,总体疗效呈下降趋势.%Objective: To analysis the prognostic factors of the sudden sensorineural hearing loss (SHL),to predict the prognosis of patient with SHL precisely. Method: Two hundred and fifty-six cases (280 ears) with SHL were reviewed retrospectively during January 2005 to Jun 2009. Possible influence factor was analysis with logistic stepwise regression to investigate the correlation with prognosis. All verified influence factors was analysis with single-factor analysis of variance. Result: The prognosis of SHL related to age, the trouble time before

  15. Efficacy comparison of oral steroid, intratympanic steroid, hyperbaric oxygen and oral steroid + hyperbaric oxygen treatments in idiopathic sudden sensorineural hearing loss cases.

    Science.gov (United States)

    Alimoglu, Yalcin; Inci, Ender; Edizer, Deniz Tuna; Ozdilek, Alper; Aslan, Mehmet

    2011-12-01

    Idiopathic sudden sensorineural hearing loss is a rare disorder of unknown pathogenesis in which hearing is lost partially or totally. About 60 treatment modalities have been described. We aimed to compare the efficacy of hyperbaric oxygen, oral steroid, intratympanic steroid therapy and their combinations in idiopathic sudden sensorineural hearing loss patients. Files of patients who were followed up between 2004 and 2010 in our clinic were examined retrospectively. Patients were divided into four groups according to the therapy received: Oral steroid, oral steroid + hyperbaric oxygen, intratympanic steroid and hyperbaric oxygen. Treatment success was assessed by Siegel criteria and mean gains using pre-treatment and post-treatment audiograms. 217 patients and 219 ears were examined. The proportion of patients responding to therapy was the highest in the oral steroid + hyperbaric oxygen group with 86.88% (53/61) followed by the oral steroid group with 63.79% (37/58), the intratympanic steroid group with 46,51% (20/43) and the hyperbaric oxygen group with 43.85% (25/57). The proportion of patients who had complete recovery was the highest in the oral steroid + hyperbaric oxygen group with 42.6% (26/61) followed by the oral steroid group with 19.0% (11/58), the hyperbaric oxygen group with 17.5% (10/57) and the intratympanic steroid group with 11.6% (5/43). The oral steroid + hyperbaric oxygen group has the highest mean hearing gain among all groups (p hearing loss patients receiving oral steroid + hyperbaric oxygen combination therapy have a higher likelihood of recovery than patients receiving oral steroids, hyperbaric oxygen or intratympanic steroids alone.

  16. Perda auditiva sensorioneural em pacientes com acromegalia em tratamento Sensorineural hearing loss in acromegalic patients under treatment

    Directory of Open Access Journals (Sweden)

    Marcelo Alexandre Carvalho

    2012-08-01

    Full Text Available Acromegalia é uma doença endócrina rara. Poucos estudos avaliaram sua associação com deficiência auditiva (DA e os resultados são conflitantes. OBJETIVOS: Avaliar a prevalência e características da DA em um grupo de pacientes com acromegalia em tratamento. Analisar a transmissão auditiva central e periférica. MATERIAL E MÉTODOS: Estudo transversal. Um grupo de 34 pacientes com acromegalia submeteu-se à avaliação metabólica, audiometria tonal e potenciais evocados auditivos de tronco encefálico (PEATE. Considerou-se DA quando a média dos tons puros foi > 25 DBNA para baixas frequências (250, 500, 1000 e 2000 Hz ou altas frequências (3000, 4000, 6000 e 8000 Hz. Os pacientes foram divididos em grupo A (com DA e B (sem DA. RESULTADOS: Doze pacientes (35,3% mostraram DA sensorioneural (grupo A, sendo oito bilateral e quatro unilateral. Nenhum apresentou DA mista ou condutiva. A prevalência de diabetes/intolerância à glicose de jejum foi similar entre os grupos. As frequências de 3000, 4000, 6000 e 8000 Hz foram as mais afetadas e com padrão similar em ambos os lados. CONCLUSÃO: DA sensorioneural esteve presente em 35,3% dos casos. Não foram notadas diferenças clínicas ou metabólicas significativas entre os grupos, bem como na transmissão neural auditiva periférica e central.Acromegaly is a rare endocrine disease. Few studies have evaluated its association with hearing loss (HL and the results are conflicting. AIM: To evaluate the prevalence and features of HL in a group of patients being treated for acromegaly. To analyze peripheral and central auditory transmission. METHODS: Cross-sectional study. A group of 34 patients with acromegaly were submitted to metabolic evaluation, tonal audiometry and brainstem auditory evoked potentials. HL was considered when pure tone average was > 25 DBHL for low frequencies (250, 500, 1000 and 2000 Hz or high frequencies (3000, 4000, 6000 and 8000 Hz. The patients were divided in group

  17. Intratympanic steroids as primary initial treatment of idiopathic sudden sensorineural hearing loss. The Hospital Universitario Ramón y Cajal experience and review of the literature.

    Science.gov (United States)

    Labatut, Tomás; Daza, María José; Alonso, Antonio

    2013-11-01

    The objective of this study was to determine the effectiveness, dosage, safety and comfort of intratympanic steroids as primary initial treatment of idiopathic sudden sensorineural hearing loss (ISSHL). Prospective nonrandomized clinical practice study was performed in Tertiary referral center university hospital. A total of 35 consecutive patients suffering from newly diagnosed sudden sensorineural hearing loss with mean pure-tone average thresholds of 81 ± 21 dB were treated. No previous therapy had been undertaken. Intratympanic steroid injection as primary initial treatment was administered during 2 weeks on a twice a week schedule, between 2010 and 2011. Treatment was started on average within 2 days of symptoms onset. Pre and post-treatment audiometric evaluations were analyzed on follow-up as well as tolerance of the procedure and possible adverse effects. 66-85 % of patients achieved successful treatment according to the different outcome criteria used to evaluate hearing improvement (Furuhashi criteria/improvement of ≥10 dB in pure-tone average). Mean post-treatment improvement regarding pure-tone average was 34 ± 21 dB. A 48 ± 43 % improvement in speech discrimination score was observed. Patients received an average of 18 mg of methylprednisolone per injection and a total dose of 72 mg per treatment cycle. No serious adverse effects were noted. Intratympanic steroid injection is an effective, safe and well-tolerated office based-procedure for the treatment of ISSHL as primary initial treatment that can avoid the potential adverse effects of systemic steroids. A higher dose, schedule of administration as well as standardization of hearing recovery criteria still need to be established.

  18. Perda auditiva sensorioneural no lúpus eritematoso sistêmico: relato de três casos Sensorineural hearing loss in systemic lupus erythematosus: report of three cases

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    Suzana B. Cecatto

    2004-06-01

    Full Text Available INTRODUÇÃO: O Lúpus Eritematoso Sistêmico (LES é uma doença sistêmica do tecido conectivo, de etiologia desconhecida, provavelmente multifatorial. Acomete principalmente o sexo feminino podendo afetar múltiplos órgãos, dentre eles o sistema auditivo. A orelha interna pode ser lesada por diversos mecanismos auto-imunes, sendo a manifestação mais freqüente a disacusia sensorioneural flutuante, geralmente bilateral, rapidamente progressiva e com boa responsividade a imunossupressores. OBJETIVO: O objetivo deste trabalho é relatar três casos de disacusia de etiologia auto-imune, enfocando formas de acometimento e manifestações clínicas, bem como correlacionando o efeito ototóxico da cloroquina - droga empregada no controle do LES - com a perda auditiva. CONCLUSÃO: As perdas auditivas sensorioneurais súbitas, rapidamente progressivas ou flutuantes, podem ocorrer em pacientes com doença auto-imune e devem ser sempre lembradas nos casos de disacusia sem causa aparente.INTRODUCTION: The Systemic Lupus Erythematosus (SLE is a systemic disease of the connective tissue, with unknown etiology, probably associated to multiple events. It is a multiple organs disease that affects mainly women. The inner ear can be damaged by several immunopathogenic mechanisms, and the most common symptom is a progressive sensorineural hearing loss, generally bilateral, with good response to immunossupression. AIM: The purpose of this article is to report three cases of women suffering from SLE and hearing loss and to establish a link between the autoimmune and the vascular mechanisms of the disease, also focusing attention on the ototoxicity due to chloroquine applied during the treatment of SLE. CONCLUSION: Sudden or fluctuant sensorineural hearing loss may affect patients with autoimmune disease, so it must always be taken into account when dealing with patients suffering from hearing loss without any apparent cause.

  19. An Animal Model of Sudden Onset Sensorineural Hearing Loss with Vestibular Function Disturbances Induced By Mitochondrial Toxin

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    ZOU Jing; ZHANG Ya; PYYKK(O) Ilmari; WU Hao

    2006-01-01

    To establish an animal model of sudden onset sensorineural hearing loss (SSNHL) to study its mechanisms. Materials and methods The inner ear was exposed to 3-nitropropionic acid at 0.5 mol/L (3-NP (H)) and 0.3 mol/L (3-NP (L)) through the round window membrane for 30 minutes in 50 male guinea pigs. Thresholds of auditory brainstem responses (ABR) were established before the treatment and retested at 4 hours, 1 day, 3 days and 6 days following 3-NP exposure. Control animals were treated with phosphate buffered saline (PBS) and their ABRs were retested at 4 hours and 1 day after the treatment. Animals were monitored for nystagmus and postural signs of vestibular dysfunction, using a digital video camera, following the treatment procedure. Specimens were taken at 12 hours, 1 day, 3 days and 7 days following 3-NP (H) exposure and embedded in JB4 for light microscopy observation. Results ABRs were lost in all animals tested at 4 hours following 3-NP (H) exposure. The rate of complete ABR loss decreased as post-treatment test time increased. ABRs were lost in 80% (4/5) of the animals at 1 day after exposure to 3-NP (L). Spontaneous horizontal nystagmus with a fast phase away from the treated ear developed in all 3-NP (H)-treated animals and in 20 % (1/5) of the animals exposed to 3-NP (L), except for the one treated bilaterally. Various degree of postural disturbances consistent with unilateral vestibular dysfunction, such as spontaneous barrel rolling towards the exposure side while walking, were seen in all animals exposed to 3-NP(H) and 40% (2/5) of animals exposed to 3-NP(L), except for the one animal treated bilaterally, which showed no signs of imbalance. Both nystagmus and postural disturbances resolved in 2 days following 3-NP exposure. Histological study showed temporary edema tin the organ or Corti, Claudius cells and the inner sulcus cells 3 days after 3-NP (H) treatment. Enlargement of intercellular space in the spiral prominence was first noticed at 12 hours

  20. Intracranical infections presented with sudden sensorineural hearing loss%以突聋为首发症状的颅内感染性疾病的临床特征分析

    Institute of Scientific and Technical Information of China (English)

    叶星; 王晓宇

    2011-01-01

    Objective To characterize clinical, auditory and imaging features of patients who present with sudden sensorineural hearing loss as the prodrome of an intracranial infection, in order to improve diagnosis. Methods Five cases of intracranial infection that were initially diagnosed as sudden sensorineural hearing loss were revisited. Results Four of these patients were males and 1 was female. All 5 patients presented with hearing loss. Vertigo or vestibular dysfunction, headaches and nausea/vomiting were seen in 4 cases, and fever in 3 cases. Audiological tests showed severe sensorineural hearing loss in all cases, bilateral in 3 and unilateral in 2 cases, with absent acoustic stapedial reflex. ABR and DPOAEs were also abnormal in all cases. MRI studies showed signs of infection changes in the brain. Final diagnoses included acute cerebellitis,viral encephalitis and tuberculous meningitis. Conclusions Clinicians should consider the possibility of intracranial lesions when facing a patient with sudden hearing loss, especially when symptoms include headaches, vertigo and fever. MRI, ABR and lumbar puncture may help avoid misdiagnosis.%目的 探讨以突发性耳聋为首发症状的颅内感染性疾病的临床特点、听力学及影像学表现,以减少误诊.方法 对5例以突发性耳聋为首发症状的颅内感染性疾病患者的临床资料、诊断过程以及疾病转归进行分析.结果 5例患者中男4例,女1例,临床表现:听力下降5例,眩晕伴走路不稳3例,头痛伴恶心呕吐4例,发热3例.纯音测听5例均为感音神经性耳聋,双耳3例,单耳2例;声导抗测听鼓室曲线A型5例,声反射不能引出4例;DPOAE检查4例不能引出,前庭功能检查半规管功能低下3例.ABR检查2例为蜗后性改变,影像学检查CT无特殊表现;MRI检查未见明显异常1例,呈现炎症性改变4例.腰穿正常2例,脑脊液压力增高、细胞数高3例.最后确诊疾病:急性小脑炎1例,病毒性脑炎2

  1. Epidemiology of prelingual sensorineural hearing impairment at a children’s center in Bogotá, Colombia between 1997 and 2008

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    Claudia Talero-Gutiérrez

    2011-06-01

    Full Text Available Introduction: Hearing loss is a frequent problem in childhood with an incidence of about one case per 1000 births. Control of deafness should be aimed at prevention and early diagnosis in efforts to provide appropriate treatment and stimulate adequate communication in children affected. The objective of this study was to determine the prevalence of different etiologies among deaf children with a diagnosis of prelingual sensorineural hearing loss referred to the Fundación CINDA in Bogotá, Colombia, between 1997 and 2008.Materials and methods: The medical records were selected from those with prelingual hearing loss. Information was gathered in a format containing variables related to the risk factors suggested by the Joint Committee of Infant Hearing.Results: We studied 254 children; boys and girls were equally distributed. The most common etiological diagnosis was «unknown cause», followed by genetic causes (31 cases, and 38 cases from TORCH infections (toxoplasmosis, others – syphilis, rubella, cytomegalovirus, herpes, with rubella as the most common cause.Conclusions: Review of prenatal, perinatal, and postnatal history often reveals the cause of the deafness in children; therefore, appropriate evaluation of pregnant mothers could result in decreased frequency of deafness in children in our country.

  2. Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss: a prospective clinical trial

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    Teramukai Satoshi

    2010-11-01

    Full Text Available Abstract Background Sudden sensorineural hearing loss (SSHL is a common condition in which patients lose the hearing in one ear within 3 days. Systemic glucocorticoid treatments have been used as standard therapy for SSHL; however, about 20% of patients do not respond. We tested the safety and efficacy of topical insulin-like growth factor 1 (IGF1 application using gelatin hydrogels as a treatment for SSHL. Methods Patients with SSHL that showed no recovery to systemic glucocorticoid administration were recruited. We applied gelatin hydrogels, impregnated with recombinant human IGF1, into the middle ear. The primary outcome measure was the proportion of patients showing hearing improvement 12 weeks after the test treatment. The secondary outcome measures were the proportion of patients showing improvement at 24 weeks and the incidence of adverse events. The null hypothesis was that 33% of patients would show hearing improvement, as was reported for a historical control after hyperbaric oxygen therapy. Results In total, 25 patients received the test treatment at a median of 23 days (range 15-32 after the onset of SSHL, between 2007 and 2009. At 12 weeks after the test treatment, 48% (95% CI 28% to 69%; P = 0.086 of patients showed hearing improvement, and the proportion increased to 56% (95% CI 35% to 76%; P = 0.015 at 24 weeks. No serious adverse events were observed. Conclusions Topical IGF1 application using gelatin hydrogels is well tolerated and may be efficacious for hearing recovery in patients with SSHL that is resistant to systemic glucocorticoids.

  3. Malignant meningitis secondary to oesophageal adenocarcinoma presenting with sensorineural hearing loss: a series of three cases and discussion of the literature.

    Science.gov (United States)

    Adams, Mark; Doherty, Carolynne; O'Kane, Anna; Hall, Samuel; Forbes, Raeburn B; Herron, Brian; McNaboe, Edward J

    2016-09-01

    Malignant meningitis may rarely present to the otolaryngologist. We report our experience with 3 patients presenting with sudden, progressive bilateral sensorineural hearing loss secondary to malignant meningitis. The primary tumour in all 3 cases was oesophageal adenocarcinoma. All 3 cases were notable for the rapidity of the patients' clinical deterioration; the interval from presentation to death ranged from 21 to 28 days. We suggest that otolaryngologists should remain vigilant to the possibility of this devastating diagnosis and have a low threshold for further investigation in patients with suspicious features. It is important to note that initial MRI and lumbar puncture may be negative and repeat testing should be undertaken if there is clinical suspicion. PMID:26645106

  4. Prevalence of Epileptiform Discharges in Children with Sensori-Neural Hearing Loss and Behavioral Problems Compared to Their Normal Hearing Peers

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    Susan AMIRSALARI

    2014-04-01

    Full Text Available 800x600 How to Cite This Article: Amirsalari S, Radfar Sh, Ajallouyean M, Saburi A, Yousefi J, Noohi S, Tavallaie SA, Hassanalifard M, Ghazavi Y. Prevalence of Epileptiform Discharges in Children with Sensori-Neural Hearing Loss and Behavioral Problems Compared to Their Normal Hearing Peers. Iran J Child Neurol. 2014 Spring 8(2:29-33.ObjectiveOveractivity and behavioral problems are common problems in children with prelingually profound sensorineural hearing loss (SNHL. Data on epileptiform electroencephalography (EEG discharges in deaf children with psychologicaldisorders are so limited. The primary focus of this study was to determine the prevalence of epileptiform discharges (EDs in children with SNHL and overactivity or behavioral problems.Materials & MethodsA total of 262 patients with prelingually profound SNHL who were referred to our cochlear implantation center between 2008 and 2010 were enrolled in this study. Children with SNHL who had diagnosis of overactivity and/or behavioralproblems by a pediatric psychiatrist, underwent electroencephalography (EEG.EEG analysis was carried out by a board-certified pediatric neurologist. The control group consisted of 45 cases with overactivity or behavioral problems and normal hearing.ResultsOne hundred thirty-eight children with mean age of 3.5±1.23 year were enrolled in the case group, of whom 88 cases (63.7% were boy. The control group consisted of 45 cases with mean age of 3.2±1.53 years, of whom 30 (66.6%cases were male. EDs were detected in 28 (20.02% children of the case group (with SNHL in comparison with 4 (8.88% in the control group (without SNHL, which was statistically significantly different.ConclusionIn this study, we obtained higher frequency of EDs in deaf children with overactivity and/or behavioral problem compared to the children without SNHL. Further studies are required to evaluate the possible association of SNHL withEDs in overactive children.References1

  5. 影响突发性聋预后因素的临床研究%Prognostic factors for patients with the idiopathic sudden sensorineural hearing loss

    Institute of Scientific and Technical Information of China (English)

    赵晖; 张天宇; 景江华; 傅窈窈; 罗嵇宁

    2008-01-01

    目的 研究影响突发性聋预后的相关因素,提高突发性聋预后的判断.方法 回顾性分析2006年1月至2007年3月复旦大学附属眼耳鼻喉科医院收治的突发性聋患者,首先去除初始听阈≤40 dB的低频聋患者,得到882例进行疗效分析.初始听阈>40 dB的患者按不同的初始听阈形态与严重程度分为下坡型组(69例)、上坡型组(24例)、平坦型组(139例)、凹陷型组(44例)、极重度聋(126例)和全聋(86例)6组.结果 病程3 d内疗效最佳,其次是1、2周内,超过2周疗效差,3周内和1个月内、1个月后差异无统计学意义.病程2周内患者初始听阈>40 dB组中凹陷型组与其他组相比预后最佳,恢复率达97.7%.极重度聋组和其他组(除全聋组)相比,治愈率(23.8%)及恢复率(57.9%)低,但好于全聋组.全聋组的预后最差,无效率达67.4%.合并有糖尿病、高血压患者的预后与其他不伴此病的患者相比差异具有统计学意义(H=4.455,P=0.0348).年龄与预后有关,年龄越大,预后也越差,以50岁为界,<50岁的患者的预后要好于≥50岁的患者,差异有统计学意义(H=7.739,P=0.0054).结论 病程大于2周的患者疗效差,不同的初始听阈形态与听力损失程度是影响突发性聋预后的重要因素.年龄越大预后越差.合并有高血压、糖尿病的患者,其预后比无任何合并症的患者差.%Objective To assess the prognostic factors associated with the sudden idiopathic sensorineural hearing loss,to predict the prognosis of patient with idiopthic sensorneural hearing loss precisely.Methods Eight hundreds and eishty two patients with idiopathic sudden sensorineural hearing loss were retrospectively reviewed during January 2006 to March 2007.Patients whose initial hearing threshold ≤40 dB were excluded.The patients with initial hearing threshold >40 dB were recruited,which was divided into six subgroups based on the patterns of audiogram:downgrade audiogram subgroup

  6. Metilprednisolona intratimpânica como terapia de resgate na surdez neurossensorial súbita Intratympanic methylprednisolone as rescue therapy in sudden sensorineural hearing loss

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    Igor Teixeira Raymundo

    2010-08-01

    Full Text Available O tratamento da surdez súbita é uma das questões mais controversas da Otologia. No entanto, os corticoides sistêmicos têm sido a opção mais escolhida por referidos autores como padrão ouro de tratamento. O uso de corticoide intratimpânico como terapia de segunda linha para tratamento de casos refratários de surdez súbita tem sido relatado e os resultados promissores têm feito alguns autores promoverem o seu uso como terapia de primeira linha, indicando-a para todos os casos de surdez súbita. OBJETIVOS: Descrever essa nova modalidade de tratamento e avaliar a sua segurança e eficácia em quatorze pacientes tratados após falha da corticoterapia oral. MATERIAIS E MÉTODOS: Trata-se de estudo analítico prospectivo em que quatorze pacientes portadores de surdez súbita neurossensorial foram tratados com metilprednisolona intratimpânica após falha da corticoterapia oral. Limiares tonais e o índice de reconhecimento de fala pré-tratamento e pós-tratamento foram analisados. RESULTADOS: Dez dos quatorze pacientes tratados com metilprednisolona intratimpânica apresentaram recuperação da audição superior a 20 dB nos limiares tonais ou 20% no IRF. CONCLUSÃO: Três injeções intratimpânicas de metilprednisolona aumentaram os limiares tonais e índices de reconhecimento da fala em um grupo de pacientes portadores de surdez súbita neurossensorial que não obtiveram benefício após corticoterapia oral.Treatment in sudden sensorineural hearing loss is a contentious issue, today, oral steroids are the most common choice and considered the best treatment option, but the use of intratympanic steroids has become an attractive alternative, especially in cases when systemic therapy fails, or to avoid the side effects of the systemic use of steroids. AIM: To describe the results of intratympanic methylprednisolone in idiopathic sudden sensorineural hearing loss after failure of oral prednisolone. METHODS: In a prospective study fourteen

  7. Early Detection and Intervention for Sensorineural Hearing Loss%感音神经性耳聋的早期识别与临床干预

    Institute of Scientific and Technical Information of China (English)

    刘博; 王硕

    2015-01-01

    感音神经性耳聋是临床常见问题,若不能及时发现和正确干预,可导致儿童听觉言语发育迟缓,以及情感、心理和社会交往等综合能力的发展。新生儿听力筛查与新生儿基因筛查使得感音神经性耳聋的早期发现成为可能。儿童期的听力筛查工作很大程度上弥补了因迟发性、渐进性或获得性听力损失导致的新生儿听力筛查漏诊的不足。感音神经性耳聋通过主客观听力检测技术可获得早期诊断,通过药物治疗、选配助听装置等获得早期干预。永久性感音神经性听力损失作为一种慢性疾病,传统的以医生为中心的医疗服务模式不足以满足患者需求,以患者、家庭或社区为中心的医疗服务模式逐渐被重视。%Sensorineural hearing loss (SNHL) is commonly seen in clinical practice. Without early detection and appropriate intervention, it may cause delayed hearing and speech development and relevant emotional, psychological and social communication problems in children. The universal newborn hearing screening (UNHS) program and newborn genetic screening for deafness makes it possible to detect the SNHL in the early stage, while the hearing screening program for children can identify the children with delayed-onset, progressive or acquired hearing loss. SNHL can be early diagnosed using both subjective and objective hearing tests, and early intervened with medicine, hearing devices and other methods. As a chronic disease, SNHL patients may not be satisfied by the traditional clinician-centered medical service model, so the patient-centered, family-centered and community-centered models are gradually encouraged in recent years.

  8. Detection of Perinatal Cytomegalovirus Infection and Sensorineural Hearing Loss in Belgian Infants by Measurement of Automated Auditory Brainstem Response▿

    OpenAIRE

    Verbeeck, Jannick; Van Kerschaver, Erwin; Wollants, Elke; Beuselinck, Kurt; Stappaerts, Luc; Van Ranst, Marc

    2008-01-01

    Since auditory disability causes serious problems in the development of speech and in the total development of a child, it is crucial to diagnose possible hearing impairment as soon as possible after birth. This study evaluates the neonatal hearing screening program in Flanders, Belgium. The auditory ability of 118,438 babies was tested using the automated auditory brainstem response. We selected 194 babies with indicative hearing impairment and 332 matched controls to investigate the associa...

  9. Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio: Novel Markers for Diagnosis and Prognosis in Patients with Idiopathic Sudden Sensorineural Hearing Loss

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    Young Joon Seo

    2014-01-01

    Full Text Available Background. We aim to provide useful evidence about the association of neutrophil-to-lymphocyte ratio (NLR and platelet-to-lymphocyte ratio (PLR with idiopathic sudden sensorineural hearing loss (ISSNHL and its possibility of emerging as a cheap, reliable, and independent prognostic marker of ISSNHL. Methods. 348 patients diagnosed with ISSNHL were included in our retrospective data analysis. Blood samples and the hearing assessments of the patients were carried out. Then, the patients were divided into 2 groups as “recovered” and “unrecovered” according to their response to the treatment. Results. Both mean NLR and PLR values of the ISSNHL patients were significantly higher than the control group (both P<0.001. The NLR value was 5.98±4.22 in the unrecovered group and 3.50±3.38 in the recovered group (P<0.001. After adjustment in a binary logistic regression model, only NLR value was associated with the recovery of ISSNHL (P=0.001. Discussion. We demonstrated for the first time that NLR and PLR values were significantly high in ISSNHL patients. Also the NLR level might be taken into account as a novel potential marker to predict the patients’ prognosis in terms of recovery.

  10. 鼻咽癌放疗后突发感音神经性聋14例临床分析%Clinical analyses of sudden sensorineural hearing loss in 14 nasopharyngeal carcinomas following radiotherapy

    Institute of Scientific and Technical Information of China (English)

    陈平; 唐安洲; 张哲; 尹时华; 蔡红武; 方勤; 何光耀

    2011-01-01

    Objective To investigate the clinical characteristics and effects of sudden sensorineural hearing loss in nasopharyngeal carcinoma (NPC) following radiotherapy. MethodsThe clinical characteristics and effects in 14 NPC patients ( 15 ears) with sudden sensorineural hearing loss following radiotherapy were retrospectively analyzed. Results The sudden sensorineural hearing loss happened more in male subjects than female subjects and more in the left ear than the right ear. Its occurrence time was averagely 6.6 years following radiotherapy. Most of the patients suffered hearing loss prior to the sudden sensorineural hearing loss. The 250, 500, 1000, 2000, 4000 Hz average hearing thresholds: sudden hearing loss ears ( 78.5 ± 24.7 ) dBHL, none-sudden hearing loss ears (57.0 ± 32.4 ) dBHL, among which,73.33%( 11/15 ) for sensorineural hearing loss, 26.67% (4/15) for mixed hearing loss. 12 cases had complications following radiotherapy. At least one case had posterior circulation barrier. The total effective rate was 26.67% (4/15) and four cases had relapsed and in vain thereafter. Conclusions In NPC patients who received radiotherapy, it caused more serious sudden sensorineural hearing loss and the treatment effects were poor and hearing loss was susceptible to relapse. The pathogenesis may be related to the radiation caused posterior circulation disorders.%目的 探讨鼻咽癌放射治疗后突发感音神经性聋患者的临床特点及疗效,以利临床诊治。方法 回顾性分析14例(15耳)鼻咽癌放疗后突发感音神经性聋患者的临床特点及疗效。结果 鼻咽癌放射治疗后突发感音神经性聋的患者中男10例、女4例,左耳10耳、右耳5耳,平均发生时间为放疗后6.6年,突聋前多存在听力损失。250、500、1000、2000、4000 Hz的平均听阈(听力级):突聋耳为(78.5±24.7) dB,非突聋耳为(57.0±32.4) dB。突聋耳73.33% (11/15)为感音神经性聋,26.67%为混合性聋(4

  11. 糖皮质激素鼓室给药治疗突发性聋的现况分析%Current State of Intratympanic Glucocorticoids Treatment for Sudden Sensorineural Hearing Loss

    Institute of Scientific and Technical Information of China (English)

    刘璐; 钟时勋

    2015-01-01

    突发性聋是耳鼻喉科常见的急症,目前临床上全身使用糖皮质激素治疗突发性聋获得较为肯定的疗效,但全身使用糖皮质激素的禁忌症及可能引起严重的不良反应,使得糖皮质激素鼓室给药治疗突发性聋逐渐得到应用并成为广泛关注的热点。本文将对糖皮质激素鼓室给药的疗效进行评估,以及对其临床运用的现况进行阐述。%Sudden sensorineural hearing loss is a common emergency in otolaryngology. Currently, systemic glucocorti⁃coids is a commonly used treatment with certain efficacies, but concerns over potentially serious adverse reactions as contraindi⁃cations remain. Hence intratympanic glucocorticoids injection for sudden sensorineural hearing loss has gradually attracted at⁃tention. This article evaluates the efficacy of this treatment in sudden sensorineural hearing loss, and elaborates on its clinical application.

  12. 感音神经性听力损失患者助听后言语感知能力的评价%Speech perception performance in patients with sensorineural hearing impairment aided with hearing aids

    Institute of Scientific and Technical Information of China (English)

    王硕; 董瑞娟; Solveig Christina Voss; 钱金宇; 吴燕君; 张华

    2015-01-01

    目的:本研究对感音神经性听力损失患者助听器选配后的言语识别能力进行评价,并分析听力损失程度与年龄对助听后言语康复效果的影响。方法30名感音神经性听力损失受试者,男13名,女17名,年龄26-86岁,双侧听力损失程度对称,双耳0.5-4 kHz频率下纯音听力阈值(PTA0.5-4 kHz)平均值40~75 dB HL。所有受试者均选配Phonak Bolero Q50系列耳背式助听器。使用汉语普通话言语测试软件(Mandarin Speech Test Materials, MSTMs)进行裸耳和助听后安静与噪声环境下言语识别能力测试。结果(1)助听后,安静环境下的双音节识别率平均提高35.1±19.5%;噪声环境下语句识别率平均提高32.8±22.8%;(2)助听后言语识别能力与听力损失程度呈显著负相关关系;(3)助听优势高于平均水平的受试者纯音听阈均大于50 dB HL,但存在个体差异大的特点。结论助听器选配可以有效帮助感音神经性听力损失患者提高言语识别能力,但听力损失程度不是唯一影响助听效果的因素,助听后言语识别能力的改善存在较大个体差异。%Objective This study was aimed at evaluating the speech perception performance in sensorineural hear-ing-impaired listeners with hearing aids. Methods Thirty subjects with sensorineural hearing loss were recruited, including 13 males and 17 females with the age ranging from 26 to 86 years. They had bilaterally symmetric hearing loss with the av-eraged 0.5-4 kHz PTA ranging from 40 to 75 dB HL. They were fitted with Phonak Bolero Q50 BTE hearing aids unilaterally. The Mandarin Speech Test Materials (MSTMs) software was used to test speech perception performance under four condi-tions, including unaided quiet, aided quiet, unaided noisy and aided noisy environments. Results (1) After fitting hearing aids, the speech perception score in quiet using bisyllabic materials improved by 35.1±19.5%in average

  13. 突发性耳聋预后的相关因素探讨%Analysis of relevant factors on prognosis of idiopathic sudden sensorineural hearing loss

    Institute of Scientific and Technical Information of China (English)

    赵璟; 桂晓钟

    2015-01-01

    目的:探讨影响突发性耳聋预后的相关因素。方法286例突发性耳聋患者治疗前和治疗后进行纯音听阈测试对比,探讨影响预后的相关因素。结果突发性耳聋预后与患者的发病时间、年龄大小、听力损失情况、有无眩晕、高血压、糖尿病及焦虑情绪有关,而与性别无关。结论突发性耳聋患者发病时间越长、年龄越大、听力损失越重,治疗预后越差。听力图中,高频型和水平型比中频型和低频型预后差,全聋型最差。不伴眩晕、无高血压高血脂糖尿病、无焦虑情绪的突发性耳聋患者疗效明显好于伴眩晕、有高血压高血脂糖尿病、有焦虑情绪患者。%Objective To evaluate the factors that may affect the prognosis of hearing recovery in cases of idiopathic sudden sensori-neural hearing loss( ISSHL) . Methods Through retrospective analysis of the 286 cases of ISSHL that were diagnosed and treated in our de-partment, and comparison between changes in pure tone threshold audiometry before and after treatment, the correlation factors of prognosis of ISSHL were explored. Results The prognosis was correlated with patients' morbidity time, age, degree of hearing loss, hearing loss curve type, disease of high blood pressure, dizziness and diabetes, and anxiety, and no correlation with gender was found. Conclusion The youn-ger the patients with ISSHL were, and the shorter the time of onset was, the better the prognosis would be. The efficacy of ISSHL without ver-tigo, underlying diseases and anxiety was significantly better than that with vertigo, underlying diseases and anxiety. Among various types of hearing loss curve, the prognoses of intermediate-frequency type and low-frequency type were better than those of high-frequency type and horizontal type, and the deaf type came the worst.

  14. [Clinical features associated with sudden hearing loss in children].

    Science.gov (United States)

    Taiji, Hidenobu; Morimoto, Noriko

    2012-07-01

    Sudden sensorineural hearing loss is usually unilateral, and the cause is not identified in most adult cases. However, a specific cause has frequently been found in the case of children, in whom idiopathic sudden sensorineural hearing loss (ISHL) is comparatively rare. We investigated 20 cases of acute unilateral sensorineural hearing loss in children associated with a certain disease, but which was first diagnosed as ISHL. Thirteen patients aged 6 to 16 years old were diagnosed as having psychogenic (functional) hearing loss. Discrepancies in behavioral and objective tests are most valuable when functional hearing loss is suspected. Elevated pure-tone thresholds associated with normal distortion product otoacoustic emissions (DPOAEs) enable prompt further investigation. There are several conditions that may mimic functional hearing loss, so auditory brainstem response (ABR) testing is necessary to verify the actual cause. The unilateral profound hearing loss in 2 patients aged 7 and 11 years old was due to asymptomatic mumps proven by detecting the mumps IgM antibody. Total hearing recovery in the 125-1000 Hz frequencies occurred in one case. In 5 patients aged 6 to 12 years old with acute hearing loss and vertigo, high resolution CT imaging showed an abnormally enlarged vestibular aqueduct on the affected side. Large vestibular aqueduct syndrome should be considered in acute high-frequency sloping hearing loss with an A-B gap at low frequencies.

  15. Comparação entre critérios de recuperação auditiva na perda neurossensorial súbita Comparison of hearing recovery criteria in sudden sensorineural hearing loss

    Directory of Open Access Journals (Sweden)

    Daniel Paganini Inoue

    2012-06-01

    Full Text Available Inúmeros métodos de análise da recuperação auditiva na perda auditiva neurossensorial súbita idiopática (PANSI dificultam a comparação adequada dos diversos tratamentos encontrados na Literatura. OBJETIVO: Comparar diversos critérios de recuperação auditiva na PANSI, baseados na Literatura. MATERIAL E MÉTODO: Foi realizado um estudo clínico observacional de coorte, a partir de um protocolo prospectivo, em pacientes com PANSI, atendidos entre 2000 e 2010. Foram comparados cinco critérios de recuperação auditiva significativa e quatro critérios para recuperação completa, pela audiometria tonal, por meio de teste não paramétrico e de comparações múltiplas, ambos com um nível de significância de 5%. Após determinação do critério de recuperação auditiva mais rígido, foram adicionados parâmetros da audiometria vocal. RESULTADOS: Houve diferença significativa, entre esses critérios (p The countless methods available to analyze hearing recovery in idiopathic sudden sensorineural hearing loss (ISSHL cases hinder the comparison of the various treatments found in the literature. OBJECTIVE: This paper aims to compare the different criteria for hearing recovery in ISSHL found in the literature. MATERIALS AND METHODS: This is an observational clinical cohort study from a prospective protocol in patients with ISSHL, treated between 2000 and 2010. Five criteria were considered for significant hearing recovery and four for complete recovery by pure tone audiometry, using non-parametric tests and multiple comparisons at a significance level of 5%. After determining the stricter criteria for hearing recovery, vocal audiometry parameters were added. RESULTS: There was a significant difference between the criteria (p < 0.001 as they were analyzed together. Mild auditory recovery occurred in only 35 (27.6% patients. When speech audiometry was added, only 34 patients (26.8% showed significant improvement. CONCLUSIONS: There is a

  16. A novel PIK3CD C896T mutation detected in bilateral sudden sensorineural hearing loss using next generation sequencing:An indication of primary immunodeficiency

    Institute of Scientific and Technical Information of China (English)

    Jing Zou; Xiangqiang Duan; Guiliang Zheng; Zhen Zhao; Shiyue Chen; Pu Dai; Hongliang Zheng

    2016-01-01

    Objective:To investigate immune-related genetic background in bilateral sudden sensorineural hearing loss (SSNHL). Case report and methods: The case is a 45-year-old man presenting with a 7-year history of bilateral profound SSNHL. Blood biochemical testing demonstrated increased levels of total cholesterol (5.88 mmol/L). Tests for hepatitis B showed a positive antibody against the hepatitis B core antigen. Complement C3 was below the normal value, and complement C4 and IgG were in the lower range of normal values. CT images showed a normal inner ear and vestibular aqueduct but round window membranous ossification on both sides. A total number of 232 immune-associated genes were sequenced using the next generation sequencing technique. Results: Mutations were detected in 5 genes, including the phosphoinositide 3-kinase catalytic subunit delta (PIK3CD), caspase recruitment domain-containing protein 9 (CARD9), complement factor H-related (CFHR2), immunoglobulin lambda-like polypeptide 1 Protein (IGLL1), and transmembrane channel-like gene family 8 (TMC8). In the PIK3CD gene, a C896T substitute in exon 7 was detected. This mutation causes primary immunodeficiency and is an autosomal dominant disease. Conclusion: The PIK3CD C896T mutation responsible for primary immunodeficiency may contribute to the onset of bilateral SSNHL with subsequent rapid progression.

  17. Association between the V Leiden G1691A mutation and sudden sensorineural hearing loss in Italian population: a meta-analysis.

    Science.gov (United States)

    Shu, Jingcheng; Si, Yongfeng; Yin, Shihua; He, Meirong

    2016-09-01

    Epidemiological studies have reported inconsistent findings on the association between the V Leiden G1691A mutation and sudden sensorineural hearing loss (SSNHL) in Italian population. The aim of this meta-analysis was to clarify this association. PubMed, Embase, and the China National Knowledge Infrastructure (CNKI) were searched up to April 1, 2015. We used STATA12.0 to calculate summary odds ratios (ORs) with 95 % confidence intervals (CIs). Four studies including 958 patients were identified. Pooled data showed no significant association between V Leiden G1691A mutation and risk of SSNHL in Italian population: A vs. G (OR = 1.660, 95 % CI 0.428-6.446, P OR = 0.464) and AG vs. GG (OR = 1.680, 95 % CI 0.422-6.688, P OR = 0.462). The present meta-analysis suggests that V Leiden G1691A mutation is not significantly associated with increased risk of SSNHL disease in Italian population. Further large and well-designed studies are needed to confirm this association.

  18. Association of the 4 g/5 g polymorphism of plasminogen activator inhibitor-1 gene with sudden sensorineural hearing loss. A case control study

    Directory of Open Access Journals (Sweden)

    Cho Seong

    2012-06-01

    Full Text Available Abstract Background The 5 G/5 G genotype of PAI-1 polymorphism is linked to decreased plasminogen activator inhibitor-1 (PAI-1 levels and it has been suggested that lower PAI-1 levels may provide protective effects on inflammation, local microcirculatory disturbance, and fibrotic changes, which are likely associated with development of sudden sensorineural hearing loss (SSNHL. Methods The association of the 4 G/5 G PAI-1 polymorphism with the development and clinical outcome of SSNHL is evaluated via a case control study. 103 patients with SSNHL and 113 age and sex-matched controls were enrolled at University of Ferrara, Italy and hearing loss outcome was measured at least 3 months after the onset of hearing loss. DNA was isolated from peripheral blood using the QIAamp kit and the 4 G/5 G polymorphism in the −675 promoter region was genotyped with an allele-specific PCR. Genotype distribution was tested in patients and compared to controls by chi-square and odd-ratio analysis. The codominant and recessive models were used for the multiple logistic regression analyses of the PAI-1 gene allele. Results In this population, 5 G/5 G genotype had a two-time lower frequency in SSNHL patients compared to healthy controls (15.5% vs 30.1% and was associated with decreased odds compared to 4 G/5 G genotype (OR 0.37, 95% CI 0.19-0.75, p = 0.005. In addition, the patients with 5 G/5 G genotype showed a trend of more than 2 times higher ratio of hearing recovery (> 20 dB after systemic corticosteroid treatment compared to 4 G/5 G genotype (OR 2.3, 95% CI 0.32 - 16.83, p = 0.39, suggesting a better clinical outcome. Conclusions The 5 G/5 G genotype of PAI-1 may be associated with a reduced risk of SSNHL in the Italian population.

  19. The efficacy and safety of systemic injection of Ginkgo biloba extract, EGb761, in idiopathic sudden sensorineural hearing loss: a randomized placebo-controlled clinical trial.

    Science.gov (United States)

    Koo, Ja-Won; Chang, Mun Young; Yun, Sung-Cheol; Kim, Tae Su; Kong, Soo-Keun; Chung, Jong Woo; Goh, Eui-Kyung

    2016-09-01

    Steroids are currently the most frequently accepted agents for idiopathic sudden sensorineural hearing loss (ISSNHL). However, the therapeutic effect of steroids is not always satisfactory. In this pilot study, we evaluated whether systemic treatment with Ginkgo biloba extract (EGb761) has an additive therapeutic effect in patients receiving a systemic steroid due to ISSNHL. A multicenter, randomized, double-blind clinical trial was performed. Fifty-six patients with ISSNHL were allocated to either EGb761 or placebo. In both groups, methylprednisolone was administered for 14 days. EGb761 was infused intravenously for 5 days in the EGb761 group, while the same amount of normal saline was infused in the placebo group. For the efficacy evaluation, pure-tone audiometry, speech audiometry, tinnitus handicap inventory (THI) and short form-36 health (SF-36) survey outcomes were obtained before administration and on days 3, 5, 14 and 28 of administration. Twenty-four patients in each group completed the study protocol. There was no difference in hearing loss between the two groups before treatment. At day 28, air conduction threshold values in the placebo and EGb761 groups were 34.63 ± 28.90 and 23.84 ± 25.42 dB, respectively (p = 0.082). Speech discrimination scores in the placebo and EGb761 groups were 69.17 ± 40.89 and 87.48 ± 28.65 %, respectively (p = 0.050). THI and SF-36 scores in the placebo and EGb761 groups were similar. Although a combination of steroid and EGb761 for initial treatment did not show better pure tone threshold, compared with steroid alone, speech discrimination was significantly improved in combination therapy. Further studies will be needed to know if addition of EGb761 actually improves the outcome of ISSNHL treatment. PMID:26559533

  20. Establishment of a Flexible Real-Time Polymerase Chain Reaction-Based Platform for Detecting Prevalent Deafness Mutations Associated with Variable Degree of Sensorineural Hearing Loss in Koreans

    Science.gov (United States)

    Kim, Min Young; Ahn, Soyeon; Oh, Seung-Ha; Song, Ju Hun; Choi, Byung Yoon

    2016-01-01

    Many cutting-edge technologies based on next-generation sequencing (NGS) have been employed to identify candidate variants responsible for sensorineural hearing loss (SNHL). However, these methods have limitations preventing their wide clinical use for primary screening, in that they remain costly and it is not always suitable to analyze massive amounts of data. Several different DNA chips have been developed for screening prevalent mutations at a lower cost. However, most of these platforms do not offer the flexibility to add or remove target mutations, thereby limiting their wider use in a field that requires frequent updates. Therefore, we aimed to establish a simpler and more flexible molecular diagnostic platform based on ethnicity-specific mutation spectrums of SNHL, which would enable bypassing unnecessary filtering steps in a substantial portion of cases. In addition, we expanded the screening platform to cover varying degrees of SNHL. With this aim, we selected 11 variants of 5 genes (GJB2, SLC26A4, MTRNR1, TMPRSS3, and CDH23) showing high prevalence with varying degrees in Koreans and developed the U-TOP™ HL Genotyping Kit, a real-time PCR-based method using the MeltingArray technique and peptide nucleic acid probes. The results of 271 DNA samples with wild type sequences or mutations in homo- or heterozygote form were compared between the U-TOP™ HL Genotyping Kit and Sanger sequencing. The positive and negative predictive values were 100%, and this method showed perfect agreement with Sanger sequencing, with a Kappa value of 1.00. The U-TOP™ HL Genotyping Kit showed excellent performance in detecting varying degrees and phenotypes of SNHL mutations in both homozygote and heterozygote forms, which are highly prevalent in the Korean population. This platform will serve as a useful and cost-effective first-line screening tool for varying degrees of genetic SNHL and facilitate genome-based personalized hearing rehabilitation for the Korean population

  1. Establishment of a Flexible Real-Time Polymerase Chain Reaction-Based Platform for Detecting Prevalent Deafness Mutations Associated with Variable Degree of Sensorineural Hearing Loss in Koreans.

