WorldWideScience

Sample records for activity programme kiss

  1. Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54.

    Science.gov (United States)

    Navarro, V M; Castellano, J M; Fernández-Fernández, R; Tovar, S; Roa, J; Mayen, A; Nogueiras, R; Vazquez, M J; Barreiro, M L; Magni, P; Aguilar, E; Dieguez, C; Pinilla, L; Tena-Sempere, M

    2005-01-01

    Loss-of-function mutations of the gene encoding GPR54, the putative receptor for the KiSS-1-derived peptide metastin, have been recently associated with hypogonadotropic hypogonadism, in both rodents and humans. Yet the actual role of the KiSS-1/GPR54 system in the neuroendocrine control of gonadotropin secretion remains largely unexplored. To initiate such analysis, the effects of KiSS-1 peptide on LH secretion were monitored using in vivo and in vitro settings under different experimental conditions. Central intracerebroventricular administration of KiSS-1 peptide potently elicited LH secretion in vivo over a range of doses from 10 pmol to 1 nmol. The effect of centrally injected KiSS-1 appeared to be mediated via the hypothalamic LHRH. However, no effect of central administration of KiSS-1 was detected on relative LHRH mRNA levels. Likewise, systemic (i.p. and i.v.) injection of KiSS-1 markedly stimulated LH secretion. This effect was similar in terms of maximum response to that of central administration of KiSS-1 and might be partially attributed to its ability to stimulate LH secretion directly at the pituitary. Finally, the LH-releasing activity of KiSS-1 was persistently observed after blockade of endogenous excitatory amino acid and nitric oxide pathways, i.e. relevant neurotransmitters in the neuroendocrine control of LH secretion. In summary, our results provide solid evidence for a potent stimulatory effect of KiSS-1 on LH release, acting at central levels (likely the hypothalamus) and eventually at the pituitary, and further document a novel role of the KiSS-1/GPR54 system as a relevant downstream element in the neuroendocrine network governing LH secretion. PMID:15375028

  2. Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54.

    Science.gov (United States)

    Navarro, V M; Fernández-Fernández, R; Castellano, J M; Roa, J; Mayen, A; Barreiro, M L; Gaytan, F; Aguilar, E; Pinilla, L; Dieguez, C; Tena-Sempere, M

    2004-12-01

    The awakening of the gonadotrophic axis at puberty is the end-point of a complex cascade of sex developmental events that leads to the attainment of reproductive capacity. Recently, loss-of-function mutations of the gene encoding GPR54, the putative receptor for the KiSS-1-derived peptide metastin, have been linked to hypogonadotrophic hypogonadism, both in rodents and humans. However, the actual role of the KiSS-1/GPR54 system in the timing of puberty onset remains unexplored. We report herein that chronic central administration of KiSS-1 peptide to immature female rats induced the precocious activation of the gonadotrophic axis, as estimated by advanced vaginal opening, elevated uterus weight, and increased serum levels of luteinizing hormone (LH) and oestrogen. The central effect of KiSS-1 upon LH release appeared to be mediated via the hypothalamic LH-releasing hormone. In contrast, despite the well-documented permissive role of body fat stores and the adipocyte-derived hormone leptin in puberty maturation, acute activation of the gonadotrophic axis by KiSS-1 was persistently observed in pubertal animals under food deprivation, after central immunoneutralization of leptin, and in a model of leptin resistance. Overall, the present results, together with our recent data on maximum expression of KiSS-1 and GPR54 genes in the hypothalamus at puberty, provide novel evidence for a role of the KiSS-1 system as a downstream element in the hypothalamic network triggering the onset of puberty. PMID:15486019

  3. The forebrain-midbrain acts as functional endocrine signaling pathway of Kiss2/Gnrh1 system controlling the gonadotroph activity in the teleost fish European sea bass (Dicentrarchus labrax).

