WorldWideScience

Sample records for acute herpes zoster

  1. Herpes zoster and diabetes.

    Science.gov (United States)

    Kalra, Sanjay; Chawla, Aastha

    2016-08-01

    This review is a succinct description of the relationship between herpes zoster and diabetes. It makes a strong case for screening for diabetes in all patients of herpes zoster, and for using insulin to achieve optimal glycaemic control in persons with concomitant diabetes and herpes zoster. It highlights potential impact of dipeptidyl peptidase 4 inhibitor therapy and statin usage on herpes zoster incidence.

  2. Typical case: herpes zoster

    Directory of Open Access Journals (Sweden)

    Guilherme Cristianini Baldivia

    2015-04-01

    Full Text Available Summary The varicella zoster virus is the causative agent of herpes zoster and varicella. In herpes zoster, the virus dormant within dorsal root ganglia is reactivated, resulting in painful vesicular lesions overlying an erythematous base.

  3. Shingles (Herpes Zoster)

    Science.gov (United States)

    ... a painful, blistering rash. Shingles: Overview Also called herpes zoster Anyone who has had chickenpox can get shingles. ... involve the eye are called ocular shingles or herpes zoster ophthalmicus. Signs and symptoms of shingles in the ...

  4. Herpes zoster (shingles) disseminated (image)

    Science.gov (United States)

    Herpes zoster (shingles) normally occurs in a limited area that follows a dermatome (see the "dermatome" picture). In individuals with damaged immune systems, herpes zoster may be widespread (disseminated), causing serious illness. Herpes ...

  5. Herpes Zoster Ophthalmicus.

    Science.gov (United States)

    Johnson, Julie L; Amzat, Rianot; Martin, Nicolle

    2015-09-01

    Herpes zoster is a commonly encountered disorder. It is estimated that there are approximately 1 million new cases of herpes zoster in the United States annually, with an incidence of 3.2 per 1000 person-years. Patients with HIV have the greatest risk of developing herpes zoster ophthalmicus compared with the general population. Other risk factors include advancing age, use of immunosuppressive medications, and primary infection in infancy or in utero. Vaccination against the virus is a primary prevention modality. Primary treatments include antivirals, analgesics, and anticonvulsants. Management may require surgical intervention and comanagement with pain specialists, psychiatrists, and infectious disease specialists.

  6. The Uncommon Localization of Herpes Zoster

    OpenAIRE

    Cukic, Vesna

    2016-01-01

    Introduction: Herpes zoster is an acute, cutaneous viral infection caused by the reactivation of varicella-zoster virus (VZV) that is the cause of varicella. It is an acute neurological disease which can often lead to serious postherpetic neuralgia (PHN). Different nerves can be included with the skin rash in the area of its enervation especially cranial nerves (CV) and intercostal nerves. Case report: In this report we present a patient with herpes zoster which involved ulnar nerve with skin...

  7. Herpes zoster infection

    Directory of Open Access Journals (Sweden)

    Mohit Bansal

    2012-01-01

    Full Text Available Herpes zoster (HZ or ′shingles′ results from reactivation of the varicella-zoster virus (VZV. Developmental anomalies, osteonecrosis of jaw bones, and facial scarring are the other complications associated with it. Primary VZV infections in sero-negative individuals are known as varicella or chicken pox. Secondary or reactivated disease is known as shingles or herpes zoster. Early diagnosis and prompt treatment of the disease in the prodromal phase by the use of antiviral agents should be the mainstay of its management. This paper presents a case report of such an infection and its management.

  8. Acute pancreatitis associated with herpes zoster: case report and literature review.

    Science.gov (United States)

    Wang, Zhen; Ye, Jun; Han, Yue-Hua

    2014-12-21

    Varicella-zoster virus (VZV) is a type of herpes virus known to cause varicella, mainly in young children, and herpes zoster in adults. Although generally non-lethal, VZV infection can be associated with serious complications, particularly in adults. Acute pancreatitis caused by VZV infection is a rare event, with reports primarily concerning immunocompromised individuals. Here we report a 44-year-old immunocompetent female who developed acute pancreatitis associated with VZV infection. The patient presented with vomiting and persistent pain in the upper quadrant less than one week after diagnosis and treatment for a herpes zoster-related rash with stabbing pain on the abdomen and dorsal right trunk side. A diagnosis of acute pancreatitis was confirmed based on abdominal pain, elevated levels of urine and serum amylase, and findings of peri-pancreatic exudation and effusions by computed tomography and magnetic resonance cholangiopancreatography. This case highlights that, though rare, acute pancreatitis should be considered in VZV patients who complain of abdominal pain, especially in the epigastric area. Early detection and proper treatment are needed to prevent the condition from deteriorating further and to minimize mortality.

  9. High Risk of Herpes Zoster among Patients with Advance Acute Kidney Injury--A Population-Based Study.

    Science.gov (United States)

    Yang, Wei-Shun; Hu, Fu-Chang; Chen, Meng-Kan; Ko, Wen-Je; Chen, Likwang; Wu, Kwan-Dun; Wu, Vin-Cent

    2015-09-03

    The risk for herpes zoster (HZ) in acute kidney injury (AKI) survivors was never explored. We identified 2,387 adults in the Taiwan National Health Insurance Research Database who recovered from dialysis-requiring AKI and matched them with non-recovery and non-AKI patients by propensity score. During a mean follow-up of 2.7 years, the incidences of HZ were 6.9, 8.2 and 4.8 episodes per 1,000 person-years in AKI-non-recovery, AKI-recovery and non-AKI group, respectively. The recovery group was more likely to develop herpes zoster than those without acute kidney injury [incidence-rate ratios 1.71, 95% confidence interval 1.16-2.52; p = 0.007]. Patients without acute kidney injury were less likely to develop herpes zoster than those AKI, recovered from dialysis or not (hazard ratio HR 0.66, 95% CI 0.46-0.95). Dialysis-requiring acute kidney injury poses a long-term risk of herpes zoster after hospital discharge. Even patients who have recovered from dialysis still carry a significantly higher risk of developing herpes zoster.

  10. Atypical presentation of herpes zoster in a case with acute myeloblastic leukemia

    Institute of Scientific and Technical Information of China (English)

    Fesih Aktar; Sinan Akbayram; Necmettin Akdeniz; Sirac Aktar; Cihangir Akgn; Murat Doan; Hseyin aksen; Ahmet Faik Oner

    2013-01-01

    Herpes zoster (HZ) is often associated with painful erythematous vesicular eruptions of the skin or mucous membranes. Approximately 10% to 30% of the population will suffer from HZ during their lifetime. HZ is infrequent in healthy children. However, diminished cellular immunity seems to increase risk of reactivation because incidence increases with age and in immunocompromised states. We report a 7-year-old girl with acute myeloblastic leukemia HZ infection on the right palmar, elbow and forearm region (C7, C8 and T1 dermatomes). We want to indicate unusual localization of HZ on the acute myeloblastic leukemia child patient.

  11. The Uncommon Localization of Herpes Zoster

    Science.gov (United States)

    Cukic, Vesna

    2016-01-01

    Introduction: Herpes zoster is an acute, cutaneous viral infection caused by the reactivation of varicella-zoster virus (VZV) that is the cause of varicella. It is an acute neurological disease which can often lead to serious postherpetic neuralgia (PHN). Different nerves can be included with the skin rash in the area of its enervation especially cranial nerves (CV) and intercostal nerves. Case report: In this report we present a patient with herpes zoster which involved ulnar nerve with skin rash in the region of ulnar innervations in women with no disease previously diagnosed. The failure of her immune system may be explained by great emotional stress and overwork she had been exposed to with neglecting proper nutrition in that period. Conclusion: Herpes zoster may involve any nerve with characteristic skin rash in the area of its innervations, and failure in immune system which leads reactivation of VZV may be caused by other factors besides the underlying illness. PMID:26980938

  12. Herpes Zoster Vaccination: Controversies and Common Clinical Questions.

    Science.gov (United States)

    Van Epps, Puja; Schmader, Kenneth E; Canaday, David H

    2016-01-01

    Herpes zoster, clinically referred to as shingles, is an acute, cutaneous viral infection caused by reactivation of the varicella zoster virus, the same virus that causes chickenpox. The incidence of herpes zoster and its complications increase with decline in cell-mediated immunity, including age-associated decline. The most effective management strategy for herpes zoster is prevention of the disease through vaccination in those who are most vulnerable. Despite the demonstrated efficacy in reducing the incidence and severity of herpes zoster, the uptake of vaccine remains low. Here, we will discuss the controversies that surround the live herpes zoster vaccine and address the common clinical questions that arise. We will also discuss the new adjuvanted herpes zoster vaccine currently under investigation.

  13. Efficacy of low dose gabapentin in acute herpes zoster for preventing postherpetic neuralgia: a prospective controlled study.

    Science.gov (United States)

    Lee, Eo G; Lee, Hee J; Hyun, Dong J; Min, Kyunghoon; Kim, Dong H; Yoon, Moon S

    2016-05-01

    Postherpetic neuralgia (PHN) is a sequela of herpes zoster that adversely affects quality of life seriously. The risk factors for PHN are well known but the effective interventions that reduce the incidence of PHN are less studied. The objective of this study is to evaluate the efficacy of treatment with gabapentin in patients with acute herpes zoster for preventing PHN. We performed a prospective randomized controlled study of 120 participants diagnosed with acute herpes zoster, aged 50 and over and complaining moderate to severe pain. All patients were treated with valacyclovir and acetaminophen. Half of the participants were assigned to the gabapentin group and received gabapentin 300 mg three times a day additionally. The intensity of pain at every visit and the incidence of PHN in both groups were measured. Total 52 and 49 patients in the gabapentin group and the control group, respectively, had completed 12 weeks of follow-up period. Although the incidence of PHN was higher in the control group, the difference was not statistically significant (6.1% vs. 3.8%, p = 0.67). Our results indicate that the use of low-dose gabapentin in acute herpes zoster seems not effective in the prevention of PHN.

  14. Transient Receptor Potential Vanilloid-1 in Epidermal Keratinocytes May Contribute to Acute Pain in Herpes Zoster.

    Science.gov (United States)

    Han, Sang Bum; Kim, Hyeree; Cho, Sang Hyun; Lee, Jeong Deuk; Chung, Jin Ho; Kim, Hei Sung

    2016-03-01

    The role of transient receptor potential vanilloid-1 (TRPV1) in the initiation of neurogenic inflammation and transduction of pain is well established. In this study 33 patients with herpes zoster (HZ) were recruited from a single centre and underwent a questionnaire interview at their first visit. Punch biopsies from the HZ lesions and the contralateral unaffected skin were performed to localize and quantify the expression of TRPV1. Immunofluorescent staining for TRPV1 was most prominent in the epidermal keratinocytes. Both TRPV1 mRNA and protein levels were significantly higher in the HZ epidermis than in control epidermis (relative ratio 1.62 ± 0.27, p = 0.033 and 2.55 ± 0.51, p = 0.005, respectively). Protein TRPV1 ratio (HZ lesion/control) correlated with the degree of pain (measured on a visual analogue scale; VAS) (p = 0.017) and was significantly lower in patients who had taken either HZ medication or painkillers prior to their visit. These results suggest that non-neuronal TRPV1 may contribute to acute pain in herpes zoster.

  15. Ramsay hunt syndrome (herpes zoster oticus

    Directory of Open Access Journals (Sweden)

    S Karthiga Kannan

    2012-01-01

    Full Text Available Ramsay Hunt syndrome (RHS is defined as an acute peripheral facial neuropathy caused by the reactivated latent varicella zoster virus (VZV in the geniculate ganglion; characterized with erythematous vesicular rash of the skin of the ear canal, auricle, facial skin, oral mucosa and facial palsy (also known as herpes zoster oticus. This article reports a case of Ramsay Hunt Syndrome (RHS in a 37-year-old male patient depicting the classical signs.

  16. [Herpes zoster and postherpetic neuralgia].

    Science.gov (United States)

    Wollina, U; Machetanz, J

    2016-08-01

    Herpes zoster develops by endogenous reactivation of varizella zoster virus (VZV). Incidence increases with age. Females are more frequently affected than males. The reactivation rate in seropositive individuals is about 20 %. After a short prodromal stage, herpetiform-grouped vesicles appear in segmental arrangement. Pain and paresthesia are typical zoster symptoms. Complications like bacterial superinfections, vasculopathy, paresis, and oculopathy may occur. During pregnancy herpes zoster is a threat for mother and child. Among elderly patients, cardiovascular risk is increased during the first week of herpes zoster infection. Postherpetic neuropathy is feared. Diagnosis can be made clinically and by the use of polymerase chain reaction. First-line treatment is systemic antiviral drug therapy with either acyclovir or brivudine. Adjuvant therapies consist of pain management and topical treatment.

  17. Herpes zoster: A clinicocytopathological insight

    Directory of Open Access Journals (Sweden)

    Snehal Shah

    2016-01-01

    Full Text Available Herpes zoster or shingles is reactivation of the varicella zoster virus that had entered the cutaneous nerve endings during an earlier episode of chicken pox traveled to the dorsal root ganglia and remained in a latent form. This condition is characterized by occurrence of multiple, painful, unilateral vesicles and ulceration which shows a typical single dermatome involvement. In this case report, we present a patient with herpes zoster involving the mandibular division of the trigeminal nerve, with unilateral vesicles over the right side of lower third of face along the trigeminal nerve tract, with intraoral involvement of buccal mucosa, labial mucosa and the tongue of the same side. Cytopathology revealed classic features of herpes infection including inclusion bodies, perinuclear halo and multinucleated cells.

  18. Correlation of serum inflammatory cytokine and immunoglobulin content with post-herpetic neuralgia in patients with acute herpes zoster

    Institute of Scientific and Technical Information of China (English)

    Hai-Jun Shi; Zhi-Qiang Cui

    2017-01-01

    Objective:To study the correlation of serum inflammatory cytokine and immunoglobulin content with post-herpetic neuralgia in patients with acute herpes zoster.Methods:Patients diagnosed with herpes zoster in our hospital between May 2012 and October 2015 were selected and divided into herpes zoster-post-herpetic neuralgia group (VZV-PHN group) and herpes zoster-control group (VZV-Con group) according to the incidence of post-herpetic neuralgia (PHN); healthy volunteers receiving physical examination in our hospital during the same period were selected as normal control group (Con group).Results: Serumβ-EP, NT, IFN-γ and IL-2 levels of VZV-PHN group and VZV-Con group were significantly lower than those of Con group (P<0.05), while SP, VGF, CGRP, IL-4, IL-6, IL-17, IL-21, TNF-α, IL-10, TGF-β1, IgG, IgM and IgA levels were significantly higher than those of Con group (P<0.05); serumβ-EP, NT, IFN-γ, IL-2, IgG, IgM and IgA levels of VZV-PHN group were significantly lower than those of VZV-Con group (P<0.05) while SP, VGF, CGRP, IL-4, IL-6, IL-17, IL-21, TNF-α, IL-10 and TGF-β1 levels were significantly higher than those of VZV-Con group (P<0.05);β-EP and NT were positively correlated with IFN-γ, IL-2, IgG, IgM and IgA, and negatively correlated with IL-4, IL-6, IL-17, IL-21, TNF-α, IL-10 and TGF-β1; SP, VGF and CGRP were negatively correlated with IFN-γ, IL-2, IgG, IgM and IgA, and positively correlated with IL-4, IL-6, IL-17, IL-21, TNF-α, IL-10 and TGF-β1.Conclusions:Abnormal secretion of inflammatory cytokines and immunoglobulin caused by humoral immune and cellular immune response disorder is associated with the occurrence of post-herpetic neuralgia in patients with acute herpes zoster.

  19. Acute Cardiovascular Events after Herpes Zoster: A Self-Controlled Case Series Analysis in Vaccinated and Unvaccinated Older Residents of the United States.

    Directory of Open Access Journals (Sweden)

    Caroline Minassian

    2015-12-01

    Full Text Available Herpes zoster is common and can have serious consequences. Additionally, emerging data suggest an increased risk of acute cardiovascular events following herpes zoster. However, to our knowledge, existing association studies compare outcomes between individuals and are therefore vulnerable to between-person confounding. In this study, we used a within-person study design to quantify any short-term increased risk of acute cardiovascular events (stroke and myocardial infarction [MI] after zoster and to assess whether zoster vaccination modifies this association.The self-controlled case series method was used to estimate rates of stroke and acute MI in defined periods after herpes zoster compared to other time periods, within individuals. Participants were fully eligible Medicare beneficiaries aged ≥ 65 y with a herpes zoster diagnosis and either an ischemic stroke (n = 42,954 or MI (n = 24,237 between 1 January 2006 and 31 December 2011. Age-adjusted incidence ratios (IRs for stroke and MI during predefined periods up to 12 mo after zoster relative to unexposed time periods were calculated using conditional Poisson regression. We observed a marked increase in the rate of acute cardiovascular events in the first week after zoster diagnosis: a 2.4-fold increased ischemic stroke rate (IR 2.37, 95% CI 2.17-2.59 and a 1.7-fold increased MI rate (IR 1.68, 95% CI 1.47-1.92, followed by a gradual resolution over 6 mo. Zoster vaccination did not appear to modify the association with MI (interaction p-value = 0.44. We also found no evidence for a difference in the IR for ischemic stroke between vaccinated (IR 1.14, 95% CI 0.75-1.74 and unvaccinated (IR 1.78, 95% CI 1.68-1.88 individuals during the first 4 wk after zoster diagnosis (interaction p-value = 0.28. The relatively few vaccinated individuals limited the study's power to assess the role of vaccination.Stroke and MI rates are transiently increased after exposure to herpes zoster. We found no

  20. Report of a child with acute herpes zoster ophthalmicus induced partial third nerve palsy

    Institute of Scientific and Technical Information of China (English)

    Suraida AR; Evelyn-Tai LM; Madhusudhan; LK Thavaratnam; Mohtar Ibrahim; Wan Hazabbah WH

    2015-01-01

    Herpes zoster is a reactivation of the varicella zoster virus (VZV), which may remain dormant in the dorsal root ganglion of the trigeminal nerve for decades after the patient's initial exposure. The ophthalmic branch of the trigeminal nerve, i.e., the innervation to the ocular structures, is one of the most commonly involved dermatomes, giving rise to herpes zoster ophthalmicus (HZO). A 10-year-old indigenous Malaysian girl presented with a complaint of painful blurring of vision in the right eye for one week. It was followed a few days later by cutaneous vesicular eruptions over the right side of her face and nose and drooping of the right upper lid, associated with double vision. In children, the disease usually follows a mild course, resolving without residual damage. However, this child achieved a best corrected visual acuity of only 6/36 in the affected eye due to corneal scarring. The rashes healed by formation of disfiguring keloids over the right nasal area. This is another rarely reported complication of HZO in immunocompetent individuals.

  1. An updated approach to treating and preventing herpes zoster.

    Science.gov (United States)

    Garrubba, Carl; Donkers, Kelly

    2013-12-01

    Varicella zoster virus (VZV) causes chickenpox and herpes zoster. Herpes zoster is a common infection in older adults and can lead to potentially debilitating postherpetic neuralgia. This article reviews the diagnosis and management of herpes zoster, including strategies to reduce disease frequency and severity with the herpes zoster vaccine.

  2. Herpes zoster oticus: A rare clinical entity

    Directory of Open Access Journals (Sweden)

    Shailesh Gondivkar

    2010-01-01

    Full Text Available Herpes zoster oticus also known as Ramsay Hunt syndrome is a rare complication of herpes zoster in which reactivation of latent varicella zoster virus infection in the geniculate ganglion causes otalgia, auricular vesicles, and peripheral facial paralysis. Ramsay Hunt syndrome is rare in children and affects both sexes equally. Incidence and clinical severity increases when host immunity is compromised. Because these symptoms do not always present at the onset, this syndrome can be misdiagnosed. Although secondary to Bell′s palsy in terms of the cause of acute atraumatic peripheral facial paralysis, Ramsay Hunt syndrome, with incidence ranged from 0.3 to 18%, has a worse prognosis. Herpes zoster oticus accounts for about 12% cases of facial palsy, which is usually unilateral and complete and full recovery occurs in only about 20% of untreated patients. The most advisable method to treat Ramsay Hunt syndrome is the combination therapy with acyclovir and prednisone but still not promising, and several prerequisites are required for better results. We present a case of 32-year-old man suffering from Ramsay Hunt syndrome with grade V facial palsy treated effectively with rehabilitation program, after the termination of the combination therapy of acyclovir and prednisone.

  3. Herpes Zoster Ophthalmicus Presenting as Acute Orbital Myositis Preceding a Skin Rash: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Ha Yeun; Cho, Seong Whi [Dept. of Radiology, Kangwon National University Hospital, Chuncheon (Korea, Republic of); Kim, Sung Hun [Dept. of Neurology, Kangwon National University Hospital, Chuncheon (Korea, Republic of)

    2012-03-15

    Herpes zoster ophthalmicus, in which orbital symptoms and signs appear before the onset of a skin rash, is very rare. We experienced such a case and therefore report on it via magnetic resonance imaging. A 48-year-old man with pain and swelling of left eye and headache presented 2 days before onset of a zoster skin rash. On orbit-al MRI, edematous thickening of the left lateral rectus muscle with high signal intensity was revealed. After contrast injection, the lateral rectus muscle demonstrated heterogenous enhancement. Also, diffuse contrast enhancement was noted at left preseptal space, lacrimal gland and periorbital soft tissue. The man was treated with antiviral agents and prednisolone. Two weeks later, he recovered from the skin manifestations and most of the orbital manifestations except for the diplopia and restricted lateral movement.

  4. Immunity and the burden of herpes zoster.

    Science.gov (United States)

    Choi, Won Suk; Kwon, Soon Sun; Lee, Jacob; Choi, Su-Mi; Lee, Jin Soo; Eom, Joong Sik; Sohn, Jang Wook; Choeng, Hee Jin

    2014-03-01

    The burden of herpes zoster may be related to patients' immunity, although this has not been studied extensively. This hypothesis was tested in a matched case-control study of patients with herpes zoster who sought treatment at one of seven university hospitals in Korea from January 1, 2007, to December 31, 2010. Patients diagnosed with herpes zoster were placed into three groups based on their immune status: severely immunocompromised, mild-to-moderately immunocompromised, and normal immunity. Each patient in the severely immunocompromised group was matched with one patient in the mild-to-moderately immunocompromised group and one patient in the normal immunity group in the same hospital based on age, sex, and date of herpes zoster onset. A total of 582 patients with herpes zoster were included in the analysis: 194 in each of the three groups. Patients in the severely immunocompromised group had the highest herpes zoster-related hospitalization rate as compared to patients in the mild-to-moderately immunocompromised and normal immune groups (P herpes zoster-related medical cost increased significantly with the deterioration of patients' immunity (P herpes zoster burden was observed as the patients' immunity decreased. Therefore, effective measures are necessary to prevent herpes zoster and reduce its burden in severely immunocompromised patients.

  5. Herpes zoster post-herpetic neuralgia.

    Science.gov (United States)

    Feller, L; Jadwat, Y; Bouckaert, M

    2005-11-01

    Post-herpetic neuralgia (PHN) is the most frequent complication of herpes zoster and often results in significant morbidity and a reduction in the patient's quality of life. The peripheral nerve injury that occurs during the acute phase of herpes zoster (HZ) leads to an abnormal tonic impulse discharge from primary nociceptive afferent neurons which induce slow temporal summation. This "wind-up" phenomenon is responsible for continuous partial depolarisation of second-order neurons with increased spontaneous impulse discharge and expanded receptive fields within the dorsal horn nociceptive neurons. The abnormal central processing involves the activation of N-methyl-D-aspartate (NMDA) receptors resulting in neuropathic pain, characterized by spontaneous pain, hyperalgesia and allodynia which is typical of PHN. In addition, tonic input from non-nociceptive AB afferent neurons, maintained by sympathetic efferent activity, contribute to the development and maintenance of neuropathic pain in general, and a burning sensation in particular.

  6. Herpes Zoster Ophthalmicus in HIV/AIDS

    Directory of Open Access Journals (Sweden)

    Boateng Wiafe MD MSc

    2003-01-01

    Full Text Available Herpes zoster is a common infection caused by the human herpes virus 3, the same virus that causes chickenpox. It is a member of herpes viridae, the same family as the herpes simplex virus, Epstein- Barr virus, and cytomegalovirus. Herpes zoster ophthalmicus occurs when a latent varicella zoster virus in the trigeminal ganglia involving the ophthalmic division of the nerve is reactivated. Of the three divisions of the fifth cranial nerve, the ophthalmic is involved 20 times more frequently than the other divisions.

  7. Polyneuritis cranialis following herpes zoster

    Directory of Open Access Journals (Sweden)

    Radhakrishna H

    2000-01-01

    Full Text Available Herpes zoster is a common clinical condition involving cranial nerves. We encountered 3 cases in which multiple cranial nerves were involved besides the commoner ones. All the three cases were treated with acyclovir and oral steroids. Recovery of motor function was only partial in all three cases when reviewed 2 months after discharge. The clinical details and a brief review of literature are presented.

  8. Rare Occurrence of Herpes Zoster of Trigeminal Nerve following Extraction of Tooth

    Directory of Open Access Journals (Sweden)

    A. Winnifred Christy

    2015-01-01

    Full Text Available Herpes Zoster also known as Shingles is an acute viral infection which is an extremely painful and incapacitating ailment. It results from the reactivation of the varicella zoster virus. The triggering factors for the onset of an attack of Herpes Zoster include some form of immunosuppression. The diagnosis of Herpes Zoster can be made on proper medical history and a thorough clinical examination. Here is the report of a male patient affected by Herpes Zoster infection which followed after extraction of a lower first molar.

  9. Herpes Zoster in Healthy Children: A Retrospective Study

    Directory of Open Access Journals (Sweden)

    Birgül Tepe

    2016-06-01

    Full Text Available Objective: Herpes zoster is an acute dermatomal viral infection caused by the reactivation of varicella zoster virus. While it is commonly seen among elderly and immunocompromised individuals, it is rare in healthy children. The aim of this study was to evaluate the clinical features, treatment and complications of healthy children with herpes zoster. Methods: Thirty one patients aged between 0-16 years who were admitted to our clinic with the diagnosis of herpes zoster, between January 2014 and December 2014, were evaluated retrospectively for age, gender, month of admission, complaint, history of chickenpox infection or varicella vaccination, triggering factors, dermatomal involvement, complications and treatment. Results: Among 31 patients with diagnosis of herpes zoster, 19 were boys (61.3% and 12 were girls (38.7%. The mean of age was 9.12±4.4 years. Twenty patients had thoracic (64.5%, six had lumbar (19.4% and five had cervical involvements (16.2%. The most frequent symptoms were pruritus and pain, respectively. Six patients were administered topical treatment and 25 patients were treated with both systemic and topical treatments. Complication was not observed. Conclusion: Herpes zoster is also being encountered increasingly in healthy children nowadays. It is benign and generally no complications are observed. Incidence can vary because of geographic and socioeconomic differences like vaccination programs.

  10. Acupuncture Treatment of Herpes Zoster

    Institute of Scientific and Technical Information of China (English)

    胡金生

    2001-01-01

    @@Case History Song××, a male middle school teacher aged 58 years, paid his first visit on August 7, 2000, with the chief complaint of pain in the left hypochondrium for 20 days. The patient stated that he suddenly got a sharp burning pain in the left hypochondrium in mid July. The pain gradually radiated to the upper abdominal area, meanwhile red herpes appeared in the hypochondriac region. He had been diagnosed as having herpes zoster, and treated in several nearby hospitals with fluid infusion and medication. As a result, the herpes partly disappeared. But the sharp burning pain still remained, which could not be relieved by administration of analgetics. The patient was then recommended by his friends for treatment here. The patient used to be in a anxious state of mind, and had a wiry pulse and disorder of the liver-qi. The patients had been disturbed by problems of his students and worried about his aged mother's illness, and had poor sleep. Physical examination showed that the patient had a slightly fat figure and sickly complexion, but was in a clear mind. His blood pressure was 140/90 mmHg, and heart rate 75 times/min. No abnormal signs were found in the heart and lungs. Prominent dark red herpes with obvious local tenderness was found on the skin surface of the left hypochondrium and upper abdome.

  11. Herpes zoster infection: Report of a treated case

    Directory of Open Access Journals (Sweden)

    Kotya Naik Maloth

    2015-01-01

    Full Text Available Herpes zoster (HZ is an acute infectious viral disease result from reactivation of the DNA varicella-zoster virus, which occurs more frequently among older adults and immunocompromised persons. The most common complication of HZ is postherpetic neuralgia, a chronic often debilitating pain condition that can last months or even years. Deaths attributable to zoster are common among immunocompromised persons. Prompt treatment with the antiviral drugs, corticosteroids and analgesics decrease the severity and duration of acute pain from HZ. Here, we report a treated case of HZ in 35-year-old male involving all three branches of the trigeminal nerve without any complication.

  12. A Case of Almost Painless Herpes Zoster Presenting with Symptoms of Cystitis, Penile Numbness, and Acute Vestibular Failure

    Directory of Open Access Journals (Sweden)

    Hussain Al-Sardar

    2013-01-01

    Full Text Available Herpes zoster (shingles is an acute, painful, vesicular, and cutaneous eruption caused by varicella zoster virus, the same virus which causes chicken pox. It is due to the reactivation of the virus which remains dormant in sensory ganglions following chicken pox. It is usually confined to a single dermatome but may involve 2-3 dermatomes. Typically, it is a unilateral lesion which can affect both cranial and peripheral nerves. It is usually a self-limiting disease; however, it may cause significant morbidity especially in the elderly. It is more common in older people and individuals with immunocompromised conditions. Antiviral drugs can shorten the duration and the severity of the illness and need to be started as soon as possible after the appearance of the rash. Gabapentin and tricyclic antidepressant are effective in postherpetic neuralgia. Vaccine can reduce the risk of infection and its associated pain. Typically, it occurs once in a lifetime, but some individuals may have more than one episode.

  13. Herpes Zoster Immunization in Older Adults Has Big Benefits.

    Science.gov (United States)

    Breivik, Harald

    2015-09-01

    A case of acute herpes zoster neuralgia (shingles) in a 78-year-old patient is described. The value and importance of immunizing against herpes zoster to decrease the incidence and severity of both acute herpes zoster neuralgia and postherpetic neuralgia are described. --This report is adapted from paineurope 2015: Issue 1, ©Haymarket Medical Publications Ltd., and is presented with permission. paineurope is provided as a service to pain management by Mundipharma International, Ltd., and is distributed free of charge to health care professionals in Europe. Archival issues can be viewed via the Web site: www.paineurope.com , at which health professionals can find links to the original articles and request copies of the quarterly publication and access additional pain education and pain management resources.

  14. Disseminated Herpes Zoster in Association with HIV

    Directory of Open Access Journals (Sweden)

    Kuchabal D

    2000-01-01

    Full Text Available HIV infected individuals are susceptible to a wide variety of skin manifestations due to profound defect in cell-mediated immunity. We describe 2 patients with Disseminated Herpes Zoster, both the patients has associated HIV infection.

  15. Forebyggelse af herpes zoster med vaccination

    DEFF Research Database (Denmark)

    Kofoed, Kristian; Rønholt, Finn; Gerstoft, Jan

    2011-01-01

    Herpes zoster (HZ) and post-herpetic neuralgia (PHN) are frequently occurring diseases in elderly and in immuno-compromised persons. The live attenuated HZ vaccine boosts an existing immune response, so that the already established varicella-zoster virus infection is kept latent. Vaccination has...

  16. Herpes Zoster and Post-Herpetic Neuralgia

    NARCIS (Netherlands)

    van Wijck, Albert J. M.; Wallace, Mark; Mekhail, Nagy; van Kleef, Maarten

    2011-01-01

    Herpes zoster infection is caused by a reactivation of the latent varicella zoster virus that causes chicken pox. It appears predominantly in older adults whose immunity for the virus has waned. The natural course of the disease is usually favorable, and the symptoms disappear spontaneously within a

  17. Management and Prevention of Herpes Zoster: A Canadian Perspective

    Directory of Open Access Journals (Sweden)

    Guy Boivin

    2010-01-01

    Full Text Available Varicella-zoster virus reactivation leads to herpes zoster – the main complication of which is postherpetic neuralgia (PHN. Rapid antiviral therapy initiated within 72 h of rash onset has been shown to accelerate rash healing, reduce the duration of acute pain and, to some extent, attenuate the development and duration of PHN. Other adjunctive therapies such as analgesics, antidepressants and some anticonvulsants are frequently required in the management of severe PHN. A live, attenuated zoster vaccine has been recently shown to significantly decrease herpes zoster incidence, PHN and the overall burden of illness when administered to adults older than 60 years of age. This new prophylactic modality has been reported to be cost-effective in the Canadian context, especially in the 60- to 75-year-old age group.

  18. Superior orbital fissure syndrome in herpes zoster ophthalmicus.

    LENUS (Irish Health Repository)

    Kirwan, R P

    2012-02-01

    AIM: To report a case of superior orbital fissure syndrome (SOFS) in a patient with herpes zoster ophthalmicus (HZO). MATERIALS AND METHODS: A case report. RESULTS: A 71-year-old male with HZO presented acutely to accident and emergency complaining of right vision loss, double vision and drowsiness. The right visual acuity was counting fingers. There was no relative afferent pupillary defect. He had interstitial keratitis, ptosis, proptosis and total ophthalmoplaegia. The signs indicated HZO complicated by SOFS. Brain imaging and lumbar puncture confirmed the diagnosis of varicella zoster encephalitis. Systemic acyclovir and prednisolone led to recovery of visual acuity and ocular motility in addition to resolution of his proptosis and ptosis. CONCLUSION: SOFS is a rare complication of herpes zoster infection. With the appropriate treatment and follow-up, patients may be reassured that recovery of their visual acuity and ocular motility will occur.

  19. Herpes zoster: klinik, diagnostik og behandling

    DEFF Research Database (Denmark)

    Kofoed, Kristian; Rønholt, Finn; Gerstoft, Jan

    2011-01-01

    Herpes zoster (HZ) is a painful vesicular rash localized to one dermatome. Post-herpetic neuralgia (PHN) is persistent pain three months after the rash started. In recent years several Cochrane reviews and clinical studies on how to treat HZ and PHN have been published. These studies show...

  20. Recurrent Herpes Zoster- A Marker of AIDS

    Directory of Open Access Journals (Sweden)

    Mazumdar Gautam

    2003-01-01

    Full Text Available A 32 year old female presented to us with herpes zoster involving the T 8 to T 10 dermatomes. She had a scar involving the same dermatomes on the other half of the body. Investigations revealed that both the patient and her husband were HIV positive with CD4 cell count less than 200.

  1. HERPES ZOSTER KRURIS DEXTRA: LAPORAN KASUS

    Directory of Open Access Journals (Sweden)

    I Gede Agus Bhakti Suputra

    2014-09-01

    Full Text Available Herpes zoster adalah manifestasi klinis karena reaktivasi virus varisela zoster (VZV. Karakteristik penyakit ini ditandai dengan adanya ruam vesikular unilateral yang berkelompok dengan nyeri yang radikular sekitar dermatom. Dilaporkan kasus seorang laki-laki 45 tahun, diagnosis herpes zoster kruris dextra, gambaran klinis berupa vesikel bergerombol multipel, berbentuk bulat, dengan ukuran 0,3-0,5 cm diatas kulit eritematosus, unilateral, tidak menyilang garis tengah, umur vesikel dalam satu gerombolan sama, tetapi dengan gerombolan yang lain tidak sama, kulit diantara gerombolan normal. Pemeriksaan penunjang tes Tzank, hasilnya negatif dengan tidak ditemukannya sel giant multinukleat. Pengobatan diberikan asiklovir 5x800 mg per hari diminum secara oral selama 7 hari, bedak salisil 1% dan mentol 0,5 % dioleskan dua kali sehari pada lesi kering. Prognosis pasien baik.  

  2. Prophylactic Antiviral Treatment in Recurrent Herpes Zoster: A Case Report

    Directory of Open Access Journals (Sweden)

    Hatice Gamze Bayram

    2011-06-01

    Full Text Available Herpes zoster (HZ occurs in older ages with activation of varicella-zoster virus (VZV which persists in a dormant phase within the dorsal root ganglia. The incidence of HZ in immunosuppressed patients is 20-100 times higher and the clinical progress is more severe than in immunocompetent individuals. A 48-year-old man who had been diagnosed with acute myelocytic leukemia type M3 and had been treated with immunosuppressive agents was admitted to our clinic. The patient was clinically diagnosed as having HZ. He was treated with acyclovir 800 mg five times daily for 7 days. In the consecutive three months, he attended our clinic again with similar complaints. The left cervical (C5, C6 dermatomes were involved at the fourth attack of HZ. Multinucleated giant cells were determined on the Tzanck smear. VZV DNA was detected by polymerase chain reaction (PCR. Treatment with valacyclovir 1 g three times daily for 14 days was prescribed and then, prophylactic treatment with valacyclovir 500 mg two times a day was administered. Although immunosuppressive treatment was continued, no new attacks of herpes zoster occurred. We think that prophylactic antiviral therapy should be initiated in immunosuppressive individuals who have recurrent herpes zoster attacks.

  3. Eye and Periocular Skin Involvement in Herpes Zoster Infection

    Science.gov (United States)

    Kalogeropoulos, Chris D.; Bassukas, Ioannis D.; Moschos, Marilita M.; Tabbara, Khalid F.

    2015-01-01

    Herpes zoster ophthalmicus (HZO) is a clinical manifestation of the reactivation of latent varicella zoster virus (VZV) infection and is more common in people with diminished cell-mediated immunity. Lesions and pain correspond to the affected dermatomes, mostly in first or second trigeminal branch and progress from maculae, papules to vesicles and form pustules, and crusts. Complications are cutaneous, visceral, neurological, ocular, but the most debilitating is post-herpetic neuralgia. Herpes zoster ophthalmicus may affect all the ophthalmic structures, but most severe eye-threatening complications are panuveitis, acute retinal necrosis (ARN) and progressive outer retinal necrosis (PORN) as well. Antiviral medications remain the primary therapy, mainly useful in preventing ocular involvement when begun within 72 hours after the onset of the rash. Timely diagnosis and management of HZO are critical in limiting visual morbidity. Vaccine in adults over 60 was found to be highly effective to boost waning immunity what reduces both the burden of herpes zoster (HZ) disease and the incidence of post-herpetic neuralgia (PHN). PMID:27800502

  4. Forebyggelse af herpes zoster med vaccination

    DEFF Research Database (Denmark)

    Kofoed, Kristian; Rønholt, Finn; Gerstoft, Jan;

    2011-01-01

    Herpes zoster (HZ) and post-herpetic neuralgia (PHN) are frequently occurring diseases in elderly and in immuno-compromised persons. The live attenuated HZ vaccine boosts an existing immune response, so that the already established varicella-zoster virus infection is kept latent. Vaccination has...... been shown to halve the risk of HZ, and the risk of PHN is reduced by two thirds in people = 60 years. The vaccine is approved for persons aged = 50 years. However, the clinical efficacy of the vaccine is best studied in people aged = 60 years. The vaccine has so far not shown any serious side-effects....

  5. Herpes zoster laryngitis accompanied by Ramsay Hunt syndrome.

    Science.gov (United States)

    Lee, Dong Hoon; Yoon, Tae Mi; Lee, Joon Kyoo; Joo, Young Eun; Lim, Sang Chul

    2013-01-01

    The most common presentation of herpes zoster in the head and neck region is called Ramsay Hunt syndrome (RHS), which rarely accompanies multiple cranial neuropathy. Herpes zoster also involves the mucous membrane of the tongue, palate, pharynx, and larynx. Herpes zoster infection of the larynx accompanied by Ramsay Hunt syndrome with cranial polyneuropathy is extremely rare, with only few reported cases in the literature. At the time of this report, a review of the medical literature disclosed 4 reported cases of herpes zoster laryngitis accompanied by Ramsay Hunt syndrome. Herein, we present 2 additional cases and report the clinical outcome of cranial polyneuropathy with a review of the literature.

  6. Herpes zoster in breast cancer patients after radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Dunst, J.; Steil, B.; Furch, S.; Fach, A. [Halle-Wittenberg Univ., Halle (Germany). Dept. of Radiotherapy; Bormann, G.; Marsch, W. [Halle-Wittenberg Univ., Halle (Germany). Dept. of Dermatology

    2000-11-01

    Purpose: We have studied the incidence of herpes zoster in patients with adjuvant radiotherapy for breast cancer with special emphasis on possible correlations with other prognostic factors or survival. Patients and Methods: From 1/1985 through 12/1993, 1 155 breast cancer patients received postoperative radiotherapy with curative intent in our department. After mastectomy 961 patients were irradiated and after breast-preserving treatment 194 patients. The age ranged from 34 to 79 years, the median follow-up was 3.1 years (range: 0.3 to 12.4 years). There were 443 women (38%) pre- and 712 (62%) postmenopausal. 21% had T3- to T4-tumors, 55% had axillary lymph node involvement, and 65% received additional systemic hormonal and/or cytotoxic therapy. In case of postmastectomy radiotherapy, the lateral chest wall and lymphatics (axilla, parasternal and supraclavicular nodes) were irradiated with an anterior photon field to 50 Gy (axilla 44 Gy) and most of the chest wall with an electron field to 44 Gy in 2-Gy fractions. After breast-preservation, the breast was irradiated via tangential fields with 6- to 8-MV photons up to 50 Gy plus 8 Gy electron boost to the tumor bed. Most of the patients were followed routinely in the department for 2 to 5 years. The frequency of zoster was determined retrospectively by reviewing the patients' records. Results: A zoster after radiotherapy occurred in 41/1 155 patients (3.7%), mostly within the first 2 years after completion of radiotherapy. All infections remained localized and there was no evidence for systemic infections. Type of treatment (mastectomy vs breast-preservation) had no impact on the frequency of herpes zoster (36/961 patients after mastectomy and 5/194 patients after breast-preservation). There was also no correlation with other prognostic factors such as age, menopausal status, stage of disease or the use of adjuvant chemotherapy, nor was the occurrence of zoster linked to the degree of acute skin reaction in

  7. Herpes Zoster: A Clinicopathologic Correlation with Literature Review

    Directory of Open Access Journals (Sweden)

    N Malathi

    2014-01-01

    Full Text Available Herpes zoster is an acute infectious viral disease of an extremely painful and incapacitating nature. It is characterized by inflammation of dorsal root ganglia or extra medullary cranial nerve ganglia, associated with vesicular eruptions in the areas supplied by the affected nerve. Herewith we report a case of herpes zoster involving two branches—the maxillary and ophthalmic branch of trigeminal nerve. The demonstration of typical viral inclusion bodies by exfoliative cytology from the lesional site aided the rapid diagnosis of the lesion thereby facilitating an early initiation of therapy and improving patient compliance. The article also outlines the history, epidemiology and the natural course of the disease with a discussion of the review of literature.

  8. TREATMENT OF 19 CASES OF HERPES ZOSTER WITH ACUPOINT-INJECTION, ACUPUNCTURE AND MOXIBUSTION

    Institute of Scientific and Technical Information of China (English)

    ZHAO Xiaoyun

    2002-01-01

    @@ Herpes zoster is an acute dermatosis caused by chlckenpox virus inflammation and marked mainly by violent pain and cord-like herpes on the skin surface. In traditional Chinese medicine, it is termed as "She Chuan Chuang"(蛇串疮). The intolerable pain exits in the whole process of the disease even a few weeks or months after disappearance of the herpes, causing the patient to suffer a lot. From April of 1997 to June of 2002, the author adopted acupoint-injection and acupuncture therapies to treat 19 cases of herpes zoster and achieved satisfactory results, here is the report.

  9. Benzalkonium Chloride Intoxication Mimicking Herpes Zoster Encephalitis

    Directory of Open Access Journals (Sweden)

    Ekrem Güler

    2011-06-01

    Full Text Available Benzalkonium chloride (BAC is a frequently used disinfectant and its most well-known side effect is contact dermatitis. In this report, two children who had vesicular dermatitis, headache, lethargy, fever and encephalopathy mimicking Herpes zoster encephalitis were presented. Their consciousness level improved on the second day. From the medical history it was understood that the mother had applied 20% BAC solution to the scalps of two children. The aim of the presentation of this report is to draw attention to the fact that BAC application to the scalp for treating pediculosis capitis may resemble the herpes encephalitis clinical picture.

  10. Mitochondrial Haplogroups as a Risk Factor for Herpes Zoster.

    Science.gov (United States)

    Levinson, Rebecca T; Hulgan, Todd; Kalams, Spyros A; Fessel, Joshua P; Samuels, David C

    2016-10-01

    Background.  Herpes zoster, or shingles, is a common, painful reactivation of latent varicella zoster virus infection. Understanding host factors that predispose to herpes zoster may permit development of more effective prevention strategies. Our objective was to examine mitochondrial haplogroups as a potential host factor related to herpes zoster incidence. Methods.  Study participants were drawn from BioVU, a deoxyribonucleic acid (DNA) biobank connected to deidentified electronic medical records (EMRs) from Vanderbilt University Medical Center. Our study used 9691 Caucasian individuals with herpes zoster status determined by International Classification of Diseases, Ninth Revision codes 053-053.9. Cases and controls were matched on sex and date of birth within 5 years. Mitochondrial haplogroups were defined from mitochondrial DNA variants genotyped on the Illumina 660W or Illumina Infinium Human-Exome Beadchip. Sex and date of birth were extracted from the EMR. Results.  European mitochondrial haplogroup H had a protective association with herpes zoster status (odds ratio [OR] = .82; 95% confidence interval [CI], .71-.94; P = .005), whereas haplogroup clade IWX was a risk factor for herpes zoster status (OR = 1.38; 95% CI, 1.07-1.77; P = .01). Conclusions.  Mitochondrial haplogroup influences herpes zoster risk. Knowledge of a patient's mitochondrial haplogroup could allow for a precision approach to the management of herpes zoster risk through vaccination strategies and management of other modifiable risk factors.

  11. Benzalkonium Chloride Intoxication Mimicking Herpes Zoster Encephalitis

    OpenAIRE

    Güler, Ekrem; Olgar, Şeref; Davutoğlu, Mehmet; Garipardıç, Mesut; Karabiber, Hamza

    2011-01-01

    Benzalkonium chloride (BAC) is a frequently used disinfectant and its most well-known side effect is contact dermatitis. In this report, two children who had vesicular dermatitis, headache, lethargy, fever and encephalopathy mimicking Herpes zoster encephalitis were presented. Their consciousness level improved on the second day. From the medical history it was understood that the mother had applied 20% BAC solution to the scalps of two children. The aim of the presentation of this report is ...

  12. Benzalkonium Chloride Intoxication Mimicking Herpes Zoster Encephalitis

    OpenAIRE

    Ekrem Güler; Şeref Olgar; Mehmet Davutoğlu; Mesut Garipardıç; Hamza Karabiber

    2014-01-01

    Benzalkonium chloride (BAC) is a frequently used disinfectant and its most well-known side effect is contact dermatitis. In this report, two children who had vesicular dermatitis, headache, lethargy, fever and encephalopathy mimicking Herpes zoster encephalitis were presented. Their consciousness level improved on the second day. From the medical history it was understood that the mother had applied 20% BAC solution to the scalps of two children. The aim of the presentation of this report is...

  13. Monoparesis secondary to herpes zoster.

    LENUS (Irish Health Repository)

    Bilal, S

    2011-06-01

    We describe a 90-year-old woman with right upper limb monoparesis secondary to varicella zoster virus infection as a result of extensive inflammatory involvement of the entire brachial plexus at root level. To our knowledge, this is the first report of entire brachial plexus involvement in a living patient of such advanced age. Despite a delay in presentation and thus initiation of treatment, a favourable clinical response was observed.

  14. Update on recommendations for use of herpes zoster vaccine.

    Science.gov (United States)

    Hales, Craig M; Harpaz, Rafael; Ortega-Sanchez, Ismael; Bialek, Stephanie R

    2014-08-22

    Herpes zoster vaccine (Zostavax [Merck & Co., Inc.]) was licensed in 2006 and recommended by the Advisory Committee on Immunization Practices (ACIP) in 2008 for prevention of herpes zoster (shingles) and its complications among adults aged ≥60 years. The Food and Drug Administration (FDA) approved the use of Zostavax in 2011 for adults aged 50 through 59 years based on a large study of safety and efficacy in this age group. ACIP initially considered the use of herpes zoster vaccine among adults aged 50 through 59 years in June 2011, but declined to recommend the vaccine in this age group, citing shortages of Zostavax and limited data on long-term protection afforded by herpes zoster vaccine. In October 2013, ACIP reviewed the epidemiology of herpes zoster and its complications, herpes zoster vaccine supply, short-term vaccine efficacy in adults aged 50 through 59 years, short- and long- term vaccine efficacy and effectiveness in adults aged ≥60 years, an updated cost-effectiveness analysis, and deliberations of the ACIP herpes zoster work group, all of which are summarized in this report. No vote was taken, and ACIP maintained its current recommendation that herpes zoster vaccine be routinely recommended for adults aged ≥60 years. Meeting minutes are available at http://www.cdc.gov/vaccines/acip/meetings/meetings-info.html.

  15. [Clinical presentations of Herpes Zoster Ophthalmicus (diagnosis and therapy)].

    Science.gov (United States)

    Chernakova, G M; Kleshcheva, E A; Semenova, T B

    Approximately a quarter of the world's population at some point in life is at risk of developing shingles (Herpes Zoster). In 10-20% of cases the first branch of the trigeminal nerve gets involved (Herpes Zoster Ophthalmicus, HZO). Ophthalmic complications of HZO are able to cause a significant reduction in visual function.

  16. Clinical and morphological characteristics of herpes zoster in south India

    Directory of Open Access Journals (Sweden)

    Dubey Anand

    2005-01-01

    Full Text Available One hundred and seven cases (6 children and 101 adults of herpes zoster were recruited over a period of two years. The frequency of herpes zoster amongst skin OPD cases was found to be 0.34 per cent. The male to female ratio was 1.74:1. The most common prodromal symptom seen was paresthesia in 25 (23.36% cases followed by itching in 21 (19.62% cases.Most common presenting complaint was pain in 97 (90.65% cases. Ninety nine cases had classical herpes zoster followed by necrotic / ulcerated herpes zoster in 5 cases and hemorrhagic herpes zoster in 3 cases. Thoracic dermatome was the most common dermatome involved in 64 (59.8% cases followed by cervical in 17 (15.8% cases. Unidermatomal involvement was seen in 81 (75.7% cases, followed by multidermatomal in 18 (16.8% cases and disseminated in 8 (7.4% cases. Forty six cases were screened for HIV, out of them; six cases (4 males, 2 females were seropositive for HIV. Classical herpes zoster was a feature in four cases; however, one case each also had necrotic and hemorrhagic form of herpes zoster. To conclude, herpes zoster commonly occurs in young adults in India with presenting symptoms such as pain, itching and fever.

  17. Herpes zoster on the face in the elderly.

    Science.gov (United States)

    Nair, Preeti; Gharote, Harshkant; Singh, Pooja; Jain-Choudhary, Palak

    2014-10-19

    Herpes zoster is a localised disease caused by reactivation of the varicella zoster virus that enters the cutaneous nerve endings during an earlier episode of chicken pox, travels to the dorsal root ganglia, and remains in latent form. The condition is characterised by occurrence of multiple, painful, unilateral vesicles and ulceration, and shows a typical single dermatome innervated by single dorsal root or cranial sensory ganglion. Involvement of three or more dermatomes is known as disseminated zoster and seen in immunocompromised individuals. Complications of herpes zoster include ocular sequelae, bacterial superinfection of the lesions, meningoencephalitis and postherpetic neuralgia. The incidence of herpes zoster increases with age and immunosuppression, therefore prompt management is necessary to avoid morbidity and mortality in these individuals. We present two case reports of herpes zoster, one involving the maxillary and mandibular branches of the trigeminal nerve while the other involves all branches of the trigeminal nerve.

  18. A Rare Complication of Herpes Zoster: Segmental Zoster Paresis

    Directory of Open Access Journals (Sweden)

    Hooi Khee Teo

    2016-01-01

    Full Text Available Herpes zoster is a common presentation in both the community and emergency department; however segmental zoster paresis is a rare complication that can lead to misdiagnosis. We present a case of a 74-year-old Indian gentleman with a background of well controlled diabetes mellitus, hypertension, and ischaemic heart disease who presented with sudden right lower limb weakness. This was preceded by a 5-day history of paraesthesia starting in the right foot and ascending up the right lower limb. On examination, there was a characteristic vesicular rash in the L2/3 region with MRC grading 3/5 in the right hip flexors. The rest of the neurological examination was unremarkable. MRI of the spine did not show any evidence of spinal disease. The patient was initiated on IV acyclovir with improvement of the lower limb weakness to MRC grading 5/5 as the vesicles improved. This is an interesting case as it highlights a rare presentation of zoster: segmental motor paresis that recovered fully with resolution of the rash. It shows the importance of recognizing motor neuropathy as a complication of shingles as it has a very good prognosis with most patients regaining full motor function of the affected limb with treatment.

  19. The epidemiology of varicella and herpes zoster in The Netherlands: implications for varicella zoster virus vaccination.

    NARCIS (Netherlands)

    Melker, Hester E de; Berbers, Guy A M; Hahné, Susan J M; Rümke, Hans; Hof, Susan van den; Wit, G Ardine de; Boot, Hein J

    2006-01-01

    We studied the epidemiology of varicella (chickenpox) and herpes zoster (shingles) in The Netherlands to assess the desirability to implement routine varicella zoster virus vaccination in The Netherlands. Data on seroprevalence of varicella zoster virus in the general population (1995-1996), consult

  20. Diaphragmatic paralysis associated with herpes zoster and HIV-tuberculosis co-infection.

    Science.gov (United States)

    Benabdellah, A; Souhil, Touati; Farouk, Zaoui Omar

    2014-08-01

    Motor complications after herpes zoster are not uncommon. There have been reports of muscular paralysis following herpes zoster. The association between diaphragmatic paralysis and zoster was first reported in 1949 by Halpern. The case presented below showed diaphragmatic involvement following herpes zoster in a HIV-tuberculosis coinfected patient.

  1. A case report of abdominal distention caused by herpes zoster

    Institute of Scientific and Technical Information of China (English)

    Su-Rong Zhou; Chuan-Yu Liu

    2012-01-01

    Gastrointestinal complications caused by herpes zoster are extremely rare.Here,we described a case of abdominal distention caused by herpes zoster.The patient was a 59-year-old female who suffered from unexplained paroxysmal and a burning pain on the right part of her waist and abdomen,accompanied by abdominal distention.Intestinal pseudo-obstruction was diagnosed by abdominal radiography.Distention of the right abdominal wall was still apparent after one month.In this report,we found that recovery from abdominal distention caused by herpes zoster is difficult and may require surgical intervention.

  2. Nutritional factors in herpes zoster, postherpetic neuralgia, and zoster vaccination.

    Science.gov (United States)

    Chen, Jen-Yin; Chang, Chia-Yu; Lin, Yung-Song; Hu, Miao-Lin

    2012-12-01

    Herpes zoster (HZ) results from a reactivation of latent varicella-zoster virus (VZV). HZ and its most common complication, termed postherpetic neuralgia (PHN), often cause long-term psychological distress and physical disabilities leading to profoundly negative impacts on the quality of patients' lives. The incidence and severity of HZ and PHN increase with advanced age as a consequence of declining cell-mediated immunity. Aging has been linked to progressive senescence of the immune system and also is associated with a greater susceptibility to nutritional deficiencies. Suppressing VZV reactivation depends on intact cell-mediated immunity, which requires adequate nutrients to maintain its efficient function. Contrarily, nutritional deficiencies may lead to dysfunction of the host immune responses. Recently, micronutrient deficiencies have been shown to increase the risk of HZ and PHN and to affect the immune response to vaccinations, whereas nutritional supplements effectively reduce herpetic pain and pain in patients with PHN. As the elderly population grows, the incidence and severity of HZ and PHN are expected to increase and cause a substantial financial burden on the health care system. Thus, enhancing knowledge of the risk factors of HZ and PHN and developing better interventions to treat and prevent HZ and PHN are important to public health. This article provides an overview of the present understanding of the association among nutritional deficiencies, diminished cell-mediated immunity, and the risk of HZ and PHN, and then illustrates the potential of nutritional intervention in the prevention, vaccination, and management of HZ and PHN.

  3. Cost-effectiveness of vaccination against herpes zoster

    NARCIS (Netherlands)

    de Boer, Pieter; Wilschut, Jan C.; Postma, Maarten J.

    2014-01-01

    Herpes zoster (HZ) is a common disease among elderly, which may develop into a severe pain syndrome labeled postherpetic neuralgia (PHN). A live-attenuated varicella zoster virus vaccine has been shown to be effective in reducing the incidence and burden of illness of HZ and PHN, providing the oppor

  4. Herpes zoster ophthalmicus associated with abducens palsy

    Directory of Open Access Journals (Sweden)

    Nibrass Chaker

    2014-01-01

    Full Text Available The extraocular muscle palsies associated with herpes zoster ophthalmicus (HZO are transient, self-limiting conditions, usually seen in elderly patients. There are different treatment recommendations for paralytic complications, but prognosis has generally reported to be favorable. A 75-year-old male patient presented with diplopia. Clinical history revealed left facial vesicular eruptions and pain treated by oral aciclovir 1 week following symptom onset. On examination, we observed cicatricial lesions with crusts involving left hemiface, a limitation in abduction of the left eye, and a superficial punctuate keratitis (SPK with decreased visual acuity (4/10. Examination of the right eye was unremarkable. Hess screen test confirmed left six nerve palsy.

  5. Assessment of skin test with varicella-zoster virus antigen for predicting the risk of herpes zoster.

    Science.gov (United States)

    Okuno, Y; Takao, Y; Miyazaki, Y; Ohnishi, F; Okeda, M; Yano, S; Kumihashi, H; Gomi, Y; Maeda, K; Ishikawa, T; Mori, Y; Asada, H; Iso, H; Yamanishi, K

    2013-04-01

    The Shozu Herpes Zoster (SHEZ) Study was designed to clarify the incidence of and predictive and immunological factors for herpes zoster in a defined community-based Japanese population. As part of this series, a total of 5683 residents aged ≥50 years received a varicella-zoster virus (VZV) skin test with VZV antigen, and 48 h later, the erythema and oedema were assessed by measuring the longest diameter. The diameters of both the erythema and oedema decreased with the increasing age of the subject. Sixty-three subjects contracted herpes zoster within a year after receiving the VZV skin test. Analysis of the herpes zoster incidence rate vs. the skin test reaction revealed that the shorter the diameter of erythema or oedema, the greater the likelihood of herpes zoster. These results demonstrated that the VZV skin test is an excellent surrogate marker for predicting the risk of herpes zoster.

  6. Peptic ulcer as a risk factor for postherpetic neuralgia in adult patients with herpes zoster.

    Science.gov (United States)

    Chen, Jen-Yin; Lan, Kuo-Mao; Sheu, Ming-Jen; Tseng, Su-Feng; Weng, Shih-Feng; Hu, Miao-Lin

    2015-02-01

    Postherpetic neuralgia is the most common complication of herpes zoster. Identifying predictors for postherpetic neuralgia may help physicians screen herpes zoster patients at risk of postherpetic neuralgia and undertake preventive strategies. Peptic ulcer has been linked to immunological dysfunctions and malnutrition, both of which are predictors of postherpetic neuralgia. The aim of this retrospective case-control study was to determine whether adult herpes zoster patients with peptic ulcer were at greater risk of postherpetic neuralgia. Adult zoster patients without postherpetic neuralgia and postherpetic neuralgia patients were automatically selected from a medical center's electronic database using herpes zoster/postherpetic neuralgia ICD-9 codes supported with inclusion and exclusion criteria. Consequently, medical record review was performed to validate the diagnostic codes and all pertaining data including peptic ulcer, Helicobacter pylori (H. pylori) infection and ulcerogenic medications. Because no standard pain intensity measurement exists, opioid usage was used as a proxy measurement for moderate to severe pain. In total, 410 zoster patients without postherpetic neuralgia and 115 postherpetic neuralgia patients were included. Multivariate logistic regressions identified 60 years of age and older, peptic ulcer and greater acute herpetic pain as independent predictors for postherpetic neuralgia. Among etiologies of peptic ulcer, H. pylori infection and usage of non-selective nonsteroidal anti-inflammatory drugs were significantly associated with the increased risk of postherpetic neuralgia; conversely, other etiologies were not significantly associated with the postherpetic neuralgia risk. In conclusion, 60 years of age and older, peptic ulcer and greater acute herpetic pain are independent predictors for postherpetic neuralgia in adult herpes zoster patients.

  7. [Pain associated with craniofacial and cervical herpes zoster].

    Science.gov (United States)

    George, B; Lory, C

    2007-10-01

    Ophthalmological and cervical involvement of herpes zoster virus ranks second and third, respectively, in terms of localization frequency. Involvement of the cranial nerves is a particular sign of complications, notably ocular complications, possibly compromising the visual or facial prognosis through involvement of the VIIth nerve, which is responsible for facial paralysis. These types of involvement should be rapidly diagnosed and treated so as to limit these complications. The pain associated with herpes zoster remains frequent and difficult to treat, even if today the criteria for defining postzoster pain is increasingly refined. Antalgic and antiviral treatment should be initiated early, from the very first signs, to attempt to reduce the incidence of this postzoster pain. The risk factors, associated with the development of postzoster pain are age over 50 years, the severity of the skin rash and the intensity of the acute pain, and the existence of a prodromic pain phase before onset. The European Federation of Neurological Societies has recently published guidelines on the pharmacological treatments for postzoster pain. Nerve block treatments remain at a limited evidence level. Patients with postzoster pain should be managed by teams specializing in pain management as soon as conventional treatments fail.

  8. Herpes zoster caused by vaccine-strain varicella zoster virus in an immunocompetent recipient of zoster vaccine.

    Science.gov (United States)

    Tseng, Hung Fu; Schmid, D Scott; Harpaz, Rafael; LaRussa, Philip; Jensen, Nancy J; Rivailler, Pierre; Radford, Kay; Folster, Jennifer; Jacobsen, Steven J

    2014-04-01

    We report the first laboratory-documented case of herpes zoster caused by the attenuated varicella zoster virus (VZV) contained in Zostavax in a 68-year-old immunocompetent adult with strong evidence of prior wild-type VZV infection. The complete genome sequence of the isolate revealed that the strain carried 15 of 42 (36%) recognized varicella vaccine-associated single-nucleotide polymorphisms, including all 5 of the fixed vaccine markers present in nearly all of the strains in the vaccine. The case of herpes zoster was relatively mild and resolved without complications.

  9. Posterior Ischemic Optic Neuropathy following Herpes Zoster Ophthalmicus

    Directory of Open Access Journals (Sweden)

    Mohammad Pakravan

    2009-01-01

    Full Text Available

    PURPOSE: To report a case of posterior ischemic optic neuropathy (PION following herpes zoster ophthalmicus (HZO. CASE REPORT: A 58-year-old woman with history of recent HZO in her right eye presented with acute painless loss of vision in the same eye to no light perception. Examination revealed a positive relative afferent pupillary defect and a normal appearing optic disc. Inflammatory and infiltrative lesions of the optic nerve were ruled out by laboratory and imaging studies. The patient received systemic acyclovir and prednisolone. Three months later, visual acuity improved to counting fingers, but the optic disc became pale and atrophic leading to a presumptive diagnosis of PION. Considering the positive PCR test for varicella zoster virus and the short time interval between the two presentations, HZO was considered as the most probable cause of the optic neuropathy. CONCLUSION: Herpes zoster ophthalmicus can be associated with PION.

  10. Herpes zoster on segmental vitiligo: Wolf’s isotopic response?

    Directory of Open Access Journals (Sweden)

    Mankesh Lal Gambhir

    2014-04-01

    Full Text Available “Wolf’s isotopic response” describes the occurrence of a new skin disorder at the site of another, unrelated and already healed skin disease. In most cases of isotopic response, the initial dermatosis is herpes zoster, herpes simplex, varicella, thrombophlebitis, scrofuloderma and striae distense. The most frequent second dermatoses are granulomatous reactions, particularly granuloma annulare, and lichenoid diseases. Various etiological reasons including viral, immunologic, neural and vascular have been put forth. We report here a case in which the second disease was herpes zoster that appeared over the same dermatomes of pre-existing segmental vitiligo. The occurrence of vitiligo as first and herpes zoster as second disease in the “Wolf’s isotopic response” has not, to the best of our knowledge, been reported previously.

  11. Shingles (Herpes Zoster) Vaccine (Zostavax(®)): A Review in the Prevention of Herpes Zoster and Postherpetic Neuralgia.

    Science.gov (United States)

    Keating, Gillian M

    2016-06-01

    Zostavax(®) is a live attenuated shingles (herpes zoster) vaccine approved in the EU for the prevention of herpes zoster (HZ) and postherpetic neuralgia (PHN) in adults aged ≥50 years. Zoster vaccine protected against HZ in adults aged 50-59 years (ZEST trial) and ≥60 years [Shingles Prevention Study (SPS)], and also reduced the burden of illness associated with HZ and the risk of PHN in adults aged ≥60 years (SPS). A large amount of real-world data also supports the efficacy of zoster vaccine. Results of the SPS Short- and Long-Term Persistence Substudies and real-world studies indicate that zoster vaccine provided continued benefit in the longer term, albeit with a gradual decline in vaccine efficacy over time; long-term effectiveness studies are ongoing. The need for a booster dose is still unknown, but a study showed that, if necessary, a booster dose administered to adults aged ≥70 years who received their first dose of zoster vaccine ≥10 years previously was immunogenic. Zoster vaccine had a favourable safety and tolerability profile, with the most commonly reported adverse events being non-severe injection-site reactions. In conclusion, zoster vaccine reduces the incidence of HZ and PHN, thereby reducing the burden of illness associated with HZ; improved uptake of zoster vaccine is needed.

  12. Herpes Zoster infection and radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Hayakawa, K.; Okazaki, A.; Mitsuhashi, N.; Ito, I.; Niibe, H. (Gunma Univ., Maebashi (Japan). School of Medicine)

    1981-02-01

    Between 1970 and 1979, among 3,320 patients with malignant neoplasms, herpes zoster (HZ) occurred in 54 (1.6%) after radiation therapy. The incidence of HZ infection was increased in patients with epipharyngeal cancer (10.0%), malignant lymphoma (5.7%), ovarial tumor (3.7%) and testicular tumor (3.6%). Most of these patients received extensive radiation therapy along the spinal cord and/or nerve roots. The location of HZ infection was divided as follows; HZ infectious lesion located in the area of (I-A) innervated segment of the irradiated nerve root (75.9%), (I-B) irradiated dermatome (5.6%) and (II) not associated with radiation field (18.5%). In 44 patients of I-A and B, HZ infection developed within a year, particularly in three months (22 cases) after the completion of irradiation. This latent period between completing irradiation and the development of HZ infection was likely to be compatible with the period between radiation therapy and earlier radiation injury. Among 10 patients in Group II, 7 patients developed HZ infection more than a year after radiation therapy. The cumulative survival of these patients except for the patients with malignant lymphoma was 66.7% and so HZ infection was considered to have no prognostic significance.

  13. Herpes Zoster-Induced Ogilvie’s Syndrome

    Directory of Open Access Journals (Sweden)

    Irfan Masood

    2015-01-01

    Full Text Available Ogilvie’s syndrome due to herpes zoster infection is a rare manifestation of VZV reactivation. The onset of rash of herpes zoster and the symptoms of intestinal obstruction can occur at different time intervals posing a significant diagnostic challenge resulting in avoidable surgical interventions. Herein, we describe a case of 35-year-old male who presented with 6-day history of constipation and colicky abdominal pain along with an exquisitely tender and vesicular skin eruption involving the T8–T11 dermatome. Abdominal X-ray and ultrasound revealed generalized gaseous distention of the large intestine with air up to the rectum consistent with paralytic ileus. Colonoscopy did not show any obstructing lesion. A diagnosis of Ogilvie’s syndrome associated with herpes zoster was made. He was conservatively managed with nasogastric decompression, IV fluids, and acyclovir. The patient had an uneventful recovery and was later discharged.

  14. Herpes Zoster Duplex Unilateralis: Two Cases and Brief Literature Review

    Science.gov (United States)

    Son, Jee Hee; Chung, Bo Young; Kim, Hye One; Cho, Hee Jin

    2016-01-01

    Cases involving dermatomal herpes zoster in two or more locations are rare, especially in immunocompetent patients. When two noncontiguous dermatomes are involved, if affected unilaterally, it is called herpes zoster duplex unilateralis; if bilaterally, bilateralis. Here, we report two cases of herpes zoster duplex unilateralis. A 66-year-old man presented with painful erythematous grouped vesicles on his left scalp, forehead, trunk, and back (left [Lt.] V1, Lt. T8). Histologic findings were consistent with herpetic infection. A 33-year-old woman presented with painful erythematous grouped vesicles and crust on her left forehead and neck (Lt. V1, Lt. C5). Both patients were treated with oral administration of famcyclovir 750 mg/day for seven days. PMID:27904277

  15. Recurrent herpes zoster in a child with SLE

    Directory of Open Access Journals (Sweden)

    Jain C

    1995-01-01

    Full Text Available A 12-year-old girl had systemic lupus erythematosus (SLE and type IV lupus nephritis since three-and-a-half years. She was treated with prednisolone and cyclophosphamide. She had first attack of herpes zoster (HZ involving eighth and ninth thoracic segments on right side at the age of nine years. Second attack occurred on the same segments on same side at the age of twelve years. The second attack of herpes zoster was treated with oral acyclovir 400 mg five times a day for seven days plus analgesics and multi-vitamins. Most probably this is the first case of recurrent herpes zoster (RHZ in a child in Indian literature.

  16. Isolated, complete paralytic mydriasis secondary to herpes zoster ophthalmicus.

    Science.gov (United States)

    Czyz, Craig N; Bacon, Thomas S; Petrie, Thomas P; Justice, Joshua D; Cahill, Kenneth V

    2013-06-01

    Herpes zoster ophthalmicus is a manifestation of herpes zoster when the ophthalmic division of the trigeminal nerve becomes involved. Ocular symptoms are varied and mainly due to inflammatory mechanisms. Total, external and/or internal ophthalmoplegias, as well as isolated third, fourth and sixth cranial nerve palsies have all been reported as complications. In a minority of cases, concurrent pupillary paralysis has been documented. The presentation of complete paralytic mydriasis as the sole cranial nerve complication following herpes zoster ophthalmicus infection is a rare finding. The postulated pathophysiologic aetiology is a partial third nerve palsy with the pupillary fibres for light and accommodation-convergence affected and motor fibres spared. The mechanism responsible for the postulated lesion is speculative.

  17. Herpes zoster at two different sites in the same individual

    Directory of Open Access Journals (Sweden)

    Kolalapudi Seetharam

    1995-01-01

    Full Text Available Herpes zoster occuring at two different sites in the same individual at the same time, involving more than two segments at each site has rarely been reported. We recently observed two such cases. The first patient was HIV-infected 10 year old haemophiliac who had zoster involving the distribution of the right C4, 5, 6 and left L 2, 3, 4 dermatomes and the second one was a 50 year old renal transplant recipient on immunosuppressive drugs who developed zoster at left C3, 4, 5 and left T 7, 8, 9.

  18. Purpuric herpes zoster in patients in therapy with clopidogrel.

    Science.gov (United States)

    Veraldi, S; Vaira, F; Nazzaro, G

    2015-08-01

    Clopidogrel is an adenosine diphosphate receptor antagonist used for the prevention of vascular events in patients with atherothrombotic diseases manifested by recent myocardial infarction, ischemic stroke or peripheral arterial disease. Diarrhoea, rash and pruritus are rather common side effects of clopidogrel. Other side effects include epistaxis, nausea, abdominal pain, vomiting, gastritis, gastric and duodenal ulcer. Thrombocytopenia is the most common laboratory abnormality. Leucopenia and neutropenia are rare. We report three cases of purpuric herpes zoster in patients in therapy with clopidogrel. To our knowledge, only one case of haemorrhagic herpes zoster has been published in a patient in therapy with this drug.

  19. Varicella-Zoster Virus Vasculopathy: The Growing Association Between Herpes Zoster and Strokes.

    Science.gov (United States)

    Powell, David R; Patel, Shiddhi; Franco-Paredes, Carlos

    2015-09-01

    Varicella-zoster virus (VZV) is herpes virus that after its reactivation from nerve ganglia to cause herpes zoster may lead to a variety of neurologic complications, including encephalitis, meningitis, retinal necrosis or myelitis. In addition, VZV can spread to arteries in the central nervous system and cause hemorrhagic or ischemic complications due to an inflammatory vasculopathy. In fact, there is a growing epidemiological and clinical recognition that there is an association between VZV reactivation and subsequent strokes. Herein, we present a case of an immune compromised individual with reactivation of VZV causing dermatomal herpes zoster followed by multifocal vasculopathy. We also review the literature to highlight key aspects of VZV-associated vasculopathy.