    Science.gov (United States)

    Han, Kyu-Hee; Kim, Ah Reum; Kim, Min Young; Ahn, Soyeon; Oh, Seung-Ha; Song, Ju Hun; Choi, Byung Yoon

    2016-01-01

    Many cutting-edge technologies based on next-generation sequencing (NGS) have been employed to identify candidate variants responsible for sensorineural hearing loss (SNHL). However, these methods have limitations preventing their wide clinical use for primary screening, in that they remain costly and it is not always suitable to analyze massive amounts of data. Several different DNA chips have been developed for screening prevalent mutations at a lower cost. However, most of these platforms do not offer the flexibility to add or remove target mutations, thereby limiting their wider use in a field that requires frequent updates. Therefore, we aimed to establish a simpler and more flexible molecular diagnostic platform based on ethnicity-specific mutation spectrums of SNHL, which would enable bypassing unnecessary filtering steps in a substantial portion of cases. In addition, we expanded the screening platform to cover varying degrees of SNHL. With this aim, we selected 11 variants of 5 genes (GJB2, SLC26A4, MTRNR1, TMPRSS3, and CDH23) showing high prevalence with varying degrees in Koreans and developed the U-TOP™ HL Genotyping Kit, a real-time PCR-based method using the MeltingArray technique and peptide nucleic acid probes. The results of 271 DNA samples with wild type sequences or mutations in homo- or heterozygote form were compared between the U-TOP™ HL Genotyping Kit and Sanger sequencing. The positive and negative predictive values were 100%, and this method showed perfect agreement with Sanger sequencing, with a Kappa value of 1.00. The U-TOP™ HL Genotyping Kit showed excellent performance in detecting varying degrees and phenotypes of SNHL mutations in both homozygote and heterozygote forms, which are highly prevalent in the Korean population. This platform will serve as a useful and cost-effective first-line screening tool for varying degrees of genetic SNHL and facilitate genome-based personalized hearing rehabilitation for the Korean population

  2. The efficacy and safety of systemic injection of Ginkgo biloba extract, EGb761, in idiopathic sudden sensorineural hearing loss: a randomized placebo-controlled clinical trial.

    Science.gov (United States)

    Koo, Ja-Won; Chang, Mun Young; Yun, Sung-Cheol; Kim, Tae Su; Kong, Soo-Keun; Chung, Jong Woo; Goh, Eui-Kyung

    2016-09-01

    Steroids are currently the most frequently accepted agents for idiopathic sudden sensorineural hearing loss (ISSNHL). However, the therapeutic effect of steroids is not always satisfactory. In this pilot study, we evaluated whether systemic treatment with Ginkgo biloba extract (EGb761) has an additive therapeutic effect in patients receiving a systemic steroid due to ISSNHL. A multicenter, randomized, double-blind clinical trial was performed. Fifty-six patients with ISSNHL were allocated to either EGb761 or placebo. In both groups, methylprednisolone was administered for 14 days. EGb761 was infused intravenously for 5 days in the EGb761 group, while the same amount of normal saline was infused in the placebo group. For the efficacy evaluation, pure-tone audiometry, speech audiometry, tinnitus handicap inventory (THI) and short form-36 health (SF-36) survey outcomes were obtained before administration and on days 3, 5, 14 and 28 of administration. Twenty-four patients in each group completed the study protocol. There was no difference in hearing loss between the two groups before treatment. At day 28, air conduction threshold values in the placebo and EGb761 groups were 34.63 ± 28.90 and 23.84 ± 25.42 dB, respectively (p = 0.082). Speech discrimination scores in the placebo and EGb761 groups were 69.17 ± 40.89 and 87.48 ± 28.65 %, respectively (p = 0.050). THI and SF-36 scores in the placebo and EGb761 groups were similar. Although a combination of steroid and EGb761 for initial treatment did not show better pure tone threshold, compared with steroid alone, speech discrimination was significantly improved in combination therapy. Further studies will be needed to know if addition of EGb761 actually improves the outcome of ISSNHL treatment.

  3. 全聋型突发性聋的疗效及预后相关因素分析%Analysis of related prognostic factors and therapeutic effect of sudden sensorineural hearing loss with total hearing loss

    Institute of Scientific and Technical Information of China (English)

    黄晶晶; 周慧群; 陈正侬; 吴雅琴; 时海波

    2016-01-01

    Objective To investigate the therapeutic effect and related prognostic factors of sudden sensorineural hearing loss with total hearing loss. Method A retrospective anaIysis was performed in 33 cases of sudden deafness patients during treatment from Janurary 2013 to August 2014 was conducted. To evaluate the therapeutic effect and analysis related factors of prognosis,all cases were conformed with guidelines for diagnosis and treatment of sudden sensorineural hearing loss by Chinese Medical Association in 2005. Results In 33 cases, the full recover rate was 0, the effective percentage and significant effective percentage were 27.3%(9/33) and 21.2%(7/33),the non-remission rate was 51.5%(17/33). The relationship between age, gender ,time period between onset and therapy, tinnitus ,dizziness was analyzed. There was no significant difference (P>0.05). But the difference between the cases accompanied by systemic disease and not accompanied by systemic disease was significant. (P=0.086). Conclusions The therapeutic effect of sudden sensorineural hearing loss with total hearing loss was poor. In this group, no related prognostic factors was found,but accompanied by systemic disease may be the potential risk factors of poor prognosis.%目的:探讨全聋型突发性耳聋的治疗效果及预后相关因素。方法回顾性分析2013年1月至2014年08月我院收治的全聋型突发性聋33例。遵循2005年中华医学会制定的突发性耳聋诊治指南,评估疗效并进行预后相关因素分析。结果33例患者痊愈率为0,有效率为27.3%(9/33),显效率为21.2%(7/33),无效率为51.5%(17/33)。将年龄、性别、发病至初次就诊时间、有无耳鸣、有无眩晕等指标作为参数,进行疗效相关性检验,均未见统计学意义(P>0.05);但与伴有全身疾病者相比,不伴有全身疾病者具有相对较好疗效的趋势(P=0.086)。结论全聋型突发性聋的总体疗效不佳,

  4. An Auditory-Masking-Threshold-Based Noise Suppression Algorithm GMMSE-AMT[ERB] for Listeners with Sensorineural Hearing Loss

    Directory of Open Access Journals (Sweden)

    Hansen John HL

    2005-01-01

    Full Text Available This study describes a new noise suppression scheme for hearing aid applications based on the auditory masking threshold (AMT in conjunction with a modified generalized minimum mean square error estimator (GMMSE for individual subjects with hearing loss. The representation of cochlear frequency resolution is achieved in terms of auditory filter equivalent rectangular bandwidths (ERBs. Estimation of AMT and spreading functions for masking are implemented in two ways: with normal auditory thresholds and normal auditory filter bandwidths (GMMSE-AMT[ERB]-NH and with elevated thresholds and broader auditory filters characteristic of cochlear hearing loss (GMMSE-AMT[ERB]-HI. Evaluation is performed using speech corpora with objective quality measures (segmental SNR, Itakura-Saito, along with formal listener evaluations of speech quality rating and intelligibility. While no measurable changes in intelligibility occurred, evaluations showed quality improvement with both algorithm implementations. However, the customized formulation based on individual hearing losses was similar in performance to the formulation based on the normal auditory system.

  5. Is sensorineural hearing loss a possible side effect of nasopharyngeal and parotid irradiation? A systematic review of the literature

    International Nuclear Information System (INIS)

    Background and purpose: Little has been published about permanent hearing loss due to radiotherapy, thus making it a rather unknown phenomenon. Therefore, we performed a study of the literature over the last 20 years. Materials and methods: Sixteen relevant clinical studies were found, reporting mostly on nasopharyngeal or parotid gland treatments. Hearing loss was measured using a pure tone audiogram. Studies were assessed using a simple scoring list. Nine studies were used for further analysis. Data on the pure tone audiogram were pooled. Results: Results showed that, especially in the higher frequencies (≥4 kHz), loss can be measured. When data were pooled, in 42±3% of the patients a hearing loss was found of 10 dB or more at 4 kHz. Averaged over all measured frequencies the effect is less prominent but still statistically significant (18±2%). No significant difference between nasopharyngeal and parotid gland treatment was found (P<0.05). Conclusion: Only a few studies, mostly concerning small patient numbers, have investigated hearing damage due to radiotherapy. So far there has been no consensus on the subject. However, in this systematic review we found a significant effect. Dose to the inner ear therefore deserves more attention, especially in dose escalation studies and inverse planning

  6. Effects of hearing aids in the balance, quality of life and fear to fall in elderly people with sensorineural hearing loss

    Directory of Open Access Journals (Sweden)

    Lacerda, Clara Fonseca

    2012-01-01

    Full Text Available Introduction: The aging process provokes structural modifications and functional to it greets, compromising the postural control and central processing. Studies have boarded the necessity to identify to the harmful factors of risk to aged the auditory health and security in stricken aged by auditory deficits and with alterations of balance. Objective: To evaluate the effect of auditory prosthesis in the quality of life, the balance and the fear of fall in aged with bilateral auditory loss. Method: Carried through clinical and experimental study with 56 aged ones with sensorineural auditory loss, submitted to the use of auditory prosthesis of individual sonorous amplification (AASI. The aged ones had answered to the questionnaires of quality of life Short Form Health Survey (SF-36, Falls Efficacy International Scale- (FES-I and the test of Berg Balance Scale (BBS. After 4 months, the aged ones that they adapted to the use of the AASI had been reevaluated. Results: It had 50% of adaptation of the aged ones to the AASI. It was observed that the masculine sex had greater difficulty in adapting to the auditory device and that the variable age, degree of loss, presence of humming and vertigo had not intervened with the adaptation to auditory prosthesis. It had improvement of the quality of life in the dominance of the State General Health (EGS and Functional Capacity (CF and of the humming, as well as the increase of the auto-confidence after adaptation of auditory prosthesis. Conclusion: The use of auditory prosthesis provided the improvement of the domains of the quality of life, what it reflected consequently in one better auto-confidence and in the long run in the reduction of the fear of fall in aged with sensorineural auditory loss.

  7. Fibrinogen is not a prognostic factor for response to HELP-apheresis in sudden sensorineural hearing loss (SSHL).

    Science.gov (United States)

    Berger, T; Kaiser, T; Scholz, M; Bachmann, A; Ceglarek, U; Hesse, G; Hagemeyer, B; Stumvoll, M; Thiery, J; Dietz, A

    2015-12-01

    Higher levels of fibrinogen or cholesterol were associated with improved hearing recovery in SSHL patients after treatment with HELP-apheresis (Heparin-induced extracorporeal LDL precipitation apheresis). The present trial was performed to demonstrate HELP-related effects on relevant metabolic and inflammatory parameters in the context of SSHL treatment. In the framework of a single arm non-controlled trial, we investigated the variation of metabolic and inflammatory parameters using HELP-apheresis for a defined group of 100 patients with SSHL. Based on cut off inclusion criteria (Serum LDL-cholesterol >1.6 g/l and/or fibrinogen >2.0 g/l, SSHL in minimum three frequencies more than 30 dB, time after event not longer than 6 days), the protocol followed a strict time line with one single shot HELP-apheresis and follow-up monitoring including laboratory parameters at six defined time points. If HELP-apheresis could not effect improvement of hearing on day 5, additional corticosteroid treatment was applied. Concentration of anti-inflammatory IL-10 increased while other proinflammatory parameters declined. Serum levels of all measured sterols and apolipoproteins decreased significantly. None of the investigated parameters were suitable to predict hearing improvement of the patients. Levels of fibrinogen and LDL-cholesterol were not prognostic for outcome after HELP-apheresis. A significant (p < 0.001) increase of anti-inflammatory IL-10 after apheresis was notable, while most of the proinflammatory parameters declined. Despite the limited validity of a single arm non-controlled trial, these alterations on immune modulating factors indicate possible secondary pleiotropic effects caused by HELP-apheresis.

  8. Vestibular Evoked Myogenic Potential Produced by Bone-Conducted Stimuli: A Study on its Basics and Clinical Applications in Patients With Conductive and Sensorineural Hearing Loss and a Group With Vestibular Schawannoma

    Directory of Open Access Journals (Sweden)

    Parvane Mahdi

    2013-06-01

    Full Text Available Introduction: Vestibular evoked myogenic potential (VEMP has recently been broadly studied in vestibular disorders. As it is evoked by loud sound stimulation, even mild conductive hearing loss may affect VEMP results. Bone-conducted (BC stimulus is an alternative stimulation for evoking this response. This study aims to assess the characteristics of BC-VEMP in different groups of patients.   Materials and Methods: We performed a cross sectional analysis on 20 healthy volunteers with normal pure-tone audiometry as a control group; and on a group of patients consisted of 20 participants with conductive hearing loss, five with bilateral sensorineural hearing loss and four with vestibular schawannoma. AC and BC-VEMP were performed in all participants.   Results: In control group the VEMP responses to both kinds of stimuli had an acceptable morphology and consisted of p13 and n23 waves. Latency value of these main components in each type of stimulus was not significantly different (P>0.05. However, the mean amplitude was larger in BC modality than AC stimulation (P=0.025. In the group with conductive hearing loss, the VEMP response was absent in fifteen (46.87% of the 32 ears using the AC method, whereas all (100% displayed positive elicitability of VEMP by BC method. Normal VEMP responses in both stimuli were evoked in all patients with sensorineural hearing loss. In patients with unilateral vestibular schwannomas (VS, 2 (50.00% had neither AC-VEMP nor BC-VEMP. Conclusion:  Auditory stimuli delivered by bone conduction can evoke VEMP response. These responses are of vestibular origin and can be used in vestibular evaluation of patients with conductive hearing loss.

  9. 地震后突发性感音神经性听力损失发病情况调查%Sudden sensorineural hearing loss after earthquakes

    Institute of Scientific and Technical Information of China (English)

    刘蓉蓉; 姬长友; 肖雅

    2012-01-01

    目的 探讨地震后(Sudden sensorineural hearing loss,SSNHL)SSNHL的发病规律,及其与睡眠障碍(Sleep disorders,SD)之间的关系.方法 从汶川及玉树两次地震后大坪医院收治的1328例伤病员中遴选1050例轻伤类伤病员作为研究对象,其中男性616例,女性434例.按照年龄分为5组,分别观察不同性别及年龄段伤病员SSNHL及SD的发病规律,以及SSNHL和SD的相关性.结果 1050例研究对象中,女性SSNHL发病率(12.9%)明显高于男性(6.66%)(P=0.001< 0.01).97例SSNHL患者中,低龄者(18~45岁)重度听力损失的发病率(21.67%)明显高于高龄者(5.41%)(P=0.031<0.05).1050例伤病员中,男性和女性SD发病率分别为28.57%及24.65%,无显著性差异(P=0.159>0.05).SD患者SSNHL的发病率(22.97%)明显高于非SD者(4.17%)(P=0.000<<0.01).女性SSNHL患者SD的发病率(73.21%)明显高于男性(31.71%)(P=0.00<<0.01).97例SSNHL病人中,第V组SD发病率(83.33%)明显高于其余各组(P=0.039< 0.05).结论 地震后SSNHL发病率较高.老年人及女性高发.中青年发病率较低但病情重的趋势明显.SD可能与SSNHL的发生发展有关.%Objective To investigate patterns of sudden sensorineural hearing loss (SSNHL) after earthquakes and its relationship with sleep disorders (SD). Methods From the 1328 patients treated at Daping Hospital after Wenchuan and Yushu earthquakes, 1050 (616 males and 434 females) with mild injuries were included in this study. They were divided into five groups based upon their ages to study correlations between SSNHL and age, sex and SD. Results The incidence of SSNHL was higher in female (12.9%) than in male (6.6%) ( P = 0.001 0.05). However, the SSNHL incidence in SD patients (22.97%)was higher than that in other patients(4.17%)(P = 0.000 ?0.01). The incidence of SSNHL in female SD patients(73.21%)was also higher than in male SD patients(31.71%)(P = 0.00 << 0.01). In the 97 SSNHL cases, SD incidence of Group

  10. Nontumorous enlargement of the internal auditory canal. A risk factor for sensorineural hearing loss? A high resolution CT-study

    Energy Technology Data Exchange (ETDEWEB)

    Stimmer, H.; Rummeny, E.J. [Technical University Munich, Klinikum rechts der Isar (Germany). Dept. of Radiology; Niedermeyer, H.P. [Technical University Munich, Klinikum rechts der Isar (Germany). ENT-Clinic; Kehl, V. [Technical University Munich, Klinikum rechts der Isar (Germany). Inst. for Medical Statistics and Epidemiology

    2015-06-15

    First aim of the study was to define normal shape and diameter of the internal auditory canal (IAC). In the second part the clinical relevance of IAC-enlargement was analyzed, considering also lesions of the subtle structures at the fundus of the internal auditory canal. 440 high resolution CT-scans of the temporal bone were used for retrospective analysis of the internal auditory canal and its fundus region. The mean value of the IAC diameter in axial and coronal plane was determined. In 20 of 440 patients IAC enlargement was found. In the group with pronounced enlargement (3fold SD) nearly all patients suffered from hearing impairment. In some of them we found structural abnormalities near the IAC fundus in the CSF/perilymph border zone. A new CT-based definition of normal shape and diameter of the internal auditory canal is presented. There is some evidence that a pathologic transmission of CSF-pressure in case of IAC-enlargement and/or abnormal fistulous communications could play an important role in the pathophysiology of hearing loss.

  11. The significance of a hypoplastic bony canal for the cochlear nerve in patients with sensorineural hearing loss: CT and MRI findings

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Yoon Jung; Park, Sang Yoo; Kim, Myung Soon; Sung, Ki Jun [College of Medicine, Yonsei Univ., Wonju (Korea, Republic of)

    2004-04-01

    The purpose of this study is to evaluate the significance of the hypoplastic canal for the cochlear nerve in patients with sensorineural hearing loss (SNHL) and the relationship between the hypoplastic bony canal and aplasia or hypoplasia of the cochlear nerve. A retrospective review of high resolution temporal CT(HRCT) and MRI findings was conducted. The narrow bony canal of the cochlear nerve and the relative size of the internal auditory canal were correlated with the cochlear nerve deficiency on MRI. The comparative size of the component nerves (facial, cochlear, superior vestibular, inferior vestibular nerve), and the relative size of the internal auditory canal and the bony canal of the cochlear nerve were measured. The clinical history and the results of the clinical examination were reviewed for each patient. High resolution MRI showed aplasia of the common vestibulocochlear nerve in one patient and a deficiency of the cochlear nerve in 9 patients. These abnormalities occurred in association with a prominent narrowing of the canal for the cochlear nerve and a stenosis of the internal auditory canal, which was observed on temporal bone CT in 9 patients with congenital SNHL. Three patients had normal IAC, despite the presence of a hypoplastic cochlear nerve on the side on which they had SNHL. In one patient, the narrowing of the canal for the cochlear nerve and internal auditory canal were not found to be associated with acquired SNHL. The hypoplastic bony canal for the cochlear nerve might be more highly indicative of congenital cochlear nerve deficiency than that of the narrow internal auditory canal, and the position of the crista falciformis should also be carefully.

  12. The effect of dexamethasone in different application on treatment of sudden sensorineural hearing loss%地塞米松不同给药方式治疗突发性聋的疗效观察

    Institute of Scientific and Technical Information of China (English)

    黄俊昌; 任忠怀

    2012-01-01

    目的:探讨地塞米松不同给药方式治疗突发性聋的疗效.方法:回顾性分析100例突发性聋患者,将其分为2组,A组(50例)全身静脉注射地塞米松,B组(50例)鼓室内注射地塞米松.结果:A、B组治疗总有效率分别为66%、68%,差异无统计学意义(P>0.05).结论:不管全身方式给药,还是局部鼓室给药,使用地塞米松治疗突发性聋的疗效相仿.%Objective:To investigate the effect of dexamethasone through different methods of administration in treatment of sudden sensorineural hearing loss. Method:One hundred cases of sudden sensorineural hearing loss were retrospectively studied, in which patients were divided into 2 groups as A and B. The cases were treated with dexamethasone intravenous injection in A group and intratympanic application in B group. Result: The total effective rate was 66. 00% in A group and 68. 00% in B group. The difference between the total effective rate in group A and B did not reach significance in statisties(P>0. 05). Conclusion:The effect of dexamethasone intravenous injection and intratympanic application on treatment of sudden sensorineural hearing loss has no difference.

  13. Acute unilateral hearing loss as an unusual presentation of cholesteatoma

    Directory of Open Access Journals (Sweden)

    Bickerton Richard C

    2005-09-01

    Full Text Available Abstract Background Cholesteatomas are epithelial cysts that contain desquamated keratin. Patients commonly present with progressive hearing loss and a chronically discharging ear. We report an unusual presentation of the disease with an acute hearing loss suffered immediately after prolonged use of a pneumatic drill. Case presentation A 41 year old man with no previous history of ear problems presented with a sudden loss of hearing in his right ear immediately following the prolonged use of a pneumatic drill on concrete. The cause was found to be a fractured long process of incus which had been eroded by the presence of an attic cholesteatoma. A tympanomastoidectomy and ossiculoplasty was performed with good result. Conclusion Cholesteatomas may be asymptomatic and insidious in their onset. This case illustrates the point that an indolent disease such as this may present in unusual ways and the clinician must always have a high index of suspicion combined with thorough assessment and examination of every patient.

  14. 影响突发性聋疗效的相关因素研究%Analysis of prognostic factors for sudden sensorineural hearing loss

    Institute of Scientific and Technical Information of China (English)

    王平; 盛迎涛; 张小云

    2013-01-01

    目的:探讨突发性聋预后的相关因素,指导其预后判断。方法回顾性分析2007年10月~2012年7月710例(748耳)突发性聋患者,应用有序Logistic回归分析,筛选与突发性聋预后相关的因素,对于有统计学意义的因素用非参数检验再次验证,以指导预后分析。结果年龄、病程、伴眩晕症状、治疗前耳聋程度、伴糖尿病与疗效有相关性;性别、耳聋侧别、伴高血压与疗效无相关性;病程长短与疗效有统计学意义(P>0.05);不伴眩晕的患者治疗有效率要明显高于伴眩晕的患者(P﹤0.05);糖尿病患者与非糖尿病患者的有效率比较有统计学意义(P﹤0.05);初诊听阈程度与疗效差异有统计学意义(P﹤0.05)。结论影响突发性聋预后的因素有年龄、病程、伴发症状、伴糖尿病、治疗前耳聋程度。%Objective To analysis the prognostic factors of the sudden sensorineural hearing loss(SHL), and to predict the prognosis of patient with SHL precisely. Method 710 cases (748 ears) with SHL were reviewed retrospectively during October 2007 to July 2012. Possible influence factors were analyzed with logistic stepwise regression to investigate the correlation with prognosis.All verified influence factors were analyzed with non-parametric statistics. Result The prognosis of SHL related to age, the trouble time before treatment,concurrent vertigo, diabetes,degree of hearing loss, but not to gender, trouble ear and hypertension. With increasing of age,the prognosis of SHL becomes poor. Less time elapsed before treatment and the result became better. Compared with patients suffer from vertigo, patients without vertigo obtain a better outcome (P﹤0.05). Furthermore, about comparison with the low, midst, severe and profound hearing loss, statistical different exists. Conclusion The factor of age, the course before treatment, concurrent vertigo, diabetes, degree of hearing loss are correlated with

  15. 鼓室内注射地塞米松联合强的松治疗突发性聋33例%Efficacy of intratympanic dexamethasone combined with prednisone on idiopathic sudden sensorineural hearing loss

    Institute of Scientific and Technical Information of China (English)

    李鹏; 张奕; 符秋养; 谢景华; 梁勇

    2014-01-01

    Objective To evaluate the therapeutic efficacy of intratympanic dexamethasone injections combined with prednisone in patients with idiopathic sudden sensorineural hearing loss. Methods A total of 71 patients diagnosed with sudden hearing loss were treated with intratympanic dexamethasone injections plus prednisone (B group) or prednisone alone (A group). Hearing was evaluated by pure tone audiogram performed before initial treatment and at 4 weeks following the final treatment. Results The total recovery rate after the treatment was 81.8% in the B group and 55.3% in the A group. The diflference between two groups was statistically significant (P < 0.05). Conclusion The present study suggests that sudden sensorineural hearing loss patients treated with intratympanic dexamethasone combined with prednisone have a higher likelihood of hearing recovery than those treated with prednisone alone.%目的:观察鼓室内注射地塞米松联合强的松治疗突发性聋的疗效。方法:71例(71耳)突发性聋患者分成2组, A 组38例(38耳)口服强的松, B 组33例(33耳)在 A 组用药的基础上,加用鼓室注射地塞米松治疗,4周后比较两组疗效。结果:B 组总有效率(81.8%)显著高于 A 组(55.3%),差异有统计学意义(P <0.05)。结论:鼓室注射地塞米松联合强的松治疗突发性聋疗效显著。

  16. A case of bilateral sudden hearing loss and tinnitus after salicylate intoxication.

    Science.gov (United States)

    Kim, Sang Min; Jo, Joon-Man; Baek, Moo Jin; Jung, Kyu Hwan

    2013-04-01

    Salicylate, the active ingredient of aspirin can cause sensorineural hearing loss and tinnitus when plasma concentrations reach a critical level. The ototoxic mechanisms of salicylate remain unclear but hearing and tinnitus usually recovers a few days after intoxication. There have been few reports of salicylate-induced ototoxicity in Korea, and the majority is caused by a low dose of aspirin. Herein, we report a case of sudden hearing loss and tinnitus after acute salicylate intoxication and review recent updates on salicylate ototoxicity.

  17. "Audiometric studies in 53 cases with sudden sensorineural hearing loss:can we suggest an algorithm for treatment? "

    Directory of Open Access Journals (Sweden)

    Nemati Sh

    2007-08-01

    Full Text Available Background: Sudden sensorinueural hearing loss (SSNHL is a baffling condition for patients, and its etiology, audiologic characteristics, prognostic factors, and treatment are still controversial. Methods: In this prospective study, we performed pure tone audiometry (PTA, impedance acoustics (IA, auditory brainstem responses (ABR, otoacoustic emissions (OAE, and transiently evoked otoacoustic emissions (TEOAE before beginning treatment for 53 patients with SSNHL. We then entered each patient, randomly and alternately, in one of two treatment groups: oral steroids + acyclovir vs. intravenous urographin. Results: In 22 (41.5% of the 53 patients (22 female, 31 male, we found negative or no signal to noise ratio and overall correlation in TEOAE. Furthermore, 26 cases (49% had positive overall correlations less than 50%, and five cases (4.4% had overall correlations >50%. Although 15 cases (28.3% responded well, 20 cases (37.7% showed only a partial response, and 18 cases (33.9% had poor or no response to our treatment. The mean value for overall correlation in the three subgroups of patients (no response, partial response, and complete response was -3.5% (±1/16%, + 11% (±1.99%, and +36.6% (±3.07% respectively (P = 0.01. From 52 cases, 20 had no reproducible wave in ABR (38.5%, three cases had abnormal ABR with normal OAE, all of which responded completely to treatments. Thirteen cases had abnormal ABR and OAE, none of which responded to treatment, and six cases had normal ABR with abnormal OAE, which often responded to treatment. Conclusions: ABR and OAE may be useful in the diagnosis of SSNHL and determining the site of such lesions as ischemia or neuropathy. The overall correlation (and S/N ratio in TEOAE is a valuable prognostic factor in SSNHL.

  18. The frequency of congenital long QT syndrome based on new formula in children with sensori-neural hearing loss

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    Arezoo Khosravi

    2015-01-01

    Full Text Available Introduction: Long QT syndrome (LQTS is a repolarization cardiac disorder that can lead to syncope, cardiac arrest and sudden death in apparently healthy individuals. The congenital type can be accompanied with congenital sensory-neural deafness (Jervell-Lang-Nielsen syndrome. Although there are limited studies assessed the frequency of LQTS in these children in developed countries, regarding introducing the new formula, it is necessary to re-evaluate the frequency of this syndrome. Materials and Methods: This cross-sectional and descriptive study was done on 203 patients with congenital sensory-neural hearing loss (SNHL that had cochlear implant surgery in Baqiyatallah cochlear implant center from 2008 to 2012. Corrected QT was calculated with this formula: QTC = QT + 1.75 (heart rate-60 Patients with QTC > 460 ms, were categorized in four groups: Long QT: QT > 460, Borderline: 440 470 and very markedly: >500. Also, cardiac arrhythmias or arrest were evaluated in patients during cochlear implant surgery and in the postoperative recovery period. Result: Prevalence of LQTS in patients was 12.32% (25 patients. Prevalence of markedly long QT and very markedly long QT were 8.87% (18 patients and 2.46% (5 patients respectively. The prevalence of borderline group was 14.29% (29 patients. None of the patients during or after surgery were affected by cardiac arrhythmias or arrest. Conclusion: This study showed higher prevalence of LQTS in patients with SNHL than the normal population, and we suggest that all patients with congenital deafness should be screen for LQTS.

  19. Diagnosis and treatment of acute hearing loss%急性听力损失的诊断与治疗

    Institute of Scientific and Technical Information of China (English)

    孙建军; 刁明芳

    2007-01-01

    急性听力损失(acute hearing loss,AHL)表现为在数小时至3d、至少3个连续频率听力下降超过30dB的听力损失。突发性感音神经性聋(sudden sensorineural hearing loss,SSNHL)指突然发生的,可在数分钟、数小时或3d以内,原因不明的感音神经性听力损失,至少在相连的2个频率听力下降20dB以上。国外的文献对SSNHL的定义为:突然发生的原因不明的感音神经性听力损失,在72h内至少3个相连频率的听力下降20dB或30dB以上。

  20. A comparison of inner ear imaging features at different time points of sudden sensorineural hearing loss with three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging.

    Science.gov (United States)

    Zhu, Honglei; Ou, Yongkang; Fu, Jia; Zhang, Ya; Xiong, Hao; Xu, Yaodong

    2015-10-01

    It has been reported that about half of patients with sudden sensorineural hearing loss (SSNHL) show high signals in the affected inner ear on three-dimensional, fluid-attenuated inversion recovery magnetic resonance imaging (3D-FLAIR MRI). These signals may reflect minor hemorrhage or an increased concentration of protein in the inner ear, which has passed through blood vessels with increased permeability. Our objective was to compare the positive ratio of the high signal in affected inner ears at different time points to determine the suitable imaging time point for 3D-FLAIR MRI in SSNHL. 3D-FLAIR MRI images were taken at three times, precontrast and approximately 10 min and 4 h after intravenous injection of a single dose of gadodiamide (Gd) (0.1 mmol/kg), in 46 patients with SNHL. We compared the positive findings of the high signals in the inner ear of patients with SNHL as well as the signal intensity ratio (SIR) between the affected cochleae and unaffected cochleae at three time points. The positive ratios of the high signals in the affected inner ear at the time points of precontrast and 10 min and 4 h after the intravenous Gd injection were 26.1, 32.6, and 41.3%, respectively. The high signal intensity ratios of affected inner ears at the three time points were 1.28, 1.31, and 1.48, respectively. The difference between the positive ratios precontrast and at 10 min after the intravenous Gd injection was statistically significant (P = 0.006); the differences between the positive ratios at 4 h after the intravenous Gd injection and precontrast and between the ratios at 4 h and 10 min after the intravenous Gd injection were not statistically significant. The time effects of the median value of SIR were not significant (P = 0.064). We do not recommend 4 h after intravenous Gd injection as a time point to image the inner ear in SNHL. We believe that imaging precontrast and at 10 min after the intravenous Gd injection are suitable time points.

  1. Steroids for sudden sensorineural hearing loss: a meta-analysis%类固醇激素治疗突发性聋的Meta分析

    Institute of Scientific and Technical Information of China (English)

    杜婉; 马彬; 郭玉芬; 杨克虎

    2010-01-01

    目的 系统评价类固醇激素治疗突发性聋(sudden sensorineural hearing loss,SSNHL)的有效性和安全性.方法 计算机检索Cochrane Library(2009年第4期)、PubMed(1966~2009.11)、EMBASE(1974~2009.11)、CBM(1978~2009.11)、CNKI(1994~2009.11)、VIP(1989~2009.11)和万方数据(1997~2009.11).纳入类固醇激素治疗SSNHL的随机对照和半随机对照试验,按照Cochrane Handbook 5.0进行严格的质量评估,采用RevMan 5.0.2软件进行Meta分析.结果 共纳入4个RCTs,3个Quasi-RCT,包括665例患者.Meta分析结果显示:地塞米松可明显提高即刻(治疗结束后6 d)听力恢复率(OR:2.60,P=0.00,95%CI:1.78-3.80),并可改善患者耳鸣的发生,但在治疗结束后3个月的听力恢复率和言语识别方面,差异均无统计学意义;泼尼松对治疗后即刻(治疗结束后6 d)和治疗结束后1个月的听力恢复率(分别为OR:0.86,P=0.86,95%CI:0.15-5.00,和OR:0.89,P=0.92,95%CI:0.10-7.86)差异均无统计学意义.结论 地塞米松能显著提高听力恢复率,改善耳鸣的发生.但限于纳入研究的局限性,地塞米松对治疗结束后3个月的听力恢复率和言语识别,以及泼尼松在听力恢复率、耳鸣发生和言语识别方面的疗效尚不确定.

  2. 浅析助听器远程验配和现场验配现状%The Analysis of Remote and Local Hearing Aid Fitting for Sensorineural Deafness

    Institute of Scientific and Technical Information of China (English)

    张晟; 刘璟

    2015-01-01

    目的:发现给感音神经性聋患者验配助听器过程中存在的问题,初步分析助听器验配成功率较低的原因,以达到提高基层医院的验配成功率的目的。方法通过对比感音神经性耳聋患者远程专业技师验配(38例)和现场专业技师验配助听器(40例)的成功率,分析助听器验配失败的原因。结果我院远程验配助听器和现场验配助听器成功率均较低,且远程验配助听器成功率要低于现场验配助听器成功率,但不具有统计学意义(P>0.05)。结论大多数感音神经性耳聋患者听力下降只有通过听力补偿的方式得到改善。远程专业技师验配助听器技术对推进我国基层医院的规范验配助听器起到了积极促进的作用。通过总结我院远程专业技师验配和现场专业技师验配助听器的工作经验,总结我院助听器验配成功率较低的原因,以更好地开展验配助听器的工作。%ObjectiveFound to sensorineural deafness were present during the hearing aid iftting problems, preliminary analysis of low power hearing aids dubbed the reasons as to improve primary hospital examination of paired power purposes.Methods Remote professional technicians fitting (38 cases) by comparing sensorineural deafness and hearing aid iftting site professional technicians (40) success rate, analyze the causes of hearing aid iftting failure.ResultsThe success rate of local and remote hearing aid iftting are both low, Furthermore the latter is more low at our hospital, but this phenomenon is not statistical signiifcance(P>0.05).Conclusion Most of the sensorineural deafness can not be cured entirely, this illness can be gradually improved only through some hearing compensating facility. The remote hearing aid iftting will have a positive role on improving the normative operation level in basic hospital. We attempt to find the low success rate of hearing aid iftting by compare the results

  3. 不同听力损失类型及年龄突发性耳聋患者的治疗效果分析%Treatment Outcomes Analysis in Sudden Sensorineural Hearing Loss among Different Ages and Audiological Types

    Institute of Scientific and Technical Information of China (English)

    樊新; 修世国

    2015-01-01

    目的:探讨突发性耳聋患者的不同听力损失类型和年龄与疗效的相关性。方法90例(98耳)突发性耳聋患者根据年龄不同分为两组:青中年组15-60岁(42例,47耳)和老年组60-81岁(48例,51耳),分析比较不同听力损失类型和年龄突发性耳聋患者的治疗效果。结果不同听力损失类型突发性耳聋患者的疗效分别为低频型85.71%、高频型65.52%、平坦和全聋型80.49%,低频型或平坦和全聋型分别与高频型比较差异均有统计学意义(P<0.05),低频型与平坦和全聋型比较无明显差异(P>0.05);青中年组与老年组的疗效比较差异有统计学意义(P<0.05)。结论低频型的疗效最好,平坦型及全频型其次,高频型的疗效最差,临床上可依据听力损失类型判断疗效。%Objective To discuss the correlation between different audiological types and different ages in Sudden Sensorineu-ral Hearing Loss.Methods Analysis treatment results in patients of different ages with sudden sensorineural hearing loss of different audiology patterns. Methods Treatment outcomes in relation to age and audiometric pattern were reviewed in 90 patients (98ears) with sudden sensorineural hearing loss who were divided into three age groups:15—60 years (42patients,47 ears),60—81years (48 pa-tients,51 ears).Result Effective rates of low frequency hearing loss、high frequency hearing loss、All—frequency hearing loss were 85.71%、65.52%and 80.49%,The differences were statistically significant.Conclusion Low frequency hearing loss responded best to treatment, followed by all-frequency hearing loss, whereas high frequency hearing loss yielded poorest response,we can predict prognosis According to different audiological types.

  4. 突发性聋伴耳鸣患者治疗前耳鸣性状分析%Analysis of Tinnitus Characteristics in the Idiopathic Sudden Sensorineural Hearing Loss Patients

    Institute of Scientific and Technical Information of China (English)

    张帅; 周莲; 冯宁宇; 郑虹

    2011-01-01

    Objective To evaluate the distribution and characteristics of tinnitus in idiopathic sudden sensorineural hearing loss(ISSHL) patients , the relationship with hearing loss, and to explore appropriate evaluating method of tinnitus to the ISSHL patients. Methods 56 patients(56 ears) were diagnosed as idiopathic sudden sensorineural hearing loss accompanied with tinnitus and the data were analyzed accordingly. Results ①The frequencies of tinnitus match focus in the hearing loss frequencies and tinnitus mostly matched was narrow band noise. The tinnitus loudness spread wildly. ②The tinnitus subjective distress scales have no obvious correlation with the tinnitus types,loudness of tinnitus, or hearing loss. The tinnitus type match has no obvious relationship with hearing loss. Conclusion Every patient has different tolerance capacity to tinnitus, tinnitus match combine with subjective scale evaluation are more appropriate method.%目的 分析突发性聋伴耳鸣患者的耳鸣性状及其与听力损失之间的关系,探讨耳鸣对患者影响的评估方法.方法 对56例(56耳)突发性聋伴耳鸣患者行听力检测和耳鸣主观分级(评估)及耳鸣匹配检查.结果 ①耳鸣匹配的频率集中于听力损失的频率范围,耳鸣匹配的类型主要为窄带噪声,匹配响度分布较为广泛;②耳鸣主观分级与匹配类型,响度、听力损失程度之间无明显关系;听力损失程度与耳鸣匹配类型无明显关系.结论 突发性聋伴耳鸣患者耳鸣主观分级具有个体差异,与耳鸣匹配共同评估更能反映出耳鸣对患者的影响.

  5. Avaliação do Voice Handicap Index em pacientes com perda auditiva neurossensorial bilateral a partir de grau moderado Voice Handicap Index evaluation in patients with moderate to profound bilateral sensorineural hearing loss

    Directory of Open Access Journals (Sweden)

    Felipe Barbosa Madeira

    2010-02-01

    Full Text Available A produção da voz e da fala é processo que envolve mecanismos reguladores dependentes da audição. As alterações vocais em pacientes com perda auditiva ainda não foram avaliadas quanto ao grau subjetivo de incapacidade que trazem a este grupo. OBJETIVO: Comparar os resultados do Voice Handicap Index (VHI em pacientes com e sem perda auditiva neurossensorial bilateral a partir de grau moderado. FORMA DE ESTUDO: Estudo transversal controlado. MATERIAL E MÉTODO: Foram avaliados 76 pacientes adultos (38 com e 38 sem perda auditiva entre 19 e 59 anos, atendidos em serviço terciário de otorrinolaringologia mediante preenchimento do VHI. RESULTADOS: A mediana da pontuação total do VHI obtida no grupo de pacientes e controle foi de 23,5 e 4,0, respectivamente (p = 0,000. Diferenças significativas entre os dois grupos também foram conseguidas nas medianas dos subitens funcional, físico e emocional do VHI (p = 0,000. CONCLUSÃO: Os resultados obtidos permitem verificar a maior desvantagem social e econômica conforme avaliada pelo VHI em pacientes com perda auditiva neurossensorial bilateral a partir de grau moderado.Voice and speech are regulated by hearing. Vocal disorders in patients with hearing loss have not been evaluated yet as to the subjective degree of disability they cause in this group. AIM: to compare the results of the Voice Handicap Index (VHI obtained for patients with normal hearing and moderate to profound bilateral sensorineural hearing loss. STUDY DESIGN: Controlled, cross-sectional. MATERIALS AND METHODS: A total of 76 adult patients being treated on a University Otolaryngology center were enrolled (38 with and 38 without hearing loss, ages ranging between 19 and 59 years, were asked to complete the Portuguese version of the VHI. RESULTS: Total VHI score median values obtained were 23.5 and 4.0 for the study and control groups, respectively (p = 0.000. Significant differences between the two groups were found for all

  6. Mutational screening in patients with profound sensorineural hearing loss and neurodevelopmental delay: Description of a novel m.3861A > C mitochondrial mutation in the MT-ND1 gene.