    Science.gov (United States)

    Espigares, Felipe; Carrillo, Manuel; Gómez, Ana; Zanuy, Silvia

    2015-03-01

    Some teleost species, including European sea bass, harbor two different kisspeptin coding genes: kiss1 and kiss2. Both genes are expressed in the brain, but their differential roles in the central control of fish reproduction are only beginning to be elucidated. In this study, we have examined the effects of intracerebroventricular injections of the highly active sea bass peptides Kiss1-15 and Kiss2-12 on spermiating male sea bass. Physiological saline, Kiss1-15, or Kiss2-12 was injected into the third ventricle. To establish the gene expression cascade involved in the action of kisspeptins, the expression of the two sea bass kisspeptin receptor genes (kiss1r and kiss2r) and the three sea bass Gnrh genes (gnrh1, gnrh2, and gnrh3) were analyzed in the forebrain-midbrain and the hypothalamus. In addition, the protein levels of hypothalamic and pituitary Gnrh1 were measured. Blood samples were collected at different times after injection to analyze the effects of kisspeptins on the release of gonadotropins (Lh and Fsh) and androgens (testosterone and 11-ketotestosterone). The present results provide the first evidence that the effects of Kiss2 on central regulation of reproductive function involve the neuroendocrine areas of the forebrain-midbrain in teleost fish. The marked effect of Kiss2 on kiss2r and gnrh1 expression in the forebrain-midbrain and on Gnrh1 release suggest that this neuronal system is involved in the neuroendocrine regulation of gonadotroph activity. This hypothesis was confirmed by a surge of plasma Lh in response to Kiss2, which presumably has a strong stimulatory effect on testosterone release, and thus on sperm quality parameters.

  4. Distance Geometry for Kissing Balls

    CERN Document Server

    Chen, Hao

    2012-01-01

    A kissing ball is a ball that is tangent to a fixed reference ball. In this paper, we will treat kissing balls with techniques from the Euclidean distance geometry. This turns out to be more general than the classical Euclidean distance geometry. We will show that the distance matrix for the kissing balls plays, at the same time, the role of Cayley-Menger matrix. Thus classical problems in Euclidean distance geometry will have new versions for kissing balls.

  5. Haploinsufficiency in the prometastasis Kiss1 Receptor Gpr54 delays breast tumor initiation, progression and lung metastasis

    Science.gov (United States)

    Cho, Sung-Gook; Wang, Ying; Rodriguez, Melissa; Tan, Kunrong; Zhang, Wenzheng; Luo, Jian; Li, Dali; Liu, Mingyao

    2016-01-01

    Activation of KISS1 receptor (KISS1R or GPR54) by its ligands (kisspeptins) regulates a diverse function both in normal physiology and pathophysiology. In cancer, KISS1-induced KISS1R signaling is known to inhibit tumor angiogenesis and metastasis. However, roles of KISS1 and KISS1R in earlier stages of tumor progression and metastasis in vivo are still unknown. In this study, we demonstrate a critical role for Kiss1r in early stages of tumor progression using mouse tumor models. PyMT/Kiss1r mice with different Kiss1r genotypes were obtained by crossing MMTV-PyMT transgenic mouse with Kiss1r heterozygous mouse (Kiss1r+/−). Kiss1r heterozygosity attenuated breast tumor initiation, growth, latency, multiplicity and metastasis in MMTV-PyMT/Kiss1r+/− mouse models. To confirm the effects of Kiss1r in tumor progression and limit any effect of endogenous hormones, we isolated primary tumor cells from PyMT/Kiss1r+/+ or PyMT/Kiss1r+/− mice and performed in vitro and in vivo tumorigenesis assays. Kiss1r heterozygosity inhibited PyMT-induced in vitro tumorigeneity and in vivo tumor growth in NOD.SCID/NCr mice. To understand the underlying mechanism, we showed that activation of KISS1R by kisspeptin-10 led to RhoA activation and RhoA-dependent gene expression through Gαq-p63RhoGEF signaling pathway. Furthermore, anchorage-independent growth was tightly linked to the dosage-dependent regulation of RhoA by KISS1R. When MCF10A cells overexpressing H-RasV12 were subjected to in vitro tumorigenesis assays, knockdown of KISS1R or inactivation of RhoA in MCF10A cells reduced Ras-induced anchorage-independent growth, similar to our data obtained from PyMT-Kiss1r+/− mouse models. Altogether, we conclude that Kiss1r haploinsufficiency delays breast tumor initiation, progression and metastasis through its downstream Gαq-p63RhoGEF-RhoA signaling pathway. PMID:21852382