  20. Herpes zoster correlates with increased risk of Parkinson's disease in older people

    Science.gov (United States)

    Lai, Shih-Wei; Lin, Chih-Hsueh; Lin, Hsien-Feng; Lin, Cheng-Li; Lin, Cheng-Chieh; Liao, Kuan-Fu

    2017-01-01

    Abstract Little is known on the relationship between herpes zoster and Parkinson's disease in older people. This study aimed to explore whether herpes zoster could be associated with Parkinson's disease in older people in Taiwan. We conducted a retrospective cohort study using the claim data of the Taiwan National Health Insurance Program. There were 10,296 subjects aged 65 years and older with newly diagnosed herpes zoster as the herpes zoster group and 39,405 randomly selected subjects aged 65 years and older without a diagnosis of herpes zoster as the nonherpes zoster group from 1998 to 2010. Both groups were followed up until subjects received a diagnosis of Parkinson's disease. This follow-up design would explore whether subjects with herpes zoster were at an increased risk of Parkinson's disease. Relative risks were estimated by adjusted hazard ratio (HR) and 95% confidence interval (CI) using the multivariable Cox proportional hazards regression model. The incidence of Parkinson's disease was higher in the herpes zoster group than that in the nonherpes zoster group (4.86 vs 4.00 per 1000 person-years, 95% CI 1.14, 1.29). After adjustment for confounding factors, the multivariable Cox proportional hazards regression model revealed that the adjusted HR of Parkinson's disease was 1.17 for the herpes zoster group (95% CI 1.10, 1.25), compared with the nonherpes zoster group. Older people with herpes zoster confer a slightly increased hazard of developing Parkinson's disease when compared to those without herpes zoster. We think that herpes zoster correlates with increased risk of Parkinson's disease in older people. When older people with herpes zoster seek help, clinicians should pay more attention to the development of the cardinal symptoms of Parkinson's disease. PMID:28207515

  1. The dynamics of neopterin level in patients with herpes zoster

    Directory of Open Access Journals (Sweden)

    A. L. Yakubenko

    2015-01-01

    Full Text Available Neopterin is a specific marker of cellular immunity and monocytes/macrophages activation. Correlation between serum neopterin levels and clinical features of herpes zoster is unknown.The objective of the study was to determine the concentration of serum neopterin in patients with herpes zoster.Methods: 55 patients with herpes zoster (30 HIV-positive and 25 HIV-negative were included. Serum neopterin levels were measured three times during the observation period (before onset of treatment with acyclovir, on the 3rd day of treatment and after healing of skin lesions. The clinical course and dynamics of laboratory data were also evaluated.Results: The study showed that elevated serum neopterin levels were found in all patients with herpes zoster. Neopterin concentrations were significantly reduced during acyclovir treatment (from 30 (17; 32 to 12 (11; 27 nmol/L (p = 0,0000001, but remained above the upper limit of normal by the time skin lesions were healed in most patients. Neopterin levels before and after treatment weren’t associated with HIV-status. Neopterin concentration was slightly higher in patients with HIV infection on the third day of observation only, that could reflect the abnormal immunoreactivity of this host. Neopterin levels in patients with varicella zoster viremia were higher compared to patients without viremia on the third day of treatment with acyclovir (23.5 (12,7; 30,0 and 12 (4,2, 24,5 nmol/L, respectively, p = 0,037.Conclusions: These results suggest that the dynamics of serum neopterin could be a marker of effectiveness of immune response in herpes zoster.

  2. Increasing trends of herpes zoster in Australia.

    Directory of Open Access Journals (Sweden)

    Raina MacIntyre

    Full Text Available Increasing trends in incidence of herpes zoster (HZ have been reported in Australia and internationally. This may reflect the impact of childhood VZV vaccination programs introduced universally in Australia in late 2005. The objective of this study was to evaluate changes in incidence of HZ and PHN in Australia over time, and associated healthcare resource utilisation.Australian data on general practice (GP encounters for HZ, specific antiviral prescribing data from the pharmaceutical benefits scheme, emergency department presentations from the states of NSW and Victoria and national hospitalisation data for HZ were analysed for time trends using regression models. Two time periods (2000-2006 and 2006-2013 were compared which correspond broadly with the pre- and post- universal VZV vaccination period.All data sources showed increasing rates of HZ with age and over time. The GP database showed a significant annual increase in encounters for HZ of 2.5 per 100,000 between 1998 and 2013, and the rates of prescriptions for HZ increased by 4.2% per year between 2002 and 2012. In the 60+ population HZ incidence was estimated to increase from 11.9 to 15.4 per 1,000 persons using GP data or from 12.8 to 14.2 per 1,000 persons using prescription data (p<0.05, between the two periods. Hospitalisation data did not show the same increasing trend over time, except for the age group ≥80 years. Most emergency visits for HZ were not admitted, and showed significant increases over time.The burden of HZ in Australia is substantial, and continues to increase over time. This increase is seen both pre- and post-universal VZV vaccination in 2005, and is most prominent in the older population. The substantial burden of HZ, along with ageing of the Australian population and the importance of healthy ageing, warrants consideration of HZ vaccination for the elderly.

  3. Breakthrough VZV infection after immunization, presenting as herpes zoster.

    NARCIS (Netherlands)

    Schade, R.P.; Bakkers, J.; Cornelissen, M.; Koster-Kamphuis, L.; Melchers, W.J.G.; Galama, J.M.D.

    2008-01-01

    An immunocompromized, VZV-vaccinated child had a breakthrough infection with VZV, acquired at a day-care centre during a chickenpox outbreak. Interestingly, the infection manifested as herpes zoster of 1 dermatome. Typing showed wild-type virus, which suggests that exogenous reinfection with a new s

  4. Increased risk of cardiovascular events in patients with herpes zoster: a population-based study.

    Science.gov (United States)

    Wu, Po-yuan; Lin, Cheng-Li; Sung, Fung-Chang; Chou, Tzu-Chieh; Lee, Yuan-Teh

    2014-05-01

    The association between herpes zoster and cardiovascular complications remains vague with limited study on the association between these two disorders. This study evaluated the risk of cardiovascular diseases in patients with herpes zoster. From insurance claims data of Taiwan, 19,483 patients with herpes zoster diagnosed in 1998-2008 and 77,932 subjects without herpes zoster were identified in this study. Both cohorts were followed up until the end of 2010 to measure the incidence of arrhythmia and coronary artery disease. The incidence rate ratio and adjusted hazard ratio (HR) of the cardiovascular complications with 95% confidence interval (CI) were estimated. The incidence of arrhythmia was 1.17-fold greater in the herpes zoster cohort than in the non-herpes zoster cohort (13.2 vs. 11.3 per 1,000 person-years), with an adjusted HR of 1.16 (P herpes zoster cohort was 1.16-fold higher than that in the non-herpes zoster cohort (9.02 vs. 7.83 per 1,000 person-years), with an adjusted HR of 1.11 (P herpes zoster diagnosis. The risk measured for these disorders declined over time. Comorbidities of hypertension, diabetes, and hyperlipidemia also contributed to these cardiovascular disorders with greater extent. It is concluded that the contribution of herpes zoster to the risk of arrhythmia and cardiovascular diseases is less strong than that of hypertension, diabetes, and hyperlipidemia.

  5. Penile herpes zoster: an unusual location for a common disease

    Directory of Open Access Journals (Sweden)

    Milan Bjekic

    2011-12-01

    Full Text Available Herpes zoster is a common dermatological condition which affects up to 20% of the population, most frequently involving the thoracic and facial dermatomes with sacral lesions occurring rarely and only a few reported cases of penile shingles. Case report: We report two cases of unusual penile clinical presentations of varicella zoster virus infection in immunocompetent men. The patients presented with grouped clusters of vesicles and erythema on the left side of penile shaft and posterior aspect of the left thigh and buttock, involving s2-s4 dermatomes. The lesions resolved quickly upon administration of oral antiviral therapy. Conclusion: Penile herpes zoster should not be overlooked in patients with unilateral vesicular rash.

  6. Incidence of herpes zoster infections in juvenile idiopathic arthritis patients.

    Science.gov (United States)

    Nimmrich, S; Horneff, G

    2015-03-01

    The risk of herpes zoster among patients with juvenile idiopathic arthritis (JIA) exposed to biologics has not been evaluated. We determined incidence rates of herpes zoster among children with JIA in correlation with medication at time of occurrence and total drug exposure. The German biologics register database was used to identify patients with herpes zoster. Crude infection rates and incidence ratios (IRR) were compared to published rates. Demographics and overall exposure and particular exposure time to corticosteroids, immunosuppressive drugs and biologics were analyzed. The JIA cohort included 3,042 patients with 5,557.9 person-years of follow-up; 1,628 have used corticosteroids, 2,930 methotrexate and 1,685 etanercept. In total, 17 herpes zoster events have been documented [6/1,000 patients (3.5-9.0); 3.1/1,000 patient-years (1.9-4.9)]. Thus, the incidence rate in JIA patients was higher than expected [IRR 2.9 (1.8-4.5), p herpes zoster. Compared to the healthy population, a significant higher IRR is observed in JIA patients who received a monotherapy with etanercept or in combination with steroids and methotrexate, but not in JIA patients exposed to methotrexate without biologics. In comparison with our control group of patients treated with methotrexate, the IRR was higher for exposure to etanercept monotherapy and combination of etanercept and corticosteroids irrespective of methotrexate use. A generally higher incidence rate in JIA patients treated with etanercept was observed. No serious or refractory manifestations occurred.

  7. Management and Prevention of Herpes Zoster Ocular Disease.

    Science.gov (United States)

    Cohen, Elisabeth J

    2015-10-01

    Herpes zoster (HZ) is caused by reactivation of latent varicella zoster virus (VZV) in people who have had chicken pox, usually resulting in a painful, unilateral, dermatomal, vesicular rash. Herpes zoster ophthalmicus occurs when the first division of cranial nerve V is involved. HZ is common, with approximately 1 million new cases per year in the United States, and occurs in 1 in 3 persons. Although the rate of HZ increases with age, over half of all cases occur under the age of 60 years. Complications of herpes zoster ophthalmicus include eye disease, postherpetic neuralgia (PHN), and strokes. VZV has also been found in temporal arteritis biopsies. There is growing evidence that HZ is followed by chronic active VZV infection contributing to these complications. In view of this, and the efficacy of suppressive antiviral treatment in reducing recurrent herpes simplex keratitis, a randomized controlled trial of suppressive valacyclovir to reduce new or worsening anterior segment disease and/or PHN is needed. The zoster vaccine (ZV) is safe and effective in reducing the burden of illness, severity of PHN, and incidence of HZ. It is Centers for Disease Control and Prevention recommended for persons aged 60 years and above without impaired cellular immunity, and Food and Drug Administration approved for those aged 50 and older. It is most effective in preventing HZ in recipients in their 50s. Because of underusage of the ZV, it has not impacted the epidemiology of the disease. Barriers to its use include cost, variable reimbursement, frozen storage, and lack of a strong recommendation by doctors.

  8. Bullous Variant of Sweet’s Syndrome after Herpes Zoster Virus Infection

    OpenAIRE

    2011-01-01

    Aim: Cutaneous manifestations of Sweet’s syndrome (SS) are typically painful plaque-forming erythematous papules, while bullae are quite uncommon. We present a case of bullous variant of SS in acute myeloid leukaemia. In this case, herpes infection of the left mandible had preceded the development of SS. Case Report: A 75-year-old male with myelodysplastic syndrome first presented with herpes zoster virus infection-like bullae and erosive plaques on the left side of the face and neck. Treatme...

  9. Incidence of Herpes Zoster in relationship with Climate Factors from 2009 to 2011

    Directory of Open Access Journals (Sweden)

    Herning Adinda

    2015-09-01

    Full Text Available Background: Herpes zoster, or shingles, is a skin or mucous infection caused by the reactivation of varicella-zoster virus (VZV. Seasonal pattern of herpes zoster incidence was reported in some countries, indicating that emergence of this disease was caused by the reactivation of latent Varicella-Zoster Virus (VZV rather than new exposures to VZV. On the other hand, the VZV primary infection difference between tropical and temperate zones may have implications for virus reactivation as herpes zoster. The aim of this study was to identify the incidence of herpes zoster in Dr. Hasan Sadikin General Hospital Bandung, West Java related to the change of rainfall, air temperature and humidity from 2009 to 2011. Methods: A descriptive retrospective study was carried out to 341 medical records of herpes zoster patients from Dr. Hasan Sadikin General Hospital Bandung periode 2009 to 2011. Data on climate factors, i.e. rainfall, air temperature, and relative humidity, were obtained from the Indonesian Meteorology, Climatology, and Geophysical Agency. The collected data were presented using tables and figures. Result: The highest number of herpes zoster cases occured during the period when the highest annually total rainfall and annually mean relative humidity occurred. Conclusions: The finding of this study shows that herpes zoster cases have the same pattern with the rainfall and relative humidity. These findings can inform better prevention of herpes zoster. However, further research is needed to get more comprehensive understanding on this relationship.

  10. Varicella Zoster Virus in Saliva of Patients With Herpes Zoster

    Science.gov (United States)

    Mehta, Satish K.; Tyring, Stephen K.; Gilden, Donald H.; Cohrs, Randall J.; Leal, Melanie J.; Castro, Victoria A.; Feiveson, Alan H.; Ott, C. Mark; Pierson, Duane L.

    2007-01-01

    Background. VZV DNA is present in saliva of healthy astronauts and patients with Ramsay Hunt syndrome (geniculate zoster). We hypothesized that a prospective analysis of patients with zoster would detect VZV in saliva independent of zoster location. Methods. We treated 54 patients with valacyclovir. On the first treatment day, 7- and 14-days later, pain was scored and saliva examined for VZV DNA. Saliva from six subjects with chronic pain and 14 healthy subjects was similarly studied. Results. Follow-up data was available for 50/54 patients. Pain decreased in 43/50 (86 percent), disappeared in 37 (74 percent), recurred after disappearing in three (6 percent) and increased in four (8 percent). VZV DNA was found in every patient the day treatment was started, decreased in 47/50 (94 percent), transiently increased in three (6 percent) before decreasing, increased in two (4 percent) and disappeared in 41 (82 percent). There was a positive correlation between the presence of VZV DNA and pain, as well as between the VZV DNA copy number and pain (Pzoster patients.

  11. Herpes zoster in multiple myeloma patients during bortezomib treatment

    Directory of Open Access Journals (Sweden)

    I. N. Nazarova

    2011-01-01

    Full Text Available Recent advances in multiple myeloma (MM treatment associated with new drug use including bortezomib. Experiences in wide ambul atory drug use confirm therapy success for this serious disease, but at the same time reveals the most common side effects. One of th e most significant is the reactivation of Herpes zoster , which leads to decrease MM therapy results because of inability to perform standard therapy in these patients. Literature data and own experiences about reactivation of Herpes zoster during bortezomib therapy as monothe rapy and in combination, which varies from 7 to 34% according to different authors and 25% of own experiences, is presented. Treatment and preventive schedule of this complication are shown.

  12. Increased risk of herpes zoster in children with cancer: A nationwide population-based cohort study.

    Science.gov (United States)

    Lin, Hsiao-Chuan; Chao, Yu-Hua; Wu, Kang-Hsi; Yen, Ting-Yu; Hsu, Yu-Lung; Hsieh, Tsung-Hsueh; Wei, Hsiu-Mei; Wu, Jhong-Lin; Muo, Chih-Hsin; Hwang, Kao-Pin; Peng, Ching-Tien; Lin, Cheng-Chieh; Li, Tsai-Chung

    2016-07-01

    Herpes zoster is rare in healthy children, but immunocompromised persons have an increased risk of herpes zoster and severe diseases. Considering the very limited information on herpes zoster in children with cancer, we performed a nationwide population-based cohort study to estimate the incidence of herpes zoster in children with cancer and to explore the association between the 2 diseases.Data were obtained from the National Health Research Institutes Database in Taiwan. A total of 4432 children with newly diagnosed cancer between 2000 and 2007 were identified as the cancer cohort, and 17,653 children without cancer frequency-matched by sex and age at entry were considered the noncancer cohort. The association between herpes zoster and childhood cancer was determined.Children with cancer had a higher risk of herpes zoster. The incidence rate of herpes zoster was higher in the cancer cohort than in the noncancer cohort (20.7 vs 2.4 per 10,000 person-years; IRR = 8.6; 95% CI = 4.8-15.6). The cumulative incidence was significantly higher in the cancer cohort (P herpes zoster. In addition to early antiviral treatment, vaccination with heat-treated zoster vaccine or adjuvanted subunit vaccine could be an appropriate policy to decrease the incidence in children with cancer.

  13. Post herpes-zoster scar sarcoidosis with pulmonary involvement

    Directory of Open Access Journals (Sweden)

    Archana Singal

    2014-01-01

    Full Text Available Cutaneous sarcoidosis presents with a wide range of clinical presentations. An uncommon cutaneous manifestation is infiltration of old cutaneous scars with non-caseating granulomas known as scar sarcoidosis. Most of the patients with this clinical entity have other systemic manifestations, particularly pulmonary changes. We report a case of a 50 years old man, presenting with cutaneous sarcoidosis overlying scars of healed herpes zoster.

  14. Herpes zoster infection, vaccination and immunocompromised rheumatology patients.

    LENUS (Irish Health Repository)

    O'Connor, Mortimer B

    2013-01-01

    Varicella is a self-limiting and relatively mild disease of childhood, although it is frequently more severe and complicated among the immunocompromised rheumatology patients on immunomodulator therapies. In addition, future reactivation of the dormant virus in dorsal root ganglia may cause herpes zoster infection, which can be very debilitating. In this manuscript, we discuss the nature of this infection along with its potential vaccine especially among rheumatology patients.

  15. Longitudinal analysis of varicella-zoster virus DNA on the ocular surface associated with herpes zoster ophthalmicus

    NARCIS (Netherlands)

    Zaal, M.J.; Volker-Dieben, H.J.; Wienesen, M.; D'Amaro, J.; Kijlstra, A.

    2001-01-01

    PURPOSE: Longitudinal analysis of varicella-zoster virus DNA on the ocular surface of patients with herpes zoster ophthalmicus. METHODS: Clinical specimens were obtained from the bulbar conjunctival surface with a cotton-tipped swab at weekly intervals for 6 consecutive weeks from 21 patients with a

  16. Herpes Zoster Infections in SLE in a University Hospital in Saudi Arabia: Risk Factors and Outcomes

    Directory of Open Access Journals (Sweden)

    Afsar Sayeeda

    2010-01-01

    (0/23. None of the patients had postherpetic neuralgia or bacterial super infection. Immunosuppressive medications were discontinued at the time of diagnosis of Zoster in 19 of 32 patients and all patients received antiviral medications.There were no permanent neurologic deficits or deaths. We conclude that Herpes Zoster infections occur at increased frequency among patients with SLE and carry significant morbidity. Immunosuppressive therapy and severe manifestations of lupus may be risk factors for the development of Herpes Zoster although not necessarily at the time of disease flare or immunosuppressive therapy. Our study suggests that although Herpes Zoster occurs frequently in patients with SLE, it has a relatively benign course.

  17. DUAL EPISODES OF HERPES ZOSTER IN A SINGLE YEAR IN IMMUNOCOMPETENT MALE CASE REPORT

    Directory of Open Access Journals (Sweden)

    Gaurav

    2014-12-01

    Full Text Available Herpes zoster, is a viral disease characterised by painful skin rash with blister in a limited area on one side of body. Varicella zoster virus1 is the cause of both varicella (Chicken pox and zoster (Shingles.It initially causes chicken pox and then remains latent for decades in cranial nerve, dorsal root and autonomic nervous system ganglia. 2 Three genotypes of this alpha – herpesvirus have been identified and shown to have geographical variations. 3 The virus gets reactivated after a variable period of time to cause zoster. Recurrences of zoster4 are common in immune-compromised patients, those having lymphoma, hiv, diabeties or on immune-supressive drugs especially the more profound suppression required for bone marrow transplantation. 5,6 However recurrences are rare in immune-competent individuals. We report here a case of recurrent herpes zoster in a immune-competent male within 1 year of the first attack of herpes zoster

  18. Herpes zoster vaccine effectiveness and manifestations of herpes zoster and associated pain by vaccination status.

    Science.gov (United States)

    Marin, Mona; Yawn, Barbara P; Hales, Craig M; Wollan, Peter C; Bialek, Stephanie R; Zhang, John; Kurland, Marge J; Harpaz, Rafael

    2015-01-01

    Options for managing herpes zoster (HZ)-related pain and complications have limited effectiveness, making HZ prevention through vaccination an important strategy. Limited data are available on HZ vaccine effectiveness against confirmed HZ and manifestations of HZ among vaccinated persons. We conducted a matched case-control study to assess HZ vaccine effectiveness for prevention of HZ and other HZ-related outcomes and a cohort study of persons with HZ to compare HZ-related outcomes by vaccination status. Cases were identified through active surveillance among persons age ≥ 60 years with HZ onset and health-care encounters during 2010-2011 in Southeastern Minnesota. Controls were age- and sex-matched to cases. Data were collected by medical record review and from participants via interviews and daily pain diaries. 266 HZ case-patients and 362 matched controls were enrolled in the vaccine effectiveness studies and 303 case-patients in the cohort study of HZ characteristics by vaccination status. Vaccination was associated with 54% (95% CI:32%-69%) reduction in HZ incidence, 58% (95% CI:31%-75%) reduction in HZ prodromal symptoms, and 70% (95% CI:33%-87%) reduction in medically-attended prodrome. HZ vaccine was statistically significant effective at preventing postherpetic neuralgia (PHN) measured at 30 d after rash onset, 61% (95% CI: 22%-80%). Among persons who developed HZ, no differences were found by vaccination status in severity or duration of HZ pain after rash onset. In this population-based study, HZ vaccination was associated with >50% reduction in HZ, HZ prodrome, and medically-attended prodrome.

  19. Herpes zoster reactivation after extracorporeal shock wave lithotripsy: A case report

    Directory of Open Access Journals (Sweden)

    Krishnamoorthy Hariharan

    2016-01-01

    Full Text Available Herpes zoster is a reactivated varicella-zoster virus (VZV infection of the sensory nerve ganglion, peripheral nerve, and its branches. Mechanical trauma to the nervous system can reactivate VZV. It is well known that extracorporeal shock wave lithotripsy (SWL can produce mechanical damage to the tissue. We report a rare case of herpes zoster reactivation after SWL for treatment of 1.2 cm size renal stone in a 63-year-old male patient.

  20. A rare case of Herpes zoster oticus in an immunocompetent patient

    Directory of Open Access Journals (Sweden)

    Ganesh Prabhakar Dhavalshankh

    2012-10-01

    Full Text Available Herpes zoster oticus in healthy persons is uncommon, though it has been described in immunocompromised patients. We describe a case of disseminated herpes zoster oticus in an elderly man with no apparent immunosuppressive condition. The patient was treated successfully with oral Acyclovir. We suggest that disseminated zoster can occur in an immunocompetent host and should be promptly recognized and treated to prevent serious complications.

  1. Abdominal distention and constipation followed by herpes zoster infection in a 2-month-old female infant.

    Science.gov (United States)

    Wang, Hongfeng; Fang, Fang

    2015-08-01

    Gastrointestinal symptoms of herpes zoster in infants are rarely reported. A 2-month-old female infant presented with herpes zoster and additional complication of abdominal distention and constipation. While rashes resolved, abdominal distention and constipation improved soon. To our knowledge, this is the first report of gastrointestinal complication of herpes zoster in infants. Physicians should be aware of the potential for motor involvement of herpes zoster in such infants. Herpes zoster should be considered during the diagnosis in the event of infants presenting with constipation.

  2. Possible enhancement of BP180 autoantibody production by herpes zoster.

    Science.gov (United States)

    Kamiya, Koji; Aoyama, Yumi; Suzuki, Takahiro; Niwa, Haruo; Horio, Ai; Nishio, Eiichi; Tokura, Yoshiki

    2016-02-01

    Bullous pemphigoid (BP) is an autoimmune blistering disease caused by autoantibodies against type XVII collagen/BP180 (BP180). Although the mechanisms of autoantibody production remain to be elucidated, herpes virus infections have been identified as a possible triggering factor for pemphigus. We report a case of herpes zoster (HZ) having anti-BP180 serum antibodies. The patient developed sudden-onset, tense blisters and edematous erythema on the right anterior chest, shoulder and upper back. Histopathology showed remarkable degeneration of keratinocytes, acantholysis and blister formation with ballooning cells, indicating herpes virus infection. A polymerase chain reaction analysis of varicella zoster virus (VZV) was positive in crusts and effusions from the skin lesions, confirming the definitive diagnosis of HZ. Notably, we found that the patient had anti-BP180 serum antibodies in association with the occurrence of HZ. After successful treatment with valacyclovir hydrochloride for 7 days, the serum levels of anti-BP180 antibodies decreased in accordance with the improvement of skin lesions. These findings suggest that the production of anti-BP180 antibodies could be triggered by the reactivation of VZV.

  3. Herpes Zoster in a 3-month-old infant

    Directory of Open Access Journals (Sweden)

    Duarte Malveiro

    2015-12-01

    Full Text Available Introduction: Herpes Zoster (HZ is rare in infancy and results from reactivation of varicella-zoster virus, latent in the dorsal root ganglia of sensory or cranial nerves after primary infection (chickenpox. Case Report: We describe the case of an healthy infant, three months old, without previous clinical symptoms of chickenpox, in spite of having contacted with the disease at two weeks of life. She was hospitalized for vesicular-papular rash involving unilaterally dermatomes L4 and L5 and was treated with acyclovir with good clinical outcome. Conclusion: The immaturity of the immune system and the interference of maternal antibodies contribute to the manifestation of HZ in the first year of life. In a previously healthy child it is not recommended the exclusion of underlying immunodeficiency or malignant disease.

  4. Herpes zoster correlates with increased risk of Parkinson's disease in older people: A population-based cohort study in Taiwan.

    Science.gov (United States)

    Lai, Shih-Wei; Lin, Chih-Hsueh; Lin, Hsien-Feng; Lin, Cheng-Li; Lin, Cheng-Chieh; Liao, Kuan-Fu

    2017-02-01

    Little is known on the relationship between herpes zoster and Parkinson's disease in older people. This study aimed to explore whether herpes zoster could be associated with Parkinson's disease in older people in Taiwan.We conducted a retrospective cohort study using the claim data of the Taiwan National Health Insurance Program. There were 10,296 subjects aged 65 years and older with newly diagnosed herpes zoster as the herpes zoster group and 39,405 randomly selected subjects aged 65 years and older without a diagnosis of herpes zoster as the nonherpes zoster group from 1998 to 2010. Both groups were followed up until subjects received a diagnosis of Parkinson's disease. This follow-up design would explore whether subjects with herpes zoster were at an increased risk of Parkinson's disease. Relative risks were estimated by adjusted hazard ratio (HR) and 95% confidence interval (CI) using the multivariable Cox proportional hazards regression model.The incidence of Parkinson's disease was higher in the herpes zoster group than that in the nonherpes zoster group (4.86 vs 4.00 per 1000 person-years, 95% CI 1.14, 1.29). After adjustment for confounding factors, the multivariable Cox proportional hazards regression model revealed that the adjusted HR of Parkinson's disease was 1.17 for the herpes zoster group (95% CI 1.10, 1.25), compared with the nonherpes zoster group.Older people with herpes zoster confer a slightly increased hazard of developing Parkinson's disease when compared to those without herpes zoster. We think that herpes zoster correlates with increased risk of Parkinson's disease in older people. When older people with herpes zoster seek help, clinicians should pay more attention to the development of the cardinal symptoms of Parkinson's disease.

  5. Herpes zoster: Epidemiología y clínica Clinical and epidemiological aspects of Herpes zoster

    OpenAIRE

    Claudia Vujacich; Emmanuel Poggi; Diego Cecchini; Pablo Luchetti; Daniel Stamboulian

    2008-01-01

    El herpes zoster (HZ) constituye una enfermedad de distribución mundial; sin embargo, existen es casos datos comunicados sobre la misma en países de Latinoamérica. Con el objetivo de evaluar aspectos clínicos y epidemiológicos de esta enfermedad en nuestra población, realizamos un análisis retrospectivo de historias clínicas de un centro privado de referencia en enfermedades infecciosas en Buenos Aires, Argentina (período: 2000-2005). Se realizó un análisis estadístico univariado para evaluar...

  6. Clinical and biological differences between recurrent herpes simplex virus and varicella-zoster virus infections

    Energy Technology Data Exchange (ETDEWEB)

    Straus, S.E. (National Institute of Allergy and Infectious Diseases, Bethesda, MD (USA))

    1989-12-01

    The major features that distinguish recurrent herpes simplex virus infections from zoster are illustrated in this article by two case histories. The clinical and epidemiologic features that characterize recurrent herpes simplex virus and varicella-zoster virus infections are reviewed. It is noted that herpesvirus infections are more common and severe in patients with cellular immune deficiency. Each virus evokes both humoral and cellular immune response in the course of primary infection. DNA hybridization studies with RNA probes labelled with sulfur-35 indicate that herpes simplex viruses persist within neurons, and that varicella-zoster virus is found in the satellite cells that encircle the neurons.

  7. Distrofia simpática reflexa pós herpes zoster Reflex sympathetic dystrophy following herpes zoster

    Directory of Open Access Journals (Sweden)

    Catia Susana Harumi Minami

    2004-08-01

    Full Text Available A distrofia simpática reflexa (DSR é uma síndrome dolorosa pouco entendida que consiste na presença de múltiplos sinais e sintomas incluindo dor, edema, alterações cutâneas distróficas e disfunção autonômica envolvendo uma ou mais extremidades. Nem sempre a DSR pós-herpes zóster é facilmente reconhecida. Poucos relatos dessa complicação foram publicados, o que torna interessante esta descrição. Apresentamos o caso de uma mulher branca, de 65 anos de idade cujos sinais e sintomas característicos de DSR no membro superior direito surgiram após 4 semanas do aparecimento das lesões de herpes zóster envolvendo trajeto dermatomérico. Com o diagnóstico precoce e abordagem terapêutica com calcitonina nasal e fisioterapia houve melhoras funcional e álgica satisfatórias em um mês de tratamento.The reflex sympathetic dystrophy (RSD is a poorly understood, painful syndrome that consists of multiple clinical manifestations, including pain, swelling, dystrophic cutaneous changes and autonomic dysfunction involving one or more extremities. The RSD following herpes zoster is not always easily recognized, and only a few documented cases of this complication have been reported, what makes this report even more interesting. We present the case of a 65 years old white woman, with characteristic signs and symptoms of RSD in the right upper limb observed four weeks after she had had a typical herpes zoster involving the dermatomes. Early diagnosis and treatment with intranasal calcitonin and physiotherapy lead to progressive functional and pain improvements after one month.

  8. Predictive factors of herpes zoster HIV-infected patients: another adverse effect of crack cocaine.

    Science.gov (United States)

    Nacher, Mathieu; Basurko, Celia; Adenis, Antoine; Gaubert-Marechal, Emilie; Mosnier, Emilie; Edouard, Sophie; Vantilcke, Vincent; Sivapregassam, Sindou; Tressières, Benoit; Cabié, André; Couppié, Pierre

    2013-01-01

    A retrospective cohort study was conducted on 1541 HIV-infected patients to determine variables associated with the incidence of herpes zoster. A single failure Cox model showed that herpes zoster incidence increased following the first 6 months of antiretroviral treatment adjusted hazard ratio (AHR)=5 (95%CI=2.6-9.2), P60 years age group AHR=2 (95%CI=1-4), P=0.04; in patients in the top CD8 quartile AHR=2.1 (95%CI=1.3-3.6), PHerpes zoster incidence increased in patients with CD4 countsherpes zoster incidence. The present study is the first to suggest that crack cocaine is associated with an increased incidence of herpes zoster. The neurological or immunological effects of crack are discussed.

  9. Salivary Varicella Zoster Virus in Astronauts and in Patients of Herpes Zoster

    Science.gov (United States)

    Mehta, Satish; Pierson, Duane L.

    2010-01-01

    Spaceflight is a uniquely stressful environment with astronauts experiencing a variety of stressors including: isolation and confinement, psychosocial, noise, sleep deprivation, anxiety, variable gravitational forces, and increased radiation. These stressors are manifested through the HPA and SAM axes resulting in increased stress hormones. Diminished T-lymphocyte functions lead to reactivation of latent herpes viruses in astronauts during spaceflight. Herpes simplex virus reactivated with symptoms during spaceflight whereas Epstein-Barr virus (EBV), cytomegalovirus (CMV), and varicella zoster virus (VZV) reactivate and are shed without symptoms. EBV and VZV are shed in saliva and CMV in the urine. The levels of EBV shed in astronauts increased 10-fold during the flight; CMV and VZV are not typically shed in low stressed individuals, but both were shed in astronauts during spaceflight. All herpesviruses were detected by polymerase chain reaction (PCR) assay. Culturing revealed that VZV shed in saliva was infectious virus. The PCR technology was extended to test saliva of 54 shingles patients. All shingles patients shed VZV in their saliva, and the levels followed the course of the disease. Viremia was also found to be common during shingles. The technology may be used before zoster lesions appear allowing for prevention of disease. The technology may be used for rapid detection of VZV in doctors? offices. These studies demonstrated the value of applying technologies designed for astronauts to people on Earth.

  10. Cost-effectiveness of vaccination of the elderly against herpes zoster in The Netherlands

    NARCIS (Netherlands)

    de Boer, Pieter T; Pouwels, Koen B; Cox, Juul M; Hak, Eelko; Wilschut, Jan C; Postma, Maarten J

    2013-01-01

    BACKGROUND: Each year a substantial number of Dutch elderly suffers from herpes zoster (HZ), caused by the reactivation of the varicella zoster virus (VZV). A potential complication of HZ is postherpetic neuralgia (PHN) which results in a prolonged loss of quality of life. A large randomized clinica

  11. Occurrence of herpes zoster varicella infections after completion of treatment for Hodgkin's disease

    Energy Technology Data Exchange (ETDEWEB)

    Pauw, B.E. de; Janssen, J.Th.P.; Vaissier, P.; Haanen, C. (Katholieke Univ. Nijmegen (Netherlands). Dept. of Internal Medicine)

    1983-01-01

    Retrospective analysis of 210 cases of patients with Hodgkin's disease revealed an overall incidence of herpes zoster varicella of 9.5 per cent. Patients with the mixed cellular histological subtype showed a significantly increased (p < 0.05) risk as compared with the total population. More than 90 per cent of the herpes zoster varicella infections occurred after termination of treatment; a combination of radiotherapy with chemotherapy proved to be a predisposing factor.

  12. Herpes Zoster Lesions on Reconstructed Breast Skin: Rare Objective Proof of Reinervation.

    Science.gov (United States)

    Weitgasser, Laurenz; Valina, Stephan Wolfgang; Schoeller, Thomas; Ehebruster, Gudrun

    2017-01-01

    Blazed up Herpes zoster lesions have been described in very few patients after free and pedicled flap transfer for reconstructive purpose. Although sensory recovery after flap reconstructions has been studied extensively most studies addressed subjective perceptions of sensation. Objective investigations of spontaneous reinervation of free and pedicled flaps are rare. We would like to present a witnessed herpes zoster infection of a latissimus dorsi skin flap 2 years after breast reconstruction.

  13. Unusual oral complications of herpes zoster infection: report of a case and review of literature.

    Science.gov (United States)

    Jain, Manoj Kumar; Manjunath, K S; Jagadish, S N

    2010-11-01

    A case of herpes zoster infection with unusual oral complications involving the mandibular division of the trigeminal nerve is presented. The post-herpetic complications of osteonecrosis, spontaneous exfoliation of teeth, and subsequent pathologic fracture of mandible in the absence of concurrent predisposing factors in a 65-year-old man are demonstrated. Forty-one cases with osteonecrosis and spontaneous exfoliation of teeth previously presented in the literature are reviewed. This is the first report of pathologic fracture after herpes zoster infection.

  14. Herpes Zoster as a Predictor of HIV Infection in Taiwan: A Population-Based Study.

    Science.gov (United States)

    Lee, Yuan-Ti; Nfor, Oswald Ndi; Tantoh, Disline Manli; Huang, Jing-Yang; Ku, Wen-Yuan; Hsu, Shu-Yi; Ko, Pei-Chieh; Hung, Hung-Chang; Jan, Cheng-Feng; Liaw, Yung-Po

    2015-01-01

    This study aimed to investigate the association between herpes zoster (HZ) and human immunodeficiency virus (HIV). Data were retrieved from the Longitudinal Health Insurance Databases (LHID 2005 and 2010), Taiwan. The International Classification of Diseases, 9th Revision, Clinical Modification [ICD-9-CM] codes were used to identify Hz from 2001-2004. Identification of HIV infection was from 2005-2010. The hazard ratios of HIV among herpes zoster infected and non-herpes zoster infected patients were estimated using multiple Cox proportional hazard model. In general, 19685 participants were identified with Hz. The HIV incidence rates (per 104 person-months) in herpes zoster infected and non-infected patients were 0.191(95% CI 0.130-0.280) and 0.079 (95% CI 0.074-0.084), respectively while the hazard ratio (HR) of HIV among infected individuals was 3.518 (95% CI 2.375-5.211). This study concludes that herpes zoster could be considered as a predictor of HIV infection especially among Asian populations, hence it is vital to test herpes zoster infected individuals for HIV antibodies.

  15. The Short- and Long-Term Risk of Stroke after Herpes Zoster: A Meta-Analysis

    Science.gov (United States)

    Liu, Xuechun; Guan, Yeming; Hou, Liang; Huang, Haili; Liu, Hongjuan; Li, Chuanwen; Zhu, Yingying; Tao, Xingyong; Wang, Qingsong

    2016-01-01

    Background Accumulating evidence indicates that stroke risk may be increased following herpes zoster. The aim of this study is to perform a meta-analysis of current literature to systematically analyze and quantitatively estimate the short and long-term effects of herpes zoster on the risk of stroke. Methods Embase, PubMed and Cochrane library databases were searched for relevant studies up to March 2016. Studies were selected for analysis based on certain inclusion and exclusion criteria. Relative risks with 95% confidence interval (CI) were extracted to assess the association between herpes zoster and stroke. Results A total of 8 articles were included in our analysis. The present meta-analysis showed that the risks of stroke after herpes zoster were 2.36 (95% CI: 2.17–2.56) for first 2 weeks, 1.56 (95% CI: 1.46–1.66) for first month, 1.17 (95% CI: 1.13–1.22) for first year, and 1.09 (95% CI: 1.02–1.16) for more than 1 year, respectively. Conclusion The results of our study demonstrated that herpes zoster was associated with a higher risk of stroke, but the risks decreased along with the time after herpes zoster. PMID:27768762

  16. Clinical Observation on Therapeutic Effect of Ji De Sheng She Yao Tablet on 16 Cases with AIDS Complicated by Herpes Zoster

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@The Ji De Sheng She Yao tablet (季德胜蛇药片)is a drug for snake-bites and insect bites. According to recent reports, this drug has been used to treat herpes zoster, hepatitis B, parotitis, nephrotic syndrome, acute conjunctivitis, recurrent aphtha, urticaria, etc.1 with good therapeutic effects. More than half of the AIDS patients suffered from herpes zoster. The area of skin lesion in AIDS patients is larger than that of the patients without AIDS and the pain lasts longer. Many cases have keloids and depigmentation for months, even severe pain till their death. Routine therapeutic methods are not satisfactory in therapeutic effects. The expert group of traditional Chinese medicine for cooperative research on AIDS used Ji De Sheng She Yao tablets (季德胜蛇药片) to treat AIDS complicated by herpes zoster for the first time and the results are reported as follows.

  17. Cost-effectiveness of vaccination against herpes zoster.

    Science.gov (United States)

    de Boer, Pieter T; Wilschut, Jan C; Postma, Maarten J

    2014-01-01

    Herpes zoster (HZ) is a common disease among elderly, which may develop into a severe pain syndrome labeled postherpetic neuralgia (PHN). A live-attenuated varicella zoster virus vaccine has been shown to be effective in reducing the incidence and burden of illness of HZ and PHN, providing the opportunity to prevent significant health-related and financial consequences of HZ. In this review, we summarize the available literature on cost-effectiveness of HZ vaccination and discuss critical parameters for cost-effectiveness results. A search in PubMed and EMBASE was performed to identify full cost-effectiveness studies published before April 2013. Fourteen cost-effectiveness studies were included, all performed in western countries. All studies evaluated cost-effectiveness among elderly above 50 years and used costs per quality-adjusted life year (QALY) gained as primary outcome. The vast majority of studies showed vaccination of 60- to 75-year-old individuals to be cost-effective, when duration of vaccine efficacy was longer than 10 years. Duration of vaccine efficacy, vaccine price, HZ incidence, HZ incidence and discount rates were influential to the incremental cost-effectiveness ratio (ICER). HZ vaccination may be a worthwhile intervention from a cost-effectiveness point of view. More extensive reporting on methodology and more detailed results of sensitivity analyses would be desirable to address uncertainty and to guarantee optimal comparability between studies, for example regarding model structure, discounting, vaccine characteristics and loss of quality of life due to HZ and PHN.

  18. Varicella-zoster virus-specific enzyme-linked immunospot assay responses and zoster-associated pain in herpes zoster subjects.

    Science.gov (United States)

    Tyring, Stephen K; Stek, Jon E; Smith, Jeffrey G; Xu, Jin; Pagnoni, Marco; Chan, Ivan S F; Silber, Jeffrey L; Parrino, Janie; Levin, Myron J

    2012-09-01

    Varicella-zoster virus (VZV)-specific cell-mediated immunity (CMI) responses were compared over time following an episode of herpes zoster (HZ) with those of age-, race-, and gender-matched healthy controls (HC) without HZ, using a validated gamma interferon (IFN-γ) enzyme-linked immunospot (ELISPOT) assay. The zoster brief-pain inventory (ZBPI) was used to assess zoster-associated pain. HZ patients (n = 140) had significantly higher IFN-γ ELISPOT responses to VZV antigen than did HC (n = 140). ELISPOT geometric mean count (GMC) responses (with 95% confidence intervals [CI]) for subjects who presented within 72 h were as follows: for HZ patients ≥ 60 years of age, at day 0 the GMC was 110 and at week 2 the GMC was 235; for HZ patients 21 to 59 years of age, at day 0 the GMC was 111 and at week 2 the GMC was 198; for HC ≥ 60 years of age, at day 0 the GMC was 19 and at week 2 the GMC was 18; and for HC 21 to 59 years of age, at day 0 the GMC was 59 and at week 2 the GMC was 56. The mean pain score (95% CI) across age groups at 1 week postrash (n = 106) was 6.0 (5.5, 6.5) and at 2 weeks postrash (n = 119) was 3.5 (2.9, 4.0). The percentage of HZ patients with substantial pain (score ≥ 3) at 6 weeks postrash increased with age from 8% for patients 21 to 49 years of age to 16% for patients 50 to 59 years of age to 22% for patients ≥ 60 years of age. The VZV-specific CMI response was substantially boosted by an episode of HZ, as measured by ELISPOT results. Older adults had lower VZV-specific cellular immunity than younger subjects at baseline, but the boosting effect of HZ was substantial for all age groups. HZ patients experienced considerable zoster-associated acute (1 to 2 weeks after rash) pain across age groups, while chronic pain increased with age.

  19. Hospital admissions for herpes zoster in Portugal between 2000 and 2010.

    Science.gov (United States)

    Mesquita, Margarida; Froes, Filipe

    2013-01-01

    Introdução e Objectivos: O aumento da incidência de herpes zoster e da nevralgia pós-herpética estão associados ao envelhecimento da população. Estas patologias podem ser francamente debilitantes e ter um grande impacto na qualidade de vida dos doentes. Numa população envelhecida como a portuguesa, é esperado que o impacto do herpes zoster e da post-herpetic neuralgia aumentem. No entanto, não existe no país nenhum sistema específico de monitorização da doença e não foram encontrados dados epidemiológicos portugueses nas últimas décadas. A vacina contra o herpes zoster, já recomendada noutros países europeus, ainda não se encontra disponível em Portugal. Conhecer o impacto do herpes zoster é importante para fundamentar medidas de saúde pública relacionadas com a vacinação.Material e Métodos: Procedeu-se a uma análise retrospetiva da base de dados da Administração Central dos Sistemas de Saúde com a informação clínica codificada dos internamentos hospitalares de todos os indivíduos com o diagnóstico principal de herpes zoster (ICD-9-CM 053) e que tiveram alta entre 2000 e 2010.Resultados: Em Portugal, entre 2000 e 2010, ocorreram 1 706 internamentos hospitalares com o diagnóstico principal de herpes zoster. A maioria dos doentes era idosa. Do total de internados, 10,6% tinham formas potencialmente graves de imunocompromisso. A doença predominante de herpes zoster sem complicações, seguido de herpes zoster do sistema nervoso e oftálmico. A duração média dos internamentos foi de 9,3 dias, aumentando com a idade. A letalidade intra-hospitalar foi de 1%. Considerando o período de 2000-2009 e apenas a população adulta, a média anual da incidência dos internamentos hospitalares com o diagnóstico principal deherpes zoster foi de 1,9 por 100 000 habitantes, aumentando com a idade.Conclusão: Este estudo confirma que, em Portugal, as formas graves de herpes zoster estão relacionadas com a idade e associadas a

  20. Evaluation of Chosen Cytokine Levels among Patients with Herpes Zoster as Ability to Provide Immune Response.

    Directory of Open Access Journals (Sweden)

    Agata Zajkowska

    Full Text Available Herpes zoster is a viral disease caused by the reactivation of varicella-zoster virus (VZV which remained latent in the cranial nerve or dorsal root ganglia. Cell-mediated immunity is known to decline with age as part of immunosenescence and can lead to the reactivation of VZV. Whereas herpes zoster is usually mild in healthy young persons, older patients are at increased risk for complications. In the present study we investigated the serum cytokine profile (IL-17, IL-23, IL-21, IL-4, IL-12, representing cellular and humoral immunity and assessed the level of VZV IgG antibodies in patients with herpes zoster.We investigated the serum concentrations of IL-17, IL-23, IL-21, IL-4, IL-12 and the level of VZV IgG antibodies in 23 patients with herpes zoster who did not develop superinfection. The control group was represented by 21 individuals in similar age with no inflammatory and infectious diseases. Cytokine and antibodies levels were measured by ELISA method. Statistical analysis was performed using the ROC curve (receiver operating characteristic, t-test, Welch's t-test, and nonparametric tests with STATISTICA 10 software.In patients with herpes zoster, the serum level of IL-17, IL-23, IL-21, IL-4 and IL-12 as well as VZV IgG antibodies titer were statistically significantly increased compared to control group.Our results confirm the broad activation of the immune system involving humoral and cell-mediated immunity.

  1. Providers' lack of knowledge about herpes zoster in HIV-infected patients is among barriers to herpes zoster vaccination.

    Science.gov (United States)

    Aziz, M; Kessler, H; Huhn, G

    2013-06-01

    Identification of perceptions about herpes zoster (HZ) disease, vaccine effectiveness and safety, and vaccine recommendations may impact immunization practices of physicians for HIV-infected patients. A survey was used to quantify knowledge of HZ as well as determine physician immunization perceptions and practices. There were 272/1700 respondents (16%). Correct answers for the incidence of varicella zoster virus (VZV) infection in adults and incidence of HZ in HIV-infected patients were recorded by 14% and 10% of providers, respectively. Providers reported poor knowledge of the incidence of disease recurrence in HIV-infected patients (41% correct), potency of HZ vaccine (47.5% correct) and mechanism of protection against reactivation of VZV (66% correct). Most (88%) agreed that HZ was a serious disease, and 73% believed that the burden of disease made vaccination important. A majority (75%) did not vaccinate HIV patients with HZ vaccine regardless of antiretroviral therapy status. Barriers to administration included safety concerns, concern that vaccine would not prevent HZ, risk of HZ dissemination, reimbursement issues and lack of Infectious Diseases Society of America (IDSA) guidelines. Only 38% of providers agreed that CDC guidelines were clear and 50% believed that clinical trials were needed prior to use of HZ vaccine in HIV-infected patients. Education about HZ is needed among HIV providers. Providers perceived vaccination as important, but data on vaccine safety and clear guidance from the CDC on this issue are lacking.

  2. Concurrent Reactivation of Herpes Simplex and Varicella Zoster Viruses Confirmed by the Loop-Mediated Isothermal Amplification Assay

    Directory of Open Access Journals (Sweden)

    Tsukane Kobayashi

    2014-01-01

    Full Text Available Concurrent reactivation of herpes simplex and varicella zoster viruses is rare. Here, we describe the case of an elderly patient with herpes labialis and herpes zoster manifesting as a right-side facial eruption with vesicles and crusting. The loop-mediated isothermal amplification (LAMP assay demonstrated the presence of both herpes simplex virus type 1 and varicella zoster virus in swab samples taken from the face, which was confirmed by real-time PCR, suggesting concurrent reactivation of both viruses. The use of the LAMP assay in the present case indicates its usefulness in the diagnosis of atypical herpes infections.

  3. 自拟带状疱疹止痛液治疗带状疱疹%Since the quasi liquid treatment of herpes zoster herpes zoster pain

    Institute of Scientific and Technical Information of China (English)

    李红

    2015-01-01

    objective to study the matching ribbon spore rash analgesic liquid clinical curative effect for the treatment of herpes zoster.Methods select to our hospital patients with herpes zoster, imposing from herpes zoster pain, observe its clinical effect after using.results of herpes seven appears to apply to parts which have very good anti-infiammation, detumescence and hygroscopic raw muscle, analgesic effect, quickly eliminate pathological symptom such as acid, hemp, swollen and painful.the clinical practice the effective rate was 100%.conclusion from herpes zoster pain liquid for the treatment of herpes zoster has significant curative effect, can be widely used in clinical.%目的:研究自拟带状孢疹止痛液治疗带状疱疹的临床疗效。方法选取来我院就诊的带状疱疹患者,对其施以自拟带状疱疹止痛液,观察其使用后的临床效果。结果七药合用外敷于起疱疹的部位可起到很好的抗炎、消肿、收湿生肌、止痛的效果,迅速消除酸、麻、肿、痛等病理症状。经临床实践其有效率为100%。结论自拟带状疱疹止痛液对于带状疱疹的治疗有显著疗效,可在临床当中广泛应用。

  4. Herpes zoster: Epidemiología y clínica Clinical and epidemiological aspects of Herpes zoster

    Directory of Open Access Journals (Sweden)

    Claudia Vujacich

    2008-04-01

    Full Text Available El herpes zoster (HZ constituye una enfermedad de distribución mundial; sin embargo, existen es casos datos comunicados sobre la misma en países de Latinoamérica. Con el objetivo de evaluar aspectos clínicos y epidemiológicos de esta enfermedad en nuestra población, realizamos un análisis retrospectivo de historias clínicas de un centro privado de referencia en enfermedades infecciosas en Buenos Aires, Argentina (período: 2000-2005. Se realizó un análisis estadístico univariado para evaluar los factores asociados a neuralgia posherpética en este grupo de pacientes. Sobre un total de 302 casos evaluables, el 62% correspondieron a mujeres. La mediana de edad fue de 57 años. El 16.1% de los pacientes presentó condiciones predisponentes al desarrollo de zoster. Las localizaciones más frecuentes fueron la torácica, oftálmica y lumbosacra. El 7.75% presentó compromiso de más de dos metámeras. El 94% de los pacientes recibió medicación antiviral, siendo el aciclovir la droga más utilizada. El 94% recibió alguna medicación coadyuvante (antiinflamatorios no esteroideos, antineuríticos, corticoides. La complicación más frecuente fue la neuralgia posherpética (12% y se encontró estadísticamente asociada a edad mayor de 50 años.Herpes zoster (HZ is a public health problem worldwide. Although, there is paucity of data of this disease from South American countries. The objective of this study was to evaluate clinical and epidemiological aspects of HZ in a population of patients from South America. We underwent a retrospective analysis of clinical charts of an infectious diseases reference center (period: 2000-2005. Univariate analysis was performed to assess variables related to post herpetic neuralgia (PHN. From a total of 302 cases, 62% were in women. The median age was 57 years; 16.1% of the patients had a predisposing condition for the development of HZ. Most frequent dermatomes involved were: thoracic, ophthalmic and

  5. Association between recent herpes zoster but not herpes simplex infection and subsequent risk of malignancy in women: a retrospective cohort study.

    Science.gov (United States)

    Buntinx, F; Bartholomeeusen, S; Belmans, A; Mathei, C; Opdenakker, G; Sweldens, K; Truyers, C; Van Ranst, M

    2014-05-01

    The association between herpes zoster and subsequent cancer risk is still unclear. Consequently, doubts remain regarding the need for investigation of herpes patients for co-existing or subsequent malignancy. This is a retrospective cohort study comparing cancer risk in patients after herpes zoster and age-/sex-matched non-herpes zoster patients, in a primary care-based continuous morbidity database. We tested for interaction by gender, age, diabetes, HRT use or antiviral therapy. Analyses were repeated for patients with and without herpes simplex. The hazard ratio (HR) comparing cancer risk in herpes zoster vs. control patients was significant in all women, women aged > 65 years and subgroups of breast and colorectal cancer (HRs 1·60, 1·82, 2·14, 2·19, respectively). For men, a significant association was found for haematological cancers (HR 2·92). No associations were found with herpes simplex. No interaction was identified with antiviral therapy, diabetes or HRT treatment. We concluded that there was a moderate significant association between herpes zoster and subsequent cancer risk in women aged > 65 years, without any influence of antiviral therapy. No association was found with herpes simplex. There is insufficient reason for extensively testing older patients with herpes zoster or herpes simplex for the presence of occult cancer.

  6. Acupuncture plus moxibustion for herpes zoster: A systematic review and meta-analysis of randomized controlled trials.

    Science.gov (United States)

    Coyle, Meaghan E; Liang, Haiying; Wang, Kaiyi; Zhang, Anthony Lin; Guo, Xinfeng; Lu, Chuanjian; Xue, Charlie C

    2017-03-24

    Herpes zoster is an acute inflammatory condition which can have a significant impact on quality of life. Antiviral therapies are effective, but do not meet patients' expectations of symptomatic relief. Acupuncture and moxibustion have been used for herpes zoster; this systematic review evaluated their efficacy and safety. Nine English and Chinese databases were searched from their inceptions to March 2016. Randomized controlled trials evaluating the combination of acupuncture plus moxibustion in adult herpes zoster were included. Outcomes included pain intensity and duration, quality of life and adverse events. Meta-analysis was performed using RevMan software (version 5.3). Nine studies (945 participants) were included. Studies were of low to moderate methodological quality based on risk of bias assessment. Pain intensity (visual analogue scale) was lower among those who received acupuncture plus moxibustion compared with pharmacotherapy (one study; MD -8.25 mm, 95% CI -12.36 to -4.14). The clinical significance of this result is yet to be established. Some benefits were seen for other pain and cutaneous outcomes, and global improvement in symptoms. Mild adverse events were reported in the intervention groups. Acupuncture plus moxibustion may improve pain and cutaneous outcomes, although current evidence is limited by the number of studies and methodological shortcomings.

  7. Varicella and Herpes Zoster in Madrid, based on the Sentinel General Practitioner Network: 1997–2004

    Directory of Open Access Journals (Sweden)

    Gutiérrez-Rodríguez Ángeles

    2007-06-01

    Full Text Available Abstract Background Varicella (chickenpox is the primary disease caused by varicella-zoster virus. It is extremely contagious and is frequent in children. Indeed, in the absence of vaccination, a high proportion of the population is liable to contract it. Herpes zoster -more frequent among adults- is caused by reactivation of the latent virus. The objective of this study is to describe the status of and time trend for varicella and herpes zoster in the Madrid Autonomous Region prior to the introduction of the vaccine to the general population. Methods Data source: individualised varicella and herpes zoster case records kept by the Madrid Autonomous Region Sentinel General Practitioner Network for the period 1997–2004. Cumulative incidences, crude and standardised incidence rates, and age-specific rates of varicella and herpes zoster were calculated for each year. Kendall's Tau-b correlation coefficient was calculated to evaluate whether incidence displayed a time trend. Spectral density in the time series of weekly incidences was estimated using a periodogram. Results Standardised annual varicella incidence rates ranged from 742.5 (95% CI: 687.2 – 797.7 to 1239.6 (95% CI: 1164.5 – 1313.4 cases per 100 000 person-years. Most cases affected children, though complications were more frequent in adults. Varicella incidence displayed an annual periodicity but no trend over time. Most herpes zoster cases occurred at advanced ages, with incidence registering a rising annual trend but no seasonality factor. Conclusion In the absence of vaccination, no significant changes in varicella incidence were in evidence recent years, though these were observed in the incidence of herpes zoster. Sentinel general practitioner networks are a valid instrument for surveillance of diseases such as varicella. Further varicella vaccination-coverage and vaccine-efficacy studies are called for.

  8. Functional decline and herpes zoster in older people: an interplay of multiple factors.

    Science.gov (United States)

    2015-12-01

    Herpes zoster is a frequent painful infectious disease whose incidence and severity increase with age. In older people, there is a strong bidirectional link between herpes zoster and functional decline, which refers to a decrement in ability to perform activities of daily living due to ageing and disabilities. However, the exact nature of such link remains poorly established. Based on the opinion from a multidisciplinary group of experts, we here propose a new model to account for the interplay between infection, somatic/psychiatric comorbidity, coping skills, polypharmacy, and age, which may account for the functional decline related to herpes zoster in older patients. This model integrates the risk of decompensation of underlying disease; the risk of pain becoming chronic (e.g. postherpetic neuralgia); the risk of herpes zoster non-pain complications; the detrimental impact of herpes zoster on quality of life, functioning, and mood; the therapeutic difficulties due to multimorbidity, polypharmacy, and ageing; and the role of stressful life events in the infection itself and comorbid depression. This model underlines the importance of early treatment, strengthening coping, and vaccine prevention.

  9. Association of Herpes Zoster and Type 1 Diabetes Mellitus.

    Directory of Open Access Journals (Sweden)

    Hsin-Hung Chen

    Full Text Available The purpose of our study was to determine the association of type 1 diabetes mellitus (T1DM and the risk of herpes zoster (HZ.In this cohort study, we selected 4736 patients with T1DM registered in the Catastrophic Illness Patient Database who received insulin therapy before 2003 and 18944 participants without DM who were selected by frequency matched based on sex and age. Cox proportional hazard regression analysis was used to measure the hazard ratios (HRs of HZ in the T1DM group compared with that in the non-T1DM group.Cox proportional hazard regression analysis showed that the adjusted HR of HZ was 2.38 times higher for patients in the T1DM group (95% CI = 1.77-3.19 than for those in the non-T1DM group. According to diabetes severity, mild and serious T1DM patients were associated with a higher risk of HZ (adjusted HR = 2.26, 95% CI = 1.67-3.05; and adjusted HR = 5.08, 95% CI = 2.66-9.71, respectively than subjects without T1DM.Patients with T1DM are at a higher risk of HZ than those without T1DM.

  10. Evaluation of the economic burden of Herpes Zoster (HZ) infection.

    Science.gov (United States)

    Panatto, Donatella; Bragazzi, Nicola Luigi; Rizzitelli, Emanuela; Bonanni, Paolo; Boccalini, Sara; Icardi, Giancarlo; Gasparini, Roberto; Amicizia, Daniela

    2015-01-01

    The main objective of this systematic review was to evaluate the economic burden of Herpes Zoster (HZ) infection.   The review was conducted in accordance with the standards of the "Preferred Reporting Items for Systematic Reviews and Meta-Analyses" guidelines. The following databases were accessed: ISI/Web of Knowledge (WoS), MEDLINE/PubMed, Scopus, ProQuest, the Cochrane Library and EconLit. Specific literature on health economics was also manually inspected. Thirty-three studies were included. The quality of the studies assessed in accordance with the Consolidated Health Economic Evaluation Reporting Standards checklist was good. All studies evaluated direct costs, apart from one which dealt only with indirect costs. Indirect costs were evaluated by 12 studies. The economic burden of HZ has increased over time. HZ management and drug prescriptions generate the highest direct costs. While increasing age, co-morbidities and drug treatment were found to predict higher direct costs, being employed was correlated with higher indirect costs, and thus with the onset age of the disease. Despite some differences among the selected studies, particularly with regard to indirect costs, all concur that HZ is a widespread disease which has a heavy social and economic burden.

  11. Herpes zoster vaccination in the elderly subjects: improving awareness and uptake

    Directory of Open Access Journals (Sweden)

    Stefanati A

    2015-10-01

    Full Text Available Armando Stefanati, Nicoletta Valente, Silvia Lupi, Sara Previato, Matilde Giordani, Giovanni Gabutti Department of Medical Sciences, University of Ferrara, Ferrara, Italy Abstract: Herpes zoster (HZ is a common disease in adults and older subjects solely related to the reactivation of latent varicella zoster virus in ganglia. The incidence of the disease increases with aging and the decline of varicella zoster virus-specific cell-mediated immunity. HZ has a significant impact on the quality of life of subjects during the acute phase. Besides, pain can persist even for a long time becoming chronic. The chronic pain following HZ is called postherpetic neuralgia, and it is a debilitating long-lasting condition, characterized by metameric pain, allodynia, and hyperalgesia. Therapeutic options against HZ and postherpetic neuralgia are often suboptimal and the impact of the disease and its complications on daily living activities is significant, especially in older subjects. Nowadays, a preventive approach to the disease is possible; as a matter of fact, a high-antigen content live vaccine is available. This vaccine has a good profile in terms of immunogenicity, efficacy, effectiveness, and safety and its use may prevent both HZ and postherpetic neuralgia. Nevertheless, the evaluation of the issues raised in countries that introduced this immunization show that both provider and patient barriers could have prevented a more robust uptake of HZ vaccination. In the USA, HZ immunization storage was expensive, reimbursement was cumbersome, and supply shortages may have limited promotion by the interests of the manufacturer and provider. The doctors did not actively recommend HZ vaccination; on the other hand, subjects were mostly unaware of the HZ vaccine. Several demographic factors, including sex and educational level, could have negatively affected the coverage rates; besides, the clinicians who treat adults focus less on vaccination than those taking

  12. Expression of varicella-zoster virus and herpes simplex virus in normal human trigeminal ganglia

    Energy Technology Data Exchange (ETDEWEB)

    Vafai, A.; Wellish, M.; Devlin, M.; Gilden, D.H. (Univ. of Colorado School of Medicine, Denver (USA)); Murray, R.S. (Univ. of Colorado School of Medicine, Denver (USA) Veterans Administration Medical Center, Denver, CO (USA))

    1988-04-01

    Lysates of radiolabeled explants from four human trigeminal ganglia were immunoprecipitated with antibodies to varicella-zoster virus (VZV) and to herpes simplex virus. Both herpes simplex virus- and VZV-specific proteins were detected in lysates of all four ganglia. Absence of reactivity in ganglion explants with monoclonal antibodies suggested that herpes simplex virus and VZV were not reactivated during the culture period. In situ hybridization studies demonstrated the presence of RNA transcripts from the VZV immediate early gene 63. This approach to the detection of herpes simplex virus and VZV expression in human ganglia should facilitate analysis of viral RNA and proteins in human sensory ganglia.

  13. Herpes Zoster Induced Osteomyelitis in the Immunocompromised Patients: A 10-year Multicenter Study

    Directory of Open Access Journals (Sweden)

    Reza Tabrizi

    2014-09-01

    Full Text Available Statement of the Problem: Alveolar bone necrosis induced by Herpes zoster infection is considered as a rare manifestation of osteomyelitis and few case reports are presented in the literature. Purpose: The aim of this study was to evaluate mandibular osteomyelitis caused by herpes zoster in the immunocompromised patients with histopathologically documented osteomyelitis in the mandible and herpes zoster infection. Materials and Method: 30 patients were recruited in this cross-sectional study. 19 patients were completely edentulous, 4 patients were partially edentulous and 7 with complete dentition. In all cases, specimens were analyzed using a conventional polymerase chain reaction (PCR test for varicella zoster virus. Results: 16 patients underwent dialysis, 9 patients received chemotherapy treat-ments and 5 patients had transplantation (four kidneys and one liver. Histopa-thological assessment demonstrated a nonspecific bone necrosis exhibiting an eosinophilic, homogeneous non-vital bone tissue with peripheral resorption sur-rounded by reactive connective tissue. PCR test was positive in 21 cases. Conclusion: This study demonstrated that the frequency of osteomyelitis induced by herpes zoster could be more than the records provided by previous studies. Histopathological findings might be nonspecific in such patients. PCR test was not positive for all HZ induced osteomyelitis patients.

  14. The impact of herpes zoster and post-herpetic neuralgia on quality-of-life

    Directory of Open Access Journals (Sweden)

    Schmader Kenneth E

    2010-06-01

    Full Text Available Abstract Background The potentially serious nature of herpes zoster (HZ and the long-term complication post-herpetic neuralgia (PHN are often underestimated. One in four people will contract herpes zoster in their lifetime, with this risk rising markedly after the age of 50 years, and affecting one in two in elderly individuals. Pain is the predominant symptom in all phases of HZ disease, being reported by up to 90% of patients. In the acute phase, pain is usually moderate or severe, with patients ranking HZ pain as more intense than post-surgical or labour pains. Up to 20% of patients with HZ develop PHN, which is moderate-to-severe chronic pain persisting for months or years after the acute phase. We review the available data on the effect of HZ and PHN on patients' quality-of-life. Discussion Findings show that HZ, and particularly PHN, have a major impact on patients' lives across all four health domains - physical, psychological, functional and social. There is a clear correlation between increasing severity of pain and greater interference with daily activities. Non-pain complications such as HZ ophthalmicus can increase the risk of permanent physical impairment. Some elderly individuals may experience a permanent loss of independence after an acute episode of HZ. Current challenges in the management of HZ and PHN are highlighted, including the difficulty in administering antiviral agents before pain becomes established and the limited efficacy of pain treatments in many patients. We discuss the clinical rationale for the HZ vaccine and evidence demonstrating that the vaccine reduces the burden of the disease. The Shingles Prevention Study, conducted among >38,000 people aged ≥60 years old, showed that the HZ vaccine significantly reduces the burden of illness and the incidence of both HZ and PHN. In the entire study population, zoster vaccination reduced the severity of interference of HZ and PHN with activities of daily living by two

  15. Frecuencia de infección por VIH en pacientes con episodio agudo de herpes zoster.

    OpenAIRE

    LAZARTE HERAUD, Susana; BRAVO PUCCIO, Francisco; SAMALVIDES CUBA, Frine; Del Solar Chacaltana, Manuel; GUERRA AMAYA, Oscar; VERDONCK BOSTEELS, Kristien; SOLARI SERPA, Lely; GOTUZZO HERENCIA, Eduardo

    2012-01-01

    Objetivo: Evaluar la frecuencia de infección por VIH en pacientes que consultan por episodio agudo de herpes zoster. Material y Métodos: Se incluyeron a todos los pacientes entre 18 y 49 años, atendidos entre setiembre del 2001 y enero del 2003 en el Departamento de Enfermedades Infecciosas, Tropicales y Dermatológicas del Hospital Nacional Cayetano Heredia, por un cuadro agudo de herpes zoster, diagnosticado clínicamente. Los criterios de inclusión fueron: status VIH desconocido tanto del pa...

  16. Localized linear IgA dermatosis induced by UV light-treatment for herpes zoster.

    Science.gov (United States)

    He, Chundi; Xu, Honghui; Xiao, Ting; Geng, Long; Chen, Hong-Duo

    2007-05-01

    We report a case of localized linear IgA dermatosis (LID). The patient suffered from herpes zoster on the right waist and received three localized ultraviolet (UV) light treatments. One month later he presented with bullae on the same site. Direct immunofluorescence showed deposition of linear IgA and weak C3 along the basement membrane zone. Indirect immunofluorescence on the salt-split human skin demonstrated that IgA antibodies were bound to the epidermal side. To our knowledge, this is the first case of localized LID induced by UV light treatment for herpes zoster. It is also the third case of LID induced by UV light.

  17. Herpes Zoster of the Third Division of the Trigeminal Nerve. A Clinical Pathologic Conference.

    Science.gov (United States)

    Doan, Karen; Stoler, Kenneth; Logan, Keri

    2015-11-01

    Herpes zoster of the trigeminal nerve is a disease that often challenges dentists and dental specialists trying to make the proper diagnosis, as many ulcerative and vesiculobullous diseases of the mouth have a similar clinical appearance. We report a clinical case in which a 27-year-old patient sought care for this vesicular lesion. Included are the differential diagnosis and treatment modalities that we used to diagnose the disease. A clinical pathologic conference is provided to highlight the appropriate courses of action in the management of herpes zoster.

  18. Evidence-based interventional pain medicine according to clinical diagnoses. 17. Herpes zoster and post-herpetic neuralgia.

    Science.gov (United States)

    van Wijck, Albert J M; Wallace, Mark; Mekhail, Nagy; van Kleef, Maarten

    2011-01-01

    Herpes zoster infection is caused by a reactivation of the latent varicella zoster virus that causes chicken pox. It appears predominantly in older adults whose immunity for the virus has waned. The natural course of the disease is usually favorable, and the symptoms disappear spontaneously within a few weeks. Some patients, however, have prolonged pain: post-herpetic neuralgia. The diagnosis of acute zoster infection is made on the clinical signs including the appearance of rash. Post-herpetic neuralgia is described as sharp, burning, aching, or shooting constantly present in the dermatome that corresponds with the earlier rash. The objectives of treating herpes zoster are: (1) acute pain reduction; (2) promotion of recovery of epidermal defects and prevention of secondary infections; and (3) reduction or prevention of post-herpetic neuralgia. The objective of the treatment of post-herpetic neuralgia is primarily pain alleviation and improvement of the quality of life. Early treatment of the infection and the pain is believed to reduce the risk for post-herpetic neuralgia. This persistent pain syndrome is difficult to treat. Antiepileptic drugs and tricyclic antidepressants are the first choice. Interventional treatments, such as epidural injections of corticosteroids and local anesthetic drugs, have an effect on the acute pain but are of limited use in preventing post-herpetic neuralgia. When conservative treatment fails in providing satisfactory relief of post-herpetic neuralgia, a sympathetic block may be considered (2 C+); if this treatment provides unsatisfactory results, spinal cord stimulation may be considered, in a study context (2 C+).

  19. MR imaging in Bell's palsy and herpes zoster opticus: correlation with clinical findings

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Jung Ho; Mo, Jong Hyun; Moon, Sung Hee; Lee, Sang Sun; Park, Yang Hee; Lee, Kyung Hee [National Police Hospital, Seoul (Korea, Republic of); Choi, Ik Joon [Sejong General Hospital, Seoul (Korea, Republic of)

    1998-09-01

    To evaluate the MRI findings of acute facial nerve paralysis in Bell's palsy and herpes zoster opticus, and to correlate these with the clinical findings. We retrowspectively reviewed the MRI findings in six cases of BEll's palsy(BP) and two of herpes zoster oticus(HZO), and compared them with the findings for 30 normal facial nerves. This nerve was considered abnormal when its signal intensity was greater than that of brain parenchyma or the contralateral normal side on Gd-enhanced T1-weighted axial and coronal MR images. We analysed the location and degree of contrast enhancement, interval change, and clinical progression in correlation with House-Brackmann(HB) grade and electroneuronography (ENoG) findings. Fifteen of 30 normal facial nerves(50%) seen on Gd-enhanced MRI were mildly enhanced in the geniculate ganglion, the proximal tympanic, and the proximal mastoid segment of the facial nerve. No enhancement of the internal auditory canal(IAC) or labyrinthine segment of the facial nerve was noted, however. In BP and HZO, Gd-enhanced MR images revealed fair to marked enhancement for more than two segments from the internal auditory canal to the mastoid segment of the facial nerve. During follow-up MRI, enhancement of the facial nerve varied in location and signal intensity, though gradually decreased in intensity approximately eight weeks after the onset of facial nerve palsy. No correlation between clinical HB grade, ENoG, and follow up MRI findings was noted. Except in the internal auditory canal and labyrinthine segment, normal facial nevemay show mild and relatively symmetrical enhancement. In BP and HZO, the facial nerve showed diffuse enhancement from the IAC to the mastoid segment.=20.

  20. Evaluation of Chosen Cytokine Levels among Patients with Herpes Zoster as Ability to Provide Immune Response

    Science.gov (United States)

    Zajkowska, Agata; Garkowski, Adam; Świerzbińska, Renata; Kułakowska, Alina; Król, Monika Emilia; Ptaszyńska-Sarosiek, Iwona; Nowicka-Ciełuszecka, Anna; Pancewicz, Sławomir; Czupryna, Piotr; Moniuszko, Anna; Zajkowska, Joanna

    2016-01-01

    Aim and Background Herpes zoster is a viral disease caused by the reactivation of varicella–zoster virus (VZV) which remained latent in the cranial nerve or dorsal root ganglia. Cell-mediated immunity is known to decline with age as part of immunosenescence and can lead to the reactivation of VZV. Whereas herpes zoster is usually mild in healthy young persons, older patients are at increased risk for complications. In the present study we investigated the serum cytokine profile (IL-17, IL-23, IL-21, IL-4, IL-12), representing cellular and humoral immunity and assessed the level of VZV IgG antibodies in patients with herpes zoster. Methods We investigated the serum concentrations of IL-17, IL-23, IL-21, IL-4, IL-12 and the level of VZV IgG antibodies in 23 patients with herpes zoster who did not develop superinfection. The control group was represented by 21 individuals in similar age with no inflammatory and infectious diseases. Cytokine and antibodies levels were measured by ELISA method. Statistical analysis was performed using the ROC curve (receiver operating characteristic), t-test, Welch’s t-test, and nonparametric tests with STATISTICA 10 software. Results In patients with herpes zoster, the serum level of IL-17, IL-23, IL-21, IL-4 and IL-12 as well as VZV IgG antibodies titer were statistically significantly increased compared to control group. Conclusion Our results confirm the broad activation of the immune system involving humoral and cell-mediated immunity. PMID:26934574

  1. STUDY OF HERPES ZOSTER IN HIV PATIENTS IN RELATION TO CD4 COUNT

    Directory of Open Access Journals (Sweden)

    Nivedita Devi

    2015-09-01

    Full Text Available AIMS AND OBJECTIVES: 1. To study herpes zoster in HIV positive patients in relation to CD4 count. 2. To study the various clinical presentations, common sites, and demographic characteristics of herpes zoster in HIV. MATERIALS AND METHODS: A study was conducted on 94 HIV patients with a clinical diagnosis herpes zoster attending DVL OPD of Government General Hospital, Kakinada. Severity of rash was graded depending on the number of lesions as mild (50.Assessment of intensity of pain was done using visual analog scale (VAS, a numerical rating scale marked from 0 to 10 in increasing order of severity. The relation of CD4 count and herpes zoster and complications of zoster were recorded. RESULTS : The maximum incidence of herpes zoster was found in the sexually active age group with higher incidence in males53.1% and ur ban people 55.3%. Patients with severe rash were 57.4% moderate rash 31.9% and mild rash 10.6%. At the time of presentation, majority 51.06% had vesicular rash. The most common symptom was pricking pain followed by burning sensation and stabbing pain. Most of the patients had thoracic dermatome involvement in 51, cer vical in 18, trigeminal nerve in 16and lumbar in 9. Ophthalmic branch the relation of CD4 count and is involved in 7, maxillary in 5 and mandibular in 4. Majority 18 (19.14% were in the CD4 ra nge 200 - 249, 15 between CD4 150 - 199 and 11 between CD4 350 - 399. Complications noted were post herpetic neuralgia, secondary bacterial infection, scarring, conjuntivis, facial palasy and keratitis. Multidermatomal involvement is seen in 15.95%.

  2. Predictive values of prurigo nodularis and herpes zoster for HIV infection and immunosuppression requiring HAART in French Guiana.