    Science.gov (United States)

    Ammar, Marwa; Tabebi, Mouna; Sfaihi, Lamia; Alila-Fersi, Olfa; Maalej, Marwa; Felhi, Rahma; Chabchoub, Imen; Keskes, Leila; Hachicha, Mongia; Fakhfakh, Faiza; Mkaouar-Rebai, Emna

    2016-06-10

    Mitochondrial diseases caused by mitochondrial dysfunction are a clinically and genetically, heterogeneous group of disorders involving multiple organs, particularly tissues with high-energy demand. Hearing loss is a recognized symptom of a number of mitochondrial diseases and can result from neuronal or cochlear dysfunction. The tissue affected in this pathology is most probably the cochlear hair cells, which are essential for hearing function since they are responsible for maintaining the ionic gradients necessary for sound signal transduction. Several mitochondrial DNA mutations have been associated with hearing loss and since mitochondria are crucial for the cellular energy supply in many tissues, most of these mtDNA mutations affect several tissues and will cause syndromic hearing loss. In the present study, we described 2 patients with sensorineural hearing loss and neurodevelopmental delay in whom we tested mitochondrial genes described to be associated with syndromic hearing loss. One of these patients showed a novel heteroplasmic mitochondrial mutation m.3861A > C (W185C) which lead to a loss of stability of the ND1 protein since it created a new hydrogen bund between the unique created cystein C185 and the A182 residue. In the second patient, we detected two novel heteroplasmic variations m.12350C > A (T5N) and m.14351T > C (E108G) respectively in the MT-ND5 and the MT-ND6 genes. The TopPred II prediction for the E108G variation revealed a decrease of the hydrophobicity in the mutated MT-ND6. PMID:27155156

  7. 以突发性聋为首发症状的听神经瘤临床特征分析%A clinical analysis for sudden sensorineural hearing loss with acoustic neurinoma

    Institute of Scientific and Technical Information of China (English)

    龚麒麟; 周爱东; 林昶

    2013-01-01

    目的 分析突发性聋(简称突聋)患者中听神经瘤的发病情况及临床特征.方法 回顾性分析2008年1月至2012年8月467例突聋患者的临床资料,探讨其中确诊为听神经瘤患者的临床特征.结果 467例突聋患者中确诊听神经瘤9例(9耳),占1.93%;男2例,女7例,年龄28~57岁.其中7例伴有耳鸣,3例伴有眩晕.9例患者中,听力损失轻度2例,中度2例,重度4例,极重度1例;听力曲线类型呈低频下降型1例,中频下降型2例,高频下降型1例,平坦型4例,全聋型1例.8例ABR异常,9例患耳患侧镫骨肌反射均未引出,7例健耳患侧镫骨肌反射未引出.肿瘤大小Koos分级,I级7例,Ⅱ级1例,Ⅳ级1例.7例小肿瘤患者采取观察治疗策略,并短期(3~5 d)应用糖皮质激素和改善内耳微循环药物治疗,其中4例听力有所恢复.结论 部分听神经瘤患者的首发症状可表现为突聋,尤其是局限于内听道的小肿瘤.突聋患者应常规行ABR和MRI检查,以免漏诊听神经瘤.针对以突聋为首发症状的小听神经瘤患者,可按突聋给予相应治疗以保护听力.%Objective Retrospectively analyzed the clinical data of sudden sensorineural hearing loss with acoustic neuroma.Methods The clinical data of 467 cases with sudden sensorineural hearing loss were collected between Jan,2008 and Aug,2012.Discussed the clinical data which were diagnosed as acoustic neuroma.Results In 467 cases of sudden sensorineural hearing loss,nine cases were diagnosed as acoustic neuromas(9 ears,1.93%),two males and seven females,with a age range of 28 to 57 years.Among them,seven cases accompanied with tinnitus,seven cases with vertigo.The hearing results in nine cases,two cases were found to be mild,two were moderate,four were severe,and one was profound hearling loss respectively.Hearing was classified into five types according to audiogram shape (1 of up-sloping,1 of down-sloping,2 of mid-frequency,1 of profound loss,4 of flat audiogram

  8. 73例波动性感音神经性聋病因及临床特点分析%Etiologies and clinical characteristics in 73 cases of fluctuating sensorineural hearing loss

    Institute of Scientific and Technical Information of China (English)

    曾祥丽; 李鹏; 李永奇; 岑锦添; 黎志成; 王树芳; 张革化

    2012-01-01

    Objective To report common etiologies,clinical characteristics and causes of erroneous and missed diagnoses in a series of cases of fluctuating sensorineural hearing loss (FSNHL). Methods The authors retrospectively -analyzed clinical data, audiology and radiology test results of 73 cases with FSNHL. Results ① Etiologies in the 73 cases included: low-tone sensorineural hearing loss (LSNHL, 21/73, 29%), Meniere disease (MD, 17/73, 23%), inner ear malforma-tion(12/73, 16%), delayed endolymphatic hydrops (DEH, 8/73,11%), autoimmune sensorineural hearing loss (ASNHL, 5/ 73, 7%), early stage acoustic neurinoma(4/73, 6%), noise-induced hearing loss(3/73,4%)and unkoown etiologies(3/73, 4%). No auditory neuropathy, perilymph fistula or vascular abnormalities was found in this group of patients. ② Hearing fluctuated only in the low frequency range in LSNHL and early stage MD eases, and only in the high frequency range in early stage acoustic neurinoma and noise-induced hearing loss cases.ASNHL and bilateral inner ear anomalies often showed symmetrical sensorineural hearing loss. ③ Causes of erroneous and missed diagnosis: Symmetrical enlarged vestibule abnormalities could show symmetrical and progressive sensorineural hearing loss attacks in adulthood. Most such cases could be identified by the precipitating factors of attacks, including sudden rises of intracranial or abdominal pressures. Radiology was helpful to differentiate these cases from those of ASNHL; Unilateral high-frequency hearing fluctuation often represented early stage acoustic neurinoma, which could be picked up by enhanced MRI as a routine test to avoid missed diagnosis. Conclusion FSNHLinvolves numerous etiologies. Correct diagnosis depends on not only history, symptomatology and audiology features, but also knowing the precipitating and occupational environment factors.%目的 探讨波动性感音神经性聋(FSNHL)的病因及其相应的临床特点,分析引起误诊及漏诊的原因,为

  9. 脂联素和Hs-CRP在突发性耳聋中的临床意义%Determination of serum adiponectin and high-sensitivity C-reative protein in patients with idiopathic sudden sensorineural hearing loss and its clinical significance

    Institute of Scientific and Technical Information of China (English)

    王霞; 牛善利; 马惠平; 张冬梅; 张敏

    2009-01-01

    Objective To study the role and clinical significance of serum adiponectin and high-sensitivity C-reative protein(Hs-CRP)in idiopathic sudden sensorineural hearing loss by measuring the change of their levels in the patients with idiopathic sudden sensorineural hearing loss.Methods Adiponectin Was determined by ELISA method,Hs-CBP was determined by rate nephelometry immunoassuy.The levels adiponectin and Hs-CRP were determined in the 102 idiopathic sudden sensorineural hearing loss patients who were observed at two different time points:before and after treatment,and thirty-five patients with other neurologic diseases(20with sciatica,16withtrigeminal neuralgia)and thirty healthy people were used as control.Results The levels of Hs-CRP in serum of patients with idiopathic sudden sensorineural hearing loss were markedly higher than those in the two control groups(P<0.01);the levels of Hs-CRP in the idiopathic sudden sensorineural hearing loss group after treatment were significantly less than that before treatment(P<0.01).The levels adiponectin in serum of pailents with idiopathic sudden sensorineural hearing loss were markedly lower than those in the two control groups(P<0.01);the levels of adiponectin in the idiopathic sudden sensorineural hearing loss group after treatment were significantly higher than that before treatment(P<0.01).There was negatively correlation between adiponectin and Hs-CRP in patients with idiopathic sudden sensorineural hearing loss(r=-0.63,P<0.01).Conclusion The levels of serum adiponectin and Hs-CRP have instructive significance in idiopathic sudden sensorineural hearing loss treating and prognosis estimating.%目的 探讨突发性耳聋患者血清脂联素和血清高敏C-反应蛋白(Hs-CRP)的含量变化,及其在突发性耳聋发生过程中的作用和意义.方法 采用酶联免疫(ELISA)法检测血清脂联素含量,采用免疫比浊法对血清Hs-CRP进行测定;检测102例突发性耳聋患者、35

  10. Analysis of prognostic factors for sudden sensorineural hearing loss with the treatment of medication%突发性耳聋的预后相关因素分析

    Institute of Scientific and Technical Information of China (English)

    陈菲菲; 胡海文; 李靖; 李文波

    2016-01-01

    Objective To study the efficacy and prognostic factors for sudden sensorineural hearing loss with the treat-ment of mouse nerve growth factor and other medication. Methods 134 sudden sensorineural hearing loss ears were reviewed retrospectively in our department. They were treated by mouse nerve growth factor, lipo-prostaglandin E1, ginaton and methyl-prednisolone, the therapeutic effect were evaluated by pure tone audiometry. Results The total effective rate was 82.1%. Age, the time of diagnosis and therapy, the type of audiogram and degree of hearing loss would be connected with the prognosis (P<0.05 or P<0.01). Conclusion The curative effect of patients whose age is under 50 have short duration and mild degree of deafness is better than those whose age is over 50, have long duration and severe degree of deafness. The types in low tone frequencies show the best curative effect, followed by the types in all frequencies, the types in high tone frequencies and the to-tal deafness have poor curative effect.%目的:研究鼠神经生长因子等药物治疗突发性耳聋的疗效及其预后影响因素。方法回顾性分析我科收住的134耳突发性耳聋患者,给予鼠神经生长因子、前列腺素E1脂微球载体、银杏叶提取物、甲强龙静脉输液治疗,纯音听阈检查判定疗效。结果药物治疗的总有效率为82.1%。年龄、发病至就诊时间、听力曲线类型及听阈损失程度与疾病的预后相关(P<0.05或P<0.01)。结论年龄<50岁、病程短、听力损失程度轻的患者比年龄≥50岁、病程长、听力损失程度重的患者疗效好。低频听力下降型治疗效果最好,全频听力下降型次之,高频听力下降型和全聋治疗效果差。

  11. 伴感音神经性聋的耳鸣患者临床表现及心理声学特点%Clinical and psychoacoustic characteristics of tinnitus patients with sensorineural hearing loss

    Institute of Scientific and Technical Information of China (English)

    陈秀兰; 秦兆冰

    2011-01-01

    OBJECTIVE To investigate the clinical and psychoacoustic characteristics of tinnitus patients with sensorineural hearing loss, the characteristics of tinnitus were identified in order to facilitate their further management.METHODS One hundred and fifty seven tinnitus sufferers were studied. All the patients were interviewed by the same investigator, using the same questionnaire. Data were collected and analyzed. RESULTS There was a slight predominance of males. The hearing impairment results were limited to the high frequencies in 53.50% of the patients, pitchmatching was limited to high frequencies in 70.70% of the patients with sensorineural hearing loss (SNHL), while 94.05%of the patients with high-frequency SNHL had a high-pitched tinnitus. CONCLUSION There is a significant relationship between high-pitched tinnitus and high-frequency SNHL.There is no significant correlation between tinnitus severity and tinnitus loudness.%目的 通过对157例伴感音神经性聋的主观性耳鸣患者分析,了解耳鸣的临床表现和心理声学特点,为耳鸣诊治提供科学依据.方法 采集157例伴感音神经性聋的主观性耳鸣患者的基本信息、既往史、临床表现、听力学及耳鸣检测结果资料,分析耳鸣的临床特点及各因素与耳鸣之间的关系.结果 157例患者男女比为1.6:1,听力下降以高频为主(53.50%),耳鸣大多数是高调蝉鸣样声音,耳鸣匹配的频率与纯音听阈升高最大的频率关系密切.结论 伴感音神经性聋的耳鸣患者中,以高调耳鸣为主,耳鸣匹配声音类型以纯音居多,耳鸣与听力损失最大的音频近似;耳鸣的响度与耳鸣的严重程度无相关性.

  12. Intratympanic dexamethasone injection in treating refractory sudden sensorineural hearing loss%鼓室内注射地塞米松治疗难治性突发性聋

    Institute of Scientific and Technical Information of China (English)

    姚建慧; 陈庆峰; 施乐娟; 陈向平

    2016-01-01

    Objective To analyze the effect of intratympanic dexamethasone injection(ITDI) in sudden sensorineural hearing loss with diabetes and hypertension (refractory sudden sensorineural hearing loss, RSSNHL). Methods There were 35 patients (35 ears) in the treatment group, including 13 cases of hypertension, 15 cases of diabetes and 7 cases of hypertension with diabetes. They received intratympanic dexamethasone injection (5mg/d, qod ×5 times). The 71 patients (71 ears) of the control group received intravenous dexamethasone injection (10mg/d, qd ×7ds, then 5mg/d, qd ×7ds). Results Hearing improvement was observed in 27 (77.14%) in the treatment group and 57 (80.28%) in the control group, and without significant difference between the two groups (χ2=0.14, P>0.05). The tinnitus disappearance rate was observed 78.57% in the treatment group and 71.15% in the control group, and also without significant difference(χ2=0.52, P>0.05). Vertigo had disappeared in all cases. Conclusions Intratympanic dexamethasone injection could have the identical effectiveness for refractory sudden sensorineural hearing loss in case of impossible use of general steroid treatment.%目的:探讨鼓室内注射地塞米松治疗伴有糖尿病、高血压的突发性耳聋(难治性突发性耳聋)患者的疗效。方法观察组35例(35耳),高血压13例,糖尿病15例,7例高血压加糖尿病。鼓室内注射地塞米松溶液5mg,隔日注射一次,共注射5次。对照组71例(71耳),静脉注射地塞米松10mg,连续7天,后减为5mg治疗7天。结果观察组:35例,有效率为77.14%(27/35)。对照组:有效率为80.28%(57/71)。两组比较χ2=0.14,P>0.05,差异无统计学意义;观察组耳鸣消失率为78.57%(22/28);对照组耳鸣消失率为71.15%(37/52)。两组比较χ2=0.52,P>0.05,差异无统计学意义;两组患者眩晕均全部消失。结论在不能全身使用激素的情况下,采用鼓室

  13. 鼓室内注入类固醇激素补救治疗突发性聋的文献Meta分析%Intratympanic Steroid in Idiopathic Sudden Sensorineural Hearing Loss as Salvage Treatment: A Meta-analysis

    Institute of Scientific and Technical Information of China (English)

    黄冠; 华清泉

    2011-01-01

    目的 评价鼓室内注入类固醇激素补救治疗突发性聋的疗效及安全性.方法 通过对Cochrane图书馆、PubMed、EMbase、CBM、万方全文数据库进行计算机检索以及手工检索,对所纳入的所有应用鼓室内注入类固醇激素补救治疗突发性聋文献的随机对照试验结果(randomized controlled trials,RCTs)进行Meta分析.结果 共检索到9篇文献,425例患者(426耳)符合纳入标准.Meta分析结果显示,鼓室内注入类固醇激素补救治疗突发性聋的有效率均高于对照组[RR(95%CI)分别为10.86(4.06,29.4)、7.32(1.37,39.28)、2.10(1.00,4.37)、8.13(1.20,55.61)].有5篇文献共报道了7例该疗法的并发症,主要为注射后短暂眩晕(4例)、耳部烧灼感(1例)、耳垂部丘疹(1例)、中耳炎(1例).结论 虽然鼓室内注入类固醇激素补救治疗突发性聋的有效率有高于其他治疗方法的趋势,但由于纳入的随机对照试验质量普遍较低,因此,该疗法的疗效及安全性还需更多高质量的大样本、多中心的随机对照试验来进一步证实.%Objective To assess the effectiveness and safety of intratympanic steroid in idiopathic sudden sensorineural hearing loss as salvage treatment.Methods A thorough literature search was performed among electronic databases and by hand searching,and then evaluate the randomized controlled triats(RCTs) of intratympanic steroid in idiopathic sudden sensorineural hearing loss as salvage treatment.Results We found 9 RCTs involving 425 patients(426 ears).Meta-analysis showed a better effect of intratympanic steroid in idiopathic sudden sensorineural hearing loss as salvage treatment than the control group[RR(95%CI)were 10.86(4.06,29.4),7.32( 1.37,39.28),2.10( 1.00,4.37), 8.13 ( 1.20,55.61 )].Five literatures reported the side effects of intratympanic steroid, most of which were temporary vertigo, buring discomfort and papules on the earlobe, the incidence of secondary infection and increasing

  14. 鼓室内联合全身应用糖皮质激素治疗全聋型突发性聋%Combined systemic and intratympanic usage of steroids in sudden total sensorineural hearing loss

    Institute of Scientific and Technical Information of China (English)

    屈永涛; 张慧平; 陈红耀; 郭明丽

    2016-01-01

    目的:探讨早期鼓室内联合全身应用糖皮质激素治疗全聋型突发性聋的疗效情况。方法选取我院自2011年3月至2015年3月间收治的130例全聋型突发性聋患者,按照治疗方案分不同为治疗组与对照组,对照组给予糖皮质激素全身给药、营养神经及改善微循环类药物治疗,而治疗组在对照组用药基础之上加用糖皮质激素鼓室内注射治疗,观察和分析各组疗效情况。结果糖皮质激素联合治疗组听力改善的总有效率达到88.7%,而糖皮质激素全身治疗组听力改善的总有效率为70.6%,治疗组与对照组差异比较有统计学意义(P<0.05)。糖皮质激素联合治疗组耳鸣改善的总有效率达到82.5%,而糖皮质激素全身治疗组耳鸣改善的总有效率为77.2%,但是两组之间的差异没有统计学意义(P>0.05)。两组患者眩晕改善的总有效率均为100%。结论鼓室内联合全身应用糖皮质激素治疗全聋型突发性聋能够取得较好的疗效。%Objective To report outcomes of combined systemic and intratympanic usage of steroids in treating sud-den total sensorineural hearing loss. Methods From March 2011 to March 2015, 130 patients diagnosed with sudden total sensorineural hearing loss were divided into a control group to be treated with systemic steroid, neurotrophic agents and microcirculation improving drugs, and a study group to receive intratympanic steroids injection in addition to the control group treatment. Treatment outcomes were analyzed. Results The total effectiveness rate regarding hearing was 88.7%in the study intratympanic group and 70.6% in the control group (P0.05). The total effectiveness rate on dizziness was 100%in both groups. Conclusions Combined systemic and intratympanic usage of steroids can achieve a more favorable outcome in the treat-ment of sudden total sensorineural hearing loss.

  15. 老年感音神经性听力障碍患者助听器验配效果分析%The Causal Effects of Different Factors on the Amplification Outcomes in the Elderly Patients with Sensorineural Hearing Loss

    Institute of Scientific and Technical Information of China (English)

    张建一; 张五玲; 西品香; 马佳; 孔立时

    2013-01-01

      在我国,感音神经性听力障碍患者对助听器的认知度和接受度较低,已验配助听器的患者助听器常戴率不高,助听器使用者对助听器综合效果的满意率也不高。老年感音神经性听力障碍患者助听器效果差异化非常明显。本文重点讨论如何依据听力障碍的类型、听力曲线特征以及临床表现,为不同类型的老年感音神经性听力障碍患者进行个性化的助听器验配,力求使助听器效果最大化。%In China, only a small part of patients with sensorineural hearing loss use hearing aids and a small proportion of hearing aid users wear hearing aids regularly. Many hearing aid users are not satisfied with the outcomes of hearing aids. The effects of hearing aids can be significantly different among patients. This article discusses how to fit hearing aids for the elderly patients with sensorineural hearing loss according to the types of hearing impairment, characteristics of audiogram and clinical symptoms of each patient so as to optimize the outcomes of hearing aids.

  16. 糖皮质激素鼓室内灌注治疗突发性耳聋的研究进展%Research Progress of Intratympanic Glucocorticoids Treating Sudden Sensorineural Hearing Loss

    Institute of Scientific and Technical Information of China (English)

    刘冬梅

    2012-01-01

    Sudden sensorineural hearing losss( SSHL )is a common emergency of E. N. T. department. Its onset is urgent,the hearing loss degree and complications can aggravate with the course. The incidence of SSHL has been in an uptrend, and hearing loss, tinnitus and dizziness seriously affect people's normal life and work. Cause of the disease is not completely clear,which may occur as many other disease's complications, making the treatment more difficult. Though there are plenty of existing treatments in clinic, much of the effect is not ideal, since most of them are etilogical treatment or empirical treatment. Currently intratympanic perfusion therapy with gluccorticocoids is reported more and more and has been used as the measure for refractory deafness all the time,which is expected to be an effective solution to the above mentioned problems.%突发性耳聋是耳鼻喉科常见疾病,起病急,听力下降程度和并发症可随病程增加而加重.发病率呈上升趋势,听力下降及耳鸣、眩晕等严重影响了人们的正常生活和工作.本病病因不全明确,可作为很多疾病的并发症出现,治疗难度大.如今临床上治疗方法众多,主要为病因治疗或经验性治疗,但大多临床疗效不理想.目前糖皮质激素鼓室内灌注治疗方法报道增多,并一直被作为突发性耳聋的挽救性治疗方法,有待成为解决上述问题的有效方法.

  17. 突发性聋伴良性阵发性位置性眩晕的预后分析%Prognosis of Idiopathic Sudden Sensorineural Hearing Loss with Benign Paroxysmal Positional Vertigo

    Institute of Scientific and Technical Information of China (English)

    龚桃根; 郑铨艺; 柯朝阳; 曾凡倩; 廖志芳

    2016-01-01

    目的:探讨突发性聋伴良性阵发性位置性眩晕(benign paroxysmal positional vertigo,BPPV)患者的预后。方法回顾性分析105例突发性聋患者的临床资料,根据有无伴眩晕以及体位试验的结果分为三组:突发性聋伴BPPV组(13例)、突发性聋伴非BPPV眩晕组(27例)、突发性聋不伴眩晕组(65例),比较三组患者治疗前后的听力情况。结果突发性聋伴BPPV组与突发性聋伴非BPPV眩晕组听力损失较突发性聋不伴眩晕组重,且预后相对较差。结论BPPV是突发性聋的不良预后因素,耳石手法复位对BPPV治疗有效。%Objective To report treatment outcomes of idiopathic sudden sensorineural hearing loss (ISSNHL) with be-nign paroxysmal positional vertigo (BPPV). Methods Clinical data from 105 patients with ISSNHL were reviewed retro-spectively. Patients were divided into 3 groups based on vertigo symptoms and results of positional test, namely, ISSNHL with BPPV (n=13), ISSNHL with non BPPV vertigo (n=27) and ISSNHL without vertigo (n=65),for analysis of rela-tionship between hearing improvement and BPPV. Results Patients with ISSNHL and BPPV or non BPPV vertigo displayed worse hearing loss and had significantly less improvement as compared to those without vertigo. Conclusions BPPV is a poor prognostic factor in ISSNHL, but successful otolith repositioning can be achieved by proper canalith repositioning tech-niques.

  18. Determination of serum resistin and high-sensitivity C-reactive protein in patients with idiopathic sudden sensorineural hearing loss and their clinical significance%抵抗素和高敏C-反应蛋白在突发性耳聋中的临床意义

    Institute of Scientific and Technical Information of China (English)

    牛善利; 马惠平; 张冬梅; 黄友敏

    2008-01-01

    目的 探讨突发性耳聋患者血清抵抗素和高敏C-反应蛋白(hs-CRP)的含量变化,及其在突发性耳聋发生过程中的作用和意义.方法 检测102例突发性耳聋组、35例其他疾病对照组和30例健康对照组的血清抵抗素和hs-CRP含量,并比较治疗前后血清抵抗素和hs-CRP含量的变化.结果 突发性耳聋组患者治疗前血清抵抗素和hs-CRP含量较其他疾病对照组和健康对照组显著升高(P<0.01);治疗后突发性耳聋组患者抵抗素和hs-CRP含量明显降低.突发性耳聋患者血清抵抗素和hs-CRP含量呈正相关(r=0.65,P<0.01).结论 血清抵抗素和hs-CRP含量的变化与突发性耳聋病情严重程度密切相关.%Objective To study the role of serum resistin and high-sensitivity C-reactive protein (hs-CRP) in idiopathic sudden sensorineural hearing loss. Methods The levels resistin and hs-CRP were determined in the 102 idiopathic sudden sensorineural hearing loss patients who were observed at two differ-ent time points: before and after treatment, and 35 patients with other neurologic diseases and 30 healthy people were used as control. Results The levels resistin and hs-CRP in serum of patients with idiopathic sudden sensorineural hearing loss were markedly higher than those in the controls (P< 0.01). The levels of resistin and ha-CRP in the patients with idiopathic sudden sensorineural hearing loss after treatment were significantly less than those before treatment. There was a correlation between serum resistin and hs-CRP in patients with idiopathic sudden senserineural hearing loss (r=0.65, P<0.01). Conclusion The levels of serum resistin and hs-CRP have instructive significance in idiopathic sudden sensorineural hearing loss treating and prognosis estimating.

  19. 内耳出血所致突发性聋患者临床表现特点分析%Clinical features of sudden sensorineural hearing loss accompanied with inner ear hemorrhage

    Institute of Scientific and Technical Information of China (English)

    陈希杭; 林昶; 方哲明; 陈曦; 叶胜难; 程金妹; 张榕

    2015-01-01

    Objective To investigate the clinical features, diagnosis and prognosis of sudden sensorineural hearing loss accompanied with inner ear hemorrhage.Methods Eleven cases of sudden sensorineural hearing loss accompanied with inner ear hemorrhage were retrospectively analyzed, including clinical manifestation, hematological and audiological examinations, as well as characteristics of inner ear three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging (3D-FLAIR MRI).Results Eleven cases of sudden hearing loss with inner ear hemorrhage were accompanied by varying degrees of vertigo, lasting from several minutes to several hours, nine of whom had persistent tinnitus.The audiometry curves of the 11 cases included total deafness or flat descending type.The inner ear 3D-FLAIR MRI studies revealed abnormal high signals at different positions of the inner ear, one case with endolymphatic hydrops.After the treatment, seven cases were invalid, two cases had notable effect, and two cases were effective.Conclusions Abnormal high signals in the inner ear were sensitively detected by 3D-FLAIR MRI sequence, which was applied for the diagnosis of the sudden hearing loss accompanied with inner ear hemorrhage.The effect of conventional treatment was not good and the appropriate treatments for this type of sudden hearing loss need further investigation.%目的 探讨内耳出血所致突发性聋患者的临床特点、诊断方法及预后情况.方法 回顾性分析2010年1月至2014年10月11例考虑为内耳出血所致突发性聋患者的临床资料,包括临床表现、实验室检查、听力学、内耳MRI影像学特征等.结果 11例患者中男5例、女6例,年龄23~73岁(中位年龄44岁);均伴有不同程度的眩晕,持续数分钟至数小时不等,其中9例患者伴有持续性耳鸣;根据听力曲线分型,全聋型9例,平坦下降型2例.11例患者通过三维液体衰减反转恢复(three-dimensional fluid

  20. Intratympanic steroids to treat refractory sudden sensorineural hearing loss (52 cases report)%鼓室内注射治疗难治性突发性耳聋52例

    Institute of Scientific and Technical Information of China (English)

    严小玲; 毛敏; 翟锦明; 陈观贵; 张建国; 刘绮明; 薛进平

    2014-01-01

    Objective To investigate the effect of intratympanic steroids as a salvage method to treat the patients with refractory sudden sensorineural hearing loss who did not respond to initial primary systemic steroid therapy.Methods Reviews were performed for 96 patients hospitalized between 2010 and 2013.Among them,52 patients accepted intra-tympanic steroids injection,and the remaining 44 patients who refused intratympanic treatment were served as the con-trol group.Mean air conduction at four frequencies (0.5,1,2,and 4 kHz)were monitored.Hearing results was com-pared before and 1 month after the treatment.Results Hearing improvement was defined as more than 10 dB in pure tone average(PTA).The hearing improvement was 30.8%(16 cases)in the intratympanic group but 6.8%(3 cases) in the control (P<0.01).Conclusion Intratympanic steroid injection is an effective therapy for sudden sensorineural hearing loss patients who are refractory to primary systemic steroid therapy.%目的:探讨鼓室内注射激素作为难治性突发性耳聋的补救治疗措施的临床疗效。方法重度及极重度突发性耳聋患者96例,接受常规治疗加全身应用激素2周效果不佳,其中52例接受鼓室注射激素,另外44例拒绝鼓室内注射而继续口服药物治疗。纯音测听法(PTA)检测患者补救治疗前后听力,比较气导听阈(0.5、1.0、2.0、4.0 kHz四个频率气导之平均值),分析两组患者补救治疗前后听力结果。结果鼓室注射组听力提高10 dB以上的患者16例,有效率为30.8%;而对照组仅有3例,有效率为6.8%。两组听力改善值之间的差异有统计学意义(P<0.01)。结论鼓室内激素注射对突发性耳聋常规治疗无效的患者有良好的疗效,可以作为一种补救治疗措施。

  1. Association of ICAM-1 gene polymorphism with sudden sensorineural hearing loss%细胞粘附分子-1469K/E基因多态性与突发性聋的相关性研究

    Institute of Scientific and Technical Information of China (English)

    张芳; 田广永; 段永畅; 杨静雅; 唐玲

    2015-01-01

    Objective To determine the relationship between the 469K/E polymorphism (rs5498) of the ICAM-1 gene and sudden sensorineural hearing loss. Methods Subjects used in this study were derived from the Third Affiliated Hospital of Southern Medical University. Two milliliters of venous blood were obtained from each participant for genomic DNA extraction. Detection of SNPs rs5498 was performed by polymerase chain reaction (PCR), followed by restriction fragment length polymorphism (RFLP) analysis. The restriction enzyme-digested PCR products were analyzed by 2% agarose gel electrophoresis. The Chi-square test was used to compare the frequency of alleles and genotypes between case and control groups. Results Seven-ty-five SSNHL patients (39 male and 36 female patients) were compared with 165 controls (86 male and 79 female subjects) enrolled in this study from June 2014 to July 2015. No significant differences in ICAM-1 469K/E genotype and allele frequencies were found between the SSNHL group and controls. However, there were significant differences in ICAM-1 469K/E polymorphism between patients with different types of hear-ing loss. Conclusion Our study results do not show significant association between 469K/E polymorphism of the ICAM-1 gene and sudden sensorineural hearing loss. The E allele may influence the susceptibility to the development of flat type of hearing loss.%目的:探讨细胞粘附分子-1(ICAM-1)469K/E基因多态性是否与突发性聋存在相关性。方法按照入选标准共选取了240例研究对象,包括突发性聋患者75例(男39例,女36例),对照者165例(男86,女79例),分别抽取2ml外周静脉血,提取DNA,PCR扩增目的片段,扩增产物经限制性酶切后行琼脂凝胶电泳,以此确定所有研究对象ICAM-1469K/E的基因分型。通过统计分析明确ICAM-1469K/E与突发性聋是否相关。结果两组之间ICAM-1469K/E基因分型及等位基因分布频率差异无统计学意义,

  2. Mitochondrial 12S Ribosomal RNA A1555G Mutation Associated with Cardiomyopathy and Hearing Loss following High-Dose Chemotherapy and Repeated Aminoglycoside Exposure

    DEFF Research Database (Denmark)

    Skou, Anne-Sofie; Tranebjærg, Lisbeth; Jensen, Tim;

    2014-01-01

    A 19-month-old girl with the A1555G mitochondrial mutation in the 12S ribosomal RNA gene and acute myelogenous leukemia developed dilated cardiomyopathy and bilateral sensorineural hearing loss before undergoing allogeneic stem cell transplantation. She had received gentamicin during episodes of ...

  3. 突发性耳聋患者HMGBl和ENA-78含量在治疗前后变化的意义%Determination of serum HMGB1 and ENA-78 in patients with idiopathic sudden sensorineural hearing loss and its clinical significance

    Institute of Scientific and Technical Information of China (English)

    牛善利; 黄友敏; 周永勤; 华敏

    2011-01-01

    Objective To study the role and clinical significance of serum high mobility group box -1 ( HMGB1) and epithelial neutrophil-activing peptide-78( ENA-78) in idiopathic sudden sensorineural hearing loss by measuring the change of their levels in the patients with idiopathic sudden sensorineural hearing loss . Methods The levels HMGB1 and ENA-78 were determined by ELISA method in the 102 idiopathic sudden sensorineural hearing loss patients who were observed at two different time points : before and after treatment,and thirty-five patients with other neurologic diseases ( 20 with sciatica,16 with trigeminal neuralgia ) and thirty healthy people were used as control. Results The levels HMGB1 and ENA-78 in serum of patients with idiopathic sudden sensorineural hearing loss were markedly higher than those in the two control groups (P < 0. 01 ) ; The levels of HMGB1 and ENA-78 in the idiopathic sudden sensorineural hearing loss group after treatment were significantly less than that before treatment (P <0. 01 ). There was a correlation between HMGB1 and ENA-78 in patients with idiopathic sudden sensorineural hearing loss (r =0. 68, P < 0. 01 )Conclusions The levels of serum HMGB1 and ENA-78 have instructive significance in idiopathic sudden sensorineural hearing loss treating and prognosis estimating .%目的 探讨突发性耳聋患者血清高迁移率蛋白-1(HMGB1)和中性粒细胞激活肽-78(ENA-78)的含量变化,及其在突发性耳聋发生过程中的作用和意义.方法 采用酶联免疫(ELISA)法检测血清HMGB1和ENA-78含量;检测102例突发性耳聋患者、35例其他疾病对照组和30例健康对照组的血清HMGB1和ENA-78含量,并比较治疗前后血清HMGB1和ENA-78的测定结果 .结果 突发性耳聋患者治疗前血清HMGB1和ENA-78含量较两对照组显著升高(P<0.01);治疗后患者HMGB1和ENA-78含量明显降低.同时重度组突发性耳聋患者血清HMGB1和ENA-78浓度明显高于中、轻度

  4. 突发性耳聋患者血清内脂素和ENA-78含量变化的意义%Clinical significance of the levels of serum visfatin and ENA-78 in patients with idiopathic sudden sensorineural hearing loss

    Institute of Scientific and Technical Information of China (English)

    武静; 黄友敏; 周永勤

    2012-01-01

    目的 探讨突发性耳聋患者血清内脂素(visfatin)和中性粒细胞激活肽-78( ENA-78)的含量变化,及其在突发性耳聋发生过程中的作用和意义.方法 采用酶联免疫吸附试验检测血清内脂素和ENA-78含量;检测102例突发性耳聋患者,35例其他疾病对照组和30例正常健康对照组的血清内脂素和ENA-78含量,比较治疗前后血清内脂素和ENA-78的测定结果.结果 突发性耳聋患者治疗前血清内脂素和ENA-78含量较两对照组显著升高(P<0.01);治疗后恢复组患者内脂素和ENA-78含量明显降低.同时突发性耳聋重度组患者血清内脂素和ENA-78浓度明显高于中、轻度组,中度组患者明显高于轻度组,且差异有统计学意义(P<0.01).突发性耳聋患者血清内脂素和ENA-78含量之间呈正相关(r=0.68,P<0.01).结论 血清内脂素和ENA-78水平的变化与突发性耳聋病情严重程度密切相关.%Objective To study the role and clinical significance of serum visfatin and epithelial neutrophil-activing peptide-78 ( ENA-78 ) in idiopathic sudden sensorineural hearing loss by measuring the changes in the patients with idiopathic sudden sensorineural hearing loss.Methods The levels of visfatin and ENA-78 were determined by ELISA method in 102 idiopathic sudden sensorineural hearing loss patients who were observed at two different time points:before and after treatment,and thirty-five patients with other neurologic diseases (20 with sciatica,16 with trigeminal neuralgia) and thirty healthy people were enrolled in control group.Results The levels of serum visfatin and ENA-78 in patients with idiopathic sudden sensorineural hearing loss were markedly higher than those of the other two control groups (P < 0.01 ) ; The levels of serum visfatin and ENA-78 in the idiopathic sudden sensorineural hearing loss group after treatment were significantly lower than those before treatment ( P < 0.01 ).The levels of serum visfatin and ENA-78

  5. Therapeutic effect of intratympanic dexamethasone injections on sudden sensorineural hearing loss:a report of 35 cases%地塞米松鼓室内灌注治疗突发性聋35例疗效观察

    Institute of Scientific and Technical Information of China (English)

    李河清; 孟祥明; 文庆波

    2009-01-01

    突发性聋(sudden sensorineural hearing loss,SSNHL)是指突然发生的、原因不明的感音神经性听力损失,患者的听力一般在数分钟或数小时内至最低点,少数患者在3d以内;可伴有耳鸣及眩晕;除第Ⅷ颅神经症状外,无其他颅神经症状。由于病因不明、机制不清,目前临床上多采用综合疗法,Silverstein在1996年首次应用鼓室灌注类固醇激素治疗突发性聋,之后关于鼓室灌注类固醇的基础、临床和药代动力学研究成为耳科学研究的热点。鼓室给药的方法除了鼓膜穿刺外,还有圆窗龛放置明胶海棉、微量灌注泵、鼓膜置管术及经咽鼓管给药等途径。我们采用鼓膜穿刺地塞米松鼓室内灌注治疗突发性聋,取得一定疗效,现报告如下。

  6. The progress of IGF-1 in preventing and curing sensorineural hearing loss and its mechanism%IGF-1防治感音神经性耳聋及机制的研究进展

    Institute of Scientific and Technical Information of China (English)

    涂厚义; 陈茜; 殷泽登

    2014-01-01

    Sensorineural hearing loss is a common disease and apoptosis of cochlear cells is one of the most common causes. Insulin like growth factor-1(IGF-1) activates cell cycle and inhibits apoptosis by diverse signal transduction pathways,plays an important role in the regulation of cochlear growth, development and differentiation,and maintaining cochlear survival and recovery under cochlear cell damage. There were some progresses in the treatments of sudden deafness and drug deafness by local application of IGF-1.%感音神经性耳聋是耳鼻咽喉科常见病,耳蜗细胞凋亡是感音神经性耳聋的主要原因之一。IGF-1通过多种信号转导途径激活细胞周期和抑制细胞凋亡,从而参与耳蜗细胞正常的生长、发育和分化,以及在耳蜗细胞损伤时参与维持细胞的存活和修复。IGF-1局部应用对于治疗突发性聋、药物性聋等感音神经性聋方面的研究取得了进展。

  7. PECONPI: a novel software for uncovering pathogenic copy number variations in non-syndromic sensorineural hearing loss and other genetically heterogeneous disorders.

    Science.gov (United States)

    Tsai, Ellen A; Berman, Micah A; Conlin, Laura K; Rehm, Heidi L; Francey, Lauren J; Deardorff, Matthew A; Holst, Jenelle; Kaur, Maninder; Gallant, Emily; Clark, Dinah M; Glessner, Joseph T; Jensen, Shane T; Grant, Struan F A; Gruber, Peter J; Hakonarson, Hakon; Spinner, Nancy B; Krantz, Ian D

    2013-09-01

    This report describes an algorithm developed to predict the pathogenicity of copy number variants (CNVs) in large sample cohorts. CNVs (genomic deletions and duplications) are found in healthy individuals and in individuals with genetic diagnoses, and differentiation of these two classes of CNVs can be challenging and usually requires extensive manual curation. We have developed PECONPI, an algorithm to assess the pathogenicity of CNVs based on gene content and CNV frequency. This software was applied to a large cohort of patients with genetically heterogeneous non-syndromic hearing loss to score and rank each CNV based on its relative pathogenicity. Of 636 individuals tested, we identified the likely underlying etiology of the hearing loss in 14 (2%) of the patients (1 with a homozygous deletion, 7 with a deletion of a known hearing loss gene and a point mutation on the trans allele and 6 with a deletion larger than 1 Mb). We also identified two probands with smaller deletions encompassing genes that may be functionally related to their hearing loss. The ability of PECONPI to determine the pathogenicity of CNVs was tested on a second genetically heterogeneous cohort with congenital heart defects (CHDs). It successfully identified a likely etiology in 6 of 355 individuals (2%). We believe this tool is useful for researchers with large genetically heterogeneous cohorts to help identify known pathogenic causes and novel disease genes.

  8. The Effectiveness of Hearing Aids in the Treatment for Tinnitus Patients with Sensorineural Hearing Loss%配戴助听器治疗伴有感音神经性听力减退的耳鸣患者的临床初探

    Institute of Scientific and Technical Information of China (English)

    徐万红; 向阳红; 邓安春; 刘庆顺

    2013-01-01

      目的探讨配戴助听器治疗伴有感音神经性听力减退的耳鸣患者的临床疗效.方法根据入组时的听力图类型将56名伴有感音神经性听力减退的耳鸣患者分为平坦型、上升型、下降型和切迹型4组,采用耳鸣残疾评估量表评估其配戴助听器前后耳鸣的变化程度,了解配戴助听器治疗伴有感音神经性听力减退的耳鸣患者的疗效.结果配戴助听器半年后,耳鸣情况得到改善,无论从THI总体得分,还是分别从功能性、情感性、严重性三个方面的评分来看,配戴助听器后均有明显改善(P0.05).结论配戴助听器对部分伴有感音神经性听力减退的耳鸣患者有效.%Objective To study the efficacy of the application of hearing aids to the treatment of tinnitus patients with sensorineural hearing loss. Methods The tinnitus patients were divided into 4 groups according to the audiometric curve types: flat, ascending, descending and notched. The Tinnitus Handicap Inventory (THI) was used to assess the tinnitus degrees of the patients. Results Half a year after wearing hearing aids, the tinnitus of the patients was significantly reduced according to the total THI scores or functional, emotional and catastrophic scores(P0.05). Conclusion Appropriate hearing aids are effective in the treatment for some tinnitus patients with sensorineural hearing loss.

  9. Different prognostic characteristics between profound sudden sensorineural hearing loss and total sudden hearing loss%突发性极重度聋与全聋的预后特点及差异

    Institute of Scientific and Technical Information of China (English)

    赵晖; 傅窈窈; 张天宇; 迟放鲁; 景江华

    2010-01-01

    Objective To clarify the different prognostic characteristics between profound sudden sensorineural hearing loss (SSNHL) and total SSNHL. Methods The patients with SSNHL who visited Eye Ear Nose and Throat Hospital from June 2007 to September 2008 were reviewed retrospectively. All the 204 patients, with pure tone average (PTA) threshold more than 90 dB, were enrolled and divided into two groups, including total SSNHL and profound SSNHL groups. The relationship between recovery rate and prognostic factors including the age, complications, time period between onset and therapy was analyzed.Results There were 57 cases of total SSNHL and 147 cases of profound SSNHL in this series. Tinnitus was complained in more than 90% of the patients in both groups, which was higher than that of dizziness and ear fullness. Dizziness was present in 64. 9% (37/57) patient with total SSNHL group and 45.6% (67/147)patients with profound SSNHL, which had significant difference between the two groups (x2 = 5.72,P =0. 017). The PTA threshold improvement in total SSNHL group and profound SSNHL group was (36. 4 ±19.3) dB and (40. 2 ±21.3) dB respectively, which was no significant difference between the two groups (t = 1. 165 ,P =0. 245). The cured patients were all those received therapy within 1 week following the onset of SSNHL, which was of 2. 6% (1/38) patients in the total SSNHL group and 14. 3% (14/98) patients in the profound SSNHL group(P =0. 045). Furthermore, 3.5% (2/57) patients in total SSNHL group as well as 29. 9% (44/147) patients in profound SSNHL group obtained a good result with PTA threshold ≤50 dB after therapy(x2 = 15.92,P = 0. 001 ). In addition, the favorable prognosis was related with the onsettherapy time point( P = 0. 001 ), but not related to the patients' age. Conclusion Profound SSNHL and total SSNHL though both with PTA threshold > 90 dB had significant differences recovery rate and need to be studied separately.%目的 研究突发性极重度聋和全聋

  10. 双侧突发性耳聋的临床特征与治疗(附8例分析)%Clinical Characteristics and Treatment of Bilateral Sudden Sensorineural Hearing Loss:A Report of 8 Cases

    Institute of Scientific and Technical Information of China (English)

    赖闻; 钟时勋; 钱怡; 胡国华; 洪苏玲; 康厚墉; 沈暘; 王玲; 胥正艳

    2014-01-01

    Objective To report characteristics and treatment outcomes in patients with bilateral sudden sensorineural hearing loss (BSSHL). Methods From Jan 2012 to June 2013, 318 patients with sudden sensorineural hearing loss were treat⁃ed by the authors. Of these, 8 (2.5%) had BSSHL. We reviewed the charts of these 8 patients, focusing on clinical manifesta⁃tions, audiologic characteristics, radiography, laboratory results and treatment outcomes. Results Seven of the 8 patients re⁃ported simultaneous BSSHL, and the other one had sequential BSSHL. Electrocardiogram, CT and MRI were normal in all pa⁃tients. Abnormal white blood cell count was seen in one case, increased blood viscosities in 5 cases, increased virus antibod⁃ies in 6 cases, abnormal glucose in 1 case, abnormal lipid metabolism profile in 1 case, and increased fibrinogen levels in all 8 cases. After combined multiple therapies tailored to each patient based on subtypes of audiogram, complete hearing recov⁃ery was achieved in 1 ear (6.25%), while the rest showed no responses. Conclusion BSSHL is a complex condition with vari⁃able etiological factors and poor prognosis. It may need to be treated based upon subtypes of audiogram.%目的:分析双侧突发性耳聋的临床特点和治疗方法。方法回顾性分析2012年1月至2013年6月确诊并接受治疗的8例双侧突发性耳聋患者的临床资料,包括临床表现,听力学检查,影像学检查,血液学检查,治疗方法及效果评估等,探讨双侧突发性耳聋的临床特征及治疗方法。结果7例双耳同时发病,1例双耳先后发病。白细胞计数异常1例,血液流变学异常5例,风疹病毒、巨细胞病毒、单纯疱疹病毒IgG抗体异常6例(2例未查),凝血功能均无异常,8例患者纤维蛋白原均升高,血糖增高1例,血脂升高1例。心电图和影像学检查结果均正常。采用分型治疗后,8例患者痊愈1耳,显效0耳,有效0

  11. Behavioral training promotes multiple adaptive processes following acute hearing loss

    OpenAIRE

    Keating, P; Rosenior-Patten, O.; Dahmen, J. C.; Bell, O.; King, A. J.

    2016-01-01

    eLife digest The brain normally compares the timing and intensity of the sounds that reach each ear to work out a sound’s origin. Hearing loss in one ear disrupts these between-ear comparisons, which causes listeners to make errors in this process. With time, however, the brain adapts to this hearing loss and once again learns to localize sounds accurately. Previous research has shown that young ferrets can adapt to hearing loss in one ear in two distinct ways. The ferrets either learn to rem...

  12. Sudden sensorineural hearing loss: a case report supporting the immunologic theory Surdez neurosensorial súbita: relato de um caso clínico corroborando a teoria auto-imune

    Directory of Open Access Journals (Sweden)

    Antonio Luiz dos Santos Werneck

    2003-12-01

    Full Text Available Sudden sensorineural hearing loss (SSNHL is one of the autoimmune diseases of the inner ear (AIED, which is characterized by a hearing loss of above 30 decibels in at least three contiguous audiometric frequencies over a time course of 72 hours or shorter. Its cause can be found in only 10% to 15% of patients. Histopathologic findings have reported retrograde neuronal degeneration and atrophy of Corti's organ and of the vascular stria. This paper describes a case of a middle-aged female patient undergoing a treatment for hyperthyroidism who developed bilateral SSNHL. The patient was treated with methylprednilisone (1mg/kg/day for three days with considerable hearing improvement. This treatment was followed by lung and kidney tuberculosis. The immune mechanism of this entity and the possibility of interconnected participation of the antigen type, of an autoimmune disease and of bacterial infection are discussed.A surdez neurosensorial aguda (SNSA é uma das doenças auto-imunes do ouvido interno caracterizada pela perda da audição acima de 30 decibéis, em pelo menos 3 freqüências audiométricas contíguas, no período máximo de 3 dias. Sua causa só é definida em 10 a 15% dos pacientes. Achados histopatológicos demonstram degeneração neuronal retrógrada e atrofia do órgão de Corti e da estria vascular. Relatamos o caso de uma paciente de média idade em tratamento de hipertireoidismo que apresentou SNSA bilateral. A paciente foi tratada com metil-prednisilona (1mg/kg/dia durante três dias evoluindo para uma melhora considerável da audição. Este tratamento foi seguido de tuberculose pulmonar e renal. Discute-se o mecanismo imunológico desta entidade, e a possibilidade de participação cruzada do tipo antígeno, doença autoimune e infecção bacteriana.

  13. 高压氧辅助治疗感音神经性聋的Meta分析%A Meta-analysis of adjunctive treatment of sensorineural hearing loss with hyperbaric oxygenation

    Institute of Scientific and Technical Information of China (English)

    管红霞; 华清泉; 张志坚; 江洋

    2014-01-01

    目的:评价高压氧辅助治疗感音神经性聋的效果。方法通过计算机检索国内外的数据库,如中国知网、万方、维普、PubMed、EBSCO、Sci Verse Science Direct等,设立纳入和排除标准,筛选符合条件的参考文献,并对文献的质量进行严格的评价和资料的提取,利用Revman 5.2软件对纳入文献的相关指标进行Meta分析。结果共纳入9篇文献,共1184例患者,其中治疗组(高压氧联合常规药物治疗组)465例,对照组(常规药物治疗组)719例。将纳入的患者按两种不同的疗效评价标准进行划分,每中评价标准分别按例数和耳数两个方面进行疗效评价。Meta分析结果显示不同的分析方式,治疗组无论是治愈率还是有效率均高于对照组(P<0.05)。结论高压氧对感音神经性聋具有较好的辅助治疗作用。%Objective To systematically assess the efficacy of sensorineural hearing loss with hyperbaric oxygenation for adjunctive treatment. Methods Search for literature in databases such as Hownet, Wanfang date, VIP, PubMed, EB-SCO, Sci Verse Science Direct, and some standards were set up. At the same time, the references were screened, and the methods were evaluated. Researchers went through strict evaluation and extraction against reference quality, and only the qualified references underwent Meta-analysis with Review Manager 5.2. Results A total of 9 studies with 1184 pooled patients were included, with 465 individuals in experiment group while 719 individuals in control group. There were two parts according to different standards, and analysis cure rate and total effective rate by number of patients and ears. Meta-analysis results implied that the efficacy of experiment group were better than control group in both cure rate and total effective rate in different respects (P<0.05). Conclusion Hyperbaric oxygenation has a great efficacy of sensorineural hearing loss for adjunctive treatment.

  14. Association between sOD2 Polymorphisms and Genetic Susceptibility of Sudden Sensorineural Hearing Loss%SOD2基因多态性与突发性耳聋的遗传易感性研究

    Institute of Scientific and Technical Information of China (English)

    赵跃; 胡律; 邓嘉虹

    2015-01-01

    目的:探讨人线粒体超氧化物歧化酶2(mitochondrial superoxide dismutase 2, SOD2)基因多态性与云南地区突发性耳聋(idiopathic sensorineural hearing loss, SSNHL)患者遗传易感性的关系。方法采用病例-对照研究,选取78例(男35,女43)突发性耳聋患者和与之性别、年龄相匹配的85例(男39,女46)对照群体,对 SOD2基因的3个标签 SNP 位点(rs5746136、 rs2842960、 rs4880)进行基因分型,统计并分析了基因频率和基因型频率分布与突发性耳聋的遗传易感性的关系。结果在 rs5746136位点(OR =2.136,95% CI =1.147~3.978, P =0.016)上的 A/ G 基因型可能是中国突发性耳聋患者的危险基因型,而 rs2842960和 rs4880则和中国突发性耳聋患者无相关性;结论 SOD2基因多态位点 rs5746136 A/ G 基因型可能增加突发性耳聋患者的风险,可以作为预测 SSNHL 患者发病危险及早期防治的的遗传标记。%Objective To investigate the association between mitochondrial superoxide dis-mutase 2 ( SOD2) polymorphisms and genetic susceptibility of sudden sensorineural hearing loss (SSNHL) in patients in Yunnan province of China. Methods Three tag SNPs ( rs5746136, rs2842960, rs4880) variants were genotyped among 78 patients with SSNHL (male: 35, female:43) and 85 age- and sex-matched SSNHL-free control participants (male: 39, female: 46) in this case-control study. The association between gene frequency or gene frequency distribution and genet-ic susceptibility of SSNHL was statistically analyzed. Results rs5746136 (OR = 2. 136, 95% CI =1. 147 – 3. 978, P = 0. 016) A/ G genotype was associated with susceptibility to SSNHL in China, rather than rs2842960 and rs4880. Conclusion Individuals with the SOD2 rs5746136 A/ G geno-type have an increased risk of developing SSNHL, and the SOD2 rs5746136 A/ G genotype may be used as a genetic marker for prediction of the onset risk of SSNHL and early prevention and treat-ment of SSNHL.

