Sample records for acute salinity challenges

  1. The effects of acute salinity challenges on osmoregulation in Mozambique tilapia reared in a tidally changing salinity. (United States)

    Moorman, Benjamin P; Lerner, Darren T; Grau, E Gordon; Seale, Andre P


    This study characterizes the differences in osmoregulatory capacity among Mozambique tilapia, Oreochromis mossambicus, reared in freshwater (FW), in seawater (SW) or under tidally driven changes in salinity. This was addressed through the use of an abrupt exposure to a change in salinity. We measured changes in: (1) plasma osmolality and prolactin (PRL) levels; (2) pituitary expression of prolactin (PRL) and its receptors, PRLR1 and PRLR2; (3) branchial expression of PRLR1, PRLR2, Na(+)/Cl(-) co-transporter (NCC), Na(+)/K(+)/2Cl(-) co-transporter (NKCC), α1a and α1b isoforms of Na(+)/K(+)-ATPase (NKA), cystic fibrosis transmembrane conductance regulator (CFTR), aquaporin 3 (AQP3) and Na(+)/H(+) exchanger 3 (NHE3). Mozambique tilapia reared in a tidal environment successfully adapted to SW while fish reared in FW did not survive a transfer to SW beyond the 6 h sampling. With the exception of CFTR, the change in the expression of ion pumps, transporters and channels was more gradual in fish transferred from tidally changing salinities to SW than in fish transferred from FW to SW. Upon transfer to SW, the increase in CFTR expression was more robust in tidal fish than in FW fish. Tidal and SW fish successfully adapted when transferred to FW. These results suggest that Mozambique tilapia reared in a tidally changing salinity, a condition that more closely represents their natural history, gain an adaptive advantage compared with fish reared in FW when facing a hyperosmotic challenge.

  2. Sea Surface Salinity : Research Challenges and Opportunities (United States)

    Halpern, David; Lagerloef, Gary; Font, Jordi


    Sea surface salinity (SSS) can be important in regulating sea surface temperature (SST). Two technological breakthrough satellite SSS missions, Aquarius and Soil Moisture and Ocean Salinity (SMOS), are currently producing high-quality SSS data. This paper provides an overview of the importance of SSS for weather and climate applications and describes the Aquarius and SMOS missions. The newness of adequately sampled SSS data prompted a first-time at-sea field campaign devoted to improved understanding of SSS variations.

  3. Improvement of Salinity Stress Tolerance in Rice: Challenges and Opportunities

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    Thi My Linh Hoang


    Full Text Available Rice (Oryza sativa L. is an important staple crop that feeds more than one half of the world’s population and is the model system for monocotyledonous plants. However, rice is very sensitive to salinity and is the most salt sensitive cereal crop with a threshold of 3 dSm−1 for most cultivated varieties. Despite many attempts using different strategies to improve salinity tolerance in rice, the achievements so far are quite modest. This review aims to discuss challenges that hinder the improvement of salinity stress tolerance in rice as well as potential opportunities for enhancing salinity stress tolerance in this important crop.

  4. Normal Saline Versus Hypertonic 3% Saline: It’s Efficacy in Non-Acute Rhinosinusitis

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    Nezamoddin Berjis


    Full Text Available Introduction: Sinusitis is one of the most common diseases in general and in otolaryngology practice, but the optimal therapeutic options have not yet been fully developed. This manuscript will try to compare normal saline nasal douching with hypertonic saline in reducing symptoms and improving its signs. Materials and Methods: One hundred and fourteen patients suffering from non acute rhinosinusitis, documented by history, physical examination and radiologic studies were divided into normal saline and hypertonic saline groups, each consisting of 57 patients. data were obtained by physical examination and a questionnaire.. Results:  Type of treatment had no significant effect on headache, morning dryness of mouth and pharynx and fatigue. Nontheless, nasal congestion, purulent discharge and postnasal discharge were reported to have improved in the group treated with hypertonic saline versus the normal saline group. Patient satisfaction also showed better scores in the hypertonic saline group. Conclusion: Hypertonic saline (3% is more effective for nasal irrigation  than normal saline in chronic rhinosinusitis.

  5. Challenges in uncomplicated acute appendicitis

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    Fernando Resende; Ana Beatriz Almeida; Jose Costa Maia; Renato Bessa Melo


    Acute appendicitis is one of the most common abdominal emergencies requiring surgery. It still represents, however, a challenging diagnosis. In order to facilitate this process, several scoring systems were developed, namely, the Alvarado score, acute inflammatory response and Raja Isteri Pengiran Anak Saleha Appendicitis scores, which are the most used in clinical practice. This clinical condition encompasses a wide spectrum of clinical presentations, from the uncomplicated form to the one with diffuse peritonitis. Treatment of uncomplicated acute appendicitis remains a matter of discussion. Although appen-dectomy has been regarded as the gold-standard, conservative management with antibi-otics is gaining more and more acceptance. The approach to appendectomy constitutes another controversial issue, namely, its performance through an open or a laparoscopic approach, which seems to be establishing itself, in some centers, as the standard of care. With this paper, we intend to give some insight on the aforementioned topics, through a review of the available literature on uncomplicated appendicitis.

  6. Hypertonic saline challenge in an adult epidemiological survey. (United States)

    Rabone, S J; Phoon, W O; Anderson, S D; Wan, K C; Seneviratne, M; Gutierrez, L; Brannan, J


    Bronchial provocation tests using pharmacological agents such as methacholine or histamine are used in epidemiological studies to identify asthma despite recognition of limitations in specificity, positive predictive value and availability of reagents. Hypertonic saline (4.5%) bronchial challenge (HSBC), although less sensitive than pharmacological challenges, is reportedly highly specific in diagnosing current asthma. Added advantages are that reagents are cheap, stable and recognized by participants. Thus, HSBC may offer benefits over pharmacological tests in epidemiological surveys. This paper reports on the second field survey using the test, a study of 99 adults from the timber industry in Western Australia. The test is described and critically appraised as a practical epidemiological tool for assessing asthma prevalence. At a cutoff point of 20% FEV, fall, HSBC was positive in 8% of subjects, appeared specific for asthma, was safe, well-accepted and easy to use in the field.

  7. Aerosolised hypertonic saline in hospitalized young children with acute bronchiolitis: a randomized controlled clinical trial.


    Maheshkumar, K B; B.P. Karunakara; Nagalli, Manjunath Mallikarjuna; Mallikarjuna, H B


    ABSTRACT: Objectives: To determine the effectiveness of aerosolised 3% saline in hospitalised children with acute bronchiolitis. Design: Prospective, randomized, double blinded clinical study. Setting: Referral teaching hospital, from October 2007 to March 2009. Patients: 40 children [age less than 2 yrs] were enrolled sequentially and randomized into 2 groups [20 each; Group- A - 3% saline and Group-B [Normal saline]. Intervention: 4 nebulizations [3% saline or normal s...

  8. Saturated hydrogen saline attenuates endotoxin-induced acute liver dysfunction in rats. (United States)

    Xu, X-F; Zhang, J


    To determine the effect of saturated hydrogen saline on lipopolysaccharide (LPS)-induced acute liver dysfunction, rats were divided into control, LPS, and LPS plus saturated hydrogen saline (LPS+H(2)) groups. Treatment with saturated hydrogen saline prolonged the median survival time and reduced liver dysfunction. Moreover, saturated hydrogen saline significantly reduced pathological alterations in liver tissues, the number of ballooned hepatocytes, serum tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 levels, and myeloperoxidase (MPO) and malondialdehyde (MDA) levels in liver tissues (Phydrogen saline treatment. Saturated hydrogen saline also decreased phosphorylated extracellular signal-regulated kinase (p-ERK), phosphorylated Jun kinase (p-JNK), nuclear factor-kappa B (NF-kappaB), and second mitochondria-derived activator of caspase (Smac) levels, and increased p38 activation (Phydrogen saline may attenuate LPS-induced acute liver dysfunction in rats, possibly by reducing inflammation and cell apoptosis. Mitogen-activated protein kinase (MAPK), NF-kappaB, and Smac may contribute to saturated hydrogen saline-mediated liver protection.

  9. Nebulized Isotonic Saline versus Water following a Laryngeal Desiccation Challenge in Classically Trained Sopranos (United States)

    Tanner, Kristine; Roy, Nelson; Merrill, Ray M.; Muntz, Faye; Houtz, Daniel R.; Sauder, Cara; Elstad, Mark; Wright-Costa, Julie


    Purpose: To examine the effects of nebulized isotonic saline (IS) versus sterile water (SW) on self-perceived phonatory effort (PPE) and phonation threshold pressure (PTP) following a surface laryngeal dehydration challenge in classically trained sopranos. Method: In a double-blind, within-subject crossover design, 34 sopranos breathed dry air…

  10. Emergency anesthesia for evacuating a traumatic acute subdural hemorrhage in a child overdosed with hypertonic saline

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    Chulananda Goonasekera


    Full Text Available A previously healthy 1-year-old child with a traumatic acute subdural hemorrhage received 10 times higher dose of hypertonic saline inadvertently immediately before surgery. This case report describes deviations in fluid management needed to alleviate salt toxicity and its adverse effects during surgery under anesthesia perioperatively. The child made an uneventful recovery with no evident residual damage at follow-up.

  11. Acute hepatitis C: Prospects and challenges

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    More than 170 million people worldwide have chronic hepatitis C. Acute hepatitis C is rarely diagnosed because it is commonly asymptomatic. Most infected patients are unaware of their condition until the symptoms of chronic infection manifest. Treatment of acute hepatitis C is something of a paradox because spontaneous resolution is possible and many patients do not have symptoms.However, several factors provide a rationale for treating patients who have acute hepatitis C. Compared with acute hepatitis C, chronic hepatitis C is associated with a worse prognosis, the need for more intensive treatment,longer treatment duration, and a decrease in successful treatment outcomes. Conversely, early intervention is associated with improved viral eradication, using a regimen that is better tolerated, less expensive, more convenient, and of shorter duration than the currently approved combination therapies for chronic hepatitis C.

  12. Effect of saline loading on uranium-induced acute renal failure in rats

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    Hishida, A.; Yonemura, K.; Ohishi, K.; Yamada, M.; Honda, N.


    Studies were performed to examine the effect of saline loading on uranium-induced acute renal failure (ARF) in rats. Forty-eight hours after the i.v. injection of uranyl acetate (UA, 5 mg/kg), inulin clearance rate (Cin) decreased to approximately 43% of the control value in water drinking rats (P less than 0.005). Animals receiving continuous isotonic saline infusion following UA showed higher urine flow and Cin (60% of control, P less than 0.01), and lessened intratubular cast formation when compared with water-drinking ARF rats. A short-term saline infusion following UA did not attenuate the decline in Cin (43% of control). An inverse relationship was found between Cin and the number of casts (r = -0.75, P less than 0.01). Multiple regression analysis showed that standardized partial regression coefficient is statistically significant between Cin and cast formation (-0.69, P less than 0.05), but not between Cin and tubular necrosis (-0.07, P greater than 0.05). Renin depletion caused by DOCA plus saline drinking did not attenuate the decline in Cin in ARF (47% of control). No significant difference was found in urinary uranium excretion between water-drinking and saline-infused ARF rats. The findings suggest that continuous saline infusion following UA attenuates the decline in Cin in ARF rats; and that this beneficial effect of saline loading is associated with lessened cast formation rather than with suppressed renin-angiotensin activity or enhanced urinary-uranium excretion.

  13. Hydrogen-Rich Saline Attenuates Acute Renal Injury in Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting ROS and NF-κB Pathway


    Qiao Shi; Kang-Shu Liao; Kai-Liang Zhao; Wei-Xing Wang; Teng Zuo; Wen-Hong Deng; Chen Chen; Jia Yu; Wen-Yi Guo; Xiao-Bo He; Ablikim Abliz; Peng Wang; Liang Zhao


    Hydrogen (H2), a new antioxidant, was reported to reduce •OH and ONOO− selectively and inhibit certain proinflammatory mediators to product, without disturbing metabolic redox reactions or ROS involved in cell signaling. We herein aim to explore its protective effects on acute renal injury in sodium taurocholate-induced acute pancreatitis and its possible mechanisms. Rats were injected with hydrogen-rich saline (HRS group) or normal saline (SO and SAP group) through tail intravenously (6 mL/k...

  14. Acute extracellular fluid volume changes increase ileocolonic resistance to saline flow in anesthetized dogs

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    Santiago Jr. A.T.


    Full Text Available We determined the effect of acute extracellular fluid volume changes on saline flow through 4 gut segments (ileocolonic, ileal, ileocolonic sphincter and proximal colon, perfused at constant pressure in anesthetized dogs. Two different experimental protocols were used: hypervolemia (iv saline infusion, 0.9% NaCl, 20 ml/min, volume up to 5% body weight and controlled hemorrhage (up to a 50% drop in mean arterial pressure. Mean ileocolonic flow (N = 6 was gradually and significantly decreased during the expansion (17.1%, P<0.05 and expanded (44.9%, P<0.05 periods while mean ileal flow (N = 7 was significantly decreased only during the expanded period (38%, P<0.05. Mean colonic flow (N = 7 was decreased during expansion (12%, P<0.05 but returned to control levels during the expanded period. Mean ileocolonic sphincter flow (N = 6 was not significantly modified. Mean ileocolonic flow (N = 10 was also decreased after hemorrhage (retracted period by 17% (P<0.05, but saline flow was not modified in the other separate circuits (N = 6, 5 and 4 for ileal, ileocolonic sphincter and colonic groups, respectively. The expansion effect was blocked by atropine (0.5 mg/kg, iv both on the ileocolonic (N = 6 and ileal (N = 5 circuits. Acute extracellular fluid volume retraction and expansion increased the lower gastrointestinal resistances to saline flow. These effects, which could physiologically decrease the liquid volume being supplied to the colon, are possible mechanisms activated to acutely balance liquid volume deficit and excess.

  15. Hydrogen-rich saline attenuates acute renal injury in sodium taurocholate-induced severe acute pancreatitis by inhibiting ROS and NF-κB pathway. (United States)

    Shi, Qiao; Liao, Kang-Shu; Zhao, Kai-Liang; Wang, Wei-Xing; Zuo, Teng; Deng, Wen-Hong; Chen, Chen; Yu, Jia; Guo, Wen-Yi; He, Xiao-Bo; Abliz, Ablikim; Wang, Peng; Zhao, Liang


    Hydrogen (H2), a new antioxidant, was reported to reduce (•)OH and ONOO(-) selectively and inhibit certain proinflammatory mediators to product, without disturbing metabolic redox reactions or ROS involved in cell signaling. We herein aim to explore its protective effects on acute renal injury in sodium taurocholate-induced acute pancreatitis and its possible mechanisms. Rats were injected with hydrogen-rich saline (HRS group) or normal saline (SO and SAP group) through tail intravenously (6 mL/kg) and compensated subcutaneously (20 mL/kg) after successful modeling. Results showed that hydrogen-rich saline attenuated the following: (1) serum Cr and BUN, (2) pancreatic and renal pathological injuries, (3) renal MDA, (4) renal MPO, (5) serum IL-1β, IL-6, and renal TNF-α, HMGB1, and (6) tyrosine nitration, IκB degradation, and NF-κB activation in renal tissues. In addition, it increased the level of IL-10 and SOD activity in renal tissues. These results proved that hydrogen-rich saline attenuates acute renal injury in sodium taurocholate-induced acute pancreatitis, presumably because of its detoxification activity against excessive ROS, and inhibits the activation of NF-κB by affecting IκB nitration and degradation. Our findings highlight the potential value of hydrogen-rich saline as a new therapeutic method on acute renal injury in severe acute pancreatitis clinically.

  16. Hydrogen-rich saline ameliorates the severity of L-arginine-induced acute pancreatitis in rats

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    Chen, Han; Sun, Yan Ping; Li, Yang [Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai 200003 (China); Liu, Wen Wu [Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433 (China); Xiang, Hong Gang [Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai 200003 (China); Fan, Lie Ying [Department of Clinical Laboratory, Shanghai East Hospital, Tong Ji University, Shanghai 200120 (China); Sun, Qiang [Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433 (China); Xu, Xin Yun [Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai 200003 (China); Cai, Jian Mei [Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433 (China); Ruan, Can Ping; Su, Ning; Yan, Rong Lin [Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai 200003 (China); Sun, Xue Jun, E-mail: [Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433 (China); Wang, Qiang, E-mail: [Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai 200003 (China)


    Molecular hydrogen, which reacts with the hydroxyl radical, has been considered as a novel antioxidant. Here, we evaluated the protective effects of hydrogen-rich saline on the L-arginine (L-Arg)-induced acute pancreatitis (AP). AP was induced in Sprague-Dawley rats by giving two intraperitoneal injections of L-Arg, each at concentrations of 250 mg/100 g body weight, with an interval of 1 h. Hydrogen-rich saline (>0.6 mM, 6 ml/kg) or saline (6 ml/kg) was administered, respectively, via tail vein 15 min after each L-Arg administration. Severity of AP was assessed by analysis of serum amylase activity, pancreatic water content and histology. Samples of pancreas were taken for measuring malondialdehyde and myeloperoxidase. Apoptosis in pancreatic acinar cell was determined with terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling technique (TUNEL). Expression of proliferating cell nuclear antigen (PCNA) and nuclear factor kappa B (NF-{kappa}B) were detected with immunohistochemistry. Hydrogen-rich saline treatment significantly attenuated the severity of L-Arg-induced AP by ameliorating the increased serum amylase activity, inhibiting neutrophil infiltration, lipid oxidation and pancreatic tissue edema. Moreover, hydrogen-rich saline treatment could promote acinar cell proliferation, inhibit apoptosis and NF-{kappa}B activation. These results indicate that hydrogen treatment has a protective effect against AP, and the effect is possibly due to its ability to inhibit oxidative stress, apoptosis, NF-{kappa}B activation and to promote acinar cell proliferation.

  17. [Nebulized hypertonic saline and acute viral bronchiolitis in infants: current aspects]. (United States)

    Sauvaget, E; David, M; Bresson, V; Retornaz, K; Bosdure, E; Dubus, J-C


    Acute viral bronchiolitis affects infants, is frequent, and can be severe. Its treatment is only based on symptoms. Hypertonic saline (HS) may act favorably in this situation by fighting virus-induced dehydration of the airway liquid surface. Because of an osmotic action, HS attracts the water from the epithelial cells and improves mucociliary clearance. Five double-blind placebo-controlled studies concerning hospitalized infants with acute viral bronchiolitis showed that repeated nebulizations of 3% HS induce a 20% improvement in the clinical severity score and reduced the hospital length of stay by 24h. Tolerance is excellent. On the other hand, a few questions remain unresolved: what is the optimal salt concentration? What is the recommended nebulizer? What is the best frequency for nebulizer use? Can nebulized HS be used at home? What are the results with systematic physiotherapy when HS is used?


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    Full Text Available AIMS AND OBJECTIVES: To compare the effects of nebulised 3% hypertonic saline , 0.9% saline and salbutamol in patients of acute bronchiolitis . DESIGN: R andomised controlled trial . SETTING: tertiary care teaching hospital . MATERIAL AND METHODS: 100 Children with age 1 to 24 months admitted in hospital with clinical diagnosis of acute bronchiolitis for 2 consecutive years were included in the study. Participants were divided into 3 groups – 3% hypertonic saline (HS , 0.9% norm al saline and salbutalmol. 4 doses of nebulisation at an interval of 6 hours were given daily in each group till discharge. RESULTS: The mean age of the patients in the study population was 5.7 ± 3.4 months. Maximum number of the patients i.e. 65.7% belong ed to the age group of 0 - 6 months. There was male preponderance in all 3 groups. Baseline Clinical Severity (CS scores in 3%HS , 0.9% Normal Saline and Salbutamol groups were 5.9±1.5 , 5.5±1.0 and 5.1±2.3 respectively (p=0.146. After treatment , the CS scor es dropped to 1.0±1.1 , 3.3±0.5 and 1.9±1.1 in 3%HS , 0.9% Normal Saline and Salbutamol groups respectively on the 3 rd day of treatment (p<0.01. Length of hospital stay in 3% HS , 0.9% Normal Saline and Salbutamol groups was 3.4±1.7 , 4.9±1.4 and 3.7±1.9 days respectively , which was found to be statistically significant (p= 0.001. CONCLUSION: 3% Hypertonic Saline nebulization (without additional bronchodilators is an effective and safe treatment in patients of acute bronchiolitis. It significantly reduces th e CS scores and length of hospital stay as compared to 0.9% Normal Saline and Salbutamol nebulizations.

  19. Acute kidney injury in pregnancy: a clinical challenge. (United States)

    Machado, Susana; Figueiredo, Nuno; Borges, Andreia; São José Pais, Maria; Freitas, Luís; Moura, Paulo; Campos, Mário


    The incidence of acute kidney injury in pregnancy declined significantly over the second half of the 20th century; however, it is still associated with major maternal and perinatal morbidity and mortality. A set of systemic and renal physiological adaptive mechanisms occur during a normal gestation that will constrain several changes in laboratory parameters of renal function, electrolytes, fluid and acid-base balances. The diagnosis of acute kidney injury in pregnancy is based on the serum creatinine increase. The usual formulas for estimating glomerular filtration rate are not validated in this population. During the first trimester of gestation, acute kidney injury develops most often due to hyperemesis gravidarum or septic abortion. In the third trimester, the differential diagnosis is more challenging for the obstetrician and the nephrologist and comprises some pathologies that are reviewed in this article: preeclampsia/HELLP syndrome, acute fatty liver of pregnancy and thrombotic microangiopathies.

  20. An enriched environment reduces the stress level and locomotor activity induced by acute morphine treatment and by saline after chronic morphine treatment in mice. (United States)

    Xu, Jia; Sun, Jinling; Xue, Zhaoxia; Li, Xinwang


    This study investigated the relationships among an enriched environment, stress levels, and drug addiction. Mice were divided randomly into four treatment groups (n=12 each): enriched environment without restraint stress (EN), standard environment without restraint stress (SN), enriched environment with restraint stress (ES), and standard environment with restraint stress (SS). Mice were reared in the respective environment for 45 days. Then, the ES and SS groups were subjected to restraint stress daily (2 h/day) for 14 days, whereas the EN and SN groups were not subjected to restraint stress during this stage. The stress levels of all mice were tested in the elevated plus maze immediately after exposure to restraint stress. After the 2-week stress testing period, mice were administered acute or chronic morphine (5 mg/kg) treatment for 7 days. Then, after a 7-day withdrawal period, the mice were injected with saline (1 ml/kg) or morphine (5 mg/kg) daily for 2 days to observe locomotor activity. The results indicated that the enriched environment reduced the stress and locomotor activity induced by acute morphine administration or saline after chronic morphine treatment. However, the enriched environment did not significantly inhibit locomotor activity induced by morphine challenge. In addition, the stress level did not mediate the effect of the enriched environment on drug-induced locomotor activity after acute or chronic morphine treatment.

  1. Comparison of salbutamol with normal saline and salbutamol with magnesium sulphate in the treatment of severe acute asthma. (United States)

    Ahmed, S; Sutradhar, S R; Miah, A H; Bari, M A; Hasan, M J; Alam, M K; Tariquzzaman, M; Sarker, C N


    This study compared the efficacy and safety of nebulized magnesium sulphate with salbutamol to normal saline with salbutamol as the initial treatment of severe acute asthma patients. The present study was designed as a randomized open controlled clinical trial. The study was conducted Mymensingh Medical College Hospital over a period of 11 months from December 2009 to October 2010. Patients admitted with severe acute asthma having inclusion criteria were the study population. Among 120 study population 60 were in salbutamol with magnesium sulphate group and 60 were in salbutamol with normal saline group. The study finding showed that peak flow at baseline was similar in two groups. At 10 minutes after nebulization, the mean±SD percentage increase in peak flow was greater in magnesium sulphate group (20±4%) than in the normal saline salbutamol group (13±3%). At 20 minutes the percentage increase in peak flow was greater in magnesium sulphate group (35±7%) than in the normal saline salbutamol group (24±6%) p value salbutamol group reached PEF near to 60% which is not in saline salbutamol group. There was no significant changed in respiratory rate, pulse rate, systolic, diastolic blood pressure and clinical evidence of unwanted adverse effect.

  2. Effect of blood transfusion, dopamine, or normal saline on neurogenic shock secondary to acutely raised intracranial pressure. (United States)

    Rahimifar, M; Tator, C H; Shanlin, R J; Sole, M J


    An experimental model to simulate acutely raised intracranial pressure due to a rapidly expanding intracranial space-occupying lesion was used to produce neurogenic shock. Forty-one rats in neurogenic shock (defined as a mean systemic arterial pressure (SAP) of less than 60 mm Hg) were subjected to various treatments to increase the mean SAP to a level of more than 80 mm Hg. The control group with neurogenic shock received no treatment, and the six treatment groups received infusions of: whole blood, packed cells, plasma, normal saline, dopamine, or a combination of dopamine and saline. Detrimental effects were observed after transfusion of packed cells or whole blood, which caused further deterioration of mean SAP. Although dopamine or the combination of dopamine and saline were both effective (p = 0.0001) for reversing hypotension, the combination was the most effective. If this rat paradigm correlates with human disease, these results indicate that, in the absence of hypovolemia, neurogenic shock due to acute intracranial hypertension should be treated with a combined transfusion of dopamine and normal saline, but not blood since the latter could have a detrimental effect.

  3. Hydrogen-rich saline injection into the subarachnoid cavity within 2 weeks promotes recovery after acute spinal cord injur y

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    Jian-long Wang; Qing-shan Zhang; Kai-di Zhu; Jian-feng Sun; Ze-peng Zhang; Jian-wen Sun; Ke-xiang Zhang


    Hydrogen can relieve tissue-damaging oxidative stress, inlfammation and apoptosis. Injection of hydrogen-rich saline is an effective method for transporting molecular hydrogen. We hypothe-sized that hydrogen-rich saline would promote the repair of spinal cord injury induced by Allen’s method in rats. At 0.5, 1, 2, 4, 8, 12 and 24 hours after injury, then once daily for 2 weeks, 0.25 mL/kg hydrogen-rich saline was infused into the subarachnoid space through a catheter. Results at 24 hours, 48 hours, 1 week and 2 weeks after injury showed that hydrogen-rich saline marked-ly reduced cell death, inlfammatory cell inifltration, serum malondialdehyde content, and caspa se-3 immunoreactivity, elevated serum superoxide dismutase activity and calcitonin gene-related peptide immunoreactivity, and improved motor function in the hindlimb. The present study conifrms that hydrogen-rich saline injected within 2 weeks of injury effectively contributes to the repair of spinal cord injury in the acute stage.

  4. Hydrogen-rich saline injection into the subarachnoid cavity within 2 weeks promotes recovery after acute spinal cord injury

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    Jian-long Wang


    Full Text Available Hydrogen can relieve tissue-damaging oxidative stress, inflammation and apoptosis. Injection of hydrogen-rich saline is an effective method for transporting molecular hydrogen. We hypothesized that hydrogen-rich saline would promote the repair of spinal cord injury induced by Allen′s method in rats. At 0.5, 1, 2, 4, 8, 12 and 24 hours after injury, then once daily for 2 weeks, 0.25 mL/kg hydrogen-rich saline was infused into the subarachnoid space through a catheter. Results at 24 hours, 48 hours, 1 week and 2 weeks after injury showed that hydrogen-rich saline markedly reduced cell death, inflammatory cell infiltration, serum malondialdehyde content, and caspase-3 immunoreactivity, elevated serum superoxide dismutase activity and calcitonin gene-related peptide immunoreactivity, and improved motor function in the hindlimb. The present study confirms that hydrogen-rich saline injected within 2 weeks of injury effectively contributes to the repair of spinal cord injury in the acute stage.

  5. Influence factors of salt-sensitive hypertension and responses of blood pressure and urinary sodium and potassium excretion to acute oral saline loading among essential hypertensive patients

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    Objective To explore the influence factors of saltsensitive hypertension and to observe changes of blood pressures and urinary sodium and potassium excretion in response to acute oral saline loading among essential hypertensive patients in China.Methods Essential hypertensive patients from Beijing Jinzhan second community were included in this study.Salt-sensitivity was determined via the improved Sullivan’s acute oral saline loading

  6. Effectiveness of 3% hypertonic saline nebulization in acute bronchiolitis among Indian children: A quasi-experimental study

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    Harsh V Gupta


    Full Text Available Objective: To compare the effects of 3% hypertonic saline (HS and 0.9% normal saline with nebulized 0.9% normal saline with salbutamol in patients of acute viral bronchiolitis. Materials and Methods: Participants were divided into three groups, that is, 3% HS group, 0.9% normal saline group and 0.9% saline with salbutamol group. Four doses at interval of 6 h were given daily until discharge. Average CS score and length of hospital stay were compared. One-way analysis of variance paired t-test and Chi-square test were utilized for statistical analysis. Results: The mean ages of the patients in three groups were 6.03 ± 3.71, 5.69 ± 3.34 and 5.48 ± 3.35 respectively. The 3rd day CS scores for all the groups were 1.0 ± 1.1, 1.9 ± 1.1 and 3.3 ± 0.5 respectively (P = 0.000. The average length of hospital stay was 3.4 ± 1.7, 3.7 ± 1.9 and 4.9 ± 1.4 days respectively (P = 0.001. Conclusion: The present study concludes that 3% HS nebulization (without additional bronchodilators is an effective and safe treatment for nonasthmatic, moderately ill patients of acute bronchiolitis. The economic benefit of this comparably priced modality of treatment can be enormous in terms of hospital costs with parents returning to work sooner.

  7. Effectiveness of 3% hypertonic saline nebulization in acute bronchiolitis among Indian children: A quasi-experimental study (United States)

    Gupta, Harsh V.; Gupta, Vivek V.; Kaur, Gurmeet; Baidwan, Amitoz S.; George, Pardeep P.; Shah, Jay C.; Shinde, Kushal; Malik, Ruku; Chitkara, Neha; Bajaj, Krushnan V.


    Objective: To compare the effects of 3% hypertonic saline (HS) and 0.9% normal saline with nebulized 0.9% normal saline with salbutamol in patients of acute viral bronchiolitis. Materials and Methods: Participants were divided into three groups, that is, 3% HS group, 0.9% normal saline group and 0.9% saline with salbutamol group. Four doses at interval of 6 h were given daily until discharge. Average CS score and length of hospital stay were compared. One-way analysis of variance paired t-test and Chi-square test were utilized for statistical analysis. Results: The mean ages of the patients in three groups were 6.03 ± 3.71, 5.69 ± 3.34 and 5.48 ± 3.35 respectively. The 3rd day CS scores for all the groups were 1.0 ± 1.1, 1.9 ± 1.1 and 3.3 ± 0.5 respectively (P = 0.000). The average length of hospital stay was 3.4 ± 1.7, 3.7 ± 1.9 and 4.9 ± 1.4 days respectively (P = 0.001). Conclusion: The present study concludes that 3% HS nebulization (without additional bronchodilators) is an effective and safe treatment for nonasthmatic, moderately ill patients of acute bronchiolitis. The economic benefit of this comparably priced modality of treatment can be enormous in terms of hospital costs with parents returning to work sooner. PMID:27141475

  8. Challenges in the management of acute peptic ulcer bleeding. (United States)

    Lau, James Y W; Barkun, Alan; Fan, Dai-ming; Kuipers, Ernst J; Yang, Yun-sheng; Chan, Francis K L


    Acute upper gastrointestinal bleeding is a common medical emergency worldwide, a major cause of which are bleeding peptic ulcers. Endoscopic treatment and acid suppression with proton-pump inhibitors are cornerstones in the management of the disease, and both treatments have been shown to reduce mortality. The role of emergency surgery continues to diminish. In specialised centres, radiological intervention is increasingly used in patients with severe and recurrent bleeding who do not respond to endoscopic treatment. Despite these advances, mortality from the disorder has remained at around 10%. The disease often occurs in elderly patients with frequent comorbidities who use antiplatelet agents, non-steroidal anti-inflammatory drugs, and anticoagulants. The management of such patients, especially those at high cardiothrombotic risk who are on anticoagulants, is a challenge for clinicians. We summarise the published scientific literature about the management of patients with bleeding peptic ulcers, identify directions for future clinical research, and suggest how mortality can be reduced.

  9. Special nutrition challenges: current approach to acute kidney injury. (United States)

    McCarthy, Mary S; Phipps, Shauna C


    Acute kidney injury (AKI), previously known as acute renal failure, is defined as a sudden decline in glomerular filtration rate with accumulation of metabolic waste products, toxins, and drugs, as well as alteration in the intrinsic functions of the kidney. Reports of mortality are as high as 80%, with numerous contributing causes including infection, cardiorespiratory complications, and cardiovascular disease. Concurrent with the high prevalence of critical illness in this population is the protein energy wasting (PEW), seen in up to 42% of patients upon intensive care unit admission. The pathophysiologic derangements of critical illness, the low energy and protein stores, and uremic complications require early nutrition intervention to attenuate the inflammatory response and oxidative stress, improve endothelial function, stabilize blood sugar, and preserve lean body mass. This article addresses the unique challenges of nutrition support for the patient with AKI in the setting of critical illness and renal replacement therapy. Evidence-based recommendations are provided to meet the macronutrient and micronutrient requirements of this heterogeneous and complex patient population.

  10. Ionic and Amino Acid Regulation in Hard Clam (Meretrix lusoria in Response to Salinity Challenges

    Directory of Open Access Journals (Sweden)

    Chia-Hao Lin


    Full Text Available Most marine mollusks are osmoconformers, in that, their body fluid osmolality changes in the direction of the change in environmental salinity. Marine mollusks exhibit a number of osmoregulatory mechanisms to cope with either hypo- or hyperosmotic stress. The effects of changes in salinity on the osmoregulatory mechanisms of the hard clam (Meretrix lusoria, an economically important species of marine bivalve for Taiwan have not been determined. In this study, we examined the effect of exposure to hypo (10‰- and hyper (35‰-osmotic salinity on hard clams raised at their natural salinity (20‰. The osmolality, [Na+], and [Cl-] of the hard clam hemolymph were changed in the same direction as the surrounding salinity. Further, the contents of total free amino acids including taurine in the gills and mantles were significantly upregulated in hard clam with increasing salinity. The gill Na+,K+-ATPase (NKA activity, the important enzyme regulating cellular inorganic ions, was not affected by the changed salinity. Mantle NKA activity, however, was stimulated in the 35‰ SW treatment. The taurine transporter (TAUT is related to the regulation of intracellular contents of taurine, the dominant osmolyte. Herein, a TAUT gene of hard clam was cloned and a TAUT antibody was derived for the immunoblotting. The TAUT mRNA expression of the mantle in hard clam was significantly stimulated in 35‰ SW, but protein expression was not modulated by the changed salinity. In gills of the hard clam with 10‰ SW, both TAUT mRNA and protein expressions were significantly stimulated, and it may reflect a feedback regulation from the decreased gills taurine content under long-term hypoosmotic acclimation. These findings suggest that TAUT expression is regulated differently in gills and mantles following exposure to alterations in environmental salinity. Taken together, this study used the physiological, biochemical and molecular approaches to simultaneously explore

  11. Ionic and Amino Acid Regulation in Hard Clam (Meretrix lusoria) in Response to Salinity Challenges. (United States)

    Lin, Chia-Hao; Yeh, Po-Ling; Lee, Tsung-Han


    Most marine mollusks are osmoconformers, in that, their body fluid osmolality changes in the direction of the change in environmental salinity. Marine mollusks exhibit a number of osmoregulatory mechanisms to cope with either hypo- or hyperosmotic stress. The effects of changes in salinity on the osmoregulatory mechanisms of the hard clam (Meretrix lusoria, an economically important species of marine bivalve for Taiwan) have not been determined. In this study, we examined the effect of exposure to hypo (10‰)- and hyper (35‰)-osmotic salinity on hard clams raised at their natural salinity (20‰). The osmolality, [Na(+)], and [Cl(-)] of the hard clam hemolymph were changed in the same direction as the surrounding salinity. Further, the contents of total free amino acids including taurine in the gills and mantles were significantly upregulated in hard clam with increasing salinity. The gill Na(+), K(+)-ATPase (NKA) activity, the important enzyme regulating cellular inorganic ions, was not affected by the changed salinity. Mantle NKA activity, however, was stimulated in the 35‰ SW treatment. The taurine transporter (TAUT) is related to the regulation of intracellular contents of taurine, the dominant osmolyte. Herein, a TAUT gene of hard clam was cloned and a TAUT antibody was derived for the immunoblotting. The TAUT mRNA expression of the mantle in hard clam was significantly stimulated in 35‰ SW, but protein expression was not modulated by the changed salinity. In gills of the hard clam with 10‰ SW, both TAUT mRNA and protein expressions were significantly stimulated, and it may reflect a feedback regulation from the decreased gills taurine content under long-term hypoosmotic acclimation. These findings suggest that TAUT expression is regulated differently in gills and mantles following exposure to alterations in environmental salinity. Taken together, this study used the physiological, biochemical and molecular approaches to simultaneously explore the

  12. Gibberellins in Penicillium strains: Challenges for endophyte-plant host interactions under salinity stress. (United States)

    Leitão, Ana Lúcia; Enguita, Francisco J


    The genus Penicillium is one of the most versatile "mycofactories", comprising some species able to produce gibberellins, bioactive compounds that can modulate plant growth and development. Although plants have the ability to synthesize gibberellins, their levels are lower when plants are under salinity stress. It has been recognized that detrimental abiotic conditions, such as saline stress, have negative effects on plants, being the availability of bioactive gibberellins a critical factor for their growth under this conditions. This review summarizes the interplay existing between endophytic Penicillium strains and plant host interactions, with focus on bioactive gibberellins production as a fungal response that allows plants to overcome salinity stress.

  13. Ionic and photosynthetic homeostasis in quinoa challenged by drought and salinity – mechanisms of tolerance

    DEFF Research Database (Denmark)

    Razzaghi, Fatemeh; Jacobsen, Sven-Erik; Jensen, Christian Richardt


    Quinoa (Chenopodium quinoa Willd.) grown under field conditions was exposed to five irrigation water salinities (0, 10, 20, 30 and 40 dS m–1; 4 : 1 NaCl : CaCl2 molar ratio) from flowering, and divided between full irrigation and progressive drought (PD) during seed filling. Quinoa demonstrated...... homeostatic mechanisms which contributed to quinoa’s extraordinary tolerance. Salinity increased K+ and Na+ uptake by 60 and 100 kg ha–1, respectively, resulting in maintenance of cell turgor by osmotic adjustment, and a 50% increase of the leaf’s fresh weight (FW) : dry weight (DW) ratio and non...

  14. Salty or Sweet: Exploring the Challenges of Groundwater Salinization Within a Sustainability Framework (United States)

    Basu, N. B.; Van Meter, K. J.; Tate, E.


    In semi-arid to arid landscapes under intensive irrigation, groundwater salinization can be a persistent and critical problem, leading to reduced agricultural productivity, limited access to fresh drinking water, and ultimately desertification. It is estimated that in India alone, problems of salinity are now affecting over 6 million hectares of agricultural land. In villages of the Mewat district of Haryana in Northern India, subsistence-level farming is the primary source of income, and farming families live under serious threat from increasing salinity levels, both in terms of crop production and adequate supplies of drinking water. The Institute for Rural Research and Development (IRRAD), a non-governmental organization (NGO) working in Mewat, has taken an innovative approach in this area to problems of groundwater salinization, using check dams and rainwater harvesting ponds to recharge aquifers in the freshwater zones of upstream hill areas, and to create freshwater pockets within the saline groundwater zones of down-gradient areas. Initial, pilot-scale efforts have led to apparent success in raising groundwater levels in freshwater zones and changing the dynamics of encroaching groundwater salinity, but the expansion of such efforts to larger-scale restoration is constrained by the availability of adequate resources. Under such resource constraints, which are typical of international development work, it becomes critical to utilize a decision-analysis framework to quantify both the immediate and long-term effectiveness and sustainability of interventions by NGOs such as IRRAD. In the present study, we have developed such a framework, linking the climate-hydrological dynamics of monsoon driven systems with village-scale socio-economic attributes to evaluate the sustainability of current restoration efforts and to prioritize future areas for intervention. We utilize a multi-dimensional metric that takes into account both physical factors related to water

  15. Regulation by arbuscular mycorrhizae of the integrated physiological response to salinity in plants: new challenges in physiological and molecular studies. (United States)

    Ruiz-Lozano, Juan Manuel; Porcel, Rosa; Azcón, Charo; Aroca, Ricardo


    Excessive salt accumulation in soils is a major ecological and agronomical problem, in particular in arid and semi-arid areas. Excessive soil salinity affects the establishment, development, and growth of plants, resulting in important losses in productivity. Plants have evolved biochemical and molecular mechanisms that may act in a concerted manner and constitute the integrated physiological response to soil salinity. These include the synthesis and accumulation of compatible solutes to avoid cell dehydration and maintain root water uptake, the regulation of ion homeostasis to control ion uptake by roots, compartmentation and transport into shoots, the fine regulation of water uptake and distribution to plant tissues by the action of aquaporins, the reduction of oxidative damage through improved antioxidant capacity and the maintenance of photosynthesis at values adequate for plant growth. Arbuscular mycorrhizal (AM) symbiosis can help the host plants to cope with the detrimental effects of high soil salinity. There is evidence that AM symbiosis affects and regulates several of the above mentioned mechanisms, but the molecular bases of such effects are almost completely unknown. This review summarizes current knowledge about the effects of AM symbiosis on these physiological mechanisms, emphasizing new perspectives and challenges in physiological and molecular studies on salt-stress alleviation by AM symbiosis.

  16. Acute intermittent porphyria and pregnancy: an obstetric challenge

    Directory of Open Access Journals (Sweden)

    Pragati Meena


    Full Text Available Acute intermittent porphyria is a rare autosomal dominant disease caused by a mutation in the gene coding for the porphobillinogen deaminase enzymes in heam biosynthesis. The disease manifests as acute attacks of neuropsychiatric dysfunction and neurovisceral manifestations presenting as acute abdomen. In pregnancy, 54% patient has exacerbation of attacks in the form of seizures and acute abdomen occurs due to hormonal changes. Prevalence of acute intermittent porphyria is 1-2/200000 in general. Here we report a case of 36 year old women, G4P1L2A2 presenting at 10+4 weeks of gestation requesting pregnancy termination. Patient was diagnosed as case of acute intermittent porphyria with porphyic polyneuropathy 6 months back. At that time her main symptoms were acute pain abdomen with numbness and weakness in all four limbs. Her urinary porphobillinogen and 5 ALA raised. Her CECT of brain and nerve conduction studies were normal. Since then she is on Tablet Gabapentin 300 mg H.S. She underwent successful pregnancy termination by suction and evacuation under spinal anesthesia and she refused for copper-T insertion. Only safe drugs were used for procedure and she was discharged with advice of barrier contraception. [Int J Reprod Contracept Obstet Gynecol 2016; 5(2.000: 542-544

  17. Acute kidney injury in pregnancy: a clinical challenge


    Machado, S.; Figueiredo, N.; Borges, A.; Pais, MS; Freitas, L; Moura, P.; Campos, M.


    The incidence of acute kidney injury in pregnancy declined significantly over the second half of the 20th century; however, it is still associated with major maternal and perinatal morbidity and mortality. A set of systemic and renal physiological adaptive mechanisms occur during a normal gestation that will constrain several changes in laboratory parameters of renal function, electrolytes, fluid and acid-base balances. The diagnosis of acute kidney injury in pregnancy is based on the serum c...

  18. Rapid Endovascular Catheter Core Cooling combined with cold saline as an Adjunct to Percutaneous Coronary Intervention For the Treatment of Acute Myocardial Infarction (The CHILL-MI trial)

    DEFF Research Database (Denmark)

    Erlinge, David; Götberg, Matthias; Lang, Irene;


    : In a multicenter study, 120 patients with ST-segment elevation myocardial infarctions (care. Hypothermia was initiated...... incidence of heart failure and a possible effect in patients with early anterior ST-segment elevation myocardial infarctions need confirmation. (Efficacy of Endovascular Catheter Cooling Combined With Cold Saline for the Treatment of Acute Myocardial Infarction [CHILL-MI]; NCT01379261)....


    Directory of Open Access Journals (Sweden)

    Petko Marinov


    Full Text Available Purpose: Methanol (CH3OH is a monohydric alcohol, vastly used both in housekeeping and industry. Although the acute methanol intoxications are rare, they may include life-threatening symptoms, substantial lethality and negative consequences such as neurological disorders and vision damage. Aim of the work is to conduct a retrospective study on the acute methanol intoxications within Varna region for a 10-year period (2006-2015. Material/Methods: This study covers 39 patients of the Clinic for Intensive Treatment of Acute Intoxications and Toxicoallergies at Naval Hospital – Varna, all of which had their diagnosis confirmed, including gas chromatography methods. Results: Methanol intoxication prevalence showed male/female ratio close to 2.9:1. The major part of the cases concerned economically active population, the age group of 25-60 being the most affected. In all instances an oral methanol intake has been involved. Death occurred in 14 cases (35.9%

  20. Acute pancreatitis in pregnancy: a challenge for the clinician

    Directory of Open Access Journals (Sweden)

    Urvashi Miglani


    Full Text Available Acute pancreatitis is one of the very rare events in pregnancy associated with high maternal and fetal morbidity and mortality. We are presenting a case of acute pancreatitis in a 25 year old G2P1L1 at 33 weeks of gestation with previous LSCS who presented to us with hypertension, epigastric pain, vomiting. Investigations revealed hyperamylysemia, hypertriglyceridemia and deranged liver enzymes. After examination and investigations, diagnosis of acute pancreatitis with pregnancy was made. She underwent caesarean section for obstetric hemorrhage and was put in intensive care for 3 days. She was discharged after. 1 week and is under regular follow up for past 6 months. [Int J Reprod Contracept Obstet Gynecol 2016; 5(7.000: 2448-2449

  1. Limb apraxia in acute ischemic stroke: a neglected clinical challenge? (United States)

    Schell, Caroline; Suchan, Julia; Himmelbach, Marc; Haarmeier, Thomas; Borchers, Svenja


    Symptoms of limb apraxia and executive dysfunctions are currently not explicitly considered by the National Institutes of Health Stroke Scale and, thus, not routinely tested by clinicians in the acute care of patients with suspected stroke. Neuropsychological testing, clinical examination, MRI, and functional magnetic resonance imaging (fMRI) were performed in a right-handed patient with acute onset of left-sided sensorimotor hemiparesis due to a right hemisphere ischemic stroke. Deficits in the execution of meaningless and meaningful gestures were not detected properly on initial clinical examination but were revealed later on through neuropsychological testing. Instead, the patient's inability to respond to specific instructions in the acute care setting was mistaken to reflect severe deficits in auditory comprehension. fMRI revealed right-hemispheric localization of language in the right-handed patient. We suggest including a bedside test for limb apraxia symptoms in acute clinical care of stroke patients. The distinction between deficits in limb praxis and impairments of language can be complicated owing to the common hemispheric co-localization of the two functions.

  2. The acute salinity changes activate the dual pathways of endocrine responses in the brain and pituitary of tilapia. (United States)

    Aruna, Adimoolam; Nagarajan, Ganesan; Chang, Ching-Fong


    To analyze and compare the stress and osmoregulatory hormones and receptors in pituitary during acute salinity changes, the expression patterns of corticotropin releasing hormone (crh) in hypothalamus, prolactin (prl) releasing peptide (pRrp) in telencephalon and diencephalon, glucocorticoid receptors 2 (gr2), and mineralocorticoid receptor (mr), crh-r, pro-opiomelanocorticotropin (pomc), pRrp, prl, dopamine 2 receptor (d2-r), growth hormone (gh), gh-receptor (gh-r) and insulin-like growth hormone (igf-1) transcripts in pituitary were characterized in euryhaline tilapia. The results indicate that the crh transcripts increased in the hypothalamus and rostral pars distalis of the pituitary after the transfer of fish to SW. Similarly, the pRrp transcripts were more abundant in SW acclimated tilapia forebrain and hypothalamus. The crh-r, gr2 and mr transcripts were more expressed in rostral pars distalis and pars intermedia of pituitary at SW than FW tilapia. The data indicate that the SW acclimation stimulates these transcripts in the specific regions of the brain and pituitary which may be related to the activation of the hypothalamic-pituitary-interrenal (HPI)-axis. The results of dual in situ hybridization reveal that the transcripts of crh-r, gr2 and mr with pomc are highly co-localized in corticotrophs of pituitary. Furthermore, we demonstrate high expression of pRrp in the brain and low expression of pRrp and prl transcripts in the pituitary of SW fish. No crh-r and corticosteroid receptors were co-localized with prl transcripts in the pituitary. The gh-r and igf-1 mRNA levels were significantly increased in SW acclimated tilapia pituitary whereas there was no difference in the gh mRNA levels. The data suggest that the locally produced pRrp and d2-r may control and regulate the expression of prl mRNA in pituitary. Therefore, the dual roles of pRrp are involved in the stress (via brain-pituitary) and osmoregulatory (via pituitary) pathways in tilapia exposed to

  3. Challenges of treating a 466-kilogram man with acute kidney injury. (United States)

    Friedman, Allon N; Decker, Brian; Seele, Louis; Hellman, Richard N


    Caring for super obese patients (body mass index > 50 kg/m(2)) presents a number of complex and unique clinical challenges, particularly when acute kidney injury is present. We describe our experience treating the heaviest individual with acute kidney injury requiring renal replacement therapy reported to date. A 24-year-old black man was admitted to our hospital with fever, vomiting, progressive weakness, shortness of breath, and hemoptysis. Admission weight was 1,024 lbs (466 kg), height was 6 ft 4 in (1.9 m), and body mass index was 125 kg/m(2). During hospitalization, the patient experienced oligoanuric acute kidney injury and required initiation of continuous and subsequently intermittent renal replacement therapy. This clinical scenario identifies the many challenges involved in caring for super obese patients with acute kidney injury and may be a harbinger of what awaits the nephrology community in the obesity pandemic era.

  4. Hypertonic saline enhances host response to bacterial challenge by augmenting receptor-independent neutrophil intracellular superoxide formation.

    LENUS (Irish Health Repository)

    Shields, Conor J


    OBJECTIVE: This study sought to determine whether hypertonic saline (HTS) infusion modulates the host response to bacterial challenge. METHODS: Sepsis was induced in 30 Balb-C mice by intraperitoneal injection of Escherichia coli (5 x 107 organisms per animal). In 10 mice, resuscitation was performed at 0 and 24 hours with a 4 mL\\/kg bolus of HTS (7.5% NaCl), 10 animals received 4 mL\\/kg of normal saline (0.9% NaCl), and the remaining animals received 30 mL\\/kg of normal saline. Samples of blood, spleen, and lung were cultured at 8 and 36 hours. Polymorphonucleocytes were incubated in isotonic or hypertonic medium before culture with E. coli. Phagocytosis was assessed by flow cytometry, whereas intracellular bacterial killing was measured after inhibition of phagocytosis with cytochalasin B. Intracellular formation of free radicals was assessed by the molecular probe CM-H(2)DCFDA. Mitogen-activated protein (MAP) kinase p38 and ERK-1 phosphorylation, and nuclear factor kappa B (NFkappaB) activation were determined. Data are represented as means (SEM), and an analysis of variance test was performed to gauge statistical significance. RESULTS: Significantly reduced bacterial culture was observed in the animals resuscitated with HTS when compared with their NS counterparts, in blood (51.8 +\\/- 4.3 vs. 82.0 +\\/- 3.3 and 78.4 +\\/- 4.8, P = 0.005), lung (40.0 +\\/- 4.1 vs. 93.2 +\\/- 2.1 and 80.9 +\\/- 4.7, P = 0.002), and spleen (56.4 +\\/- 3.8 vs. 85.4 +\\/- 4.2 and 90.1 +\\/- 5.9, P = 0.05). Intracellular killing of bacteria increased markedly (P = 0.026) and superoxide generation was enhanced upon exposure to HTS (775.78 +\\/- 23.6 vs. 696.57 +\\/- 42.2, P = 0.017) despite inhibition of MAP kinase and NFkappaB activation. CONCLUSIONS: HTS significantly enhances intracellular killing of bacteria while attenuating receptor-mediated activation of proinflammatory cascades.

  5. Frequency of Acute Kidney Injury in Patients Treated With Normal Saline after Off-Pump Coronary Artery Bypass Grafting

    Directory of Open Access Journals (Sweden)

    Shima Sheybani


    Full Text Available Introduction: Acute kidney injury (AKI is a common postoperative complication of cardiac surgery, which is associated with an increased risk of morbidity and mortality. This study investigated the frequency of postoperative AKI in low risk adult patients undergoing off-pump coronary artery bypass grafting (CABG.Materials & Methods: All consecutive adult patients of American Society of Anesthesiologists (ASA class II and III, who were transferred to the post-operative cardiac surgery ICU after off-pump CABG and were low risk for AKI from October 2013 to September 2014 at Emam Reza Hospital, Mashhad, Iran were enrolled in this prospective cohort study at a teaching hospital. The patients were explored for AKI development, based on risk-injury-failure-loss- end stage kidney disease (RIFLE and acute kidney injury network (AKIN criteria, frequency of metabolic acidosis, hypernatremia, hyperchloremia, and length of stay in ICU.Results: According to the results of the present study, 479 patients with the mean age of 60.8±10.75 yrs were included. AKI occurred in 22 (4.4% and23 (4.8% patients, based on both the RIFLE and AKIN criteria, respectively with the highest rate of AKI, reported on the third and fourth post-operative days. Additionally, hyperchloremia and hypernatremia were observed in 71 (14.8% and 76 (15.9% patients, respectively. Only one case of mortality occurred during the study. Metabolic acidosis was reported in 112 (23.4% patients with a high anion gap in 60 (12.5% cases.Conclusion: The current study demonstrated that hypernatremia and metabolic acidosis but not AKI are frequently seen in patients receiving normal saline following off pump CABG with low risk for AKI.

  6. Rapid Aspirin Challenge in Patients with Aspirin Allergy and Acute Coronary Syndromes. (United States)

    Cook, Kevin A; White, Andrew A


    Aspirin allergy in a patient with acute coronary syndrome represents one of the more urgent challenges an allergist may face. Adverse reactions to aspirin are reported in 1.5% of patients with coronary artery disease. A history of adverse reaction to aspirin often leads to unnecessary withholding of this medication or use of alternative antiplatelet therapy which may be inferior or more costly. Aspirin therapy has been shown to reduce morbidity and mortality in patients with coronary artery disease. Rapid aspirin challenge/desensitization in the aspirin allergic patient has been consistently shown to be both safe and successful in patients with acute coronary syndromes.

  7. Side effects induced by the acute levodopa challenge in Parkinson’s Disease and atypical parkinsonisms (United States)

    Mostile, Giovanni; Dibilio, Valeria; Sciacca, Giorgia; Contrafatto, Donatella; Cicero, Calogero Edoardo; Raciti, Loredana; Luca, Antonina; Zappia, Mario


    Introduction Acute levodopa challenge may be performed to predict levodopa chronic responsiveness. The aim of the study was to investigate frequency of side effects during the acute levodopa challenge in PD and atypical parkinsonisms. Methods We enrolled 34 de novo PD patients and 29 patients affected by atypical parkinsonisms (Multiple System Atrophy, MSA, n = 10; Progressive Supranuclear Palsy, PSP, n = 12 and Corticobasal Degeneration, CBD, n = 7) who underwent an acute levodopa challenge. Side effects occurring during test were recorded. Results Side effects were more frequent among atypical parkinsonisms as unique group when compared to PD patients (64.3% versus 23.5%; p-value 0.002) with an adjusted OR of 4.36 (95%CI 1.40–13.5). Each atypical parkinsonisms showed almost double occurrence of side effects (MSA 90%, PSP 41.7% and CBD 57%). Conclusions Side effects during acute levodopa challenge may be frequent in atypical parkinsonisms. This information could be useful in order to better prepare the patient for the test. Furthermore, it could represent a useful cue in differential diagnosis with PD. PMID:28207803

  8. Different expression patterns of renal Na(+)/K(+)-ATPase α-isoform-like proteins between tilapia and milkfish following salinity challenges. (United States)

    Yang, Wen-Kai; Chung, Chang-Hung; Cheng, Hui Chen; Tang, Cheng-Hao; Lee, Tsung-Han


    Euryhaline teleosts can survive in a broad range of salinity via alteration of the molecular mechanisms in certain osmoregulatory organs, including in the gill and kidney. Among these mechanisms, Na(+)/K(+)-ATPase (NKA) plays a crucial role in triggering ion-transporting systems. The switch of NKA isoforms in euryhaline fish gills substantially contributes to salinity adaptation. However, there is little information about switches in the kidneys of euryhaline teleosts. Therefore, the responses of the renal NKA α-isoform protein switch to salinity challenge in euryhaline tilapia (Oreochromis mossambicus) and milkfish (Chanos chanos) with different salinity preferences were examined and compared in this study. Immunohistochemical staining in tilapia kidneys revealed the localization of NKA in renal tubules rather than in the glomeruli, similar to our previous findings in milkfish kidneys. Protein abundance in the renal NKA pan α-subunit-like, α1-, and α3-isoform-like proteins in seawater-acclimated tilapia was significantly higher than in the freshwater group, whereas the α2-isoform-like protein exhibited the opposite pattern of expression. In the milkfish, higher protein abundance in the renal NKA pan α-subunit-like and α1-isoform-like proteins was found in freshwater-acclimated fish, whereas no difference was found in the protein abundance of α2- and α3-isoform-like proteins between groups. These findings suggested that switches for renal NKA α-isoforms, especially the α1-isoform, were involved in renal osmoregulatory mechanisms of euryhaline teleosts. Moreover, differences in regulatory responses of the renal NKA α-subunit to salinity acclimation between tilapia and milkfish revealed that divergent mechanisms for maintaining osmotic balance might be employed by euryhaline teleosts with different salinity preferences.


    Institute of Scientific and Technical Information of China (English)

    王永兴; 刘治全; 刘艳; 侯嵘; 叶涛


    Objective To observe the changes of plasma AngⅡ,ANP and their relationship with urine sodium excretion in salt sensitive hypertension. Methods The salt sensitivity was determined by acute saline loading test in 173 primary hypertensives of Stage Ⅰ or Stage Ⅱ. Plasma AngⅡand ANP was determined by radioimmunoassay. Results After acute salt load, AngⅡ was suppressed inadequately. The plasma ANP secretion was not increased. The urine sodiun excretion was delayed, Na+ in RBC was increased in salt sensitive subjects. The plasma ANP was decreased in the salt sensitive subjects without AngⅡ suppressed. The 24 hours urine sodium excretion was lower than those AngⅡ suppressed.Conclusion The changes of plasma RAS are not homogeneous after salt load. Those without the plasma AngⅡ suppressed have more severe sodium metabolism abnormalities and the endogenous ANP secretion is impaired in salt sensitive patients.

  10. Salinization and Saline Environments (United States)

    Vengosh, A.


    One of the most conspicuous phenomena of water-quality degradation, particularly in arid and semi-arid zones, is salinization of water and soil resources. Salinization is a long-term phenomenon, and during the last century many aquifers and river basins have become unsuitable for human consumption owing to high levels of salinity. Future exploitation of thousands of wells in the Middle East and in many other water-scarce regions in the world depends, to a large extent, on the degree and rate of salinization. Moreover, every year a large fraction of agricultural land is salinized and becomes unusable.Salinization is a global environmental phenomenon that affects many different aspects of our life (Williams, 2001a, b): changing the chemical composition of natural water resources (lakes, rivers, and groundwater), degrading the quality of water supply to the domestic and agriculture sectors, contribution to loss of biodiversity, taxonomic replacement by halotolerant species ( Williams, 2001a, b), loss of fertile soil, collapse of agricultural and fishery industries, changing of local climatic conditions, and creating severe health problems (e.g., the Aral Basin). The damage due to salinity in the Colorado River Basin alone, for example, ranges between 500 and 750 million per year and could exceed 1 billion per year if the salinity in the Imperial Dam increases from 700 mg L-1 to 900 mg L-1 (Bureau of Reclamation, 2003, USA). In Australia, accelerating soil salinization has become a massive environmental and economic disaster. Western Australia is "losing an area equal to one football oval an hour" due to spreading salinity ( Murphy, 1999). The annual cost for dryland salinity in Australia is estimated as AU700 million for lost land and AU$130 million for lost production ( Williams et al., 2002). In short, the salinization process has become pervasive.Salinity in water is usually defined by the chloride content (mg L-1) or total dissolved solids content (TDS, mg L-1or g

  11. Nebulized hypertonic saline treatment reduces both rate and duration of hospitalization for acute bronchiolitis in infants: an updated meta-analysis. (United States)

    Chen, Yen-Ju; Lee, Wen-Li; Wang, Chuang-Ming; Chou, Hsin-Hsu


    Nebulized hypertonic saline (HS) treatment reduced the length of hospitalization in infants with acute bronchiolitis in a previous meta-analysis. However, there was no reduction in the admission rate. We hypothesized that nebulized HS treatment might significantly decrease both the duration and the rate of hospitalization if more randomized controlled trials (RCTs) were included. We searched MEDLINE, PubMed, CINAHL, and the Cochrane Central Register of Controlled Trials (CENTRAL) without a language restriction. A meta-analysis was performed based on the efficacy of nebulized HS treatment in infants with acute bronchiolitis. We used weighted mean difference (WMD) and risk ratio as effect size metrics. Eleven studies were identified that enrolled 1070 infants. Nebulized HS treatment significantly decreased the duration and rate of hospitalization compared with nebulized normal saline (NS) [duration of hospitalization: WMD = -0.96, 95% confidence interval (CI) = -1.38 to -0.54, p bronchiolitis infants post-treatment (Day 1: WMD = -0.77, 95% CI = -1.30 to -0.24, p = 0.005; Day 2: WMD = -0.85, 95% CI = -1.30 to -0.39, p bronchiolitis in infants.

  12. Sweat-inducing physiological challenges do not result in acute changes in hair cortisol concentrations. (United States)

    Grass, Juliane; Kirschbaum, Clemens; Miller, Robert; Gao, Wei; Steudte-Schmiedgen, Susann; Stalder, Tobias


    Hair cortisol concentrations (HCC) are assumed to provide a stable, integrative marker of long-term systemic cortisol secretion. However, contrary to this assumption, some recent observations have raised the possibility that HCC may be subject to acute influences, potentially related to cortisol incorporation from sweat. Here, we provide a first detailed in vivo investigation of this possibility comprising two independent experimental studies: study I (N=42) used a treadmill challenge to induce sweating together with systemic cortisol reactivity while in study II (N=52) a sauna bathing challenge induced sweating without systemic cortisol changes. In both studies, repeated assessments of HCC, salivary cortisol, cortisol in sweat and individuals' sweating rate (single assessment) were conducted on the experimental day and at a next-day follow-up. Results across the two studies consistently revealed that HCC were not altered by the acute interventions. Further, HCC were found to be unrelated to acute salivary cortisol reactivity, sweat cortisol levels, sweating rate or the time of examination. In line with previous data, cortisol levels in sweat were strongly related to total salivary cortisol output across the examined periods. The present results oppose recent case report data by showing that single sweat-inducing interventions do not result in acute changes in HCC. Our data also tentatively speak against the notion that cortisol in sweat may be a dominant source of HCC. Further, our findings also indicate that HCC are not subject to diurnal variation. This research provides further support for hair cortisol analysis as a marker of integrated long-term systemic cortisol secretion.

  13. Challenges in implementing individualized medicine illustrated by antimetabolite therapy of childhood acute lymphoblastic leukemia

    DEFF Research Database (Denmark)

    Nersting, Jacob; Borst, Louise; Schmiegelow, Kjeld


    of acceptable toxicity, an individualized therapeutic approach is indicated. The mapping of the human genome and technological developments in DNA sequencing, gene expression profiling, and proteomics have raised the expectations for implementing genotype-phenotype data into the clinical decision process...... illustrated by studies involving childhood acute lymphoblastic leukemia (ALL), where each patient may receive up to 13 different anticancer agents over a period of 2-3 years. The challenges include i) addressing important, but low-frequency outcomes, ii) difficulties in interpreting the impact of single drug...

  14. Metrological challenges for measurements of key climatological observables: oceanic salinity and pH, and atmospheric humidity. Part 1: overview (United States)

    Feistel, R.; Wielgosz, R.; Bell, S. A.; Camões, M. F.; Cooper, J. R.; Dexter, P.; Dickson, A. G.; Fisicaro, P.; Harvey, A. H.; Heinonen, M.; Hellmuth, O.; Kretzschmar, H.-J.; Lovell-Smith, J. W.; McDougall, T. J.; Pawlowicz, R.; Ridout, P.; Seitz, S.; Spitzer, P.; Stoica, D.; Wolf, H.


    Water in its three ambient phases plays the central thermodynamic role in the terrestrial climate system. Clouds control Earth’s radiation balance, atmospheric water vapour is the strongest ‘greenhouse’ gas, and non-equilibrium relative humidity at the air-sea interface drives evaporation and latent heat export from the ocean. On climatic time scales, melting ice caps and regional deviations of the hydrological cycle result in changes of seawater salinity, which in turn may modify the global circulation of the oceans and their ability to store heat and to buffer anthropogenically produced carbon dioxide. In this paper, together with three companion articles, we examine the climatologically relevant quantities ocean salinity, seawater pH and atmospheric relative humidity, noting fundamental deficiencies in the definitions of those key observables, and their lack of secure foundation on the International System of Units, the SI. The metrological histories of those three quantities are reviewed, problems with their current definitions and measurement practices are analysed, and options for future improvements are discussed in conjunction with the recent seawater standard TEOS-10. It is concluded that the International Bureau of Weights and Measures, BIPM, in cooperation with the International Association for the Properties of Water and Steam, IAPWS, along with other international organizations and institutions, can make significant contributions by developing and recommending state-of-the-art solutions for these long standing metrological problems in climatology.