  6. Inspection of licensee - Maintenance programme and activities

    International Nuclear Information System (INIS)

    An effective maintenance programme is critical to sustained safe and reliable operation of nuclear power plants. The Working Group on Inspection Practices (WGIP) concluded that when a licensee has an effective maintenance programme, the overall operating safety of the plant is improved and the protection of public health and safety enhanced. All Regulatory Bodies (RB) consider maintenance to be an important area for oversight. Although a variety of inspection practices are being used; RB are actively monitoring licensee performance. Specifically the following conclusions were reached and commendable practices identified: - Maintenance oversight by regulators appears to be in a stable continuous improvement state. Most regulators are executing inspection oversight based on an existing regulatory framework. - The performance of a licensee's maintenance programme is recognized as important part of maintaining nuclear safety. The result of the maintenance program assessment is included in the overall performance assessment of a license. - Maintenance inspection activities are recognized as an important part of the regulatory oversight process. Inspection activities are based on the safety significance and nature of work being performed by the licensee. - The effectiveness of the maintenance inspection activities is recognized to rely on properly qualified inspectors; who are adequately supported by specialists. Training and qualification of inspectors should be based on how the RB reviews and inspects licensee maintenance programmes. - Reporting requirements are identified to provide information on the licensees maintenance programme, and to help guide inspection activities. - Performance Indicators are recognized as a useful tool for helping focus regulatory activities. Basic PI are identified and tracked by the RB, and use of PI by the licensee is monitored. - Inspections are designed to confirm that the licensee is planning and scheduling maintenance with due

  7. Microarray of programmable electrochemically active elements

    DEFF Research Database (Denmark)

    S. McCaskill, John; Maeke, Thomas; Straczek, Lukas;

    2016-01-01

    This paper describes possible applications of a two dimensional array of programmable electrochemically active elements to Alife. The array has been developed as part of the MICREA-gents project, and after several design phases, is now a mature enough device for general use beyond the project. Here...

  8. Developmental Profile and Sexually Dimorphic Expression of Kiss1 and Kiss1r in the Fetal Mouse Brain

    Directory of Open Access Journals (Sweden)

    John Gabriel Knoll

    2013-10-01

    Full Text Available The hypothalamic-pituitary-gonadal axis (HPG is a complex neuroendocrine circuit involving multiple levels of regulation. Kisspeptin neurons play essential roles in controlling the HPG axis from the perspectives of puberty onset, oscillations of gonadotropin releasing hormone (GnRH neuron activity and the pre-ovulatory LH surge. The current studies focus on the expression of kisspeptin during murine fetal development using in situ hybridization (ISH, quantitative reverse transcription real-time PCR (QPCR and immunocytochemistry. Expression of mRNA coding for kisspeptin (KISS1 and its receptor KISS1R was observed at embryonic (E day 13 by ISH. At E13 and other later ages examined, Kiss1 signal in individual cells within the arcuate nucleus (ARC appeared stronger in females than males. ISH examination of agonadal steroidogenic factor-1 (Sf1 knockout mice revealed that E17 XY knockouts resembled wild-type XX females. These findings raise the possibility that gonadal hormones modulate the expression of Kiss1 in the ARC prior to birth. The sex and genotype differences were tested quantitatively by QPCR experiments in dissected hypothalami from mice at E17 and adulthood. Females had significantly more Kiss1 than males at both ages, even though the number of cells detected by ISH was similar. In addition, QPCR revealed a significant difference in the amount of Kiss1 mRNA in Sf1 mice with wild-type (WT XY mice expressing less than XY knockouts (KO and XX mice of both genotypes. The detection of immunoreactive KISS1 in perikarya of the ARC at E17 indicates that early mRNA is translated to peptide. The functional significance of this early expression of Kiss1 awaits elucidation.