  15. Comparing Analog and Digital Hearing Aids in Reducing Hearing Disability

    OpenAIRE

    Ghassem Mohammad Khani; Mohammad Hassan Khalesi; Soghrat Faghih Zadeh; Bahieh Kohansal; Zahra Jafari

    2004-01-01

    Objective: Comparing analog and digital hearing aids reducing disability caused by hearing deficiency among moderate to severe sensorineural hearing-impaired persons. Method and Material: This descriptive-analytic study was carried out on two groups of subjects participated in this study in some audiology clinics of hearing aid since May 2002 to October 2003. Twenty subjects wore analog hearing aids and twenty one subjects wore digital hearing aids. In this study , no subject had previous mid...

  16. Mete analysis of Intratympanic steroids versus oral steroids for sudden sensorineural hearing loss%糖皮质激素经鼓膜与经口途径治疗突发性聋疗效分析

    Institute of Scientific and Technical Information of China (English)

    余啸; 陈波蓓; 项海杰; 高金建; 陈迎迎; 章誉耀; 陈思

    2013-01-01

    目的 通过对现有文献的系统性回顾,比较经鼓膜糖皮质激素疗法(intratympanic steroid,ITS)与经口糖皮质激素疗法在治疗突发性聋(sudden sensorineural hearing loss,SSHL)的差异.数据来源于在线数据库包括Medline、EMBASE和Cochrane Review.方法 纳入符合标准的治疗突发性聋的随机对照试验,对纳入研究的质量进行系统性回顾.结果 作者筛选69篇文献,其中符合标准的文献7篇.在限定两种疗法的剂量、疗程、频次后,Meta分析示ITS组受试者平均纯音听阈(pure tone audiometry,PTA)改善较经口糖皮质激素组高11.13dB (95%可信区间[CI]=9.16-13.11,P<0.00001;Chi2=2.44,df=-2,P=0.30,I2=18%).结论 虽然评估ITS治疗SSHL的高质量研究有限,但其作为第一线治疗组在PTA改善和恢复率上优于受限制的条件下口服类固醇组(口服类固醇给药时间≤10 d,类固醇浓度60 mg/kg·d,和注射的次数是4~5倍之间在ITS).

  17. Analysis of audio-vestibular assessment in acute low-tone hearing loss.

    Science.gov (United States)

    Im, Gi Jung; Kim, Sung Kyun; Choi, June; Song, Jae Jun; Chae, Sung Won; Jung, Hak Hyun

    2016-07-01

    Conclusion This study demonstrated excellent hearing recovery following the combined treatment of diuretic and oral steroid, and electrocochleography (ECoG) was significantly higher than normal side. This study reports characteristics of acute low-tone hearing loss (ALHL) that show the greater low-tone hearing loss, the higher ECoG, and excellent recovery, even-though low-tone hearing loss is worse, which can be different compared with sudden deafness. Objective To analyze ALHL without vertigo, this study compared the ALHL group with all patients exhibiting low-tone hearing loss and ear fullness. Hearing changes and vestibular functions were analyzed. Materials and methods ALHL was defined as a mean hearing loss of ≥ 30 dB at 125, 250, and 500 Hz, and ≤ 20 dB at 2, 4, and 8 kHz. From 156 cases of low-tone hearing loss of more than 10 dB without vertigo, 31 met the ALHL criteria and were subjected to audio-vestibular assessments including PTA, ECoG, vestibular evoked myogenic potential (VEMP) testing, and caloric testing. Results In ALHL, low-tone hearing loss was 42.7 ± 9.5 dB, and 83.9% of ALHL significantly recovered by more than 10 dB. The ECoG in ALHL was 0.334 ± 0.11 (higher than 0.25 ± 0.08 on the normal side) and ECoG abnormality was 35.5% (the greater low-tone hearing loss, the higher ECoG value). PMID:26963446

  18. Number of endothelia progenitor cells from peripheral blood in patients with sudden sensorineural hearing loss%突发性耳聋患者外周血内皮祖细胞的变化

    Institute of Scientific and Technical Information of China (English)

    杨东; 周慧芳

    2012-01-01

    Objective: To investigate the number of endothelia progenitor cells (EPCs) from peripheral blood in patients with sudden sensorineural hearing loss(SSHL) and the proliferative number of EPCs colonies. Methods: Number of EPCs from peripheral blood and number of proliferative colonies of EPCs after 7 d were measured and comparison was made between SSHL group and the healthy group. Results: The number of EPCs reduced significantly in SSHL group compared with contrast group, they were (36.5?.58)/200xl03 cells and(85.3?.55)/200xl03 cells respectively. The number of proliferative colonies of EPCs were(2.01?.31) in SSHL group and (3.80眑.05) in normal group (P?0.01). Conclusion: Because the number of EPCs and the number of proliferative colonies of EPCs significantly lessen in patients with SSHL, EPCs cannot satisfy the body requirement during the process of restoration and result in the symptom of hearing loss.%目的:探讨突发性耳聋患者外周血中内皮祖细胞(EPCs)数量变化及增殖集落变化情况.方法:测定突发性耳聋患者和听力正常健康人外周血中EPCs数量及培养7d后增殖集落数量.结果:突发性耳聋组外周血中EPCs计数为(36.5±2.58)个/20万单个核细胞,听力正常健康人EPCs计数为(85.3±6.55)个/20万单个核细胞,EPCs增殖集落计数分别为(2.01±0.31)个和(3.80±1.05)个,两者比较差异具有统计学意义(P<0.01).结论:突发性耳聋患者由于EPCs数量及增殖集落数量下降,在机体修复过程中不能满足要求而引起耳聋等临床症状.

  19. Rastreamento da mutação mitocondrial A1555G em pacientes com deficiência auditiva sensorioneural Screening of the mitochondrial A1555G mutation in patients with sensorineural hearing loss

    Directory of Open Access Journals (Sweden)

    Luciano Pereira Maniglia

    2008-10-01

    Full Text Available A mutação mitocondrial A1555G é a principal alteração associada à surdez ocasionada pelo uso de aminoglicosídeos. OBJETIVO: Investigar a prevalência da mutação A1555G em pacientes com deficiência auditiva sensorioneural com e sem uso de antibióticos aminoglicosídeos. MATERIAL E MÉTODO: Estudo em amostras de 27 pacientes com surdez, como casos, e em 100 neonatos, com audição normal, como grupo controle. O DNA foi extraído de leucócitos de amostras de sangue e "primers" específicos foram utilizados para amplificar o gene do citocromo b e a região que abrange a mutação A1555G do DNA mitocondrial, usando as técnicas da Reação em Cadeia da Polimerase e do Polimorfismo no Comprimento de Fragmentos de Restrição. DESENHO CIENTÍFICO: Estudo de casos em corte transversal. RESULTADOS: A região do gene do citocromo b foi amplificada, sendo confirmada a presença do DNA mitocondrial em todas as 127 amostras do estudo. A mutação A1555G não foi identificada nos 27 pacientes com deficiência auditiva e no grupo controle (100 neonatos. CONCLUSÕES: Os resultados são concordantes com estudos que relatam que a mutação A1555G não é prevalente nas Américas. Há interesse na determinação da real prevalência dessa mutação e na investigação de outras mutações que possam ocasionar deficiência auditiva associada ou não ao uso de aminoglicosídeos na população brasileira.The A1555G mitochondrial mutation is the main alteration associated with aminoglycoside-induced deafness. AIM: to investigate the prevalence of the A1555G mutation in patients sensorineural hearing loss patients with and without aminoglycosides antibiotic use. MATERIAL AND METHOD: a study of 27 cases with deafness as the sample, and 100 neonates with normal hearing as the control group. DNA was extracted from blood leukocyte samples, and specific oligonucleotide primers were designed to amplify the cytochrome b gene and the region which encloses the A1555

  20. Sudden Sensorineural Hearing Loss During Pregnancy:A 21 cases report%妊娠期突发性感音神经性聋21例报道

    Institute of Scientific and Technical Information of China (English)

    曾祥丽; 何建成; 李鹏; 李永奇; 岑锦添; 黎志成; 张革化

    2014-01-01

    目的:分析妊娠期突发性聋临床表现特点,探讨安全有效的治疗措施。方法分析2005年6月到2013年12月间21例妊娠期突发性聋的临床表现特点及诊疗经过、疗效。突发性聋的诊断及疗效评估参照2005年济南会议的标准,治疗过程中观察纯音听力恢复情况。治疗方案:发病3天以内中度以下低中频型聋2例,首选门诊随诊观察,其余19例选择药物治疗:①低分子右旋糖酐-40500ml静脉点滴每天1次,14天为1疗程,听力恢复则随时停药;同时口服强的松,按照1mg/kg体重开始,每日总量不超过60mg,其后每3天减少10mg;如低分子右旋糖酐-40皮试过敏,改备用方案:②葛根素注射液250ml静脉点滴及口服强的松,疗程同方案①。治疗过程由产科医生负责超声监测胎儿是否存在畸形、宫内发育迟缓、低体重。对经治病例进行半年以上的母婴健康状况随访,内容为母亲听力及肝肾功能、儿童的生长发育、智力及听力言语情况。结果治疗前纯音听力曲线包括低中频下降型6例(6耳)、平坦型7例(7耳)、全聋5例(5耳)、覆盆型1例(1耳)、峰型1例(双耳),槽型1例(1耳)。痊愈13例,显效3例,有效2例,无效3例。随访0.5~5年,母婴健康。结论妊娠期间突发性聋的治疗需谨遵孕妇用药原则,低分子右旋糖酐、葛根素及强的松治疗妊娠期间突发性耳聋的疗效显著,在治疗及随访期内未发现明显不良反应,中度以下低中频型聋有自愈倾向,发病3天以内的患者可首选门诊随诊观察。%Objectives To report clinical characteristics of sudden sensorineural hearing loss in pregnant women and dis-cuss on safe and effective treatments for this special population. Methods This is a retrospective analysis of characteristics, treatment procedures and effectiveness in 21 pregnant women with sudden deafness seen from June 2005

  1. Pharmacological reversal of endothelin-1 mediated constriction of the spiral modiolar artery: a potential new treatment for sudden sensorineural hearing loss

    Directory of Open Access Journals (Sweden)

    Arnold Wolfgang

    2005-11-01

    Full Text Available Abstract Background Vasospasm of the spiral modiolar artery (SMA may cause ischemic stroke of the inner ear. Endothelin-1 (ET-1 induces a strong, long-lasting constriction of the SMA by increasing contractile apparatus Ca2+ sensitivity via Rho-kinase. We therefore tested several Rho-kinase inhibitors and a cell-permeable analogue of cAMP (dbcAMP for their ability to reverse ET-1-induced constriction and Ca2+-sensitization. Methods The present study employed SMA isolated from gerbil temporal bones. Ca2+sensitivity was evaluated by correlating vascular diameter and smooth muscle cell [Ca2+]i, measured by fluo-4-microfluorometry and videomicroscopy. Results The Rho-kinase inhibitors Y-27632, fasudil, and hydroxy-fasudil reversed ET-1-induced vasoconstriction with an IC50 of 3, 15, and 111 μmol/L, respectively. DbcAMP stimulated a dose-dependent vasodilation (Ec50 = 1 mmol/L and a reduction of [Ca2+]i (EC50 = 0.3 μmol/L of ET-1-preconstricted vessels (1 nmol/L. Fasudil and dbcAMP both reversed the ET-1-induced increase in Ca2+ sensitivity. Conclusion Rho-kinase inhibition and dbcAMP reversed ET-1-induced vasoconstriction and Ca2+-sensitization. Therefore, Rho-kinase inhibitors or cAMP modulators could possess promise as pharmacological tools for the treatment of ET-1-induced constriction, ischemic stroke and sudden hearing loss.

  2. A study of transtympanic lidocaine and methylprednisolone injection for refractory sudden sensorineural hear-ing loss%利多卡因联合甲基强的松龙鼓室内注射治疗难治性突聋

    Institute of Scientific and Technical Information of China (English)

    杨楚; 林歆胜; 李创伟; 林炘

    2014-01-01

    目的:研究利多卡因联合甲基强的松龙鼓室内注射治疗难治性突发性耳聋的有效性及安全性。方法:选取耳鼻咽喉头颈外科住院治疗经规范常规全身用药治疗2周后无效的突发性耳聋25例,经耳内镜行利多卡因联合甲基强的松龙鼓室内注射治疗,每周2次,2周为1个疗程。治疗结束后复查纯音听阈测听及检查鼓膜情况,听力疗效评价采用平均听阈( PTA)下降≥15 dB为有效。结果:25例患者中,治疗有效的患者为8例,有效率为32%。比较治疗前后纯音听阈情况,500、1 kHz、2 kHz听阈下降明显,差异有统计学意义( P﹤0.05)。结论:利多卡因联合甲基强的松龙鼓室内注射是治疗难治性突发性耳聋的一种有效且安全的方法。%Objective To evaluate the efficacy and safety of transtympanic lidocaine and methylprednisolone injection for refractory sud-den sensorineural hearing loss. Method Studied were 25 patients who had received transtympanic lidocaine and methylprednisolone injec-tion after having failed with intravenous steroids and other medications from Aug 2008 to Mar 2012. They all had received intravenous dexa-methasone and other medicatio ns for two weeks and no improvement of hearing. The transtympanic lidocaine and methylprednisolone injec-tions were administered with oto-endoscope twice a week for 2 weeks. Hearing and tympanic membrane were monitered one month after the termination of injectio ns. Hearing improvement was defined as more than 15 dB in pure tone average( PTA). Results 8 patients had im-provement of hearing( 32%)according to the PTA. The thresholds of 500,1 000 and 2 000 Hz decreased obviously( P﹤0. 05). Conclu-sion Transtympanic lidocaine and methylprednisolone injection can be considered as a salvage treatment for refractory sudden sensorineural hearing loss.

  3. Study on The Relationship Between Glucoeoaicoid Receptors and Curative Effect of Sudden Sensorineural Hearing Loss%糖皮质激素受体与突发性聋疗效关系的研究

    Institute of Scientific and Technical Information of China (English)

    刘谦虚; 赵晓明; 汪志伟; 罗嘉龙

    2015-01-01

    Objective To investigate the relationship between expression of glucocorticoid receptor(GR) in peripheral blood mononuclear cells(PBMCs)of patients with sudden sensorineural hearing loss(SSNHL) and therapeutic effect, and the ef⁃fect of glucocorticoid(GC)to expression of GR. Methods 196 patients with SSNHL were randomly divided into two groups:pa⁃tients in groups A were treated by prednisone and Ginaton, patients in groups B were only treated by prednisone. Patients were divided into responders and nonresponders according to therapeutic effect . The mRNA express of GRαand GRβin PBMCs of every patient was detected by real time quantitative RT-PCR on pretherapy and post-therapy.The difference of GRαmRNA , GRβmRNA and GRα/GRβamong groups and between pretherapy and post-therapy was analyzed. Results 150 patients with SSNHL were GC sensitive and 46 patients were GC resistan. On pretherapy, there were GRαand GRβmRNA in PBMCs of all patients, GRαwas visibly more than GRβ, there were not obvious difference of GRαmRNA ,GRβ mRNA and GRα/GRβ in PBMCs among responders and nonresponders between two groups . There was no statistical difference of GRαmRNA between responders and nonresponders in the same group. GRβmRNA of nonresponders was significantly more than that of responders(P<0.01), GRα/GRβof nonresponders was significantly lower than that of responders(P<0.01) . On post-therapy, there were also not obvious difference of GRαmRNA ,GRβmRNA and GRα/GRβamong responders and nonre⁃sponders between two groups. GRαmRNA ,GRβmRNA and GRα/GRβwere all significantly decreased in both groups than pretherapy(P<0.01 in responders, P<0.05 in nonresponders). Conclusion GRβmRNA in PBMCs of patients with SSNHL is inversely correlative with the hearing prognosis ,whereas GRαmRNA is independent on the hearing prognosis.GC can down-regulate GRαmRNA and GRβmRNA of patient with SSNHL. Ginaton has no effect to the expression of GRαand GRβmRNA of patient with

  4. Roteiro diagnóstico e de conduta frente à perda auditiva sensorioneural genética Diagnosis routine and approach in genetic sensorineural hearing loss

    Directory of Open Access Journals (Sweden)

    Fatima Regina Abreu Alves

    2007-06-01

    determine inheritance patterns. Through a high suspicion index, syndromic cases can be diagnosed or excluded, with a careful evaluation and molecular basis tests used to better determine the hearing loss. Genetic tests and mitochondrial inheritance should be considered in any family with many affected individuals, except when the hearing loss was clearly transmitted by a male. In cases of non-syndromic SNHL, GJB2 mutation analysis must be proposed.

  5. 不同年龄段突发性聋患者临床诊疗分析%Clinical analysis of sudden sensorineural hearing loss in patients with different ages

    Institute of Scientific and Technical Information of China (English)

    王大勇; 侯志强; 刘岩; 高云; 李倩; 兰兰; 赵飞帆; 韩冰; 王秋菊

    2013-01-01

    目的 分析不同年龄阶段突发性感音神经性聋(sudden sensorineural heanngloss,简称突发性聋)患者的临床资料,了解疾病在各个年龄段的临床特征及疗效预后.方法 选取2008年6月至2010年5月住院治疗的突发性聋患者318例,按照年龄阶段分为三组:1组(青少年组,≤18岁)32例,2组(成年组,19 ~59岁)235例,3组(老年组,≥60岁)51例.对比分析不同年龄组突发性聋患者的临床表现、诱发因素及疗效预后情况.结果 青少年组28.1%(9/32)的患者有明确的病毒感染史,成年组中有18.7% (44/235)的患者在发病前有明显的情绪波动或劳累史.三组中伴发耳闷症状的患者分别占3.1%(1/32)、41.3%(97/235)和29.4%(15/51).三组中分别有62.5% (20/32)、40.0% (94/235)和33.3%(17/51)的患者为极重度听力损失,其中青少年组患者表现为极重度听力损失的比例高于其他两组(P值均<0.05).经过系统的内科治疗,三组听力改善比例分别为:31.2%(10/32)、77.4%(182/235)和64.7%(33/51),其中青少年组患者疗效较差.结论 不同年龄段突发性聋具有各自不同的临床特征和预后,其中青少年患者听力损失重、预后差.%Objective To investigate the clinical materials of sudden sensorineural hearing loss (SSNHL) in different ages of patients,and explore their clinical characteristics and prognosis.Methods A retrospective review was conducted by the clinical symptoms,predisposing factors and prognosis in SSNHL patients with different ages in the past two years (from 2008 to 2010).All patients were divided into three groups according to age,including Group 1 (0-18 years old),Group 2(19-59 years old),and Group 3(over 60 years old).Results Part of patients (28.1%) had a clear history of virus infection in Group 1.Some patients (18.7%) had obvious history of emotional fluctuations or fatigue before the onset of SSNHL.Three groups of patients with "aural fullness" symptom accounted

  6. Unusual magnetic resonance findings in two children with sudden sensorineural hearing loss Achados incomuns nas ressonâncias magnéticas de duas crianças com perda auditiva neuro-sensorial súbita

    Directory of Open Access Journals (Sweden)

    Emerson L. Gasparetto

    2005-12-01

    Full Text Available OBJECTIVE: To describe the MRI findings of two pediatric patients with sudden sensorineural hearing loss (SSHL. CASE REPORTS: Two male patients (two-year and three-months-old, and one year and four-months-old presented with sudden dumbness. Physical and neurological examinations were unremarkable besides bilateral hypoacusia. All the laboratory investigation was negative, and brain stem auditory evoked potentials showed deep bilateral deafness in both cases. MRI studies revealed normal inner ears and multifocal white matter areas of slight low signal on T1-weighted images and high signal on FLAIR images. The follow-up MRI studies and neurological examinations did not demonstrate alterations in the previous findings. CONCLUSION: Pediatric patients with SSHL may present cerebral white matter signal abnormalities at the MRI as the only finding. Further studies with larger casuistics need to be conducted to elucidate these findings.OBJETIVO: Descrever os achados de ressonância magnética (RM em dois pacientes pediátricos com perda auditiva neuro-sensorial súbita (PANS. RELATO DOS CASOS: Dois pacientes masculinos (dois anos e três meses e um ano e quarto meses de idade apresentaram-se com surdez súbita. Os exames físico e neurológico foram normais, à exceção da hipoacusia. Toda a investigação laboratorial foi normal, e os potenciais auditivos evocados do tronco cerebral demonstraram surdez profunda bilateral. Os exames de RM evidenciaram estruturas normais dos ouvidos internos e áreas multifocais de discreto hipossinal em T1 e hipersinal em FLAIR na substância branca dos hemisférios cerebrais. As RMs e os exames neurológicos de controle não demonstraram alterações nos achados prévios. CONCLUSÃO: Pacientes pediátricos com PANS podem apresentar à RM alterações de sinal na substância branca dos hemisférios cerebrais como único achado. Estudos futuros com casuísticas maiores deverão ser conduzidos para a elucidação destes

  7. Comparative study of mutation spectrums of MT-RNR1 m.1555A>G,GJB2, and SLC26A4 between familial and sporadic patients with nonsyndromic sensorineural hearing loss in Chinese Han

    Institute of Scientific and Technical Information of China (English)

    Li Qian; Ji Yubin; Han Bing; Zong Liang; Lan Lan; Zhao Yali; Wang Hongyang

    2014-01-01

    Background The mutation frequencies of three common deafness genes (MT-RNR1 m.1555A>G,GJB2,and SLC26A4) among patients with nonsyndromic sensorineural hearing loss (NSHL) were different in previous studies.Inconsistent selection criteria for recruiting patients could have led to differences in estimating the frequencies of genetic mutations thus resulting in different mutation frequencies among these studies.The aim of this study was to reveal the differences in the mutation spectrums of the three common genes between familial and sporadic Chinese Han patients.Methods Totally,301 familial probands and 703 sporadic patients with NSHL were enrolled in this study.Three genes,MT-RNR1 m.1555A>G,GJB2,and SLC26A4,were screened for mutation in our study cohort.A X2 test was performed to compare the mutation frequencies between the two groups.Results The study showed that the disease-causing mutation frequencies of MT-RNR1 m.1555A>G,GJB2,and SLC26A4 were 12.29%,14.62%,and 18.27% in familial probands and 3.56%,18.63%,and 18.92% in sporadic patients,respectively.The mutation frequency of MT-RNR1 m.1555A>G in familial probands was significantly higher than in sporadic patients (X2 test,P=0.000),while there were no significant differences in the mutation frequencies of GJB2 and SLC26A4 between the familial and sporadic groups (X2 test,P >0.05).Conclusions It is necessary to reveal the differences in gene mutation frequencies between patients of different sources or characteristics by comparative studies in order to avoid selection bias.The mutations of GJB2,SLC26A4,and MTRNR1 m.1555A>G are the most important etiological factors in Chinese Han patients,among which SLC26A4 might be the most frequent.

  8. Characteristics and curative effect analysis of sudden sensorineural hearing loss inpatients with different audiometric curve%突发性聋不同听力曲线类型的临床特征及疗效分析

    Institute of Scientific and Technical Information of China (English)

    陈平; 唐安洲; 郑明华; 黄东红; 吴正规

    2012-01-01

    目的:分析突发性聋不同听力曲线类型住院患者的临床特征及疗效,为突发性聋的诊治工作提供参考.方法:回顾性分析1 033例突发性聋住院患者的资料,比较其性别、耳侧、不同年龄段、伴发耳鸣眩晕情况、听力损失程度以及疗效在不同听力曲线类型的分布特点.结果:突发性聋患者以平坦型居多(27.24%),峰谷型最少(5.94%);性别分布:男女比例为1.3:1.0,其中上升型女性比率较下降型、平坦型、全聋型多(P<0.01).耳侧分布:平坦型双耳发病者较上升型多(P<0.01).年龄分布:平坦型在≥60岁年龄段的分布显著高于上升型(P<0.01).全聋型与其他各型、下降型与上升型相比,眩晕的发生率存在统计学差异(P<0.01).峰谷型的耳鸣发生率高于平坦型(P<0.01).听力损失程度分布:全聋型在极重度聋的分布显著高于其它各型(P<0.01),平坦型在重度聋的分布明显高于其它各型(P<0.01).治疗总有效率为51.01%,上升型、峰谷形的总有效率较下降型、平坦型、全聋型好(P<0.01);全聋型的总有效率较其他各型差(P<0.01).结论:突发性聋患者不同听力曲线的特征及疗效各不相同,其中平坦型最多,峰谷型最少;疗效以上升型和峰谷型最好,全聋型最差,听力损失程度及有否伴发眩晕和疗效密切相关.%To analyze characteristics and curative effect of sudden sensorineural hearing loss (SSHL) inpatients with different audiometric curve and provide the reference for the diagnosis and treatment of SSHL. Method Retrospective analyze of 1 033 cases of SSHL inpatients, compare the gender, the ears, the ages, with or without tinnitus and vertigo, hearing loss degree and the efficacy of distribution characteristics in different audiometric curves. Result; Inpatients with SSHL are mostly flat (27. 24%) 9 peak valley at least(5. 94%) ; Gender distribution- male to female ratio was 1. 3 : 1, audiometric

  9. Systemic steroid reduces long-term hearing loss in experimental pneumococcal meningitis

    DEFF Research Database (Denmark)

    Worsøe, Lise Lotte; Brandt, C.T.; Lund, S.P.;

    2010-01-01

    Sensorineural hearing loss is a common complication of pneumococcal meningitis. Treatment with corticosteroids reduces inflammatory response and may thereby reduce hearing loss. However, both experimental studies and clinical trials investigating the effect of corticosteroids on hearing loss have...

  10. 鼓室注射地塞米松治疗糖尿病伴突发性耳聋的临床研究%Intratympanic dexamethasone injection treatment for sudden sensorineural hearing loss in patients with diabetics

    Institute of Scientific and Technical Information of China (English)

    付发祥; 宋蕾

    2012-01-01

    目的 观察鼓室内注射地塞米松治疗糖尿病伴突发性耳聋的疗效.方法 将46例Ⅱ型糖尿病伴突发性耳聋患者按其意愿分为治疗组(21例)和对照组(25例),每组均采用扩血管、营养神经及胰岛素降糖等治疗;治疗组加用经鼓室注射地塞米松(5 g/L),隔日注射1次,共5次,疗程结束(10d)后复查纯音听阈.结果 治疗组未出现化脓性中耳炎、鼓膜穿孔、听力下降,其总有效率(15/21,71.4%)明显优于对照组(10/25,40.0%),两组差异具有统计学意义(P<0.05).结论 鼓室注射地塞米松治疗糖尿病伴突发性耳聋有效,它可避免全身激素用药的不良反应,作为糖尿病伴突发性耳聋患者的初始治疗是一个合理的选择.%Objective To investigate the effect of intratympanic dexamethasone injection for sudden hearing loss in patients with diabetes. Methods 46 diabetics with sudden hearing loss were assigned to treatment group (n = 21) and control group ( n = 25 ). Simultaneously vasodilation, neurotrophy and insulin hypoglycemia were administered in both groups. Patients in treatment group were additionally managed with intratympanic dexamethasone (5 g/L) injection five times within 10 days. Pure tone test was conducted after intervention. Results The overall effective rates of the treatment group and the control group were 71.4% and 40. 0% respectively, and the difference was statistically significant ( P < 0. 05 ). No unexpected adverse events such as acute otitis media, perforated tympanic membrane and worsening in hearing occurred during the injection and follow-up period in the treatment group. Conclusion Intratympanic dexamethasone injection is an effective treatment for sudden hearing loss in patients with diabetes and can avoid undesirable side effects. Therefore, intratympanic dexamethasone injection may be a reasonable alternative as an initial treatment of sudden hearing loss in patients with diabetes.

  11. 迟发性显性遗传性感音神经性聋的听力和言语表现及其对策%Manifestations and Treatments of Hearing and Speech in Patients with Delayed Dominant Hereditary Sensorineural Deafness

    Institute of Scientific and Technical Information of China (English)

    李富德; 陈家萍; 周祥宁

    2001-01-01

    To investigate the condition of the hearing and speech in subjects from 2 families with delayed dominant hereditary sensorineural deafness. Methods: The investigation of deafness heredity and the examination of systemic audiology were made in the 2 families. Results: The examination of pure tone hearing threshold showed that hearing threshold in all frequency ranges were severely elevated, the curve of hearing threshold revealed the descending type in 6 cases of the 2 families,among whom there were only residual hearings at low frequency in 3 ears of 2 cases,The ages of onset of hearing loss of the 2 families have some characteristics: the onset became younger, the course was shorter, the degree of deafness was worse from generation to generation. The earlier the onset of hearing loss was,the worse the speech function was. Conclusion:Ge netic counseling and health education are important in reducing incidence of hereditary hearing loss. Hearing monitoring should be carried out periodically for children with history of hereditary hearing loss in their families. Hearing aids should be prescribed for probands as soon as hearing loss is verified. Speech rehabilitation is also advised when indicated.%探讨2家系迟发性显性遗传性感音神经性聋的听力和言语情况。方法:对2家系进行耳聋遗传调查和系统的听力学检查。结果:2家系6例纯音听阈检查示全频程听阈重度升高,听阈曲线呈缓降型,其中2例3耳仅低频听力残存。2家系耳聋发生年龄有逐代提前、代代相传、病程缩短、耳聋程度加重的特征。发生耳聋的年龄愈小,言语功能愈差。结论:应加强对遗传性聋的咨询、指导以及宣传工作。尽力减少或控制遗传性耳聋的发生率,对有家族遗传史者应定期进行听力学监测,对已发生耳聋者应及早配戴助听器并进行适当的言语训练。

  12. Characteristics and application of inner ear CT for sensorineural hearing loss in children%儿童感音神经性耳聋20例内耳多层螺旋CT特征及应用分析

    Institute of Scientific and Technical Information of China (English)

    霍亮; 史贻芳; 王华

    2012-01-01

    目的 探讨儿童感音神经性耳聋(SNHL)内耳多层螺旋CT(MSCT)特点及其对诊断的价值.方法 选取2008年1月至2010年12月中国医科大学附属盛京医院经脑干听觉诱发电位(BAER)诊断儿童SNHL患儿65例,均行内耳MSCT扫描,然后行冠状面多平面重建(MPR).结果 20例(33只耳,45例次)存在内耳畸形,其中12只耳多种畸形并存,包括耳蜗畸形伴内耳道畸形5只耳;耳蜗畸形伴前庭导水管扩大3只耳;前庭畸形伴内耳道畸形2只耳;半规管畸形伴前庭导水管扩大1只耳;内耳道畸形伴前庭导水管扩大1只耳.45例次畸形中耳蜗畸形10例次[包括Michel型1例次、共同腔畸形2例次、耳蜗未发育1例次、耳蜗发育不全1例次、不完全分隔Ⅰ型2例次、不完全分隔Ⅱ型(Mondini畸形)3例次]、前庭畸形7例次、半规管畸形5例次、内耳道畸形8例次、前庭导水管扩大15例次.结论 根据MSCT检查结果显示多数SNHL患儿存在内耳畸形.内耳横断面MSCT扫描和冠状面MPR可对儿童先天性SNHL内耳畸形进行全面评估,从而为进一步指导治疗及预后提供有力依据.%Objective To evaluate the characteristics of inner ear multi-slice computed tomography (MSCT) in pediat-ric sensorineural hearing loss (SNHL) and feasibility and usability of diagnosis of SNHL. Methods Sixty-five patients have been diagnosed with sensorineural hearing loss (SNHL) by Brainstem Auditory Evoked Response (BAER). Inner ear MSCT scan and coronal multiplanar reformation (MPR) reconstruction were done in all cases. Results This study showed that 20 cases (33 ears,45 case times) were with inner ear malformations and 12 ears with two different malformations, including 5 ears with cochlear and internal auditory canal (IAC) malformations, 3 ears with cochlear and vestibu-lar malformations, 2 ears with vestibular and IAC malformations, 1 ear with semicircular canal and vestibular malformations, 1 ear with internal auditory

  13. Determination of serum visfatin and retinol binding protein 4 ( RBP4 ) in patients with idiopathic sudden sensorineural hearing loss and its clinical significance%突发性耳聋患者内脂素和RBP4含量变化的研究

    Institute of Scientific and Technical Information of China (English)

    牛善利; 黄友敏; 周永勤

    2012-01-01

    Objective To study the role and clinical significance of serum visfatin and retinol binding protein 4 (RBP4) in idiopathic sudden sensorineural hearing loss by measuring the change of their levels in the patients with idiopathic sudden sensorineural hearing loss.Methods The levels of visfatin and RBP4 were determined by ELISA method in the 102 idiopathic sudden sensorineural hearing loss patients who were observed at two different time points ( before and after treatment),and thirty-five patients with other neurologic diseases (20 with sciatica,16 with trigeminal neuralgia) and thirty healthy people were used as control.Results The levels of visfatin and RBP4 in the serum of patients with idiopathic sudden sensorineural hearing loss after treatment [Visfatin (24.26 ± 2.17 ) μg/L; RBP4 (46.65 ± 5.26 ) mg/L]were markedly higher than the group with other neurologic diseases [Visfatin ( 20.67 ± 2.14 ) μ g/L; RBP4(34.37 ±5.73)mg/L] and the healthy control group[Visfatin(17.61 ±2.45) μg/L; RBP4 (24.82 ±5.24)mg/L] ( t =10.38,10.41,12.16,15.06,P <0.01),and it was significantly less than that before treatment [Visfatin(32.24 ± 2.37) μ /L; RBP4 ( 57.43 ± 6.19 ) mg/L] ( t =17.25,15.12,P < 0.01 ).The levels visfatin and RBP4 in serum of severe group with idiopathic sudden sensorineural hearing loss [Visfatin ( 36.52 ± 2.46 ) μg/L; RBP4 (67.17 ± 5.92 ) mg/L] were markedly higher than those in the moderate group[Visfatin(28.92 ±2.26)μg/L; RBP4 (55.34±5.95)mg/L]( t =11.21,11.17,P <0.01).The levels visfatin and RBP4 in serum of moderate group were markedly higher than those in the mild group [Visfatin ( 25.31 ± 2.32 ) μg/L; RBP4 ( 47.48 ± 5.82 ) mg/L],all these differences were statistically significant( t =10.43,10.49,P <0.01 ).There was a positive correlation between visfatin and RBP4 in patients with idiopathic sudden sensorineural hearing loss ( r =0.68,P < 0.01 ).Conclusions The levels of serum visfatin and RBP4 have instructive significance in

  14. Clinical and prognostic analyses of juvenile sudden sensorineural hearing loss%青少年突发性耳聋的临床特征及疗效分析

    Institute of Scientific and Technical Information of China (English)

    王大勇; 侯志强; 刘岩; 高云; 赵飞帆; 纵亮; 兰兰; 王秋菊

    2013-01-01

    Objective To explore the clinical profiles of juvenile sudden sensorineural hearing loss (JSSNHL) and examine its clinical characteristics and prognosis.Methods A retrospective review was conducted for the clinical symptoms,audiological characteristics,hematological indices and proggosis in JSSNHL during the past 2 years (from June 2008 to November 2010).All patients were divided into 2 groups according to age,that is group childhood (A,0-12 years old) and group adolescence (B,13-18 years old).Results JSSNHL patients were rarely associated with "aural fullness" symptoms.Two groups of patients with "tinnitus" symptom accounted for 88.2% and 89.5%.Those with "vertigo" symptom accounted for 47.1% and 44.4% respectively.Most patients (81.6%) showed severe and profound hearing loss.The most common types of audiometric curve were flat and total deafness.Some obvious differences existed between two groups in hematological indices,such as platelet count,concentrations of clcctrolytc ions,mean corpuscular volume and mean corpuscular hemoglobin.Almost half of them (42.1%) improved hearing level during systemic medical treatment.The patients of two groups showed no significant differcnce in efficacies.And the hearing enhancement degree of patients in group B was more apparent than that of group A.Conclusions JSSNHL has different clinical features in different age groups.And the outcomes of personalized treatment regimens may be further improved through classification and grading.%目的 分析青少年突发性耳聋住院患者临床资料,了解疾病在儿童期和青春期的临床特征及转归规律.方法 选取2008年6月-2010年11月在解放军总医院耳内科住院治疗的0~18岁青少年突发性耳聋患者35例(38耳),按照年龄阶段分为2组:儿童期患者(0 ~12岁)17例(19耳),青春期患者(13 ~ 18岁)18例(19耳).对比两组患者临床表现、听力学特征、血液学指标以及疗效等情况.结果 青少年突发性耳

  15. Factors Associated with Sudden Sensorineural Hearing Loss of the In-patients between 2001 and 2011%2001~2010年突发性聋患者相关因素分析

    Institute of Scientific and Technical Information of China (English)

    马永忠; 曾薇; 冯志谦; 黄桂球; 陈美珍

    2012-01-01

    Objective To study related factors of the inpatients with sudden sensorineural hearing loss (SSHL) in nearly ten year, to summarize the characteristics of its occurrence, and to provide the scientific evidence for clinical application. Methods 779 ears of 717 inpatients with SSHL from January, 2001 to December,2010 were reviewed retrospectively for the ages, seasonal variations, genders and affected ear occurrence. Results The inpa tients with SSHL showed a rising trend, especially for the past three years. The group of the youth people (19-'44 years) had the highest ratio, with 374 cases, accounting for 52. 16% , and followed the middle-aged group (45-'59 years) with 189 cases, accounting for 26. 36%. The number of inpatients in autumn (0~10 months) with 262 ca ses, is the largest throughout the year, accounting for 36. 54% , and the next was the spring group (2~4 months) with 206 cases, accounting for 28. 73%. Male patients of 372 cases accounted for 51. 88% while the female of 345 cases for 48. 12%. The left-ear SSHL involved 346 cases, accounting for 48. 26% and the right-ear 309 cases for 43. 10%. The bilateral group of 62 cases made up for 8. 65%. Conclusion The incidence of SSHL is increasing year by year. It is most common among the young people, followed by the middle-aged. More inpatients were in au tumn than the other seasons, followed by spring. There are no differences between genders, left and right ears. It is important to carry out the public awareness of the disease prevention and teratment,especially in certain seasons and for certain age groups.%目的 分析近10年来突发性聋患者的相关因素,总结其发病特点.方法 回顾性分析2001年1月~2010年12月间717例(779耳)突发性聋患者的临床资料,分析其发病年龄构成比、季节特点、性别构成比及患耳侧别构成比.结果 突聋患者呈逐年增加的趋势,尤其近3年增加明显;青年人(19~44岁)构成比最高,共374例,占52.16%,

  16. Application of Cochlear Nerve Magnetic Resonance Imaging in Sensorineural Hearing Loss%蜗神经磁共振成像在感音神经性聋中的应用

    Institute of Scientific and Technical Information of China (English)

    张晓晶; 娄昕; 吴南洲; 王大勇; 王秋菊

    2012-01-01

    目的 探讨蜗神经磁共振成像在感音神经性聋(SNHL)中的应用价值.方法 采用GE TwinExct 1.5T磁共振扫描仪对130例(260耳)SNHL患者进行蜗神经磁共振成像及内耳水成像.蜗神经成像序列为斜矢状位FRFSE T2加权像,内耳水成像为3D FIESTA序列.结果 90例大于等于18岁的患者中,85例170耳显示蜗神经、迷路正常;1例2耳前庭导水管扩大;1例1耳蜗神经信号缺失;3例6耳蜗神经细小;40例小于18岁的患者中,19例38耳显示蜗神经、迷路正常;2例3耳Michel畸形;6例12耳Mondini畸形;1例2耳共腔畸形;12例24耳前庭导水管扩大;21例畸形中7例14耳蜗神经信号缺失.2例4耳显示内听道狭窄伴蜗神经细小.结论 磁共振内耳成像对诊断SNHL有着重要的价值,对判断患者内耳蜗神经发育情况及内耳畸形有着不可替代的作用,是这类患者进行人工耳蜗植入术前必要检查.%Objective To evaluate the value of the cochlear nerve magnetic resonance imaging in evaluation of sensori-neural hearing loss (SNHL). Methods One hundred and thirty patients (260 ears) with SNHL underwent imaging of the cochlear nerve and internal auditory canal (IAC) on a GE TwinExct 1.5T MR scanner. The cochlear nerve was scanned with the oblique sagittal FRFSE T2 weighted sequence, while the IAC was imaged with the 3D Fiesta sequence. Results Among 90 patients who were 18 years old or older, 85 (170 ears) showed normal cochlear nerve and labyrinth; 1 (2 ears) showed large vestib-ular aqueduct; 1 (1 ear) showed absence of cochlear nerve signal; and 3 (6 ears) showed small cochlear nerves. Among 40 patients who were younger than 18 years, 19 (38 ears) showed normal cochlear nerves; 2 (3 ears) showed Michel malformation; 6 (12 ears) showed Mondini malformation; 1 (2 ears) showed common cavity malformation; and 12 (24 ears) showed large vestibu-lar aqueduct. Among 21 cases of malformations, 7 (14 ears) showed missing cochlear nerve signal; and 2 (4 ears

  17. Severe Sensorineural Hearing Loss in Children with Cochlear Implants Causes of the Failure before the ECG and Nursing%重度感音聋患儿人工耳蜗植入术前心电图检查失败原因分析及护理对策

    Institute of Scientific and Technical Information of China (English)

    于莉; 刘伟萍; 李爱军

    2013-01-01

    Objective:To investigate severe sensorineural hearing loss in children with cochlear implants before ECG failure and develop appropriate nursing measures. Methods:A retrospective analysis of our hospital in February 2011~February 2012 period 428 cases (236males, 192females) with severe sensorineural hearing loss in children with cochlear implants preoperative clinical and ECG data, statistics, analysis and classification severe sensorineural hearing loss in children with preoperative ECG failure cases causes of the failure to develop nursing measures. Results:Preoperative ECG successful children with 188 cases, accounting for 44%;quadratic successful children with 232 cases, accounting for 54.2%;three successful children with eight cases, accounting for 1.87%;6 cases in 428 cases diagnosed with long QT syndrome, inoperable. Failure:(1) children with parents and children on a larger preoperative ECG lack of understanding of the necessity and importance. (2) ECG before taking on the role of drugs and side effects do not. (3) environmental factors and children with their own factors.Conclusion:Compliance behavior of parents of children with poor children is not fully implemented by your doctor right preoperative ECG preparation before;severe sensorineural hearing loss in children with cochlear implants before ECG targeted for parents of children and children with nursing intervention is necessary.%目的:探讨重度感音聋患儿人工耳蜗植入术前心电图检查失败的原因和制定相应的护理对策的措施。方法:回顾性分析我院2011年2月~2012年2月期间收治行人工耳蜗植入术重度感音聋患儿428例(男236例,女192例)术前的临床资料和心电图,统计、分类及分析重度感音聋患儿术前心电图检查失败病例的失败原因,制定相应的护理对策。结果:术前心电图检查一次成功的患儿有188例,占44%;二次成功的患儿有232例,占54.2%;三次成功的患儿有8

  18. Ranking Hearing Aid Input-Output Functions for Understanding Low-, Conversational-, and High-Level Speech in Multitalker Babble

    Science.gov (United States)

    Chung, King; Killion, Mead C.; Christensen, Laurel A.

    2007-01-01

    Purpose: To determine the rankings of 6 input-output functions for understanding low-level, conversational, and high-level speech in multitalker babble without manipulating volume control for listeners with normal hearing, flat sensorineural hearing loss, and mildly sloping sensorineural hearing loss. Method: Peak clipping, compression limiting,…

  19. Genes and Syndromic Hearing Loss.

    Science.gov (United States)

    Keats, Bronya J. B.

    2002-01-01

    This article provides a description of the human genome and patterns of inheritance and discusses genes that are associated with some of the syndromes for which hearing loss is a common finding, including: Waardenburg, Stickler, Jervell and Lange-Neilsen, Usher, Alport, mitochondrial encephalomyopathy, and sensorineural hearing loss. (Contains…

  20. Telling stories and hearing voices: narrative work with voice hearers in acute care.

    Science.gov (United States)

    Place, C; Foxcroft, R; Shaw, J

    2011-11-01

    Mental health nurses do not always feel at ease talking in detail with voice hearers about their experiences. Using the approach of Romme and Escher, a project was developed to support staff on an acute inpatient ward to explore voice hearing with patients. Romme and Escher suggest that a person's own understanding of their voices and their meaning is the key to recovery. Working together, the nurse helps voice hearers construct a narrative that tells the story of their voices. Examples from the narratives show how they can help increase understanding of a person's voices, and how the mental health nurse in acute care can realistically offer therapeutic interventions that may help a person towards recovery.