  15. Acute toxicity, accumulation and tissue distribution of copper in the blue crab Callinectes sapidus acclimated to different salinities: In vivo and in vitro studies

    Energy Technology Data Exchange (ETDEWEB)

    De Martinez Gaspar Martins, Camila [Programa de Pos-Graduacao em Ciencias Fisiologicas - Fisiologia Animal Comparada, Instituto de Ciencias Biologicas, Universidade Federal do Rio Grande (FURG), Campus Carreiros, Av. Italia km 8, 96201-900, Rio Grande, RS (Brazil); Barcarolli, Indianara Fernanda; Menezes, Eliana Jaime de; Mussoi Giacomin, Marina [Instituto de Ciencias Biologicas, Universidade Federal do Rio Grande (FURG), Campus Carreiros, Av. Italia km 8, 96201-900, Rio Grande, RS (Brazil); Wood, Chris M. [McMaster University, Department of Biology, 1280 Main Street West, Hamilton, ON, L8S 4K1 (Canada); Bianchini, Adalto, E-mail: [Programa de Pos-Graduacao em Ciencias Fisiologicas - Fisiologia Animal Comparada, Instituto de Ciencias Biologicas, Universidade Federal do Rio Grande (FURG), Campus Carreiros, Av. Italia km 8, 96201-900, Rio Grande, RS (Brazil); Instituto de Ciencias Biologicas, Universidade Federal do Rio Grande (FURG), Campus Carreiros, Av. Italia km 8, 96201-900, Rio Grande, RS (Brazil)


    In vivo and in vitro studies were performed to evaluate acute toxicity, organ-specific distribution, and tissue accumulation of copper in Callinectes sapidus acclimated to two different experimental salinities (2 and 30 ppt). Blue crabs were quite tolerant to copper. Acute dissolved copper toxicity (96-h LC{sub 50} and its corresponding 95% confident interval) was higher at salinity 2 ppt (5.3 (3.50-8.05) {mu}M Cu) than at 30 ppt (53.0 (27.39-102.52) {mu}M Cu). The difference between salinities can be completely explained based on the water chemistry because it disappeared when 96-h LC{sub 50} values were expressed as the free Cu{sup 2+} ion (3.1 (1.93-4.95) {mu}M free Cu at 2 ppt versus 5.6 (2.33-13.37) {mu}M free Cu at 30 ppt) or the Cu{sup 2+} activity (1.4 (0.88-2.26) {mu}M Cu activity at 2 ppt versus 1.7 (0.71-4.07) {mu}M Cu activity at 30 ppt). The relationships between gill Cu burden and % mortality were very similar at 2 and 30 ppt, in accord with the Biotic Ligand Model. In vivo experiments showed that copper concentration in the hemolymph is not dependent on metal concentration in the surrounding medium at either experimental salinity. They also showed that copper flux into the gills is higher than into other tissues analyzed, and that anterior and posterior gills are similarly important sites of copper accumulation at both experimental salinities. In vitro experiments with isolated-perfused gills showed that there is a positive relationship between copper accumulation in this tissue and the metal concentration in the incubation media for both anterior and posterior gills. A similar result was observed at both low and high salinities. Furthermore, in vitro experiments showed that copper accumulation in posterior gills is also positively and strongly dependent on the incubation time with copper. Gill copper accumulation occurred at a lower rate in the first 2 h of metal exposure, increasing markedly after this 'steady-state' period. This finding

  16. Reduced triglyceride secretion in response to an acute dietary fat challenge in obese compared to lean mice.

    Directory of Open Access Journals (Sweden)

    Aki eUchida


    Full Text Available Obesity results in abnormally high levels of triglyceride (TG storage in tissues such as liver, heart and muscle, which disrupts their normal functions. Recently, we found that lean mice challenged with high levels of dietary fat store TGs in cytoplasmic lipid droplets in the absorptive cells of the intestine, enterocytes, and that this storage increases and then decreases over time after an acute dietary fat challenge. The goal of this study was to investigate the effects of obesity on intestinal TG metabolism. More specifically we asked whether TG storage in and secretion from the intestine are altered in obesity. We investigated these questions in diet-induced obese (DIO and leptin-deficient (ob/ob mice. We found greater levels of TG storage in the intestine of DIO mice compared to lean mice in the fed state, but similar levels of TG storage after fasting. In addition, we found similar TG storage in the intestine of lean and DIO mice at multiple time points after an acute dietary fat challenge. Surprisingly, we found remarkably lower TG secretion from both DIO and ob/ob mice compared to lean controls in response to an acute dietary fat challenge. Furthermore, we found altered mRNA levels for genes involved in regulation of intestinal TG metabolism in lean and DIO mice at fasting and in response to an acute dietary fat challenge. More specifically, we found that many of the genes related to TG synthesis, chylomicron synthesis, TG storage and lipolysis were induced in response to an acute dietary fat challenge in lean mice, but this induction was not observed in DIO mice. In fact, we found a significant decrease in intestinal mRNA levels of genes related to lipolysis and fatty acid oxidation in DIO mice in response to an acute dietary fat challenge. Our findings demonstrate altered TG handling by the small intestine of obese compared to lean mice.

  17. Molecular characterization and transcriptional regulation of the Na +/K+ ATPase α subunit isoforms during development and salinity challenge in a teleost fish, the Senegalese sole (Solea senegalensis). (United States)

    Armesto, Paula; Campinho, Marco A; Rodríguez-Rúa, Ana; Cousin, Xavier; Power, Deborah M; Manchado, Manuel; Infante, Carlos


    In the present work, five genes encoding different Na(+),K(+) ATPase (NKA) α-isoforms in the teleost Solea senegalensis are described for the first time. Sequence analysis of predicted polypeptides revealed a high degree of conservation across teleosts and mammals. Phylogenetic analysis clustered the five genes into three main clades: α1 (designated atp1a1a and atp1a1b), α2 (designated atp1a2) and α3 (designated atp1a3a and atp1a3b) isoforms. Transcriptional analysis in larvae showed distinct expression profiles during development. In juvenile tissues, the atp1a1a gene was highly expressed in osmoregulatory organs, atp1a2 in skeletal muscle, atp1a1b in brain and heart and atp1a3a and atp1a3b mainly in brain. Quantification of mRNA abundance after a salinity challenge showed that atp1a1a transcript levels increased significantly in the gill of soles transferred to high salinity water (60 ppt). In contrast, atp1a3a transcripts increased at low salinity (5 ppt). In situ hybridization (ISH) analysis revealed that the number of ionocytes expressing atp1a1a transcripts in the primary gill filaments was higher at 35 and 60 ppt than at 5 ppt and remained undetectable or at very low levels in the lamellae at 5 and 35 ppt but increased at 60 ppt. Immunohistochemistry showed a higher number of positive cells in the lamellae. Whole-mount analysis of atp1a1a mRNA in young sole larvae revealed that it was localized in gut, pronephric tubule, gill, otic vesicle, yolk sac ionocytes and chordacentrum. Moreover, atp1a1a mRNAs increased at mouth opening (3 DPH) in larvae incubated at 36 ppt with a greater signal in gills.

  18. Indicators: Salinity (United States)

    Salinity is the dissolved salt content of a body of water. Excess salinity, due to evaporation, water withdrawal, wastewater discharge, and other sources, is a chemical sterssor that can be toxic for aquatic environments.

  19. Prenatal transportation alters the acute phase response (APR) of bull calves exposed to a lipopolysaccharide (LPS) challenge (United States)

    This study was designed to determine if prenatal transportation influences the acute phase response (APR) to a postnatal Lipopolysaccharide (LPS) challenge. Pregnant Brahman cows (n=96) matched by age and parity were separated into transported (TRANS; n=48; transported for 2 hours on gestational day...

  20. Supplementation of Lactobacillus acidophilus fermentation product can attenuate the acute phase response following a lipopolysaccharide challenge in pigs. (United States)

    This study was designed to determine if feeding a Lactobacillus acidophilus fermentation product to weaned pigs would reduce stress and acute phase responses (APR) following a lipopolysaccharide (LPS) challenge. Pigs (n=30; 6.4±0.1 kilograms body weight) were housed individually in pens with ad libi...

  1. OmniGen-AF supplementation modulated the physiological and acute phase responses of Brahman heifers to an endotoxin challenge (United States)

    This study examined the effect of feeding OmniGen-AF (OG; Prince Agri Products) on the physiological and acute phase responses (APR) of newly-weaned heifers to an endotoxin (lipopolysaccharide; LPS) challenge. Brahman heifers (n=24; 183±5 kilograms) from the Texas AgriLife Research Center in Overton...

  2. The effect of yeast cell wall supplementation on the physiological and acute phase responses of crossbred heifers to endotoxin challenge (United States)

    A study was conducted to determine the effect of feeding yeast cell wall (YCW) products on the physiological and acute phase responses of crossbred newly-received heifers to endotoxin (lipopolysaccharide; LPS) challenge. Heifers (n=24; 218.9+/-2.4 kg) were obtained from commercial sale barns and tra...

  3. Yeast cell wall supplementation alters the physiological and acute phase responses of crossbred heifers to an endotoxin challenge (United States)

    A study was conducted to determine the effect of feeding yeast cell wall (YCW) products on the physiological and acute phase responses of crossbred newly-received heifers to an endotoxin challenge. Heifers (n = 24; 219 ± 2.4 kg) were separated into treatment groups receiving a Control diet (n = 8), ...

  4. Dried citrus pulp modulates the physiological and acute phase responses of crossbred heifers to an endotoxin challenge (United States)

    This study examined the effect of feeding dried citrus pulp (CP) pellets on the physiological and acute phase responses (APR) of newly-received crossbred heifers to an endotoxin (lipopolysaccharide; LPS) challenge. Heifers (n=24; 218.3±2.4 kg) were obtained from commercial sale barns and transported...

  5. Proteomic approach for acute-phase proteins of hemolymph and muscles in Scylla serrata challenged by a pathogenic bactedum

    Institute of Scientific and Technical Information of China (English)

    LIU Wenjie; SU Jing; WANG Guizhong; WANG Sanying


    Acute-phase response is documented to be a significant mechanism of innate immunity in vertebrates and invertebrates.In this study,proteomic methodologies were applied for different protein expressions in hemolymph of Scylla serrata challenged by Vibrio parahaemolyticus after immunization,and in muscles of the crabs separately challenged by V.parahaemolyticus.V.anguillarum and Aeromonas hydrophila.Up-regulated cryptocyanin is documented in the hemolymph and up-regulated calexcitin,wingless(fragment)and tachykinin-related peptide in the muscle as acute-phase proteins.All the four altered proteins were responsible for bacterial stress,but cryptocyanin seemed to be a memory response protein against the challenge by a live bacterium after immunization of the live cells.These up-regulated proteins can be indicative of an understanding of immunity of a crab.

  6. Challenges faced in the treatment of acute lymphoblastic leukemia in adolescents and young adults

    Directory of Open Access Journals (Sweden)

    Levine SR


    Full Text Available Selena R Levine,1 Jennifer L McNeer,2 Michael S Isakoff1 1Center for Cancer and Blood Disorders, Connecticut Children’s Medical Center and University of Connecticut School of Medicine, Hartford, CT, 2Section of Pediatric Hematology/Oncology, University of Chicago Comer Children's Hospital, Chicago, IL, USA Abstract: The survival rate for children with acute lymphoblastic leukemia (ALL has dramatically improved over the last 50 years. However, for those in the adolescent and young adult (AYA age-group of 15–30 years with ALL, there has not been the same degree of improvement. Historically, pediatric and adult providers have utilized different treatment approaches based on clinical trials. However, studies that have compared the outcome of AYA patients with ALL treated on pediatric or adult clinical trials have generally shown substantially better outcomes for this patient population treated with the pediatric trials. Additionally, hematopoietic stem cell transplantation has been considered as part of intensified therapy for AYA patients with ALL. Herein, we review the outcomes with chemotherapy alone and with hematopoietic stem cell transplantation, and explore the challenges faced in determining the ideal therapy for the AYA population of patients. Keywords: adolescent young adult oncology, leukemia, hematopoietic stem cell transplantation

  7. Pheochromocytoma presenting as an acute coronary syndrome complicated by acute heart failure: The challenge of a great mimic

    Directory of Open Access Journals (Sweden)

    Giuseppe Damiano Sanna


    Full Text Available Pheochromocytoma is a rare neuroendocrine tumor with a highly variable clinical presentation. The serious and potentially lethal cardiovascular complications of these tumors are related to the effects of secreted catecholamines. We describe a case of a 50-year-old woman urgently admitted to our hospital because of symptoms and clinical and instrumental findings consistent with an acute coronary syndrome complicated by acute heart failure. Urgent coronary angiography showed normal coronary arteries. During her hospital stay, the recurrence of episodes characterized by a sudden increase in blood pressure, cold sweating, and nausea allowed us to hypothesize a pheochromocytoma. The diagnosis was confirmed by elevated levels of urinary catecholamines and by the finding of a left adrenal mass on magnetic resonance imaging. The patient underwent left adrenalectomy. Therefore, the initial diagnosis was critically reappraised and reviewed as a cardiac manifestation of a pheochromocytoma during catecholaminergic crisis.

  8. Acute bithalamic infarct manifesting as sleep-like coma: A diagnostic challenge. (United States)

    Honig, Asaf; Eliahou, Ruth; Eichel, Roni; Shemesh, Ari Aharon; Ben-Hur, Tamir; Auriel, Eitan


    Bilateral thalamic infarction (BTI) typically presents as a sleep-like coma (SLC) without localizing signs, posing a diagnostic challenge that may lead the treating physician to search for toxic or metabolic causes and delay treatment. We review our experience with BTI of different etiologies, and emphasize the critical role of timely imaging, diagnosis, and management in a series of 12 patients with a presentation of SLC and acute BTI who were managed in our Medical Centers from 2006-2015. In 11/12, urgent head CT scans showed normal brain tissue, while diffusion-weighted (DWI) MRI revealed symmetric bilateral thalamic hyperintense lesions with variable degrees of brainstem involvement. In 1/12, CT scans revealed a contralateral subacute stroke from a thalamic infarct 1month earlier with a unilateral hyperintense lesion on DWI-MRI. From clinical and imaging findings (DWI-MRI, CT angiography and venography), etiology was attributed to embolic causes (cardio-embolism, artery-to-artery mechanism), small vessel disease, or deep sinus vein thrombosis secondary to dural arteriovenous (AV) fistula. Three patients had good outcomes after prompt diagnosis and optimal treatment in <3hours (intravenous tissue plasminogen activator in two patients cardio-embolic etiology and neuro-endovascular repair in one patient with venous infarction due to a dural AV fistula). The diagnosis was made beyond the therapeutic window in seven patients, who were left with significant neurological sequelae. Higher awareness of BTI presenting as SLC is warranted. Optimal patient management includes urgent DWI-MRI. In cases of BTI, further imaging workup is indicated to provide a comprehensive assessment for etiology. Early diagnosis and prompt, targeted intervention are crucial.

  9. Salinity Energy. (United States)

    Schmitt, Walter R.


    Discussed are the costs of deriving energy from the earth's natural reserves of salt. Argues that, as fossil fuel supplies become more depleted in the future, the environmental advantages of salinity power may prove to warrant its exploitation. (TW)

  10. Modulation of the acute phase response following a lipopolysaccharide challenge in pigs supplemented with an all-natural Saccharomyces cerevisiae fermentation product (United States)

    This study was designed to determine if feeding a Saccharomyces cerevisiae fermentation product to weaned pigs would reduce the stress and acute phase responses (APR) following an acute lipopolysaccharide (LPS) challenge. Pigs (n = 20; 6.4 +/- 0.2 kg body weight) were obtained and transported to an ...

  11. [Clinical case--voluminous diaphragmatic hernia--surgically acute abdomen: diagnostic and therapeutical challenges]. (United States)

    Dumitrescu, D; Savlovschi, C; Borcan, R; Pantu, H; Serban, D; Gradinaru, S; Smarandache, G; Trotea, T; Branescu, C; Musat, L; Comandasu, M; Priboi, M; Baldir, M; Sandolache, B; Oprescu, S


    We present the case of a 58-year old male patient admitted in the surgery section of the University Emergency Hospital of Bucharest and diagnosed with acute abdomen. The minimal clinical-paraclinical investigation (i.e., thorax-pulmonary Xray, biological probes) raises questions as to the differentiated diagnosis and other associated diseases, also suggesting the existence of voluminous diaphragmatic hernia. The CT thorax-abdomen examination confirms the diaphragmatic hernia suspicion, with intra-thorax ascent of the colon up to the anterior C4 level, but does not explain the abdominal suffering; thus we suspected a biliary ileus or acute appendicitis. Medial laparotomy was imperative. Intrasurgically peritonitis was noticed located by gangrenous acute apendicitis, perforated, with coprolite, for which apendictomy and lavage-drainage pf the peritoneal cavity was performed. Post-surgical status: favourable to recovery.

  12. Acute abdominal pain in patients with lassa fever: Radiological assessment and diagnostic challenges

    Directory of Open Access Journals (Sweden)

    Kenneth C Eze


    Full Text Available Background: To highlight the problems of diagnosis and management of acute abdomen in patients with lassa fever. And to also highlight the need for high index of suspicion of lassa fever in patients presenting with acute abdominal pain in order to avoid surgical intervention with unfavourable prognosis and nosocomial transmission of infections, especially in Lassa fever-endemic regions. Materials and Methods: A review of experiences of the authors in the management of lassa fever over a 4-year period (2004-2008. Literature on lassa fever, available in the internet and other local sources, was studied in November 2010 and reviewed. Results: Normal plain chest radiographic picture can change rapidly due to pulmonary oedema, pulmonary haemorrhage and acute respiratory distress syndrome. Plain abdominal radiograph may show dilated bowels with signs of paralytic ileus or dynamic intestinal obstruction due to bowel wall haemorrhage or inflamed and enlarged Peyer′s patches. Ultrasound may show free intra-peritoneal fluid due to peritonitis and intra-peritoneal haemorrhage. Bleeding into the gall bladder wall may erroneously suggest infective cholecystitis. Pericardial effusion with or without pericarditis causing abdominal pain may be seen using echocardiography. High index of suspicion, antibody testing for lassa fever and viral isolation in a reference laboratory are critical for accurate diagnosis. Conclusion: Patients from lassa fever-endemic regions may present with features that suggest acute abdomen. Radiological studies may show findings that suggest acute abdomen but these should be interpreted in the light of the general clinical condition of the patient. It is necessary to know that acute abdominal pain and vomiting in lassa fever-endemic areas could be caused by lassa fever, which is a medical condition. Surgical option should be undertaken with restraint as it increases the morbidity, may worsen the prognosis and increase the risk of

  13. Mucormycosis Rhinosinusitis at Diagnosis of Acute Lymphoblastic Leukemia: Diagnostics and Management Challenges in a Low-Middle-income Country. (United States)

    Mandegari, Elham; Fu, Ligia; Arambú, Carolina; Montoya, Sandra; Peña, Armando; Johnson, Kyle M; Perfect, John R; Caniza, Miguela A


    We present the case of an adolescent with mucor rhinosinusitis diagnosed concomitantly with acute lymphoblastic leukemia at a hospital in Tegucigalpa, Honduras. We also discuss the challenges faced in the dual management of hematologic malignancies and invasive fungal disease in a low-middle-income country, such as access to diagnostics, immunosuppressants, imaging, and antifungals. Despite these shortcomings, the patient was successfully treated for both the diseases. Low-middle-income country hospitals can effectively treat invasive fungal diseases by providing adequate diagnostic and support services, which can improve the outcomes of pediatric cancer patients.

  14. Acute phase reactants, challenge in the near future of animal production and veterinary medicine

    Institute of Scientific and Technical Information of China (English)


    The future of acute phase proteins (APPs) in science is discussed in this paper. Many functions and associated pathological processes of APPs are unknown. Extrahepatic formation in local tissues needs attention. Local serum amyloid A (SAA) formation may be involved in deposition of AA-amyloid induced by conformational change of SAA resulting in amyloid formation, having tremendous food safety implications. Amyloidogenesis is enhanced in mouse fed beta pleated sheet-rich proteins. The local amyloid in joints of chicken and mammary corpora amylacea is discussed. Differences in glycosylation of glycoproteins among the APPs, as has been shown for α1-acid glycoprotein, have to be considered. More knowledge on the reactivity patterns may lead to implication of APPs in the diagnostics and staging of a disease. Calculation of an index from values of several acute phase variables increases the power of APPs in monitoring unhealthy individuals in animal populations.Vaccinations, just as infections in eliciting acute phase response seem to limit the profitability of vaccines because acute phase reactions are contraproductive in view of muscle anabolism. Interest is focused on amino acid patterns and vitamins in view of dietary nutrition effect on sick and convalescing animals.When inexpensive methodology such as liquid phase methods (nephelometry, turbidimetry) or protein array technology for rapid APPs measurement is available, APPs have a future in routine diagnostics. Specific groups of patients may be screened or populations monitored by using APPs.

  15. Tolerância aguda e crônica de adultos de beta, Betta splendens, à salinidade da água Acute and chronic salinity tolerance in adult siamese fighting fish, Betta splendens

    Directory of Open Access Journals (Sweden)

    Jener Alexandre Sampaio Zuanon


    Full Text Available Com o objetivo de avaliar a tolerância de Betta splendens à salinidade da água, realizou-se um experimento em delineamento inteiramente casualizado, com seis concentrações de sal na água (0; 3; 6; 9; 12 e 15 g de sal comum/L de água, cada uma com cinco repetições (1 peixe/repetição. Fêmeas adultas de Betta splendens foram alojadas individualmente em aquários mantidos em estufa incubadora, a 26 ± 0,2 ºC e fotoperíodo de 12 horas. Os peixes foram alimentados até a saciedade, uma vez ao dia, com ração comercial. Foram mensurados o consumo diário de ração e a sobrevivência dos peixes a cada 12 horas. Para avaliar o efeito agudo da salinidade, foram calculados o tempo médio de sobrevivência e a salinidade letal mediana-96 horas, enquanto o efeito crônico (18 dias foi avaliado pelo cálculo da salinidade máxima de sobrevivência e da salinidade letal mediana. O tempo médio de sobrevivência foi significativamente menor na salinidade de 15 g/L. A salinidade letal mediana-96 horas estimada foi de 11,88 g/L, a salinidade máxima de sobrevivência entre 6 e 7 g/L, e a salinidade letal mediana de 9,35 g/L. Observou-se interação significativa entre as salinidades da água e o tempo de alimentação. Considerando que é uma espécie de água doce, o beta possui alta tolerância à salinidade da água.Salinity tolerance of Betta splendens was evaluated in a complete randomized design, with six salt concentrations in the water (0; 3; 6; 9; 12 and 15 g common salt/L with five replications (1 fish/replication. Adult female B. splendens were individually placed in aquariums in an incubation chamber at 26 ± 0.2ºC and 12-hour photoperiod. Fish were fed to satiation, once a day, with commercial diet. Feed intake and survival rate were measured every 12 hours. To evaluate the effect of acute salinity, the mean survival time and median lethal salinity-96 h were calculated, while the chronic effect (18 days was assessed by calculating

  16. Erythema multiforme due to arsenic trioxide in a case of acute promyelocytic leukemia: A diagnostic challenge

    Directory of Open Access Journals (Sweden)

    Girish V Badarkhe


    Full Text Available Erythema multiforme (EM is an acute, self-limited, Type IV hypersensitivity reactions associated with infections and drugs. In this case of acute promyelocytic leukemia, EM diagnosed during the induction phase was mistakenly attributed to vancomycin used to treat febrile neutropenia during that period. However, the occurrence of the lesions of EM again during the consolidation phase with arsenic trioxide (ATO lead to a re-evaluation of the patient and both the Naranjo and World Health Organization-Uppsala Monitoring Centre scale showed the causality association as “probable.” The rash responded to topical corticosteroids and antihistamines. This rare event of EM being caused by ATO may be attributed to the genetic variation of methyl conjugation in the individual which had triggered the response, and the altered metabolic byproducts acted as a hapten in the subsequent keratinocyte necrosis.

  17. Acute coronary syndromes. Challenging accepted post-MI serum potassium targets. (United States)

    van Diepen, Sean; Granger, Christopher B


    On the basis of high-quality observational data, Goyal et al. have found that serum potassium levels <3.5 mmol/l or ≥4.5 mmol/l are associated with increased in-hospital mortality in patients with acute myocardial infarction. We discuss whether target potassium levels in clinical practice and guidelines should be changed to 3.5–4.5 mmol/l.


    Directory of Open Access Journals (Sweden)

    A. I. Sushkov


    Full Text Available Diagnostic criteria and treatment protocols for acute antibody-mediated rejection (AMR of kidney allograft remain controversial. We report the case of early severe AMR after primary kidney transplantation. The graft removal was considered in the absence of treatment efficacy and in the presence of systemic infl ammatory response syndrome. However, at surgery the graft looked normal and it was not removed. The repeated treatment course (plasmapheresis, antithymocyte globulin, intravenous immunoglobulin and rituximab was effective. The patient has good and stable graft function in 1 year after transplantation. 

  19. Acute myeloid dendritic cell leukaemia with specific cutaneous involvement: a diagnostic challenge. (United States)

    Ferran, M; Gallardo, F; Ferrer, A M; Salar, A; Pérez-Vila, E; Juanpere, N; Salgado, R; Espinet, B; Orfao, A; Florensa, L; Pujol, R M


    Myeloid or type 1 dendritic cell leukaemia is an exceedingly rare haematopoietic neoplasm characterized by a specific immunophenotypic profile close to plasmacytoid dendritic cell and acute myelogenous leukaemia. A 77-year-old man presenting specific cutaneous infiltration by myeloid dendritic cell leukaemia is reported. The clinical features as well as the cutaneous histopathological and immunohistochemical features led to the initial diagnosis of CD4+/CD56+ haematodermic neoplasm. However, extensive immunophenotypic studies performed from peripheral blood blasts disclosed that leukaemic cells expressed myeloid dendritic cell markers, confirming the diagnosis. The diagnostic difficulties of specific cutaneous involvement by myeloid dendritic cell leukaemia on the basis of routine histopathological and immunohistochemical features are highlighted.

  20. Saline agriculture in Mediterranean environments

    Directory of Open Access Journals (Sweden)

    Albino Maggio


    Full Text Available Salinization is increasingly affecting world's agricultural land causing serious yield loss and soil degradation. Understanding how we could improve crop productivity in salinized environments is therefore critical to meet the challenging goal of feeding 9.3 billion people by 2050. Our comprehension of fundamental physiological mechanisms in plant salt stress adaptation has greatly advanced over the last decades. However, many of these mechanisms have been linked to salt tolerance in simplified experimental systems whereas they have been rarely functionally proven in real agricultural contexts. In-depth analyses of specific crop-salinity interactions could reveal important aspects of plant salt stress adaptation as well as novel physiological/agronomic targets to improve salinity tolerance. These include the developmental role of root vs. shoot systems respect to water-ion homeostasis, morphological vs. metabolic contributions to stress adaptation, developmental processes vs. seasonal soil salinity evolution, residual effects of saline irrigation in non-irrigated crops, critical parameters of salt tolerance in soil-less systems and controlled environments, response to multiple stresses. Finally, beneficial effects of salinization on qualitative parameters such as stress-induced accumulation of high nutritional value secondary metabolites should be considered, also. In this short review we attempted to highlight the multifaceted nature of salinity in Mediterranean agricultural systems by summarizing most experimental activity carried out at the Department of Agricultural Engineering and Agronomy of University of Naples Federico II in the last few years.

  1. Impact of nutrition and salinity changes on biological performances of green and white sturgeon. (United States)

    Vaz, Pedro G; Kebreab, Ermias; Hung, Silas S O; Fadel, James G; Lee, Seunghyung; Fangue, Nann A


    Green and white sturgeon are species of high conservational and economic interest, particularly in the San Francisco Bay Delta (SFBD) for which significant climate change-derived alterations in salinity and nutritional patterns are forecasted. Although there is paucity of information, it is critical to test the network of biological responses underlying the capacity of animals to tolerate current environmental changes. Through nutrition and salinity challenges, climate change will likely have more physiological effect on young sturgeon stages, which in turn may affect growth performance. In this study, the two species were challenged in a multiple-factor experimental setting, first to levels of feeding rate, and then to salinity levels for different time periods. Data analysis included generalized additive models to select predictors of growth performance (measured by condition factor) among the environmental stressors considered and a suite of physiological variables. Using structural equation modeling, a path diagram is proposed to quantify the main linkages among nutrition status, salinity, osmoregulation variables, and growth performances. Three major trends were anticipated for the growth performance of green and white sturgeon in the juvenile stage in the SFBD: (i) a decrease in prey abundance will be highly detrimental for the growth of both species; (ii) an acute increase in salinity within the limits studied can be tolerated by both species but possibly the energy spent in osmoregulation may affect green sturgeon growth within the time window assessed; (iii) the mechanism of synergistic effects of nutrition and salinity changes will be more complex in green sturgeon, with condition factor responding nonlinearly to interactions of salinity and nutrition status or time of salinity exposure. Green sturgeon merits special scientific attention and conservation effort to offset the effects of feed restriction and salinity as key environmental stressors in the

  2. Impact of nutrition and salinity changes on biological performances of green and white sturgeon.

    Directory of Open Access Journals (Sweden)

    Pedro G Vaz

    Full Text Available Green and white sturgeon are species of high conservational and economic interest, particularly in the San Francisco Bay Delta (SFBD for which significant climate change-derived alterations in salinity and nutritional patterns are forecasted. Although there is paucity of information, it is critical to test the network of biological responses underlying the capacity of animals to tolerate current environmental changes. Through nutrition and salinity challenges, climate change will likely have more physiological effect on young sturgeon stages, which in turn may affect growth performance. In this study, the two species were challenged in a multiple-factor experimental setting, first to levels of feeding rate, and then to salinity levels for different time periods. Data analysis included generalized additive models to select predictors of growth performance (measured by condition factor among the environmental stressors considered and a suite of physiological variables. Using structural equation modeling, a path diagram is proposed to quantify the main linkages among nutrition status, salinity, osmoregulation variables, and growth performances. Three major trends were anticipated for the growth performance of green and white sturgeon in the juvenile stage in the SFBD: (i a decrease in prey abundance will be highly detrimental for the growth of both species; (ii an acute increase in salinity within the limits studied can be tolerated by both species but possibly the energy spent in osmoregulation may affect green sturgeon growth within the time window assessed; (iii the mechanism of synergistic effects of nutrition and salinity changes will be more complex in green sturgeon, with condition factor responding nonlinearly to interactions of salinity and nutrition status or time of salinity exposure. Green sturgeon merits special scientific attention and conservation effort to offset the effects of feed restriction and salinity as key environmental


    Parilova, O O; Shandrenko, S G


    An immunoregulatory role of nitric oxide (NO) in the development of adaptive immune responses associated with allergic diseases is very important. The present study extended these observations by the examination of the reciprocal changes in characteristic immunologic parameters of the disease and NO level of bronchoalveolar lavage (BAL) cells under guinea pig model of acute asthma with multiple challenges. Development of guinea pig Th2 mediated asthma was accompanied by increasing the level of allergic markers: ovalbumin (OVA) specific IgG and IL-4. We demonstrated that the infiltrate of airway cells contributes to NO synthesis in the respiratory tract during allergic inflammation. The level of intracellular NO formation significantly correlated with plasma allergen specific IgG value in OVA-induced asthma. The presented data evidence that the elevated intracellular NO level in BAL fluid may reflect a nitrosative stress in respiratory tract in general, when allergic asthma exacerbation is present.

  4. Decontamination of multiple casualties who are chemically contaminated: a challenge for acute hospitals. (United States)

    Clarke, Simon F J; Chilcott, Rob P; Wilson, James C; Kamanyire, Robie; Baker, David J; Hallett, Anthony


    Patients who have been contaminated by chemical compounds present a number of difficulties to emergency departments, in particular, the risk of secondary contamination of healthcare staff and facilities. The Department of Health in the United Kingdom has provided equipment to decontaminate chemically contaminated casualties who present at emergency departments. The capacity of this equipment is limited, and although both the ambulance and fire services have equipment to cope with mass casualties at the scene of a chemical incident, there is still the possibility that acute hospitals will be overwhelmed by large numbers of self-presenting patients. The risks and potential consequences of this gap in resilience are discussed and a number of possible practical solutions are proposed.

  5. Diagnostic challenges of Wilson's disease presenting as acute pancreatitis, cholangitis, and jaundice. (United States)

    Nussinson, Elchanan; Shahbari, Azmi; Shibli, Fahmi; Chervinsky, Elena; Trougouboff, Philippe; Markel, Arie


    Wilson's disease is a rare disorder of copper transport in hepatic cells, and may present as cholestatic liver disease; pancreatitis and cholangitis are rarely associated with Wilsons's disease. Moreover, cases of Wilson's disease presenting as pigmented gallstone pancreatitis have not been reported in the literature. In the present report, we describe a case of a 37-year-old man who was admitted with jaundice and abdominal pain. The patient was diagnosed with acute pancreatitis, cholangitis, and obstructive jaundice caused by pigmented gallstones that were detected during retrograde cholangiopancreatography. However, because of his long-term jaundice and the presence of pigmented gallstones, the patient underwent further evaluation for Wilson's disease, which was subsequently confirmed. This patient's unique presentation exemplifies the overlap in the clinical and laboratory parameters of Wilson's disease and cholestasis, and the difficulties associated with their differentiation. It suggests that Wilson's disease should be considered in patients with pancreatitis, cholangitis, and severe protracted jaundice caused by pigmented gallstones.

  6. Acute triventricular hydrocephalus caused by choroid plexus cysts: a diagnostic and neurosurgical challenge. (United States)

    Spennato, Pietro; Chiaramonte, Carmela; Cicala, Domenico; Donofrio, Vittoria; Barbarisi, Manlio; Nastro, Anna; Mirone, Giuseppe; Trischitta, Vincenzo; Cinalli, Giuseppe


    OBJECTIVE Intraventricular choroid plexus cysts are unusual causes of acute hydrocephalus in children. Radiological diagnosis of intraventricular choroid plexus cysts is difficult because they have very thin walls and fluid contents similar to CSF and can go undetected on routine CT studies. METHODS This study reports the authors' experience with 5 patients affected by intraventricular cysts originating from the choroid plexus. All patients experienced acute presentation with rapid neurological deterioration, sometimes associated with hypothalamic dysfunction, and required urgent surgery. In 2 cases the symptoms were intermittent, with spontaneous remission and sudden clinical deteriorations, reflecting an intermittent obstruction of the CSF pathway. RESULTS Radiological diagnosis was difficult in these cases because a nonenhanced CT scan revealed only triventricular hydrocephalus, with slight lateral ventricle asymmetry in all cases. MRI with driven-equilibrium sequences and CT ventriculography (in 1 case) allowed the authors to accurately diagnose the intraventricular cysts that typically occupied the posterior part of the third ventricle, occluding the aqueduct and at least 1 foramen of Monro. The patients were managed by urgent implantation of an external ventricular drain in 1 case (followed by endoscopic surgery, after completing a diagnostic workup) and by urgent endoscopic surgery in 4 cases. Endoscopic surgery allowed the shrinkage and near-complete removal of the cysts in all cases. Use of neuronavigation and a laser were indispensable. All procedures were uneventful, resulting in restoration of normal neurological conditions. Long-term follow-up (> 2 years) was available for 2 patients, and no complications or recurrences occurred. CONCLUSIONS This case series emphasizes the necessity of an accurate and precise identification of the possible causes of triventricular hydrocephalus. Endoscopic surgery can be considered the ideal treatment of choroid plexus

  7. Efficacy and tolerability of an ectoine mouth and throat spray compared with those of saline lozenges in the treatment of acute pharyngitis and/or laryngitis: a prospective, controlled, observational clinical trial. (United States)

    Müller, Dörte; Lindemann, Torben; Shah-Hosseini, Kija; Scherner, Olaf; Knop, Markus; Bilstein, Andreas; Mösges, Ralph


    The aim of this observational trial was to evaluate the efficacy and tolerability of a mouth and throat spray containing ectoine in the treatment of acute pharyngitis and/or laryngitis. The outcome was compared with control treatment using saline lozenges. This study was designed as a prospective, controlled, non-randomized, observational multicenter clinical trial and was conducted in Germany. The study population consisted of 95 patients. The decision for treatment with either spray or lozenges was based on the patients' preference for pharyngeal or oral application. Investigators assessed symptoms specific to acute pharyngitis/laryngitis and determined the pharyngitis symptom score. Both patients and investigators evaluated the tolerability and efficacy of the treatment applied. Treatment with the spray showed higher efficacy, 1.95 ± 0.81 versus 1.68 ± 0.67 (investigators) and 1.97 ± 0.88 versus 1.57 ± 0.69 (patients, p ectoine-based spray showed superior efficacy in treating acute pharyngitis and/or laryngitis.

  8. Immunomodulatory properties of gamithromycin and ketoprofen in lipopolysaccharide-challenged calves with emphasis on the acute-phase response. (United States)

    Plessers, Elke; Wyns, Heidi; Watteyn, Anneleen; Pardon, Bart; De Baere, Siegrid; Sys, Stanislas U; De Backer, Patrick; Croubels, Siska


    Macrolide antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs) have been reported to be modulators of the innate immune response, irrespectively of their antimicrobial and anti-inflammatory actions. Therefore, it was our objective to evaluate whether the macrolide gamithromycin (GAM) and the NSAID ketoprofen (KETO) attenuate the acute-phase response in calves, and whether their combined administration is beneficial due to synergistic and/or additive effects. To this end, both drugs, as well as their combination, were studied in a previously developed inflammation model, i.e., the induction of an acute-phase response by an intravenous lipopolysaccharide (LPS) challenge (0.5 μg/kg body weight). Sixteen 4-week-old Holstein-Friesian calves were randomized into 4 groups: a positive control (+CONTR) group, receiving LPS but no pharmacological treatment (n=4) and a GAM (n=4), a KETO (n=4) and a GAM-KETO (n=4) group, receiving the respective drugs 1h prior to LPS administration. Clinical scoring and blood collection were performed at regular time points until 72 h post LPS challenge. Plasma concentrations of the selected cytokines (tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6)), acute-phase protein (serum amyloid A (SAA)) and prostaglandin E2 (PGE2) were subsequently quantified. Pre-treatment with GAM had no effect in the inflammation model compared to the +CONTR group. KETO, on the other hand, completely inhibited depression, anorexia and fever. This remarkable influence was associated with a significant reduction of PGE2 synthesis by KETO, while the effect on TNF-α, IL-6 and SAA was not straightforward. The combined administration of GAM and KETO provided no synergistic or additive effects in this model, neither clinically nor regarding the studied inflammatory mediators. In conclusion, KETO entirely inhibited PGE2 synthesis, fever development and depression, while GAM did not exert any effect in this model. These results promote the concomitant

  9. The Epistemological and Didactical Challenges Involved in Teaching Socially Acute Questions. The Example of Globalization

    Directory of Open Access Journals (Sweden)

    Jean Simonneaux


    Full Text Available Teachers are being asked to manage a specific didactic situation which falls into the category of what we have proposed to call “socially acute questions (SAQs”. A SAQ is a question which is acute in society, in background knowledge and in knowledge taught. Thus, teaching SAQs demands socio-epistemological reflexivity in the processes of knowledge production and in the social conditions in which this knowledge emerges; teaching SAQs will give priority to interdisciplinary, scientific and ethical reasoning. The split between ideology and science can certainly be examined when considering a socially acute question which is the subject of debate in society. In the example of the globalization taught: the diversity of analysis in the economic domain gives rise to great uncertainty because it justifies practically opposing policies; within a transdisciplinary framework, the globalization includes concepts, ideologies or social practices in a double movement of standardization and differentiation. By way of SAQs, we have attempted to show that learning stakes are numerous. However didactic choices must be supported by socio-epistemological survey, the identification of an epistemological posture and the definition of a didactic strategy.Les enseignants sont appelés à gérer une situation didactique spécifique dans l’enseignement des «questions socialement vives (QSV ». Les QSV sont des questions qui donnent lieu à débat dans la société, dans les savoirs scientifiques et dans l’enseignement. Ainsi, l‘enseignement des QSV nécessite une réflexivité socio-épistémologique dans le processus de production du savoir et dans les conditions sociales d’émergence de ces savoirs; l’enseignement des QSV donnera la priorité au raisonnement interdisciplinaire, scientifique et éthique. La scission entre l‘idéologie et la science peut être examinée lors de l‘examen d‘une QSV qui fait l‘objet d‘un débat dans la soci

  10. Cardioprotection and pharmacological therapies in acute myocardial infarction: Challenges in the current era. (United States)

    Dominguez-Rodriguez, Alberto; Abreu-Gonzalez, Pedro; Reiter, Russel J


    In patients with an acute ST-segment elevation myocardial infarction, timely myocardial reperfusion using primary percutaneous coronary intervention is the most effective therapy for limiting myocardial infarct size, preserving left-ventricular systolic function and reducing the onset of heart failure. Within minutes after the restoration of blood flow, however, reperfusion itself results in additional damage, also known as myocardial ischemia-reperfusion injury. An improved understanding of the pathophysiological mechanisms underlying reperfusion injury has resulted in the identification of several promising pharmacological (cyclosporin-A, exenatide, glucose-insulin-potassium, atrial natriuretic peptide, adenosine, abciximab, erythropoietin, metoprolol and melatonin) therapeutic strategies for reducing the severity of myocardial reperfusion injury. Many of these agents have shown promise in initial proof-of-principle clinical studies. In this article, we review the pathophysiology underlying myocardial reperfusion injury and highlight the potential pharmacological interventions which could be used in the future to prevent reperfusion injury and improve clinical outcomes in patients with coronary heart disease.

  11. Acute human brain responses to intracortical microelectrode arrays: Challenges and future prospects

    Directory of Open Access Journals (Sweden)

    Eduardo eFernandez


    Full Text Available The emerging field of neuroprosthetics is focused on the development of new therapeutic interventions that will be able to restore some lost neural function by selective electrical stimulation or by harnessing activity recorded from populations of neurons. As more and more patients benefit from these approaches, the interest in neural interfaces has grown significantly and a new generation of penetrating microelectrode arrays are providing unprecedented access to the neurons of the CNS. These microelectrodes have active tip dimensions that are similar in size to neurons and because they penetrate the nervous system, they provide selective access to these cells (within a few microns. However, the very long-term viability of chronically implanted microelectrodes and the capability of recording the same spiking activity over long time periods still remain to be established and confirmed in human studies. Here we review the main responses to acute implantation of microelectrode arrays, and emphasize that it will become essential to control the neural tissue damage induced by these intracortical microelectrodes in order to achieve the high clinical potentials accompanying this technology.

  12. Testicular relapse in childhood acute lymphoblastic leukemia: The challenges and lessons

    Directory of Open Access Journals (Sweden)

    K P Kulkarni


    Full Text Available Background : Relapse of disease is documented in 15-20% of children with acute lymphoblastic leukemia (ALL. Although testicular relapse is rare with modern risk-adapted treatment protocols, earlier, the testes were a frequently encountered site of relapse and were designated as "drug sanctuaries". Purpose : This descriptive study was designed to assess the pattern of testicular relapse and to identify high-risk factors. Materials and Methods : Data obtained from case records of 407 boys with ALL were analyzed. Fine needle aspiration cytology was carried out in children presenting with painless enlargement of testi(es. Bone marrow aspiration and cerebrospinal fluid examination were performed concomitantly to confirm or exclude disease at these sites. Results : Testicular relapse was documented in 30 boys. It was isolated in 17 patients and associated with bone marrow and/or central nervous system relapse in 13. At relapse, nine boys were over the age of 10 years. The majority were very early and early relapsers. Hyperleucocytosis was documented in five of 30 and seven of 137 relapsers and nonrelapsers, respectively (P = 0.04. Twelve of the 30 boys with testicular relapse were treated with testicular irradiation, reinduction and maintenance therapy. The estimated median overall survival was 33 months. Conclusion : Testicular relapse, which depends on the therapy administered, may manifest several months/years after completion of treatment. The high incidence of testicular relapse in our series implicates the need of revaluation of our protocol and incorporation of high/intermediate dose methotrexate therapy upfront.

  13. Neutrophil engagement and septic challenge in acute experimental pancreatitis in rats

    Institute of Scientific and Technical Information of China (English)

    Stanislaw Ha(c); Marek Dobosz; Jan J Kaczor; Robert Rzepko; Ewa Aleksandrowicz-Wrona; Zdzis(l)aw Wajda; Zbigniew (S)ledziński; Jacek Krajewski


    AIM: To investigate the influence of neutrophil adhesion molecule blockade with monoclonal antibody (MoAb CD11b) and E. coli lipopolysaccharide (LPS)administration on experimental acute pancreatitis (AP).METHODS: AP was induced by four ip injections of cerulein (Cn) at 1-h intervals. MoAb CD 11b and LPS were administered at the beginning of the experiment.RESULTS: The neutrophil count and chemiluminescence were diminished at the beginning of AP. The oxidative stress parameters were found within the pancreatic gland. MoAb CD 11b used for AP resulted in a significant reduction of pancreatic infiltration and pancreatitis oxidative stress parameters. Serum interleukin-6 (IL-6)was not detected in AP animals, whereas high serum IL-6 concentration was noted only in animals receiving LPS.CONCLUSION: Neutrophils are involved in pancreatic damage in the early stage of AP. Neutrophil infiltration reduction protects the pancreatic gland from destruction during AP. LPS does not change the early course of Cn pancreatitis in rats.

  14. Estimation of genetic parameters and genotype-by-environment interactions related to acute ammonia stress in Pacific white shrimp (Litopenaeus vannamei) juveniles at two different salinity levels (United States)

    Lu, Xia; Luan, Sheng; Cao, Baoxiang; Meng, Xianhong; Sui, Juan; Dai, Ping; Luo, Kun; Shi, Xiaoli; Hao, Dengchun; Han, Guomin; Kong, Jie


    Regarding the practical farming of Litopenaeus vannamei, the deterioration of water quality from intensive culture systems and environmental pollution is a common but troublesome problem in the cultivation of this species. The toxicities that result from deteriorating water quality, such as that from ammonia stress, have lethal effects on juvenile shrimp and can increase their susceptibility to pathogens. The toxicity of ammonia plays an important role in the frequently high mortality during the early stage on shrimp farms. However, little information is available regarding the genetic parameters of the ammonia tolerance of juveniles in the early stage, but this information is necessary to understand the potential for the genetic improvement of this trait. Considering the euryhalinity of L. vannamei and the fact that low salinity can increase the toxicity of ammonia stress, we estimated the heritability of ammonia tolerance in juveniles in 30‰ (normal) and 5‰ (low) salinity in this study using the survival time (ST) at individual level and the survival status at the half-lethal time (SS50) at the family level. In the normal and low salinity conditions and for the merged data, the heritability estimates of the ST (0.784±0.070, 0.575±0.068, and 0.517±0.058, respectively) and SS50 (0.402±0.061, 0.216±0.050, and 0.264±0.050, respectively) were all significantly greater than zero, which indicates that the ammonia-tolerance of shrimp can be greatly improved. So it might provide an alternative method to reduce mortality, help to enhance resistance to pathogens and reduce the occurrence of infectious diseases. The significant positive genetic correlation between ST and body length suggested that ammonia is more toxic to shrimp in the early stage. The medium-strength genetic correlations of the ST and SS50 between the two environments (0.394±0.097 and 0.377±0.098, respectively) indicate a strong genotype-by-environment (G×E) interaction for ammonia tolerance

  15. Successful vaccination strategies that protect aged mice from lethal challenge from influenza virus and heterologous severe acute respiratory syndrome coronavirus. (United States)

    Sheahan, Timothy; Whitmore, Alan; Long, Kristin; Ferris, Martin; Rockx, Barry; Funkhouser, William; Donaldson, Eric; Gralinski, Lisa; Collier, Martha; Heise, Mark; Davis, Nancy; Johnston, Robert; Baric, Ralph S


    Newly emerging viruses often circulate as a heterogeneous swarm in wild animal reservoirs prior to their emergence in humans, and their antigenic identities are often unknown until an outbreak situation. The newly emerging severe acute respiratory syndrome coronavirus (SARS-CoV) and reemerging influenza virus cause disproportionate disease in the aged, who are also notoriously difficult to successfully vaccinate, likely due to immunosenescence. To protect against future emerging strains, vaccine platforms should induce broad cross-reactive immunity that is sufficient to protect from homologous and heterologous challenge in all ages. From initial studies, we hypothesized that attenuated Venezuelan equine encephalitis virus (VEE) replicon particle (VRP) vaccine glycoproteins mediated vaccine failure in the aged. We then compared the efficacies of vaccines bearing attenuated (VRP(3014)) or wild-type VEE glycoproteins (VRP(3000)) in young and aged mice within novel models of severe SARS-CoV pathogenesis. Aged animals receiving VRP(3000)-based vaccines were protected from SARS-CoV disease, while animals receiving the VRP(3014)-based vaccines were not. The superior protection for the aged observed with VRP(3000)-based vaccines was confirmed in a lethal influenza virus challenge model. While the VRP(3000) vaccine's immune responses in the aged were sufficient to protect against lethal homologous and heterologous challenge, our data suggest that innate defects within the VRP(3014) platform mediate vaccine failure. Exploration into the mechanism(s) of successful vaccination in the immunosenescent should aid in the development of successful vaccine strategies for other viral diseases disproportionately affecting the elderly, like West Nile virus, influenza virus, norovirus, or other emerging viruses of the future.

  16. Challenges in implementing individualized medicine illustrated by antimetabolite therapy of childhood acute lymphoblastic leukemia

    DEFF Research Database (Denmark)

    Nersting, Jacob; Borst, Louise; Schmiegelow, Kjeld


    of acceptable toxicity, an individualized therapeutic approach is indicated. The mapping of the human genome and technological developments in DNA sequencing, gene expression profiling, and proteomics have raised the expectations for implementing genotype-phenotype data into the clinical decision process......, but also multiplied the complex interaction of genetic and other laboratory parameters that can be used for therapy adjustments. Thus, with the advances in the laboratory techniques, post laboratory issues have become major obstacles for treatment individualization. Many of these challenges have been...... or single gene response data that often vary across treatment protocols, iii) combining disease and host genomics with outcome variations, and iv) physicians' reluctance in implementing potentially useful genotype and phenotype data into clinical practice, since unjustified downward or upward dose...

  17. Clinical Observation of Hypertonic Saline in Treatment of Acute Massive Cerebral Infarction%高渗盐水治疗急性期大面积脑梗死的临床观察

    Institute of Scientific and Technical Information of China (English)

    黄德; 谢向前; 蒙泽明; 李忠


    目的:探讨高渗盐水治疗急性期大面积脑梗死脑水肿的临床疗效。方法:选取本院神经内科收治的急性期大面积脑梗死脑水肿患者46例,所有患者均经头颅CT或MRI检查确诊。按随机数字表法将患者分为两组,每组各23例。观察组(高渗盐水组)使用3%高渗盐水进行脱水治疗,对照组(甘露醇组)使用20%甘露醇进行脱水治疗,比较两组患者治疗前和治疗后神经功能缺损程度(MESSS评分)以及血钠、血钾、血肌酐、血浆渗透压的改变。结果:两组治疗后第3天和第5天后神经功能缺损程度均较前减轻(P0.05),对照组治疗5 d后出现血钾偏低4例,血肌酐升高伴少尿(急性肾功能不全)1例。结论:3%高渗盐水治疗急性期大面积脑梗死脑水肿疗效确切,不良反应少,值得临床进一步研究和推广应用。%Objective:To investigate the clinical efficacy of hypertonic saline in treatment of acute massive cerebral infarction.Method:46 patients with acute massive cerebral infarction treated in the neurology department of our hospital were selected,all patients were diagnosed by CT or MRI,and the 46 patients were randomly divided into two groups,23 in each group,the observation group(hypertonic saline group)using 3%hypertonic saline for dehydration treatment,the control group(mannitol group)with 20% mannitol dehydration treatment,the degree of neurological impairment(MESSS score )and the change of the blood sodium,potassium,creatinine ,plasma osmolality was observed in both groups of patients before treatment and after treatment. Result:Three and five days after treatment,the degree of neurological impairment(MESSS score)in both groups of patients were reduced(P0.05),while in the control group,four cases appear low potassium,one case of elevated serum creatinine with oliguria(acute renal failure). Conclusion:The efficacy of 3%hypertonic saline in treatment of acute massive

  18. Silicon Deprivation Does Not Significantly Modify the Acute White Blood Cell Response but Does Modify Tissue Mineral Distribution Response to an Endotoxin Challenge (United States)

    An experiment with rats was conducted to determine whether silicon deprivation affects the acute-phase immune response to an endotoxin challenge. Weanling female rats were assigned to two weight-matched groups of 24; one group was fed a basal diet containing about 1.9 µg Si/kg, the other group was f...

  19. Saline Valley (United States)


    [figure removed for brevity, see original site] [figure removed for brevity, see original site] Figure 1 Figure 2 These images of the Saline Valley area, California, were acquired March 30, 2000 and cover a full ASTER scene (60 by 60 km). Each image displays data from a different spectral region, and illustrates the complementary nature of surface compositional information available as a function of wavelength. This image displays visible and near infrared bands 3, 2, and 1 in red, green, and blue (RGB). Vegetation appears red, snow and dry salt lakes are white, and exposed rocks are brown, gray, yellow and blue. Rock colors mainly reflect the presence of iron minerals, and variations in albedo. Figure 1 displays short wavelength infrared bands 4, 6, and 8 as RGB. In this wavelength region, clay, carbonate, and sulfate minerals have diagnostic absorption features, resulting in distinct colors on the image. For example, limestones are yellow-green, and purple areas are kaolinite-rich. Figure 2 displays thermal infrared bands 13, 12 and 10 as RGB. In this wavelength region, variations in quartz content appear as more or less red; carbonate rocks are green, and mafic volcanic rocks are purple. The image is located at 36.8 degrees north latitude and 117.7 degrees west longitude. The U.S. science team is located at NASA's Jet Propulsion Laboratory, Pasadena, Calif. The Terra mission is part of NASA's Science Mission Directorate.

  20. Tilapia (Oreochromis mossambicus) brain cells respond to hyperosmotic challenge by inducing myo-inositol biosynthesis. (United States)

    Gardell, Alison M; Yang, Jun; Sacchi, Romina; Fangue, Nann A; Hammock, Bruce D; Kültz, Dietmar


    This study aimed to determine the regulation of the de novo myo-inositol biosynthetic (MIB) pathway in Mozambique tilapia (Oreochromis mossambicus) brain following acute (25 ppt) and chronic (30, 60 and 90 ppt) salinity acclimations. The MIB pathway plays an important role in accumulating the compatible osmolyte, myo-inositol, in cells in response to hyperosmotic challenge and consists of two enzymes, myo-inositol phosphate synthase and inositol monophosphatase. In tilapia brain, MIB enzyme transcriptional regulation was found to robustly increase in a time (acute acclimation) or dose (chronic acclimation) dependent manner. Blood plasma osmolality and Na(+) and Cl(-) concentrations were also measured and significantly increased in response to both acute and chronic salinity challenges. Interestingly, highly significant positive correlations were found between MIB enzyme mRNA and blood plasma osmolality in both acute and chronic salinity acclimations. Additionally, a mass spectrometry assay was established and used to quantify total myo-inositol concentration in tilapia brain, which closely mirrored the hyperosmotic MIB pathway induction. Thus, myo-inositol is a major compatible osmolyte that is accumulated in brain cells when exposed to acute and chronic hyperosmotic challenge. These data show that the MIB pathway is highly induced in response to environmental salinity challenge in tilapia brain and that this induction is likely prompted by increases in blood plasma osmolality. Because the MIB pathway uses glucose-6-phosphate as a substrate and large amounts of myo-inositol are being synthesized, our data also illustrate that the MIB pathway likely contributes to the high energetic demand posed by salinity challenge.

  1. Comparative time-course study on pituitary and branchial response to salinity challenge in Mozambique tilapia (Oreochromis mossambicus) and Nile tilapia (O. niloticus). (United States)

    Velan, Ariel; Hulata, Gideon; Ron, Micha; Cnaani, Avner


    The physiological response of Mozambique and Nile tilapia transferred from fresh to brackish (15 ppt) water was compared during a one-week time course. Response in the pituitary was measured by the gene expression pattern of prolactin (PRL I), growth hormone (GH), and calcium-sensing receptor (CaSR), while the response in the gills was measured by the gene expression pattern of the prolactin receptor (PRL-R), Na(+)/K(+)/2Cl(-) cotransporter (NKCC) and Na(+)/Cl(-) cotransporter (NCC), and by activity and expression of Na(+)/K(+)-ATPase (NKA). The time-course curves of plasma osmolality levels indicate a rapid elevation 24 h after transfer, which later decreased and maintained at stable level. PRL I expression decreased in both species, but with stronger response in the Nile tilapia, while no differences were found in the slightly elevated levels of GH mRNA. The branchial response demonstrated a faster up-regulation of NKA and NKCC in the Mozambique tilapia, but similar levels after a week, while Nile tilapia had stronger and constant down-regulation of NCC. The time-course response of the measured osmoregulatory parameters indicate that 24 h after transfer is a critical time point for brackish-water adaptation. The differences in responses to saltwater challenge between Mozambique and Nile tilapia shown in this study may be associated with the differences in saltwater tolerance between these two tilapiine species.

  2. The Challenge of Managing Fusiform Basilar Artery Aneurysms: From Acute Ischemic Stroke to a Massive Subarachnoid Hemorrhage

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    Sofia Bezerra


    Full Text Available We present the case of a patient with acute brain stem ischemic stroke who was found to have a fusiform basilar aneurysm with a thrombus within the dilated vessel. Three days after the ischemic stroke, the patient had a massive subarachnoid hemorrhage and died. This case illustrates the difficulties in the acute management of ischemic events in patients with basilar fusiform aneurysms, because the natural history of this disease encompasses both bleeding and thrombosis.

  3. Effects of a Dissostichus mawsoni-CaM recombinant proteins feed additive on the juvenile orange-spotted grouper (Epinephelus coioides) under the acute low temperature challenge. (United States)

    Luo, Sheng-Wei; Wang, Wei-Na; Cai, Luo; Qi, Zeng-Hua; Wang, Cong; Liu, Yuan; Peng, Chang-Lian; Chen, Liang-Biao


    The effects of Dissostichus mawsoni-Calmodulin (Dm-CaM) on growth performance, enzyme activities, respiratory burst, MDA level and immune-related gene expressions of the orange-spotted grouper (Epinephelus coioides) exposed to the acute low temperature stress were evaluated. The commercial diet supplemented with Dm-CaM protein was fed to the groupers for 6 weeks. No significant difference was observed in the specific growth rates, weight gains and survivals. After the feeding trial, the groupers were exposed to acute low temperature challenge. The groupers fed with Dm-CaM additive diet showed a significant decrease in the respiratory burst activity, while the blood cell number increased significantly at 25 °C by comparing with the control and additive control group. The enzymatic activity of SOD, ACP and ALP increased significantly in Dm-CaM additive group, while MDA level maintained stable with the lowest value. qRT-PCR analysis indicated that the up-regulated transcript expressions of CaM, C3, SOD2, LysC and HSPA4 were observed in Dm-CaM additive group. These results indicated that Dm-CaM additive diet may regulate the grouper immune response to the acute low temperature challenge.

  4. Effects of pathogenic bacterial challenge after acute sublethal ammonia-N exposure on heat shock protein 70 expression in Botia reevesae. (United States)

    Qin, Chuanjie; Zhao, Daxian; Gong, Quan; Qi, Zemin; Zou, Yuanchao; Yue, Xingjian; Xie, Biwen


    The objective of this study was to investigate the effects of pathogenic bacterial challenge after acute sublethal ammonia-N exposure on heat shock protein 70 expression in Botia reevesae. After ammonia-N exposure at a constant concentration of 7.21 ± 0.10 mg L(-1) for 96 h, B. reevesae was challenged with Aeromonas hydrophila. Quantitative PCR analysis showed predominant and significant expression of HSP70 in liver, gill, skin, spleen and kidney (P ammonia-N exposure and A. hydrophila challenge. Furthermore, following A. hydrophila challenge after ammonia-N exposure, HSP70 mRNA expression was significantly upregulated in kidney and gill tissues, although its expression levels were significantly lower than those detected following A. hydrophila challenge or ammonia-N exposure individually. These results indicate that B. reevesae HSP70 is involved in resistance to pathogenic bacteria. It is hypothesized that ammonia-N results in the downregulation of HSP70 mRNA in immune organs after an A. hydrophila challenge, thus lowering their resistance to pathogenic stress.

  5. Measuring Salinity by Conductivity. (United States)

    Lapworth, C. J.


    Outlines procedures for constructing an instrument which uses an electrode and calibration methods to measure the salinity of waters in environments close to and affected by a saline estuary. (Author/DC)

  6. A European pharmaceutical company initiative challenging the regulatory requirement for acute toxicity studies in pharmaceutical drug development. (United States)

    Robinson, Sally; Delongeas, Jean-Luc; Donald, Elizabeth; Dreher, David; Festag, Matthias; Kervyn, Sophie; Lampo, Ann; Nahas, Kamil; Nogues, Vicente; Ockert, Deborah; Quinn, Kirsty; Old, Sally; Pickersgill, Nigel; Somers, Kev; Stark, Claudia; Stei, Peter; Waterson, Lynne; Chapman, Kathryn


    Regulatory guidelines indicate acute toxicity studies in animals are considered necessary for pharmaceuticals intended for human use. This is the only study type where lethality is mentioned as an endpoint. The studies are carried out, usually in rodents, to support marketing of new drugs and to identify the minimum lethal dose. A European initiative including 18 companies has undertaken an evidence-based review of acute toxicity studies and assessed the value of the data generated. Preclinical and clinical information was shared on 74 compounds. The analysis indicated acute toxicity data was not used to (i) terminate drugs from development (ii) support dose selection for repeat dose studies in animals or (iii) to set doses in the first clinical trials in humans. The conclusion of the working group is that acute toxicity studies are not needed prior to first clinical trials in humans. Instead, information can be obtained from other studies, which are performed at more relevant doses for humans and are already an integral part of drug development. The conclusions have been discussed and agreed with representatives of regulatory bodies from the US, Japan and Europe.

  7. Acute infection with venezuelan equine encephalitis virus replicon particles catalyzes a systemic antiviral state and protects from lethal virus challenge. (United States)

    Konopka, Jennifer L; Thompson, Joseph M; Whitmore, Alan C; Webb, Drue L; Johnston, Robert E


    The host innate immune response provides a critical first line of defense against invading pathogens, inducing an antiviral state to impede the spread of infection. While numerous studies have documented antiviral responses within actively infected tissues, few have described the earliest innate response induced systemically by infection. Here, utilizing Venezuelan equine encephalitis virus (VEE) replicon particles (VRP) to limit infection to the initially infected cells in vivo, a rapid activation of the antiviral response was demonstrated not only within the murine draining lymph node, where replication was confined, but also within distal tissues. In the liver and brain, expression of interferon-stimulated genes was detected by 1 to 3 h following VRP footpad inoculation, reaching peak expression of >100-fold over that in mock-infected animals. Moreover, mice receiving a VRP footpad inoculation 6, 12, or 24 h prior to an otherwise lethal VEE footpad challenge were completely protected from death, including a drastic reduction in challenge virus titers. VRP pretreatment also provided protection from intranasal VEE challenge and extended the average survival time following intracranial challenge. Signaling through the interferon receptor was necessary for antiviral gene induction and protection from VEE challenge. However, VRP pretreatment failed to protect mice from a heterologous, lethal challenge with vesicular stomatitis virus, yet conferred protection following challenge with influenza virus. Collectively, these results document a rapid modulation of the host innate response within hours of infection, capable of rapidly alerting the entire animal to pathogen invasion and leading to protection from viral disease.

  8. Erythrocyte heat shock protein responses to chronic (in vivo) and acute (in vitro) temperature challenge in diploid and triploid salmonids. (United States)

    Saranyan, Pillai V; Ross, Neil W; Benfey, Tillmann J


    This research investigated how ploidy level (diploid versus triploid) affects the heat shock protein (HSP) response in erythrocytes under different thermal stress regimes, both in vivo and in vitro, in Atlantic salmon (Salmo salar) and brook charr (Salvelinus fontinalis) in order to address the question of why triploids typically have reduced thermal tolerance. A preliminary study confirmed that identical volumes of diploid and triploid erythrocytes (which equates to a smaller number of larger cells for triploids compared to diploids) did not differ in total protein synthesis rates. After chronic (100d) acclimation of fish to 5, 15 and 25°C, triploid erythrocytes had lower HSP70, HSP90, heat shock factor 1 (HSF1) and ubiquitin (free and total) levels than diploids in both species. Furthermore, Atlantic salmon erythrocytes showed significantly higher protein breakdown (based on conjugated ubiquitin levels) in triploids than diploids after acute heat stress in vitro, but no significant difference was detected between ploidies after acute cold stress. These results indicate that: 1) triploid erythrocytes synthesize more total protein per cell than diploids as a result of increased cell size; 2) triploids have sufficient total HSP levels for survival under low stress conditions; and 3) the lower basal titres of HSPs in triploids may be a handicap when combating acute stress. Taken together, this suggests that triploids are limited in their ability to withstand thermal stress because of a reduced ability to maintain proteostasis under stressful conditions.

  9. Acute mammary and liver transcriptome responses after an intramammary Escherichia coli lipopolysaccharide challenge in postpartal dairy cows. (United States)

    Minuti, Andrea; Zhou, Zheng; Graugnard, Daniel E; Rodriguez-Zas, Sandra L; Palladino, Alejandro R; Cardoso, Felipe C; Trevisi, Erminio; Loor, Juan J


    The study investigated the effect of an intramammary lipopolysaccharide (LPS) challenge on the bovine mammary and liver transcriptome and its consequences on metabolic biomarkers and liver tissue composition. At 7 days of lactation, 7 cows served as controls (CTR) and 7 cows (LPS) received an intramammary Escherichia coli LPS challenge. The mammary and liver tissues for transcriptomic profiling were biopsied at 2.5 h from challenge. Liver composition was evaluated at 2.5 h and 7 days after challenge, and blood biomarkers were analyzed at 2, 3, 7 and 14 days from challenge. In mammary tissue, the LPS challenge resulted in 189 differentially expressed genes (DEG), with 20 down-regulated and 169 up-regulated. In liver tissue, there were 107 DEG in LPS compared with CTR with 42 down-regulated and 65 up-regulated. In mammary, bioinformatics analysis highlighted that LPS led to activation of NOD-like receptor signaling, Toll-like receptor signaling, RIG-I-like receptor signaling and apoptosis pathways. In liver, LPS resulted in an overall inhibition of fatty acid elongation in mitochondria and activation of the p53 signaling pathway. The LPS challenge induced changes in liver lipid composition, a systemic inflammation (rise of blood ceruloplasmin and bilirubin), and an increase in body fat mobilization. The data suggest that cells within the inflamed mammary gland respond by activating mechanisms of pathogen recognition. However, in the liver the response likely depends on mediators originating from the udder that affect liver functionality and specifically fatty acid metabolism (β-oxidation, ketogenesis, and lipoprotein synthesis).

  10. Physiological responses to digestion in low salinity in the crabs Carcinus maenas and Cancer irroratus. (United States)

    Penney, Chantelle M; Patton, Richard L; Whiteley, Nia M; Driedzic, William R; McGaw, Iain J


    Osmoregulation and digestion are energetically demanding, and crabs that move into low salinity environments to feed must be able to balance the demands of both processes. Achieving this balance may pose greater challenges for weak than for efficient osmoregulators. This study examined the rate of oxygen consumption (MO2) of Carcinus maenas (efficient osmoregulator) and Cancer irroratus (weak osmoregulator) as a function of feeding and hyposaline stress. The MO2 increased 2-fold in both species following feeding. The MO2 increased and remained elevated in fasted crabs during acute hyposaline exposure. When hyposaline stress occurred after feeding, C. maenas responded with an immediate summation of the MO2 associated with feeding and hyposaline stress, whereas C. irroratus reacted with a partial summation of responses in a salinity of 24‰, but were unable to sum responses in 16‰. C. irroratus exhibited longer gut transit times. This may be due to an inability to regulate osmotic water onload as efficiently as C. maenas. Mechanical digestion in crabs can account for a significant portion of SDA, and a short term interruption led to the delay in summation of metabolic demands. Although protein synthesis is reported to account for the majority of SDA, this did not appear to be the case here. Protein synthesis rates were higher in C. irroratus but neither feeding or salinity affected protein synthesis rates of either species which suggests that protein synthesis can continue in low salinity as long as substrates are available.