  9. Kissing nevus of the penis.

    Science.gov (United States)

    Yun, Sook Jung; Wi, Hyun Seung; Lee, Jee-Bum; Kim, Seong-Jin; Won, Young Ho; Lee, Seung-Chul

    2011-11-01

    Kissing or divided nevi are similar in shape to congenital melanocytic nevi located on an adjacent part of the body that are separated during embryogenesis. Kissing nevi of the upper and lower eyelids have been reported infrequently since the first report in 1908. Kissing nevi of the penis are very rare, with only 12 cases being reported until now, and this is the first case report in the Korean dermatological literature. A previously healthy 27-year-old man presented with asymptomatic black colored patches, which were detected 10 years ago, on the glans penis and the prepuce with growth in size. We report here a case of kissing nevus of the penis, which showed an obvious mirror-image symmetry relative to the coronal sulcus.

  10. Liquor Activity Reduction (LAR) Programme - 12397

    Energy Technology Data Exchange (ETDEWEB)

    Pether, Colin; Carrol, Phil; Birkett, Eddie; Kibble, Matthew [Sellafield Ltd, Cumbria (United Kingdom)

    2012-07-01

    Waste material from the reprocessing of irradiated fuel has been stored under water for several decades leading to the water becoming highly radioactive. As a critical enabler to the decommissioning strategy for the Sellafield site, the Liquor Activity Reduction (LAR) programme has been established to provide a processing route for this highly radioactive liquor. This paper reviews the progress that has been made since the start of routine LAR transfer cycles (July 2010) and follows on from the earlier paper presented at WM2011. The paper focuses on the learning from the first full year of routine LAR transfer cycles and the application of this learning to the wider strategies for the treatment of further radioactive liquid effluents on the Sellafield site. During this period over 100,000 Curies of radioactivity has been safely removed and treated. The past year has witnessed the very successful introduction of the LAR programme. This has lead to hazard reduction at MSSS and demonstration that the SIXEP facility can meet the significantly increased challenge that the LAR programme represents. Part of the success has been the ability to predict and deliver a realistic production schedule with the availability of the MSSS, EDT and SIXEP facilities being central to this. Most importantly, the LAR programme has been successful in bringing together key stakeholders to deliver this work while integrating with the existing, day to day, demands of the Sellafield site. (authors)

  11. Three Kisses%三个吻

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ During our marriage,my wife and I have always exchanged not just one kiss,but three kisses when we departed company. It has brought snickers and chuckles from others,usually our daughters. What is the significance of the three kisses?

  12. Kissing spines: fact or fancy?

    Science.gov (United States)

    Beks, J W

    1989-01-01

    In the Neurosurgical Clinic in Groningen 64 patients underwent surgery between 1975 and 1985 for a clinical and radiological syndrome described by Baastrup in 1933 and called in the Anglo-saxon literature: "kissing spines". Because the results of the surgical treatment were disappointing we submitted these results to further analysis. PMID:2589119

  13. Graduate nuclear engineering programmes motivate educational and research activities

    International Nuclear Information System (INIS)

    Some fifteen years ago the University of Ljubljana, Faculty for Mathematics and Physics together with the national research organisation the J. Stefan jointly established a Graduate programme of Nuclear Engineering. From the onset, the programme focused on nuclear technology, nuclear safety, and reactor physics and environment protection. Over the years this graduate programme has became the focal point of nuclear related, research and educational activities in Slovenia. It has grown into a meeting ground for recognised national and distinguished foreign educators and experienced professionals from the industry. In conjunction with an important national project, supported by the Slovenian government, entitled 'Jung Researcher' it also enhances the knowledge transfer to the next generation. Since the programme was introduced, the interest for this programme has been steadily growing. Accordingly, a number of PhD and MS degrees in NE have been awarded. The graduates of this programme have encountered very good job opportunities in nuclear as well as in non-nuclear sector. (author)