  1. 突发性耳聋患者HMGB1和VE-cadherin含量变化的意义%Determination of Serum HMGB1 and Vascular Endothelial Cadherin in Patients with Idiopathic Sudden Sensorineural Hearing Loss and Its Clinical Significance

    Institute of Scientific and Technical Information of China (English)

    牛善利; 黄友敏; 周永勤

    2011-01-01

    Objective To study the role and clinical significance of serum high mobility group box-1 ( HMGB1 ) and vascular endothelial cadherin(VE-cadherin) in idiopathic sudden set cural hearing loss. Methods The levels HMGB1 and VE-cadherin were determined by ELISA method in 102 patients with idiopathic sudden sensorineural hearing loss( group A ) ,35 patients with other neurologic diseases( group B,20 cases with sciatica, 16 cases with trigeminal neuralgia) and 30 healthy people( group C, as normal control ). Results The serum levels HMGB1 and VE-cadherin in group A were markedly higher than those of other two groups(P <0.01 ); and the levels of HMGB1 and VE-cadherin in group A decreased obviously as compared to the level before the treatment( P <0 01 ). There was a correlation between HMGB1 and VE-cadherin in patients with idiopathic sudden sensorineural hearing loss( r = 0.68 ,P < 0.01 ). Conclusion The serum levels of HMGB1 and VE-cadherin have instructive significance in the treatment and prognosis estimating of patients with idiopathic sudden sensorineural hearing loss.%目的 探讨突发性耳聋患者血清高迁移率蛋白-1(HMGB1)和血管内皮细胞钙黏蛋白(VE-cadherin)的含量变化,及其在突发性耳聋发生过程中的作用和意义.方法 采用酶联免疫(ELISA)法检测血清HMGB1和VE-cadherin含量:检测102例突发性耳聋患者、35例其他疾病对照组和30例正常健康对照组的血清HMGB1和VE-cadherin含量,并比较治疗前后血清HMGB1和VE-cadherin的测定结果.结果 突发性耳聋患者治疗前血清HMGB1和VE-cadherin含量较两对照组显著升高(P<0.01);治疗后恢复组患者HMGB1和VE-cadherin含量明显降低.突发性耳聋患者血清HMGB1和VE-cadherin含量之间呈正相关(r=0.68,P<0.01).结论 血清HMGB1和VE-cadherin水平的变化与突发性耳聋病情严重程度密切相关.

  2. Perda auditiva neurossensorial súbita idiopática: evolução na presença de hipertensão arterial sistêmica, diabetes melito e dislipidemias Idiopathic sudden sensorineural hearing loss: evolution in the presence of hypertension, diabetes mellitus and dyslipidemias

    Directory of Open Access Journals (Sweden)

    Jayson Nagaoka

    2010-06-01

    Full Text Available Estudo retrospectivo com o objetivo de avaliar a interferência das doenças associadas na evolução e prognóstico da perda auditiva neurossensorial súbita idiopática. MATERIAL E MÉTODO: Estudo caso controle. Trinta e cinco pacientes com perda auditiva neurossensorial súbita idiopática divididos em dois grupos, um com doenças associadas (hipertensão arterial sistêmica, diabetes melito e dislipidemias e outro sem doenças associadas. Avaliação das variáveis: idade, sexo, doença associada, presença de zumbido, tontura e plenitude aural, presença de microangiopatia cerebral na ressonância magnética, alteração no fundo de olho, tempo de início de tratamento, taxa de melhora auditiva, evolução do índice do reconhecimento da fala. Dados avaliados estatisticamente. RESULTADOS: O grupo com doença associada, quando comparado ao grupo sem doença associada, apresenta idade mais elevada, maior número de pacientes com microangiopatia cerebral na ressonância magnética e recuperação mais lenta do índice de reconhecimento da fala. CONCLUSÃO: Perda auditiva neurossensorial súbita idiopática na presença da hipertensão arterial sistêmica, diabetes melito e dislipidemias, em indivíduos mais velhos, está associada a uma maior prevalência de achados de microangiopatias cerebrais nos exames de ressonância magnética, e à recuperação auditiva mais lenta na melhora do índice de reconhecimento da fala.Retrospective study aiming at evaluating the interference of associate diseases in the evolution and prognosis of idiopathic sudden sensorineural hearing loss. MATERIALS AND METHODS: Case-Control Study. Thirty-five patients with idiopathic sudden sensorineural hearing loss were divided in two groups, one of them with associate diseases (hypertension, diabetes mellitus and dyslipidemias, and another one without co-occurrence of such diseases. The groups were evaluated regarding: age, gender, associate diseases, presence of

  3. Relationship between leukocyte count and its genera in peripheral blood with incipient hearing loss and prognosis in patients with sudden sensorineural hearing loss%突发性耳聋患者外周血白细胞计数及分属与初发听力损失和预后的相关性

    Institute of Scientific and Technical Information of China (English)

    李璠; 李峰; 鲁建光

    2015-01-01

    目的 探讨突发性耳聋(sudden sensorineural hearing loss,SSHL)患者外周血白细胞计数及分属与初发听力损失程度和预后的相关性.方法 SSHL患者70例,常规进行血液学检查,记录外周血白细胞总数、中性粒细胞百分比、淋巴细胞百分比等项指标.分别采集治疗前后的纯音测听结果,观察白细胞计数和分属与患者初发听力损失程度和疗效的关系,以30例健康体检者的相关参数作为对照.结果 SSHL组患者外周血白细胞计数、中性粒细胞百分比明显高于健康对照组,淋巴细胞百分比明显低于健康对照组(P<0.05);SSHL组患者白细胞计数和分属与初发听力损失程度无明显相关性(P>0.05),而外周血白细胞计数升高、中性粒细胞百分比升高及淋巴细胞百分比降低的患者治疗效果则明显较差(P<0.05).结论 SSHL患者发病前可能存在感染因素,外周血白细胞计数和中性粒细胞百分比升高、淋巴细胞百分比降低可能提示患者预后不良.

  4. Effects of hearing loss on the subcortical representation of speech cues

    OpenAIRE

    Anderson, Samira; Parbery-Clark, Alexandra; White-Schwoch, Travis; Drehobl, Sarah; Kraus, Nina

    2013-01-01

    Individuals with sensorineural hearing loss often report frustration with speech being loud but not clear, especially in background noise. Despite advanced digital technology, hearing aid users may resort to removing their hearing aids in noisy environments due to the perception of excessive loudness. In an animal model, sensorineural hearing loss results in greater auditory nerve coding of the stimulus envelope, leading to a relative deficit of stimulus fine structure. Based on the hypothesi...

  5. Three different routes of administration in the treatment of sudden sensorineural hearing loss.LU Na. Department%三种不同给药途径治疗突发性感音神经性耳聋的效果对比

    Institute of Scientific and Technical Information of China (English)

    卢娜

    2015-01-01

    Objective To explore the best route of administration in the treatment of sudden sensorineural hearing loss. Methods According to the best route of administration.210 sudden sensorineural hearing loss patients were divided in-to the venous group(70 patients injected dexamethasone via vein),the tympanic group(70 patients injected methylpred-nisolone into tympanic cavity),and the retroauricular group (70 patients injected methylprednisolone subperiosteally in the mastoid).Results The cure and effective rates of the three groups were 29.58%,64.79%,35.21%,80.28%, and 64.79%,83.10%,respectively.As for thecure rate,there were significant differences between the vein group and the retroauricular group(P 0.05).For the effective rates,there were sig-nificant differences between the vein group and the retroauricular group(P 0.05).Conclusion injecting methylprednisolone subperiosteally in the mastoid shows a high cure rate and stable effective rate sudden sensorineural hearing loss.%目的:探讨治疗突发性感音神经性聋的最佳给药途径。方法将突发性感音神经性聋患者210例(213耳)分为静脉组70例(71耳),给予静脉注射地塞米松;鼓膜穿刺组70例(71耳),给予鼓室内注射甲强龙;耳后注射组70例(71耳),给予耳后乳突区骨皮质下注射甲强龙。结果静脉组、鼓膜穿刺组、耳后注射组三组痊愈率、总有效率分别为29.58%、64.79%,35.21%、80.28%,64.79%、83.10%。三组痊愈率经统计学处理,静脉组与鼓膜穿刺组差异无统计学意义(P >0.05),静脉组与耳后注射组差异有统计学意义(P <0.01),鼓膜穿刺组与耳后注射组差异有统计学意义(P <0.01);总有效率静脉组与鼓膜穿刺组差异有统计学意义(P <0.05),静脉组与耳后注射组差异有统计学意义(P <0.05),鼓膜穿刺组与耳后注射组差异无统计学意义(P >0.05)。结论

  6. Benefit of Analog, Programmable and Digital Hearing Aids

    OpenAIRE

    Jamileh Fatahi; Mansoureh Adel Ghahraman; Azadeh Ebrahimi; Faranak Ehsani; Samaneh Pourhadi

    2006-01-01

    Background and Aims: As the hearing aid technology progressively promotes toward replacing analog hearing aids with digital and programmable ones, comparison of the patient satisfaction of those kinds of hearing aids by means of a valuable tool seems so necessary. So, the aim of this study was to compare self-reported benefit of analog, digitally controlled programmable and digital hearing aids for reducing disability caused by hearing impairment in mild to severe sensorineural hearing impair...

  7. Acute necrosis after Gamma Knife surgery in vestibular schwannoma leading to multiple cranial nerve palsies.

    Science.gov (United States)

    Kapitza, Sandra; Pangalu, Athina; Horstmann, Gerhard A; van Eck, Albert T; Regli, Luca; Tarnutzer, Alexander A

    2016-08-01

    We discuss a rare acute complication after Gamma Knife therapy (Elekta AB, Stockholm, Sweden) in a single patient. A 52-year-old woman presented with vertigo, facial weakness and hearing loss emerging 48hours following Gamma Knife radiosurgery for a right-sided vestibular schwannoma. Neurological examination 6days after symptom onset showed right-sided facial palsy, spontaneous left-beating nystagmus and pathologic head-impulse testing to the right. Pure-tone audiogram revealed right-sided sensorineural hearing loss. A diagnosis of acute vestibulocochlear and facial neuropathy was made. Brain MRI demonstrated focal contrast sparing within the schwannoma, likely related to acute radiation necrosis. Acute multiple cranial neuropathies of the cerebellopontine angle after Gamma Knife treatment should raise suspicion of acute tissue damage within the schwannoma and should result in urgent MRI. Treatment with steroids may be considered based on accompanying swelling and edema. PMID:26947104

  8. Aspects of Hearing Aid Fitting Procedures

    OpenAIRE

    Metselaar, Mick

    2010-01-01

    textabstractSensorineural hearing loss is a common and chronic disorder that affects almost ten percent of the world population. In the Netherlands, it is also the major disorder in the working population [NCvB, 2008]. Hearing loss leads to restriction in the interaction with others and withdrawal from participation in (social) activities. Due to the size of the problem and the vast impact on the function, hearing rehabilitation is an important issue. Although hearing rehabilitation focuses o...

  9. Mechanisms of Sensorineural Cell Damage, Death and Survival in the Cochlea

    Directory of Open Access Journals (Sweden)

    Allen Frederic Ryan

    2015-04-01

    Full Text Available The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well as the survival signaling pathways that can provide endogenous protection and tissue rescue. These data have primarily been generated in hearing loss not directly related to age. However, there is evidence that similar mechanisms operate in presbycusis. Moreover, accumulation of damage from other causes can contribute to age-related hearing loss. Potential therapeutic interventions to balance opposing but interconnected cell damage and survival pathways, such as antioxidants, anti-apoptotics, and pro-inflammatory cytokine inhibitors, are also discussed.

  10. Prevalence of sensorineural deafness in habitual mobile phone users

    Directory of Open Access Journals (Sweden)

    G C Sahoo

    2011-01-01

    Full Text Available Introduction : Mobile phone usage is widespread and concerns have been raised on the safety of its long-term usage. The electromagnetic fields emitted from mobile can penetrate skull and deposit energy 4-6 cm into the brain resulting in heating of the tissue. In this study, we explore a possible relationship between prolonged mobile phone usage and sensorineural deafness. Materials and Methods: The study was conducted in a medical college situated in rural India. A total of 100 persons between the age group of 20-45years using mobile phone for at least 5 years are selected and screened for sensorineural deafness. Use of cellular phones was assessed by a questionnaire. Mean number of daily calls and minutes were asked for to calculate the cumulative use in hours for all years. The most frequently used ear during cellular phone calls was noted, or whether both ears were used equally. Otoscopic examinations were performed by an otolaryngologist before testing in order to rule out any external or middle ear pathology that could affect audiometric measurements. The hearing levels of subjects were tested using pure tone audiometry. Results : One hundred subjects who are habitual mobile phone users were screened by pure tone audiometry. It is found that the prevalence of sensorineural deafness was 3% and there is a linear relationship between the duration of mobile phone use and the degree of the severity of deafness. Conclusion : The prevalence of sensorineural deafness in our study in habitual mobile users is 3%. It is not clearly known whether mobile phone use is the direct cause of deafness in these subjects but the absence of other causes might point towards its etiological role.

  11. Sudden hearing loss subsequent to diarrhea: what is the missing link?

    Science.gov (United States)

    Jafari, Gholamali; Hosseini, Seyed Mohammadreza; Akhondzadeh, Shahin

    2014-01-08

    Sudden sensorineural hearing loss (SSNHL) is a debilitating condition with an incidence of nearly 20 per 100,000 in populations. Metronidazole-induced ototoxicity is an extremely rare etiology of SSNHL. In this report, we describe a young female with bilateral SSNHL due to oral use of metronidazole. A 23 years old female presented to the emergency department with acute bilateral hearing loss. We found out that her hearing loss had started 4 days after initiation of metronidazole which was administered for treatment of diarrhea. This case report shows that physicians should be aware of the uncommon side effects while prescribing metronidazole to patients in order to manage the possible adverse events on time.

  12. 综合干预对突发性感音神经性聋患者焦虑抑郁情绪及生活质量的影响%The effect of comprehe nis ve intervention on anxiety, depression and quality of life of patients with sudden sensorineural hearing loss

    Institute of Scientific and Technical Information of China (English)

    孙丽; 任秀平; 林乃芬; 杜云

    2015-01-01

    目的:通过对突发性感音神经性聋患者进行综合干预,分析其对焦虑、抑郁情绪及生活质量(QOL)的影响。方法将90例突发性感音神经性聋患者随机分为干预组(45例)和对照组(45例),均接受正规的突发性感音神经性聋常规治疗。对照组按照突发性感音神经性聋护理常规进行护理和健康指导;干预组在此基础上增加认知、行为、家庭社会支持等综合干预。采用Zung焦虑自评量表( SAS )、抑郁自评量表( SDS )和生活质量指数评定量表( QOL)分别于入院3天内及出院前对两组患者进行评估。结果入院3天内两组患者SAS、SDS及QOL评分比较差异均无统计学意义( P>0.05);出院前干预组SAS评分(42.58±8.06)分,较对照组评分(54.28±11.06)分显著下降,差异有统计学意义(t=-4.26,P<0.01),SDS评分(44.13±6.75)也较对照组(52.25±11.26)下降,差异有统计学意义(t=-3.74,P<0.01);生活质量干预组各维度评分显著高于对照组,差异均有统计学意义( P<0.01)。结论护士可根据SAS、SDS对突发性感音神经性聋患者进行评定,实施综合干预,从而可显著改善患者的焦虑、抑郁情绪状态,促进患者康复,全面提高患者的生活质量。%Objective To analyze the effect of comprehensive intervention on anxiety, depression and quality of life of patients with sudden sensorineural hearing loss.Methods A total of 90 cases of sudden sensorineural hearing loss patients were randomly divided into intervention group ( n=45 ) and control group ( n=45 ) .All the patients were given the standard conventional sudden sensorineural hearing loss treatments.The patients of control group were given the regular deafness nursing and health direction, while beyond that the patients of intervention group were given the com-bined comprehensive intervention treatment of cognition

  13. 鼓室置管灌注甲泼尼龙治疗难治性突发性聋的听力疗效再分析%Revisiting efficacy of intratympanic methylprednisolone perfusion on hearing in refractory sudden sensorineural hearing loss: a prospective, control study

    Institute of Scientific and Technical Information of China (English)

    戴艳红; 佘万东; 杜小平; 俞晨杰; 陈峰; 王俊国; 秦小明

    2010-01-01

    目的 探讨经耳道鼓室置管灌注甲泼尼龙治疗难治性突发性聋(sudden sensorineural hearing loss,SSNHL)的安全性和有效性.方法 对常规治疗至少一个疗程(10天)无效的SSNHL,根据病人的意愿分成灌注组和对照组分别继续治疗10天.灌注组给予鼓室置管灌注甲泼尼龙+常规治疗,对照组继续常规治疗,比较治疗结束后3个月时两组的听力改善结果.结果 灌注组26例和对照组23例,两组的有效率分别是50.0%和21.7%,继续治疗前后PTA改善分别是16.7 dB和9.2 dB,两组比较灌注组的有效率高于对照组(P=0.041); 若仅将发病至继续治疗的时间间隔≤60天的病例纳入分析,则灌注组为21例,对照组仍为23例,有效率分别是61.9%和21.7%,PTA改善分别为20.2 dB和9.2 dB,灌注组均优于对照组(P_(有效率)=0.007,P_(PTA 改善)=0.011);鼓室灌注前后低频区(0.25 kHz,0.5 kHz)、中频区(1 kHz、2 kHz)和高频区(4 kHz、8 kHz)的听阈分别改善19.8 dB、16.0 dB和13.4 dB,低频区听力改善大于高频区(P=0.046).结论 鼓室置管灌注甲泼尼龙联合常规治疗用于难治性SSNHL是安全的、有效的,疗效优于继续常规治疗,且低频区的听力改善优于高频区,发病后宜尽早采用.

  14. Aspects of Hearing Aid Fitting Procedures

    NARCIS (Netherlands)

    R.M. Metselaar (Mick)

    2010-01-01

    textabstractSensorineural hearing loss is a common and chronic disorder that affects almost ten percent of the world population. In the Netherlands, it is also the major disorder in the working population [NCvB, 2008]. Hearing loss leads to restriction in the interaction with others and withdrawal f

  15. Is Hearing Impairment Associated with Rheumatoid Arthritis?

    DEFF Research Database (Denmark)

    Emamifar, Amir; Bjoerndal, Kristine; Jensen Hansen, Inger Marie

    2016-01-01

    and ComDisDome to cover all relative reports. The following keywords were used: hearing loss, hearing difficulties, hearing disorders, hearing impairment, sensorineural hearing loss, conductive hearing loss, mixed hearing loss, autoimmune hearing loss, drug ototoxicity, drug-induced hearing loss, hearing......BACKGROUND: Rheumatoid arthritis (RA) is a systemic, inflammatory disease that affects 1% of the population. The auditory system may be involved during the course of disease; however the association of RA and hearing impairment has not been clearly defined. OBJECTIVE: The objective of this review...... is to evaluate published clinical reports related to hearing impairment in patients with RA. Furthermore, we discuss possible pathologies and associated factors as well as new treatment modalities. METHOD: A thorough literature search was performed using available databases including Pubmed, Embase, Cochrane...

  16. Is Cognitive Function in Adults with Hearing Impairment Improved by the Use of Hearing Aids?

    OpenAIRE

    Choi, A Young; Shim, Hyun Joon; Lee, Sung Hee; Yoon, Sang Won; Joo, Eun-Jeong

    2011-01-01

    Objectives In the present study, we investigated whether speech-related cognitive function and speech recognition ability under background noise in adults with hearing impairment are improved with the use of hearing aids. Methods Participants were recruited from the ENT Department of Eulji Hospital from September 2008 to July 2009. The study group comprised 18 participants (mean age, 69.5±8.3 years) with sensorineural hearing loss who were fitted with hearing aids, and the control group compr...

  17. A Meta-analysis of prothrombin G20210A polymorphism and its risk for sudden sensorineural hearing loss%凝血酶原基因G20210A多态性与突发性聋发病风险的Meta分析

    Institute of Scientific and Technical Information of China (English)

    刘博; 冯文静; 彭晓霞; 杨剑

    2013-01-01

    目的 采用Meta分析的方法探讨凝血酶原基因G20210A多态性与突发性聋发病风险的相关性.方法 计算机检索PUBMED、EMBASE、Cochrane图书馆(英文)和中国生物医学文献数据库(CBM),查找凝血酶原基因G20210A多态性与突发性聋发病相关的临床研究,对纳入的文献进行严格方法学质量评价,应用Review Manager Version 4.2软件进行统计分析.结果 共有9篇文献纳入研究,累计病例组735例,对照组1230例.方法学质量评价采用三方面8项计分(满分为8星),结果显示纳入的文献总体质量较高,其中2篇为8星,3篇为7星,1篇为6星,1篇为5星,2篇为4星.Meta分析统计结果提示凝血酶原基因G20210A多态性在基因型水平[OR=1.79,95% CI=(1.06,3.01),P=0.03]和等位基因水平[0R=1.77,95% CI=(1.06,2.97),P=0.03]均可能增加突发性聋的发病风险.结论 凝血酶原基因G20210A多态性可能增加突发性聋的发病风险,但仍需大样本的高质量研究进一步证实.%Objective To investigate the correlation between prothrombin G20210A polymorphism and the risk for idiopathic sudden sensorineural hearing loss (ISSNHL) using Meta-analysis methodology.Methods Databases,including PUBMED,EMBASE,Cochrane Library and CBM,were searched to collect the case control studies on the correlation between prothrombin G20210A polymorphism and idiopathic sudden sensorineural hearing loss.Only high quality studies were included.All analysis were conducted with Review Manager Version 4.2 software.Results A total of 9 studies were included,involving 735 cases and 1230 controls.The quality assessment involved 3 parts,8 scores (totally 8 stars).The results showed the included studies were high-quality.Two studies were 8 stars of quality,three studies were 7 stars,one study was 6 stars,one study was 5 stars,and two studies were 4 stars.Meta-analysis showed that the prothrombin G20210A mutation frequencies of the genotypes and alleles showed significant

  18. 后天性感音神经性聋患者听觉中枢磁共振弥散张量成像研究%Diffusion Tensor Imaging Study of Central Auditory Pathway in Patients with Acquired Sensorineural Hearing Loss

    Institute of Scientific and Technical Information of China (English)

    祝康; 何莹; 侯瑾; 闫静; 郑国玺; 许珉; 白芝兰

    2015-01-01

    目的:探讨后天性感音神经性聋(sensorineural hearing loss ,SNHL)及其病程对听觉中枢白质的影响。方法选后天性SNHL患者30例,根据发病时间分为突发性聋组15例和病程2年以上的SNHL组15例;并选择15例同期行M RI检查的听力正常的其它患者为对照组;运用磁共振弥散张量成像(diffusion tensor imaging , DTI)技术观察各组受试者听觉中枢下丘和外侧丘系的弥散相关参数,包括:部分各向异性(factional anisotropy , FA)值、径向弥散(radial diffusivity ,RD)、轴向弥散(axial diffusivity ,AD)及平均弥散(mean diffusivity ,MD)。结果突聋组、病程2年以上的 SNHL 组及对照组双侧下丘 FA 值大小依次为SNHL 组<对照组<突聋组(P<0.05),对照组和突聋组与2年以上SNHL组间差异均有统计学意义(P<0.05);外侧丘系右侧RD值大小依次为突聋组<对照组<SNHL组(P<0.05),右侧MD值大小依次为对照组<突聋组<SNHL组,且两两比较差异均有统计学意义(P<0.05)。三组下丘及外侧丘系AD值差异无统计学意义(均 P>0.05)。结论突聋患者的听觉中枢未发生明显异常的改变,而病程大于2年以上的后天性SNHL患者听觉中枢神经纤维束明显受到破坏,提示感音神经性听觉损失患者的病程长短对听觉传导通路的结构变化有影响。%Objective Magnetic resonance diffusion tensor imaging (DTI) was applied to study the cantral auditong pathway in patients with .Methods A total of 30 cases of acquired hearing loss patients were divided into 2 groups ,group 1 (15 ,sudden deafness) and group 2 (15 ,with duration up to 2 years SNHL group from the time of onset) .A total of 15 cases of normal-hearing patients on MRI examination were selected as the control group for the same period .All subjects received DTI of whole brain .The values of the whole brain DTI were

  19. Analysis of Intratympanic Dexamethasone Injection Treatment for Refractory Sudden Sensorineural Hearing Loss Effect%鼓室内地塞米松注射治疗难治性突发性感音神经性聋的效果分析

    Institute of Scientific and Technical Information of China (English)

    刘秀娇

    2015-01-01

    目的:对难治性突发性感音神经性聋患者采用鼓室内地塞米松注射治疗的临床效果进行观察和分析。方法从我院2012年3月~2015年3月眼耳鼻科门诊收治的难治性突发性感音神经性聋患者中随机抽取26例进行研究,在行常规治疗无效后采用鼓室内地塞米松注射治疗,对患者的治疗方法和听力改善情况进行回顾性分析。结果治疗30天后,进行纯音测听结果为:有4例显效,听阈提高的平均值为48.5分贝;有5例有效,听阈提高的平均值为18.5分贝;有17例无效,本组治疗的总有效率为34.62%。结论采用鼓室内地塞米松注射方法治疗难治性突发性感音神经性聋可以促进药效的充分发挥,减小对患者的创伤,预防不良反应,有利于改善患者的听力状况。%Objective To observe and analyze the clinical effect of dexamethasone injection in the treatment of refractory sudden deafness. Methods 26 cases of refractory of sudden sexy sensorineural deafness patients was chosen for study in otolaryngology clinic in our hospital in March 2012 to March 2015, row refractory to conventional treatment by intratympanic dexamethasone injection in the treatment, the patient's treatment and hearing improvement were retrospectively analyzed. Results After 30 days of treatment, pure tone audiometry results:4 cases were cured, threshold was increased in the average of 48.5 dB, 5 cases were effective, improve the threshold average 18.5 dB, ineffective in 17 cases, the treatment group total efficiency was 34.62%. Conclusion By intratympanic dexamethasone injection in the treatment of refractory sudden sensorineural hearing loss can promote the efifcacy into full play, reduce the patient's trauma, prevention of adverse reactions, is conducive to improve the patient's hearing status.

  20. Sudden hearing loss in children.

    Science.gov (United States)

    Ječmenica, Jovana; Bajec-Opančina, Aleksandra

    2014-08-01

    Sudden sensorineural hearing loss (SSHL) is defined as a unilateral or bilateral sensorineural hearing loss with at least 30 dB decrease in threshold in 3 contiguous test frequencies occurring over 72 hours or less. It is very rare in children. Sudden hearing loss is a symptom that suggests that there is a problem in the inner ear, surrounding structures, or the whole organism. The etiology and development of this disorder are still not fully understood. The literature contains numerous models of the pathogenesis of SSHL, with childhood SSHL having certain peculiarities. In practical terms, the multifactorial nature of SSHL is important in the choice of diagnostic methods and treatment methods. It is important to determine the cause and effect relationship between the underlying disease and hearing loss.

  1. Sensorineural hearing loss in high school teenagers in Mexico City and its relationship with recreational noise Las alteraciones auditivas de escolares adolescentes en la Ciudad de México pueden estar relacionadas al ruido recreativo

    Directory of Open Access Journals (Sweden)

    María del Consuelo Martínez-Wbaldo

    2009-12-01

    Full Text Available The aim of this study was to measure the frequency of hearing loss in a sample of typical public high-school students exposed to recreational noise, and determine associated risk factors. The sample was made up of 214 teenagers from a high-school in Mexico City; subjects were selected randomly per strata. We applied a questionnaire to identify risk factors for hearing loss and performed a battery of audiologic tests consisting of otoscopy, tympanometry, and pure-tone audiometry. The mean age of the sample was 16 ± 1.07 years; 73% were male and 27%, female. Hearing loss was found in 21% of students. The main hearing loss-related risk factor was exposure to recreational noise: frequent attendance at discotheques and pop-music concerts; use of personal stereos; and noise exposure in school workshops. The high frequency of hearing loss in high school students from one Mexico City school (nearly one fifth of the sample was found to be related to noise exposure mainly during recreational activities.El objetivo de este estudio fue medir la frecuencia de alteraciones auditivas en una muestra de escolares de educación media superior expuestos a ruido recreativo y determinar algunos factores de riesgo asociados. La muestra estuvo constituida por 214 adolescentes de una escuela de la Ciudad de México. Los sujetos fueron seleccionados al azar por medio de una computadora. Se aplicaron cuestionarios con el objeto de identificar los factores de riesgo para alteraciones auditivas y se les practicaron diversos estudios audiológicos consistentes en: otoscopía, timpanometría y una audiometría a tonos puros. La edad media de la muestra fue de 16 ± 1,07 años, 73% fueron del sexo masculino y 27% femenino. Se encontraron alteraciones auditivas en 21% de los estudiantes. Los principales factores de riesgo asociados a alteraciones auditivas fueron: exposición al ruido recreativo al asistir a discotecas, conciertos de música popular, el uso de equipos de

  2. Modeling auditory perception of individual hearing-impaired listeners

    DEFF Research Database (Denmark)

    Jepsen, Morten Løve; Dau, Torsten

    showed that, in most cases, the reduced or absent cochlear compression, associated with outer hair-cell loss, quantitatively accounts for broadened auditory filters, while a combination of reduced compression and reduced inner hair-cell function accounts for decreased sensitivity and slower recovery from...... selectivity. Three groups of listeners were considered: (a) normal hearing listeners; (b) listeners with a mild-to-moderate sensorineural hearing loss; and (c) listeners with a severe sensorineural hearing loss. A fixed set of model parameters were derived for each hearing-impaired listener. The simulations...

  3. Refinement of the locus for non-syndromic sensorineural deafness (DFN2)

    Indian Academy of Sciences (India)

    Bin Cui; Haibing Zhang; Yongzhong Lu; Wei Zhong; Gang Pei; Xiangyin Kong; Landian Hu

    2004-04-01

    Non-syndromic X-linked deafness is a rare form of genetic deafness in humans accounting for a small proportion of all hereditary hearing loss. Different clinical forms of non-syndromic X-linked deafness have been described, and most of these have been mapped. Here, we report a Chinese family affected by a congenital profound sensorineural hearing loss. All phenotypes of this family are clinically compatible with non-syndromic sensorineural deafness (DFN2). A maximum two-point Lod score of 2.32 was obtained at marker DXS6797 ( = 0.00). Recombinants define a region of 4.3 cm flanked by markers DXS6799 and GATA172D05. This region overlaps the previously reported DFN2 region by 2.0 cm.

  4. Auditory hair cell defects as potential cause for sensorineural deafness in Wolf-Hirschhorn syndrome

    Directory of Open Access Journals (Sweden)

    Mohi Ahmed

    2015-09-01

    Full Text Available WHSC1 is a histone methyltransferase (HMT that catalyses the addition of methyl groups to lysine 36 on histone 3. In humans, WHSC1 haploinsufficiency is associated with all known cases of Wolf-Hirschhorn syndrome (WHS. The cardinal feature of WHS is a craniofacial dysmorphism, which is accompanied by sensorineural hearing loss in 15% of individuals with WHS. Here, we show that WHSC1-deficient mice display craniofacial defects that overlap with WHS, including cochlea anomalies. Although auditory hair cells are specified normally, their stereocilia hair bundles required for sound perception fail to develop the appropriate morphology. Furthermore, the orientation and cellular organisation of cochlear hair cells and their innervation are defective. These findings identify, for the first time, the likely cause of sensorineural hearing loss in individuals with WHS.

  5. 突发性聋患者耳鸣程度的相关因素分析%Related factor analysis of the degree of tinnitus in sudden sensorineural hearing loss patients

    Institute of Scientific and Technical Information of China (English)

    陈平; 周津徽

    2013-01-01

    Objective: To provide the theory basis for clinical diagnosis, treatment and prognosis of sudden deafness patients, we detected the relative factors of degree of tinnitus of the patients with sudden deafness. Method: Prospective analysis was used to compare degree of tinnitus with sex, ears, age, degree of hearing lose, hearing curve type and curative effect of tinnitus and sudden deafness. Result: Tinnitus was detected in 87. 2% in the 70 patients who with sudden deafness, and the most and least degree of tinnitus patients was the degree 3(32. 9%) and the degree 5 and 6(0). The total effective rate of sudden deafness and tinnitus was 66. 2% and 71. 3%, respectively. The statistical analysis shown the degree of tinnitus was not related to sex. ears, age, degree of hear-ing lose, auditory curve type and curative effect of tinnitus and sudden deafness (P>0. 05). Conclusion: There was a high rate of tinnitus occurrence in sudden deafness patients, and the moderate degree predominated. The curative effect of tinnitus was better than sudden deafness. There was no relationship between the degree of tinnitus and sex, ears, age, degree of hearing lose, auditory curve type and curative effect of tinnitus and sudden deafness.%目的:探讨影响突发性聋患者耳鸣程度的相关因素,为突发性聋患者耳鸣的临床诊治及预后判断提供依据.方法:前瞻性分析比较70例(74耳)突发性聋伴耳鸣患者的耳鸣程度与性别、耳侧、年龄、听力损失程度、听力曲线类型、耳鸣疗效、突发性聋疗效的关系.结果:突发性聋患者耳鸣的发生率为87.2%,其中耳鸣响度为3级者最多(32.9%),5、6级最少(0).突发性聋的总有效率为66.2%,耳鸣的总有效率为74.3%.耳鸣程度与性别、耳侧、年龄、听力损失程度、听力曲线类型、耳鸣疗效、突发性聋疗效的关系均差异无统计学意义(均P>0.05).结论:突发性聋患者的耳鸣发生率较高,耳鸣以中等程度为

  6. Effects of hearing loss on the subcortical representation of speech cues.

    Science.gov (United States)

    Anderson, Samira; Parbery-Clark, Alexandra; White-Schwoch, Travis; Drehobl, Sarah; Kraus, Nina

    2013-05-01

    Individuals with sensorineural hearing loss often report frustration with speech being loud but not clear, especially in background noise. Despite advanced digital technology, hearing aid users may resort to removing their hearing aids in noisy environments due to the perception of excessive loudness. In an animal model, sensorineural hearing loss results in greater auditory nerve coding of the stimulus envelope, leading to a relative deficit of stimulus fine structure. Based on the hypothesis that brainstem encoding of the temporal envelope is greater in humans with sensorineural hearing loss, speech-evoked brainstem responses were recorded in normal hearing and hearing impaired age-matched groups of older adults. In the hearing impaired group, there was a disruption in the balance of envelope-to-fine structure representation compared to that of the normal hearing group. This imbalance may underlie the difficulty experienced by individuals with sensorineural hearing loss when trying to understand speech in background noise. This finding advances the understanding of the effects of sensorineural hearing loss on central auditory processing of speech in humans. Moreover, this finding has clinical potential for developing new amplification or implantation technologies, and in developing new training regimens to address this relative deficit of fine structure representation. PMID:23654406

  7. 高压氧、鼓室内激素对治疗1周无效突发性聋的疗效对比%Effectiveness of hyperbaric oxygen therapy or intratympanic dexamethasone treatment for sudden sensorineural hearing loss which is no respect for one week’s treatment

    Institute of Scientific and Technical Information of China (English)

    杨立; 余文兴; 黄红星; 黄恒; 唐子轩

    2013-01-01

    目的:了解高压氧或鼓室内激素对入院治疗超过1周无效的中度以上突发性聋患者的治疗价值。方法对56例收入院治疗1周无效的中度以上突发性聋患者临床资料进行回顾性分析。经激素、改善微循环、营养神经等药物治疗治疗1周无效的患者,根据患者意愿分为鼓室内激素注射治疗组和高压氧治疗组,继续使用改善微循环、营养神经等药物,对两组的短期预后进行比较。结果经使用高压氧或鼓室内激素治疗1周,高压氧组平均听力改善12.7±18.0dB,鼓室内激素组听力改善13.6±16.5dB,两组间平均听阈改善差异无统计学差异(t=0.2,P>0.05)。高压氧组治疗有效率为45.2%,鼓室内激素组治疗有效率为48.0%,组间疗效差异无统计学意义(μ=0.54,P>0.05)。发病到开始使用时间7~14天、15~30天、30天以上有效率分别为54.5%、26.7%、37%,组间疗效差异有统计学意义(μ=6.52,P<0.05),所有患者均未出现严重并发症。结论高压氧与鼓室内激素对入院治疗超过1周无效的中度以上突发性聋有治疗意义,两种治疗短期疗效无明显差异,可根据具体情况选择治疗方案。%Objective To investigate and analyze the significance of hyperbaric oxygen therapy or intratympanic dexamethasone treatment for sudden sensorineural hearing loss which is no respect for one week’s treatment .Methods We retrospectived 56 patients with sudden sensorineural hearing loss(SSNHL) who pure tone average (PTA )threshold was more than 40 dB and were admitted to the department of Otorhinolarngology-Head and Neck Surgery ,The Suining Central Hospital from January 2010 to January 2013 ,and they were no respected for one week ’ s treatment .All of the patient were trearted with glucocorticoids ,thrombolytic ,and used hyperbaric oxygen therapy or intratympanic dexamethasone as

  8. 糖皮质激素的不同给药途径及时机对重度和极重度突发性聋疗效的影响%Effect of Different Route and Timing of Administration of Glucocorticoid on the Efficacy for Treatment of Severe or Profound Idiopathic Sudden Sensorineural Hearing Loss

    Institute of Scientific and Technical Information of China (English)

    张志坚; 王新春; 廖华; 华清泉

    2011-01-01

    目的 评价糖皮质激素的3种不同给药途径和用药时机对治疗重度和极重度突发性聋疗效的影响.方法 根据糖皮质激素给药途径,将43例(43耳)重度和极重度突聋患者分为口服组(n=19)、静脉给药组(n=14)和鼓室内给药组(n=10),分别采取晨起口服强的松片、静脉滴注和鼓室内注射地塞米松的给药途径,其余治疗均相同;根据发病后接受糖皮质激素治疗的时机,将43例患者分为2周内组(n=37)和2周后组(n=6),比较不同给药途径及时机各组间疗效.结果 鼓室内给药组,静脉给药组和口服组的总有效率分别为70.00%、78.57%和52.63%,显效率分别为60.00%、57.14%和36.84%,3组间的总有效率和显效率差异均无统计学意义(P>0.05).2周内组和2周后组的显效率分别为56.76%和0.00%,总有效率分别为72.97%和16.67%,2周内组的显效率和总有效率均明显高于与2周后组(P<0.05).结论 作为重度极重度突聋患者的初始(一线)治疗,糖皮质激素的不同给药途径(鼓室内给药、静脉滴注和口服)对疗效无影响;开始糖皮质激素治疗的时机与疗效密切相关,越早使用则疗效越好,最好在发病后2周内开始用药.%Objective To evaluate the effect of different route and timing of administration of glucocorticoid on the efficacy for treatment of severe or profound idiopathic sudden sensorineural hearing loss. Methods Forty three patients with severe or profound idiopathic sudden sensorineural hearing loss were retrospectively studied. Patients were divided into 3 groups according to the different route of administion of glucocorticoid: oral steroid group (n=19), intravenous steroid group (n=14) and intratympanic steroid group (n=10). According to the timing of receiving glucocorticoid treatment after the on-set, the patients were divided into 2 groups: within 2 weeks group (n = 37) and after 2 weeks group (n = 6). Results The total efficacy rate

  9. HEARING ASSESSMENT IN CHRONIC RENAL FAILURE PATIENTS UNDERGOING HEMODIALYSIS

    Directory of Open Access Journals (Sweden)

    Arjun Singh

    2014-01-01

    Full Text Available The auditory sensitivity of 63 patient of chronic renal failure on hemodialysis was assessed in order to know the effect of dialysis on hearing threshold. All selected patient were non diabetic with normal tympanic membrane and with no history of ototoxic drug and any hereditary hearing problems. Pure tone audiometry was done before and after dialys is and all cases were followed for 3 month. A high incidence of high frequency sensorineural hearing loss was obtained which could not be attributed to age , noise exposure and ottotoxicity. An association between high frequency sensorineural hearing loss a nd hemodialysis is thus suggested KEYWORDS: Hemodialysis ; Pure tone audiometry ; High frequency sensorineural hearing loss ; Duration of disease ; Chronic renal failure

  10. THIAMINE–RESPONSIVE MEGALOBLASTIC ANEMIA, SENSORINEURAL DEAFNESS AND DIABETES MELLITUS

    Directory of Open Access Journals (Sweden)

    M. Kadivar R. Moradian

    2006-11-01

    Full Text Available Abstract- The syndrome of diabetes mellitus, sensorineural deafness and megaloblastic anemia dose not result from thiamine deficiency. The previous reported patients had no sign of beriberi, had normal nutrition, and had no evidence of malabsorption. The features of this syndrome with apparent inheritance of autosomal recessive trait may define this puzzling syndrome as a true thiamine dependency state. The first Iranian patient was described by Vossough et al. in 1995. We found nine new cases with diagnostic criteria of thiamine responsive megaloblastic anemia during eight years of our study. In two patients, presentation of diabetes and anemia was concomitant. All of them were deaf with sensorineural hearing loss which was detected in infancy up to two years of age. The presence of congenital valvular heart disease was eliminated by normal echocardiography, but cardiomyopathy was discovered in two. Nonspecific amino-aciduria was discovered in three but urinary screening tests for hereditary orotic aciduria were negative. Ox-Phos biochemistry of muscle mitochondria which demonstrates severe defect in complexes I, III, IV in diabetes mellitus associated with deafness, were done but was unremarkable in our patients. Urinary methylmalonic acid and methyl malonyl carnitine by GS/MS and TMS was done in our patients and showed abnormal results in six patients. Thiamine gene, SLC 19A2, was detected in four patients.

  11. [FEDERAL CLINICAL RECOMMENDATIONS IN DIAGNOSIS, TREATMENT AND PREVENTION OF HEARING LOSS DUE TO NOISE].

    Science.gov (United States)

    Adeninskaya, E E; Bukhtiarov, I V; Bushmanov, A Iu; Dayhes, N A; Denisov, E I; Izmerov, N F; Mazitova, N N; Pankova, V B; Preobrazhenskaya, E A; Prokopenko, L V; Simonova, N I; Tavartkiladze, G A; Fedina, I N

    2016-01-01

    Noise induced hearing loss is a slowly developing hearing impairment, caused by occupational exposure to excessive noise levels, constitutes a lesion of the auditory analyzer and clinically manifested as chronic bilateral sensorineural hearing loss. Currently, there is not a treatment that provide a cure of sensorineural hearing loss. Regular, individually tailored treatment should be directed to the pathogenic mechanisms and specific clinical symptoms of hearing loss, as well as the prevention of complications. We recommend using non-drug therapies that can improve blood flow in labyrinth, tissue and cellular metabolism.

  12. 影响突发性聋患者耳鸣疗效的相关因素分析%Analysis of Related Factors on Tinnitus Curative Effect in Sudden Sensorineural Hearing Loss Patients

    Institute of Scientific and Technical Information of China (English)

    陈平; 周津徽

    2013-01-01

    Objective To provide the theoretic basis for clinical diagnosis, treatment and prognosis of sudden deafness patients, we investigated the related factors which might influence treatment effects on tinnitus of sudden deafness patients. Methods A prospective analysis was used to compare the relationship among the treatment effects of tinnitus for 70 patients with sudden deafness, such as genders, ears, ages, degrees of hearing lose, degrees of tinnitus and audiometric configurations. Results Tinnitus was detected in 87. 18% in 70 patients with sudden deaf ness, and the total effective rate of sudden deafness and tinnitus was 66. 22 % and 74. 32 %, respectively. The statis tical analysis has shown that the treatment effects of tinnitus were not related to genders, ears, ages, and degrees of tinnitus (P>0. 05). Comparing the tinnitus patients with various degrees of hearing lose and various audiometric curves, the total therapeutical rate was less in profound deafness and complete deafness patients with tinnitus(P< 0. 01). The total treatment effects of tinnitus in refractory sudden deafness patients was less than the patients who had recovery, remarkable therapeutic effects and therapeutic effects(P<0. 01). Conclusion The treatment effects on tinnitus in sudden deafness patients were more noticeable than that of sudden deafness. The treatment effects of tinnitus were not related to genders, ears, ages, and degrees of tinnitus. It was worse in the patients suffering pro found deafness, complete deafness and refractory sudden deafness.%目的 探讨影响突发性聋患者耳鸣疗效的相关因素,为突发性聋伴耳鸣患者的临床诊治及预后判断提供依据.方法 前瞻性分析比较117例突发性聋患者中符合入组条件的70例(74耳)突发性聋伴耳鸣患者的耳鸣疗效与性别、耳别、年龄、听力损失程度、听力曲线类型、耳鸣严重程度、听力损失疗效的关系.结果 本组117例突发性聋患者中102

  13. 糖皮质激素口服联合鼓室内注射治疗重度和极重度突发性聋%Combined oral and intratympanic glucocorticoids treatment for severe to profound sudden sensorineural hearing loss

    Institute of Scientific and Technical Information of China (English)

    刘璐; 钟时勋

    2015-01-01

    目的观察糖皮质激素全身应用和鼓室内注射联合治疗重度和极重度突发性聋的临床疗效,以探索糖皮质激素治疗突发性聋的方法。方法对54例重度和极重度突发性聋患者的临床资料进行回顾性分析,所有患者均给予口服激素、改善微循环、溶栓抗凝等治疗,同意加用鼓室内注射激素的患者为治疗组,其余患者为对照组,治疗2周后复查纯音测听。结果治疗组和对照组患者平均听阈改善均具有显著统计学意义,但两组之间疗效无差异(P=0.194)。治疗组与对照组中重度突发性聋患者间疗效无差异(P=0.251),两组中极重度突发性聋患者间疗效也无差异(P=0.380)。结论糖皮质激素全身应用联合鼓室内注射治疗重度和极重度突发性聋有效,但并不能得到较单独全身用药更好的疗效。%[ABSTRACT]OBJECTIVETo evaluate the efficacy of combined oral and intratympanic glucocorticoids treatment for severe to profound sudden sensorineural hearing loss(SSNHL).METHODSFifty-four patients with severe to profound SSNHL were retrospectively studied. They were treated with oral steroids, vasodilators, anticoagulants. The patients who accepted intratympanic methylprednisolone sodium succinate were included the therapy group, the others were included in the control group. Hearing improvements were analyzed respectively after two weeks.RESULTSHearing in both groups were improved significantly after treatment(P<0.01), but there was no difference in hearing improvements between two groups(P=0.194). The efficacy for severe SSNHL patients in therapy group was equal to those who were in control group (P=0.251), so was the efficacy for profound SSNHL patients in both groups(P=0.380).CONCLUSIONThe combined systemic and intratympanic glucocorticoids treatment was effective for patients with severe to profound SSNHL, but while with no better efficacy than oral glucocorticoid alone.