  11. Salinity modulates thermotolerance, energy metabolism and stress response in amphipods Gammarus lacustris

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    Kseniya P. Vereshchagina


    Full Text Available Temperature and salinity are important abiotic factors for aquatic invertebrates. We investigated the influence of different salinity regimes on thermotolerance, energy metabolism and cellular stress defense mechanisms in amphipods Gammarus lacustris Sars from two populations. We exposed amphipods to different thermal scenarios and determined their survival as well as activity of major antioxidant enzymes (peroxidase, catalase, glutathione S-transferase and parameters of energy metabolism (content of glucose, glycogen, ATP, ADP, AMP and lactate. Amphipods from a freshwater population were more sensitive to the thermal challenge, showing higher mortality during acute and gradual temperature change compared to their counterparts from a saline lake. A more thermotolerant population from a saline lake had high activity of antioxidant enzymes. The energy limitations of the freshwater population (indicated by low baseline glucose levels, downward shift of the critical temperature of aerobic metabolism and inability to maintain steady-state ATP levels during warming was observed, possibly reflecting a trade-off between the energy demands for osmoregulation under the hypo-osmotic condition of a freshwater environment and protection against temperature stress.

  12. Do Acartia tonsa (Dana) eggs regulate their volume and osmolality as salinity changes?

    DEFF Research Database (Denmark)

    Hansen, Benni Winding; Drillet, Guillaume; Pedersen, Morten Foldager;


    Subitaneous eggs from an euryhaline calanoid copepod Acartia tonsa were challenged by changes in salinity within the range from full strength salinity, down to zero and up to >70 psu. Egg volume changed immediately, increasing from 2.8 × 105 μm3 at full strength salinity (35 psu) to 3.8 × 105 μm3...... at 0 psu and back to its initial volume when gradually being returned to full strength salinity. Egg osmolality followed the molality of the surrounding water when challenged within a salinity range from 2 to 50 psu. Egg respiration was not affected when eggs kept at 35 psu was exposed to low salinity...... (2 psu). These results suggest that eggs are unable to regulate their volume or osmolality when challenged with changes in salinity. Gradual changes in salinity from 35 to 2 psu and back did not harm the eggs (embryos), since the hatching success remained unaffected by such changes in salinity...

  13. Salinity and water quality

    NARCIS (Netherlands)

    Sonneveld, C.; Voogt, W.


    The impact of salinity on greenhouse grown crops, especially when grown in substrate systems, differs from the impact of salinity on crops grown under field conditions. The most striking difference between greenhouse and field conditions is the overall much higher concentrations of nutrients in gree

  14. Correlation between the Movement Disorders Society Unified Parkinson's Disease rating scale (MDS-UPDRS) and the Unified Parkinson's Disease rating scale (UPDRS) during L-dopa acute challenge. (United States)

    Merello, Marcelo; Gerschcovich, Eliana Roldan; Ballesteros, Diego; Cerquetti, Daniel


    While Movement Disorders Society Unified Parkinson's Disease rating scale (MDS-UPDRS) validation has been exhaustive; performance evaluation to detect acute changes arising after administration of a single dose of L-dopa has yet to be explored. To determine the correlation between UPDRS and MDS-UPDRS during the acute challenge with Ldopa and the MDS-UPDRS equivalent to 30% cutoff score of UPDRS for defining responsiveness, 64 patients were assessed. Consecutive assessments were performed immediately before and after administration of a single dose of L-dopa/carbidopa 250/25 mg using the motor section of the UPDRS and the MDS-UPDRS. Good diagnostic accuracy, consistent with published findings of high correlation between scales was observed. Area under the curve (AUC) was 0.99 (CI = 0.97-1.00, P UPDRS and MDS-UPDRS and that the 30% of variation in UPDRS score used for predicting sustained long term L-dopa response was equivalent to 24% in MDS-UPDRS.

  15. Physiological benefits of being small in a changing world: responses of Coho salmon (Oncorhynchus kisutch to an acute thermal challenge and a simulated capture event.

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    Timothy D Clark

    Full Text Available Evidence is building to suggest that both chronic and acute warm temperature exposure, as well as other anthropogenic perturbations, may select for small adult fish within a species. To shed light on this phenomenon, we investigated physiological and anatomical attributes associated with size-specific responses to an acute thermal challenge and a fisheries capture simulation (exercise+air exposure in maturing male coho salmon (Oncorhynchus kisutch. Full-size females were included for a sex-specific comparison. A size-specific response in haematology to an acute thermal challenge (from 7 to 20 °C at 3 °C h(-1 was apparent only for plasma potassium, whereby full-size males exhibited a significant increase in comparison with smaller males ('jacks'. Full-size females exhibited an elevated blood stress response in comparison with full-size males. Metabolic recovery following exhaustive exercise at 7 °C was size-specific, with jacks regaining resting levels of metabolism at 9.3 ± 0.5 h post-exercise in comparison with 12.3 ± 0.4 h for full-size fish of both sexes. Excess post-exercise oxygen consumption scaled with body mass in male fish with an exponent of b = 1.20 ± 0.08. Jacks appeared to regain osmoregulatory homeostasis faster than full-size males, and they had higher ventilation rates at 1 h post-exercise. Peak metabolic rate during post-exercise recovery scaled with body mass with an exponent of b~1, suggesting that the slower metabolic recovery in large fish was not due to limitations in diffusive or convective oxygen transport, but that large fish simply accumulated a greater 'oxygen debt' that took longer to pay back at the size-independent peak metabolic rate of ~6 mg min(-1 kg(-1. Post-exercise recovery of plasma testosterone was faster in jacks compared with full-size males, suggesting less impairment of the maturation trajectory of smaller fish. Supporting previous studies, these findings suggest that environmental change and non

  16. Fish bone foreign body presenting with an acute fulminating retropharyngeal abscess in a resource-challenged center: a case report

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    Oyewole Ezekiel O


    Full Text Available Abstract Introduction A retropharyngeal abscess is a potentially life-threatening infection in the deep space of the neck, which can compromise the airway. Its management requires highly specialized care, including surgery and intensive care, to reduce mortality. This is the first case of a gas-forming abscess reported from this region, but not the first such report in the literature. Case presentation We present a case of a 16-month-old Yoruba baby girl with a gas-forming retropharyngeal abscess secondary to fish bone foreign body with laryngeal spasm that was managed in the recovery room. We highlight specific problems encountered in the management of this case in a resource-challenged center such as ours. Conclusion We describe an unusual presentation of a gas-forming organism causing a retropharyngeal abscess in a child. The patient's condition was treated despite the challenges of inadequate resources for its management. We recommend early recognition through adequate evaluation of any oropharyngeal injuries or infection and early referral to the specialist with prompt surgical intervention.

  17. Newly diagnosed glucose intolerance and prognosis after acute myocardial infarction: comparison of post-challenge versus fasting glucose concentrations (United States)

    Katayama, Minako; Takagi, Tsutomu; Yamamuro, Atsushi; Kaji, Shuichiro; Yoshikawa, Junichi; Furukawa, Yutaka


    Background Recent studies have demonstrated that newly diagnosed glucose intolerance is common among patients with acute myocardial infarction (AMI). The purpose of this study was to assess the long-term clinical cardiovascular outcomes in participants with AMI with abnormal fasting glucose compared with normal fasting glucose and an abnormal oral glucose tolerance test (OGTT) compared with a normal OGTT. Methods A prospective study was performed in 275 consecutive patients with AMI, 85 of whom had pre-diagnosed diabetes mellitus (DM). Those without DM were divided into two groups based on the 75 g OGTT at the time of discharge. Abnormal glucose tolerance (AGT) was defined as 2 h glucose ≥140 mg/dl; 78 patients had normal glucose tolerance (NGT) and 112 had AGT. The same patients were also reclassified into the normal fasting glucose group (NFG; n=168) or the impaired fasting glucose group (IFG; n=22). The association between the glucometabolic status and long-term major adverse cardiovascular event rates was evaluated. Results Kaplan–Meier survival curves showed that the AGT group had a worse prognosis than the NGT group and an equivalent prognosis to the DM group (p<0.0005). Cox proportional hazard model analysis showed that the HR of AGT to NGT for major adverse cardiovascular event rates was 2.65 (95% CI 1.37 to 5.15, p=0.004) while the HR of DM to NGT was 3.27 (1.68 to 6.38, p=0.0005). However, Cox HR of IFG to NFG for major adverse cardiovascular event rates was 1.83 (0.86 to 3.87), which was not significant. Conclusion In patients with AMI, an abnormal OGTT is a better risk factor for future adverse cardiovascular events than impaired fasting blood glucose. PMID:22581733

  18. A combination of l-arabinose and chromium lowers circulating glucose and insulin levels after an acute oral sucrose challenge

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    Perricone Nicholas V


    Full Text Available Abstract Background A growing body of research suggests that elevated circulating levels of glucose and insulin accelerate risk factors for a wide range of disorders. Low-risk interventions that could suppress glucose without raising insulin levels could offer significant long-term health benefits. Methods To address this issue, we conducted two sequential studies, the first with two phases. In the first phase of Study 1, baseline fasting blood glucose was measured in 20 subjects who consumed 70 grams of sucrose in water and subsequently completed capillary glucose measurements at 30, 45, 60 and 90 minutes (Control. On day-2 the same procedure was followed, but with subjects simultaneously consuming a novel formula containing l-arabinose and a trivalent patented food source of chromium (LA-Cr (Treatment. The presence or absence of the LA-Cr was blinded to the subjects and testing technician. Comparisons of changes from baseline were made between Control and Treatment periods. In the second phase of Study 1, 10 subjects selected from the original 20 competed baseline measures of body composition (DXA, a 43-blood chemistry panel and a Quality of Life Inventory. These subjects subsequently took LA-Cr daily for 4 weeks completing daily tracking forms and repeating the baseline capillary tests at the end of each of the four weeks. In Study 2, the same procedures used in the first phase were repeated for 50 subjects, but with added circulating insulin measurements at 30 and 60 minutes from baseline. Results In both studies, as compared to Control, the Treatment group had significantly lower glucose responses for all four testing times (AUC = P P = Conclusions As compared to a placebo control, consumption of a LA-Cr formula after a 70-gram sucrose challenge was effective in safely lowering both circulating glucose and insulin levels. Trial Registration Clinical, NCT0110743


    Institute of Scientific and Technical Information of China (English)

    王悦如; 李二超; 陈立侨; 王晓丹; 张凤英; 高露姣; 龙丽娜


    12h at salinity 30%o, and then gradually increased after 24h. All these results indicated that E. sinensis could produce physiological and biochemical adaptation to maintain a stable osmotic pressure during acute salinity stress. Carbohydrate and protein play important roles in the osmoregulation of crustaceans. E. sinensis could use carbohydrate first to provide energy under acute salinity stress. The higher the salinity, the faster the haemolymph glucose was consumed, and it also recovered more quickly. This observation suggested that carbohydrate could be a direct source in osmoregulation. The crabs may use protein to maintain the balance of osmotic pressure under high salinity by metabolizing the protein into free amino acids. Beside providing free amino acids, hemocyanin also can carry oxygen to meet the needs for physiological activities. Therefore, more attention should be paid to carbohydrate and protein supplied under salinity stress. The ratio of free amino acids maintaining the balance of osmotic pressure and supplying energy by oxidation and the utilization of lipid in osmoregulation require further study. Since the lipid contents in haemolymph and hepatopancreas were not determined in this study, the role of body lipid in E. sinensis was not discussed here and should be further examined.%实验以淡水(0.3‰)处理组为对照,研究了急性高渗胁迫(盐度16‰和30‰)对中华绒螯蟹(Eriocheir sinensis)雄蟹血淋巴和肝胰腺中可溶性蛋白质、血蓝蛋白、血糖及肝糖原含量的影响.结果显示,与对照组相比,进入16‰及30‰盐度后,蟹的血淋巴中可溶性蛋白质含量从6-48h显著降低(P0.05),而30‰盐度组其血糖含量早在6-12h时就有显著的下降(P<0.05),到24h则开始逐渐升高.研究表明,在急性盐度胁迫下,糖类和蛋白质对中华绒螯蟹渗透压调节起重要的作用,其优先利用糖类的分解获得所需的能量,其中盐度越高,机体内葡萄糖的消耗越快,

  20. Tolerância de juvenis do pampo Trachinotus marginatus (Teleostei, Carangidae ao choque agudo de salinidade em laboratório Acute salinity tolerance of juvenile pompano Trachinotus marginatus (Teleostei, Carangidae under laboratory conditions

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    Luís André Sampaio


    Full Text Available O pampo Trachinotus marginatus é uma espécie com potencial para piscicultura, mas a sua utilização pode ser limitada pelas variações de salinidade comuns em estuários ou em ambientes super-salinos. Este trabalho foi realizado com o objetivo de determinar a tolerância à salinidade de juvenis de T. marginatus em laboratório. Foram testadas 12 salinidades em duplicata (0, 6, 8, 10, 15, 25, 45, 55, 58, 61, 65 e 75‰ e um tratamento controle (35‰. Dez peixes (comprimento total: 20,7±2,3mm e peso úmido: 427±113mg foram colocados em tanques plásticos de 3L. A temperatura da água foi mantida em 24ºC com um banho termostatisado, aeração constante e, a cada 24 horas, os meios experimentais foram completamente renovados. Após 96 horas de exposição, as salinidades letais médias inferior e superior, com os respectivos intervalos de confiança (IC 95%, foram estimadas em 6,99‰ (IC 95% = 6,86-7,13‰ e 58,50‰ (IC 95% = 56,81-60,24‰, respectivamente. Estes resultados permitem caracterizar esta espécie como eurialina. O estudo da influência da salinidade sobre T. marginatus deve ser aprofundado, buscando avaliar principalmente os efeitos sobre o crescimento, de modo que seja possível determinar o potencial do seu cultivo em ambientes com diferentes salinidades.The pompano Trachinotus marginatus shows good potential for aquaculture, but the success of its culture might be limited by the salinity fluctuations common in estuaries or in hyper-saline environments. The objective of this work was to establish the salinity tolerance of juvenile T. marginatus under laboratory conditions. Twelve salinities (0, 6, 8, 10, 15, 25, 45, 55, 58, 61, 65, and 75‰ plus a control (35‰ were tested in duplicate. Groups of ten fish (total length: 20.7±2,3mm and wet weight: 427±113mg were placed in plastic tanks with 3L of water. A water bath was set to control the temperature at 24ºC, water was continuously aerated, and completely exchanged

  1. Salinity influences the biochemical response of Crassostrea angulata to Arsenic. (United States)

    Moreira, Anthony; Figueira, Etelvina; Soares, Amadeu M V M; Freitas, Rosa


    The increasing rate of occurrence and persistence of climatic events causing salinity shifts, in combination with contamination, may further challenge organisms response to environmental stress. Hence, we studied the effects of different salinity levels (10, 20, 30 and 40) on the response of the oyster Crassostrea angulata to Arsenic (As) exposure (4 mg L(-1)). Total As, Na(+) and K(+) concentrations in oyster tissues were determined. Biochemical analysis were performed to assess osmotic regulation (CA), metabolism (ETS), enzymatic (SOD, CAT and GSTs) and non-enzymatic (GSH/GSSG and LPO) markers of oxidative stress. Results obtained showed significantly higher metabolic activities in oysters maintained in low salinity (10) exposure, coupled with higher As accumulation, as well as higher SOD and CAT activities, compared to higher salinities (30 and 40). GSTs activity and LPO levels were higher in oysters exposed to As at salinities 20, 30 and 40, compared to the same conditions without As. From our findings we concluded that the response of C. angulata to As is influenced by salinity. At the lowest salinity (10) oysters accumulated higher As concentrations, here attributed to higher metabolic rate involved in physiological osmoregulation, also stimulating antioxidant related enzymes activity (SOD and CAT) and thus preventing increased LPO (higher ETS activity also observed without As). On the contrary, at salinities 30 and 40 with As, antioxidant SOD and CAT were inhibited, enabling for LPO generation. Given our results, the effects of As on the oysters antioxidant capacity appears to be more deleterious under higher salinities (20, 30 and 40), comparing to salinity 10. The differentiated responses demonstrated in the present study in C. angulata oysters exposed to As under different salinities, bring new insights on the mechanisms of environmental adaptability of this species, namely to salinity shifts, and the interactions between such alterations and As

  2. Breast Implants: Saline vs. Silicone (United States)

    ... differ in material and consistency, however. Saline breast implants Saline implants are filled with sterile salt water. ... of any age for breast reconstruction. Silicone breast implants Silicone implants are pre-filled with silicone gel — ...

  3. Salinity controls on Na incorporation in Red Sea planktonic foraminifera (United States)

    Mezger, E. M.; Nooijer, L. J.; Boer, W.; Brummer, G. J. A.; Reichart, G. J.


    Whereas several well-established proxies are available for reconstructing past temperatures, salinity remains challenging to assess. Reconstructions based on the combination of (in)organic temperature proxies and foraminiferal stable oxygen isotopes result in relatively large uncertainties, which may be reduced by application of a direct salinity proxy. Cultured benthic and planktonic foraminifera showed that Na incorporation in foraminiferal shell calcite provides a potential independent proxy for salinity. Here we present the first field calibration of such a potential proxy. Living planktonic foraminiferal specimens from the Red Sea surface waters were collected and analyzed for their Na/Ca content using laser ablation quadrupole inductively coupled plasma mass spectrometry. Using the Red Sea as a natural laboratory, the calibration covers a broad range of salinities over a steep gradient within the same water mass. For both Globigerinoides ruber and Globigerinoides sacculifer calcite Na/Ca increases with salinity, albeit with a relatively large intraspecimen and interspecimen variability. The field-based calibration is similar for both species from a salinity of 36.8 up to 39.6, while values for G. sacculifer deviate from this trend in the northernmost transect. It is hypothesized that the foraminifera in the northernmost part of the Red Sea are (partly) expatriated and hence should be excluded from the Na/Ca-salinity calibration. Incorporation of Na in foraminiferal calcite therefore provides a potential proxy for salinity, although species-specific calibrations are still required and more research on the effect of temperature is needed.

  4. Effects of salinity on leaf breakdown: Dryland salinity versus salinity from a coalmine. (United States)

    Sauer, Felix G; Bundschuh, Mirco; Zubrod, Jochen P; Schäfer, Ralf B; Thompson, Kristie; Kefford, Ben J


    Salinization of freshwater ecosystems as a result of human activities represents a global threat for ecosystems' integrity. Whether different sources of salinity with their differing ionic compositions lead to variable effects in ecosystem functioning is unknown. Therefore, the present study assessed the impact of dryland- (50μS/cm to 11,000μS/cm) and coalmine-induced (100μS/cm to 2400μS/cm) salinization on the leaf litter breakdown, with focus on microorganisms as main decomposer, in two catchments in New South Wales, Australia. The breakdown of Eucalyptus camaldulensis leaves decreased with increasing salinity by up to a factor of three. Coalmine salinity, which is characterised by a higher share of bicarbonates, had a slightly but consistently higher breakdown rate at a given salinity relative to dryland salinity, which is characterised by ionic proportions similar to sea water. Complementary laboratory experiments supported the stimulatory impact of sodium bicarbonates on leaf breakdown when compared to sodium chloride or artificial sea salt. Furthermore, microbial inoculum from a high salinity site (11,000μS/cm) yielded lower leaf breakdown at lower salinity relative to inoculum from a low salinity site (50μS/cm). Conversely, inoculum from the high salinity site was less sensitive towards increasing salinity levels relative to inoculum from the low salinity site. The effects of the different inoculum were the same regardless of salt source (sodium bicarbonate, sodium chloride and artificial sea salt). Finally, the microorganism-mediated leaf litter breakdown was most efficient at intermediate salinity levels (≈500μS/cm). The present study thus points to severe implications of increasing salinity intensities on the ecosystem function of leaf litter breakdown, while the underlying processes need further scrutiny.

  5. Electronic Nose Breathprints Are Independent of Acute Changes in Airway Caliber in Asthma

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    Jan van der Maten


    Full Text Available Molecular profiling of exhaled volatile organic compounds (VOC by electronic nose technology provides breathprints that discriminate between patients with different inflammatory airway diseases, such as asthma and COPD. However, it is unknown whether this is determined by differences in airway caliber. We hypothesized that breathprints obtained by electronic nose are independent of acute changes in airway caliber in asthma. Ten patients with stable asthma underwent methacholine provocation (Visit 1 and sham challenge with isotonic saline (Visit 2. At Visit 1, exhaled air was repetitively collected pre-challenge, after reaching the provocative concentration (PC20 causing 20% fall in forced expiratory volume in 1 second (FEV1 and after subsequent salbutamol inhalation. At Visit 2, breath was collected pre-challenge, post-saline and post-salbutamol. At each occasion, an expiratory vital capacity was collected after 5 min of tidal breathing through an inspiratory VOC-filter in a Tedlar bag and sampled by electronic nose (Cyranose 320. Breathprints were analyzed with principal component analysis and individual factors were compared with mixed model analysis followed by pairwise comparisons. Inhalation of methacholine led to a 30.8 ± 3.3% fall in FEV1 and was followed by a significant change in breathprint (p = 0.04. Saline inhalation did not induce a significant change in FEV1, but altered the breathprint (p = 0.01. However, the breathprint obtained after the methacholine provocation was not significantly different from that after saline challenge (p = 0.27. The molecular profile of exhaled air in patients with asthma is altered by nebulized aerosols, but is not affected by acute changes in airway caliber. Our data demonstrate that breathprints by electronic nose are not confounded by the level of airway obstruction.

  6. Salinity driven oceanographic upwelling (United States)

    Johnson, D.H.


    The salinity driven oceanographic upwelling is maintained in a mariculture device that includes a long main duct in the general shape of a cylinder having perforated cover plates at each end. The mariculture device is suspended vertically in the ocean such that one end of the main duct is in surface water and the other end in relatively deep water that is cold, nutrient rich and relatively fresh in comparison to the surface water which is relatively warm, relatively nutrient deficient and relatively saline. A plurality of elongated flow segregating tubes are disposed in the main duct and extend from the upper cover plate beyond the lower cover plate into a lower manifold plate. The lower manifold plate is spaced from the lower cover plate to define a deep water fluid flow path to the interior space of the main duct. Spacer tubes extend from the upper cover plate and communicate with the interior space of the main duct. The spacer tubes are received in an upper manifold plate spaced from the upper cover plate to define a surface water fluid flow path into the flow segregating tubes. A surface water-deep water counterflow is thus established with deep water flowing upwardly through the main duct interior for discharge beyond the upper manifold plate while surface water flows downwardly through the flow segregating tubes for discharge below the lower manifold plate. During such counterflow heat is transferred from the downflowing warm water to the upflowing cold water. The flow is maintained by the difference in density between the deep water and the surface water due to their differences in salinity. The upwelling of nutrient rich deep water is used for marifarming by fertilizing the nutrient deficient surface water. 1 fig.

  7. Epinephrine Improves the Efficacy of Nebulized Hypertonic Saline in Moderate Bronchiolitis: A Randomised Clinical Trial.

    Directory of Open Access Journals (Sweden)

    J Carlos Flores-González

    Full Text Available There is no evidence that the epinephrine-3% hypertonic saline combination is more effective than 3% hypertonic saline alone for treating infants hospitalized with acute bronchiolitis. We evaluated the efficacy of nebulized epinephrine in 3% hypertonic saline.We performed a randomized, double-blind, placebo-controlled clinical trial in 208 infants hospitalized with acute moderate bronchiolitis. Infants were randomly assigned to receive nebulized 3% hypertonic saline with either 3 mL of epinephrine or 3 mL of placebo, administered every four hours. The primary outcome measure was the length of hospital stay.A total of 185 infants were analyzed: 94 in the epinephrine plus 3% hypertonic saline group and 91 in the placebo plus 3% hypertonic saline group. Baseline demographic and clinical characteristics were similar in both groups. Length of hospital stay was significantly reduced in the epinephrine group as compared with the placebo group (3.94 ±1.88 days vs. 4.82 ±2.30 days, P = 0.011. Disease severity also decreased significantly earlier in the epinephrine group (P = 0.029 and P = 0.036 on days 3 and 5, respectively.In our setting, nebulized epinephrine in 3% hypertonic saline significantly shortens hospital stay in hospitalized infants with acute moderate bronchiolitis compared to 3% hypertonic saline alone, and improves the clinical scores of severity from the third day of treatment, but not before.EudraCT 2009-016042-57.

  8. Constitutive, but Not Challenge-Induced, Interleukin-10 Production Is Robust in Acute Pre-Pubescent Protein and Energy Deficits: New Support for the Tolerance Hypothesis of Malnutrition-Associated Immune Depression Based on Cytokine Production in vivo

    Directory of Open Access Journals (Sweden)

    Bill Woodward


    Full Text Available The tolerance model of acute (i.e., wasting pre-pubescent protein and energy deficits proposes that the immune depression characteristic of these pathologies reflects an intact anti-inflammatory form of immune competence that reduces the risk of autoimmune reactions to catabolically released self antigens. A cornerstone of this proposition is the finding that constitutive (first-tier interleukin(IL-10 production is sustained even into the advanced stages of acute malnutrition. The IL-10 response to inflammatory challenge constitutes a second tier of anti-inflammatory regulation and was the focus of this investigation. Weanling mice consumed a complete diet ad libitum, a low-protein diet ad libitum (mimicking incipient kwashiorkor, or the complete diet in restricted daily quantities (mimicking marasmus, and their second-tier IL-10 production was determined both in vitro and in vivo using lipopolysaccharide (LPS and anti-CD3 as stimulants of innate and adaptive defences, respectively. Both early (3 days and advanced (14 days stages of wasting pathology were examined and three main outcomes emerged. First, classic in vitro systems are unreliable for discerning cytokine production in vivo. Secondly, in diverse forms of acute malnutrition declining challenge-induced IL-10 production may provide an early sign that anti-inflammatory control over immune competence is failing. Thirdly, and most fundamentally, the investigation provides new support for the tolerance model of malnutrition-associated inflammatory immune depression.

  9. Aquarius Instrument and Salinity Retrieval (United States)

    Le Vine, D. M.


    Aquarius has been designed to map the surface salinity field of the global ocean from space a parameter important for understanding ocean circulation and its relationship to climate and the global water cycle. Salinity is measured remotely from space by measuring the thermal emission from the ocean surface. This is done at the low frequency end of the microwave spectrum (e.g. 1.4 GHz) where the emission is sufficiently sensitive to changes in salinity to be detected with sophisticated radiometers. The goal is to monitor the seasonal and interannual variation of the large scale features of the surface salinity field in the open ocean by providing maps on a monthly basis with a spatial resolution of 150 km and an accuracy of 0.2 psu. These are challenging requirements that have led to some unique features of the instrument. These include: a) The addition of a co-located scatterometer to help provide a correction for roughness; b) The addition of a polarimetric channel (third Stokes parameter) to the radiometer to help correct for Faraday rotation; c) Asun-synchronous orbit with a 6 pm ascending equatorial crossing to minimize Faraday rotation and with the antennas looking away from the sun toward the nighttime side to minimize contamination by radiation from the sun; and d) An antenna designed to limit side lobes in the direction of rays from the sun. In addition, achieving the accuracy goal of 0.2 psu requires averaging over one month and to do this requires a highly stable radiometer. Aquarius has three separate radiometers that image in pushbroom fashion with the three antenna beams looking across track. The antenna is a 2.5-m diameter, offset parabolic reflector with three feed horns and the three beams are arranged to image with the boresight aligned to look across track, roughly perpendicular to the spacecraft heading and pointing away from the Sun. The three beams point at angles of theta = 25.8 deg., 33.8 deg. and 40.3 deg. with respect to the spacecraft

  10. Plant growth under high salinity

    NARCIS (Netherlands)

    Blom, M.; Brandenburg, W.A.


    Plants most suitable for growing under high saline or even seawater conditions are the ones naturally living under high saline circumstances. A series of tolerant or moderate salt tolerant plants are experimentally tested and described in literature. For many species of this group a threshold value

  11. A Challenge for Diagnosing Acute Liver Injury with Concomitant/Sequential Exposure to Multiple Drugs: Can Causality Assessment Scales Be Utilized to Identify the Offending Drug?

    Directory of Open Access Journals (Sweden)

    Roxanne Lim


    Full Text Available Drug-induced hepatotoxicity most commonly manifests as an acute hepatitis syndrome and remains the leading cause of drug-induced death/mortality and the primary reason for withdrawal of drugs from the pharmaceutical market. We report a case of acute liver injury in a 12-year-old Hispanic boy, who received a series of five antibiotics (amoxicillin, ceftriaxone, vancomycin, ampicillin/sulbactam, and clindamycin for cervical lymphadenitis/retropharyngeal cellulitis. Histopathology of the liver biopsy specimen revealed acute cholestatic hepatitis. All known causes of acute liver injury were appropriately excluded and (only drug-induced liver injury was left as a cause of his cholestasis. Liver-specific causality assessment scales such as Council for the International Organization of Medical Sciences/Roussel Uclaf Causality Assessment Method scoring system (CIOMS/RUCAM, Maria and Victorino scale, and Digestive Disease Week-Japan were applied to seek the most likely offending drug. Although clindamycin is the most likely cause by clinical diagnosis, none of causality assessment scales aid in the diagnosis.

  12. Toxicity of trace element and salinity mixtures to striped bass (Morone saxatilis) and Daphnia magna (United States)

    Dwyer, F.J.; Burch, S.A.; Ingersoll, C.G.; Hunn, J.B.


    Acute toxicity tests with reconstituted water were conducted to investigate the relationship between water hardness, salinity, and a mixture of trace elements found in irrigation drain waters entering Stillwater Wildlife Management Area (SWMA), near Fallon, Nevada. The SWMA has been the site of many fish kills in recent years, and previous toxicity studies indicated that one drain water, Pintail Bay, was acutely toxic to organisms acclimated or cultured in fresh water or salt water. This toxicity could reflect both the ionic composition of this saline water and the presence of trace elements. The lowest water salinity tested with Daphnia magna was near the upper salinity tolerance of these organisms; therefore, we were unable to differentiate between the toxic effects of ion composition and those of trace elements. In toxicity tests conducted with striped bass (Morone saxatilis), we found that the extent to which salinity was lethal to striped bass depended on the ion composition of that salinity. Survival of striped bass increased as hardness increased. In addition, a trace element mixture was toxic to striped bass, even though the concentrations of individual elements were below expected acutely lethal concentrations. Although salinity is an important water quality characteristic, the ionic composition of the water must be considered when one assesses the hazard of irrigation drain waters to aquatic organisms.

  13. Transcriptomic response to low salinity stress in gills of the Pacific white shrimp, Litopenaeus vannamei. (United States)

    Hu, Dongxu; Pan, Luqing; Zhao, Qun; Ren, Qin


    The Pacific white shrimp, Litopenaeus vannamei (L. vannamei), is one of the most farmed species. Salinity is an important environmental factor that affects its growth and distribution. However, the molecular mechanism of the shrimp in response to salinity stress remains largely unclear. High-throughput sequencing is a helpful tool to analyze the molecular response to salinity challenge in shrimp. In the present study, the transcriptomic responses of the gills in L. vannamei under low salinity stress were detected by Illumina's digital gene expression system. A total of 10,725,789 and 10,827,411 reads were generated from the non-changed and low salinity changed groups, respectively. 64,590 Unigenes with an average length of 764 bp were generated. Compared with the control, 585 genes were differentially expressed under low salinity. GO functional analysis and KEGG pathway analysis indicated some vital genes in response to the challenge. Ten genes related to osmoregulation and ambient salinity adaption were selected to validate the DGE results by RT-qPCR. This work provides valuable information to study the mechanism of salinity adaption in L. vannamei. Genes and pathways from the results will be beneficial to reveal the molecular basis of osmoregulation. It also gives an insight into the response to the salinity challenge in L. vannamei.

  14. Salinity Gradients for Sustainable Energy: Primer, Progress, and Prospects. (United States)

    Yip, Ngai Yin; Brogioli, Doriano; Hamelers, Hubertus V M; Nijmeijer, Kitty


    Combining two solutions of different composition releases the Gibbs free energy of mixing. By using engineered processes to control the mixing, chemical energy stored in salinity gradients can be harnessed for useful work. In this critical review, we present an overview of the current progress in salinity gradient power generation, discuss the prospects and challenges of the foremost technologies - pressure retarded osmosis (PRO), reverse electrodialysis (RED), and capacitive mixing (CapMix) and provide perspectives on the outlook of salinity gradient power generation. Momentous strides have been made in technical development of salinity gradient technologies and field demonstrations with natural and anthropogenic salinity gradients (for example, seawater-river water and desalination brine-wastewater, respectively), but fouling persists to be a pivotal operational challenge that can significantly ebb away cost-competitiveness. Natural hypersaline sources (e.g., hypersaline lakes and salt domes) can achieve greater concentration difference and, thus, offer opportunities to overcome some of the limitations inherent to seawater-river water. Technological advances needed to fully exploit the larger salinity gradients are identified. While seawater desalination brine is a seemingly attractive high salinity anthropogenic stream that is otherwise wasted, actual feasibility hinges on the appropriate pairing with a suitable low salinity stream. Engineered solutions are foulant-free and can be thermally regenerative for application in low-temperature heat utilization. Alternatively, PRO, RED, and CapMix can be coupled with their analog separation process (reverse osmosis, electrodialysis, and capacitive deionization, respectively) in salinity gradient flow batteries for energy storage in chemical potential of the engineered solutions. Rigorous techno-economic assessments can more clearly identify the prospects of low-grade heat conversion and large-scale energy storage

  15. Salinity effects on Atlantic sturgeon growth and osmoregulation (United States)

    The Atlantic sturgeon (Acipenser oxyrinchus oxyrinchus Mitchill, 1815) is an anadromous sturgeon species, yet little is known with regard to its osmoregulatory ability and habitat use at early life stages. In order to examine whether salinity poses a physiological challenge to juvenile Atlantic stur...

  16. Effects of Slow-stroke Back Massage on Chemotherapy-induced Nausea and Vomiting in the Pediatrics with Acute Leukemia: a Challenge of Controlling Symptoms

    Directory of Open Access Journals (Sweden)

    Mojtaba Miladinia


    Full Text Available Introduction Nausea and vomiting are the most common side effects of chemotherapy in the pediatrics with cancer which affect their quality of life. Use of some methods of complementary medicine in leukemia patients is problematic. Because, leukemia patients are at risk of infection and bleeding, therefore the use of acupressure, acupuncture, and deep massage can be risky in these patients. Slow- stroke back massage is applied on the surface of body, so does not have complications. No study has addressed the effect of massage therapy on chemotherapy-induced nausea and vomiting in pediatrics with acute leukemia in the world.  Material and methods This study was a two-group randomized controlled trial (RCT, double blind and repeated measures design. In this RCT, 45 school age children with acute leukemia were placed in the massage and control groups. Before start of the study, at the day of chemotherapy administration (day 1th, only nausea and vomiting were measured. Then during 6 days next (day 2 through 7, the intervention group received 5-minutes Super Smash Bros. Melee (SSBM, immediately before start of each session of chemotherapy. Nausea was measured during chemotherapy, 0.5 h and 3 h after each session of chemotherapy in the two groups. Also vomiting was recorded during 24 h after each session of chemotherapy. Repeated measures ANOVA, Chi-square, and t-test were used for analysis. Results Most of pediatrics were male (58.13%, and suffered from Acute myeloid leukemia (AML (81.7%. The repeated measure analysis showed that in the intervention group, the SSBM reduced progressive mean of nausea severity and frequency of vomit over time. While, this side effects have slightly increased over time in the control group. Conclusion The results of this study are suggesting that SSBM, as a non-pharmacologic, easy and safe method, is effective in controlling Chemotherapy-induced nausea and vomiting (CINV in the pediatrics with acute leukemia.

  17. NOAA Average Annual Salinity (3-Zone) (United States)

    California Department of Resources — The 3-Zone Average Annual Salinity Digital Geography is a digital spatial framework developed using geographic information system (GIS) technology. These salinity...

  18. Salinity and suspended matter variations in the Tay estuary (United States)

    McManus, John


    The concept of salinity-induced density layering in estuaries was first demonstrated from the upper reaches of the Tay. In this study the nature of the layering and its variation through the tidal cycle is demonstrated from time series of observations taken at many locations within this estuary. Thorough mixing of the waters on the rising tide, as defined by depth profiles of salinity, is commonly replaced by salinity layering during the high water slack period. This condition continues into the falling tide. Frequently the mixed waters are abruptly replaced by stratified waters within the half-hourly sampling interval. This is attributed to the activity of longitudinal fronts, manifest as surficial foam bands, along which water masses shear past each other on both the flood and ebb tides. Offsetting of transverse salinity coutours along the fronts is introduced to explain apparent complexities in surface water salinity distributions measured at high water slack. Suspended particulate matter concentrations increase towards the limit of the saline water intrusion before decreasing headwards into the freshwater zone of the estuary. The suspensions in the water column may also be displaced by the lateral offsetting of the waters along the fronts. The recognition of the presence of fronts, and a knowledge of their impact on the estuarine waters may provide an alternative means of understanding the flow characteristics of these challenging water bodies. The techniques of spatial and temporal averaging normally widely used today may not be the most realistic approach to analysis of the flows.

  19. Therapeutic effects of compound hypertonic saline on rats with sepsis

    Directory of Open Access Journals (Sweden)

    Fang Dong


    Full Text Available Sepsis is one of the major causes of death and is the biggest obstacle preventing improvement of the success rate in curing critical illnesses. Currently, isotonic solutions are used in fluid resuscitation technique. Several studies have shown that hypertonic saline applied in hemorrhagic shock can rapidly increase the plasma osmotic pressure, facilitate the rapid return of interstitial fluid into the blood vessels, and restore the effective circulating blood volume. Here, we established a rat model of sepsis by using the cecal ligation and puncture approach. We found that intravenous injection of hypertonic saline dextran (7.5% NaCl/6% dextran after cecal ligation and puncture can improve circulatory failure at the onset of sepsis. We found that the levels of tumor necrosis factor-α, interleukin-1β, interleukin-6 and intracellular adhesion molecule 1 levels in the lung tissue of cecal ligation and puncture rats treated with hypertonic saline dextran were significantly lower than the corresponding levels in the control group. We inferred that hypertonic saline dextran has a positive immunoregulatory effect and inhibits the overexpression of the inflammatory response in the treatment of sepsis. The percentage of neutrophils, lung myeloperoxidase activity, wet to dry weight ratio of lung tissues, histopathological changes in lung tissues, and indicators of arterial blood gas analysis was significantly better in the hypertonic saline dextran-treated group than in the other groups in this study. Hypertonic saline dextran-treated rats had significantly improved survival rates at 9 and 18 h compared to the control group. Our results suggest that hypertonic saline dextran plays a protective role in acute lung injury caused after cecal ligation and puncture. In conclusion, hypertonic/hyperoncotic solutions have beneficial therapeutic effects in the treatment of an animal model of sepsis.

  20. NOAA NOS SOS, EXPERIMENTAL - Salinity (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have salinity data. *These services are for testing and evaluation use...

  1. World Ocean Atlas 2005, Salinity (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — World Ocean Atlas 2005 (WOA05) is a set of objectively analyzed (1° grid) climatological fields of in situ temperature, salinity, dissolved oxygen, Apparent Oxygen...

  2. World Ocean Atlas 2005, Salinity (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — World Ocean Atlas 2005 (WOA05) is a set of objectively analyzed (1° grid) climatological fields of in situ temperature, salinity, dissolved oxygen, Apparent Oxygen...

  3. Stochastic Modeling of Soil Salinity

    CERN Document Server

    Suweis, S; Van der Zee, S E A T M; Daly, E; Maritan, A; Porporato, A; 10.1029/2010GL042495


    A minimalist stochastic model of primary soil salinity is proposed, in which the rate of soil salinization is determined by the balance between dry and wet salt deposition and the intermittent leaching events caused by rainfall events. The long term probability density functions of salt mass and concentration are found by reducing the coupled soil moisture and salt mass balance equation to a single stochastic differential equation driven by multiplicative Poisson noise. The novel analytical solutions provide insight on the interplay of the main soil, plant and climate parameters responsible for long-term soil salinization. In particular, they show the existence of two distinct regimes, one where the mean salt mass remains nearly constant (or decreases) with increasing rainfall frequency, and another where mean salt content increases markedly with increasing rainfall frequency. As a result, relatively small reductions of rainfall in drier climates may entail dramatic shifts in long-term soil salinization trend...

  4. Larval tolerance to salinity in three species of Australian anuran: an indication of saline specialisation in Litoria aurea.

    Directory of Open Access Journals (Sweden)

    Brian D Kearney

    Full Text Available Recent anthropogenic influences on freshwater habitats are forcing anuran populations to rapidly adapt to high magnitude changes in environmental conditions or face local extinction. We examined the effects of ecologically relevant elevated salinity levels on larval growth, metamorphosis and survival of three species of Australian anuran; the spotted marsh frog (Limnodynastes tasmaniensis, the painted burrowing frog (Neobatrachus sudelli and the green and golden bell frog (Litoria aurea, in order to better understand the responses of these animals to environmental change. Elevated salinity (16% seawater negatively impacted on the survival of L. tasmaniensis (35% survival and N sudelli (0% survival, while reduced salinity had a negative impact on L. aurea. (16% seawater: 85% survival; 0.4% seawater: 35% survival. L. aurea tadpoles survived in salinities much higher than previously reported for this species, indicating the potential for inter-populations differences in salinity tolerance. In L. tasmaniensis and L. aurea, development to metamorphosis was fastest in low and high salinity treatments suggesting it is advantageous for tadpoles to invest energy in development in both highly favourable and developmentally challenging environments. We propose that this response might either maximise potential lifetime fecundity when tadpoles experience favourable environments, or, facilitate a more rapid escape from pond environments where there is a reduced probability of survival.

  5. Challenges of implementing national guidelines for the control and prevention of methicillin-resistant Staphylococcus aureus colonization or infection in acute care hospitals in the Republic of Ireland.

    LENUS (Irish Health Repository)

    Fitzpatrick, Fidelma


    Of the 49 acute care hospitals in Ireland that responded to the survey questionnaire drafted by the Infection Control Subcommittee of the Health Protection Surveillance Centre\\'s Strategy for the Control of Antimicrobial Resistance in Ireland, 43 reported barriers to the full implementation of national guidelines for the control and prevention of methicillin-resistant Staphylococcus aureus infection; these barriers included poor infrastructure (42 hospitals), inadequate laboratory resources (40 hospitals), inadequate staffing (39 hospitals), and inadequate numbers of isolation rooms and beds (40 hospitals). Four of the hospitals did not have an educational program on hand hygiene, and only 17 had an antibiotic stewardship program.

  6. Acute Pancreatitis: Surgery, Pathophysiology and Probiotic Prophylaxis

    NARCIS (Netherlands)

    Minnen, L.P. van


    Acute pancreatitis is a challenging disease with a clinical course that is often difficult to predict. In severe acute pancreatitis, mortality increases significantly if intestinal bacteria translocate from the intestine and infect pancreatic necrosis. Surgical and prophylactic treatment strategies

  7. Clinical experiences of normal saline pressed injection via lumbar puncture in the treatment of apnea due to acute tonsillar hernia%采用腰穿加压注液方法抢救急性枕骨大孔疝致呼吸停止的临床疗效

    Institute of Scientific and Technical Information of China (English)

    孟庆虎; 曲春城; 魏麟; 李新钢; 李刚; 费昶; 孙金龙; 王成伟; 张庆林


    Objective To summarize the clinical experiences of normal saline pressed injection via lumbar puncture in the treatment of acute tonsillar hernia induced apnea.This procedure was routinely carried out after external ventricular drainage and/or lesion removal via open craniotomy.Methods During the period of 1969 to 2005,a total of 43 patients failed to regain respiratory after external ventricular drainage using rapid small hole cranio-puncture apparatus or lesion removal via open craniotomy.They underwent lumbar puncture and normal saline was pressed injected via a lumbar puncture needle.The patient data were retrospectively analyzed.Results Eleven of 43 patients had spontaneous respiration and fully recovered (25.6% ),16 patients regained respiration but died eventually (37.2% ) and 16 patients failed to regain respiration ( 37.2% ).The effective rate was 62.8%.Conclusion For the patients failing to regain respiration after external ventricular drainage or supratentorial lesion removal via open craniotomy,the conservative treatment should not be the first choice.The pressed injection of normal saline via lumbar puncture may rescue some patients.%目的 总结应用快速细孔钻颅脑室体外引流术或开颅病变清除减压术后,进行腰穿加压注液抢救枕骨大孔疝所致呼吸骤停患者的经验.方法 自1969至2005年山东大学齐鲁医院及山东大学第二医院共同采用腰穿加压注液方法,救治43例急性枕骨大孔疝患者,43例均为进行快速细孔钻颅脑室外引流或幕上病变开颅清除减压术后,自主呼吸仍不恢复者.结果 43例中11例(25.6%)不仅恢复自主呼吸且完全康复,16例(37.2%)出现不同时间的自主呼吸但最终死亡,无自主呼吸恢复迹象者16例(37.2%).结论 因急性枕骨大孔疝致呼吸停止,应用快速细孔钻颅脑室引流,或幕上病变开颅清除减压术后,自主呼吸仍无恢复的患者,给予腰穿加压注液有可能使部分患者获救.

  8. 40 CFR 230.25 - Salinity gradients. (United States)


    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Salinity gradients. 230.25 Section 230... Physical and Chemical Characteristics of the Aquatic Ecosystem § 230.25 Salinity gradients. (a) Salinity... fresh or salt water may change existing salinity gradients. For example, partial blocking of...

  9. Successes and challenges of using whole exome sequencing to identify novel genes underlying an inherited predisposition for thoracic aortic aneurysms and acute aortic dissections. (United States)

    Milewicz, Dianna M; Regalado, Ellen S; Shendure, Jay; Nickerson, Deborah A; Guo, Dong-chuan


    Thoracic aortic aneurysms involving the aortic root and/or ascending aorta can lead to acute aortic dissections. Approximately 20% of patients with thoracic aortic aneurysms and dissections (TAAD) have a family history of the disease, referred to as familial TAAD (FTAAD) that can be inherited in an autosomal dominant manner with variable expression with respect to disease presentation, age of onset and associated features. Whole exome sequencing (WES) has been used to identify causative mutations in novel genes for TAAD. The strategy used to reduce the large number of rare variants identified using WES is to sequence distant relatives with TAAD and filter for heterozygous rare variants that are shared between the relatives, predicted to disrupt protein function and segregate with the TAAD phenotype in other family members. Putative genes are validated by identifying additional families with a causative mutation in the genes. This approach has successfully identified novel genes for FTAAD.

  10. Expression of acute phase proteins and inflammatory cytokines in mouse mammary gland following Staphylococcus aureus challenge and in response to milk accumulation

    DEFF Research Database (Denmark)

    Nazemi, Sasan; Aalbæk, Bent; Kjelgaard-Hansen, Mads


    We used a mouse model of pathogenic (Staphylococcus aureus) and non-pathogenic (teat sealing) mammary inflammation to investigate mRNA expression of several inflammatory cytokines and acute phase proteins (APP) in mammary tissue and liver, and the appearance of some of these factors in plasma...... in combination might provide a tool for diagnostic discrimination between mastitis caused by pathogenic invasion and milk accumulation, and hence allow for better targeting of antibiotic therapy. In comparison with mammary expression, expression of cytokines in liver tissue was up-regulated to a similar...... or lesser extent, whilst expression of APP was up-regulated to a much greater extent. The first appearance of increased cytokine and APP concentrations in plasma and of milk amyloid A (MAA) in milk occurred in advance of the measurable up-regulation of expression, hence their origin cannot be stated...

  11. Salinity triggers proline synthesis in peanut leaves


    Md. Ashrafuzzaman


    To investigate the magnitude of proline accumulation under different salinity levels, a salinity-imposed experiment was conducted. The peanut seedlings were cultured hydroponically for 7 days before imposing salinity and then grown further for another 7 days under salinity-loaded condition. Results showed that shoot dry matter, relative water content, chlorophyll and K+ decreased significantly with increasing salinity. In contrast, Na+, hydrogen peroxide and proline increased with increasing...

  12. Protocol for a human in vivo model of acute cigarette smoke inhalation challenge in smokers with COPD: monitoring the nasal and systemic immune response using a network biology approach (United States)

    Ross, Clare L; Galloway-Phillipps, Neil; Armstrong, Paul C; Mitchell, Jane A; Warner, Timothy D; Brearley, Christopher; Ito, Mari; Tunstall, Tanushree; Elkin, Sarah; Kon, Onn Min; Hansel, Trevor T; Paul-Clark, Mark J


    Introduction Cigarette smoke contributes to a diverse range of diseases including chronic obstructive pulmonary disease (COPD), cardiovascular disorders and many cancers. There currently is a need for human challenge models, to assess the acute effects of a controlled cigarette smoke stimulus, followed by serial sampling of blood and respiratory tissue for advanced molecular profiling. We employ precision sampling of nasal mucosal lining fluid by absorption to permit soluble mediators measurement in eluates. Serial nasal curettage was used for transcriptomic analysis of mucosal tissue. Methods and analysis Three groups of strictly defined patients will be studied: 12 smokers with COPD (GOLD Stage 2) with emphysema, 12 matched smokers with normal lung function and no evidence of emphysema, and 12 matched never smokers with normal spirometry. Patients in the smoking groups are current smokers, and will be given full support to stop smoking immediately after this study. In giving a controlled cigarette smoke stimulus, all patients will have abstained from smoking for 12 h, and will smoke two cigarettes with expiration through the nose in a ventilated chamber. Before and after inhalation of cigarette smoke, a series of samples will be taken from the blood, nasal mucosal lining fluid and nasal tissue by curettage. Analysis of plasma nicotine and metabolites in relation to levels of soluble inflammatory mediators in nasal lining fluid and blood, as well as assessing nasal transcriptomics, ex vivo blood platelet aggregation and leucocyte responses to toll-like receptor agonists will be undertaken. Implications Development of acute cigarette smoke challenge models has promise for the study of molecular effects of smoking in a range of pathological processes. Ethics and dissemination This study was approved by the West London National Research Ethics Committee (12/LO/1101). The study findings will be presented at conferences and will be reported in peer-reviewed journals

  13. Narrow and broad senses on salinity scale

    Institute of Scientific and Technical Information of China (English)


    The narrow sense and applicable limit of Practical Salinity Scale 1978 (PSS78) and volumetric titration using silver nitrate to measure the salinity of non-conservative oceanwater are discussed.The salinity obtained by electrical conductivity method and chlorinity salinity method obviously deviates from the absolute salinity (SA). The Density Salinity Scale (DSS98) proposed by the writers can be extensively used in conservative and non-conservative water samples.The merits of the density salinity scale are as follows,(1) The Density Salinity Scale is only related to seawater mass and its buoyant effect, and is not influenced by the variation in seawater composition, and therefore, has high reliability, and repeatability for salinity determination.(2) The salinity values measured by the DSS98 have a conservative property. For oceanwater samples the salinity values are the same as those determined by the PSS78; for non-conservative water samples (e.g. samples from industrial sources), the salinity values are close to the absolute salinity values in comparison with those measured by the PSS78 and the Knudsen method.(3)For a solution with given solute mass, the solution concentration can be converted into the corresponding salinity by the Density Salinity Scale using the expansion coefficient of the solution and the calibration coefficient of the partial molar volume of the solute.

  14. Acute pancreatitis (United States)

    ... its blood vessels. This problem is called acute pancreatitis. Acute pancreatitis affects men more often than women. Certain ... pancreatitis; Pancreas - inflammation Images Digestive system Endocrine glands Pancreatitis, acute - CT scan Pancreatitis - series References Forsmark CE. Pancreatitis. ...

  15. Cystitis - acute (United States)

    Uncomplicated urinary tract infection; UTI - acute cystitis; Acute bladder infection; Acute bacterial cystitis ... cause. Menopause also increases the risk for a urinary tract infection. The following also increase your chances of having ...

  16. The plasma membrane transport systems and adaptation to salinity. (United States)

    Mansour, Mohamed Magdy F


    Salt stress represents one of the environmental challenges that drastically affect plant growth and yield. Evidence suggests that glycophytes and halophytes have a salt tolerance mechanisms working at the cellular level, and the plasma membrane (PM) is believed to be one facet of the cellular mechanisms. The responses of the PM transport proteins to salinity in contrasting species/cultivars were discussed. The review provides a comprehensive overview of the recent advances describing the crucial roles that the PM transport systems have in plant adaptation to salt. Several lines of evidence were presented to demonstrate the correlation between the PM transport proteins and adaptation of plants to high salinity. How alterations in these transport systems of the PM allow plants to cope with the salt stress was also addressed. Although inconsistencies exist in some of the information related to the responses of the PM transport proteins to salinity in different species/cultivars, their key roles in adaptation of plants to high salinity is obvious and evident, and cannot be precluded. Despite the promising results, detailed investigations at the cellular/molecular level are needed in some issues of the PM transport systems in response to salinity to further evaluate their implication in salt tolerance.

  17. The effect of 3% and 6% hypertonic saline in viral bronchiolitis: a randomised controlled trial. (United States)

    Teunissen, Jasmijn; Hochs, Anne H J; Vaessen-Verberne, Anja; Boehmer, Annemie L M; Smeets, Carien C J M; Brackel, Hein; van Gent, René; Wesseling, Judith; Logtens-Stevens, Danielle; de Moor, Ronald; Rosias, Philippe P R; Potgieter, Steph; Faber, Marianne R; Hendriks, Han J E; Janssen-Heijnen, Maryska L G; Loza, Bettina F


    Bronchiolitis is a common disorder in young children that often results in hospitalisation. Except for a possible effect of nebulised hypertonic saline (sodium chloride), no evidence-based therapy is available. This study investigated the efficacy of nebulised 3% and 6% hypertonic saline compared with 0.9% hypertonic saline in children hospitalised with viral bronchiolitis. In this multicentre, double-blind, randomised, controlled trial, children hospitalised with acute viral bronchiolitis were randomised to receive either nebulised 3%, 6% hypertonic saline or 0.9% normal saline during their entire hospital stay. Salbutamol was added to counteract possible bronchial constriction. The primary endpoint was the length of hospital stay. Secondary outcomes were need for supplemental oxygen and tube feeding. From the 292 children included in the study (median age 3.4 months), 247 completed the study. The median length of hospital stay did not differ between the groups: 69 h (interquartile range 57), 70 h (IQR 69) and 53 h (IQR 52), for 3% (n=84) and 6% (n=83) hypertonic saline and 0.9% (n=80) normal saline, respectively, (p=0.29). The need for supplemental oxygen or tube feeding did not differ significantly. Adverse effects were similar in the three groups. Nebulisation with hypertonic saline (3% or 6% sodium chloride) although safe, did not reduce the length of stay in hospital, duration of supplemental oxygen or tube feeding in children hospitalised with moderate-to-severe viral bronchiolitis.

  18. Recurrence of a t(8;21-Positive Acute Myeloid Leukemia in the Form of a Granulocytic Sarcoma Involving Cranial Bones: A Diagnostic and Therapeutic Challenge

    Directory of Open Access Journals (Sweden)

    Ambra Di Veroli


    Full Text Available Granulocytic sarcoma (GS is a rare extramedullary solid tumor defined as an accumulation of myeloblasts or immature myeloid cells. It can cooccur with or precede the acute myeloid leukemia (AML as well as following treated AML. The incidence of GS in AML patients is 3–8% but it significantly rises in M2 FAB subtype AML. This variety of AML harbors t(8;21 in up to 20–25% of cases (especially in children and black ones of African origin and, at a molecular level, it is characterized by the generation of a fusion gene known as RUNX1-RUNX1T1. Approximately 10% of M2 AML patients will develop GS, as a consequence, the t(8;21 and the relative transcript represent the most common cytogenetic and molecular abnormalities in GS. FLT3-ITD mutation was rarely described in AML patients presenting with GS. FLT3 ITD is generally strongly associated with poor prognosis in AML, and is rarely reported in patients with t(8;21. GS presentation is extremely variable depending on organs involved; in general, cranial bones and sinus are very rarely affected sites. We report a rare case of GS occurring as a recurrence of a previously treated t(8;21, FLT3-ITD positive AML, involving mastoid bones and paravertebral tissues.

  19. Determining Salinity by Simple Means. (United States)

    Schlenker, Richard M.

    This paper describes the construction and use of a simple salinometer. The salinometer is composed, mainly, of a milliammeter and a battery and uses the measurement of current flow to determine the salinity of water. A complete list of materials is given, as are details of construction and operation of the equipment. The use of the salinometer in…

  20. Introduction of a Microsoft Excel-based unified electronic weekend handover document in Acute and General Medicine in a DGH: aims, outcomes and challenges. (United States)

    Kostelec, Pablo; Emanuele Garbelli, Pietro; Emanuele Garbelli, Pietro


    On-call weekends in medicine can be a busy and stressful time for junior doctors, as they are responsible for a larger pool of patients, most of whom they would have never met. Clinical handover to the weekend team is extremely important and any communication errors may have a profound impact on patient care, potentially even resulting in avoidable harm or death. Several senior clinical bodies have issued guidelines on best practice in written and verbal handover. These include: standardisation, use of pro forma documents prompting doctors to document vital information (such as ceiling of care/resuscitation status) and prioritisation according to clinical urgency. These guidelines were not consistently followed in our hospital site at the onset of 2014 and junior doctors were becoming increasingly dissatisfied with the handover processes. An initial audit of handover documents used across the medical division on two separate weekends in January 2014, revealed high variability in compliance with documentation of key information. For example, ceiling of care was documented for only 14-42% of patients and resuscitation status in 26-72% of patients respectively. Additionally, each ward used their own self-designed pro forma and patients were not prioritised by clinical urgency. Within six months from the introduction of a standardised, hospital-wide weekend handover pro forma across the medical division and following initial improvements to its layout, ceiling of therapy and resuscitation status were documented in approximately 80% of patients (with some minor variability). Moreover, 100% of patients in acute medicine and 75% of those in general medicine were prioritised by clinical urgency and all wards used the same handover pro forma.

  1. Building an international network for a primary care research program: reflections on challenges and solutions in the set-up and delivery of a prospective observational study of acute cough in 13 European countries

    Directory of Open Access Journals (Sweden)

    Veen Robert ER


    Full Text Available Abstract Background Implementing a primary care clinical research study in several countries can make it possible to recruit sufficient patients in a short period of time that allows important clinical questions to be answered. Large multi-country studies in primary care are unusual and are typically associated with challenges requiring innovative solutions. We conducted a multi-country study and through this paper, we share reflections on the challenges we faced and some of the solutions we developed with a special focus on the study set up, structure and development of Primary Care Networks (PCNs. Method GRACE-01 was a multi-European country, investigator-driven prospective observational study implemented by 14 Primary Care Networks (PCNs within 13 European Countries. General Practitioners (GPs recruited consecutive patients with an acute cough. GPs completed a case report form (CRF and the patient completed a daily symptom diary. After study completion, the coordinating team discussed the phases of the study and identified challenges and solutions that they considered might be interesting and helpful to researchers setting up a comparable study. Results The main challenges fell within three domains as follows: i selecting, setting up and maintaining PCNs; ii designing local context-appropriate data collection tools and efficient data management systems; and iii gaining commitment and trust from all involved and maintaining enthusiasm. The main solutions for each domain were: i appointing key individuals (National Network Facilitator and Coordinator with clearly defined tasks, involving PCNs early in the development of study materials and procedures. ii rigorous back translations of all study materials and the use of information systems to closely monitor each PCNs progress; iii providing strong central leadership with high level commitment to the value of the study, frequent multi-method communication, establishing a coherent ethos

  2. Bulk Moisture and Salinity Sensor (United States)

    Nurge, Mark; Monje, Oscar; Prenger, Jessica; Catechis, John


    Measurement and feedback control of nutrient solutions in plant root zones is critical to the development of healthy plants in both terrestrial and reduced-gravity environments. In addition to the water content, the amount of fertilizer in the nutrient solution is important to plant health. This typically requires a separate set of sensors to accomplish. A combination bulk moisture and salinity sensor has been designed, built, and tested with different nutrient solutions in several substrates. The substrates include glass beads, a clay-like substrate, and a nutrient-enriched substrate with the presence of plant roots. By measuring two key parameters, the sensor is able to monitor both the volumetric water content and salinity of the nutrient solution in bulk media. Many commercially available moisture sensors are point sensors, making localized measurements over a small volume at the point of insertion. Consequently, they are more prone to suffer from interferences with air bubbles, contact area of media, and root growth. This makes it difficult to get an accurate representation of true moisture content and distribution in the bulk media. Additionally, a network of point sensors is required, increasing the cabling, data acquisition, and calibration requirements. measure the dielectric properties of a material in the annular space of the vessel. Because the pore water in the media often has high salinity, a method to measure the media moisture content and salinity simultaneously was devised. Characterization of the frequency response for capacitance and conductance across the electrodes was completed for 2-mm glass bead media, 1- to 2-mm Turface (a clay like media), and 1- to 2-mm fertilized Turface with the presence of root mass. These measurements were then used to find empirical relationships among capacitance (C), the dissipation factor (D), the volumetric water content, and the pore water salinity.

  3. Acute brain hemorrhage in dengue

    Institute of Scientific and Technical Information of China (English)

    Somsri Wiwanitkit; Viroj Wiwanitkit


    Dengue is a tropical arboviral infection that can have severe hemorrhagic complication.Acute brain hemorrhage in dengue is rare and is a big challenge in neurosurgery.To perform surgery for management of acute brain hemorrhage in dengue is a controversial issue.Here, the authors try to summarize the previous reports on this topic and compare neurosurgery versus conservative management.

  4. Clinical research about the curative effect of hypertonic saline on acute intracranial hypertension caused by craniocerebral injury%高渗盐水抢救颅脑损伤所致急性颅内高压的临床研究

    Institute of Scientific and Technical Information of China (English)

    刘万宝; 刘剑; 乔着意; 赵庆波; 王梅


    目的 探讨高渗盐水(hypertonic saline,HS)在急诊科抢救颅脑损伤所致急性颅内高压患者首次降颅压治疗中的临床疗效.方法 颅脑损伤所致急性颅内高压患者60例,随机分为3%HS组(20例)、10%HS组(20例)和20%甘露醇(mannitol,MT)组(20例).3%HS组静脉给予3%HS 260 mL,10%HS组静脉给予10%HS 80 mL,MT组静脉给予20%MT 250 mL,并于用药前及用药后30、60、90 min和2、3、4、5 h监测颅内压(intracranial pressure,ICP)、平均动脉压(mean artery pressure,MAP),记录尿量,观察生命体征变化,监测血生化指标.结果 ①HS组于用药后30 min ICP达到最大降幅,显著早于MT组(P0.05).③静脉快速滴注3%HS、10%HS和20%MT后脑灌注压(CPP)均显著升高(P0.05),但3%HS作用持续时间较10%HS、20%MT显著延长(P<0.05).结论 ①与MT比较,HS抢救颅脑损伤所致急性颅内高压起效更快、更持久,维持ICP更平稳.②两种浓度HS都能显著升高MAP,具有显著扩容作用.③三组均能升高CPP,以3%HS持续时间较长.%Objective To investigate the curative effect of hypertonic saline (HS) on the patients with acute intracranial hypertension caused by craniocerebral injury in emergency department.Methods Patients with acute intracranial hypertension caused by craniocerebral injury were divided into three groups including 3% HS group, 10% HS group and 20% mannitol (MT) group randomly.The intracranial pressure(ICP), mean arterial pressure (MAP), blood pressure(BP), cerebral perfusion pressure( CPP), urine output and blood biochemical parameters were recorded before the treatment and at 30, 60, 90 min and 2, 3, 4, 5 h after 3% HS 260 mL, 10% HS 80 mL and 20% MT 250 mL treatment respectively.Results ①The ICP decreased greatly at 30 min after HS treatment, which was earlier than in MT group(P < 0.05).Moreover, decreased ICP of 3% HS group maintained for 4 h,which was better than other groups(P < 0.05).②The MAP increased after treatment in HS

  5. Acute Bronchitis (United States)

    ... Smoking also slows down the healing process. Acute bronchitis treatment Most cases of acute bronchitis can be treated at home.Drink fluids, but ... bronchial tree. Your doctor will decide if this treatment is right for you. Living with acute bronchitis Most cases of acute bronchitis go away on ...

  6. Pathophysiological and immune cell responses in calves prior to and following lung challenge with formalin-killed Pasteurella multocida biotype A:3 and protection studies involving subsequent homologous live challenge. (United States)

    Dowling, A; Hodgson, J C; Dagleish, M P; Eckersall, P D; Sales, J


    Pneumonic pasteurellosis is a common respiratory infection in cattle that has major economic and welfare implications world-wide and the incidence in the UK due to Pasteurella multocida, currently the same as that associated with Mannheimia haemolytica, is increasing. Whereas much is known regarding the pathogenesis of M. haemolytica infections little information is available on the pathogenic process of pasteurellosis initiated by P. multocida. In the present work calf systemic and innate immune responses to intratracheal challenge with formalin-killed P. multocida biotype A:3 and to subsequent experimental lung infection with live P. multocida were investigated. Eight-week-old calves were challenged intratracheally on day 0 with either 10(9) colony forming units (cfu) of formalin-killed P. multocida biotype A:3 in 300 ml saline (n = 10) or 300 ml saline alone (n = 10), followed, at day 21, by challenge with 10(9) cfu live P. multocida. Pathophysiological and lung phagocyte responses were assessed by clinical monitoring, sequential lung lavage and blood sampling. Results for samples obtained before, during and after challenge showed clinical and acute phase protein responses to both bacterial culture and saline control treatments, although higher responses were associated with bacterial challenge. Phagocytosis of P. multocida during 1h incubation periods with lavaged cells in vitro was unaffected by exposure in vivo to killed P. multocida and there was evidence that P. multocida was able to survive intracellularly during this assay. There was no indication that lung exposure to formalin-killed P. multocida conferred protection against subsequent homologous live challenge.

  7. The Effect of Salinity on Egg Development and Viability of Schistocephalus solidus (Cestoda: Diphyllobothriidea). (United States)

    Simmonds, Natalie E; Barber, Iain


    Schistocephalus solidus plerocercoids commonly infect three-spined stickleback Gasterosteus aculeatus populations in brackish and freshwaters, but infections are typically absent from marine populations. Here we provide an experimental test of the salinity tolerance of S. solidus eggs, to determine the role of salinity in limiting the distribution of infection in coastal zones. We find that S. solidus eggs, derived from the in vitro culture of 3 different plerocercoids, developed normally in salinities of up to 12.5‰, but above this egg viability dropped rapidly, and no egg hatching was observed at salinities above 20‰. Our results are consistent with the distribution of infections in natural stickleback populations and add resolution to previous descriptive observations on salinity tolerance in S. solidus. They also demonstrate that S. solidus presents a novel disease challenge to marine populations of three-spined sticklebacks entering brackish and freshwater environments.

  8. Saline Water Irrigation Scheduling Through a Crop-Water-Salinity Production Function and a Soil-Water-Salinity Dynamic Model

    Institute of Scientific and Technical Information of China (English)

    WANG Yang-Ren; KANG Shao-Zhong; LI Fu-heng; ZHANG Lu; ZHANG Jian-Hua


    Using a crop-water-salinity production function and a soil-water-salinity dynamic model, optimal irrigation scheduling was developed to maximize net return per irrigated area. Plot and field experiments were used to obtain the crop water sensitivity index, the salinity sensitivity index, and other parameters. Using data collected during 35 years to calculate the 10-day mean precipitation and evaporation, the variation in soil salinity concentrations and in the yields of winter wheat and cotton were simulated for 49 irrigation scheduling that were combined from 7 irrigation schemes over 3 irrigation dates and 7 salinity concentrations of saline irrigation water (fresh water and 6 levels of saline water). Comparison of predicted results with irrigation data obtained from a large area of the field showed that the model was valid and reliable. Based on the analysis of the investment cost of the irrigation that employed deep tube wells or shallow tube wells, a saline water irrigation schedule and a corresponding strategy for groundwater development and utilization were proposed. For wheat or cotton, if the salinity concentration was higher than 7.0 g L-1 in groundwater, irrigation was needed with only fresh water; if about 5.0 g L-1, irrigation was required twice with fresh water and once with saline water; and if not higher than 3.0 g L-1, irrigation could be solely with saline water.