    Science.gov (United States)

    Magand, Florence; Nacher, Mathieu; Cazorla, Céline; Cambazard, Frederic; Marie, Dominique Sainte; Couppié, Pierre

    2011-07-01

    Prurigo nodularis and herpes zoster frequently lead to the diagnosis of HIV in tropical areas. The WHO has established a clinical definition of AIDS for undeveloped countries. Prurigo and herpes zoster are both classified as stage 2. The main objective of this study was to compare the level of immunosuppression of patients diagnosed as HIV-positive after consulting for prurigo nodularis or herpes zoster in French Guiana. A retrospective study was conducted including patients consulting at the Department of Dermatology, Cayenne Hospital (French Guiana) for prurigo nodularis or herpes zoster between 1989 and 2007 for which the systematic HIV test was positive. Demographic data and CD4 counts of both groups were compared. Analysis of 346 patients consulting for herpes zoster (n=192) or prurigo nodularis (n=154) led to the discovery of 129 HIV infections. The positive predictive value (PPV) for HIV positivity was 38.5% for herpes zoster and 36% for prurigo nodularis. The median lymphocyte count was 302/mm(3) in herpes zoster and 87/mm(3) in prurigo nodularis (Pimmunosuppression. This questions the pertinence of the WHO clinical classification of AIDS. In the absence of CD4 count, the present results suggest that for patients with prurigo nodularis, antiretrovirals should be initiated without delay.

  3. A comparison of herpes simplex virus type 1 and varicella-zoster virus latency and reactivation

    OpenAIRE

    2015-01-01

    Herpes simplex virus type 1 (HSV-1; human herpesvirus 1) and varicella-zoster virus (VZV; human herpesvirus 3) are human neurotropic alphaherpesviruses that cause lifelong infections in ganglia. Following primary infection and establishment of latency, HSV-1 reactivation typically results in herpes labialis (cold sores), but can occur frequently elsewhere on the body at the site of primary infection (e.g. whitlow), particularly at the genitals. Rarely, HSV-1 reactivation can cause encephaliti...

  4. Unusual formation of keloids after each episode of recurrent herpes zoster in an HIV positive patient

    Directory of Open Access Journals (Sweden)

    Koley Sankha

    2009-01-01

    Full Text Available Herpes Zoster (HZ lesions are well known to heal with keloids. As immunity plays an important role in the development of abnormal scars and keloids, the latter is unusual in HIV where immunity is low. We report a rare case of recurrent HZ in an HIV-positive male where the lesions have healed with formation of keloids in both episodes. Within 50 days of last episode, he had an attack of herpes progenitalis.

  5. Perspectives on optimal control of varicella and herpes zoster by mass routine varicella vaccination.

    Science.gov (United States)

    Betta, Monica; Laurino, Marco; Pugliese, Andrea; Guzzetta, Giorgio; Landi, Alberto; Manfredi, Piero

    2016-03-16

    Herpes zoster arises from reactivation of the varicella-zoster virus (VZV), causing varicella in children. As reactivation occurs when cell-mediated immunity (CMI) declines, and there is evidence that re-exposure to VZV boosts CMI, mass varicella immunization might increase the zoster burden, at least for some decades. Fear of this natural zoster boom is the main reason for the paralysis of varicella immunization in Europe. We apply optimal control to a realistically parametrized age-structured model for VZV transmission and reactivation to investigate whether feasible varicella immunization paths that are optimal in controlling both varicella and zoster exist. We analyse the optimality system numerically focusing on the role of the cost functional, of the relative zoster-varicella cost and of the planning horizon length. We show that optimal programmes will mostly be unfeasible for public health owing to their complex temporal profiles. This complexity is the consequence of the intrinsically antagonistic nature of varicella immunization programmes when aiming to control both varicella and zoster. However, we show that gradually increasing-hence feasible-vaccination schedules can perform better than routine programmes with constant vaccine uptake. Finally, we show the optimal profiles of feasible programmes targeting mitigation of the post-immunization natural zoster boom with priority.

  6. Acyclovir Prophylaxis Reduces the Incidence of Herpes Zoster Among HIV-Infected Individuals: Results of a Randomized Clinical Trial.

    Science.gov (United States)

    Barnabas, Ruanne V; Baeten, Jared M; Lingappa, Jairam R; Thomas, Katherine K; Hughes, James P; Mugo, Nelly R; Delany-Moretlwe, Sinead; Gray, Glenda; Rees, Helen; Mujugira, Andrew; Ronald, Allan; Stevens, Wendy; Kapiga, Saidi; Wald, Anna; Celum, Connie

    2016-02-15

    Human immunodeficiency virus (HIV)-infected persons have higher rates of herpes zoster than HIV-uninfected individuals. We assessed whether twice daily treatment with 400 mg of oral acyclovir reduces the incidence of herpes zoster in a randomized, double-blind, placebo-controlled trial among 3408 persons coinfected with HIV and herpes simplex virus type 2. During 5175 person-years of follow-up, 26 cases of herpes zoster occurred among those assigned acyclovir, compared with 69 cases among those assigned placebo (rates, 1.00 and 2.68/100 person-years, respectively), a relative decrease of 62% (hazard ratio, 0.38; 95% confidence interval, .24-.67; P herpes zoster incidence among HIV-infected persons.

  7. 颈部带状疱疹及带状疱疹后神经痛%Herpes Zoster on the Neck and Neuralgia after Herpes Zoster

    Institute of Scientific and Technical Information of China (English)

    李全成

    2006-01-01

    急性带状疱疹(Acute herpes zoster)是由水痘——带状疱疹病毒(Varicella zoster virus,VZV)感染所致的一种疾病.患者的特征性表现为沿感染神经分布区的局限性疼痛及相应区域内出现节段性、排列成束状簇集水疱的特异性皮肤损害。在急性带状疱疹的病程中,大多数患者的疼痛十分剧烈,故有效地镇痛是治疗该病的重要措施之一。如果患者得不到及时治疗或治疗不当,部分患者,尤其是老年人,疱疹消失后疼痛仍然存在,进而形成带状疱疹后神经痛。

  8. Patient perspective on herpes zoster and its complications: an observational prospective study in patients aged over 50 years in general practice.

    Science.gov (United States)

    Bouhassira, Didier; Chassany, Olivier; Gaillat, Jacques; Hanslik, Thomas; Launay, Odile; Mann, Claude; Rabaud, Christian; Rogeaux, Olivier; Strady, Christophe

    2012-02-01

    Understanding the effect of herpes zoster and zoster-related pain should inform care to improve health-related quality of life in elderly patients. A 12-month, longitudinal, prospective, multicenter observational study conducted in primary care in France enrolled patients aged ≥ 50 years with acute eruptive herpes zoster. Patient-reported zoster-related pain was assessed by validated questionnaires (Douleur Neuropathique en 4 Questions [DN4], Zoster Brief Pain Inventory [ZBPI], and Neuropathic Pain Symptom Inventory [NPSI]) on days 0 and 15, and at months 1, 3, 6, 9, and 12. Health-related quality of life was assessed by the 12-item short-form health survey (SF-12) and the Hospital Anxiety and Depression scale on day 0 and at months 3, 6, and 12. Of 1358 patients included, 1032 completed follow-up. Mean ± standard deviation age was 67.7 ± 10.7 (range, 50-95) years; 62.2% were women. Most patients (94.1%) were prescribed antiviral drugs. The prevalence of zoster-related pain on day 0 and at months 3, 6, 9, and 12 was 79.6%, 11.6%, 8.5%, 7.4%, and 6.0%, respectively. Patients with persistent pain had lower scores on the physical and mental component summaries of the SF-12 and the ZBPI interference score than those without pain. By logistic regression analysis, main predictive factors on day 0 for postherpetic neuralgia at month 3 were age, male sex, ZBPI interference score, Physical Component Summary score of the SF-12, and neuropathic quality of pain (DN4 score ≥ 4). Despite early diagnosis and treatment with antiviral agents, many patients with herpes zoster experience persistent pain and marked long-term reduction in health-related quality of life.

  9. Treatment of 48 Cases of Herpes Zoster by Puncturing Nerve Stem

    Institute of Scientific and Technical Information of China (English)

    倪夕朗; 洪珏

    2008-01-01

    @@ Herpes zoster is a viral disorder involving both nerve and skin simultaneously, with the duration of about 2 to 3 weeks. The author treated 48 cases by puncturing nerve stem in recent years and obtained good therapeutic results. Now it is reported as follows.

  10. Vitamin D is closely linked to the clinical courses of herpes zoster: From pathogenesis to complications.

    Science.gov (United States)

    Chao, Chia-Ter; Chiang, Chih-Kang; Huang, Jenq-Wen; Hung, Kuan-Yu

    2015-10-01

    Vitamin D is renowned for its pleiotropic effects, including but not limited to bone integrity, and it has assumed an important role in the current research era. As vitamin D receptors are present in a variety of human tissues, particularly immune cells, the immunomodulatory potential of vitamin D cannot be overemphasized. Herpes zoster, which presents as grouped cutaneous vesicles over dermatomes or visceral/central nervous system infection in its severe form, has a higher incidence in immune-suppressed patients. Considering the importance of vitamin D in host immunity, we hypothesize that vitamin D acts as an effect-modifier for the entire herpes zoster spectrum with regard to disease susceptibility, manifestation, efficacy of pharmacologic management, and emergent complications during treatment. Moreover, the possibility exists that vitamin D might affect the course of postherpetic neuralgia. In line with this theory, we comprehensively searched the existing herpes zoster literature and provided important insight into the relationship between the disease courses of herpes zoster and vitamin D.

  11. [Analysis on clinical features and treatment of herpes zoster patients hospitalized in real world].

    Science.gov (United States)

    Yuan, Ling-Lian; Wang, Lian-Xin; Xie, Yan-Ming; Yang, Wei; Yang, Zhi-Xin; Zhuang, Yan; Zhang, Yun-Bi

    2014-09-01

    From the hospital information system (HIS) of 20 national grade III-A general hospitals, 2 960 cases of herpes zoster as the research object, analyzes the relations between the general information, syndrome of traditional Chinese medicine (TCM), western medicine combined diseases, the relationship between the solar term and the incidence of herpes zoster, and the combined use of Chinese and western medicine. Among the patients with 46-65 year old has the highest percentage of diseased; admission to general outpatient clinic is the most; the most common medical payment is medicare; combined disease such as hypertension, diabetes and coronary heart disease is more common; early treatment effect of herpes zoster is better than the sequelae; summer and autumn solar term patients is hospitalized more, TCM syndrome is damp heat of liver fire; about drugs, western medicine is the most commonly used vitamin B1 and mecobalamin, traditional Chinese medicine is the most frequently used Danhong injection, combination therapy with promoting blood circulation drugs and neurotrophic drugs. Thus, herpes zoster, more common in elderly patients, with no obvious relationship between solar term, should be early diagnosis and early treatment, often with combination of Chinese traditional and western medicine treatment.

  12. Do herpes zoster patients receive antivirals?: a national survey in general practice.

    NARCIS (Netherlands)

    Opstelten, W.; Essen, G.A. van; Moons, K.G.M.; Wijck, A.J.M. van; Schellevis, F.G.; Kalkman, C.J.; Verheij, T.J.M.

    2005-01-01

    BACKGROUND: The main complications of herpes zoster (HZ) are postherpetic neuralgia and, in case of HZ ophthalmicus, eye disorders. Antiviral treatment may modify the course of disease and reduce the risk of complications. OBJECTIVE: To assess which doctors' and patients' characteristics were relate

  13. Determinants of non-compliance with herpes zoster vaccination in the community-dwelling elderly

    NARCIS (Netherlands)

    Opstelten, Wim; van Essen, Gerrit A; Hak, Eelko

    2009-01-01

    As part of a series of studies on vaccine acceptance, we assessed determinants of compliance of the community-dwelling elderly with herpes zoster (HZ) vaccination in an existing influenza vaccination program. General practitioners (GPs) sent out a questionnaire to 1778 patients aged > or =65 years,

  14. Effect of acyclovir and steroid in a young immunocompetent male with herpes zoster myelitis

    DEFF Research Database (Denmark)

    El-Safadi, Louay; Arngrim, Nanna; Amin, Faisal Mohammad

    2014-01-01

    Herpes zoster myelitis is a rare condition, usually seen in aged and immunocompromised patients. Due to atypical presen-tations it can be hard to diagnose. Intraspinal lesions on magnetic resonance imaging (MRI) support the diagnosis. We present a 39-year-old otherwise healthy male with symptoms ...

  15. Three cases of herpes zoster radiculitis in MS patients treated with natalizumab.

    Science.gov (United States)

    Yamout, Bassem I; Abou Zeid, Nuhad; Taha, Ali J; Zeineddine, Maya M; Khoury, Samia J

    2016-09-01

    Natalizumab was the first FDA-approved monoclonal antibody for the treatment of multiple sclerosis (MS). We report on 3 natalizumab-treated patients who developed herpes zoster infections. In addition to progressive multifocal leukoencephelopathy, other opportunistic infections have been rarely reported during Natalizumab treatment. We believe that clinicians need heightened awareness of these infections in view of the risks of serious complications.

  16. Oro-Facial Herpes Zoster: A Case Report With A Detailed Review Of Literature

    Directory of Open Access Journals (Sweden)

    Satyaranjan Mishra

    2013-01-01

    Full Text Available Herpes zoster or shingles is a reactivation of the Varicella zoster virus that entered the cutaneous nerve endings during an earlier episode of chicken pox, travelled to the dorsal root ganglia, and remained in a latent form. Nerves most commonly involved are C3, T5, L1, L2 and first division of trigeminal nerve. The condition is characterized by occurrence of multiple, painful, unilateral vesicles and ulceration which shows a typical single dermatome involvement. The infection usually affects elderly individuals, and if present in the younger age group, immune-compromised status such as HIV/AIDS may be suspected. In this case report we present a patient with herpes zoster involving the maxillary and mandibular divisions of the trigeminal nerve, with unilateral vesicles over the left side of lower and middle 1/3rd of face along the trigeminal nerve tract, with intraoral involvement of buccal mucosa, labial mucosa and the palate of the same side.

  17. Diagnosis and management of herpes zoster by the family and community physician

    Directory of Open Access Journals (Sweden)

    Pedro Alexandre Barreto Coelho

    2014-08-01

    Full Text Available The herpes virus that causes varicella (chickenpox persists in a latent form in the nervous system and can reactivate and propagate through nerve roots, manifesting years later through painful skin lesions, a condition called herpes zoster. The diagnosis is primarily clinical, but it is important to make a differential diagnosis with impetigo, contact dermatitis, dermatitis herpetiformis and also herpes simplex itself. After the diagnosis is confirmed, treatment should be initiated within the first 72 hours after onset of the rash and it is based upon antiviral therapy. Valacyclovir and famciclovir are more effective when compared to acyclovir. The most common complication of herpes zoster is post-herpetic neuralgia, usually managed with tricyclic antidepressants, anticonvulsants, topical lidocaine or capsaicin. Recently, a live attenuated vaccine against herpes zoster was introduced in Brazil, with the same components as the vaccine against varicella, but in a greater concentration. However, it still has a high cost and is not available in the public health system.

  18. Treatment of 60 Cases of Senile Herpes Zoster by Encircled Acupuncture plus Valaciclovir

    Institute of Scientific and Technical Information of China (English)

    HE Ying-dan; FANG Rui-hua; KUAI Le

    2007-01-01

    To observe the clinical therapeutic effect and safety of local encircled acupuncture plus valaciclovir in treating senile herpes zoster.Methods:Sixty senile patients with herpes zoster were divided into two groups.In acupuncture and medicine group,the patients were treated by encircled acupuncture plus valaciclovir.The needle was inserted about 0.8 cun away from herpes and to form an angle of 15°with the skin around the skin lesion.During treatment,valaciclovir was taken orally 300 mg every time,twice every day for successive 10 days.In westem medicine group,valaciclovir was taken orally 300 mg every time,twice every day for successive 10 days.Results:The time of stopping herpes,relieving pain andscabbing in acupuncture and medicine group was significantly lower than that in western group.Conclusion:Local encircled acupuncture plus valaciclovir in treating senile herpes zoster got effects quickly and could effectively shorten the course of disease and reduce the incidence rateofresidual neuralgia.

  19. The relationship between T lymphocyte subsets changes and the zoster associated pain in aged patients with acute herpes zoster%老年带状疱疹患者急性期T细胞亚群变化及其与疱疹相关性疼痛的关系

    Institute of Scientific and Technical Information of China (English)

    安尔丹; 肖旺频; 周宗立; 孙丽

    2011-01-01

    目的 检测老年带状疱疹患者急性期外周血T细胞亚群水平,观察患者急性期机体细胞免疫状态与带状疱疹急性期疼痛(AHP)和后遗神经痛(PHN)的关系。 方法 选择急性期老年带状疱疹患者60例,根据AHP视觉模拟评分(visual analogue scales,VAS)分为轻中度AHP组:VAS评分≤6分,重度AHP组:VAS评分>6分;再根据随访结果是否发生带状疱疹后PHN分为非PHN组和PHN组。选取年龄、性别相匹配的门诊健康体检者25例作为对照组。记录患者AHP最严重时VAS评分,采用流式细胞测定技术测定急性期外周血T细胞亚群CD3+、CD4+和CD8+百分比及计算CD4 +/CD8+比值。 结果 各组年龄、性别差异无统计学意义(P>0.05);轻中度AHP组、重度AHP组、非PHN组和PHN组CD3+、CD4+、CD8+表达与对照组比较均降低(P<0.05),重度AHP组CD4+表达低于轻中度AHP组(P<0.05) ;CD4 +/CD8+比值轻中度AHP组、非PHN组均高于对照组(P<0.05),重度AHP组低于轻中度AHP组(P<0.05),PHN组低于非PHN组(P<0.05);PHN组AHP VAS评分高于非PHN组(P<0.05)。 结论 老年带状疱疹患者急性期普遍存在细胞免疫功能低下,表现为T细胞亚群百分比降低;重度AHP患者细胞免疫状态更低。PHN患者在疱疹急性期存在更严重的局部损害和更低下免疫应答。%Objective To study T lymphocyte subsets levels in acute zoster patients and investigate its relation to the zoster associated pain.Methods According to the visual analogue scales(VAS) in the acuter phase, 60 patients with herpes zoster were divided into two groups: group A (VAS≤6) and group B (VAS>6). According to the follow-up results, patients were divided into another two groups: group C (PHN not developed) and group D (PHN developed). 25 healthy volunteers with a similar age and gender range as the patients were recruited as control group. T lymphocyte subsets were detected by fluorescence-activated cell sorter

  20. Is peptic ulcer disease a risk factor of postherpetic neuralgia in patients with herpes zoster?

    Science.gov (United States)

    Chen, Jen-Yin; Chang, Chia-Yu; Lan, Kuo-Mao; Sheu, Ming-Jen; Lu, Chin-Li; Hu, Miao-Lin

    2013-11-01

    Postherpetic neuralgia is the most common complication of herpes zoster which is caused by a reactivation of latent varicella zoster virus. The pathogenesis of postherpetic neuralgia may involve peripheral and central mechanisms. Reported risk factors for postherpetic neuralgia include female gender, old age, diminished cell-mediated immunity and nutritional deficiencies. Based on our clinical observation which revealed that peptic ulcer disease (PUD) is one of the common comorbidities in patients with postherpetic neuralgia, we hypothesize that herpes zoster patients with PUD may be at a greater risk for the development of postherpetic neuralgia due to their impaired cellular immunity and depressed nutritional status. Major causes of PUD include Helicobacter pylori infection and usage of ulcerogenic medications. Patients with H. pylori infection may develop T cell dysfunctions and nutritional deficiencies including vitamin C, iron, cobalamin, carotenes and alpha-tocopherol. Ulcerogenic medications such as nonsteroidal anti-inflammatory drugs and steroids have been found not only to be ulcerogenic but also immunosuppressive to T cells. In addition, usage of steroids and nonsteroidal anti-inflammatory drugs may cause deficiencies of alpha-tocopherol, carotenes, cobalamin, iron, zinc and vitamin C. Vitamin C, carotenes and alpha-tocopherol are anti-inflammatory and the major oxidant scavengers in the aqua phase and biomembranes. Deficiencies of these nutrients may induce dysregulated inflammation and oxidative damage leading to neuropathic pain in patients with herpes zoster. Furthermore, nutrient deficiencies including zinc, iron, cobalamin and vitamin C are associated with dysregulation of Ca(v)3.2 T-channels and N-methyl-D-aspartate receptors, upregulation of nitric oxide synthase, the increase of nitric oxide formation and dysfunction of central norepinephrine inhibitory pain pathway. Prospective cohort studies are suggested to test the hypothesis. We further

  1. Characteristics of hearing loss in patients with herpes zoster oticus.

    Science.gov (United States)

    Kim, Chang-Hee; Choi, Hyerang; Shin, Jung Eun

    2016-11-01

    Patients with herpes zoster oticus (HZO) may commonly show symptoms associated with 7th and 8th cranial nerve (CN VII and CN VIII) dysfunction. The aim of this study is to investigate the characteristics of hearing loss in patients with HZO and discuss possible mechanisms.Ninety-five HZO patients who showed at least one of the symptoms of CN VII and CN VIII dysfunction between January 2007 and October 2014 were included in this study. Hearing loss was defined when the mean thresholds of pure tone audiometry (PTA) in speech frequency (0.5 kHz + 1 kHz + 2 kHz/3) or isolated high frequency (4 kHz + 8 kHz/2) were greater than 10 dB in the affected ear compared with the healthy ear, and a total of 72 patients were classified as the hearing loss group.The difference of mean PTA thresholds between affected and healthy ears was significantly greater in the high frequency range than in low range (20.0 ± 11.5 dB vs. 12.9 ± 15.7 dB, P = 0.0026) in patients with hearing loss (n = 72). The difference between affected and healthy ear was significantly greater in patients with vertigo (n = 34) than those without vertigo (n = 38) in both the high (P = 0.033) and low (P = 0.024) frequency ranges. In contrast, the differences between affected and healthy ears were not significantly different between patients with facial palsy (n = 50) and those without facial palsy (n = 22) in both the high (P = 0.921) and low (P = 0.382) frequency ranges.In patients with HZO, hearing loss is more severe in the high frequency range than in the low frequency range. Hearing impairment is more severe in patients with vertigo than in those without vertigo in both the high and low frequency ranges, even though the degree of hearing impairment is not significantly different between patients with and without facial palsy. These findings indicate that the mechanisms of viral spread from CN VII to CN VIII may differ between

  2. Lymphopaenia, anti-Ro/anti-RNP autoantibodies, renal involvement and cyclophosphamide use correlate with increased risk of herpes zoster in patients with systemic lupus erythematosus.

    Science.gov (United States)

    Hu, Stephen Chu-Sung; Lin, Chi-Ling; Lu, Yi-Wei; Chen, Gwo-Shing; Yu, Hsin-Su; Wu, Ching-Shuang; Lan, Cheng-Che E

    2013-05-01

    Herpes zoster occurs with increased frequency in patients with systemic lupus erythematosus (SLE). The aim of this study was to identify and evaluate clinical and laboratory risk factors associated with development of herpes zoster in patients with SLE. A retrospective case-control study was performed in a population of patients with SLE. Patients were identified as cases if their first episode of herpes zoster occurred after diagnosis of SLE. Patients with SLE who never developed herpes zoster were enrolled as controls. Medical charts and laboratory data for both cases and control patients were comprehensively reviewed. A total of 65 cases and 105 controls were included. Risk factors associated with the development of herpes zoster in patients with SLE were found to be lymphopaenia, anti-Ro antibodies, anti-RNP antibodies, neuropsychiatric manifestations, renal involvement and cyclophosphamide use. Therefore, the presence of certain disease manifestations in patients with SLE represents risk factors for the development of herpes zoster.

  3. Evaluation of sorivudine (BV-araU) versus acyclovir in the treatment of acute localized herpes zoster in human immunodeficiency virus-infected adults

    NARCIS (Netherlands)

    Bodsworth, NJ; Boag, F; Burdge, D; Genereux, M; Borleffs, JCC; Evans, BA; Modai, J; Colebunders, R; Thomas, M; DeHertogh, D; Pacelli, L; Thomis, J; Knight, E.L.; McNulty, AM; Delaney, C; VanHove, D; Sacks, S; Gage, L; McLeod, A; DiazMitoma, F; Fong, J; MacFadden, D; Martel, A; Rachlis, A; Salit, [No Value; Shafran, S; Szabo, J; Toma, E; Deschenes, L; Gill, J; Lalonde, R; Kaufhold, R; Molina, JM; Dellamonica, P; Rozenbaum, W; Kolsters, FP; Meenhorst, PL; Danner, S; Sprenger, HG; EllisPegler, RB; Moragas, J; Moyle, G; Colman, J; Parnell, A; McLean, KA; Holmes, DA; Kitchen, C.M.R.; Linde, A; Dahl, H; Dwyer, D

    1997-01-01

    The clinical efficacy and safety of sorivudine as treatment for acute cutaneous tester in human immunodeficiency virus-infected adults was compared with that of acyclovir in a double-blinded randomized study, A total of 125 patients with laboratory-confirmed tester rash present for less than or equa

  4. Herpes Zoster and Postherpetic Neuralgia: Past, Present and Future

    Directory of Open Access Journals (Sweden)

    Gary J Bennett

    2009-01-01

    Full Text Available OBJECTIVES: The history behind the current understanding of the varicella-zoster virus and its relationship to the pain conditions caused by shingles and postherpetic neuralgia are reviewed. The framework for the current conceptualization is Hope-Simpson’s latency hypothesis. Data from recent work in virology, neuroanatomy and epidemiology are reviewed, as is work using varicella-zoster virus-infected animals. The recent data largely confirm Hope-Simpson’s hypothesis and extend it significantly.

  5. 针灸治疗带状疱疹的临床研究进展%Research Progress of Acupuncture in the Treatment of Herpes Zoster

    Institute of Scientific and Technical Information of China (English)

    张莉莉; 孙忠人; 仇立波

    2015-01-01

    带状疱疹是由水痘-带状疱疹病毒引起的急性感染性皮肤病,中医称之为“蛇丹”、“蜘蛛疮”、“火带疮”、“缠腰火丹”等,神经痛为本病特征之一。近年来,针灸治疗带状疱疹的经验越来越丰富,疗效明显优于西药,且副作用小。现将临床上针灸治疗带状疱疹的方法做一总结,为治疗此病选择更有效的方法提供参考。%Herpes zoster is an acute infectious skin disease caused by the varicella zoster virus.In traditional Chinese medicine it is called“Snake Dan”,“Spider chuang”,“Huo Dai Chuang”,“Chan Yao Huo Dan”and so on.Nerve pain is one of the characteristics.In recent years, the experience of acupuncture treatment for her-pes zoster has been becoming richer and richer.The therapeutic effect is better than western medicine.What’ s more,acupuncture has lower side effects.This article makes a summary of using acupuncture in the treatment of herpes zoster to provide a more effective method for treating herpes zoster.

  6. The short- and long-term risk of stroke after herpes zoster - a nationwide population-based cohort study.

    Directory of Open Access Journals (Sweden)

    Nandini Sreenivasan

    Full Text Available BACKGROUND AND OBJECTIVE: Varicella zoster virus (VZV is known to cause VZV vasculopathy, which may be associated with stroke. A recent study found an increased risk of stroke within one year of herpes zoster. We aimed to investigate the short and long-term effects of herpes zoster on the risk of stroke. METHODS: Using Danish national registers, we constructed a cohort consisting of all Danish adults ≥18 years old between 1995 and 2008 (n = 4.6 million; person-years of follow-up = 52.9 million. Individual-level information on prescriptions for herpes zoster antiviral treatment and diagnoses of stroke was obtained from national registers. We compared the risk of stroke in persons who had received the specific dosage of acyclovir for herpes zoster with persons who had never received antiviral treatment by Poisson regression. RESULTS: During follow-up, 2.5% received treatment for herpes zoster and 5.0% were diagnosed with stroke. Individuals who had received medication had a 127% (95% CI 83-182% increased risk the first two weeks, 17% (CI 9-24% between two weeks and one year, and 5% (2-9% after the first year. The increased risk was greatest in the youngest age group (<40. To control for healthcare-seeking behaviour, we conducted parallel analyses investigating the risk of selected fractures after herpes zoster and found no similar increased risks. CONCLUSIONS: This large nationwide cohort study found an increased risk of stroke after treatment for herpes zoster. Although the short-term risk was particularly high, we cannot rule out the possibility of a small but important long-term risk.

  7. Efficacy observation on treating 32 cases of herpes zoster with the fire needle therapy%火针疗法治疗带状疱疹32例疗效观察

    Institute of Scientific and Technical Information of China (English)

    谢祖艺; 杨作卿; 曾庆萍; 鲁莉燕; 黄伟福

    2013-01-01

    带状疱疹是一种急性疱疹性皮肤病。西医暂无特效疗法,火针疗法治疗带状疱疹简单、实用、疗效好、易操作。采用火针疗法治疗32例带状疱疹,临床疗效满意,值得推广。%Herpes zoster is an acute skin disease. Little effects in modern medicine therapy, fire needle therapy for herpes zoster is simple, practical, effective, and easy to operate. Using fire needle therapy to treat 32 cases of herpes zoster, the clinical results are satisfactory, worthy of promotion.

  8. Experimental studies on the prevention and treatment of chickenpox and herpes zoster with measles vaccine.

    Science.gov (United States)

    Li, W H; Ming, Z L; Chen, Q; Li, Y

    1989-05-01

    In 151 chickenpox patients treated with live attenuated measles vaccine, the cure rate was 100%. In 145 cases of herpes zoster, the effective rate was 100% (completely cured in 91.7% and improved in 8.3%). In the treated group, the time needed for the subsidence of fever and skin rash and the duration of the disease were markedly shorter than those in the control group (P less than 0.01). It is particularly effective for alleviating pain, preventing and relieving postherpetic neuralgia in patients with zoster. The application of measles vaccine to the patients in the chickenpox incubation period might prevent the development of the disease, and decrease the incidence and death rate of varicella zoster virus infection in highly susceptible patients. The mechanism of its anti-viral action and production of interferon in the body is discussed.

  9. Comparative efficacy of phenytoin, steroid and carbamazepine in herpes zoster and post herpetic neuralgia

    Directory of Open Access Journals (Sweden)

    Agarwal S

    1991-01-01

    Full Text Available Three hundred patients of different ages were sequentially assigned three therapy groups (100 in each group viz. phenytoin, steroid (prednisolone and carbamazepine. Effect of these drugs on herpes zoster neuralgia and in prevention of post herpetic neuralgia was studied. Phenytoin was found to be superior to both steroid and carbamazepine in relieving the pain of herpes zoster and in reducing the incidence of post herpetic neuralgia. Only 16.1% of the patients in phenytoin treated group developed post herpetic neuralgia lasting for 2-4 weeks while 22.7% and 29.6% of the steroid and carbamazepine treated patients respectively developed post herpetic neuralgia and that too lasting for longer duration. No patient under 40 years developed post herpetic neuralgia.

  10. The diagnosis and treatment of herpes zoster%带状疱疹的诊治

    Institute of Scientific and Technical Information of China (English)

    张先雷; 孟胜利

    2016-01-01

    带状疱疹,又名盘腰缠,其发病率较高,有些患者症状不典型,确诊有一定的难度,给患者的后续诊治造成困难。本文简要介绍带状疱疹的诊治,为临床提供探讨。%Herpes zoster is the scientiifc name for Pan Yao Chan.Its incidence rate is high.The symptoms of some patients are not typical.Diagnosis has certain dififculty,which causes dififculties in the follow up diagnosis and treatment of patients.In this article,the author briefly introduces the diagnosis and treatment of herpes zoster,to provide discuss for clinic.

  11. The effect and mechanism analysis of valaciclovir on herpes zoster in elderly patients

    Institute of Scientific and Technical Information of China (English)

    Yu-Hua Chen

    2015-01-01

    Objective: To explore the effect and mechanism of valaciclovir on herpes zoster in elderly patients. Methods: 80 cases patients received valaciclovir treatments in our hospital were analyzed in this part. The expression of TNF-α, NF-κB, CD4 and CD8 were detected by Western Blotting. Results: The content of TNF-α, NF-κB, CD4 and CD8 was increased greatly in patients after drug treatments with statistical differences. Conclusion: Up-regulated expression of TNF-α, NF-κB, CD4 and CD8 is involved in the pathogenesis of herpes zoster and valaciclovir therapy mainly through normalizing those abnormal expressions of proteins.

  12. Herpes Zoster oftálmico e posterior acidente vascular cerebral: relato de caso

    Directory of Open Access Journals (Sweden)

    Carlos A. M. Guerreiro

    1984-12-01

    Full Text Available Um caso de acidente vascular cerebral (AVC 14 semanas após a instalação de herpes zoster oftálmico (HZO é apresentado. A tomografia computadorizada craniana documentou comprometimento em território de artéria cerebral média ipsilateral ao HZO. O diagnóstico de probabilidade é o de arterite por herpes zoster com posterior trombose. Os autores reviram a literatura e enfatizam o longo intervalo entre o HZO e a instalação da hemiplegia. Citam as novas drogas antivirais que tornam esta causa de AVC potencialmente passível de ser prevenida.

  13. Herpes zoster as a marker of occult cancer

    DEFF Research Database (Denmark)

    Schmidt, S A J; Mor, A; Schønheyder, H C;

    2016-01-01

    : Through February 18, 2016, we searched PubMed, EMBASE and references of relevant papers for studies on zoster and risk of any cancer. One author screened retrieved papers by title and abstract; included papers were reviewed by two authors for eligibility, data extraction, and potential biases. Despite...

  14. Herpes zoster and the risk of ischemic and hemorrhagic stroke: A systematic review and meta-analysis

    Science.gov (United States)

    Tang, Fang; Yang, Bing; Duan, Ruisheng

    2017-01-01

    Background Herpes zoster infection and stroke are highly prevalent in the general population; however, reports have presented inconsistent findings regarding the relationship between herpes zoster infection and stroke. In this meta-analysis, we aimed to clarify this association. Material and methods The PubMed and Embase databases were searched for studies published from their inception to January 2016. Two investigators independently extracted the data. The pooled relative risk (RR) was calculated using a random effects model. Results A total of 8 studies met the inclusion criteria. During the first 1 month after herpes zoster infection, the pooled RRs for ischemic stroke and hemorrhagic stroke were 1.55 (95% CI, 1.46–1.65) and 1.70 (95% CI, 0.73–3.96), respectively, and within 3 months after infection, the corresponding RRs were 1.17 (95% CI, 1.12–1.23) and 2.05 (95% CI, 1.17–3.60), respectively. At 1 year and more than 1 year after herpes zoster infection, a significant relationship was not observed between herpes zoster infection and the incidence of ischemic and hemorrhagic stroke. Publication bias was not observed. Conclusion The accumulated evidence generated from this systematic review indicates that an increased risk for ischemic stroke occurred in the short term after herpes zoster infection, whereas a significant relationship was not observed in the long term after infection. With respect to hemorrhagic stroke, the association was not significant. With respect to hemorrhagic stroke, the association between was not significant except within 3 months after a herpes zoster infection. PMID:28178287

  15. Varicella and herpes zoster vaccines: WHO position paper, June 2014--Recommendations.

    Science.gov (United States)

    2016-01-04

    This article presents the World Health Organization's (WHO) recommendations for the use of varicella and herpes zoster vaccination from the WHO position paper on varicella and herpes zoster vaccines - June 2014, published in the Weekly Epidemiological Record [1]. This position paper summarizes the WHO position on the use of varicella and herpes zoster vaccines. The current document replaces the position paper on the use of varicella vaccines published in 1998 [2]. Footnotes to this paper provide a number of core references. In accordance with its mandate to provide guidance to Member States on health policy matters, WHO issues a series of regularly updated position papers on vaccines and combinations of vaccines against diseases that have an international public health impact. These papers are concerned primarily with the use of vaccines in large-scale immunization programmes; they summarize essential background information on diseases and vaccines, and conclude with WHO's current position on the use of vaccines in the global context. This paper reflects the recommendations of WHO's Strategic Advisory Group of Experts (SAGE) on immunization. These recommendations were discussed by SAGE at its April 2014 meeting. Evidence presented at the meeting can be accessed at http://www.who.int/immunization/sage/previous/en/index.html.

  16. A COMPARATIVE STUDY TO EVALUATE THE EFFICACY AND SAFETY OF VALACYCLOVIR AND FAMCYCLOVIR IN THE MANAGEMENT OF HERPES ZOSTER IN A TERTIARY CARE HOSPITAL IN PUDUCHERRY

    Directory of Open Access Journals (Sweden)

    Indradev

    2014-05-01

    Full Text Available OBJECTIVE: The objective of this study was to compare the efficacy and safety of Valacyclovir and Famcyclovir in the management of Acute Herpes Zoster. MATERIALS AND METHODS: Relevant data were taken from 162 patients with herpes zoster who presented within 72 hours of onset of rash and were randomized into 2 groups of 81 each. The 1st group received Valacyclovir 1gm thrice a day for 7 days while those in the 2nd group received Famcyclovir 500 mg thrice a day for 7 days respectively and evaluated at the end of each week upto 6 weeks period and examined for full crusting of lesions, complete healing of the lesion and loss of acute pain (visual analogue scale scores for pain. Safety assessment was based on adverse effects. RESULTS: The intent to treat analysis (162 Pts showed that valacyclovir for 7 days significantly accelerated the resolution of pain in Herpes zoster pts (P=0.00014 compared with famcyclovir; median pain duration were 21 and 22 days respectively. There was no difference between treatments in time taken for healing of lesions. Adverse effects like nausea, vomiting, diarrhoea and headache were commonly reported in both groups. Valacyclovir was found to be statistically superior over Famcyclovir in terms of G.I adverse effects. Compliance was also better with Valacyclovir. CONCLUSION: Oral Valacyclovir administered three times daily for 7 days during acute zoster infection offers significant benefit by providing a well-tolerated, cost effective and accelerated rate of resolution of pain and maintains the favorable safety profile compared to oral Famcyclovir.

  17. Longitudinal risk of herpes zoster in patients with non-Hodgkin lymphoma receiving chemotherapy: A nationwide population-based study.

    Science.gov (United States)

    Cho, Shih-Feng; Wu, Wan-Hsuan; Yang, Yi-Hsin; Liu, Yi-Chang; Hsiao, Hui-Hua; Chang, Chao-Sung

    2015-09-22

    This study investigated the incidence of and risk factors for herpes zoster in patients with non-Hodgkin lymphoma (NHL) who were receiving anti-lymphoma treatment. The overall incidence density of herpes zoster was 12.21% (472/3865); 11.79% (258/2188) of the patients received conventional chemotherapy and 12.76% (214/1677) of the patients received rituximab-containing chemotherapy. For the patients who received conventional chemotherapy, the risk factors included female gender, multiple courses of chemotherapy and autologous hematopoietic stem cell transplantation. For the patients who received rituximab-containing chemotherapy, the risk factors included female gender, diabetes mellitus, multiple courses of chemotherapy, autologous hematopoietic stem cell transplantation and higher accumulated rituximab dose. The majority of the herpes zoster episodes occurred within the first two years after the diagnosis of NHL. After adjusting for the propensity score matching, rituximab-containing chemotherapy was not associated with a higher overall incidence density of herpes zoster (P = 0.155). However, the addition of rituximab to conventional chemotherapy increased the short-term risk of herpes zoster with adjusted odd ratios of 1.38 (95% confidence intervals (CI) = 1.05-1.81, P = 0.021) and 1.37 (95% CI = 1.08-1.73, P = 0.010) during the 1-year and 2-year follow-up periods, respectively.

  18. 浅谈肝郁与带状疱疹%Brief analysis on liver depression and herpes zoster

    Institute of Scientific and Technical Information of China (English)

    龙雄初; 龙枚飞; 李晓玲; 赵社海; 马洪仕

    2012-01-01

    通过对带状疱疹多年的诊治,结合目前该病的发病特点,从肝郁与人体正气(免疫力)、肝郁与带状疱疹的发病两个方面分析,结合现代医学探讨肝郁与带状疱疹的关系.笔者认为长时间的肝郁损伤人体正气,带状疱疹正是由于机体正气不足,免疫力下降,病毒被激活、繁殖而发病.肝郁是带状疱疹发病的重要因素.%According to years of treatment experience on herpes zoster,combined with its current onset characteristics as well as modem medicine,the authors probed into the relation between liver depression and herpes zoster on the following two aspects:one was liver depression and healthy qi (immunity) ; the other was liver depression and the incidence of herpes zoster.We considered that long-term liver depression impairs healthy qi.Then herpes zoster appears because detriment of healthy qi leading to decreased immunity,reactivation and reproduction of virus.Liver depression is a significant factor for the onset of herpes zoster.

  19. Herpes zoster em pacientes com lúpus eritematoso sistêmico juvenil Herpes zoster in patients with juvenile systemic lupus erythematosus

    Directory of Open Access Journals (Sweden)

    Paula da Silva Neves

    2007-04-01

    Full Text Available Infecção pelo vírus varicela zoster (VVZ em pacientes com lúpus eritematoso sistêmico juvenil (LESJ tem sido pouco descrita. Durante um período de 12 anos, ocorreram 195 internações em 77 pacientes com LESJ e estas foram acompanhadas pela Unidade de Reumatologia Pediátrica do Instituto da Criança do Hospital das Clínicas da Universidade de São Paulo. Onze pacientes (14%, dez do sexo feminino, apresentaram 14 internações (7,1% pelo VVZ. Nesses pacientes, a média de idade foi de 16 anos e 5 meses e a média do tempo de duração do LESJ até a primeira infecção devido ao VVZ foi de 4 anos. Todos os episódios das infecções estavam associados com atividade da doença, que se apresentaram como lesões vesicobolhosas seguindo trajeto nervoso. As regiões do tórax e membros foram mais comumente afetadas. Todos haviam utilizado prednisona e quatro usaram ciclofosfamida EV. Todos receberam aciclovir EV por 7 a 10 dias. Nenhum paciente apresentou neuralgia pós-herpética, infecção bacteriana secundária ou evoluiu para óbito. Entretanto, uma paciente em uso de aciclovir apresentou amaurose aguda por vasculite necrosante retiniana bilateral associado ao VVZ, necessitando de duas aplicações de ganciclovir intravítreo e gamaglobulina EV (2 g/kg/dose, com recuperação parcial da acuidade visual. Assim sendo, infecção por VVZ em pacientes com LESJ foi infreqüente, habitualmente associada à atividade da doença e à corticoterapia. Essa infecção foi controlada com aciclovir, e os pacientes raramente apresentaram complicações.Varicella zoster virus (VZV infection in patients with juvenile systemic lupus erythematosus (JSLE has been rarely described. 195 hospitalizations of 77 JSLE patients occurred in a period of 12 years and were followed at the Pediatric Rheumatology Unity of the Instituto da Criança - Hospital das Clínicas - Universidade de São Paulo. Eleven patients (14%, 10 female, had 14 hospitalizations (7.1% due to

  20. Association of cigarette smoking with a past history and incidence of herpes zoster in the general Japanese population: the SHEZ Study.

    Science.gov (United States)

    Ban, J; Takao, Y; Okuno, Y; Mori, Y; Asada, H; Yamanishi, K; Iso, H

    2017-01-16

    Few studies have examined the impact of cigarette smoking on the risk for herpes zoster. The Shozu Herpes Zoster (SHEZ) Study is a community-based prospective cohort study over 3 years in Japan aiming to clarify the incidence and predictive and immunological factors for herpes zoster. We investigated the associations of smoking status with past history and incidence of herpes zoster. A total of 12 351 participants provided valid information on smoking status and past history of herpes zoster at baseline survey. Smoking status was classified into three categories (current, former, never smoker), and if currently smoking, the number of cigarettes consumed per day was recorded. The participants were under the active surveillance for first-ever incident herpes zoster for 3 years. We used a logistic regression model for the cross-sectional study on the association between smoking status and past history of herpes zoster, and a Cox proportional hazards regression model for the cohort study on the association with risk of incidence. The multivariable adjusted odd ratios (95% CI) of past history of herpes zoster for current vs. never smokers were 0·67 (0·54-0·80) for total subjects, 0·72 (0·56-0·93) for men and 0·65 (0·44-0·96) for women. The multivariable adjusted hazard ratios (95% CI) of incident herpes zoster for current vs. never smokers were 0·52 (0·33-0·81) for total subjects, 0·49 (0·29-0·83) for men and 0·52 (0·19-1·39) for women. Smoking status was inversely associated with the prevalence and incidence of herpes zoster in the general population of men and women aged ⩾50 years.

  1. Vaccination against herpes zoster in developed countries: state of the evidence.

    Science.gov (United States)

    Drolet, Mélanie; Oxman, Michael N; Levin, Myron J; Schmader, Kenneth E; Johnson, Robert W; Patrick, David; Mansi, James A; Brisson, Marc

    2013-05-01

    Although progress has been made in the treatment of herpes zoster (HZ) and postherpetic neuralgia (PHN), available therapeutic options are only partially effective. Given evidence that a live-attenuated varicella-zoster-virus vaccine is effective at reducing the incidence of HZ, PHN and the burden of illness, policymakers and clinicians are being asked to make recommendations regarding the use of the zoster vaccine. In this report, we summarize the evidence regarding the: (1) burden of illness; (2) vaccine efficacy and safety; and (3) cost-effectiveness of vaccination, to assist evidence-based policy making and guide clinicians in their recommendations. First, there is general agreement that the overall burden of illness associated with HZ and PHN is substantial. Second, the safety and efficacy of the zoster vaccine at reducing the burden of illness due to HZ and the incidence of PHN have been clearly demonstrated in large placebo-controlled trials. However, uncertainty remains about the vaccine's duration of protection. Third, vaccination against HZ is likely to be cost-effective when the vaccine is given at approximately 65 y of age, if vaccine duration is longer than 10 y.

  2. 带状疱疹急性期临床症状与皮损区病理性改变的相关性研究%Study on relationship between clinical symptoms and pathological changes in skin lesions of patients with herpes zoster in acute phase

    Institute of Scientific and Technical Information of China (English)

    高月; 季凤清; 李彦平; 孙海梅; 张乐辉

    2013-01-01

    Objective To observe the relationship between clinical symptoms and pathological changes in skin lesions of patients with herpes zoster in acute phase, and the effect of early application of anti - inflammatory and immune therapy for skin lesions on the course of disease. Methods There were two stages in this study. In the first stage, skin tissues under herpes or in pain locations of 3 patients with definite diagnosis of herpes zoster were taken and prepared for conventional slices with HE staining and S -100 staining. Abnormal lymphocytes infiltration and nerve ending lesions in these sections were observed. In the second stage, 36 patients with herpes zoster in acute phase were randomly assigned to two groups. Patients in nerve block group ( n = 18 ) receiving subcutaneous block by injection of solution ( 10 ~ 15 ml in volume ) containing 0.3% li-docaine, 0. 5mg cobamamide and 40 mg methylprednisolone into skin where the most severe skin lesions or the most intense pain occurred from proximal to distal part according to the nerve distribution. Patients in medicine group ( n = 18 ) receiving conventional therapy by taking oral antiviral agents, vitamin B12, analgesics, and applying topical agents in skin lesions. The difference in duration of healing of skin lesions and reduction of pain intensity in the acute phase between these two different therapeutic methods was observed. Results Epidermal atrophy and partial basal cells liquidation were found in skin lesions. A moderate number of lymphoidocytes and plasmocytes were peripherally infiltrated the dO ermis and blood vessels. Mild edema was found in the superficial layer of dermis. Injured peripheral nerve, damaged axons, and infiltration of a small number of lymphocytes were observed in immunohistochemical staining sections. Patients with the same skin lesions had shorter time for incrustation in nerve block group than that of medicine group ( P 〈 0.05 ). Pain intensity of patients in nerve block group was

  3. MRI diagnosis of muscle denervation from herpes zoster with discordant distribution of the skin rash

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, Amit; Sundaram, Murali [Cleveland Clinic, Section of Musculoskeletal Radiology, Imaging Institute, Cleveland, OH (United States); Winalski, Carl S. [Cleveland Clinic, Section of Musculoskeletal Radiology, Imaging Institute, Cleveland, OH (United States); Cleveland Clinic, Department of Biomedical Engineering, Lerner Research Institute, Cleveland, OH (United States)

    2014-10-15

    Herpes zoster is a common disorder characterized by a painful rash along a dermatome caused by reactivation of the varicella zoster virus (VZV). Muscle denervation injury from motor involvement is an uncommon phenomenon. Discordant distribution of the skin rash and motor nerve involvement, presenting as a skin rash in one body part and muscle weakness or pain from nerve involvement in another body part is an even more uncommonly reported finding. We present an unusual case of muscle denervation injury resulting from motor involvement of a peripheral nerve by VZV diagnosed by magnetic resonance imaging with cutaneous manifestations in a different dermatomal distribution. To the best of our knowledge, there has been no similar case reported in the English radiology literature. We suggest that whenever a radiologist notices MRI findings suggesting denervation injury and a cause not readily identified, VZV-related denervation injury should be included in the differential diagnosis, especially in an older immunocompromised patient. (orig.)

  4. [Case of spinal epidural abscess after continuous epidural block to manage the pain of herpes zoster].

    Science.gov (United States)

    Miyamoto, Tatsuhito; Nakatani, Toshihiko; Narai, Yasuhiro; Sakakibara, Manabu; Hashimoto, Tatsuya; Saito, Youji

    2014-03-01

    A woman in her 90's received continuous epidural block for the pain of herpes zoster. Four days after epidural catheterization, she was found with cellutitis. Fourteen days after epidural catheterization, spinal epidural abscess was pointed out on MRI. Since there were no neurological symptoms, we performed conservative medical management with antibiotics. She recovered without sequela When the symptoms of cellutitis appeared after epidural block (even if there are neither neurological symptoms nor infectious signs), there is a possibility of progressing into spinal epidural abscess.

  5. Herpes Zoster with Post Herpetic Neuralgia Involving the Right Maxillary Branch of Trigeminal Nerve: A Case Report and Review of Literature

    Science.gov (United States)

    Subramanian, Kailasam; Sankari, S Leena; Potluri, Venkata Lakshmi Aparna; Prabakaran, Akila

    2017-01-01

    Herpes Zoster (HZ) is an acute, self-limiting, neuro cutaneous viral infection caused by the reactivation of the Varicella Zoster Virus (VZV) that remains latent in the dorsal root ganglion. About 50% of occurrence is seen in older age groups and immunocompromised patients. Less than 5% occur in children. HZ is characterized by the unilateral pain, burning and tingling sensation followed by the vesicular eruptions limited to the single dermatome that are innervated by the single cranial ganglion, sometimes it leads to Post Herpetic Neuralgia (PHN). We report a case of a HZ in a 22-year-old young female patient involving the right maxillary branch of the trigeminal nerve along with PHN. PMID:28274075

  6. Burden of herpes zoster and postherpetic neuralgia in Japanese adults 60 years of age or older: Results from an observational, prospective, physician practice-based cohort study.

    Science.gov (United States)

    Sato, Keiko; Adachi, Koichi; Nakamura, Hiroyuki; Asano, Kazuhiro; Watanabe, Akihiro; Adachi, Riri; Kiuchi, Mariko; Kobayashi, Keiju; Matsuki, Taizo; Kaise, Toshihiko; Gopala, Kusuma; Holl, Katsiaryna

    2016-12-05

    Approximately one in three persons will develop herpes zoster during their lifetime, and it can lead to serious complications such as postherpetic neuralgia. However, evidence on burden of herpes zoster and postherpetic neuralgia in Japan is limited. This prospective, observational, multicenter, physician practice-based cohort study was conducted in Kushiro, Hokkaido, Japan (Clinicaltrials.gov identifier NCT01873365) to assess the incidence and hospitalization rates of herpes zoster, and the proportion, clinical burden and risk factors for postherpetic neuralgia in adults aged 60 years or more. Within the study area, 800 subjects developed herpes zoster and 412 were eligible for the study. Herpes zoster incidence was 10.2/1000 person-years and higher among women and older subjects. Subjects with herpes zoster required on average 5.7 outpatient consultations. Herpes zoster-associated hospitalization rate was 3.4% (27/800). The proportion of postherpetic neuralgia and other complications was 9.2% (38/412) and 26.5% (109/412), respectively. Statistically significant association with the development of postherpetic neuralgia was male sex (odds ratio [OR], 2.51; 95% confidence interval [CI], 1.17-5.38), age of 70-74 years (OR, 3.51; 95% CI, 1.09-11.3), immunosuppressive therapy (OR, 6.44; 95% CI, 1.26-32.9), severe herpes zoster pain at first consultation (OR, 3.08; 95% CI, 1.10-8.62) and rash on upper arms (vs no rash on upper arms; OR, 3.46; 95% CI, 1.10-10.9). Considerable herpes zoster and postherpetic neuralgia burden exists among elderly in Japan, and there may be predictive factors at the first visit which could be indicative of the risk of developing postherpetic neuralgia.

  7. Study on the clinical efficacy of transversal abdominal plane blockade in treatment of acute herpes zoster on abdomen%腹横肌平面阻滞治疗腹部急性带状疱疹的临床观察

    Institute of Scientific and Technical Information of China (English)

    刘永彬; 万磊; 罗克金

    2016-01-01

    目的:观察腹横肌平面阻滞治疗急性期下腹部带状疱疹的临床疗效。方法28例急性带状疱疹患者随机分为肋间神经阻滞组(IC 组,n =14)和腹横肌平面阻滞组(TP 组,n =14),分别接受 T10、T11、T12椎旁肋间神经阻滞(1次/周,共4次)和患侧腹横肌平面阻滞(1次/周,共4次)。观察两组的阻滞平面范围评分值、结痂时间、4周后通常痛视觉模拟评分和爆发痛视觉模拟评分。结果 TP 组阻滞平面评分值明显高于 IC 组( P <0.05)。TP 组皮肤结痂时间明显短于 IC 组( P <0.05)。TP 组疼痛视觉模拟评分值明显低于 IC 组( P <0.05)。结论腹横肌平面阻滞可以有效控制急性期下腹部带状疱疹所致皮神经疼痛,同时有助于带状疱疹皮损区的愈合。%Objective To observe the efficacy of transversal abdominal plane blockade in treatment of patients with acute herpes zoster in lower abdomen. Methods Twenty - eight patients with acute herpes zoster in lower abdomen were randomly assigned into group IC(n = 14),pa-tients in this group received paravertebral intercostal nerve blockade at T10 ,T11 and T12(once a week and four times as one course)and patients in group TP( n = 14)received transversal abdominal plane blockade( once a week and four times as one course). Scales of blockade level (SBL),time for forming scab(TFB),visual analogue scales(VAS)of common pain and visual analogue scales(VAS)of burst pain after four weeks were observed and recorded. Results Scales of blockade level(SBL)in group TP were higher than those of group IC( P < 0. 05). The duration for forming scab in patients of group TP was shorter than that of patients in group IC( P < 0. 05). Visual analogue scales(VAS)of com-mon pain and burst pain in patients of group TP were lower than those of patients in group IC( P < 0. 05). Conclusion Transversal abdominal plane blockade is effective in alleviating cutaneous nerve pain

  8. Dental complications of herpes zoster: Two case reports and review of literature

    Directory of Open Access Journals (Sweden)

    Swati Gupta

    2015-01-01

    Full Text Available Herpes zoster (HZ (shingles results due to reactivation of varicella-zoster virus. Unusual dental complications like osteonecrosis, exfoliation of teeth, periodontitis, and calcified and devitalized pulps, periapical lesions, and resorption of roots as well as developmental anomalies such as irregular short roots and missing teeth may arise secondary to involvement of 2 nd or 3 rd division of trigeminal nerve by HZ. Such cases pose both a diagnostic as well as a therapeutic challenge. We report two such rare dental complications of HZ-spontaneous tooth exfoliation and osteonecrosis of the maxilla in a 70-year-old female patient; and multiple periapical pathoses affecting right half of the mandibular teeth in a 45-year-old female patient. Both the patients did not have any associated systemic illness. The aim of this paper was to compare the present cases with all the 46 cases of osteonecrosis and 6 cases of multiple periapical pathoses secondary to trigeminal zoster reported in literature till date The article also throws light that the occurrence of such dental complications of HZ is not entirely dependent on the immune status of the host.

  9. Distribution of health effects and cost-effectiveness of varicella vaccination are shaped by the impact on Herpes Zoster.

    NARCIS (Netherlands)

    Lier, A. van; Lugner, A.K.; Opstelten, W.; Jochemsen, P.; Wallinga, J.; Schellevis, F.; Sanders, E.; Melker, H. de; Boven, M. van

    2015-01-01

    Background: Herpes zoster (HZ) is a painful disease affecting a considerable part of the elderly. Programmatic HZ vaccination of elderly people may considerably reduce HZ morbidity and its related costs, but the extent of these effects is unknown. In this article, the potential effects and cost-effe

  10. 带状疱疹202例临床分析%Clinical analysis of 202 cases of herpes zoster

    Institute of Scientific and Technical Information of China (English)

    张源; 王青; 张腾

    2016-01-01

    目的:探究带状疱疹患者的临床特点及高危因素。方法:回顾性分析带状疱疹患者202例的临床资料。结果:73例患者发病年龄≥65岁。皮损位于肋间神经分布区域90例。误诊率12%。结论:带状疱疹在中老年人中发病率较高,最易累及肋间神经,心脑血管病是带状疱疹发病的高危因素。%Objective:To explore the clinical characteristics and high risk factors of patients with herpes zoster.Methods:The clinical data of 202 cases of patients with herpes zoster were analyzed retrospectively.Results:73 cases of patients were over 65 years old.90 cases had lesions in the distribution area of intercostal nerve.The misdiagnosis rate was 12%.Conclusion:Herpes zoster had higher incidence in the elderly and affected the intercostal nerve most easily,the cerebrovascular disease was high risk factors for the onset of herpes zoster.

  11. Detection of varicella-zoster virus and herpes simplex virus by the polymerase chain reaction with degenerate primers

    NARCIS (Netherlands)

    Jacobs, J.J.L.; Folkers, E.; Vreeswijk, J.

    1999-01-01

    Varicella-zoster virus (VZV) and herpes simplex virus (HSV) are human pathogens of significance involved in multiple diseases with either typical or atypical clinical features. In neonates and immunocompromised patients these alphaherpesviruses may cause life-threatening diseases such as encephaliti

  12. Longitudinal study on oral shedding of herpes simplex virus 1 and varicella-zoster virus in individuals infected with HIV

    NARCIS (Netherlands)

    M. van Velzen (Monique); W.J.D. Ouwendijk (Werner ); S. Selke (Stacy); S.D. Pas (Suzan); F.B. van Loenen (Freek); A.D.M.E. Osterhaus (Albert); A. Wald (Anna); G.M.G.M. Verjans (George)

    2013-01-01

    textabstractPrimary herpes simplex virus 1 (HSV-1) and varicella-zoster virus (VZV) infection leads to a life-long latent infection of ganglia innervating the oral mucosa. HSV-1 and VZV reactivation is more common in immunocompromised individuals and may result in viral shedding in saliva. We determ

  13. OBSERVATION ON THE THERAPEUTIC EFFECT OF PLUM-BLOSSOM NEEDLE TAPPING PLUS MEDICATION FOR HERPES ZOSTER

    Institute of Scientific and Technical Information of China (English)

    WANG Li-kang; YIN Li-li

    2005-01-01

    Objective: To observe the therapeutic effect of plum-blossom needle tapping combined with intravenous drip of Acyclovir for herpes zoster. Methods: A total of 40 herpes zoster patients were randomized into acupuncture plus medication group (n=21) and medication group (n=19) which were treated respectively with topical plum-blossom needle tapping in the focus region combined with intravenous drip of Acyclovir (250 mg+250 mL normal saline, twice daily) and simple intravenous drip of Acyclovir. Results: After treatment, of the 21 and 19 cases in acupuncture plus medication and medication groups, 18 (85.7%) and 10 (52.6%) were cured, 3 (14.3%) and 7 (36.8%) had marked improvement, 0 (0) and 2 (10.5%) failed, with the effective rates being 100.0% and 89.5% respectively. The cure duration of acupuncture plus medication and medication groups were (2.5±1.0) days and (4.0±2.3) days separately. The therapeutic effect of the former group was significantly superior to that of the later group (P<0.05) and the duration of cure of acupuncture plus medication group was evidently shorter than that of medication group (P<0.05). Conclusion: The therapeutic effect of plum-blossom needle tapping plus Acyclovir is significantly superior to that of simple Acyclovir in relieving pain, promoting scabbing, and shortening the therapeutic duration.

  14. Herpes zoster in psoriasis patients undergoing treatment with biological agents: prevalence, impact, and management challenges

    Directory of Open Access Journals (Sweden)

    el Hayderi L

    2016-10-01

    Full Text Available Lara el Hayderi, Fany Colson, Bita Dezfoulian, Arjen F Nikkels Department of Dermatology, CHU du Sart Tilman, University Hospital of Liège, Liège, Belgium Abstract: As TNF-α is a major factor in the immune defense against herpes zoster (HZ; an increased incidence and severity of HZ cases were suspected in patients undergoing treatment with TNF antagonists. Several studies and clinical experience provided evidence that the incidence of HZ increases by twofold to threefold in this patient category. The number of severe cases of HZ, with multisegmental, disseminated cutaneous, and/or systemic involvement, is also increased. Concerning psoriasis patients under biologicals, the clinician should be more alert for an eventual HZ event, in particular during the first year of biological treatment, and be aware of the possibility of more severe HZ cases. HZ may also undergo an age-shift toward younger patients. Rapid identification of risk factors for severe HZ, such as severe prodromal pains and/or the presence of satellite lesions, is recommended. The treatment recommendations of HZ in this patient group are identical to the recently published guidelines for the management of HZ. The live attenuated viral vaccine OKA/Merck strain anti-HZ vaccination is recommended before initiating biological treatment in psoriasis patients. The new adjuvanted anti-HZ vaccine will probably also benefit patients while on biological treatment. Keywords: herpes zoster, TNF antagonists, anti-IL17, anti-IL12/23, psoriasis, aciclovir

  15. The Evaluation Clinical and Demographic Characteristics of 115 Patients Diagnosed with Herpes Zoster in Eeastern Turkey

    Directory of Open Access Journals (Sweden)

    Hatice Uce Özkol

    2013-12-01

    Full Text Available Objective: The aim of this study was to investigate the clinical and demographic characteristics of patients diagnosed with herpes zoster and to explore the similarities and differences with other epidemiological studies from Turkey and the world. Methods: We retrospectively reviewed the records of 115 patients diagnosed with herpes zoster in the Yuzuncu Yıl University Medical Faculty Dermatology Department between January 2007 and December 2010. Results: The mean age of the patients was 42.21±23.88 years. 115 patients, -47 female (40.9%, 68 male (59.1%- aged between 2 and 93 years were assessed. Pediatric age group, 20 (17.4%, adult age group, 95 (82.6% patients, respectively. The incidence of HZ was found to be 0.43%. HZ was observed winter rarely (13.04%. Is mostly seen in the months of March (17.39% The affected dermatome were thorasic (49 patient, 42.6%, servical (21 patient, 18.3%, ophtalmic (22 patient, 19.1%, lomber (16 patient, 13.9%, sacral (7 patient, 6.1% respectively. Complications developed in 13% of patients. Conclusion: We observed that our findings were more or less similar to the findings of the literature data. Cases of HZ in our study was very rare during the winter season. Multi-center studies are needed to the emergence of clinical and epidemiological characteristics of HZ in Turkey.

  16. Vaccine-strain herpes zoster found in the trigeminal nerve area in a healthy child: A case report.

    Science.gov (United States)

    Iwasaki, Sayaka; Motokura, Kouji; Honda, Yoshitaka; Mikami, Masamitsu; Hata, Daisuke; Hata, Atsuko

    2016-12-01

    A previously healthy 2-year-old girl, vaccinated for varicella at 17 months, was admitted because of left-sided facial herpes zoster caused by vaccine-strain varicella-zoster virus (VZV). She recovered fully with no complication after intravenous treatment using acyclovir. Earlier reports have described that herpes zoster (HZ) rashes caused by vaccine-strain VZV tend to occur on the dermis corresponding to the skin area where the varicella vaccine was received. However, rashes appeared on this girl only in the trigeminal nerve area, which is unrelated to the vaccinated site. Results underscore the importance of distinguishing vaccine-strain VZV from wild-type VZV whenever encountering HZ cases after vaccination, even in immunocompetent children, irrespective of the skin lesion site. Monitoring vaccine-strain HZ incidence rates is expected to elucidate many aspects of varicella vaccine safety.

  17. The management of oral candidosis in diabetic patient with maxillary Herpes Zoster

    Directory of Open Access Journals (Sweden)

    Kus Harijanti

    2008-09-01

    Full Text Available Background: Oral candidosis is an infection caused by mainly Candida albicans. Candida species are common normal flora in the oral cavity and have been reported to be present in 40% to 60% of the population. Candida is predominantly an opportunistic infectious agent. Infection frequency has increased because of the presence of both local and systemic risk factors. The elderly age and diabetes mellitus may decrease the amount of saliva (xerostomia and potentially increase the risk of colonization and secondary infection by Candida. Herpes Zoster (HZ is a manifestation of the reactivation of latent varicella zoster virus. It is characterized by unilateral, painful, vesicular rash with a dermatomal distribution. The clinical manifestations of this disease can erupt to the skin and mucous membrane. If maxillary nerve is involved, the lesion can appear on unilateral facial skin and oral mucous membrane. Purpose: The purpose of this paper is to report and discuss the difficulties in managing the oral candidosis in elderly patient (57 year old male who suffered from maxillary Herpes Zoster and diabetes mellitus. Case management: At first, the patient was treated with 2% chlorhexidine gluconate and mycostatin oral suspension as topical antimycotic and reffered to dermathology clinic for viral infection treatment, however the oral candidosis did not improved. Subsequently, ketokonazole tablet was given three times daily for three weeks and regulated blood glucose level. In systemic antifungi (ketokonazole treatment the oral candidosis disappeared. Conclusion: In this case, it is conclude that the management of oral candidosis are adequate, antiviral, blood glucose level regulating and systemic antifungal therapy.

  18. 从1例带状疱疹性前庭神经元炎误诊引发的思考%Considerations on 1 cases of herpes zoster misdiagnosed

    Institute of Scientific and Technical Information of China (English)

    刘丽萍

    2014-01-01

    Herpes zoster is caused by the varicella-zoster virus invading peripheral nerves, which causes acute inflammatory skin disease,often encroachs intercostals nerve,and usually happens at the waist.It is rare that herpes zoster vestibular neuronitis occurs surrounding the pinna.In this paper, we will do a simple analysis for one misdiagnosed case of herpes zoster vestibular neuronitis,in the hope for the diagnosis and treatment of the disease in the clinical work.%带状疱疹是由水痘-带状疱疹病毒侵入周围神经后引起的急性炎性皮肤病,常侵犯肋间神经,好发于腰部。发生于耳郭周围的带状疱疹致前庭神经元炎者较少见。本文就1例带状疱疹性前庭神经元炎误诊病例做一简单分析,以期望在临床工作中针对该病的诊断以及治疗有所帮助。

  19. Current and future effects of varicella and herpes zoster vaccination in Germany - insights from a mathematical model in a country with universal varicella vaccination

    NARCIS (Netherlands)

    Horn, Johannes; Karch, André; Damm, Oliver; Kretzschmar, Mirjam; Siedler, Anette; Ultsch, Bernhard; Weidemann, Felix; Wichmann, Ole; Hengel, Hartmut; Greiner, Wolfgang; Mikolajczyk, Rafael T

    2016-01-01

    Varicella zoster virus (VZV) is primarily known for causing varicella in childhood, but can reactivate again as herpes zoster (HZ) after a period of latency, mainly in persons older than 50 years. Universal varicella vaccination was introduced in Germany in 2004, while HZ vaccination has not been re

  20. Evaluation of microRNA Expression in Patients with Herpes Zoster

    Directory of Open Access Journals (Sweden)

    Xihan Li

    2016-12-01

    Full Text Available Reactivated varicella-zoster virus (VZV, which lies latent in the dorsal root ganglions and cranial nerves before its reactivation, is capable of causing herpes zoster (HZ, but the specific mechanism of virus reactivation and latency remains unknown. It was proposed that circulating microRNAs (miRNAs in body fluids could potentially indicate infection. However, the connection between herpes zoster and circulating miRNAs has not been demonstrated. In this study, 41 HZ patients without superinfection were selected. The serum miRNA levels were analyzed by TaqMan low density array (TLDA and confirmed individually by quantitative reverse transcription PCR (RT-qPCR analysis. Thirty-five age-matched subjects without any infectious diseases or inflammation were selected as controls. The results showed that the serum miRNA expression profiles in 41 HZ patients were different from those of control subjects. Specifically, 18 miRNAs were up-regulated and 126 were down-regulated more than two-fold in HZ patients compared with controls. The subsequent confirmation of these results by qRT-PCR, as well as receiver operating characteristic (ROC curve analysis, revealed that six kinds of miRNAs, including miR-190b, miR-571, miR-1276, miR-1303, miR-943, and miR-661, exhibited statistically significant enhanced expression levels (more than four-fold in HZ patients, compared with those of healthy controls and herpes simplex virus (HSV patients. Subsequently, it is proposed that these circulating miRNAs are capable of regulating numerous pathways and some may even participate in the inflammatory response or nervous system activity. This study has initially demonstrated that the serum miRNA expression profiles in HZ patients were different from those of uninfected individuals. Additionally, these findings also suggest that six of the altered miRNA could be potentially used as biomarkers to test for latent HZ infection.

  1. 耳部无疱疹的带状疱疹性面瘫%Zoster sine herpete-Facial paralysis without herpes caused by herpes zoster virus

    Institute of Scientific and Technical Information of China (English)

    赵琨; 李健东; 赵亮; 于春刚; 李杨; 王杰

    2016-01-01

    疱疹顿挫型面瘫同亨特综合征一样,由水痘-带状疱疹病毒(varicella-zoster virus VZV)感染面神经所致,多为潜伏在膝状神经节的VZV病毒再次复活感染。表现为急性周围性面瘫,耳、舌、咽等部位的剧烈疼痛,伴有眩晕、听力下降等症状,但不出现疱疹,所以在临床中常常被误诊为贝尔面瘫。而其不论是病因、发病机制还是治疗及愈后方面与贝尔面瘫都不同,临床中常常耽误治疗,影响患者的愈后。本文就疱疹顿挫性面瘫在临床特征、发病机制、诊断、治疗及愈后等方面的进展做一综述,以引起耳鼻咽喉科医师对此类疾病的关注。%Zoster sine herpete (ZSH) facial palsy is caused by the varicella-zoster virus (VZV), similar to Ramsay Hunt syndrome. Latent VZV infection is reactivated in the geniculate ganglion, causing acute peripheral facial palsy, severe pain in the ear, tongue, pharynx and other regions of head and neck. Vertigo and hearing loss can be part of the process. However, facial palsies caused by VZV are not always accompanied by vesicular eruption, and these cases are referred to as zoster sine herpete (ZSH). Distinguishing ZSH from Bell palsy is difficult, and ZSH is often clinically diagnosed as Bell pal-sy. However, the etiology, pathogenesis, treatment and prognosis are quite different. So facial palsy in ZSH is often misdiag-nosed and adequate treatment delayed, leading to poor prognosis. In this paper, we elaborate on the clinical features, patho-genesis, diagnosis, treatment and prognosis of ZSH associated facial palsy, in order to bring it to the attention of Otorhinolar-yngologist.

  2. Coexistent granulomatous vasculitis and leukaemia cutis in a patient with resolving herpes zoster.

    Science.gov (United States)

    Elgoweini, M; Blessing, K; Jackson, R; Duthie, F; Burden, A D

    2011-10-01

    An 80-year-old man presented with a 6-month history of indurated tender purple papules. These had coalesced to form plaques with some central scarring and a dermatomal distribution on the left arm, immediately following herpes zoster (HZ) infection at this site. The patient had a 5-year history of small lymphocytic lymphoma (SLL), which was being managed conservatively under a 'watch and wait' protocol. On histological examination of a skin biopsy, marked interstitial granulomas and prominent granulomatous vasculitis were seen, supporting the clinical impression of a post-HZ granulomatous reaction. In addition, there was a dense monoclonal small B-cell lymphocytic infiltrate indicating koebnerization by SLL (a finding that has not been reported previously with concurrent postherpetic granulomatous vasculitis). Although benign pseudolymphomas occur in postherpetic cases, this case shows that even in association with benign vasculitic features true lymphomas can occur. Furthermore, this case highlights the importance of immunocytochemistry, molecular studies and clinicopathological correlation.

  3. The risk of herpes zoster during biological therapy for psoriasis and other inflammatory conditions.

    Science.gov (United States)

    Adelzadeh, L; Jourabchi, N; Wu, J J

    2014-07-01

    Recent advances in biological therapies have proved highly effective in treating psoriasis and other inflammatory conditions, including psoriatic arthritis, rheumatoid arthritis, inflammatory bowel disease and ankylosing spondylitis. However, adverse effects related to their immunosuppression have been observed, including an increased propensity to viral infections. This review evaluates the evidence of herpes zoster (HZ) risk from biologics based on clinical reports, cohort studies and randomized controlled studies. The risk of HZ associated with these agents remains controversial, especially when comparing their risk with non-biological therapy used to treat the same inflammatory conditions. This review specifically assesses the risk of the TNF inhibitors etanercept, adalimumab and infliximab, as well as interleukin-12/23 inhibitor ustekinumab. We found multiple cohort studies, randomized controlled trials and case reports that suggest infliximab increases risk of HZ, whereas adalimumab, etanercept and ustekinumab HZ risk remain controversial. Nevertheless, HZ vaccination should be considered prior to initiation of biological therapy, particularly infliximab.

  4. Preventing and managing herpes zoster: key actions to foster healthy aging.

    Science.gov (United States)

    Maggi, Stefania; Gabutti, Giovanni; Franco, Elisabetta; Bonanni, Paolo; Conversano, Michele; Ferro, Antonio; Lazzari, Marzia; Rossi, Alessandro; Scotti, Silvestro; Vitale, Francesco; Volpi, Antonio; Greco, Donato

    2015-02-01

    Population aging is the demographic phenomenon characterizing all countries in the world, and it is challenging the national infrastructures, in particular health systems. However, aging itself is not associated with increased medical spending, but disability and comorbidity that affect older individuals are the actual drivers for health expenditures. Therefore, if people age in better health, medical spending may be significantly reduced. Preventative interventions proved to be effective in reducing/preventing disease and disability and often found to be cost effective, include diet and exercise interventions, medications, routine disease screenings, and immunizations. Vaccination can protect older citizens against life-threatening diseases, such as influenza, pneumococcal infections, tetanus, and against diseases which adversely impact their quality of life, such as herpes zoster (HZ). Including HZ vaccination in its citizens' lifetime immunization calendar can reinforce Europe's commitment toward active, healthy aging. This paper outlines the consensus statement of a group of Italian experts on HZ.