  14. Munchausen Syndrome by Proxy: Mother Fabricates Infant's Hearing Impairment.

    Science.gov (United States)

    Kahn, Gerri; Goldman, Ellen

    1991-01-01

    Case study reports a case of Munchausen Syndrome by Proxy, a form of child abuse in which the mother presents a child for treatment for a condition she herself has invented or created. This case study describes the ways in which a mother obtained a diagnosis of sensorineural hearing loss as well as amplification for her normally hearing infant.…

  15. Study on the relationship between GRα、GRβ-isoform of glucocorticoid receptors and glucoeorticoid sensitivity in sudden sensorineural hearing loss%糖皮质激素受体α和β与突发性聋治疗的相关性

    Institute of Scientific and Technical Information of China (English)

    李春林; 罗英; 杨春平; 杨影; 罗璝

    2011-01-01

    目的 探讨糖皮质激素受体α(glucoeoaicoid receptors,GRα)和13(GRβ)在突发性聋(sudden sensorineural hearing loss,SSHL)糖皮质激素抵抗中的分子生物学机制.方法 选择我科住院的SSHL患者83例,根据疗效分为治疗无效组和治疗敏感组,对照组为我科10例鼻中隔偏曲患者.应用逆转录聚合酶链反应法检测治疗无效组、治疗敏感组SSHL患者及对照组外周血单个核细胞GRα、GRβ mRNA的表达水平,以探讨GRα、GRβ与SSHL糖皮质激素抵抗的关系.结果 全部人选对象均有GRαmRNA和GRβmRNA表达,GRαmRNA表达量高于GRβmRNA,但治疗敏感组、治疗无效组和对照组之间GRαmRNA表达量比较,差异无统计学意义(t=1.813,0.184,P均>0.05).3组间GRβmRNA表达量比较,治疗无效组明显高于治疗敏感组和对照组,差异有统计学意义(t=-3.440,3.942,P均0.05).3组间GRα/GRβ值比较治疗无效组明显低于治疗敏感组和对照组,差异有统计学意义(t=-3.326,-3.383,P均<0.05).结论 在突发性聋患者中,GR亚型在外周血单个核细胞中表达量与糖皮质激素疗效密切相关,检测GRα和GRβ表达量及比值可作为预测糖皮质激素治疗反应的重要指标.

  16. 突发性耳聋的椎-基底动脉DSA表现及经椎动脉内灌注前列地尔治疗的初步研究%Digital Subtraction Angiography Abnormalities in 30 Adults with Sudden Sensorineural Hearing Loss and Evaluation of Alprostadil Injection Into the Vertebral Artery

    Institute of Scientific and Technical Information of China (English)

    刘源; 张勤修; 邓晓筑; 周立; 谢慧; 何春水; 廖华强; 刘洋; 张丽峰; 曾伟

    2010-01-01

    目的 分析突发性耳聋(sudden sensorineural hearing loss,SSNHL)患者椎-基底动脉系统DSA的表现特点及经椎动脉灌注前列地尔的疗效.资料与方法 对30例SSNHL患者分别在两侧椎动脉行DSA检查,分析椎动脉、基底动脉、小脑前下动脉(AICA)、内听动脉的影像学表现,然后经导管在椎动脉灌注前列地尔(平均剂量5μg,灌注时间5 min).术后1周复查听力,观察听力改善情况.结果 30例均成功进行上述检查、治疗,无相关并发症出现.30例中,2例出现一侧椎动脉闭塞,5例椎动脉硬化.分别有23.3%(7/30)的右侧AICA和30.0%(9/30)的左侧AICA呈现缺失或细小改变,63.3%(19/30)的右侧内听动脉和73.3%(22/30)的左侧内听动脉呈现缺失或细小改变.术后纯音听阈测试显示听阈水平(500 Hz、1000 Hz、2000 Hz、4000Hz听阈的平均值)平均升高28.2 dBHL,其中痊愈2例,显效8例,有效15例,无效5例,总有效率83.3%.结论 SSNHL与内听动脉、AICA细小、缺失导致的内耳缺血有关,灌注扩张血管的药物能够改善症状,提高听力.

  17. 38 CFR 17.149 - Sensori-neural aids.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Sensori-neural aids. 17... Prosthetic, Sensory, and Rehabilitative Aids § 17.149 Sensori-neural aids. (a) Notwithstanding any other provision of this part, VA will furnish needed sensori-neural aids (i.e., eyeglasses, contact...

  18. MicroRNAs in sensorineural diseases of the ear

    Directory of Open Access Journals (Sweden)

    Kathy eUshakov

    2013-12-01

    Full Text Available Non-coding microRNAs have a fundamental role in gene regulation and expression in almost every multicellular organism. Only discovered in the last decade, microRNAs are already known to play a leading role in many aspects of disease. In the vertebrate inner ear, microRNAs are essential for controlling development and survival of hair cells. Moreover, dysregulation of microRNAs has been implicated in sensorineural hearing impairment, as well as in other ear diseases such as cholesteatomas, vestibular schwannomas and otitis media. Due to the inaccessibility of the ear in humans, animal models have provided the optimal tools to study microRNA expression and function, in particular mice and zebrafish. A major focus of current research has been to discover the targets of the microRNAs expressed in the inner ear, in order to determine the regulatory pathways of the auditory and vestibular systems. The potential for microRNA manipulation in development of therapeutic tools for hearing impairment is as yet unexplored, paving the way for future work in the field.

  19. Current aspects of hearing loss from occupational and leisure noise

    Directory of Open Access Journals (Sweden)

    Plontke, S.

    2004-12-01

    Full Text Available Hearing loss from occupational and leisure noise numbers amongst the most frequent causes of an acquired sensorineural hearing loss. Here we present a review of up-to-date findings on the pathophysiology of acoustic injury to the inner ear, with special attention being paid to its molecular-biological and genetic aspects. Epidemiological aspects shall also be dealt with, as shall the roles of lacking recovery from occupational noise due to additional exposure by leisure noise and the combined exposure of noise and chemicals. Based on the epidemiological and pathophysiological findings and against the background of published animal-experimental, pre-clinical and clinical findings, the various approaches for prevention, protection and therapeutic intervention with acoustic trauma are discussed. Pharmacological strategies involving anti-oxidative, anti-excitotoxic and anti-apoptotic substances as well as non-pharmacological strategies like "sound conditioning" are given attention. Furthermore, systemic and local substance application as well as the therapy of acute acoustic trauma and chronic hearing problems (including modern therapy forms for comorbidities such as tinnitus shall be delved into.

  20. The Hearing Outcomes of Cochlear Implantation in Waardenburg Syndrome

    OpenAIRE

    Koyama, Hajime; Kashio, Akinori; Sakata, Aki; Tsutsumiuchi, Katsuhiro; Matsumoto, Yu; Karino, Shotaro; Kakigi, Akinobu; Iwasaki, Shinichi; Yamasoba, Tatsuya

    2016-01-01

    Objectives. This study aimed to determine the feasibility of cochlear implantation for sensorineural hearing loss in patients with Waardenburg syndrome. Method. A retrospective chart review was performed on patients who underwent cochlear implantation at the University of Tokyo Hospital. Clinical classification, genetic mutation, clinical course, preoperative hearing threshold, high-resolution computed tomography of the temporal bone, and postoperative hearing outcome were assessed. Result. F...

  1. Masker phase effects in normal-hearing and hearing-impaired listeners: evidence for peripheral compression at low signal frequencies

    DEFF Research Database (Denmark)

    Oxenham, Andrew J.; Dau, Torsten

    2004-01-01

    curvature. Results from 12 listeners with sensorineural hearing loss showed reduced masker phase effects, when compared with data from normal-hearing listeners, at both 250- and 1000-Hz signal frequencies. The effects of hearing impairment on phase-related masking differences were not well simulated...... are affected by a common underlying mechanism, presumably related to cochlear outer hair cell function. The results also suggest that normal peripheral compression remains strong even at 250 Hz....

  2. Vici syndrome associated with sensorineural hearing loss and laryngomalacia.

    Science.gov (United States)

    Ozkale, Murat; Erol, Ilknur; Gümüş, Ayten; Ozkale, Yasemin; Alehan, Füsun

    2012-11-01

    The phenotypically heterogeneous, autosomal recessive Vici syndrome was first described in 1988 in a sister and brother with oculocutaneous albinism, agenesis of the corpus callosum, cataract, cardiomyopathy, cleft lip, and immunodeficiency. Only 14 cases of Vici syndrome have yet been reported, several involving morphologic and functional defects in addition to those described in the initial case. We report on a 3-month-old Turkish girl with Vici syndrome associated with laryngomalacia, further expanding the clinical spectrum. We also review clinical features in all 15 Vici syndrome patients, to distinguish general from less common signs. To the best of our knowledge, this report is the first of a Turkish patient with Vici syndrome. PMID:23044023

  3. Auditory hair cell defects as potential cause for sensorineural deafness in Wolf-Hirschhorn syndrome

    OpenAIRE

    Mohi Ahmed; Kiyoe Ura; Andrea Streit

    2015-01-01

    WHSC1 is a histone methyltransferase (HMT) that catalyses the addition of methyl groups to lysine 36 on histone 3. In humans, WHSC1 haploinsufficiency is associated with all known cases of Wolf-Hirschhorn syndrome (WHS). The cardinal feature of WHS is a craniofacial dysmorphism, which is accompanied by sensorineural hearing loss in 15% of individuals with WHS. Here, we show thatWHSC1-deficient mice display craniofacial defects that overlap with WHS, including cochlea anomalies. Although audit...

  4. 高压氧或鼓室内激素对突发性聋的挽救治疗疗效对比%Effectiveness of hyperbaric oxygen therapy or intratympanic dexamethasone treatment for salvage therapy of sudden sensorineural hearing loss

    Institute of Scientific and Technical Information of China (English)

    杨立; 何刚; 唐子轩; 黄红星

    2014-01-01

    目的:了解高压氧或鼓室内激素对入院治疗超过1周无效的中度以上突发性聋患者的治疗价值。方法对56例收入院治疗1周无效的中度以上突发性聋患者临床资料进行回顾性分析。经激素、改善微循环、营养神经等药物治疗治疗1周无效的患者,根据患者意愿分为鼓室内激素注射治疗组和高压氧治疗组,继续使用改善微循环、营养神经等药物,对两组的短期预后进行比较。结果经使用高压氧或鼓室内激素治疗1周,高压氧组平均听力改善12.7±18.0 dB,鼓室内激素组听力改善13.6±16.5 dB,两组间平均听阈改善差异无统计学差异(t=0.2,p>0.05)。高压氧组治疗有效率为45.2%,鼓室内激素组治疗有效率为48.0%,组间疗效差异无统计学意义(μ=0.54,p>0.05)。发病到开始使用时间7~14天、15~30天、30天以上有效率分别为54.5%、26.7%、37%,组间疗效差异有统计学意义(μ=6.52,p0.05). The efficient in groups of hyperbaric oxygen therapy or intratympanic dexamethasone were 45.2 %,48.0 % separately , which were no significantly different in two groups(μ=0.54,p>0.05). The efficient in SSNHL groups which time from onset to treatment were 7~14days,15~30days,more than one month were 54.5%,26.7%,37%, there was a significant statistic difference among three groups(μ=6.52,p<0.05). Al of the patients were no serious complications.Conclusion:Hyperbaric oxygen therapy or intratympanic dexamethasone treatment is effective for sudden sensorineural hearing loss which is no respect for one week’s treatment. The short-term curative effect are no difference in two treatment.

  5. Congenital hereditary endothelial dystrophy with progressive sensorineural deafness (Harboyan syndrome

    Directory of Open Access Journals (Sweden)

    Abramowicz Marc

    2008-10-01

    Full Text Available Abstract Harboyan syndrome is a degenerative corneal disorder defined as congenital hereditary endothelial dystrophy (CHED accompanied by progressive, postlingual sensorineural hearing loss. To date, 24 cases from 11 families of various origin (Asian Indian, South American Indian, Sephardi Jewish, Brazilian Portuguese, Dutch, Gypsy, Moroccan, Dominican have been reported. More than 50% of the reported cases have been associated with parental consanguinity. The ocular manifestations in Harboyan syndrome include diffuse bilateral corneal edema occurring with severe corneal clouding, blurred vision, visual loss and nystagmus. They are apparent at birth or within the neonatal period and are indistinguishable from those characteristic of the autosomal recessive CHED (CHED2. Hearing deficit in Harboyan is slowly progressive and typically found in patients 10–25 years old. There are no reported cases with prelinglual deafness, however, a significant hearing loss in children as young as 4 years old has been detected by audiometry, suggesting that hearing may be affected earlier, even at birth. Harboyan syndrome is caused by mutations in the SLC4A11 gene located at the CHED2 locus on chromosome 20p13-p12, indicating that CHED2 and Harboyan syndrome are allelic disorders. A total of 62 different SLC4A11 mutations have been reported in 98 families (92 CHED2 and 6 Harboyan. All reported cases have been consistent with autosomal recessive transmission. Diagnosis is based on clinical criteria, detailed ophthalmological assessment and audiometry. A molecular confirmation of the clinical diagnosis is feasible. A variety of genetic, metabolic, developmental and acquired diseases presenting with clouding of the cornea should be considered in the differential diagnosis (Peters anomaly, sclerocornea, limbal dermoids, congenital glaucoma. Audiometry must be performed to differentiate Harboyan syndrome from CHED2. Autosomal recessive types of CHED (CHED2 and

  6. Systemic steroid reduces long-term hearing loss in experimental pneumococcal meningitis

    DEFF Research Database (Denmark)

    Worsøe, Lise Lotte; Brandt, C.T.; Lund, S.P.;

    2010-01-01

    Sensorineural hearing loss is a common complication of pneumococcal meningitis. Treatment with corticosteroids reduces inflammatory response and may thereby reduce hearing loss. However, both experimental studies and clinical trials investigating the effect of corticosteroids on hearing loss have...... generated conflicting results. The objective of the present study was to determine whether systemic steroid treatment had an effect on hearing loss and cochlear damage in a rat model of pneumococcal meningitis....

  7. Transdermal electrical stimulation in sensorineural tinnitus

    OpenAIRE

    S Maini; Deoganonkar, S. C.

    1999-01-01

    In 73 patients, comprising of 84 ears, with persistent decompensated tinnitus and sensorineu-ral deafness, tinnitus suppression was attempted with low frequency, low ampere transdermal electrical stimula-tion (TDES). The causes of tinnitus were presbyacusis, unknown aetiology, noise exposure, otosclerosis, ototoxic drugs, endolymphatic hydrops, labyrinthitis and post head injury. Reduction of tinnitus was achieved in 38 of 84 ears. Results i.e. improvement were achieved in patients in the fol...

  8. Viral causes of hearing loss: a review for hearing health professionals.

    Science.gov (United States)

    Cohen, Brandon E; Durstenfeld, Anne; Roehm, Pamela C

    2014-07-29

    A number of viral infections can cause hearing loss. Hearing loss induced by these viruses can be congenital or acquired, unilateral or bilateral. Certain viral infections can directly damage inner ear structures, others can induce inflammatory responses which then cause this damage, and still others can increase susceptibility or bacterial or fungal infection, leading to hearing loss. Typically, virus-induced hearing loss is sensorineural, although conductive and mixed hearing losses can be seen following infection with certain viruses. Occasionally, recovery of hearing after these infections can occur spontaneously. Most importantly, some of these viral infections can be prevented or treated. For many of these viruses, guidelines for their treatment or prevention have recently been revised. In this review, we outline many of the viruses that cause hearing loss, their epidemiology, course, prevention, and treatment.

  9. Genetic mutation susceptibility of hearing loss in child with severe neonatal jaundice

    International Nuclear Information System (INIS)

    This case report demonstrates a case of 5-year-old non-syndromic Malay boy who passed the hearing screening test however he was confirmed has bilateral profound sensorineural hearing loss diagnosed at 3 months of age by brain stem evoked response (BSER). He has background history of severe neonatal jaundice and male siblings of hearing impairment. The antenatal and birth history was uneventful apart from maternal hypothyroidism. His other two elder brothers have bilateral sensorineural hearing loss and history of severe neonatal jaundice as well. The ear examinations, computed tomography scan and magnetic resonance imaging revealed normal findings. Right sided cochlear implantation was done at the age of 3 years old and he is still under audiology follow-up. Conclusion: Genetic studies are important to determine the cause of genetic mutation in susceptibility to hearing impairment that run in his family after severe neonatal jaundice. Those baby with risk of developing hearing loss required diagnostic hearing assessment. (author)

  10. Features of hearing impairment in children with perinatal pathology of the central nervous system

    OpenAIRE

    KHAYDAROVA GAVKHAR SAIDAKHMATOVNA; MATKULIEV HAITBAY MATKULIEVICH; SHAYKHOVA KHALIDA ERKINOVNA

    2016-01-01

    The analysis of hearing loss in 58 children with perinatal CNS. The correlation of peripheral sensorineural disorders and degree of hemodynamic disorders in vertebrate arteries. The results showed a significant increase in the severity of peripheral hearing loss with increasing severity of the ground state from light to heavy.

  11. Hearing loss in Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Pemmaiah K.D

    2011-10-01

    Full Text Available Background: The complex arrangement of inner ear makes it potential target of hyperglycaemic damage. A study was conducted to identify the probable occurrence of hearing loss as a complication of Diabetes Mellitus (DM.Aims and objective:· To assess the hearing loss in type 2 diabetic patients and correlate with age, duration of diabetes, HbA1C.· To correlate hearing loss with nerve conduction study.Design: Cross sectional study was done involving randomly 110 Type 2 DM patients. Data regarding their age and duration of diabetes was collected. Pure tone Audiometry and Nerve conduction study was done. HbA1c level determined. Data statistically analysed using Pearson correlation coefficient.Results: Out of 110 patients 48 patients (43.6% had bilateral Sensorineural hearing in higher frequency (2000hz, 4000hz. Among them Severe hearing loss (71 dB to 90dB was seen in 7 patients (6.36%, moderately severe hearing loss (61dB to 70dB in 16 patients (14.54% and moderate hearing loss(30dB to 60 dB in 25 patients (22.7%. Among 47 patients who had diabetes for more than 10 years, 29 patients (61.7% showed at least mild hearing loss. Duration of DM and sensorineural hearing loss at 2000Hz and 4000Hz showed statistically significant correlation (Pearson coefficient r= 0.561 and r= 0.727 respectively at 0.01 level. In other frequencies no significant correlation was found. Coefficient of determination was r2=0.31(31% and r2=0.52(52% respectively between duration of DM and hearing loss at 2000Hz and 4000Hz. The correlation of hearing loss in lower frequency with HbA1c did not show any statistical significance. However HbA1c and hearing loss in higher frequency (2000 hz and 4000hz showed statistically significant correlation (Pearson coefficient r= 0.282 and r= 0.385 respectively. The correlation of hearing loss with Nerve conduction study did not show any statistical significance.

  12. Current aspects of hearing loss from occupational and leisure noise

    OpenAIRE

    Plontke, S; Zenner, H.-P.

    2004-01-01

    Hearing loss from occupational and leisure noise numbers amongst the most frequent causes of an acquired sensorineural hearing loss. Here we present a review of up-to-date findings on the pathophysiology of acoustic injury to the inner ear, with special attention being paid to its molecular-biological and genetic aspects. Epidemiological aspects shall also be dealt with, as shall the roles of lacking recovery from occupational noise due to additional exposure by leisure noise and the combined...

  13. Benefit of Analog, Programmable and Digital Hearing Aids

    Directory of Open Access Journals (Sweden)

    Jamileh Fatahi

    2006-12-01

    Full Text Available Background and Aims: As the hearing aid technology progressively promotes toward replacing analog hearing aids with digital and programmable ones, comparison of the patient satisfaction of those kinds of hearing aids by means of a valuable tool seems so necessary. So, the aim of this study was to compare self-reported benefit of analog, digitally controlled programmable and digital hearing aids for reducing disability caused by hearing impairment in mild to severe sensorineural hearing impaired persons. Materials and Methods: This cross-sectional study was performed on 90 persons with mild to severe sensorineural hearing loss dividing into three groups: 43 subjects were fitted with digital, 15 with programmable, 32 with analog hearing aids. After pure tone audiometry, Abbreviated profile of hearing aid benefit (APHAB was completed before and one month after using hearing aids to determine the benefit of them. Results: Global APHAB mean scores for digital, programmable and analog hearing aids were 49.05, 33.19 and 39.53, respectively. Ease of Communication subscale mean scores were 53.46 for digitals, 37.66 for programmables and 39.09 for analogs. Background noise subscale mean scores for digital programmable and analog hearing aids were 46.36, 25.53 and 35.31, respectively. Global and also both subscale mean scores showed significant difference between digital hearing aids and programmable and analog ones. There was no significant difference between reverberation subscale mean scores of three groups. Conclusion: It seems digital hearing aids may be more beneficial to reduce disability caused by hearing loss than analog and programmable hearing aids are.

  14. Acute cortical deafness in a child with MELAS syndrome.

    Science.gov (United States)

    Pittet, Marie P; Idan, Roni B; Kern, Ilse; Guinand, Nils; Van, Hélène Cao; Toso, Seema; Fluss, Joël

    2016-05-01

    Auditory impairment in mitochondrial disorders are usually due to peripheral sensorineural dysfunction. Central deafness is only rarely reported. We report here an 11-year-old boy with MELAS syndrome who presented with subacute deafness after waking up from sleep. Peripheral hearing loss was rapidly excluded. A brain MRI documented bilateral stroke-like lesions predominantly affecting the superior temporal lobe, including the primary auditory cortex, confirming the central nature of deafness. Slow recovery was observed in the following weeks. This case serves to illustrate the numerous challenges caused by MELAS and the unusual occurrence of acute cortical deafness, that to our knowledge has not be described so far in a child in this setting.

  15. Frequency of mitochondrial 12S rRNA gene A1555G and 961 insC mutations among children with sensorineural deafness in China

    Institute of Scientific and Technical Information of China (English)

    Xia Xu; Guangqian Xing; Qinjun Wei; Zhibin Chen; Hongbo Cheng; Xin Cao; Xingkuan Bu

    2006-01-01

    Objective: To investigate the frequency of mitochondrial 12S rRNA gene A1555G and 961 insC mutations among Chinese with sensorineural deafness. Methods: Blood samples from 78 sporadic cases with sensorineural deafness were obtained and DNA was extracted from the leukocytes, then the mitochondrial DNA target fragments were amplified by polymerase chain reaction(PCR). The 1555G mutations were detected by BsmA I restriction endonuclease digestion, every fragment was analyzed by sequencing; All the 961 insC mutation were detected by direct sequencing. Results: The percent age of A1555G mutation and mt961C insertion were 6.4% and 2.6% in the hearing-impaired Chinese subjects respectively. Conclusion: A1555G and 96linsC mutations in mitochondrial DNA 12S rRNA gene regions may play a role in the pathogenesis of hearing loss in the sporadic cases.

  16. HEARING LOSS IN CHRONIC RENAL FAILURE - AN ASSESSMENT OF MULTIPLE AETIOLOGICAL FACTORS

    OpenAIRE

    Suja Sreedharan; Vishnu Prasad; Jayashree Bhatt; Mahesh Chandra Hegde; Salil Agarwal; Cherukattil Waheeda

    2015-01-01

    Introduction: Sensorineural hearing loss in chronic renal failure is believed to be of multifactorial etiology. Associated hypertension and diabetes mellitus, use of ototoxic drugs, hemodialysis and the changes in metabolic parameters are the various reasons quoted for the hearing loss. Objectives: Our study attempts to correlate the hearing thresholds with the multiple parameters like blood levels of urea, serum creatinine, sodium, potassium, calcium and hemoglobin values incriminated in...

  17. Elderly With Different Types of Hearing Loss and Comorbidities: Satisfaction With Hearing Aids

    Directory of Open Access Journals (Sweden)

    Dashti

    2015-07-01

    Full Text Available Background Hearing loss is developing when age is rising. Initiation and progression rates of hearing loss vary among different individuals and groups. Objectives The current study aimed to determine satisfaction of the elderly with their hearing aids in different types of hearing loss and comorbidities. Patients and Methods The study was conducted on 40 elderly subjects suffering from hearing loss and using hearing aids. The data collection method included assessment of hearing loss in addition to using a questionnaire to estimate respondents' satisfaction with their hearing aids in daily life. The Persian version of the Satisfaction with Amplification in Daily Life (SADL questionnaire was administered. The data were analyzed using descriptive and inferential statistics by SPSS software version19. Results The mean satisfaction scores of the elderly were 4.83 ± 0.51 and 5.36 ± 0.30 in the sensorineural loss groups. There was no significant difference between different comorbidities. There was a significant difference between satisfaction level of cost and services subscales in the symmetrical styles of hearing loss (P value = 0.04. Conclusions The findings of the study indicated a high satisfaction of the elderly with their hearing aids, considering the type of hearing loss. Despite all the efforts to improve the audiologic services during verification process, the elderly should be consulted specifically in order to fit their hearing aid as well as their expectations from aid.

  18. Impact of Early Intervention on Expressive and Receptive Language Development among Young Children with Permanent Hearing Loss

    Science.gov (United States)

    Meinzen-Derr, Jareen; Wiley, Susan; Choo, Daniel I.

    2011-01-01

    Along with early detection, early intervention (EI) is critical for children identified with hearing loss. Evidence indicates that many children with sensorineural hearing loss experience improved language abilities if EI services were initiated at an "early" age. The present study's objectives were to determine the impact of a state EI program on…

  19. Baha solutions for patients with severe mixed hearing loss.

    Science.gov (United States)

    Flynn, Mark C; Sadeghi, Andre; Halvarsson, Glenn

    2009-01-01

    Patients with a mixed hearing loss present special challenges. The amplification demands of mixed hearing loss can drive powerful digital hearing aids to their limits and introduce distortion through saturation. Conversely, the Baha System effectively bypasses the conductive component and focuses on compensating for the sensorineural component of the hearing loss. Ten patients with a mixed hearing loss participated in the present study. Results indicate that Baha provided significant benefits (p < 0.01) over conventional air conduction hearing instruments across the dimensions of audibility, speech understanding and sound quality. Given the increased output force of the latest Baha instruments, once the conductive component of a severe mixed hearing loss becomes greater than 30 dB, a Baha should be considered and evaluated on audiological grounds alone to provide optimal amplification. PMID:19195004

  20. Hearing aid-related satisfaction based on type and degree of hearing loss in elderly

    Directory of Open Access Journals (Sweden)

    Farzad FarajiKhiavi

    2015-02-01

    Full Text Available Background and Aim: Hearing loss is one of the most prevalent chronic diseases in the elderly; using a hearing aid to alleviate auditory impairment can positively affect their quality of life. This research aimed to determine the level of satisfaction concerning hearing aids in elderly people with hearing impairment based on the type and degree of hearing loss.Methods: An analytic cross-sectional research design was used ; the sample included 40 elderly people who used hearing aids. According to the World Health Organization (WHO age classification, participants were divided into two age groups: 65-74 years (n=20 and 75-90 years (n=20. Satisfaction levels were assessed using a standard satisfaction with amplification in daily life (SADL questionnaire.Results: Satisfaction levels in the 65-74 age group were significantly higher than that in the 75-90 age group (p=0.02. Participants with mixed hearing loss revealed higher satisfaction levels than participants with sensorineural hearing loss (p=0.02. On the negative effects dimension, participants with severe hearing loss exhibited significantly higher satisfaction levels than participants with moderate or moderate to severe hearing loss (p=0.01.Conclusion: Total satisfaction mean scores were relatively high in the elderly participants . Negative features could be reduced via careful consultation regarding the aids’ amplifying capabilities and limitations in groups with moderate or moderate to severe hearing loss.

  1. A study on hearing evaluation in patients of chronic renal failure

    Directory of Open Access Journals (Sweden)

    Ravinder Sharma

    2011-01-01

    Full Text Available Aims and Objective: The aim of the study was to evaluate hearing threshold and the severity of hearing loss at different frequencies (250Hz, 500Hz, 1000Hz, 2000Hz, 3000Hz, 4000Hz, 6000Hz, and 8000Hz in patients of chronic renal failure (CRF, and to analyze the role of duration of disease on hearing threshold in patients of CRF. Materials and Methods: Fifty two patients of CRF were evaluated in Nephrology unit and ENT OPD. Cases with middle ear involvement were not included in the study. Pure tone audiometry was done in all cases to establish hearing threshold at different frequencies. Cases with hearing loss were classified according to the severity of hearing loss. In patients with sensorineural hearing loss, mean hearing threshold was calculated. Cases were classified in two groups on the basis of duration of disease (less than two years and more than two years and the mean hearing thresholds were calculated. The significant differences between the mean hearing thresholds of these two groups were assessed using student′s t test for unequal samples. Results : A total of 52 patients (28 males and 24 females were included in the study. Majority of the patients were in 21 to 40 year age group (mean age 36.84 years. Of the 104 ears, 76 ears (73.07% had sensorineural hearing loss and 28 ears (26.93% had normal hearing. Majority of the ears with hearing loss had mild (44.73% or moderate (42.11% sensorineural hearing loss. Mean hearing threshold was higher at low frequencies and high frequencies with a relative sparing of mid frequencies. Comparison of the mean hearing threshold in patients of Group I (duration of disease less than two years - 42 ears and Group II (duration of disease more than two years - 34 ears showed a statistically significant difference (P<0.05 in mean hearing threshold at 250 Hz. Conclusion: Hearing loss is present in majority of the patients of CRF. Most of the cases have mild to moderate sensorineural hearing loss. Hearing

  2. Age- and Gender-Related Mean Hearing Threshold in a Highly-Screened Population: The Korean National Health and Nutrition Examination Survey 2010–2012

    OpenAIRE

    Park, Yun Hwi; Shin, Seung-Ho; Byun, Sung Wan; Kim, Ju Yeon

    2016-01-01

    Background In evaluating hearing disability in medicolegal work, the apportionment of age- and gender-related sensorineural hearing loss should be considered as a prior factor, especially for the elderly. However, in the literature written in the English language no studies have reported on the age- and gender-related mean hearing threshold for the South Korean population. Objective This study aimed to identify the mean hearing thresholds in the South Korean population to establish reference ...

  3. Progressive hearing loss following acquired cytomegalovirus infection in an immunocompromised child.

    Science.gov (United States)

    Kato, Ken; Otake, Hironao; Tagaya, Mitsuhiko; Takahashi, Yoshiyuki; Ito, Yoshinori; Hama, Asahito; Muramatsu, Hideki; Kojima, Seiji; Naganawa, Shinji; Nakashima, Tsutomu

    2013-01-01

    We report a rare case of progressive hearing loss after acquired CMV infection in a child with Langerhans cell histiocytosis (LCH). A 5-month-old female was diagnosed as having LCH. When she was 14 months old, she received an unrelated donor umbilical cord blood transfusion for the treatment of intractable LCH. CMV infection was confirmed after the blood transfusion. Because her own umbilical cord had no CMV, the CMV infection was not congenital. When she was 7 years old, mixed hearing loss was noted with bilateral otitis media with effusion. After that time, the sensorineural hearing loss progressed to bilateral profound hearing loss over 3 years. Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging with gadolinium contrast enhancement revealed a high intensity area in the inner ear that suggested bilateral labyrinthitis. This case demonstrates the possibility that, under the immunodeficiency, the acquired CMV infection causes progressive sensorineural hearing loss.

  4. Hearing loss and cochlear damage in experimental pneumococcal meningitis, with special reference to the role of neutrophil granulytes

    DEFF Research Database (Denmark)

    Brandt, CT; Caye-Thomsen, P; Lund, SP;

    2006-01-01

    Hearing loss is a well-known sequelae from meningitis, affecting up to 25% of survivors. However, the principal components of the infectious and inflammatory reaction responsible for the sensorineural hearing loss remain to be identified. The present study aimed to investigate the impact...... of an augmented neutrophil response on the development of hearing loss and cochlear damage in a model of experimental pneumococcal meningitis in rats. Hearing loss and cochlear damage were assessed by distortion product oto-acoustic emissions (DPOAE), auditory brainstem response (ABR) and histopathology in rats...... infection. Pretreatment with G-CSF increased hearing loss 24 h after infection and on day 8 compared to untreated rats (Mann-Whitney, P = 0.012 and P = 0.013 respectively). The increased sensorineural hearing loss at day 8 was associated with significantly decreased spiral ganglion cell counts (P = 0...

  5. Therapeutic effect of locally injection of bone-marrow mesenchymal stem cells decorated by recombinant vector of lentivirus with IL-4 gene into inner ear on immune-mediated immune sensorineural hearing loss in guinea pigs%慢病毒载体介导IL-4基因修饰BMSCs内耳局部应用治疗免疫性感音神经性聋的实验研究

    Institute of Scientific and Technical Information of China (English)

    郭浪; 谭长强; 崔毓桂; 李王伟

    2011-01-01

    明显减轻免疫性感音 神经性聋动物的内耳免疫炎症反应和听觉功能损伤,前者作用更为显著.从而提示BMSCs(包括经IL-4基因修饰的BMSCs)局部应用可对免疫性内耳病的免疫炎症损伤产生一定的调节和治疗作用,并有向病变部位迁移、聚集的倾向.%Objective: To evaluate the therapeutic effect of local implanting with bone-marrow mesenchymal stem cells ( BMSCs) decorated with recombinant lentivirus vocters carrying interleukin-4 ( IL-4) gene into inner ear, on guinea pigs with immune-mediated sensorineural hearing loss ( IMSNHL) . Methods : Guinea pigs were immunized with keyhole limpet hemocyanin ( KLH) and 33 animal models were established, which were divided into three groups on refering to matched-pairs design. Recombinant lentiviral vector integrated IL-4 gene to infect the BMSCs in vitro, the green fluorescence report and the result of RT-PCR to confirm the successful infection of BMSCs. BMSCs decorated with interleukin-4 ( IL-4) gene ( group A) and without gene ( group B) were implanted separately into scala tymani. Group C as control group were injected phosphate buffer ( PBS) . Auditory functions and the KLH level of Guinea pigs' blood were monitored respectively by auditor brain stem response (ABR) and ELISA test;Fluorography immunohistochemistry test was performed for tracing BMSCs and enzyme immunohistochemistry test for the situation of IL-4 gene express and productive protein distribution in inner ear. HE stain and light microscopy were carried out. Results: There were no significant differences in levels of KLH in blood serum 2 weeks after immunization (pretransplantation) and 1 week after the transplantation of the BMSCs in the same guinea pigs from each group. The threshold of ABR Ⅲ wave decreased in group A and group B, the result was more significant in group A and group B than that in group C ( P < 0. 05 ) . The results of immunohistochemistry test showed that fluorescence positive BMSCs mainly

  6. The Hearing Outcomes of Cochlear Implantation in Waardenburg Syndrome

    Directory of Open Access Journals (Sweden)

    Hajime Koyama

    2016-01-01

    Full Text Available Objectives. This study aimed to determine the feasibility of cochlear implantation for sensorineural hearing loss in patients with Waardenburg syndrome. Method. A retrospective chart review was performed on patients who underwent cochlear implantation at the University of Tokyo Hospital. Clinical classification, genetic mutation, clinical course, preoperative hearing threshold, high-resolution computed tomography of the temporal bone, and postoperative hearing outcome were assessed. Result. Five children with Waardenburg syndrome underwent cochlear implantation. The average age at implantation was 2 years 11 months (ranging from 1 year 9 months to 6 years 3 months. Four patients had congenital profound hearing loss and one patient had progressive hearing loss. Two patients had an inner ear malformation of cochlear incomplete partition type 2. No surgical complication or difficulty was seen in any patient. All patients showed good hearing outcome postoperatively. Conclusion. Cochlear implantation could be a good treatment option for Waardenburg syndrome.

  7. The Hearing Outcomes of Cochlear Implantation in Waardenburg Syndrome.

    Science.gov (United States)

    Koyama, Hajime; Kashio, Akinori; Sakata, Aki; Tsutsumiuchi, Katsuhiro; Matsumoto, Yu; Karino, Shotaro; Kakigi, Akinobu; Iwasaki, Shinichi; Yamasoba, Tatsuya

    2016-01-01

    Objectives. This study aimed to determine the feasibility of cochlear implantation for sensorineural hearing loss in patients with Waardenburg syndrome. Method. A retrospective chart review was performed on patients who underwent cochlear implantation at the University of Tokyo Hospital. Clinical classification, genetic mutation, clinical course, preoperative hearing threshold, high-resolution computed tomography of the temporal bone, and postoperative hearing outcome were assessed. Result. Five children with Waardenburg syndrome underwent cochlear implantation. The average age at implantation was 2 years 11 months (ranging from 1 year 9 months to 6 years 3 months). Four patients had congenital profound hearing loss and one patient had progressive hearing loss. Two patients had an inner ear malformation of cochlear incomplete partition type 2. No surgical complication or difficulty was seen in any patient. All patients showed good hearing outcome postoperatively. Conclusion. Cochlear implantation could be a good treatment option for Waardenburg syndrome. PMID:27376080

  8. [Multicenter trial for sudden hearing loss therapy - planning and concept].

    Science.gov (United States)

    Plontke, S K; Girndt, M; Meisner, C; Probst, R; Oerlecke, I; Richter, M; Steighardt, J; Dreier, G; Weber, A; Baumann, I; Plößl, S; Löhler, J; Laszig, R; Werner, J A; Rahne, T

    2016-04-01

    Systemic steroids are widely used worldwide as a standard of care for primary therapy of idiopathic sudden sensorineural hearing loss (ISSHL). The German ISSHL guideline recommends high-dose steroids for primary therapy of ISSHL, without evidence from randomized controlled trials (RCTs). The rationale for the treatment of ISSHL using high dose steroids is only based on retrospective cohort studies.This article describes the planning and initiation of a multicenter, national, randomized, controlled clinical trial entitled Efficacy and safety of high dose glucocorticosteroid treatment for idiopathic sudden sensorineural hearing loss - a three-armed, randomized, triple-blind, multicenter trial (HODOKORT). This clinical trial aims to compare standard dose with two types of high-dose steroids for primary systemic therapy with respect to their efficacy in improving hearing, and thus communication ability, in patients with idiopathic sudden sensorineural hearing loss.This study is funded by the "Clinical Trials with High Patient Relevance" research program in the health research framework of the German Federal Ministry of Education and Research. It is one of two studies by the German Study Center of Clinical Trials of the German Society of Otorhinolaryngology, Head and Neck Surgery (DSZ-HNO). Planning and initiation was done in cooperation with the DSZ-HNO, the Coordination Center of Clinical Trials of the Martin-Luther-University Halle-Wittenberg, and the Study Center of the University Hospital Freiburg.

  9. Effects of hearing loss on the voice in children.

    Science.gov (United States)

    Bolfan-Stosic, Natalija; Simunjak, Boris

    2007-04-01

    The object of this paper is to report on preliminary acoustic characteristics obtained from a group of 10 to 12 year old males from special institution from Zagreb with more than mild sensorineural hearing losses. The study was structured as an investigation of voice and resonance characteristics of Croatian children with and without sensorineural hearing loss, using sustained phonation of the vowel /a/ which was recorded using a high-quality tape recorder carried out by two voice clinicians. The samples were digitized and analyzed for frequency and spectral characteristics by EZVoice and Bruel & Kjaer Real-time Frequency Analyzer and high quality sound level meter (mouth-to-microphone distance = 30 cm). Differences were observed in perturbation measures; F0 variability; vocal intensity. Spectral deviations were also observed. Discussion focuses on application of these findings by Croatian speech and hearing specialists with the hearing impaired population. Results indicated the following: measures of jitter were significantly elevated in the hearing loss group as compared to the normal controls. A similar result was observed for measures of shimmer. Lack of voice professional's awareness of importance for making pleasant voice quality of hearing-impaired individuals was the initial idea of this study. Patients with hearing losses have been reported to show a wide variety of voice disturbances.

  10. Hearing loss among patients with Turner's syndrome: literature review

    Directory of Open Access Journals (Sweden)

    Cresio Alves

    2014-06-01

    Full Text Available INTRODUCTION: Turner's syndrome (TS is caused by a partial or total deletion of an X chromosome, occurring in 1:2,000 to 1:5,000 live born females. Hearing loss is one of its major clinical manifestations. However, there are few studies investigating this problem. OBJECTIVES: To review the current knowledge regarding the epidemiology, etiology, clinical manifestations and diagnosis of hearing impairment in patients with TS. METHODS: A bibliographic search was performed in the Medline and Lilacs databanks (1980-2012 to identify the main papers associating Turner's syndrome, hearing impairment and its clinical outcomes. CONCLUSIONS: Recurrent otitis media, dysfunction of the Eustachian tube, conductive hearing loss during infancy and sensorineural hearing loss in adolescence are the audiologic disorders more common in ST. The karyotype appears to be important in the hearing loss, with studies demonstrating an increased prevalence in patients with monosomy 45,X or isochromosome 46,i(Xq. Morphologic studies of the cochlea are necessary to help out in the clarifying the etiology of the sensorineural hearing loss.

  11. Experiences of adult patients hearing loss postlingually with Cochlear Implant

    Directory of Open Access Journals (Sweden)

    Teresa María Lizcano Tejado

    2013-09-01

    Full Text Available Hearing loss is a significant public health problem. The incidence is difficult to establish because of the lack of data in people under age three, but is estimated about 1 per thousand for severe and profound hearing loss.A cochlear implant (CI is a device that converts sounds into electrical energy that triggers a sensation of hearing. The IC is indicated in patients with severe bilateral sensorineural hearing loss with null or poor benefit use of hearing aids.The general objective of this project is to understand the experiences of adult patients with severe-profound sensorineural hearing loss with IC postlingually throughout the implementation process.A personal vision of those implemented will allow us to learn how to face the possibility to hear and interact with their environment, applying this information to improve health care provided to them and identifying those areas where such assistance should be improved. Also allow us to compare the initial expectations and have been achieved, creating realistic expectations for future candidates.For its development we have designed a qualitative study, based on the principles and procedures of grounded theory, semistructured interviews, participant observation and discussion groups.The data will be analyzed using the software Nudist ViVo 9.

  12. Hearing Aids

    Science.gov (United States)

    ... more in both quiet and noisy situations. Hearing aids help people who have hearing loss from damage ... your doctor. There are different kinds of hearing aids. They differ by size, their placement on or ...

  13. Formal auditory training in adult hearing aid users

    Directory of Open Access Journals (Sweden)

    Daniela Gil

    2010-01-01

    Full Text Available INTRODUCTION: Individuals with sensorineural hearing loss are often able to regain some lost auditory function with the help of hearing aids. However, hearing aids are not able to overcome auditory distortions such as impaired frequency resolution and speech understanding in noisy environments. The coexistence of peripheral hearing loss and a central auditory deficit may contribute to patient dissatisfaction with amplification, even when audiological tests indicate nearly normal hearing thresholds. OBJECTIVE: This study was designed to validate the effects of a formal auditory training program in adult hearing aid users with mild to moderate sensorineural hearing loss. METHODS: Fourteen bilateral hearing aid users were divided into two groups: seven who received auditory training and seven who did not. The training program was designed to improve auditory closure, figure-to-ground for verbal and nonverbal sounds and temporal processing (frequency and duration of sounds. Pre- and post-training evaluations included measuring electrophysiological and behavioral auditory processing and administration of the Abbreviated Profile of Hearing Aid Benefit (APHAB self-report scale. RESULTS: The post-training evaluation of the experimental group demonstrated a statistically significant reduction in P3 latency, improved performance in some of the behavioral auditory processing tests and higher hearing aid benefit in noisy situations (p-value < 0,05. No changes were noted for the control group (p-value <0,05. CONCLUSION: The results demonstrated that auditory training in adult hearing aid users can lead to a reduction in P3 latency, improvements in sound localization, memory for nonverbal sounds in sequence, auditory closure, figure-to-ground for verbal sounds and greater benefits in reverberant and noisy environments.

  14. No evidence for the diagnostic value of Borrelia serology in patients with sudden hearing loss.

    NARCIS (Netherlands)

    Bakker, R.; Aarts, M.C.; Heijden, G.J. van der; Rovers, M.M.

    2012-01-01

    In this evidence-based case report, we address the following clinical question: What is the predictive value of serological testing for Borrelia for diagnosing neuroborreliosis in patients with sudden sensorineural hearing loss? We searched for relevant articles in PubMed, Embase, and Web of Science

  15. Two sisters with mental retardation, cataract, ataxia, progressive hearing loss, and polyneuropathy.

    OpenAIRE

    Begeer, J H; Scholte, F A; van Essen, A J

    1991-01-01

    Two sisters are described with a disorder characterised by mental retardation, congenital cataract, progressive spinocerebellar ataxia, sensorineural deafness, and signs of peripheral neuropathy. Progressive hearing loss, ataxia, and polyneuropathy became evident in the third decade. The differential diagnosis of this syndrome is discussed including the syndromes described by Berman et al and Koletzko et al.

  16. The effect of cochlear implantation on tinnitus in patients with bilateral hearing loss : A systematic review

    NARCIS (Netherlands)

    Ramakers, Geerte G J; van Zon, Alice; Stegeman, Inge; Grolman, Wilko

    2015-01-01

    OBJECTIVES: To present an overview of the effect of cochlear implantation on tinnitus in adults with bilateral sensorineural hearing loss. DATA SOURCES: PubMed, Cochrane Library, CINAHL, and Embase databases were searched for articles from database inception up to January 13, 2015. METHODS: A system

  17. Recurrent Bacterial Meningitis in a Child with Hearing Impairment, Mondini Dysplasia: A Case Report

    Directory of Open Access Journals (Sweden)

    Narges Mazloomi Nobandegani

    2012-12-01

    Full Text Available Recurrent bacterial meningitis is not a common disease and makes physicians seek underlying predisposing factors which can result from anatomic anomalies or immunodeficiency. In this paper we present a boy with recurrent bacterial meningitis with the history of trauma and sensorineural hearing loss. Mondini dysplasia was demonstrated with computed homographic scans (CT-Scan of temporal bones.

  18. Congenital stapes malformation: Rare conductive hearing loss in a patient with Waardenburg syndrome.

    Science.gov (United States)

    Melzer, Jonathan M; Eliason, Michael; Conley, George S

    2016-04-01

    Waardenburg syndrome is a known autosomal dominant cause of congenital hearing loss. It is characterized by a distinctive phenotypic appearance and often involves sensorineural hearing loss. Temporal bone abnormalities and inner ear dysmorphisms have been described in association with the disease. However, middle ear abnormalities as causes of conductive hearing loss are not typically seen in Waardenburg syndrome. We discuss a case of an 8-year-old female who meets diagnostic criteria for Waardenburg syndrome type 3 and who presented with a bilateral conductive hearing loss associated with congenital stapes fixation. We discuss management strategy in this previously unreported phenotype. PMID:26152551

  19. Prevalence, heritability and genetic correlations of congenital sensorineural deafness and pigmentation phenotypes in the Border Collie.