  9. The Aquarius Salinity Retrieval Algorithm (United States)

    Meissner, Thomas; Wentz, Frank; Hilburn, Kyle; Lagerloef, Gary; Le Vine, David


    The first part of this presentation gives an overview over the Aquarius salinity retrieval algorithm. The instrument calibration [2] converts Aquarius radiometer counts into antenna temperatures (TA). The salinity retrieval algorithm converts those TA into brightness temperatures (TB) at a flat ocean surface. As a first step, contributions arising from the intrusion of solar, lunar and galactic radiation are subtracted. The antenna pattern correction (APC) removes the effects of cross-polarization contamination and spillover. The Aquarius radiometer measures the 3rd Stokes parameter in addition to vertical (v) and horizontal (h) polarizations, which allows for an easy removal of ionospheric Faraday rotation. The atmospheric absorption at L-band is almost entirely due to molecular oxygen, which can be calculated based on auxiliary input fields from numerical weather prediction models and then successively removed from the TB. The final step in the TA to TB conversion is the correction for the roughness of the sea surface due to wind, which is addressed in more detail in section 3. The TB of the flat ocean surface can now be matched to a salinity value using a surface emission model that is based on a model for the dielectric constant of sea water [3], [4] and an auxiliary field for the sea surface temperature. In the current processing only v-pol TB are used for this last step.

  10. Impact of nutrition and salinity changes on biological performances of green and white sturgeon


    Pedro G Vaz; Ermias Kebreab; Hung, Silas S. O.; Fadel, James G.; Seunghyung Lee; Fangue, Nann A.


    Copyright: © 2015 Vaz et al. Green and white sturgeon are species of high conservational and economic interest, particularly in the San Francisco Bay Delta (SFBD) for which significant climate changederived alterations in salinity and nutritional patterns are forecasted. Although there is paucity of information, it is critical to test the network of biological responses underlying the capacity of animals to tolerate current environmental changes. Through nutrition and salinity challenges, cli...

  11. mRNA expression profiles of heat shock proteins of wild and salinity-tolerant swimming crabs, Portunus trituberculatus, subjected to low salinity stress. (United States)

    Bao, X N; Mu, C K; Zhang, C; Wang, Y F; Song, W W; Li, R H; Wang, C L


    Challenged by the low salinity, 4 parts per thousand (4 ppt), for 72h, the survivals of swimming crabs (Portunus trituberculatus) were collected as the screened group (SG, tolerant to low salinity). Aiming at identifying the mechanism of low salinity tolerance, quantitative real-time PCR was employed to investigate the expression profiles of 4 HSP genes (HSP60, HSP70, HSP90-1, HSP90-2) in the hepatopancreas of wild (WG) and screened (SG) groups of P. trituberculatus exposed to low salinity (4 ppt). The results showed that 3 of the candidate genes (HSP60, HSP70, HSP90-1) exhibited similarly downregulated expression profiles in the first 3 h (P crabs. The results indicate that HSP genes are involved in the adaptation of crabs to low salinity exposure, and that different HSPs have diverse functions in response to low salinity stress in P. trituberculatus. In addition, HSP expression in SG indicates that this group is more tolerant to low salinity conditions compared to WG.

  12. Growth curve registration for evaluating salinity tolerance in barley

    KAUST Repository

    Meng, Rui


    Background: Smarthouses capable of non-destructive, high-throughput plant phenotyping collect large amounts of data that can be used to understand plant growth and productivity in extreme environments. The challenge is to apply the statistical tool that best analyzes the data to study plant traits, such as salinity tolerance, or plant-growth-related traits. Results: We derive family-wise salinity sensitivity (FSS) growth curves and use registration techniques to summarize growth patterns of HEB-25 barley families and the commercial variety, Navigator. We account for the spatial variation in smarthouse microclimates and in temporal variation across phenotyping runs using a functional ANOVA model to derive corrected FSS curves. From FSS, we derive corrected values for family-wise salinity tolerance, which are strongly negatively correlated with Na but not significantly with K, indicating that Na content is an important factor affecting salinity tolerance in these families, at least for plants of this age and grown in these conditions. Conclusions: Our family-wise methodology is suitable for analyzing the growth curves of a large number of plants from multiple families. The corrected curves accurately account for the spatial and temporal variations among plants that are inherent to high-throughput experiments.

  13. Protective Effect of Genistein on Lipopolysaccharide-induced Acute Lung Injury in Rats

    Institute of Scientific and Technical Information of China (English)

    LI Xingwang; XU Tao; LIAN Qingquan; ZENG Bangxiong; ZHANG Bing; XIE Yubo


    To investigate the protective effect of genistein on endotoxin-induced acute lung injury in rats, and explore the underlying mechanisms, 32 male Sprague-Dawley rats were randomly divided into 4 experimental groups: saline control, genistein alone, lipopolysaccaride alone, and genistein pretreatment. Each treatment group consisted of eight animals. Animals were observed for 6 h after LPS challenge, and the wet/dry (W/D) weight ratio of the lung and bronchoalveolar lavage fluid(BALF) protein content were used as a measure of lung injury. Neutrophil recruitment and activation were evaluated by BALF cellularity and myeloperoxidase (MPO) activity. RT-PCR analysis was performed in lung tissue to assess gene expression of ICAM-1. The histopathological changes were also observed using the HE staining of lung tissue. Our results showed that lung injury parameters, including the wet/dry weight ratio and protein content in BALF, were significantly higher in the LPS alone group than in the saline control group (P<0.01). In the LPS alone group, a larger number of neutrophils and greater MPO activity in cell-free BAL and lung homogenates were observed when compared with the saline control group (P<0.01). There was a significant increase in lung ICAM-1 mRNA in response to LPS challenge (P< 0. 01, group L versus group S).Genistein pretreatment significantly attenuated LPS-induced changes in these indices. LPS caused extensive lung damage, which was also lessened after genistein pretreatment. All above-mentioned parameters in the genistein alone group were not significantly different from those of the saline control group. It is concluded that genistein pretreatment attenuated LPS-induced lung injury in rats.This beneficial effect of genistein may involves, in part, an inhibition of neutrophilic recruitment and activity, possibly through an inhibition of lung ICAM-1 expression.

  14. Hydrogeologic processes in saline systems: Playas, sabkhas, and saline lakes (United States)

    Yechieli, Y.; Wood, W.W.


    Pans, playas, sabkhas, salinas, saline lakes, and salt flats are hydrologically similar, varying only in their boundary conditions. Thus, in evaluating geochemical processes in these systems, a generic water and solute mass-balance approach can be utilized. A conceptual model of a coastal sabkha near the Arabian Gulf is used as an example to illustrate the various water and solute fluxes. Analysis of this model suggests that upward flux of ground water from underlying formations could be a major source of solutes in the sabkha, but contribute only a small volume of the water. Local rainfall is the main source of water in the modeled sabkha system with a surprisingly large recharge-to-rainfall ratio of more than 50%. The contribution of seawater to the solute budget depends on the ratio of the width of the supratidal zone to the total width and is generally confined to a narrow zone near the shoreline of a typical coastal sabkha. Because of a short residence time of water, steady-state flow is expected within a short time (50,000 years). The solute composition of the brine in a closed saline system depends largely on the original composition of the input water. The high total ion content in the brine limits the efficiency of water-rock interaction and absorption. Because most natural systems are hydrologically open, the chemistry of the brines and the associated evaporite deposits may be significantly different than that predicted for hydrologically closed systems. Seasonal changes in temperature of the unsaturated zone cause precipitation of minerals in saline systems undergoing evaporation. Thus, during the hot dry season months, minerals exhibit retrograde solubility so that gypsum, anhydrite and calcite precipitate. Evaporation near the surface is also a major process that causes mineral precipitation in the upper portion of the unsaturated zone (e.g. halite and carnallite), provided that the relative humidity of the atmosphere is less than the activity of water

  15. Saline Ground Water and Irrigation Water on Root Zone Salinity

    Directory of Open Access Journals (Sweden)

    T. Subramani


    Full Text Available Salinisation of land and rivers is a problem of national importance in India. Appropriate land management options to alleviate salinisation should be chosen with knowledge of the effects of land management on stream flow, stream salinity, stream salt load and land productivity. The Management of Catchment Salinisation (MCS modelling approach has been described in earlier work. It links a one-dimensional soil water model with a groundwater model to investigate the effects of management options in study areas of approximately 50 km2. The one dimensional model is used to characterize the annual soil water balance as a function of underlying aquifer Vpotential for all required combinations of soil, vegetation and groundwater salinity. It includes the effect of salt accumulation on plant water use. A groundwater model is then used to estimate the depth to water table across the study area that reflects the topography, hydrogeology and the distribution of vegetation. The MCS model is used to investigate the potential effects of future land use scenarios on catchment salt and water balance. Land use scenarios that have been considered include: forest plantations, revegetation with native trees and shrubs, and development of small areas of crops (10 to 20 ha irrigated with groundwater. This project focuses on the development of small crop areas irrigated with groundwater and investigates the sustainability of these schemes. It also compares the reduction of catchment salt load export under irrigation development with the reduction under afforestation

  16. Effect of Cu toxicity at different salinity on selective group of juvenile pompano Trachinotus ovatus

    Institute of Scientific and Technical Information of China (English)

    OU You-jun; LI Jia-er; CAI Wen-chao


    Effects of copper toxicity and salinity shock on selective group of juvenile pompano Trachinotus ovatus were investigated. The fish were exposed to different Cu2+ concentrations of 0 (blank), 0.02 (C1), 0.05 (C2), 0.10 (C3), and 0.15 mg·L-1 (C4) at a salinity of 10‰ or 40‰ for 96 h, with the salinity of 29‰ as the control. The results showed that the effects of the acute salinity stimulation to survival rates of pompano between control (29‰) and lower or higher salinity for 96 h were not significant (p>0.05). However, the survival rates in each treatment were decreased with the increase of Cu2+concentration. The dominant factor influencing body moisture of the fish was salinity, and there was no sign that body moisture was correlated with exposure to Cu2+. The gill lamellas in high level of Cu2+concentration (C4 treatments) were abnormal under the salinity of 40‰ and extremely curly under the salinity of 10‰. Hemorrhage in gill was observed in the two C4 treatments. Under transmission electron microscope, pillar cells in gill lamellas appeared deformed and ruptured in some areas of the epithelia in the higher concentration of Cu2+, resulting in the death of the fish due to the destruction of gill tissue, elevation of the arithmetic mean distance from water to blood, the decrease of oxygen diffusion capacity, and other physiological functions. These findings indicate that the pompano might suffer much more pressure when encountered with Cu2+ pollution and low salinity.

  17. Adopted: A practical salinity scale (United States)

    The Unesco/ICES/SCOR/IAPSO Joint Panel on Oceanographic Tables and Standards has recommended the adoption of a Practical Salinity Scale, 1978, and a corresponding new International Equation of State of Seawater, 1980. A full account of the research leading to their recommendation is available in the series Unesco Technical Papers in Marine Science.The parent organizations have accepted the panel's recommendations and have set January 1, 1982, as the date when the new procedures, formulae, and tables should replace those now in use.

  18. Population specific salinity tolerance in eelgrass (Zostera marina)

    DEFF Research Database (Denmark)

    Salo, Tiina Elina; Pedersen, Morten Foldager; Boström, Christoffer


    Salinity is one of the main factors impacting distribution of marine plants and sub-optimal salinities may result in increased resource use and decreased production.We studied the performance and salinity tolerance of eelgrass (Zostera marina L.) originating from two regions with different ambient...... salinities: a low saline (salinity 6) and a high saline (salinity 20) population. Plants fromboth populationswere exposed to a series of fixed salinities (2, 4, 6, 9, 12.5, 15, 20 and 25) for 5 weeks. Both plant origin and salinity affected plant performance significantly. Plant production decreasedwith...... decreasing salinity in both populations,while mortality increased in lowsalinity only in plants originating from the high saline population. The better performance of the low saline population in the lowest salinities indicates a horizontal shift in salinity tolerance among populationswith different origin...

  19. High salinity tolerance of the Red Sea coral Fungia granulosa under desalination concentrate discharge conditions: an in situ photophysiology experiment

    KAUST Repository

    Van Der Merwe, Riaan


    Seawater reverse osmosis desalination concentrate may have chronic and/or acute impacts on the marine ecosystems in the near-field area of the discharge. Environmental impact of the desalination plant discharge is supposedly site- and volumetric- specific, and also depends on the salinity tolerance of the organisms inhabiting the water column in and around a discharge environment. Scientific studies that aim to understand possible impacts of elevated salinity levels are important to assess detrimental effects to organisms, especially for species with no mechanism of osmoregulation, e.g., presumably corals. Previous studies on corals indicate sensitivity toward hypo- and hyper-saline environments with small changes in salinity already affecting coral physiology. In order to evaluate sensitivity of Red Sea corals to increased salinity levels, we conducted a long-term (29 days) in situ salinity tolerance transect study at an offshore seawater reverse osmosis (SWRO) discharge on the coral Fungia granulosa. While we measured a pronounced increase in salinity and temperature at the direct outlet of the discharge structure, effects were indistinguishable from the surrounding environment at a distance of 5 m. Interestingly, corals were not affected by varying salinity levels as indicated by measurements of the photosynthetic efficiency. Similarly, cultured coral symbionts of the genus Symbiodinium displayed remarkable tolerance levels in regard to hypo- and hypersaline treatments. Our data suggest that increased salinity and temperature levels from discharge outlets wear off quickly in the surrounding environment. Furthermore, F. granulosa seem to tolerate levels of salinity that are distinctively higher than reported for other corals previously. It remains to be determined whether Red Sea corals in general display increased salinity tolerance, and whether this is related to prevailing levels of high(er) salinity in the Red Sea in comparison to other oceans.

  20. Acute pancreatitis

    Directory of Open Access Journals (Sweden)

    Bo-Guang Fan


    Full Text Available Background : Acute pancreatitis continues to be a serious illness, and the patients with acute pancreatitis are at risk to develop different complications from ongoing pancreatic inflammation. Aims : The present review is to highlight the classification, treatment and prognosis of acute pancreatitis. Material & Methods : We reviewed the English-language literature (Medline addressing pancreatitis. Results : Acute pancreatitis is frequently caused by gallstone disease or excess alcohol ingestion. There are a number of important issues regarding clinical highlights in the classification, treatment and prognosis of acute pancreatitis, and treatment options for complications of acute pancreatitis including pancreatic pseudocysts. Conclusions : Multidisciplinary approach should be used for the management of the patient with acute pancreatitis.

  1. Acute pancreatitis

    Directory of Open Access Journals (Sweden)

    Bo-Guang Fan


    Full Text Available Background: Acute pancreatitis continues to be a serious illness, and the patients with acute pancreatitis are at risk to develop different complications from ongoing pancreatic inflammation. Aims: The present review is to highlight the classification, treatment and prognosis of acute pancreatitis. Material & Methods: We reviewed the English-language literature (Medline addressing pancreatitis. Results: Acute pancreatitis is frequently caused by gallstone disease or excess alcohol ingestion. There are a number of important issues regarding clinical highlights in the classification, treatment and prognosis of acute pancreatitis, and treatment options for complications of acute pancreatitis including pancreatic pseudocysts. Conclusions: Multidisciplinary approach should be used for the management of the patient with acute pancreatitis.

  2. ENSO signature in the SMOS sea surface salinity maps (United States)

    Ballabrera, J.; Umbert, M.; Hoareau, N.; Turiel, A.; Font, J.


    Until recently, the role of salinity observations in the operational simulation and prediction of ENSO was neglected because of the historical lack of observations and because leading intermediate coupled models had significant predictive skill without directly accounting for salinity effects. In Ballabrera-Poy et al., (2002), the potential role of sea surface salinity (SSS) observations on the statistical predictions of ENSO was investigated. It was shown that, although SSS observations would play little role in statistical nowcasts of ENSO, they would provide a significant role in the 6-12 month predictions. The European Space Agency (ESA) Soil Moisture and Ocean Salinity (SMOS) Earth Explorer opportunity mission was launched on November 2, 2009, becoming the first satellite mission addressing the challenge of measuring SSS from space with the help of MIRAS (Microwave Imaging Radiometer with Aperture Synthesis), a novel two-dimensional interferometer operating at L-band (1.4 GHz). Although the L-band frequency is the optimal for ocean salinity measurements, the retrieval of SSS information requires special care because of the low sensitivity of the brightness temperature to SSS: from 0.2-0.8 K per salinity unit. Maps of 10-day averages of SSS in 1x1 degree boxes are distributed by the SMOS Barcelona Expert Centre on Radiometric Calibration and Ocean Salinity (SMOS-BEC, These maps are derived from the SMOS reprocessing campaign released to the SMOS user community in March 2011, and span the period from January 2010 through December 2011. The current accuracy of these SSS maps ranges from 0.2-0.4, depending on the ocean region being considered (Umbert et al., 2012). During the period of the reprocessing campaign, the equatorial Pacific has been in a quasi-continuous La Niña state. During the cold phases of ENSO, positive anomalies of SSS are expected with a largest anomalous values in the western warm-fresh pool. The anomalies

  3. IGF-I and branchial IGF receptor expression and localization during salinity acclimation in striped bass

    DEFF Research Database (Denmark)

    Tipsmark, Christian Kølbaek; Luckenbach, John Adam; Madsen, Steffen


    The initial response of the IGF-I system and the expression and cellular localization of IGF type-I receptor (IGF-IR) were studied in the gill of a euryhaline teleost during salinity acclimation. Exposure of striped bass (Morone saxatilis) to hyperosmotic and hypoosmotic challenges induced small...... in either plasma IGF-I, liver, or gill IGF-I mRNA, or gill IGF-IR mRNA levels. In a separate experiment, FW-acclimated fish were injected with saline or IGF-I prior to a 24-h SW challenge. Rapid regain of osmotic balance following SW transfer was hindered by IGF-I. Immunohistochemistry revealed...

  4. A global algorithm for estimating Absolute Salinity

    Directory of Open Access Journals (Sweden)

    T. J. McDougall


    Full Text Available The International Thermodynamic Equation of Seawater – 2010 has defined the thermodynamic properties of seawater in terms of a new salinity variable, Absolute Salinity, which takes into account the spatial variation of the composition of seawater. Absolute Salinity more accurately reflects the effects of the dissolved material in seawater on the thermodynamic properties (particularly density than does Practical Salinity.

    When a seawater sample has standard composition (i.e. the ratios of the constituents of sea salt are the same as those of surface water of the North Atlantic, Practical Salinity can be used to accurately evaluate the thermodynamic properties of seawater. When seawater is not of standard composition, Practical Salinity alone is not sufficient and the Absolute Salinity Anomaly needs to be estimated; this anomaly is as large as 0.025 g kg−1 in the northernmost North Pacific. Here we provide an algorithm for estimating Absolute Salinity Anomaly for any location (x, y, p in the world ocean.

    To develop this algorithm, we used the Absolute Salinity Anomaly that is found by comparing the density calculated from Practical Salinity to the density measured in the laboratory. These estimates of Absolute Salinity Anomaly however are limited to the number of available observations (namely 811. In order to provide a practical method that can be used at any location in the world ocean, we take advantage of approximate relationships between Absolute Salinity Anomaly and silicate concentrations (which are available globally.

  5. Relating river discharges to salinity changes (United States)

    Xie, X.; Liu, W. T.


    New river discharge data are brought together with spacebased sea surface salinity measurements by Aquarius and SMOS to demonstrate the role of river discharge in salinity changes near three river mouths: the Mississippi, the Ganges, and the Amazon. The characteristics of the seasonal cycle and the year-to-year changes of the river runoff are described. Various versions of the satellite salinity data are compared. The relative roles of river discharge, surface water flux, and horizontal advection in changing surface salinity in regions near the river mouths are examined. Satellite measurements of SSS clearly track movements of the fresh water from river discharges. Besides the river discharge, E-P plays an important role in the seasonal salinity variation near the Ganges and Irrawaddy River mouths. For the Mississippi and Amazon river mouths, central and eastern ITCZ, E-P contributes very little to the salinity seasonal change. In the central and eastern ITCZ, contribution of advection to the salinity tendency is clearly identified. Both salinity and salinity tendency are dominated by semi-annual cycle in the Atlantic ITCZ between 5ºN to 9ºN, whereas annual cycle dominates at other latitudes.

  6. Soil Salinity Mapping Using Multitemporal Landsat Data (United States)

    Azabdaftari, A.; Sunar, F.


    Soil salinity is one of the most important problems affecting many areas of the world. Saline soils present in agricultural areas reduce the annual yields of most crops. This research deals with the soil salinity mapping of Seyhan plate of Adana district in Turkey from the years 2009 to 2010, using remote sensing technology. In the analysis, multitemporal data acquired from LANDSAT 7-ETM+ satellite in four different dates (19 April 2009, 12 October 2009, 21 March 2010, 31 October 2010) are used. As a first step, preprocessing of Landsat images is applied. Several salinity indices such as NDSI (Normalized Difference Salinity Index), BI (Brightness Index) and SI (Salinity Index) are used besides some vegetation indices such as NDVI (Normalized Difference Vegetation Index), RVI (Ratio Vegetation Index), SAVI (Soil Adjusted Vegetation Index) and EVI (Enhamced Vegetation Index) for the soil salinity mapping of the study area. The field's electrical conductivity (EC) measurements done in 2009 and 2010, are used as a ground truth data for the correlation analysis with the original band values and different index image bands values. In the correlation analysis, two regression models, the simple linear regression (SLR) and multiple linear regression (MLR) are considered. According to the highest correlation obtained, the 21st March, 2010 dataset is chosen for production of the soil salinity map in the area. Finally, the efficiency of the remote sensing technology in the soil salinity mapping is outlined.


    Directory of Open Access Journals (Sweden)

    A. Azabdaftari


    Full Text Available Soil salinity is one of the most important problems affecting many areas of the world. Saline soils present in agricultural areas reduce the annual yields of most crops. This research deals with the soil salinity mapping of Seyhan plate of Adana district in Turkey from the years 2009 to 2010, using remote sensing technology. In the analysis, multitemporal data acquired from LANDSAT 7-ETM+ satellite in four different dates (19 April 2009, 12 October 2009, 21 March 2010, 31 October 2010 are used. As a first step, preprocessing of Landsat images is applied. Several salinity indices such as NDSI (Normalized Difference Salinity Index, BI (Brightness Index and SI (Salinity Index are used besides some vegetation indices such as NDVI (Normalized Difference Vegetation Index, RVI (Ratio Vegetation Index, SAVI (Soil Adjusted Vegetation Index and EVI (Enhamced Vegetation Index for the soil salinity mapping of the study area. The field’s electrical conductivity (EC measurements done in 2009 and 2010, are used as a ground truth data for the correlation analysis with the original band values and different index image bands values. In the correlation analysis, two regression models, the simple linear regression (SLR and multiple linear regression (MLR are considered. According to the highest correlation obtained, the 21st March, 2010 dataset is chosen for production of the soil salinity map in the area. Finally, the efficiency of the remote sensing technology in the soil salinity mapping is outlined.

  8. Salinity Temperature and Roughness Remote Scanner (STARRS) (United States)

    Federal Laboratory Consortium — FUNCTION: Provides spatially continuous high-resolution surface salinity imagery in a synoptic manner from small aircraft. Its output complements data collected from...

  9. Soil salinity detection from satellite image analysis: an integrated approach of salinity indices and field data. (United States)

    Morshed, Md Manjur; Islam, Md Tazmul; Jamil, Raihan


    This paper attempts to detect soil salinity from satellite image analysis using remote sensing and geographic information system. Salinity intrusion is a common problem for the coastal regions of the world. Traditional salinity detection techniques by field survey and sampling are time-consuming and expensive. Remote sensing and geographic information system offer economic and efficient salinity detection, monitoring, and mapping. To predict soil salinity, an integrated approach of salinity indices and field data was used to develop a multiple regression equation. The correlations between different indices and field data of soil salinity were calculated to find out the highly correlated indices. The best regression model was selected considering the high R (2) value, low P value, and low Akaike's Information Criterion. About 20% variation was observed between the field data and predicted EC from the satellite image analysis. The precision of this salinity detection technique depends on the accuracy and uniform distribution of field data.

  10. Pain patterns after distension of the gallbladder in patients with acute cholecystitis

    DEFF Research Database (Denmark)

    Middelfart, H V; Jensen, P; Højgaard, L;


    and the cystic duct opening pressure. METHODS: Twelve patients (nine women, three men) treated with cholecystostomy for acute cholecystitis were investigated. Simultaneous cholescintigraphy and measurement of changes in intraluminal gallbladder pressure after injections of saline through a gallbladder catheter...

  11. Acute cholecystitis


    Halpin, Valerie


    Acute cholecystitis causes unremitting right upper quadrant pain, anorexia, nausea, vomiting, and fever, and if untreated can lead to perforations, abscess formation, or fistulae. About 95% of people with acute cholecystitis have gallstones.It is thought that blockage of the cystic duct by a gallstone or local inflammation can lead to acute cholecystitis, but we don't know whether bacterial infection is also necessary.

  12. Effects of feed restriction on salinity tolerance in white sturgeon (Acipenser transmontanus). (United States)

    Lee, Seunghyung; Fadel, James G; Haller, Liran Y; Verhille, Christine E; Fangue, Nann A; Hung, Silas S O


    A multistressor study was conducted to investigate interactive effects of nutritional status and salinity on osmoregulation of juvenile white sturgeon. Our hypothesis was that lower nutritional status would decrease the salinity tolerance of juvenile white sturgeon. A four-week feed restriction (12.5%, 25%, 50%, 100% of optimum feeding rate: OFR defined as the rate (% body weight per day) at which growth is maximal) trial was performed, and relevant indices of nutritional status were measured. Following the trial, sturgeon were acutely exposed to various salinities (0, 8, 16, 24 ppt) for 120 h, and relevant osmoregulatory measurements were made at 12, 72, and 120 h post-salinity exposures. The feed-restriction trial resulted in a graded nutritional response with the most feed-restricted group (12.5% OFR) showing the lowest nutritional status. The salinity exposure trial showed clear evidence that lower nutritional status decreased the salinity tolerance of juvenile white sturgeon. Increasing salinities resulted in significant alterations in osmoregulatory indices of all feeding groups; however, a significantly slower acclimatory response to 24 ppt was detected in the most feed-restricted group compared to the non-feed-restricted group (100% OFR). Furthermore, evaluation of the effect of nutritional status on the relationship between osmoregulatory measurements and body size showed that there was a significant negative relationship between osmoregulatory performance and body size within the most feed-restricted group. This suggests that there is a certain body size range (200-300 g based on our finding) where juvenile white sturgeon can maximize osmoregulatory capacity at a salinity of 24 ppt.

  13. Investigations in Marine Chemistry: Salinity II. (United States)

    Schlenker, Richard M.

    Presented is a science activity in which the student investigates methods of calibration of a simple conductivity meter via a hands-on inquiry technique. Conductivity is mathematically compared to salinity using a point slope formula and graphical techniques. Sample solutions of unknown salinity are provided so that the students can sharpen their…

  14. Salinity extrema in the Arabian Sea

    Digital Repository Service at National Institute of Oceanography (India)

    Shenoi, S.S.C.; Shetye, S.R.; Gouveia, A.D.; Michael, G.S.

    salinity of this water due to evaporation in the North Arabian Sea, (2) poleward coastal undercurrent along the west coast of India during the southwest monsoon. The theta-S characteristics of the four salinity extrema are used to put into perspective...

  15. [Acute rhinosinusitis: diagnostics and treatment]. (United States)

    Lazarevich, I A; Kozlov, V S


    Acute rhinosinusitis is a challenging clinical problem due to its high prevalence. The overwhelming majority of the cases of acute rhinosinusitis (ARS) have viral etiology. Clinical manifestations of viral and bacterial rhinosinusitis can be very similar. Similar expert communities have proposed their recommendations on diagnostics and treatment of acute rhinosinusitis in the recent decade. These recommendations are underlain by the principles of evidence-based medicine, take into consideration the result of reliable investigations, and reflect the opinions of leading specialists in otorhinolaryngology, allergology and immunology. The present review contains the analysis of consensus documents and recommendations. The results of ongoing research provide convincing evidence of the effectiveness of intranasal application of corticosteroids in the patients presenting with acute rhinosinusitis. Antibacterial therapy of acute rhinosinusitis is indicated only in the case of severe or complicated clinical course of the disease.

  16. Biochar Mitigates Salinity Stress in Potato

    DEFF Research Database (Denmark)

    Akhtar, S S; Andersen, Mathias Neumann; Liu, Fulai


    capability of biochar. Results indicated that biochar was capable to ameliorate salinity stress by adsorbing Na+. Increasing salinity level resulted in significant reductions of shoot biomass, root length and volume, tuber yield, photosynthetic rate (An), stomatal conductance (gs), midday leaf water...... of salinity through its high sorption ability. From tuber bulking to harvesting, the plants were exposed to three saline irrigations, that is 0, 25 and 50 mm NaCl solutions, respectively, and two levels of biochar (0 % and 5 % W/W) treatments. An adsorption study was also conducted to study the Na+ adsorption...... with the respective non-biochar control. Decreased Na+, Na+/K+ ratio and increased K+ content in xylem with biochar amendment also indicated its ameliorative effects on potato plants in response to salinity stress. The results suggested that incorporation of biochar might be a promising approach for enhancing crop...

  17. Therapeutic Efficacy of Saline and Glucose Saline against Dermally applied Sulphur Mustard Intoxication in Mice

    Directory of Open Access Journals (Sweden)

    K. Sugendran


    Full Text Available A single dose of saline or glucose-saline (5 mg glucose/kg offered similar protection to mice against sulphur mustard intoxication, the extent of survival being 83 per cent as against 33 per cent without treatment. All the animals were protected when the treatment was extended by another two consecutive days in the glucose-saline treated group. Both saline and glucose-saline treatments could ameliorate the haemoconcentration as well as normalise pO/sub 2/ and % oxygen saturation. The protection conferred is attributed to the probable replenishment of fluid loss.

  18. Reconstructing Past Ocean Salinity ((delta)18Owater)

    Energy Technology Data Exchange (ETDEWEB)

    Guilderson, T P; Pak, D K


    Temperature and salinity are two of the key properties of ocean water masses. The distribution of these two independent but related characteristics reflects the interplay of incoming solar radiation (insolation) and the uneven distribution of heat loss and gain by the ocean, with that of precipitation, evaporation, and the freezing and melting of ice. Temperature and salinity to a large extent, determine the density of a parcel of water. Small differences in temperature and salinity can increase or decrease the density of a water parcel, which can lead to convection. Once removed from the surface of the ocean where 'local' changes in temperature and salinity can occur, the water parcel retains its distinct relationship between (potential) temperature and salinity. We can take advantage of this 'conservative' behavior where changes only occur as a result of mixing processes, to track the movement of water in the deep ocean (Figure 1). The distribution of density in the ocean is directly related to horizontal pressure gradients and thus (geostrophic) ocean currents. During the Quaternary when we have had systematic growth and decay of large land based ice sheets, salinity has had to change. A quick scaling argument following that of Broecker and Peng [1982] is: the modern ocean has a mean salinity of 34.7 psu and is on average 3500m deep. During glacial maxima sea level was on the order of {approx}120m lower than present. Simply scaling the loss of freshwater (3-4%) requires an average increase in salinity a similar percentage or to {approx}35.9psu. Because much of the deep ocean is of similar temperature, small changes in salinity have a large impact on density, yielding a potentially different distribution of water masses and control of the density driven (thermohaline) ocean circulation. It is partly for this reason that reconstructions of past salinity are of interest to paleoceanographers.

  19. SMOS sea surface salinity maps of the Arctic Ocean (United States)

    Gabarro, Carolina; Olmedo, Estrella; Turiel, Antonio; Ballabrera-Poy, Joaquim; Martinez, Justino; Portabella, Marcos


    years of SMOS data acquisitions. The second is the modification of the filtering criterion to account for the statistical distributions of SSS at each ocean grid point. This allows retrieving a value of SSS which is less affected by outliers originated from RFI and other effects. We will provide an assessment of the quality of these new SSS products in the Arctic, as well as illustrate the potential of these maps to monitor the main river discharges to the Arctic Ocean. [1] Font, J.; Camps, A.; Borges, A.; Martín-Neira, M.; Boutin, J.; Reul, N.; Kerr, Y.; Hahne, A. & Mecklenburg, S. SMOS: The Challenging Sea Surface Salinity Measurement From Space Proceedings of the IEEE, 2010, 98, 649 -665

  20. Salinity Tolerance and Growth Response of Juvenile Oreochromis mossambicus at Different Salinity Levels

    Institute of Scientific and Technical Information of China (English)

    Khalid Jamil; Muhammad Shoaib; Faisal Ameer; LIN Hong


    Juveniles of Oreochromis mossambicus with initial wet weights of 0.0382±0.0859 g and initial total lengths of 0.735±1.425 cm were tested for their salinity tolerance. The juveniles were subjected to five salinity levels for a period of seventy-five days. These salinity levels correspond to the salinities found along the creek and in estuarine regions. Each set of experiments was conducted at a fifteen day intervals. The weight, length and survival rate were calculated. No mortality was observed at salinity levels 0, 5, 10 and 15, while the juveniles faced slight mortality at 20 in the same environmental conditions, including the diet. There was no significant difference in specific growth rate at all salinity levels. The juveniles of O.mossambicus could survive up to 20 salinity. These results suggest that this species can grow and be exploited commercially in brackish waters, rivers and estuarine regions.

  1. [Ecophysiological adaptability of tropical water organisms to salinity changes]. (United States)

    Chung, K S


    Physiological response of tropical organisms to salinity changes was studied for some marine, estuarine and freshwater fishes (Astyanax bimaculatus, Petenia karussii, Cyprinodon dearborni, and Oreochromis mossambicus), marine and freshwater crustaceans (Penaeus brasiliensis, Penaeus schmitti and Macrobrachium carcinus), and marine bivalves (Perna perna, Crassostrea rhizophorae, and Arca zebra) collected from Northeast Venezuela. They were acclimated for four weeks at various salinities, and (1) placed at high salinities to determine mean lethal salinity, (2) tested by increasing salinity 5@1000 per day to define upper lethal salinity tolerance limit, or (3) observed in a saline gradient tank to determine salinity preference. Acclimation level was the most significant factor. This phenomenon is important for tropical aquatic organisms in shallow waters, where they can adapt to high salinity during the dry season and cannot lose their acclimation level at low salinity during abrupt rain. For saline adaptation of tropical organisms, this behavior will contribute to their proliferation and distribution in fluctuating salinity environments.

  2. Differential Expression of Salinity Resistance Gene on Cotton

    Institute of Scientific and Technical Information of China (English)


    Salinity resistance and differential gene expression associated with salinity in cotton germplasm were studied,because of the large scale area of salinity in China,and its significant negative effects on

  3. Sea-surface salinity: the missing measurement (United States)

    Stocker, Erich F.; Koblinsky, Chester


    Even the youngest child knows that the sea is salty. Yet, routine, global information about the degree of saltiness and the distribution of the salinity is not available. Indeed, the sea surface salinity measurement is a key missing measurement in global change research. Salinity influences circulation and links the ocean to global change and the water-cycle. Space-based remote sensing of important global change ocean parameters such as sea-surface temperature and water-cycle parameters such as precipitation have been available to the research community but a space-based global sensing of salinity has been missing. In July 2002, the National Aeronautical and Space Administration (NASA) announced that the Aquarius mission, focused on the global measurement of sea surface salinity, is one of the missions approved under its ESSP-3 program. Aquarius will begin a risk-reduction phase during 2003. Aquarius will carry a multi-beam 1.4 GHz (L-band) radiometer used for retrieving salinity. It also will carry a 1.2 GHz (L-band) scatterometer used for measuring surface roughness. Aquarius is tentatively scheduled for a 2006 launch into an 8-day Sun-synchronous orbit. Aquarius key science data product will be a monthly, global surface salinity map at 100 km resolution with an accuracy of 0.2 practical salinity units. Aquarius will have a 3 year operational period. Among other things, global salinity data will permit estimates of sea surface density, or buoyancy, that drives the ocean's three-dimensional circulation.

  4. Acute Kidney Failure (United States)

    ... out of balance. Acute kidney failure — also called acute renal failure or acute kidney injury — develops rapidly over ... 2015. Palevsky PM. Definition of acute kidney injury (acute renal failure). Accessed April ...

  5. Acute Pancreatitis and Pregnancy (United States)

    ... Pancreatitis Acute Pancreatitis and Pregnancy Acute Pancreatitis and Pregnancy Timothy Gardner, MD Acute pancreatitis is defined as ... pancreatitis in pregnancy. Reasons for Acute Pancreatitis and Pregnancy While acute pancreatitis is responsible for almost 1 ...

  6. Salinity and survival of Martesia striata (Linn) in Cochin harbour


    Cheriyan, P.V.; Cherian, C.J.


    The effects of salinity variations on the survival of Martesia striata from Cochin harbour are presented. It is observed that at least a few of the animals survive the low saline conditions during monsoon. Laboratory experiments showed the lethal salinity as 6‰ when animals acclimatised in 34‰ were subjected to abrupt changes in salinity. But acclimatisation to 17‰ salinity showed a downward shift in the lethal salinity to 4‰. The present observations indicate that M. striata is euryhaline ar...

  7. A Quantitative Profiling Method of Phytohormones and Other Metabolites Applied to Barley Roots Subjected to Salinity Stress (United States)

    Cao, Da; Lutz, Adrian; Hill, Camilla B.; Callahan, Damien L.; Roessner, Ute


    As integral parts of plant signaling networks, phytohormones are involved in the regulation of plant metabolism and growth under adverse environmental conditions, including salinity. Globally, salinity is one of the most severe abiotic stressors with an estimated 800 million hectares of arable land affected. Roots are the first plant organ to sense salinity in the soil, and are the initial site of sodium (Na+) exposure. However, the quantification of phytohormones in roots is challenging, as they are often present at extremely low levels compared to other plant tissues. To overcome this challenge, we developed a high-throughput LC-MS method to quantify ten endogenous phytohormones and their metabolites of diverse chemical classes in roots of barley. This method was validated in a salinity stress experiment with six barley varieties grown hydroponically with and without salinity. In addition to phytohormones, we quantified 52 polar primary metabolites, including some phytohormone precursors, using established GC-MS and LC-MS methods. Phytohormone and metabolite data were correlated with physiological measurements including biomass, plant size and chlorophyll content. Root and leaf elemental analysis was performed to determine Na+ exclusion and K+ retention ability in the studied barley varieties. We identified distinct phytohormone and metabolite signatures as a response to salinity stress in different barley varieties. Abscisic acid increased in the roots of all varieties under salinity stress, and elevated root salicylic acid levels were associated with an increase in leaf chlorophyll content. Furthermore, the landrace Sahara maintained better growth, had lower Na+ levels and maintained high levels of the salinity stress linked metabolite putrescine as well as the phytohormone metabolite cinnamic acid, which has been shown to increase putrescine concentrations in previous studies. This study highlights the importance of root phytohormones under salinity stress and

  8. Recurrent acute pancreatitis: From the editor

    Institute of Scientific and Technical Information of China (English)

    Pier Alberto Testoni


    @@ This special issue of World Journal of Gastroenterology contains a number of articles focusing on acute recurrent pancreatitis,a clinical entity that still remains a complex diagnostic and therapeutic challenge in clinical practice.

  9. Evaluation of Different Soil Salinity Mapping Using Remote Sensing Techniques in Arid Ecosystems, Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Mohamed Elhag


    Full Text Available Land covers in Saudi Arabia are generally described as salty soils with sand dunes and sand sheets. Waterlogging and higher soil salinity are major challenges to sustaining agricultural practices in Saudi Arabia principally within closed drainage basins. Agricultural practices in Saudi Arabia were flourishing in the last two decades. The newly reclaimed lands were added annually and distributed all over the country. Irrigation techniques are mostly modernized to fulfill water saving strategies. Nevertheless, water resources in Saudi Arabia are under stress and groundwater levels are depleted rapidly due to heavy abstraction that may exceed crop water requirements in most of the cases due to high evaporation rates. The excess use of irrigational water leads to severe soil salinity problems. Applications of remote sensing technique in agricultural practices became widely distinctive and cover multidisciplinary principal interests on both local and regional levels. The most important remote sensing applications in agricultural practices are vegetation indices which are related to vegetation and water especially in an arid environment. Soil salinity mapping in an arid ecosystem using remote sensing data is a demanding task. Several soil salinity indices were implemented and evaluated to detect soil salinity effectively and quantitatively. Thematic maps of soil salinity were satisfactorily produced and assessed.

  10. Tuning of redox regulatory mechanisms, reactive oxygen species and redox homeostasis under salinity stress

    Directory of Open Access Journals (Sweden)

    Hossain eSazzad


    Full Text Available Soil salinity is a crucial environmental constraint which limits biomass production at many sites on a global scale. Saline growth conditions cause osmotic and ionic imbalances, oxidative stress and perturb metabolism, e.g. the photosynthetic electron flow. The plant ability to tolerate salinity is determined by multiple biochemical and physiological mechanisms protecting cell functions, in particular by regulating proper water relations and maintaining ion homeostasis. Redox homeostasis is a fundamental cell property. Its regulation includes control of reactive oxygen species (ROS generation, sensing deviation from and readjustment of the cellular redox state. All these redox related functions have been recognized as decisive factors in salinity acclimation and adaptation. This review focuses on the core response of plants to overcome the challenges of salinity stress through regulation of ROS generation and detoxification systems and to maintain redox homeostasis. Emphasis is given to the role of NADH oxidase (RBOH, alternative oxidase (AOX, the plastid terminal oxidase (PTOX and the malate valve with the malate dehydrogenase isoforms under salt stress. Overwhelming evidence assigns an essential auxiliary function of ROS and redox homeostasis to salinity acclimation of plants.

  11. Approach to acute, recurrent, and chronic pancreatitis. (United States)

    Kinney, Timothy P; Freeman, Martin L


    Pancreatitis can manifest as a one-time episode, recurring attacks, or chronic pain. It is caused by numerous factors ranging from alcohol consumption to gallstones to subtle obstructive causes and occult autoimmune disorders. As a result, determining the etiology and effectively treating the causes and consequences of pancreatitis can be challenging. This article reviews the diagnosis and management of acute, acute recurrent, and chronic pancreatitis, focusing on more challenging scenarios.

  12. Saline water irrigation of quinoa and chickpea

    DEFF Research Database (Denmark)

    Hirich, A.; Jelloul, A.; Choukr-Allah, R.


    A pot experiment was conducted in the south of Morocco to evaluate the response of chickpea and quinoa to different irrigation water salinity treatments (1, 4, 7 and 10 dS m-1 for chickpea and 1, 10, 20 and 30 dS m-1 for quinoa). Increasing salinity affected significantly (P ... and height and caused delay and reduction in seed emergence, quinoa was shown to be more resistant than chickpea. Dry biomass, seed yield, harvest index and crop water productivity were affected significantly (P ... and seed yield for both quinoa and chickpea while increasing salinity resulted in increase - in the case of quinoa - and decrease - in the case of chickpea - in harvest index and crop water productivity. Na+ and Na+/K+ ratio increased with increasing irrigation water salinity, while K+ content decreased...

  13. Treating nahcolite containing formations and saline zones

    Energy Technology Data Exchange (ETDEWEB)

    Vinegar, Harold J


    A method for treating a nahcolite containing subsurface formation includes removing water from a saline zone in or near the formation. The removed water is heated using a steam and electricity cogeneration facility. The heated water is provided to the nahcolite containing formation. A fluid is produced from the nahcolite containing formation. The fluid includes at least some dissolved nahcolite. At least some of the fluid is provided to the saline zone.

  14. Analysis of MicroRNA Expression Profiles in Weaned Pig Skeletal Muscle after Lipopolysaccharide Challenge

    Directory of Open Access Journals (Sweden)

    Jing Zhang


    Full Text Available MicroRNAs (miRNAs constitute a class of non-coding RNAs that play a crucial regulatory role in skeletal muscle development and disease. Several acute inflammation conditions including sepsis and cancer are characterized by a loss of skeletal muscle due primarily to excessive muscle catabolism. As a well-known inducer of acute inflammation, a lipopolysaccharide (LPS challenge can cause serious skeletal muscle wasting. However, knowledge of the role of miRNAs in the course of inflammatory muscle catabolism is still very limited. In this study, RNA extracted from the skeletal muscle of pigs injected with LPS or saline was subjected to small RNA deep sequencing. We identified 304 conserved and 114 novel candidate miRNAs in the pig. Of these, four were significantly increased in the LPS-challenged samples and five were decreased. The expression of five miRNAs (ssc-miR-146a-5p, ssc-miR-221-5p, ssc-miR-148b-3p, ssc-miR-215 and ssc-miR-192 were selected for validation by quantitative polymerase chain reaction (qPCR, which found that ssc-miR-146a-5p and ssc-miR-221-5p were significantly upregulated in LPS-challenged pig skeletal muscle. Moreover, we treated mouse C2C12 myotubes with 1000 ng/mL LPS as an acute inflammation cell model. Expression of TNF-α, IL-6, muscle atrophy F-box (MAFbx and muscle RING finger 1 (MuRF1 mRNA was strongly induced by LPS. Importantly, miR-146a-5p and miR-221-5p also showed markedly increased expression in LPS-treated C2C12 myotubes, suggesting the two miRNAs may be involved in muscle catabolism systems in response to acute inflammation caused by a LPS challenge. To our knowledge, this study is the first to examine miRNA expression profiles in weaned pig skeletal muscle challenged with LPS, and furthers our understanding of miRNA function in the regulation of inflammatory muscle catabolism.


    Directory of Open Access Journals (Sweden)

    Carlos Alberto Brasiliano Campos


    Full Text Available Processing tomato is the most important vegetable crop of the Brazilian agribusiness and few researches have been conducted to evaluate the tolerance of this crop to saline stress. In this study, the effects of five levels of salinity of the irrigation water (1, 2, 3, 4 and 5 dS m-1 and three equivalent proportions of Na:Ca:Mg (1:1:0.5, 4:1:0.5 and 7:1:0.5 were tested on the emergence and vigor of processing tomato, cultivar IPA 6. Seeds were sowed in expanded polystyrene tray (128 cells and each tray received 1 L of water after sowing. The trays were piled and, four days after sowing, they were placed on suspended supports in a greenhouse. Irrigation was accomplished daily from the fifth day after sowing. Only dry weight of shoot and root was affected by sodium proportions, while linear reductions of the speed of emergence, stem length and the dry weight of shoot and root were observed with increasing salinity. Root was more affected than shoot by salinity and relative growth ratioincreased with salinity levels on the 14-21 days after sowing period, indicating that the crop showed a certain increase of salinity tolerance with the time of exposure to salts.

  16. Acute appendicitis in acute leukemia and the potential role of decitabine in the critically ill patient

    Directory of Open Access Journals (Sweden)

    Deepti Warad


    Full Text Available Acute appendicitis in children with acute leukemia is uncommon and often recognized late. Immunocompromised host state coupled with the importance of avoiding treatment delays makes management additionally challenging. Leukemic infiltration of the appendix though rare must also be considered. Although successful conservative management has been reported, surgical intervention is required in most cases. We present our experience with acute appendicitis in children with acute leukemia and a case of complete remission of acute myeloid leukemia with a short course of decitabine. Decitabine may serve as bridging therapy in critically ill patients who are unable to undergo intensive chemotherapy.

  17. [Investigation and canonical correspondence analysis of salinity contents in secondary salinization greenhouse soils in Shanghai suburb]. (United States)

    Tang, Dong; Mao, Liang; Zhi, Yue-e; Zhang, Jin-Zhong; Zhou, Pei; Chai, Xiao-Tong


    The salinity characteristics of greenhouse soils with cropping obstacles in Shanghai suburb were investigated and analyzed. The salinity contents of the salinization greenhouse soils showed a trend of first increasing and then decreasing with the increasing cropping duration. The salinized soils mainly included slightly salted, mildly salted and salted soils, which accounted for 17.39%, 56.52% and 13.04%, respectively. Among them, the degree of salinity in greenhouse soil planted with asparagus in Chongming County was the highest. Among the salt ions in greenhouse soils, the cations were mainly Ca2+ and Na+, while the anions were mainly NO3- and SO4(2-). The degree of salinity was mainly influenced by fertilization mode, cropping duration, crop type and management level, which led to the great variation in the salinity contents and salt ions. Canonical correspondence analysis found that the contents of Ca2+, Mg2+ and NO3- in greenhouse soils were greatly affected by cropping duration, and the degree of salinity would be enhanced and attenuated with long-term application of single fertilizer and mixed application of chemical fertilizer and organic manure, respectively. The greenhouse soils in Shanghai suburb could be classified as four patterns influenced by the relationship between salinity ions and samples, and the most soils were influenced by Ca2+, Mg2+, NO3- and Cl-, which required to be primarily controlled.

  18. Yield and yield components of wheat as affected by salinity and inoculation with Azospirillum strains from saline or non-saline soil

    Directory of Open Access Journals (Sweden)

    Somayeh Haji Nia


    Full Text Available In many arid and semi-arid areas of the world where sustainability of agriculture is limited by salinity, use of biological potential may be a key component of sustainable plant production. A greenhouse experiment was used to test the effectiveness of inoculation with Azospirillum strains isolated from saline or non-saline soil in alleviating the salinity stress in wheat plants grown with irrigation water with different electrical conductivities (ECw of 0.7, 4, 8 and 12 dS m−1. Inoculation with the two isolates increased salinity tolerance of wheat plants; the saline-adapted isolate significantly increased shoot dry weight and grain yield under severe water salinity. The component of grain yield most affected by inoculation was grains per plant. Plants inoculated with saline-adapted Azospirillum strains had higher N concentrations at all water salinity levels.

  19. Challenges in comparing the acute cognitive outcomes of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) vs. electroconvulsive therapy (ECT) in major depression: A systematic review. (United States)

    Kedzior, Karina Karolina; Schuchinsky, Maria; Gerkensmeier, Imke; Loo, Colleen


    The present study aimed to systematically compare the cognitive outcomes of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) and electroconvulsive therapy (ECT) in head-to-head studies with major depression (MDD) patients. A systematic literature search identified six studies with 219 MDD patients that were too heterogeneous to reliably detect meaningful differences in acute cognitive outcomes after ECT vs. HF-rTMS. Cognitive effects of brain stimulation vary depending on the timeframe and methods of assessment, stimulation parameters, and maintenance treatment. Thus, acute and longer-term differences in cognitive outcomes both need to be investigated at precisely defined timeframes and with similar instruments assessing comparable functions.

  20. Progressive acclimation alters interaction between salinity and temperature in experimental Daphnia populations. (United States)

    Loureiro, Cláudia; Cuco, Ana P; Claro, Maria Teresa; Santos, Joana I; Pedrosa, M Arminda; Gonçalves, Fernando; Castro, Bruno B


    Environmental stressors rarely act in isolation, giving rise to interacting environmental change scenarios. However, the impacts of such interactions on natural populations must consider the ability of organisms to adapt to environmental changes. The phenotypic adaptability of a Daphnia galeata clone to temperature rise and salinisation was investigated in this study, by evaluating its halotolerance at two different temperatures, along a short multigenerational acclimation scenario. Daphniids were acclimated to different temperatures (20°C and 25°C) and salinities (0gL(-1) and 1gL(-1), using NaCl as a proxy) in a fully crossed design. The objective was to understand whether acclimation to environmental stress (combinations of temperature and salinity) influenced the response to the latter exposure to these stressors. We hypothesize that acclimation to different temperature×salinity regimes should elicit an acclimation response of daphniids to saline stress or its interaction with temperature. Acute (survival time) and chronic (juvenile growth) halotolerance measures were obtained at discrete timings along the acclimation period (generations F1, F3 and F9). Overall, exposure temperature was the main determinant of the acute and chronic toxicity of NaCl: daphniid sensitivity (measured as the decrease of survival time or juvenile growth) was consistently higher at the highest temperature, irrespective of background conditions. However, this temperature-dependent effect was nullified after nine generations, but only when animals had been acclimated to both stressors (high salinity and high temperature). Such complex interaction scenarios should be taken in consideration in risk assessment practices.

  1. Salinity Measurements During the Gulf Stream Experiment (United States)

    LeVine, D. M.; Koblinsky, C.; Howden, S.; Goodberlet, M.


    The salinity of the open ocean is important for understanding ocean circulation, for understanding energy exchange with the atmosphere and for improving models to predict weather and climate. Passive microwave sensors at L-band (1.4 GHz) operating from aircraft have demonstrated that salinity can be measured with sufficient accuracy (1 psu) to be scientifically meaningful in coastal waters. However, measuring salinity in the open ocean presents unresolved issues largely because of the much greater accuracy (approx. 0.1 psu) required to be scientifically viable. In the summer of 1999 a series of measurements called, The Gulf Stream Experiment, were conducted as part of research at the Goddard Space Flight Center to test the potential for passive microwave remote sensing of salinity in the open ocean. The measurements consisted of a compliment of airborne microwave instruments (radiometers and scatterometer) and ships and drifters for surface truth. The study area was a 200 km by 100 km rectangle about 250 km east of Delaware Bay between the continental shelf waters and north wall of the Gulf Stream. The primary passive instruments were the ESTAR radiometer (L-band, H-pol) and the SLFMR radiometer (L-band, V-pol). In addition, the compliment of instruments on the aircraft included a C-band radiometer (ACMR), an ocean wave scatterometer (ROWS) and an infrared radiometer. A GPS backscatter experiment was also part of the package. These instruments were mounted on the NASA P-3 Orion aircraft. Surface salinity measurements were provided by the RN Cape Henlopen and MN Oleander (thermosalinographs) plus salinity and temperature sensors on three surface drifters deployed from the RN Cape Henopen. The primary experiment period was August 26-September 2, 1999. During this period the salinity field within the study area consisted of a gradient on the order of 2-3 psu in the vicinity of the shelf break and a warm core ring with a gradient of 1-2 psu. Detailed maps were made

  2. Treatment of acute viral bronchiolitis. (United States)

    Eber, Ernst


    Acute viral bronchiolitis represents the most common lower respiratory tract infection in infants and young children and is associated with substantial morbidity and mortality. Respiratory syncytial virus is the most frequently identified virus, but many other viruses may also cause acute bronchiolitis. There is no common definition of acute viral bronchiolitis used internationally, and this may explain part of the confusion in the literature. Most children with bronchiolitis have a self limiting mild disease and can be safely managed at home with careful attention to feeding and respiratory status. Criteria for referral and admission vary between hospitals as do clinical practice in the management of acute viral bronchiolitis, and there is confusion and lack of evidence over the best treatment for this condition. Supportive care, including administration of oxygen and fluids, is the cornerstone of current treatment. The majority of infants and children with bronchiolitis do not require specific measures. Bronchodilators should not be routinely used in the management of acute viral bronchiolitis, but may be effective in some patients. Most of the commonly used management modalities have not been shown to have a clear beneficial effect on the course of the disease. For example, inhaled and systemic corticosteroids, leukotriene receptor antagonists, immunoglobulins and monoclonal antibodies, antibiotics, antiviral therapy, and chest physiotherapy should not be used routinely in the management of bronchiolitis. The potential effect of hypertonic saline on the course of the acute disease is promising, but further studies are required. In critically ill children with bronchiolitis, today there is little justification for the use of surfactant and heliox. Nasal continuous positive airway pressure may be beneficial in children with severe bronchiolitis but a large trial is needed to determine its value. Finally, very little is known on the effect of the various

  3. Oceanographic profile Temperature, Salinity and other measurements collected using bottle and high resolution CTD from the CHALLENGER (UK cruises 1962 to present) and other platforms in the Coastal N Atlantic, North Atlantic and other locations from 24 December 1988 to 16 August 2000 (NODC Accession 0000419) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD, bottle, and other data were collected in the coastal North Atlantic and other locations from the Challenger and other platforms from 24 December 1988 to 16...

  4. Dwarf cashew growth irrigated with saline waters

    Directory of Open Access Journals (Sweden)

    Hugo Orlando Carvallo Guerra


    Full Text Available The cashew production is one of the most important agricultural activities from the social-economical viewpoint for the North East of Brazil; besides to produce a great deal of hand labor, it is very important as an exporting commodity. The inadequate use of irrigation in the semi arid regions of the North East of Brazil has induced soil salinization and consequently problems for the irrigated agriculture. In spite of this, few works have been conducted to study the effect of saline stress on the growth and development of the cashew. Because of the lack of information for this crop, an experiment was conducted to study the effect of salinity stress on the phytomass production and nutrient accumulation on the different organs of the precocious dwarf cashew (Anacardium occidentale L. clone CCP76. The study was conducted under controlled conditions using as statistical scheme a randomized block design factorial with six replicates. Five salinity treatments were considered for the irrigation water (electrical conductivities of 0.8, 1.6, 2.4, 3.2 and 4.0 dS m-1 at 25oC. The increasing in salinity of the irrigation water reduced the phytomass at different organs of the studied plant. The nitrogen, phosphorus, potassium, chloride and sodium in the plant varied with the salinity of the irrigation water according with the part of the plant analyzed; in some parts increased, in others decreased, in others increased initially and decreased afterwards, and finally, in other part of the plant the salinity of the irrigation water did not affect the nutrient concentration.

  5. Preparation and swelling behavior of polyvinyl alcohol physiological saline gel

    Institute of Scientific and Technical Information of China (English)


    Polyvinyl alcohol(PVA) physiological saline gel was prepared using physiological saline solution of the polymer by freezing and thawing method. The influences of the concentration of PVA, freezing and thawing cycle times and solvent swelling media on the swelling properties of PVA saline gel were investigated. The result show that the electrolytical ions have great effect on the swelling behavior of PVA saline gel. The equilibrium swelling ratio of PVA saline gel in aqueous swelling media is larger than that in saline swelling media. Also, the equilibrium swelling ratios of PVA saline gel in aqueous and in saline media decrease with the increase of gel concentration and the increase of freezing and thawing cycle times. The decreasing speed of equilibrium swelling ratio with the increase of freezing and thawing cycle times of PVA gel in distilled water is faster than that in physiological saline. The swelling kinetic equation can sufficiently describe the swelling behavior of PVA physiological saline gel.

  6. A new method to retrieve salinity profiles from sea surface salinity observed by SMOS satellite

    Institute of Scientific and Technical Information of China (English)

    YANG Tingting; CHEN Zhongbiao; HE Yijun


    This paper proposes a new method to retrieve salinity profiles from the sea surface salinity (SSS) observed by the Soil Moisture and Ocean Salinity (SMOS) satellite. The main vertical patterns of the salinity profiles are firstly extracted from the salinity profiles measured by Argo using the empirical orthogonal function. To determine the time coefficients for each vertical pattern, two statistical models are developed. In the linear model, a transfer function is proposed to relate the SSS observed by SMOS (SMOS_SSS) with that measured by Argo, and then a linear relationship between the SMOS_SSS and the time coefficient is established. In the nonlinear model, the neural network is utilized to estimate the time coefficients from SMOS_SSS, months and positions of the salinity profiles. The two models are validated by comparing the salinity profiles retrieved from SMOS with those measured by Argo and the climatological salinities. The root-mean-square error (RMSE) of the linear and nonlinear model are 0.08–0.16 and 0.08–0.14 for the upper 400 m, which are 0.01–0.07 and 0.01–0.09 smaller than the RMSE of climatology. The error sources of the method are also discussed.

  7. Diagnosis of acute neuropathies

    DEFF Research Database (Denmark)

    Crone, Clarissa; Krarup, Christian


    Acute and subacute polyneuropathies present diagnostic challenges since many require prompt initiation of treatment in order to limit axonal degeneration and since an exact and detailed diagnosis is a prerequisite for making the correct choice of treatment. It is for instance of utmost importance...... to recognize whether the underlying pathological changes are due to demyelination or to axonal degeneration and electrodiagnostic tests can thus in most cases contribute considerably to the securing of an exact diagnosis. The specific and characteristic electrophysiological findings in the different types...

  8. Options for salinity mitigation in the Murray-Darling Basin


    Schrobback, Peggy; Adamson, David; Quiggin, John


    The Murray-Darling Basin faces increasing pressure on water quantity and quality. In 2006-07, salt interception schemes implemented as part of the Murray–Darling Basin Salinity Management strategy removed over 470,000 tonnes of salt from the water supply, reducing the salinity of water flowing to Adelaide by about 200 EC units. However, the costs of salinity mitigation schemes are increasing. With possible continuing declines in average inflows, costs of salinity and salinity mitigation are...

  9. Genetic diversity analysis of salinity related germplasm in cotton


    Lina Zhang; Wuwei Ye; Junjuan Wang; Baoxiang Fan; Delong Wang


    In order to study the genetic variation of salinity related cotton germplasm, 47 upland cotton accessions including 23 salinity tolerant materials and 24 salinity sensitive materials were explored using 88 simple sequence repeat (SSR) markers. We detected a total of 338 alleles at 88 SSR loci with an average of 3.841 alleles per locus, 333 of these alleles were detected in salinity tolerant germplasm and 312 alleles in salinity sensitive germplasm. Mean polymorphism information content (PIC),...

  10. Growth of sugar cane varieties under salinity

    Directory of Open Access Journals (Sweden)

    Welson Lima Simões


    Full Text Available ABSTRACT Large salty areas in the Brazilian semi-arid region have limited farming in Northeastern Brazil. One example is the sugar cane cultivation, which reinforces the need of selecting varieties that are more tolerant to salinity. The objective of this study was to evaluate the effect of salinity on growth of ten varieties of sugar cane. The experiment was conducted in a greenhouse, set in the experimental field of Embrapa Semiárido, in Petrolina, Pernambuco State. The experimental design was randomized blocks arranged in a 6 X 10 factorial arrangement, comprised of six levels of salinity (0, 1.0, 2.0, 4.0, 6.0 and 8.0 dS m-1 and ten sugar cane varieties (VAT 90212; RB 72454; RB 867515; Q 124; RB 961003; RB 957508; SP791011; RB 835089; RB 92579 and SP 943206. Salt levels of irrigation water were obtained by adding NaCl, CaCl2.2H2O and MgSO4.7H2O to achieve an equivalent ratio among Na:Ca:Mg of 7:2:1. Sixty days later, plant height, stem diameter (base, number of leaves, stalks and sprouts, leaf area and fresh and dry mass of the aerial part and roots were all measured. The varieties of sugar cane showed similar responses for growth reduction as soil salinity increases, being considered moderately sensitive to salinity.

  11. Lessons from crop plants struggling with salinity. (United States)

    Cabot, Catalina; Sibole, John V; Barceló, Juan; Poschenrieder, Charlotte


    Salinity is a persistent problem, causing important losses in irrigated agriculture. According to global climate change prediction models, salinity is expected to expand in the near future. Although intensive studies have been conducted on the mechanisms by which plants cope with saline conditions, the multi-component nature of salt stress tolerance has rendered most plant breeding efforts to improve the plant's response to salinity unsuccessful. This occurs despite the extensive genetic diversity shown by higher plants for salt tolerance and the similar mechanisms found in salt-sensitive and salt-tolerant genotypes in response to the presence of excess of salts in the growth media. On the other hand, there is an urge to increase crop yield to the maximum to cope with the growing world population demands for food and fuel. Here, we examine some major elements and signaling mechanisms involved in the plant's response to salinity following the pathway of salt-footprints from the soil environment to leaf. Some of the possible contrasting determinants for a better-balanced resource allocation between salt tolerance and plant growth and yield are considered.

  12. Salinity transfer in bounded double diffusive convection

    CERN Document Server

    Yang, Yantao; Ostilla-Mónico, Rodolfo; Sun, Chao; Verzicco, Roberto; Grossmann, Siegfried; Lohse, Detlef


    The double diffusive convection between two parallel plates is numerically studied for a series of parameters. The flow is driven by the salinity difference and stabilized by the thermal field. Our simulations are directly compared to experiments by Hage and Tilgner (\\emph{Phys. Fluids} 22, 076603 (2010)) for several sets of parameters and reasonable agreement is found. This in particular holds for the salinity flux and its dependence on the salinity Rayleigh number. Salt fingers are present in all simulations and extend through the entire height. The thermal Rayleigh number seems to have minor influence on salinity flux but affects the Reynolds number and the morphology of the flow. Next to the numerical calculation, we apply the Grossmann-Lohse theory for Rayleigh-B\\'{e}nard flow to the current problem without introducing any new coefficients. The theory successfully predicts the salinity flux both with respect to the scaling and even with respect to the absolute value for the numerical and experimental res...

  13. Biomarker-based salinity reconstruction immediately prior to the Messinian Salinity Crisis (Sorbas Basin, Spain) (United States)

    Mayser, Jan Peter; Martins, Cesar; Flecker, Rachel; Pancost, Rich D.


    The salinity crisis which occurred in the Mediterranean at the end of the Miocene (5.97 to 5.33 Ma) was a time of large-scale environmental change and thick evaporite deposits formed both in the deep basins and on the surrounding margins. Late Miocene successions in the Sorbas Basin, south east Spain preserve sediments that were deposited immediately prior to the Messinian Salinity Crisis (MSC) and during the initial phase of gypsum precipitation (Sierro et al., 2001). Salinity changes are indicated by evaporite formation and fluctuations in faunal assemblages, but these provide threshold measurements only e.g. gypsum forms at a salinity of 130 psu. By analysing the lipid biomarker composition by GC and HPLC-MS after Soxhlet extraction of pre-MSC sediments we aim to reconstruct granular changes in salinity leading up to initial gypsum precipitation. The pre-MSC sediments comprise regular alternations of marine marls and terrigenous clays with interspersed diatomites. This lithological cyclicity is climatically forced by orbitally-driven changes in insolation (Krijgsman et al., 1999) such that specific lithologies are thought to accumulate during precession minima (homogeneous marls) and maxima (laminated marls). By targeting these lithologies for salinity reconstruction we can evaluate the orbital control on quantified environmental change. The reconstruction of the salinity is predominantly based on the ACE proxy introduced by Turich and Freeman (2011). The GDGT-based proxy can show differences over a wide range of salinity, because Archaea can survive over a much larger salinity range than haptophyte algae or other plankton and can therefore also record the salinity signal over a wider range. This makes it suitable for the broad salinity ranges leading up to the MSC e.g. ~35 to 130 psu. Turich et al. (2011) already have published 10 low resolution salinity values for pre-MSC sediments from Torrente Vaccarizzo and Serra Pirciata on Sicily. Our high resolution

  14. Salinity-induced regulation of the myo-inositol biosynthesis pathway in tilapia gill epithelium. (United States)

    Sacchi, Romina; Li, Johnathon; Villarreal, Fernando; Gardell, Alison M; Kültz, Dietmar


    The myo-inositol biosynthesis (MIB) pathway converts glucose-6-phosphate to the compatible osmolyte myo-inositol that protects cells from osmotic stress. Using proteomics, the enzymes that constitute the MIB pathway, myo-inositol phosphate synthase (MIPS) and inositol monophosphatase 1 (IMPA1), are identified in tilapia (Oreochromis mossambicus) gill epithelium. Targeted, quantitative, label-free proteomics reveals that they are both upregulated during salinity stress. Upregulation is stronger when fish are exposed to severe (34 ppt acute and 90 ppt gradual) relative to moderate (70 ppt gradual) salinity stress. IMPA1 always responds more strongly than MIPS, suggesting that MIPS is more stable during salinity stress. MIPS is N-terminally acetylated and the corresponding peptide increases proportionally to MIPS protein, while non-acetylated N-terminal peptide is not detectable, indicating that MIPS acetylation is constitutive and may serve to stabilize the protein. Hyperosmotic induction of MIPS and IMPA1 is confirmed using western blot and real-time qPCR and is much higher at the mRNA than at the protein level. Two distinct MIPS mRNA variants are expressed in the gill, but one is more strongly regulated by salinity than the other. A single MIPS gene is encoded in the tilapia genome whereas the zebrafish genome lacks MIPS entirely. The genome of euryhaline tilapia contains four IMPA genes, two of which are expressed, but only one is salinity regulated in gill epithelium. The genome of stenohaline zebrafish contains a single IMPA gene. We conclude that the MIB pathway represents a major salinity stress coping mechanism that is regulated at multiple levels in euryhaline fish but absent in stenohaline zebrafish.