  5. Herpes zoster in elderly adults in a community hospital in Buenos Aires. June 2013-May 2014

    Directory of Open Access Journals (Sweden)

    Miriam Rozenek

    2017-02-01

    Full Text Available Herpes zoster (HZ is caused by reactivation of the varicella zoster virus. Its main risk factor is increasing age and comorbidities. There are limited data on the characteristics of HZ in South America, especially in the elderly. We analyzed epidemiological and clinical characteristics of 340 patients over 60 years assisted for HZ, between June 2013 and May 2014. The average age was 74 years (60-100, 62% (210 had thoracic location; 75% (255 of the initial consultations were held in guards; 68% (143 had pain and vesicles, and 4% (14 only pain at baseline. Pain persisted after finishing the episode in 41% (139. The diagnosis was made between 1 and 3 days from the beginning of the episode in 53% (180 patients. Average number of visits per episode was 3.6 (1-24. Antiviral treatment was supplied to 91% (309; however it was inadequate in dose or time in 49.1% (167 cases. Pain treatment was indicated in 66% (224. Most frequently used drugs (alone or in combination were non-steroidal painkillers (43%, 146, pregabalin (30%, 102, opiates (24%, 82, and steroids (12%, 41; 9% (31 presented comorbidities; 27% (126 experienced pain after the ending of the episode, with an average duration of 138.7 days. In general, diagnosis was done late, making it difficult to use antivirals correctly. The presence of pain was more frequent than reported in other publications, however there are few data in this age group

  6. Advances in the understanding of the pathogenesis and epidemiology of herpes zoster

    Science.gov (United States)

    Gershon, Anne A.; Gershon, Michael D.; Breuer, Judith; Levin, Myron J.; Oaklander, Anne Louise; Griffiths, Paul D.

    2017-01-01

    SUMMARY The primary varicella zoster virus (VZV) infection results in chickenpox (varicella), which is transmitted via the airborne route. VZV is highly infectious, but in the USA the incidence of varicella has been reduced by 76–87% as a result of the varicella vaccine. The virus establishes latency in the dorsal root ganglia during varicella and, when reactivated, travels along the sensory nerve axons to cause shingles (herpes zoster [HZ]). There are over 1 million cases of HZ in the USA each year, with an estimated lifetime attack rate of 30%. The incidence of HZ, which causes significant morbidity, increases with age and reaches approximately 10 cases per 1,000 patient-years by age 80. Cell-mediated immunity (CMI) is known to decline with age as part of immunosenescence, and decreased CMI is associated with reactivation of VZV. This article provides an overview of our emerging understanding of the epidemiology and pathogenesis of varicella and HZ, in addition to exploring the current theories on latency and reactivation. Understanding the risk factors for developing HZ and the complications associated with infection, particularly in older people, is important for prompt diagnosis and management of HZ in primary care, and they are therefore also reviewed. PMID:20510263

  7. Genetic variation in the HLA region is associated with susceptibility to herpes zoster

    Science.gov (United States)

    Crosslin, D R; Carrell, D S; Burt, A; Kim, D S; Underwood, J G; Hanna, D S; Comstock, B A; Baldwin, E; de Andrade, M; Kullo, I J; Tromp, G; Kuivaniemi, H; Borthwick, K M; McCarty, C A; Peissig, P L; Doheny, K F; Pugh, E; Kho, A; Pacheco, J; Hayes, M G; Ritchie, M D; Verma, S S; Armstrong, G; Stallings, S; Denny, J C; Carroll, R J; Crawford, D C; Crane, P K; Mukherjee, S; Bottinger, E; Li, R; Keating, B; Mirel, D B; Carlson, C S; Harley, J B; Larson, E B; Jarvik, G P

    2015-01-01

    Herpes zoster, commonly referred to as shingles, is caused by the varicella zoster virus (VZV). VZV initially manifests as chicken pox, most commonly in childhood, can remain asymptomatically latent in nerve tissues for many years and often re-emerges as shingles. Although reactivation may be related to immune suppression, aging and female sex, most inter-individual variability in re-emergence risk has not been explained to date. We performed a genome-wide association analyses in 22 981 participants (2280 shingles cases) from the electronic Medical Records and Genomics Network. Using Cox survival and logistic regression, we identified a genomic region in the combined and European ancestry groups that has an age of onset effect reaching genome-wide significance (P>1.0 × 10−8). This region tags the non-coding gene HCP5 (HLA Complex P5) in the major histocompatibility complex. This gene is an endogenous retrovirus and likely influences viral activity through regulatory functions. Variants in this genetic region are known to be associated with delay in development of AIDS in people infected by HIV. Our study provides further suggestion that this region may have a critical role in viral suppression and could potentially harbor a clinically actionable variant for the shingles vaccine. PMID:25297839

  8. An update on the treatment and prevention of herpes zoster and postherpetic neuralgia%带状疱疹及其后遗神经痛治疗与预防

    Institute of Scientific and Technical Information of China (English)

    方丽; 吴贤杰

    2009-01-01

    带状疱疹及带状疱疹后遗神经痛是皮肤科引起神经性疼痛的常见原因,其治疗和预防是常见临床问题.抗病毒药物能够降低疱疹严重程度、缩短疱疹持续时间,但对带状疱疹后遗神经痛的作用尚不明确.糖皮质激素、三环类抗抑郁药、抗惊厥剂、镇痛药等均能减轻带状疱疹相关疼痛.抗惊厥剂、麻醉性镇痛药、三环类抗抑郁药及局部用利多卡因贴剂和辣椒素软膏均对带状疱疹后遗神经痛有效.接种水痘一带状疱疹疫苗对带状疱疹及带状疱疹后遗神经痛的发病率有重要影响.%Herpes zoster and postherpetic neuralgia(PHN)are common causes of neuropathic pain,their treatment and prevention ale usually troublesome.Antiviml drugs have been consistently found to effectively reduce the severity and duration of herpes zoster.However,there iS no convincing evidence that antiviral agents could reduce the risk of PHN.It is reported that the acute pain of herpes zoster can be relieved by corticosteroids,tricyclic antidepressants,anticonvulsants and analgesics,and PHN can be alleviated by anticonvulsants,narcotic analgesics.tricyclic antidepressants,lidocaine patch 5%and capsaicin ointment.Prophylactic vaccination with herpes zoster vaccine may have a beneficial effect on the incidence of herpes zosterand PHN.

  9. [Varicella and herpes zoster. Part 1: virology, epidemiology, clinical picture, laboratory diagnostics].

    Science.gov (United States)

    Wittek, Miriam; Doerr, Hans Wilhelm; Allwinn, Regina

    2010-05-01

    Varicella-zoster virus (VZV), known as one of the eight human herpesviridae, shows a ubiquitous distribution and is the cause for acute exanthema in childhood (chickenpox). VZV is highly infectious, spread by respiratory droplets and direct contact with fluid in vesicles. As a characteristic of the alpha-herpesviridae, VZV establishes latency in the nucleus of the paraspinal cells. Reactivation of VZV (zoster) is possible in all infected persons, but becomes more common with increasing age and a decline of VZV-specific cell-mediated immunity. Immunocompromised patients and older people (> 50 years) have an increased risk for a severe course of disease. The postherpetic neuralgia (PHN), as one of the most common and feared complications, is defined as a neuropathic pain (burning character), which persists for > 6 weeks after onset of disease and needs adequate antiviral and pain treatment.

  10. 带状疱疹89例临床分析%Clinical analysis of 89 patients with herpes zoster

    Institute of Scientific and Technical Information of China (English)

    徐勇梅

    2015-01-01

    Objective:To analyze the clinical characteristics of patients with herpes zoster. Methods:The retrospective studyof 89 patients withherpes zoster from Nov. 2013 to Oct. 2014 was conducted.Results:All patients received aciclovir and cobamamide. Among them, 66(74.16%) patients were cured in 2 to 8 weeks, and post-herpetic neuralgia was found in 6(6.74%) patients aged above 65 years. There were 32.58%(29/89) of the patients infected with virues of herpes zoster in winter.The herpes zoster was commonly seen in the chest of 32 patients(35.96%) and the patients over 50 years were susceptible to herpes zoster. Conclusion: The awareness of herpes zoster should be increased in patients as to early diagnosis and treatment.%目的:探讨带状疱疹的临床特点。方法:收集2013年11月至2014年10月门诊带状疱疹患者89例,回顾性分析患者的临床资料。结果:89例患者均采用阿昔洛韦联合腺苷钴胺治疗,其中66例(74.16%)在2~8周痊愈,后遗神经痛6例(6.74%),均为65岁以上患者。带状疱疹以冬季发病居多为32.58%(29/89),胸部发病最多见为35.96%(32/89),50岁以上患者较多占82.02%(73/89)。结论:应提高患者对带状疱疹的认知度,做到早就诊、早治疗。

  11. Clinical analysis of 616 herpes zoster cases%616例带状疱疹临床分析

    Institute of Scientific and Technical Information of China (English)

    王江涛

    2015-01-01

    目的:探讨带状疱疹的临床特点和发病规律,为带状疱疹的治疗提供参考依据。方法回顾性分析皮肤科门诊治疗的616例带状疱疹患者的临床资料。结果616例患者中,男370例,女246例,男性发病数是女性的1.5倍。带状疱疹发病时间以一、二季度较高,占401例(65.1%);发病年龄以中老年居多,占303例(49.2%)。结论带状疱疹患者中男性居多,发病率随年龄增大而增加,中老年患者病情重,容易导致后遗神经痛。早期规范治疗,可明显缩短病程及减少后遗神经痛的发生。%Objective To investigate clinical characteristics and occurrence regularity of herpes zoster, in order to provide reference for treating herpes zoster. Methods Clinical data of 616 herpes zoster patients in department of dermatology were retrospectively analyzed. Results Among 616 patients, there were 370 male and 246 female. Male had morbidity number as 1.5 times of female. The first and second quarters had higher occurrence of herpes zoster, accounting for 401 cases (65.1%). Middle-aged and elderly people accounted mostly as 303 cases (49.2%). Conclusion The majority of herpes zoster patients are male, and their morbidity increased with age. Middle-aged and elderly people had severe status, which can lead to postherpetic neuralgia. Early standard treatment can obviously shorten course of disease and reduce incidence of postherpetic neuralgia.

  12. The incidence of varicella and herpes zoster in Massachusetts as measured by the Behavioral Risk Factor Surveillance System (BRFSS during a period of increasing varicella vaccine coverage, 1998–2003

    Directory of Open Access Journals (Sweden)

    Clements Karen M

    2005-06-01

    Full Text Available Abstract Background The authors sought to monitor the impact of widespread varicella vaccination on the epidemiology of varicella and herpes zoster. While varicella incidence would be expected to decrease, mathematical models predict an initial increase in herpes zoster incidence if re-exposure to varicella protects against reactivation of the varicella zoster virus. Methods In 1998–2003, as varicella vaccine uptake increased, incidence of varicella and herpes zoster in Massachusetts was monitored using the random-digit-dial Behavioral Risk Factor Surveillance System. Results Between 1998 and 2003, varicella incidence declined from 16.5/1,000 to 3.5/1,000 (79% overall with ≥66% decreases for all age groups except adults (27% decrease. Age-standardized estimates of overall herpes zoster occurrence increased from 2.77/1,000 to 5.25/1,000 (90% in the period 1999–2003, and the trend in both crude and adjusted rates was highly significant (p Conclusion As varicella vaccine coverage in children increased, the incidence of varicella decreased and the occurrence of herpes zoster increased. If the observed increase in herpes zoster incidence is real, widespread vaccination of children is only one of several possible explanations. Further studies are needed to understand secular trends in herpes zoster before and after use of varicella vaccine in the United States and other countries.

  13. Survey on public awareness, attitudes, and barriers for herpes zoster vaccination in South Korea.

    Science.gov (United States)

    Yang, Tae Un; Cheong, Hee Jin; Song, Joon Young; Noh, Ji Yun; Kim, Woo Joo

    2015-01-01

    A cross-sectional study was performed to assess current public awareness of herpes zoster (HZ) and its vaccine, determine the factors that influence people's intention regarding HZ vaccination, and investigate the barriers for vaccination by changing decisions with sequential questions regarding knowledge, cost, and physician's recommendation in the Department of Infectious Diseases, Korea University Guro Hospital, in South Korea, between August 23 and September 15 of 2013. Among 603 subjects who completed the survey, 85.7% and 43.6% subjects were aware of HZ and HZ vaccination, respectively. Women, younger age group, those with higher income or higher education levels were more likely to be aware of HZ. Overall, 85.8% of subjects aware of HZ were willing to be vaccinated or vaccinate their parents. The main obstacles for the increased acceptance toward vaccination were the high cost and low perceived risk, which decreased acceptance to 60.2%. However, physician's recommendation reversed 69.5% of the refusal to accept HZ vaccine. These results indicate that expanding public education and physician's recommendations are important factors aimed at increasing HZ vaccine coverage rate.

  14. Benefit and Risk of Tofacitinib in the Treatment of Rheumatoid Arthritis: A Focus on Herpes Zoster.

    Science.gov (United States)

    Yamaoka, Kunihiro

    2016-09-01

    The biologics have revolutionized the treatment of rheumatoid arthritis (RA). However, there are still patients that are difficult to control and a cure is still not achievable. Tofacitinib, a Janus kinase (JAK) inhibitor is an orally available, new-in-class, disease-modifying anti-rheumatic drug with similar efficacy to biologics. JAK is activated by multiple cytokines involved in the pathology of RA, and affects non-immune and immune cells, mainly the lymphocytes. Besides its anti-rheumatic effect, the recent focus has been on adverse events. As with other biologics, serious infections have been observed especially with patients with lymphopenia, consistent with the mechanism of action. The major difference in adverse events from other disease-modifying anti-rheumatic drugs is the prominent increase in the occurrence of herpes zoster; it is increased worldwide, especially in Asia. There are other concerns such as malignancies and hyperlipidemia that may cause cardiovascular events that deserve further attention. The first JAK inhibitor for RA is demonstrating great benefit along with some risk, providing insights into the post-biologic era.

  15. Active herpes zoster infection with cutaneous manifestation and adenopathy on FDG PET/CT

    Directory of Open Access Journals (Sweden)

    Antoine Wadih, MD

    2015-10-01

    Full Text Available We report a patient with history of Hodgkin lymphoma. Six months after treatment, 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography and/or computed tomography ([18F] FDG PET/CT scan showed abnormal uptake in right axillary lymph nodes concerning for recurrence. In addition, PET/CT showed a new hypermetabolic skin lesion overlying the right scapula. Clinical evaluation was consistent with shingles, and the patient was treated with valacyclovir. Subsequent PET/CT scan was normal with no evidence of lymphoma. Although there have been reported cases of abnormal FDG in nodes or in skin due to herpes zoster, our case is unique in the literature in that the PET/CT demonstrates abnormalities involving both the skin and associated lymph nodes. The possibility of false positive uptake, not because of recurrent malignancy, must always be considered when abnormal FDG uptake is noted in the follow-up of oncology patients. Careful review of the scan and correlation with clinical findings can avoid false positive interpretation and facilitate patient management.

  16. Management and Prevention of Herpes Zoster in the Immunocompromised Inflammatory Bowel Disease Patient: A Clinical Quandary.

    Science.gov (United States)

    Côté-Daigneault, Justin; Peerani, Farhad; MacMahon, Eithne; Delaporte, Emmanuel; Rahier, Jean-François; Colombel, Jean-Frédéric

    2016-10-01

    Crohn's disease (CD) and ulcerative colitis (UC), the 2 main clinical phenotypes of inflammatory bowel disease (IBD), are diseases that result from a dysregulated immune response to gut microbiota in genetically susceptible hosts. This aberrant immune response may intrinsically predispose IBD patients to infectious complications. Moreover, immunosuppressive medications used to treat IBD including corticosteroids, thiopurines, methotrexate, calcineurin inhibitors, anti-tumor necrosis factor (anti-TNF) agents and other biologics, further increase patients' susceptibility to opportunistic infections. Herpes zoster (HZ), also known as shingles, is an opportunistic viral reactivation often observed in IBD patients with several case reports demonstrating complicated or disseminated disease in those on immunosuppression. While HZ vaccination is recommended in all immunocompetent adults aged ≥60 years, as a live virus vaccine, it is currently contraindicated in IBD patients on anti-TNF therapy and in other significantly immunocompromised patient groups. While caution is still warranted in these circumstances, recent clinical data has emerged which has prompted us to review and examine the universal approach to HZ vaccination in the immunosuppressed IBD population. In the following narrative review, we will discuss and provide an overview of the clinical manifestations, incidence, management and prevention of HZ in the IBD patient.

  17. The effect of valtrex on T cell subset and IL2, IL6 and IL10 level in patients with herpes zoster

    Institute of Scientific and Technical Information of China (English)

    Gui-E Wang; Jian Chen; Ling Chen

    2015-01-01

    Objective:To explore the effects of valtrex on T cell subset and IL2, IL6 and IL10 level in patients with herpes zoster.Methods: 120 patients with herpes zoster in our hospital were analyzed. The serum T cell subset and IL2, IL6 and IL10 were detected by Western Blotting. Healthy volunteers were enrolled as control group.Results: The CD4+ level was increased significantly while the CD8+ decreased significantly, and the ratio of the two increased too (P all<0.01). The IL6 and IL10 levels were increased significantly (P<0.01). But no significant change in IL2 level was observed.Conclusion:Valtrex is effective on herpes zoster by regulating T cell subset, IL6 and IL10 levels.

  18. Research Progress of Pricking and Cupping Treatment of Herpes Zoster%刺络拔罐治疗带状疱疹研究进展

    Institute of Scientific and Technical Information of China (English)

    邢菁; 付于

    2012-01-01

    Herpes zoster is a common skin disease, which always happens in spring and autumn in the elderly patients and seriously affects the quality of life. This paper summarizes the research progress of cupping treatment of herpes zoster in recent years, including a preliminary understanding of herpes zoster.%带状疱疹是临床上常见皮肤病,以春、秋季多见,好发于中老年人,严重影响患者的生活质量.文章总结了近年来刺络拔罐治疗带状疱疹的研究进展,并包含笔者对带状疱疹的初步认识.

  19. Integrated Approach to Understanding the Treatment of Herpes Zoster%综合方法治疗带状疱疹的体会

    Institute of Scientific and Technical Information of China (English)

    李如意

    2011-01-01

    目的:了解综合方法治疗带状疱疹的现状和进展.方法:通过对目前已知的综合方法治疗带状疱疹的治疗原则和方案,进行阐述与分析.结果:传统的单一疗法存在局限性.讨论:综合方法治疗是今后带状疱疹的趋势.%Objective: To understand the integrated approach to the treatment status and progress of herpes zoster.Methods: The currently known method of treatment of herpes zoster integrated treatment principles and programs, described and analyzed. Results: The limitations of a single therapy. Discussion: an integrated approach to treatment is the future trend of herpes zoster.

  20. Clinical Misdiagnosis of Herpes Zoster and the Countermeasures%带状疱疹临床误诊分析及对策

    Institute of Scientific and Technical Information of China (English)

    杜策

    2016-01-01

    Objective To analyze the causes of herpes zoster misdiagnosis and to put forward the countermeasures to reduce the oc-currence of misdiagnosis. Methods The clinical data of 117 cases with herpes zoster were collected and analyzed. Results Herpes zos-ter misdiagnosis occurred in almost every department, department of internal medicine, department of surgery and department of rehabil-itation had the higher occurrence;herpes zoster on chest, abdomen, head, face and neck was often misdiagnosed;the misdiagnosis of her-pes zoster occurred more in the middle-age and elderly. Conclusions Different causes lead to the misdiagnosis of herpes zoster;more at-tention should be paid and certain countermeasures should be taken to reduce the occurrence of misdiagnosis.%目的:分析带状疱疹误诊原因,并提出减少误诊的对策。方法收集我院皮肤科确诊为带状疱疹117例患者的临床资料,进行分析、总结。结果带状疱疹误诊见于临床各科,尤以内科、外科、康复科等科室所占比例较高;误诊部位以胸腹部、头面颈部居多;误诊年龄以中老年患者居多。结论带状疱疹误诊原因较多,应该多方面加以重视,并采取相应对策,减少误诊的出现。

  1. 恶性肿瘤伴发泛发性带状疱疹的治疗%Treatment for malignant tumors complicated with disseminated herpes zoster

    Institute of Scientific and Technical Information of China (English)

    付艳; 毕益明; 陈秀芳; 陈兴秀; 江志勇; 郑东星; 王淑燕

    2012-01-01

    Objective To explore the treatment for malignant tumors complicated with disseminated herpes zoster, and then compare with malignant tumors complicated with unilateral herpes zoster.Methods The data on 9 patients with malignant tumors and complicated with disseminated herpes zoster who had been treated from January 2000 to July 2011 were retrospectively analyzed,and so were the data on the 28 patients complicated with unilateral herpes zoster herpes zoster who had been treated during the same time.Results There was a significant difference in the CD4/CD8 rate between the patients with disseminated herpes zoster and those with unilateral herpes zoster ( 44.44% vs.10.71% or 4/9 vs.3/28,P < 0.05 ).Time to scar formation differed significantly between the patients with disseminated herpes and those with unilateral herpes zoster ( [7.44 ± 1.926]d vs.[3.89 ± 0.598]d,P<0.01 ).Conclusions The immune function is weaker in malignant tumor patients complicated with disseminated herpes zoster than in those with local herpes zoster.Time to scar formation is also longer in the patients with disseminated herpes zoster.%目的 对恶性肿瘤伴发的泛发性带状疱疹的治疗进行探讨,并与恶性肿瘤伴发的局限于单侧的带状疱疹进行统计学分析.方法 回顾分析我院自2000年1月至2011年7月住院期间共收治9例泛发性带状疱疹病人,同期收治恶性肿瘤伴发局限性带状疱疹28例,并对其进行统计学分析.结果 恶性肿瘤伴发泛发性带状疱疹患者CD4/CD8降低比例为44.44%(4/9),恶性肿瘤伴有单纯性带状疱疹患者CD4/CD8降低比例为10.71%(3/28);二者比较有统计学意义(P<0.05).恶性肿瘤伴发泛发性带状疱疹患者结痂时间平均为(7.44±1.92)天,恶性肿瘤伴发单纯性带状疱疹患者结痂时间平均为(3.89±0.598)天,二者比较有显著统计学差异(P<0.01).结论 恶性肿瘤伴发泛发性带状疱疹患者免疫功能低于恶性肿瘤伴发单纯

  2. Nursing of Hospitalized Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated by Wound Infection after Herpes Zoster%慢性阻塞性肺疾病急性加重期住院患者并发带状疱疹感染后创面的护理

    Institute of Scientific and Technical Information of China (English)

    刘映兰

    2013-01-01

    Summarizing 1 case of chronic obstructive pulmonary diseases acute exacerbation(AECOPD) patients complicated with wound infection after herpes zoster.In AECOPD patients with long duration and application fight infection in patients with long-term hospitalization and glucocorticoid treatment leads to the body resistance was poor,the wound area was large,serious infection,difficult to healing,healing in humid environment theory,under the guidance of the wet sex therapy,using metronidazole injection plus gentamycin local wet apply affected part and ribavirin injection,prescribed antibiotics and asthma, eliminating phlegm to bluff and pain relief support treatment,combined with regular skin care,made the patient’s psychological nursing and health education, continuous and effective nursing wounds,and is accelerate the healing.%  总结1例慢性阻塞性肺疾病急性加重期(AECOPD)患者并发带状疱疹后创面感染的护理。由于年老体弱同时伴有多种并发症,最突出的症状为缺氧。缺氧导致皮肤神经营养不良,抵抗力下降造成多种致病菌感染。且患者长期住院应用抗感染、糖皮质激素等治疗导致身体抵抗力差,伤口面积大,感染严重,难愈合等特点,在湿润环境愈合理论的指导下,采用了湿性疗法,选用甲硝唑注射液加庆大霉素和利巴韦林注射液局部湿敷患处,遵医嘱全身使用抗生素、抗病毒、平喘、化痰、强心、利尿和止痛等对证支持治疗,结合常规皮肤护理、做好患者的心理护理和健康教育,使创面得到连续有效的护理,加快了愈合速度。

  3. Treatment of Abdominal Segmental Hernia, Constipation, and Pain Following Herpes Zoster with Paravertebral Block.

    Science.gov (United States)

    Kim, Saeyoung; Jeon, Younghoon

    2015-01-01

    Herpes zoster (HZ) most commonly occurs in elderly patients and involves sensory neurons resulting in pain and sensory changes. Clinically significant motor deficits and visceral neuropathies are thought to be relatively rare. A 72-year-old man presented with abdominal segmental hernia, constipation, and pain following HZ in the left T9-10 dermatome. Sixteen days before presentation, he had developed a painful herpetic rash in the left upper abdominal quadrant. Approximately 10 days after the onset of the rash, constipation occurred and was managed with daily oral medication with bisacodyl 5 mg. In addition, 14 days after the onset of HZ, the patient noticed a protrusion of the left upper abdominal wall. Abdominal x-ray, ultrasound of the abdomen, and electrolyte analysis showed no abnormalities. General physical examination revealed a reducible bulge in his left upper quadrant and superficial abdominal reflexes were diminished in the affected region. Electromyographic testing revealed denervational changes limited to the left thoracic paraspinal muscles and supraumbilical muscles, corresponding to the affected dermatomes. He was prescribed with 500 mg of famciclovir 3 times a day for 7 days, and pregabalin 75 mg twice a day and acetaminophen 650 mg 3 times a day for 14 days. However, his pain was rated at an intensity of 5 on the numerical analogue scale from 0 (no pain) to 10 (worst pain imaginable). A paravertebral block was performed at T9-10 with a mixture of 0.5% lidocaine 3 mL and triamcinolone 40 mg. One day after the procedure, the abdominal pain disappeared. In addition, 5 days after the intervention, the abdominal protrusion and constipation were resolved. He currently remains symptom free at a 6 month follow-up.

  4. Clinical Analysis on 18 Cases of Child Herpes Zoster and Review the Literature%儿童带状疱疹18例及文献复习

    Institute of Scientific and Technical Information of China (English)

    杨珊; 迪丽努尔·阿布都热依木; 普雄明

    2013-01-01

    目的 探讨儿童带状疱疹的临床特征.方法 回顾性分析2008年1月-2011年12月本科收治的18例儿童带状疱疹的临床资料并进行文献复习.结果 儿童带状疱疹有轻微的前驱症状,皮疹少且散在分布,神经痛轻微,病程短(2 ~7d),且不发生后遗神经痛.结论 儿童带状疱疹临床少见、症状轻微,发病诱因以感染常见.%Objective To discuss the clinical features of children herpes zoster. Methods The pathogenesis,symptoms, experiences and treatments of eighteen children with herpes zoster were analysised. Results The children herpes zoster had minor precursory symptoms. The skin rash on children was few and scattered, neuralgia was slight in children, and course in children was short(2 ~7d). No PHN happened in children. Conclusion Children herpes zoster is rare in the clinic,clinical symptoms is minor. Infection was the common predisposing factor.

  5. AIDS病人眼部带状疱疹病毒感染病例分析%Herpes zoster virus infection case analyses the AIDS eye part

    Institute of Scientific and Technical Information of China (English)

    王寅威

    2008-01-01

    Objective Discuss the ponderance,prognosis,treatment and prophylaxis that the AIDS patient eye part herpes zoster virus opportunistic infection.Method Herpes zoster opportunistic infection case carries out retrospect nature analysis on the AIDS eye part friendship hospital ophthalmology outpatient service makes a definite diagnosis.Result The AIDS eye part herpes zoster virus opportunistic infection inflammation is grave,the pole curing difficulty,the prognosis is bad.Conclusion The herpes zoster opportunistic infection the AIDS disease eye part duplicating each other in taking precautions against and early phase discovers,cures AIDS,ocular infection by to treat long ago being nice%目的 探讨AIDS病人眼部带状疱疹病毒机会性感染的严重性、预后、治疗以及预防.方法 医院眼科门诊确诊的AIDS眼部带状疱疹机会性感染病例行回顾性分析.结果 AIDS眼部带状疱疹病毒机会性感染炎症严重,治疗困难,预后极差.结论 AIDS病眼部带状疱疹性机会性感染重在预防和早期发现,治疗AIDS眼部感染以早治疗为佳.

  6. Alterations of electroencephalogram in patients with headache after herpes zoster virus infection%带状疱疹后头痛的脑电图改变

    Institute of Scientific and Technical Information of China (English)

    徐心耕; 陈慧娟; 高琳; 张建

    2015-01-01

    Objective To investigate alerations in electroencephalogram in patients with headache post infection of herpes zoster virus. Methods A retrospective analysis of electroencephalogram of 58 patiens with headache was carried out.Results In patients with headache post herpes zoster virus infection, abnormal rate of electroencephalogram was 87%. While in group without history of herpes zoster virus infection, the abnormal rate of electroencephalogram was 12%.Conclusion Patients with headache post herpes zoster virus infection had higher rates of abnormality in electroencephalogram.%目的:探讨带状疱疹病毒感染后头痛患者脑电图异常。方法:对58例头痛患者的脑电图进行回顾性分析。结果:带状疱疹病毒感染后头痛组脑电图异常率87%,无疱疹病毒感染的患者脑电图异常率12%。结论:带状疱疹病毒感染后头痛患者脑电图异常发生率高。

  7. Rehabilitation of shoulder paresis caused by herpes zoster according to the International Classification of Functioning, Disability and Health A case report

    Institute of Scientific and Technical Information of China (English)

    Qiang Gao; Yonghong Yang; Chengqi He; Shaxin Liu

    2011-01-01

    We describe the case of a 73-year-old man with left shoulder paresis caused by a herpes zoster infection of the left C5 dermatomes. The patient had been affected by pain for 10 days, a skin rash on his left shoulder and back for 5 days, and weakness of his left shoulder for 2 days before admission. Electromyography revealed denervation discharges from the left supraspinatus, infraspinatus and deltoid muscles, which was compatible with radiculopathy showing after zoster infection. The patient was examined in accordance with the International Classification of Functioning, Disability and Health, and treated with range-of-movement and strengthening exercises as well as activities of daily living and social participation. At 14 months after the onset of the condition, muscle strength had returned to normal. Electromyography revealed that motor unit action potentials were largely normal. These results indicate that the rehabilitation of paresis caused by herpes zoster can obtain positive results with suitable movement training.

  8. Clinical Analysis of 50 Cases of Child Herpes Zoster%儿童带状疱疹50例临床分析

    Institute of Scientific and Technical Information of China (English)

    杨凤琼; 谢雪冰; 邓骥

    2011-01-01

    Objective To discuss the clinical features of children herpes zoster. Methods Fifty children with herpes zoster were compared with 50 cases of adults herpes zoster on their symptoms, experiences and treatments.Result The children herpes zoster had minor precursory symptoms(24% ). The skin rash on children was few and scattered while on adlut heavy. Neuralgia was slight in children but obvious in adult. and course in children was (7.5 ± 1. 8 d) and in adult was ( 18 ±2.5 d) respectively. No PHN happened in children but about 56% in adult patients. Discussion The incidence rate of children herpes zoster is low, and most of them have inducement.%目的 探讨儿童带状疱疹的临床特征.方法 分析50例儿童带状疱疹的诱因、症状、体征及治疗,并与同期50例成人带状疱疹患者临床资料相对照.结果 儿童带状疱疹有轻微前驱症状(24%),皮疹少且散在.神经痛轻微,病程短(7.5±1.8 d),且不发生后遗神经痛;而成人带状疱疹则皮疹重,神经痛明显,病程长(18±2.5d),有后遗神经痛(56%).讨论相对于成年人,儿童带状疱疹发病率低,发病多有诱因.

  9. 针刺放血结合云南白药外敷治疗急性期带状疱疹30例%Clinical Observation on the Treatment of Acute Herpes Zoster by Bloodletting plus Cupping and Yunnan Baiyao External Application

    Institute of Scientific and Technical Information of China (English)

    马广昊

    2015-01-01

    Objective:To investigate the clinical efficacy of bloodletting -cupping combined with Yunnan Baiyao therapy on herpes zoster.Methods:Sixty patients with herpes zoster were randomly allocated into two groups.The treatment group with 30 patients were received pricking bloodletting therapy plus cupping and Yun-nan Baiyao,and the control group with 30 patients were received acupuncture treatment.10 days after the treat-ment, the VAS score was recorded for a comparison of the therapeutic effects.Results:At the end of treatment, the total efficacy rate was 73.33%in the treatment group, which was higher than 36.67%in the control group (P<0.05).Conclusion:Compared with acupuncture, bloodletting therapy plus cupping combined with Yun-nan Baiyao has a better therapeutic effect on herpes zoste than traditional acupuncture therapies.%目的:观察放血结合云南白药外敷治疗带状疱疹的临床疗效。方法:将60例带状疱疹患者随机分为两组,治疗组30例采用梅花针叩刺放血结合云南白药治疗,对照组30例采用常规针灸疗法治疗,治疗1个疗程后观察疼痛缓解率及疗效并进行 VAS 评分,进行疗效对比。结果:治疗组痊愈率为73.33%,对照组痊愈率为36.67%,两组比较差异有统计学意义( P<0.05)。结论:放血疗法结合云南白药外敷治疗带状疱疹优于传统针刺疗法。

  10. 中西医结合治疗带状疱疹性角膜炎%Herpes Zoster Keratitis was Treated by Traditional Chinese Medicine and Western Medicine

    Institute of Scientific and Technical Information of China (English)

    何静

    2012-01-01

    Herpes zoster keratitis is a kind of unilateral skin and eye disease caused by neurotropic virus (the varicella-zoster virus) . Herpes zoster kertitis usually is treated with antiviral agent and antiviral drops. Now we treat herpes zoster kertitis with "Longdan Xiegan Decoction" to improve immunity and detoxicate. It is quite effective for shortening duration of disease and consolidating curative effect.%带状疱疹性角膜炎是嗜神经病毒(水痘一带状疱疹病毒)引起的不越过中线的单侧皮肤、眼部疾患,3/4的病例角膜被侵犯.通常用西药抗病毒药口服,抗病毒眼药局部治疗.辅以中药龙胆泻肝汤加减治疗后能提高全身抵抗力,固本排毒,对缩短痛程,巩固疗效是非常有益的.

  11. 清热解毒法治疗带状疱疹43例%Antipyretic and Antidotil Therapy to Treat 43 Cases of Herpes Zoster

    Institute of Scientific and Technical Information of China (English)

    王瑾

    2001-01-01

    Objective: To observe the clinical effect of antipyretic and antidotal on herpes zoster disease. Methods: To adapt both oral and external antipyretic and antidotil herb to treating 43 cases of herps zoster patients. Results: Using antipyretic and antidotal herb can shorten the course of herps zoster. Conclusion: Both oral and external antipyretic and antidotil herb could inhibit either herpes' virus or caricella virus.%目的:观察和验证清热解毒类中药对带状疱疹的临床功效。方法:对43例带状疱疹患者均采用中药清热解毒内治外用。结果:清热解毒法治疗能缩短带状疱疹病程,控制临床症状。结论:清热解毒法内外综合治疗对水豆-带状疱疹病毒有杀灭,抑制作用。

  12. Zosteriform lichen planus after herpes zoster: report of a new case of Wolf's isotopic phenomenon and literature review.

    Science.gov (United States)

    Lora, Viviana; Cota, Carlo; Kanitakis, Jean

    2014-11-15

    The Wolf's isotopic phenomenon corresponds to the occurrence of a skin disease at a body site affected previously by a different, already healed dermatosis. We report a 74-year-old man who presented with a zosteriform eruption consisting of erythematous-scaly, slightly pruritic papules on the right flank some weeks after herpes zoster (HZ) had healed on the same area. Histologic examination showed typical changes of lichen planus, confirming the diagnosis of post-HZ zosteriform lichen planus (ZLP). The lesions regressed with topical steroid treatment. Zosteriform lichen planus (ZLP) is one example of Wolf's isotopic phenomenon appearing after HZ. So far, only 17 cases have been reported in the literature. The precise pathogenesis of ZLP is not well known, although persisting viral proteins could be responsible for the hypersensitivity reaction. We review and discuss the salient clinicopathologic features of this rare entity based on a thorough literature review.

  13. 184例带状疱疹的诊疗体会%Experience in Diagnosis and Treatment of 184 Cases of Herpes Zoster

    Institute of Scientific and Technical Information of China (English)

    李冰皓

    2016-01-01

    目的:探讨带状疱疹的治疗要点。方法选取本院2013年至今收治的184例带状疱疹患者作为观察对象,分析带状疱疹的治疗原则及各期的治疗方法。结果经过内外兼治的方法184例患者均达到了理想的效果,其中痊愈142例,显效36例,有效6例。结论对带状疱疹必须要抗病毒和恢复受损的神经同时治疗,尽量做到早期用药。配合红蓝光照射治疗更能够有效修复受损的神经组织,改善患者的疼痛症状,值得在临床中推广应用。%Objective To study the treatment of herpes zoster. Methods 184 cases of herpes zoster treated in our hospital from 2013 to the present were selected as the observation object, Analysis of herpes zoster treatment principles and the various stages of treatment. Results After internal and external treatment, 184 cases achieved satisfactory results, Among them, 142 cases were cured, 36 cases were markedly effective, and 6 cases were effective. Conclusion Herpes zoster must be treated with antiviral and recovery of damaged nerve simultaneously, try to do early use of drugs. Combined with red and blue light irradiation treatment can effectively repair the damaged nerve tissue, improve the pain symptoms of patients, it is worth in clinical application.

  14. MEBO治疗带状疱疹23例疗效观察%The Efficacy of MEBO in Treating 23 Cases of Herpes Zoster

    Institute of Scientific and Technical Information of China (English)

    唐广立; 王洪昌

    2001-01-01

    Objective:To find out a new method for treating herpes zoster. Method:23 cases of herpes zoster were treated with MEBO(MEBO grou)and 22cases were treated with conventional method (control group).Result: All the cases healed. In MEBOgroup, the wound healing time was shorter than that in the control group(P<0.01).Con-clusion:MEBO is effective for treating herpes zoster. It is easy to use and its efficacy is satifactory%目的:探讨带状疱疹新的治疗方法.方法:治疗组23例局部采用MEBO暴露或包扎治法,对照组22例采用传统疗法.结果:两组病人均治愈,治疗组中22例疼痛缓解,而对照组只有14例缓解(P<0.05).XFK YWX :治疗带状疱效果确切,简单易行,值行推广.

  15. 针灸联合中药治疗带状疱疹%Treating herpes zoster by acupuncture and moxibusion plusTCM medicine

    Institute of Scientific and Technical Information of China (English)

    于永娜; 李玲; 贾丽华

    2015-01-01

    目的:探讨带状疱疹的治疗疗效。方法:选取120例带状疱疹患者进行针灸联合中药的治疗。结果:120例患者治疗后,102例治愈,占85%,10例显效,占10%,8例未愈,占5%。结论:针灸联合中药治疗带状疱疹有显著的疗效。%Objective: To study clinical efficacy of acupuncture and moxibusion plus TCM medicine on herpes zoster. Methods: 120 cases with herpes zoster were selected, and received acupuncture and moxibusion plus TCM medicine. Results: In 120 cases, 102 cases were cured (85%), 10 cases were markedly improved (10%), 8 cases were ineffective (5%). Conclusion: Acupuncture and moxibusion plus TCM medicine showed remarkable efficacy on herpes zoster.

  16. Perspectives on the impact of varicella immunization on herpes zoster. A model-based evaluation from three European countries.

    Directory of Open Access Journals (Sweden)

    Piero Poletti

    Full Text Available The introduction of mass vaccination against Varicella-Zoster-Virus (VZV is being delayed in many European countries because of, among other factors, the possibility of a large increase in Herpes Zoster (HZ incidence in the first decades after the initiation of vaccination, due to the expected decline of the boosting of Cell Mediated Immunity caused by the reduced varicella circulation. A multi-country model of VZV transmission and reactivation, is used to evaluate the possible impact of varicella vaccination on HZ epidemiology in Italy, Finland and the UK. Despite the large uncertainty surrounding HZ and vaccine-related parameters, surprisingly robust medium-term predictions are provided, indicating that an increase in HZ incidence is likely to occur in countries where the incidence rate is lower in absence of immunization, possibly due to a higher force of boosting (e.g. Finland, whereas increases in HZ incidence might be minor where the force of boosting is milder (e.g. the UK. Moreover, a convergence of HZ post vaccination incidence levels in the examined countries is predicted despite different initial degrees of success of immunization policies. Unlike previous model-based evaluations, our investigation shows that after varicella immunization an increase of HZ incidence is not a certain fact, rather depends on the presence or absence of factors promoting a strong boosting intensity and which might or not be heavily affected by changes in varicella circulation due to mass immunization. These findings might explain the opposed empirical evidences observed about the increases of HZ in sites where mass varicella vaccination is ongoing.

  17. Clinical Analysis of 12 HIV-infected Patients with Herpes Zoster%HIV感染并发带状疱疹12例临床分析

    Institute of Scientific and Technical Information of China (English)

    张更建; 张信江; 罗显华; 董泽令; 黄健; 陈龙庆; 王磊

    2013-01-01

    Objective To explore the clinical characteristics of HIV-infected patients with herpes zoster. Methods A retrospective analysis was performed on patients diagnosed as HIV infection with herpes zoster from November 2008 to October 2011 in our hospital. Results There were 12 HIV-infected patients with herpes zoster, male nine cases, female three cases, aged 25 to 58 years, average 35 years old. Eight cases were farmers, one was worker, two cases were individual and the other one was company staff. All the patients had neuropathic pain syndromes, five cases of them paining obviously. Patients were all with the two nerve branches innervating the area except one . 11 cases were cured, the other one was better. There were two cases of HIV patients diagnosed in the first year, four cases in the second year and six cases in the third year. The incidence of HIV increased with year. Conclusion HIV infection complicated with herpes zoster easily. Herpes zoster should be recognized as a marker condition indicating the necessity of screening for HIV. Obviously neuropathic pain and larger scale of rash always occurred in the HIV patients with herpes zoster. The common treatment of HIV patients with herpes zoster were using medicine with antivirus, nerve nutrition, diminishing inflammation acetanilide and enhancing immunologic function, but not glucocorticoid. The treatment alleviated the symptom effectively.%目的 探讨HIV感染者并发带状疱疹的临床特点.方法 回顾性分析2008年11月-2011年10月本科收治的12例HIV感染并发带状疱疹患者的临床资料.结果 男9例,女3例;年龄25~58岁,大于50岁1例.农民8例,工人1例,个体2例,职员1例.11例皮损分布≥2个神经分支支配区,均出现神经痛症状,其中5例疼痛明显.临床治愈11例,好转1例.三年间检出HIV感染并发带状疱疹者分别为2例、4例和6例.结论 HIV感染者易并发带状疱疹,带状疱疹可为HIV感染的首要症状.HIV感染并发带状

  18. Prevention of herpes zoster and its complications: from the clinic to the real-life experience with the vaccine.

    Science.gov (United States)

    Giovanni, Gabutti; Nicoletta, Valente; Parvanè, Kuhdari; Silvia, Lupi; Armando, Stefanati

    2016-12-01

    The erpes zoster is an acute viral illness characterized by a vesicular rash of unilateral distribution, which can eventually cause severe complications, such as post-herpetic neuralgia, ophthalmic zoster, stroke or other neurological complications. In Europe, an incidence of between 2.0 and 4.6 cases per 1000 person-years is estimated, with an increase after 50 years of age. Currently, the therapeutic options for are only partially effective in limiting the acute phase, while the management of complications is frequently complex and not satisfactory. The overall burden of the disease and the elevated costs associated with diagnosis and clinical and therapeutic management led to the development of a new preventive approach through a live attenuated virus vaccine. The vaccine now available decreases the incidence of the disease, post-herpetic neuralgia and the burden of illness. Moreover, the vaccine is safe and well tolerated and it seems to confer long-term protection. Based on the clinical results and evidence provided by the Health Technology Assessment, several countries introduced immunization although with different recommendations and methods of funding.

  19. Predictors of postherpetic neuralgia in patients with herpes zoster: a pooled analysis of prospective cohort studies from North and Latin America and Asia

    Directory of Open Access Journals (Sweden)

    Kosuke Kawai

    2015-05-01

    Conclusions: In addition to older age and severe acute pain, this study suggests that impaired physical and social functioning from acute zoster pain may play a role in the development of PHN in this prospective cohort study of HZ patients from North and Latin America and Asia.

  20. 三氧化二砷治疗血液病后合并带状疱疹的临床研究%Clinical analysis of hematologic disorders complicated with herpes zoster after treating with arsenic trioxide

    Institute of Scientific and Technical Information of China (English)

    张旗; 慕俐君; 王晓波; 李莉; 康志杰; 闫金松

    2011-01-01

    Objective To explore the increasing risk of herpes zoster and its possible mechanisms for hematologic disorders treated with arsenic trioxide (ATO). Methods The cases were divided into study group (with ATO) and control group (without ATO). The incidence rate of herpes zoster was compared between the two groups, and then the average cycles of chemotherapy were compared between the patients complicated with herpes zoster or not in study group. Results The rate of herpes zoster was significantly higher in study group than that in control group (χ2 =4.492, P =0.034). The rates of herpes zoster were 23.95 % (23/96) in study group and 7.89 % (3/38) in control groups. Patients in study group with herpes zoster had received 7.60 cycles and those without herpes zoster 7.72 cycles of chemotherapy on average (Z=0.976, P=0.296).Conclusion The risk of herpes zoster complication in hematologic disorders was increased after ATO treatment which probably activated varicella-zoster virus.%目的 分析三氧化二砷(ATO)治疗血液病后合并带状疱疹感染患者的临床特征及其可能的发生机制.方法 将研究对象分为研究组(应用ATO)和对照组(未应用ATO),观察两组带状疱疹发病率,以及研究组中发生带状疱疹和未发生带状疱疹患者的平均化疗次数.结果 研究组带状疱疹发病率为23.95%(23/96),发生带状疱疹者平均化疗7.60次,未发生带状疱疹者平均化疗7.72次(Z=0.976,P=0.296);对照组带状疱疹发病率7.89%(3/38),两组间带状疱疹发病率差异有统计学意义(χ2=4.492,P=0.034).结论 ATO治疗血液疾病可以增加带状疱疹的发病率,可能与其激活水痘-带状疱疹病毒有关.

  1. Treatment of herpes zoster with Clinacanthus nutans (bi phaya yaw) extract.

    Science.gov (United States)

    Sangkitporn, S; Chaiwat, S; Balachandra, K; Na-Ayudhaya, T D; Bunjob, M; Jayavasu, C

    1995-11-01

    A randomized, placebo-controlled trial of the efficacy of topical formulation of Clinacanthus nutans (Bi Phaya Yaw) extract was carried out in 51 patients with varicella-zoster virus infection. The study medication was applied five times daily for 7-14 days until the lesions were healed. The number of patients with lesion crusting within 3 days and with lesion healing within 7 days and 10 days were significantly greater in the C. nutans extract-treated group than the placebo group (p nutans extract-treated group than in the placebo group. There were no side effects of the study medication.

  2. Clinical Manifestations of Herpes Zoster, Its Comorbidities, and Its Complications in North of Iran from 2007 to 2013

    Directory of Open Access Journals (Sweden)

    Farhang Babamahmoodi

    2015-01-01

    Full Text Available Background. Herpes zoster infection is a painful worldwide disease. Inappropriate and delayed treatment causes prolongation of the disease with debilitating symptoms and postherpetic neuralgia. Method. A cross-sectional study evaluated shingles cases admitted in a teaching hospital with one-year followup in north of Iran from 2007 to 2013. Results. From 132 patients, 60.4% were male. Head and neck involvement occurred in 78 people (59.1%, thoracoabdominal region in 37 cases (28%, and extremities in 16 cases (12.1%, and one case (0.8% got multisites involvement. 54 cases (40.9% had predisposing factors including diabetes mellitus in 26 cases (19.7%, malignancy in 15 (11.4%, immunosuppressive medication in 7 (5.03%, HIV infection in 3 (2.3%, radiotherapy in 2 (1.5%, and tuberculosis in one patient (0.8%. The most common symptoms were pain (95.5%, weakness (56%, fever (31.1%, headache (30.3%, ocular complaints (27.3%, itching (24.2%, and dizziness (5.3%. 21 cases (15.9% had bacterial superinfection on blistering areas and overall 18 cases (13.6% had opium addiction. 4 cases (3.03% died during admission because of comorbidities. Postherpetic neuralgia was reported in 56 patients (42.5% after three months and seven cases (5% in one-year followup. Conclusion. Shortening interval between skin lesion manifestation and starting medication can accelerate lesion improvement and decrease disease course, extension, and complication.

  3. Gentiana scabra Bunge. Formula for Herpes Zoster: Biological Actions of Key Herbs and Systematic Review of Efficacy and Safety.

    Science.gov (United States)

    Wang, Kaiyi; Coyle, Meaghan E; Mansu, Suzi; Zhang, Anthony Lin; Xue, Charlie Changli

    2017-01-12

    This study reviewed the biological action of key herbs and evaluated systematically the efficacy and safety of oral Gentiana formula for herpes zoster (HZ). Experimental studies relevant to HZ were identified in PubMed. Randomized controlled trials using Gentiana formula for HZ were identified from nine English and Chinese databases. The primary outcome was evaluation of pain. Potential risk of bias was assessed. Meta-analysis was conducted using mean difference or risk ratio with 95% confidence intervals. Key herbs Gentiana scabra Bunge, Gentiana triflora Pall, Scutellaria baicalensis Georgi, and Gardenia jasminoides Ellis have shown antiinflammatory actions through inhibition of inflammatory cytokines and pro-inflammatory enzymes. Twenty-six clinical studies, involving 2955 participants, were included. Modified Gentiana formula resolved pain earlier than pharmacotherapy when used alone or combined with topical Chinese herbal medicine. Incidence of postherpetic neuralgia was lower (risk ratio 0.14, 95% confidence interval 0.03 to 0.74) with modified Gentiana formula plus topical Chinese herbal medicine. Mild adverse events were reported. Antiinflammatory actions of key herbs of Gentiana formula may explain clinical benefit in hastening pain relief and decreasing postherpetic neuralgia. Few adverse events were reported. Findings were limited by study quality and diversity in intervention and comparator dosage. Copyright © 2017 John Wiley & Sons, Ltd.

  4. 带状疱疹并发眼外肌麻痹11例临床分析%Analysis of 11 cases of herpes zoster complicated by extraocular muscles paralysis

    Institute of Scientific and Technical Information of China (English)

    杨晓鸥

    2012-01-01

    11例带状疱疹并发眼外肌麻痹患者均表现为眼睑及周围皮肤带状疱疹,疹后14天~2个月出现复视、斜视,持续4周~2个月.早期眼部外用、严重者系统应用糖皮质激素治疗可防止眼部后遗症的发生.%Eleven cases of herpes zoster complicated by extraocular muscles paralysis were reported. All cases presented herpes zoster of eyelids and nearby skin. Ten days to two months after the onset of herpes zoster, diplopia and esotropia occurred and lasted for 4 weeks to 2 months. Early application of glucocorticoids can prevent the occurrence of ocular sequelae.

  5. 带状疱疹愈合部位发生银屑病-Wolf's同位反应1例%Wolf's Isotopic Response: A Case of Psoriasis on the Site of Healed Herpes Zoster

    Institute of Scientific and Technical Information of China (English)

    胡晓莉; 瞿子伟; 范娟

    2012-01-01

    患者男,38岁.6周前左胸及背部出现带状疱疹皮损,2周后治愈.20d前,皮损愈合处出现簇集分布的鳞屑性红斑丘疹.皮损组织病理符合银屑病,提示为带状疱疹Wolf's同位反应.%A 38-year-old male presented with a 20-day Cluster of erythematous-desquamative lesions at the site of healed herpes zoster on his left chest-back region. He had been treated 6 weeks previously for herpes zoster of the same region. The lesions healed completely within 2 weeks. Based on histological findings, the patient had psoriasis.The clinical picture suggests Wolf's isotopic response on the site of healed herpes zoster.

  6. Herpes zoster as a cause of viral meningitis in immunocompetent patients.

    Science.gov (United States)

    Kangath, Raghesh Varot; Lindeman, Tracey Einem; Brust, Karen

    2013-01-09

    A 30-year-old Caucasian woman, without significant medical history or immunosuppression, presented with a 7-day history of severe headache and neck pain. The patient was presumed to have tension headache versus migraine, but was admitted because her symptoms did not resolve. A lumbar puncture was performed showing lymphocytic pleocytosis suggestive of aseptic meningitis and the patient was started on broad-spectrum antibiotics and acyclovir. After admission, a rash was discovered on her left lumbar region with vesicles on top of an erythematous base. Varicella PCR was conducted on the patient's cerebrospinal fluid which was positive. Upon further history, patient was found to have previous varicella infection as a child, but no prior episodes of dermatomal zoster. Therefore, this patient was found to have aseptic meningitis and cutaneous manifestation of disseminated varicella-zoster despite immunocompetence. Antibacterial treatment was discontinued and she was continued on acyclovir for 7 days with transition to valacyclovir for 2 additional weeks with good treatment response and symptom resolution.

  7. Acute retinal necrosis results in low vision in a young patient with a history of herpes simplex virus encephalitis.

    Science.gov (United States)

    Shahi, Sanjeet K

    2016-08-31

    Acute retinal necrosis (ARN), secondary to herpes simplex encephalitis, is a rare syndrome that can present in healthy individuals, as well as immuno-compromised patients. Most cases are caused by a secondary infection from the herpes virus family, with varicella zoster virus being the leading cause of this syndrome. Potential symptoms include blurry vision, floaters, ocular pain and photophobia. Ocular findings may consist of severe uveitis, retinal vasculitis, retinal necrosis, papillitis and retinal detachment. Clinical manifestations of this disease may include increased intraocular pressure, optic disc oedema, optic neuropathy and sheathed retinal arterioles. A complete work up is essential to rule out cytomegalovirus retinitis, herpes simplex encephalitis, herpes virus, syphilis, posterior uveitis and other conditions. Depending on the severity of the disease, the treatment options consist of anticoagulation therapy, cycloplegia, intravenous acyclovir, systemic steroids, prophylactic laser photocoagulation and pars plana vitrectomy with silicon oil for retinal detachment. An extensive history and clinical examination is crucial in making the correct diagnosis. Also, it is very important to be aware of low vision needs and refer the patients, if expressing any sort of functional issues with completing daily living skills, especially reading. In this article, we report one case of unilateral ARN 20 years after herpetic encephalitis.

  8. Influence of systemic immune and cytokine responses during the acute phase of zoster on the development of postherpetic neuralgia

    Institute of Scientific and Technical Information of China (English)

    Sheng-mei ZHU; Yong-min LIU; Er-dan AN; Qing-lian CHEN

    2009-01-01

    Postherpetic neuralgia (PHN) is a severe sequela of herpes zoster (HZ). Until now, only age and pain severity were considered predisposing factors for the development of PHN. We evaluated 49 patients with acute phase HZ, 10 of whom developed PHN (Group A) and 39 of whom did not develop PHN (Group B). Twenty-five healthy volunteers similar in age and gender distribution to the study group were recruited as controls (Group C). Numbers of serum CD3+ (pan-T lymphocytes), CD4+ (helper/inducer), and CD8+ (suppressor/cytotoxic) lymphocytes were decreased significantly in Groups A and B relative to the control group, but there were no statistical differences between Groups A and B. Interleukin (IL)-1β IL-6, tumor necrosis factor (TNF)-α, IL-8, and IL-10 were significantly elevated in Groups A and B relative to Group C. IL-6 was significantly higher in Group A than in Group B, and was significantly positively correlated with pain severity scored on a visual analog scale. Therefore, we suggest that the inflammatory response, especially that of IL-6, in the acute phase of HZ may be associated with hyperalgesia and the development of PHN.

  9. Incidence and clinical features of herpes simplex viruses (1 and 2) and varicella-zoster virus infections in an adult Korean population with aseptic meningitis or encephalitis.

    Science.gov (United States)

    Choi, Rihwa; Kim, Gyeong-Moon; Jo, Ik Joon; Sim, Min Seob; Song, Keun Jeong; Kim, Byoung Joon; Na, Duk L; Huh, Hee Jae; Kim, Jong-Won; Ki, Chang-Seok; Lee, Nam Yong

    2014-06-01

    Since there are limited data on the incidence and clinical findings of central nervous system (CNS) infection by three α-herpesviruses including human herpes simplex virus 1 (HSV-1), HSV-2 and varicella-zoster virus (VZV) in Korea, a retrospective analysis of clinical data and polymerase chain reaction (PCR) results was performed in patients who presented with suspicion of acute viral meningitis and/or encephalitis at the emergency department of a tertiary referral hospital in Seoul, Korea. During the 3-year study period, a total of 224 cerebrospinal fluid (CSF) samples from 224 patients were examined. Among the 224 patients, 135 (60.3%) patients were identified as having aseptic meningitis (n = 70, 51.9%), encephalitis (n = 41, 30.4%) or meningoencephalitis (n = 24, 17.8%) at discharge. Twenty-four (17.8%) patients were identified as having VZV meningitis (n = 16, 11.9%), VZV meningoencephalitis (n = 2, 1.5%), HSV-2 meningitis (n = 4, 3.0%), or HSV-1 encephalitis (n = 2, 1.5%). Of the 24 patients infected with the three herpesviruses, immunocompromised patients accounted for 33.3% (n = 8). Skin rashes were observed in half (n = 9) of the patients with VZV, and none with HSV-1 or HSV-2. One patient with VZV meningitis and four patients with brain parenchymal involvement had neurologic sequelae. In conclusion, three herpesviruses are important causative agents of CNS infectious disease with significant morbidity in adults, regardless of the immunologic status. Therefore, CSF should be examined for HSV-1, HSV-2, and VZV using sensitive diagnostic methods in all cases of adult patients with clinical manifestations of CNS disease in order to identify the correct etiology and to determine appropriate therapy.

  10. Herpes Zoster Associated Hospital Admissions in Italy: Review of the Hospital Discharge Forms

    Directory of Open Access Journals (Sweden)

    Giovanni Gabutti

    2009-09-01

    Full Text Available In Italy a specific surveillance system for zoster does not exist, and thus updated and complete epidemiological data are lacking. The objective of this study was to retrospectively review the national hospital discharge forms database for the period 1999-2005 using the code ICD9-CM053. In the period 1999-2005, 35,328 hospital admissions have been registered with annual means of 4,503 hospitalizations and 543 day-hospital admissions. The great part of hospitalizations (61.9% involved subjects older than 65 years; the mean duration of stay was 8 days. These data, even if restricted to hospitalizations registered at national level, confirm the epidemiological impact of shingles and of its complications.

  11. Herpes zoster como primeira manifestação de infeção por vírus varicela-zoster numa criança saudável

    Directory of Open Access Journals (Sweden)

    Catarina Carrusca

    2016-03-01

    Full Text Available O herpes zoster (HZ resulta da reativação do vírus varicela-zoster (VVZ. A incidência aumenta com a idade, sendo raro em crianças saudáveis. Descrevemos um caso de HZ oftálmico numa menina de 29 meses, previamente saudável. Apresentava febre e erupção cutânea vesicular dolorosa no território oftálmico do nervo trigémio. Sem história de varicela ou vacinação anti-varicela prévias. Teve contacto intrafamiliar com varicela aos dois meses de idade. A pesquisa do vírus nas vesículas por polimerase chain reaction foi positiva. Os títulos de IgG e IgM anti-vírus varicela-zoster foram inicialmente negativos, tendo ocorrido seroconversão oito semanas depois. Medicada com aciclovir endovenoso, recuperou sem sequelas. O HZ pode ocorrer em crianças previamente saudáveis, sem evidência de varicela anterior e com serologia para VVZ negativa. Tal pode ser explicado pela imaturidade do sistema imunológico, assim como pela transferência transplacentária de anticorpos maternos, aquando da infeção primária precoce.

  12. Serum cytokines, T lymphocyte subsets and STAT3 function in patients with herpes zoster as well as the intervention effect of mouse nerve growth factor

    Institute of Scientific and Technical Information of China (English)

    Yun Xu; Ling-Ling Tan; Kai Wang; Juan-Juan Zhang; Li-Jing Zhang

    2016-01-01

    Objective:To assess the levels of serum cytokines, T lymphocyte subsets and STAT3 in patients with herpes zoster as well as the intervention effect of mouse nerve growth factor. Methods:A total of 102 patients with herpes zoster were selected as observation group and received mouse nerve growth factor intervention, and 100 cases of normal people who received physical examination in our hospital during the same period as the healthy control group. The levels of serum Th1/Th2 cytokines, IgG subclass and complements and T lymphocyte subsets as well as STAT3 function of observation group before and after treatment and healthy control group were detected.Results: Serum IL-2 andγ-IFN levels of observation group after treatment were higher than those before treatment while IL-4, IL-5, IL-10 and TNF-α levels were lower than those before treatment (P<0.05); serum IgG1, IgG3, IgG4, C3 and C4 values of observation group after treatment were higher than those before treatment while IgG2 value was lower than that before treatment (P<0.05); CD3, CD4 and CD4/CD8 levels of observation group after treatment were higher than those before treatment while CD8 level was lower than that before treatment (P<0.05); STAT3, p-STAT3 and JAK2 expression levels of observation group after treatment were lower than those before treatment (P<0.05).Conclusions:There are abnormal immune system and STAT3 signaling pathway function in patients with herpes zoster, and mouse nerve growth factor intervention can restore multisystem balance and accelerate disease rehabilitation, and has positive clinical significance.

  13. 火针刀技术治疗带状疱疹临床观察%Clinical Observation of Cauterized Needle-knife Treatment of Herpes Zoster

    Institute of Scientific and Technical Information of China (English)

    唐胜修; 王小莲; 刘辛; 韦春华

    2011-01-01

    Objective :To observe the effect of cauterized needle-knife treatment of herpes zoster. Methods :44 cases of herpes zoster patients were divided into 2 groups according with random number table method,24 cases of cauterized needle-knife group ( group 1 ) and 20 cases of western medicine ( group 2). After the 2 groups were treated respectively, add up the whole scab time and changes in pain intensity of the 2 groups respectively, then make statistical comparison. Results: After treatments, the whole scab time of group 1 was significantly lower then that of group 2 (P < 0. 05), the pain score of group 1 was significantly lower than that of group 2 (P < 0.05). Conclusion: the herpes zoster treatment efficacy of cauterized needle-knife was superior to that of westem medicine.%目的:观察火针刀技术治疗带状疱疹的疗效.方法:带状疱疹患者44例,以随机数字表法分为两组,其中火针刀组24例,以火针刀治疗,西药组20例,以西药治疗,直至疱疹皮损处全部结痂为止.分别统计每组患者结痂所需时间及治疗前后疼痛程度评分,并加以比较.结果:火针刀组结痂所需时间明显少于西药组的时间(P<0.05),火针刀组治疗后疼痛评分明显少于西药组评分(P<0.05).结论:火针刀技术治疗带状疱疹疗效优于西药组.

  14. Hemicellulose dressing for skin lesions caused by herpes zoster in a patient with leukemia-an alternative dressing.

    Science.gov (United States)

    Chacon, Julieta; Ferreira, Lydia

    2009-01-01

     Herpes zoster is a painful disease that can develop in immunosuppressed children. Prolonged immunosuppression in leukemia patients can substantially delay healing of herpetic lesions. The purpose of this report was to evaluate the use of hemicellulose dressings as an alternative treatment for extensive herpetic lesions in an immunosuppressed child with leukemia. The hemicellulose dressing was applied to the lesions on the second day after debridement. After 36 days, the lesions were completely healed. The hemicellulose dressing was an effective resource for promoting complete epithelial healing.

  15. [Delirium during oral therapy of herpes zoster with acyclovir. Case report and brief review of central nervous system side-effects of acyclovir].

    Science.gov (United States)

    Braun, J S; Apel, I; Schäffer, S; Schumacher, M; Berger, M

    1998-11-01

    In differential diagnosis of a delir also adverse effects of medicaments have to be taken into account beside other causes. We report a case of an agitated delir with nocturnal disturbance of consciousness, confusion, restlessness and sleeplessness. This delir existed exclusively during the therapy of a cutaneous herpes zoster with zovirax-pills which can only be explained by a causal connection--after exclusion of other causes. As a so far undescribed predisposition for neurotoxicity of oral therapy with acyclovir signs of vascular encephalopathy were found in the patient's cranial magnetic resonance imaging. The central nervous side effects of acyclovir were summarized shortly.

  16. Cantharidin patches and intravenous administration of vitamin C in the concomitant treatment of herpes zoster:a case report%斑蝥素贴剂结合维生素C静脉注射辅助治疗带状疱疹1例

    Institute of Scientific and Technical Information of China (English)

    Martin Schencking; Karin Kraft

    2011-01-01

    @@ The diagnosis and therapy for herpes zoster (HZ) are frequently associated with consultation of a general practitioner and with hospital care.Although there are several serious complications of zoster such as ophthalmic, splanchnic, cerebral,and motor conditions, the most common and feared in immunocompetent adults is postherpetic neuralgia (PHN).Its definition is controversial.Recent data support the distinction between acute herpetic neuralgia (within 30 d of rash onset),subacute herpetic neuralgia (30 to 120 d after rash onset), and postherpetic neuralgia (defined as pain lasting at least 120 d from rash onset)[1-3].PHN is classified as a neuropathic pain that is associated with mechanical allodynia where normally innocuous tactile stimuli are perceived as painful[2].In actual studies it is reported that the incidence of HZ is 3.2 to 4.1 in 1 000 person-years[4, 5].

  17. 蛇串疮辨证施护55例体会%Experience of Nursing Based on Syndrome Differentiation for 55 Cases of Herpes Zoster

    Institute of Scientific and Technical Information of China (English)

    徐琳

    2012-01-01

    蛇串疮是疼痛性疱疹性皮肤病,文章从一般护理常规、辨证施护、皮肤护理、疼痛护理、情志护理及饮食护理等方面较详细阐述了蛇串疮的辨证施护体会,提示多方面联合进行中医护理可提高临床疗效.%Herpes zoster is a skin disease characterized by pain and herpes. The nursing experience was explained from many aspects, including nursing routine, nursing based on syndrome differentiation, skin nursing, pain nursing, emotion nursing and diet nursing. It is proved that TCM combined with western medicine can improve the effect.

  18. Measuring the burden of herpes zoster and post herpetic neuralgia within primary care in rural Crete, Greece

    Directory of Open Access Journals (Sweden)

    Lionis Christos D

    2011-12-01

    Full Text Available Abstract Background Research has indicated that general practitioners (GPs have good clinical judgment in regards to diagnosing and managing herpes zoster (HZ within clinical practice in a country with limited resources for primary care and general practice. The objective of the current study was to assess the burden of HZ and post herpetic neuralgia (PHN within rural general practices in Crete, Greece. Methods The current study took place within a rural setting in Crete, Greece during the period of November 2007 to November 2009 within the catchment area in which the Cretan Rural Practice-based Research Network is operating. In total 19 GP's from 14 health care units in rural Crete were invited to participate, covering a total turnover patient population of approximately 25, 000 subjects. For the purpose of this study an electronic record database was constructed and used as the main tool for monitoring HZ and PHN incidence. Stress related data was also collected with the use of the Short Anxiety Screening Test (SAST. Results The crude incidence rate of HZ was 1.4/1000 patients/year throughout the entire network of health centers and satellite practices, while among satellite practices alone it was calculated at 1.3/1000 patients/year. Additionally, the standardised incidence density within satellite practices was calculated at 1.6/1000 patients/year. In regards to the stress associated with HZ and PHN, the latter were found to have lower levels of anxiety, as assessed through the SAST score (17.4 ± 3.9 vs. 21.1 ± 5.7; p = 0.029. Conclusions The implementation of an electronic surveillance system was feasible so as to measure the burden of HZ and PHN within the rural general practice setting in Crete.

  19. The diagnostic significance of enzyme linked immuno-sorbent assay for herpes simplex, varicella zoster and cytomegalovirus retinitis.

    Directory of Open Access Journals (Sweden)

    Madhavan Hajib

    2003-01-01

    Full Text Available Purpose: To evaluate the diagnostic usefulness of enzyme linked immuno-sorbent assay (ELISA in single serum samples to associate herpes simplex virus (HSV, varicella zoster virus (VZV or cytomegalovirus (CMV with viral retinitis as against polymerase chain reaction (PCR on intraocular specimens. It was also designed to study the seroprevalence in normal healthy individuals, and the genomic prevalence of HSV, VZV and CMV in patients without an active viral inflammatory process. Methods: PCR for the detection of HSV, VZV and CMV genomes was done on 33 and 90 intraocular fluids from viral retinal patients and non-viral controls respectively. ELISA was done on 30 and 100 serum samples from viral retinitis patients and normal healthy controls respectively. Results: PCR did not detect HSV, VZV and CMV genomes except one, in which VZV-DNA was detected. ELISA showed prevalence rates of 28%, 83% and 90% for antibodies against HSV, VZV and CMV respectively in the normal population. In the 30 viral retinitis patients, PCR detected HSV-DNA in 2 (6.7%, VZV-DNA in 7 (23.3% and CMV-DNA in 6 (20.0% patients, while ELISA detected antibodies against HSV, VZV and CMV in 13 (43.3%, 24 (80.0% and 23 (76.7% patients respectively. ELISA was of value in indirect diagnosis only in 6 (20.0% as compared to 15 (50.0% of 30 patients by PCR, this difference was statistically significant (McNemar test, P value = 0.005. Conclusion: Serology by ELISA is no longer a useful diagnostic tool to associate HSV, VZV and CMV viruses with viral retinitis.

  20. Longitudinal study on oral shedding of herpes simplex virus 1 and varicella-zoster virus in individuals infected with HIV.

    Science.gov (United States)

    van Velzen, Monique; Ouwendijk, Werner J D; Selke, Stacy; Pas, Suzan D; van Loenen, Freek B; Osterhaus, Albert D M E; Wald, Anna; Verjans, Georges M G M

    2013-09-01

    Primary herpes simplex virus 1 (HSV-1) and varicella-zoster virus (VZV) infection leads to a life-long latent infection of ganglia innervating the oral mucosa. HSV-1 and VZV reactivation is more common in immunocompromised individuals and may result in viral shedding in saliva. We determined the kinetics and quantity of oral HSV-1 and VZV shedding in HSV-1 and VZV seropositive individuals infected with HIV and to assess whether HSV-1 shedding involves reactivation of the same strain intra-individually. HSV-1 and VZV shedding was determined by real-time PCR of sequential daily oral swabs (n = 715) collected for a median period of 31 days from 22 individuals infected with HIV. HSV-1 was genotyped by sequencing the viral thymidine kinase gene. Herpesvirus shedding was detected in 18 of 22 participants. Shedding of HSV-1 occurred frequently, on 14.3% of days, whereas solely VZV shedding was very rare. Two participants shed VZV. The median HSV-1 load was higher compared to VZV. HSV-1 DNA positive swabs clustered into 34 shedding episodes with a median duration of 2 days. The prevalence, duration and viral load of herpesvirus shedding did not correlate with CD4 counts and HIV load. The genotypes of the HSV-1 viruses shed were identical between and within shedding episodes of the same person, but were different between individuals. One-third of the individuals shed an HSV-1 strain potentially refractory to acyclovir therapy. Compared to HSV-1, oral VZV shedding is rare in individuals infected with HIV. Recurrent oral HSV-1 shedding is likely due to reactivation of the same latent HSV-1 strain.

  1. Early and reliable detection of herpes simplex virus type 1 and varicella zoster virus DNAs in oral fluid of patients with idiopathic peripheral facial nerve palsy: Decision support regarding antiviral treatment?

    Science.gov (United States)

    Lackner, Andreas; Kessler, Harald H; Walch, Christian; Quasthoff, Stefan; Raggam, Reinhard B

    2010-09-01

    Idiopathic peripheral facial nerve palsy has been associated with the reactivation of herpes simplex virus type 1 (HSV-1) or varicella zoster virus (VZV). In recent studies, detection rates were found to vary strongly which may be caused by the use of different oral fluid collection devices in combination with molecular assays lacking standardization. In this single-center pilot study, liquid phase-based and absorption-based oral fluid collection was compared. Samples were collected with both systems from 10 patients with acute idiopathic peripheral facial nerve palsy, 10 with herpes labialis or with Ramsay Hunt syndrome, and 10 healthy controls. Commercially available IVD/CE-labeled molecular assays based on fully automated DNA extraction and real-time PCR were employed. With the liquid phase-based oral fluid collection system, three patients with idiopathic peripheral facial nerve palsy tested positive for HSV-1 DNA and another two tested positive for VZV DNA. All patients with herpes labialis tested positive for HSV-1 DNA and all patients with Ramsay Hunt syndrome tested positive for VZV DNA. With the absorption-based oral fluid collection system, detections rates and viral loads were found to be significantly lower when compared to those obtained with the liquid phase-based collection system. Collection of oral fluid with a liquid phase-based system and the use of automated and standardized molecular methods allow early and reliable detection of HSV-1 and VZV DNAs in patients with acute idiopathic peripheral facial nerve palsy and may provide a valuable decision support regarding start of antiviral treatment at the first clinical visit.

  2. Gerstmann's syndrome following an acute herpes simplex encephalitis.

    Science.gov (United States)

    Ilchevsky, S; Boev, I; Kazakova, T

    1998-01-01

    The authors present a rare clinical case of a woman who developed Gerstmann's syndrome following an acute Herpes simplex viral encephalitis. Clinical observation and laboratory evaluation were performed during the acute phase of the disease. After that the follow-up continued for one-year period. The localization of the pathologic process was determined by computerized tomography, conducted periodically. The characteristics of the clinical picture are interpreted in the context of the contemporary concepts of the topical diagnosis of Gerstmann's syndrome. The possibility of a sudden onset of acute Herpes simplex viral encephalitis without a preceding febrile-intoxication syndrome is worth noting. Conclusions are drawn stressing the need of an early etiologic treatment and the importance of the rehabilitation activities during the convalescence period.

  3. Distrofia simpática reflexa pós herpes zoster

    OpenAIRE

    Minami,Catia Susana Harumi; Costa,Mônica Duarte; Antônio,Silvio Figueira; Chahade,Wiliam Habib

    2004-01-01

    A distrofia simpática reflexa (DSR) é uma síndrome dolorosa pouco entendida que consiste na presença de múltiplos sinais e sintomas incluindo dor, edema, alterações cutâneas distróficas e disfunção autonômica envolvendo uma ou mais extremidades. Nem sempre a DSR pós-herpes zóster é facilmente reconhecida. Poucos relatos dessa complicação foram publicados, o que torna interessante esta descrição. Apresentamos o caso de uma mulher branca, de 65 anos de idade cujos sinais e sintomas característi...