    Science.gov (United States)

    De Risio, Luisa; Lewis, Tom; Freeman, Julia; de Stefani, Alberta; Matiasek, Lara; Blott, Sarah

    2011-06-01

    The objectives of this study were to estimate prevalence, heritability and genetic correlations of congenital sensorineural deafness (CSD) and pigmentation phenotypes in the Border Collie. Entire litters of Border Collies that presented to the Animal Health Trust (1994-2008) for assessment of hearing status by brain stem auditory evoked response (BAER) at 4-10 weeks of age were included. Heritability and genetic correlations were estimated using residual maximum likelihood (REML). Of 4143 puppies that met the inclusion criteria, 97.6% had normal hearing status, 2.0% were unilaterally deaf and 0.4% were bilaterally deaf. Heritability of deafness as a trichotomous trait (normal/unilaterally deaf/bilaterally deaf) was estimated at 0.42 using multivariate analysis. Genetic correlations of deafness with iris colour and merle coat colour were 0.58 and 0.26, respectively. These results indicate that there is a significant genetic effect on CSD in Border Collies and that some of the genes determining deafness also influence pigmentation phenotypes. PMID:20570536

  20. Hearing Loss Alters Serotonergic Modulation of Intrinsic Excitability in Auditory Cortex

    OpenAIRE

    Rao, Deepti; Basura, Gregory J.; Roche, Joseph; Daniels, Scott; Mancilla, Jaime G.; Manis, Paul B.

    2010-01-01

    Sensorineural hearing loss during early childhood alters auditory cortical evoked potentials in humans and profoundly changes auditory processing in hearing-impaired animals. Multiple mechanisms underlie the early postnatal establishment of cortical circuits, but one important set of developmental mechanisms relies on the neuromodulator serotonin (5-hydroxytryptamine [5-HT]). On the other hand, early sensory activity may also regulate the establishment of adultlike 5-HT receptor expression an...

  1. Prophylactic and therapeutic functions of T-type calcium blockers against noise-induced hearing loss

    OpenAIRE

    Shen, Haiyan; Zhang, BaoPing; Shin, June-Ho; Lei, Debin; Du, Yafei; Gao, Xiang; Wang, Qiuju; Ohlemiller, Kevin K.; Piccirillo, Jay; Bao, Jianxin

    2006-01-01

    Cochlear noise injury is the second most frequent cause of sensorineural hearing loss, after aging. Because calcium dysregulation is a widely recognized contributor to noise injury, we examined the potential of calcium channel blockers to reduce noise-induced hearing loss (NIHL) in mice. We focused on two T-type calcium blockers, trimethadione and ethosuximide, which are anti-epileptics approved by the Food and Drug Administration. Young C57BL/6 mice of either gender were divided into three g...

  2. Occupational hearing loss of market mill workers in the city of Accra, Ghana

    Directory of Open Access Journals (Sweden)

    Emmanuel D Kitcher

    2014-01-01

    Full Text Available Noise induced hearing loss (NIHL is an irreversible sensorineural hearing loss associated with exposure to high levels of excessive noise. Prevention measures are not well established in developing countries. This comparative cross sectional study aims to determine the prevalence of hearing loss in both a group of high risk workers and a control group and to assess their knowledge of the effects of noise on hearing health. A total of 101 market mill workers and 103 controls employed within markets in the city of Accra, Ghana, were evaluated using a structured questionnaire and pure tone audiometry. The questionnaire assessed factors including self-reported hearing loss, tinnitus, knowledge on the effects of noise on hearing health and the use of hearing protective devices. Pure tone audiometric testing was conducted for both mill workers and controls. Noise levels at the work premises of the mill workers and controls were measured. Symptoms of hearing loss were reported by 24 (23.76% and 8 (7.7% mill workers and controls respectively. Fifty-five (54.5% and fifty-four (52.37% mill workers and controls exhibited knowledge of the effects of noise on hearing health. Five (5.0% mill workers used hearing protective devices. There was significant sensorineural hearing loss and the presence of a 4 kHz audiometric notch among mill workers when compared with controls for the mean thresholds of 2 kHz, 3 kHz and 4 kHz (P = 0. 001. The prevalence of hearing loss in the better hearing ears of the mill workers and controls was 24.8% and 4.8% respectively (P < 0.5. The prevalence of hearing loss, which may be characteristic of NIHL in the better hearing ears of the mill workers and controls was 24.8% and 4.8% respectively. The majority of mill workers did not use hearing protection.

  3. Neuromagnetic index of hemispheric asymmetry prognosticating the outcome of sudden hearing loss.

    Directory of Open Access Journals (Sweden)

    Lieber Po-Hung Li

    Full Text Available The longitudinal relationship between central plastic changes and clinical presentations of peripheral hearing impairment remains unknown. Previously, we reported a unique plastic pattern of "healthy-side dominance" in acute unilateral idiopathic sudden sensorineural hearing loss (ISSNHL. This study aimed to explore whether such hemispheric asymmetry bears any prognostic relevance to ISSNHL along the disease course. Using magnetoencephalography (MEG, inter-hemispheric differences in peak dipole amplitude and latency of N100m to monaural tones were evaluated in 21 controls and 21 ISSNHL patients at two stages: initial and fixed stage (1 month later. Dynamics/Prognostication of hemispheric asymmetry were assessed by the interplay between hearing level/hearing gain and ipsilateral/contralateral ratio (I/C of N100m latency and amplitude. Healthy-side dominance of N100m amplitude was observed in ISSNHL initially. The pattern changed with disease process. There is a strong correlation between the hearing level at the fixed stage and initial I/C(amplitude on affected-ear stimulation in ISSNHL. The optimal cut-off value with the best prognostication effect for the hearing improvement at the fixed stage was an initial I/C(latency on affected-ear stimulation of 1.34 (between subgroups of complete and partial recovery and an initial I/C(latency on healthy-ear stimulation of 0.76 (between subgroups of partial and no recovery, respectively. This study suggested that a dynamic process of central auditory plasticity can be induced by peripheral lesions. The hemispheric asymmetry at the initial stage bears an excellent prognostic potential for the treatment outcomes and hearing level at the fixed stage in ISSNHL. Our study demonstrated that such brain signature of central auditory plasticity in terms of both N100m latency and amplitude at defined time can serve as a prognostication predictor for ISSNHL. Further studies are needed to explore the long

  4. ‘Ecstasy’ Enhances Noise-Induced Hearing Loss

    OpenAIRE

    Church, Michael W.; Zhang, Jinsheng S.; Langford, Megan M.; Perrine, Shane A.

    2013-01-01

    ‘Ecstasy’ or 3,4-methylenedioxy-N-methamphetamine (MDMA) is an amphetamine abused for its euphoric, empathogenic, hallucinatory, and stimulant effects. It is also used to treat certain psychiatric disorders. Common settings for Ecstasy use are nightclubs and “rave” parties where participants consume MDMA and dance to loud music. One concern with the club setting is that exposure to loud sounds can cause permanent sensorineural hearing loss. Another concern is that consumption of MDMA may enha...

  5. Cochlear implantation: a biomechanical prosthesis for hearing loss.

    Science.gov (United States)

    Yawn, Robert; Hunter, Jacob B; Sweeney, Alex D; Bennett, Marc L

    2015-01-01

    Cochlear implants are a medical prosthesis used to treat sensorineural deafness, and one of the greatest advances in modern medicine. The following article is an overview of cochlear implant technology. The history of cochlear implantation and the development of modern implant technology will be discussed, as well as current surgical techniques. Research regarding expansion of candidacy, hearing preservation cochlear implantation, and implantation for unilateral deafness are described. Lastly, innovative technology is discussed, including the hybrid cochlear implant and the totally implantable cochlear implant.

  6. Hearing Impairment

    Science.gov (United States)

    ... hearing loss is present at birth. Acquired hearing loss happens later in life — during childhood, the teen years, or in adulthood — ... for your ears to avoid a permanent hearing loss. See your doctor right away ... basis. What's Life Like for People Who Are Hearing Impaired? For ...

  7. Hearing Screening

    Science.gov (United States)

    Johnson-Curiskis, Nanette

    2012-01-01

    Hearing levels are threatened by modern life--headsets for music, rock concerts, traffic noises, etc. It is crucial we know our hearing levels so that we can draw attention to potential problems. This exercise requires that students receive a hearing screening for their benefit as well as for making the connection of hearing to listening.

  8. Hearing impairment in Stickler syndrome: a systematic review

    Directory of Open Access Journals (Sweden)

    Acke Frederic R E

    2012-10-01

    Full Text Available Abstract Background Stickler syndrome is a connective tissue disorder characterized by ocular, skeletal, orofacial and auditory defects. It is caused by mutations in different collagen genes, namely COL2A1, COL11A1 and COL11A2 (autosomal dominant inheritance, and COL9A1 and COL9A2 (autosomal recessive inheritance. The auditory phenotype in Stickler syndrome is inconsistently reported. Therefore we performed a systematic review of the literature to give an up-to-date overview of hearing loss in Stickler syndrome, and correlated it with the genotype. Methods English-language literature was reviewed through searches of PubMed and Web of Science, in order to find relevant articles describing auditory features in Stickler patients, along with genotype. Prevalences of hearing loss are calculated and correlated with the different affected genes and type of mutation. Results 313 patients (102 families individually described in 46 articles were included. Hearing loss was found in 62.9%, mostly mild to moderate when reported. Hearing impairment was predominantly sensorineural (67.8%. Conductive (14.1% and mixed (18.1% hearing loss was primarily found in young patients or patients with a palatal defect. Overall, mutations in COL11A1 (82.5% and COL11A2 (94.1% seem to be more frequently associated with hearing impairment than mutations in COL2A1 (52.2%. Conclusions Hearing impairment in patients with Stickler syndrome is common. Sensorineural hearing loss predominates, but also conductive hearing loss, especially in children and patients with a palatal defect, may occur. The distinct disease-causing collagen genes are associated with a different prevalence of hearing impairment, but still large phenotypic variation exists. Regular auditory follow-up is strongly advised, particularly because many Stickler patients are visually impaired.

  9. Transducer Type and Design Influence on the Hearing Loss Compensation Behaviour of the Electromagnetic Middle Ear Implant in a Finite Element Analysis

    OpenAIRE

    Liu, Houguang; Ge, Shirong; Cheng, Gang; Yang, Jianhua; Rao, Zhushi; Huang, Xinsheng

    2014-01-01

    Several types of electromagnetic transducer for the middle ear implants (MEIs) have been developed as an alternative to conventional hearing aids for the rehabilitation of sensorineural hearing loss. Electromagnetic transducer type and design are thought to have a significant influence on their hearing compensation performance. To investigate these effects, a middle ear computational model was constructed based on a complete set of microcomputerized tomography section images of a human ear. I...

  10. Validity of hearing impairment calculation methods for prediction of self-reported hearing handicap

    Directory of Open Access Journals (Sweden)

    Andrew B John

    2012-01-01

    Full Text Available Worker′s compensation for hearing loss caused by occupational noise exposure is calculated by varying methods, from state to state within the United States (US, with many employing arithmetic formulas based on the pure-tone audiogram, to quantify hearing loss. Several assumptions unsupported or weakly supported by empirical data underlie these formulas. The present study evaluated the ability of various arithmetic hearing impairment calculations to predict a self-reported hearing handicap in a sample of presenting with sensorineural hearing loss. 204 adults (127 male, 77 female ranging in age from 18 to 94 served as participants. The sample was selected to exclude patients who had been referred for hearing testing for a medicolegal examination or a hearing conservation appointment. A hearing handicap was measured by the Hearing Handicap Inventory for Adults/for the Elderly (HHIA/E. The covariance analysis of linear structural equations was used to assess the relative strength of correlation with the HHIA/E score among the six formulas and various forms of pure-tone average. The results revealed that all the hearing impairment calculations examined were significantly, but weakly, correlated with the self-reported hearing impairment scores. No significant differences among the predictive abilities of the impairment calculations were evident; however, the average binaural impairment assigned differed significantly among the six calculations examined. Individuals who demonstrated 0% impairment had significantly lower (i.e., better HHIA/E scores compared to those with non-zero impairment for each formula. These results supported the idea that audiometric data provided an insufficient explanation for real-world hearing difficulties.

  11. The effect of symmetrical and asymmetrical hearing impairment on music quality perception.

    Science.gov (United States)

    Cai, Yuexin; Zhao, Fei; Chen, Yuebo; Liang, Maojin; Chen, Ling; Yang, Haidi; Xiong, Hao; Zhang, Xueyuan; Zheng, Yiqing

    2016-09-01

    The purpose of this study was to investigate the effect of symmetrical, asymmetrical and unilateral hearing impairment on music quality perception. Six validated music pieces in the categories of classical music, folk music and pop music were used to assess music quality in terms of its 'pleasantness', 'naturalness', 'fullness', 'roughness' and 'sharpness'. 58 participants with sensorineural hearing loss [20 with unilateral hearing loss (UHL), 20 with bilateral symmetrical hearing loss (BSHL) and 18 with bilateral asymmetrical hearing loss (BAHL)] and 29 normal hearing (NH) subjects participated in the present study. Hearing impaired (HI) participants had greater difficulty in overall music quality perception than NH participants. Participants with BSHL rated music pleasantness and naturalness to be higher than participants with BAHL. Moreover, the hearing thresholds of the better ears from BSHL and BAHL participants as well as the hearing thresholds of the worse ears from BSHL participants were negatively correlated to the pleasantness and naturalness perception. HI participants rated the familiar music pieces higher than unfamiliar music pieces in the three music categories. Music quality perception in participants with hearing impairment appeared to be affected by symmetry of hearing loss, degree of hearing loss and music familiarity when they were assessed using the music quality rating test (MQRT). This indicates that binaural symmetrical hearing is important to achieve a high level of music quality perception in HI listeners. This emphasizes the importance of provision of bilateral hearing assistive devices for people with asymmetrical hearing impairment. PMID:26611684

  12. Hearing Loss in Patients with Shunt-Treated Hydrocephalus.

    Science.gov (United States)

    Panova, Margarita V; Geneva, Ina E; Madjarova, Kalina I; Bosheva, Miroslava N

    2015-01-01

    Hearing loss is a common manifestation of the long-term complications in patients with shunt treated hydrocephalus along with motor development disturbance, cognitive and visual impairment, epilepsy and endocrine disorders. The aim of the present study was to investigate the alterations of hearing in patients with shunt treated hydrocephalus of non-tumor etiology and at least one year after implantation of ventriculo-peritoneal shunt, as well as their impact on the quality of life of patients. The study included 70 patients (age range 1.25 years - 21.25 years) with shunted non-tumor hydrocephalus and at least one year after placement of the shunt system. Hearing alterations were proved by measuring the brainstem auditory evoked potentials (BAEP) for children up to 5 years of age and children with mental retardation; audiograms was used for children older than 5 years with normal neuro-psychological development (NPD). Of the 70 studied patients 17 (24%) had hearing loss (10 bilateral and 7-unilateral) and all of them had sensorineural hearing loss, which is associated with low weight at birth, posthemorrhagic hydrocephalus and brainstem symptoms at the time of diagnosis of hydrocephalus. Hearing pathology was found more often in shunt-treated patients with NPD retardation, poor functional status and low quality of life. Children with shunt-treated hydrocephalus have hearing loss of sensorineural type. Children with brain stem symptomatology at diagnosing hydrocephalus and children with post-hemorrhagic hydrocephalus show higher risk of hearing loss. Children with shunted hydrocephalus and hearing loss show lower NPD, lower quality of life and lower functional status.

  13. 耳鸣治疗仪联合银杏蜜环口服液对突发性耳聋伴耳鸣的疗效观察%Clinical observation on treatment of sudden sensorineural hearing loss with tinnitus with Ginkgo mihuan oral liquid combined with Tinnitus-curing instrument

    Institute of Scientific and Technical Information of China (English)

    赵颖; 张勋

    2016-01-01

    Objective:To observe the clinical treatment effect of Ginkgo mihuan oral liquid combined with tinnitus-curing instrument on the patients with sudden deafness associated with tinnitus.Methods: One hundred and twenty patients with sudden deafness associated with tinnitus were randomly divided into treatment group and control group one and control group two. Treatment group were treated with Ginkgo mihuan oral liquid combined with Tinnitus-curing instrument. The patients in control group were given Ginkgo mihuan oral liquid, the other control group used tinnitus-curing instrument. Observe the tinnitus and hearing improved progress.Results: In treatment group, the effective rate of tinnitus improvement was higher than that in control group, the differences were statistically significant(x2=7.040,x2=5.952;P<0.05), but the effective rate of hearing improvement was not higher than that in control group, the differences was not statistically significant(x2=0.621,x2=2.813;P<0.05).Conclusion: Ginkgo mihuan oral liquid combined with Tinnitus-curing instrument has certain curative effect on tinnitus recovery of patients with sudden hearing loss.%目的:观察银杏蜜环口服液配合耳鸣治疗仪在突发性耳聋伴耳鸣治疗中的临床疗效。方法:选取120例突发性耳聋伴耳鸣患者,按照随机数表法将其分为治疗组、对照1组及对照2组,每组40例。治疗组口服银杏蜜环口服液同时应用耳鸣治疗仪,对照1组采用单纯口服银杏蜜环口服液,对照2组采用单纯应用耳鸣治疗仪,观察3组耳鸣及听力改善情况。结果:经综合治疗后,均不同程度残留有耳鸣,耳鸣治疗总有效率为82.5%,耳鸣恢复两两比较,治疗组均高于对照组,差异有统计学意义(x2=7.040,x2=5.952;P<0.05);听力恢复总有效率为27.5%,两两比较差异均无统计学意义(x2=0.621,x2=2.813,x2=0.827;P>0.05)。结论:耳鸣治疗仪配合银杏蜜环口服

  14. EFFECT OF EARLY ONSET TYPE 2 DIABETES MELLITUS ON HEARING

    Directory of Open Access Journals (Sweden)

    Veena Pani

    2013-11-01

    Full Text Available ABSTRACT: INTRODUCTION: Diabetes mellitus is a multifunctional metabolic disorder affecting almost all the systems of the body. There is a strong relation between diabetes mellitus and hearing. The three main theories of pathogenesis of hearing impairment in diabetics are micro angiopathy, .neuropathy and combination of both. Even though studies have proved the occurrence of sensorineural hearing loss (SNHL in diabetes mellitus (DM , disagreement still exists among some about their relation. DESIGN : prospective design. AIM: Present study aimed 1 To find the prevalence of Sensorineural Hearing Loss in Type 2 Diabetes Mellitus 2 To study the association of hearing loss with the foll owing factors among type 2 DM (a Duration of Diabetes Mellitus (b Severity of hyperglycemia. 3 To evaluate the result of our study and to compare our data with similarly published studies. METHOD : 75 individuals (150 ears who have type 2 Diabetes Melli tus participated in the study. RESULTS : Prevalence of SNHL in type 2 DM was 80%. There was no association between SNHL and duration of DM but positive association was found between SNHL and severity of hyperglycemia. DISCUSSION: Globalization is rapidly tr ansforming India from a developing to a developed country. People have become more health conscious and they expect to add more socially and economically productive years to their life span and hence this disorder which manifests mainly in middle age and o lder years of life require consideration. Hence this study is the need of the hour.

  15. [Recovery of hearing: results of delayed medical treatment in patients with idiopathic sudden hearing loss].

    Science.gov (United States)

    Maassen, M M; Pfister, M; Plontke, S; Koitschev, A; Vögler, A; Löwenheim, H

    2002-12-01

    For the treatment of idiopathic sudden sensorineural hearing loss (ISSNHL), a variety of studies about intravenous drug administration with the beginning of treatment in the early period of less then one week after the onset of hearing loss have been performed. In contrast, very little information is available about the efficacy of intravenous drug therapy for ISSNHL with the beginning of treatment later than four weeks after the onset of hearing loss. In a retrospective chart review we studied the treatment results of 57 patients with ISSNHL with beginning of treatment later than four weeks after the onset of hearing loss with no spontaneous recovery of hearing. Patients received a treatment with intravenous administration of Dextran (concentration 40 g/l with NaCl 0.9%) and Procain-HCl (a derivative of the local anaesthetic lidocaine,400-800 mg in a 500 ml rheologic infusion of Dextran 40). 25% of the patients showed a significant improvement of 10 dB or more in hearing threshold at 1000 Hz measured in bone-conducted pure tone audiometry. In a subjective evaluation 53% of the patients noticed a subjective improvement of their individual hearing thresholds. PMID:12474128

  16. Cortical Electrophysiological Markers of Language Abilities in Children with Hearing Aids: A Pilot Study

    Directory of Open Access Journals (Sweden)

    David Bakhos

    2014-01-01

    Full Text Available Objective. To investigate cortical auditory evoked potentials (CAEPs in pediatric hearing aid (HA users, with and without language impairment. Design. CAEPs were measured in 11 pediatric HA users (age: 8–12 years with moderate bilateral sensorineural hearing loss (HL; participants were classified according to language ability. CAEPs were also measured for a control group of 11 age-matched, normal-hearing (NH children. Results. HL children without language impairment exhibited normal CAEPs. HL children with language impairment exhibited atypical temporal CAEPs, characterized by the absence of N1c; frontocentral responses displayed normal age-related patterns. Conclusion. Results suggest that abnormal temporal brain function may underlie language impairment in pediatric HA users with moderate sensorineural HL.

  17. Mutation analysis of SLC26A4 for Pendred syndrome and nonsyndromic hearing loss by high-resolution melting

    DEFF Research Database (Denmark)

    Chen, Neng; Tranebjærg, Lisbeth; Rendtorff, Nanna Dahl;

    2011-01-01

    Pendred syndrome and DFNB4 (autosomal recessive nonsyndromic congenital deafness, locus 4) are associated with autosomal recessive congenital sensorineural hearing loss and mutations in the SLC26A4 gene. Extensive allelic heterogeneity, however, necessitates analysis of all exons and splice sites...

  18. Hearing loss in low-birth-weight infants.

    Science.gov (United States)

    Anagnostakis, D; Petmezakis, J; Papazissis, G; Messaritakis, J; Matsaniotis, N

    1982-07-01

    The hearing of 98 perinatal intensive care survivors with a mean birth weight of 1,540 g was assessed at a mean age of 6 1/2 years. They represented 73% of the long-term survivors with birth weights of 1,800 g or less who had been cared for in our neonatal unit during the three-year period 1971 through 1973. Nine of the 98 infants had sensorineural hearing loss, and 14 had exudative otitis media. During their neonatal period, the infants with hearing loss experienced more frequent apneic attacks, hyperbilirubinemia (serum bilirubin level, greater than 14 mg/dL), and hypothermia compared with their healthy counterparts. There was no evidence that the duration of stay in the incubator or the use of stay in the incubator or the use of ototoxic drugs had affected the hearing of these low-birth-weight infants.

  19. Permanent Sensorineural Deafness in a Patient with Chronic Myelogenous Leukemia Secondary to Intracranial Hemorrhage

    Directory of Open Access Journals (Sweden)

    Sakshi Kapur

    2013-01-01

    Full Text Available A 52-year-old male presented with tinnitus and fullness in left ear for one day. Workup revealed a white blood cell count of 685×103/μL with marked increase in granulocyte series and myeloid precursors on peripheral smear. The initial impression was chronic myelogenous leukemia with hyperleukocytosis, and patient was started on hydration, hydroxyurea, and allopurinol. Patient tolerated bone marrow biopsy well but continued to bleed excessively from the biopsy site. Results confirmed Philadelphia chromosome positive chronic myelogenous leukemia (chronic phase. On day three of hospitalization, patient developed sudden slurred speech along with shaking movements involving extremities. Magnetic resonance imaging revealed multiple hemorrhages throughout the brain. Hydroxyurea was continued until insurance coverage for nilotinib was getting approved. On day nine of hospitalization, patient developed sudden bilateral sensorineural deafness. Repeat magnetic resonance imaging revealed multiple new hemorrhages throughout the brain. Computer tomography of the temporal bones showed inflammatory changes in right and left mastoid cells. Nilotinib was started on day eleven of hospitalization. Patient’s white blood cell count continued to decrease, but there was no improvement in hearing. Four months later, patient was treated with bilateral transmastoid cochlear implants. This case highlights permanent deafness as a hemorrhagic complication secondary to chronic myelogenous leukemia.

  20. Is Sudden Hearing Loss Associated with Atherosclerosis?

    Directory of Open Access Journals (Sweden)

    Mohsen Rajati

    2016-05-01

    Full Text Available Introduction: Sudden sensorineural hearing-loss (SSNHL patients constitute approximately 2–3% of referrals to ear, nose and throat (ENT clinics. Several predisposing factors have been proposed for this condition; one of which is vascular disorders and perfusion compromise. In this research the atherosclerotic changes and their known risk factors are studied in SSNHL patients.   Materials and Methods: Thirty SSNHL patients and 30 controls were evaluated with regard to cardiovascular risks including history, heart examination, blood pressure, body mass index, waist circumference, electrocardiogram, blood sugar, triglycerides, cholesterol, high-sensitivity C-reactive protein (HSCRP; also, carotid artery color Doppler study was undertaken to measure intima media thickness(IMT.   Results: IMT and HSCRP showed an increased risk in the case group compared with the controls (P= 0.005 & P=0.001. However, waist circumference, history of smoking, fasting blood sugar, lipid profile, and electrocardiogram revealed no significant difference between the two groups. Interestingly, blood pressure and body mass index were higher in the controls in this study.   Conclusion:  Sudden sensorineural hearing loss may be associated with subclinical atherosclerosis.

  1. Is Sudden Hearing Loss Associated with Atherosclerosis?

    Science.gov (United States)

    Rajati, Mohsen; Azarpajooh, Mahmoud Reza; Mouhebati, Mohsen; Nasrollahi, Mostafa; Salehi, Maryam; Khadivi, Ehsan; Nourizadeh, Navid; Hashemi, Firoozeh; Bakhshaee, Mehdi

    2016-01-01

    Introduction: Sudden sensorineural hearing-loss (SSNHL) patients constitute approximately 2–3% of referrals to ear, nose and throat (ENT) clinics. Several predisposing factors have been proposed for this condition; one of which is vascular disorders and perfusion compromise. In this research the atherosclerotic changes and their known risk factors are studied in SSNHL patients. Materials and Methods: Thirty SSNHL patients and 30 controls were evaluated with regard to cardiovascular risks including history, heart examination, blood pressure, body mass index, waist circumference, electrocardiogram, blood sugar, triglycerides, cholesterol, high-sensitivity C-reactive protein (HSCRP); also, carotid artery color Doppler study was undertaken to measure intima media thickness(IMT). Results: IMT and HSCRP showed an increased risk in the case group compared with the controls (P= 0.005 & P=0.001). However, waist circumference, history of smoking, fasting blood sugar, lipid profile, and electrocardiogram revealed no significant difference between the two groups. Interestingly, blood pressure and body mass index were higher in the controls in this study. Conclusion: Sudden sensorineural hearing loss may be associated with subclinical atherosclerosis. PMID:27429947

  2. [Phenotypic trends and breeding values for canine congenital sensorineural deafness in Dalmatian dogs].

    Science.gov (United States)

    Blum, Meike; Distl, Ottmar

    2014-01-01

    In the present study, breeding values for canine congenital sensorineural deafness, the presence of blue eyes and patches have been predicted using multivariate animal models to test the reliability of the breeding values for planned matings. The dataset consisted of 6669 German Dalmatian dogs born between 1988 and 2009. Data were provided by the Dalmatian kennel clubs which are members of the German Association for Dog Breeding and Husbandry (VDH). The hearing status for all dogs was evaluated using brainstem auditory evoked potentials. The reliability using the prediction error variance of breeding values and the realized reliability of the prediction of the phenotype of future progeny born in each one year between 2006 and 2009 were used as parameters to evaluate the goodness of prediction through breeding values. All animals from the previous birth years were used for prediction of the breeding values of the progeny in each of the up-coming birth years. The breeding values based on pedigree records achieved an average reliability of 0.19 for the future 1951 progeny. The predictive accuracy (R2) for the hearing status of single future progeny was at 1.3%. Combining breeding values for littermates increased the predictive accuracy to 3.5%. Corresponding values for maternal and paternal half-sib groups were at 3.2 and 7.3%. The use of breeding values for planned matings increases the phenotypic selection response over mass selection. The breeding values of sires may be used for planned matings because reliabilities and predictive accuracies for future paternal progeny groups were highest.

  3. Pengaruh Hemodialisis Terhadap Kejadian Kurang Pendengaran Sensorineural Pada Penderita Gagal Ginjal Kronik

    Directory of Open Access Journals (Sweden)

    Loriana Ulfa

    2016-06-01

    Full Text Available Sensorineural hearing loss (SNHL can occur in patients with chronic renal failure (CRF who receive hemodialysis (HD. SNHL is caused by hemodialysis occured in any frequency. The factors affect the disease include, among others, age, hypertension, and diabetes mellitus (DM. The effect of hemodialysis onSNHL occurrence in patients with CRF was analyzed in this study. It was a cohort study on 52 patients with CRF who met the inclusion criteria. The sample consists of two groups, 26 patients with CRF who received hemodialysis and 26 patients with CRF who did not received hemodialysis. Timpanoaudiometry was performed on HD group (patient with HD before the first HD and after the third HD. Timpanoaudiometry was performed on HD group (patient without HD at the same time with the first group. The data on age, hypertension, and DM were obtained from medical records. The results were analyzed with Chi-Square test. It was found that 30.7% SNHL patients were in the HD group consisting of 26.9% mild degree patients and 3.8% moderate degree patients . Mean of hearing threshold decrease was 8.13 ± 5.30. There was no patient with SNHL in the non-HD group. Analysis with Chi-Square test showed that hemodialysis affects SNHL occurrence (p=0.004. Age (p=0.084, hypertension (p=0.215, and DM (p=0.683 do not affect SNHL occurrence. It is concluded that hemodialysis affects SNHL occurrence whileage, hypertension, and DM do not. [MKB. 2016;48(2:98–104

  4. GJB2 (Cx26) gene mutations in Chinese patients with congenital sensorineural deafness and a report of one novel mutation

    Institute of Scientific and Technical Information of China (English)

    肖自安; 谢鼎华

    2004-01-01

    Background Mutations in GJB2 gene are a major cause of autosomal recessive congenital hearing loss and the cause in some rare cases of the autosomal dominant form. The purpose of This study was to investigate the frequency and the features of GJB2 mutations in the Chinese patients with congenital sensorineural deafness. Methods Using PCR amplifying the entire coding region of GJB2 gene and direct DNA sequencing to analyze mutations in this gene among unrelated 69 cases with autosomal recessive congenital nonsyndromic deafness and 27 cases of dominant congenital deafness and 35 sporadic cases. We also detected mutations in GJB2 in 100 control subjects with normal hearing.Results 17.4% (12/69) of the probands in the autosomal recessive, 7.4% (2/27) of dominant families and 5.7% (2/35) of the sporadic congenital deafness patients had deafness-causing mutations in GJB2, respectively. Nine types of the mutations in GJB2 were detected in the recessive and sporadic group. They consisted of five types of polymorphism, and four types of deafness-causing mutation with homozygous 35delG in 1 sporadic (1/35), and 235delC frameshift mutation in 1 sporadic (homozygotes) and 10 recessive patients (2 heterozygotes and 8 homozygotes), and homozygous 442G→A missense mutation and homozygous 465T→A nonsense mutation in 1 different recessive proband, respectively. The 465T→A that related to recessive deafness was a novel mutation found by this study. The homozygous (10/69, 14.5%) and the heterozygous (2/69, 2.9%) GJB2 mutation in the recessive patients (12/69, 17.4%) and the homozygotes in the sporadic patient (2/35, 5.7%) all had congenital severe to profound sensorineural hearing loss. 511G→A missense mutation and 299-300delAT frameshift mutation were found in two autosomal dominant congenital deafness families (2/27, 7.4%). The total mutation frequency of GJB2 was 12.2% (16/131) in the Chinese patients with congenital sensorineural deafness and 235delC was the most common

  5. Vowel perception by noise masked normal-hearing young adults

    Science.gov (United States)

    Richie, Carolyn; Kewley-Port, Diane; Coughlin, Maureen

    2005-08-01

    This study examined vowel perception by young normal-hearing (YNH) adults, in various listening conditions designed to simulate mild-to-moderate sloping sensorineural hearing loss. YNH listeners were individually age- and gender-matched to young hearing-impaired (YHI) listeners tested in a previous study [Richie et al., J. Acoust. Soc. Am. 114, 2923-2933 (2003)]. YNH listeners were tested in three conditions designed to create equal audibility with the YHI listeners; a low signal level with and without a simulated hearing loss, and a high signal level with a simulated hearing loss. Listeners discriminated changes in synthetic vowel tokens /smcapi e ɛ invv æ/ when F1 or F2 varied in frequency. Comparison of YNH with YHI results failed to reveal significant differences between groups in terms of performance on vowel discrimination, in conditions of similar audibility by using both noise masking to elevate the hearing thresholds of the YNH and applying frequency-specific gain to the YHI listeners. Further, analysis of learning curves suggests that while the YHI listeners completed an average of 46% more test blocks than YNH listeners, the YHI achieved a level of discrimination similar to that of the YNH within the same number of blocks. Apparently, when age and gender are closely matched between young hearing-impaired and normal-hearing adults, performance on vowel tasks may be explained by audibility alone.

  6. Advances in the Understanding of the Genetic Causes of Hearing Loss in Children Inform a Rational Approach to Evaluation.

    Science.gov (United States)

    Carey, John C; Palumbos, Janice C

    2016-10-01

    Hearing loss represents the most common sensory disability of children. Remarkable advances in the identification of genes underlying nonsyndromic and syndromic hearing loss in just the last 2 decades have led to the ability to determine the specific genetic cause of hearing loss in many children. Surprisingly one gene, GJB2, encoding the protein connexin-26, accounts for about 20 % of sensorineural hearing loss (including in India) and is considered the first tier test in evaluating an infant with unexplained congenital hearing loss. Using the knowledge of the etiology of hearing loss, the authors propose a diagnostic reasoning process for the assessment of a child in the pediatric setting. Second tier testing consists of the multiple gene panels using whole exome sequencing strategies, and is becoming available in some regions of the world including the US. Referral to medical genetics is always a consideration in a child with no explanation for the hearing loss and in families with questions about recurrence risk.

  7. Types of Hearing Aids

    Science.gov (United States)

    ... Devices Consumer Products Hearing Aids Types of Hearing Aids Share Tweet Linkedin Pin it More sharing options ... some features for hearing aids? What are hearing aids? Hearing aids are sound-amplifying devices designed to ...

  8. Hearing Assistive Technology

    Science.gov (United States)

    ... for the Public / Hearing and Balance Hearing Assistive Technology Hearing Assistive Technology: FM Systems | Infrared Systems | Induction ... Assistive Technology Systems Solutions What are hearing assistive technology systems (HATS)? Hearing assistive technology systems (HATS) are ...

  9. The development and standardization of Self-assessment for Hearing Screening of the Elderly

    Science.gov (United States)

    Kim, Gibbeum; Na, Wondo; Kim, Gungu; Han, Woojae; Kim, Jinsook

    2016-01-01

    Purpose The present study aimed to develop and standardize a screening tool for elderly people who wish to check for themselves their level of hearing loss. Methods The Self-assessment for Hearing Screening of the Elderly (SHSE) consisted of 20 questions based on the characteristics of presbycusis using a five-point scale: seven questions covered general issues related to sensorineural hearing loss, seven covered hearing difficulty under distracting listening conditions, two covered hearing difficulty with fast-rated speech, and four covered the working memory function during communication. To standardize SHSE, 83 elderly participants took part in the study: 25 with normal hearing, and 22, 23, and 13 with mild, moderate, and moderate-to-severe sensorineural hearing loss, respectively, according to their hearing sensitivity. All were retested 3 weeks later using the same questionnaire to confirm its reliability. In addition, validity was assessed using various hearing tests such as a sentence test with background noise, a time-compressed speech test, and a digit span test. Results SHSE and its subcategories showed good internal consistency. SHSE and its subcategories demonstrated high test–retest reliability. A high correlation was observed between the total scores and pure-tone thresholds, which indicated gradually increased SHSE scores of 42.24%, 55.27%, 66.61%, and 78.15% for normal hearing, mild, moderate, and moderate-to-severe groups, respectively. With regard to construct validity, SHSE showed a high negative correlation with speech perception scores in noise and a moderate negative correlation with scores of time-compressed speech perception. However, there was no statistical correlation between digit span results and either the SHSE total or its subcategories. A confirmatory factor analysis supported three factors in SHSE. Conclusion We found that the developed SHSE had valuable internal consistency, test–retest reliability, and convergent and construct

  10. Phenotypic variability in a seven-generation Swedish family segregating autosomal dominant hearing impairment due to a novel EYA4 frameshift mutation

    DEFF Research Database (Denmark)

    Frykholm, Carina; Klar, Joakim; Arnesson, Hanna;

    2015-01-01

    Linkage to an interval overlapping the DFNA10 locus on chromosome 6q22-23 was found through genome wide linkage analysis in a seven-generation Swedish family segregating postlingual, autosomal dominant nonsyndromic sensorineural hearing impairment. A novel heterozygous frame-shift mutation (c.579...

  11. Hearing Aids

    Science.gov (United States)

    ... prefer the open-fit hearing aid because their perception of their voice does not sound “plugged up.” ... My voice sounds too loud. The “plugged-up” sensation that causes a hearing aid user’s voice to ...

  12. An allograft mouse model for the study of hearing loss secondary to vestibular schwannoma growth.

    Science.gov (United States)

    Bonne, Nicolas-Xavier; Vitte, Jérémie; Chareyre, Fabrice; Karapetyan, Gevorg; Khankaldyyan, Vazgen; Tanaka, Karo; Moats, Rex A; Giovannini, Marco

    2016-08-01

    Vestibular schwannoma is a benign neoplasm arising from the Schwann cell sheath of the auditory-vestibular nerve. It most commonly affects both sides in the genetic condition Neurofibromatosis type 2, causing progressive high frequency sensorineural hearing loss. Here, we describe a microsurgical technique and stereotactic coordinates for schwannoma cell grafting in the vestibular nerve region that recapitulates local tumor growth in the cerebellopontine angle and inner auditory canal with resulting hearing loss. Tumor growth was monitored by bioluminescence and MRI in vivo imaging, and hearing assessed by auditory brainstem responses. These techniques, by potentially enabling orthotopic grafting of a variety of cell lines will allow studies on the pathogenesis of tumor-related hearing loss and preclinical drug evaluation, including hearing endpoints, for NF2-related and sporadic schwannomas. PMID:27177628

  13. Congenital sensorineural deafness in Australian stumpy-tail cattle dogs is an autosomal recessive trait that maps to CFA10.

    Directory of Open Access Journals (Sweden)

    Susan Sommerlad

    Full Text Available BACKGROUND: Congenital sensorineural deafness is an inherited condition found in many dog breeds, including Australian Stumpy-tail Cattle Dogs (ASCD. This deafness is evident in young pups and may affect one ear (unilateral or both ears (bilateral. The genetic locus/loci involved is unknown for all dog breeds. The aims of this study were to determine incidence, inheritance mechanism, and possible association of congenital sensorineural deafness with coat colour in ASCD and to identify the genetic locus underpinning this disease. METHODOLOGY/PRINCIPAL FINDINGS: A total of 315 ASCD were tested for sensorineural deafness using the brain stem auditory evoked response (BAER test. Disease penetrance was estimated directly, using the ratio of unilaterally to bilaterally deaf dogs, and segregation analysis was performed using Mendel. A complete genome screen was undertaken using 325 microsatellites spread throughout the genome, on a pedigree of 50 BAER tested ASCD in which deafness was segregating. Fifty-six dogs (17.8% were deaf, with 17 bilaterally and 39 unilaterally deaf. Unilaterally deaf dogs showed no significant left/right bias (p = 0.19 and no significant difference was observed in frequencies between the sexes (p = 0.18. Penetrance of deafness was estimated as 0.72. Testing the association of red/blue coat colour and deafness without accounting for pedigree structure showed that red dogs were 1.8 times more likely to be deaf (p = 0.045. The within family association between red/blue coat colour and deafness was strongly significant (p = 0.00036, with red coat colour segregating more frequently with deafness (COR = 0.48. The relationship between deafness and coat speckling approached significance (p = 0.07, with the lack of statistical significance possibly due to only four families co-segregating for both deafness and speckling. The deafness phenotype was mapped to CFA10 (maximum linkage peak on CFA10 -log10 p

  14. Genetic and pharmacological intervention for treatment/prevention of hearing loss

    OpenAIRE

    Cotanche, Douglas A.

    2008-01-01

    Twenty years ago it was first demonstrated that birds could regenerate their cochlear hair cells following noise damage or aminoglycoside treatment. An understanding of how this structural and functional regeneration occurred might lead to the development of therapies for treatment of sensorineural hearing loss in humans. Recent experiments have demonstrated that noise exposure and aminoglycoside treatment lead to apoptosis of the hair cells. In birds, this programmed cell death induces the a...

  15. Phenotype and genotype analysis of a Chinese family with prelingual X-linked hereditary hearing impairment

    Institute of Scientific and Technical Information of China (English)

    HAN Bing; CHENG Jing; YANG Shu-zhi; CAO Ju-yang; SHEN Wei-dong; JI Fei; KANG Dong-yang; ZHANG Xin; DAI Pu; YUAN Hui-jun

    2009-01-01

    Background X-linked hearing impairment is clinically and genetically a heterogeneous disease.Although many disorders manifest with hearing loss,a limited number of sex-linked loci and only one gene (POU3F4) have been shown to be implicated in X-linked non-syndromic hearing impairment.In the present study,we have performed a clinical and genetic analysis of a Chinese family with X-linked non-syndromic hearing loss,with emphasis on audiological findings and genomic mapping.Methods The clinical features of Family JX01 were evaluated by physical and audiometric examination in eighteen family members.Mutation screening of POU3F4 was identified by polymerase chain reaction (PCR) amplification and sequencing.Molecular evaluation consisted of X-chromosome wide genotyping by microsatellite makers (STR),followed by analyzing using MLINK computer program.Results Five affected males demonstrated bilateral,symmetrical sensorineural and profound hearing loss.The hearing impairment started prelingual.The female carriers did not have any complain of hearing loss,however,two of them were tested with milder loss with high frequency.No causative mutations in POU3F4 gene were detected by DNA sequencing.Linkage analysis indicated that the responsible gene was linked to locus DXS1227 (maximum lod score=2.04 at θ=0).Conclusions The affected males in Family JX01 have profound prelingual sensorineural hearing impairment,In addition,two female carriers showed mild to moderate hearing losses.However,none of females complained of any hearing loss.Analysis of hereditary deafness in this family mapped most compatibly to the Xq27.2.

  16. Neurological complications of acute multifocal placoid pigment epitheliopathy.

    Science.gov (United States)

    Brownlee, W J; Anderson, N E; Sims, J; Pereira, J A

    2016-09-01

    Acute multifocal placoid pigment epitheliopathy (AMPPE) is an autoimmune chorioretinal disease that can be complicated by neurological involvement. There is limited information on this potentially treatable condition in the neurological literature. The objective of this patient series is to describe the neurological complications of AMPPE. We retrospectively identified patients with neurological complications of AMPPE seen at Auckland Hospital between 2008 and 2013 and summarised cases in the literature between 1976 and 2013. We identified five patients with neurological complications of AMPPE at Auckland Hospital and 47 reported patients. These patients demonstrated a spectrum of neurological involvement including isolated headache, stroke or transient ischaemic attack, seizures, venous sinus thrombosis, optic neuritis, sensorineural hearing loss and peripheral vestibular disorder. We propose criteria to define AMPPE with neurological complications. A cerebrospinal fluid (CSF) lymphocytosis in a patient with isolated headache may predict the development of cerebrovascular complications of AMPPE. Patients with cerebrovascular complications of AMPPE have a poor prognosis with high rates of death and neurological disability among survivors. Predictors of poor outcome in those who develop neurological complications of AMPPE are a relapsing course, generalised seizures and multifocal infarction on MRI. All patients with neurological complications of AMPPE, including headache alone, should be investigated with an MRI brain and CSF examination. Patients with focal neurological symptoms should receive intravenous (IV) methylprednisolone followed by a tapering course of oral steroids for at least 3months. Patients with AMPPE and an isolated headache with a CSF pleocytosis should be treated with oral steroids. PMID:27183958

  17. Sudden hearing loss and vertigo after tooth extraction successfully treated with combined therapy including HBO2: a case report.

    Science.gov (United States)

    Yilmaz, Huseyin Baki; Erdogan, Raziye Banu Atalay; Paksoy, Mustafa; Sanli, Arif

    2015-01-01

    Sudden sensorineural hearing loss (SSNHL) is a decrease in hearing of at least 30 dB that occurs within three days and which affects at least three consecutive frequencies in either ear or both ears. This case report describes a woman who had sudden hearing loss and vertigo in the right ear after tooth extraction. As the first-line therapy, systemic and intratympanic steroid injections were used this led to a slight improvement; however, the majority of improvement in hearing was not observed until hyperbaric oxygen (HBO2) therapy was instituted on the 20th day of hearing loss. Sudden hearing loss and vertigo after tooth extraction is an otologic emergency and early evaluation and treatment are effective. HBO2, although employed beyond the Undersea and Hyperbaric Medical Society's recommended initial 14 days of symptom onset, very was effective for this particular case.