  15. Females have greater left ventricular twist mechanics than males during acute reductions to preload. (United States)

    Williams, Alexandra M; Shave, Rob E; Stembridge, Mike; Eves, Neil D


    Compared to males, females have smaller left ventricular (LV) dimensions and volumes, higher ejection fractions (EF), and higher LV longitudinal and circumferential strain. LV twist mechanics determine ventricular function and are preload-dependent. Therefore, the sex differences in LV structure and myocardial function may result in different mechanics when preload is altered. This study investigated sex differences in LV mechanics during acute challenges to preload. With the use of conventional and speckle-tracking echocardiography, LV structure and function were assessed in 20 males (24 ± 6.2 yr) and 20 females (23 ± 3.1 yr) at baseline and during progressive levels of lower body negative pressure (LBNP). Fourteen participants (8 males, 6 females) were also assessed following a rapid infusion of saline. LV end-diastolic volume, end-systolic volume, stroke volume (SV), and EF were reduced in both groups during LBNP (P mechanics following saline infusion. Females have larger LV twist and a faster untwisting velocity than males during large reductions to preload, supporting that females have a greater reliance on LV twist mechanics to maintain SV during severe reductions to preload.

  16. The influence of salinity on toxicological effects of arsenic in digestive gland of clam Ruditapes philippinarum using metabolomics

    Institute of Scientific and Technical Information of China (English)

    JI Chenglong; WU Huifeng; LIU Xiaoli; ZHAO Jianmin; YU Junbao; YIN Xiuli


    Ruditapes philippinarum,a clam that thrives in intertidal zones of various salinities,is a useful biomonitor to marine contaminants.We investigated the influence of dilution to 75% and 50% of normal seawater salinity (31.1) on the responses of the digestive gland of R.philippinarum to arsenic exposure (20 μg/L),using nuclear magnetic resonance (NMR)-based metabolomics.After acute arsenic exposure for 48 h,salinity-dependent differential metabolic responses were detected.In normal seawater,arsenic exposure increased the concentrations of branched-chain amino acids,and of threonine,proline,phosphocholine and adenosine,and it decreased the levels of alanine,hypotaurine,glucose,glycogen and ATP in the digestive glands.Differential changes in metabolic biomarkers observed at lower salinity (~23.3)included elevation of succinate,taurine and ATP,and depletion of branched-chain amino acids,threonine and glutamine.Unique effects of arsenic at the lowest salinity (~15.6) included down-regulation of glutamate,succinate and ADP,and up-regulation of phosphocholine.We conclude that salinity influences the metabolic responses of this clam to arsenic.

  17. Spectral reflectance characteristics of soils in northeastern Brazil as influenced by salinity levels. (United States)

    Pessoa, Luiz Guilherme Medeiros; Freire, Maria Betânia Galvão Dos Santos; Wilcox, Bradford Paul; Green, Colleen Heather Machado; De Araújo, Rômulo José Tolêdo; De Araújo Filho, José Coelho


    In northeastern Brazil, large swaths of once-productive soils have been severely degraded by soil salinization, but the true extent of the damage has not been assessed. Emerging remote sensing technology based on hyperspectral analysis offers one possibility for large-scale assessment, but it has been unclear to what extent the spectral properties of soils are related to salinity characteristics. The purpose of this study was to characterize the spectral properties of degraded (saline) and non-degraded agricultural soils in northeastern Brazil and determine the extent to which these properties correspond to soil salinity. We took soil samples from 78 locations within a 45,000-km(2) site in Pernambuco State. We used cluster analysis to group the soil samples on the basis of similarities in salinity and sodicity levels, and then obtained spectral data for each group. The physical properties analysis indicated a predominance of the coarse sand fraction in almost all the soil groups, and total porosity was similar for all the groups. The chemical analysis revealed different levels of degradation among the groups, ranging from non-degraded to strongly degraded conditions, as defined by the degree of salinity and sodicity. The soil properties showing the highest correlation with spectral reflectance were the exchangeable sodium percentage followed by fine sand. Differences in the reflectance curves for the various soil groups were relatively small and were not significant. These results suggest that, where soil crusts are not present, significant challenges remain for using hyperspectral remote sensing to assess soil salinity in northeastern Brazil.

  18. Electromagnetic simulations for salinity index error estimation (United States)

    Wilczek, Andrzej; Szypłowska, Agnieszka; Kafarski, Marcin; Nakonieczna, Anna; Skierucha, Wojciech


    Soil salinity index (SI) is a measure of salt concentration in soil water. The salinity index is calculated as a partial derivative of the soil bulk electrical conductivity (EC) with respect to the bulk dielectric permittivity (DP). The paper focused on the impact of different sensitivity zones for measured both EC and DP on the salinity index determination accuracy. For this purpose, a set of finite difference time domain (FDTD) simulations was prepared. The simulations were carried out on the model of a reflectometric probe consisting of three parallel rods inserted into a modelled material of simulated DP and EC. The combinations of stratified distributions of DP and EC were tested. An experimental verification of the simulation results on selected cases was performed. The results showed that the electromagnetic simulations can provide useful data to improve accuracy of the determination of soil SI.

  19. Hemodynamic effects of acute digitalization several months after acute myocardial infarction. (United States)

    Ressl, J; Jandová, R; Jebavý, P; Kasalický, J; Widimský, J


    Left ventricular function was investigated at rest and during exercise by heart catheterization in 15 patients 3-5 months after acute myocardial infarction. The effect of 1 mg digoxin i.v. in ten patients was correlated to placebo (saline solution) in five patients. A significant decrease of the left ventricular enddiastolic pressure, increase of left ventricular systolic ejection fraction and a shift of the left ventricular function curve to left upwards was found after digoxin with no changes in the placebo group. This beneficial effect of acute digitalization in patients convalescing from uncomplicated myocardial infarction without clinical signs of manifest heart failure could have therapeutic implication.

  20. Wave Induced Saline Intrusion in Sea Outfalls

    DEFF Research Database (Denmark)

    Larsen, Torben; Burrows, Richard


    Experimental and numerical studies have shown that the influence of wave increases the tendency of saline intrusion in multi-riser sea outfalls. The flow field in the diffusor under such unsteady and inhomogeneous circumstances is in general very complex, but when sufficient wave energy is dissip......Experimental and numerical studies have shown that the influence of wave increases the tendency of saline intrusion in multi-riser sea outfalls. The flow field in the diffusor under such unsteady and inhomogeneous circumstances is in general very complex, but when sufficient wave energy...

  1. Adaptation of teleosts to very high salinity

    DEFF Research Database (Denmark)

    Laverty, Gary; Skadhauge, Erik


    A number of species of euryhaline teleosts have the remarkable ability to adapt and survive in environments of extreme salinity, up to two or even three times the osmolality of seawater. This review looks at some of the literature describing the adaptive changes that occur, primarily with intesti......A number of species of euryhaline teleosts have the remarkable ability to adapt and survive in environments of extreme salinity, up to two or even three times the osmolality of seawater. This review looks at some of the literature describing the adaptive changes that occur, primarily...


    Muraeva, O A; Maltseva, A L; Mikhailova, N A; Granovitch, A I


    Salinity is one of the most important abiotic environmental factors affecting marine animals. If salinity deviate from optimum, adaptive mechanisms switch on to maintain organism's physiological activity. In this study, the reaction of the snails Littorina saxatilis from natural habitats and in response to experimental salinity decreasing was analyzed on proteomic level. The isolation of all snails inside their shells and gradually declining mortality was observed under acute experimental salinity decrease (down to 10 per hundred). Proteomic changes were evaluated in the surviving experimental mollusks compared to control individual using differential 2D gel-electrophoresis (DIGE) and subsequent LC-MS/MS-identification of proteins. Approximately 10% of analyzed proteins underwent up- or down regulation during the experiment. Proteins of folding, antioxidant response, intercellular matrix, cell adhesion, cell signaling and metabolic enzymes were identified among them. Proteome changes observed in experimental hypoosmotic stress partially reproduced in the proteomes of mollusks that live in conditions of natural freshening (estuaries). Possible mechanisms involved in the adaptation process of L. saxatilis individuals to hypo-osmotic stress are discussed.

  3. Batteries for Efficient Energy Extraction from a Water Salinity Difference

    KAUST Repository

    La Mantia, Fabio


    The salinity difference between seawater and river water is a renewable source of enormous entropic energy, but extracting it efficiently as a form of useful energy remains a challenge. Here we demonstrate a device called "mixing entropy battery", which can extract and store it as useful electrochemical energy. The battery, containing a Na2-xMn 5O10 nanorod electrode, was shown to extract energy from real seawater and river water and can be applied to a variety of salt waters. We demonstrated energy extraction efficiencies of up to 74%. Considering the flow rate of river water into oceans as the limiting factor, the renewable energy production could potentially reach 2 TW, or ∼13% of the current world energy consumption. The mixing entropy battery is simple to fabricate and could contribute significantly to renewable energy in the future. © 2011 American Chemical Society.

  4. Batteries for efficient energy extraction from a water salinity difference. (United States)

    La Mantia, Fabio; Pasta, Mauro; Deshazer, Heather D; Logan, Bruce E; Cui, Yi


    The salinity difference between seawater and river water is a renewable source of enormous entropic energy, but extracting it efficiently as a form of useful energy remains a challenge. Here we demonstrate a device called "mixing entropy battery", which can extract and store it as useful electrochemical energy. The battery, containing a Na(2-x)Mn(5)O(10) nanorod electrode, was shown to extract energy from real seawater and river water and can be applied to a variety of salt waters. We demonstrated energy extraction efficiencies of up to 74%. Considering the flow rate of river water into oceans as the limiting factor, the renewable energy production could potentially reach 2 TW, or ∼13% of the current world energy consumption. The mixing entropy battery is simple to fabricate and could contribute significantly to renewable energy in the future.

  5. [Pregnancy and acute ischemic stroke]. (United States)

    Bereczki, Dániel


    Pregnancy-related ischemic strokes play an important role in both maternal and fetal morbidity and mortality. Changes in hemostaseology and hemodynamics as well as risk factors related to or independent from pregnancy contribute to the increased stroke-risk during gestation and the puerperium. Potential teratogenic effects make diagnostics, acute therapy and prevention challenging. Because randomized, controlled trials are not available, a multicenter registry of patients with gestational stroke would be desirable. Until definite guidelines emerge, management of acute ischemic stroke during pregnancy remains individual, involving experts and weighing the risks and benefits.

  6. Effects of inhaled L-arginine administration in a murine model of acute asthma.

    Directory of Open Access Journals (Sweden)

    Zeynep Arikan-Ayyildiz


    Full Text Available Increased arginase activity in the airways decreases L-arginine and causes deficiency of bronchodilating and anti-inflammatory nitric oxide (NO in asthma. As, it is suggested that L-arginine may have therapeutic potential in asthma treatment, we aimed to investigate the effects of inhaled L-arginine on oxygen saturation (SaO₂ and airway histology in a murine model of acute asthma. Twenty eight BALB/c mice were divided into four groups; I, II, III and IV (control. All groups except the control were sensitized and challenged with ovalbumin. After establishement of acute asthma attack by metacholine administration, the mice were treated with inhaled L-arginine (Group I, saline (Group II and budesonide (Group III, respectively. SaO₂was measured by pulse oximeter just before and 5 min after methacholine. A third measurement of SaO₂was also obtained 15 min after drug administration in these study groups. Inflammation in the lung tissues of the sacrificed animals were scored to determine the effects of the study drugs. The number of eosinophils in bronchoalveolar lavage (BAL was determined. The results indicated that inflammatory scores significantly improved in groups receiving study drugs when compared with placebo and L-arginine was similar in decreasing scores when compared with budesonide. SaO₂had a tendency to increase after L-arginine administration after acute asthma attack and this increase was statistically significant (p=0.043. Eosinophilia in BAL significantly reduced in group receiving L-arginine when compared with placebo (p<0.05. Thus in this study we demonstrated that L-arginine improved SaO₂and inflammatory scores in an acute model of asthma.

  7. Challenged Pragmatism

    DEFF Research Database (Denmark)

    Christoffersen, Lisbet; Vinding, Niels Valdemar


    of religious faith have made religious claims and thereby challenged a secular understanding of the Danish labour market. This raises the question of the extent to which the religion of the individual can be accepted in the general public sphere. At the same time, religious ethos organisations have argued...

  8. Biomass production on saline-alkaline soils

    Energy Technology Data Exchange (ETDEWEB)

    Chaturvedi, A.N.


    In a trial of twelve tree species (both nitrogen fixing and non-fixing) for fuel plantations on saline-alkaline soil derived from Gangetic alluvium silty clay, Leucaena leucocephala failed completely after showing rapid growth for six months. Results for other species at age two showed that Prosopis juliflora had the best productivity.

  9. About uncertainties in practical salinity calculations

    Directory of Open Access Journals (Sweden)

    M. Le Menn


    Full Text Available Salinity is a quantity computed, in the actual state of the art, from conductivity ratio measurements, knowing temperature and pressure at the time of the measurement and using the Practical Salinity Scale algorithm of 1978 (PSS-78 which gives practical salinity values S. The uncertainty expected on PSS-78 values is ±0.002, but nothing has ever been detailed about the method to work out this uncertainty, and the sources of errors to include in this calculation. Following a guide edited by the Bureau International des Poids et Mesures (BIPM, this paper assess, by two independent methods, the uncertainties of salinity values obtained from a laboratory salinometer and Conductivity-Temperature-Depth (CTD measurements after laboratory calibration of a conductivity cell. The results show that the part due to the PSS-78 relations fits is sometimes as much significant as the instruments one's. This is particularly the case with CTD measurements where correlations between the variables contribute to decrease largely the uncertainty on S, even when the expanded uncertainties on conductivity cells calibrations are largely up of 0.002 mS/cm. The relations given in this publication, and obtained with the normalized GUM method, allow a real analysis of the uncertainties sources and they can be used in a more general way, with instruments having different specifications.

  10. Investigations in Marine Chemistry: Salinity I. (United States)

    Schlenker, Richard M.

    Presented is a unit designed for curriculum infusion and which relies on the hands-on discovery method as an instructive device. The student is introduced to the theory of a functioning salt water conductivity meter. The student explores the resistance of salt water as salinity increases and he treats the data which he has gathered,…

  11. Evaluation of lettuce genotypes for salinity tolerance (United States)

    Lettuce is one of the most commonly used salad vegetables and considered to be a relatively salt sensitive crop. Salinity is a major constraint to crop production in all important lettuce districts of the U.S., and the water quality problem is exacerbated by the climate change. In order to identify ...


    Healthy seagrass beds were once found throughout the shallow areas of Narragansett Bay, R.I. but have disappeared due to infilling, pollution and disease. In Greenwich Bay, a highly developed embayment within Narragansett Bay, Ruppia maritima has colonized an area on the northern shore once dominated by Zostera marina. This area is sandy, which may allow groundwater seepage. Ruppia is extremely salinity tolerant, and may also be more nutrient tolerant than Zostera. A six week microcosm experiment at two salinity (20 and 30 ppt) and 4 nutrient (0, 5, 10, and 30 µM inorganic N) levels to test their relative tolerance was conducted in 2014. Treatments were renewed daily to simulate tidal flushing and the exposure water was dosed with 15N for the first week of the experiment. At the end of the experiment, the plants were weighed and measured, and dried for later isotopic analysis. In the first experiment, Ruppia had significant structural responses to both nutrients and salinity; there was a slight decline in root weight and a decrease in the total number of shoots with increasing nutrients. Average Ruppia blade length decreased with increasing nutrients and this decrease was more evident at 30 ppt. In contrast, Zostera had no significant structural differences. For both species, there were no differences in shoot or root/rhizome weights in any treatment, nor were there differences in isotopic results due to salinity. However, δ15N in the tissue increase

  13. Acute abdomen

    Directory of Open Access Journals (Sweden)

    Wig J


    Full Text Available 550 cases of acute abdomen have been analysed in detail includ-ing their clinical presentation and operative findings. Males are more frequently affected than females in a ratio of 3: 1. More than 45% of patients presented after 48 hours of onset of symptoms. Intestinal obstruction was the commonest cause of acute abdomen (47.6%. External hernia was responsible for 26% of cases of intestinal obstruction. Perforated peptic ulcer was the commonest cause of peritonitis in the present series (31.7% while incidence of biliary peritonitis was only 2.4%.. The clinical accuracy rate was 87%. The mortality in operated cases was high (10% while the over-all mortality rate was 7.5%.

  14. Anti-oxidative stress role of hydrogen-rich saline and its effect of mitogen-activated protein kinases pathway on hepatic injury of severe acute pancreatitis%氢饱和生理盐水在重症急性胰腺炎肝损伤中的抗氧化应激作用及对丝裂原活化蛋白激酶通路的影响

    Institute of Scientific and Technical Information of China (English)

    殷涛; 石乔; 郭闻一; 陈辰; 赵亮; 阿布克力木; 孙荣泽; 梅方超; 李晨


    Objective To investigate the impact of hydrogen-rich saline on mitogen-activated protein kinases (MAPKs) pathway in hepatic reactive oxygen species (ROS) activation in acute necrotizing pancreatiis (ANP) and protective effect of hydrogen-rich saline on hepatic injury of ANP in rat.Methods Ninety male Wistar rats were randomly divided into three groups:sham operation group (SO group),ANP group and hydrogen-rich saline treatment group (HRS group),each group further divided into three (3,12,24 h) subgroup (n =10).ANP model was induced by retrograde infusion of 5% sodium taurocholate into the biliopancreatic duct.Hydrogen-rich saline was injected through the tail vein (6 ml/kg) and under the skin (20 ml/kg) at 5 minutes after the operation in HRS group.The rats of SO group and ANP group were administered by intravenous (6 ml/kg) and subcutaneous (20 ml/kg) injection with saline.Rats in each group were sacrificed at 3,12 and 24 h after the operation.The levels of serum amylase (AMY),lipase (LIP),alanine transaminase (ALT),aspartate aminotransferase (AST) and histopathological scores or grades of pancreatic and liver tissues were measured.Hepatic malondialdehyde content and superoxide dismutase activity were analyzed.Results The levels of serum AMY (U/L) (5 385 ± 572 vs.1 146±121),LIP (U/L) (1 924.9±105.4vs.86.5±8.9),ALT (U/L) (156.9±15.8 vs.56.1±5.4),AST (U/L) (448.5 ±53.0 vs.124.6 ± 14.7),and histopathological scores of pancreatic tissues (13.79 ± 1.36 vs.0.38 ±0.53) in ANP group increased significantly than SO group (P <0.05).serum AMY (U/L) (5 567 ±512 vs.5 385 ±572) and LIP (U/L) (1 856.8 ± 149.3 vs.1 924.9 ± 105.4) in HRS group decreased than ANP group,but no statistical significance (P > 0.05).serum ALT (U/L) (134.8±11.8 vs.156.9±15.8),AST (U/L) (326.6±20.5 vs.448.5±53.0) and hepatic histopathological grades (17.1 vs.23.1) in HRS group decreased significantly than ANP group (P < 0.05).Hepatic superoxide dismutase activity decreased in ANP

  15. Biodiversity patterns of soil ciliates along salinity gradients. (United States)

    Zhao, Feng; Xu, Kuidong


    We evaluated ciliate diversity in saline soils with a salinity range from 6.5 to 65 psu by the morphological method of the Ludox-quantitative protargol stain (QPS) and the molecular techniques of ciliate-specific clone library and denaturing gradient gel electrophoresis. No active ciliates could be detected with the Ludox-QPS method, while high molecular diversity of ciliates was found. The highest ciliate molecular diversity was obtained from the soil at salinity of 8.9 psu, moderate diversity was found at salinity of 6.5 psu, and the diversity sharply decreased at salinity of 50.5 psu. By contrast, the number of ciliate classes clearly decreased with increasing soil salinity: six, five, four and two classes from sites with salinity of 6.5 psu, 8.9 psu, 29.5 psu and 50.5 psu, respectively. Ciliate diversity pattern is different from that of bacteria, whose diversity is also high in extremely saline environments. Meanwhile, the composition of ciliate community was significantly different along salinity gradient. Colpodea and Oligohymenophorea were diverse in soils at salinity less than 29.5 psu, while absent in soils with salinity above 50.5 psu. BIOENV analysis indicated soil salinity and water content were the main factors regulating the distribution of ciliates in saline soils.

  16. Acute Pancreatitis Concomitant Acute Coronary Syndrome

    Directory of Open Access Journals (Sweden)

    Okay Abacı


    Full Text Available Acute pancreatitis is an inflammatory syndrome with unpredictable progression to systemic inflammation and multi-organ dysfunction. As in our case rarely, acute pancreatitis can be presented with the coexistance of acute coronary syndrome. To prevent a misdiagnosis of acute situation presented with chest or abdominal pain, physicians must be aware for coexisting pathophysiologies and take into account the differential diagnosis of all life-threatening causes such as cardiac ischemia or acute abdominal situations.

  17. Mobility Challenges

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Lassen, Claus


    This article takes point of departure in the challenges to understand the importance of contemporary mobility. The approach advocated is a cross-disciplinary one drawing on sociology, geography, urban planning and design, and cultural studies. As such the perspective is to be seen as a part of th...... mobilities. In particular the article discusses 1) the physical city, its infrastructures and technological hardware/software, 2) policies and planning strategies for urban mobility and 3) the lived everyday life in the city and the region.......This article takes point of departure in the challenges to understand the importance of contemporary mobility. The approach advocated is a cross-disciplinary one drawing on sociology, geography, urban planning and design, and cultural studies. As such the perspective is to be seen as a part...... of the so-called ‘mobility turn’ within social science. The perspective is illustrative for the research efforts at the Centre for Mobility and Urban Studies (C-MUS), Aalborg University. The article presents the contours of a theoretical perspective meeting the challenges to research into contemporary urban...

  18. Ceftriaxone attenuates acute cocaine‐evoked dopaminergic neurotransmission in the nucleus accumbens of the rat (United States)

    Rasmussen, B A; Tallarida, C S; Scholl, J L; Forster, G L; Unterwald, E M; Rawls, S M


    Background and Purpose Ceftriaxone is a β‐lactam antibiotic and glutamate transporter activator that reduces the reinforcing effects of psychostimulants. Ceftriaxone also reduces locomotor activation following acute psychostimulant exposure, suggesting that alterations in dopamine transmission in the nucleus accumbens contribute to its mechanism of action. In the present studies we tested the hypothesis that pretreatment with ceftriaxone disrupts acute cocaine‐evoked dopaminergic neurotransmission in the nucleus accumbens. Experimental Approach Adult male Sprague–Dawley rats were pretreated with saline or ceftriaxone (200 mg kg−1, i.p. × 10 days) and then challenged with cocaine (15 mg kg−1, i.p.). Motor activity, dopamine efflux (via in vivo microdialysis) and protein levels of tyrosine hydroxylase (TH), the dopamine transporter and organic cation transporter as well as α‐synuclein, Akt and GSK3β were analysed in the nucleus accumbens. Key Results Ceftriaxone‐pretreated rats challenged with cocaine displayed reduced locomotor activity and accumbal dopamine efflux compared with saline‐pretreated controls challenged with cocaine. The reduction in cocaine‐evoked dopamine levels was not counteracted by excitatory amino acid transporter 2 blockade in the nucleus accumbens. Pretreatment with ceftriaxone increased Akt/GSK3β signalling in the nucleus accumbens and reduced levels of dopamine transporter, TH and phosphorylated α‐synuclein, indicating that ceftriaxone affects numerous proteins involved in dopaminergic transmission. Conclusions and Implications These results are the first evidence that ceftriaxone affects cocaine‐evoked dopaminergic transmission, in addition to its well‐described effects on glutamate, and suggest that its ability to attenuate cocaine‐induced behaviours, such as psychomotor activity, is due in part to reduced dopaminergic neurotransmission in the nucleus accumbens. PMID:26375494

  19. The Impact of Different Fertigation Practices and Initial Soil Salinity on Soil N and Salinity Transport

    Directory of Open Access Journals (Sweden)

    Zeng Wen-zhi


    Full Text Available For studying the impact of different fertigation practices and initial soil salinity on soil N and salinity transport, large Plexi-glass columns (18.2 cm in diameter and 100 cm long assembled from sandy loam (Inner Mongolia and saturation optimum design were employed to simulate a range of initial soil salinity conditions in soil profile and fertigation practices. (4~8 L solution with 20 g urea dissolved was applied evenly and slowly to the surface of each column. Nitrate and ammonium nitrogen in soil and discharge from the outlet were sampled and the electrical conductivity of soil and the chloride ion concentration of discharges were also measured. Findings from this study include: (1 high initial salinity in soil had a certain impact on the changes of water content of vertical soil section with the time being after large amount of water irrigation and it might increase the rate of infiltration; (2 the amount of irrigation water significantly affected the transport of soil salinity; (3 high soil salinity content was likely to promote the conversion of urea nitrogen to ammonium nitrogen and it might also play an active role in ammonium nitrogen accumulation in drainage; (4 There is a sound linear relation between the cumulative content of chloride ion and that of nitrate nitrogen in the drainage and soil profile (r2 = 0.8221 and 0.7442.

  20. Transport Characteristics of Soil Salinity in Saline-alkali Land under Water Storage and Drainage Conditions

    Institute of Scientific and Technical Information of China (English)

    Juan; LI; Jichang; HAN


    To test the variation and transport of soil salinity in saline- alkali land under water storage and drainage treatments,an experimental model was established in Fuping,Shaanxi Province,2009. The variation of soil salinity during 0- 160 cm soil depth under the two treatments was determined and analyzed. Results showed that the average soil water content under water storage treatment was 4. 47% higher than that under drainage treatment,which means that the water storage treatment could help to improve soil moisture to satisfy the crop’s growth needs. The profile distribution of soil soluble solids( TDS),anion( Cl-,HCO3-,SO2-4) and cation( Ca2 +,Na+,K+) content and the variation of soil p H were also measured and analyzed. PCA( Principal Component Analysis) was used to explore the relationship between the soil salinity and its ions,which showed that the water storage treatment could significantly decrease the surface salinity of soil and accelerate the desalination of topsoils,and finally,the soil quality was improved significantly,demonstrating that the water storage treatment has a remarkable effect on soil salinity management.


    Directory of Open Access Journals (Sweden)



    Full Text Available This study was contemplated to determine the comparative beneficial effects of hypertonic saline solution and sterile saline solution in induced endotoxic shock in dogs. For this purpose, 12 healthy Mongrel dogs were randomly divided into two equal groups (A and B. All the animals were induced endotoxaemia by slow intravenous administration of Escherichia coli endotoxins 0111:B4. Group A was treated with normal saline solution @ 90 ml/kg BW, while group B was given hypertonic saline solution @ 4 ml/kg BW, followed by normal saline solution @ 10 ml/kg BW. Different parameters were observed for evaluation of these fluids including clinical and haematological parameters, serum electrolytes, mean arterial pressure, and blood gases at different time intervals up to 24 hours post treatments. After infusion of respective fluids, all parameters returned to baseline values in both the groups but group B showed better results than group A except bicarbonates, which better recovered in group A. Thus, it was concluded that a small-volume of hypertonic saline solution could be effectively used in reversing the endotoxaemia. Moreover, it provides a rapid and inexpensive resuscitation from endotoxic shock.

  2. Acute viral bronchiolitis in South Africa: Strategies for management and prevention. (United States)

    Zar, H J; Madhi, S A; White, D A; Masekela, R; Risenga, S; Lewis, H; Feldman, C; Morrow, B; Jeena, P


    Management of acute viral bronchiolitis is largely supportive. There is currently no proven effective therapy other than oxygen for hypoxic children. The evidence indicates that there is no routine benefit from inhaled, rapid short-acting bronchodilators, adrenaline or ipratropium bromide for children with acute viral bronchiolitis. Likewise, there is no demonstrated benefit from routine use of inhaled or oral corticosteroids, inhaled hypertonic saline nebulisation, montelukast or antibiotics. The last should be reserved for children with severe disease, when bacterial co-infection is suspected. Prevention of respiratory syncytial virus (RSV) disease remains a challenge. A specific RSV monoclonal antibody, palivizumab, administered as an intramuscular injection, is available for children at risk of severe bronchiolitis, including premature infants, young children with chronic lung disease, immunodeficiency, or haemodynamically significant congenital heart disease. Prophylaxis should be commenced at the start of the RSV season and given monthly during the season. The development of an RSV vaccine may offer a more effective alternative to prevent disease, for which the results of clinical trials are awaited. Education of parents or caregivers and healthcare workers about diagnostic and management strategies should include the following: bronchiolitis is caused by a virus; it is seasonal; it may start as an upper respiratory tract infection with low-grade fever; symptoms are cough and wheeze, often with fast breathing; antibiotics are generally not needed; and the condition is usually self limiting, although symptoms may occur for up to four weeks in some children.

  3. Environmental factors affecting challenge success in vaccination studies

    DEFF Research Database (Denmark)

    Chettri, Jiwan Kumar; Skov, Jakob; Dalsgaard, Inger

    following vaccination, the administration of the pathogen is important for the outcome of the experiments. We have therefore also compared injection challenge with cohabitation challenge. In addition, when doing so we also investigated the influence of environmental conditions such as salinity......We have tested the efficacies of two different vaccines (a commercial versus an experimental vaccine – both being oil adjuvanted) for rainbow trout against furunculosis caused by Aeromonas salmonicida infections. However, when challenging fish with live bacteria in order to assess protection...... and temperature on the protection recorded. Thus, challenge studies were conducted at two temperatures (12 and 19°C) and at two salinities (0 and 15 ppt). Mortalities following challenge were recorded and RPS calculated for each group. Side effects of the vaccines were evaluated by using the Speilberg scale...

  4. Environmental factors affecting challenge success in vaccination studies

    DEFF Research Database (Denmark)

    Chettri, J. K.; Skov, J.; Dalsgaard, Inger


    following vaccination, the administration of the pathogen is important for the outcome of the experiments. We have therefore also compared injection challenge with cohabitation challenge. In addition, when doing so we also investigated the influence of environmental conditions such as salinity......We have tested the efficacies of two different vaccines (a commercial versus an experimental vaccine – both being oil adjuvanted) for rainbow trout against furunculosis caused by Aeromonas salmonicida infections. However, when challenging fish with live bacteria in order to assess protection...... and temperature on the protection recorded. Thus, challenge studies were conducted at two temperatures (12 and 19°C) and at two salinities (0 and 15 ppt). Mortalities following challenge were recorded and RPS calculated for each group. Side effects of the vaccines were evaluated by using the Speilberg scale...

  5. Global Temperature and Salinity Profile Programme (GTSPP) Data (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Global Temperature-Salinity Profile Programme (GTSPP) develops and maintains a global ocean temperature and salinity resource with data that are both up-to-date...

  6. Climate change and soil salinity: The case of coastal Bangladesh. (United States)

    Dasgupta, Susmita; Hossain, Md Moqbul; Huq, Mainul; Wheeler, David


    This paper estimates location-specific soil salinity in coastal Bangladesh for 2050. The analysis was conducted in two stages: First, changes in soil salinity for the period 2001-2009 were assessed using information recorded at 41 soil monitoring stations by the Soil Research Development Institute. Using these data, a spatial econometric model was estimated linking soil salinity with the salinity of nearby rivers, land elevation, temperature, and rainfall. Second, future soil salinity for 69 coastal sub-districts was projected from climate-induced changes in river salinity and projections of rainfall and temperature based on time trends for 20 Bangladesh Meteorological Department weather stations in the coastal region. The findings indicate that climate change poses a major soil salinization risk in coastal Bangladesh. Across 41 monitoring stations, the annual median projected change in soil salinity is 39 % by 2050. Above the median, 25 % of all stations have projected changes of 51 % or higher.

  7. Penaeid Shrimp Salinity Gradient Tank Study 2005-2008 (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — We designed an experimental gradient tank to examine salinity preferences of juvenile brown shrimp and white shrimp. Although no strong pattern of salinity avoidance...

  8. Spatio-temporal analysis of multi-year Landsat 7 data for regional scale soil salinity assessment (United States)

    Despite decades of research in soil mapping, characterizing the spatial variability of soil salinity across broad regions remains a crucial challenge. This work explores the potential benefits of employing reflectance data from the six spectral bands (blue, 450-520 nrn; green, 520-600 nrn; red, 630-...

  9. Effects of Salinity on Oil Spill Dispersant Toxicity in Estuarine Organisms (United States)

    Eckmann, C. A.


    Chemical dispersants can be a useful tool to mitigate oil spills, but the potential risks to sensitive estuarine species should be carefully considered. To improve the decision making process, more information is needed regarding the effects of oil spill dispersants on the health of coastal ecosystems under variable environmental conditions such as salinity. The two oil dispersants used in this study were Corexit ® 9500 and Finasol ® OSR 52. Corexit ® 9500 was the primary dispersant used during the 2010 Deepwater Horizon oil spill event, while Finasol® OSR 52 is another dispersant approved for oil spill response in the U.S., yet considerably less is known regarding its toxicity to estuarine species. The grass shrimp, Palaemonetes pugio, was used as a model estuarine species. It is a euryhaline species that tolerates salinities from brackish to full strength seawater. Adult and larval life stages were tested with each dispersant at three salinities, 5ppt, 20ppt, and 30ppt. Median acute lethal toxicity thresholds were calculated. Lipid peroxidation assays were conducted on surviving shrimp to investigate sublethal effects. The toxicity of both dispersants was significantly influenced by salinity, with greatest toxicity observed at the lowest salinity tested. Larval shrimp were significantly more sensitive than adult shrimp to both dispersants, and both life stages were significantly more sensitive to Finasol than to Corexit. Furthermore, significant sublethal effects were seen at higher concentrations of both dispersants compared to the control. These data will enable environmental managers to make informed decisions regarding dispersant use in future oil spills.

  10. Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats.

    Directory of Open Access Journals (Sweden)

    Yunye Ning

    Full Text Available BACKGROUND: Over-production of mucus is an important pathophysiological feature in chronic airway disease such as chronic obstructive pulmonary disease (COPD and asthma. Cigarette smoking (CS is the leading cause of COPD. Oxidative stress plays a key role in CS-induced airway abnormal mucus production. Hydrogen protected cells and tissues against oxidative damage by scavenging hydroxyl radicals. In the present study we investigated the effect of hydrogen on CS-induced mucus production in rats. METHODS: Male Sprague-Dawley rats were divided into four groups: sham control, CS group, hydrogen-rich saline pretreatment group and hydrogen-rich saline control group. Lung morphology and tissue biochemical changes were determined by immunohistochemistry, Alcian Blue/periodic acid-Schiff staining, TUNEL, western blot and realtime RT-PCR. RESULTS: Hydrogen-rich saline pretreatment attenuated CS-induced mucus accumulation in the bronchiolar lumen, goblet cell hyperplasia, muc5ac over-expression and abnormal cell apoptosis in the airway epithelium as well as malondialdehyde increase in the BALF. The phosphorylation of EGFR at Tyr1068 and Nrf2 up-regulation expression in the rat lungs challenged by CS exposure were also abrogated by hydrogen-rich saline. CONCLUSION: Hydrogen-rich saline pretreatment ameliorated CS-induced airway mucus production and airway epithelium damage in rats. The protective role of hydrogen on CS-exposed rat lungs was achieved at least partly by its free radical scavenging ability. This is the first report to demonstrate that intraperitoneal administration of hydrogen-rich saline protected rat airways against CS damage and it could be promising in treating abnormal airway mucus production in COPD.

  11. Hypertonic saline is more effective than normal saline in seasonal allergic rhinitis in children. (United States)

    Marchisio, P; Varricchio, A; Baggi, E; Bianchini, S; Capasso, M E; Torretta, S; Capaccio, P; Gasparini, C; Patria, F; Esposito, S; Principi, N


    Allergic rhinitis (AR) is a very common childhood disease that is associated with a significant reduction in the patients' quality of life. Its treatment combines educating the patients and their parents, immunotherapy and drug administration. However, even the best approach does not relieve the symptoms of a number of patients. Alternative therapies are particularly needed for children because the fear of adverse events frequently reduces parental compliance to the prescribed drugs, and immunotherapy is less easy to administer than in adults. In this prospective investigator-blinded study we evaluated whether children, with a documented history of seasonal grass pollen-related AR, benefit from nasal irrigation by assessing the effects on nasal signs and symptoms, on middle ear effusion and on adenoidal hypertrophy. We randomized children aged 5 to 9 years (median age 82 months) to normal saline or hypertonic saline (a 2.7% sodium chloride solution), administered twice-daily using a disposable 20 ml syringe, or no treatment. Nasal symptoms (rhinorrhea, itching, sneezing, nasal obstruction), swelling of turbinates, adenoid hypertrophy or middle ear effusion were assessed at baseline and after 4 weeks of treatment. Two hundred and twenty children (normal saline: 80; hypertonic saline: 80; no treatment: 60) completed the study. After four weeks, all the considered items were significantly reduced in the group receiving hypertonic saline (P < 0.0001), whereas in the group receiving normal saline only rhinorrhea (P = 0.0002) and sneezing (P = 0.002) were significantly reduced. There was no significant change in any of the items in the control group. The duration of oral antihistamines was significantly lower in the children receiving hypertonic saline than in those treated with normal saline or in controls. No adverse events were reported and parental satisfaction and compliance with the procedure were globally very good, regardless of the solution used. Using our

  12. Shallow rainwater lenses in deltaic areas with saline seepage

    NARCIS (Netherlands)

    Louw, de P.G.B.; Eeman, S.; Siemon, B.; `Voortman, B.R.; Gunnink, J.; Baaren, E.S.; Oude Essink, G.H.P.


    In deltaic areas with saline seepage, freshwater availability is often limited to shallow rainwater lenses lying on top of saline groundwater. Here we describe the characteristics and spatial variability of such lenses in areas with saline seepage and the mechanisms that control their occurrence and

  13. Shallow rainwater lenses in deltaic areas with saline seepage

    NARCIS (Netherlands)

    De Louw, Perry G.B.; Eeman, Sara; Siemon, Bernhard; Voortman, Bernard R.; Gunnink, Jan; Van Baaren, Esther S.; Oude Essink, Gualbert


    In deltaic areas with saline seepage, fresh water availability is often limited to shallow rainwater lenses lying on top of saline groundwater. Here we describe the characteristics and spatial variability of such lenses in areas with saline seepage and the mechanisms that control their occurrence an

  14. 76 FR 61382 - Colorado River Basin Salinity Control Advisory Council (United States)


    ... Bureau of Reclamation Colorado River Basin Salinity Control Advisory Council AGENCY: Bureau of Reclamation, Interior. ACTION: Notice of public meeting. ] SUMMARY: The Colorado River Basin Salinity Control Advisory Council (Council) was established by the Colorado River Basin Salinity Control Act of 1974 (Pub....

  15. 75 FR 25877 - Colorado River Basin Salinity Control Advisory Council (United States)


    ... Bureau of Reclamation Colorado River Basin Salinity Control Advisory Council AGENCY: Bureau of Reclamation, Interior. ACTION: Notice of public meeting. SUMMARY: The Colorado River Basin Salinity Control Advisory Council (Council) was established by the Colorado River Basin Salinity Control ] Act of 1974...

  16. 78 FR 70574 - Colorado River Basin Salinity Control Advisory Council (United States)


    ....20350010.REG0000, RR04084000] Colorado River Basin Salinity Control Advisory Council AGENCY: Bureau of Reclamation, Interior. ACTION: Notice of public meeting. SUMMARY: The Colorado River Basin Salinity Control Advisory Council (Council) was established by the Colorado River Basin Salinity Control Act of 1974 (Pub....

  17. 77 FR 23508 - Colorado River Basin Salinity Control Advisory Council (United States)


    ... Bureau of Reclamation Colorado River Basin Salinity Control Advisory Council AGENCY: Bureau of Reclamation, Interior. ACTION: Notice of public meeting. SUMMARY: The Colorado River Basin Salinity Control Advisory Council (Council) was established by the Colorado River Basin Salinity Control Act of 1974 (Pub....

  18. 75 FR 27360 - Colorado River Basin Salinity Control Advisory Council (United States)


    ... Bureau of Reclamation Colorado River Basin Salinity Control Advisory Council AGENCY: Bureau of Reclamation, Interior. ACTION: Notice of public meeting. SUMMARY: The Colorado River Basin Salinity Control Advisory Council (Council) was established by the Colorado River Basin Salinity Control Act of 1974 (Pub....

  19. 75 FR 66389 - Colorado River Basin Salinity Control Advisory Council (United States)


    ... Bureau of Reclamation Colorado River Basin Salinity Control Advisory Council AGENCY: Bureau of Reclamation, Interior. ACTION: Notice of public meeting. SUMMARY: The Colorado River Basin Salinity Control Advisory Council (Council) was established by the Colorado River Basin Salinity Control Act of 1974 (Pub....

  20. Palaeoclimatic Indicators of China's Quaternary Saline Lake Sediments and Hydrochemistry

    Institute of Scientific and Technical Information of China (English)


    In this paper the authors classify saline lake sediments into the cold, warm and eurythermal phases, reveal the consistency between the zoning of hydrochemical types of modern saline lake water and climatic zoning and give climatic parameters under the conditions of typical cold phase (mirabilite and natron), warm phase (thenardite) and slightly warm phase (bloedite) saline lake deposition.

  1. 77 FR 61784 - Colorado River Basin Salinity Control Advisory Council (United States)


    ... Bureau of Reclamation Colorado River Basin Salinity Control Advisory Council AGENCY: Bureau of Reclamation, Interior. ACTION: Notice of public meeting. SUMMARY: The Colorado River Basin Salinity Control Advisory Council (Council) was established by the Colorado River Basin Salinity Control Act of 1974 (Pub....

  2. 78 FR 23784 - Colorado River Basin Salinity Control Advisory Council (United States)


    ... Bureau of Reclamation Colorado River Basin Salinity Control Advisory Council AGENCY: Bureau of Reclamation, Interior. ACTION: Notice of public meeting. SUMMARY: The Colorado River Basin Salinity Control Advisory Council (Council) was established by the Colorado River Basin Salinity Control Act of 1974...

  3. Acute Rhabdomyolysis Following Synthetic Cannabinoid Ingestion


    Adedinsewo, Demilade A.; Oluwaseun Odewole; Taylor Todd


    Context: Novel psychoactive substances, including synthetic cannabinoids, are becoming increasingly popular, with more patients being seen in the emergency room following acute ingestion. These substances have been associated with a wide range of adverse effects. However, identification of complications, clinical toxicity, and management remain challenging. Case Report: We present the case of a young African-American male who developed severe agitation and bizarre behavior following acute K2 ...

  4. Challenging Identities

    DEFF Research Database (Denmark)

    Keydar, Ceglar; Marin, Manuela; Janik, Allan;

    , cultural, and political practices. Notions of national identity and national politics are challenged by European integration, as well as by increasing demographic heterogeneity due to migration, and migrants experience conflicts of identification stemming from clashes between cultural heritage...... and the cultures of the new habitat. European horizons—frames of mind, historical memories, and expectations at the level of groups or communities, at the national level, and at the general European level—are at odds. Analyzing a series of issues in European countries from Turkey to Spain and from Scandinavia...

  5. Sexually dimorphic effects of neonatal immune system activation with lipopolysaccharide on the behavioural response to a homotypic adult immune challenge. (United States)

    Tenk, Christine M; Kavaliers, Martin; Ossenkopp, Klaus-Peter


    Research has shown that acute immune activation during the early postnatal period with the Gram-negative endotoxin, lipopolysaccharide (LPS), alters a variety of physiological and behavioural processes in the adult animal. For example, neonatal LPS exposure affects disease susceptibility later in life, though these effects appear to be modulated by time of exposure, sex, and immune stimulus. The current study examined sex differences in the effect of neonatal LPS treatment on the locomotor activity response to adult LPS administration. Male and female Long-Evans rats were treated systemically with either LPS (50 microg/kg) or saline (0.9%) on postnatal days 3 and 5. Later in adulthood (postnatal day 92), all animals were subjected to an adult LPS challenge and were injected (i.p.) with 200 microg/kg LPS. Two hours after injection, animals were placed in a non-novel open-field and locomotor activity was assessed for 30 min. Body weights were determined both at the time of injection and 24h later to examine LPS-induced weight loss. Adult males treated neonatally with LPS exhibited significantly less horizontal and vertical activity in response to the LPS challenge relative to males treated neonatally with saline. This effect was not observed in females. Thus, the current study provides important evidence of sexual dimorphism in the long-term effects of neonatal LPS exposure on the responses to an adult homotypic immune challenge in rats. These findings have potential clinical significance given that neonatal exposure to pathogens is a fairly common occurrence and Gram-negative bacteria are a common cause of neonatal bacterial infections.

  6. The Friction of Saline Ice on Aluminium

    Directory of Open Access Journals (Sweden)

    Christopher Wallen-Russell


    Full Text Available The friction of ice on other materials controls loading on offshore structures and vessels in the Arctic. However, ice friction is complicated, because ice in nature exists near to its melting point. Frictional heating can cause local softening and perhaps melting and lubrication, thus affecting the friction and creating a feedback loop. Ice friction is therefore likely to depend on sliding speed and sliding history, as well as bulk temperature. The roughness of the sliding materials may also affect the friction. Here we present results of a series of laboratory experiments, sliding saline ice on aluminium, and controlling for roughness and temperature. We find that the friction of saline ice on aluminium μice-al=0.1 typically, but that this value varies with sliding conditions. We propose physical models which explain the variations in sliding friction.

  7. Microwave Radiometric Measurement of Sea Surface Salinity. (United States)


    potential problems of polution and urban water sup- plies. Although salinity can be measured from a surface vessel, economic consider- ations advocate...Washington, DC 20350 Commander Naval Sea System Commandaa ComAinder ATTN: Mr. C. Smith, NAVSEA 63R* Nval Air Development Center "’-’. "Washington, DC...20362 ATTN: Mr. R. Bollard, Code 2062% .’* Warminster, PA 18974 • .’.Commander CNaval Sea System CommandCoimCander Headquarters Naval Air Systems

  8. Data Challenges

    CERN Multimedia

    McCubbin, N A

    Some two years ago we planned a series of Data Challenges starting at the end of 2001. At the time, that seemed to be comfortingly far in the future... Well, as the saying goes, doesn't time fly when you are having fun! ATLAS Computing is now deep in the throes of getting the first Data Challenge (DC0) up and running. One of the main aims of DC0 is to have a software 'release' in which we can generate full physics events, track all particles through the detector, simulate the detector response, reconstruct the event, and study it, with appropriate data storage en route. As all software is "always 95% ready" (!), we have been able to do most of this, more or less, for some time. But DC0 forces us to have everything working, together, at the same time: a reality check. DC0 should finish early next year, and it will be followed almost immediately afterwards by DC1 (DC0 was foreseen as the 'check' for DC1). DC1 will last into the middle of 2002, and has two major goals. The first is generation, simulation, and r...

  9. Survival, growth and reproduction of non-indigenous Nile tilapia, Oreochromis niloticus (Linnaeus 1758). I. Physiological capabilities in various temperatures and salinities (United States)

    Schofield, Pamela J.; Peterson, Mark S.; Lowe, Michael R.; Brown-Peterson, Nancy J.; Slack, William T.


    The physiological tolerances of non-native fishes is an integral component of assessing potential invasive risk. Salinity and temperature are environmental variables that limit the spread of many non-native fishes. We hypothesised that combinations of temperature and salinity will interact to affect survival, growth, and reproduction of Nile tilapia, Oreochromis niloticus, introduced into Mississippi, USA. Tilapia withstood acute transfer from fresh water up to a salinity of 20 and survived gradual transfer up to 60 at typical summertime (30°C) temperatures. However, cold temperature (14°C) reduced survival of fish in saline waters ≥10 and increased the incidence of disease in freshwater controls. Although fish were able to equilibrate to saline waters in warm temperatures, reproductive parameters were reduced at salinities ≥30. These integrated responses suggest that Nile tilapia can invade coastal areas beyond their point of introduction. However, successful invasion is subject to two caveats: (1) wintertime survival depends on finding thermal refugia, and (2) reproduction is hampered in regions where salinities are ≥30. These data are vital to predicting the invasion of non-native fishes into coastal watersheds. This is particularly important given the predicted changes in coastal landscapes due to global climate change and sea-level rise.

  10. Chemical and isotopic constrains on the origin of brine and saline groundwater in Hetao plain, Inner Mongolia. (United States)

    Liu, Jun; Chen, Zongyu; Wang, Lijuan; Zhang, Yilong; Li, Zhenghong; Xu, Jiaming; Peng, Yurong


    The origin and evolution of brine and saline groundwater have always been a challenged work for geochemists and hydrogeologists. Chemical and isotopic data of brine and saline waters were used to trace the sources of salinity and therefore to understand the transport mechanisms of groundwater in Xishanzui, Inner Mongolia. Both Cl/Br (molar) versus Na/Br (molar) and Cl (meq/L) versus Na (meq/L) indicated that salinity was from halite dissolution or at least a significant impact by halite dissolution. The logarithmic plot of the concentration trends of Cl (mg/L) versus Br (mg/L) for the evaporation of seawater and the Qinghai Salt Lake showed that the terrestrial halite dissolution was the dominated contribution for the salinity of this brine. The stable isotope ratios of hydrogen and oxygen suggested that the origin of brine was from paleorecharge water which experienced mixing of modern water in shallow aquifer. δ(37)Cl values ranged from -0.02 to 3.43 ‰ (SMOC), and reflecting mixing of different sources. The Cl isotopic compositions suggest that the dissolution of halite by paleometeoric water had a great contribution to the salinity of brine, and the contributions of the residual seawater and the dissolution of halite by the Yellow River water could be excluded.

  11. Incorporation of salinity in Water Availability Modeling (United States)

    Wurbs, Ralph A.; Lee, Chihun


    SummaryNatural salt pollution from geologic formations in the upper watersheds of several large river basins in the Southwestern United States severely constrains the use of otherwise available major water supply sources. The Water Rights Analysis Package modeling system has been routinely applied in Texas since the late 1990s in regional and statewide planning studies and administration of the state's water rights permit system, but without consideration of water quality. The modeling system was recently expanded to incorporate salinity considerations in assessments of river/reservoir system capabilities for supplying water for environmental, municipal, agricultural, and industrial needs. Salinity loads and concentrations are tracked through systems of river reaches and reservoirs to develop concentration frequency statistics that augment flow frequency and water supply reliability metrics at pertinent locations for alternative water management strategies. Flexible generalized capabilities are developed for using limited observed salinity data to model highly variable concentrations imposed upon complex river regulation infrastructure and institutional water allocation/management practices.

  12. Acute arterial occlusion - kidney (United States)

    Acute renal arterial thrombosis; Renal artery embolism; Acute renal artery occlusion; Embolism - renal artery ... kidney can often result in permanent kidney failure. Acute arterial occlusion of the renal artery can occur after injury or trauma to ...

  13. Acute cerebellar ataxia (United States)

    Cerebellar ataxia; Ataxia - acute cerebellar; Cerebellitis; Post-varicella acute cerebellar ataxia; PVACA ... Acute cerebellar ataxia in children, especially younger than age 3, may occur several weeks after an illness caused by a virus. ...

  14. Why Is Saline So Acidic (and Does It Really Matter?)


    Reddi, Benjamin AJ


    Commercial 0.9% saline solution for infusion has a pH around 5.5. There are many reasons for this acidity, some of them still obscure. It is also true that infusion of normal saline can lead to metabolic acidaemia, yet the link between the acidity of saline solution and the acidaemia it can engender is not straightforward. This commentary draws together the known and putative sources of acidity in saline solutions: it turns out that the acidity of saline solution is essentially unrelated to t...

  15. River salinity on a mega-delta, an unstructured grid model approach. (United States)

    Bricheno, Lucy; Saiful Islam, Akm; Wolf, Judith


    With an average freshwater discharge of around 40,000 m3/s the BGM (Brahmaputra Ganges and Meghna) river system has the third largest discharge worldwide. The BGM river delta is a low-lying fertile area covering over 100,000 km2 mainly in India and Bangladesh. Approximately two-thirds of the Bangladesh people work in agriculture and these local livelihoods depend on freshwater sources directly linked to river salinity. The finite volume coastal ocean model (FVCOM) has been applied to the BGM delta in order to simulate river salinity under present and future climate conditions. Forced by a combination of regional climate model predictions, and a basin-wide river catchment model, the 3D baroclinic delta model can determine river salinity under the current climate, and make predictions for future wet and dry years. The river salinity demonstrates a strong seasonal and tidal cycle, making it important for the model to be able to capture a wide range of timescales. The unstructured mesh approach used in FVCOM is required to properly represent the delta's structure; a complex network of interconnected river channels. The model extends 250 km inland in order to capture the full extent of the tidal influence and grid resolutions of 10s of metres are required to represent narrow inland river channels. The use of FVCOM to simulate flows so far inland is a novel challenge, which also requires knowledge of the shape and cross-section of the river channels.

  16. The complementary role of SMOS sea surface salinity observations for estimating global ocean salinity state (United States)

    Lu, Zeting; Cheng, Lijing; Zhu, Jiang; Lin, Renping


    Salinity is a key ocean state property, changes in which reveal the variation of the water cycle and the ocean thermohaline circulation. However, prior to this century, in situ salinity observations were extremely sparse, which decreased the reliability of simulations of ocean general circulation by ocean and climate models. In 2009, sea surface salinity (SSS) observations covered the global ocean via the European Space Agency's Soil Moisture and Ocean Salinity (SMOS) mission, and several versions of global SSS products were subsequently released. How can these data benefit model performance? Previous studies found contradictory results. In this work, we assimilated SMOS-SSS data into the LASG/IAP Climate system Ocean Model (LICOM) using the Ensemble Optimum Interpolation (EnOI) assimilation scheme. To assess and quantify the contribution of SMOS-SSS data to model performance, several tests were conducted. The results indicate that the CECOS/CATDS 2010.V02 SMOS-SSS product can significantly improve model simulations of sea surface/subsurface salinity fields. This study provides the basis for the future assimilation of SMOS-SSS data for short-range climate forecasting.

  17. Effect of Initial Soluble Salt Composition of Saline Soil on Salinity Tolerance of Barley Plant

    Institute of Scientific and Technical Information of China (English)



    A pot experiment was carried out on a marine saline soil to study the effect of initial soluble Na/Ca ratio of saline soil on the salinity tolerance of barley plant.The results showed that (1) the Na/Ca ratio affected significantly the dry weight of the plant at an earlier stage of growth,the critical values of initial Na/Ca ratio at which the plant could grow normally on soils containing salts of 2.5,3.5 and 4.5g kg-1 were 30,20 and 15,respectively;(2)smaller Na/Ca ratio resulted in a considerable decrease in Na accumulation but a great increase in K accumulation in the barley plant;and (3) the plasmallema of barley leaf were badly injured when the Na/Ca ratio was more than 30 and the increase of Na content of plant caused an exudation of K from the leaf cells.Some critical indexes were suggested for the cultivation of barley plant on marine saline soils and could be used as reference in the biological reclamation of marine saline soils.

  18. SPS Challenges

    CERN Document Server

    Chapochnikova, Elena


    In future the SPS should be able to transfer to the LHC the beam produced by a completely new pre-injector chain and required by the LHC for different upgrade scenarios. The issues related to this extremely challenging task are presented together with some possible ways of overcoming the problems that arise. Besides an increase in injection energy provided by PS2, these measures can include both an SPS vacuum chamber upgrade against the e-cloud and operation with larger longitudinal emittance for beam stability. As a result the power plant of the SPS RF system must be doubled. The SPS upgrade will also need the improvement or replacement of many other machine elements.

  19. Evaluating physiological responses of plants to salinity stress

    KAUST Repository

    Negrão, S.


    Background Because soil salinity is a major abiotic constraint affecting crop yield, much research has been conducted to develop plants with improved salinity tolerance. Salinity stress impacts many aspects of a plant’s physiology, making it difficult to study in toto. Instead, it is more tractable to dissect the plant’s response into traits that are hypothesized to be involved in the overall tolerance of the plant to salinity. Scope and conclusions We discuss how to quantify the impact of salinity on different traits, such as relative growth rate, water relations, transpiration, transpiration use efficiency, ionic relations, photosynthesis, senescence, yield and yield components. We also suggest some guidelines to assist with the selection of appropriate experimental systems, imposition of salinity stress, and obtaining and analysing relevant physiological data using appropriate indices. We illustrate how these indices can be used to identify relationships amongst the proposed traits to identify which traits are the most important contributors to salinity tolerance. Salinity tolerance is complex and involves many genes, but progress has been made in studying the mechanisms underlying a plant’s response to salinity. Nevertheless, several previous studies on salinity tolerance could have benefited from improved experimental design. We hope that this paper will provide pertinent information to researchers on performing proficient assays and interpreting results from salinity tolerance experiments.

  20. Refined Modeling of Water Temperature and Salinity in Coastal Areas

    Institute of Scientific and Technical Information of China (English)

    SHEN Yongming; ZHENG Yonghong; QIU Dahong


    The prediction of water temperature and salinity in coastal areas is one of the essential tasks in water quality control and management. This paper takes a refined forecasting model of water temperature and salinity in coastal areas as a basic target. Based on the Navier-Stokes equation and k- turbulence model, taking the characteristics of coastal areas into account, a refined model for water temperatureand salinity in coastal areas has been developed to simulate the seasonal variations of water temperatureand salinity fields in the Hakata Bay, Japan. The model takes into account the effects of a variety ofhydrodynamic and meteorological factors on water temperature and salinity. It predicts daily fluctuations in water temperature and salinity at different depths throughout the year. The model has been calibrated well against the data set of historical water temperature and salinity observations in the Hakata Bay,Japan.

  1. Challenges of diagnosing acute HIV-1 subtype C infection in African women: performance of a clinical algorithm and the need for point-of-care nucleic-acid based testing.

    Directory of Open Access Journals (Sweden)

    Koleka Mlisana

    Full Text Available BACKGROUND: Prompt diagnosis of acute HIV infection (AHI benefits the individual and provides opportunities for public health intervention. The aim of this study was to describe most common signs and symptoms of AHI, correlate these with early disease progression and develop a clinical algorithm to identify acute HIV cases in resource limited setting. METHODS: 245 South African women at high-risk of HIV-1 were assessed for AHI and received monthly HIV-1 antibody and RNA testing. Signs and symptoms at first HIV-positive visit were compared to HIV-negative visits. Logistic regression identified clinical predictors of AHI. A model-based score was assigned to each predictor to create a risk score for every woman. RESULTS: Twenty-eight women seroconverted after a total of 390 person-years of follow-up with an HIV incidence of 7.2/100 person-years (95%CI 4.5-9.8. Fifty-seven percent reported ≥1 sign or symptom at the AHI visit. Factors predictive of AHI included age <25 years (OR = 3.2; 1.4-7.1, rash (OR = 6.1; 2.4-15.4, sore throat (OR = 2.7; 1.0-7.6, weight loss (OR = 4.4; 1.5-13.4, genital ulcers (OR = 8.0; 1.6-39.5 and vaginal discharge (OR = 5.4; 1.6-18.4. A risk score of 2 correctly predicted AHI in 50.0% of cases. The number of signs and symptoms correlated with higher HIV-1 RNA at diagnosis (r = 0.63; p<0.001. CONCLUSIONS: Accurate recognition of signs and symptoms of AHI is critical for early diagnosis of HIV infection. Our algorithm may assist in risk-stratifying individuals for AHI, especially in resource-limited settings where there is no routine testing for AHI. Independent validation of the algorithm on another cohort is needed to assess its utility further. Point-of-care antigen or viral load technology is required, however, to detect asymptomatic, antibody negative cases enabling early interventions and prevention of transmission.

  2. Acute Appendicitis

    DEFF Research Database (Denmark)

    Tind, Sofie; Qvist, Niels


    BACKGROUND: The classification of acute appendicitis (AA) into various grades is not consistent, partly because it is not clear whether the perioperative or the histological findings should be the foundation of the classification. When comparing results from the literature on the frequency...... patients were included. In 116 (89 %) of these cases, appendicitis was confirmed histological. There was low concordance between the perioperative and histological diagnoses, varying from 16 to 76 % depending on grade of AA. Only 44 % of the patients receiving antibiotics postoperatively had a positive...... peritoneal fluid cultivation. CONCLUSION: There was a low concordance in clinical and histopathological diagnoses of the different grades of appendicitis. Perioperative cultivation of the peritoneal fluid as a standard should be further examined. The potential could be a reduced postoperative antibiotic use...

  3. Effect of water or saline intake on heat-induced limb vasodilation in dehydrated baboons. (United States)

    Ryan, K L; Proppe, D W


    Dehydration markedly attenuates the increase in hindlimb blood flow elicited by environmental heating (EH) in baboons. This study sought to determine the importance of gradually produced increases in body fluid osmolality and decreases in body fluid volume in producing this attenuation. The hindlimb blood flow increases during EH of seven unanesthetized chronically instrumented baboons were examined during euhydration, dehydration (64-68 h of water deprivation), and after ad libitum oral rehydration with either water or a hyperosmotic saline solution. EH consisted of acute exposure to ambient temperatures of 38-42 degrees C until internal temperature reached 39.5 degrees C. Dehydration depressed the maximal external iliac artery blood flow (MIBF) and iliac vascular conductance (IVC) attained during EH in the euhydrated state by 37 and 43%, respectively. Rehydration with either water or saline solution, however, restored maximal MIBF and IVC to euhydrated levels. Because plasma osmolality remained at dehydrated levels after rehydration with saline, hyperosmolality does not produce the dehydration-induced attenuation in hindlimb blood flow.

  4. Durum wheat seedlings in saline conditions: Salt spray versus root-zone salinity (United States)

    Spanò, Carmelina; Bottega, Stefania


    Salinity is an increasingly serious problem with a strong negative impact on plant productivity. Though many studies have been made on salt stress induced by high NaCl concentrations in the root-zone, few data concern the response of plants to saline aerosol, one of the main constraints in coastal areas. In order to study more in depth wheat salinity tolerance and to evaluate damage and antioxidant response induced by various modes of salt application, seedlings of Triticum turgidum ssp. durum, cv. Cappelli were treated for 2 and 7 days with salt in the root-zone (0, 50 and 200 mM NaCl) or with salt spray (400 mM NaCl + 0 or 200 mM NaCl in the root-zone). Seedlings accumulated Na+ in their leaves and therefore part of their ability to tolerate high salinity seems to be due to Na+ leaf tissue tolerance. Durum wheat, confirmed as a partially tolerant plant, shows a higher damage under airborne salinity, when both an increase in TBA-reactive material (indicative of lipid peroxidation) and a decrease in root growth were recorded. A different antioxidant response was activated, depending on the type of salt supply. Salt treatment induced a depletion of the reducing power of both ascorbate and glutathione while the highest contents of proline were detected under salt spray conditions. In the short term catalase and ascorbate peroxidase co-operated with glutathione peroxidase in the scavenging of hydrogen peroxide, in particular in salt spray-treated plants. From our data, the durum wheat cultivar Cappelli seems to be sensitive to airborne salinity.

  5. Acute mixed cellular and humoral rejection of renal allograft with leucopenia. (United States)

    Agarwal, D K; Hota, J K; Malhotra, V


    Diagnosis and management of acute renal allograft dysfunction often pose challenge to nephrologists during practice. Acute rejection is a major cause of acute graft dysfunction but is rare in patients with leucopenia. Acute rejection can have either humoral or cellular components or sometimes mixed components. Mixed acute cellular and humoral rejection often present as steroid resistant rejection. Here we report a patient with live related renal transplant recipient with acute graft dysfunction with leucopenia who was found to have mixed acute cellular and humoral rejection.

  6. Towards a paleo-salinity proxy: Decreasing D/H fractionation in algal and bacterial lipids with increasing salinity in Christmas Island saline ponds (United States)

    Sachse, D.; Sachs, J. P.


    We investigated the effect of a wide range of salinities (13 -149 PSU) on the D/H ratio of lipids in microbial mat sediments from hypersaline ponds on Christmas Island. The hydrogen isotope ratios (expressed as δD values) of total lipid extracts, and the individual hydrocarbons heptadecane, heptadecene, octadecane, octadecene, diploptene and phytene from algae and bacteria, became increasingly enriched in deuterium as salinity increased, spanning a range of 100‰ while lake water δD values spanned a range of just 12‰. D/H fractionation between lipids and source water thus decreased as salinity increased. Isotope fractionation factors (αlipid-water) were strongly correlated with salinity and increased in all compound classes studied. The apparent isotope fractionation (ɛlipid-water) decreased by 0.8 to 1.1‰ per PSU increase in salinity. Differences in the hydrogen isotopic composition of lipids derived from three biosynthetic pathways (acetogenic, MVA and DOXP/MEP) remained similar irrespective of the salinity, suggesting that the mechanism responsible for the observed αlipid-water - salinity relationship originates prior to the last common biosynthetic branching point, the Calvin Cycle. These findings imply that caution must be exercised when attempting to reconstruct source water δD values using lipid δD values from aquatic environments that may have experienced salinity variations of ~3 PSU or more (based on a 1‰ per PSU response of D/H fractionation to salinity changes, and a lipid δD measurement precision of 3‰). On the other hand our results can be used to establish a paleo-salinity proxy based on algal and bacterial lipid δD values if salinity variations exceeded ~3 PSU and/or if additional constraints on source water δD values can be made.