  4. 针灸治疗带状疱疹临床研究概况%The general situation ofAcupuncture treatment of herpes zoster in clinical research work

    Institute of Scientific and Technical Information of China (English)

    张爱珍

    2013-01-01

      介绍针灸治疗带状疱疹临床研究的进展及相关情况,对未来发展进行展望。%  This article describes the clinical studies progress and related information of acupuncture treatment of herpes zoster, future development prospects.

  5. 1例肾移植术后并发带状疱疹患者的药学监护体会%Experience on pharmaceutical care in a renal transplantion recipient with herpes zoster

    Institute of Scientific and Technical Information of China (English)

    吉小丽; 戴映; 宋洪涛

    2015-01-01

    Objective To report experience on pharmaceutical care in a renal transplantation recipient with herpes zoster . Methods The methods and measures of pharmaceutical care of a renal transplantation recipient with herpes zoster were retro‐spectively summarized .Results A safety ,effectiveness ,rationality of medication were significantly increased by pharmaceuti‐cal care in renal transplantation patient′s with herpes zoster and the patient′s quality of life was improved .Conclusion Pharma‐ceutical care was necessary and valuable to renal transplantation recipients with herpes zoster .%目的:报告肾移植术后并发带状疱疹患者的药学监护经验和体会。方法回顾性总结1例肾移植术后并发带状疱疹患者的药学监护方法和措施。结果通过药学监护,明显提高了肾移植术后并发带状疱疹患者用药的安全、有效、合理,改善了患者的生活质量。结论对肾移植术后患者实施药学监护非常有必要。

  6. 犀角地黄汤加减配合雄黄散治疗带状疱疹%Xijiaodihuang Decoction with Realgar Powder in Treating Herpes Zoster

    Institute of Scientific and Technical Information of China (English)

    林春华

    2013-01-01

    目的:探讨犀角地黄汤加减配合雄黄散治疗带状疱疹的疗效。方法回顾性分析2009~2012年应用犀角地黄汤加减内服配合雄黄散外敷治疗带状疱疹30例临床资料。结果29例治愈,治愈时间4~10 d,平均7 d。结论内外合治,疗效显著。%Objective: To investigate the curative ef ect of Xijiao Dihuang Decoction Combined with realgar powder in the treatment of herpes zoster. Methods:retrospective analysis of 2009 to 2012 of Xijiaodihuang decoction combined with realgar powder on the treatment of herpes zoster clinical data of 30 cases. Results: 29 cases were cured, the cure time short 4 days, the longest 10 days, an average of 7 days. Conclusion:internal and external treatment, curative ef ect.

  7. Facial herpes zoster infection precipitated by surgical manipulation of the trigeminal nerve during exploration of the posterior fossa: a case report

    Directory of Open Access Journals (Sweden)

    Mansour Nassir

    2009-09-01

    Full Text Available Abstract Introduction We present a case of herpes zoster infection (shingles precipitated by surgical manipulation of the trigeminal nerve root during an attempted microvascular decompression procedure. The pathogenesis of this phenomenon, as well as the importance and role of prophylactic acyclovir in its management, are discussed. Case presentation A 54-year-old Caucasian man with a classical long-standing left-sided V2 and V3 division primary trigeminal neuralgia refractory to medical management, underwent posterior fossa exploration for microvascular decompression via a standard retromastoid craniectomy. The patient had immediate and complete relief from pain. Three days after the operation, he developed severely painful vesicles with V2 and V3 dermatomal distribution. Rather than the classical paroxysmal, lancinating type of trigeminal neuralgia, the pain experienced by the patient was of a constant burning nature. A clinical diagnosis of herpes zoster (shingles was made after smear confirmation from microbiological testing. The patient was commenced on antiviral treatment with acyclovir. His vesicular rash and pain gradually subsided over the next two weeks. He remains asymptomatic one year later. Conclusions Postoperative shingles precipitated by trigeminal nerve manipulation during surgery for trigeminal neuralgia can be a distressing and demoralizing experience for the patient. A careful preoperative history, early recognition, and prompt antiviral therapy is necessary.

  8. Research status and development trends of herpes zoster vaccine%带状疱疹疫苗的研究现状及发展趋势

    Institute of Scientific and Technical Information of China (English)

    张勇; 赫宝双; 赵海波

    2012-01-01

    Original infection of varicella-zoster virus can induce varicella and then herpes when the virus is activated again. In recent years, with the progress of aging of domestic population, the incidence rate of herpes is increasing apparently, and there is no apparent therapeutic effect to treat post-herpetic neuralgia caused by herpes with antiviral drugs. Therefore, the prevention and therapy of herpes has been attached more and more importance for it has become an important public hygiene issue. The prevention of herpes with vaccine has been accepted by the society widely. In this article, we summarized the causative agent of herpes and the current situation of research and development of vaccine research.%水痘-带状疱疹病毒原发感染为水痘,再度被激活则引起带状疱疹(HZ).近年来,随着国内人口结构的老龄化趋势日益加重,HZ的发病率有明显上升的趋势,且引起的后遗神经痛使用抗病毒药物治疗无明显疗效.HZ的防治现已成为重要的公共卫生问题.采用疫苗预防HZ已经越来越被社会所接受.本文就该病原体及其疫苗方面的研究现状及进展作一综述.

  9. Clinical Analysis of 87 Cases Inpatients with Herpes Zoster in General Hospital%住院患者发生带状疱疹87例临床分析

    Institute of Scientific and Technical Information of China (English)

    孙晓燕; 张美芳; 马小萍; 党倩丽

    2012-01-01

    Objective To investigate the risk facters of inpatients with herpes zoster during hosipitalitation in general hospital. Methods Eighty-seven cases of inpatients with herpes zoster were analyzed by a retrospective way from January 2007 to January 2010. Results Eighty-seven patients were infected herpes zoster during hosipitalitation in 86 975 inpatients (0. 10% ). Fifty-four patients were infected herpes zoster during hosipitalitation in 44 913 inpatients who were more than 50 years old (0.12% ). Thirty-three patients were infected herpes zoster in 42 062 inpatients who were less than 50 years old (0.08% ). Eighty-seven patients with herpes zoster during hosipitalitation were suffered with another disease, in which 33 patients with cardiovascular disease, 18 patients with cancer, 10 patients with diabetes mellitus. Conclusion Over 50 age, with Cardiovascular disease, cancer and diabetes mellitus were risk factors of inpatient with herpes zoster during hosipitalitation%目的 探讨住院患者发生带状疱疹的危险因素.方法 对2007年1月-2010年1月本院住院患者住院期间87例发生带状疱疹患者的临床资料进行回顾性分析.结果 86 975例住院患者中,住院期间发生带状疱疹87例(0.10%),其中50岁以上住院患者44 913例,发生带状疱疹54例(0.12%);年龄<50岁的住院患者42 062例,共发生带状疱疹33例(发生率0.08%);87例带状疱疹患者所患基础疾病包括:心脑血管病(34例)、恶性肿瘤(18例)和糖尿病(10例).结论 年龄> 50岁、伴有心脑血管疾病、糖尿病和恶性肿瘤等是住院患者发生带状疱疹的高危险因素.

  10. 30 Cases Clinical Analysis of Diabetes Combining Recurrent Herpes Zoster%糖尿病合并复发性带状疱疹18例临床分析

    Institute of Scientific and Technical Information of China (English)

    张翠松

    2013-01-01

    Objective:To analyse the occurrence and treatment of diabetes combining recurrent herpes zoster.Methods:Information of 18 patients with diabetes combining recurrent herpes zoster was collected,and the occurrence and treatment of clinical was analyzed.Results:Out of 30 cases,28 patients experienced recurrence once and 2 cases twice.All the patients recovered through joint treatment.Conclusion:Diabetes combining with recurrent herpes zoster is not rare,the recurrent understanding of herpes zoster should be improved.Joint treatment by antiviral,nutrition nerve treatment is needed to prevent herpes zoster.%  目的:分析糖尿病合并复发性带状疱疹的发病特点与治疗体会。方法:收集18例糖尿病合并复发性带状疱疹患者的临床资料,并对其发病特点与治疗情况进行临床分析。结果:18例患者16例复发1次,2例复发2次,经过联合治疗患者均恢复正常。结论:糖尿病合并复发性带状疱疹并不少见,应提高对复发性带状疱疹的认识,治疗上应降糖联合抗病毒、营养神经治疗,防止带状疱疹后遗神经痛的发生。

  11. Price of pain: population-based cohort burden of disease analysis of medication cost of herpes zoster and postherpetic neuralgia

    Directory of Open Access Journals (Sweden)

    Friesen KJ

    2016-08-01

    Full Text Available Kevin J Friesen,1 Jamie Falk,1 Silvia Alessi-Severini,1 Dan Chateau,2 Shawn Bugden1 1College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; 2Department of Community Health Sciences, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada Background: Pain is a main symptom of herpes zoster (HZ, and postherpetic neuralgia (PHN is a frequent complication occurring in 5% to 15% of cases, causing moderate to severe neuropathic pain. A population-based observational study was conducted to evaluate the treatment patterns and economic burden of prescription drug treatment of HZ and PHN pain in the province of Manitoba (Canada over a period of 15 years. Methods: Administrative health care data, including medical and hospital separation records, were examined to identify episodes of HZ using International Classification of Diseases-9/10 codes between April 1, 1997 and March 31, 2014. Episodes of PHN were identified using medical and prescription claims. Incident use of analgesic, antidepressant, or anticonvulsant drugs was used to determine prescription pain costs. Results: The age-adjusted incidence of HZ increased from 4.7 episodes/1,000 person-years in 1997/98 to 5.7/1,000 person-years in 2013/14. PHN occurred in 9.2% of HZ cases, a rate that did not change over the study period (P=0.57. The annual cost to treat HZ pain rose by 174% from 1997/98, reaching CAD $332,981 in 2011/12, 82.8% (95% confidence interval [CI] 81.2%, 84.3% of which was related to PHN. The per episode cost of HZ rose by 111% from $31.59 (95% CI $25.35, $37.84 to $66.81 (95% CI $56.84, $76.78 and by 94% for PHN from $292 (95% CI $225, $358 to $566 (95% CI $478, $655. These increases were driven by increasing use of anticonvulsants, primarily gabapentin, which accounted for 57% of the increase in cost. Conclusion: There has been an increase in the incidence of HZ and PHN and in the average cost associated with the

  12. Analysis of the Effect of Nursing Intervention on 150 Cases of Patients with Herpes Zoster in Outpatient Department%150例门诊带状疱疹患者护理干预效果分析

    Institute of Scientific and Technical Information of China (English)

    吴丽环

    2016-01-01

    Objective To explore the effect of nursing intervention on 150 patients with herpes zoster patients. Methods The research and clinic from November 2013 to November 2015 a total of 150 patients with herpes zoster outpatient treated patients, all patients were randomly divided into two groups, which were control group and observation group, 75 cases of herpes zoster patients with herpes zoster outpatient clinic, two groups of patients were used in different types of nursing in-tervention. The control group of patients with herpes zoster outpatient take routine nursing, the observation group of patients with herpes zoster outpatient based on routine nursing methods on strengthening the implementation of nursing, nursing ef-fect, compared with the control group and the observation group of patients with herpes zoster outpatient for different nursing methods after the cessation time, pain time, time and healing time of herpes scab. Results In the observation group of pa-tients with herpes zoster outpatient nursing total efficiency was significantly higher than that of the control group of patients with herpes zoster outpatient and observation, symptoms of herpes zoster patients in outpatient group was significantly better than the control group of patients with herpes zoster outpatient, the card party t examination and comparison of two groups of herpes zoster patients nursing efficacy and disease situation obtains the p value of less than 0.05, the difference has sta-tistical significance. Conclusion The patients with herpes zoster outpatient in the base of routine nursing practice of inten-sive care, can effectively improve patients with herpes zoster disease cure rate, to a great extent help patients relieve pain pain, reduce the treatment time of patients, with good effect of nursing, therefore, is worth the clinical promotion.%目的:探讨护理干预对门诊带状疱疹患者150例的疗效。方法选取并研究该中心门诊于2013年11月—2015年11月

  13. Varicella Zoster Virus Promoter Sequences

    Science.gov (United States)

    1994-01-01

    71:2999-3003 . Dumas AM. Geelen JLMC. Maris W, and van der Noordaa J . 1980. Infectivity and molecular weight of varicella-zoster virus DNA. J. Gen...zusammenhang der 164 varizelen mit gewissenfallen von herpes zoster. weinklin. Wchschr. 22,1323-1327. Vonsover A, Leventon- Kriss S, Langer A, Smetana Z

  14. 带状疱疹分期针灸治疗体会%Acupuncture Therapy of Herpes Zoster on Different Stages

    Institute of Scientific and Technical Information of China (English)

    刘福华

    2012-01-01

    针灸治疗带状疱疹的疗效确切、方法多样,但缺乏对不同时期采用何种针灸方法对提高本病疗效的认识,文章就不同时期带状疱疹针灸治疗做以初步探讨,以期为临床选用方便、合理、有效治疗方案提供参考.%Acupuncture treatment of herpes zoster has definite effect, and methods are various, but the lack of different time.a of the types of acupuncture and moxibustion methods to improve the curative effect of understanding, the author according to different period shingles provide different acupuncture treatment to make the preliminary discussion, so as that convenient, reasonable and effective treatment can be chosen in clinical for reference.

  15. Parsonage-Turner Syndrome rather than Zoster Neuritis

    Directory of Open Access Journals (Sweden)

    Karim Gariani

    2011-07-01

    Full Text Available We report the case of an 86-year-old man with acute left shoulder pain, followed by left limb monoparesis and a herpetic rash on the left upper limb and thoracic region. This situation presented a diagnostic challenge because of the simultaneity of symptoms attributable to Parsonage-Turner syndrome and herpes zoster neuropathy. A detailed clinical history, physical examination and electroneuromyography were essential to distinguish the neurological structures involved and to ascertain the diagnosis.

  16. Synergistic activity of amenamevir (ASP2151) with nucleoside analogs against herpes simplex virus types 1 and 2 and varicella-zoster virus.

    Science.gov (United States)

    Chono, Koji; Katsumata, Kiyomitsu; Suzuki, Hiroshi; Shiraki, Kimiyasu

    2013-02-01

    ASP2151 (amenamevir) is a helicase-primase complex inhibitor with antiviral activity against herpes simplex virus HSV-1, HSV-2, and varicella-zoster virus (VZV). To assess combination therapy of ASP2151 with existing antiherpes agents against HSV-1, HSV-2, and VZV, we conducted in vitro and in vivo studies of two-drug combinations. The combination activity effect of ASP2151 with nucleoside analogs acyclovir (ACV), penciclovir (PCV), or vidarabine (VDB) was tested via plaque-reduction assay and MTS assay, and the data were analyzed using isobolograms and response surface modeling. In vivo combination therapy of ASP2151 with valaciclovir (VACV) was studied in an HSV-1-infected zosteriform spread mouse model. The antiviral activity of ASP2151 combined with ACV and PCV against ACV-susceptible HSV-1, HSV-2, and VZV showed a statistically significant synergistic effect (P<0.05). ASP2151 with VDB was observed to have additive effects against ACV-susceptible HSV-2 and synergistic effects against VZV. In the mouse model of zosteriform spread, the inhibition of disease progression via combination therapy was more potent than that of either drugs as monotherapy (P<0.05). These results indicate that the combination therapies of ASP2151 with ACV and PCV have synergistic antiherpes effects against HSV and VZV infections and may be feasible in case of severe disease, such as herpes encephalitis or in patients with immunosuppression.

  17. Analysis of the combined effect of local UV and acyclovir on herpes zoster%局部紫外线联合阿昔洛韦治疗带状疱疹的疗效观察

    Institute of Scientific and Technical Information of China (English)

    李智忠

    2010-01-01

    目的 观察局部紫外线照射联合阿昔洛韦治疗带状疱疹的临床疗效.方法 138例带状疱疹患者分为2组.治疗组用阿昔洛韦口服治疗加局部紫外线照射;对照组单用阿昔洛韦治疗带状疱疹.结果 治疗组有效率(97.92%)明显高于对照组(P<0.05),带状疱疹后遗神经痛发生率亦比对照组明显降低.结论 局部紫外线联合阿昔洛韦治疗带状疱疹起效快,疗程短,疗效显著,且能防止后神经痛的发生.%Objective To understand partial response of herpes zoster to ultraviolet radiation,and find other methods of herpes zoster treatment.Methods 138 cases of herpes zoster were divided into two groups.The treatment group received oral acyclovir and local ultraviolet irradiation while the control group received acyclovir alone.Results Treatment efficacy was significantly higher in the treatment group(97.92%)compared to the control( P < 0.05),and the incidence of postherpetic neuralgia was also significantly lower in the treatment group.Conclusion Local UV combined with acyclovir treatment of herpes zoster produces fast,brief duration,significant effects,and can prevent the occurrence of postherpetic neuralgia.

  18. Effect of Xinhuang Tablets on Herpes Zoster of the Earlier Period Neuralgia%新癀片治疗带状疱疹早期神经痛的序贯试验

    Institute of Scientific and Technical Information of China (English)

    徐翔; 梁东辉; 马红利

    2011-01-01

    目的 观察新癀片治疗带状疱疹早期神经痛的疗效和安全性.方法 采用质反应开放型单向序贯试验,逐对纳入基线资料相当的带状疱疹患者,按照既定随机分配方案接受不同的治疗计划.每对患者均接受抗病毒治疗和氦氖激光治疗,其中一位患者同时予新癀片1.28g,po tid.结果 当观察到第15对符合纳入标准的病例时,实验线触及U线,表明新癀片对带状疱疹神经痛止痛有效,不良反应少.结论 新癀片治疗带状疱疹早期神经痛的疗效肯定,安全性好.%Objective:To observe the curative effect and safety of xinhuang tablets on herpes zoster of the earlier period neuralgia. Method: A sequential test of the open single-direction qualitative reaction was adopted, and patients with herpes zoster and similar characteristics at baseline were randomly divided into two groups for different therapy. Both groups received the anti-viral and He-Ne laser therapy, but the treatment group took xinhuang tablets. Result;Up to the 15 pairs observed, the experimental line met with U line. It showed that xinhuang tablets had effect with little adverse reactions on the pain of herpes zoster neuralgia. Conclusion: Xinhuang tablets were safe and effective on herpes zoster of earlier period neuralgia.

  19. Exploration on the Mechanism of Recurrent Herpes Zoster in Patients with AIDS%艾滋病患者带状疱疹反复发作的机制探讨

    Institute of Scientific and Technical Information of China (English)

    郭会军; 付涵

    2012-01-01

    Objective: To investigate the mechanisms of multiple recurrent herpes zoster in AIDS patients. Methods: Scientific research achievements made by the domestic and foreign scholars in recent years in the mechanism of multiple recurrent herpes zoster in AIDS patients were summarized and analyzed combined with clinical observations. Results: Compared with the normal people, T-lymphocyte subsets(CD3 +, CD4+, CD8 + ) and CD4 +/CD8 + ratio of the patients with herpes zoster caused by VZV decreased, amone which T-helper cells decreased significantly and the ration of T helper cells and T suppressor cell( CD4 +/CD8+) decreased significantly. Conclusion; The suscepatibility of AIDS patients to get herpes zoster are related with hypoimmunity.%目的:探讨艾滋病患者多次复发带状疱疹的机制.方法:结合临床观察,总结分析近年来国内外学者关于艾滋病患者多次复发带状疱疹机制的科研成果.结果:由水痘-带状疱疹病毒(VZV)引起的带状疱疹患者的T淋巴细胞亚群(CD3+、CD4+、CDs+)以及CD4+ /CD8+比值与正常人比较均降低,其中T辅助细胞(CD4+)明显下降,T辅助细胞与T抑制细胞的比值(CD4 +/CD8+)明显降低.结论:艾滋病患者易发生带状疱疹与免疫力低下有关.

  20. Assessment and management of patients with acute red eye.

    Science.gov (United States)

    Watkinson, Sue

    2013-06-01

    This article provides an overview of the role of the nurse in the assessment and management of five ocular conditions that give rise to an acute red eye in older people. The conditions discussed are acute closed angle glaucoma, acute iritis, acute conjunctivitis, herpes zoster ophthalmicus and bacterial corneal ulcer.

  1. Herpes Zoster Oticus

    Science.gov (United States)

    ... permanent. Vertigo may last for days or weeks. Facial paralysis may be temporary or permanent. × Prognosis Generally, the ... permanent. Vertigo may last for days or weeks. Facial paralysis may be temporary or permanent. View Full Prognosis ...

  2. The Therapeutic Effect of Tapped Cupping with Laser Exposure Therapy in the Treatment of Herpes Zoster: An Analysis of 36 Cases%叩刺拔罐配合激光照射治疗带状疱疹36例

    Institute of Scientific and Technical Information of China (English)

    何祖书

    2011-01-01

    Objective:To observe the clinical therapeutic effect of tapped cupping with laser exposure therapy in the treatment of herpes zoster. Method:66 cases of herpes zoster were selected and divided randomly into treatment group(36 cases)and control group(30 cases). The treatment group was treated with tapped cupping and laser exposure therapy while the control was treated with laser exposure. They were treated for 7 days. Result: The effect of the treatment group was better than that in the control group (P <0. 05). Conclusion: The tapped cupping with laser exposure therapy in the treatment of herpes zoster is superior to laser exposure.%目的:观察叩刺拔罐配合激光照射治疗带状疱疹的临床疗效.方法:选取确诊带状疱疹的66例患者,随机分为治疗组36例与对照组30例.治疗组采用叩刺拔罐配合激光照射,对照组采用激光照射治疗.治疗7天观察疗效.结果:治疗组疗效明显优于对照组(P<0.05).结论:叩刺拔罐配合激光照射治疗带状疱疹疗效显著,优于单纯激光照射.

  3. Clinical curative effect observation of traditional Chinese medicine in the treatment of herpes zoster in 60 cases%中药治疗带状疱疹60例临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    主父晨星

    2016-01-01

    目的:探究中药治疗带状疱疹的临床疗效。方法:60例带状疱疹患者均采用银翘苦参汤治疗,观察患者的治疗有效率以及不良反应的发生情况。结果:治疗总有效率96.7%,不良反应3例(5.0%)。结论:中药治疗带状疱疹具有较好的临床效果,并发症较少。%Objective:To explore the traditional Chinese medicine in the treatment of herpes zoster.Methods:60 patients with herpes zoster were given Yin Qiao Ku Shen decoction treatment.The treatment effective rate and occurrence of adverse reactions of patients were observed.Results:The treatment effective rate was 96.7%.The adverse reactions were 3 cases(5.0%).Conclusion:Traditional Chinese medicine in the treatment of herpes zoster has a good clinical effect.The complication is less.

  4. 针灸治疗带状疱疹及其后遗神经痛60例%Acupuncture Treating 60 Cases of Herpes Zoster and Postherpetic Neuralgia

    Institute of Scientific and Technical Information of China (English)

    陈大翠

    2014-01-01

    目的:观察针灸治疗带状疱疹及其后遗神经痛的疗效。方法:60例患者均根据其带状疱疹期和后遗症期及中医辨证分型,选择合适针法治疗,观察其临床疗效。结果:治愈58例,好转2例,治愈率为96.7%。结论:针灸具有显著的活血、通络、止痛作用,合理选择应用是治疗带状疱疹及其后遗神经痛的有效方法。%Objective:To observe the curative effect of acupuncture treating herpes zoster and postherpetic neuralgia. Methods:60 patients chose ap-propriate acupuncture treatment according to the period of herpes zoster, sequelae period and syndrome differentiation of Chinese medicine, the clini-cal effect was observed. Results: 58 cases were cured, 2 cases improved, the cured rate was 96.7%. Conclusion:Acupuncture can invigorate the blood circulation, dredge collaterals and relieve pain, which reasonably applied is an effective method for herpes zoster and postherpetic neuralgia.

  5. Nursing Experience for 38 Cases Patients with Senile Herpes Zoster%38例老年头面部带状疱疹(蛇盘疮)病人的整体护理

    Institute of Scientific and Technical Information of China (English)

    徐琳

    2011-01-01

    目的:探讨老年头面部带状疱疹护理经验,以减少并发症,提高护理质量.方法:对本院住院的38例老年性头面部带状疱疹患者的护理进行分析总结.结果:经过正确有效的治疗和综合护理,38例患者均明显好转出院,无1例出现后遗神经痛.结论:有效的治疗配合多方面的综合护理可以减轻带状疱疹患者的疼痛、减少并发症.%Objective: To observe the nursing experience for senile herpes zoster to reduce complications and improve the quality of rursing.Methods: Analyzed the nursing experience of 38 cases of senile Herpes Zoster.Results: After effective treatment and nursing, none of 38 cases of senive Herpes Zoster were postherpetic neuralgia.Conclusion: Effective treatment and nursing can reliere the pain and reduce the complications.

  6. Clinical Observation of Rehabilitation Therapy in Treating Herpes Zoster Complicated by Motor Dysfunction%康复疗法治疗带状疱疹并发运动功能障碍临床观察

    Institute of Scientific and Technical Information of China (English)

    万勇; 刘洁; 周琦; 肖林; 陈启明; 陕大艳

    2014-01-01

    To observe the clinical curative effect of rehabilitation therapy in treating herpes zoster complicated by motor dys-function. Methods:5 patients with herpes zoster complicated by movement disorders were given physical therapy,movement and learn-ing,functional training such as individualized rehabilitation. Results:Patients′ muscle strength and limb function were improved marked-ly after 3 months treatment,follow-up for 1 a,with muscle strength gradually increasing. Conclusion:Individualized rehabilitation in trea-ting herpes zoster complicated by motor dysfunction can obviously improve patients′ motor function.%目的:观察康复疗法治疗带状疱疹并发的临床疗效。方法:5例带状疱疹并发肢体运动障碍患者,给予物理治疗、运动再学习,功能训练等个体化康复治疗。结果:治疗3个月后,患者肌力、肢体功能较治疗前明显好转,随访1 a,患者肌力逐步提高。结论:针对带状疱疹并发肢体运动功能障碍给予个性化康复治疗能明显提高患者运动功能。

  7. Report of 1 case of varicose veins of lower extremities with herpes zoster and lumbar disc protrusion%下肢浅静脉曲张伴带状疱疹及腰椎间盘突出1例

    Institute of Scientific and Technical Information of China (English)

    罗在胜; 吴志宏; 张加满

    2015-01-01

    In this paper, the diagnosis and treatment of 1 case for the simple varicose veins of lower extremities with herpes zoster and lumbar disc protrusion in patients was reviewed and summarized. The causes for missing diagnosis of herpes zoster in the early period were analyzed, in order to improve the recognition and identification of three types of diseases, including simple varicose veins of lower extremities, herpes zoster and lumbar disc protrusion. This will avoid missed diagnosis and misdiagnosis in the future clinical work.%通过对1例单纯性下肢浅静脉曲张溃疡形成伴带状疱疹及腰椎间盘突出患者的诊疗过程进行回顾、总结,分析早期对带状疱疹漏诊的原因,旨在提高对单纯性下肢浅静脉曲张、带状疱疹、腰椎间盘突出三种疾病的认识及鉴别,避免在今后的临床工作中出现漏诊及误诊。

  8. Herpes labialis in patients with Russell's viper bite and acute kidney injury: a single center experience.

    Science.gov (United States)

    Waikhom, Rajesh; Sapam, Ranjeeta; Patil, Krishna; Jadhav, Jaya Prada; Sircar, Dipankar; Roychowdhury, Arpita; Dasgupta, Sanjay; Pandey, Rajendra

    2011-06-01

    Snake bite is an important health hazard in tropical countries and is associated with significant morbidity and mortality. Herpes labialis is a common ailment caused by the Herpes simplex virus. There is no published data showing any association between the snake bite and development of Herpes labialis. Here, we present a series of patients who developed Herpes labialis after Russell's viper bite and had acute kidney injury. We attempted to find whether snake bite is an immunosuppressed state and whether it could have pre-disposed the patients to the development of these lesions.

  9. 早期足量抗病毒治疗带状疱疹临床疗效观察%Clinical observation on treatment of herpes zoster with high-dose antiviral therapy at early stage

    Institute of Scientific and Technical Information of China (English)

    彭光玲; 李惠

    2013-01-01

    目的:对比在治疗带状疱疹时早期足量使用阿昔洛韦类抗病毒药物与常规剂量治疗的病例在临床上的疗效.方法:以我科从2011年6月至2012年2月收治的带状疱疹患者为研究来源.以患者自愿为原则,对比分析观察组患者与对照组患者治疗结束后的临床疗效与带状疱疹后遗神经痛(postherpetic neuragia,PHN)的发生率.结果:对比观察治疗带状疱疹在疼痛缓解时间、止庖时间、皮损开始结痂时间、50%皮损结痂时间、皮损消失时间等各方面上,观察组明显短于两组对照组,差异具有统计学意义(P<0.05),但带状疱疹PHN的发生率及疼痛程度治疗后1、2、3、6月观察组与对照组其结果并无差异.对照组A与对照组B因无可比性,故未做对比.结论:对带状疱疹治疗,早期足量使用抗病毒药物其治疗效果显著,应当在临床上提倡,但对于是否可以减少带状疱疹PHN的发生及减缓其疼痛程度需要更进一步的临床研究.%Objective:To compare the clinical effect of herpes zoster(HZ) treated by routine dose and high-dose valacyclovir(VCV) classical antiviral drugs. Methods: Research source comes from the patients with herpes zoster admitted to our department from June 2011 to February 2012. Based on the principle of voluntary, patients with onset time 5 d were treated by high-dose antiviral therapy(control group B). Clinical effects and incidences of postherpetic neuralgia (PHN) of herpes zoster in the three groups at the end of treatment were compared and analyzed. Results:Pain relieving time,cessation time of new lesion,beginning time of skin lesion crusting,50% lesion crusting time and subsiding time of skin lesions were significantly shorter in observation group than in control groups (A and B) during the treatment of herpes zoster, with statistical significances (P<0.05). There was no significant difference in incidences and pain degrees of PHN of herpes zoster within the first

  10. 整体护理干预对带状疱疹患者的影响分析%Analysis of the Effects of Holistic Nursing Intervention in Patients with Herpes Zoster

    Institute of Scientific and Technical Information of China (English)

    张玉荣

    2014-01-01

    Objective To explore the effects of holistic nursing intervention in patients with herpes zoster. Methods 65 cases of herpes zoster patients in our hospital from 2011 July to 2013 October were selected,and al patients were randomly divided into nursing intervention group 33 cases and control group of 32 cases. Comparison of the clinical curative effect and the symptoms of two patients healed herpes were al observed. Results Nursing intervention group patients,the total effective rate was 93.94%,significantly higher than that in control group 81.35%, two groups,significant difference(P<0.05). A blister,pain,scar and herpes healing nursing intervention group were significantly lower than those in the control group,the two groups,the difference was statistical y significant(P<0.05). Conclusion Holistic nursing intervention on patients with herpes zoster can significantly improve the clinical efficacy,improve the clinical symptoms and the healing of herpes zoster.%目的:探讨对带状疱疹患者实施整体护理干预的影响效果。方法选取65例于2011年7月~2013年10月在本院就治的带状疱疹患者,按照随机数字表法把所有患者随机分为护理干预组33例及对照组32例。对两组患者的临床疗效及患者症状、疱疹愈合情况进行比较。结果护理干预组患者的总有效率为93.94%,明显高于对照组的81.35%,两组比较,差异显著(P<0.05)。护理干预组的止疱、止痛、结痂及疱疹愈合时间均显著低于对照组,两组比较,差异有统计学意义(P<0.05)。结论对带状疱疹患者进行整体护理干预可明显提高其临床疗效,明显改善患者的临床症状及疱疹愈合情况。

  11. 社区老年人带状疱疹综合治疗46例疗效观察%Observation of comprehensive treatment of 46 cases ofsenile people with herpes zoster in community

    Institute of Scientific and Technical Information of China (English)

    王艳红

    2013-01-01

    目的:探讨应用综合方法治疗带状疱疹的疗效。方法:选择90例≥60岁的带状疱疹病例,随机分为综合治疗组46例和局部治疗组44例。综合治疗组采用局部及全身疗法,局部治疗组仅采用单纯局部治疗。结果:综合治疗组的疱疹结痂时间、疼痛缓解程度明显优于局部治疗组、差异有统计学意义(P<0.05)。结论:应用全身抗病毒、营养神经以及局部治疗的综合方法治疗带状疱疹疗效显著。%Objective:To investigate the efficacy of application of an integrated approach to the treatment of her-pes zoster. Methods:90 patients aged 60 and over herpes zoster cases, and the cases were randomly divided into a combined therapy group of 46 patients and topical treatment group of 44 patients. The combined therapy group use topical treatment and systemic therapy,and topical treatment group use only local therapy alone.Results:The combined therapy group have much better effect than the topical treatment group in herpes scab, pain relief. The difference was statistically significant (P<0.05). Conclusion: The comprehensive method of systemic application of antiviral, neu-rotrophic and local treatment is significantly effective in treatment of herpes zoster.

  12. Clinical observation on treating 15 cases of herpes zoster in TCM%中药治疗带状疱疹15例临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    吴雄鹰

    2012-01-01

      目的:探讨由中药治疗带状疱疹的临床疗效.方法:对15例带状疱疹患者采用中药外敷兼内服治疗,并与西医常规治疗对照观察.结果:中药治疗组临床治愈率(40.0%)总有效率(93.3%)均明显高于西医常规治疗组(P<0.05).结论:中药治疗带状疱疹具有实用推广价值.%  Objective:To study the clinical effect of treating herpes zoster in TCM. Methods:15 cases of patients with herpes zoster were given TCM topical and oral for treatment, and compare observe the routine modern medicine. Results:In the TCM group, the clinical cure rate of the treatment group (40.0%) of the total efficiency (93.3%) were significantly higher than than in the modern conventional treatment group (P<0.05). Conclusion:Treating zoster in TCM has practical application value.

  13. Development of a multiplex real-time PCR for the simultaneous detection of herpes simplex and varicella zoster viruses in cerebrospinal fluid and lesion swab specimens.

    Science.gov (United States)

    Wong, Anita A; Pabbaraju, Kanti; Wong, Sallene; Tellier, Raymond

    2016-03-01

    Herpes simplex viruses (HSV) and varicella zoster virus (VZV) can have very similar and wide-ranging clinical presentations. Rapid identification is necessary for timely antiviral therapy, especially with infections involving the central nervous system, neonates, and immunocompromised individuals. Detection of HSV-1, HSV-2 and VZV was combined into one real-time PCR reaction utilizing hydrolysis probes. The assay was validated on the LightCycler(®) (Roche) and Applied Biosystems 7500 Real-Time PCR System (Thermo Fisher Scientific Inc.) to detect alphaherpesviruses in cerebral spinal fluid (CSF) and lesion swab specimens, respectively. Validation data on blood and tissue samples are also presented. The multiplex assay showed excellent sensitivity, specificity and reproducibility when compared to two singleplex real-time PCR assays for CSF samples and direct fluorescent antigen/culture for lesion swab samples. Implementation of the multiplex assay has facilitated improved sensitivity and accuracy as well as reduced turn-around-times and costs. The results from a large data set of 16,622 prospective samples tested between August 16, 2012 to February 1, 2014 at the Provincial Laboratory for Public Health (Alberta, Canada) are presented here.

  14. 火针加火罐治疗带状疱疹66例临床分析%Clinical analysis on treating 66 cases of herpes zoster by fire needle combined with cupping

    Institute of Scientific and Technical Information of China (English)

    高作宏

    2013-01-01

    目的:探讨分析火针加火罐治疗带状疱疹的临床疗效。方法:回顾性分析2011年12月~2012年12月间在我社区中医科进行治疗的66例带状疱疹患者的临床记录资料。结果:治疗1周后,治疗组总有效率为97.06%,高于对照组的84.38%,具有显著性差异(P<0.05);治疗组的治愈时间和治疗费用均少于对照组,具有显著性差异(P<0.01)。结论:火针加火罐治疗带状疱疹的临床疗效显著,且操作简单,值得推广。%Objective:To investigate the clinical effect on treating herpes zoster by fire needle combined with cupping. Methods:Analysis the clinical data of 66 cases of herpes zoster patients from December 2011 to December 2012 in our community Chinese medical department. Results:A week after treatment, the total efficiency of treated group was 97.06%, higher than the 84.38%in the control group, with significant difference (P<0.05); the cure time and treatment costs were lower than the control group, with significant difference (P<0.01). Conclusion:Clinical therapeutic effect of fire needle combined with cupping therapy for herpes zoster significantly, and has the advantages of simple operation, worthy of promotion.

  15. THE LESIONS OF THE NERVOUS SYSTEM CAUSED BY THE VARICELLA-ZOSTER VIRUS IN CHILDREN

    Directory of Open Access Journals (Sweden)

    I. H. Belyaletdinova

    2016-01-01

    Full Text Available To describe the spectrum of neurological complications in children with varicella and against the background of herpes zoster. The study included children at the age of 0—16 years (n = 84, who recovered from exanthematous form of the disease not longer than 21 day before the appearance  of neurological symptoms (n = 82 or presented with herpes zoster (n = 2. Results: Clinical syndromes  included acute cerebellar ataxia (n = 37, meningoencephalitis (n = 34, meningitis (n = 7, polyradiculoneuropathy (n = 4, acute disseminated encephalomyelitis (n = 1, and ischemic stroke (n = 1. The period from varicella onset to the appearance of neurological symptoms was 6 [5;8] days. We have not lethal cases. Аcute cerebellar ataxia is most common  postvaricella complication  in children.

  16. 系统性红斑狼疮并发带状疱疹的相关危险因素分析%Analysis of related risk factors in patients with systemic lupus erythematosus complicated with herpes zoster

    Institute of Scientific and Technical Information of China (English)

    白云静; 申洪波; 陈竹; 姜德训; 安娜

    2015-01-01

    目的:探讨系统性红斑狼疮( systemic lupus erythematosus,SLE)并发带状疱疹( herpes zoster,HZ)的相关危险因素,指导临床预防和控制HZ的发生。方法选取于北京军区总医院住院的SLE并发HZ患者26例作为观察组,选取同期住院的SLE患者35例作为对照组,采用单因素分析和多因素非条件Logistic回归对两组患者进行比较分析。结果单因素分析显示:患者病程、淋巴细胞绝对值、激素治疗时间、激素冲击例数、免疫抑制剂治疗时间、1个月内环磷酰胺冲击与否以及T淋巴细胞亚群中分化簇抗原3阳性细胞(cluster of differentiation 3,CD+3)、分化簇抗原4阳性细胞(cluster of differentiation 4,CD+4)、分化簇抗原8阳性细胞(cluster of differentiation 8,CD+8)数值、CD+4/ CD+8比值等指标差异均有显著性(P<0.05)。多因素Logistic回归分析显示:激素治疗时间和激素冲击例数与并发HZ呈显著正相关,淋巴细胞绝对值与HZ呈显著负相关(P<0.05)。结论 SLE患者激素使用时间延长、激素冲击治疗以及淋巴细胞绝对值减少是HZ发生的主要危险因素;而患者的病程延长、免疫抑制剂治疗时间延长、1个月内环磷酰胺冲击治疗以及CD+3、CD+4数值下降、CD+8数值升高、CD+4/ CD+8比值下降等是次要的危险因素,临床医生应早期给予关注并积极预防HZ的发生。%Objective Exploring the related risk factors in patients with systemic lupus erythematosus complicated with herpes zoster,to prevent and control herpes zoster. Method Enrolled 26 cases of systemic lupus erythematosus patients with herpes zoster as the observation group from inpatients of Department of Rheumatism of General Hospital of Beijing Military Region,35 cases of systemic lupus erythematosus patients hospitalized in the same period as the control group. The clinical data of two groups of successively by single factor analysis and multi factor non condition-al Logistic

  17. Clinical treatment and nursing care of 50 patients with herpes zoster%50例带状疱疹患者的临床治疗及护理探讨

    Institute of Scientific and Technical Information of China (English)

    张萌萌

    2016-01-01

    Objective:To explore the treatment of herpes zoster associated with nursing care.Methods:Reviewed 50 cases of hospitalized patients experience treatment and care, the use of systemic therapy, topical and semiconductor laser treatment. Patients with different degrees and for different parts of herpes zoster,to reinforce pain care, psychological care, primary care, medication guide, diet care, health care and education rash and therapeutic effects were observed. Results:Treatment of patients with herpes zoster time is 7~13d, the average length of stay of not more than 10d, 50 patients were completely cured and no complication occurs,the treatment effect is remarkable. Conclusions:It is of great signiifcance to improve the therapeutic effect of herpes zoster by standard treatment methods,careful nursing measures and effective health education.%目的:探讨带状疱疹的治疗方法与相关护理措施。方法:回顾总结50例住院患者的治疗与护理经验,采用全身治疗、局部涂抹及半导体激光治疗方法,针对不同部位及不同程度带状疱疹的患者,进行加强疼痛护理、心理护理、基础护理、用药指导、饮食护理、皮疹护理及健康教育,并观察治疗效果。结果:带状疱疹患者的治疗时间为7~13d,平均住院日不超过10d,50例患者均完全治愈出院,且无并发症的现象发生,治疗效果显著。结论:规范正确的治疗方法、精心的护理措施及行之有效的出院健康教育对提高带状疱疹的治疗效果有重要意义。

  18. Pathogenic Relevant Factors Epidemiological Analysis of Postherpetic Neuralgia of Herpes Zoster%带状疱疹后遗神经痛发病相关因素流行病学分析

    Institute of Scientific and Technical Information of China (English)

    孔宇虹; 李元文; 杨碧莲; 蔡玲玲; 孙占学

    2014-01-01

    PHN of risk factors include:herpes zoster degree of acute pain (P=0. 002,OR=14. 507),diabetes melli-tus(P =0.007,OR =7.066)OR malignant tumors(P =0.007,OR =25.978),skin lesions type(χ2 =13. 377,P=0. 010), the precursor of pain occurred (P=0. 015,OR=5. 366), age (Z= -2. 442,P=0. 015), the lesion area (Z= -2. 203,P=0. 028). And sex, site and inducing factors and the occurrence of PHN has nothing to do. PHN reduced favorable factors include:the onset of treatment time to start ( P=0. 008, OR=9. 785) and early treatment method (χ2 =9. 535,P =0. 009). Conclusion Postherpetic neuralgia after herpes zoster occurred mostly related to the degree of acute pain, followed by the merger of diabetes, malignant tumor, early treatment, skin lesions type, precursor pain occurs, lesion area and so on, while sex, place, inducing factors was not associated with the occurrence of this disease Herpes zoster as soon as possible and Treatment with TCM independently or combined with little hormones in the early stage of PTN do good to prevent the happening of PHN.

  19. Use of lambdagt11 to isolate genes for two pseudorabies virus glycoproteins with homology to herpes simplex virus and varicella-zoster virus glycoproteins

    Energy Technology Data Exchange (ETDEWEB)

    Petrovskis, E.A.; Timmins, J.G.; Post, L.E.

    1986-10-01

    A library of pseudorabies virus (PRV) DNA fragments was constructed in the expression cloning vector lambdagt11. The library was screened with antisera which reacted with mixtures of PRV proteins to isolate recombinant bacteriophages expressing PRV proteins. By the nature of the lambdagt11 vector, the cloned proteins were expressed in Escherichia coli as ..beta..-galactosidase fusion proteins. The fusion proteins from 35 of these phages were purified and injected into mice to raise antisera. The antisera were screened by several different assays, including immunoprecipitation of (/sup 14/C)glucosamine-labeled PRV proteins. This method identified phages expressing three different PRV glycoproteins: the secreted glycoprotein, gX; gI; and a glycoprotein that had not been previously identified, which we designate gp63. The gp63 and gI genes map adjacent to each other in the small unique region of the PRV genome. The DNA sequence was determined for the region of the genome encoding gp63 and gI. It was found that gp63 has a region of homology with a herpes simplex virus type 1 (HSV-1) protein, encoded by US7, and also with varicella-zoster virus (VZV) gpIV. The gI protein sequence has a region of homology with HSV-1 gE and VZV gpI. It is concluded that PRV, HSV, and VZV all have a cluster of homologous glycoprotein genes in the small unique components of their genomes and that the organization of these genes is conserved.

  20. TO STUDY THE CLINICAL AND EPIDEMILOGICAL DATA OF HERPES ZOSTER AND ASSESS THE RELATION BETWEEN RISK FACTORS AND DEVELOPMENT OF POSTHERPETIC NEURALGIA (PHN

    Directory of Open Access Journals (Sweden)

    Atul

    2015-11-01

    Full Text Available BACKGROUND: Herpes zoster (HZ is a common viral disorder with characteristic rashes and pain. Postherpetic neuralgia (PHN is most common complication of HZ. There may be increased chances of PHN in the presence of various risk factors. AIM: To study the clinical and epidemiological data of HZ and assess the relation between risk factors and developement of PHN. MATERIAL AND METHODS: In this prospective study cases of HZ attending the outdoor of dermatology department were included irrespective of age and sex. Relevant demographic and clinical findings of all the cases were recorded in a predesigned performa. Cases were followed up for next 6 months for the development of any complication and recorded the same if occurred. Relevant risk factors in cases of PHN were observed, recorded and analysed. RESULTS: 123 cases were included in the study. Most common age group affected was 31-40 years, slightly more common in female sex and commonly occurred in immunocompromised cases. Most common dermatome affected was thoracic. PHN occurred in 23 (18.7% cases. About 61% of PHN cases were above the age of 50 years and it occurred in 45.45% cases of HZ with ophthalmic involvement. CONCLUSION: HZ is a common disease in the cases attending the dermatology OPD. PHN is most common complication which is more commonly associated with older age, female sex, presence of prodrome, severe rash and pain within 3 days and involvement of ophthalmic division of trigeminal nerve. But ther is no significant relation between occurrence of PHN and antiviral drug treatment.

  1. Síndrome do ápice orbitário causada por herpes zóster oftálmico: relato de caso e revisão da literatura Herpes zoster ophthalmicus and orbital apex syndrome: case report and literature review

    Directory of Open Access Journals (Sweden)

    Kenzo Hokazono

    2009-10-01

    Full Text Available OHerpes Zoster Oftálmico (HZO decorre da infecção pelo vírus da varicela-zoster que permanece latente no gânglio de Gasser até que seja reativado e comprometa a divisão oftálmica do nervo trigêmeo. HZO freqüentemente causa manifestações oftalmológicas como lesões vesiculares palpebrais, ceratoconjuntivite, esclerite, uveíte, paralisia oculomotora, miosite orbitária e neurite óptica. Raramente o acometimento do ápice da órbita pode ser a manifestação inicial desta grave afecção. Este trabalho relata um caso de síndrome do ápice orbitário associado à meningite, causado por HZO e que foi tratado com corticosteróide e aciclovir sistêmicos.Herpes Zoster ophthalmicus (HZO is caused by a varicella-zoster virus infection which remains latent in the ganglion of Gasser until it is reactivated and compromise the ophthalmic division of the trigeminal nerve. HZO commonly causes neuro-ophthalmic complications such as vesicular lesions in the eyelids, keratoconjunctivitis, sclertis, uveitis, ocular palsy, orbital miositis and optic neuritis. HZO rarely presents as an orbital apex syndrome. This paper describes a patient with of orbital apex syndrome associate and meningitis caused by HZO which was treated with systemic steroids and acyclovir.

  2. Influence of pain nursing intervention on quality of life of mid aged and old patients with herpes zoster%疼痛干预对中老年带状疱疹病人生活质量的影响

    Institute of Scientific and Technical Information of China (English)

    吴娜; 许青; 丁艳

    2015-01-01

    Objective:To probe into the influence of pain nursing intervention on quality of life of mid aged and old patients with herpes zoster.Methods:A total of 66 patients with herpes zoster were randomly divided into in-tervention group and control group.They were analyzed by using the revised facial pain scale (FPS R),self e-valuation of anxiety scale (SAS),the sleep status since the rating scale (SRSS),dermatology life quality index questionnaire (DLQI)before the pain nursing intervention,at 7 days after treatment and at a week after dis-charge.Results:After pain nursing intervention,the scores of SAS,SRSS,FPS R,DLQI in the intervention group were significantly lower than that in control group (P < 0.05).The quality of life in intervention group was better than that in control group after pain nursing intervention.Conclusion:Pain nursing intervention could effectively relieve the pain of herpes zoster patients,improve their psychological state,improve their sleep quali-ty and enhance their quality of life.%[目的]探讨疼痛干预对中老年带状疱疹病人生活质量的影响。[方法]选择66例中老年带状疱疹病人,随机分为干预组和对照组,于疼痛护理干预前、治疗7 d 后、出院1周后,采用修订版面部表情疼痛量表(FPS R)、焦虑自评量表(SAS)、睡眠状况自评量表(SRSS)、皮肤病生活质量指标调查表(DLQI),对其进行调查分析。[结果]干预后干预组 FPS R、SAS、SRSS、DLQI 评分均明显低于对照组(P <0.05),干预后干预组生活质量优于对照组。[结论]疼痛干预可有效缓解带状疱疹病人疼痛,改善心理状态,提高睡眠质量,提升生活质量。

  3. 电针联合刺络拔罐治疗带状疱疹疗效观察%Observation on clinical effect of electroacupuncture plus pricking-cupping bloodletting therapy for herpes zoster

    Institute of Scientific and Technical Information of China (English)

    华宇; 李瑛; 郭清; 季玲琳; 王剑波

    2015-01-01

    目的:观察电针配合刺络拔罐治疗带状疱疹的临床疗效。方法:将43例带状疱疹患者随机分为治疗组23例和对照组20例。治疗组采用电针联合刺络拔罐治疗;对照组采用口服阿昔洛韦片(Aciclovir Tablets)、双氯芬酸钠双释放肠溶胶囊(Diclofenac Sodium Dual Release Enteric-coated Capsules)、甲钴胺分散片(Methylcobalamin Dispersible Tablets)、维生素B12治疗。结果:治疗组总有效率为87.0%,对照组为70.0%,两组总有效率差异有统计学意义(P<0.01)。结论:电针联合刺络拔罐治疗带状疱疹的临床疗效优于药物治疗。%Objective:To observe the clinical effect of electroacupuncture (EA) plus pricking-cupping bloodletting therapy for herpes zoster. Methods:A total of 43 patients with herpes zoster were randomly divided into two groups, 23 cases in the treatment group and 20 cases in the control group. The treatment group was given EA plus pricking-cupping bloodletting therapy. The control group was given oral administration of Aciclovir Tablets, Diclofenac Sodium Dual Release Enteric-coated Capsules, Methylcobalamin Dispersible Tablets, and V itamin B12. Results: The total effective rate was 87.0% in the treatment group and 70.0% in the control group, with a statistical significance in difference of the total effective rate between the two groups (P Conclusion:The clinical effect is better in the treatment of herpes zoster by EA plus pricking-cupping bloodletting therapy than by medications.

  4. 火针刀与火针治疗带状疱疹的疗效比较%Efficacy Comparison of Herpes Zoster Treatments with Cauterized Needle-Knife and Cauterized Needle

    Institute of Scientific and Technical Information of China (English)

    唐胜修; 王小莲; 刘辛; 韦春华

    2011-01-01

    Objective: To compare the herpes zoster treatment efficacy of cauterized needle-knife and cauterized needle.Methods: 43 cases of herpes zoster patients were divided into 2 groups according with random number table method, 23 cases of cauterized needle-knife group ( group 1 ) and 20 cases of cauterized needle group ( group 2 ).After the 2 groups were treated respectively, add up the whole scab time and changes in pain intensity of the 2 groups respectively, then make statistical comparison.Results:After treatments, the whole scab time of group 1 was significantly lower than that of group 2 ( P<0.05 ), the pain score of group 1 was significantly lower than that of group 2 ( P<0.05 ), and after treatment, the pain score in group 1 was significantly less than the pre-treatment score.Conclusion: The herpes zoster treatment efficacy of cauterized needle-knife was superior to that of the cauterized needle.%目的:比较火针刀与火针治疗带状疱疹的疗效.方法:带状疱疹患者43例,按随机数字表法分为火针刀组23例和火针组20例,火针刀组以火针刀治疗,火针组以火针治疗,然后分别统计两组的全部结痂时间和疼痛强度变化,并加以比较.结果:火针刀组全部结痂时间明显少于火针组(P<0.05),治疗后火针刀组疼痛强度评分明显少于火针组(P<0.05),火针刀组治疗后疼痛强度评分明显少于治疗前评分(P<0.05).结论:火针刀治疗带状疱疹疗效优于火针治疗.

  5. Clinical observation of combination of Chinese and western medicine in treatment of herpes zoster%中西医结合治疗带状疱疹临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    刘勤

    2014-01-01

    Objective To observe the therapeutic effect of combination of Chinese and Western in the treatment of her-pes zoster. Methods A total of 64 cases of herpes zoster patients in our hospital from 2012 October to 2014 January were randomly divided into treatment group and control group with 32 cases in each group.Two groups were given In-travenous ganciclovir,Mecobalamin Tablets oral and Polyinosinic injection. The treatment group was given for herpes skin needle tapping and cupping with Aciclovir ointment coating.The control group was treated with Aciclovir ointment. Two groups of patients with herpes scab and pain subsided, recovery and adverse reactions were observed in the contin-uous treatment for 10 days. Results The total effective rate of treatment group was significantly higher than the control group after treatment, the differences were statistically significant (P<0.05).The herpes subsided, scab and pain recovery time were shorter than the control group, there were statistically significant (P<0.05). Conclusion Treatment of herpes zoster with integrated traditional Chinese and western medicine curative effect, fast acting, can greatly improve the comfort of patients, enhance the quality of life, and simple and easy operation, economic benefits, it is the primary hos-pital clinical use.%目的:探讨中西医结合治疗带状疱疹的临床疗效。方法选取我院2012年10月~2014年1月收治的64例带状疱疹患者,随机分为治疗组和对照组各32例。两组均常规予更昔洛韦静滴,甲钴胺片口服,聚肌胞肌注;对于疱疹处的处理,治疗组予皮肤针叩刺后拔罐以阿昔洛韦乳膏外涂,对照组仅予阿昔洛韦乳膏外涂。连续治疗10 d,观察两组患者疱疹的消退、结痂、疼痛恢复情况以及不良反应。结果两组患者治疗后,治疗组总有效率明显高于对照组,两组比较有统计学意义(P<0.05),且治疗组患者疱疹的消退、结痂及疼痛恢复时间

  6. 蛇药片外用治疗皮肤型带状疱疹体会%Experience of snake tablet topical treated on skin type of herpes zoster

    Institute of Scientific and Technical Information of China (English)

    金旭园

    2015-01-01

    目的:探讨蛇药外用治疗带状疱疹的效果。方法:10例取季德胜蛇药片研细末加适量75%酒精,在患者水疱红斑处进行外敷治疗。结果:经过治疗和护理均获得临床治愈,无一例无效,总有效率100%。结论:采用蛇药加75%酒精外敷方法具有清热解毒、消肿止痛的功效,同时起效快,操作简便,价格便宜,使用安全,能及早减轻患者痛苦和恢复正常生活等优点,患者易于接受。%Objective:To investigate the effect of snake tablet topical treated on skin type of herpes zoster.Methods:10 paitents with skin type of herpes zoster were selected.Ji Desheng snake tablets grind into fine powder with the appropriate amount of 75%alcohol were used for external application on vesicular erythema of patients.Results:After the treatment and nursing care all the patients were cured,and the total efficiency was 100%.Conclusion:Snake tables combineded with 75% alcohol used for external application has effect of heat clearing and detoxicating,swelling and alleviate pain.It also has the adavantages of fast,simple,cheap and safe.It can alleviate the pain of patients and the advantages of early return to normal life,so the patient has good compliance.

  7. Clinical Analysis of Eight Cases AIDS Presented with Herpes Zoster as the Initial Symptom%以带状疱疹为首发症状的艾滋病8例临床分析

    Institute of Scientific and Technical Information of China (English)

    郭强; 黎宝励

    2012-01-01

    Objective To profile characteristics and relationships of patients with AIDS combined with venereal diseases, various skin diseases, prostitution, history of multiple sex partners and has first symptom of herpes zoster. Methods Analyze clinical data of 8 patients with AIDS whose first symptom was herpes zoster, diagnosed and treated during the period from March 2011 and February 2012. Results Among the 8 patients, there are 3 males and 5 females, 7 cases were aged between 26 and 38, and ! case was aged 81 ; 5 cases were unmarried and widowed, and 3 cases were married. 8 cases were generally in a good condition, 7 cases had herpes zoster on four limbs of their body, and 1 case had herpes zoster on the face. Skin lesions were large areas of clusters of blisters, bulla and blood blister, part of which was combined with severe tingling. 2 cases had non-gonoeoc-cal urethritis (cervical) inflammation, 1 case had gonorrhea, I case had condyloma, 1 case had latent syphilis, and 1 case had combined recurrent genital herpes and advanced tuberculosis. At the same time, 1 case had combined herpes simplex and seborrheic dermatitis; and 1 case had condyloma, non-gonococcal cervicitis and latent syphilis. 8 patients have hislory of multiple sexual partners or prostitution, without history of blood transfusion and drug abuse. 7 cases were cured after treatment, while 1 case had poslherpetic neuralgia for 3 months. Conclusion Patients with herpes zoster, with lower level of education, unmarried, history of multiple sexual partners, history of prostitution, history of venereal diseases in the past and at present, or various recurrent skin diseases and tuberculosis, especially young females in service industry and people who are sexually active should have HIV screening examination to avoid missed diagnosis.%目的 探讨合并有性病、多种皮肤病、嫖娼、多性伴史与以带状疱疹为首发表现的艾滋病患者的特点和关系 方法 对2011年3月-2012年2

  8. Pupilparalyse. En sjaelden komplikation ved øjeninfektion med Varicella zoster-virus

    DEFF Research Database (Denmark)

    Hallas, P

    2001-01-01

    Pupillary paralysis and paresis of the peripheral facial nerve on the left side was found in a 68-year-old man with concussion and herpes zoster ophthalmicus on the left eye. Post mortem examination showed no sign of intracranial hemorrhage. The cause of death was pulmonary oedema and aspiration....... The neurological signs were probably caused by herpes zoster affection of the oculomotor and optic nerves in association with the facial nerve paresis induced by zoster....

  9. 带状疱疹性角膜炎采用阿昔洛韦联合玻璃酸钠及氟米龙眼液治疗的临床体会%The Clinical Experience of Acyclovir Combined With Sodium Hyaluronate and Fluorometholone Eye Drops in Treatment of Herpes Zoster Keratitis

    Institute of Scientific and Technical Information of China (English)

    赵艳辉

    2015-01-01

    目的:对带状疱疹性角膜炎采用阿昔洛韦联合玻璃酸钠及氟米龙眼液治疗的临床效果进行研究分析。方法选取我院收治的带状疱疹性角膜炎患者进行临床研究。结果治疗组总有效率90.00%、畏光消失时间(8.02±3.11)min,荧光素染色阴性时间(12.13±3.02)min,同对照组患者的70.00%(、11.05±2.61)min和(15.47±2.38)min相比,P<0.05。结论阿昔洛韦联合玻璃酸钠及氟米龙眼液治疗带状疱疹性角膜炎疾病效果显著。%ObjectiveAnalysis the clinical effect of herpes zoster keratitis with acyclovir combined with sodium hyaluronate and fluorometholone eye drops in the treatment of Herpes zoster keratitis.Methods Selected patients with herpes zoster keratitis in our hospital.Results The total effective rate of treatment group reached to 90%, photophobia disappeared time (8.02 ± 3.11) min, lfuorescein staining negative time (12.13 ± 3.02) min with 70% of control patients, (11.05 ± 2.61) min and (15.47 ± 2.38) min,P<0.05.Conclusion Acyclovir combined with sodium hyaluronate and lfuorometholone eye drops in treatment of herpes zoster keratitis disease has clinically signiifcant.

  10. Varicella zoster virus reactivation during or immediately following treatment of tegumentary leishmaniasis with antimony compounds

    Directory of Open Access Journals (Sweden)

    Andrea Barbieri Barros

    2014-07-01

    Full Text Available Antimony compounds are the cornerstone treatments for tegumentary leishmaniasis. The reactivation of herpes virus is a side effect described in few reports. We conducted an observational study to describe the incidence of herpes zoster reactivation during treatment with antimony compounds. The global incidence of herpes zoster is approximately 2.5 cases per 1,000 persons per month (or 30 cases per 1,000 persons per year. The estimated incidence of herpes zoster in patients undergoing antimony therapy is higher than previously reported.

  11. Safety and effectiveness of the herpes zoster vaccine to prevent postherpetic neuralgia: 2014 Update and consensus statement from the Canadian Pain Society

    Directory of Open Access Journals (Sweden)

    Canadian Pain Society Study Day participants

    2015-01-01

    Full Text Available The Canadian Pain Society (CPS hosted its first Study Day in Toronto in July 2014, attended by experts in various fields of pain management and research (listed below. The aim was to review the National Advisory Committee on Immunization guidelines and to prepare a CPS position statement concerning the use of the zoster vaccine in Canada.

  12. Acute meningoencephalomyelitis due to varicella-zoster virus in an AIDS patient: report of a case and review of the literature

    Directory of Open Access Journals (Sweden)

    Marcelo Corti

    2011-12-01

    Full Text Available Varicella-zoster virus (VZV meningoencephalomyelitis is a rare but severe neurological complication of VZV reactivation in immunocompromised patients. We report the case of an HIV-infected individual who developed an acute and severe meningoencephalomyelitis accompanied by a disseminated cutaneous eruption due to VZV. The presence of VZV DNA in cerebrospinal fluid was confirmed by polymerase chain reaction (PCR technique. The patient started undergoing an intravenous acyclovir therapy with a mild recovery of neurological manifestations. Varicella-zoster virus should be included as a cause of acute meningoencephalomyelitis in patients with AIDS. Early diagnosis followed by specific therapy should modify the rapid and fulminant course for this kind of patients.

  13. Microbiology laboratory and the management of mother-child varicella-zoster virus infection

    Science.gov (United States)

    De Paschale, Massimo; Clerici, Pierangelo

    2016-01-01

    Varicella-zoster virus, which is responsible for varicella (chickenpox) and herpes zoster (shingles), is ubiquitous and causes an acute infection among children, especially those aged less than six years. As 90% of adults have had varicella in childhood, it is unusual to encounter an infected pregnant woman but, if the disease does appear, it can lead to complications for both the mother and fetus or newborn. The major maternal complications include pneumonia, which can lead to death if not treated. If the virus passes to the fetus, congenital varicella syndrome, neonatal varicella (particularly serious if maternal rash appears in the days immediately before or after childbirth) or herpes zoster in the early years of life may occur depending on the time of infection. A Microbiology laboratory can help in the diagnosis and management of mother-child infection at four main times: (1) when a pregnant woman has been exposed to varicella or herpes zoster, a prompt search for specific antibodies can determine whether she is susceptible to, or protected against infection; (2) when a pregnant woman develops clinical symptoms consistent with varicella, the diagnosis is usually clinical, but a laboratory can be crucial if the symptoms are doubtful or otherwise unclear (atypical patterns in immunocompromised subjects, patients with post-vaccination varicella, or subjects who have received immunoglobulins), or if there is a need for a differential diagnosis between varicella and other types of dermatoses with vesicle formation; (3) when a prenatal diagnosis of uterine infection is required in order to detect cases of congenital varicella syndrome after the onset of varicella in the mother; and (4) when the baby is born and it is necessary to confirm a diagnosis of varicella (and its complications), make a differential diagnosis between varicella and other diseases with similar symptoms, or confirm a causal relationship between maternal varicella and malformations in a newborn

  14. Clinical Efficacies of Helium Neon Laser Plus Pharmacotherapy in the Treatment of Herpes Zoster Patients%氦氖激光联合药物治疗带状疱疹的疗效观察

    Institute of Scientific and Technical Information of China (English)

    张碧红

    2015-01-01

    【目的】探讨氦氖激光联合药物治疗带状疱疹的临床疗效。【方法】98例带状疱疹患者随机分为两组,观察组50例和对照组48例 。两组患者均接受更昔洛韦、神经营养药和局部护理等治疗,观察组在此基础上采用氦氖激光治疗仪照射患处疼痛波及的区域,每天1次,每个部位10 min 。两组疗程均为7 d ,比较两组患者的疗效。【结果】观察组治愈39例,显效 9例,有效2例,无效 0例 ,总有效率为96.0%(48/50);对照组治愈26例,显效 9例,有效11例,无效2例,总有效率72.9%(37/48),观察组疗效优于对照组,且两组相比较差异有显著性(χ2=10.066,P < 0.01)。【结论】氦氖激光联合药物治疗带状疱疹的疗效显著,值得临床推广应用。%Objective] To explore the clinical effects of helium neon laser plus pharmacotherapy in the treatment of herpes zoster patients .[Methods] A total of 98 herpes zoster patients were divided randomly into treatment ( n = 50) and control ( n = 48) groups .Both groups received ganciclovir ,nerve cell nutrition and local wound care .Helium neon laser on each pain region for 10 min was used in treatment group but not in control group .And the therapeutic course was 7 days for both groups .[Results] In treatment group ,the out‐comes were healing ( n = 39) ,efficacious ( n = 9) ,effective ( n = 2) and ineffective ( n = 0) .And the overall effective rate was 96 .0% (48/50) .In control group ,healing ( n = 26) ,efficacious ( n = 9) ,effective ( n =11) and ineffective ( n = 2) .And the overall effective rate was 72 .9% (37/48) .The inter‐group difference was statistically significant (χ2 = 10 .066 ,P < 0 .01) .[Conclusion] Helium neon laser plus pharmacotherapy can control herpes zoster effectively so that it is worth wider popularization .

  15. Clinical observation of liquid nitrogen cryotherapy in the treatment of patients with herpes zoster and positive anti-HIV%液氮冷冻治疗带状疱疹合并抗-HIV阳性患者临床观察

    Institute of Scientific and Technical Information of China (English)

    徐蕾; 廖志敏

    2016-01-01

    目的:观察液氮冷冻治疗带状疱疹合并抗⁃HIV 阳性患者的临床疗效.方法:选取四川省凉山彝族自治州第二人民医院2012-03/2015-12收治的带状疱疹合并抗⁃HIV 阳性患者50例作为研究对象,将其随机分为冷冻组(n =24)和对照组(n=26),两组均予抗病毒、止痛、营养神经基础治疗,冷冻组同时给予液氮冷冻治疗,分别于治疗第7日、14日对两组患者进行疗效评估.结果:冷冻组与对照组第7日综合疗效比较,差异无统计学意义(P>0.05),冷冻组第14日综合疗效优于对照组,差异具有统计学意义(P<0.05).结论:液氮冷冻治疗带状疱疹合并抗⁃HIV 阳性患者疗效肯定,值得应用推广.%AIM: To observe the curative effect of liquid nitro⁃gen cryotherapy in the treatment of patients with herpes zoster and positive anti⁃HIV. METHODS: A total of 50 patients with herpes zoster and positive anti⁃HIV admitted into The Second Peoples Hospital of Liangshan Yi Autonomous Prefecture from March 2012 to December 2015 were selected as objects of study and randomly divided into freezing group( n = 24) and control group( n = 26), both of which received basic treatment such as antiviral, analge⁃sic, and neurotrophic treatments. The freezing group also received liquid nitrogen cryotherapy. The curative effect was evaluated on 7 and 14 days after the treatment respectively. RESULTS: For the comprehensive therapeutic effect on 7 days after the treatment, there was no statistically significant difference between the freez⁃ing group and control group (P>0.05). While the comprehensive therapeutic effect in freezing group on 14 days after the treatment was better than the control group, and the difference was statisti⁃cally significant ( P < 0. 05). CONCLUSION: Liquid nitrogen cryotherapy is an effective method for treating herpes zoster with positive anti⁃HIV patients, which is worthy of

  16. Study on clinical efficacy of resolving depression and detoxification powder (Chinese herbal medicine powder) in treatment of 146 cases of herpes zoster%从"郁"论治——应用自拟方解郁清毒散治疗带状疱疹146例临床分析

    Institute of Scientific and Technical Information of China (English)

    龙雄初; 龙枚飞; 李晓玲; 赵社海

    2012-01-01

    目的 探讨从"郁"论治带状疱疹及应用自拟方解郁清毒散治疗带状疱疹的疗效.方法 通过对带状疱疹多年来的诊治经验,结合目前带状疱疹的发病特点,应用Hamilton汉密尔顿抑郁量表(HAMD)(24项)为评定工具对带状疱疹患者进行心理调查与分析.并根据病因病机采用行气补虚、泻火解毒、通络止痛的方法,并结合现代医学药理研究成果组成的自拟方解郁清毒散治疗该病146例.结果 带状疱疹患者存在不同程度的抑郁,应用自拟方解郁清毒散治疗该病总有效率达95.89%.结论 解郁清毒散是治疗带状疱疹的有效药物,且临床应用简单、方便、价廉,能显著减少后遗神经痛的发生,亦无不良反应,值得临床推广使用.%Objective To explore the clinical effect of self - made prescription resolving depression and detoxification powder ( Jieyu Qingdu San ) originated from the theoretical concept of traditional Chinese medicine in treatment of patients with herpes zoster. Methods According to experience in treatment of herpes zoster, authors adopted the Hamilton Rating Scale for Depression ( 11AMD ) ( 24 items ) as rating system to study and analyze the psychological status of patients with herpes zoster. According to the pathogenesis, therapeutic method for moving qi ( gas ) and to nourish xu ( weakness ), purging fire to detoxify and freeing the collateral vessels to relieve pain were combined with modem pharmacological knowledge to formulate the self- made prescription for resolving depression and detoxifying powder in treatment of 146 patients with herpes zoster. Satisfactory effectiveness had been obtained. Results Most of patients with herpes zoster suffered from depression in varying degree. The clinical effect of self - made prescription resolving depression and detoxifying powder in treatment of patients with herpes zoster, is satisfactory, and its effective rate reached 95. 89% . Conclusion The application of

  17. Varicella-zoster virus-specific antibody responses in 50-59-year-old recipients of zoster vaccine.

    Science.gov (United States)

    Levin, Myron J; Schmader, Kenneth E; Gnann, John W; McNeil, Shelly A; Vesikari, Timo; Betts, Robert F; Keay, Susan; Stek, Jon E; Bundick, Nickoya D; Su, Shu-Chih; Zhao, Yanli; Li, Xiaoming; Chan, Ivan S F; Annunziato, Paula W; Parrino, Janie

    2013-11-01

    Prevaccination and 6-week postvaccination samples from the immunogenicity substudy (n = 2269) of the zoster vaccine (ZV) efficacy trial (N = 22 439) in 50-59-year-old subjects were examined for varicella-zoster virus-specific antibody responses to vaccination. The varicella-zoster virus geometric mean titer (GMT) and geometric mean fold rise were higher in ZV recipients than in placebo recipients (GMT, 660.0 vs 293.1 glycoprotein enzyme-linked immunosorbent assay units/mL [P < .001], respectively; geometric mean fold rise, 2.31 vs 1.00 [P < .025]). In each group there was a strong inverse correlation between postvaccination GMT and risk of subsequent herpes zoster. Although these data provide strong evidence that relates ZV-induced antibody and the risk of herpes zoster, a protective threshold was not determined. Clinical Trials Registration. NCT00534248.

  18. Varicella-Zoster Virus–Specific Antibody Responses in 50–59-Year-Old Recipients of Zoster Vaccine

    Science.gov (United States)

    Levin, Myron J.; Schmader, Kenneth E.; Gnann, John W.; McNeil, Shelly A.; Vesikari, Timo; Betts, Robert F.; Keay, Susan; Stek, Jon E.; Bundick, Nickoya D.; Su, Shu-Chih; Zhao, Yanli; Li, Xiaoming; Chan, Ivan S. F.; Annunziato, Paula W.; Parrino, Janie

    2013-01-01

    Prevaccination and 6-week postvaccination samples from the immunogenicity substudy (n = 2269) of the zoster vaccine (ZV) efficacy trial (N = 22 439) in 50–59-year-old subjects were examined for varicella-zoster virus–specific antibody responses to vaccination. The varicella-zoster virus geometric mean titer (GMT) and geometric mean fold rise were higher in ZV recipients than in placebo recipients (GMT, 660.0 vs 293.1 glycoprotein enzyme-linked immunosorbent assay units/mL [P < .001], respectively; geometric mean fold rise, 2.31 vs 1.00 [P < .025]). In each group there was a strong inverse correlation between postvaccination GMT and risk of subsequent herpes zoster. Although these data provide strong evidence that relates ZV-induced antibody and the risk of herpes zoster, a protective threshold was not determined. Clinical Trials Registration. NCT00534248. PMID:23908486

  19. Clinical Analysis of Combination of Traditional Chinese and Western Medicine Treatment Of herpes Zoster%带状疱疹中西医结合治疗的临床分析

    Institute of Scientific and Technical Information of China (English)

    宋福松

    2015-01-01

    目的:分析带状疱疹中西医结合治疗的临床疗效。方法将患者随机分为观察组与对照组,对照组使用抗病毒药物、止痛药物等西医治疗方法,观察组在西医治疗基础上使用拔火罐并且配合穴位注射等中医治疗方法,对比两组患者的临床治疗效果。结果对比两组患者的总有效率差异,观察组治疗效果明显优于对照组,存在统计学意义(P<0.05)。结论使用中西医结合治疗带状疱疹,治疗效果要优于单一使用西医治疗方法,而且不良发应发生几率低,是一项可行的治疗方法,值得进行临床推广。%Objective To analyze the clinical effect of combined traditional Chinese and Western medicine treatment of herpes zoster.Methods Patients were randomly divided into observation group and control group, the control group use of antiviral drugs,painkilers and other Western medicine treatment, the observation group in western medicine treatment on the basis of the use of cupping and acupoint injection in TCMtreatment, compared two groups of patients with clinical curative effect.ResultsThe totalefficiency differences were compared between two groups, the observation grouptreatment effect is significantly better than the control group, there was statistical significant difference (P< 0.05).Conclusion The use of traditional Chinese and Western medicine treatment of herpes zoster, treatment effect than single use of Western medicine totreatment, and adverse should occur probability is low, it is a feasible treatment method, is worthy of clinical promotion.