  18. Treatment for Progressive Hearing Loss Due to Paget's Disease of Bone - A Case Report and Literature Review.

    Science.gov (United States)

    Aoki, Mitsuhiro; Tanahashi, Shigeaki; Mizuta, Keisuke; Kato, Hiroki

    2015-12-01

    Paget's disease is a common bone remodeling disorder that typically begins with excessive bone resorption in the elderly. Bilateral progressive hearing loss is the most frequently encountered complication of Paget's disease. The types of hearing loss identified by audiometry are conductive, sensorineural, or both. However, the precise mechanism of hearing loss remains unclear, and the treatment has been controversial. We present a 73-year-old man who suffered from bilateral progressive hearing loss due to Paget's disease. Potent bisphosphonates, oral risedronate in daily adjusted dosages for 6 months, did not decrease or suppress the worsening of the hearing loss. The Nucleus CI24 Contour electrode array was successfully inserted on the left side without surgical and postoperative complications. The Japanese open set monosyllable word recognition test in a sound field at 65 dB had a result of 74%. This cochlear implantation can be an indication for cases of profound hearing loss due to Paget's disease. PMID:26915163

  19. Otoacoustic Emissions in Sudden Sensorineural Hearing Loss: Changes of Measures with Treatment

    Directory of Open Access Journals (Sweden)

    Shadman Nemati

    2011-01-01

    In TEOAEs, the mean overall correlation (reproducibility and the mean overall strength in involved ears were 10.96±23.36 and 0.99±3.45 dB, respectively, before the treatment, which reached 22.88±36.55 and 1.85±5.3, respectively, after the treatment (P>0.05. Significant difference between “correlation score” (average of correlations at 3-4 involved frequencies before and after treatment was found: 6.52 ±18.19 vs. 21.67±37.8 (P

  20. Inflammatory and immune responses in the cochlea: potential therapeutic targets for sensorineural hearing loss

    Directory of Open Access Journals (Sweden)

    Masato eFujioka

    2014-12-01

    Full Text Available The inner ear was previously assumed to be an immune-privileged organ due to the existence of its tight junction-based blood-labyrinth barrier. However, studies performed during the past decade revealed that the mesenchymal region of the cochlea, including its lateral wall, is a common site of inflammation. Neutrophils do not enter this region, which is consistent with the old dogma; however, bone marrow-derived resident macrophages are always present in the spiral ligament of the lateral wall and are activated in response to various types of insults, including noise exposure, ischemia, mitochondrial damage and surgical stress. Recent studies have also revealed another type of immune cell, called perivascular melanocyte-like macrophages (PVM/Ms, in the stria vascularis. These dedicated antigen-presenting cells also control vascular contraction and permeability. This review discusses a series of reports regarding inflammatory/immune cells in the cochlear lateral wall, the pathways involved in cochlear damage and their potential as therapeutic targets.

  1. Determinants of sensorineural hearing loss in chronic middle-ear disease.

    Science.gov (United States)

    Kasliwal, Neeraj; Joshi, Sanjeev; Pareek, S M

    2004-10-01

    A statistical study was carried out on SNHL in CSOM. The study group consisted of 1,828 patients suffering from CSOM who underwent surgery at our centre from 1982 to 2001, out of these 510 cases with unilateral CSOM were selected for this study by a strict selection criteria so as to eliminate covariables such as exposure to acoustic trauma, head injury, previous ear surgery and hereditary causes. The healthy ear served as control. We determined the average SNHL in relation to the age of onset, duration of disease, examining it in relation to other eventual aural complications such as cholesteatoma, ossicular chain erosion und otorrhea.On the basis of data obtained we observed consistent co-relation between severity of SNHL and duration of the disease, presence of cholesteatoma, ossicular erosion, attic and subtotal perforations. These findings suggest that more severe middle ear disease may result in SNHL and thus early intervention in cases of chronic suppurative Otitis media is desired. PMID:23120094

  2. Hearing Aid

    Science.gov (United States)

    ... and Food and Drug Administration Staff FDA permits marketing of new laser-based hearing aid with potential ... feeds Follow FDA on Twitter Follow FDA on Facebook View FDA videos on YouTube View FDA photos ...

  3. Fish Hearing.

    Science.gov (United States)

    Blaxter, J. H. S.

    1980-01-01

    Provides related information about hearing in fish, including the sensory stimulus of sound in the underwater environment, mechanoreceptors in fish, pressure perception and the swimbladder, specializations in sound conduction peculiar to certain fish families. Includes numerous figures. (CS)

  4. Hearing Loss

    Science.gov (United States)

    ... the choices that can help people with hearing problems. home | health topics A-Z | videos A-Z | training | about us | contact us | site map National Institute on Aging | U.S. National Library of Medicine | National Institutes of ...

  5. Tone Task Proves Blind Hear Better--Early vision loss leads to keener hearing

    Institute of Scientific and Technical Information of China (English)

    Michael Hopkin; 于明霞

    2004-01-01

    @@ It is no coincidence① that so many piano-tuners② are blind. Folklore③ says their lack of sight gives them acute hearing, ideally suited to the task. Now neuroscientists in Canada have shown that the sightless really do hear notes more precisely if they went blind when they were very young.

  6. Musicians change their tune: how hearing loss alters the neural code.

    Science.gov (United States)

    Parbery-Clark, Alexandra; Anderson, Samira; Kraus, Nina

    2013-08-01

    Individuals with sensorineural hearing loss have difficulty understanding speech, especially in background noise. This deficit remains even when audibility is restored through amplification, suggesting that mechanisms beyond a reduction in peripheral sensitivity contribute to the perceptual difficulties associated with hearing loss. Given that normal-hearing musicians have enhanced auditory perceptual skills, including speech-in-noise perception, coupled with heightened subcortical responses to speech, we aimed to determine whether similar advantages could be observed in middle-aged adults with hearing loss. Results indicate that musicians with hearing loss, despite self-perceptions of average performance for understanding speech in noise, have a greater ability to hear in noise relative to nonmusicians. This is accompanied by more robust subcortical encoding of sound (e.g., stimulus-to-response correlations and response consistency) as well as more resilient neural responses to speech in the presence of background noise (e.g., neural timing). Musicians with hearing loss also demonstrate unique neural signatures of spectral encoding relative to nonmusicians: enhanced neural encoding of the speech-sound's fundamental frequency but not of its upper harmonics. This stands in contrast to previous outcomes in normal-hearing musicians, who have enhanced encoding of the harmonics but not the fundamental frequency. Taken together, our data suggest that although hearing loss modifies a musician's spectral encoding of speech, the musician advantage for perceiving speech in noise persists in a hearing-impaired population by adaptively strengthening underlying neural mechanisms for speech-in-noise perception.

  7. Hearing Loss in Infants with Microcephaly and Evidence of Congenital Zika Virus Infection - Brazil, November 2015-May 2016.

    Science.gov (United States)

    Leal, Mariana C; Muniz, Lilian F; Ferreira, Tamires S A; Santos, Cristiane M; Almeida, Luciana C; Van Der Linden, Vanessa; Ramos, Regina C F; Rodrigues, Laura C; Neto, Silvio S Caldas

    2016-09-02

    Congenital infection with Zika virus causes microcephaly and other brain abnormalities (1). Hearing loss associated with other congenital viral infections is well described; however, little is known about hearing loss in infants with congenital Zika virus infection. A retrospective assessment of a series of 70 infants aged 0-10 months with microcephaly and laboratory evidence of Zika virus infection was conducted by the Hospital Agamenon Magalhães in Brazil and partners. The infants were enrolled during November 2015-May 2016 and had screening and diagnostic hearing tests. Five (7%) infants had sensorineural hearing loss, all of whom had severe microcephaly; however, one child was tested after receiving treatment with an ototoxic antibiotic. If this child is excluded, the prevalence of sensorineural hearing loss was 5.8% (four of 69), which is similar to that seen in association with other congenital viral infections. Additional information is needed to understand the prevalence and spectrum of hearing loss in children with congenital Zika virus infection; all infants born to women with evidence of Zika virus infection during pregnancy should have their hearing tested, including infants who appear normal at birth.

  8. Hearing Loss in Infants with Microcephaly and Evidence of Congenital Zika Virus Infection - Brazil, November 2015-May 2016.

    Science.gov (United States)

    Leal, Mariana C; Muniz, Lilian F; Ferreira, Tamires S A; Santos, Cristiane M; Almeida, Luciana C; Van Der Linden, Vanessa; Ramos, Regina C F; Rodrigues, Laura C; Neto, Silvio S Caldas

    2016-01-01

    Congenital infection with Zika virus causes microcephaly and other brain abnormalities (1). Hearing loss associated with other congenital viral infections is well described; however, little is known about hearing loss in infants with congenital Zika virus infection. A retrospective assessment of a series of 70 infants aged 0-10 months with microcephaly and laboratory evidence of Zika virus infection was conducted by the Hospital Agamenon Magalhães in Brazil and partners. The infants were enrolled during November 2015-May 2016 and had screening and diagnostic hearing tests. Five (7%) infants had sensorineural hearing loss, all of whom had severe microcephaly; however, one child was tested after receiving treatment with an ototoxic antibiotic. If this child is excluded, the prevalence of sensorineural hearing loss was 5.8% (four of 69), which is similar to that seen in association with other congenital viral infections. Additional information is needed to understand the prevalence and spectrum of hearing loss in children with congenital Zika virus infection; all infants born to women with evidence of Zika virus infection during pregnancy should have their hearing tested, including infants who appear normal at birth. PMID:27585248

  9. Efficient estimates of cochlear hearing loss parameters in individual listeners

    DEFF Research Database (Denmark)

    Fereczkowski, Michal; Jepsen, Morten Løve; Dau, Torsten

    2013-01-01

    It has been suggested that the level corresponding to the knee-point of the basilar membrane (BM) input/output (I/O) function can be used to estimate the amount of inner- and outer hair-cell loss (IHL, OHL) in listeners with a moderate cochlear hearing impairment Plack et al. (2004). According...... to Jepsen and Dau (2011) IHL + OHL = HLT [dB], where HLT stands for total hearing loss. Hence having estimates of the total hearing loss and OHC loss, one can estimate the IHL. In the present study, results from forward masking experiments based on temporal masking curves (TMC; Nelson et al., 2001...... estimates of the knee-point level. Further, it is explored whether it is possible to estimate the compression ratio using only on-frequency TMCs. 10 normal-hearing and 10 hearing-impaired listeners (with mild-to-moderate sensorineural hearing loss) were tested at 1, 2 and 4 kHz. The results showed...

  10. Using Speech Recall in Hearing Aid Fitting and Outcome Evaluation Under Ecological Test Conditions.

    Science.gov (United States)

    Lunner, Thomas; Rudner, Mary; Rosenbom, Tove; Ågren, Jessica; Ng, Elaine Hoi Ning

    2016-01-01

    In adaptive Speech Reception Threshold (SRT) tests used in the audiological clinic, speech is presented at signal to noise ratios (SNRs) that are lower than those generally encountered in real-life communication situations. At higher, ecologically valid SNRs, however, SRTs are insensitive to changes in hearing aid signal processing that may be of benefit to listeners who are hard of hearing. Previous studies conducted in Swedish using the Sentence-final Word Identification and Recall test (SWIR) have indicated that at such SNRs, the ability to recall spoken words may be a more informative measure. In the present study, a Danish version of SWIR, known as the Sentence-final Word Identification and Recall Test in a New Language (SWIRL) was introduced and evaluated in two experiments. The objective of experiment 1 was to determine if the Swedish results demonstrating benefit from noise reduction signal processing for hearing aid wearers could be replicated in 25 Danish participants with mild to moderate symmetrical sensorineural hearing loss. The objective of experiment 2 was to compare direct-drive and skin-drive transmission in 16 Danish users of bone-anchored hearing aids with conductive hearing loss or mixed sensorineural and conductive hearing loss. In experiment 1, performance on SWIRL improved when hearing aid noise reduction was used, replicating the Swedish results and generalizing them across languages. In experiment 2, performance on SWIRL was better for direct-drive compared with skin-drive transmission conditions. These findings indicate that spoken word recall can be used to identify benefits from hearing aid signal processing at ecologically valid, positive SNRs where SRTs are insensitive.

  11. Using Speech Recall in Hearing Aid Fitting and Outcome Evaluation Under Ecological Test Conditions.

    Science.gov (United States)

    Lunner, Thomas; Rudner, Mary; Rosenbom, Tove; Ågren, Jessica; Ng, Elaine Hoi Ning

    2016-01-01

    In adaptive Speech Reception Threshold (SRT) tests used in the audiological clinic, speech is presented at signal to noise ratios (SNRs) that are lower than those generally encountered in real-life communication situations. At higher, ecologically valid SNRs, however, SRTs are insensitive to changes in hearing aid signal processing that may be of benefit to listeners who are hard of hearing. Previous studies conducted in Swedish using the Sentence-final Word Identification and Recall test (SWIR) have indicated that at such SNRs, the ability to recall spoken words may be a more informative measure. In the present study, a Danish version of SWIR, known as the Sentence-final Word Identification and Recall Test in a New Language (SWIRL) was introduced and evaluated in two experiments. The objective of experiment 1 was to determine if the Swedish results demonstrating benefit from noise reduction signal processing for hearing aid wearers could be replicated in 25 Danish participants with mild to moderate symmetrical sensorineural hearing loss. The objective of experiment 2 was to compare direct-drive and skin-drive transmission in 16 Danish users of bone-anchored hearing aids with conductive hearing loss or mixed sensorineural and conductive hearing loss. In experiment 1, performance on SWIRL improved when hearing aid noise reduction was used, replicating the Swedish results and generalizing them across languages. In experiment 2, performance on SWIRL was better for direct-drive compared with skin-drive transmission conditions. These findings indicate that spoken word recall can be used to identify benefits from hearing aid signal processing at ecologically valid, positive SNRs where SRTs are insensitive. PMID:27355764

  12. Hearing loss: Can it be neurobrucellosis?

    Directory of Open Access Journals (Sweden)

    Hacer Aktürk

    2015-09-01

    Full Text Available Brucellosis is a zoonotic infection transmitted from animals to humans mostly by ingestion through infected food products, direct contact with an infected animal. It can involve any organ system and present with a broad spectrum of clinical findings. Central nervous system involvement, so called neurobrucellosis, is rarely seen in pediatric age population. Neurologic anifestations may also show great variability and lead to confusion in diagnosis. Here, we report a case of chronic neurobrucellosis presenting with gradually worsening sensorineural hearing loss and subsequently developed meningitis. A 15 years old girl was diagnosed as neurobrucellosis with the aid of positive serum and CSF agglutination tests, in addition to clinical findings and positive exposure history to unpasteurized dairy products. Clinicians serving in endemic areas should consider brucellosis in differential diagnosis of such atypical clinical presentations to avoid delay in diagnosis and treatment. J Microbiol Infect Dis 2015;5(3: 125-128

  13. Temporal integration of loudness in listeners with hearing losses of primarily cochlear origin

    DEFF Research Database (Denmark)

    Buus, Søren; Florentine, Mary; Poulsen, Torben

    1999-01-01

    To investigate how hearing loss of primarily cochlear origin affects the loudness of brief tones, loudness matches between 5- and 200-ms tones were obtained as a function of level for 15 listeners with cochlear impairments and for seven age-matched controls. Three frequencies, usually 0.5, 1, and 4......-frequency hearing losses (slopes >50 dB/octave) showed larger-than-normal maximal amounts of temporal integration (40 to 50 dB). This finding is consistent with the shallow loudness functions predicted by our excitation-pattern model for impaired listeners [, in Modeling Sensorineural Hearing Loss, edited by W....... Jesteadt (Erlbaum, Mahwah, NJ, 1997), pp. 187–198]. Loudness functions derived from impaired listeners' temporal-integration functions indicate that restoration of loudness in listeners with cochlear hearing loss usually will require the same gain whether the sound is short or long. ©1999 Acoustical...

  14. Universal newborn hearing screening: preliminary experience at the University Hospital of Cagliari

    Directory of Open Access Journals (Sweden)

    Giulia Pinna

    2012-10-01

    Full Text Available Bilateral congenital or acquired sensorineural hearing loss is a pathological condition affecting 1-2 children per 1,000 live births; it represents a major issue in public health because its late identification can negatively affect speech and language development. The aim of hearing screening is to obtain diagnosis and management of hearing loss as soon as possible; in fact early diagnosis and treatment allow children with congenital hearing impairment to acquire adequate linguistic competence. The present study reports our preliminary experience in newborn hearing screening at Neonatology services of University of Cagliari (Italy. During the first semester of surveillance, between January 2012 and June 2012, hearing screening was performed on a total of 901 babies using two different methods, TEOAEs in healthy neonates and automated ABR in high-risk babies. All infants were screened prior to hospital discharge; in some cases, especially for preterm infants of Neonatal Intensive Care Unit and Puericulture Institute, the screening was performed after discharge, to achieve a possible better global and acoustic maturation; 5 cases of hearing impairment were found. In the present study the Authors confirmed that it is possible to start a universal hearing screening in a relatively short time reaching the percentages suggested by Joint Committee on Infant Hearing.

  15. Correlative mRNA and protein expression of middle and inner ear inflammatory cytokines during mouse acute otitis media.

    Science.gov (United States)

    Trune, Dennis R; Kempton, Beth; Hausman, Frances A; Larrain, Barbara E; MacArthur, Carol J

    2015-08-01

    Although the inner ear has long been reported to be susceptible to middle ear disease, little is known of the inflammatory mechanisms that might cause permanent sensorineural hearing loss. Recent studies have shown inner ear tissues are capable of expressing inflammatory cytokines during otitis media. However, little quantitative information is available concerning cytokine gene expression in the inner ear and the protein products that result. Therefore, this study was conducted of mouse middle and inner ear during acute otitis media to measure the relationship between inflammatory cytokine genes and their protein products with quantitative RT-PCR and ELISA, respectively. Balb/c mice were inoculated transtympanically with heat-killed Haemophilus influenzae and middle and inner ear tissues collected for either quantitative RT-PCR microarrays or ELISA multiplex arrays. mRNA for several cytokine genes was significantly increased in both the middle and inner ear at 6 h. In the inner ear, these included MIP-2 (448 fold), IL-6 (126 fold), IL-1β (7.8 fold), IL-10 (10.7 fold), TNFα (1.8 fold), and IL-1α (1.5 fold). The 24 h samples showed a similar pattern of gene expression, although generally at lower levels. In parallel, the ELISA showed the related cytokines were present in the inner ear at concentrations higher by 2-122 fold higher at 18 h, declining slightly from there at 24 h. Immunohistochemistry with antibodies to a number of these cytokines demonstrated they occurred in greater amounts in the inner ear tissues. These findings demonstrate considerable inflammatory gene expression and gene products in the inner ear following acute otitis media. These higher cytokine levels suggest one potential mechanism for the permanent hearing loss seen in some cases of acute and chronic otitis media.

  16. Pegylated interferon/ribavirin-associated sudden hearing loss in a patient with chronic hepatitis C in Brazil

    Directory of Open Access Journals (Sweden)

    Maria Cassia Jacintho Mendes-Corrêa

    2011-02-01

    Full Text Available Sudden hearing loss is defined as a sensorineural hearing loss, equal to or greater than 30 dB, at three or more consecutive frequencies, which takes place within 72 hours. Both peginterferon and ribavirin are well-known to be associated with significant adverse effects, but sudden hearing loss is uncommon. We report a 65-year-old male patient who developed sudden-onset hearing loss during combination therapy with pegylated interferon-alpha and ribavirin for chronic hepatitis C. Peginterferon and ribavirin may cause sudden hearing loss that may not recover after discontinuation of therapy. Immediate treatment for all possible etiologies is essential, along with targeted investigations and early referral for an Ear, Nose and Throat specialist. Physicians should be aware of the possible ototoxic effects of peginterferon and ribavirin combination therapy requiring appropriate surveillance.

  17. A PROSPECTIVE STUDY OF PREVALENCE OF VARIOUS CAUSES IN PATIENTS PRESENTING WITH CONDUCTIVE TYPE OF HEARING IMPAIRMENT

    Directory of Open Access Journals (Sweden)

    Naga Manohar

    2014-12-01

    Full Text Available INTRODUCTION: Deafness is the most common presenting complaint in patient presenting to ENT OPD with complaints of ear. Deafness is a potentially morbid condition causing significant problem to the patient in their day-to-day life and livelihood. AIM: This study was undertaken to know the incidence of various diseases presenting as deafness, so that, epidemiological data can be secured and it is helpful to channel the resources and treatment modalities in the right direction. SETTINGS AND DESIGN: The study was carried out in a Teritiary hospital, in Vizianagaram, Andhra Pradesh. It is a prospective study, undertaken to know the prevalence. MATERIALS AND METHODS: Patients presenting to ENT OPD from Sept 2012 to Sept 2014, with a chief complaint of deafness were included in this study. All the Patients were subjected to thorough clinical examination, necessary investigations, viz. pure tone audiometry, Examination under microscopy and wet mopping by way of syringing. RESULTS: Out of the 400 patients included for this study, 272 patients (68% were found to be suffering from Conductive hearing loss; whereas 138 patients (34.5% were found to be suffering from Sensorineural hearing loss. Conductive hearing loss was most common in 20-30 age group in males and 30-40 age group in females; that too middle ear disease were more common than external ear; i.e. 175 patients out of 262 (66.7% had a disease in the middle ear, 87 patients (33.2% had a external ear pathology. External ear disease was earwax or keratosis obturans, (55.1%, the rest contributed by Otomycosis (34.4% and malformed ears (10.3%. Diseases of middle ear were distributed as Acute otitis media (17.7%, Chronic otitis media (28%, Otitis media with effusion (50.2%, Fixation pathology (15.4%, Other causes (5.1%. CONCLUSION: Conductive hearing loss was most common in the middle age groups, between 20-40 yrs of age, females, and more commonly due to a pathology in the middle ear, Otitis media

  18. Hearing Loss in Osteogenesis Imperfecta: Characteristics and Treatment Considerations

    Directory of Open Access Journals (Sweden)

    Joseph P. Pillion

    2011-01-01

    Full Text Available Osteogenesis imperfecta (OI is the most common heritable disorder of connective tissue. It is associated with fractures following relatively minor injury, blue sclerae, dentinogenesis imperfecta, increased joint mobility, short stature, and hearing loss. Structures in the otic capsule and inner ear share in the histologic features common to other skeletal tissues. OI is due to mutations involving several genes, the most commonly involved are the COL1A1 or COL1A2 genes which are responsible for the synthesis of the proalpha-1 and proalpha-2 polypeptide chains that form the type I collagen triple helix. A genotype/phenotype relationship to hearing loss has not been established in OI. Hearing loss is commonly found in OI with prevalence rates ranging from 50 to 92% in some studies. Hearing loss in OI may be conductive, mixed, or sensorineural and is more common by the second or third decade. Treatment options such as hearing aids, stapes surgery, and cochlear implants are discussed.

  19. Could Neonatal Hypernatremia Dehydration Influence Hearing Status?

    OpenAIRE

    Hassan Boskabadi; Farnaz Anvarifar; Navid Nourizadeh

    2014-01-01

    Introduction: Neonatal hypernatremia dehydration (NHD) is a dangerous condition in neonates, which is accompanied by acute complications (renal failure, cerebral edema, and cerebral hemorrhage) and chronic complications (developmental delay). Children begin learning language from birth, and hearing impairment interferes with this process. We assessed the hearing status of infants with hypernatremia dehydration.   Materials and Methods: In a case-control study in 110 infants presenting at the...

  20. Informational Masking in Normal-Hearing and Hearing-Impaired Listeners Measured in a Nonspeech Pattern Identification Task.

    Science.gov (United States)

    Roverud, Elin; Best, Virginia; Mason, Christine R; Swaminathan, Jayaganesh; Kidd, Gerald

    2016-01-01

    Individuals with sensorineural hearing loss (SNHL) often experience more difficulty with listening in multisource environments than do normal-hearing (NH) listeners. While the peripheral effects of sensorineural hearing loss certainly contribute to this difficulty, differences in central processing of auditory information may also contribute. To explore this issue, it is important to account for peripheral differences between NH and these hearing-impaired (HI) listeners so that central effects in multisource listening can be examined. In the present study, NH and HI listeners performed a tonal pattern identification task at two distant center frequencies (CFs), 850 and 3500 Hz. In an attempt to control for differences in the peripheral representations of the stimuli, the patterns were presented at the same sensation level (15 dB SL), and the frequency deviation of the tones comprising the patterns was adjusted to obtain equal quiet pattern identification performance across all listeners at both CFs. Tonal sequences were then presented at both CFs simultaneously (informational masking conditions), and listeners were asked either to selectively attend to a source (CF) or to divide attention between CFs and identify the pattern at a CF designated after each trial. There were large differences between groups in the frequency deviations necessary to perform the pattern identification task. After compensating for these differences, there were small differences between NH and HI listeners in the informational masking conditions. HI listeners showed slightly greater performance asymmetry between the low and high CFs than did NH listeners, possibly due to central differences in frequency weighting between groups. PMID:27059627

  1. Frequency of Sensory Neural Hearing Loss in Major Beta-Thalassemias in Southern Iran

    Directory of Open Access Journals (Sweden)

    Seyed-Taghi Heydari

    2010-09-01

    Full Text Available Objective:The thalassemias are among the most common genetic disorders worldwide, occurring more frequently in the Mediterranean region. The aim of this study was to determined frequency of sensory-neural hearing loss in major ß- thalassemias transfusion dependent patients in south of Iran. Methods:A cross sectional study on 308 cases of major beta-thalassemia patients referring to Thalassemia Center of Shiraz University of Medical Sciences between 2006-2007 years. The diagnosis of ß- thalassemia major was based on clinical history, complete blood count and hemoglobine electrophoresis. Clinical data such as serum ferritin level, deferoxamine (DFO dose, mean daily doses of DFO (mg/kg and audiometric variables was recorded. Findings:Out of 308 cases, 283 (96.5% had normal hearing and 10 (3.5% sensorineural hearing loss. There was no statically significant difference between two groups regarding mean age, weight, age at the first blood transfusion, age at the first DFO infusion. Conclusion:We found the lowest incidence of sensorineural hearing loss in a large population of patients suffered from major thalassemia who received DFO. We show that DFO is not ototoxic at a low dose. When considering all related literature, as a whole there has been much critical misrepresentation about DFO ototoxicity.

  2. Frequency of Sensory Neural Hearing Loss in Major Beta-Thalassemias in Southern Iran

    Science.gov (United States)

    Faramarzi, Abolhassan; Karimi, Mehran; Heydari, Seyed-Taghi; Shishegar, Mahmoud; Kaviani, Masoud

    2010-01-01

    Objective The thalassemias are among the most common genetic disorders worldwide, occurring more frequently in the Mediterranean region. The aim of this study was to determined frequency of sensory-neural hearing loss in major ß- thalassemias transfusion dependent patients in south of Iran. Methods A cross sectional study on 308 cases of major beta-thalassemia patients referring to Thalassemia Center of Shiraz University of Medical Sciences between 2006–2007 years. The diagnosis of ß- thalassemia major was based on clinical history, complete blood count and hemoglobine electrophoresis. Clinical data such as serum ferritin level, deferoxamine (DFO) dose, mean daily doses of DFO (mg/kg) and audiometric variables was recorded. Findings Out of 308 cases, 283 (96.5%) had normal hearing and 10 (3.5%) sensorineural hearing loss. There was no statically significant difference between two groups regarding mean age, weight, age at the first blood transfusion, age at the first DFO infusion. Conclusion We found the lowest incidence of sensorineural hearing loss in a large population of patients suffered from major thalassemia who received DFO. We show that DFO is not ototoxic at a low dose. When considering all related literature, as a whole there has been much critical misrepresentation about DFO ototoxicity. PMID:23056722

  3. Hearing rehabilitation with single-stage bilateral vibroplasty in a child with Franceschetti syndrome.

    Science.gov (United States)

    Sargsyan, Sona; Rahne, Torsten; Kösling, Sabrina; Eichler, Gerburg; Plontke, Stefan K

    2014-05-01

    Hearing is of utmost importance for normal speech and social development. Even children who have mild or unilateral permanent hearing loss may experience difficulties with understanding speech, as well as problems with educational and psycho-social development. The increasing advantages of middle-ear implant technologies are opening new perspectives for restoring hearing. Active middle-ear implants can be used in children and adolescents with hearing loss. In addition to the well-documented results for improving speech intelligibility and quality of hearing in sensorineural hearing loss active middle-ear implants are now successfully used in patients with conductive and mixed hearing loss. In this article we present a case of successful, single-stage vibroplasty, on the right side with the fixation of the FMT on the stapes and PORP CLiP vibroplasty on the left side in a 6-year-old girl with bilateral mixed hearing loss and multiple dyslalia associated with Franceschetti syndrome (mandibulofacial dysostosis). CT revealed bilateral middle-ear malformations as well as an atretic right and stenotic left external auditory canal. Due to craniofacial dysmorphia airway and (post)operative, management is significantly more difficult in patients with a Franceschetti syndrome which in this case favoured a single-stage bilateral procedure. No intra- or postoperative surgical complications were reported. The middle-ear implants were activated 4 weeks after surgery. In the audiological examination 6 months after surgery, the child showed 100% speech intelligibility with activated implants on each side.

  4. HEARING LOSS IN CHRONIC RENAL FAILURE - AN ASSESSMENT OF MULTIPLE AETIOLOGICAL FACTORS

    Directory of Open Access Journals (Sweden)

    Suja Sreedharan

    2015-04-01

    Full Text Available Introduction: Sensorineural hearing loss in chronic renal failure is believed to be of multifactorial etiology. Associated hypertension and diabetes mellitus, use of ototoxic drugs, hemodialysis and the changes in metabolic parameters are the various reasons quoted for the hearing loss. Objectives: Our study attempts to correlate the hearing thresholds with the multiple parameters like blood levels of urea, serum creatinine, sodium, potassium, calcium and hemoglobin values incriminated in decreased hearing in CRF patients. Materials and methods:Prospective study of 25 patients receiving treatment for CRF. The threshold of the worsen ear was considered for statistical analysis. Results:18% of the patients at low frequencies (250 and 500 Hz, 32% of the patients at mid-frequencies (1000 and 2000 Hz, and 72% of the patients at high frequencies (4000 and 8000 Hz had decreased hearing for both bone and air conduction hearing. We found a positive correlation between hearing loss and increasing number of hemodialysis sessions, the levels of blood urea, serum creatinine, serum sodium and use of ototoxic drugs; while serum calcium, serum potassium and hemoglobin levels had a negative correlation. Conclusion:Though the management of CRF including hemodialysis has been refined, hearing loss continues to cause disability in CRF patients.

  5. Prospective study of the effects of ventilation tubes on hearing after radiotherapy for carcinoma of nasopharynx

    Energy Technology Data Exchange (ETDEWEB)

    Chowdhury, C.R.; Ho, J.H.; Wright, A.; Tsao, S.Y.; Au, G.K.; Tung, Y.

    1988-03-01

    In patients with nasopharyngeal carcinoma, deafness sometimes occurs following radiotherapy. It is usually conductive, but may be sensorineural. Tinnitus is present frequently and usually is distressing. The role of ventilation tubes (grommets) in relieving these problems was assessed in a prospective randomized controlled trial of 115 patients. In the group with grommets, there was an improvement in hearing, with a reduction of the averaged air-bone gap (p less than .01). This was not found in the control group without ventilation tubes, who developed a larger conductive loss (p less than .01) and, in addition, a slight deterioration of the averaged bone conduction threshold (p less than .01). Surprisingly, the group with grommets did not develop this sensorineural loss (p less than .01). In addition, tinnitus was improved significantly by the insertion of ventilation tubes (p less than .01). Neither necrosis nor stenosis of the external auditory meatus was found in either group.

  6. Help with Hearing

    Science.gov (United States)

    ... hearing. This problem can make it more diffi- cult to learn speech sounds and language correctly. Take ... how your child is hearing. See how diffi- cult it is to hear words correctly? Some children ...

  7. Protecting Your Hearing

    Medline Plus

    Full Text Available ... noise. [loud electric motors] A. Julianna Gulya, M.D.: Loud noise is an important cause of hearing ... has affected your hearing? A. Julianna Gulya, M.D.: Well, the hearing loss that's just occurred very ...

  8. Protecting Your Hearing

    Science.gov (United States)

    ... everywhere. But how do you know if loud noise has affected your hearing? A. Julianna Gulya, M.D.: Well, the hearing loss that's just occurred very rapidly -- sometimes like a sudden hearing loss, when you've been ...

  9. Measurements on Hearing

    DEFF Research Database (Denmark)

    Poulsen, Torben

    1996-01-01

    Background material for measurements of hearing for grammar school pupils. The note gives the necessary background for the exercise 'Measurement on Hearing'. The topics comprise sound and decibel, the ear, basic psychoacoustics, hearing threshold, audiometric measurement methods, speech and speech...

  10. Protecting Your Hearing

    Medline Plus

    Full Text Available ... affected your hearing? A. Julianna Gulya, M.D.: Well, the hearing loss that's just occurred very rapidly -- ... not that lucky and that hearing loss may be permanent. Narrator: There are two general types of ...

  11. How to Get Hearing Aids

    Science.gov (United States)

    ... Consumer Products Hearing Aids How to get Hearing Aids Share Tweet Linkedin Pin it More sharing options ... my hearing aids? How do I get hearing aids? To get hearing aids, you should first have ...

  12. Assesment of Hearing Loss in Patients with Psoriasis

    Directory of Open Access Journals (Sweden)

    Serdar Cenk Güvenç

    2012-03-01

    Full Text Available Background and Design: Psoriasis is an autoimmune chronic inflammatory skin disease characterized by T-cell mediated hyperproliferation of keratinocytes. Sensorineural hearing loss accompanied by autoimmune diseases was first described by McCabe in 1979. Cases of hearing loss associated with various autoimmune diseases have been reported. However, the number of studies evaluating the hearing loss in patients with psoriasis is insufficient. In this study, we aimed to assess hearing loss in psoriasis patients. Material and Methods: Fifty-one psoriasis patients, who were admitted to our outpatient clinic in 2010, and 51 healthy volunteers were included in the study. All participants underwent a complete ear, nose and throat examination before audiological assessment followed by, pure-tone audiometry in a sound-isolated audiology laboratory. Statistical analysis was performed using PASW Statistics version 18.0.0. A p-value less than 0.05 was considered statistically significant. Results: The mean bone and hearing thresholds were higher for all frequencies in patients than in controls. The values reached statistical significance at all frequencies except for right ear air conduction at 1000 Hz, bone conduction at 500 and 1000 Hz, left ear air conduction at 500 Hz, and bone conduction at 500 Hz (p<0.05. We compared the Psoriasis Area and Severity Index (PASI scores adjusted for age and disease duration and thresholds matched with frequencies and found a significant correlation between PASI score and hearing loss at medium and high frequencies. Conclusion: In psoriasis, chronic inflammation is thought to be the main pathological process destroying structure and functions of skin, nails and joints. We think that the same process may affect the cochlea in a similar way. The correlation between high PASI scores and hearing loss at medium and high frequencies may be an unexpected result of increased inflammatory mediators responsible from the disease in

  13. The development and standardization of Self-assessment for Hearing Screening of the Elderly

    Directory of Open Access Journals (Sweden)

    Kim G

    2016-06-01

    Full Text Available Gibbeum Kim,1 Wondo Na,1 Gungu Kim,1 Woojae Han,2 Jinsook Kim2 1Department of Speech Pathology and Audiology, Hallym University Graduate School, Chuncheon, Republic of Korea; 2Division of Speech Pathology and Audiology, Research Institute of Audiology and Speech Pathology, College of Natural Sciences, Hallym Universtiy, Chuncheon, Republic of Korea Purpose: The present study aimed to develop and standardize a screening tool for elderly people who wish to check for themselves their level of hearing loss. Methods: The Self-assessment for Hearing Screening of the Elderly (SHSE consisted of 20 questions based on the characteristics of presbycusis using a five-point scale: seven questions covered general issues related to sensorineural hearing loss, seven covered hearing difficulty under distracting listening conditions, two covered hearing difficulty with fast-rated speech, and four covered the working memory function during communication. To standardize SHSE, 83 elderly participants took part in the study: 25 with normal hearing, and 22, 23, and 13 with mild, moderate, and moderate-to-severe sensorineural hearing loss, respectively, according to their hearing sensitivity. All were retested 3 weeks later using the same questionnaire to confirm its reliability. In addition, validity was assessed using various hearing tests such as a sentence test with background noise, a time-compressed speech test, and a digit span test. Results: SHSE and its subcategories showed good internal consistency. SHSE and its subcategories demonstrated high test–retest reliability. A high correlation was observed between the total scores and pure-tone thresholds, which indicated gradually increased SHSE scores of 42.24%, 55.27%, 66.61%, and 78.15% for normal hearing, mild, moderate, and moderate-to-severe groups, respectively. With regard to construct validity, SHSE showed a high negative correlation with speech perception scores in noise and a moderate negative

  14. 21 CFR 801.420 - Hearing aid devices; professional and patient labeling.

    Science.gov (United States)

    2010-04-01

    ... rapidly progressive hearing loss within the previous 90 days. (iv) Acute or chronic dizziness. (v) Unilateral hearing loss of sudden or recent onset within the previous 90 days. (vi) Audiometric air-bone gap... special training to diagnose and treat hearing loss. Such physicians are also known as...

  15. The relationship of speech intelligibility with hearing sensitivity, cognition, and perceived hearing difficulties varies for different speech perception tests.

    Science.gov (United States)

    Heinrich, Antje; Henshaw, Helen; Ferguson, Melanie A

    2015-01-01

    Listeners vary in their ability to understand speech in noisy environments. Hearing sensitivity, as measured by pure-tone audiometry, can only partly explain these results, and cognition has emerged as another key concept. Although cognition relates to speech perception, the exact nature of the relationship remains to be fully understood. This study investigates how different aspects of cognition, particularly working memory and attention, relate to speech intelligibility for various tests. Perceptual accuracy of speech perception represents just one aspect of functioning in a listening environment. Activity and participation limits imposed by hearing loss, in addition to the demands of a listening environment, are also important and may be better captured by self-report questionnaires. Understanding how speech perception relates to self-reported aspects of listening forms the second focus of the study. Forty-four listeners aged between 50 and 74 years with mild sensorineural hearing loss were tested on speech perception tests differing in complexity from low (phoneme discrimination in quiet), to medium (digit triplet perception in speech-shaped noise) to high (sentence perception in modulated noise); cognitive tests of attention, memory, and non-verbal intelligence quotient; and self-report questionnaires of general health-related and hearing-specific quality of life. Hearing sensitivity and cognition related to intelligibility differently depending on the speech test: neither was important for phoneme discrimination, hearing sensitivity alone was important for digit triplet perception, and hearing and cognition together played a role in sentence perception. Self-reported aspects of auditory functioning were correlated with speech intelligibility to different degrees, with digit triplets in noise showing the richest pattern. The results suggest that intelligibility tests can vary in their auditory and cognitive demands and their sensitivity to the challenges that

  16. Dynamic Relation Between Working Memory Capacity and Speech Recognition in Noise During the First 6 Months of Hearing Aid Use

    Directory of Open Access Journals (Sweden)

    Elaine H. N. Ng

    2014-11-01

    Full Text Available The present study aimed to investigate the changing relationship between aided speech recognition and cognitive function during the first 6 months of hearing aid use. Twenty-seven first-time hearing aid users with symmetrical mild to moderate sensorineural hearing loss were recruited. Aided speech recognition thresholds in noise were obtained in the hearing aid fitting session as well as at 3 and 6 months postfitting. Cognitive abilities were assessed using a reading span test, which is a measure of working memory capacity, and a cognitive test battery. Results showed a significant correlation between reading span and speech reception threshold during the hearing aid fitting session. This relation was significantly weakened over the first 6 months of hearing aid use. Multiple regression analysis showed that reading span was the main predictor of speech recognition thresholds in noise when hearing aids were first fitted, but that the pure-tone average hearing threshold was the main predictor 6 months later. One way of explaining the results is that working memory capacity plays a more important role in speech recognition in noise initially rather than after 6 months of use. We propose that new hearing aid users engage working memory capacity to recognize unfamiliar processed speech signals because the phonological form of these signals cannot be automatically matched to phonological representations in long-term memory. As familiarization proceeds, the mismatch effect is alleviated, and the engagement of working memory capacity is reduced.

  17. Prevalence of hearing impairement in the district of Lucknow, India

    Directory of Open Access Journals (Sweden)

    Anupam Mishra

    2011-01-01

    Full Text Available A multi-cluster study (survey was carried out by department of ENT KG Medical University, Lucknow from July 2003 to August 2004 in rural and urban population of Lucknow district to estimate prevalence and causes of hearing impairment in the community. Data included audiological profile and basic ear examination that was analysed through EARFORM software program of WHO. Overall hearing impairment was seen in 15.14% of rural as opposed to 5.9% of urban population. A higher prevalence of disabling hearing impairment (DHI in elderly and deafness in 0-10 years age group was seen. The prevalence of sensorineural deafness necessitating hearing aids was 20% in rural and 50% in urban areas respectively. The presence of DHI was seen in 1/2 urban subjects and 1/3rd of rural counterparts. The incidence of cerumen / debris was very common in both types of population and the need of surgery was much more amongst rural subjects indicating more advanced / dangerous ear disease.

  18. Transplantation and survival of mouse inner ear progenitor/stem cells in the organ of Corti after cochleostomy of hearing-impaired guinea pigs: preliminary results

    OpenAIRE

    L.C.M. Barboza Jr.; K. Lezirovitz; Zanatta, D.B.; B.E. Strauss; Mingroni-Netto, R.C.; J. Oiticica; Haddad, L.A.; Bento, R.F.

    2016-01-01

    In mammals, damage to sensory receptor cells (hair cells) of the inner ear results in permanent sensorineural hearing loss. Here, we investigated whether postnatal mouse inner ear progenitor/stem cells (mIESCs) are viable after transplantation into the basal turns of neomycin-injured guinea pig cochleas. We also examined the effects of mIESC transplantation on auditory functions. Eight adult female Cavia porcellus guinea pigs (250-350g) were deafened by intratympanic neomycin delivery. After ...

  19. Phenotypic and genetic characterization of a family carrying two Xq21.1-21.3 interstitial deletions associated with syndromic hearing loss

    OpenAIRE

    Iossa, Sandra; Costa, Valerio; Corvino, Virginia; Auletta, Gennaro; Barruffo, Luigi; Cappellani, Stefania; Ceglia, Carlo; Cennamo, Giovanni; d’Adamo, Adamo Pio; D’Amico, Alessandra; Di Paolo, Nilde; Forte, Raimondo; Gasparini, Paolo; Laria, Carla; Lombardo, Barbara

    2015-01-01

    Background Sensorineural hearing impairment is a common pathological manifestation in patients affected by X-linked intellectual disability. A few cases of interstitial deletions at Xq21 with several different phenotypic characteristics have been described, but to date, a complete molecular characterization of the deletions harboring disease-causing genes is still missing. Thus, the aim of this study is to realize a detailed clinical and molecular analysis of a family affected by syndromic X-...

  20. Sensorineural deafness, abnormal genitalia, synostosis of metacarpals and metatarsals 4 and 5, and mental retardation

    DEFF Research Database (Denmark)

    Mendioroz, Jacobo; Fernández-Toral, Joaquín; Suárez, Etelvina;

    2005-01-01

    In 1988 Pfeiffer and Kapferer reported on a patient with sensorineural deafness, psychomotor delay, hypospadias, cerebral manifestations, and bilateral synostosis of the 4th and 5th metacarpals and metatarsals. Synostosis of the 4th and 5th metacarpals and metatarsals is a very rare defect that has...

  1. CERN hearing day

    CERN Multimedia

    2005-01-01

    1 in 10 people suffer from hearing loss ? do you? The Medical Service invites everyone working on the CERN site to participate in the NATIONAL HEARING DAY on: Thursday 10th March 2005 From 9am to 4pm The Infirmary, Blg. 57, Ground Floor We will be offering hearing tests (audiograms), as well as information and advice on hearing loss, tinnitus, etc. Deafness does not just affect the elderly: in Europe, 50% of the hearing-impaired are under the age of 55. Exposure to excessive noise is one of the main reasons for hearing problems but prevention is possible. For example, hearing protection devices can prevent 80% of tinnitus cases.

  2. CERN hearing day

    CERN Multimedia

    2005-01-01

    1 in 10 people suffer from hearing loss - do you? The Medical Service invites everyone working on the CERN site to participate in the NATIONAL HEARING DAY on: Thursday 10th March 2005 From 9am to 4pm The Infirmary, Blg. 57, Ground Floor We will be offering hearing tests (audiograms), as well as information and advice on hearing loss, tinnitus, etc. Deafness does not just affect the elderly: in Europe, 50% of the hearing-impaired are under the age of 55. Exposure to excessive noise is one of the main reasons for hearing problems but PREVENTION IS POSSIBLE. For example, hearing protection devices can prevent 80% of tinnitus cases.

  3. CERN hearing day

    CERN Document Server

    2005-01-01

    1 in 10 people suffer from hearing loss - do you? The Medical Service invites everyone working on CERN premises to participate in the National Hearing Day on: Thursday 10th March From 9am to 4pm The Infirmary, Blg. 57, Gr.Fl. We will be offering hearing tests (audiogram); information, advice on hearing loss, tinnitus and more. Deafness does not just affect the elderly: in Europe, 50% the hearing-impaired are under the age of 55. Exposure to excessive noise is one of the main reasons for hearing loss. But prevention is possible and effective: for example, Hearing protection devices could reduce tinnitus cases by 80%.

  4. CERN hearing day

    CERN Document Server

    2005-01-01

    1 in 10 people suffer from hearing loss - do you? The Medical Service invites everyone working on CERN premises to participate in the National Hearing Day on: Thursday 10th March From 9am to 4pm The Infirmary, Blg. 57, Gr.Fl. We will be offering hearing tests (audiogram); information, advice on hearing loss, tinnitus and more. Deafness does not just affect the elderly: in Europe, 50% the hearing-impaired are under the age of 55. Exposure to excessive noise is one of the main reasons for hearing loss. But PREVENTION IS POSSIBLE AND EFFECTIVE: for example, Hearing protection devices could reduce tinnitus cases by 80%.

  5. Could Neonatal Hypernatremia Dehydration Influence Hearing Status?

    Directory of Open Access Journals (Sweden)

    Hassan Boskabadi

    2014-01-01

    Full Text Available Introduction: Neonatal hypernatremia dehydration (NHD is a dangerous condition in neonates, which is accompanied by acute complications (renal failure, cerebral edema, and cerebral hemorrhage and chronic complications (developmental delay. Children begin learning language from birth, and hearing impairment interferes with this process. We assessed the hearing status of infants with hypernatremia dehydration.   Materials and Methods: In a case-control study in 110 infants presenting at the Ghaem Hospital (Mashhad, Iran between 2007 and 2011, we examined the incidence of hearing impairment in infants suffering from hypernatremia dehydration (serum sodium >150 mEq/L in comparison with infants with normal sodium level (serum sodium ≤150 mEq/L.   Results: Three of 110 cases examined in the study group showed a transient hearing impairment. A mean serum sodium level of 173mg/dl was reported among hearing-impaired infants.   Conclusion:  Transient hearing impairment was higher in infants with hypernatremia; although this difference was not significant (P>0.05. Hearing impairment was observed in cases of severe hypernatremia.