  7. Salinity trends in the Ebro River (Spain) (United States)

    Lorenzo-Gonzalez, M.° Angeles; Isidoro, Daniel; Quilez, Dolores


    In the Ebro River Basin (Spain), the increase in water diversion for irrigation (following the increase in irrigated area) and the recovery of natural vegetation in the upper reaches, along with climate change have induced changes in the river flow and its associated salt loads. This study was supported by the Ebro River Basin Administration (CHE) and aimed to establish the trends in the salt concentrations and loads of the Ebro River at Tortosa (no 027, the extreme downstream gauging station). The CHE databases from 1972-73 to 2011-12, including mean monthly flows (Q) and concentration readings (electrical conductivity converted to total dissolved solids -TDS- by regression) from monthly grab samples, have been used. The trends were established by (i) harmonic regression analysis; (ii) linear regression by month; and (iii) the non-parametric Mann-Kendall method. Additionally, (iv) the regressions of TDS on Q in the current and previous months were established, allowing for analyzing separately the trends in TDS linked to- (TDSq) and independent of- (TDSaj) the observed changes in flow. In all cases, the trends were analyzed for different periods within the full span 1973-2012 (1973 to 2012, 1981 to 2012, 1990-2012 and 2001-2012), trying to account for periods with sensibly similar patterns of land use change. An increase in TDS was found for all the periods analyzed that was lower as shorter periods were used, suggesting that lower salinity changes might be taking place in the last years, possibly due to the reduction in the rate of irrigation development and to the on-going irrigation modernization process. The higher seasonal TDS increases were found in autumn and winter months and the increase in TDS was linked both to intrinsic changes in salinity (TDSaj) and to the observed decrease in flow (TDSq). On the other hand, the salt loads decreased, especially in autumn, as a result of the observed flow decrease. These results are based on the observed evolution of

  8. The Aquarius Salinity Retrieval Algorithm: Early Results (United States)

    Meissner, Thomas; Wentz, Frank J.; Lagerloef, Gary; LeVine, David


    The Aquarius L-band radiometer/scatterometer system is designed to provide monthly salinity maps at 150 km spatial scale to a 0.2 psu accuracy. The sensor was launched on June 10, 2011, aboard the Argentine CONAE SAC-D spacecraft. The L-band radiometers and the scatterometer have been taking science data observations since August 25, 2011. The first part of this presentation gives an overview over the Aquarius salinity retrieval algorithm. The instrument calibration converts Aquarius radiometer counts into antenna temperatures (TA). The salinity retrieval algorithm converts those TA into brightness temperatures (TB) at a flat ocean surface. As a first step, contributions arising from the intrusion of solar, lunar and galactic radiation are subtracted. The antenna pattern correction (APC) removes the effects of cross-polarization contamination and spillover. The Aquarius radiometer measures the 3rd Stokes parameter in addition to vertical (v) and horizontal (h) polarizations, which allows for an easy removal of ionospheric Faraday rotation. The atmospheric absorption at L-band is almost entirely due to O2, which can be calculated based on auxiliary input fields from numerical weather prediction models and then successively removed from the TB. The final step in the TA to TB conversion is the correction for the roughness of the sea surface due to wind. This is based on the radar backscatter measurements by the scatterometer. The TB of the flat ocean surface can now be matched to a salinity value using a surface emission model that is based on a model for the dielectric constant of sea water and an auxiliary field for the sea surface temperature. In the current processing (as of writing this abstract) only v-pol TB are used for this last process and NCEP winds are used for the roughness correction. Before the salinity algorithm can be operationally implemented and its accuracy assessed by comparing versus in situ measurements, an extensive calibration and validation

  9. Scrapheap Challenge

    CERN Document Server


    Three British guys at CERN recently took a break from work to try their hand at Scrapheap Challenge. Shown on Channel 4 in the UK, it is a show where two teams must construct a machine for a specific task using only the junk they can scavenge from the scrap yard around them. And they have just 10 hours to build their contraption before it is put to the test. The first round, aired 19 September, pitted a team of three women, from the British Army's Royal Electrical and Mechanical Engineers, against the CERN guys - the Up 'n Atoms: Ali Day, David McFarlane and James Ridewood. Each team, with the help of an appointed expert, had the task of making a giant, 3-metre self-propelled "bowling ball", to roll down a 50 metre bowling alley at skittles 4 metres high. The Up 'n Atoms' contraption featured a small car with a huge wheel on its back. Once up to speed, slamming on the brakes caused the wheel to roll over and take the car with it. On their very last run they managed to take out seven pins. Luckily, though, ...

  10. Plasticity of the systemic inflammatory response to acute infection during critical illness: development of the riboleukogram.

    Directory of Open Access Journals (Sweden)

    Jonathan E McDunn

    Full Text Available BACKGROUND: Diagnosis of acute infection in the critically ill remains a challenge. We hypothesized that circulating leukocyte transcriptional profiles can be used to monitor the host response to and recovery from infection complicating critical illness. METHODOLOGY/PRINCIPAL FINDINGS: A translational research approach was employed. Fifteen mice underwent intratracheal injections of live P. aeruginosa, P. aeruginosa endotoxin, live S. pneumoniae, or normal saline. At 24 hours after injury, GeneChip microarray analysis of circulating buffy coat RNA identified 219 genes that distinguished between the pulmonary insults and differences in 7-day mortality. Similarly, buffy coat microarray expression profiles were generated from 27 mechanically ventilated patients every two days for up to three weeks. Significant heterogeneity of VAP microarray profiles was observed secondary to patient ethnicity, age, and gender, yet 85 genes were identified with consistent changes in abundance during the seven days bracketing the diagnosis of VAP. Principal components analysis of these 85 genes appeared to differentiate between the responses of subjects who did versus those who did not develop VAP, as defined by a general trajectory (riboleukogram for the onset and resolution of VAP. As patients recovered from critical illness complicated by acute infection, the riboleukograms converged, consistent with an immune attractor. CONCLUSIONS/SIGNIFICANCE: Here we present the culmination of a mouse pneumonia study, demonstrating for the first time that disease trajectories derived from microarray expression profiles can be used to quantitatively track the clinical course of acute disease and identify a state of immune recovery. These data suggest that the onset of an infection-specific transcriptional program may precede the clinical diagnosis of pneumonia in patients. Moreover, riboleukograms may help explain variance in the host response due to differences in ethnic

  11. Strategic Assessment 1995. U.S. Security Challenges in Transition (United States)


    indeed, from the North and the East. The Islamic quite the contrary. A recent scholarly re- revival may spread into the Sahel , West view of Africa’s...changing temperature and budget reductions. From the 600 ship Navy salinity , and the radar impact of nearby of 1988, the Navy has been challenged to land

  12. The interaction between tide and salinity barriers

    Directory of Open Access Journals (Sweden)

    Patchanok Srivihok


    Full Text Available Presently, there is a number of salinity barrier utilization and this kind of structure becomes more common in estuarine areas. However, the construction of barrier at the river mouth or inside the river results in amplification of tide due to creation of standing tide at the barrier. This standing tide creates two major problems, namely, the overspill of salinewater during high water and bank erosion during low water along the tidal reach downstream of the barrier. In this study, the analytical model is developed to determine the river hydraulic behaviors which affects by tide, river flow and barrier structure of the Bang Pakong River, Thailand. The analytical model of tide and river flow of the Chao Phraya River is adopted and adjusted to determine the tide characteristics modified by river flow. Moreover, the analytical model of tide and salinity barrier would then be developed by cooperating of the analytical model of tide and river flow interaction together with tidal flow cooscillating tide theory. It is found from this study that the analytical model of the Chao Phraya River which is suitable for high freshwater discharge underestimates damping modulus and friction slope which requires adjustment for low freshwater discharge of the Bang Pakong River. The analytical model of tide and salinity barrier can be finally used to predict the water level downstream of the barrier. The model overestimated the water level fluctuation during the unsteady flow from upstream which may be because of the assumption of steady flow condition in the model development due to limited data available after the construction.

  13. Acute pancreatitis in early postpartum period: A case report

    Directory of Open Access Journals (Sweden)

    Arun Sharma


    Full Text Available Acute pancreatitis (AP during peripartum is a rare life-threatening condition which poses as a real challenge for clinician to diagnose it early. Here, we present a case of severe AP occurring in early postpartum period.

  14. Acute Myopericarditis Mimicking Acute Myocardial Infarction

    Directory of Open Access Journals (Sweden)

    Seval İzdeş


    Full Text Available Acute coronary syndromes among young adults are relatively low when compared with older population in the intensive care unit. Electrocardiographic abnormalities mimicking acute coronary syndromes may be caused by non-coronary syndromes and the differential diagnosis requires a detailed evaluation. We are reporting a case of myopericarditis presenting with acute ST elevation and elevated cardiac enzymes simulating acute coronary syndrome. In this case report, the literature is reviewed to discuss the approach to distinguish an acute coronary syndrome from myopericarditis. (Journal of the Turkish Society Intensive Care 2011; 9:68-70

  15. Acute total sleep deprivation potentiates amphetamine-induced locomotor-stimulant effects and behavioral sensitization in mice. (United States)

    Saito, Luis P; Fukushiro, Daniela F; Hollais, André W; Mári-Kawamoto, Elisa; Costa, Jacqueline M; Berro, Laís F; Aramini, Tatiana C F; Wuo-Silva, Raphael; Andersen, Monica L; Tufik, Sergio; Frussa-Filho, Roberto


    It has been demonstrated that a prolonged period (48 h) of paradoxical sleep deprivation (PSD) potentiates amphetamine (AMP)-induced behavioral sensitization, an animal model of addiction-related neuroadaptations. In the present study, we examined the effects of an acute short-term deprivation of total sleep (TSD) (6h) on AMP-induced behavioral sensitization in mice and compared them to the effects of short-term PSD (6 h). Three-month-old male C57BL/6J mice underwent TSD (experiment 1-gentle handling method) or PSD (experiment 2-multiple platforms method) for 6 h. Immediately after the sleep deprivation period, mice were tested in the open field for 10 min under the effects of saline or 2.0 mg/kg AMP. Seven days later, to assess behavioral sensitization, all of the mice received a challenge injection of 2.0 mg/kg AMP and were tested in the open field for 10 min. Total, peripheral, and central locomotion, and grooming duration were measured. TSD, but not PSD, potentiated the hyperlocomotion induced by an acute injection of AMP and this effect was due to an increased locomotion in the central squares of the apparatus. Similarly, TSD facilitated the development of AMP-induced sensitization, but only in the central locomotion parameter. The data indicate that an acute period of TSD may exacerbate the behavioral effects of AMP in mice. Because sleep architecture is composed of paradoxical and slow wave sleep, and 6-h PSD had no effects on AMP-induced hyperlocomotion or sensitization, our data suggest that the deprivation of slow wave sleep plays a critical role in the mechanisms that underlie the potentiating effects of TSD on both the acute and sensitized addiction-related responses to AMP.

  16. Integrating water by plant roots over spatially distributed soil salinity (United States)

    Homaee, Mehdi; Schmidhalter, Urs


    In numerical simulation models dealing with water movement and solute transport in vadose zone, the water budget largely depends on uptake patterns by plant roots. In real field conditions, the uptake pattern largely changes in time and space. When dealing with soil and water salinity, most saline soils demonstrate spatially distributed osmotic head over the root zone. In order to quantify such processes, the major difficulty stems from lacking a sink term function that adequately accounts for the extraction term especially under variable soil water osmotic heads. The question of how plants integrate such space variable over its rooting depth remains as interesting issue for investigators. To move one step forward towards countering this concern, a well equipped experiment was conducted under heterogeneously distributed salinity over the root zone with alfalfa. The extraction rates of soil increments were calculated with the one dimensional form of Richards equation. The results indicated that the plant uptake rate under different mean soil salinities preliminary reacts to soil salinity, whereas at given water content and salinity the "evaporative demand" and "root activity" become more important to control the uptake patterns. Further analysis revealed that root activity is inconstant when imposed to variable soil salinity. It can be concluded that under heterogeneously distributed salinity, most water is taken from the less saline increment while the extraction from other root zone increments with higher salinities never stops.

  17. Saline dust storms and their ecological impacts in arid regions

    Institute of Scientific and Technical Information of China (English)

    Jilili; Abuduwaili


    In many arid and semiarid regions,saline playas represent a significant source of unconsoli-dated sediments available for aeolian transport,and severe saline dust storms occur frequently due to human disturbance.In this study,saline dust storms are reviewed systematically from the aspects of con-cept,general characteristics,conditions of occurrence,distribution and ecological impact.Our researches showed that saline dust storms are a kind of chemical dust storm originating in dry lake beds in arid and semiarid regions;large areas of unconsolidated saline playa sediments and frequent strong winds are the basic factors to saline dust storm occurrence;there are differentiation characteristics in deposition flux and chemical composition with wind-blown distance during saline dust storm diffusion;and saline dust storm diffusion to some extent increases glacier melt and results in soil salinization in arid regions.An under-standing of saline dust storms is important to guide disaster prevention and ecological rehabilitation.

  18. Regulatory challenges

    Energy Technology Data Exchange (ETDEWEB)

    Austvik, Ole Gunnar


    The problem for policy makers wanting to liberalize natural gas markets is that its concentrated structure may also be the socially most efficient one. Because of scale economies, more firms operating in the market may incur higher transportation costs unless the market grows sufficiently in each geographic segment. This argument goes for product extension through vertical (or horizontal) integration and the exploitation of economies of scope as well. Thus, the challenge for governments is to intervene in a way that preserves a market structure that has the potential to minimize cost, and at the same lime change its behavior in order to avoid possible lax cost control and exploitation of market power. The existence of scope advantages indicates that liberalization of the market should open for the possibility to bundle services in competition with provision of unbundled services. If operations are unbundled and there exist economies of scope, the gain from increased competition should be weighed against the losses of less efficient operations of each firm. Thus, with the growth in the European market, gradually more arguments support the idea of unbundling. The significant scale economy in trunk pipelines, sunk investments and capital immobility, possible economies of scope in vertical integration and companies' bundling of services influences vertical and horizontal ownership relations and contractual terms in the European gas market. In specific segments of the markets, these relationships may promote efficient investments and pricing without public interference, but the strong concentration of market power indicates that this is rather the exception than the rule. In order to design an efficient and welfare maximizing way of regulating the market one needs a closer identification of the actual goal of the regulation. Microeconomic theory is often used for this purpose. The author discusses the alternatives of laissez-faire, nationalization or regulation for

  19. Amoebae and Legionella pneumophila in saline environments. (United States)

    Gast, Rebecca J; Moran, Dawn M; Dennett, Mark R; Wurtsbaugh, Wayne A; Amaral-Zettler, Linda A


    Amoeboid protists that harbor bacterial pathogens are of significant interest as potential reservoirs of disease-causing organisms in the environment, but little is known about them in marine and other saline environments. We enriched amoeba cultures from sediments from four sites in the New England estuarine system of Mt. Hope Bay, Massachusetts and from sediments from six sites in the Great Salt Lake, Utah. Cultures of amoebae were enriched using both minimal- and non-nutrient agar plates, made with fresh water, brackish water or saltwater. Recovered amoeba cultures were assayed for the presence of Legionella species using nested polymerase chain reactions (PCR) and primers specific for the genus. Positive samples were then screened with nested amplification using primers specific for the macrophage infectivity potentiator surface protein (mip) gene from L. pneumophila. Forty-eight percent (185 out of 388) of isolated amoeba cultures were positive for the presence of Legionella species. Legionella pneumophila was detected by PCR in 4% of the amoeba cultures (17 out of 388), and most of these amoebae were growing on marine media. Our results show that amoebae capable of growing in saline environments may harbor not only a diverse collection of Legionella species, but also species potentially pathogenic to humans.

  20. Acute otitis externa. (United States)

    Hui, Charles Ps


    Acute otitis externa, also known as 'swimmer's ear', is a common disease of children, adolescents and adults. While chronic suppurative otitis media or acute otitis media with tympanostomy tubes or a perforation can cause acute otitis externa, both the infecting organisms and management protocol are different. This practice point focuses solely on managing acute otitis externa, without acute otitis media, tympanostomy tubes or a perforation being present.

  1. Acute otitis externa



    Acute otitis externa, also known as ‘swimmer’s ear’, is a common disease of children, adolescents and adults. While chronic suppurative otitis media or acute otitis media with tympanostomy tubes or a perforation can cause acute otitis externa, both the infecting organisms and management protocol are different. This practice point focuses solely on managing acute otitis externa, without acute otitis media, tympanostomy tubes or a perforation being present.

  2. SPOT5 imagery for soil salinity assessment in Iraq (United States)

    Teggi, S.; Costanzini, S.; Despini, F.; Chiodi, P.; Immordino, F.


    Soil salinization is a form of topsoil degradation due to the formation of soluble salts at deleterious levels. This phenomenon can seriously compromise vegetation health and agricultural productivity, and represents a worldwide environmental problem. Remote sensing is a very useful tool for soil salinization monitoring and assessment. In this work we show some results of a study aimed to define a methodology for soil salinity assessment in Iraq based on SPOT 5 imagery. This methodology allows the identification of salinized soils primarily on bare soils. Subsequently some soil salinity assessment can be done on vegetated soils. On bare soil the identification of salt is based on spectral analysis, using the Minimum Noise Fraction transformation and several indexes found in literature. In case of densely vegetated soils the methodology for the discrimination of salinized soils has been integrated with the results obtained from the classification of vegetation coverage.




    This paper explores some possible economic impacts of worsening salinity severity and extent in the grains industry across Australia. It also looks at the potential to increase agricultural profits through remediation. The analysis is based on a spatial model of agricultural profits and salinity related crop/pasture yield losses. It is estimated that grains industry farming profits across Australia would rise by an upper limit $138 million per year were salinity costlessly removed from the la...

  4. Salinity adaptation of the invasive New Zealand mud snail (Potamopyrgus antipodarum) in the Columbia River estuary (Pacific Northwest, USA): Physiological and molecular studies (United States)

    Hoy, Marshal; Boese, Bruce L.; Taylor, Louise; Reusser, Deborah; Rodriguez, Rusty


    In this study, we examine salinity stress tolerances of two populations of the invasive species New Zealand mud snail Potamopyrgus antipodarum, one population from a high salinity environment in the Columbia River estuary and the other from a fresh water lake. In 1996, New Zealand mud snails were discovered in the tidal reaches of the Columbia River estuary that is routinely exposed to salinity at near full seawater concentrations. In contrast, in their native habitat and throughout its spread in the western US, New Zealand mud snails are found only in fresh water ecosystems. Our aim was to determine whether the Columbia River snails have become salt water adapted. Using a modification of the standard amphipod sediment toxicity test, salinity tolerance was tested using a range of concentrations up to undiluted seawater, and the snails were sampled for mortality at daily time points. Our results show that the Columbia River snails were more tolerant of acute salinity stress with the LC50 values averaging 38 and 22 Practical Salinity Units for the Columbia River and freshwater snails, respectively. DNA sequence analysis and morphological comparisons of individuals representing each population indicate that they were all P. antipodarum. These results suggest that this species is salt water adaptable and in addition, this investigation helps elucidate the potential of this aquatic invasive organism to adapt to adverse environmental conditions.

  5. High-pressure saline washing of allografts reduces bacterial contamination. (United States)

    Hirn, M Y; Salmela, P M; Vuento, R E


    60 fresh-frozen bone allografts were contaminated on the operating room floor. No bacterial growth was detected in 5 of them after contamination. The remaining 55 grafts had positive bacterial cultures and were processed with three methods: soaking in saline, soaking in antibiotic solution or washing by high-pressure saline. After high-pressure lavage, the cultures were negative in three fourths of the contaminated allografts. The corresponding figures after soaking grafts in saline and antibiotic solution were one tenth and two tenths, respectively. High-pressure saline cleansing of allografts can be recommended because it improves safety by reducing the superficial bacterial bioburden.

  6. Time-dependence of salinity in monsoonal estuaries

    Digital Repository Service at National Institute of Oceanography (India)

    Vijith, V.; Sundar, D.; Shetye, S.R.

    brought by the runoff mixes with the estuarine water and leaves the estuary. Salinity-ingress, which leads to increase of salinity in the estuary, arises from the following processes: horizontal diffusion, gravity current formation and impact of spring... that year. On 10 August 2007, there was hardly any saline water in the estuary (Figure 3(b)), i.e., the estuary was more like a river that day. Two weeks later, on 24 August 2007, following a lull in the rainfall, salinity intruded into the estuary...

  7. Influence of salinity and water content on soil microorganisms

    Directory of Open Access Journals (Sweden)

    Nan Yan


    Full Text Available Salinization is one of the most serious land degradation problems facing world. Salinity results in poor plant growth and low soil microbial activity due to osmotic stress and toxic ions. Soil microorganisms play a pivotal role in soils through mineralization of organic matter into plant available nutrients. Therefore it is important to maintain high microbial activity in soils. Salinity tolerant soil microbes counteract osmotic stress by synthesizing osmolytes which allows them to maintain their cell turgor and metabolism. Osmotic potential is a function of the salt concentration in the soil solution and therefore affected by both salinity (measured as electrical conductivity at a certain water content and soil water content. Soil salinity and water content vary in time and space. Understanding the effect of changes in salinity and water content on soil microorganisms is important for crop production, sustainable land use and rehabilitation of saline soils. In this review, the effects of soil salinity and water content on microbes are discussed to guide future research into management of saline soils.

  8. Salinity inversions in the thermocline under upwelling favorable winds (United States)

    Burchard, Hans; Basdurak, N. Berkay; Gräwe, Ulf; Knoll, Michaela; Mohrholz, Volker; Müller, Selina


    This paper discusses and explains the phenomenon of salinity inversions in the thermocline offshore from an upwelling region during upwelling favorable winds. Using the nontidal central Baltic Sea as an easily accessible natural laboratory, high-resolution transect and station observations in the upper layers are analyzed. The data show local salinity minima in the strongly stratified seasonal thermocline during summer conditions under the influence of upwelling favorable wind. A simple analytical box model using parameters (including variation by means of a Monte Carlo method) estimated from a hindcast model for the Baltic Sea is constructed to explain the observations. As a result, upwelled water with high salinity and low temperature is warmed up due to downward surface heat fluxes while it is transported offshore by the Ekman transport. The warming of upwelled surface water allows maintenance of stable stratification despite the destabilizing salinity stratification, such that local salinity minima in the thermocline can be generated. Inspection of published observations from the Benguela, Peruvian, and eastern tropical North Atlantic upwelling systems shows that also there salinity inversions occur in the thermocline, but in these cases thermocline salinity shows local maxima, since upwelled water has a lower salinity than the surface water. It is hypothesized that thermocline salinity inversions should generally occur offshore from upwelling regions whenever winds are steady enough and surface warming is sufficiently strong.

  9. Differential Expression of Salinity Resistance Gene on Cotton

    Institute of Scientific and Technical Information of China (English)

    YE Wu-wei; YU Shu-xun


    @@ Salinity resistance and differential gene expression associated with salinity in cotton germplasm were studied,because of the large scale area of salinity in China,and its significant negative effects on the cotton production.The salinityresisted genes and their differential expression were studied under the stress of NaCI on cotton.There were found,under the NaCI stress,1644 genes differentially expressed from the salinity-sensitive cotton and only 817 genes differentially expressed from the salinityresisted cotton.

  10. Management of acute myeloid leukemia during pregnancy. (United States)

    Avivi, Irit; Brenner, Benjamin


    Diagnosis of acute leukemia during pregnancy presents significant medical challenges. Pancytopenia, caused by bone marrow substitution with leukemic cells, impairs maternal and fetal health. Chemotherapeutic agents required to be immediately used to save the mother's life are likely to adversely affect fetal development and outcome, especially if administered at an early gestational stage. Patients diagnosed with acute leukemia during the first trimester are, therefore, recommended to undergo pregnancy termination. At later gestational stages, antileukemic therapy can be administered, although in this case, fetal outcome is still associated with increased incidence of growth restriction and loss. Special attention to the issue of future reproduction, adopting a personalized fertility preservation approach, is required. This article addresses these subjects, presenting women diagnosed with acute myeloid and acute promyelocytic leukemia in pregnancy. The rarity of this event, resulting in insufficient data, emphasizes the need for collaborative efforts to optimize management of this complicated clinical condition.

  11. Sensory findings after stimulation of the thoracolumbar fascia with hypertonic saline suggest its contribution to low back pain. (United States)

    Schilder, Andreas; Hoheisel, Ulrich; Magerl, Walter; Benrath, Justus; Klein, Thomas; Treede, Rolf-Detlef


    Injection of hypertonic saline into deep tissues of the back (subcutis, muscle, or the surrounding fascia) can induce acute low back pain (LBP). So far, no study has analyzed differences in temporal, qualitative, and spatial pain characteristics originating from these tissues. The current study aimed to investigate the role of the thoracolumbar fascia as a potential source of LBP. In separate sessions, 12 healthy subjects received ultrasound-guided bolus injections of isotonic saline (0.9%) or hypertonic saline (5.8%) into the erector spinae muscle, the thoracolumbar fascia (posterior layer), and the overlying subcutis. Subjects were asked to rate pain intensity, duration, quality, and spatial extent. Pressure pain thresholds were determined pre and post injection. Injections of hypertonic saline into the fascia resulted in significantly larger area under the curve of pain intensity over time than injections into subcutis (Pfascia or subcutis. Pain radiation and pain affect evoked by fascia injection exceeded those of the muscle (Pfascia injection (burning, throbbing, and stinging) suggested innervation by both A- and C-fiber nociceptors. These findings show that the thoracolumbar fascia is the deep tissue of the back that is most sensitive to chemical stimulation, making it a prime candidate to contribute to nonspecific LBP but not to localized pressure hyperalgesia.

  12. Differences in salinity tolerance and gene expression between two populations of Atlantic cod (Gadus morhua) in response to salinity stress

    DEFF Research Database (Denmark)

    Larsen, Peter Foged; Eg Nielsen, Einar; Meier, Kristian


    in salinity tolerance and gene expression among Atlantic cod (Gadus morhua) from two populations distributed across a steep salinity gradient, we observed high mortality (45% North Sea cod and 80% Baltic Sea cod) in a reciprocal common garden setup. Quantitative RT-PCR assays for expression of hsp70 and Na....... The findings strongly suggest that Atlantic cod are adapted to local saline conditions, despite relatively low levels of neutral genetic divergence between populations...

  13. SMOS salinity in the subtropical North Atlantic salinity maximum. Part II: Two-dimensional horizontal thermohaline variability


    Kolodziejczyk, Nicolas; Hernandez, Olga; Boutin, Jacqueline; Reverdin, Gilles


    International audience; The horizontal thermohaline seasonal variability of the surface ocean is investigated in the subtropical North Atlantic Surface Salinity Maximum (SSSmax) region. Satellite sea surface temperature and salinity are used, along with high-resolution thermosalinograph data, and Argo interpolated products, to study the horizontal two-dimensional field of density and thermohaline variability. During late winter, compensated temperature and salinity gradients at large and meso...

  14. Spatial variability of soil salinity in coastal saline soil at different scales in the Yellow River Delta, China. (United States)

    Wang, Zhuoran; Zhao, Gengxing; Gao, Mingxiu; Chang, Chunyan


    The objectives of this study were to explore the spatial variability of soil salinity in coastal saline soil at macro, meso and micro scales in the Yellow River delta, China. Soil electrical conductivities (ECs) were measured at 0-15, 15-30, 30-45 and 45-60 cm soil depths at 49 sampling sites during November 9 to 11, 2013. Soil salinity was converted from soil ECs based on laboratory analyses. Our results indicated that at the macro scale, soil salinity was high with strong variability in each soil layer, and the content increased and the variability weakened with increasing soil depth. From east to west in the region, the farther away from the sea, the lower the soil salinity was. The degrees of soil salinization in three deeper soil layers are 1.14, 1.24 and 1.40 times higher than that in the surface soil. At the meso scale, the sequence of soil salinity in different topographies, soil texture and vegetation decreased, respectively, as follows: depression >flatland >hillock >batture; sandy loam >light loam >medium loam >heavy loam >clay; bare land >suaeda salsa >reed >cogongrass >cotton >paddy >winter wheat. At the micro scale, soil salinity changed with elevation in natural micro-topography and with anthropogenic activities in cultivated land. As the study area narrowed down to different scales, the spatial variability of soil salinity weakened gradually in cultivated land and salt wasteland except the bare land.

  15. Gulf-Wide Information System, Environmental Sensitivity Index Salinity, Geographic NAD83, LDWF (2001) [esi_salinity_LDWF_2001 (United States)

    Louisiana Geographic Information Center — This data set contains Environmental Sensitivity Index (ESI) salinity data of coastal Louisiana. The ESI is a classification and ranking system, which characterizes...

  16. Paratethys forcing of the Messinian Salinity Crisis (United States)

    Krijgsman, Wout; Van Baak, Christiaan; Flecker, Rachel; Grothe, Arjen; Marzocchi, Alice; Stoica, Marius; Vasiliev, Iuliana


    During the Messinian Salinity Crisis (5.97-5.33 Ma), there is increasing evidence for the presence of fresh water input, not only during the final Lago-mare stage but even during times of evaporite formation. Here we present new strontium isotopic data from two well-dated Messinian sections in the Black and Caspian seas, which show remarkably similar Sr-values as the ones recorded in the Mediterranean during the final phase of the salinity crisis. This strongly suggests that a major fresh water pulse in the Mediterranean originated from the Paratethys. It highlights the importance of a Mediterranean-Black Sea connection during the entire MSC, adding an enormous drainage basin to the Mediterranean water balance. The presence of Paratethyan fauna in the Mediterranean Lago-Mare deposits has fuelled long-lasting controversies over the connectivity between the Mediterranean and Paratethys and contemporary sea level drops in both basins. We furthermore use results of sub-precessional climate simulations to calculate the freshwater budget of the Mediterranean and Paratethys in the Messinian. Using these numerical constraints, we propose a Mediterranean outflow pump as an alternative scenario for the most dramatic hydrological changes in the MSC. This "pump" mechanism significantly enhanced Paratethyan inflow to the Mediterranean, creating 1) suitable conditions for gypsum to form and 2) Lago-mare fauna to migrate and thrive. When the Mediterranean sea level finally reached the height of the Gibraltar sill, Mediterranean outflow restarted there and enhanced exchange with the Atlantic. During this reorganisation of the circulation, brackish and hypersaline waters were pumped out of the Mediterranean, and open marine conditions were re-established without major flooding at the Mio-Pliocene boundary.

  17. Salinity of oceanic hydrothermal fluids: a fluid inclusion study (United States)

    Nehlig, Pierre


    An extensive microthermometric study of quartz, epidote, plagioclase, anhydrite and sphalerite-hosted fluid inclusions from ophiolitic [Semail (Oman) and Trinity (California) ophiolites] and oceanic (East Pacific Rise hydrothermal vents, Gorringe Bank, ODP Leg 111 Hole 504B) crust has been carried out in order to constrain a model accounting for wide salinity variations measured in the oceanic hydrothermal fluids. Recorded salinities in fluid inclusions vary between 0.3 and 52 wt% NaCl eq. However, more than 60% of the mean (± standard deviation) salinities of the samples are within the range 3.2 ± 0.3wt% NaCl eq (= microthermometric error) and the mean salinity of all fluid inclusions (without the brines) is 4.0 wt% NaCl eq with a standard deviation of 1.6 wt% NaCl eq. Whereas most samples display slightly higher salinities than seawater, several samples exhibit very high salinities (more than two times that of seawater). These high salinities are restricted to the plagiogranites (Semail and Trinity ophiolites) which mark the top of the fossil magma chamber, in the transition zone between the plutonic sequence and the sheeted dyke complex. The fluid inclusion population studied in the plagiogranites is characterized by the occurrence of four major fluid inclusion families: (1) low- to medium-salinity Liquid/Vapor fluid inclusions which homogenize into the liquid phase; (2) low-salinity Liquid/Vapor fluid inclusions with pseudocritical homogenization; (3) low- to medium-salinity Liquid/Vapor fluid inclusions which homogenize into the vapor phase; and (4) high-salinity Liquid/Vapor/Halite fluid inclusions which homogenize into the liquid phase by halite dissolution and exhibit salinities as high as 52 wt% NaCl eq. These fluid inclusion families are interpreted as resulting from phase separation occurring in hydrothermal or magmatic fluids within the transition zone between the hydrothermal system and the magma chamber at temperatures higher than 500°C. Very low

  18. Desalination and reuse of high-salinity shale gas produced water: drivers, technologies, and future directions. (United States)

    Shaffer, Devin L; Arias Chavez, Laura H; Ben-Sasson, Moshe; Romero-Vargas Castrillón, Santiago; Yip, Ngai Yin; Elimelech, Menachem


    In the rapidly developing shale gas industry, managing produced water is a major challenge for maintaining the profitability of shale gas extraction while protecting public health and the environment. We review the current state of practice for produced water management across the United States and discuss the interrelated regulatory, infrastructure, and economic drivers for produced water reuse. Within this framework, we examine the Marcellus shale play, a region in the eastern United States where produced water is currently reused without desalination. In the Marcellus region, and in other shale plays worldwide with similar constraints, contraction of current reuse opportunities within the shale gas industry and growing restrictions on produced water disposal will provide strong incentives for produced water desalination for reuse outside the industry. The most challenging scenarios for the selection of desalination for reuse over other management strategies will be those involving high-salinity produced water, which must be desalinated with thermal separation processes. We explore desalination technologies for treatment of high-salinity shale gas produced water, and we critically review mechanical vapor compression (MVC), membrane distillation (MD), and forward osmosis (FO) as the technologies best suited for desalination of high-salinity produced water for reuse outside the shale gas industry. The advantages and challenges of applying MVC, MD, and FO technologies to produced water desalination are discussed, and directions for future research and development are identified. We find that desalination for reuse of produced water is technically feasible and can be economically relevant. However, because produced water management is primarily an economic decision, expanding desalination for reuse is dependent on process and material improvements to reduce capital and operating costs.

  19. Pentoxifylline Treatment in Acute Pancreatitis (AP) (United States)


    Acute Pancreatitis (AP); Gallstone Pancreatitis; Alcoholic Pancreatitis; Post-ERCP/Post-procedural Pancreatitis; Trauma Acute Pancreatitis; Hypertriglyceridemia Acute Pancreatitis; Idiopathic (Unknown) Acute Pancreatitis; Medication Induced Acute Pancreatitis; Cancer Acute Pancreatitis; Miscellaneous (i.e. Acute on Chronic Pancreatitis)

  20. Reduced salinity tolerance in the Arctic grayling (Thymallus arcticus) is associated with rapid development of a gill interlamellar cell mass: implications of high-saline spills on native freshwater salmonids. (United States)

    Blair, Salvatore D; Matheson, Derrick; He, Yuhe; Goss, Greg G


    Arctic grayling (Thymallus arcticus) are salmonids that have a strict freshwater existence in post-glacial North America. Oil and gas development is associated with production of high volumes of hypersaline water. With planned industrial expansion into northern areas of Canada and the USA that directly overlap grayling habitat, the threat of accidental saline water release poses a significant risk. Despite this, we understand little about the responses of grayling to hypersaline waters. We compared the physiological responses and survivability of Arctic grayling and rainbow trout (Oncorhynchus mykiss) to tolerate an acute transfer to higher saline waters. Arctic grayling and rainbow trout were placed directly into 17 ppt salinity and sampled at 24 and 96 h along with control animals in freshwater at 24 h. Serum sodium, chloride and osmolality levels increased significantly in grayling at both 24 and 96 h time points, whereas trout were able to compensate for the osmoregulatory disturbance by 96 h. Sodium-potassium ATPase mRNA expression responses to salinity were also compared, demonstrating the inability of the grayling to up-regulate the seawater isoform nkaα1b. Our results demonstrated a substantially lower salinity tolerance in grayling. We also found a significant salinity-induced morphological gill remodelling by Arctic grayling, as demonstrated by the rapid growth of an interlamellar cell mass by 24 h that persisted at 96 h. We visualized and quantified the appearance of the interlamellar cell mass as a response to high salinity, although the functional significance remains to be understood fully. Compared with rainbow trout, which are used as an environmental regulatory species, Arctic grayling are unable to compensate for the osmotic stressors that would result from a highly saline produced water spill. Given these new data, collaboration between fisheries and the oil and gas industry will be vital in the long-term conservation strategies

  1. Isolation of the combined water content and salinity effects on ERT measurement to locate the preferential flow pathways in water repellent soils (United States)

    Brindt, Naaran; Rahav, Matan; Furman, Alex; Wallach, Rony


    Electrical resistivity tomography (ERT) has been used for measuring the dynamics of water flow in soils without disturbing the soil, and recently for identifying the preferential flow pathways that are reported to develop in water repellent soils. Since electrical resistivity is affected mainly by soil saturation and salinity, and given that in many cases salinity in the root zone reaches high values, the isolation of spatial and temporal distribution of water content or salinity in the root zone from ERT scans is a challenge. A model for transient variation of soil water content and salinity within a well-mixed soil unit was developed in the frame of this challenge. The model aims to isolate the temporal changes in water content from subsequent ERT scans. The model assumes that four stages of water dynamics occur in the root zone during an irrigation cycle: 1) Soil water content decreases by evapotranspiration - no irrigation, 2) Irrigation with saline water begins, water content increases but remains below field capacity - negligible drainage, 3) Irrigation continues and drainage starts as the water content becomes higher than field capacity, and 4) Irrigation stops, water content is higher than field capacity, and water content decreases by drainage and evapotranspiration. These four stages restart when drainage stops and water content decreases solely by evapotranspiration. The model was solved analytically and successfully applied to a series of sequential ERT scans accomplished during and between subsequent irrigation events for a soil that was rendered hydrophobic by olive trees irrigated with saline water, and a soil in a citrus orchard that was rendered hydrophobic by prolonged effluent irrigation. The suggested model helps in distinguishing between the temporal changes in water content and salinity within a given soil volume, locating the preferential plow pathways, and tracking the spatial and temporal salinity variation within the root zone during and

  2. How to diagnose acute appendicitis

    DEFF Research Database (Denmark)

    Mostbeck, Gerhard; Adam, E Jane; Nielsen, Michael Bachmann;


    Acute appendicitis (AA) is a common abdominal emergency with a lifetime prevalence of about 7 %. As the clinical diagnosis of AA remains a challenge to emergency physicians and surgeons, imaging modalities have gained major importance in the diagnostic work-up of patients with suspected AA in order...... appendicitis (AA). • Primary US for AA diagnosis will decrease ionizing radiation and cost. • Sensitivity of US to diagnose AA is lower than of CT/MRI. • Non-visualization of the appendix should lead to clinical reassessment. • Complementary MRI or CT may be performed if diagnosis remains unclear....

  3. Nanosilica and Polyacrylate/Nanosilica: A Comparative Study of Acute Toxicity. (United States)

    Niu, Ying-Mei; Zhu, Xiao-Li; Chang, Bing; Tong, Zhao-Hui; Cao, Wen; Qiao, Pei-Huan; Zhang, Lin-Yuan; Zhao, Jing; Song, Yu-Guo


    We compared the acute toxicity of nanosilica and polyacrylate/nanosilica instillation in Wistar rats (n = 60). Exposure to nanosilica and polyacrylate/nanosilica showed a 30% mortality rate. When compared with saline-treated rats, animals in both exposure groups exhibited a significant reduction of PO2 (P polyacrylate/nanosilica and nanosilica is likely to cause multiple organ toxicity.

  4. Dynamics of rainwater lenses on upward seeping saline groundwater

    NARCIS (Netherlands)

    Eeman, Sara


    Fresh water is generally a limited resource in coastal areas which are often densely populated. In low-lying areas, groundwater is mostly saline and both agriculture and freshwater nature depend on a thin lens of rainwater that is formed by precipitation surplus on top of saline, upward seeping grou

  5. Varietal differences of quinoa’s tolerance to saline conditions

    DEFF Research Database (Denmark)

    Adolf, V I; Shabala, S; Andersen, Mathias Neumann


    Aims This study aimed to assess varietal differences of quinoa’s tolerance to salinity and to investigate physiological mechanisms conferring these differences. Methods Production of biomass in fourteen varieties grown under saline conditions was analysed in a pot experiment. For two contrasting...

  6. Durum wheat and barley productivity in saline-drought environments

    NARCIS (Netherlands)

    Katerji, N.; Mastrorilli, M.; Hoorn, van J.W.; Lahmer, F.Z.; Hamdy, A.; Oweis, T.


    In two Successive years, durum wheat (Triticum turgidum Desf.) and barley (Hodeum vulgare L.) were tested in a factorial salinity-drought experiment, combining three levels of salinity and two levels of drought. The two drought treatments were obtained by applying irrigation water when the pre-dawn

  7. Salinity stress effects changed during Aloe vera L. vegetative growth

    Directory of Open Access Journals (Sweden)

    Jamal-Ali Olfati


    Full Text Available Salt stress is a limiting factor of plant growth and yield, and becoming a serious problem in the world so in reason to determine salinity effect on aloe growth experiment was conducted in a greenhouse as a bi-factorial in completely randomized experimental design with three replications. Aloe plants irrigated with nutrient solution containing different level of NaCl (0, 2, 4, 6 and 8 ms on December and harvesting took place three time with one month interval on January, February and March. Results revealed that salinity affected number of leaf, plant height, number of sprout, root weight, plant weight, leaf weight, total gel weight, and root dry weight. Variance analysis also showed that sampling time relieves significant effect on number of leaf, plant height, and root length, number of sprout, root weight, plant weight, leaf weight and total gel weight. All measured characteristics were highest for control. Interaction between salinity and sampling time on plant height, plant weight, leaf weight and total gel weight showed that these traits decreased in all salinity levels when sampled 30 days after transplanting and the lowest value was related to highest salinity. This result was similar 60 and 90 days after transplanting. Interaction between salinity and sampling time on root length showed that the highest root length was obtained in 2 and 4 ms salinity level when sampled 30 days after transplanting. However all salinity levels also decreased root length 90 days after transplanting.

  8. Towards decadal soil salinity mapping using Landsat time series data (United States)

    Fan, Xingwang; Weng, Yongling; Tao, Jinmei


    Salinization is one of the major soil problems around the world. However, decadal variation in soil salinization has not yet been extensively reported. This study exploited thirty years (1985-2015) of Landsat sensor data, including Landsat-4/5 TM (Thematic Mapper), Landsat-7 ETM+ (Enhanced Thematic Mapper Plus) and Landsat-8 OLI (Operational Land Imager), for monitoring soil salinity of the Yellow River Delta, China. The data were initially corrected for atmospheric effects, and then matched the spectral bands of EO-1 (Earth Observing One) ALI (Advanced Land Imager). Subsequently, soil salinity maps were derived with a previously developed PLSR (Partial Least Square Regression) model. On intra-annual scale, the retrievals showed that soil salinity increased in February, stabilized in March, and decreased in April. On inter-annual scale, soil salinity decreased within 1985-2000 (-0.74 g kg-1/10a, p < 0.001), and increased within 2000-2015 (0.79 g kg-1/10a, p < 0.001). Our study presents a new perspective for use of multiple Landsat data in soil salinity retrieval, and further the understanding of soil salinization development over the Yellow River Delta.

  9. 76 FR 24515 - Colorado River Basin Salinity Control Advisory Council (United States)


    ... Bureau of Reclamation Colorado River Basin Salinity Control Advisory Council AGENCY: Bureau of... Committee Act, the Bureau of Reclamation announces that the Colorado River Basin Salinity Control Advisory...) 524-3826; e-mail at: . SUPPLEMENTARY INFORMATION: The Colorado River Basin...

  10. Coumarin pretreatment alleviates salinity stress in wheat seedlings. (United States)

    Saleh, Ahmed Mahmoud; Madany, M M Y


    The potentiality of COU to improve plant tolerance to salinity was investigated. Wheat grains were primed with COU (50 ppm) and then grown under different levels of NaCl (50, 100, 150 mM) for two weeks. COU pretreatment improved the growth of wheat seedling under salinity, relative to COU-untreated seedlings, due to the accumulation of osmolytes such as soluble sugars and proline. Moreover, COU treatment significantly improved K(+)/Na(+) ratio in the shoots of both salt stressed and un-stressed seedlings. However, in the roots, this ratio increased only under non-salinity. In consistent with phenylalanine ammonia lyase (PAL), phenolics and flavonoids were accumulated in COU-pretreated seedlings under the higher doses of salinity, relative to COU-untreated seedlings. COU primed seedlings showed higher content of the coumarin derivative, scopoletin, and salicylic, chlorogenic, syringic, vanillic, gallic and ferulic acids, under both salinity and non-salinity conditions. Salinity stress significantly improved the activity of peroxidase (POD) in COU-pretreated seedlings. However, the effect of COU on the total antioxidant capacity (TAC) was only obtained at the highest dose of NaCl (150 mM). The present results suggest that COU pretreatment could alleviate the adverse effect of salinity on the growth of wheat seedlings through enhancing, at least partly, the osmoregulation process and antioxidant defense system.

  11. Investigation of Lake Water Salinity by Using Four-Band Salinity Algorithm on WorldView-2 Satellite Image for a Saline Industrial Lake (United States)

    Budakoǧlu, Murat; Karaman, Muhittin; Damla Uça Avcı, Z.; Kumral, Mustafa; Geredeli (Yılmaz), Serpil


    Salinity of a lake is an important characteristic since, these are potentially industrial lakes and the degree of salinity can significantly be used for determination of mineral resources and for the production management. In the literature, there are many studies of using satellite data for salinity related lake studies such as determination of salinity distribution and detection of potential freshwater sources in less salt concentrated regions. As the study area Lake Acigol, located in Denizli (Turkey) was selected. With it's saline environment, it's the major sodium sulphate production resource of Turkey. In this study, remote sensing data and data from a field study was used and correlated. Remote sensing is an efficient tool to monitor and analyze lake properties by using it complementary to field data. Worldview-2 satellite data was used in this study which consists of 8 bands. At the same time with the satellite data acquisition, a field study was conducted to collect the salinity values in 17 points of the laker with using YSI 556 Multiparametre for measurements. The values were measured as salinity amount in grams per kilogram solution and obtained as ppt unit. It was observed that the values vary from 34 ppt - 40.1 ppt and the average is 38.056 ppt. In Thalassic serie, the lake was in mixoeuhaline state in the time of issue. As a first step, ATCOR correction was performed on satellite image for atmospheric correction. There were some clouds on the lake field, hence it was decided to continue the study by using the 12 sampling points which were clear on the image. Then, for each sampling point, a spectral value was obtained by calculating the average at a 11*11 neighborhood. The relation between the spectral reflectance values and the salinity was investigated. The 4-band algorithm, which was used for determination of chlorophyll-a distribution in highly turbid coastal environment by Wei (2012) was applied. Salinity α (Λi-1 / Λj-1) * (Λk-1 / Λm-1) (i

  12. Purification of High Salinity Brine by Multi-Stage Ion Concentration Polarization Desalination (United States)

    Kim, Bumjoo; Kwak, Rhokyun; Kwon, Hyukjin J.; Pham, Van Sang; Kim, Minseok; Al-Anzi, Bader; Lim, Geunbae; Han, Jongyoon


    There is an increasing need for the desalination of high concentration brine (>TDS 35,000 ppm) efficiently and economically, either for the treatment of produced water from shale gas/oil development, or minimizing the environmental impact of brine from existing desalination plants. Yet, reverse osmosis (RO), which is the most widely used for desalination currently, is not practical for brine desalination. This paper demonstrates technical and economic feasibility of ICP (Ion Concentration Polarization) electrical desalination for the high saline water treatment, by adopting multi-stage operation with better energy efficiency. Optimized multi-staging configurations, dependent on the brine salinity values, can be designed based on experimental and numerical analysis. Such an optimization aims at achieving not just the energy efficiency but also (membrane) area efficiency, lowering the true cost of brine treatment. ICP electrical desalination is shown here to treat brine salinity up to 100,000 ppm of Total Dissolved Solids (TDS) with flexible salt rejection rate up to 70% which is promising in a various application treating brine waste. We also demonstrate that ICP desalination has advantage of removing both salts and diverse suspended solids simultaneously, and less susceptibility to membrane fouling/scaling, which is a significant challenge in the membrane processes.

  13. Purification of High Salinity Brine by Multi-Stage Ion Concentration Polarization Desalination. (United States)

    Kim, Bumjoo; Kwak, Rhokyun; Kwon, Hyukjin J; Pham, Van Sang; Kim, Minseok; Al-Anzi, Bader; Lim, Geunbae; Han, Jongyoon


    There is an increasing need for the desalination of high concentration brine (>TDS 35,000 ppm) efficiently and economically, either for the treatment of produced water from shale gas/oil development, or minimizing the environmental impact of brine from existing desalination plants. Yet, reverse osmosis (RO), which is the most widely used for desalination currently, is not practical for brine desalination. This paper demonstrates technical and economic feasibility of ICP (Ion Concentration Polarization) electrical desalination for the high saline water treatment, by adopting multi-stage operation with better energy efficiency. Optimized multi-staging configurations, dependent on the brine salinity values, can be designed based on experimental and numerical analysis. Such an optimization aims at achieving not just the energy efficiency but also (membrane) area efficiency, lowering the true cost of brine treatment. ICP electrical desalination is shown here to treat brine salinity up to 100,000 ppm of Total Dissolved Solids (TDS) with flexible salt rejection rate up to 70% which is promising in a various application treating brine waste. We also demonstrate that ICP desalination has advantage of removing both salts and diverse suspended solids simultaneously, and less susceptibility to membrane fouling/scaling, which is a significant challenge in the membrane processes.

  14. Purification of High Salinity Brine by Multi-Stage Ion Concentration Polarization Desalination (United States)

    Kim, Bumjoo; Kwak, Rhokyun; Kwon, Hyukjin J.; Pham, Van Sang; Kim, Minseok; Al-Anzi, Bader; Lim, Geunbae; Han, Jongyoon


    There is an increasing need for the desalination of high concentration brine (>TDS 35,000 ppm) efficiently and economically, either for the treatment of produced water from shale gas/oil development, or minimizing the environmental impact of brine from existing desalination plants. Yet, reverse osmosis (RO), which is the most widely used for desalination currently, is not practical for brine desalination. This paper demonstrates technical and economic feasibility of ICP (Ion Concentration Polarization) electrical desalination for the high saline water treatment, by adopting multi-stage operation with better energy efficiency. Optimized multi-staging configurations, dependent on the brine salinity values, can be designed based on experimental and numerical analysis. Such an optimization aims at achieving not just the energy efficiency but also (membrane) area efficiency, lowering the true cost of brine treatment. ICP electrical desalination is shown here to treat brine salinity up to 100,000 ppm of Total Dissolved Solids (TDS) with flexible salt rejection rate up to 70% which is promising in a various application treating brine waste. We also demonstrate that ICP desalination has advantage of removing both salts and diverse suspended solids simultaneously, and less susceptibility to membrane fouling/scaling, which is a significant challenge in the membrane processes. PMID:27545955

  15. Hypertonic saline in treatment of pulmonary disease in cystic fibrosis.

    LENUS (Irish Health Repository)

    Reeves, Emer P


    The pathogenesis of lung disease in cystic fibrosis is characterised by decreased airway surface liquid volume and subsequent failure of normal mucociliary clearance. Mucus within the cystic fibrosis airways is enriched in negatively charged matrices composed of DNA released from colonizing bacteria or inflammatory cells, as well as F-actin and elevated concentrations of anionic glycosaminoglycans. Therapies acting against airway mucus in cystic fibrosis include aerosolized hypertonic saline. It has been shown that hypertonic saline possesses mucolytic properties and aids mucociliary clearance by restoring the liquid layer lining the airways. However, recent clinical and bench-top studies are beginning to broaden our view on the beneficial effects of hypertonic saline, which now extend to include anti-infective as well as anti-inflammatory properties. This review aims to discuss the described therapeutic benefits of hypertonic saline and specifically to identify novel models of hypertonic saline action independent of airway hydration.

  16. Hypertonic Saline in Treatment of Pulmonary Disease in Cystic Fibrosis

    Directory of Open Access Journals (Sweden)

    Emer P. Reeves


    Full Text Available The pathogenesis of lung disease in cystic fibrosis is characterised by decreased airway surface liquid volume and subsequent failure of normal mucociliary clearance. Mucus within the cystic fibrosis airways is enriched in negatively charged matrices composed of DNA released from colonizing bacteria or inflammatory cells, as well as F-actin and elevated concentrations of anionic glycosaminoglycans. Therapies acting against airway mucus in cystic fibrosis include aerosolized hypertonic saline. It has been shown that hypertonic saline possesses mucolytic properties and aids mucociliary clearance by restoring the liquid layer lining the airways. However, recent clinical and bench-top studies are beginning to broaden our view on the beneficial effects of hypertonic saline, which now extend to include anti-infective as well as anti-inflammatory properties. This review aims to discuss the described therapeutic benefits of hypertonic saline and specifically to identify novel models of hypertonic saline action independent of airway hydration.

  17. Desalination leading to Salinity Variations in Kuwait Marine Waters

    Directory of Open Access Journals (Sweden)

    Ahmad E. Al-Dousari


    Full Text Available Problem statements: The salinity of seawater is a critical issue for desalination process. Approach: The salinity changes in the coastal waters of Kuwait due to large scale power and desalination activity were evaluated. Results: Systematic sampling campaigns were planned to cover the uptake and outfall of the desalination plant spreading evenly the sampling points to cover the freshwater input zone of Arabian Gulf in north. The salinity observations are critical both for the desalination process and for integrity of the marine environment, which is critical in case of Kuwait. Conclusion/Recommendations: The results showed compliance of Kuwait EPA salinity standard in the area with a difference of around 4 ppt salinity increase at outfall compared to uptake zone.

  18. Histoplasmosis - acute (primary) pulmonary (United States)

    ... this page: // Histoplasmosis - acute (primary) pulmonary To use the sharing features on this page, please enable JavaScript. Acute pulmonary histoplasmosis is a respiratory infection that is caused by ...

  19. Acute respiratory distress syndrome (United States)

    ... page: // Acute respiratory distress syndrome To use the sharing features on this page, please enable JavaScript. Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition that ...

  20. Acute kidney failure (United States)

    Kidney failure; Renal failure; Renal failure - acute; ARF; Kidney injury - acute ... There are many possible causes of kidney damage. They include: ... cholesterol (cholesterol emboli) Decreased blood flow due to very ...

  1. Acute bee paralysis virus [

    Lifescience Database Archive (English)

    Full Text Available Acute bee paralysis virus [gbvrl]: 14 CDS's (15780 codons) fields: [triplet] [frequ...osomal protein / MAP kinase List of codon usage for each CDS (format) Homepage Acute bee paralysis virus ...

  2. Acute Mesenteric Ischemia (United States)

    ... Side Effects Additional Content Medical News Acute Mesenteric Ischemia By Parswa Ansari, MD, Department of Surgery, Lenox ... Abscesses Abdominal Wall Hernias Inguinal Hernia Acute Mesenteric Ischemia Appendicitis Ileus Intestinal Obstruction Ischemic Colitis Perforation of ...

  3. Acute acalculous cholecystitis complicating chemotherapy for acute myeloblastic leukemia


    Olfa Kassar; Feten Kallel; Manel Ghorbel; Hatem. Bellaaj; Zeineb Mnif; Moez Elloumi


    Acute acalculous cholecystitis is a rare complication in the treatment of acute myeloblastic leukemia. Diagnosis of acute acalculous cholecystitis remains difficult during neutropenic period. We present two acute myeloblastic leukemia patients that developed acute acalculous cholecystitis during chemotherapy-induced neutropenia. They suffered from fever, vomiting and acute pain in the epigastrium. Ultrasound demonstrated an acalculous gallbladder. Surgical management was required in one patie...

  4. Genetic variation and plasticity of Plantago coronopus under saline conditions (United States)

    Smekens, Marret J.; van Tienderen, Peter H.


    Phenotypic plasticity may allow organisms to cope with variation in the environmental conditions they encounter in their natural habitats. Salt adaptation appears to be an excellent example of such a plastic response. Many plant species accumulate organic solutes in response to saline conditions. Comparative and molecular studies suggest that this is an adaptation to osmotic stress. However, evidence relating the physiological responses to fitness parameters is rare and requires assessing the potential costs and benefits of plasticity. We studied the response of thirty families derived from plants collected in three populations of Plantago coronopus in a greenhouse experiment under saline and non-saline conditions. We indeed found a positive selection gradient for the sorbitol percentage under saline conditions: plant families with a higher proportion of sorbitol produced more spikes. No effects of sorbitol on fitness parameters were found under non-saline conditions. Populations also differed genetically in leaf number, spike number, sorbitol concentration and percentages of different soluble sugars. Salt treatment led to a reduction of vegetative biomass and spike production but increased leaf dry matter percentage and leaf thickness. Both under saline and non-saline conditions there was a negative trade-off between vegetative growth and reproduction. Families with a high plasticity in leaf thickness had a lower total spike length under non-saline conditions. This would imply that natural selection under predominantly non-saline conditions would lead to a decrease in the ability to change leaf morphology in response to exposure to salt. All other tests revealed no indication for any costs of plasticity to saline conditions.

  5. salinity Budget analysis of of Western Pacific Warm Pool (United States)

    Gao, Shan; nie, xunwei; Qu, Tangdong


    Western pacific warm pool plays an important role in governing global climate variability. In particular, the unique salinity structures of warm pool, barrier layer and salinity front, have significant impacts on the heat content accumulation and zonal migration of warm pool surface water, which further modulate the formation and development of tropical climate phenomenon, such as El Niño, MJO and EAM. In order to have better understanding of how warm pool salinity contributes to climate change the salinity budget of warm pool are investigated using results from a model of the Consortium for Estimating the Circulation and Climate of the Ocean (ECCO). The results show that the salinity budget of warm pool and its components have significant seasonal and annual variability. The surface freshwater flux is the dominant element of salinity budget, which is well balanced by the other ocean dynamic terms. However among all the terms of ocean dynamics, mixing is most significant, whereas advection and entrainment are not dominant, unlike most other region. The further analysis of lagged correlation coefficient between the salinity budget, salinity budget components and NIÑO 3.4 reveals that the salinity budget is highly related to El Niño and Southern Oscillation (ENSO). The results indicate that the annual variability of warm pool salinity budget has a notable correlation coefficient with NIÑO 3.4 (0.7); Mealwhile,variabilities of each components of Ocean dynamics,including diffusion, advection and mixing are found to be highly correlated to ENSO.The local barrier layer is believed to be a major reason.

  6. Geochemical tracers to evaluate hydrogeologic controls on river salinization. (United States)

    Moore, Stephanie J; Bassett, R L; Liu, Beiling; Wolf, Christopher P; Doremus, Dale


    The salinization of rivers, as indicated by salinity increases in the downstream direction, is characteristic of arid and semiarid regions throughout the world. Historically, salinity increases have been attributed to various mechanisms, including (1) evaporation and concentration during reservoir storage, irrigation, and subsequent reuse; (2) displacement of shallow saline ground water during irrigation; (3) erosion and dissolution of natural deposits; and/or (4) inflow of deep saline and/or geothermal ground water (ground water with elevated water temperature). In this study, investigation of salinity issues focused on identification of relative salinity contributions from anthropogenic and natural sources in the Lower Rio Grande in the New Mexico-Texas border region. Based on the conceptual model of the system, the various sources of water and, therefore, salinity to the Lower Rio Grande were identified, and a sampling plan was designed to characterize these sources. Analysis results for boron (delta(11)B), sulfur (delta(34)S), oxygen (delta(18)O), hydrogen (delta(2)H), and strontium ((87)Sr/(86)Sr) isotopes, as well as basic chemical data, confirmed the hypothesis that the dominant salinity contributions are from deep ground water inflow to the Rio Grande. The stable isotopic ratios identified the deep ground water inflow as distinctive, with characteristic isotopic signatures. These analyses indicate that it is not possible to reproduce the observed salinization by evapotranspiration and agricultural processes alone. This investigation further confirms that proper application of multiple isotopic and geochemical tracers can be used to identify and constrain multiple sources of solutes in complex river systems.

  7. A California Winery Wastewater Survey: Assessing the Salinity Challenge for Wastewater Reuse (United States)

    The increasing scarcity of water and tighter regulations for discharge make onsite wastewater reuse an attractive prospect for the California wine industry. This study reports winery wastewater (WW) data from eighteen Northern California (Northern CA) wineries. The current study provides a baseline ...

  8. Modeling and Hemofiltration Treatment of Acute Inflammation

    Directory of Open Access Journals (Sweden)

    Robert S. Parker


    Full Text Available The body responds to endotoxins by triggering the acute inflammatory response system to eliminate the threat posed by gram-negative bacteria (endotoxin and restore health. However, an uncontrolled inflammatory response can lead to tissue damage, organ failure, and ultimately death; this is clinically known as sepsis. Mathematical models of acute inflammatory disease have the potential to guide treatment decisions in critically ill patients. In this work, an 8-state (8-D differential equation model of the acute inflammatory response system to endotoxin challenge was developed. Endotoxin challenges at 3 and 12 mg/kg were administered to rats, and dynamic cytokine data for interleukin (IL-6, tumor necrosis factor (TNF, and IL-10 were obtained and used to calibrate the model. Evaluation of competing model structures was performed by analyzing model predictions at 3, 6, and 12 mg/kg endotoxin challenges with respect to experimental data from rats. Subsequently, a model predictive control (MPC algorithm was synthesized to control a hemoadsorption (HA device, a blood purification treatment for acute inflammation. A particle filter (PF algorithm was implemented to estimate the full state vector of the endotoxemic rat based on time series cytokine measurements. Treatment simulations show that: (i the apparent primary mechanism of HA efficacy is white blood cell (WBC capture, with cytokine capture a secondary benefit; and (ii differential filtering of cytokines and WBC does not provide substantial improvement in treatment outcomes vs. existing HA devices.

  9. Acute mastoiditis in children

    DEFF Research Database (Denmark)

    Anthonsen, Kristian; Høstmark, Karianne; Hansen, Søren;


    Conservative treatment of acute otitis media may lead to more complications. This study evaluates changes in incidence, the clinical and microbiological findings, the complications and the outcome of acute mastoiditis in children in a country employing conservative guidelines in treating acute...... otitis media....

  10. Laparoscopic management of acute appendicitis in situs inversus

    Directory of Open Access Journals (Sweden)

    Golash Vishwanath


    Full Text Available Situs inversus is often detected incidentally in adults during imaging for a acute surgical emergency. We present a case of acute appendicitis in an adult who was previously unaware about his situs anomaly. A laparoscopic approach is helpful to deal with this condition. A 40 year old man was admitted with history of acute left lower abdominal pain, with uncontrolled diabetic keto-acidosis. Clinically, he was diagnosed as acute diverticulitis with localized peritonitis. Subsequent imaging studies and laparoscopy confirmed the diagnosis of situs inversus and acute left- sided appendicitis. He successfully underwent laparoscopic appendectomy. His postoperative recovery was uneventful. Although technically more challenging because of the reverse laparoscopic view of the anatomy, the laparoscopic diagnosis and management of acute appendicitis is indicated in situs inversus.

  11. Diagnostic evaluation of acute pancreatitis in two patients with hypertriglyceridemia

    Institute of Scientific and Technical Information of China (English)

    Yoshifumi Okura; Kozo Hayashi; Tetsuji Shingu; Goro Kajiyama; Yoshiyuki Nakashima; Keijiro Saku


    We present two diagnostically challenging cases of acute pancreatitis with hypertriglyceridemia accompanied with chylomicronemia caused with a deficiency of lipoprotein lipase and with the presence of type V hyperlipidemia.Both cases suffered from acute abdomen following the ingestion of fatty food and revealed the increase in parameters of inflammation without significant elevation of serum amylase levels. The imaging examination of ultrasonography could not detect significant findings of acute pancreatitis and a computer tomography scan eventually confirmed the findings of acute pancreatitis. Both cases responded to a low fat diet and administration of a cholecystokinin receptor antagonist, exhibiting a relief of abdominal symptoms. As in the present cases with acute abdomen following the ingestion of fatty food, the identification of serum hypertriglyceridemia and an abdominal computer tomography scan might be useful in establishing the diagnosis of acute pancreatitis and in developing the therapeutic regimen, when hypertriglyceridemia interferes with the evaluation of pancreatic enzyme activities and ultrasound examination provides poor pancreatic visualization.

  12. Pancreaticoatmospheric fistula following severe acute necrotising pancreatitis. (United States)

    Simoneau, Eve; Chughtai, Talat; Razek, Tarek; Deckelbaum, Dan L


    Severe acute necrotising pancreatitis is associated with numerous local and systemic complications. Abdominal compartment syndrome requiring urgent decompressive laparotomy is a potential complication of this disease process and is associated with increased morbidity and mortality. We describe the case of a pancreaticoatmospheric fistula following decompressive laparotomy in a patient with severe acute necrotising pancreatitis. While this fistula was managed successfully using the current standard of care for pancreatic fistulas, the wound care for in this patient with drainage of the fistula through an open abdomen, is a significant challenge.

  13. Current Concepts in Adult Acute Rhinosinusitis. (United States)

    Aring, Ann M; Chan, Miriam M


    Acute rhinosinusitis is one of the most common conditions that physicians treat in ambulatory care. Most cases of acute rhinosinusitis are caused by viral upper respiratory infections. A meta-analysis based on individual patient data found that common clinical signs and symptoms were not effective for identifying patients with rhinosinusitis who would benefit from antibiotics. C-reactive protein and erythrocyte sedimentation rate are somewhat useful tests for confirming acute bacterial maxillary sinusitis. Four signs and symptoms that significantly increase the likelihood of a bacterial cause when present are double sickening, purulent rhinorrhea, erythrocyte sedimentation rate greater than 10 mm per hour, and purulent secretion in the nasal cavity. Although cutoffs vary depending on the guideline, antibiotic therapy should be considered when rhinosinusitis symptoms fail to improve within seven to 10 days or if they worsen at any time. First-line antibiotics include amoxicillin with or without clavulanate. Current guidelines support watchful waiting within the first seven to 10 days after upper respiratory symptoms first appear. Evidence on the use of analgesics, intranasal corticosteroids, and saline nasal irrigation for the treatment of acute rhinosinusitis is poor. Nonetheless, these therapies may be used to treat symptoms within the first 10 days of upper respiratory infection. Radiography is not recommended in the evaluation of uncomplicated acute rhinosinusitis. For patients who do not respond to treatment, computed tomography of the sinuses without contrast media is helpful to evaluate for possible complications or anatomic abnormalities. Referral to an otolaryngologist is indicated when symptoms persist after maximal medical therapy and if any rare complications are suspected.

  14. Three-dimensional transesophageal echocardiography with agitated saline injection to differentiate between atrial septal defects and echo drop-out artifacts. (United States)

    Alherbish, Aws; Shanks, Miriam; Choy, Jonathan


    The diagnosis of multiple atrial septal defects is less challenging with 3-D transesophageal echocardiography. However, the common occurrence of echo drop-out (acoustic shadow) artifacts with 3-D echocardiography can make the differentiation between a second defect and an artifact challenging. Agitated saline injection with direct visualization using 3-D echocardiography can help resolve this by allowing visualization of the bubbles crossing from true defects.

  15. Plant growth promoting properties of Halobacillus sp. and Halomonas sp. in presence of salinity and heavy metals. (United States)

    Desale, Prithviraj; Patel, Bhargav; Singh, Sukrit; Malhotra, Aakshi; Nawani, Neelu


    Salinity and heavy metal stress are challenging problems in agriculture. Here we report the plant growth promoting ability of three moderate halophiles, Halobacillus sp. ADN1, Halomonas sp. MAN5, and Halobacillus sp. MAN6, in presence of both salinity and heavy metal stress. Halobacillus sp. ADN1, Halomonas sp. MAN5, and Halobacillus sp. MAN6 can tolerate 25, 21, and 29% NaCl, respectively and grow in presence of 1 mM cobalt, cadmium, and nickel and 0.04 mM mercury and 0.03 mM silver. Halobacillus sp. ADN1, Halomonas sp. MAN5, and Halobacillus sp. MAN6 produced 152.5, 95.3, and 167.3 µg/ml indole acetic acid (IAA) and could solubilize 61, 53, and 75 parts per million (ppm) phosphate, respectively in the presence of 15% NaCl. The production of IAA and solubilization of phosphate was well retained in the presence of salinity and heavy metals like 1 mM cadmium, 0.7 mM nickel, 0.04 mM mercury, and 0.03 mM silver. Besides, the strains showed amylase and protease activities and could produce hydrogen cyanide and ammonia in presence of salinity and heavy metals. A mixture of three strains enhanced the root growth of Sesuvium portulacastrum under saline and heavy metal stress, where the root length increased nearly 4.5 ± 0.6 times and root dry weight increased 5.4 ± 0.5 times as compared to control. These strains can thus be useful in microbial assisted phytoremediation of polluted saline soils.