  20. Clinical effect of nerve block combined with ozone treatment on Herpes Zoster%神经阻滞联合臭氧治疗带状疱疹的疗效观察

    Institute of Scientific and Technical Information of China (English)

    张玉红; 张永红; 肖春才; 彭希亮; 郑战伟; 倪文琼

    2016-01-01

    目的:观察神经阻滞联合臭氧防治带状疱疹后遗神经痛的临床疗效。方法将75例带状疱疹患者随机分为3组,A组口服加巴喷丁胶囊,300 mg/次,3次/d;B组采用神经阻滞治疗;C组采用神经阻滞联合臭氧治疗。于治疗前、治疗1周及治疗后3个月进行VAS评分检测,综合评价治疗效果。结果3组患者治疗后评分均低于治疗前(<0.05),C组疼痛缓解、痊愈时间短于A、B组(<0.05),无PHN发生。结论神经阻滞联合臭氧治疗带状疱疹是安全、有效、便捷的方法。%Objective To observe the clinical curative effect of nerve block combined with ozone treatment of postherpetic neuralgia (PHN). Methods Seventy-five patients with Herpes Zoster were randomly divided into three groups. Group A took 300 mg of Gabapentin capsules orally 3 times a day, group B was treated with nerve block, and group C was treated with nerve block combined with ozone therapy. Before treatment, 1 week and 3 months after treatment VAS score was evaluated, the treatment effect was comprehensively evaluated. Results In the three groups, VAS scores after treatment were lower than those before treatment ( < 0.05). Pain relief and recovery time of the group C was shorter than that of the groups A and B ( <0.05). No PHN occurred. Conclusions Nerve block combined with ozone is a safe, effective and convenient therapy for Herpes Zoster.

  1. 中药佐治老年HIV/AIDS合并带状疱疹疗效观察%Effect of traditional Chinese medicine combined with acyclovir on herpes zoster in elderly with HIV/AIDS

    Institute of Scientific and Technical Information of China (English)

    梁飞立; 苏文桂; 何艳英; 余丰; 方鹏

    2012-01-01

    Objective It is to observe the effect of traditional Chinese medicine combined with acyclovir on herpes zoster in 30 elderly patients with HIV/AIDS. Methods Sixty elderly patients with HIV/AIDS were randomly divided into two groups. Thirty patients in treatment group were treated with external application of traditional Chinese medicine combined with acyclovir; thirty patients in control group were treated with acyclovir only. Results In treatment group, 17 cases were cured and 9 cases were improved, the effective rate was 87% . In control group, 14 cases were cured and 4 cases were improved, the effective rate was 60% . There was significantly difference in effective rate between both groups. The cured time of skin lesions was ( 16.17 ± 5. 47 ) days in treatment group, and was ( 20. 50 ± 6. 35 ) days in control group, there was significant difference between both groups. Conclusion External application of traditional Chinese medicine combined with acyclovir can shorten healing time of skin lesions caused by herpes zoster in the elderly with IV/AIDS and increase cure rate.%目的 探讨中药外敷配合阿昔洛韦治疗老年HIV/AIDS合并带状疱疹的疗效.方法 60例患者随机分为2组,治疗组30例用中药外敷及阿昔洛韦静脉滴注,对照组30例单用阿昔洛韦静脉滴注.结果 治疗组治愈17 例,好转9例,未愈4例,治愈好转率87%(26/30);对照组治愈14 例,好转4例,未愈12例,治愈好转率60%(18/30);2组治愈好转率比较有显著性差异(2 =5.455,P<0.05).治疗组疱疹愈合时间(16.17±5.47)d,对照组(20.50±6.35)d,2组疱疹愈合时间比较有显著性差异(t=-2.833,P<0.05).结论 中药外敷配合阿昔洛韦治疗老年HIV/AIDS 合并带状疱疹患者能缩短疱疹愈合时间,提高治愈好转率.

  2. Seroprevalence of hepatitis A virus and varicella zoster antibodies in a Javanese community (Yogyakarta, Indonesia).

    Science.gov (United States)

    Juffrie, M; Graham, R R; Tan, R I; Widjaja, S; Mulyadi, S; Weil, J; Bock, H L

    2000-03-01

    Hepatitis A virus (HAV) cause an acute inflammation of the liver. Varicella-zoster virus (VZV) cause chickenpox (varicella) and herpes zoster. Effective vaccines against hepatitis A and varicella are available for children, adolescents and adults. In order to implement an appropriate vaccination policy, a baseline to assess the potential benefits and sections of the population who would benefit most are required. We investigated seroprevalence of hepatitis A virus and varicella zoster antibodies in a Javanese community. A total of 1,103 subjects were studied. The 600 subjects aged 4 to 9 years were sampled between 23 October and 2 November, 1995. The other subjects were sampled between 12 October and 1 November, 1996. The overall prevalence of anti-HAV in cohort was 28.7%. Anti-HAV seroprevalence rates were below 30% until the age of 15 and below 40% until the age of 25. The anti-varicella seroprevalence showed only in two thirds of seropositive population at the age of 15. The results of the study have implications for vaccination strategies for both hepatitis A and varicella zoster.

  3. [VARICELLA ZOSTER VIRUS AND DISEASES OF CENTRAL NERVOUS SYSTEM VESSELS].

    Science.gov (United States)

    Kazanova, A S; Lavrov, V F; Zverev, V V

    2015-01-01

    Systemized data on epidemiology, pathogenesis, clinical manifestation, diagnostics and therapy of VZV-vasculopathy--a disease, occurring due to damage of arteries of the central nervous system by Varicella Zoster virus, are presented in the review. A special attention in the paper is given to the effect of vaccine prophylaxis of chicken pox and herpes zoster on the frequency of development and course of VZV-vasculopathy.

  4. Clinical observation of helium-neon laser for herpes zoster in elderly patients%氦氖激光治疗老年带状疱疹的临床观察

    Institute of Scientific and Technical Information of China (English)

    石长珠; 朱应玉

    2016-01-01

    Objective:To observe the clinical efficacies of treatment of herpes zoster in elderly patients with helium-neon laser.Methods:A total of 67 pa-tients,aged over 60 years and treated on the outpatient basis in our hospital ,were recruited from August 2014 to February 2016,and randomly allocated to observational group(laser treatment,n=33) and control group(n=34).Patients in the control group received exclusive antivirus with valacyclovir hydro-chloride tablets and mecobalamin tablets as well as neurotorophic maintenance with vitamin B 1,and those in the observational group were given additional helium-neon laser treatment on the medication basis.All patients were followed up for 4 weeks.The time of crust formation and decrustation as well as daily scores on pain was maintained in the two groups,and the sequel neuralgia was observed 4 weeks after treatment.Results:The observational group had signif-icantly shorter time of crust formation and decrustation as well as lower pain scores following the 3rd day after treatment and fewer incidence of neuralgia than the control group(P<0.05).Conclusion:Helium-neon laser may lead to better clinical efficacies for herpes zoster in elderly patients ,with shorter time of crust formation and decrustation,early pain relief and less neurological sequelae.%目的:探讨氦氖激光在老年带状疱疹患者中的治疗效果。方法:选取2014年8月~2016年2月在我院皮肤性病科门诊确诊为带状疱疹且年龄≥60岁的老年患者共67例,随机分为氦氖激光组(观察组)和对照组,对照组34例仅接受盐酸伐昔洛韦分散片抗病毒、甲钴胺片及维生素B1营养神经等治疗,观察组33例在接受对照组药物治疗基础上给予氦氖激光治疗;随访4周,记录两组患者的结痂时间、脱痂时间,每日疼痛评分及4周后的后遗神经痛发生情况。结果:观察组的结痂时间、脱痂时间、治疗第3天以后每日疼痛评分以及后遗神经

  5. 中西医结合治疗带状疱疹临床研究%Clinical Study on the Treatment of Herpes Zoster by Integration of Traditional Chinese Medicine and Western Medicine

    Institute of Scientific and Technical Information of China (English)

    张娟

    2012-01-01

    Objective:To study the clinical effects of the integration of TCM and western medicine on the treatment of Herpes Zoster. Methods: 64 patients were randomly divided into the control group and the treatment group. The control group of 32 cases was given 2 mL of intramuscular injection of antiviral poly I : C,with once per two days and oral adminstration of 25 mg indomethacin,three time a day; the treatment group of 32 cases was additionally given Chinese herbs on the basis of treatment given to the control group with the composition of Gentiana scabra Bunge 10 g, Honeysuckle flower 30 g, Radix bupleuri 10 g,Paeonia suffruticosa 10 g, Radix Paeoniae Rubra 10 g,Rehmannia root 15 g,Mongolian Dandelion 10 g,Rhizoma alismatis 10 g,Akebiaquinata 10 g,Angelica sinensis 10 g.Fruc-tus Gardeniae 10 g,Forsythia 10 g, Folium isatidis 30 g, Radix lsatidis 30 g. Anther lignum dalbergiae odoriferae 10 g and Angelica sinensis 30 g were added if there was blood stasis,one dosage a day with a treatment course of 7 days. Results:In the treatment group, 24 cases were cured,6 cases achieved excellent effects,2 were ineffective and the effective rate was 93. 7% ;in the control group,18 cases were cured, 8 achieved excellent effects, 6 were ineffective, and the effective rate was 81.3%. Effective rates of two groups had notable significance through statistics processing(P <0. 05). Conclusion: Herpes Zoster can be treated effectively by the treatment of integration of TCM and western medicine.%目的:探讨中西医结合治疗带状疱疹临床疗效.方法:64例患者随机分为对照组和治疗组.对照组32例肌肉注射抗病毒类聚肌胞针2 mL,2d1次;口服消炎痛25 mg,每日3次,治疗组32例在对照组基础上加用中药治疗.中药选用龙胆草10g,金银花30 g,柴胡10 g,牡丹皮10 g,赤芍10 g,生地黄15 g,蒲公英10 g,泽泻10 g,木通10 g,当归10 g,栀子10 g,连翘10 g,大青叶30 g,板兰根30 g.伴有瘀血者加降香10 g,当归10 g,日1

  6. Characteristics on the Diagnosis and Treatment of Diabetic Facial Paralysis Patients with Herpes Zoster%糖尿病合并带状疱疹性面神经炎诊治特点探讨

    Institute of Scientific and Technical Information of China (English)

    谌剑飞; 邱明琪

    2015-01-01

    Objective To investigate the clinical characteristics on the diagnosis and treatment of diabetic facial paralysis patients with herpes zoster.Methods The clinical data in diabetic facial paralysis patients with herpes zoster were retrospectively analyzed. The clinical characteristics of diabetic patients with or without herpetic facial paralysis were compared.Results The nerve function grade and scores in diabetic patients with herpetic facial paralysis were higher than that in diabetic patients without herpetic facial paralysis (P<0.01). After treatment,the scores of nerve function were decreased in two groups (P<0.01).The cure rate and markedly effec-tive rate were 52.4% and 77.9% in diabetic patients without herpetic facial paralysis,which were higher than that in diabetic patients with herpetic facial paralysis(28.6% and 51.2%,P<0.01). Conclusion The lesions in diabetic patients with herpetic facial paralysis were more serious,which functional recovery was less than that in diabetic patients without herpetic facial paralysis.Early treatment by integrated Chinese and western medicine can improve the curative effect.%目的:探讨糖尿病带状疱疹性面神经炎临床特点,以提高对本病的诊治认识水平和疗效。方法回顾分析糖尿病带状疱疹性面神经炎患者临床诊治资料,并与无疱疹糖尿病面神经炎者进行比较。结果糖尿病带状疱疹性面神经炎者神经功能分级和评分量值,均较无疱疹性糖尿病面神经炎者为高,具有统计学意义(P<0.01);中西医结合治疗前后两组面神经功能评分量值自身比较有统计学意义(P<0.01);治愈率及愈显率分别为28.6%、51.2%与52.4%、77.9%,具有统计学意义(P<0.01)。结论糖尿病带状疱疹性面神经炎者病变较重,恢复功能较无疱疹性面神经炎者差,早期采用中西医结合治疗有助于提高疗效。

  7. Kyrieleis plaques associated with Herpes Simplex Virus type 1 acute retinal necrosis

    Directory of Open Access Journals (Sweden)

    Neha Goel

    2016-04-01

    Full Text Available We report the case of a 55-year-old immunocompetent male who presented with features typical of acute retinal necrosis (ARN. Polymerase chain reaction of the aqueous tap was positive for Herpes Simplex Virus (HSV – 1. Following therapy with intravenous Acyclovir, followed by oral Acyclovir and steroids, there was marked improvement in the visual acuity and clinical picture. At one week after initiation of treatment, Kyrieleis plaques were observed in the retinal arteries. They became more prominent despite resolution of the vitritis, retinal necrosis and vasculitis and persisted till six weeks of follow-up, when fluorescein angiography was performed. The appearance of this segmental retinal periarteritis also known as Kyrieleis plaques has not been described in ARN due to HSV-1 earlier.

  8. Low Prevalence of Varicella Zoster Virus and Herpes Simplex Virus Type 2 in Saliva from Human Immunodeficiency Virus-Infected Persons in the Era of Highly Active Antiretroviral Therapy

    Science.gov (United States)

    Wang, Chunmei C.; Yepes, Luis C.; Danaher, Robert J.; Berger, Joseph R.; Mootoor, Yunanan; Kryscio, Richard J.; Miller, Craig S.

    2009-01-01

    Objectives Human herpesviruses (HHVs), e.g. herpes simplex virus (HSV) type 1, Epstein-Barr virus and cytomegalovirus, appear in saliva at greater frequency in persons infected with human immunodeficiency virus (HIV) than healthy individuals. However, it is not known if varicella zoster virus (VZV) and HSV-2 appear simultaneously during HIV infection at greater frequency in saliva during this era of highly active antiretroviral therapy (HAART). The aim of this study was to investigate the prevalence and amounts of VZV and HSV-2 in the saliva of HIV-infected, orally asymptomatic patients. Study Design Quantitative polymerase chain reaction was used to investigate the prevalence, quantity, risk, and correlates of salivary VZV and HSV-2 from 59 HIV-seropositive individuals and 53 healthy controls in a case-control, cross-sectional study. Seventy-eight percent of the HIV-seropositive patients (46/59) were taking HAART. Results VZV DNA was detected in the saliva of 5.1% (3/59) of the HIV-positive group and in only one healthy control 1.9% (1/53; P = 0.62). The amount of VZV DNA in the expressors was low, generally less than 1,100 copies/mL with no observed difference between the HIV-positive group and the controls (P= 1.0). HSV-2 DNA was not detected in either group. In the HIV-infected group, VZV shedding occurred in those on HAART, but was not associated with oral lesions, specific CD4+ or CD8+ T-cell levels, or demographic factors. Conclusions VZV was detected at low prevalence in the saliva of HIV-infected persons whereas HSV-2 was not detected in the saliva of this cohort. HAART does not appear to diminish the risk for asymptomatic VZV shedding. PMID:20123407

  9. Effect of acute Plasmodium falciparum malaria on reactivation and shedding of the eight human herpes viruses.

    Directory of Open Access Journals (Sweden)

    Arnaud Chêne

    Full Text Available Human herpes viruses (HHVs are widely distributed pathogens. In immuno-competent individuals their clinical outcomes are generally benign but in immuno-compromised hosts, primary infection or extensive viral reactivation can lead to critical diseases. Plasmodium falciparum malaria profoundly affects the host immune system. In this retrospective study, we evaluated the direct effect of acute P. falciparum infection on reactivation and shedding of all known human herpes viruses (HSV-1, HSV-2, VZV, EBV, CMV, HHV-6, HHV-7, HHV-8. We monitored their presence by real time PCR in plasma and saliva of Ugandan children with malaria at the day of admission to the hospital (day-0 and 14 days later (after treatment, or in children with mild infections unrelated to malaria. For each child screened in this study, at least one type of HHV was detected in the saliva. HHV-7 and HHV-6 were detected in more than 70% of the samples and CMV in approximately half. HSV-1, HSV-2, VZV and HHV-8 were detected at lower frequency. During salivary shedding the highest mean viral load was observed for HSV-1 followed by EBV, HHV-7, HHV-6, CMV and HHV-8. After anti-malarial treatment the salivary HSV-1 levels were profoundly diminished or totally cleared. Similarly, four children with malaria had high levels of circulating EBV at day-0, levels that were cleared after anti-malarial treatment confirming the association between P. falciparum infection and EBV reactivation. This study shows that acute P. falciparum infection can contribute to EBV reactivation in the blood and HSV-1 reactivation in the oral cavity. Taken together our results call for further studies investigating the potential clinical implications of HHVs reactivation in children suffering from malaria.

  10. Epidemiological characteristics and societal burden of varicella zoster virus in the Netherlands

    NARCIS (Netherlands)

    Pierik, Jorien G. J.; Gumbs, Pearl D.; Fortanier, Sander A. C.; Van Steenwijk, Pauline C. E.; Postma, Maarten J.

    2012-01-01

    Background: Varicella and herpes zoster are both caused by varicella zoster virus (VZV) infection or reactivation and may lead to complications associated with a (severe) societal burden. Because the epidemiology of VZV-related diseases in the Netherlands remains largely unknown or incomplete, the m

  11. Necrosis of nose skin after varicella zoster infection : A case report

    NARCIS (Netherlands)

    Snel, Bart Jorrit; Visconti, Giuseppe; Grabietz, Patrice D.; Werker, Paul M. N.

    2010-01-01

    Varicella zoster virus (VZV) is the causal agent of varicella (chickenpox) and herpes zoster (shingles). Primary VZV infection is a common childhood disease, but elderly patients and those having a compromised immune system are also at risk. We present the case of progressive necrosis of the nose sk

  12. Varicella zoster virus vaccines: potential complications and possible improvements

    Institute of Scientific and Technical Information of China (English)

    Benjamin; Silver; Hua; Zhu

    2014-01-01

    Varicella zoster virus(VZV) is the causative agent of varicella(chicken pox) and herpes zoster(shingles). After primary infection, the virus remains latent in sensory ganglia, and reactivates upon weakening of the cellular immune system due to various conditions, erupting from sensory neurons and infecting the corresponding skin tissue. The current varicella vaccine(v-Oka) is highly attenuated in the skin, yet retains its neurovirulence and may reactivate and damage sensory neurons. The reactivation is sometimes associated with postherpetic neuralgia(PHN), a severe pain along the affected sensory nerves that can linger for years, even after the herpetic rash resolves. In addition to the older population that develops a secondary infection resulting in herpes zoster, childhood breakthrough herpes zoster affects a small population of vaccinated children. There is a great need for a neuro-attenuated vaccine that would prevent not only the varicella manifestation, but, more importantly, any establishment of latency, and therefore herpes zoster. The development of a genetically-defined live-attenuated VZV vaccine that prevents neuronal and latent infection, in addition to primary varicella, is imperative for eventual eradication of VZV, and, if fully understood, has vast implications for many related herpesviruses and other viruses with similar pathogenic mechanisms.

  13. Microgravity Analogues of Herpes Virus Pathogenicity: Human Cytomegalovirus (hCMV) and Varicella Zoster (VZV) Infectivity in Human Tissue Like Assemblies (TLAs)

    Science.gov (United States)

    Goodwin, T. J.; McCarthy, M.; Albrecht, T.; Cohrs, R.

    2009-01-01

    The old adage we are our own worst enemies may perhaps be the most profound statement ever made when applied to man s desire for extraterrestrial exploration and habitation of Space. Consider the immune system protects the integrity of the entire human physiology and is comprised of two basic elements the adaptive or circulating and the innate immune system. Failure of the components of the adaptive system leads to venerability of the innate system from opportunistic microbes; viral, bacteria, and fungal, which surround us, are transported on our skin, and commonly inhabit the human physiology as normal and imunosuppressed parasites. The fine balance which is maintained for the preponderance of our normal lives, save immune disorders and disease, is deregulated in microgravity. Thus analogue systems to study these potential Risks are essential for our progress in conquering Space exploration and habitation. In this study we employed two known physiological target tissues in which the reactivation of hCMV and VZV occurs, human neural and lung systems created for the study and interaction of these herpes viruses independently and simultaneously on the innate immune system. Normal human neural and lung tissue analogues called tissue like assemblies (TLAs) were infected with low MOIs of approximately 2 x 10(exp -5) pfu hCMV or VZV and established active but prolonged low grade infections which spanned .7-1.5 months in length. These infections were characterized by the ability to continuously produce each of the viruses without expiration of the host cultures. Verification and quantification of viral replication was confirmed via RT_PCR, IHC, and confocal spectral analyses of the respective essential viral genomes. All host TLAs maintained the ability to actively proliferate throughout the entire duration of the experiments as is analogous to normal in vivo physiological conditions. These data represent a significant advance in the ability to study the triggering

  14. Comparison of intramuscular and subcutaneous administration of a herpes zoster live-attenuated vaccine in adults aged ≥50 years: a randomised non-inferiority clinical trial.

    Science.gov (United States)

    Diez-Domingo, Javier; Weinke, Thomas; Garcia de Lomas, Juan; Meyer, Claudius U; Bertrand, Isabelle; Eymin, Cécile; Thomas, Stéphane; Sadorge, Christine

    2015-02-04

    Zostavax(®) is a live, attenuated varicella zoster virus (VZV) vaccine developed specifically for the prevention of HZ and PHN in individuals aged ≥50 years. During the clinical development of Zostavax, which was mainly in the US, the vaccine was administrated by the subcutaneous (SC) route. In Europe, many healthcare professionals prefer administering vaccines by the intramuscular (IM) route. This was an open-label, randomised trial conducted in 354 subjects aged ≥50 years. The primary objectives were to demonstrate that IM administration is both non-inferior to SC administration in terms of 4-week post-vaccination geometric mean titres (GMTs), and elicits an acceptable geometric mean fold-rise (GMFR) of antibody titres measured by glycoprotein enzyme-linked immunosorbent assay. Pre-specified non-inferiority was set as the lower bound of the 95% confidence interval (CI) of the GMT ratio (IM/SC) being >0.67. An acceptable GMFR for the IM route was pre-specified as the lower bound of its 95% CI being >1.4. Description of the VZV immune response using the interferon-gamma enzyme-linked immunospot (IFN-γ ELISPOT) assay and of the safety were secondary objectives. Participants were randomised to IM or SC administration (1:1). The baseline demographics were comparable between groups; mean age: 62.6 years (range: 50.0-90.5). The primary immunogenicity objectives were met (per protocol analysis): GMT ratio (IM/SC): 1.05 (95% CI: 0.93-1.18); GMFR: 2.7 (2.4-3.0). VZV immune response using IFN-γ ELISPOT were comparable between groups. Frequencies of systemic adverse events were comparable between groups. Injection-site reactions were less frequent with IM than SC route: erythema (15.9% versus 52.5%), pain (25.6% versus 39.5%) and swelling (13.6% versus 37.3%), respectively. In adults aged ≥50 years, IM administration of Zostavax elicited similar immune responses to SC administration and was well tolerated, with fewer injection-site reactions than with SC

  15. STUDY REPORTS ON VARICELLA ZOSTER IN TERM PREGNANCY AND ITS OUTCOME

    Directory of Open Access Journals (Sweden)

    Pranjal

    2014-06-01

    Full Text Available Chickenpox is caused by the Varicella-Zoster virus, a member of the herpes virus family. The same virus also causes herpes zoster (shingles in adults. This infection can be widely detected in developing countries, especially for those tropical countries. It is presented with fever and vesicular lesions all over body. (1,2 Even the pregnant women can get chicken pox, and this becomes an important concern. In this specific paper, we have given the details and discussed 5 cases on chicken pox in term pregnancy and its outcome. We have also discussed the management of VZV (Varicella Zoster Virus infection in pregnancy.

  16. The Role of Plasmacytoid Dendritic Cells in Innate and Adaptive Immune Responses against Alpha Herpes Virus Infections

    Directory of Open Access Journals (Sweden)

    Philipp Schuster

    2011-01-01

    Full Text Available In 1999, two independent groups identified plasmacytoid dendritic cells (PDC as major type I interferon- (IFN- producing cells in the blood. Since then, evidence is accumulating that PDC are a multifunctional cell population effectively coordinating innate and adaptive immune responses. This paper focuses on the role of different immune cells and their interactions in the surveillance of alpha herpes virus infections, summarizes current knowledge on PDC surface receptors and their role in direct cell-cell contacts, and develops a risk factor model for the clinical implications of herpes simplex and varicella zoster virus reactivation. Data from studies involving knockout mice and cell-depletion experiments as well as human studies converge into a “spider web”, in which the direct and indirect crosstalk between many cell populations tightly controls acute, latent, and recurrent alpha herpes virus infections. Notably, cells involved in innate immune regulations appear to shape adaptive immune responses more extensively than previously thought.

  17. Varicella-zoster virus reactivation from multiple ganglia: a case report

    Directory of Open Access Journals (Sweden)

    Hashemilar Mazyar

    2009-09-01

    Full Text Available Abstract Introduction Simultaneous involvements of multiple cranial nerve ganglia (geniculate ganglion and peripheral ganglia of cranial nerves VIII, IX and X by varicella-zoster virus and its subsequent activation may result in the characteristic eruptions of herpes zoster cephalicus. Coexistence of facial palsy and involvement of upper cervical dermatomes by varicella-zoster virus is quite rare. Case presentation Here, we report a 71-year-old Iranian man with involvement of multiple sensory ganglia (geniculate ganglion and upper dorsal root ganglia by varicella-zoster virus. He presented with right-sided facial weakness along with vesicular eruptions on the right side of his neck, and second and third cervical dermatomes. Conclusion The present case is an example of herpes zoster cephalicus with cervical nerve involvement. Although resembling Ramsay Hunt syndrome with presence of facial nerve paralysis and accompanying vesicles, involvement of cervical dermatomes is not a feature of the classic Ramsay Hunt syndrome.

  18. 针刺结合火罐治疗带状疱疹的临床疗效分析%Clinical analysis of the efficacy of acupuncture combined with cupping treatment of herpes zoster

    Institute of Scientific and Technical Information of China (English)

    何二代

    2015-01-01

    目的:分析带状疱疹通过针刺联合火罐治疗的临床效果。方法:研究对象来自我院在2011年1月至2014年I2月期间接诊的50例带状疱疹患者,分为对照组和观察组各25例,其中观察组采用针刺联合火罐治疗,对照组采用西药抗病毒治疗,而后对比两组患者的治疗效果差异。结果:在治疗有效率上,观察组为100%,对照组为84%;同时在治疗有效性显现时间上,观察组均快于对照组。两组比较具有统计学意义,P<0.05。结论:带状疱疹通过针刺联合火罐治疗可以有效的提升治疗有效率,同时起效快速,降低患者的不适感,提升患者生活质量。%Objective To analyze the clinical effects of herpes zoster by acupuncture combined with cupping therapy.Methods 50 patients were divided into two groups, the observation group were treated with acupuncture combined with cupping therapy, the control group with western medicine antiviral therapy, then contrast differences.ResultsThe effective rate in observation group was 100% vs 84%;at the same time show the effectiveness of the treatment, the observation group were faster than the control group.ConclusionShingles treatment by acupuncture combined with cupping therapy can effectively improve efficiency.

  19. The Observation about the Effect on Post-herpetic Neuralgia of Herpes Zoster by Early Intervention with Venesection Ventouse and Helium-neon Laser%刺络拔罐联合氦氖激光早期干预对带状疱疹后遗神经痛影响观察

    Institute of Scientific and Technical Information of China (English)

    夏立君; 蒋靖

    2012-01-01

    目的:刺络拔罐联合氦氖激光早期干预对带状疱疹后遗神经痛的影响观察.方法:将具有典型症状的带状疱疹患者140例随机分为两组,对照组口服伐昔洛韦胶囊、维生素B1、甲钴胺.治疗组除服用上述药外于病变处照氦氖激光并联合刺络拔罐.两组患者分别于治疗后进行临床疗效评估及治疗结束后进行3个月随访观察后遗神经痛现象.结果:治疗结束时,对照组有效率为95.7%,治疗组有效率为97.1%.两组疗效差异无显著性(P>0.05),而两者后遗神经痛率分别为21.4%、8.2%,差异有显著性(P<0.05).结论:刺络拔罐联合氦氖激光早期干预可明显减轻对带状疱疹后遗神经痛.%Objective : Observe the effect on post-herpetic neuralgia of herpes zoster by early intervention with venesection ventouse and helium-neon laser. Method: Divided the selected 140 patients of classical symptom of herpes zoster into two groups randomly: the control group used Valaciclovir, VitaminsB,, mecobalamin. While the treatment group expcet taked above-medicine, treated with venesection ventouse and helium-neon laser at the pathological change. Taked clinical curative effect evaluation after different treatment and observed the phenomenon of post-herpetic neuralgia after follow up-3weeks. Results: After the treatment, the effective rates of the control group and the treatment group were respectively 95.7%and 97.1%. There were no significant difference between two groups ( P>0.05 ) .The post-herpetic neuralgia rates of the two groups were 21.4%, 8.2%respectively, there were significant differences ( P<0.05 ). Conclusion: Venesection ventouse combined with helium-neon laser can relieve post-herpetic neuralgia of herpes zoster obviously.

  20. The clinical research of the efifcacy of Troxerotin and cerebro hydrolysate injection(TCHI) for the treatment of Neuralgia of herpes zoster%复方曲肽注射液治疗带状疱疹性神经痛的效果研究

    Institute of Scientific and Technical Information of China (English)

    田刘军; 范天仁; 尹凤婷; 周楠; 张伟丽

    2016-01-01

    目的:研究复方曲肽注射液对带状疱疹性神经痛患者的作用效果。方法选取2014年9月~2015年6月在我科住院的诊断明确的带状疱疹性神经痛患者60例,将其随机分为治疗组与对照组,各30例,对照组采用阿昔洛韦、维生素B1、维生素B12等常规治疗,治疗组加用复方曲肽注射液,疗程为2周。结果治疗组有效率83.3%,对照组有效率50%,两组比较差异有统计学意义(P<0.05)。结论复方曲肽注射液在治疗带状疱疹性神经痛方面起到显著疗效。%objective To investigate the efifcacy of troxerotin and cerebro hydrolysate injection(TCHI) in the treatment of neuralgia of herpes zoster.Methods Select September201-June2015in our hospital diagnosis of herpes zoster neuralgia clear60patients were randomly divided into treatment group and control group(30cases),30cases in treatment group were administrated with troxerotin and cerebro hydrolysate injection(TCHI),while the other 30 cases in the control group were given conventional treatment,one course lasted2week.Results The effective rates were83.3%and50%(P<0.05)in the therapeutic group and the control group,respectively.Conclusion Troxerotin and cerebro hydrolysate injection(TCHI)plays a significant effect in terms of the treatment of neuralgia of herpes zoster.

  1. Clinical investigation of prednisone combined with mecobalamin and indomethecin in the treatment of neuralgia following herpes zoster%强的松联合甲钴胺及吲哚美辛治疗带状疱疹后遗神经痛的疗效观察

    Institute of Scientific and Technical Information of China (English)

    潘忠泉

    2013-01-01

    Objective To observe the clinical effect of prednisone combined with mecobalamin and indomethecin in the treatment of neuralgia following herpes zoster. Methods Eighty-six patients with neuralgia following herpes zoster were randomly divided into the treatment group (n=43) and the control group (n=43). Patients in the treatment group were treated with prednisone 10 mg three times daily, mecobalamin 500 μg three times daily, and in-domethacin 25 mg two times daily for 15 days. Patients in the control group were treated with mecobalamin 500 μg three times daily and indomethacin 25 mg two times daily for 15 days. The visual analogue scale (VAS) was used to evaluate the therapeutic effects in the two groups. Results The effective rate was 83.72% in the treatment group, significantly higher than that in the control group (65.12%), P<0.05. No marked side effects were observed in the two groups. Conclusion Prednisone combined with mecobalamin and indomethecin are effective and safe for treating neuralgia following herpes zoster.%目的 评价强的松片联合甲钴胺片及吲哚美辛片治疗带状疱疹后遗神经痛的临床疗效.方法 86例带状疱疹后遗神经痛患者分为治疗组及对照组各43例,治疗组患者口服强的松片10 mg,3次/d;甲钴胺片500 μg,3 次/d,吲哚美辛片25 mg,2 次/d,疗程15 d;对照组患者口服甲钴胺片500 μg,3 次/d,吲哚美辛片25 mg,2 次/d,疗程15 d.以视觉模拟评分法(VAS)评价治疗效果.结果 治疗组患者有效率(83.72%)高于对照组(65.12%),差异有统计学意义(P<0.05),两组患者均无明显不良反应.结论 强的松联合甲钴胺及吲哚美辛治疗带状疱疹后遗神经痛有明显疗效.

  2. Herpes viruses, cytokines, and altered hemostasis in vital exhaustion.

    NARCIS (Netherlands)

    Ven, A.J.A.M. van der; Diest, R. van; Hamulyak, K.; Maes, M.; Bruggeman, C.A.; Appels, A.

    2003-01-01

    OBJECTIVE: Infections with herpes viruses have been implicated in the pathogenesis of atherosclerosis. We tested the hypothesis that vital exhaustion (VE) is associated with multiple herpesvirus infections, such as herpes simplex virus, varicella-zoster virus, Epstein-Barr virus, and cytomegalovirus

  3. 带状疱疹疫苗生产中2BS细胞细胞工厂培养工艺的建立%Development of culture procedure for 2BS cell factory during production of herpes zoster vaccine

    Institute of Scientific and Technical Information of China (English)

    梁雪; 刘延威; 张宇; 石磊; 杨晓叶; 李生军; 沈红杰

    2014-01-01

    Objective To develop a culture procedure for 2BS cell factory during production of herpes zoster vaccine.Methods The 2BS cells were resuscitated (passage 28) and subcultured to passages 35 and 36,then to the ten layer cell factory at mass ratios of 1 ∶ 4 and 1 ∶ 2 respectively.The cells on each layer were added with various volumes (200,300 and 400 ml) of medium,observed for morphology by microscopy and counted.The cell factory was inoculated with varicellazoster virus at a MOI of 0.008 and prepared into live attenuated vaccine.The bulk and final product of vaccine were determined for titers.The final product was subjected to stability test at 37 ℃.The residual antibiotics and bovine albumin contents were determined by ELISA,while the endotoxin content by gel method,and the moisture content by volume titration method.Results Dense 2BS cell monolayer with high quality was prepared by subculture at a mass ratio of 1 ∶ 2 and addition of 300 ml of medium,of which the CPE reached more than 80% at time of harvest.The cells with CPE were round,most of which were in typical shape.The titers of bulk and final product of vaccine prepared with cells subcultured at a mass ratio of 1 ∶ 4 were significantly lower than those at 1 ∶ 2.However,the titer in stability test at 37 ℃ of final product of vaccine prepared with the cells subcultured at a mass ratio of 1 ∶ 4 failed to met the requirements of not less than 4.6 lgPFU/ml after storage for one week.Other indexes met the relevant requirements.Conclusion A culture procedure for 2BS cell factory during production of herpes zoster vaccine was developed,by which dense 2BS cells with even and high quality were prepared.%目的 建立带状疱疹疫苗生产中2BS细胞在细胞工厂中的培养工艺.方法 将2BS细胞复苏(28代)后,连续传代至35、36代,再分别按1∶4、1∶2比例传至10层细胞工厂中,采用不同的加液量(200、300、400 ml/层)进行培养,显微镜下观察细胞形态,并

  4. 辨证取穴配合刺络拔罐治疗带状疱疹疗效观察%Observation of curative effect of herpes zoster treated with acupuncture based on syndrome differentiation combined with pricking and cupping

    Institute of Scientific and Technical Information of China (English)

    潘华

    2011-01-01

    目的:比较辨证取穴配合刺络拔罐法与单纯刺络拔罐法治疗带状疱疹的疗效差异.方法:将86例患者随机分为观察组(43例)、对照组(43例).观察组采用辨证取穴配合局部刺络拔罐治疗,分为肝胆湿热型、脾虚湿蕴型、气虚血瘀型,穴取曲池、足三里、三阴交等;对照组采用单纯局部刺络拔罐法.两组每日1次,7天为一疗程,2个疗程后统计疗效,1月后随访.结果:观察组愈显率为93.0%(40/43),优于对照组的67.4%(29/43)(P<0.01).后遗神经痛:观察组发生率2.3%(1/43),对照组14.0%(6/43),观察组低于对照组(P<0.05).分型比较:肝胆湿热型愈显率:观察组94.7%(18/19),对照组85.7%(18/21),差异无统计学意义(P>0.05);脾虚湿蕴型愈显率:观察组93.8%(15/16),优于对照组60.0%(9/15)(P<0.05);气虚血瘀型愈显率:观察组87.5%(7/8),明显优于对照组的28.6%(2/7)(P<0.05).结论:辨证取穴配合刺络拔罐治疗带状疱疹,针对性强、疗效明显,可显著减少后遗神经痛,疗效优于单纯刺络拔罐法.%Objective To compare the differences of curative effects of herpes zoster treated with acupuncture based on syndrome differentiation combined with pricking and cupping and simple pricking and cupping. Methods Eighty-six cases were randomly divided into an observation group (43 cases) and a control group (43 cases). In observation group, acupoints selection based on syndrome differentiation I.e. Quchi( LI 11), ZusanlKST 36), Sanyinjiao ( SP 6), etc. Were selected and pricking and cupping at affected parts were applied, and the cases were classified into damp heat in liver and gallbladder, damp retention and spleen deficiency, and qi deficiency and blood stasis. In control group, all the cases were simplely treated with pricking and cupping at affected parts. The treatment was given once a day, and seven days were made one session. The curative effect was evaluated after 2 courses, and the

  5. Blindness resulting from orbital complications of ophthalmic zoster

    Science.gov (United States)

    Sosnowska, Magdalena; Zajkowska, Agata; Garkowski, Adam; Czupryna, Piotr; Pancewicz, Sławomir; Zajkowska, Joanna

    2015-01-01

    Herpes zoster ophthalmicus occurs when the latent varicella zoster virus (VZV) reactivates in the trigeminal ganglion and ophthalmic branch of the trigeminal nerve. In the elderly, there is a sharp increase in the tendency of secondary skin bacterial infections occurrence due to the deterioration of capabilities of self-care and changed sanitation. We present a case of patient who developed phlegmon of the orbit, which resulted with complete unilateral blindness. Varicella zoster virus infection in the elderly may have a severe course due to the progressive weakening of the immune system related to the age. Moreover, skin lesions around the eye socket require special care in prevention of bacterial superinfections due to the extremely high risk of life-threatening complications or disability. Neuralgia resistant to pharmacological treatment present in the course of ophthalmic zoster and difficulty in caring about skin lesions predispose to the occurrence of complications. PMID:26759550

  6. Herpes Simplex

    Science.gov (United States)

    ... cold sores caused by HSV-1 are: Oral herpes. Mouth herpes. Herpes simplex labialis. A closely related herpes ... call this “asymptomatic viral shedding.” How people get herpes around their mouth A person with HSV-1 (herpes simplex type ...

  7. Zoster vaccine live for the prevention of shingles in the elderly patient

    Directory of Open Access Journals (Sweden)

    Jamie Zussman

    2008-06-01

    Full Text Available Jamie Zussman, Lorraine YoungDepartment of Medicine, Dermatology Division, David Geffen School of Medicine at the University of California, Los Angeles, CaliforniaAbstract: Shingles, also known as herpes zoster, is a common disease in the elderly population that is caused by reactivation of latent varicella zoster virus. Its manifestations and complications can lead to significant short- and long-term morbidity. In 2006, the United States Food and Drug Administration approved Zoster Vaccine Live (Zostavax® for the prevention of herpes zoster in immunocompetent adults age 60 and over. The approval was based on the results of a large, multi-center clinical trial, the Shingles Prevention Study. This study showed that vaccination significantly decreased shingles incidence, burden of illness due to disease, and the development of, and severity of postherpetic neuralgia. This review offers an overview of varicella zoster virus infection and complications, a summary of the Shingles Prevention Study, and a critical analysis designed to aid the practicing physician who has questions about vaccine administration.Keywords: zoster vaccine, shingles, herpes zoster, postherpetic neuralgia, zostavax

  8. Adaptive Immune Responses in a Multiple Sclerosis Patient with Acute Varicella-Zoster Virus Reactivation during Treatment with Fingolimod

    Directory of Open Access Journals (Sweden)

    Andrea Harrer

    2015-09-01

    Full Text Available Fingolimod, an oral sphingosine 1-phosphate (S1P receptor modulator, is approved for the treatment of relapsing forms of multiple sclerosis (MS. The interference with S1P signaling leads to retention particularly of chemokine receptor-7 (CCR7 expressing T cells in lymph nodes. The immunological basis of varicella zoster virus (VZV infections during fingolimod treatment is unclear. Here, we studied the dynamics of systemic and intrathecal immune responses associated with symptomatic VZV reactivation including cessation of fingolimod and initiation of antiviral therapy. Key features in peripheral blood were an about two-fold increase of VZV-specific IgG at diagnosis of VZV reactivation as compared to the previous months, a relative enrichment of effector CD4+ T cells (36% versus mean 12% in controls, and an accelerated reconstitution of absolute lymphocytes counts including a normalized CD4+/CD8+ ratio and reappearance of CCR7+ T cells. In cerebrospinal fluid (CSF the lymphocytic pleocytosis and CD4+/CD8+ ratios at diagnosis of reactivation and after nine days of fingolimod discontinuation remained unchanged. During this time CCR7+ T cells were not observed in CSF. Further research into fingolimod-associated VZV reactivation and immune reconstitution is mandatory to prevent morbidity and mortality associated with this potentially life-threatening condition.

  9. Recurrent facial urticaria following herpes simplex labialis.

    Science.gov (United States)

    Zawar, Vijay; Godse, Kiran

    2012-03-01

    We describe recurrent acute right-sided facial urticaria associated with herpes labialis infection in a middle-aged female patient. Antiviral medications and antihistamines not only successfully cleared the herpes infection and urticaria but also prevented further recurrences.

  10. Recurrent facial urticaria following herpes simplex labialis

    OpenAIRE

    Vijay Zawar; Kiran Godse

    2012-01-01

    We describe recurrent acute right-sided facial urticaria associated with herpes labialis infection in a middle-aged female patient. Antiviral medications and antihistamines not only successfully cleared the herpes infection and urticaria but also prevented further recurrences.

  11. Sero-Prevalence of Antibodies against Varicella Zoster Virus in Children under Seven-Years Old in 2012 in Tehran, Iran.

    OpenAIRE

    Yasaman Vojgani; Saeed Zarei; Samira Rajaei; Leili Chamani-Tabriz; Fatemeh Ghaemimanesh; Nematallah Mohammadinia; Mahmood Jeddi-Tehrani

    2014-01-01

    Abstract Background Varicella zoster virus (VZV) is a member of herpes family viruses, which causes varicella (chickenpox) after primary infection and herpes zoster (shingles) because of latent virus reactivation from dorsal root ganglia. Generally, prevalence of varicella antibodies increases with age. We aimed to compare the prevalence of anti-VZV antibody in children under seven years old, in order to obtain a preliminarily picture of general presence of these antibodies to design an immun...

  12. Acute Morphine Administration Reduces Cell-Mediated Immunity and Induces Reactivation of Latent Herpes Simplex Virus Type 1 in BALB/c Mice

    Institute of Scientific and Technical Information of China (English)

    Shafi Mojadadi; Abbas Jamali; Behzad Khansarinejad; Hoorieh Soleimanjahi; Taravat Bamdad

    2009-01-01

    Acute morphine administration is known to alter the course of herpes simplex virus infection. In this study, the effect of acute morphine administration on the reactivation of latent herpes was investigated in a mouse model. Because of the important role of cytolytic T lymphocyte (CTL) activity in the inhibition of herpes simplex virus type 1 (HSV-1) reactivation, the effect of acute morphine administration on CTL responses was also evaluated. Furthermore, lymphocyte proliferation and IFN-γ production were evaluated for their roles in the induction of the CTL response. The findings showed that acute morphine administration significantly reduced CTL responses, lymphocyte proliferation, and IFN-γ production. Furthermore, acute morphine administration has been shown to reactivate latent HSV-1. Previous studies have shown that cellular immune responses have important roles in the inhibition of HSV reactivation. These findings suggest that suppression of a portion of the cellular immune response after acute morphine administration may constitute one part of the mechanism that induces HSV reactivation. Cellular & Molecular Immunology.

  13. Prolonged varicella-zoster virus reinfection in an adult after unrelated cord blood transplantation

    Directory of Open Access Journals (Sweden)

    Masahiro Oka

    2012-01-01

    Full Text Available Most varicella-zoster virus (VZV infections after cord blood transplantation (CBT present as localized herpes zoster. Here, we report a case of VZV reinfection in an adult patient after CBT that appeared clinically to be varicella. A 50-year-old Japanese man underwent CBT for the management of acute lymphoblastic leukemia. Seventeen months later, he developed a small number of vesicles with umbilicated centers. A skin biopsy showed an intraepidermal blister containing degenerated balloon cells. Subsequently, the skin eruption developed over his entire body. The patient was treated with intravenous acyclovir for 5 days, followed by oral valacyclovir for 9 days. It took more than 3 weeks for most of the skin lesions to scab. Serum levels of anti-VZV IgG on days 3 and 33 after the onset of the skin eruption were negative and 260 mIU/ml, respectively. Serum anti-VZV IgM on days 3 and 33 was not detected. Our patient was diagnosed with VZV reinfection.

  14. Effect of acyclovir combined with narrow-band ultraviolet-B radiation and Carnation 33 NM-B in treating immunocompromised host with herpes zoster%阿昔洛韦联合高能红光和窄谱中波紫外线治疗免疫功能下降带状疱疹患者的疗效观察

    Institute of Scientific and Technical Information of China (English)

    陈胜平; 陈锦华; 陈向齐; 吴洁; 牛高祥

    2013-01-01

      Objective To compare the effect of acyclovir combined with narrow-band ultraviolet-B radiation (NB-UVB) and Carnation 33 NM-B with that of acyclovir in the treatment of herpes zoster in immunocompromised patients. Methods Sixty-four immunocompromised patients with herpes zoster were divided into two groups, test group and control group randomly. The test group was treated with acyclovir combined with NB-UVB and the Carnation 33 NM-B;while the control group was treated with acyclovir. The efficacy was observed 14 days after treatment and the follow-up had been carried out for more than 1 months. Results The effective rate was 90.63%in the test group versus 68.75%in the control group (P=0.011). The effect of test group on vesicular scab, subside, pain relief and pain complete remission time was superior to that of the control group (P0.05). Conclusion The treatment with acyclovir combined with NB-UVB and the Carnation 33 NM-B is superior to acyclovir in immunocompromised patients with herpes zoster.%  目的比较阿昔洛韦联合高能红光和窄谱中波紫外线与单用阿昔洛韦治疗免疫功能下降带状疱疹患者的疗效,寻求一种更好的治疗方法。方法64例免疫功能下降带状疱疹患者随机分为试验组和对照组。试验组采用阿昔洛韦静脉滴注联合高能红光照射支配皮损区域的神经根体表投射部位和窄谱中波紫外线照射皮损局部,对照组单独静脉滴注阿昔洛韦,疗程均为14 d,随访1个月。结果试验组有效率为90.63%,高于对照组(68.75%)(P=0.011);试验组开始结痂时间、结痂脱落时间、疼痛开始缓解时间、疼痛基本缓解时间均低于对照组(P<0.001)。两组患者止疱时间、后遗神经痛发生率比较,差异无统计学意义(P>0.05)。结论阿昔洛韦联合高能红光和窄谱中波紫外线治疗免疫功能下降并发带状疱疹患者的疗效优于单用阿昔洛韦者。

  15. Effects of nerve block combined with antiviral drug on patients with herpes zoster pain and sleep quality%神经阻滞联合抗病毒药物对带状疱疹患者疼痛及睡眠质量影响

    Institute of Scientific and Technical Information of China (English)

    陈慧

    2015-01-01

    Objective To explore the nerve block combined with antiviral drug on patients with herpes zoster treatment effect,and provide the basis for clinical pain relief and improve the quality of sleep.Methods The 90 cases of herpes zoster patients in our hospital in the Department of Dermatology for treatment,30 cases were randomly divided into a,B,C 30 cases 30 cases,group A with simple antiviral therapy,group B with antiviral joint pain relieving antiphlogistic drug therapy,group C treated with nerve block combined with antiviral therapy,recording three groups of visual score (VAS) and sleep quality score (QS),analysis and improvement in three groups of pain and sleep quality.Results The pain scores before and after treatment,in group A had no obvious change for the better,after 2 weeks,will be obviously significant differences (t =4.329,5.424,P < 0.05),C B two groups in 1 weeks after treatment there were significant differences (P < 0.05).In sleep quality,sleep quality has not improved significantly in group A (P >0.05),after 1 weeks,the sleep quality improvement (P < 0.05) before and after treatment in the two groups of ethylene and propylene,there was significant difference (P < 0.05),ethylene propylene no obvious differences between the two groups (P > 0.05).Conclusions The nerve block combined with antiviral drug with good pain relief and improve the role of sleep in patients with herpes zoster,can be used in clinical treatment.%目的 探究神经阻滞联合抗病毒药物对带状疱疹患者治疗效果,为临床疼痛缓解和改善睡眠质量提供依据.方法 选用来我院神经内科就诊带状疱疹患者90例,随机分为甲30例、乙30例、丙30例,甲组采用单纯抗病毒治疗,乙组采用抗病毒联合镇痛消炎药治疗,丙组采用神经阻滞联合抗病毒治疗,记录三组视觉评分(VAS)和睡眠质量评分(QS),分析三组疼痛和睡眠质量改善情况.结果 疼痛评分上,甲组治疗前后未见明显好转,2

  16. Varicella-zoster virus: pathogenesis, incidence patterns and vaccination programs.

    Science.gov (United States)

    Gabutti, Giovanni; Franchi, Michele; Maniscalco, Licia; Stefanati, Armando

    2016-06-01

    Varicella or chickenpox is a common and highly contagious exanthematic disease caused by the varicella-zoster virus (VZV) that during primary infection has the ability to establish latency. VZV reactivation, even decades after primary infection, causes herpes zoster. In healthy immunocompetent subjects, children in particular, varicella results in mild to moderate illness and for this reason, regardless its high morbidity, it is not considered a public health priority. Varicella still represents the most widespread vaccine preventable childhood infectious disease in industrialized countries; due to its relevant burden on healthcare resources several countries has introduced varicella vaccination into the recommended routine childhood national immunization schedule. Nowadays, live attenuated monovalent and combined MMRV vaccines are licensed worldwide. The use of several millions of doses has demonstrated the excellent safety and efficacy level of varicella vaccines as well as of combined MMRV vaccines. Universal vaccination adopted in many countries with a two-dose strategy has allowed to significantly reducing morbidity and mortality of this infectious disease. Anyway, an ample international debate is ongoing on the time range to be used between the two doses, and on the safety issues related to the use as first-dose of MMRV vaccine. Taking into account the availability of a zoster vaccine in subjects older than 50 years of age, it will be relevant to clarify if an impact on exogenous boosters and on the epidemiology of herpes zoster can occur after the adoption of extensive varicella immunization.

  17. Corticosteroid therapy of zoster-associated pain

    Directory of Open Access Journals (Sweden)

    Cvjetković Dejan M.

    2004-01-01

    Full Text Available Introduction Lack of exact clinical studies on effects of corticosteroids in therapy and prevention of herpes zoster-related pain, elicited many controversies in the past. The aim of our study was to estimate effects of prednisone on frequency, intensity and duration of postherpetic neuralgia. Material and methods 68 immunocompetent herpes zoster patients, 8-90 years of age (37 females and 31 males, mean age 55,7 years were enrolled for study; 30 patients were treated with acyclovir (5x800 mg daily for a 7-day period and prednisone (initial daily dose 60 mg, tapering over 14 days, and the control group of 38 patients with acyclovir only. Patients were clinically followed up for 3 months after complete resolution of skin lesions. Chi-square test was used in statistical data analysis. Results The difference regarding incidence of postherpetic neuralgia in acyclovir/prednisone group and acyclovir group (although slightly less in the former one was not significant. Duration of postherpetic neuralgia over 3 months was similar in both groups. Mild postherpetic pain was more common in the acyclovir/prednisone group (44.4% than in the acyclovir group (28.6%; however, statistical validation requires more patients to be studied. Discussion Results of our study didn’t confirm efficiency of prednisone regarding occurrence and characteristics of postherpetic neuralgia. Failure of prednisone therapy may be partly contributed to advanced age of patients and delayed onset of therapy. Conclusion Use of corticosteroids in zoster patients gives neither reliable protection from appearance of postherpetic neuralgia, nor shortens its duration. Further investigations are necessary to estimate their effects on postherpetic pain.

  18. Complications of varicella zoster.

    Science.gov (United States)

    Gücüyener, Kivilcim; Citak, Elvan Cağlar; Elli, Murat; Serdaroğlu, Ayse; Citak, Funda Erkasar

    2002-02-01

    Primary infection with varicella zoster is characterzed by a generalized vesicular rash usually without significant systemic illness. Encephalitis, pneumonitis, pancreatitis, nephritis, Reye and Guillan-Barre syndrome transvers myelitis, myocarditis have been reported before, but there is not any case having all these system to be involved during the same infection in a sequential manner ending up with multiorgan failure. We wanted to represent 21-month-old boy had a multiorgan failure due to varicella zoster infection.

  19. 梅花针配合拔罐治疗带状疱疹及后遗神经痛33例%Zoster and postherpetic neuralgia treated by percussopunctato combined with cupping therapy 33 cases

    Institute of Scientific and Technical Information of China (English)

    韩利民; 赵树林

    2003-01-01

    @@ BACKGROUND: If the zoster patients were not treated properly or failed to be cured in time, secondary infection or postherpetic neuralgia may appeared. Severe pain might exist for years although the herpes recovered completely.

  20. Optimal management of genital herpes: current perspectives

    Directory of Open Access Journals (Sweden)

    Sauerbrei A

    2016-06-01

    Full Text Available Andreas Sauerbrei Institute of Virology and Antiviral Therapy, German Consulting Laboratory for Herpes Simplex Virus and Varicella-Zoster Virus, Jena University Hospital, Friedrich-Schiller University of Jena, Jena, Germany Abstract: As one of the most common sexually transmitted diseases, genital herpes is a global medical problem with significant physical and psychological morbidity. Genital herpes is caused by herpes simplex virus type 1 or type 2 and can manifest as primary and/or recurrent infection. This manuscript provides an overview about the fundamental knowledge on the virus, its epidemiology, and infection. Furthermore, the current possibilities of antiviral therapeutic interventions and laboratory diagnosis of genital herpes as well as the present situation and perspectives for the treatment by novel antivirals and prevention of disease by vaccination are presented. Since the medical management of patients with genital herpes simplex virus infection is often unsatisfactory, this review aims at all physicians and health professionals who are involved in the care of patients with genital herpes. The information provided would help to improve the counseling of affected patients and to optimize the diagnosis, treatment, and prevention of this particular disease. Keywords: herpes simplex virus, epidemiology, infection, antiviral therapy, laboratory diagnosis, prevention

  1. Herpes - oral

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/000606.htm Herpes - oral To use the sharing features on this page, ... 374. Read More Atopic dermatitis Cancer Fever Genital herpes Mouth ulcers Vesicles Review Date 8/14/2015 Updated ...

  2. Management of ramsay hunt syndrome in an acute palliative care setting

    Directory of Open Access Journals (Sweden)

    Shrenik Ostwal

    2015-01-01

    Full Text Available Introduction: The Ramsay Hunt syndrome is characterized by combination of herpes infection and lower motor neuron type of facial nerve palsy. The disease is caused by a reactivation of Varicella Zoster virus and can be unrepresentative since the herpetic lesions may not be always be present (zoster sine herpete and might mimic other severe neurological illnesses. Case Report: A 63-year-old man known case of carcinoma of gall bladder with liver metastases, post surgery and chemotherapy with no scope for further disease modifying treatment, was referred to palliative care unit for best supportive care. He was on regular analgesics and other supportive treatment. He presented to Palliative Medicine outpatient with 3 days history of ipsilateral facial pain of neuropathic character, otalgia, diffuse vesciculo-papular rash over ophthalmic and maxillary divisions of left trigeminal nerve distribution of face and ear, and was associated with secondary bacterial infection and unilateral facial edema. He was clinically diagnosed to have Herpes Zoster with superadded bacterial infection. He was treated with tablet Valacyclovir 500 mg four times a day, Acyclovir cream for local application, Acyclovir eye ointment for prophylactic treatment of Herpetic Keratitis, low dose of Prednisolone, oral Amoxicillin and Clindamycin for 7 days, and Pregabalin 150 mg per day. After 7 days of treatment, the rash and vesicles had completely resolved and good improvement of pain and other symptoms were noted. Conclusion: Management of acute infections and its associated complications in an acute palliative care setting improves both quality and length of life.

  3. Acute Interstitial Nephritis Proteinuria and Herpes Simplex Virus Hepatitis in Pregnancy Mimic HELLP Syndrome (Hemolysis, Elevated Liver Enzymes, Low Platelets

    Directory of Open Access Journals (Sweden)

    Wendy M. White

    2011-12-01

    Full Text Available Elevated transaminases, hemolysis, and thrombocytopenia in pregnancy are most often caused by a preeclampsia variant—HELLP syndrome (hemolysis, elevated liver enzymes, low platelets. In atypical cases, it is important to consider other causes, such as herpes simplex virus (HSV hepatitis. Acute interstitial nephritis (AIN-induced proteinuria can make distinguishing HELLP from its mimics more difficult. A 43-year-old G4P3 gestational carrier at 28 weeks had abnormal laboratory findings consistent with HELLP, including proteinuria. However, she was normotensive and febrile, prompting an investigation into other possible causes of her signs and symptoms. She ultimately was diagnosed with disseminated HSV infection, started on definitive therapy, and allowed to continue her pregnancy to term. The proteinuria was attributed to AIN. AIN can cause proteinuria in the critically ill pregnant patient. When mimics of HELLP syndrome, such as disseminated HSV infection, are the cause of critical illness, the presence of AIN-induced proteinuria may falsely implicate a hypertensive disorder of pregnancy, resulting in iatrogenic premature delivery of the fetus and failure to initiate definitive potential lifesaving treatment.

  4. Varicella zoster meningitis complicating combined anti-tumor necrosis factor and corticosteroid therapy in Crohn's disease.

    Science.gov (United States)

    Ma, Christopher; Walters, Brennan; Fedorak, Richard N

    2013-06-01

    Opportunistic viral infections are a well-recognized complication of anti-tumor necrosis factor (TNF) therapy for inflammatory bowel disease (IBD). Cases of severe or atypical varicella zoster virus infection, both primary and latent reactivation, have been described in association with immunosuppression of Crohn's disease (CD) patients. However, central nervous system varicella zoster virus infections have been rarely described, and there are no previous reports of varicella zoster virus meningitis associated with anti-TNF therapy among the CD population. Here, we present the case of a 40-year-old male with severe ileocecal-CD who developed a reactivation of dermatomal herpes zoster after treatment with prednisone and adalimumab. The reactivation presented as debilitating varicella zoster virus meningitis, which was not completely resolved despite aggressive antiviral therapy with prolonged intravenous acyclovir and subsequent oral valacyclovir. This is the first reported case of opportunistic central nervous system varicella zoster infection complicating anti-TNF therapy in the CD population. This paper also reviews the literature on varicella zoster virus infections of immunosuppressed IBD patients and the importance of vaccination prior to initiation of anti-TNF therapy.

  5. Epidemiological characteristics and societal burden of varicella zoster virus in the Netherlands

    Directory of Open Access Journals (Sweden)

    Pierik Jorien GJ

    2012-05-01

    Full Text Available Abstract Background Varicella and herpes zoster are both caused by varicella zoster virus (VZV infection or reactivation and may lead to complications associated with a (severe societal burden. Because the epidemiology of VZV-related diseases in the Netherlands remains largely unknown or incomplete, the main objective of this study was to study the primary care incidence, associated complications and health care resource use. Methods We investigated the incidence of VZV complications in the Dutch general practitioner (GP practices and pharmacies in a retrospective population-based cohort study (2004–2008 based on longitudinal GP data including free text fields, hospital referral and discharge letters from approximately 165,000 patients. Results The average annual incidence of varicella GP-consultations was 51.5 per 10,000 (95% CI 44.4-58.7 overall; 465.5 per 10,000 for 0–1 year-olds; 610.8 per 10,000 for 1–4 year-olds; 153.5 per 10,000 for 5–9 year-olds; 8,3 per 10,000 for >10 year olds. When only ICPC coded diagnoses were analyzed the incidence was 27% lower. The proportion of complications among varicella patients was 34.9%. Most frequently complications were upper respiratory tract infections. Almost half of the varicella patients received medication. The referral rate based on GP consultations was 1.7%. The average annual incidence of herpes zoster GP-consultations was 47.5 per 10,000 (95% CI 40.6-54.4. The incidence increased with age; 32.8 per 10,000 for 65 year olds. When estimating herpes zoster incidence only on ICPC coded information, the incidence was 28% lower. The complication rate of herpes zoster was 32.9%. Post herpetic neuralgia was seen most often. Of patients diagnosed with herpes zoster 67.8% received medication. The referral rate based on GP consultations was 3.5%. Conclusions For varicella the highest incidence of GP-consultations was found in 1–4 year-olds, for herpes zoster in the >65 years olds

  6. 点刺拔罐配合氦氖激光联合药物治疗早期带状疱疹的临床观察%Venesection Ventouse Coordinated with Helium-neon Laser Combined with Drugs Treat Early Herpes Zoster

    Institute of Scientific and Technical Information of China (English)

    马荣; 陈宏

    2015-01-01

    Objective]Observe the clinical effect of early herpes zoster which were treated by venesection ventouse combined with helium-neon laser and drugs. [Methods]The control group 32 cases used Famciclovir Tablet,transfer factor capsules,mecobalamin and acyclovir cream-drug for external use. While the experimental group 32 cases used Famciclovir Tablet,transfer factor capsules,mecobalamin and acyclovir cream-drug for external use. While the experimental group besides taking above-medicine, were treated with venesection ventouse and helium-neon laser at the pathological change. [Results]The control group used to cure for an average of 13 ±2.5 days. The experimental group used to cure for an average of 9.6 ±2.4 days. There were significant differences(P<0.05). [Conclusion] Early herpes zoster treated by venesection ventouse combined with helium-neon laser and drugs, can significantly shorten the duration of symptoms, alleviate suffering, and has good clinical efficacy.%[目的]观察点刺拔罐配合氦氖激光联合药物治疗早期带状疱疹的临床疗效。[方法]选取天津市长征医院2013年5月至2013年10月皮肤科门诊就诊的早期带状疱疹患者64例,按其就诊的先后顺序随机分为实验组32例和对照组32例,对照组给予口服药泛昔洛韦片、转移因子胶囊、甲钴胺片及外用药阿昔洛韦软膏;实验组32例,在对照组治疗基础上再施以点刺拔罐配合氦氖激光辅助治疗。运用统计学分析两组患者的平均治愈时间。[结果]对照组达到治愈所用的平均时间为13±2.5天,实验组达到治愈所用的平均时间为9.6±2.4天,实验组优于对照组,差异有统计学意义(P<0.05)。[结论]运用点刺拔罐配合氦氖激光联合药物治疗早期带状疱疹可以明显缩短病程、减轻病痛,有较好的临床疗效。

  7. 牛痘疫苗致炎兔皮提取物注射液联合阿昔洛韦治疗老年带状疱疹的临床观察%Clinical Observation of Extracts from Rabbit Skin Inflamed by Vaccinia Virus for Injection Combined with Acyclovir in the Treatment of Senile Herpes Zoster

    Institute of Scientific and Technical Information of China (English)

    刘国海; 张贵田; 刘庆明

    2013-01-01

    目的:观察牛痘疫苗致炎兔皮提取物注射液联合阿昔洛韦治疗老年带状疱疹的疗效和安全性.方法:将120例患者均分成治疗组和对照组,治疗组给予牛痘疫苗致炎兔皮提取物注射液、阿昔洛韦、维生素B1、维生素B12联合治疗;对照组给予阿昔洛韦、维生素B1、维生素B12常规治疗,观察两组止疱时间、止痛时间、结痂时间、痊愈时间;并于治疗前及治疗第3、7、10天进行疼痛视觉模拟评分(VAS)评价,治疗过程中观察患者不良反应发生情况.结果:治疗组的止疱时间、止痛时间、结痂时间、痊愈时间、VAS评分等方面均优于对照组(P<0.05).两组均未见明显不良反应发生.结论:牛痘疫苗致炎兔皮提取物注射液联合阿昔洛韦治疗老年带状疱疹疗效较好、安全性较高,可明显减少后遗神经痛.%OBJECTIVE: To observe therapeutic efficacy and safety of Extracts from rabbit skin inflamed by vaccinia virus for injection (analgecine) combined with acyclovir in the treatment of senile herpes zoster. METHODS: 120 patients were randomly divided into treatment group and control group; treatment group received analgecine, acyclovir, vitamin B1 and vitamin B12, and control group was given conventional treatment of acyclovir, vitamin B1 and vitamin B12. The time of response and analgesia, duration of lesion clearance and recovery time were observed in 2 groups. Pain visual analog scale (VAS) evaluation was conducted before treatment, 3, 7 and 10 days after treatment. The adverse drug reaction in the treatment were observed. RESULTS: The time of response and analgesia, duration of lesion clearance and recovery time in treatment group were better than in control group (P< 0.05). VAS scores decreased significantly. There was no significant ADR found in both groups. CONCLUSION: Analgecine combined with acyclovir is effective in the treatment of herpes zoster, and can significantly reduce postherpetic

  8. Animal Models of Varicella Zoster Virus Infection

    Directory of Open Access Journals (Sweden)

    Ilhem Messaoudi

    2013-05-01

    Full Text Available Primary infection with varicella zoster virus (VZV results in varicella (chickenpox followed by the establishment of latency in sensory ganglia. Declining T cell immunity due to aging or immune suppressive treatments can lead to VZV reactivation and the development of herpes zoster (HZ, shingles. HZ is often associated with significant morbidity and occasionally mortality in elderly and immune compromised patients. There are currently two FDA-approved vaccines for the prevention of VZV: Varivax® (for varicella and Zostavax® (for HZ. Both vaccines contain the live-attenuated Oka strain of VZV. Although highly immunogenic, a two-dose regimen is required to achieve a 99% seroconversion rate. Zostavax vaccination reduces the incidence of HZ by 51% within a 3-year period, but a significant reduction in vaccine-induced immunity is observed within the first year after vaccination. Developing more efficacious vaccines and therapeutics requires a better understanding of the host response to VZV. These studies have been hampered by the scarcity of animal models that recapitulate all aspects of VZV infections in humans. In this review, we describe different animal models of VZV infection as well as an alternative animal model that leverages the infection of Old World macaques with the highly related simian varicella virus (SVV and discuss their contributions to our understanding of pathogenesis and immunity during VZV infection.

  9. Effect of Compound Shenqi Vitamin E Capsules Combined with Famciclovir on Immune Function in Patients with Herpes Zoster%复方参芪维E胶囊联合泛昔洛韦对带状疱疹患者免疫功能的影响

    Institute of Scientific and Technical Information of China (English)

    郝燕生; 杨玉明

    2014-01-01

    目的:探讨复方参芪维 E 胶囊联合泛昔洛韦对带状疱疹患者免疫功能的影响。方法将124例患者随机分为两组,各62例。对照组患者应用泛昔洛韦治疗,同时肌肉注射干扰素α-2b,持续用药7 d;观察组开始用药同对照组,停药后口服复方参芪维 E 胶囊,持续用药10 d。对比分析两组患者临床疗效及症状缓解时间,治疗前后应用流式细胞仪测定两组 T 淋巴细胞亚群。结果观察组总有效率为93.55%,明显高于对照组的77.42%( P <0.05)。观察组止疱、结痂、疼痛缓解、脱痂时间均明显短于对照组( P <0.05)。观察组治疗后CD +3,CD4+,CD4+/ CD +8水平显著高于对照组,而CD +8水平则低于对照组( P <0.05)。观察组后遗神经痛发生率为0(0/62),低于对照组的8.06%(5/62),两组比较有统计学差异( P <0.05)。结论复方参芪维 E 胶囊联合泛昔洛韦治疗带状疱疹,能有效提高疗效,缓解临床症状,且能有效预防后遗神经痛的发生,同时可提高患者的免疫功能。%Objective To investigate the effect of Compound Shenqi Vitamin E Capsules combined with famciclovir on the immune func-tion in the patients with herpes zoster. Methods 124 cases of herpes zoster were randomly divided into the observation group( n = 62) and the control group( n = 62). The control group simultaneously applied famciclovir and intramuscular injection of interferon for continu-ous 7 d;while at the beginning the medication in the observation group was same to the control group,after drug withdrawal oral Compound Shenqi Vitamin E Capsules was given for continuous 10 d. The clinical effects and the symptom remission time were com-pared between the two groups. The levels of CD4+ T lymphocyte subsets before and after treatment in the two groups were detected by the flow cytometry. Results The total effective rate of observation group was 93. 55% ,which was higher than

  10. Clinical study of liquid nitrogen cryotherapy combined with acyclovir and mecobalamin in elderly patients with herpes zoster%液氮冷冻疗法联合阿昔洛韦片及甲钴胺分散片治疗老年人带状疱疹临床观察

    Institute of Scientific and Technical Information of China (English)

    曹鸿玮; 王菲菲; 杨俊亚; 王瑞; 郑晓红

    2014-01-01

    目的 探讨液氮冷冻疗法联合阿昔洛韦片、甲钴胺分散片口服治疗老年人带状疱疹的疗效和安全性. 方法 将520例老年人带状疱疹患者随机数字表法分为试验组和对照组,每组各260例,对照组患者口服阿昔洛韦片和甲钴胺分散片治疗,试验组在对照组用药的基础上加用液态氮冷冻治疗,用棉签蘸取液氮在皮损处轻擦,1次/d,共5次.在治疗的第5、14、30天随访患者,观察两组患者是否有新水疱出现、干燥、结痂情况,记录皮疹止疱时间、结痂时间、结痂脱落时间、疼痛消退时间和后遗神经痛(postherpetic neuralgia,PHN)情况. 结果 试验组有效率为93.9%(244/260),高于对照组84.2%(219例),差异有统计学意义(x2=12.32,P<0.05).试验组患者结痂、水疱干燥、疼痛消退时间分别为(2.6±0.8)d、(8.2±1.7)d、(9.2±2.5)d,均低于对照组(4.8±1.4)d,(11.3±2.2)d,(12.8±3.1)d(均P<0.01).试验组止疱时间(1.9±0.6)d与对照组(1.8±0.8)d比较,差异无统计学意义(t=0.933,P>0.05).试验组患者后遗神经痛发生率6.9%(18/260),与对照组患者后遗神经痛发生率18.1%(47/260),差异有统计学意义(x2=14.787,P<0.01). 结论 液氮冷冻联合阿昔洛韦片、甲钴胺分散片口服疗效优于阿昔洛韦片、甲钴胺分散片口服治疗,试验组具有水疱干燥、结痂时间缩短、疼痛消退快、后遗神经痛发生减少的优点.%Objective To compare the efficacy and safety of liquid nitrogen cryotherapy combined with acyclovir and mecobalamin in the treatment of herpes zoster in elderly patients.Methods 520 elderly patients with herpes zoster were randomly divided into two groups,experimental group and control group (n=260,each).Patients in experimental group were treated with liquid nitrogen cryotherapy,using liquid nitrogen cotton swab to graze the skin lesions 2-3 times per day for successive 5 days,combined with acyclovir and mecobalamin.Patients in control

  11. Severe autoimmune hepatitis triggered by varicella zoster infection

    Institute of Scientific and Technical Information of China (English)

    Waleed K Al-Hamoudi

    2009-01-01

    Autoimmune hepatitis (AIH) is a chronic disease of unknown etiology that is characterized by the presence of circulatory autoantibodies and inflammatory histological changes in the liver. Although the pathogenesis of AIH is not known, it is thought that,in a genetically predisposed individual, environmental factors such as viruses can trigger the autoimmune process. Herpes simplex virus, Epstein-Barr virus,measles virus, and hepatitis viruses are thought to play a role in the etiology of AIH. Proteins belonging to these viruses may be similar to the amino acid chains of different autoantigens in the liver, this causes immune cross reactions and liver tissue damage. We report a case of severe AIH following varicella zoster infection in a 23-year-old man, and speculate that,based on the molecular mimicry hypothesis, the liver damage was caused by an immune cross reaction to the viral proteins. Varicella-zoster-induced AIH has not been reported previously.

  12. Topical cidofovir-induced acute kidney injury in two severely immunocompromised patients with refractory multidrug-resistant herpes simplex virus infections.

    Science.gov (United States)

    Saunders, Ila M; Lahoti, Amit; Chemaly, Roy F; Trevino, Cynthia; Westmoreland, Michael; Hosing, Chitra

    2016-04-01

    Cidofovir, a nucleoside analog of deoxycytidine monophosphate, is a water-soluble polar molecule that exhibits antiviral activity against a broad range of DNA viruses. Cidofovir for injection is approved for the treatment of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome. The safety and efficacy of topical cidofovir has been described in a limited number of patients. We present two cases of multidrug-resistant herpes simplex virus infections that responded to topical cidofovir therapy yet resulted in irreversible acute kidney injury.

  13. VARICELLA ZOSTER VIRUS-ITS PATHOGENESIS, LATENCY & CELL-MEDIATED IMMUNITY

    Directory of Open Access Journals (Sweden)

    Anis Ahmed

    2013-07-01

    Full Text Available Varicella zoster virus causes primary infection as chickenpox, at which time latencyis established in the neurons of the dorsal root ganglia or ganglia of the cranial nerves.Reactivation produces herpes zoster infection (HZI, commonly called shingles. Anunderstanding of the mechanisms of latency is crucial in developing effective therapies forVZV infections of the nervous system. This article describes the pathogenesis of VZVwhich includes immune response to the virus, immune evasion by the virus, mechanism ofits latency and cell-mediated immunity.

  14. Varicella zoster virus-induced pain and post-herpetic neuralgia in the human host and in rodent animal models.

    Science.gov (United States)

    Kinchington, Paul R; Goins, William F

    2011-12-01

    Pain and post-herpetic neuralgia (PHN) are common and highly distressing complications of herpes zoster that remain a significant public health concern and in need of improved therapies. Zoster results from reactivation of the herpesvirus varicella zoster virus (VZV) from a neuronal latent state established at the primary infection (varicella). PHN occurs in some one fifth to one third of zoster cases with severity, incidence, and duration of pain increasing with rising patient age. While VZV reactivation and the ensuing ganglionic damage trigger the pain response, the mechanisms underlying protracted PHN are not understood, and the lack of an animal model of herpes zoster (reactivation) makes this issue more challenging. A recent preclinical rodent model has developed that opens up the potential to allow the exploration of the underlying mechanisms and treatments for VZV-induced pain. Rats inoculated with live cell-associated human VZV into the hind paw reliably demonstrate thermal hyperalgesia and mechanical allodynia for extended periods and then spontaneously recover. Dorsal root ganglia express a limited VZV gene subset, including the IE62 regulatory protein, and upregulate expression of markers suggesting a neuropathic pain state. The model has been used to investigate treatment modalities and aspects of pain signaling and is under investigation by the authors to delineate VZV genetics involved in the induction of pain. This article compares human zoster-associated pain and PHN to the pain indicators in the rat and poses important questions that, if answered, could be the basis for new treatments.

  15. Herpes Simplex Virus Infection Mimicking Bullous Disease in an Immunocompromised Patient

    Directory of Open Access Journals (Sweden)

    Anne L.Y. Lecluse

    2010-06-01

    Full Text Available Immunodeficient patients are at risk of developing extended or atypical herpes simplex virus infections, which can be easily misdiagnosed. We present the case of a 79-year-old, treatment-induced (oral corticosteroid, immunocompromised female with an extensive atypical herpes simplex virus infection. This patient presented with multiple erosions and vesicles on the trunk with a subacute onset. The clinical differential diagnosis was herpes simplex infection, herpes zoster infection, pemphigus vulgaris or bullous pemphigoid. Due to the atypical clinical presentation and negative Tzanck test, suspicion of viral infection was low. High-dose steroid treatment was initiated. Subsequent histopathology, however, showed a herpes simplex virus infection. After discontinuing steroid treatment and initiating antiviral treatment, the patient recovered within a week. Emphasis must be placed on the importance of clinical awareness of extended and clinically atypical herpes simplex infections in immunocompromised patients. A negative Tzanck test does not rule out the possibility of a herpes infection.

  16. Dose related efficacy of gabapentin in acute herpetic neuralgia among geriatric patients

    Directory of Open Access Journals (Sweden)

    Sanjay Kumar Kanodia

    2012-01-01

    Full Text Available Background: Herpes zoster is an intractable painful condition, more severe in elderly patients. The pain during the first 30 days of onset is known as Acute Herpetic Neuralgia. Multiple treatments using non-steroidal anti-inflammatory drugs (NSAIDs, opioids, and tricyclic anti-depressants are available, but their side effects limit their use in geriatric patients. Gabapentin is also used in chronic neuropathic pain; however, its role in acute herpetic neuralgia is less explored. Aim : This study was aimed to determine dose related efficacy and safety of gabapentin in reducing pain of acute herpetic neuralgia in geriatric patients. Materials and Methods: In this placebo-controlled, four-week trial including 56 subjects, 42 patients received gabapentin in the dosage of 300 mg (n=15, 600 mg (n=14, and 900 mg(n=13 per day in divided doses and 14 patients received placebo within 72 hours of onset of herpes zoster. Results: Subjects receiving gabapentin had a statistically significant reduction (P0.05. Conclusion: The results of this study show that gabapentin is effective in acute herpetic neuralgia in different doses with 600 mg/day being the more appropriate dose in terms of safety and efficacy.

  17. Serum herpes simplex antibodies

    Science.gov (United States)

    ... 2. HSV-1 most often causes cold sores (oral herpes). HSV-2 causes genital herpes. How the Test ... whether a person has ever been infected with oral or genital herpes . It looks for antibodies to herpes simplex virus ...

  18. Refining criteria for diagnosis of cutaneous infections caused by herpes viruses through correlation of morphology with molecular pathology

    Directory of Open Access Journals (Sweden)

    Böer Almut

    2006-01-01

    Full Text Available BACKGROUND: Infections of the skin by herpes viruses do not always present themselves in typical fashion. Early diagnosis, however, is crucial for appropriate treatment. Polymerase chain reaction (PCR allows diagnosis and differential diagnosis of herpes virus infections, but the method is not yet available in large parts of the world, where diagnosis is made based on morphology alone. AIM: To refine criteria for the diagnosis of herpes virus infections of the skin by way of correlation of clinical and histopathologic findings with results of PCR studies. METHODS: We studied 75 clinically diagnosed patients of "zoster," "varicella," and "herpes simplex", to correlate clinical and histopathological findings with results of PCR studies on paraffin embedded biopsy specimens. RESULTS: Clinical suspicion of infection by herpes viruses was confirmed by histopathology in 37% of the cases and by PCR studies in 65% of the cases. Zoster was frequently misdiagnosed as infection with herpes simplex viruses (30%. When diagnostic signs of herpes virus infection were encountered histopathologically, PCR confirmed the diagnosis in 94%. By way of correlation with results of PCR studies, initial lesions of herpes virus infections could be identified to have a distinctive histopathological pattern. Herpetic folliculitis appeared to be a rather common finding in zoster, it occurring in 28% of the cases. CONCLUSION: We conclude that correlation of clinical and histopathological features with results of PCR studies on one and the same paraffin embedded specimen permits identification of characteristic morphologic patterns and helps to refine criteria for diagnosis both clinically and histopathologically.

  19. Varicella zoster vaccines and their implications for development of HSV vaccines

    Energy Technology Data Exchange (ETDEWEB)

    Gershon, Anne A., E-mail: aag1@columbia.edu [Department of Pediatrics, Columbia University College of Physicians and Surgeons, 620W. 168th Street, NY, NY 10032 (United States)

    2013-01-05

    Live attenuated vaccines to prevent varicella and zoster have been available in the US for the past 17 years, with a resultant dramatic decrease in varicella incidence and a predicted future decrease in the incidence of zoster. The pathogenesis and immune responses to varicella zoster virus (VZV) as well as the safety and effectiveness of VZV vaccines are reviewed. The lack of sterilizing immunity provided by VZV vaccines has not prevented them from being safe and effective. Virological and pathological information concerning parallels and differences between VZV and herpes simplex virus (HSV) are highlighted. Although VZV and HSV are distinct pathogens, they appear to have similarities in target organs and immunity that provide an expectation of a high likelihood for the success of vaccination against HSV, and predicted to be similar to that of VZV.

  20. Genital Herpes

    Science.gov (United States)

    ... fetal scalp electrode (tiny wire used to check fetal heart rate). Cesarean birth may be recommended if you have an active herpes sore or prodromal symptoms such as pain or burning when you go into labor. After ...

  1. Recurrent facial urticaria following herpes simplex labialis

    Directory of Open Access Journals (Sweden)

    Vijay Zawar

    2012-01-01

    Full Text Available We describe recurrent acute right-sided facial urticaria associated with herpes labialis infection in a middle-aged female patient. Antiviral medications and antihistamines not only successfully cleared the herpes infection and urticaria but also prevented further recurrences.

  2. Anti-NMDA Receptor antibody encephalitis with concomitant detection of Varicella zoster virus.

    Science.gov (United States)

    Solís, Natalia; Salazar, Lucrecia; Hasbun, Rodrigo

    2016-10-01

    The typical presentation of anti-NMDA (N-Methyl-d-Aspartate) receptor encephalitis involves young women with psychiatric, neurologic and autonomic symptoms; it is often associated with mature ovarian teratomas. NMDA receptor encephalitis has been described following Herpes simplex virus (HSV) encephalitis. This case describes a classic presentation of anti-NMDA receptor encephalitis with the concomitant presence of Varicella zoster virus in the cerebrospinal fluid.

  3. Epstein-Barr virus associated acute hepatitis with cross-reacting antibodies to other herpes viruses in immunocompetent patients: report of two cases.

    Science.gov (United States)

    Gupta, Ekta; Bhatia, Vikram; Choudhary, Aashish; Rastogi, Archana; Gupta, Naveen L

    2013-03-01

    Epstein-Barr virus (EBV) is the causative agent of infectious mononucleosis (IM) which is characterized by the triad of fever, sore throat, and lymphadenopathy. Self-limited, mild liver function test abnormalities are seen in IM. Acute hepatitis in primary EBV infection is uncommon. Serum transaminases are elevated but are less than fivefold the normal levels in most cases and rarely exceed 10 times the normal levels in primary EBV infections especially in elderly. Laboratory diagnosis of acute EBV infection is by serological assays confirming the presence of EBV viral capsid antigen (VCA) IgM antibodies. Due to antigenic cross-reactivity with Herpes viruses, serological assays lack specificity; hence specific molecular diagnostic methods are required for confirmation of the etiology. The present report describes two cases of acute hepatitis caused by infection with EBV which had indistinguishable clinical features and biochemical markers from acute hepatitis caused by hepatotropic viruses such as hepatitis viruses A-E. The diagnosis of infection by EBV was confirmed by detection of EBV DNA in blood of both the patients and EBV DNA in the liver tissue of one of the patients.

  4. Analysis of clinical characteristics and prognosis of 72 Herpes Zoster among HIV/AIDS patients in Xinjian g Yang Tongtong, Dong Yujie, Ainiwaer, Li Hong, Zhang Yu, Song Yuxia, Lu Xiaobo%艾滋病合并带状疱疹72例患者临床及预后分析

    Institute of Scientific and Technical Information of China (English)

    杨彤彤; 董玉洁; 艾尼瓦尔; 李弘; 张玉; 宋玉霞; 鲁晓擘

    2016-01-01

    Objective To investigate the clinical features, treatment effect and prognosis of Herpes Zoster( HZ) among patients with acquired immunodeficiency syndrome ( AIDS) .Methods Clinical data of 72 AIDS-HZ patients in our hospital were retrospectively reviewed, then the data including clinical characteristics, laboratory examination, treatment and the prognosis of patients were statistically analyzed. Results Our study showed that the majority of these patients were male ( 65.28%) and Uyghur (79.17%), with a mean age of 37.22 ±8.26 years.39(54.17%) patients have a history of intravenous drug using (IDUs).The rash was common seen in the trunk (68.06%) and limbs (26.39%), two or more than two were seen in 12 patients (16.67%).21(29.17%) were combined by skin infections and 67 patients (93.06%) complained with pain.Forty seven(65.28%) patients had a lower CD4 +T lymphocyte counts (<350 cells/μl).The cure rate was 75%(54/72) and the effective rate was 100%after standard treatment ( including antiretroviral therapy, drugs and analgesia therapy) .Conclusions HIV/AIDS-HZ is common in male Uygur patients in Xinjiang.More than half of the cases are IDUs and have a lower CD4 count ( <350 cells/μl ) .Herpes zoster may occurred as a manifestation of immune reconstitution after HAART.However, most of patients with HIV/AIDS-HZ case had a good prognosis after standard treatment.%目的:分析艾滋病合并带状疱疹患者的临床特征、治疗效果及预后。方法采用回顾性研究的方法,对新疆维吾尔自治区第六人民医院收治的72例艾滋病合并带状疱疹患者的临床表现、实验室检查、治疗及转归进行总结分析。结果患者以男性(65.28%)、维吾尔族(79.17%)为主,平均年龄37.22±8.26岁,有静脉吸毒史者39例(54.17%)。皮疹发生部位以躯干(68.06%)和四肢(26.39%)较常见,16.67%发生在2个及以上部位。21例(29.17%)合并疱疹部位皮肤感染,67

  5. Study on the effect of implementing General practice clinical pathway on patients with Herpes zoster or Facial neuritis%应用全科临床路径治疗带状疱疹、面神经炎的效果分析

    Institute of Scientific and Technical Information of China (English)

    李树然; 吴欣欣

    2015-01-01

    Objective To analyze the effect of implementing General practice clinical pathway on family sickbed patients. Methods 156 cases of home sickbed patients with herpes zoster or facial neuritis were involved in this study.Their medical records and data of 'Home sickbed quality control scale' were collected and analyzed,in which there are methods of General practice clinical pathway,decoction of the Chinese Medicine,ingredients and treatment procedures of the topically used TCMs,and acupuncture treatment procedures were documented.The family sickbed days,prognosis,rate of informed and rate of satisfaction were analyzed before and after General practice clinical pathway treatment. Results In the observation group, the family sickbed days(10.65±1.83)d and rate of referral 10.26% were significantly lower(P < 0.01) than those in the control group(13.65±2.42)d,48.72% respectively. The rate of cure 89.74% ,the rate of informed patient 97.44% and the rate of satisfaction93.59% were significantly higher(P < 0.01) than those in the control group 51.28%、67.95%、51.28%. Conclusion It is worth to implement general practice clinical pathway for patients in home sickbeds with herpes zoster or facial neuritis,It could regulate the behavior of bed setting,improve patient's rate of cur,rate of informed and the rate of satisfaction,prevent medical risk and fully embody the idea of "people-oriented".%目的:分析家庭病床患者实施全科临床路径后的成效。方法收集156例家庭病床中带状疱疹、面神经炎(面瘫)患者的病案资料,统计分析《家庭病床质量控制量表》中带状疱疹、面神经炎的全科临床路径、具体口服药物、外用药物种类及疗程、中医治疗疗程等资料,通过回顾性研究及非同期历史对照,以实施全科临床路径前为对照组,实施全科临床路径后为观察组,比较两组患者的建立家庭病床天数、预后、知情率和满意度等。结果观察组的建

  6. Prevalence and clinical consequences of herpes simplex virus type 1 DNA in human cornea tissues

    NARCIS (Netherlands)

    L. Remeijer (Lies); R. Duan (Rui); J.M. van Dun (Jessica); M.A.W. Bettink; A.D.M.E. Osterhaus (Ab); G.M.G.M. Verjans (George)

    2009-01-01

    textabstractBackground. We determined the prevalence and clinical consequences of herpes simplex virus (HSV) type 1 (HSV-1), HSV type 2 (HSV-2), and varicella-zoster virus (VZV) in cornea tissues obtained after penetrating keratoplasty (PKP) was performed. Methods. The excised corneas of 83 patients

  7. Genital Herpes

    Science.gov (United States)

    ... less often and the symptoms become milder. The virus stays in your body for life. There are tests that can diagnose genital herpes. There is no cure. However, medicines can help lessen symptoms, decrease ... risk of passing the virus to others. Correct usage of latex condoms can ...

  8. Genital Herpes

    Science.gov (United States)

    ... best way to prevent genital herpes is abstinence. Teens who do have sex must properly use a latex condom every time ... Date reviewed: February 2016 previous 1 • ... Boyfriend Has an STD Before We Have Sex? Telling Your Partner You Have an STD Contact ...

  9. THE DIFFERENCE OF THERMAL SENSATION THRESHOLD IN PATIENTS WITH HERPES ZOSTER AND POST HERPETIC NEURALGIA%带状疱疹与带状疱疹后神经痛患者温度觉阈值变化及其意义

    Institute of Scientific and Technical Information of China (English)

    史学莲; 刘小立; 宛春甫; 吴振华; 张静; 杨书芳; 杨娟丽; 张健; 陈璐

    2011-01-01

    Objective: To analyze the thermal thresholds in patients with herpes zoster (HZ) and post herpetic neuralgia (PHN), and to speculate the mechanism of HZ and PHN. Methods: The TSA-Ⅱ thermal sensory analyzer was used to test the different sensory modalities in patients with HZ and PHN as well as in the control group subjects. Results: The threshold of cold sensation, warm sensation and heat pain sensation in patients with PHN was significantly elevated when compared with corresponding threshold in patients with HZ, especially in cold sensation. No significant correlation between cold sensation threshold and warm sensation threshold was found, while a negative correlation between cold sensation and warm sensation in patients with PHN was observed. Conclusion: The degree of injured Aδ, C primary afferent fibers is aggravated during the process of HZ to PHN, especially the injured Aδ fibers which conducts cold sensation. The tolerances of cold sensation, warm sensation and heat pain sensation in patients with PHN were higher than that in patients with HZ, while the ability to discriminate between thermal sensation and pain sensation was lower than that in patients with HZ.%目的:分析躯干部位带状疱疹、带状疱疹后神经痛患者皮肤温度觉阈值的变化与差异,推测其感觉功能改变及疼痛的病理机制.方法:应用NA-Ⅱ温度觉定量分析仪测定躯干部位带状疱疹、带状疱疹后神经痛患者及对照组相应皮肤的温度觉阈值.结果:带状疱疹后神经痛患者较带状疱疹患者皮肤的冷觉、热觉、热痛觉阈值均升高,其中冷觉阈值升高最为明显.带状疱疹患者冷觉与热觉阈值之间相关性无统计学意义,而带状疱疹后神经痛患者冷觉与热觉阈值之间呈负相关.结论:病变发展过程中,Aδ,C类神经纤维损伤程度有所加重,并以传导冷觉的Aδ神经纤维受损更为严重,表现为带状疱疹后神经痛患者对冷觉、热觉和热痛觉耐

  10. Clinical Observation of Spinal Nerve Dorsal Root Impulse Radio Frequency Combined with Epidural Nerve Block in the Treatment of Post Herpes Zoster Neuralgia%脊神经背根脉冲射频联合硬膜外神经阻滞治疗带状疱疹后神经痛的临床观察

    Institute of Scientific and Technical Information of China (English)

    邓茹; 刘庆

    2016-01-01

    目的:采用新型微创脊神经背根脉冲射频联合硬膜外神经阻滞治疗带状疱疹后神经痛,探讨两种方法结合治疗带状疱疹后神经痛的临床疗效,观测它和生活质量之间关系,从而为PHN治疗提供借。方法以泸州医学院附属中医院疼痛科2011年12月~2012年12月符合标准的带状疱疹后神经痛患者60例作为研究对象。并随机将其划分成硬膜外神经阻滞复合加巴喷丁和硬膜外神经阻滞复合加巴喷丁+脊神经背根脉冲射频组。进行五次A、B两组患者的视觉模拟评分,自评抑郁量表以及焦虑自评量表评分。结果①VAS评分、抑郁评分院与T0比较,A组和B组T1~T4时VAS评分、抑郁评分显著降低。和A组相比,B组T1~T4各时点VAS评分、抑郁评分显著降低。②焦虑评分院与T0比较,A组和B组T1~T4时焦虑评分显著降低;与A组比较,B组T2~T4各时点焦虑评分显著降低。结论①两种方案治疗PHN均有效,但联合脊神经背根脉冲射频疗效更好。②PHN患者的抑郁和焦虑评分随着疼痛的缓解降低。%Objective A new minimally invasive dorsal root pulsed radiofrequency treatment combined with epidural nerve block postherpetic neuralgia, explore the relationship between clinical efficacy neuralgia, observing that the two methods and quality of life after combined treatment of herpes zoster , by providing for the treatment of PHN. Methods Affiliated Hospital of Luzhou Pain in December 2011 - after the period December 2012-compliant herpetic neuralgia 60 patients for the study. And randomly divided into epidural nerve block combined gabapentin (A group, n=30) and epidural nerve block combined gabapentin+dorsal root pulsed radiofrequency (group B, n=30). Five times A, B groups were visual analog scale, self-rating depression scale and self-rating anxiety scale score. Results ①VAS score, depression score: Compared with T0, A group A and group B T1-T4 when the VAS

  11. Do herpes e suas implicações audiológicas: uma revisao de literatura Herpes and its hearing implications: a literature review

    Directory of Open Access Journals (Sweden)

    Larissa Cristina Schuster

    2009-12-01

    Full Text Available TEMA: herpes e audiologia. OBJETIVO: realizar revisão teórica principalmente sobre os vírus herpes simples tipo 1, herpes simples tipo 2 e varicela-zoster, bem como sobre seus efeitos na audição humana. Esses se constituem nos tipos de vírus herpéticos humanos de maior relevância para a área da Audiologia dentro da ciência da Fonoaudiologia e, no entanto, são pouco conhecidos e estudados, especialmente no Brasil. MÉTODOS: realizou-se pesquisa em bases de dados eletrônicas nacionais e internacionais, incluindo SciELO, MEDLINE e LILACS, a partir da seguinte combinação de descritores: herpes simplex/zoster X hearing loss ou deafness. Foram selecionados estudos publicados desde a década de 90 até os dias atuais, relevando-se aqueles que contivessem maior valor informativo, contribuindo para os objetivos do presente trabalho. CONCLUSÃO: os vírus herpéticos estudados apresentam estreita relação com distúrbios auditivos, independentemente da idade em que o sujeito é acometido.BACKGROUND: herpes and audiology. PURPOSE: to promote a theoretical approach mainly on herpes simplex virus type 1, herpes simplex virus type 2 and varicella zoster virus, and their effects on human hearing. Although representing the most relevant human herpetic viruses for the area of Audiology within the Speech and Language Pathology Science, these viruses are little studied and known, especially in Brazil. METHODS: a research was carried out in national and international electronic databases, including SciELO, MEDLINE and LILACS, and using the following keyword combinations: herpes simplex/zoster X hearing loss or deafness. Studies published from the 90's until today were selected, revealing those that would contain the highest informative value, which would thus contribute for the objectives of this work. CONCLUSION: the studied herpetic viruses show strict relation with hearing disorders, regardless of the age in which the patient is affected.

  12. Vírus varicela zoster em paralisia de Bell: estudo prospectivo Varicella zoster virus in Bell's palsy: a prospective study

    Directory of Open Access Journals (Sweden)

    Mônica Alcantara de Oliveira Santos

    2010-06-01

    Full Text Available Embora a paralisia de Bell seja o tipo mais frequente de paralisia facial periférica,sua causa ainda é objeto de inúmeros questionamentos. A reativação do vírus varicela zoster tem sido considerada uma das principais causas da paralisia de Bell, porém, os poucos trabalhos que estudam a prevalência do VVZ como agente etiológico da PB são japoneses, o que determina características geográficas e populacionais bastante díspares de nossa população. OBJETIVOS: Verificar a frequência do vírus varicela zoster em saliva de indivíduos com PB, pela técnica de PCR. MATERIAL E MÉTODO: Estudo prospectivo com 171 pacientes com PFP, sendo 120 pacientes portadores de paralisia de Bell, com até uma semana de evolução, sem uso prévio de drogas antivirais. O grupo controle foi composto de 20 adultos sadios. Nestes indivíduos foram coletadas três amostras de saliva em semanas consecutivas, para pesquisa de DNA viral pela técnica de PCR. RESULTADOS: O vírus varicela zoster foi encontrado em amostras de saliva de dois pacientes com paralisia de Bell (1,7%. Nenhum vírus foi identificado no grupo controle. CONCLUSÃO: Foi verificada frequência de 1,7% para vírus varicela zoster em amostras de saliva de pacientes com paralisia de Bell, pela técnica de PCR.Although Bell's palsy is the major cause of acute peripheral facial palsy, its pathogenesis remains unknown. Reactivation of the varicella zoster virus has been implicated as one of the main causes of Bell's palsy, however, studies which investigate the varicella zoster virus reactivation in Bell's palsy patients are mostly Japanese and, therefore, personal and geographic characteristics are quite different from our population. AIMS: To determine varicella zoster virus frequency in saliva samples from patients with Bell's palsy, using PCR. MATERIAL AND METHOD: One hundred seventy one patients with acute peripheral facial palsy were prospectively enrolled in this study. One hundred twenty

  13. Dendritic cells as Achilles' heel and Trojan horse during varicella zoster virus infection

    Directory of Open Access Journals (Sweden)

    Günther eSchönrich

    2015-05-01

    Full Text Available Varicella zoster virus (VZV, a human alphaherpesvirus, causes varicella and subsequently estab-lishes latency within sensory nerve ganglia. Later in life VZV can reactivate to cause herpes zoster. A reduced frequency of VZV-specific T cells is strongly associated with herpes zoster illustrating that these immune cells are central to control latency. Dendritic cells (DCs are required for the generation of VZV-specific T cells. However, DCs can also be infected in vitro and in vivo allowing VZV to evade the antiviral immune response. Thus, DCs represent the immune systems’ Achilles heel. Uniquely among the human herpesviruses, VZV infects both DCs and T cells, and exploits both as Trojan horses. During primary infection VZV-infected DCs traffic to the draining lymph nodes and tonsils, where the virus is transferred to T cells. VZV-infected T cells subsequently spread infection throughout the body to give the typical varicella skin rash. The delicate interplay between VZV and DCs and its consequences for viral immune evasion and viral dissemination will be discussed in this article.

  14. Varicella-Zoster-Mediated Radiculitis Reactivation following Cervical Spine Surgery: Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Doniel Drazin

    2013-01-01

    Full Text Available Varicella-zoster virus and herpes simplex virus types 1 and 2 are neurotropic viruses that can be reactivated after a surgical or stressful intervention. Although such cases are uncommon, consequences can be debilitating, and variable treatment responses merit consideration. We describe a 41-year-old male with a history of varicella-mediated skin eruptions, who presented with continuing right arm pain, burning, and numbness in a C6 dermatomal distribution following a C5-6 anterior cervical discectomy and fusion and epidural steroid injections. The operative course was uncomplicated and he was discharged home on postoperative day 1. Approximately ten days after surgery, the patient presented to the emergency department complaining of severe pain in his right upper extremity and a vesicular rash from his elbow to his second digit. He was started on Acyclovir and discharged home. On outpatient follow-up, his rash had resolved though his pain continued. The patient was started on a neuromodulating agent for chronic pain. This case adds to the limited literature regarding this rare complication, brings attention to the symptoms for proper diagnosis and treatment, and emphasizes the importance of prompt antiviral therapy. We suggest adding a neuromodulating agent to prevent long-term sequelae and resolve acute symptoms.

  15. Meet the Herps.

    Science.gov (United States)

    Naturescope, 1987

    1987-01-01

    Describes some of the characteristics of "herps" (amphibians and reptiles). Contains teaching activities dealing with ancient herps, learning stations that encourage sensory experiences with herps, and games, puzzles, and a dramatic play about herps. Includes reproducible handouts designed to be used with the activities, as well as a quiz. (TW)

  16. Burning mouth syndrome associated with varicella zoster virus.

    Science.gov (United States)

    Nagel, Maria A; Gilden, Don

    2016-07-05

    We present two cases of burning mouth syndrome (BMS)-of 8-month duration in a 61-year-old woman and of 2-year duration in a 63-year-old woman-both associated with increased levels of antivaricella zoster virus (VZV) IgM antibodies in serum and with pain that improved with antiviral treatment. Combined with our previous finding of BMS due to herpes simplex virus type 1 (HSV-1) infection, we recommend evaluation of patients with BMS not only for VZV or HSV-1 DNA in the saliva, but also for serum anti-VZV and anti-HSV-1 IgM antibodies. Both infections are treatable with oral antiviral agents.

  17. Atypical Presentation of Disseminated Zoster in a Patient with Rheumatoid Arthritis

    Directory of Open Access Journals (Sweden)

    Nirav Patel

    2015-01-01

    Full Text Available Patients with rheumatoid arthritis (RA have 2-fold increased risk of herpes zoster. In literature, limited information exists about disseminated cutaneous zoster in RA patients. An 83-year-old African-American female with RA presented with generalized and widespread vesicular rash covering her entire body. Comorbidities include hypertension, type II diabetes, and dyslipidemia. Patient was on methotrexate 12.5 mg and was not receiving any corticosteroids, anti-TNF therapy, or other biological agents. The patient was afebrile (98 F with no SIRS criteria. Multiple vesicular lesions were present covering patient’s entire body including face. Lesions were in different stages, some umbilicated with diameter of 2–7 cm. Many lesions have a rim of erythema with no discharge. On admission, patient was also pancytopenic with leukocyte count of 1.70 k/mm3. Biopsies of lesions were performed, which were positive for Varicella antigen. Subsequently, patient was started on Acyclovir. The patient’s clinical status improved and rash resolved. Our patient presented with “atypical” clinical picture of disseminated cutaneous zoster with no obvious dermatome involvement. Disseminated zoster is a potentially serious infection that can have an atypical presentation in patients with immunocompromised status. High index of suspicion is needed to make the diagnosis promptly and to initiate therapy to decrease mortality and morbidity.

  18. Herpes Virus Entry Mediator Signaling in the Brain Is Imperative in Acute Inflammation-Induced Anorexia and Body Weight Loss

    Directory of Open Access Journals (Sweden)

    Kwang Kon Kim

    2013-09-01

    Full Text Available BackgroundReduced appetite and body weight loss are typical symptoms of inflammatory diseases. A number of inflammatory stimuli are responsible for the imbalance in energy homeostasis, leading to metabolic disorders. The herpes virus entry mediator (HVEM protein plays an important role in the development of various inflammatory diseases, such as intestinal inflammation and diet-induced obesity. However, the role of HVEM in the brain is largely unknown. This study aims to investigate whether HVEM signaling in the brain is involved in inflammation-induced anorexia and body weight loss.MethodsFood intake and body weight were measured at 24 hours after intraperitoneal injection of lipopolysaccharide (LPS or intracerebroventricular injection of recombinant mouse LIGHT (also called tumor necrosis factor receptor superfamily 14, TNFSF14, an HVEM ligand, into 8- to 10-week-old male C57BL/6 mice and mice lacking HVEM expression (HVEM-/-. We also assessed LPS-induced change in hypothalamic expression of HVEM using immunohistochemistry.ResultsAdministration of LPS significantly reduced food intake and body weight, and moreover, increased expression of HVEM in the hypothalamic arcuate nucleus. However, LPS induced only minor decreases in food intake and body weight in HVEM-/- mice. Administration of LIGHT into the brain was very effective at decreasing food intake and body weight in wild-type mice, but was less effective in HVEM-/- mice.ConclusionActivation of brain HVEM signaling is responsible for inflammation-induced anorexia and body weight loss.

  19. Varicella Zoster Virus and Relapsing Remitting Multiple Sclerosis

    Directory of Open Access Journals (Sweden)

    Julio Sotelo

    2011-01-01

    Full Text Available Multiple sclerosis (MS is an immune-mediated disorder; however, little is known about the triggering factors of the abnormal immune response. Different viruses from the herpes family have been mentioned as potential participants. Here, we review the evidences that support the association of varicella zoster virus (VZV with MS. Epidemiological studies from geographical areas, where incidence of MS has increased in recent decades, pointed out a high frequency of varicella and zoster in the clinical antecedents of MS patients, and also laboratory investigations have found large quantities of DNA from VZV in leucocytes and cerebrospinal fluid of MS patients restricted to the ephemeral period of MS relapse, followed by disappearance of the virus during remission. The above observations and the peculiar features of VZV, mainly characterized by its neurotropism and long periods of latency followed by viral reactivation, support the idea on the participation of VZV in the etiology of MS. However, as with reports from studies with other viruses, particularly Epstein Barr virus, conflicting results on confirmatory studies about the presence of viral gene products in brain tissue indicate the need for further research on the potential participation of VZV in the etiology of MS.

  20. A Case of 72 Diabetic Woman with Zoster Paresis

    Directory of Open Access Journals (Sweden)

    E. Sajadi

    2009-10-01

    Full Text Available Introduction: VZV is an exclusively human pathogen. The primary infection typically occurs during childhood and causes varicella. As with other members of the herpes viruses’ family, VZV is noninfectious in its latent form but can reactivate at a later time to form intact virions in the involved sensory neurons. These virions then migrate to the skin through axons, spread from cell to cell, and penetrate the epidermis.Case Report: In this case a 72 years old woman with history of diabetes mellitus and hypertension is reported hospitalized because of urinary retention, weakness and parestesia in the right leg, complicated with vesiculoulcerative lesions in sacral area with distribution to the right buttock and vagina. L.P was done to confirm inflammatory radicopathy that showed aseptic meningitis and therapy started with acyclovir and prednisolone. Patient got well and discharged from the hospital.Conclusion: Motor weakness in noncranial nerve is one of the zoster complications known as zoster paresis. Weakness begins suddenly 2-3 weeks after rash and progresses to extremities. In this case 3 weeks after rash, nerve complications were observed. We recommend to do paresthesia examination of skin for eruption in all patients presented with paresis.

  1. [Infections in the child with acute leukemia].

    Science.gov (United States)

    Carrillo, J M; Jiménez, E; Jiménez, R

    1981-01-01

    One hundred and twenty-five febrile episodes in 82 children with acute leukemia were studied; 46% of the patients were from urban and 54% from rural areas. The origin of the fever was identified in 91% of the episodes, prevailing pneumonia, septicemia, chickenpox and herpes zoster. The etiological agent was identified in 46% of the cases. A viral predominance was evident, and among them varicela-zoster, following in importance gram-negative bacteria. Histoplasma capsulatum and Pneumocystis carinii were isolated in two occassions each. Sepsis was found more frequently in children with active leukemia than in those in remission (p less than 0.001). Forty-four febrile episodes occurred in patients with less than 1,000 neutrophils/ul. The daily-risk rate of infection was higher in children fom rural than in those from urban areas (p less than 0.001). After clinical and laboratory studies, methicillin and gentamicin were used, in addition to carbenicillin or trimethoprim-sulfamethoxazole is selected cases. This treatment was effective in 86% of the cases. Twelve (15%) children died, 6 of whom were in remission at that moment.

  2. Elaboration of a clinical and paraclinical score to estimate the probability of herpes simplex virus encephalitis in patients with febrile, acute neurologic impairment.

    Science.gov (United States)

    Gennai, S; Rallo, A; Keil, D; Seigneurin, A; Germi, R; Epaulard, O

    2016-06-01

    Herpes simplex virus (HSV) encephalitis is associated with a high risk of mortality and sequelae, and early diagnosis and treatment in the emergency department are necessary. However, most patients present with non-specific febrile, acute neurologic impairment; this may lead clinicians to overlook the diagnosis of HSV encephalitis. We aimed to identify which data collected in the first hours in a medical setting were associated with the diagnosis of HSV encephalitis. We conducted a multicenter retrospective case-control study in four French public hospitals from 2007 to 2013. The cases were the adult patients who received a confirmed diagnosis of HSV encephalitis. The controls were all the patients who attended the emergency department of Grenoble hospital with a febrile acute neurologic impairment, without HSV detection by polymerase chain reaction (PCR) in the cerebrospinal fluid (CSF), in 2012 and 2013. A multivariable logistic model was elaborated to estimate factors significantly associated with HSV encephalitis. Finally, an HSV probability score was derived from the logistic model. We identified 36 cases and 103 controls. Factors independently associated with HSV encephalitis were the absence of past neurological history (odds ratio [OR] 6.25 [95 % confidence interval (CI): 2.22-16.7]), the occurrence of seizure (OR 8.09 [95 % CI: 2.73-23.94]), a systolic blood pressure ≥140 mmHg (OR 5.11 [95 % CI: 1.77-14.77]), and a C-reactive protein probability score was calculated summing the value attributed to each independent factor. HSV encephalitis diagnosis may benefit from the use of this score based upon some easily accessible data. However, diagnostic evocation and probabilistic treatment must remain the rule.

  3. Varicella Zoster Virus in the Nervous System [version 1; referees: 3 approved

    Directory of Open Access Journals (Sweden)

    Don Gilden

    2015-11-01

    Full Text Available Varicella zoster virus (VZV is a ubiquitous, exclusively human alphaherpesvirus. Primary infection usually results in varicella (chickenpox, after which VZV becomes latent in ganglionic neurons along the entire neuraxis. As VZV-specific cell-mediated immunity declines in elderly and immunocompromised individuals, VZV reactivates and causes herpes zoster (shingles, frequently complicated by postherpetic neuralgia. VZV reactivation also produces multiple serious neurological and ocular diseases, such as cranial nerve palsies, meningoencephalitis, myelopathy, and VZV vasculopathy, including giant cell arteritis, with or without associated rash. Herein, we review the clinical, laboratory, imaging, and pathological features of neurological complications of VZV reactivation as well as diagnostic tests to verify VZV infection of the nervous system. Updates on the physical state of VZV DNA and viral gene expression in latently infected ganglia, neuronal, and primate models to study varicella pathogenesis and immunity are presented along with innovations in the immunization of elderly individuals to prevent VZV reactivation.

  4. Antivirals reduce the formation of key Alzheimer's disease molecules in cell cultures acutely infected with herpes simplex virus type 1.

    Directory of Open Access Journals (Sweden)

    Matthew A Wozniak

    Full Text Available Alzheimer's disease (AD afflicts around 20 million people worldwide and so there is an urgent need for effective treatment. Our research showing that herpes simplex virus type 1 (HSV1 is a risk factor for AD for the brains of people who possess a specific genetic factor and that the virus causes accumulation of key AD proteins (β-amyloid (Aβ and abnormally phosphorylated tau (P-tau, suggests that anti-HSV1 antiviral agents might slow AD progression. However, currently available antiviral agents target HSV1 DNA replication and so might be successful in AD only if Aβ and P-tau accumulation depend on viral DNA replication. Therefore, we investigated firstly the stage(s of the virus replication cycle required for Aβ and P-tau accumulation, and secondly whether antiviral agents prevent these changes using recombinant strains of HSV1 that progress only partly through the replication cycle and antiviral agents that inhibit HSV1 DNA replication. By quantitative immunocytochemistry we demonstrated that entry, fusion and uncoating of HSV1, are insufficient to induce Aβ and P-tau production. We showed also that none of the "immediate early" viral proteins is directly responsible, and that Aβ and P-tau are produced at a subsequent stage of the HSV1 replication cycle. Importantly, the anti-HSV1 antiviral agents acyclovir, penciclovir and foscarnet reduced Aβ and P-tau accumulation, as well as HSV1, with foscarnet being less effective in each case. P-tau accumulation was found to depend on HSV1 DNA replication, whereas Aβ accumulation was not. The antiviral-induced decrease in Aβ is attributable to the reduced number of new viruses, and hence the reduction in viral spread. Since antiviral agents reduce greatly Aβ and P-tau accumulation in HSV1-infected cells, they would be suitable for treating AD with great advantage unlike current AD therapies, only the virus, not the host cell, would be targeted.

  5. Bilateral acute retinal necrosis after herpetic meningitis

    Directory of Open Access Journals (Sweden)

    Katsura T

    2012-04-01

    Full Text Available Keisho Hirota1,2, Masayuki Akimoto1,3, Toshiaki Katsura21Department of Ophthalmology, Kyoto Medical Center, National Hospital Organization, 2Internal Medicine, Kyoto Medical Center, 3Clinical Research Center, Kyoto Medical Center, Kyoto, JapanPurpose: The report of a case of bilateral acute retinal necrosis after herpetic meningitis.Case report: A 47-year-old man was admitted with the chief complaint of persistent high fever and transient loss of consciousness. Although his general condition improved after intravenous acyclovir administration, the patient presented with visual loss in both eyes 4 days after admission. Visual acuity in his right eye was 20/200 and his left eye had light perception alone. Both eyes showed panretinal arteritis diagnosed as acute retinal necrosis. Panretinal photocoagulation was performed for both eyes. Progression of retinal detachment was prevented in both eyes; however, visual acuity of the left eye was totally lost because of neovascular glaucoma. Visual acuity of the right eye recovered to 20/20.Conclusion: Although cases of bilateral acute retinal necrosis have been reported after herpetic encephalitis, this condition is rare after herpetic meningitis. Prophylactic acyclovir therapy and early panretinal photocoagulation may prevent retinal detachment and improve the prognosis. Neurologists and ophthalmologists should be aware that not only herpetic encephalitis but also herpetic meningitis can lead to acute retinal necrosis within a very short interval.Keywords: acute retinal necrosis, herpetic meningitis, herpes simplex, varicella zoster virus

  6. Acute HIV illness following blood transfusion in three African children.

    Science.gov (United States)

    Colebunders, R; Greenberg, A E; Francis, H; Kabote, N; Izaley, L; Nguyen-Dinh, P; Quinn, T C; Van der Groen, G; Curran, J W; Piot, P

    1988-04-01

    Three children are described in whom pre-transfusion samples were HIV-seronegative and post-transfusional samples, obtained within 1 week after transfusion, were HIV-seropositive. Two of them developed a transient fever within 1 week of receiving the blood transfusion, and a transient generalized skin eruption which lasted for about 2 weeks. All three developed persistent generalized lymphadenopathy. One child developed a lumbar herpes zoster 7 months after transfusion. IgM Western blots demonstrated the presence of antibodies to protein bands p17, p24 and p55 in all three children. These three case reports suggest that children who receive a seropositive blood transfusion are at high risk for developing acute manifestations of HIV infection.

  7. De Novo Herpes Simplex Virus VP16 Expression Gates a Dynamic Programmatic Transition and Sets the Latent/Lytic Balance during Acute Infection in Trigeminal Ganglia.

    Science.gov (United States)

    Sawtell, Nancy M; Thompson, Richard L

    2016-09-01

    The life long relationship between herpes simplex virus and its host hinges on the ability of the virus to aggressively replicate in epithelial cells at the site of infection and transport into the nervous system through axons innervating the infection site. Interaction between the virus and the sensory neuron represents a pivot point where largely unknown mechanisms lead to a latent or a lytic infection in the neuron. Regulation at this pivot point is critical for balancing two objectives, efficient widespread seeding of the nervous system and host survival. By combining genetic and in vivo in approaches, our studies reveal that the balance between latent and lytic programs is a process occurring early in the trigeminal ganglion. Unexpectedly, activation of the latent program precedes entry into the lytic program by 12 -14hrs. Importantly, at the individual neuronal level, the lytic program begins as a transition out of this acute stage latent program and this escape from the default latent program is regulated by de novo VP16 expression. Our findings support a model in which regulated de novo VP16 expression in the neuron mediates entry into the lytic cycle during the earliest stages of virus infection in vivo. These findings support the hypothesis that the loose association of VP16 with the viral tegument combined with sensory axon length and transport mechanisms serve to limit arrival of virion associated VP16 into neuronal nuclei favoring latency. Further, our findings point to specialized features of the VP16 promoter that control the de novo expression of VP16 in neurons and this regulation is a key component in setting the balance between lytic and latent infections in the nervous system.

  8. High-resolution CT findings of varicella-zoster pneumonia

    Energy Technology Data Exchange (ETDEWEB)

    Choo, Hye Jeung; Kim, Kun Il [Busan National Univ. Hospital, Busan (Korea, Republic of); Lee, Ki Nam [College of Medicine, Donga Univ., Busan (Korea, Republic of)

    2003-12-01

    To describe the high-resolution CT findings of varicella-zoster pneumonia. Seven adult patients with clinically and serologically diagnosed varicella-zoster pneumonia underwent HRCT scanning. One had undergone a kidney transplant, and the others were immunocompetent. The HRCT findings were retrospectively analyzed by two radiologists in terms of the presence of a nodule, pneumonia consolidation, ground-glass attenuation and pleural effusion, and with regard to the number, size and distribution of nodules. HRCT findings of varicella pneumonia included nodule (n=7), consolidation (n=3), diffuse ground-glass attenuation (n=1) and pleural effusion (n=1). Nodules were mostly 2-10 mm in size, and multiple (n=6), and zonal predominancy was not apparent. One case in which HRCT demonstrated diffuse ground-glass opacity and slight bilateral pleural effusion involved a patient in whom complications of acute respiratory distress syndrome occured. When HRCT demonstrates the presence of nodules 2-10 mm in size multiple nodules, or nodule surrounded by ground-glass attenuation, or the coalescence of nodules and consolidation is observed in adults with chickenpox, the varicella-zoster pneumonia should be included in the differential diagnosis.

  9. Incidence of Alpha-Herpes virus induced ocular disease in Suriname.

    Science.gov (United States)

    Adhin, Malti R; Grunberg, Meritha G; Labadie-Bracho, Mergiory; Pawiroredjo, Jerrel

    2012-12-01

    Herpes simplex virus (HSV) infection of the corneal stroma is the most prominent cause of scar formation impairing visual acuity and HSV keratitis is the leading cause of corneal opacity throughout the world. Suriname lacked test systems for microbial causes of ocular disease, therefore a polymerase chain reaction-based Herpes virus assay was introduced, enabling prompt recognition, and timely treatment, preventing progressive eye damage. The incidence and epidemiology of Herpes simplex virus type 1 (HSV-1), type 2 (HSV-2), and varicella zoster virus (VZV) in ocular disease in Suriname was assessed. In a cross-sectional prospective study, ocular swabs were collected from 91 patients with a presumptive α-Herpes virus ocular infection attending the Academic Hospital between November 2008 and August 2010 and were tested by a PCR-based α-Herpes virus assay. Alpha-Herpes virus ophthalmic infections were caused predominantly by HSV-1 with a prevalence of 31%. The prevalences of VZV, HSV-2, and a mixed HSV-1/HSV-2 infection were 4%, 3%, and 2%, respectively. The first reported annual incidence of herpetic induced ocular disease in Suriname was estimated at 11.4 per 100,000 person-years (95% CI, 4.8-18.1). No clear age, ethnic or gender dependent difference in incidence was observed. The information obtained on α-Herpes virus positive ocular infections and the distribution of subtypes provided the first insight in the South American situation of α-Herpes virus induced ocular disease.

  10. Pregnancy Complications: Genital Herpes

    Science.gov (United States)

    ... can get an STD from vaginal, anal or oral sex. Most people get genital herpes from having sex with an infected person, but ... Genital herpes is caused by two viruses called herpes simplex viruses (also called ... and fever blisters on the mouth and lips. The virus spreads from the mouth ...

  11. Clinic Characteristics of Varicella Zoster Myocarditis

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective To analyze the clinic characteristics of varicella zoster myocarditis and to determine the diagnostic value of serum cardiac troponin I (cTnI ) on the disease. Methods Information of 58 hospitalized patients with varicella zoster was collected, and the incidence of varicella zoster myocarditis and clinic characteristics (ECG, cTnI, age and sex distribution, etc. ) were analyzed respectively. Results It was found that 36.2% of the patients developed myocarditis. The old and female persons were much more susceptible to varicella zoster myocarditis. All patients had responsive ECG manifestations, and the abnormal ST-T changes were more common than other ECG abnormalities. CTnI remained higher than normal and had significant diagnostic value. Most of the patients had good prognosis, only a few patients lasted a long time and even progressed into cardiomyopathy. Nearly all the patients came to see dermatologists when they felt ill initially. That would lead to more misdiagnosis. Conclusion Infection of varicella zoster can complicate myocarditis, we must pay more attention to the patients who suffer from varicella zoster especially in the aged and female; cTnI is an important and effective index for diagnosis of varicella zoster myocarditis.

  12. Herpes simplex ulcerative esophagitis in healthy children

    Directory of Open Access Journals (Sweden)

    Abdulrahman A Al-Hussaini

    2011-01-01

    Full Text Available Herpes simplex virus is a common cause of ulcerative esophagitis in the immunocompromised or debilitated host. Despite a high prevalence of primary and recurrent Herpes simplex virus infection in the general population, Herpes simplex virus esophagitis (HSVE appears to be rare in the immunocompetent host. We report three cases of endoscopically-diagnosed HSVE in apparently immunocompetent children; the presentation was characterized by acute onset of fever, odynophagia, and dysphagia. In two cases, the diagnosis was confirmed histologically by identification of herpes viral inclusions and culture of the virus in the presence of inflammation. The third case was considered to have probable HSVE based on the presence of typical cold sore on his lip, typical endoscopic finding, histopathological evidence of inflammation in esophageal biopsies and positive serologic evidence of acute Herpes simplex virus infection. Two cases received an intravenous course of acyclovir and one had self-limited recovery. All three cases had normal immunological workup and excellent health on long-term follow-up.

  13. Varicella zoster virus-associated morbidity and mortality in Africa: a systematic review protocol

    Science.gov (United States)

    Hussey, Hannah S; Abdullahi, Leila H; Collins, Jamie E; Muloiwa, Rudzani; Hussey, Gregory D; Kagina, Benjamin M

    2016-01-01

    Introduction Varicella zoster virus (VZV) causes varicella (chicken pox) and herpes zoster (shingles). Worldwide, these diseases are associated with significant morbidity. Most of the epidemiological data on VZV come from high income countries. There are few data on VZV in Africa, where tropical climates and high HIV/AIDS prevalence rates are expected to impact the epidemiology of VZV. Safe and effective vaccinations for both varicella and herpes zoster exist, but are not routinely used in Africa. There are very few data available on VZV disease burden in Africa to guide the introduction of these vaccines on the continent. Our aim is to conduct a systematic review of the VZV-associated morbidity and mortality in Africa, which will provide critical information that could be used to develop vaccination policies against these diseases in Africa. Methods and analysis Electronic databases will be searched and all studies published after 1974 that meet predefined criteria will be assessed. The primary outcomes for the study are VZV incidence/prevalence, hospitalisation rates and total death rates. The secondary outcome for this study is the proportion of VZV hospitalisations and/or deaths associated with HIV/AIDS. Two reviewers will screen the titles and abstracts, and then independently review the full texts, to determine if studies are eligible for inclusion. A risk of bias and quality assessment tool will be used to score all included studies. Following standardised data extraction, a trend analysis using R-programming software will be conducted to investigate the trend of VZV. Depending on the characteristics of included studies, subgroup analyses will be performed. This review will be reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Ethics and dissemination As this is a protocol for a systematic review, which will use already published data, no ethics approval is required. Findings will be disseminated

  14. Major depressive disorder and immunity to varicella-zoster virus in the elderly.

    Science.gov (United States)

    Irwin, Michael R; Levin, Myron J; Carrillo, Carmen; Olmstead, Richard; Lucko, Anne; Lang, Nancy; Caulfield, Michael J; Weinberg, Adriana; Chan, Ivan S F; Clair, Jim; Smith, Jeff G; Marchese, R D; Williams, Heather M; Beck, Danielle J; McCook, Patricia T; Johnson, Gary; Oxman, Michael N

    2011-05-01

    Major depressive disorder has been associated with activation of inflammatory processes as well as with reductions in innate, adaptive and non-specific immune responses. The objective of this study was to evaluate the association between major depression and a disease-relevant immunologic response, namely varicella-zoster virus (VZV)-specific immunity, in elderly adults. A cross-sectional cohort study was conducted in 104 elderly community dwelling adults ≥ 60years of age who were enrolled in the depression substudy of the shingles prevention study, a double blind, placebo-controlled vaccine efficacy trial. Fifty-two subjects had a current major depressive disorder, and 52 age- and sex-matched controls had no history of depression or any mental illness. VZV-specific cell-mediated immunity (VZV-CMI) was measured by VZV responder cell frequency (VZV-RCF) and interferon-γ enzyme-linked immunospot (ELISPOT) assays, and antibody to VZV was measured by an enzyme-linked immunosorbent assay against affinity-purified VZV glycoproteins (gpELISA). VZV-CMI, measured by VZV-RCF, was significantly lower in the depressed group than in the controls (pdepressive symptoms in the depressed patients. In addition, an age-related reduction in VZV-RCF was observed in the depressed patients, but not in the controls. Furthermore, there was a trend for depressive symptom severity to be associated with lower ELISPOT counts. Finally, VZV-RCF was higher in depressed patients treated with antidepressant medications as compared to untreated depressed patients. Since lower levels of VZV-RCF appear to explain the increased risk and severity of herpes zoster observed in older adults, these findings suggest that, in addition to increasing age, depression may increase the risk and severity of herpes zoster.

  15. Herpes simplex virus encephalitis in hamadan, iran.

    Directory of Open Access Journals (Sweden)

    Masoud Sabouri Ghannad

    2013-09-01

    Full Text Available Encephalitis can cause a severe public health problem. The main aim of this research was to evaluate the medical laboratory results of patients with Herpes Simplex Virus (HSV encephalitis.Diagnosis of encephalitis for these patients was firstly based on a clinical profile for Herpes Simplex Encephalitis (HSE, plus either a detected HSV1&2-DNA by PCR in CSF or brain neuro-imaging results.Molecular testing on CSF showed that 15 patients (15% had HSV infection, 5 patients (5% had Varicella Zoster Virus (VZV and one case was positive for Human Immunodeficiency Virus (HIV-RNA in CSF. The cause of encephalitis in 79 out of 100 patients (79% was unknown. The comparison of CSF analysis in HSV positives and negatives showed a significant increase of glucose and protein levels in HSV positives than negatives. The mortality rate was 46.6% (7/15 in patients with HSV encephalitis compared to 11.4% (10/85 in non-HSV encephalitis (P = 0.003.In the current study, 15% of cases were diagnosed as having HSV.

  16. Genital herpes - self-care

    Science.gov (United States)

    Herpes - genital -self-care; Herpes simplex - genital - self-care; Herpesvirus 2 - self-care; HSV-2 - self-care ... genital herpes can be treated. Follow your health care provider's instructions for treatment and follow-up.

  17. Advances in Varicella-zoster virus%水痘-带状疱疹病毒研究进展

    Institute of Scientific and Technical Information of China (English)

    高睿迪; 杨慧兰; 刘仲荣; 樊建勇

    2014-01-01

    Varicella and herpes zoster were caused by varicella-zoster virus (VZV), which usually oc-curred in childhood and elddly. Recently many researches have focused on the molecular mechanism, im-mune mechanism and vaccine development of VZV. In this paper we summarize the nosogenesis,immunolog-ical mechanisms and vaccine development of VZV.%水痘-带状疱疹病毒( VZV)可引起水痘及带状疱疹,幼年及老年较常见,目前对其分子机制、免疫机制以及疫苗研发的研究居多。本文针对近年来VZV致病情况、免疫机制及疫苗的相关研究作一综述。

  18. Rapid Detection of Herpes Viruses for Clinical Applications

    Science.gov (United States)

    Pierson, Duane; Mehta, Satish

    2013-01-01

    There are eight herpes viruses that infect humans, causing a wide range of diseases resulting in considerable morbidity and associated costs. Varicella zoster virus (VZV) is a human herpes virus that causes chickenpox in children and shingles in adults. Approximately 1,000,000 new cases of shingles occur each year; post-herpetic neuralgia (PHN) follows shingles in 100,000 to 200,000 people annually. PHN is characterized by debilitating, nearly unbearable pain for weeks, months, and even years. The onset of shingles is characterized by pain, followed by the zoster rash, leading to blisters and severe pain. The problem is that in the early stages, shingles can be difficult to diagnose; chickenpox in adults can be equally difficult to diagnose. As a result, both diseases can be misdiagnosed (false positive/negative). A molecular assay has been adapted for use in diagnosing VZV diseases. The polymerase chain reaction (PCR) assay is a non-invasive, rapid, sensitive, and highly specific method for VZV DNA detection. It provides unequivocal results and can effectively end misdiagnoses. This is an approximately two-hour assay that allows unequivocal diagnosis and rapid antiviral drug intervention. It has been demonstrated that rapid intervention can prevent full development of the disease, resulting in reduced likelihood of PHN. The technology was extended to shingles patients and demonstrated that VZV is shed in saliva and blood of all shingles patients. The amount of VZV in saliva parallels the medical outcome.

  19. Chronic cutaneous varicella zoster virus infection complicating dermatomyositis.

    Science.gov (United States)

    Hoesly, Fridolin J; Sluzevich, Jason C

    2014-04-01

    Chronic cutaneous varicella zoster virus (VZV) infection has not been previously reported or characterized as a complication of dermatomyositis. Two patients with non-malignancy-associated dermatomyositis, treated with long-term prednisone and methotrexate, developed persistent, painless ulcers ultimately established to be secondary to chronic VZV. The absence of pain or a history suggestive of acute VZV, and the lack of characteristic histopathology, resulted in a lengthy delay in diagnosis. Polymerase chain reaction and tissue immunohistochemistry were positive for VZV, and treatment with valacyclovir resulted in complete clearance. Diagnostic testing for VZV should thus be considered in the evaluation of ulcerative lesions in patients with dermatomyositis. The increased incidence of acute VZV in combination with the nature and duration of immunosuppressive treatment in this patient population may be contributory.

  20. 带状疱疹和带状疱疹后遗神经痛——了解可能的病理生理机制,避免盲目治疗%Herpes zoster and postherpetic neuralgia: possible pathophysiological mechanism and avoidance of hasty treatment

    Institute of Scientific and Technical Information of China (English)

    杜冬萍

    2009-01-01

    带状疱疹(herpes zoster,HZ)表现为沿着某一感觉神经分布的疱疹(shingles)和皮肤损害,除了皮肤症状外,剧烈的疼痛是其主要临床表现。皮肤疱疹一般持续1周~1个月,愈合后表皮遗留色素沉着,个别患者可出现瘢痕。

  1. The Variegate Neurological Manifestations of Varicella Zoster Virus Infection

    OpenAIRE

    Gilden, Don; Nagel, Maria A.; Cohrs, Randall J; Ravi MAHALINGAM

    2013-01-01

    Varicella zoster virus (VZV) is an exclusively human neurotropic alphaherpesvirus. Primary infection causes varicella (chickenpox), after which the virus becomes latent in ganglionic neurons along the entire neuraxis. With advancing age or immunosuppression, cell-mediated immunity to VZV declines, and the virus reactivates to cause zoster (shingles), dermatomal distribution, pain, and rash. Zoster is often followed by chronic pain (postherpetic neuralgia), cranial nerve palsies, zoster paresi...

  2. Varicella zoster virus related deaths and hospitalizations before the introduction of universal vaccination with the tetraviral vaccine

    Directory of Open Access Journals (Sweden)

    Alessandra de Martino Mota

    2016-08-01

    Full Text Available Abstract Objective: To characterize varicella zoster virus-related deaths and hospitalizations in Brazil before universal vaccination with the tetravalent (measles, mumps, rubella, and varicella vaccine, attempting to collect baseline data on varicella morbidity and mortality in order to evaluate the impact of the varicella vaccination program. Methods: Varicella-associated mortality data were evaluated between 1996 and 2011 and varicella zoster virus-associated hospitalizations between 1998 and 2013. Data were gathered from the Informatics Department of the Unified Health System, considering the International Classification of Diseases, 10th Revision, code B01. All age groups were assessed. Varicella-specific mortality rates were calculated and seasonality of varicella-zoster virus-associated hospitalizations was described. Results: There were 2334 varicella deaths between 1996 and 2011, 19.3% in infants aged less than 1 year and 36% in children from 1 to 4 years. In infants under 1 year, varicella mortality rates reached 3.2/100,000/year. In children aged 1–4 years, varicella mortality rates reach 1.64/100,000/year. Average annual mortality rates for varicella in Brazil are 0.88/100,000 in infants under 1 year and 0.40/100,000 in children aged 1–4 years. The total number of hospitalizations associated with varicella zoster virus was 62,246 from 2008 to 2013. Varicella-associated hospitalizations have a seasonal distribution in children, peaking in November. In the elderly, monthly averages of herpes zoster-associated hospitalizations present no significant seasonal variation. Conclusions: Varicella is associated, in the pre-vaccine period, to significant morbidity and mortality in Brazil. The universal vaccination program is expected to decrease the disease burden from varicella.

  3. Isolation of a new herpes virus from human CD4 sup + T cells

    Energy Technology Data Exchange (ETDEWEB)

    Frenkel, N.; Schirmer, E.C.; Wyatt, L.S.; Katsafanas, G.; Roffman, E.; Danovich, R.M. (National Institutes of Health, Rockville, MD (USA)); June, C.H. (Naval Medical Research Institute, Bethesda, MD (USA))

    1990-01-01

    A new human herpes virus has been isolated from CD4{sup +} T cells purified from peripheral blood mononuclear cells of a healthy individual (RK), following incubation of the cells under conditions promoting T-cell activation. The virus could not be recovered from nonactivated cells. Cultures of lymphocytes infected with the RK virus exhibited a cytopathic effect, and electron microscopic analyses revealed a characteristic herpes virus structure. RK virus DNA did not hybridize with large probes derived from herpes simplex virus, Epstein-Barr virus, varicella-zoster virus, and human cytomegalovirus. The genetic relatedness of the RK virus to the recently identified T-lymphotropic human herpes virus 6 (HHV-6) was investigated by restriction enzyme analyses using 21 different enzymes and by blot hydridization analyses using 11 probes derived from two strains of HHV-6 (Z29 and U1102). Whereas the two HHV-6 strains exhibited only limited restriction enzyme polymorphism, cleavage of the RK virus DNA yielded distinct patterns. Of the 11 HHV-6 DNA probes tested, only 6 cross-hybridized with DNA fragments derived from the RK virus. Taken together, the maximal homology amounted to 31 kilobases of the 75 kilobases tested. The authors conclude that the RK virus is distinct from previously characterized human herpesviruses. The authors propose to designate it as the prototype of a new herpes virus, the seventh human herpes virus identified to date.

  4. Human herpes simplex labialis.

    Science.gov (United States)

    Fatahzadeh, M; Schwartz, R A

    2007-11-01

    Humans are the natural host for eight of more than 80 known herpes viruses. Infections with herpes simplex virus type 1 (HSV-1) are ubiquitous worldwide and highly transmissible. Herpes simplex labialis (HSL) is the best-recognized recrudescent infection of the lips and perioral tissues caused by HSV-1. Facial lesions of HSL may be unsightly, frequent outbreaks unpleasant, and the infection itself more severe locally and systemically in immunocompromised people. This article highlights the pathogenesis, clinical presentation, diagnostic features and management issues for HSL.

  5. The equine herpes virus 4 thymidine kinase is a better suicide gene than the human herpes virus 1 thymidine kinase.

    Science.gov (United States)

    Loubière, L; Tiraby, M; Cazaux, C; Brisson, E; Grisoni, M; Zhao-Emonet, J; Tiraby, G; Klatzmann, D

    1999-09-01

    The herpes simplex virus type 1 thymidine kinase suicide gene (HSV1tk) together with ganciclovir (GCV) have been successfully used for in vivo treatment of various experimental tumors, and many clinical trials using this system have been launched. With the aim to improve this therapeutic system, we compared the potential efficacy of different herpes virus derived thymidine kinases (HSV1, varicella-zoster virus, equine herpes virus type-4 and Epstein-Barr virus) as suicide genes in association with the nucleoside analogs acyclovir, ganciclovir and bromovinyldeoxyur- idine. Using various murine and human cell lines expressing these viral tk, we show that HSV1- and EHV4tk are the more efficient suicide genes for the different nucleoside analogs tested. Moreover, EHV4tk expressing murine and human cells were three- to 12-fold more sensitive to GCV than HSV1tk expressing cells. This was correlated with the presence of five-fold higher amounts of the toxic triphosphated-GCV in EHV4- versus HSV1tk expressing cells. Altogether, these experiments underline the potential advantages of the EHV4tk as a suicide gene.

  6. Susceptibility of herpes simplex virus isolated from genital herpes lesions to ASP2151, a novel helicase-primase inhibitor.

    Science.gov (United States)

    Katsumata, Kiyomitsu; Weinberg, Adriana; Chono, Koji; Takakura, Shoji; Kontani, Toru; Suzuki, Hiroshi

    2012-07-01

    ASP2151 (amenamevir) is a helicase-primase inhibitor against herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus. To evaluate the anti-HSV activity of ASP2151, susceptibility testing was performed on viruses isolated from patients participating in a placebo- and valacyclovir-controlled proof-of-concept phase II study for recurrent genital herpes. A total of 156 HSV strains were isolated prior to the dosing of patients, and no preexisting variants with less susceptibility to ASP2151 or acyclovir (ACV) were detected. ASP2151 inhibited HSV-1 and HSV-2 replication with mean 50% effective concentrations (EC(50)s) of 0.043 and 0.069 μM, whereas ACV exhibited mean EC(50)s of 2.1 and 3.2 μM, respectively. Notably, the susceptibilities of HSV isolates to ASP2151 and ACV were not altered after dosing with the antiviral agents. Taken together, these results demonstrate that ASP2151 inhibits the replication of HSV clinical isolates more potently than ACV, and HSV resistant to this novel helicase-primase inhibitor as well as ACV may not easily emerge in short-term treatment for recurrent genital herpes patients.

  7. Pregnancy and herpes

    Science.gov (United States)

    ... ill, treatment is often done in the hospital intensive care unit. Outlook (Prognosis) Infants with systemic herpes or ... 2016 Updated by: Daniel N. Sacks, MD, FACOG, obstetrics & gynecology in private practice, West Palm Beach, FL. ...

  8. A rapid radioimmunoassay using /sup 125/I-labeled staphylococcal protein A for antibody to varicella-zoster virus

    Energy Technology Data Exchange (ETDEWEB)

    Richman, D.D.; Cleveland, P.H.; Oxman, M.N.; Zaia, J.A.

    1981-05-01

    A sensitive radioimmunoassay for serum antibody to varicella-zoster virus is described; it uses 125I-labeled staphylococcal protein A and a specially designed immunofiltration apparatus. The assay accurately distinguishes between individuals who are susceptible and those who are immune to infection with varicella-zoster virus. In addition, it can detect passive antibody in recipients of varicella-zoster immune globulin. This radioimmunoassay also detects the heterologous antibody responses that occasionally occur in patients infected with herpes simplex virus, which also have been detected by other antibody assays. The particular advantages of this assay are the use of noninfectious reagents, the speed of execution (less than 3 hr), the requirement for only small quantities of serum (30 microliters), the objectivity of end-point determination, and the capability of screening large numbers of sera. Consequently, this radioimmunoassay is especially useful for the rapid identification of susceptible individuals, which is essential for the appropriate management of patients and hospital personnel after exposure to varicella.

  9. Oesophagobronchial fistula caused by varicella zoster virus in a patient with AIDS: a unique case

    Science.gov (United States)

    Moretti, F; Uberti-Foppa, C; Quiros-Roldan, E; Fanti, L; Lillo, F; Lazzarin, A

    2002-01-01

    Human herpesvirus oesophagitis in human immunodeficiency virus positive patients is caused by cytomegalovirus and herpes simplex virus; no cases of oesophagitis and oesophagobrochial fistula as a result of varicella zoster virus (VZV) have been reported to date. This report describes the case of a patient with a 2–3 mm deep oesophageal ulcer whose viral culture was positive for VZV. The patient was treated with acyclovir with resolution of the symptomatology. After the end of the induction treatment, because of the onset of fever and fits of coughing during eating, the patient underwent oesophagography, which showed an ulcer with an oesophagobronchial fistula in the middle and lower third of the oesophagus. This case report stresses the role of VZV infection as a possible cause of oesophagobronchial fistula, a rare but benign condition in patients with AIDS. PMID:11986352

  10. Varicella-Zoster Virus in Perth, Western Australia: Seasonality and Reactivation.

    Directory of Open Access Journals (Sweden)

    Igor A Korostil

    Full Text Available Identification of the factors affecting reactivation of varicella-zoster virus (VZV largely remains an open question. Exposure to solar ultra violet (UV radiation is speculated to facilitate reactivation. Should the role of UV in reactivation be significant, VZV reactivation patterns would generally be expected to be synchronous with seasonal UV profiles in temperate climates.We analysed age and gender specific VZV notification time series data from Perth, Western Australia (WA. This city has more daily sunshine hours than any other major Australian city. Using the cosinor and generalized linear models, we tested these data for seasonality and correlation with UV and temperature.We established significant seasonality of varicella notifications and showed that while herpes-zoster (HZ was not seasonal it had a more stable seasonal component in males over 60 than in any other subpopulation tested. We also detected significant association between HZ notifications and UV for the entire Perth population as well as for females and males separately. In most cases, temperature proved to be a significant factor as well.Our findings suggest that UV radiation may be important for VZV reactivation, under the assumption that notification data represent an acceptably accurate qualitative measure of true VZV incidence.

  11. No evidence of parvovirus B19, Chlamydia pneumoniae or human herpes virus infection in temporal artery biopsies in patients with giant cell arteritis

    DEFF Research Database (Denmark)

    Helweg-Larsen, J; Tarp, B; Obel, N;

    2002-01-01

    conditions. DNA was extracted from frozen biopsies and PCR was used to amplify genes from Chlamydia pneumoniae, parvovirus B19 and each of the eight human herpes viruses: herpes simplex viruses HSV-1 and 2, Epstein-Barr virus, cytomegalovirus, varicella zoster virus and human herpes viruses HHV-6, -7 and -8......OBJECTIVES: Recent studies have suggested that infective agents may be involved in the pathogenesis of giant cell arteritis (GCA), in particular Chlamydia pneumoniae and parvovirus B19. We investigated temporal arteries from patients with GCA for these infections as well as human herpes viruses...... using the polymerase chain reaction (PCR). METHODS: Thirty temporal artery biopsies from 30 patients suspected of having GCA within a period of 1 yr were examined. Thirteen patients had classical GCA, two had biopsy-negative GCA, 10 patients had polymyalgia rheumatica and five patients had other...

  12. Detection of Varicella Zoster Virus DNA within Lesions and Healed Skin Lesions of Herpes Zoster by PCR

    Institute of Scientific and Technical Information of China (English)

    张美华; 朱文元; 徐美萍

    1997-01-01

    DetectionofVaricelaZosterVirusDNAwithinLesionsandHealedSkinLesionsofHerpesZosterbyPCRZhangMeihua(张美华)ZhuWenyuan(朱文元)XuMeiping...

  13. Protective effect of brown Brazilian propolis against acute vaginal lesions caused by herpes simplex virus type 2 in mice: involvement of antioxidant and anti-inflammatory mechanisms.

    Science.gov (United States)

    Sartori, Gláubia; Pesarico, Ana Paula; Pinton, Simone; Dobrachinski, Fernando; Roman, Silvane Souza; Pauletto, Fernanda; Rodrigues, Luiz Carlos; Prigol, Marina

    2012-01-01

    Propolis has been highlighted for its antioxidant, anti-inflammatory and antiviral properties. The purpose of this study was to investigate if brown Brazilian hydroalcoholic propolis extract (HPE) protects against vaginal lesions caused by herpes simplex virus type 2 (HSV-2) in female BALB/c mice. The treatment was divided in 5 days of pre-treatment with HPE [50 mg · kg(-1), once a day, intragastric (i.g.)], HSV-2 infection [10 µl of a solution 1 × 10(2) plaque-forming unit (PFU · ml(-1) HSV-2), intravaginal inoculation at day 6] and post-treatment with HPE (50 mg · kg(-1)) for 5 days more. At day 11, the animals were killed, and the in vivo analysis (score of lesions) and ex vivo analysis [haematological and histological evaluation; superoxide dismutase (SOD), catalase (CAT) and myeloperoxidase (MPO) activities; reactive species (RS), tyrosine nitration levels, non-protein thiols (NPSH) and ascorbic acid (AA) levels] were carried out. HPE treatment reduced extravaginal lesions and the histological damage caused by HSV-2 infection in vaginal tissues of animals. HPE was able to decrease RS, tyrosine nitration, AA levels and MPO activity. Also, it protected against the inhibition of CAT activity in vaginal tissues of mice. HPE promoted protective effect on HSV-2 infected animals by acting on inflammatory and oxidative processes, and this effect probably is caused by its antioxidant and anti-inflammatory properties.

  14. Decompressive craniectomy in herpes simplex encephalitis

    Directory of Open Access Journals (Sweden)

    Muhammed Jasim Abdul Jalal

    2015-01-01

    Full Text Available Intracranial hypertension is a common cause of morbidity in herpes simplex encephalitis (HSE. HSE is the most common form of acute viral encephalitis. Hereby we report a case of HSE in which decompressive craniectomy was performed to treat refractory intracranial hypertension. A 32-year-old male presented with headache, vomiting, fever, and focal seizures involving the right upper limb. Cerebrospinal fluid-meningoencephalitic profile was positive for herpes simplex. Magnetic resonance image of the brain showed swollen and edematous right temporal lobe with increased signal in gray matter and subcortical white matter with loss of gray, white differentiation in T2-weighted sequences. Decompressive craniectomy was performed in view of refractory intracranial hypertension. Decompressive surgery for HSE with refractory hypertension can positively affect patient survival, with good outcomes in terms of cognitive functions.

  15. Development history of herpes simplex encephalitis

    Directory of Open Access Journals (Sweden)

    Jia-wei WANG

    2014-08-01

    Full Text Available Herpes simplex encephalitis (HSE is an acute central nervous system infection caused by herpes simplex virus (HSV. Early clinical manifestations mainly include fever, headache and unconsciousness; when progressing, psychiatric symptoms can occur. Death or serious neurological sequelae will happen if not treated. With the development of laboratory tests and imaging techniques, the early diagnosis of HSE is possible. Even though imaging with temporal lobe abnormal signal has the implication to HSE, the application of polymerase chain reaction (PCR in detecting HSV DNA in cerebrospinal fluid is currently the "gold standard" to diagnose HSE. Once diagnosed, acyclovir must be given as soon as possible, as delayed treatment will result in a poor outcome. doi: 10.3969/j.issn.1672-6731.2014.08.003

  16. Genital herpes: Heisenberg revisited

    Science.gov (United States)

    Goldmeier, D.

    1998-01-01

    In the confirmation of recurrences of genital herpes, patient defined disease reactivation and virological data hold the scientific high ground. The influence of the psyche on recurrence rates and perception of recurrences has been largely neglected and marginalised up to the present, possibly because research work in that area has been and continues to be of poor calibre. However, neglected psychological variables may render otherwise relevant clinical trials uninterpretable. Psychological aspects of counselling before testing for serum herpes simplex type 2 antibodies are also discussed. 