  16. Differential response to soil salinity in endangered key tree cactus: implications for survival in a changing climate. (United States)

    Goodman, Joie; Maschinski, Joyce; Hughes, Phillip; McAuliffe, Joe; Roncal, Julissa; Powell, Devon; Sternberg, Leonel O'reilly


    Understanding reasons for biodiversity loss is essential for developing conservation and management strategies and is becoming increasingly urgent with climate change. Growing at elevations cactus (Pilosocereus robinii) experienced 84 percent loss of total stems from 1994 to 2007. The most severe losses of 99 and 88 percent stems occurred in the largest populations in the Lower Keys, where nine storms with high wind velocities and storm surges, occurred during this period. In contrast, three populations had substantial stem proliferation. To evaluate possible mortality factors related to changes in climate or forest structure, we examined habitat variables: soil salinity, elevation, canopy cover, and habitat structure near 16 dying or dead and 18 living plants growing in the Lower Keys. Soil salinity and elevation were the preliminary factors that discriminated live and dead plants. Soil salinity was 1.5 times greater, but elevation was 12 cm higher near dead plants than near live plants. However, distribution-wide stem loss was not significantly related to salinity or elevation. Controlled salinity trials indicated that salt tolerance to levels above 40 mM NaCl was related to maternal origin. Salt sensitive plants from the Lower Keys had less stem growth, lower root:shoot ratios, lower potassium: sodium ratios and lower recovery rate, but higher δ (13)C than a salt tolerant lineage of unknown origin. Unraveling the genetic structure of salt tolerant and salt sensitive lineages in the Florida Keys will require further genetic tests. Worldwide rare species restricted to fragmented, low-elevation island habitats, with little or no connection to higher ground will face challenges from climate change-related factors. These great conservation challenges will require traditional conservation actions and possibly managed relocation that must be informed by studies such as these.

  17. Imaging of Acute Pancreatitis. (United States)

    Thoeni, Ruedi F


    Acute pancreatitis is an acute inflammation of the pancreas. Several classification systems have been used in the past but were considered unsatisfactory. A revised Atlanta classification of acute pancreatitis was published that assessed the clinical course and severity of disease; divided acute pancreatitis into interstitial edematous pancreatitis and necrotizing pancreatitis; discerned an early phase (first week) from a late phase (after the first week); and focused on systemic inflammatory response syndrome and organ failure. This article focuses on the revised classification of acute pancreatitis, with emphasis on imaging features, particularly on newly-termed fluid collections and implications for the radiologist.

  18. Thank You, Challenges!

    Institute of Scientific and Technical Information of China (English)

    陈晨; 陈传光


    A person may meet many challenges in his or her life.Some people think challenges are terrible.But I think they’re great.And I want to say,"Thank you,challenges!"For some people,it’s hard to face the challenges because they are afraid of failing in the end.However,it’s necessary for a person to face the challenges.Challenges are good to~①you.

  19. Development of Saline Flow Systems in Closed Basins (United States)

    Huntington, J. M.; Halford, K. J.; Garcia, C.


    Saline playas frequently occur in closed basins, such as the Humboldt Salt Marsh in Dixie Valley, in west-central Nevada. This playa is the terminus of a local groundwater flow system, is comprised of dense clay, and has shallow groundwater salinities more than 5 times the salinity of sea water (TDS concentrations of 172,000 to 311,900 mg/L). The saline system has developed and continues to expand as surface runoff and groundwater evaporates from the playa surface and dissolved solutes remain. Negligible discharge of fresh groundwater occurs where the saline system is present, because the fresh-water / saltwater interface that abuts the playa is analogous hydraulically to interfaces in coastal aquifers. The period of time necessary to develop a relatively isolated saline flow system was quantified by simulating a hypothetical cross-section with a variable-density groundwater flow and transport model (SEAWAT). Preliminary analysis suggests that the perimeter of saline system expands between 10 and 100 m every 10,000 years.

  20. Decadal changes in salinity in the oceanic subtropical gyres (United States)

    Melzer, Bryce A.; Subrahmanyam, Bulusu


    We analyzed spatial and temporal salinity trends in five subtropical gyre regions over the past six decades using Simple Ocean Data Assimilation (SODA) reanalysis with a focus on the subsurface salinity of the upper 1000 m of the ocean. Our results indicate an overall salinity increase within the mixed layer, and a salinity decrease at depths greater than 200 m in the global subtropical gyres over 61 years, of which each individual gyre was analyzed in further detail. We determine that freshwater fluxes at the air-sea interface are the primary drivers of the sea surface salinity (SSS) signature over these open ocean regions by quantifying the advective contribution within the surface layer. This was demonstrated through a mixed layer salinity budget in each subtropical gyre based on the vertically integrated advection and entrainment of salt. Our analysis of decadal variability of fluxes into and out of the gyres reveals little change in the strength of the mean currents through this region despite an increase in the annual export of salt in all subtropical gyres, with the meridional component dominating the zonal. This study reveals that the salt content of E-P maximum waters advected into the subtropical gyres is increasing over time. A combination of increasing direct evaporation over the regions with increasing remote evaporation over nearby E-P maxima is believed to be the main driver in increasing salinity of the subtropical oceans, suggesting an intensification of the global water cycle over decadal time scales.

  1. A review of anaerobic treatment of saline wastewater. (United States)

    Xiao, Yeyuan; Roberts, Deborah J


    Large volumes of saline (> 2% w/v NaCl) wastewaters are discharged from many industries; e.g. seafood processing, textile dyeing, oil and gas production, tanneries and drinking water treatment processes. Although anaerobic treatment would be the most cost-effective and sustainable technology for the treatment of many of these saline wastewaters, the salinity is considered to be inhibitory to anaerobic biological treatment processes. The recent applications of salt-tolerant cultures for the treatment of wastewaters from seafood processing and ion-exchange processes suggest that biological systems can be used to treat salty wastewaters. Additionally, organisms capable of anaerobic degradation of contaminants in saline solutions have been observed in marine sediments and have been characterized during the last two decades. This manuscript provides a review of the recent research on anaerobic treatment of saline wastewater and bacterial consortia capable of the anaerobic degradation of pollutants in saline solutions, documenting that the biological treatment of saline wastewaters is promising.

  2. Response of Arctic marine microalgae to changes of salinity

    Institute of Scientific and Technical Information of China (English)


    An algal assemblage collected from the bottom of floe in the Greenland Sea was batchcultured at 1 ± 1℃ and 10 salinity gradients varied from 4.0 to 90.8 for 19 d. The growth for both the algal community and individual populations was characterized by an initial lag phase of six days followed by positive growth. Maximum growth rates were obtained as 0.19/d for the algal community and 0.32 to 0.39 d- 1 for individual populations for the whole experiment period, which mostly occurred at the lower salinities. The competition between the algal species and the evolution of the algal assemblages under the salinity changes was checked. After 14-d culture, the dominating algae in the lower salinities were centric diatoms, pennate diatoms and phytoflagellates, while ones in the higher salinities almost belonged to pennate diatoms. It is suggested that the sea ice algal community from the Greenland Sea prefer lower salinities to higher ones, and the decrease in salinity in small ranges could stimulate the growth of sea ice algae.

  3. Tracking evolution of urban biogeochemical cycles: salinization of fresh water (United States)

    Kaushal, S.; McDowell, W. H.; Wollheim, W. M.; Duan, S.; Gorman, J. K.; Haq, S.; Hohman, S.; Smith, R. M.; Mayer, P. M.


    The built environment often changes quickly in response to human activities, thus contributing to an evolution of stream chemistry over time. Depending upon development and management strategies, these changes can result in pulses and/or long-term trends. Here, we explore patterns of evolving salinization of fresh water over time, and we evaluate the potential water quality implications of fresh water salinization. We show that there has been global salinization of freshwater across urbanizing landscapes over a century. We also show that human-accelerated weathering in watersheds and river alkalinization can further influence regional rates of salinization (in addition to anthropogenic sources such as road salts, sewage leaks, etc.). Finally, we investigate how salinization of fresh water can impact stream sediment fluxes of carbon, nutrients, and sulfate in watersheds across a land use gradient at the Baltimore Long-Term Ecological Research (LTER) site. The impacts of salinization on mobilization and uptake of carbon, nutrients, and sulfate in streams warrant further consideration in water quality management strategies. Overall, we propose that salinization can be a "universal tracer" of watershed urbanization globally with major regional consequences for drinking water and evolution of biogeochemical cycles in freshwater ecosystems.

  4. Comparative study of anticoagulation versus saline flushes in continuous renal replacement therapy

    Directory of Open Access Journals (Sweden)

    Nagarik Amit


    Full Text Available Systemic heparinization during continuous renal replacement therapy (CRRT is associated with disadvantage of risk of bleeding. This study analyses the efficacy of frequent saline flushes compared with heparin anticoagulation to maintain filter life. From January 2004 to November 2007, 65 critically ill patients with acute renal failure underwent CRRT. Continuous venovenous hemodialfiltration (CVVHDF was performed using Diapact Braun CRRT machine. 1.7% P.D. fluid was used as dialysate. 0.9% NS with addition of 10% Ca Gluconate, Magnesium Sulphate, Soda bicarbonate and Potassium Chloride added sequentially in separate units were used for replacement, carefully monitoring their levels. Anticoagulation of extracorporeal circuit was achieved with unfractionated heparin (250-500 units alternate hour in 35 patients targeting aPTT of 45-55 seconds. No anticoagulation was used in 30 patients with baseline APTT > 55 seconds and extracorporeal circuit was maintained with saline flushes at 30 min interval. 65 pa-tients including 42 males. Co-morbidities were comparable in both groups. HMARF was signifi-cantly more common in heparin group while Sepsis was comparable in both the groups. CRRT parameters were similar in both groups. Average filter life in heparin group was 26 ± 6.4 hours while it was 24.5 ± 6.36 hours in heparin free group ( P=NS. Patients receiving heparin had 16 bleeding episodes (0.45/patient while only four bleeding episodes occurred in heparin free group (0.13/patient, P< 0.05. Mortality was 71% in heparin group and 67% in heparin free group. Frequent saline flushes is an effective mode of maintainance of extracorporeal circuit in CRRT when aPTT is already on the higher side, with significantly decreased bleeding episodes.

  5. The role of nitric oxide in saline-induced natriuresis and diuresis in rats. (United States)

    Noonan, W T; Banks, R O


    This study was designed to determine to what extent nitric oxide (NO) mediates the natriuretic and diuretic responses to acute isotonic saline (0.9 gram % NaCl) volume expansion (SVE, 0.5 ml min-1 kg-1). Studies were performed on 49 pentobarbital anesthetized (65 mg/kg) female Sprague-Dawley rats with or without a NO synthase inhibitor, Nomega-nitro-L-arginine (LNA). Group 1 received saline at 27 microliter/min for 1 hr (baseline) and then SVE for 1 hr; Groups 2-4 received LNA at 10, 150, and 200 microgram kg-1 min-1, respectively, for 1 hr followed by LNA + SVE. To determine to what extent inhibition of NOS would reverse an ongoing SVE-induced natriuresis and diuresis, Group 5 was saline-volume-expanded for hours 1 and 2 whereas Group 6 was administered SVE during the first hour and then SVE + 150 microgram kg -1 min-1 LNA during the second hour. SVE caused a significant (P natriuresis or diuresis in these animals). Along these lines, there was a small but significant positive linear correlation coefficient (r = 0.41, P = 0.05) between sodium excretion values and corresponding MAP values in SVE control rats but not in Groups 3-4 during SVE (r = 0.28, P = 0.26). The current data demonstrate that 1) NO does not mediate SVE-induced hyperfiltration in the rat, 2) NO also does not mediate SVE-induced natriuresis or diuresis, and 3), consistent with other reports, NO appears to mediate pressure natriuresis and diuresis.

  6. Ultrasonic Measurements of Unconsolidated Saline Sediments During Freeze/Thaw Cycles: The Seismic Properties of Cryopeg Environments (United States)

    Dou, S.; Ajo Franklin, J. B.


    Saline permafrost and cryopegs (hypersaline unfrozen layers/zones within permafrost) are widespread in the Arctic coastal area as a result of marine transgression and regression in recent geological history. Owing to the freezing-point depression effect of soluble salts, they contain more unfrozen water than non-saline frozen sediments when subjected to the same permafrost temperatures (e.g., from 0 to -15 °C). Mapping subsurface cryopeg structure remains a challenging geophysical task due to the poor penetration of GPR in highly conductive fluids and related limitations for lower frequency EM techniques. Seismic profiling, particularly surface wave characterization, provides one possible approach to delineate the extent of cryopeg bodies. However, interpretation of such surveys is currently limited by the sparse database of measurements examining the seismic properties of unconsolidated materials saturated with saline fluids at sub-zero temperatures. We present the results of experiments examining seismic velocity in the ultrasonic range for both synthetic and natural permafrost sediments during freeze/thaw cycles; in these experiments, use of a range of brine salinities allows us to evaluate the properties of cryopeg sediments at in-situ conditions, a prerequisite for quantitative interpretation of seismic imaging results. Because of the abundant unfrozen water and less developed inter-granular ice structure, the seismic properties of saline permafrost typically falls between frozen and unfrozen soils. We conducted ultrasonic measurements of a freeze-thaw cycle on 20-30 Ottawa sand (grain size 590-840 μm) as well as natural mineral soils from the Barrow Environmental Observatory (BEO) saturated with brines of different salinities (0-2.5 M NaCl). For each salinity, seismic properties were measured using the ultrasonic (~1 MHz) pulse-transmission method in the temperature range from 20 to -30 °C. Similar to sediments saturated with low salinity fluids, seismic

  7. Partial pressure (or fugacity) of carbon dioxide, temperature, salinity and other variables collected from time series and underway - surface observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from the GULF CHALLENGER in the North Atlantic Ocean and Stellwagen Bank National Marine Sanctuary from 2004-05-10 to 2013-08-15 (NODC Accession 0073808) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0073808 includes chemical, meteorological, physical, time series and underway - surface data collected from GULF CHALLENGER in the North Atlantic...

  8. Saline aquifer mapping project in the southeastern United States (United States)

    Williams, Lester J.; Spechler, Rick M.


    In 2009, the U.S. Geological Survey initiated a study of saline aquifers in the southeastern United States to evaluate the potential use of brackish or saline water from the deeper portions of the Floridan aquifer system and the underlying Coastal Plain aquifer system (Fig. 1). The objective of this study is to improve the overall understanding of the available saline water resources for potential future development. Specific tasks are to (1) develop a digital georeferenced database of borehole geophysical data to enable analysis and characterization of saline aquifers (see locations in Fig. 1), (2) identify and map the regional extent of saline aquifer systems and describe the thickness and character of hydrologic units that compose these systems, and (3) delineate salinity variations at key well sites and along section lines to provide a regional depiction of the freshwater-saltwater interfaces. Electrical resistivity and induction logs, coupled with a variety of different porosity logs (sonic, density, and neutron), are the primary types of borehole geophysical logs being used to estimate the water quality in brackish and saline formations. The results from the geophysical log calculations are being compared to available water-quality data obtained from water wells and from drill-stem water samples collected in test wells. Overall, the saline aquifer mapping project is helping to improve the understanding of saline water resources in the area. These aquifers may be sources of large quantities of water that could be treated by using reverse osmosis or similar technologies, or they could be used for aquifer storage and recovery systems.

  9. Acute loss of consciousness. (United States)

    Tristán, Bekinschtein; Gleichgerrcht, Ezequiel; Manes, Facundo


    Acute loss of consciousness poses a fascinating scenario for theoretical and clinical research. This chapter introduces a simple yet powerful framework to investigate altered states of consciousness. We then explore the different disorders of consciousness that result from acute brain injury, and techniques used in the acute phase to predict clinical outcome in different patient populations in light of models of acute loss of consciousness. We further delve into post-traumatic amnesia as a model for predicting cognitive sequels following acute loss of consciousness. We approach the study of acute loss of consciousness from a theoretical and clinical perspective to conclude that clinicians in acute care centers must incorporate new measurements and techniques besides the classic coma scales in order to assess their patients with loss of consciousness.

  10. 0.9% saline is neither normal nor physiological%0.9%盐水既不正常也不生理

    Institute of Scientific and Technical Information of China (English)

    Heng LI; Shi-ren SUN; John Q YAP; Jiang-hua CHEN; Qi QIAN


    folowing saline infusion. Clinically, saline infusion for patients post abdominal and cardiovascular surgery is associated with a greater number of adverse effects including more frequent blood product transfusion and bicarbonate therapy, reduced gastric blood flow, delayed recovery of gut function, impaired cardiac contractility in response to inotropes, prolonged hospital stay, and possibly increased mortality. In critically il patients, saline infusion, compared to balanced fluid infusions, in-creases the occurrence of acute kidney injury. In summary, saline is a highly acidic fluid. With the exception of saline infusion for patients with hypochloremic metabolic alkalosis and volume depletion due to vomiting or upper gastroin-testinal suction, indiscriminate use, especialy for acutely il patients, may cause unnecessary complications and should be avoided. More education regarding saline-related effects and adequate electrolyte management is needed.

  11. Maintenance and broadening of the ocean’s salinity distribution by the water cycle


    Zika, Jan D.; Skliris, Nikolaos; Nurser, A. J. George; Josey, Simon A; Mudryk, Lawrence; Laliberté, Frédéric; Marsh, Robert


    The global water cycle leaves an imprint on ocean salinity through evaporation and precipitation. It has been proposed that observed changes in salinity can be used to infer changes in the water cycle. Here salinity is characterized by the distribution of water masses in salinity coordinates. Only mixing and sources and sinks of freshwater and salt can modify this distribution. Mixing acts to collapse the distribution, making saline waters fresher and fresh waters more saline. Hence, in stead...

  12. The effect of hypertonic saline dextran solutions on hypoxic pulmonary vasoconstriction in anaesthetised piglets. (United States)

    Bellezza, M; Kerbaul, F; Roussel, L; Imbert, M; Guidon, C


    Hypoxic pulmonary vasoconstriction (HPV) is a regulatory mechanism by which blood is diverted from poorly ventilated to better ventilated areas of the lung. The aim of the present study was to assess the extent to which hypertonic saline dextran and dextran solutions modify the magnitude of HPV during isovolumic haemodilution in intact acutely instrumented piglets. Eighteen large white piglets were anesthetised and assigned to two groups. Mean pulmonary arterial pressure (PAP) and cardiac output (Q), systemic arterial pressure and left arterial pressure (LAP) were measured. A decrease in Q was obtained by reducing venous return. This enabled measurement of transpulmonary pressures (mean PAP minus LAP) at four levels of Q in hyperoxia (inspiratory oxygen fraction (FiO2)=0.4) then in hypoxia (Fi,O2=0.1) in the two groups before blood soustraction (10 mL x kg(-1)) and after loading with sodium chloride (NaCl) 7.5% and dextran 6% or with dextran 6% alone. Dextran alone led to a decrease in mean PAP-LAP/Q values, and NaCl with dextran was associated with a significant shift of mean PAP-LAP/Q plots to higher pressures in hypoxia. Hypertonic saline dextran solution, as replacement fluid in isovolaemic haemodilution increased the magnitude of hypoxic pulmonary vasoconstriction, whereas dextran solution reduced it.

  13. Model plant systems in salinity and drought stress proteomics studies: a perspective on Arabidopsis and Sorghum. (United States)

    Ngara, R; Ndimba, B K


    More than a decade after the sequencing of its genome, Arabidopsis still stands as the epitome of a model system in plant biology. Arabidopsis proteomics has also taught us great lessons on different aspects of plant growth, development and physiology. Without doubt our understanding of basic principles of plant biology would not have been this advanced if it were not for knowledge gained using Arabidopsis as a model system. However, with the projections of global climate change and rapid population growth, it is high time we evaluate the applicability of this model system in studies aimed at understanding abiotic stress tolerance and adaptation, with a particular emphasis on maintaining yield under hot and dry environmental conditions. Because of the innate nature of sorghum's tolerance to drought and moderate tolerance to salinity stresses, we believe sorghum is the next logical model system in such studies amongst cereals. In this acute view, we highlight the importance of Arabidopsis as a model system, briefly discuss its potential limitations in drought and salt stress studies, and present our views on the potential usefulness of sorghum as a model system for cereals in drought and salinity stress proteomic studies.

  14. What are the effects of hypertonic saline plus furosemide in acute heart failure?

    Directory of Open Access Journals (Sweden)

    Patricio Zepeda


    Full Text Available En la búsqueda de nuevas terapias para resolver la resistencia a los diuréticos en insuficiencia cardiaca aguda se ha planteado la adición de suero hipertónico. Utilizando la base de datos Epistemonikos, la cual es mantenida mediante búsquedas en 30 bases de datos, identificamos dos revisiones sistemáticas que en conjunto incluyen nueve estudios aleatorizados. Realizamos un metanálisis y tablas de resumen de los resultados utilizando el método GRADE. Se concluye que el suero hipertónico asociado a furosemida probablemente disminuye la mortalidad, estadía y reingreso hospitalario en pacientes con insuficiencia cardiaca descompensada.


    Directory of Open Access Journals (Sweden)

    Akwasi Asamoah


    Full Text Available : Salinization of Ghanaian soils is on the rise. Organic matter application has not proved an effective and feasible technique for curbing this rise. Hence this paper seeks to review techniques that Ghana is using to manage its saline soils and further recommend a feasible, cost effective and beneficial technique for exhaustive research and possible adoption in the future. Halophytes appear to be the most feasible, cost effective and beneficial technique which could be adopted for the effective management of Ghanaian saline soils. But where halophytes are exotic, care must be taken to avoid competition with native species and allow preservation of agrobiodiversity

  16. Remote Sensing of Salinity: The Dielectric Constant of Sea Water (United States)

    LeVine, David M.; Lang, R.; Utku, C.; Tarkocin, Y.


    Global monitoring of sea surface salinity from space requires an accurate model for the dielectric constant of sea water as a function of salinity and temperature to characterize the emissivity of the surface. Measurements are being made at 1.413 GHz, the center frequency of the Aquarius radiometers, using a resonant cavity and the perturbation method. The cavity is operated in a transmission mode and immersed in a liquid bath to control temperature. Multiple measurements are made at each temperature and salinity. Error budgets indicate a relative accuracy for both real and imaginary parts of the dielectric constant of about 1%.

  17. Aquarius Salinity Retrieval Algorithm: Final Pre-Launch Version (United States)

    Wentz, Frank J.; Le Vine, David M.


    This document provides the theoretical basis for the Aquarius salinity retrieval algorithm. The inputs to the algorithm are the Aquarius antenna temperature (T(sub A)) measurements along with a number of NCEP operational products and pre-computed tables of space radiation coming from the galaxy and sun. The output is sea-surface salinity and many intermediate variables required for the salinity calculation. This revision of the Algorithm Theoretical Basis Document (ATBD) is intended to be the final pre-launch version.

  18. Aquarius and Remote Sensing of Sea Surface Salinity from Space (United States)

    LeVine, David M.; Lagerloef, G. S. E.; Torrusio, S.


    Aquarius is an L-band radiometer and scatterometer instrument combination designed to map the salinity field at the surface of the ocean from space. The instrument is designed to provide global salinity maps on a monthly basis with a spatial resolution of 150 km and an accuracy of 0.2 psu. The science objective is to monitor the seasonal and interannual variation of the large scale features of the surface salinity field in the open ocean. This data will promote understanding of ocean circulation and its role in the global water cycle and climate.

  19. Decitabine in Treating Children With Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia (United States)


    Childhood Acute Myeloblastic Leukemia With Maturation (M2); Childhood Acute Promyelocytic Leukemia (M3); Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia

  20. Effects of acute inhalation of albuterol on submaximal and maximal VO2 and blood lactate. (United States)

    Fleck, S J; Lucia, A; Storms, W W; Wallach, J M; Vint, P F; Zimmerman, S D


    The acute effects of inhaled albuterol, a selective beta-2 adrenergic agonist, on measures of endurance cycling performance and pulmonary function were assessed in 21 competitive road cyclists. A 5 step methacholine challenge revealed all cyclists to be non-asthmatic. Albuterol (A) total dose 360 micrograms or a saline placebo (P) was administered by inhaler, in 4 metered doses of 90 micrograms each, 15 minutes before cycle ergometry exercise. Heart rate, whole blood lactate, perceived exertion and VO2 were determined at the submaximal workloads of 150, 200, 225, 250, 275, 300 watts and at max. Pulmonary function tests determining forced vital capacity, forced expiratory volume during the first second of expiration, forced mid-expiratory flow and maximal voluntary ventilation were performed prior to and 10 minutes after inhalation; and 5, 10 and 15 minutes after termination of the exercise protocol. Heart rate was significantly greater during the A compared to the P treatment at 200 (150.8 +/- 2.5 vs 146.7 +/- 2.8 beats per minute), 225 (159.7 +/- 2.4 vs 154.6 +/- 2.7 beats per minute) and 250 watts (166.9 +/- 2.4 vs 164.4 +/- 2.6 beats per minute). Whole blood lactate was significantly greater during the A compared to the P treatment at 275 watts (4.7 +/- 0.3 vs 4.2 +/- 0.4 mmol.l-1). No other significant differences were found between the 2 treatments at any time point. These data indicate that the acute effect of albuterol inhalation at twice the recommended dosage has no positive effect on endurance performance measures or pulmonary function in athletes who are not asthmatic.

  1. Histopathological Sequential Changes in Sodium Taurocholate-Induced Acute Pancreatitis

    Directory of Open Access Journals (Sweden)

    Ashwinikumar Kudari


    Full Text Available Context Experimental models of acute pancreatitis have been developed in order to understand its pathophysiology and extrapancreatic manifestations. Objective The objective of our study was to study sequential changes in the pancreas and distant organs in sodium taurocholate-induced acute pancreatitis in a rat model. Animals Sixteen male Wistar rats weighing 250-300 g. Design The rats were distributed into two groups: induced acute pancreatitis (study group: 8 rats and a control group (8 rats. Within each group, the animals were divided into subgroups: those who were sacrificed early (24 h and 72 h; two each and those who were sacrificed late (120 h and 240 h; two each. Intervention Acute pancreatitis was induced in the rats by multiple intraparenchymal injections of 10% sodium taurocholate solution. In the controls, the same amount of normal saline was injected into the pancreatic parenchyma. Main outcome measures Pathological examination of the pancreas, lungs, kidneys, intestine and liver was done. Results In this model of taurocholate-induced acute pancreatitis, the early changes observed in the pancreas were focal hemorrhages, parenchymal necrosis and neutrophil infiltration. At 72 hours, the changes observed were acinar necrosis, edema, fibrin deposition and inflammatory cell infiltration. Late changes were fibrinoid necrosis and fibroblast proliferation. In the acute phase, the histological changes in the lungs were congestion, focal pulmonary edema and intraalveolar hemorrhages while, in the late stage, there was persistence of vascular congestion. The changes observed in the kidneys were vacuolization of tubular epithelium in the subcapsular region and areas of hemorrhage in the interstitium. Intestinal changes included degenerative changes in the villous epithelium in the acute phase with normalization of the histology in the late phase. Conclusion Our findings correlate with the clinical observation of multisystem organ failure in

  2. Inhibition of Pyk2 blocks lung inflammation and injury in a mouse model of acute lung injury

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    Duan Yingli


    Full Text Available Abstract Background Proline-rich tyrosine kinase 2 (Pyk2 is essential in neutrophil degranulation and chemotaxis in vitro. However, its effect on the process of lung inflammation and edema formation during LPS induced acute lung injury (ALI remains unknown. The goal of the present study was to determine the effect of inhibiting Pyk2 on LPS-induced acute lung inflammation and injury in vivo. Methods C57BL6 mice were given either 10 mg/kg LPS or saline intratracheally. Inhibition of Pyk2 was effected by intraperitoneal administration TAT-Pyk2-CT 1 h before challenge. Bronchoalveolar lavage analysis of cell counts, lung histology and protein concentration in BAL were analyzed at 18 h after LPS treatment. KC and MIP-2 concentrations in BAL were measured by a mouse cytokine multiplex kit. The static lung compliance was determined by pressure-volume curve using a computer-controlled small animal ventilator. The extravasated Evans blue concentration in lung homogenate was determined spectrophotometrically. Results Intratracheal instillation of LPS induced significant neutrophil infiltration into the lung interstitium and alveolar space, which was attenuated by pre-treatment with TAT-Pyk2-CT. TAT-Pyk2-CT pretreatment also attenuated 1 myeloperoxidase content in lung tissues, 2 vascular leakage as measured by Evans blue dye extravasation in the lungs and the increase in protein concentration in bronchoalveolar lavage, and 3 the decrease in lung compliance. In each paradigm, treatment with control protein TAT-GFP had no blocking effect. By contrast, production of neutrophil chemokines MIP-2 and keratinocyte-derived chemokine in the bronchoalveolar lavage was not reduced by TAT-Pyk2-CT. Western blot analysis confirmed that tyrosine phosphorylation of Pyk2 in LPS-challenged lungs was reduced to control levels by TAT-Pyk2-CT pretreatment. Conclusions These results suggest that Pyk2 plays an important role in the development of acute lung injury in mice and

  3. Challenges in secondary prevention after acute myocardial infarction

    DEFF Research Database (Denmark)

    Piepoli, Massimo F; Corrà, Ugo; Dendale, Paul


    Worldwide, each year more than 7 million people experience myocardial infarction, in which one-year mortality rates are now in the range of 10%, but vary with patient characteristics. The consequences are even more dramatic: among patients who survive, 20% suffer a second cardiovascular event...... in the first year and approximately 50% of major coronary events occur in those with a previous hospital discharge diagnosis of ischaemic heart disease.The people behind these numbers spur this call for action. Prevention after myocardial infarction is crucial to reduce risk and suffering. Evidence...

  4. Acute pancreatitis in acute viral hepatitis

    Institute of Scientific and Technical Information of China (English)


    AIM: To elucidate the frequency and characteristics of pancreatic involvement in the course of acute (nonfulminant) viral hepatitis.METHODS: We prospectively assessed the pancreatic involvement in patients with acute viral hepatitis who presented with severe abdomimanl pain.RESULTS: We studied 124 patients with acute viral hepatitis, of whom 24 presented with severe abdominal pain. Seven patients (5.65%) were diagnosed to have acute pancreatitis. All were young males. Five patients had pancreatitis in the first week and two in the fourth week after the onset of jaundice. The pancreatitis was mild and all had uneventful recovery from both pancreatitis and hepatitis on conservative treatment.The etiology of pancreatitis was hepatitis E virus in 4,hepatitis A virus in 2, and hepatitis B virus in 1 patient.One patient had biliary sludge along with HEV infection.The abdominal pain of remaining seventeen patients was attributed to stretching of Glisson's capsule.CONCLUSION: Acute pancreatitis occurs in 5.65% of patients with acute viral hepatitis, it is mild and recovers with conservative management.

  5. Acute otitis media and acute bacterial sinusitis. (United States)

    Wald, Ellen R


    Acute otitis media and acute bacterial sinusitis are 2 of the most common indications for antimicrobial agents in children. Together, they are responsible for billions of dollars of health care expenditures. The pathogenesis of the 2 conditions is identical. In the majority of children with each condition, a preceding viral upper respiratory tract infection predisposes to the development of the acute bacterial complication. It has been shown that viral upper respiratory tract infection predisposes to the development of acute otitis media in 37% of cases. Currently, precise microbiologic diagnosis of acute otitis media and acute bacterial sinusitis requires performance of tympanocentesis in the former and sinus aspiration in the latter. The identification of a virus from the nasopharynx in either case does not obviate the need for antimicrobial therapy. Furthermore, nasal and nasopharyngeal swabs are not useful in predicting the results of culture of the middle ear or paranasal sinus. However, it is possible that a combination of information regarding nasopharyngeal colonization with bacteria and infection with specific viruses may inform treatment decisions in the future.

  6. Acute chylous peritonitis due to acute pancreatitis. (United States)

    Georgiou, Georgios K; Harissis, Haralampos; Mitsis, Michalis; Batsis, Haralampos; Fatouros, Michalis


    We report a case of acute chylous ascites formation presenting as peritonitis (acute chylous peritonitis) in a patient suffering from acute pancreatitis due to hypertriglyceridemia and alcohol abuse. The development of chylous ascites is usually a chronic process mostly involving malignancy, trauma or surgery, and symptoms arise as a result of progressive abdominal distention. However, when accumulation of "chyle" occurs rapidly, the patient may present with signs of peritonitis. Preoperative diagnosis is difficult since the clinical picture usually suggests hollow organ perforation, appendicitis or visceral ischemia. Less than 100 cases of acute chylous peritonitis have been reported. Pancreatitis is a rare cause of chyloperitoneum and in almost all of the cases chylous ascites is discovered some days (or even weeks) after the onset of symptoms of pancreatitis. This is the second case in the literature where the patient presented with acute chylous peritonitis due to acute pancreatitis, and the presence of chyle within the abdominal cavity was discovered simultaneously with the establishment of the diagnosis of pancreatitis. The patient underwent an exploratory laparotomy for suspected perforated duodenal ulcer, since, due to hypertriglyceridemia, serum amylase values appeared within the normal range. Moreover, abdominal computed tomography imaging was not diagnostic for pancreatitis. Following abdominal lavage and drainage, the patient was successfully treated with total parenteral nutrition and octreotide.

  7. Acute chylous peritonitis due to acute pancreatitis

    Institute of Scientific and Technical Information of China (English)

    Georgios K Georgiou; Haralampos Harissis; Michalis Mitsis; Haralampos Batsis; Michalis Fatouros


    We report a case of acute chylous ascites formation presenting as peritonitis (acute chylous peritonitis) in a patient suffering from acute pancreatitis due to hypertriglyceridemia and alcohol abuse.The development of chylous ascites is usually a chronic process mostly involving malignancy,trauma or surgery,and symptoms arise as a result of progressive abdominal distention.However,when accumulation of "chyle" occurs rapidly,the patient may present with signs of peritonitis.Preoperative diagnosis is difficult since the clinical picture usually suggests hollow organ perforation,appendicitis or visceral ischemia.Less than 100 cases of acute chylous peritonitis have been reported.Pancreatitis is a rare cause of chyloperitoneum and in almost all of the cases chylous ascites is discovered some days (or even weeks) after the onset of symptoms of pancreatitis.This is the second case in the literature where the patient presented with acute chylous peritonitis due to acute pancreatitis,and the presence of chyle within the abdominal cavity was discovered simultaneously with the establishment of the diagnosis of pancreatitis.The patient underwent an exploratory laparotomy for suspected perforated duodenal ulcer,since,due to hypertriglyceridemia,serum amylase values appeared within the normal range.Moreover,abdominal computed tomography imaging was not diagnostic for pancreatitis.Following abdominal lavage and drainage,the patient was successfully treated with total parenteral nutrition and octreotide.

  8. Infections may select for filial cannibalism by impacting egg survival in interactions with water salinity and egg density. (United States)

    Lehtonen, Topi K; Kvarnemo, Charlotta


    In aquatic environments, externally developing eggs are in constant contact with the surrounding water, highlighting the significance of water parameters and pathogens for egg survival. In this study we tested the impact of water salinity, egg density and infection potential of the environment on egg viability in the sand goby (Pomatoschistus minutus), a small fish that exhibits paternal egg care and has a marine origin, but which in the Baltic Sea lives in brackish water. To manipulate the infection potential of the environment, we added either a Saprolegnia infection vector into UV-filtered water or a fungicide into natural Baltic Sea water. Saprolegnia are widely spread water moulds that are a key cause of egg mortality in aquatic organisms in fresh- and brackish water. We found that increased water salinity indeed decreased the egg infection rate and had a positive effect on egg viability, while high egg density tended to have the opposite effect. However, the different factors influenced egg viability interactively, with a higher egg density having negative effects at low, but not in high, salinity. Thus, the challenges facing marine organisms adapting to lower salinity levels can be amplified by Saprolegnia infections that reduce egg survival in interaction with other environmental factors. Our results support the hypothesis that suppressing egg infections is an important aspect of parental care that can select for filial cannibalism, a common but poorly understood behaviour, especially in fish with parental care.

  9. Accomplishments of Aquarius: NASA's first global Sea Surface Salinity Mission: a review of the technical findings to date (United States)

    Sen, Amit


    Launched 10 June 2011, the NASA's Aquarius instrument onboard the Argentine built and managed Satélite de Aplicaciones Científicas (SAC-D) has been tirelessly observing the open oceans, confirming and adding new knowledge to the not so vast measured records of our Earth's global oceans. This paper reviews the data collected over the last 3 years, it's findings, challenges and future work that is at hand for the sleepless oceanographers, hydrologists and climate scientists. Although routine data is being collected, a snapshot is presented from almost 3-years of flawless operations showing new discoveries and possibilities of lot more in the future. Repetitive calibration and validation of measurements from Aquarius continue together with comparison of the data to the existing array of Argo temperature/salinity profiling floats, measurements from the recent Salinity Processes in the Upper Ocean Regional Study (SPURS) in-situ experiment and research, and to the data collected from the European Soil Moisture Ocean Salinity (SMOS) mission. This all aids in the optimization of computer model functions to improve the basic understanding of the water cycle over the oceans and its ties to climate. The Aquarius mission operations team also has been tweaking and optimizing algorithms, reprocessing data as needed, and producing salinity movies that has never been seen before. A brief overview of the accomplishments, technical findings to date will be covered in this paper.

  10. NOAA NDBC SOS - sea_water_practical_salinity (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NDBC SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have sea_water_practical_salinity data. Because of the nature of SOS...

  11. Long term Milford Lab Temperature and Salinity Data (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature and salinity of sea water entering the Milford NOAA Laboratory has been being collected since 1948. From 1948-1974 the temperature data was collected at...

  12. Polyamines as salinity biochemical marker in callus of eucalyptus urograndis

    Directory of Open Access Journals (Sweden)

    Giuseppina Lima Pace Pereira


    Full Text Available Biochemical markers have been used for the analysis of plant cells submitted to several types of stress, among them salinity. This work aimed at analyzing the effect of saline stress in callus of Eucalyptus urograndis on polyamine contents. Explants (hypocotyls obtained from seeds were inoculated in callus inductive medium, submitted to different levels of NaCl and analyzed at 10, 20 and 30 days after the inoculation. The free polyamines were extracted, isolated and quantified using TLC (Thin-Layer Chromatography. Putrescine content was higher and a fall in the spermidine content was observed in callus submitted to salinity condition. The results showed that polyamine accumulation is related to NaCl exposure in callus of Eucalyptus urograndis. The decrease in spermine content could be used as a biochemical marker for Eucalyptus callus subjected to salinity.

  13. TAO/TRITON, RAMA, and PIRATA Buoys, Quarterly, Salinity (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has quarterly Salinity data from the TAO/TRITON (Pacific Ocean,, RAMA (Indian Ocean,,...

  14. Salinity on artificial reproduction of silver catfish (Rhamdia quelen

    Directory of Open Access Journals (Sweden)

    Gabriel Bernardes Martins


    Full Text Available Attempting to improve reproduction performance and ichthyo prophylaxis, this study evaluated the effects of maintaining silver catfish (Rhamdia quelen broodstock in different saline concentrations (0, 2, 4, 6 and 8‰ on gametes quality and reproductive viability. The results showed that sperm percent motility did not change between 0 and 4‰, but it was reduced at 6‰, and sperm became immotile at 8‰ salinity. Sperm motility time was increased (almost five fold at 6‰. Salinities up to 4‰ prevented fertilization and hatching, proving their deleterious effects on oocytes and embryos. Therefore, media up to 4‰ salinity may be an alternative for icthyo prophylaxis, although fertilization and incubation must be done in freshwater medium

  15. Reclamation and Management of Saline and Alkali Soils

    DEFF Research Database (Denmark)

    Singh, Anoop; Katiyar, D.; Agrawal, S.B.


    Soil is the most precious natural resource and thus requires proper management. Estimates show that the world as a whole is losing at least 3.0 ha of arable land every minute due to salinization or sodification. In India about 7.0 M ha land is affected by salinity and alkalinity. The problem...... to combat with the problem. The present review is an attempt to emphasize the problem of salinity and alkalinity of soils, its effect on plants and application of physical, chemical and biological methods of soil reclamation along with management issues...... of saline and alkali soils is old but its magnitude and intensity have been increasing because of poor land and water management practices. The proper land management by way of its reclamation involves physical, chemical and biological means, which are site specific and their integration is highly desirable...

  16. Highlights of the First 15 Months of Aquarius Salinity Measurements (United States)

    Lagerloef, Gary S. E.; Kao, Hsun-Ying; Wentz, Frank; LeVine, David M.; Yueh, Simon H.; Feldman, Gene C.


    Aquarius satellite salinity measurements are resolving the major global and regional spatial patterns, and temporal variations, since the start of routine data collection on 25 August 2011. This description includes the principal seasonal variations over the first annual cycle as observed by the mission. In particular, we identify the evolution of low salinity anomalies associated with the Atlantic and Pacific intertropical convergence zones (ITCZ), major river outflows such as the Amazon, a seasonal low salinity anomaly in the Panama bight, and other features. We also explore the links that the salinity variations have with precipitation and surface currents. We then will describe the variations related to the presently evolving 2012 El Nino, now evident, as it progresses through the summer and fall 2012. We conclude with a brief summary of the Aquarius data products and validation

  17. Salinity and Flow Monitoring in the San Francisco Bay Delta (United States)

    This report describes the utility and approximate cost of expanding the salinity water quality monitoring network along the axis of the San Francisco Estuary from Suisun Bay to Rio Vista on the Sacramento River.

  18. Wheat Response to a Soil Previously Irrigated with Saline Water

    Directory of Open Access Journals (Sweden)

    Vito Sardo


    Full Text Available A research was conducted aimed at assessing the response of rainfed, lysimeter-grown wheat to various levels of soil salinity, in terms of dry mass production, inorganic and organic components, sucrose phosphate synthase (SPS and sucrose synthase (SS activity. One additional scope was the assessment of soil ability to recover from applied salts by means of winter precipitations. The results confirmed the relatively high salt tolerance of wheat, as demonstrated by the mechanisms enacted by plants to contrast salinity at root and leaf level. Some insight was gained in the relationships between salinity and the various inorganic and organic components, as well as with SPS and SS activity. It was demonstrated that in a year with precipitations well below the average values (305 mm vs 500 the leaching action of rain was sufficient to eliminate salts accumulated during summer irrigation with saline water.

  19. Acute and chronic pancreatitis: surgical management. (United States)

    Dzakovic, Alexander; Superina, Riccardo


    Pancreatitis is becoming increasingly prevalent in children, posing new challenges to pediatric health care providers. Although some general adult treatment paradigms are applicable in the pediatric population, diagnostic workup and surgical management of acute and chronic pancreatitis have to be tailored to anatomic and pathophysiological entities peculiar to children. Nonbiliary causes of acute pancreatitis in children are generally managed nonoperatively with hydration, close biochemical and clinical observation, and early initiation of enteral feeds. Surgical intervention including cholecystectomy or endoscopic retrograde cholangiopancreatography is often required in acute biliary pancreatitis, whereas infected pancreatic necrosis remains a rare absolute indication for pancreatic debridement and drainage via open, laparoscopic, or interventional radiologic procedure. Chronic pancreatitis is characterized by painful irreversible changes of the parenchyma and ducts, which may result in or be caused by inadequate ductal drainage. A variety of surgical procedures providing drainage, denervation, resection, or a combination thereof are well established to relieve pain and preserve pancreatic function.

  20. Acute rhabdomyolysis following synthetic cannabinoid ingestion

    Directory of Open Access Journals (Sweden)

    Demilade A Adedinsewo


    Full Text Available Context: Novel psychoactive substances, including synthetic cannabinoids, are becoming increasingly popular, with more patients being seen in the emergency room following acute ingestion. These substances have been associated with a wide range of adverse effects. However, identification of complications, clinical toxicity, and management remain challenging. Case Report: We present the case of a young African-American male who developed severe agitation and bizarre behavior following acute K2 ingestion. Laboratory studies revealed markedly elevated serum creatine phosphokinase (CPK with normal renal function. The patient was managed with aggressive intravenous (IV fluid hydration and treatment of underlying psychiatric illness. Conclusion: We recommend the routine evaluation of renal function and CPK levels with early initiation of IV hydration among patients who present to the emergency department following acute ingestion of synthetic cannabinoids to identify potential complications early as well as institute early supportive therapy.

  1. Improving outcomes of acute myocarditis in children. (United States)

    Di Filippo, Sylvie


    Acute viral myocarditis may impair prognosis in children of all ages. Its true incidence is underestimated because of heterogeneity of presentation and outcome. Patients may either recover or progress to chronic cardiomyopathy or death. Improving short-term and long-term prognosis is challenging but can probably be achieved by new diagnostic techniques and novel targeted therapies. The objectives of this review are: (1) to detail the current state of knowledge of the pathophysiological mechanisms of acute myocarditis; (2) to provide an update on diagnostic tools such as magnetic resonance imaging and endomyocardial biopsy; and (3) to present new insights in therapeutic strategies, targeted therapies and management of fulminant cases. Options for improving outcomes in acute myocarditis in the pediatric population are discussed.

  2. Benthic foraminifera cultured over a large salinity gradient: first results and comparison with field data from the Baltic Sea. (United States)

    Groeneveld, Jeroen; Filipsson, Helena L.; Austin, William E. N.; Darling, Kate; Quintana Krupinski, Nadine B.


    Some of the most significant challenges in paleoclimate research arise from the need to both understand and reduce the uncertainty associated with proxy methods for climate reconstructions. This is especially important for shelf and coastal environments where increasing numbers of high-resolution paleorecords are being generated. These challenges are further highlighted in connection with ECORD/IODP Expedition 347: Baltic Sea Paleoenvironments. This large-scale drilling operation took place in the Baltic Sea region during the autumn of 2013. At this time, there is a pressing need for proxy calibrations directly targeted at the brackish Baltic environment. Within the CONTEMPORARY project we are investigating different temperature and salinity proxy variables through a combination of field- and culture-based benthic foraminiferal samples, together with genetic characterization (genotyping) of the morphospecies. We have completed two field campaigns where we collected (living) foraminifera and water samples at several sites, ranging from fully marine to low salinity conditions. The core-top foraminifera have been analysed for trace metal/Ca, stable oxygen and carbon isotopes, and faunal composition. Living foraminifera collected from the sediment-water interface were cultured in sea water in two long-term experiments at different temperatures (5°C and 10°C) and at three different salinities (15, 25, and 35). The first experiment yielded a large number of reproduced and experimentally-grown Elphidium specimens. The second experiment resulted in growth but no reproduction. We will provide a summary of the experimentally grown material and discuss the challenges of generating new proxy calibrations for foraminiferal shell geochemistry in the Baltic Sea. Furthermore, specimens of Elphidium and Ammonia, found at two sampling sites (Anholt, Kattegat and Hanöbay) with differing salinities, were genotyped and the results indicate that the same genotype of Elphidium is

  3. Desertification, salinization, and biotic homogenization in a dryland river ecosystem (United States)

    Miyazono, S.; Patino, Reynaldo; Taylor, C.M.


    This study determined long-term changes in fish assemblages, river discharge, salinity, and local precipitation, and examined hydrological drivers of biotic homogenization in a dryland river ecosystem, the Trans-Pecos region of the Rio Grande/Rio Bravo del Norte (USA/Mexico). Historical (1977-1989) and current (2010-2011) fish assemblages were analyzed by rarefaction analysis (species richness), nonmetric multidimensional scaling (composition/variability), multiresponse permutation procedures (composition), and paired t-test (variability). Trends in hydrological conditions (1970s-2010s) were examined by Kendall tau and quantile regression, and associations between streamfiow and specific conductance (salinity) by generalized linear models. Since the 1970s, species richness and variability of fish assemblages decreased in the Rio Grande below the confluence with the Rio Conchos (Mexico), a major tributary, but not above it. There was increased representation of lower-flow/higher-salinity tolerant species, thus making fish communities below the confluence taxonomically and functionally more homogeneous to those above it. Unlike findings elsewhere, this biotic homogenization was due primarily to changes in the relative abundances of native species. While Rio Conchos discharge was > 2-fold higher than Rio Grande discharge above their confluence, Rio Conchos discharge decreased during the study period causing Rio Grande discharge below the confluence to also decrease. Rio Conchos salinity is lower than Rio Grande salinity above their confluence and, as Rio Conchos discharge decreased, it caused Rio Grande salinity below the confluence to increase (reduced dilution). Trends in discharge did not correspond to trends in precipitation except at extreme-high (90th quantile) levels. In conclusion, decreasing discharge from the Rio Conchos has led to decreasing flow and increasing salinity in the Rio Grande below the confluence. This spatially uneven desertification and

  4. Nonlinear Allometric Equation for Crop Response to Soil Salinity

    Directory of Open Access Journals (Sweden)

    E. Misle


    Full Text Available Crop response to soil salinity has been extensively studied, from empirical works to modelling approach, being described by different equations, first as a piecewise linear model. The equation employed can differ with actual response, causing miscalculation in practical situations, particularly at the higher extremes of the curve. The aim of this work is to propose a new equation, which allows determining the full response to salinity of plant species and to provide a verification using different experimental data sets. A new nonlinear equation is exposed supported by the allometric approach, in which the allometric exponent is salinity-dependent and decreases with the increase in relative salinity. A conversion procedure of parameters of the threshold-slope model is presented; also, a simple procedure for estimating the maximum salinity (zero-yield point when data sets are incomplete is exposed. The equation was tested in a wide range of experimental situations, using data sets from published works, as well as new measurements on seed germination. The statistical indicators of quality (R2, absolute sum of squares and standard deviation of residuals showed that the equation accurately fits the tested empirical results. The new equation for determining crop response to soil salinity is able to follow the response curve of any crop with remarkable accuracy and flexibility. Remarkable characteristics are: a maximum at minimum salinity, a maximum salinity point can be found (zero-yield depending on the data sets, and a meaningful inflection point, as well as the two points at which the slope of the curve equals unity, can be found.

  5. Remote Sensing of Salinity and Overview of Results from Aquarius (United States)

    Le Vine, D. M.; Dinnat, E. P.; Meissner, T.; Wentz, F.; Yueh, S. H.; Lagerloef, G. S. E.


    Aquarius is a combined active/passive microwave (L-band) instrument designed to map the salinity of global oceans from space. The specific goal of Aquarius is to monitor the seasonal and interannual variation of the large scale features of the sea surface salinity (SSS) field of the open ocean (i.e. away from land). The instrumentation has been designed to provide monthly maps with a spatial resolution of 150 km and an accuracy of 0.2 psu

  6. Effect of salinity and calcium on tomato fruit proteome


    Faurobert, Mireille; Valot, Benoit; Bouchet, Jean-Paul; Grasselly, Dominique; Causse, Mathilde,; Ben Ahmed, Hela


    Salinity is a major abiotic stress that adversely affects plant growth and productivity. The physiology of the tomato in salty and nonsalty conditions has been extensively studied, providing an invaluable base to understand the responses of the plants to cultural practices. However few data are yet available at the proteomic level looking for the physiological basis of fruit development, under salt stress. Here, we report the effects of salinity and calcium on fruit proteome variations of two...

  7. Emerging infections: a perpetual challenge. (United States)

    Morens, David M; Folkers, Gregory K; Fauci, Anthony S


    Emerging and re-emerging infectious diseases, and their determinants, have recently attracted substantial scientific and popular attention. HIV/AIDS, severe acute respiratory syndrome, H5N1 avian influenza, and many other emerging diseases have either proved fatal or caused international alarm. Common and interactive co-determinants of disease emergence, including population growth, travel, and environmental disruption, have been increasingly documented and studied. Are emerging infections a new phenomenon related to modern life, or do more basic determinants, transcending time, place, and human progress, govern disease generation? By examining a number of historically notable epidemics, we suggest that emerging diseases, similar in their novelty, impact, and elicitation of control responses, have occurred throughout recorded history. Fundamental determinants, typically acting in concert, seem to underlie their emergence, and infections such as these are likely to continue to remain challenges to human survival.

  8. Role of ascorbic acid and α tocopherol in alleviating salinity stress on flax plant (Linum usitatissimum L.

    Directory of Open Access Journals (Sweden)

    Mervat Sh. Sadak


    Full Text Available Salinity is one of the environmental challenges in the world affecting on several physiological processes and the most limiting factor of plant productivity and quality. Two pot experiments were conducted at the wire house of National Research Centre, Cairo, Egypt during two successive seasons of 2010/2011 and 2011/2012 to assess the efficiency of two antioxidant vitamins (ascorbic acid at 1.13 and 2.27 mM or α tocopherol at 0.46 and 0.93 mM and/or salinity stress at (0.0, 3.08, 6.16, 9.23 ds/m on photosynthetic pigments, protein, carbohydrate, minerals, oil contents and yield as well as fatty acids composition of the yielded oils of three flax cultivars (Sakha 3, Giza 8 and Ariane. The data revealed that salinity stress caused significant and gradual decreases in total photosynthetic pigments, polysaccharides, total carbohydrates, total proteins and the uptake of Mg, K, Ca and P in the leaves of three flax cultivars with increasing salinity levels (3.08, 6.16, 9.23 ds/m. Otherwise, significant and gradual increase appeared in both Na and Cl. Ascorbic acid and α tocopherol at different concentrations caused significant increases in photosynthetic pigments, total carbohydrates and protein contents in the leaves of flax plants irrigated either with tap water or saline solution as compared with their corresponding controls. Exogenous application of ascorbic and α tocopherol at different concentrations exhibited decreases in Na and Cl whereas increases appeared in Mg, K, Ca and P relative to their corresponding control. Ascorbic acid (1.13 and 2.27 mM and α tocopherol (0.46 and 0.93 mM caused marked increases in yield and yield attributes of three flax cultivars either in plants irrigated with tap water or saline solution as compared to corresponding control. Ascorbic acid effects were more pronounced than α tocopherol effects. In addition, the higher level of two vitamins was more pronounced than the lower level. Regarding plants irrigated

  9. Pharm GKB: Leukemia, Nonlymphocytic, Acute [PharmGKB

    Lifescience Database Archive (English)

    Full Text Available Overview Alternate Names: Synonym ANLL; Acute Nonlymphoblastic Leukemia; Acute Nonl...ymphoblastic Leukemias; Acute Nonlymphocytic Leukemia; Acute Nonlymphocytic Leukemias; Leukemia, Acute Nonly...mphoblastic; Leukemia, Acute Nonlymphocytic; Leukemia, Nonlymphoblastic, Acute; Leukemias, Acute Nonlymphoblastic; Leukemias, Acute... Nonlymphocytic; Nonlymphoblastic Leukemia, Acute; Nonlymphoblastic Leukemias, Acut...e; Nonlymphocytic Leukemia, Acute; Nonlymphocytic Leukemias, Acute PharmGKB Accessi

  10. Pharm GKB: Leukemia, Myeloid, Acute [PharmGKB

    Lifescience Database Archive (English)

    Full Text Available Amino Acid Translations are all sourced from dbSNP 144 Overview Alternate Names: Synonym AML - Acute... myeloblastic leukaemia; Acute Myeloblastic Leukemia; Acute Myeloblastic Leukemias; Acute... Myelocytic Leukemia; Acute Myelocytic Leukemias; Acute Myelogenous Leukemia; Acute Myelogenous Leukemias; Acute... granulocytic leukaemia; Acute myeloblastic leukemia; Acute myeloid leukaemia; Acute myeloid leukaemia - category; Acute... myeloid leukaemia, disease; Acute myeloid leukemia; Acute myelo

  11. Dryland salinity in Western Australia: managing a changing water cycle. (United States)

    Taylor, R J; Hoxley, G


    Clearing of agricultural land has resulted in significant changes to the surface and groundwater hydrology. Currently about 10% of agricultural land in Western Australia is affected by dryland salinity and between a quarter and a third of the area is predicted to be lost to salinity before a new hydrological equilibrium is reached. This paper develops a general statement describing the changes to the surface and groundwater hydrology of the wheatbelt of Western Australia between preclearing, the year 2000 and into the future. For typical catchments in the wheatbelt it is estimated that average groundwater recharge and surface runoff have increased about tenfold when comparing the current hydrology to that preclearing. Saline groundwater discharge and flood volumes have also increased significantly. Saline groundwater discharge and associated salt load will probably double in the future in line with the predicted increase in the area of dryland salinity. In addition, future increases in the area of dryland salinity/permanent waterlogging will probably double the volumes in flood events and further increase surface runoff in average years. The outcomes of surface and groundwater management trials have been briefly described to estimate how the hydrology would be modified if the trials were implemented at a catchment scale. These results have been used to formulate possible integrated revegetation and drainage management strategies. The future hydrology and impacts with and without integrated management strategies have been compared.

  12. Annual growth patterns of baldcypress (Taxodium distichum) along salinity gradients (United States)

    Thomas, Brenda L.; Doyle, Thomas W.; Krauss, Ken W.


    The effects of salinity on Taxodium distichum seedlings have been well documented, but few studies have examined mature trees in situ. We investigated the environmental drivers of T. distichum growth along a salinity gradient on the Waccamaw (South Carolina) and Savannah (Georgia) Rivers. On each river, T. distichum increment cores were collected from a healthy upstream site (Upper), a moderately degraded mid-reach site (Middle), and a highly degraded downstream site (Lower). Chronologies were successfully developed for Waccamaw Upper and Middle, and Savannah Middle. Correlations between standardized chronologies and environmental variables showed significant relationships between T. distichum growth and early growing season precipitation, temperature, and Palmer Drought Severity Index (PDSI). Savannah Middle chronology correlated most strongly with August river salinity levels. Both lower sites experienced suppression/release events likely in response to local anthropogenic impacts rather than regional environmental variables. The factors that affect T. distichum growth, including salinity, are strongly synergistic. As sea-level rise pushes the freshwater/saltwater interface inland, salinity becomes more limiting to T. distichum growth in tidal freshwater swamps; however, salinity impacts are exacerbated by locally imposed environmental modifications.

  13. Reclamation of Sodic-Saline Soils. Barley Crop Response

    Directory of Open Access Journals (Sweden)

    Giovanna Cucci


    Full Text Available The research was aimed at assessing the salinity and sodicity effects of two soil types submitted to correction on barley crop. The two soils, contained in cylindrical pots (0.40 m in size and 0.60 m h supplied with a bottom valve for the collection of drainage water and located under shed to prevent the leaching action of rainfall, were clay-textured and saline and sodic-saline at barley seeding, as they had been cultivated for 4 consecutive years with different herbaceous species irrigated with 9 types of brackish water. In 2002-2003 the 2 salinized and sodium-affected soils (ECe and ESP ranging respectively from 5.84-20.27 dSm-1 to 2.83-11.19%, submitted to correction, were cultivated with barley cv Micuccio, and irrigated with fresh water (ECw = 0.5 dS m-1 and SAR = 0.45 whenever 30% of the maximum soil available moisture was lost by evapotranspiration. Barley was shown to be a salt-tolerant species and did not experience any salt stress when grown in soils with an initial ECe up to 11 dS m-1. When it was grown in more saline soils (initial ECe of about 20 dS m-1, despite the correction, it showed a reduction in shoot biomass and kernel yield by 26% and 36% respectively, as compared to less saline soils.

  14. Oil and Protein Accumulation in Soybean Grains under Salinity Stress

    Directory of Open Access Journals (Sweden)



    Full Text Available Two factorial experiments based on randomized complete block design (RCBD with three replications were conducted in 2007 and 2008, to evaluate grain development (four harvests and rate and duration of oil and protein accumulation in three soybean cultivars (�Williams�, �Zan� and �L17� under a non-saline (control and three saline (3, 6 and 9 ds/m NaCl conditions. Six seeds were sown in each pot filled with 900 g perlite, using 144 pots for each experiment. After emergence, seedlings were thinned and 4 plants were kept in each pot. Rate of oil accumulation up to maturity was not significantly affected by salinity. With increasing salinity, rate and percentage of protein accumulation, duration of oil and protein accumulation and oil and protein content per grain decreased, but oil percentage increased. Oil and protein yields per plant decreased as salinity increased. These reductions were mainly attributed to the short duration of protein and oil accumulation and grain yield per plant under saline conditions. �Williams� had the highest rate and duration of protein accumulation and rate of oil accumulation, but �L17� had the highest grain yield per plant. Consequently, differences in protein and oil yields per plant between these two cultivars were not statistically significant. However, �Zan� had the lowest protein and oil yields, due to the lowest grain yield per plant.

  15. Saline Groundwater from Coastal Aquifers As a Source for Desalination. (United States)

    Stein, Shaked; Russak, Amos; Sivan, Orit; Yechieli, Yoseph; Rahav, Eyal; Oren, Yoram; Kasher, Roni


    Reverse osmosis (RO) seawater desalination is currently a widespread means of closing the gap between supply and demand for potable water in arid regions. Currently, one of the main setbacks of RO operation is fouling, which hinders membrane performance and induces pressure loss, thereby reducing system efficiency. An alternative water source is saline groundwater with salinity close to seawater, pumped from beach wells in coastal aquifers which penetrate beneath the freshwater-seawater interface. In this research, we studied the potential use of saline groundwater of the coastal aquifer as feedwater for desalination in comparison to seawater using fieldwork and laboratory approaches. The chemistry, microbiology and physical properties of saline groundwater were characterized and compared with seawater. Additionally, reverse osmosis desalination experiments in a cross-flow system were performed, evaluating the permeate flux, salt rejection and fouling propensities of the different water types. Our results indicated that saline groundwater was significantly favored over seawater as a feed source in terms of chemical composition, microorganism content, silt density, and fouling potential, and exhibited better desalination performance with less flux decline. Saline groundwater may be a better water source for desalination by RO due to lower fouling potential, and reduced pretreatment costs.

  16. Acute bone crises in sickle cell disease: the T1 fat-saturated sequence in differentiation of acute bone infarcts from acute osteomyelitis

    Energy Technology Data Exchange (ETDEWEB)

    Jain, R. [Department of Radiology, College of Medicine, Sultan Qaboos University, Muscat (Oman)], E-mail:; Sawhney, S. [Department of Radiology, College of Medicine, Sultan Qaboos University, Muscat (Oman); Rizvi, S.G. [Department of Community Medicine and Public Health, College of Medicine, Sultan Qaboos University, Muscat (Oman)


    Aim: To prove the hypothesis that acute bone infarcts in sickle cell disease are caused by sequestration of red blood cells (RBCs) in bone marrow, and to evaluate the unenhanced T1 fat-saturated (fs) sequence in the differentiation of acute bone infarction from acute osteomyelitis in patients with sickle-cell disease. Materials and methods: Two studies were undertaken: an experimental study using in-vitro packed red blood cells and normal volunteers, and a retrospective clinical study of 86 magnetic resonance imaging (MRI) studies. For the experimental study containers of packed RBCs were placed between the knees of four healthy volunteers with a saline bag under the containers as an additional control, and were scanned with the pre-contrast T1-fs sequence. Signal intensity (SI) ratios were obtained for packed RBCs:skeletal muscle and packed RBCs:saline. For the clinical study, the SIs of normal bone marrow, packed RBCs, bone and/or soft-tissue lesions, and normal skeletal muscle of 74 patients (86 MRI studies) were measured using unenhanced, T1 fat-saturated MRI. The ratios of the above SIs to normal skeletal muscle were calculated and subjected to statistical analysis. Results: Fifty-one of 86 MRI studies were included in the final analysis. The ratios of SIs for normal bone marrow, packed red cells, bone infarction, acute osteomyelitis, and soft-tissue lesions associated with bone infarct, compared with normal skeletal muscle were (mean {+-} SD) 0.9 {+-} 0.2, 2.1 {+-} 0.7, 1.7 {+-} 0.5, 1.0 {+-} 0.3, and 2.2 {+-} 0.7, respectively. The difference in the ratio of SIs of bone infarcts and osteomyelitis was significant (p = 0.003). The final diagnoses were bone infarction (n = 50), acute osteomyelitis (n = 1), and co-existent bone infarction and osteomyelitis (n = 2). Seven patients who had suspected osteomyelitis underwent image-guided aspiration. Conclusion: Acute bone infarcts in sickle cell disease are caused by sequestration of red blood cells in the bone

  17. [Acute rheumatic fever]. (United States)

    Maier, Alexander; Kommer, Vera


    We report on a young women with acute rheumatic fever. Acute rheumatic fever has become a rare disease in Germany, especially in adults. This carries the risk that it can be missed in the differential diagnostic considerations of acute rheumatic disorders and febrile status. If rheumatic fever is not diagnosed and treated correctly, there is a considerable risk for rheumatic valvular heart disease. In this article diagnosis, differential diagnosis and therapy of rheumatic fever are discussed extensively.

  18. Acute Idiopathic Scrotal Edema

    Directory of Open Access Journals (Sweden)

    Micheál Breen


    Full Text Available We report a case of acute idiopathic scrotal edema (AISE in a 4-year-old boy who presented with acute scrotal pain and erythema. The clinical features, ultrasound appearance, and natural history of this rare diagnosis are reviewed. In this report, we highlight the importance of good ultrasound technique in differentiating the etiology of the acute scrotum and demonstrate the color Doppler “Fountain Sign” that is highly suggestive of AISE.

  19. Saline volume expansion and cardiovascular physiology: novel observations, old explanations, and new questions. (United States)

    Robotham, James L


    In a clinical investigation, Kumar and coworkers reported the hemodynamic events that accompany plasma volume expansion over 3 hours in healthy adult volunteers, and found that increases in stroke volume (SV) may be related to increases in left ventricular (LV)/right ventricular (RV) end-diastolic volume, as they expected, but also to decreases in LV/RV end-systolic volume. The latter finding suggests increased contractility and/or decreased afterload, which do not fit with their perception that clinicians ascribe increases in SV to increases in end-diastolic volume based on Starling's work. Increased ejection fraction and decreased vascular resistances were also observed. The same authors recently reported novel data suggesting that reduced blood viscosity may account for the observed reduction in vascular resistances with saline volume expansion. However, the variances in preload and afterload, along with uncertainty in estimates of contractility, substantially limit their ability to define a primary mechanism to explain decreases in LV end-systolic volume. A focus on using ejection fraction to evaluate the integrated performance of the cardiovascular system is provided to broaden this analytic perspective. Sagawa and colleagues described an approach to estimate the relationship, under clinical conditions, between ventricular and arterial bed elastances (i.e. maximal ventricular systolic elastance [Emax] and maximal arterial systolic elastance [Ea]), reflecting ventricular-arterial coupling. I used the mean data provided in one of the reports from Kumar and coworkers to calculate that LV Emax decreased from 1.09 to 0.96 mmHg/ml with saline volume expansion, while Ea decreased from 1.1 to 0.97 mmHg/ml and the SV increased (i.e. the increase in mean SV was associated with a decrease in mean afterload while the mean contractility decreased). The results reported by Kumar and coworkers invite further studies in normal and critically ill patients during acute saline

  20. Interactive effect of high environmental ammonia and nutritional status on ecophysiological performance of European sea bass (Dicentrarchus labrax) acclimated to reduced seawater salinities


    Sinha, A.K.; Rasoloniriana, R.; Dasan, A.F.; Pipralia, N.; R. Blust; De Boeck, G.


    We investigated the interactive effect of ammonia toxicity, salinity challenge and nutritional status on the ecophysiological performance of European sea bass (Dicentrarchus labrax). Fish were progressively acclimated to normal seawater (32 ppt), to brackish water (20 ppt and 10 ppt) and to hyposaline water (2.5 ppt). Following acclimation to different salinities for two weeks, fish were exposed to high environmental ammonia (HEA, 20 mg/L ~1.18 mM representing 50% of 96 h LC50 value for ammon...