 PMID:9849561

  17. Ultra-violet radiation is responsible for the differences in global epidemiology of chickenpox and the evolution of varicella-zoster virus as man migrated out of Africa

    Directory of Open Access Journals (Sweden)

    Rice Philip S

    2011-04-01

    Full Text Available Abstract Background Of the eight human herpes viruses, varicella-zoster virus, which causes chickenpox and zoster, has a unique epidemiology. Primary infection is much less common in children in the tropics compared with temperate areas. This results in increased adult susceptibility causing outbreaks, for example in health-care workers migrating from tropical to temperate countries. The recent demonstration that there are different genotypes of varicella-zoster virus and their geographic segregation into tropical and temperate areas suggests a distinct, yet previously unconsidered climatic factor may be responsible for both the clinical and molecular epidemiological features of this virus infection. Presentation of the hypothesis Unlike other human herpes viruses, varicella-zoster virus does not require intimate contact for infection to occur indicating that transmission may be interrupted by a geographically restricted climatic factor. The factor with the largest difference between tropical and temperate zones is ultra-violet radiation. This could reduce the infectiousness of chickenpox cases by inactivating virus in vesicles, before or after rupture. This would explain decreased transmissibility in the tropics and why the peak chickenpox incidence in temperate zones occurs during winter and spring, when ultra-violet radiation is at its lowest. The evolution of geographically restricted genotypes is also explained by ultra-violet radiation driving natural selection of different virus genotypes with varying degrees of resistance to inactivation, tropical genotypes being the most resistant. Consequently, temperate viruses should be more sensitive to its effects. This is supported by the observation that temperate genotypes are found in the tropics only in specific circumstances, namely where ultra-violet radiation has either been excluded or significantly reduced in intensity. Testing the Hypothesis The hypothesis is testable by exposing

  18. Study on Establishment of Traditional Chinese Medicine Diagnosis and Treatment of in AIDS Patients with Herpes Zoster by Questionnaires%基于专家问卷调查建立艾滋病带状疱疹中医诊疗规程的研究

    Institute of Scientific and Technical Information of China (English)

    潘菊华; 黄世敬; 王阶; 吴巍; 薛柳华; 陈宇霞

    2013-01-01

    This study was aimed to establish traditional Chinese medicine (TCM) diagnosis and treatment procedure of varicella zoster virus (VZV) in AIDS, and to construct questionnaires for key points and revision of the procedure. The TCM draft of diagnosis and treatment procedure for VZV in AIDS was established through literature retrieval and peer review. Two rounds of surveys were carried out to investigate the confirmation and advice of in-group specialist to key points of TCM or integrative medicine draft including diagnosis, treatment and nursing. Then, diagnosis and treatment procedure were revised according to survey results. The results showed that the recovery of complete ques-tionnaires in the first-round survey was 96%. More confirmation of specialists were given to concept, clinical feature, cause, mechanism, case history and general examination, diagnostic criteria, syndrome differentiation and treatment of dampness-heat of liver channel syndrome, skin, dietary and psychological nursing, treatment course and therapeutic effect standard. The coefficient of variations (CVs) of experiential effective recipe, moxibustion and massage, auxiliary examination, syndrome differentiation and treatment of dampness stagnancy due to spleen deficiency syndrome and qi stagnation and blood stasis syndrome, and western medicine treatment were large. The weight coefficients of all items were within 0.043 6 and 0.046 2. The Cronbach Coefficient Alpha (CCA) was 0.996 and the split-half reliability R was 0.86. Recovery of complete questionnaires in the second-round survey was 100%. More confirmation of special-ists were given to outline, cause, mechanism, case history and general examination, diagnostic criteria, syndrome dif-ferentiation and treatment of three syndromes, experiential effective recipe, skin, dietary and psychological nursing. The CV was 0. The CV of auxiliary examination, moxibustion and massage was 0.063 8, which was less than those of first-round survey. The

  19. 急性Ⅰ型单纯疱疹病毒感染性脑炎影像学表现%Imaging manifestations of acute viral encephalitis caused by type Ⅰ herpes simplex vi rus

    Institute of Scientific and Technical Information of China (English)

    王成伟; 吴尚锋; 陈松平; 许强宏

    2015-01-01

    OBJECTIVE To explore the various manifestations of imaging of acute type I herpes simplex encephalitis (HSE) under different pathological mechanisms so as to improve the cure rate .METHODS The retrospective anal‐ysis was conducted on clinical data of 16 patients diagnosed to have lesions of cerebral hemorrhage due to HSE dur‐ing 2003-2013 .The patients received imaging examination .All the 16 HSE patients were first examined by CT , then 7 of them were examined by MRI according to disease condition .The various important manifestations were summarized and analyzed in combination with literature researches .RESULTS In the early period of onset (30 min‐2 h of onset) ,CT imaging showed slightly increased density of basal ganglia and highlighted signs of basal gan‐glia ,i .e .,prominent sign of basal ganglia .Tiny lesions and small hemorrhage herpetiformis ,which might be typ‐ical ,occurred in basal ganglia ,gray matter and the junction area of gray matter and white matter .Leukodystrophy in temporal lobe was manifested as edema and degeneration‐like changes presented as low density by CT and long T1 and long T2 signal by MRI ,i .e .,the'knife'sign ,which mainly occurred in temporal lobe ,but basal ganglia was not involved .It was recognized as a typical sign .CONCLUSION By imaging diagnosis combined with a variety of test techniques ,some characteristic images of HSE manifestations caused by herpes simplex virus (HSV) infec‐tion were summarized ,which is important for imaging diagnosis of HSE ,especially for the early diagnosis and has certain significance for reducing the mortality and the disability of HSE patients .%目的:探讨急性Ⅰ型单纯疱疹病毒性脑炎(Herpes Simplex Virus Encephalitis ,HSE)不同病理机制多种影像学表现,以提高治愈率。方法回顾性分析2003-2013年16例确诊 HSE有脑出血病灶的患者临床资料,对其进行影像学检查,16例 HSE患者均先行CT

  20. Herpes simplex-encefalitis

    DEFF Research Database (Denmark)

    Jørgensen, Laura Krogh; Mogensen, Trine Hyrup

    2017-01-01

    Herpes simplex encephalitis (HSE) is a rare disease, although it is the most common form of sporadic encephalitis worldwide. Recently, studies have provided important new insight into the genetic and immunological basis of HSE. However, even in the presence of antiviral treatment, mortality and m...

  1. Can You Get Genital Herpes from a Cold Sore?

    Science.gov (United States)

    ... Lucy* Yes — it is possible to get genital herpes from oral sex. Genital herpes is caused by the herpes ... Genital herpes is usually caused by HSV-2; oral herpes (cold sores) is usually caused by HSV-1. ...

  2. Clinic Characteristics of Varicella Zoster Myocarditis

    Institute of Scientific and Technical Information of China (English)

    FANG; Wu-wang

    2001-01-01

    [1]Kokstein Z, Balatka J, Horacek J. ECG changes in children with acute myocarditis[J]. Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove Suppl, 1990, 33(4): 373-379.[2]Rich R, McErlean M. Complete heart block in a child with varicella[J]. Am J Emerg M, 1993, 11(6): 602-605.[3]Sobrino MJM, Lopez PF, Cisneros JM, et al. Thoracic pain as early clinical manifestation of myocarditis caused by varicella [J]. Med Clin Barc,1992, 99(6): 236-237.[4]Teravanichpong S, Chuangsuwanich T. Fatal varicella in a healthy girl[J]. J Med Assoc Thai, 1990, 73(11): 648-651.[5]Amral FT, Bestetti RB, Araujo RC, et al. Transient atroventricular conduction disordor: a potential cause of sudden death in myocarditis due to varicella[J]. Arq Bras Cardiol, 1989, 53(2): 129-131.[6]Lorber A, Zonis Z, Maisuls E, et al. The scale of myocardial involvement in varicella myocarditis[J]. Int J Cardiol,1988, 20(2): 257-262.[7]Ettedgui JA, Ladusans E, Bamford M. Complete heart block as a complication of varicella[J]. Int J Cardiol, 1987, 14(3): 362-365.[8]Waagner DC, Murphy TV. Varicella myocarditis[J]. Pediatr Infect Dis J, 1990, 9(5): 360-363.[9]Rivera CF, Omar M, Aliaga ML, et al. Varicella complicated by pericarditis and pneumonia [J]. An Med Interna, 1996, 13(3): 130-132.[10]Civico RF, Omar M, Martinez LA, et al. Varicella complicated by pericarditis and pneumonia [J]. An Med Interna, 1996, 13(3): 130-132.[11]Bachli E, Kagi MK, Krause M. Visceral and neurological complications in varicella infections of adults [J]. Schweiz Med Wochenschr, 1996, 126(11): 440-446.[12]Senellart F, Bozio A, Sassolas F, et al. Varicella myocarditis and junctional ectopic tachycardia [J]. Pediatrie Bucur, 1991, 46(3): 267-270.[13]Straus S, Ostrove J, Inchauspe G, et al. Varicella- zoster virus infections[J]. Ann Intern Med,1988, 108: 221-237.[14]Tsintsof A, Delprado WJ, Keogh AM. Varicella zoster myocarditis progressing to cardiomyopathy and cardiac

  3. The role of solar ultraviolet irradiation in zoster.

    Science.gov (United States)

    Zak-Prelich, M.; Borkowski, J. L.; Alexander, F.; Norval, M.

    2002-01-01

    Ultraviolet radiation (UVR) suppresses many aspects of cell-mediated immunity but it is uncertain whether solar UV exposure alters resistance to human infectious diseases. Varicella-zoster virus (VZV) causes varicella (chickenpox) and can reactivate from latency to cause zoster (shingles). The monthly incidence of chickenpox and zoster in a defined Polish population over 2 years was recorded and ground level solar UV was measured daily. There was a significant seasonality of UVR. Evidence of seasonal variation was found for all zoster cases and for zoster in males, with the lowest number of cases in the winter. The number of zoster cases with lesions occurring on exposed body sites (the face) demonstrated highly significant seasonality with a peak in July/August. Seasonal models for UVR and zoster cases showed similar temporal patterns. By contrast, for varicella, the maximum number of cases was found in March and the minimum in August/September, probably explained by the respiratory spread of VZV. It is tempting to speculate that the increase in solar UVR in the summer could induce suppression of cellular immunity, thus contributing to the corresponding rise in the incidence of zoster. PMID:12558343

  4. Recrudescent herpes labialis mimicking primary herpes labialis in pregnancy

    OpenAIRE

    Shaveta Sood; Aneet Mahendra; Sanjeev Gupta; Shalu Chandna; Sarabjit Kaur

    2010-01-01

    Context: Herpes simplex virus (HSV) infection is prevalent worldwide. Herpes labialis is caused predominantly by HSV-1, and herpes vulvo-vaginitis is caused predominantly by HSV-2. HSV-2 may result in significant morbidity and mortality for infected neonates exposed during delivery .Due to this fact, a large amount of literature exists for HSV-2 but data for HSV -1 is scanty. Case Report : We report two cases of recrudescent herpes labialis in 3 rd trimester of pregnancy with extensive peri-o...

  5. Genital herpes: Heisenberg revisited

    OpenAIRE

    Goldmeier, D

    1998-01-01

    In the confirmation of recurrences of genital herpes, patient defined disease reactivation and virological data hold the scientific high ground. The influence of the psyche on recurrence rates and perception of recurrences has been largely neglected and marginalised up to the present, possibly because research work in that area has been and continues to be of poor calibre. However, neglected psychological variables may render otherwise relevant clinical trials uninterpretable. Psycholog...

  6. Latent Herpes Viral Reactivation in Astronauts

    Science.gov (United States)

    Pierson, D. L.; Mehta, S. K.; Stowe, R.

    2008-01-01

    Latent viruses are ubiquitous and reactivate during stressful periods with and without symptoms. Latent herpes virus reactivation is used as a tool to predict changes in the immune status in astronauts and to evaluate associated health risks. Methods: Viral DNA was detected by real time polymerase chain reaction in saliva and urine from astronauts before, during and after short and long-duration space flights. Results and Discussion: EpsteinBarr virus (EBV), cytomegalovirus (CMV), and varicella zoster virus (VZV) reactivated, and viral DNA was shed in saliva (EBV and VZV) or urine (CMV). EBV levels in saliva during flight were 10fold higher than baseline levels. Elevations in EBV specific CD8+ T-cells, viral antibody titers, and specific cytokines were consistent with viral reactivation. Intracellular levels of cytokines were reduced in EBVspecific Tcells. CMV, rarely present in urine of healthy individuals, was shed in urine of 27% of astronauts during all phases of spaceflight. VZV, not found in saliva of asymptomatic individuals, was found in saliva of 50% of astronauts during spaceflight and 35 days after flight. VZV recovered from astronaut saliva was found to be live, infectious virus. DNA sequencing demonstrated that the VZV recovered from astronauts was from the common European strain of VZV. Elevation of stress hormones accompanied viral reactivation indicating involvement of the hypothalmic-pituitary-adrenal and sympathetic adrenal-medullary axes in the mechanism of viral reactivation in astronauts. A study of 53 shingles patients found that all shingles patients shed VZV DNA in their saliva and the VZV levels correlated with the severity of the disease. Lower VZV levels in shingles patients were similar to those observed in astronauts. We proposed a rapid, simple, and cost-effective assay to detect VZV in saliva of patients with suspected shingles. Early detection of VZV infection allows early medical intervention.

  7. Sero-Prevalence of Antibodies against Varicella Zoster Virus in Children under Seven-Years Old in 2012 in Tehran, Iran.

    Directory of Open Access Journals (Sweden)

    Yasaman Vojgani

    2014-11-01

    Full Text Available Varicella zoster virus (VZV is a member of herpes family viruses, which causes varicella (chickenpox after primary infection and herpes zoster (shingles because of latent virus reactivation from dorsal root ganglia. Generally, prevalence of varicella antibodies increases with age. We aimed to compare the prevalence of anti-VZV antibody in children under seven years old, in order to obtain a preliminarily picture of general presence of these antibodies to design an immunization plan.In this cross-sectional study, performed from September 2011 to September 2012 in Tehran, Iran, 267 serum samples including sera from 7 month old infants, n= 87; 18 month old children, n= 86; and 6 year old children, n= 94 were assessed for the presence of specific IgG antibodies against VZV, using ELISA technique.4.6% of 7 month, 12.8% of 18 month and 21.3% of 6-year-old children were seropositive. No relation was found between demographic variables (e.g. age and birth weight and seropositivity in these age groups. VZV antibodies increased with age. Serum levels of varicella antibodies were elevated in 18 months old compared to 7 months old children, significantly (P < 0.001.In view of the significant elevation of VZV antibodies in children from 7 months to 18 months of age and rate of seronegative children, our results support the necessity of varicella immunization between 7 and 18 months of age in order to prevent viral infection.

  8. Recrudescent herpes labialis mimicking primary herpes labialis in pregnancy

    Directory of Open Access Journals (Sweden)

    Shaveta Sood

    2010-01-01

    Full Text Available Context: Herpes simplex virus (HSV infection is prevalent worldwide. Herpes labialis is caused predominantly by HSV-1, and herpes vulvo-vaginitis is caused predominantly by HSV-2. HSV-2 may result in significant morbidity and mortality for infected neonates exposed during delivery .Due to this fact, a large amount of literature exists for HSV-2 but data for HSV -1 is scanty. Case Report : We report two cases of recrudescent herpes labialis in 3 rd trimester of pregnancy with extensive peri-oral lesions resembling primary herpes labialis. There was no obvious cause of immunosupression. The patients were followed up with a normal outcome of pregnancy and no fetal abnormality. Conclusions : The reasons for such extensive perioral lesions are uncertain. Immunosupression of pregnancy may be a factor in a sub group of patients.

  9. Recrudescent herpes labialis mimicking primary herpes labialis in pregnancy

    Directory of Open Access Journals (Sweden)

    Shaveta Sood

    2010-10-01

    Full Text Available Context: Herpes simplex virus (HSV infection is prevalent worldwide. Herpes labialis is caused predominantly by HSV-1, and herpes vulvo-vaginitis is caused predominantly by HSV-2. HSV-2 may result in significant morbidity and mortality for infected neonates exposed during delivery. Due to this fact, a large amount of literature exists for HSV-2 but data for HSV -1 is scanty. Case Report: We report two cases of recrudescent herpes labialis in 3rd trimester of pregnancy with extensive peri-oral lesions resembling primary herpes labialis. There was no obvious cause of immunosupression. The patients were followed up with a normal outcome of pregnancy and no fetal abnormality. Conclusions: The reasons for such extensive perioral lesions are uncertain. Immunosupression of pregnancy may be a factor in a sub group of patients.

  10. A systematic approach for the identification of novel, serologically reactive recombinant Varicella-Zoster Virus (VZV antigens

    Directory of Open Access Journals (Sweden)

    Lueking Angelika

    2010-07-01

    Full Text Available Abstract Background Varicella-Zoster virus causes chickenpox upon primary infection and shingles after reactivation. Currently available serological tests to detect VZV-specific antibodies are exclusively based on antigens derived from VZV-infected cells. Results We present a systematic approach for the identification of novel, serologically reactive VZV antigens. Therefore, all VZV open reading frames were cloned into a bacterial expression vector and checked for small scale recombinant protein expression. Serum profiling experiments using purified VZV proteins and clinically defined sera in a microarray revealed 5 putative antigens (ORFs 1, 4, 14, 49, and 68. These were rearranged in line format and validated with pre-characterized sera. Conclusions The line assay confirmed the seroreactivity of the identified antigens and revealed its suitability for VZV serodiagnostics comparable to commercially available VZV-ELISA. Recombinant ORF68 (gE proved to be an antigen for high-confidence determination of VZV serostatus. Furthermore, our data suggest that a serological differentiation between chickenpox and herpes zoster may be possible by analysis of the IgM-portfolio against individual viral antigens.

  11. 水痘-带状疱疹疫苗的使用现状及研究进展%Application and progress in development of varicella-zoster virus

    Institute of Scientific and Technical Information of China (English)

    吴根鹏

    2016-01-01

    水痘-带状疱疹病毒(varicella-zoster virus,VZV)可引起水痘和带状疱疹(herpes zoster,HZ),具有较高的传染性和发病率.目前V-Oka减毒株是WHO推荐的唯一可用于疫苗生产的毒株.自上市以来,水痘疫苗证实了其良好的有效性和安全性.水痘-带状疱疹疫苗的开发及应用受到国内外生物制药企业的广泛重视.本文现就水痘和HZ的流行病学、疫苗的发展和现状作一综述.

  12. Herpes viruses and human papilloma virus in nasal polyposis and controls

    Directory of Open Access Journals (Sweden)

    Dimitrios Ioannidis

    2015-12-01

    Full Text Available ABSTRACT INTRODUCTION: Chronic rhinosinusitis with nasal polyps is a multifactorial disease entity with an unclear pathogenesis. Contradictory data exist in the literature on the potential implication of viral elements in adult patients with chronic rhinosinusitis. OBJECTIVE: To compare the prevalence of human herpes viruses (1-6 and Human Papilloma Virus in adult patients with chronic rhinosinusitis with nasal polyps and healthy controls. METHODS: Viral DNA presence was evaluated by real-time polymerase chain reaction application to nasal polyps specimens from 91 chronic rhinosinusitis with nasal polyps patients and nasal turbinate mucosa from 38 healthy controls. RESULTS: Epstein-Barr virus positivity was higher in nasal polyps (24/91; 26.4% versus controls (4/38; 10.5%, but the difference did not reach significance (p = 0.06. Human herpes virus-6 positivity was lower in nasal polyps (13/91; 14.29% versus controls (10/38; 26.32%,p = 0.13. In chronic rhinosinusitis with nasal polyps group, 1 sample was herpes simplex virus-1-positive (1/91; 1.1%, and another was cytomegalovirus-positive (1/91; 1.1%, versus none in controls. No sample was positive for herpes simplex virus-2, varicella-zoster virus, high-risk-human papilloma viruses (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and low-risk-human papilloma viruses (6, 11. CONCLUSION: Differences in Epstein-Barr virus and human herpes virus-6 positivity among patients with chronic rhinosinusitis with nasal polyps and healthy controls are not statistically significant, weakening the likelihood of their implication in chronic rhinosinusitis with nasal polyps pathogenesis.

  13. Herpes zoster-associeret morbiditet hos børn i kemoterapi for akut lymfoblastaer leukaemi

    DEFF Research Database (Denmark)

    Sørensen, Gitte Vrelits; Helgestad, Jon; Rosthøj, Steen

    2009-01-01

    receiving chemotherapy. All eruptions were treated with acyclovir, in eight cases intravenously, and in six cases chemotherapy was interrupted. Cutaneous dissemination occurred in two cases, visceral dissemination in none. One child had postherpetic trigeminal neuralgia for two months. The eruption rate...

  14. TREATMENT OF HERPES ZOSTER-INDUCED NEURAGIA WITH BLOOD-LETTING, CUPPING PLUS ACUPUNCTURE

    Institute of Scientific and Technical Information of China (English)

    蔡志红; 贺普仁

    2003-01-01

    Professor HE Pu-ren has engaged in acupuncture clinic for more than 50 years and created a specific therapy- "San Tong Fa" (triple dredging needling) for treating various diseases. It is mainly employed to regulate and normalize functional activities of qi, and to cure diseases at last. In the treatment of some refractory diseases, his "San Tong Fa" has new improvement and further development.

  15. 双侧带状疱疹案%Case of bilateral herpes zoster

    Institute of Scientific and Technical Information of China (English)

    艾明媚; 张品; 李岩

    2010-01-01

    @@ The patient, female, 56 years old, born in Jilin provine, northeast of China, paid her first visit to Tianjing Public Security Hospital on August 24,2009. Main complaints: blisters and pain on left chest and back, right flank and hypochondriac region for over 10 days. Medical history: burning pain on left shoulder and back without any obvious precipitating cause 10 days ago. Agminate and red papulo-vesicles from the size of millet to green bean appeared along the 4th intercostals space on the back the next day.

  16. Occasional presence of herpes viruses in synovial fluid and blood from patients with rheumatoid arthritis and axial spondyloarthritis.

    Science.gov (United States)

    Burgos, Rubén; Ordoñez, Graciela; Vázquez-Mellado, Janitzia; Pineda, Benjamín; Sotelo, Julio

    2015-10-01

    Viral agents have been suspected as participants of immune-mediated disorders. In the case of rheumatic diseases, the synovial joint cavity represents a secluded area of inflammation which could harbor etiological agents. We analyzed by polymerase chain reaction the possible presence of DNA from various herpes viruses in blood and synovial fluid from patients with either rheumatoid arthritis (n = 18), axial spondyloarthritis (n = 11), or osteoarthritis (n = 8). Relevant findings were as follows: DNA from varicella zoster virus was found in synovial fluid but not in blood mononuclear cells from 33 % of patients with rheumatoid arthritis and in 45 % of patients with axial spondyloarthritis but not in patients with osteoarthritis. Also, DNA from herpes simplex viruses 1 and 2 was found both in the blood and in the synovial fluid from 33 % of patients with rheumatoid arthritis. Our results indicate the occasional presence of DNA from herpes viruses in patients with rheumatoid arthritis or with axial spondyloarthritis. However, these findings might represent a parallel epiphenomenon of viral activation associated either with immunosuppressive therapy or with primary immune disturbances, rather than the etiological participation of herpes viruses in these disorders.

  17. The Significance of Herpes Simplex for School Nurses

    Science.gov (United States)

    Ensor, Deirdre

    2005-01-01

    Herpes simplex is a common recurrent viral infection caused by the herpes simplex virus. The two closely related but distinct viruses that cause herpes simplex infections are herpes simplex 1 (HSV-1) and herpes simplex 2 (HSV-2). HSV-1 is commonly associated with infections around the oral mucosa and is the cause of herpes labialis, often referred…

  18. Comparison of indirect immunofluorescence and radioimmunoassay for detecting antibody to varicella-zoster virus

    Energy Technology Data Exchange (ETDEWEB)

    Campbell-Benzie, A.; Heath, R.B.; Ridehalgh, M.K.S.; Cradock-Watson, J.E. (Saint Bartholomew' s Hospital, London (UK))

    1983-03-01

    Immunofluorescence (IF) and radioimmunoassay (RIA) were found to be more sensitive methods than complement fixation (CF) for detecting antibody to varicella-zoster (V-Z) virus. RIA yielded titres about 30 times greater than those obtained by IF, but for screening purposes RIA was only about six times more sensitive since the minimum serum dilutions that could be tested were 1/100 and 1/16 respectively. When 539 sera from subjects of different ages were screened for V-Z antibody, IF and RIA gave concordant results with 527 specimens (98%). When 19 patients were tested who had not previously had varicella but were experiencing primary infection with herpes simplex (HS) virus, crossreacting antibodies to V-Z antigens were detected in six patients by IF but in only two of these by RIA. IF and RIA are preferable to CF as tests for immune status because of their greater sensitivity, but weak positive reactions caused by presumptive low titres of homologous antibody or by higher titres of heterologous antibody can occur in one or both tests. Such reactions could cause difficulty in assessing the need for vaccine or for specific immune globulin, and in interpreting the response to vaccination.

  19. Varicella-Zoster Virus Keratitis with Asymptomatic Conjunctival Viral Shedding in the Contralateral Eye

    Directory of Open Access Journals (Sweden)

    Akio Miyakoshi

    2012-10-01

    Full Text Available Purpose: To report a case of varicella-zoster virus (VZV keratitis with detection of VZV DNA in the tear fluid of not only the symptomatic eye but also the contralateral asymptomatic eye by polymerase chain reaction (PCR. Methods: This is a case report. A 63-year-old otherwise healthy woman presented with circular corneal ulcer and stromal opacity with infiltration accompanied by mild conjunctival and ciliary injections in the left eye. Bacterial cultures of the corneal scrapings and virus PCR analyses of tear fluid from both eyes were performed. Results: No pathogen was found by bacterial cultures. PCR was negative for Acanthamoeba, herpes simplex virus and cytomegalovirus, but positive for VZV. VZV DNA was also detected in the unaffected eye. Based on the diagnosis of VZV keratitis, oral valacyclovir and acyclovir eye ointment were administered to the corneal infected eye. The infected eye was healed and VZV DNA turned negative in the tear fluid of the treated eye after 6 months of treatment; however, VZV DNA was still positive in the tear fluid of the contralateral eye. Conclusions: To our knowledge, this is the first case report of the detection of VZV DNA in the tear fluid of both affected and unaffected eyes in a patient with VZV keratitis. Asymptomatic conjunctival shedding of VZV may continue in the healthy unaffected eye in VZV keratitis patients.

  20. 成人水痘合并带状疱疹1例并文献复习%Adult Varicella Zoster Merger Case Report and Literature Review

    Institute of Scientific and Technical Information of China (English)

    陈日新

    2014-01-01

    目的:了解我国临床水痘合并带状疱疹的临床表型特点及诊治相关问题。方法对1例典型水痘合并带状疱疹患者的诊治过程进行详细报道,并对近年国内发表的资料完整的22例水痘合并带状疱疹患者进行综合对比分析。结果给予静滴膦甲酸钠注射液250ml及神经妥乐平针7.2U Qd,口服维生素 B1片20mg tid,甲钴胺片500ug tid,加巴喷丁胶囊0.3 tid,局部外用炉甘石洗剂及氦-氖激光照射。结论7d后,患者皮疹逐渐消退,水疱大部分结痂,无局部疼痛及小便刺痛不适。10d后痊愈出院。%Objective To understand the clinical features,phenotypes,diagnosis and treatment of Chinese patients with Varicel a and Herpes Zoster.Methods We analyze and report detail clinical information of a young man patient with typical Varicel a and Herpes Zoster,and perform a meta-analysis for other 22 selected patients with Varicel a and Herpes Zoster reported in recent 10 years. Results Given intravenous foscarnet injection 250ml and Neurotropin needle 7.2U Qd, oral vitamin B1 tablets 20mg tid, mecobalamin piece 500ug tid, gabapentin capsules 0.3 tid, topical calamine lotion and helium-neon laser ir adiation. Conclusion After 7 days, the patient gradual y subsided rash, blisters scab majority, no local pain and tingling discomfort urinating. 10 days later discharged.

  1. Viral aetiology and clinico-epidemiological features of acute encephalitis syndrome in eastern India.

    Science.gov (United States)

    Rathore, S K; Dwibedi, B; Kar, S K; Dixit, S; Sabat, J; Panda, M

    2014-12-01

    This study reports clinico-epidemiological features and viral agents causing acute encephalitis syndrome (AES) in the eastern Indian region through hospital-based case enrolment during April 2011 to July 2012. Blood and CSF samples of 526 AES cases were investigated by serology and/or PCR. Viral aetiology was identified in 91 (17·2%) cases. Herpes simplex virus (HSV; types I or II) was most common (16·1%), followed by measles (2·6%), Japanese encephalitis virus (1·5%), dengue virus (0·57%), varicella zoster virus (0·38%) and enteroviruses (0·19%). Rash, paresis and cranial nerve palsies were significantly higher (P Case-fatality rates were 10·9% and 6·2% in AES cases with and without viral aetiology, respectively. Simultaneous infection of HSV I and measles was observed in seven cases. This report provides the first evidence on viral aetiology of AES viruses from eastern India showing dominance of HSV that will be useful in informing the public health system.

  2. A rare cause of dysphagia: Herpes simplex esophagitis

    Institute of Scientific and Technical Information of China (English)

    Bee Lee; Grant Caddy

    2007-01-01

    Herpes simplex esophagitis (HSE) is well documented in immunosuppressed patients. However, it is rare in the immunocompetent host. We present a case of HSE in a 21 year-old healthy lady who was admitted to our unit with dysphagia, odynophagia and chest pAln. Clinical examination revealed mild epigastric tenderness and admission bloods including full blood picture, electrolytes and inflammatory markers were normal. She underwent an esophagogastroduodenoscopy (EGD) which revealed severe exudative, well-circumscribed ulcerations in her distal esophagus. Biopsies confirmed severe esophagitis with acute ulceration and subsequent polymerase chAln reaction (PCR) confirmed herpes simplex virus (HSV) type 1. Subsequent assessment fAlled to identify an immune disorder. HSE should be suspected when faced with characteristic endoscopic findings, even if the patient is immunocompetent. When the diagnosis of HSE is confirmed, an immune deficiency should be sought.

  3. Direct transfer of viral and cellular proteins from varicella-zoster virus-infected non-neuronal cells to human axons.

    Directory of Open Access Journals (Sweden)

    Sergei Grigoryan

    Full Text Available Varicella Zoster Virus (VZV, the alphaherpesvirus that causes varicella upon primary infection and Herpes zoster (shingles following reactivation in latently infected neurons, is known to be fusogenic. It forms polynuclear syncytia in culture, in varicella skin lesions and in infected fetal human ganglia xenografted to mice. After axonal infection using VZV expressing green fluorescent protein (GFP in compartmentalized microfluidic cultures there is diffuse filling of axons with GFP as well as punctate fluorescence corresponding to capsids. Use of viruses with fluorescent fusions to VZV proteins reveals that both proteins encoded by VZV genes and those of the infecting cell are transferred in bulk from infecting non-neuronal cells to axons. Similar transfer of protein to axons was observed following cell associated HSV1 infection. Fluorescence recovery after photobleaching (FRAP experiments provide evidence that this transfer is by diffusion of proteins from the infecting cells into axons. Time-lapse movies and immunocytochemical experiments in co-cultures demonstrate that non-neuronal cells fuse with neuronal somata and proteins from both cell types are present in the syncytia formed. The fusogenic nature of VZV therefore may enable not only conventional entry of virions and capsids into axonal endings in the skin by classical entry mechanisms, but also by cytoplasmic fusion that permits viral protein transfer to neurons in bulk.

  4. Analysis of Enzymatic Digestion Pattern of Two Open Reading Frames of Varciella–Zoster Genome from Kuwaiti Patients Using the RFLP Technique

    Directory of Open Access Journals (Sweden)

    Jafar A Qasem

    2012-12-01

    Full Text Available Background and Objectives: Varicella–Zoster virus (VZV is a human herpes virus that usually attacks young children and commonly causes chicken pox (Varicella. Following primary infection, a lifelong latent infection is established. The virus often reactivates during adulthood or senesces to cause shingles (Zoster. Little is known regarding the genotypes of Varicella in Kuwait. The aim of this study was to genotype Varicella samples collected from patients in Kuwait.Materials and Methods: Samples from 60 cases of chicken pox were typed. The DNA extraction was performed using the commercially available DNA extraction kit. Two sets of oligonucleotide primers were used to amplify the intervening sequences with polymerase chain reaction to identify VZV DNA in clinical samples. The BglI and PstI endonucleases were used to digest. The PCR amplicons for PCR-RFLP typing.Results: Relatively consistent restriction enzyme digestion profiles for different VZV strains were observed. Limited genetic differences between VZV samples were found. Three VZV strains were identified (A, B and C with type B representing 86.6%, type A 11.7% and type C being 1.7%. We found that distinct restriction fragment length polymorphism isolates from the same origin or nationality were very similar.Conclusion: Varicella strains with cutting sites for both enzyme PstI and BglI (typeB were more prevalent. Molecular amplification of viral DNA by PCR and restriction digestion could be used for VZV typing as an alternative method to serological assays.

  5. Direct transfer of viral and cellular proteins from varicella-zoster virus-infected non-neuronal cells to human axons.

    Science.gov (United States)

    Grigoryan, Sergei; Yee, Michael B; Glick, Yair; Gerber, Doron; Kepten, Eldad; Garini, Yuval; Yang, In Hong; Kinchington, Paul R; Goldstein, Ronald S

    2015-01-01

    Varicella Zoster Virus (VZV), the alphaherpesvirus that causes varicella upon primary infection and Herpes zoster (shingles) following reactivation in latently infected neurons, is known to be fusogenic. It forms polynuclear syncytia in culture, in varicella skin lesions and in infected fetal human ganglia xenografted to mice. After axonal infection using VZV expressing green fluorescent protein (GFP) in compartmentalized microfluidic cultures there is diffuse filling of axons with GFP as well as punctate fluorescence corresponding to capsids. Use of viruses with fluorescent fusions to VZV proteins reveals that both proteins encoded by VZV genes and those of the infecting cell are transferred in bulk from infecting non-neuronal cells to axons. Similar transfer of protein to axons was observed following cell associated HSV1 infection. Fluorescence recovery after photobleaching (FRAP) experiments provide evidence that this transfer is by diffusion of proteins from the infecting cells into axons. Time-lapse movies and immunocytochemical experiments in co-cultures demonstrate that non-neuronal cells fuse with neuronal somata and proteins from both cell types are present in the syncytia formed. The fusogenic nature of VZV therefore may enable not only conventional entry of virions and capsids into axonal endings in the skin by classical entry mechanisms, but also by cytoplasmic fusion that permits viral protein transfer to neurons in bulk.

  6. Varicella-zoster-infektion kompliceret med bakteriel pneumoni hos barn

    DEFF Research Database (Denmark)

    Wolthers, Benjamin Ole; Thiested, Ebbe; Gyhrs, Anette F

    2015-01-01

    This case report describes how a three-year-old girl referred to our paediatric ward, infected with varicella-zoster virus and a bacterial pneumonia causing atelectasis. The girl did not respond to initial treatment with intravenous antibiotics. Only after a lung drain was inserted she gradually ...

  7. Vesicles

    Science.gov (United States)

    ... poison ivy) Herpes simplex (cold sores, genital herpes ) Herpes zoster (shingles) Impetigo Fungal infections Burns Home Care It ... disease on the soles Herpes simplex - close-up Herpes zoster (shingles) - close-up of lesion Poison ivy on ...

  8. Ocular herpes:the pathophysiology,management and treatment of herpetic eye diseases

    Institute of Scientific and Technical Information of China (English)

    Lucy; Zhu; Hua; Zhu

    2014-01-01

    Herpesviruses are a prominent cause of human viral disease, second only to the cold and influenza viruses. Most herpesvirus infections are mild or asymptomatic. However, when the virus invades the eye, a number of pathologies can develop and its associated sequelae have become a considerable source of ocular morbidity. The most common culprits of herpetic eye disease are the herpes simplex virus(HSV), varicella zoster virus(VZV), and cytomegalovirus(CMV). While primary infection can produce ocular disease, the most destructive manifestations tend to arise from recurrent infection. These recurrent infections can wreck devastating effects and lead to irreversible vision loss accompanied by a decreased quality of life, increased healthcare usage, and significant cost burden. Unfortunately, no method currently exists to eradicate herpesviruses from the body after infection. Treatment and management of herpes-related eye conditions continue to revolve around antiviral drugs, although corticosteroids, interferons, and other newer therapies may also be appropriate depending on the disease presentation. Ultimately, the advent of effective vaccines will be crucial to preventing herpesvirus diseases altogether and cutting the incidence of ocular complications.

  9. Reactivation of latent herpes viruses in cosmonauts during a soyuz taxi mission

    Science.gov (United States)

    Mehta, Satish K.; Pierson, Duane L.

    2007-09-01

    The hypothesis tested by this project is that space flight increases the incidence and duration of herpes virus reactivation and shedding in saliva. Saliva, urine, and blood samples were collected from 3 crew members who participated in a 14-day Odessa Soyuz taxi mission. Saliva samples were collected before, during, and after the mission, and blood and urine were collected before and after the mission. The saliva and urine samples were analyzed using the polymerase chain reaction to detect the presence of 3 important herpes viruses. Epstein-Barr virus (EBV) and varicella-zoster virus (VZV) were tested in saliva, and cytomegalovirus (CMV) was measured in urine samples. Plasma antibodies levels to these viruses were determined by enzyme-linked immunosorbent assay before and after flight. EBV reactivated before, during, and after flight; CMV reactivated before and after flight; and VZV reactivated during and after flight. In other studies, greater frequencies of positive samples and greater numbers of copies of viral DNA have been found. No increases in titer of antibodies to these viruses were found, suggesting that an immune response may not be necessary for reactivation.

  10. Seronegative Herpes simplex Associated Esophagogastric Ulcer after Liver Transplantation

    Directory of Open Access Journals (Sweden)

    Edouard Matevossian

    2008-03-01

    Full Text Available Herpes simplex infection is characterized by acute or subacute infection, often followed by a chronic carrier state. Consecutive recurrences may flare up if immunocompromise occurs. Herpes simplex associated esophagitis or duodenal ulcer have been reported in immunocompromised patients due to neoplasm, HIV/AIDS or therapeutically induced immune deficiency. Here we report the case of an HSV-DNA seronegative patient who developed grade III dysphagia 13 days after allogeneic liver transplantation. Endoscopy revealed an esophageal-gastric ulcer, and biopsy histopathology showed a distinct fibroplastic and capillary ulcer pattern highly suspicious for viral infection. Immunohistochemistry staining revealed a distinct nuclear positive anti-HSV reaction. Antiviral therapy with acyclovir and high-dose PPI led to a complete revision of clinical symptoms within 48 h. Repeat control endoscopy after 7 days showed complete healing of the former ulcer site at the gastroesophageal junction. Although the incidence of post-transplantation Herpes simplex induced gastroesophageal disease is low, the viral HSV ulcer may be included into a differential diagnosis if dysphagia occurs after transplantation even if HSV-DNA PCR is negative.

  11. Pentyl Gallate Nanoemulsions as Potential Topical Treatment of Herpes Labialis.

    Science.gov (United States)

    Kelmann, Regina G; Colombo, Mariana; De Araújo Lopes, Sávia Caldeira; Nunes, Ricardo J; Pistore, Morgana; Dall Agnol, Daniele; Rigotto, Caroline; Silva, Izabella Thais; Roman, Silvane S; Teixeira, Helder F; Oliveira Simões, Cláudia M; Koester, Letícia S

    2016-07-01

    Previous studies have demonstrated the antiherpes activity of pentyl gallate (PG), suggesting that it could be a promising candidate for the topical treatment of human herpes labialis. PG low aqueous solubility represents a major drawback to its incorporation in topical dosage forms. Hence, the feasibility of incorporating PG into nanoemulsions, the ability to penetrate the skin, to inhibit herpes simplex virus (HSV)-1 replication, and to cause dermal sensitization or toxicity were evaluated. Oil/water nanoemulsions containing 0.5% PG were prepared by spontaneous emulsification. The in vitro PG distribution into porcine ear skin after topical application of nanoemulsions was assessed, and the in vitro antiviral activity against HSV-1 replication was evaluated. Acute dermal toxicity and risk of dermal sensitization were evaluated in rat model. Nanoemulsions presented nanometric particle size (from 124.8 to 143.7 nm), high zeta potential (from -50.1 to -66.1 mV), loading efficiency above 99%, and adequate stability during 12 months. All formulations presented anti-HSV-1 activity. PG was able to reach deeper into the dermis more efficiently from the nanoemulsion F4. This formulation as well as PG were considered safe for topical use. Nanoemulsions seem to be a safe and effective approach for topically delivering PG in the treatment of human herpes labialis infection.

  12. Rapid Detection of the Varicella Zoster Virus

    Science.gov (United States)

    Lewis, Michelle P.; Harding, Robert

    2011-01-01

    1.Technology Description-Researchers discovered that when the Varicella Zoster Virus (VZV) reactivates from latency in the body, the virus is consistently present in saliva before the appearance of skin lesions. A small saliva sample is mixed with a specialized reagent in a test kit. If the virus is present in the saliva sample, the mixture turns a red color. The sensitivity and specificity emanates from an antibody-antigen reaction. This technology is a rapid, non-invasive, point of-of-care testing kit for detecting the virus from a saliva sample. The device is easy to use and can be used in clinics and in remote locations to quickly detect VZV and begin treatment with antiviral drugs. 2.Market Opportunity- RST Bioscience will be the first and only company to market a rapid, same day test kit for the detection of VZV in saliva. The RST detection test kit will have several advantages over existing, competitive technology. The test kit is self contained and laboratory equipment is not required for analysis of the sample. Only a single saliva sample is required to be taken instead of blood or cerebral spinal fluid. The test kit is portable, sterile and disposable after use. RST detection test kits require no electrical power or expensive storage equipment and can be used in remote locations. 3.Market Analysis- According to the CDC, it is estimated that 1 million cases of shingles occur each year in the U.S. with more than half over the age of sixty. There is a high demand for rapid diagnostics by the public. The point-of-care testing (POCT) market is growing faster than other segments of in vitro diagnostics. According to a July 2007 InteLab Corporation industry report the overall market for POCT was forecast to increase from $10.3 billion in 2005 to $18.7 billion by 2011. The market value of this test kit has not been determined. 4.Competition- The VZV vaccine prevents 50% of cases and reduces neuralgia by 66%. The most popular test detects VZV-specific IgM antibody

  13. Herpes simplex virus infection during pregnancy.

    Science.gov (United States)

    Stephenson-Famy, Alyssa; Gardella, Carolyn

    2014-12-01

    Genital herpes in pregnancy continues to cause significant maternal morbidity, with an increasing number of infections being due to oral-labial transmission of herpes simplex virus (HSV)-1. Near delivery, primary infections with HSV-1 or HSV-2 carry the highest risk of neonatal herpes infection, which is a rare but potentially devastating disease for otherwise healthy newborns. Prevention efforts have been limited by lack of an effective intervention for preventing primary infections and the unclear role of routine serologic testing.

  14. Oral herpes simplex virus infection in pregnancy: what are the concerns?

    Science.gov (United States)

    Ficarra, Giuseppe; Birek, Catalena

    2009-09-01

    Although epidemiologic data and the potentially serious effects of transmission of genital herpes from mother to infant during birth have been widely reported, published reports on oral herpes disease in pregnancy remain scarce and no clear management guidelines exist. Thus, questions remain about acquisition, transmission and outcome of infection, especially with respect to acute gingivostomatitis in pregnancy. In response to these questions, we summarize previous reports on herpes simplex virus 1 (HSV-1) oral disease in pregnancy and, briefly, present 2 cases of primary gingivostomatitis in the first trimester of pregnancy, resulting in a favourable outcome for both mother and infant. We also point out the most recent data on rare, potentially severe in outcome, but treatable, primary central nervous system HSV-1 infection in later stages of pregnancy. Finally, we emphasize a multidisciplinary approach to oral HSV disease in pregnancy, with dentist participation in the diagnosis and treatment.

  15. Fulminant Staphylococcus lugdunensis septicaemia following a pelvic varicella-zoster virus infection in an immune-deficient patient: a case report

    Directory of Open Access Journals (Sweden)

    Woznowski M

    2010-09-01

    Full Text Available Abstract Introduction The deadly threat of systemic infections with coagulase negative Staphylococcus lugdunensis despite an appropriate antibiotic therapy has only recently been recognized. The predominant infectious focus observed so far is left-sided native heart valve endocarditis, but bone and soft tissue infections, septicaemia and vascular catheter-related bloodstream infections have also been reported. We present a patient with a fatal Staphylococcus lugdunensis septicaemia following zoster bacterial superinfection of the pelvic region. Case presentation A 71-year old male diagnosed with IgG kappa plasmocytoma presented with a conspicuous weight loss, a hypercalcaemic crisis and acute renal failure. After initiation of haemodialysis treatment his condition improved rapidly. However, he developed a varicella-zoster virus infection of the twelfth thoracic dermatome requiring intravenous acyclovir treatment. Four days later the patient presented with a fulminant septicaemia. Despite an early intravenous antibiotic therapy with ciprofloxacin, piperacillin/combactam and vancomycin the patient died within 48 hours, shortly before the infective isolate was identified as Staphylococcus lugdunensis by polymerase chain reaction. Conclusion Despite S. lugdunensis belonging to the family of coagulase-negative staphylococci with an usually low virulence, infections with S. lugdunensis may be associated with an aggressive course and high mortality. This is the first report on a Staphylococcus lugdunensis septicaemia following a zoster bacterial superinfection of the pelvic region.

  16. Varicella-zoster virus (VZV) mediates a delayed host shutoff independent of open reading frame (ORF) 17 expression.

    Science.gov (United States)

    Waterboer, Tim; Rahaus, Markus; Wolff, Manfred H

    2002-01-01

    Varicella-zoster virus (VZV) open reading frame 17 (ORF 17) is the gene corresponding to Herpes simplex-virus (HSV) UL41. The UL41 gene encodes the virion host shutoff factor (vhs), a RNase that has been the object of detailed studies. In contrast to HSV, knowledge about VZV mediated shutoff effects and the role of ORF 17 is poor. We investigated the ORF 17 expression in infected cells and analyzed shutoff effects. ORF 17 expression could not be proven in infected human fibroblast cell lines and melanoma (MeWo) cells. Only after induction by Phorbol 12-myristate 13-acetate an ORF 17 expression became detectable in MeWo cells. Nevertheless, using stable expressed GAPDH mRNA as a marker for mRNA degradation, a VZV mediated shutoff, independent of ORF 17 expression, became measurable. Transfection experiments demonstrated that transient ORF 17 expression did not decrease the cellular GAPDH mRNA level. We examined whether the VZV shutoff factor is a tegument protein causing an early shutoff or whether it needs to be expressed (delayed shutoff). The GAPDH mRNA level in Actinomycin D pretreated and infected MeWo cells did not decrease even faster than the theoretical decay rate based on a half-life of 24 h. These findings lead to the conclusion that the VZV shutoff factor is not a mature protein localized in the virion and that VZV causes a delayed virion host shutoff effect.

  17. A Study of Intravenous Administration of Vitamin C in the Treatment of Acute Herpetic Pain and Postherpetic Neuralgia

    Science.gov (United States)

    Kim, Min Sung; Kim, Dong Jin; Na, Chan Ho

    2016-01-01

    Background Although there are several available management strategies for treatment of both acute pain of herpes zoster (HZ) and postherpetic neuralgia (PHN), it is difficult to treat them adequately. Objective The aim of this study was to evaluate the efficacy of intravenously administrated vitamin C on acute pain and its preventive effects on PHN in patients with HZ. Methods Between September 2011 and May 2013 eighty-seven patients who were admitted for HZ were assessed according to age, sex, underlying diseases, duration of pain and skin lesion, dermatomal distribution, and PHN. It was a randomized controlled study, in which 87 patients were randomly allocated into the ascorbic acid group and control group. Each patient received normal saline infusion with or without 5 g of ascorbic acid on days 1, 3, and 5 then answered questionnaires that included side effects and pain severity using visual analogue scale on days 1, 2, 3, 4, and 5. After discharge, the severity of pain was obtained at out-patient clinic or by telephone on weeks 2, 4, 8, and 16. Results There was no differences in severity of pain on patients' age, sex, underlying diseases, duration of pain and skin lesion and dermatomal distribution between two groups (p>0.05). Since 8th week, pain score in ascorbic acid treatment group was significantly lower than control group (p <0.05). The incidence of PHN was significantly lower in the treatment group compared to control group (p=0.014). The changes of overall pain score was significantly different between the two groups (p<0.05). Conclusion Intravenously administered ascorbic acid did not relieve acute HZ pain; but is effective for reducing the incidence of PHN. PMID:27904265

  18. Varicella Zoster Virus Myelitis in Two Elderly Patients: Diagnostic Value of Nested Polymerase Chain Reaction Assay and Antibody Index for Cerebrospinal Fluid Specimens

    Directory of Open Access Journals (Sweden)

    Teruyuki Takahashi

    2013-04-01

    Full Text Available Background: Myelitis is one of the rarest neurological complications of the varicella zoster virus (VZV infection. Focal muscle weakness with or without sensory disturbance occurs in approximately 5% of the cases after acute VZV infection, with complete recovery in 50-70%. Case Presentation: This report describes two rare cases of elderly patients with VZV myelitis secondary to dermatomal zoster rash. Patient 1 was a 79-year-old woman who developed paraplegia, numbness and decreased sensation in the left arm and below thoracic (Th-10 after sacral zoster. Spinal cord MRI showed a high-signal-intensity lesion at the cervical spinal nerve 2 on a T2-weighted image. Patient 2 was a 73-year-old man who developed right flaccid leg weakness and urinary retention after right dorsal Th 5-8 zoster. Spinal cord MRI showed a high-signal-intensity lesion at Th 3-4 on a T2-weighted image. In both cases, although the conventional single polymerase chain reaction (PCR assays all showed negative results, the original nested PCR assay detected VZV DNA in the cerebrospinal fluid (CSF specimen collected on admission. In addition, the anti-VZV IgG antibody by enzyme immunoassay and antibody index were elevated in the CSF specimens during the clinical courses of both patients. On the basis of these findings, both patients were diagnosed with VZV myelitis and were treated with high-dose acyclovir and corticosteroid. This combined treatment was appropriate and effective for the improvement of their functional outcomes. Conclusion: The detection of VZV DNA in CSF by nested PCR assay and the evaluation of the antibody index to VZV had significant diagnostic value.

  19. Evolução branda de recidiva de infecção por varicela zoster após tratamento com fingolimode em paciente com esclerose múltipla: relato de casoBenign evolution of shingles with fingolimod in a patient with multiple sclerosis: case report

    Directory of Open Access Journals (Sweden)

    Antonio Arlindo Morais

    2016-03-01

    Full Text Available Objetivo: Relatar o caso de um paciente com recidiva de herpes-zoster (HZ e evolução benigna mesmo diante de imunomodulação para esclerose múltipla (EM. Descrição de caso: Mulher de 48 anos com história de EM durante seis anos, previamente tratada com interferon1b, iniciou tratamento com fingolimode, desenvolvendo HZ após 10 meses de tratamento. Mesmo sem tratamento com acyclovir, a paciente desenvolveu um curso brando, sem posterior desenvolvimento de neuralgia pós-herpética. Conclusões: As novas terapias para EM podem estar associadas a novos tipos de eventos adversos. Apesar da potencial gravidade, nem todos os pacientes com HZ em uso das novas terapias para EM têm curso desfavorável, sendo necessários estudos para identificar fatores de risco para as formas graves.

  20. Neonatal herpes in Denmark 1977-1991

    DEFF Research Database (Denmark)

    1997-01-01

    BACKGROUND: To prevent neonatal herpes, women in labor with genital herpes infection are still delivered by Cesarean section. This policy is currently being debated. The aim of this study was to determine the incidence of neonatal herpes in Denmark and to evaluate the prevention practice. METHODS......: All newborns with perinatal herpes in Denmark 1977-1991 were identified from hospital-records. RESULTS: Of 862,298 deliveries 136 possible cases were found but only 30 (22%) fulfilled the criteria for neonatal herpes. The incidence increased from 2.36 to 4.56 per 100,000 live births during 1977......%) did not have any sequelae. Four (13%) died. Six (20%) had serious neurological sequelae. Seven (23%) only had cutaneous recurrences. In seven cases (23%) information was insufficient. CONCLUSIONS: During a 15 year period in Denmark only one neonate had serious sequelae following a recognized maternal...

  1. Herpes Simplex Viruses and Induction of Interferon Responses

    Institute of Scientific and Technical Information of China (English)

    Yijie Ma; Dustin Vepooten; Bin He

    2008-01-01

    Herpes simplex viruses (HSV) are human pathogens responsible for a variety of diseases,including localized mucocutaneous lesions,encephalitis,and disseminated diseases.HSV infection leads to rapid induction of innate immune responses.A critical part of this host response is the type I IFN system including the induction of type I IFNs,IFN-mediated signaling and amplification of IFN response.This provides the host with immediate countermeasure during acute infection to limit initial viral replication and to facilitate an appropriate adaptive immune response.However,HSV has devised multiple strategies to evade and interfere with innate immunity.This review will focus on the induction of type I IFN response by HSV during acute infection and current knowledge of mechanisms by which HSV interferes with this induction process.

  2. Unusual presentation of herpes simplex virus infection in a boxer: 'Boxing glove herpes'.

    Science.gov (United States)

    García-García, Begoña; Galache-Osuna, Cristina; Coto-Segura, Pablo; Suárez-Casado, Héctor; Mallo-García, Susana; Jiménez, Jorge Santos-Juanes

    2013-02-01

    Herein, we describe a patient with lesions of cutaneous herpes simplex virus 1 (HSV-1) infection over the knuckles of both hands in the context of an outbreak among boxers. Interestingly, the infection had an unusually long duration (4 weeks), and was not acquired directly through skin-to-skin contact, as it usually does among athletes (herpes gladiatorum). In our case, transmission was acquired through the use of shared boxing gloves contaminated by HSV-1. To the best of our knowledge, herpes gladiatorum, or wrestler's herpes, has not been described previously in boxers and infection over the knuckles is not commonly reported.

  3. Acute myopericarditis masquerading as acute myocardial infarction

    Institute of Scientific and Technical Information of China (English)

    Wen Tian; Zixin Zhang; Xiaojuan Bai; Dingyin Zeng; Guoxian Qi

    2008-01-01

    Patients with abrupt onset of chest pain, ischemic ECG abnormalities and elevated levels of cardiac markers could be given a diagnosis of acute myocardial infarction. However, some other diseases should be taken into consideration in this clinical setting when coronary arteries are proven to be normal. Here we report a case of acute myopericarditis with clinical presentation of myocardial infarction and normal coronary anatomy. The Herpes Simplex Virus Ⅱ was considered as the organism causing myopericarditis and the patient was recovered by the treatment with valacicloavir. A precise diagnosis is a prerequisite of successful treatment and favorable prognosis.

  4. Optic neuritis following Varicella zoster vaccination: report of two cases.

    Science.gov (United States)

    Han, Sang Beom; Hwang, Jeong-Min; Kim, Ji-Soo; Yang, Hee Kyung

    2014-09-03

    Two women presented at our clinic with vision blurring following Varicella zoster virus (VZV) vaccination, 3 weeks and 1 week ago. Ophthalmologic examination and magnetic resonance imaging revealed bilateral and unilateral optic neuritis, respectively. One patient had a history of optic neuritis in the fellow eye 33 years ago without recurrence since then. Both patients completely recovered after treatment with high dose intravenous methylprednisolone followed by a tapered dose of oral prednisolone. This is the first report of optic neuritis occurring in relation to VZV vaccination.

  5. Metabolic processes in limfocytes of pathients with varicella zoster infections

    Directory of Open Access Journals (Sweden)

    Yu. S. Tichonova

    2012-01-01

    Full Text Available Measurement of metabolic processes in lymphocytes in Varicella zoster infection showed highly increased intercellular glycolisys activity with functional cellular overload. Same time, we discovered decreased level of intensivity of first stages of TCC, that rules to lower cycle energetic efficiency and intense metabolitsaminoacides intake for TCC, guiding to high aminoacides transport to lymphocytes. Usage of succinic acid and its salts gives more substrates for TCC, increasing its energetic efficiency and lymphocytes functional activity.

  6. Metabolic processes in limfocytes of pathients with varicella zoster infections

    OpenAIRE

    Yu. S. Tichonova; G. V. Bulygin; T. Yu. Kuzmina; E. P. Tichonova

    2012-01-01

    Measurement of metabolic processes in lymphocytes in Varicella zoster infection showed highly increased intercellular glycolisys activity with functional cellular overload. Same time, we discovered decreased level of intensivity of first stages of TCC, that rules to lower cycle energetic efficiency and intense metabolitsaminoacides intake for TCC, guiding to high aminoacides transport to lymphocytes. Usage of succinic acid and its salts gives more substrates for TCC, increasing its energetic ...

  7. Subclinical Shed of Infectious Varicella zoster Virus in Astronauts

    Science.gov (United States)

    Cohrs, Randall J.; Mehta, Satish K.; Schmid, D. Scott; Gilden, Donald H.; Pierson, Duane L.

    2007-01-01

    Aerosol borne varicella zoster virus (VZV) enters the nasopharynx and replicates in tonsillar T-cells, resulting in viremia and varicella (chickenpox). Virus then becomes latent in cranial nerve, dorsal root and autonomic nervous system ganglia along the entire neuraxis (1). Decades later, as cell-mediated immunity to VZV declines (4), latent VZV can reactivate to produce zoster (shingles). Infectious VZV is present in patients with varicella or zoster, but shed of infectious virus in the absence of disease has not been shown. We previously detected VZV DNA in saliva of astronauts during and shortly after spaceflight, suggesting stress induced subclinical virus reactivation (3). We show here that VZV DNA as well as infectious virus in present in astronaut saliva. VZV DNA was detected in saliva during and after a 13-day spaceflight in 2 of 3 astronauts (Fig. panel A). Ten days before liftoff, there was a rise in serum anti-VZV antibody in subjects 1 and 2, consistent with virus reactivation. In subject 3, VZV DNA was not detected in saliva, and there was no rise in anti-VZV antibody titer. Subject 3 may have been protected from virus reactivation by having zoster boost in cell-medicated immunity to VZV (2). No VZV DNA was detected in astronaut saliva months before spaceflight, or in saliva of 10 age/sex-matched healthy control subjects sampled on alternate days for 3 weeks (88 saliva samples). Saliva taken 2-6 days after landing from all 3 subjects was cultured on human fetal lung cells (Fig. panel B). Infectious VZV was recovered from saliva of subjects 1 and 2 on the second day after landing. Virus specificity was confirmed by antibody staining and DNA analysis which showed it to be VZV of European descent, common in the US (5). Further, both antibody staining and DNA PCR demonstrated that no HSV-1 was detected in any infected culture. This is the first report of infectious VZV shedding in the absence of clinical disease. Spaceflight presents a uniquely stressful

  8. Varicella-zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line.

    Directory of Open Access Journals (Sweden)

    Peter G E Kennedy

    Full Text Available Post-herpetic neuralgia (PHN is the most significant complication of herpes zoster caused by reactivation of latent Varicella-Zoster virus (VZV. We undertook a heterologous infection in vitro study to determine whether PHN-associated VZV isolates induce changes in sodium ion channel currents known to be associated with neuropathic pain. Twenty VZV isolates were studied blind from 11 PHN and 9 non-PHN subjects. Viruses were propagated in the MeWo cell line from which cell-free virus was harvested and applied to the ND7/23-Nav1.8 rat DRG x mouse neuroblastoma hybrid cell line which showed constitutive expression of the exogenous Nav 1.8, and endogenous expression of Nav 1.6 and Nav 1.7 genes all encoding sodium ion channels the dysregulation of which is associated with a range of neuropathic pain syndromes. After 72 hrs all three classes of VZV gene transcripts were detected in the absence of infectious virus. Single cell sodium ion channel recording was performed after 72 hr by voltage-clamping. PHN-associated VZV significantly increased sodium current amplitude in the cell line when compared with non-PHN VZV, wild-type (Dumas or vaccine VZV strains ((POka, Merck and GSK. These sodium current increases were unaffected by acyclovir pre-treatment but were abolished by exposure to Tetrodotoxin (TTX which blocks the TTX-sensitive fast Nav 1.6 and Nav 1.7 channels but not the TTX-resistant slow Nav 1.8 channel. PHN-associated VZV sodium current increases were therefore mediated in part by the Nav 1.6 and Nav 1.7 sodium ion channels. An additional observation was a modest increase in message levels of both Nav1.6 and Nav1.7 mRNA but not Nav 1.8 in PHN virally infected cells.

  9. Varicella-zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line.

    Science.gov (United States)

    Kennedy, Peter G E; Montague, Paul; Scott, Fiona; Grinfeld, Esther; Ashrafi, G H; Breuer, Judith; Rowan, Edward G

    2013-01-01

    Post-herpetic neuralgia (PHN) is the most significant complication of herpes zoster caused by reactivation of latent Varicella-Zoster virus (VZV). We undertook a heterologous infection in vitro study to determine whether PHN-associated VZV isolates induce changes in sodium ion channel currents known to be associated with neuropathic pain. Twenty VZV isolates were studied blind from 11 PHN and 9 non-PHN subjects. Viruses were propagated in the MeWo cell line from which cell-free virus was harvested and applied to the ND7/23-Nav1.8 rat DRG x mouse neuroblastoma hybrid cell line which showed constitutive expression of the exogenous Nav 1.8, and endogenous expression of Nav 1.6 and Nav 1.7 genes all encoding sodium ion channels the dysregulation of which is associated with a range of neuropathic pain syndromes. After 72 hrs all three classes of VZV gene transcripts were detected in the absence of infectious virus. Single cell sodium ion channel recording was performed after 72 hr by voltage-clamping. PHN-associated VZV significantly increased sodium current amplitude in the cell line when compared with non-PHN VZV, wild-type (Dumas) or vaccine VZV strains ((POka, Merck and GSK). These sodium current increases were unaffected by acyclovir pre-treatment but were abolished by exposure to Tetrodotoxin (TTX) which blocks the TTX-sensitive fast Nav 1.6 and Nav 1.7 channels but not the TTX-resistant slow Nav 1.8 channel. PHN-associated VZV sodium current increases were therefore mediated in part by the Nav 1.6 and Nav 1.7 sodium ion channels. An additional observation was a modest increase in message levels of both Nav1.6 and Nav1.7 mRNA but not Nav 1.8 in PHN virally infected cells.

  10. Exocytosis of Varicella-Zoster Virus Virions Involves a Convergence of Endosomal and Autophagy Pathways

    Science.gov (United States)

    Buckingham, Erin M.; Jarosinski, Keith W.; Jackson, Wallen; Carpenter, John E.

    2016-01-01

    ABSTRACT Varicella-zoster virus (VZV) is an extremely cell-associated herpesvirus with limited egress of viral particles. The induction of autophagy in VZV-infected monolayers is easily detectable; inhibition of autophagy leads to decreased VZV glycoprotein biosynthesis and diminished viral titers. To explain how autophagic flux could exert a proviral effect on the VZV infectious cycle, we postulated that the VZV exocytosis pathway following secondary envelopment may converge with the autophagy pathway. This hypothesis depended on known similarities between VZV gE and autophagy-related (Atg) Atg9/Atg16L1 trafficking pathways. Investigations were carried out with highly purified fractions of VZV virions. When the virion fraction was tested for the presence of autophagy and endosomal proteins, microtubule-associated protein 1 light chain (MAP1LC3B) and Ras-like GTPase 11 (Rab11) were detected. By two-dimensional (2D) and 3D imaging after immunolabeling, both proteins also colocalized with VZV gE in a proportion of cytoplasmic vesicles. When purified VZV virions were enumerated after immunoelectron microscopy, gold beads were detected on viruses following incubation with antibodies to VZV gE (∼100%), Rab11 (50%), and LC3B (30%). Examination of numerous electron micrographs demonstrated that enveloped virions were housed in single-membraned vesicles; viral particles were not observed in autophagosomes. Taken together, our data suggested that some viral particles after secondary envelopment accumulated in a heterogeneous population of single-membraned vesicular compartments, which were decorated with components from both the endocytic pathway (Rab11) and the autophagy pathway (LC3B). The latter cytoplasmic viral vesicles resembled an amphisome. IMPORTANCE VZV infection leads to increased autophagic flux, while inhibition of autophagy leads to a marked reduction in virus spread. In this investigation of the proviral role of autophagy, we found evidence for an

  11. Variation in the WBC differential count and other factors associated with reporting of herpes labialis: a population-based study of adults.

    Science.gov (United States)

    Parks, Christine G; Andrew, Michael E; Blanciforti, Laura A; Luster, Michael I

    2007-11-01

    Reactivation of latent herpes virus has been linked to triggers of mild immunosupression, such as stress or UV-exposure. Despite having predictive value in severe immunodeficiency, the white blood cell (WBC) differential count has not been examined in relation to risk of herpes reactivation in population studies. The WBC differential count and other risk factors for herpes labialis were examined in 5687 adults (ages 18-64) from the Third National Health and Nutrition Examination Survey, who had WBC 3.5-11 x 10(6) cells mL(-1) and reported no acute infections in the past month. The association between self-reported herpes labialis in the past year and the WBC differential count was modeled, adjusting for age, sex, race/ethnicity, education, smoking, upper respiratory infections (URI), and HSV-1 antibodies. Herpes labialis was significantly associated with white race/ethnicity, being a nonsmoker, and frequent URI. Compared with the highest quartile, being in the lowest quartile of granulocytes was associated with herpes labialis, adjusted odds ratio=1.82 (95% confidence interval 1.20, 2.28). At the same time, there was a trend towards an inverse association of lower lymphocyte count and herpes labialis. These findings suggest that moderate differences in the WBC differential count are related to reactivation of HSV-1. Prospective studies may help to show whether such differences indicate susceptibility to loss of latency or represent a consequence of reactivated infection.

  12. Therapeutic options for herpes labialis: experimental and natural therapies.

    Science.gov (United States)

    Elish, Diana; Singh, Fiza; Weinberg, Jeffrey M

    2005-07-01

    Herpes labialis, a common condition characterized by recurrent vesicular eruptions primarily on the lips and perioral skin, causes pain and discomfort for millions of adults each year. Over the past several years, the major focus of herpes research has been on the treatment of genital herpes. However, several studies have been conducted to evaluate the efficacy of therapies specifically for herpes labialis. Last year in Cutis, we reviewed oral and topical therapies for herpes labialis. In this final part of the series, we review experimental and natural treatments that are available for herpes labialis and its associated symptoms.

  13. Herpes simplex virus 1 pneumonia: conventional chest radiograph pattern

    Energy Technology Data Exchange (ETDEWEB)

    Umans, U.; Golding, R.P.; Duraku, S.; Manoliu, R.A. [Dept. of Radiology, Academic Hospital ' ' Vrije Universiteit' ' , Amsterdam (Netherlands)

    2001-06-01

    The aim of this study was to describe the findings on plain chest radiographs in patients with herpes simplex virus pneumonia (HSVP). The study was based on 17 patients who at a retrospective search have been found to have a monoinfection with herpes simplex virus. The diagnosis was established by isolation of the virus from material obtained during fiberoptic bronchoscopy (FOB) which also included broncho-alveolar lavage and tissue sampling. Fourteen patients had a chest radiograph performed within 24 h of the date of the FOB. Two radiographs showed no abnormalities of the lung parenchyma. The radiographs of the other 12 patients showed lung opacification, predominantly lobar or more extensive and always bilateral. Most patients presented with a mixed airspace and interstitial pattern of opacities, but 11 of 14 showed at least an airspace consolidation. Lobar, segmental, or subsegmental atelectasis was present in 7 patients, and unilateral or bilateral pleural effusion in 8 patients, but only in 1 patient was it a large amount. In contradiction to the literature which reports a high correlation between HSVP and acute respiratory distress syndrome (ARDS), 11 of 14 patients did not meet the pathophysiological criteria for ARDS. The radiologist may suggest the diagnosis of HSVP when bilateral airspace consolidation or mixed opacities appear in a susceptible group of patients who are not thought to have ARDS or pulmonary edema. The definite diagnosis of HSV pneumonia can be established only on the basis of culture of material obtained by broncho-alveolar lavage. (orig.)

  14. The epidemiology of Varicella Zoster Virus infection in Italy

    Directory of Open Access Journals (Sweden)

    Ciofi degli Atti Marta L

    2008-10-01

    Full Text Available Abstract Background The epidemiological importance of varicella and zoster and the availability of an efficacious and safe vaccine have led to an important international debate regarding the suitability of mass vaccination. The objective of the study was to describe the epidemiology of varicella and zoster in Italy and to determine whether there have been changes with respect to observations provided by an analogous study conducted 8 years ago, in order to define the most appropriate vaccination strategy. Methods A number of data sources were evaluated, a cross-sectional population-based seroprevalence study was conducted on samples collected in 2004, and the results were compared with data obtained in 1996. Results The data from active and passive surveillance systems confirm that varicella is a widespread infectious disease which mainly affects children. VZV seroprevalence did not substantially differ from that found in the previous study. The sero-epidemiological profile in Italy is different from that in other European countries. In particular, the percentage of susceptible adolescents is at least nearly twice as high as in other European countries and in the age group 20–39 yrs, approximately 9% of individuals are susceptible to VZV. Conclusion The results of this study can contribute to evaluating the options for varicella vaccination. It is possible that in a few years, in all Italian Regions, there will exist the conditions necessary for implementing a mass vaccination campaign and that the large-scale availability of MMRV tetravalent vaccines will facilitate mass vaccination.

  15. Varicella Zoster Virus (VZV-Human Neuron Interaction

    Directory of Open Access Journals (Sweden)

    Don Gilden

    2013-09-01

    Full Text Available Varicella zoster virus (VZV is a highly neurotropic, exclusively human herpesvirus. Primary infection causes varicella (chickenpox, wherein VZV replicates in multiple organs, particularly the skin. Widespread infection in vivo is confirmed by the ability of VZV to kill tissue culture cells in vitro derived from any organ. After varicella, VZV becomes latent in ganglionic neurons along the entire neuraxis. During latency, virus DNA replication stops, transcription is restricted, and no progeny virions are produced, indicating a unique virus-cell (neuron relationship. VZV reactivation produces zoster (shingles, often complicated by serious neurological and ocular disorders. The molecular trigger(s for reactivation, and thus the identity of a potential target to prevent it, remains unknown due to an incomplete understanding of the VZV-neuron interaction. While no in vitro system has yet recapitulated the findings in latently infected ganglia, recent studies show that VZV infection of human neurons in SCID mice and of human stem cells, including induced human pluripotent stem cells and normal human neural progenitor tissue-like assemblies, can be established in the absence of a cytopathic effect. Usefulness of these systems in discovering the mechanisms underlying reactivation awaits analyses of VZV-infected, highly pure (>90%, terminally differentiated human neurons capable of prolonged survival in vitro.

  16. Disseminated Neonatal Herpes Caused by Herpes Simplex Virus Types 1 and 2

    Science.gov (United States)

    Martic, Jelena; Stanojevic, Maja; Jankovic, Sasa; Nedeljkovic, Jasminka; Nikolic, Ljubica; Pasic, Srdjan; Jankovic, Borisav; Jovanovic, Tanja

    2007-01-01

    Disseminated neonatal herpes simplex virus (HSV) infection is characterized by progressive multiple organ failure and high mortality rates. It can result from infection with either HSV-1 or HSV-2. We report a case of disseminated neonatal herpes that was caused by HSV-1 and HSV-2. PMID:17479897

  17. Herpes

    Science.gov (United States)

    ... in HIV-infected individuals; up to 90% of HIV-infected individuals are co-infected with HSV-2. ^ Back to top Proudly sponsored by ... Learn more about ... Understanding Your Tests Inside the Lab In the News Article Index About This Site Send Us Your Comments ...

  18. Docosanol: new drug. Herpes labialis: barely more effective than an excipient.

    Science.gov (United States)

    2009-06-01

    (1) Herpes is a contagious, recurrent viral infection of the skin and mucous membranes. In immunocompetent patients the recurrences can be troublesome but they heal spontaneously. Management is mainly based on lifestyle measures. Local application of an antiviral drug such as aciclovir has modest effects. It reduces healing time by about 2 days provided treatment is started as soon as the first symptoms appear; (2) Docosanol, a fatty alcohol, was recently authorized in France for treatment of episodes of herpes labialis; (3) A trial in 474 patients showed no tangible difference between docosanol and 5% aciclovir in reducing healing time; (4) Clinical evaluation also includes two trials versus an excipient (polyethylene glycol) including 370 and 373 patients. The median healing time was reduced by less than a day; (5) In these trials, the adverse effects of docosanol were similar to those of the excipients. In particular, docosanol cream contains excipients that can provoke allergic reactions; (6) In practice, docosanol cream is barely or no more effective than an excipient in treating acute episodes of herpes labialis. Lifestyle measures are still the cornerstone of herpes management.

  19. Effect of ASP2151, a herpesvirus helicase-primase inhibitor, in a guinea pig model of genital herpes.

    Science.gov (United States)

    Katsumata, Kiyomitsu; Chono, Koji; Sudo, Kenji; Shimizu, Yasuaki; Kontani, Toru; Suzuki, Hiroshi

    2011-08-25

    ASP2151 is a herpesvirus helicase-primase inhibitor with antiviral activity against varicella zoster virus and herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). Here, we examined the potency and efficacy of ASP2151 against HSV in vitro and in vivo. We found that ASP2151 was more potent in inhibiting the replication of HSV-1 and HSV-2 in Vero cells in the plaque reduction assay and had greater anti-HSV activity in a guinea pig model of genital herpes than did acyclovir and valacyclovir (VACV), respectively. Oral ASP2151 given from the day of infection reduced peak and overall disease scores in a dose-dependent manner, resulting in complete prevention of symptoms at the dose of 30 mg/kg. The 50% effective dose (ED(50)) values for ASP2151 and VACV were 0.37 and 68 mg/kg, respectively, indicating that ASP2151 was 184-fold more potent than VACV. When ASP2151 was administered after the onset of symptoms, the disease course of genital herpes was suppressed more effectively than by VACV, with a significant reduction in disease score observed one day after starting ASP2151 at 30 mg/kg, whereas the therapeutic effect of VACV was only evident three days after treatment at the highest dose tested (300 mg/kg). This indicated that ASP2151 possesses a faster onset of action and wider therapeutic time window than VACV. Further, virus shedding from the genital mucosa was significantly reduced with ASP2151 at 10 and 30 mg/kg but not with VACV, even at 300 mg/kg. Taken together, our present findings demonstrated the superior potency and efficacy of ASP2151 against HSV.

  20. Effect of ASP2151, a Herpesvirus Helicase-Primase Inhibitor, in a Guinea Pig Model of Genital Herpes

    Directory of Open Access Journals (Sweden)

    Toru Kontani

    2011-08-01

    Full Text Available ASP2151 is a herpesvirus helicase-primase inhibitor with antiviral activity against varicella zoster virus and herpes simplex virus types 1 (HSV-1 and 2 (HSV-2. Here, we examined the potency and efficacy of ASP2151 against HSV in vitro and in vivo. We found that ASP2151 was more potent in inhibiting the replication of HSV-1 and HSV-2 in Vero cells in the plaque reduction assay and had greater anti-HSV activity in a guinea pig model of genital herpes than did acyclovir and valacyclovir (VACV, respectively. Oral ASP2151 given from the day of infection reduced peak and overall disease scores in a dose-dependent manner, resulting in complete prevention of symptoms at the dose of 30 mg/kg. The 50% effective dose (ED50 values for ASP2151 and VACV were 0.37 and 68 mg/kg, respectively, indicating that ASP2151 was 184-fold more potent than VACV. When ASP2151 was administered after the onset of symptoms, the disease course of genital herpes was suppressed more effectively than by VACV, with a significant reduction in disease score observed one day after starting ASP2151 at 30 mg/kg, whereas the therapeutic effect of VACV was only evident three days after treatment at the highest dose tested (300 mg/kg. This indicated that ASP2151 possesses a faster onset of action and wider therapeutic time window than VACV. Further, virus shedding from the genital mucosa was significantly reduced with ASP2151 at 10 and 30 mg/kg but not with VACV, even at 300 mg/kg. Taken together, our present findings demonstrated the superior potency and efficacy of ASP2151 against HSV.