  1. Pharm GKB: Kidney Failure, Acute [PharmGKB

    Lifescience Database Archive (English)

    Full Text Available iew Alternate Names: Synonym ARF - Acute renal failure; Acute Kidney Failure; Acute Kidney Failures; Acute K...idney Insufficiencies; Acute Kidney Insufficiency; Acute Renal Failure; Acute Renal Failures; Acute... Renal Insufficiencies; Acute Renal Insufficiency; Acute renal failure syndrome, NOS; Failure, Acute... Kidney; Failure, Acute Renal; Failures, Acute Kidney; Failures, Acute Renal; Insufficiencies, Acute... Kidney; Insufficiencies, Acute Renal; Insufficiency, Acute Kidney; Insufficiency, Acute

  2. Cyclic use of saline and non-saline water to increase water use efficiency and soil sustainability on drip irrigated maize in a semi-arid region


    Mohammad Hassanli; Hamed Ebrahimian


    Use of saline water for irrigation is a strategy to mitigate water shortage. The objective of this study was to investigate the impact of the cyclic and constant use of saline and non-saline water on drip irrigated maize yield and irrigation water use efficiency (IWUE). Nine field treatments were laid out based on alternative irrigation management of non-saline and saline water combinations. The treatments were: two salinity levels of 3.5 and 5.7 dS/m and freshwater (0.4 dS/m) application in ...

  3. Mixed phenotype acute leukemia

    Institute of Scientific and Technical Information of China (English)

    Ye Zixing; Wang Shujie


    Objective To highlight the current understanding of mixed phenotype acute leukemia (MPAL).Data sources We collected the relevant articles in PubMed (from 1985 to present),using the terms "mixed phenotype acute leukemia","hybrid acute leukemia","biphenotypic acute leukemia",and "mixed lineage leukemia".We also collected the relevant studies in WanFang Data base (from 2000 to present),using the terms "mixed phenotype acute leukemia" and "hybrid acute leukemia".Study selection We included all relevant studies concerning mixed phenotype acute leukemia in English and Chinese version,with no limitation of research design.The duplicated articles are excluded.Results MPAL is a rare subgroup of acute leukemia which expresses the myeloid and lymphoid markers simultaneously.The clinical manifestations of MPAL are similar to other acute leukemias.The World Health Organization classification and the European Group for Immunological classification of Leukaemias 1998 cdteria are most widely used.MPAL does not have a standard therapy regimen.Its treatment depends mostly on the patient's unique immunophenotypic and cytogenetic features,and also the experience of individual physician.The lack of effective treatment contributes to an undesirable prognosis.Conclusion Our understanding about MPAL is still limited.The diagnostic criteria have not been unified.The treatment of MPAL remains to be investigated.The prognostic factor is largely unclear yet.A better diagnostic cdteria and targeted therapeutics will improve the therapy effect and a subsequently better prognosis.

  4. Radiocontrast-induced acute renal failure. (United States)

    Weisbord, Steven D; Palevsky, Paul M


    The intravascular administration of iodinated radiocontrast media can lead to acute renal dysfunction. Even small changes in renal function have been associated with increased morbidity and mortality, making the prevention of radiocontrast nephropathy of paramount importance. This review summarizes the principal risk factors for radiocontrast nephropathy and evidence-based preventive strategies that should be used to limit its occurrence. Risk factors for radiocontrast nephropathy include preexistent kidney disease, diabetes mellitus, dose of radiocontrast used, advanced congestive heart failure, and intravascular volume depletion. Proven preventive measures include volume expansion with intravenous saline or sodium bicarbonate and the use of low-osmolar or iso-osmolar radiocontrast media. Studies evaluating N-acetylcysteine have been conflicting, with meta-analyses suggesting a small beneficial effect. Studies of other pharmacologic agents have not demonstrated clinical benefit.

  5. Intravenous pyridoxine in acute ethanol intoxication. (United States)

    Mardel, S; Phair, I; O'Dwyer, F; Henry, J A


    Intravenous pyridoxine was evaluated as an agent for the reversal of ethanol-induced central nervous depression in a randomised double blind controlled study of 108 patients presenting with a clinical diagnosis of acute ethanol intoxication to two accident and emergency departments. Level of consciousness, measured by a modified Glasgow coma scale, showed no significant change after a single 1 g dose of intravenous pyridoxine when compared to controls given saline. The mean fall in blood alcohol concentration after one hour was 33 mg dl-1 (7.2 mmol l-1) in both groups suggesting that pyridoxine has no antidotal action and no short term effect on the rate of metabolism of ethanol.

  6. Evaluation of medicinal plants and colloidal silver efficiency against Vibrio parahaemolyticus infection in Litopenaeus vannamei cultured at low salinity. (United States)

    Morales-Covarrubias, María Soledad; García-Aguilar, Noemí; Bolan-Mejía, María Del; Puello-Cruz, Ana Carmela


    In shrimp aquaculture, reduction in the use of synthetic antibiotics is a priority due to the high incidence of resistant bacteria (Vibrio) in the white shrimp Litopenaeus vannamei. An increasing number of studies show bactericidal activity of natural treatments in aquaculture. The effectiveness of neem (Azadirachta indica) and oregano (Lippia berlandieri) aqueous extracts and colloidal silver against V. parahaemolyticus were evaluated in low salinity shrimp culture. Results show that aqueous extracts of oregano and neem each present a minimum inhibitory concentration (MIC) of 62.50 mg ml-1 and inhibitory halos of 12.0 to 19.0 mm. Colloidal silver gave a MIC of 2 mg ml-1, and the inhibitory halos were found to be between 11.8 and 18.8 mm, depending on treatment concentrations. An in vivo challenge test was conducted on white shrimp postlarvae cultured at low salinity (5 practical salinity units, PSU), and a significant increase (p colloidal silver 90%), when compared to the control (0%) in the challenge test. However, no significant differences were observed between treatments, suggesting that they all act as alternative bactericidal source agents against V. parahaemolyticus infections for L. vannamei postlarvae when cultured at 5 PSU.

  7. Salinity tolerance of Picochlorum atomus and the use of salinity for contamination control by the freshwater cyanobacterium Pseudanabaena limnetica.

    Directory of Open Access Journals (Sweden)

    Nicolas von Alvensleben

    Full Text Available Microalgae are ideal candidates for waste-gas and -water remediation. However, salinity often varies between different sites. A cosmopolitan microalga with large salinity tolerance and consistent biochemical profiles would be ideal for standardised cultivation across various remediation sites. The aims of this study were to determine the effects of salinity on Picochlorum atomus growth, biomass productivity, nutrient uptake and biochemical profiles. To determine if target end-products could be manipulated, the effects of 4-day nutrient limitation were also determined. Culture salinity had no effect on growth, biomass productivity, phosphate, nitrate and total nitrogen uptake at 2, 8, 18, 28 and 36 ppt. 11 ppt, however, initiated a significantly higher total nitrogen uptake. While salinity had only minor effects on biochemical composition, nutrient depletion was a major driver for changes in biomass quality, leading to significant increases in total lipid, fatty acid and carbohydrate quantities. Fatty acid composition was also significantly affected by nutrient depletion, with an increased proportion of saturated and mono-unsaturated fatty acids. Having established that P. atomus is a euryhaline microalga, the effects of culture salinity on the development of the freshwater cyanobacterial contaminant Pseudanabaena limnetica were determined. Salinity at 28 and 36 ppt significantly inhibited establishment of P. limnetica in P. atomus cultures. In conclusion, P. atomus can be deployed for bioremediation at sites with highly variable salinities without effects on end-product potential. Nutrient status critically affected biochemical profiles--an important consideration for end-product development by microalgal industries. 28 and 36 ppt slow the establishment of the freshwater cyanobacterium P. limnetica, allowing for harvest of low contaminant containing biomass.

  8. Acute hemorrhagic edema of infancy-a rare entity

    Directory of Open Access Journals (Sweden)

    Saurabh R Jindal


    Full Text Available A patient presenting with fever and purpura often presents a diagnostic challenge for the dermatologist. Acute hemorrhagic edema of infancy (AHEI is a rare acute cutaneous leukocytoclastic vasculitic syndrome of infants leading to this presentation. We present an 18-month-old girl with AHEI who presented with fever, edema, and purpuric lesions involving the face, ears and extremities with uneventful complete recovery.

  9. Statin Pretreatment in Experimental Acute Pancreatitis

    Directory of Open Access Journals (Sweden)

    José Luiz Jesus de Almeida


    Full Text Available Context Some authors have found beneficial effect of statins in certain inflammatory conditions, but the effect of statins on acute pancreatitis is not yet defined. Objective The aim of this study was to evaluate the effect of simvastatin on an experimental model of mild and severe acute pancreatitis. Animals One hundred and one Wistar rats with cerulein or taurocholate-induced acute pancreatitis were used in this study. Design The rats were divided into two groups: Group I (n=51 received two previously i.p. injections (18±2 and 3±1 hours of simvastatin (200 μg/kg and Group II (n=50 received two previously i.p. injections of saline. Both groups were subdivided into two subgroups: mild pancreatitis (cerulein-induced; IA, n=10; IIA, n=10 and severe pancreatitis (taurocholateinduced; IB, n=41; IIB, n=40. Main outcome measures The parameters evaluated were: pancreatic vascular permeability, tissue water content, histologic lesion, amylase serum levels in rats with mild pancreatitis (subgroups A; mortality rate, serum levels of IL-6, IL-10, amylase, pulmonary myeloperoxidase activity and ascitic levels of TNF-alpha in rats with severe pancreatitis (subgroups B. Results Serum levels of IL-10 were significantly lower in the simvastatin-treated group as well as the myeloperoxidase activity. There was no significant difference in any of other studied parameters. Conclusion Simvastatin appears to reduce inflammatory cytokines and pulmonary neutrophilic activation in the severe acute pancreatitis model, but there is no significant effect on survival curve, in spite of a clear trend towards a better survival in the simvastatin group.

  10. Infant acute myocarditis mimicking acute myocardial infarction (United States)

    Tilouche, Samia; Masmoudi, Tasnim; Sahnoun, Maha; Chkirbène, Youssef; Mestiri, Sarra; Boughamoura, Lamia; Ben Dhiab, Mohamed; Souguir, Mohamed Kamel


    Myocarditis is an inflammatory disease of the myocardium with heterogeneous clinical manifestations and progression. In clinical practice, although there are many methods of diagnosis of acute myocarditis, the diagnosis remains an embarrassing dilemma for clinicians. The authors report the case of 9-month-old infant who was brought to the Pediatric Emergency Department with sudden onset dyspnea. Examination disclosed heart failure and resuscitation was undertaken. The electrocardiogram showed an ST segment elevation in the anterolateral leads with a mirror image. Cardiac enzyme tests revealed a significant elevation of troponin and creatine phosphokinase levels. A diagnosis of acute myocardial infarction was made, and heparin therapy was prescribed. The infant died on the third day after admission with cardiogenic shock. The autopsy showed dilatation of the ventricles and massive edema of the lungs. Histological examinations of myocardium samples revealed the presence of a marked lymphocytic infiltrate dissociating myocardiocytes. Death was attributed to acute myocarditis. The authors call attention to the difficulties of differential diagnosis between acute myocarditis and acute myocardial infarction especially in children, and to the important therapeutic implications of a correct diagnosis. PMID:28210569

  11. A porcine model of acute, haematogenous, localized osteomyelitis due to Staphylococcus aureus

    DEFF Research Database (Denmark)

    Johansen, Louise Kruse; Frees, Dorte; Aalbæk, Bent;


    A porcine model of acute, haematogenous, localized osteomyelitis was established. Serial dilutions of Staphylococcus aureus [5–50–500–5000–50 000 CFU/kg body weight (BW) suspended in saline or saline alone] were inoculated into the right brachial artery of pigs (BW 15 kg) separated into six groups...... of two animals. During the infection, blood was collected for cultivation, and after the animals were killed from day 5 to 15, they were necropsied and tissues were sampled for histopathology. Animals receiving =500 CFU/kg BW were free of lesions. Pigs inoculated with 5000 and 50 000 CFU/kg BW only...

  12. Nanosilica and Polyacrylate/Nanosilica: A Comparative Study of Acute Toxicity


    Ying-Mei Niu; Xiao-Li Zhu; Bing Chang; Zhao-Hui Tong; Wen Cao; Pei-Huan Qiao; Lin-Yuan Zhang; Jing Zhao; Yu-Guo Song


    We compared the acute toxicity of nanosilica and polyacrylate/nanosilica instillation in Wistar rats (n = 60). Exposure to nanosilica and polyacrylate/nanosilica showed a 30% mortality rate. When compared with saline-treated rats, animals in both exposure groups exhibited a significant reduction of PO2 (P < 0.05) at both 24 and 72 hr. after exposure. Both exposure groups exhibited a significant reduction of neutrophils in arterial blood compared to saline controls (P < 0.05) 24 hr. after expo...

  13. Infusion of hypertonic saline before elective hysterectomy: effects on cytokines and stress hormones

    DEFF Research Database (Denmark)

    Kolsen-Petersen, J A; Bendtzen, K; Tonnesen, E


    Infusion of hypertonic saline provides early haemodynamic benefits and may affect the immune system. It is unknown if infusion of hypertonic saline affects plasma cytokines and stress hormones after surgery.......Infusion of hypertonic saline provides early haemodynamic benefits and may affect the immune system. It is unknown if infusion of hypertonic saline affects plasma cytokines and stress hormones after surgery....

  14. Shallow rainwater lenses in deltaic areas with saline seepage

    Directory of Open Access Journals (Sweden)

    P. G. B. de Louw


    Full Text Available In deltaic areas with saline seepage, freshwater availability is often limited to shallow rainwater lenses lying on top of saline groundwater. Here we describe the characteristics and spatial variability of such lenses in areas with saline seepage and the mechanisms that control their occurrence and size. Our findings are based on different types of field measurements and detailed numerical groundwater models applied in the south-western delta of the Netherlands. By combining the applied techniques we could extrapolate measurements at point scale (groundwater sampling, temperature and electrical soil conductivity (TEC-probe measurements, electrical cone penetration tests (ECPT to field scale (continuous vertical electrical soundings (CVES, electromagnetic survey with EM31, and even to regional scale using helicopter-borne electromagnetic measurements (HEM. The measurements show a gradual mixing zone between infiltrating fresh rainwater and upward flowing saline groundwater. The mixing zone is best characterized by the depth of the centre of the mixing zone Dmix, where the salinity is half that of seepage water, and the bottom of the mixing zone Bmix, with a salinity equal to that of the seepage water (Cl-conc. 10 to 16 g l−1. Dmix is found at very shallow depth in the confining top layer, on average at 1.7 m below ground level (b.g.l., while Bmix lies about 2.5 m b.g.l. The model results show that the constantly alternating upward and downward flow at low velocities in the confining layer is the main mechanism of mixing between rainwater and saline seepage and determines the position and extent of the mixing zone (Dmix and Bmix. Recharge, seepage flux, and drainage depth are the controlling factors.


    Directory of Open Access Journals (Sweden)

    F Kusmiyati


    Full Text Available Peralihan fungsi lahan pertanian menjadi wilayah pemukimam dan industri menyebabkan semakinberkurangnya lahan pertanian.Hal tersebut menyebabkan pengembangan pertanian perlu diarahkan padalahan-lahan marginal seperti tanah salin.Tanah salin adalah tanah yang mengandung garam terlarut netraldalam jumlah tertentu yang berpengaruh buruk terhadap pertumbuhan dan produksi tanaman.Penelitian yangdilaksanakan bertujuan mengkaji pengaruh perbaikan tanah salin secara kimia dan biologi terhadap karakterfisiologis Calopogonium mucunoides. Rancangan yang digunakan adalah rancangan acak lengkap dengan 3ulangan. Perbaikan tanah salin dilakukan melalui penambahan gipsum (P1, pupuk kandang (P2, abu sekampadi (P3, tanaman halofita (P4, gipsum dan pupuk kandang (P5, gipsum dan abu sekam padi (P6, gipsumdantanamanhalofita (P7, pupuk kandang dan abu sekam padi (P8, pupuk kandang dan tanaman halofita(P9, abusekam padi dan tanaman halofita (P10 dan tanpa penambahan sebagai kontrol (P0. Parameter yangdiamati adalah kandungan klorofil a, kandungan klorofil b, kandungan total klorofil, aktivitas nitrat reduktase,luas daun dan laju fotosintesis.Data yang diperoleh dianalisis dengan sidik ragam dan uji lanjut dengan ujiwilayah ganda Duncan. Hasil penelitian menunjukkan kandungan klorofil a, klorofil b, total klorofil, aktivitasnitrat reduktase dan laju fotosintesis calopo berbeda nyata (P<0,05 lebih tinggi pada perlakuan perbaikantanah salin dibandingkan kontrol. Kandungan klorofil a, klorofil b dan total klorofil calopo pada perlakuankombinasi pupuk kandang dan abu sekam padi serta kombinasi gipsum dan pupuk kandang berbeda nyata(P<0,05 lebih tinggi dibandingkan perlakuan lainnya. Aktivitas nitrat reduktase dan laju fotosintesis calopopada perlakuan kombinasi pupuk kandang dan abu sekam padi serta perlakuan pupuk kandang berbeda nyata(P<0,05 lebih tinggi daripada perlakuan lainnya. Simpulan adalah perbaikan tanah salin dengan penambahankombinasi pupuk kandang dan abu

  16. Hydrologic factors controlling groundwater salinity in northwestern coastal zone, Egypt

    Indian Academy of Sciences (India)

    Nahla A Morad; M H Masoud; S M Abdel Moghith


    The aim of this article is to assess the main factors influencing salinity of groundwater in the coastal area between El Dabaa and Sidi Barani, Egypt. The types and ages of the main aquifers in this area are the fractured limestone of Middle Miocene, the calcareous sandstone of Pliocene and the Oolitic Limestone of Pleistocene age. The aquifers in the area are recharged by seasonal rainfall of the order of 150 mm/year. The relationship of groundwater salinity against the absolute water level, the well drilling depth, and the ability of aquifer to recharge has been discussed in the present work. The ability of aquifer to locally recharge by direct rainfall is a measure of the vertical permeability due to lithological and structural factors that control groundwater salinity in the investigated aquifers. On the other hand, the fracturing system as well as the attitude of the surface water divide has a prime role in changing both the mode of occurrence and the salinity of groundwater in the area. Directly to the west of Matrouh, where the coastal plain is the narrowest, and east of Barrani, where the coastal plain is the widest, are good examples of this concept, where the water salinity attains its maximum and minimum limits respectively. Accordingly, well drilling in the Miocene aquifer, in the area between El Negila and Barrani to get groundwater of salinities less than 5000 mg/l is recommended in this area, at flow rate less than 10m3/hr/well. In other words, one can expect that the brackish water is probably found where the surface water divide is far from the shore line, where the Wadi fill deposits dominate (Quaternary aquifer), acting as a possible water salinity by direct rainfall and runoff.

  17. Seed priming to alleviate salinity stress in germinating seeds. (United States)

    Ibrahim, Ehab A


    Salinity is one of the major abiotic stresses that affect crop production in arid and semiarid areas. Seed germination and seedling growth are the stages most sensitive to salinity. Salt stress causes adverse physiological and biochemical changes in germinating seeds. It can affect the seed germination and stand establishment through osmotic stress, ion-specific effects and oxidative stress. The salinity delays or prevents the seed germination through various factors, such as a reduction in water availability, changes in the mobilization of stored reserves and affecting the structural organization of proteins. Various techniques can improve emergence and stand establishment under salt conditions. One of the most frequently utilized is seed priming. The process of seed priming involves prior exposure to an abiotic stress, making a seed more resistant to future exposure. Seed priming stimulates the pre-germination metabolic processes and makes the seed ready for radicle protrusion. It increases the antioxidant system activity and the repair of membranes. These changes promote seed vigor during germination and emergence under salinity stress. The aim of this paper is to review the recent literature on the response of plants to seed priming under salinity stress. The mechanism of the effect of salinity on seed germination is discussed and the seed priming process is summarized. Physiological, biochemical and molecular changes induced by priming that lead to seed enhancement are covered. Plants' responses to some priming agents under salinity stress are reported based on the best available data. For a great number of crops, little information exists and further research is needed.

  18. Assessment of Satellite Images for Soil Salinity Studies

    Directory of Open Access Journals (Sweden)

    S.H. Sanaeinejad


    Full Text Available Soil salinity is one of the main environmental problems affecting extensive area in the world. There are some problems with traditional data collection methods for soil studies. Using the new methods and techniques such as remote sensing could overcome most of these problems. However using these data in areas with uncommon usages needed some researches to find the best calibration between the data and real situations in soil. This research was carried out using Landsat satellite images in Neyshabour area, North East of Iran. In order to prepare suitable learning samples for the image processing in this study, 300 locations were randomly selected in the area, among which 273 locations were finally selected as suitable surface soil samples. All samples were moved to laboratory and their electrical conductivity was measured. Six reflective bands of ETM+ satellite images taken from the study area in 2002 were used for the image processing analysis. Classification of different soil salinities was carried out using common algorithms of image classification based on the best composition bands and using statistical methods between soil salinity variables and digital numbers of the images to represent a suitable method. the research results showed that the reflective bands 7, 3, 4 and 1 are the best band composition for preparing the color composite images and for the classification of the salinity in this area. The highest coefficient of determination was R2=0.311 and R2=0.44 for saline and non-saline soil respectively using band 2 and 3 of the images at 5% significant level. Based on the results, it can be concluded that the potential of ETM+ images for delineation and identification of different soil salinity are limited.

  19. Wind forcing of salinity anomalies in the Denmark Strait overflow

    Directory of Open Access Journals (Sweden)

    S. Hall


    Full Text Available The overflow of dense water from the Nordic Seas to the North Atlantic through Denmark Strait is an important part of the global thermohaline circulation. The salinity of the overflow plume has been measured by an array of current meters across the continental slope off the coast of Angmagssalik, southeast Greenland since September 1998. During 2004 the salinity of the overflow plume changed dramatically, with the entire width of the array (70 km freshening between January 2004 and July 2004, with a significant negative salinity anomaly of about 0.06 in May. The event in May represents a fresh anomaly of over 3 standard deviations from the mean since recording began in 1998. We show that the OCCAM 1/12° Ocean General Circulation Model not only reproduces the 2004 freshening event (r=0.96, p<0.01, but also correlates well with salinity observations over a previous 6 year period (r=0.54, p<0.01. Consequently the physical processes causing the 2004 anomaly and prior variability in salinity are investigated using the model output. Our results reject the hypotheses that the anomaly is caused by processes occurring between the overflow sill and the moorings, or by an increase in upstream net freshwater input. Instead, we show that the 2004 salinity anomaly is caused by an increase in volume flux of low salinity water, with a potential density greater than 27.60 kg m−3, flowing towards the Denmark Strait sill in the East Greenland Current. This is caused by an increase of southward wind stress upstream of the sill at around 75° N 20° W four and a half months earlier, and an associated spin-up of the Greenland Sea Gyre.

  20. Proteomics, metabolomics, and ionomics perspectives of salinity tolerance in halophytes. (United States)

    Kumari, Asha; Das, Paromita; Parida, Asish Kumar; Agarwal, Pradeep K


    Halophytes are plants which naturally survive in saline environment. They account for ∼1% of the total flora of the world. They include both dicots and monocots and are distributed mainly in arid, semi-arid inlands and saline wet lands along the tropical and sub-tropical coasts. Salinity tolerance in halophytes depends on a set of ecological and physiological characteristics that allow them to grow and flourish in high saline conditions. The ability of halophytes to tolerate high salt is determined by the effective coordination between various physiological processes, metabolic pathways and protein or gene networks responsible for delivering salinity tolerance. The salinity responsive proteins belong to diverse functional classes such as photosynthesis, redox homeostasis; stress/defense, carbohydrate and energy metabolism, protein metabolism, signal transduction and membrane transport. The important metabolites which are involved in salt tolerance of halophytes are proline and proline analog (4-hydroxy-N-methyl proline), glycine betaine, pinitol, myo-inositol, mannitol, sorbitol, O-methylmucoinositol, and polyamines. In halophytes, the synthesis of specific proteins and osmotically active metabolites control ion and water flux and support scavenging of oxygen radicals under salt stress condition. The present review summarizes the salt tolerance mechanisms of halophytes by elucidating the recent studies that have focused on proteomic, metabolomic, and ionomic aspects of various halophytes in response to salinity. By integrating the information from halophytes and its comparison with glycophytes could give an overview of salt tolerance mechanisms in halophytes, thus laying down the pavement for development of salt tolerant crop plants through genetic modification and effective breeding strategies.

  1. Proteomics, metabolomics and ionomics perspectives of salinity tolerance in halophytes

    Directory of Open Access Journals (Sweden)



    Full Text Available Halophytes are plants which naturally survive in saline environment. They account for approximately 1% of the total flora of the world. They include both dicots and monocots and are distributed mainly in arid, semi-arid inlands and saline wet lands along the tropical and sub-tropical coasts. Salinity tolerance in halophytes depends on a set of ecological and physiological characteristics that allow them to grow and flourish in high saline conditions. The ability of halophytes to tolerate high salt is determined by the effective coordination between various physiological processes, metabolic pathways and protein or gene networks responsible for delivering salinity tolerance. The salinity responsive proteins belong to diverse functional classes such as photosynthesis, redox homeostasis, stress/defence, carbohydrate and energy metabolism, protein metabolism, signal transduction and membrane transport. The important metabolites which are involved in salt tolerance of halophytes are proline and proline analogue (4-hydroxy-N-methyl proline, glycine betaine, pinitol, myo-inositol, mannitol, sorbitol, O-methylmucoinositol and polyamines. In halophytes, the synthesis of specific proteins and osmotically active metabolites control ion and water flux and support scavenging of oxygen radicals under salt stress condition. The present review summarizes the salt tolerance mechanisms of halophytes by elucidating the recent studies that have focused on proteomic, metabolomic and ionomic aspects of various halophytes in response to salinity. By integrating the information from halophytes and its comparison with glycophytes could give an overview of salt tolerance mechanisms in halophytes, thus laying down the pavement for development of salt tolerant crop plants through genetic modification and effective breeding strategies.

  2. Acute peritonitis as the first presentation of valvular cardiomyopathy.

    LENUS (Irish Health Repository)

    Higgins, Nikki


    Valvular cardiomyopathy can present a diagnostic challenge in the absence of overt cardiac symptoms. This report describes the case of a 46-year-old woman who presented with acute peritonitis associated with vomiting and abdominal distension. Subsequent abdominal computed tomography and ultrasound revealed bibasal pleural effusions, ascites, and normal ovaries. An echocardiogram revealed that all cardiac chambers were dilated with a global decrease in contractility and severe mitral, tricuspid, and aortic regurgitation. A diagnosis of cardiomyopathy with acute heart failure, secondary to valvular heart disease, was secured. Acute peritonitis as the presenting feature of valvular cardiomyopathy is a rare clinical entity.


    NARCIS (Netherlands)



    Both acute and long-term effects of haloperidol and clozapine on Fos-like immunoreactive nuclei in several rat forebrain areas were quantified. Rats were treated with saline (1 ml/, control), haloperidol (1 mg/ and clozapine (20 mg/ i.p. for 21 days. Two hours before perfusion fi

  4. Predicting species’ tolerance to salinity and alkalinity using distribution data and geochemical modelling: a case study using Australian grasses (United States)

    Saslis-Lagoudakis, C. Haris; Hua, Xia; Bui, Elisabeth; Moray, Camile; Bromham, Lindell


    Background and Aims Salt tolerance has evolved many times independently in different plant groups. One possible explanation for this pattern is that it builds upon a general suite of stress-tolerance traits. If this is the case, then we might expect a correlation between salt tolerance and other tolerances to different environmental stresses. This association has been hypothesized for salt and alkalinity tolerance. However, a major limitation in investigating large-scale patterns of these tolerances is that lists of known tolerant species are incomplete. This study explores whether species’ salt and alkalinity tolerance can be predicted using geochemical modelling for Australian grasses. The correlation between taxa found in conditions of high predicted salinity and alkalinity is then assessed. Methods Extensive occurrence data for Australian grasses is used together with geochemical modelling to predict values of pH and electrical conductivity to which species are exposed in their natural distributions. Using parametric and phylogeny-corrected tests, the geochemical predictions are evaluated using a list of known halophytes as a control, and it is determined whether taxa that occur in conditions of high predicted salinity are also found in conditions of high predicted alkalinity. Key Results It is shown that genera containing known halophytes have higher predicted salinity conditions than those not containing known halophytes. Additionally, taxa occurring in high predicted salinity tend to also occur in high predicted alkalinity. Conclusions Geochemical modelling using species’ occurrence data is a potentially useful approach to predict species’ relative natural tolerance to challenging environmental conditions. The findings also demonstrate a correlation between salinity tolerance and alkalinity tolerance. Further investigations can consider the phylogenetic distribution of specific traits involved in these ecophysiological strategies, ideally by

  5. 78 FR 49296 - Centennial Challenges 2014 Sample Return Robot Challenge (United States)


    ... SPACE ADMINISTRATION Centennial Challenges 2014 Sample Return Robot Challenge AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of Centennial Challenges 2014 Sample Return Robot... Robot Challenge is scheduled and teams that wish to compete may register. Centennial Challenges is...

  6. Comparison of normal saline, hypertonic saline albumin and terlipressin plus hypertonic saline albumin in an infant animal model of hypovolemic shock.

    Directory of Open Access Journals (Sweden)

    Javier Urbano

    Full Text Available In series of cases and animal models suffering hemorrhagic shock, the use of vasopressors has shown potential benefits regarding hemodynamics and tissue perfusion. Terlipressin is an analogue of vasopressin with a longer half-life that can be administered by bolus injection. We have previously observed that hypertonic albumin improves resuscitation following controlled hemorrhage in piglets. The aim of the present study was to analyze whether the treatment with the combination of terlipressin and hypertonic albumin can produce better hemodynamic and tissular perfusion parameters than normal saline or hypertonic albumin alone at early stages of hemorrhagic shock in an infant animal model.Experimental, randomized animal study including 39 2-to-3-month-old piglets. Thirty minutes after controlled 30 ml/kg bleed, pigs were randomized to receive either normal saline (NS 30 ml/kg (n = 13, 5% albumin plus 3% hypertonic saline (AHS 15 ml/kg (n = 13 or single bolus of terlipressin 15 μg/kg i.v. plus 5% albumin plus 3% hypertonic saline 15 ml/kg (TAHS (n = 13 over 30 minutes. Global hemodynamic and tissular perfusion parameters were compared.After controlled bleed a significant decrease of blood pressure, cardiac index, central venous saturation, carotid and peripheral blood flow, brain saturation and an increase of heart rate, gastric PCO2 and lactate was observed. After treatment no significant differences in most hemodynamic (cardiac index, mean arterial pressure and perfusion parameters (lactate, gastric PCO2, brain saturation, cutaneous blood flow were observed between the three therapeutic groups. AHS and TAHS produced higher increase in stroke volume index and carotid blood flow than NS.In this pediatric animal model of hypovolemic shock, albumin plus hypertonic saline with or without terlipressin achieved similar hemodynamics and perfusion parameters than twice the volume of NS. Addition of terlipressin did not produce better results than AHS.

  7. Acute myopericarditis masquerading as acute myocardial infarction

    Institute of Scientific and Technical Information of China (English)

    Wen Tian; Zixin Zhang; Xiaojuan Bai; Dingyin Zeng; Guoxian Qi


    Patients with abrupt onset of chest pain, ischemic ECG abnormalities and elevated levels of cardiac markers could be given a diagnosis of acute myocardial infarction. However, some other diseases should be taken into consideration in this clinical setting when coronary arteries are proven to be normal. Here we report a case of acute myopericarditis with clinical presentation of myocardial infarction and normal coronary anatomy. The Herpes Simplex Virus Ⅱ was considered as the organism causing myopericarditis and the patient was recovered by the treatment with valacicloavir. A precise diagnosis is a prerequisite of successful treatment and favorable prognosis.

  8. National Drug IQ Challenge (United States)

    ... Reto nacional del coeficiente intelectual (CI) sobre las drogas y el alcohol 2016 National Drug IQ Challenge ... Reto nacional del coeficiente intelectual (CI) sobre las drogas y el alcohol 2015 National Drug IQ Challenge ...

  9. [Acute kidney injury

    NARCIS (Netherlands)

    Hageman, D.; Kooman, J.P.; Lance, M.D.; Heurn, L.W. van; Snoeijs, M.G.


    - 'Acute kidney injury' is modern terminology for a sudden decline in kidney function, and is defined by the RIFLE classification (RIFLE is an acronym for Risk, Injury, Failure, Loss and End-stage kidney disease).- Acute kidney injury occurs as a result of the combination of reduced perfusion in the

  10. Corticosteroids for acute rhinosinusitis

    NARCIS (Netherlands)

    Venekamp, R.P.


    Acute rhinosinusitis is a common reason for consultations in general practice, with typically 50 cases seen by a general practitioner annually. Traditionally, acute rhinosinusitis has been regarded as a bacterial infection of the paranasal sinuses. Therefore, numerous randomised controlled trials ha

  11. Leukocytosis in acute stroke

    DEFF Research Database (Denmark)

    Kammersgaard, L P; Jørgensen, H S; Nakayama, H


    Leukocytosis is a common finding in the acute phase of stroke. A detrimental effect of leukocytosis on stroke outcome has been suggested, and trials aiming at reducing the leukocyte response in acute stroke are currently being conducted. However, the influence of leukocytosis on stroke outcome has...

  12. Acute recurrent polyhydramnios

    DEFF Research Database (Denmark)

    Rode, Line; Bundgaard, Anne; Skibsted, Lillian


    Acute recurrent polyhydramnios is a rare occurrence characterized by a poor fetal outcome. This is a case report describing a 34-year-old woman presenting with acute recurrent polyhydramnios. Treatment with non-steroidal anti-inflammatory drugs (NSAID) and therapeutic amniocenteses was initiated ...

  13. Chemical Composition, in vitro Digestibility and Fermentative Gas Production of Kochia scoparia Irrigated by Water Containing Different Level of Salinity

    Directory of Open Access Journals (Sweden)

    reza valizadeh


    Full Text Available Introduction Shortage of feedstuff is one of the important problems of animal nutrition in Iran. Salinity is a global problem worldwide in particular in arid and semi-arid zones such as Iran. Salinity is an important factor in the growth of plants. Its initial effect to plants is through its effect in the availability of water to plants. Halophytes have good ability to draw water from soils of low water potential due to their ability to maintain a salt balance comparable to the salt in the soil they are growing. Lands in high irrigation districts are susceptible to soil salinization. Soil salinization is the primary cause of productivity decline in highly developed and irrigated land schemes While the increase in soil and water salinity in many agricultural areas of the world has created major challenges in the production of food crops, it has also presented some new prospects for livestock agriculture. There are plants that grow under saline conditions, and historically, they have been opportunistically used as fodder for grazing livestock or as components of mixed rations to replace roughage. Using of seawater for irrigation of this plant because of shortage of sweet water and for higher production of these plants was necessary for feedstuff. The aim of this study was evaluation of Chemical composition, In vitro digestibility and gas production of Kochia scoparia under six level of salinity including 10, 20, 30, 40, 50, 60 ds/m. Materials and Methods The Kochia scoparia was irrigated by normal tap water (the control and water containing 6 levels of salinity including 10, 20, 30, 40, 50, 60 deci Siemens per meter (ds/m. The salinity was applied gradually in accordance with the plant growth advancement (2 ds/m increment per each irrigation period. Oven dried (65◦C for 48 h chopped samples were ground to pass through a 1-mm screen. The samples were analyzed according to the standard procedures for chemical composition (AOAC 2000, Van-Soest et

  14. Overview on calibration and validation activities for ESA's Soil Moisture and Ocean Salinity Mission (United States)

    Mecklenburg, Susanne; Bouzinac, Catherine; Delwart, Steven


    exercise to verify that the methodology proposed actually meets the foreseen performances. Other activities include the deployment of the ground-based ESA funded ELBARA radiometers. Also, in collaboration with the Technical University Vienna, ESA funds the establishment of a soil moisture network data hosting facility in support to the SMOS calibration and validation activities. The validation of sea surface salinity data products will be a challenging task requiring a highly accurate and stable instrument calibration. At local scales, the foreseen validation activities are focused on a better understanding of the emission of L-band radiation from the sea surface through dedicated airborne campaigns, whereas validation at global scales will rely on buoy networks and basin scale ocean models. Close collaboration with the NASA Aquarius Team will further contribute to the validation of sea surface salinity data products. A variety of campaigns, such as DOMEX, CoSMOS, WISE, LOSAC, EUROSTARRS, FROG, SMOSREX have been (and will be) performed to investigate uncertainties in the soil moisture and ocean salinity retrieval. The major aspects to investigate with regard to soil moisture are the influence of the various types of vegetation and their seasonal variability, as well as the influence of surface roughness. Over oceans, the impact of sea-surface state on the polarimetric radiometric signal is the main issue. The DOMEX campaigns will provide information for vicarious calibration over Antarctica. The presentation will provide an overview on the calibration and validation activities carried out in the SMOS commissioning phase.

  15. Synoptic monthly gridded Global Temperature and Salinity Profile Programme (GTSPP) water temperature and salinity from January 1990 to December 2009 (NCEI Accession 0138647) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The synoptic gridded Global Temperature and Salinity Profile Programme (SG-GTSPP) provides world ocean 3D gridded temperature and salinity data in monthly increment...

  16. Acute kidney injury during pregnancy. (United States)

    Van Hook, James W


    Acute kidney injury complicates the care of a relatively small number of pregnant and postpartum women. Several pregnancy-related disorders such as preeclampsia and thrombotic microangiopathies may produce acute kidney injury. Prerenal azotemia is another common cause of acute kidney injury in pregnancy. This manuscript will review pregnancy-associated acute kidney injury from a renal functional perspective. Pathophysiology of acute kidney injury will be reviewed. Specific conditions causing acute kidney injury and treatments will be compared.

  17. Pharm GKB: Leukemia, Monocytic, Acute [PharmGKB

    Lifescience Database Archive (English)

    Full Text Available Overview Alternate Names: Synonym Acute Monoblastic Leukemia; Acute Monoblastic Leukemias; Acute... Monocytic Leukemia; Acute Monocytic Leukemias; Acute monoblastic leukaemia; Acute monoblastic leukemia; Acute... monocytic leukaemia; Acute monocytic leukemia, morphology; Acute monocytoid leukemia; Leukemia, Acute... Monoblastic; Leukemia, Acute Monocytic; Leukemia, Monoblastic, Acute; Leukemia, Myeloid, Acute... Schilling-Type Myeloid; Leukemias, Acute Monoblastic; Leukemias, Acute Monocytic; M5a - Acute monoblastic leukaemia; M5a - Acute

  18. [Chronic pancreatitis, acute pancreatitis]. (United States)

    Mabuchi, T; Katada, N; Nishimura, D; Hoshino, H; Shimizu, F; Suzuki, R; Sano, H; Kato, K


    MRCP has been recognized as a safe and noninvasive diagnostic method. In the present study we evaluated the usefulness of MRCP in diagnosis of chronic and acute pancreatitis. Two-dimensional fast asymmetric spin-echo (FASE) MRCP was performed in 40 patients with chronic pancreatitis and 13 with acute pancreatitis. In 29 patients (72.5%) with chronic pancreatitis and 9 (66.7%) with acute pancreatitis, main pancreatic duct (MPD) was visualized entirely. MRCP could demonstrate the characteristic findings of chronic pancreatitis such as dilatation and irregularity of MPD in most cases. In acute pancreatitis, MRCP indicated that MPD was normal in diameter, but irregular in configuration compared with that of the control group. MRCP may facilitate the diagnosis of chronic and acute pancreatitis.

  19. Drivers of long-term ocean salinity changes (United States)

    Durack, Paul


    Previous work has highlighted near-surface salinity pattern amplification (PA) and depth-integrated halosteric (salinity-driven) sea-level changes in long-term change estimates from observations and climate model simulations. These suggest that fresh ocean regions are becoming fresher, and salty regions saltier in part to a response to evaporation minus precipitation (E-P; water cycle) changes driven by a warming Earth. While near-surface salinity changes relate to the climatological mean (fresh becoming fresher, salty becoming saltier), subsurface salinity changes have also been recorded. Similar to the near-surface, these changes represent a complex three-dimensional structure that is different in each ocean basin. Like near-surface changes, subsurface salinity changes also share a strong correspondence with the subsurface climatological mean. When integrated through the depth of observed data coverage (0-2000 m), these show a clear basin halosteric contrast - a freshening Pacific and an enhancing Atlantic salinity a fingerprint of change that has been successfully attributed to anthropogenic climate change in previous studies. As long-term observational insights are limited, model simulations provide a novel method to assess and validate observed change estimates, and attribute the drivers of long-term change. Using the CMIP (Coupled Model Intercomparison Project phase 3 & 5) 20C3M/historical (20th century), SRES/RCP (future 21st century) and pre-industrial (piControl; unforced) simulations, these basin salinity change contrasts are investigated and their relationship to simulated E-P (water cycle) changes is diagnosed. The intrinsic variability of both modelled salinity and E-P change fields is investigated to ascertain an envelope of unforced (piControl) climate variability, an estimate currently unavailable for long-term observational estimates due to poor measurement coverage. These unforced distributions are compared to those of weakly- (20C3M

  20. Passive Microwave Measurements of Salinity: The Gulf Stream Experiment (United States)

    LeVine, D. M.; Koblinsky, C.; Haken, M.; Howden, S.; Bingham, F.; Hildebrand, Peter H. (Technical Monitor)


    Passive microwave sensors at L-band (1.4 GHz) operating from aircraft have demonstrated that salinity can be measured with sufficient accuracy (I psu) to be scientifically meaningful in coastal waters. However, measuring salinity in the open ocean presents unresolved issues largely because of the much greater accuracy (approximately 0.2 psu) required of global maps to be scientifically viable. The development of a satellite microwave instrument to make global measurements of SSS (Sea Surface Salinity) is the focus of a joint JPL/GSFC/NASA ocean research program called Aquarius. In the summer of 1999 a series of measurements called, The Gulf Stream Experiment, were conducted as part of research at the Goddard Space Flight Center to test the potential for passive microwave remote sensing of salinity in the open ocean. The measurements consisted of airborne microwave instruments together with ships and drifters for surface truth. The study area was a 200 km by 100 km rectangle about 250 km east of Delaware Bay between the continental shelf waters and north wall of the Gulf Stream. The primary passive instruments were the ESTAR radiometer (L-band, H-pol) and the SLFMR radiometer (L-band, V-pol). In addition, the instruments on the aircraft included a C-band radiometer (ACMR), an ocean wave scatterometer (ROWS) and an infrared radiometer (for surface temperature). These instruments were mounted on the NASA P-3 Orion aircraft. Sea surface measurements consisted of thermosalinograph data provided by the R/V Cape Henlopen and the MN Oleander, and data from salinity and temperature sensors on three surface drifters deployed from the R/V Cape Henlopen. The primary experiment period was August 26-September 2, 1999. During this period the salinity field within the study area consisted of a gradient on the order of 2-3 psu in the vicinity of the shelf break and a warm core ring with a gradient of 1-2 psu. Detailed maps were made with the airborne sensors on August 28 and 29 and

  1. Implications of salinity pollution hotspots on agricultural production (United States)

    Floerke, Martina; Fink, Julia; Malsy, Marcus; Voelker, Jeanette; Alcamo, Joseph


    Salinity pollution can have many negative impacts on water resources used for drinking, irrigation, and industrial purposes. Elevated concentrations of salinity in irrigation water can lead to decreased crop production or crop death and, thus, causing an economic problem. Overall, salinity pollution is a global problem but tends to be more severe in arid and semi-arid regions where the dilution capacity of rivers and lakes is lower and the use of irrigation higher. Particularly in these regions agricultural production is exposed to high salinity of irrigation water as insufficient water quality further reduces the available freshwater resources. According to the FAO, irrigated agriculture contributes about 40 percent of the total food production globally, and therefore, high salinity pollution poses a major concern for food production and food security. We use the WaterGAP3 modeling framework to simulate hydrological, water use, and water quality conditions on a global scale for the time period 1990 to 2010. The modeling framework is applied to simulate total dissolved solids (TDS) loadings and in-stream concentrations from different point and diffuse sources to get an insight on potential environmental impacts as well as risks to agricultural food production. The model was tested and calibrated against observed data from GEMStat and literature sources. Although global in scope, the focus of this study is on developing countries, i.e., in Africa, Asia, and Latin America, as these are most threatened by salinity pollution. Furthermore, insufficient water quality for irrigation and therefore restrictions in irrigation water use are examined, indicating limitations to crop production. Our results show that elevated salinity concentrations in surface waters mainly occur in peak irrigation regions as irrigated agriculture is not only the most relevant water use sector contributing to water abstractions, but also the dominant source of salinity pollution. Additionally

  2. Gene expression responses of threespine stickleback to salinity: implications for salt-sensitive hypertension

    Directory of Open Access Journals (Sweden)

    Gang eWang


    Full Text Available Despite some recent success with genome-wide association studies (GWAS, identifying hypertension (HTN-susceptibility loci in the general population remains difficult. Here, we present a novel strategy to address the challenge by studying salinity adaptation in the threespine stickleback, a fish species with diverse salt-handling ecotypes. We acclimated native freshwater (FW and anadromous, saltwater (SW threespine sticklebacks to fresh, brackish, and sea water for 30 days, and applied RNA sequencing to determine the gene expression in fish kidneys. We identified 1,844 salt-responsive genes that were differentially expressed between FW sticklebacks acclimated to different salinities and/or between SW and FW sticklebacks acclimated to full-strength sea water. Significant overlap between stickleback salt-responsive genes and human genes implicated in HTN was detected (P < 10-7, hypergeometric test, suggesting a striking similarity in genetic mechanisms of salt handling between threespine sticklebacks and humans. The overlapping genes included a newly discovered HTN gene—MAP3K15, whose expression in FW stickleback kidneys decreases with salinity. These also included genes located in the GWAS loci such as AGTRAP-PLOD1 and CYP1A1-ULK3, which contain multiple potentially causative genes contributing to HTN susceptibility that need to be prioritized for study. We show evidence that stickleback salt-responsive genes provide valuable information facilitating the identification of human HTN genes. We conclude that threespine sticklebacks may be used as a model, complementary to existing animal models, in human HTN research.

  3. Germination of Spores of Astrobiologically Relevant Bacillus Species in High-Salinity Environments (United States)

    Nagler, Katja; Julius, Christina; Moeller, Ralf


    In times of increasing space exploration and search for extraterrestrial life, new questions and challenges for planetary protection, aiming to avoid forward contamination of different planets or moons with terrestrial life, are emerging. Spore-forming bacteria such as Bacillus species have a high contamination potential due to their spores' extreme resistance, enabling them to withstand space conditions. Spores require liquid water for their conversion into a growing cell (i.e., spore germination and subsequent growth). If present, water on extraterrestrial planets or moons is likely to be closely associated with salts (e.g., in salty oceans or brines), thus constituting high-salinity environments. Spores of Bacillus subtilis can germinate despite very high salt concentrations, although salt stress does exert negative effects on this process. In this study, germination and metabolic reactivation ("outgrowth") of spores of five astrobiologically relevant Bacillus species (B. megaterium, B. pumilus SAFR-032, B. nealsonii, B. mojavensis, and B. vallismortis) in high salinity (≤3.6 M NaCl) were investigated. Spores of different species exhibited different germination and outgrowth capabilities in high salinity, which strongly depended on germination conditions, especially the exact composition of the medium. In this context, a new "universal" germination trigger for Bacillus spores, named KAGE (KCl, L-alanine, D-glucose, ectoine), was identified, which will be very useful for future comparative germination and outgrowth studies on different Bacillus species. Overall, this study yielded interesting new insights on salt stress effects on spore germination and points out the difficulty of predicting the potential of spores to contaminate salty environments on extraterrestrial celestial bodies.

  4. Biobehavioral Correlates of Depression in Reaction to Mental and Physical Challenge (United States)


    catecholamines in response to intense exercise will diminish ( Wilmore & Costill, 2001). Acute exercise also increases ACTH and subsequently cortisol (Deuster...cortisol attenuates after an individual becomes more fit ( Wilmore & Costill, 2001). Neurohormonal response to physical challenge in depression

  5. The Backpack Design Challenge (United States)

    Roman, Harry T.


    Something as simple as carrying books to school can be an interesting design challenge for students. It's an old problem that gets reinvented from time to time. In this article, the author discusses a backpack design challenge in which teachers work with students to design another way to carry books to school. The challenge started by trying to…

  6. Effects of Soil Salinity on Sucrose Metabolism in Cotton Leaves.

    Directory of Open Access Journals (Sweden)

    Jun Peng

    Full Text Available This study investigated sucrose metabolism of the youngest fully expanded main-stem leaf (MSL and the subtending leaf of cotton (Gossypium hirsutum L. boll (LSCB of salt-tolerant (CCRI-79 and salt-sensitive (Simian 3 cultivars and its relationship to boll weight under low, medium and high soil salinity stress in Dafeng, China, in 2013 and 2014. The results showed that with increased soil salinity, 1 both the chlorophyll content and net photosynthetic rate (Pn decreased, while the internal CO2 concentration firstly declined, and then increased in the MSL and LSCB; 2 carbohydrate contents in the MSL reduced significantly, while sucrose and starch contents in the LSCB increased, as did the activities of sucrose phosphate synthase (SPS and sucrose synthase (SuSy in both the MSL and LSCB; 3 but invertase activity in both the MSL and LSCB did not change significantly. Our study also showed that the LSCB was more sensitive to soil salinity than was the MSL. Of the measured physiological indices, higher SPS activity, mainly controlled by sps3, may contribute to adaption of the LSCB to soil salinity stress because SPS is beneficial for efficiently sucrose synthesis, reduction of cellular osmotic potential and combined actions of Pn, and sucrose transformation rate and SPS may contribute to the reduction in boll weight under soil salinity stress.

  7. Effect of salinity on zinc uptake by Brassica juncea. (United States)

    Novo, Luís A B; Covelo, Emma F; González, Luís


    Salinity is a major worldwide problem that affects agricultural soils and limits the reclamation of contaminated sites. Despite the large number of research papers published about salt tolerance in Brassica juncea L., there are very few accounts concerning the influence of salinity on the uptake of trace metals. In this study, B. juncea plants divided through soil sets comprising 0, 900 and 1800 mg Zn kg(-1), were treated with solutions containing 0, 60 and 120 mmol L(-1) of NaCl, with the purpose of observing the effect of salt on Zn uptake, and some physiological responses throughout the 90 days experiment. Increasing concentrations of NaCl and Zn produced a decline in the ecophysiological and biochemical properties of the plants, with observable synergistic effects on parameters like shoot dry weight, leaf area, or photochemical efficiency. Nevertheless, plants treated with 60 mmol L(-1) of NaCl accumulated striking harvestable amounts of Zn per plant that largely exceed those reported for Thlaspi caerulescens. It was concluded that salinity could play an important role on the uptake of Zn by B. juncea. The potential mechanisms behind these results are discussed, as well as the implications for phytoremediation of Zn on saline and non-saline soils.

  8. Assessing the impacts of salinity and nutrient stress to Ruppia ... (United States)

    Healthy seagrass beds were once found throughout the shallow areas of Narragansett Bay, R.I. but have disappeared due to infilling, pollution and disease. In Greenwich Bay, a highly developed embayment within Narragansett Bay, Ruppia maritima has colonized an area on the northern shore historically dominated by Zostera marina. Ruppia is extremely salinity tolerant, and may also be more nutrient tolerant than Zostera. To test this hypothesis 6-week microcosm experiments were conducted in the summers of 2014 and 2015. Microcosms were renewed daily to simulate tidal flushing and the water column was dosed with a 15N tracer for the first week of the experiments. In the 2014 microcosm experiment two salinity (20, 30 ppt) and four nutrient (0, 5, 10, 30 µM inorganic N) levels were used to test the species’ relative tolerance. This experiment yielded structurally significant results for Ruppia but no significant differences were detected for Zostera. In 2015 this experiment was performed for a second time with lower salinity (5, 30 ppt) and higher nutrients (0, 30, 100, 300, 1000 µM inorganic N) in order to determine Zostera’s tolerance to nutrient and salinity stress and confirm the previously observed Ruppia results. Both species had significant structural responses to the nutrient and salinity variables. Isotopic analysis run on above-ground tissue indicated that with increasing nutrient levels δ15N in the seagrass shoots increased, suggesting that nutrients

  9. Saline water pollution in groundwater: issues and its control

    Directory of Open Access Journals (Sweden)

    Setyawan Purnama


    Full Text Available Nowadays, saline water pollution has been gaining its importance as the major issue around the world, especially in the urban coastal area. Saline water pollution has major impact on human life and livelihood. It´s mainly a result from static fossil water and the dynamics of sea water intrusion.. The problem of saline water pollution caused by seawater intrusion has been increasing since the beginning of urban population. The problem of sea water intrusion in the urban coastal area must be anticipated as soon as possible especially in the urban areas developed in coastal zones,. This review article aims to; (i analyze the distribution of saline water pollution on urban coastal area in Indonesia and (ii analyze some methods in controlling saline water pollution, especially due to seawater intrusion in urban coastal area. The strength and weakness of each method have been compared, including (a applying different pumping patterns, (b artificial recharge, (c extraction barrier, (d injection barrier and (e subsurface barrier. The best method has been selected considering its possible development in coastal areas of developing countries. The review is based considering the location of Semarang coastal area, Indonesia. The results have shown that artificial recharge and extraction barrier are the most suitable methods to be applied in the area.

  10. SMOS Sea Surface Salinity Validation in the South China Sea (United States)

    Ren, Yongzheng; Li, Xiaoming; Dong, Qing


    In November 2009, the European Space Agency (ESA) launched the first soil moisture and ocean salinity (SMOS) satellite, which represented the first use of spaceborne remote sensing tools to probe global sea surface salinity (SSS). The SMOS satellite carries a microwave imaging radiometer with aperture synthesis (MIRAS) for detection in the microwave L-band as the only payload. The MIRAS instrument is expected to provide a global SSS distribution with a spatial resolution of approximately 100 km and an accuracy of 0.1-0.2 practical salinity units (psu). The South China Sea is semi-enclosed, and the sea conditions are relatively complex. The suitability of ESA SMOS salinity products for the South China Sea has not been validated. Therefore, using SSS data measured during an expedition in the South China Sea, which was sponsored by China Natural Science Foundation and conducted in the fall of 2011, this paper validated the SSS products released by ESA, which were retrieved using three sea surface roughness models. To analyze the effect of the spatial resolution on the weekly average SMOS SSS distribution, the weekly average salinity data were averaged to reduce the spatial resolution to 0.25 ° x 0.25°. These average data were then compared to the measured data, followed by an analysis of the error variation. In addition, the effects of the orbital track (ascending or descending) on the SSS retrieval were analyzed.

  11. Molecular characterization and expression of AMP-activated protein kinase in response to low-salinity stress in the Pacific white shrimp Litopenaeus vannamei. (United States)

    Xu, Chang; Li, Erchao; Xu, Zhixin; Wang, Shifeng; Chen, Ke; Wang, Xiaodan; Li, Tongyu; Qin, Jian G; Chen, Liqiao


    AMP-activated protein kinase (AMPK) serves as a major regulator of cellular energy metabolism by activating ATP production pathways and blocking ATP consumption. However, information on AMPK genes in aquatic animals is limited. In this study, three subunits of AMPK were cloned from the Pacific white shrimp Litopenaeus vannamei. The full-length cDNAs of the α, β and γ subunits were 1617, 1243 and 3467bp long, respectively, with open reading frames of 1566, 873 and 2988bp encoding for 521, 290 and 996 amino acids, respectively. Amino acid sequence alignments of the three subunits showed that the functional domains in the L. vannamei proteins retained the highest similarity with those of other animals, at 89%, 58%, and 75%, respectively. The expression levels of the three subunits were higher in the muscle and gills than in the eyestalk and hepatopancreas. The mRNA levels of AMPK-α and AMPK-β were up-regulated in the hepatopancreas and muscle after acute low-salinity stress at 3psu for 6h compared with control salinity at 20psu. After 8-week salinity stress at 3psu, AMPK-α and AMPK-β mRNA levels in the hepatopancreas were significantly higher than those of the control at 30psu. However, in the muscle only AMPK-γ mRNA was significantly up-regulated at low salinity relative to controls. Muscle and hepatopancreas showed increases in AMPK protein after 6h exposure to low salinity, but there were no differences seen after long term acclimation. The change patterns of protein were slightly differing from the mRNA patterns due to the distinguishing function of individual subunits of AMPK. These findings confirm that three AMPK subunits are present in L. vannamei and that all encode proteins with conserved functional domains. The three AMPK subunits are all regulated at the transcriptional and protein levels to manage excess energy expenditure during salinity stress.

  12. Effects of low salinity on the growth and survival of Babylonia lutosa juveniles%低盐度对泥东风螺(Babylonia lutosa)稚螺生长与存活的影响

    Institute of Scientific and Technical Information of China (English)

    郑雅友; 苏新红; 曾志南; 刘波; 李正良; 李雷斌


    We applied two methods of acute and gradual salinity changes in our experiment to explore effects on the growth and survival of Babylonia lutosa juveniles. The average weight was 3.7mg and the average shell-height was (2.24 ± 0.24)mm. The results showed that the juveniles grew fastest in salinity 28. Abnormal juveniles of Babylonia lutosa could adapt to the low salinity environment which with higher survival rates than those in salinity 21.The feeding,growth and survival of Babylonia lutosa juveniles were normal under salinity 21 condition. When acute salinity became 18,Babylonia lutosa juveniles could still survive but suffer severe influence on feeding and growth. Those juveniles could not survive when acute salinity change under 15 but gradual salinity change could do with severe influence on feeding and growth. In conclusion,the survival range of Babylonia lutosa juveniles would be wider with gradual salinity change,but the adaptable growth range was limited.%采用盐度渐变和突变2种方法试验低盐度对平均体重3.7 mg、平均壳高(2.24±0.24) mm的泥东风螺稚螺生长与存活的影响。结果表明:盐度28时,稚螺的生长速度最快,盐度降到24时,对稚螺的影响并不明显,摄食基本正常,但活力略有降低;变态7 d的泥东风螺稚螺能够适应高于21的低盐环境,存活基本正常,有比较高的成活率,但对其摄食和生长有一定的影响;当盐度突变至18时,泥东风螺稚螺仍能存活,突变至15时,则不能存活;而盐度渐变至15时,稚螺仍可存活;盐度逐渐降低只可扩大泥东风螺稚螺的存活盐度范围,但其对最适生长盐度范围影响有限。

  13. Salinity tolerance of non-native suckermouth armoured catfish (Loricariidae: Pterygoplichthys) in south-eastern Mexico: implications for invasion and dispersal (United States)

    Capps, Krista A.; Nico, Leo G.; Mendoza-Carranza, Manuel; Arevalo-Frias, Wendi; Ropicki, Andrew J.; Heilpern, Sebastian A.; Rodiles-Hernandez, Rocio


    1. Salinity tolerance is one of several important physiological attributes that determine invasion success and the pattern of dispersal of introduced aquatic organisms. Introduced freshwater fishes able to tolerate elevated salinities have the potential to invade and exploit brackish-water (mixohaline) environments and use estuaries and coastal waters as 'bridges' for dispersing from one coastal river system to another. 2. Several members of the neotropical suckermouth armoured catfish genus Pterygoplichthys (Siluriformes: Loricariidae) have established non-native populations in inland waters of North and Central America, Asia and islands in the Caribbean, and Pacific and Indian oceans. Loricariids are generally considered to be strictly freshwater; but a few naturally occur in mesohaline habitats. 3.Catch and habitat data from 2004–2005 and 2009–2011 fish surveys in the Grijalva–Usumacinta River delta region (south-eastern Mexico) confirmed that introduced Pterygoplichthys populations established in upstream freshwater sites (where these catfish are abundant) have recently dispersed into downstream oligohaline and mesohaline estuarine habitats. During 2009–2011 surveys, these non-native catfish — tentatively identified as P. pardalis or its hybrids — were found in sites with salinities ranging from 1 to 8 ppt (mean 5.2 ppt). 4.Acute-salinity experiments were conducted with Pterygoplichthys (110–302 mm standard length, N=140) captured in the Grijalva–Usumacinta Basin to determine upper salinity tolerance levels. Tests demonstrated that individuals maintained in salinities of 0.2 ppt were able to survive abrupt (acute) exposure to salinities up to 10 ppt with little mortality over 10 days (240 h experimental endpoint). A few individuals survived abrupt exposure to 11 and 12 ppt for 20 or more hours, although none survived more than a few hours at 16 ppt or greater. 5.These field and experimental results provide quantitative evidence that non

  14. Novel water filtration of saline water in the outermost layer of mangrove roots (United States)

    Kim, Kiwoong; Seo, Eunseok; Chang, Suk-Kyu; Park, Tae Jung; Lee, Sang Joon


    The scarcity of fresh water is a global challenge faced at present. Several desalination methods have been suggested to secure fresh water from sea water. However, conventional methods suffer from technical limitations, such as high power consumption, expensive operating costs, and limited system durability. In this study, we examined the feasibility of using halophytes as a novel technology of desalinating high-concentration saline water for long periods. This study investigated the biophysical characteristics of sea water filtration in the roots of the mangrove Rhizophora stylosa from a plant hydrodynamic point of view. R. stylosa can grow even in saline water, and the salt level in its roots is regulated within a certain threshold value through filtration. The root possesses a hierarchical, triple layered pore structure in the epidermis, and most Na+ ions are filtered at the first sublayer of the outermost layer. The high blockage of Na+ ions is attributed to the high surface zeta potential of the first layer. The second layer, which is composed of macroporous structures, also facilitates Na+ ion filtration. This study provides insights into the mechanism underlying water filtration through halophyte roots and serves as a basis for the development of a novel bio-inspired desalination method.

  15. Charophytes, indicators for low salinity phases in North African sebkhet (United States)

    Soulié-Märsche, Ingeborg


    Among water plants of lakes and ponds, the charophytes are useful for palaeolimnology because they provide autochthonous fossils in the form of their calcified fructifications, termed gyrogonites. Particular species of the Characeae are adapted to brackish water and serve as a modern analogue to infer the salinity of salt lake sediments. Here we focus on Lamprothamnium papulosum whose significance in terms of palaeo-salinity is reviewed with particular attention to the ecological requirements for calcification. New data describe the finding of L. papulosum from Holocene sediments at Sebkha Mellala, Algeria. Previous Quaternary records of this species from North Africa (Mauritania, Libya (Fezzan), Sudan, Mali and Morocco) are discussed in terms of their significance for palaeolimnology. The present paper highlights the potential of fossil charophyte gyrogonites as indicators of former low salinity phases in present-day hypersaline environments.

  16. On the effectiveness of dry drainage in soil salinity control

    Institute of Scientific and Technical Information of China (English)

    WU JingWei; ZHAO LiRong; HUANG JieSheng; YANG JinZhong; VINCENT Bernard; BOUARFA Sami; VIDAL Alain


    Dry drainage is thought to be a potential approach to control soil salinity.This study took the Hetao Irrigation District as an example and evaluated the effectiveness of dry drainage by using remote sensing, a conceptual model and a field experiment.Archived remote sensing images from 1973-2006 were used to delineate the temporal and spatial change of soil salinity.The conceptual water and salt balance model was used to evaluate the role of dry drainage in removing excess salt from the irrigated land.The field experiment was performed to get field validation and give more accurate estimation.The results show that dry drainage did contribute to remove excess salt from the irrigated land and succeed in controlling soil salinity in the Hetao Irrigation can be taken as an alternative approach in (semi-)arid area where artificial drainage is not applicable.

  17. On the effectiveness of dry drainage in soil salinity control

    Institute of Scientific and Technical Information of China (English)

    VINCENT; Bernard; BOUARFA; Sami; VIDAL; Alain


    Dry drainage is thought to be a potential approach to control soil salinity. This study took the Hetao Irrigation District as an example and evaluated the effectiveness of dry drainage by using remote sensing, a conceptual model and a field experiment. Archived remote sensing images from 1973―2006 were used to delineate the temporal and spatial change of soil salinity. The conceptual water and salt balance model was used to evaluate the role of dry drainage in removing excess salt from the irrigated land. The field experiment was performed to get field validation and give more accurate estimation. The results show that dry drainage did contribute to remove excess salt from the irrigated land and succeed in controlling soil salinity in the Hetao Irrigation District. It can be taken as an alternative approach in (semi-)arid area where artificial drainage is not applicable.

  18. Climate change impacts on water salinity and health. (United States)

    Vineis, Paolo; Chan, Queenie; Khan, Aneire


    It is estimated that 884 million people do not have access to clean drinking water in the world. Increasing salinity of natural drinking water sources has been reported as one of the many problems that affect low-income countries, but one which has not been fully explored. This problem is exacerbated by rising sea-levels, owing to climate change, and other contributing factors, like changes in fresh water flow from rivers and increased shrimp farming along the coastal areas. In some countries, desalination plants are used to partly remove salt and other minerals from water sources, but this is unlikely to be a sustainable option for low-income countries affected by high salinity. Using the example of Bangladesh as a model country, the following research indicates that the problem of salinity can have serious implications with regard to rising rates of hypertension and other public health problems among large sectors of the worldwide population.

  19. Thermal, Electrical, and Optical Measurements of Electrical Discharges in Saline (United States)

    Moore, Cameron; Ward, Arlen; Sato, Kazunari; Collins, George


    We report measurements of electrical discharges in saline that are electrically excited at 100 kHz from a commercial electrosurgical system. Using a one-dimensional thermocouple array, we estimate that these discharges in saline, in contrast to prior work, induce local temperatures > 100 C. Simultaneous measurement of voltage, current, and optical emission of Na* at 589 nm show that these discharges have frequent arcs, and that these arcs dominate energy flow into the saline. Finally we present measurements of Stark splitting of the sodium D1 and D2 resonant emission lines and from these data estimate the thickness of sheath-like region where most of the applied voltage is dropped.

  20. Groundwater salinity in a floodplain forest impacted by saltwater intrusion. (United States)

    Kaplan, David A; Muñoz-Carpena, Rafael


    Coastal wetlands occupy a delicate position at the intersection of fresh and saline waters. Changing climate and watershed hydrology can lead to saltwater intrusion into historically freshwater systems, causing plant mortality and loss of freshwater habitat. Understanding the hydrological functioning of tidally influenced floodplain forests is essential for advancing ecosystem protection and restoration goals, however finding direct relationships between hydrological inputs and floodplain hydrology is complicated by interactions between surface water, groundwater, and atmospheric fluxes in variably saturated soils with heterogeneous vegetation and topography. Thus, an alternative method for identifying common trends and causal factors is required. Dynamic factor analysis (DFA), a time series dimension reduction technique, models temporal variation in observed data as linear combinations of common trends, which represent unexplained common variability, and explanatory variables. DFA was applied to model shallow groundwater salinity in the forested floodplain wetlands of the Loxahatchee River (Florida, USA), where altered watershed hydrology has led to changing hydroperiod and salinity regimes and undesired vegetative changes. Long-term, high-resolution groundwater salinity datasets revealed dynamics over seasonal and yearly time periods as well as over tidal cycles and storm events. DFA identified shared trends among salinity time series and a full dynamic factor model simulated observed series well (overall coefficient of efficiency, Ceff=0.85; 0.52≤Ceff≤0.99). A reduced multilinear model based solely on explanatory variables identified in the DFA had fair to good results (Ceff=0.58; 0.38≤Ceff≤0.75) and may be used to assess the effects of restoration and management scenarios on shallow groundwater salinity in the Loxahatchee River floodplain.