  14. Costs and benefits of Danish active labour market programmes

    DEFF Research Database (Denmark)

    Jespersen, Svend; Munch, Jakob Roland; Skipper, Lars

    2008-01-01

    Since 1994, unemployed workers in the Danish labour market have participated in active labour market programmes on a large scale. This paper contributes with an assessment of costs and benefits of these programmes. Long-term treatment effects are estimated on a very detailed administrative dataset...

  15. Differential regulation of kiss1 expression by melatonin and gonadal hormones in male and female Syrian hamsters

    DEFF Research Database (Denmark)

    Ansel, L; Bolborea, M; Bentsen, A H;

    2010-01-01

    In seasonal breeders, reproduction is synchronized to seasons by day length via the pineal hormone melatonin. Recently, we have demonstrated that Kiss1, a key activator of the reproductive function, is down-regulated in sexually inactive hamsters maintained in inhibitory short days (SDs). In rode......In seasonal breeders, reproduction is synchronized to seasons by day length via the pineal hormone melatonin. Recently, we have demonstrated that Kiss1, a key activator of the reproductive function, is down-regulated in sexually inactive hamsters maintained in inhibitory short days (SDs...... differentially regulate Kiss1 expression in the ARC and the AVPV. Kiss1 expression was examined by in situ hybridization in both male and female hamsters kept in various experimental conditions, and we observed that 1) SD exposure markedly reduced Kiss1 expression in the ARC and AVPV of male and female hamsters...

  16. KEK in Riken. KISS project and KEK Wako Nuclear Science Center

    International Nuclear Information System (INIS)

    Aim of the KEK KISS project is to understand an astrophysical origin of the rapid neutron capture process through the decay studies of unknown nuclei having the mass number around 195 and the neutron number around 126 in so called blank spot region, where has been hard to access experimentally, so far. We have developed a new experimental method consisting of multi-nucleon transfer reactions of neutron-rich heavy-ion beams and a mass separator combined with an element selective laser resonance ionization. This device is named as KEK Isotope Separation System (KISS). After the success of the developments, KISS will be open for users in this year as one of experimental apparatuses in the RIBF facility of Riken Nishina Center. And a KEK new branch, Wako Nuclear Science Center (WNSC) has been launched at Riken Wako campus from this April for supporting the scientific activities of KISS users. (author)

  17. Diversity Programme Activity Report 2012-2015

    CERN Document Server

    Guinot, Genevieve; CERN. Geneva. HR Department

    2016-01-01

    CERN’s Diversity programme was launched in 2012 and is now firmly established as one of the pillars of the Organization’s Human Resources strategy. This report provides information on the actions undertaken in pursuit of the seven diversity strategic objectives set for the period from 2012 to 2015 in the priority areas identified for actions of recruitment, career development and work environment. The report highlights the progress made in anchoring the diversity principles in policies, procedures and practices within the Organization, as well as the persistent difficulties for the Organization to improve the representation of some nationalities and to attract female applicants in science and engineering. It shows a constant increase of female representation in managerial positions and encouraging results in building a diverse talent pool of scientists and engineers through the various student and graduate programmes. The report also outlines how the Diversity Office contributed through several actions,...

  18. Kissing in the Shadow

    Directory of Open Access Journals (Sweden)

    Paul Thomas

    2013-05-01

    Full Text Available 28 August, Newtown, Sydney: following an encounter the day prior at the National Institute for Experimental Arts, they meet again. A fluid discussion around art, perception, philosophy, vision, probabilities, and physics resulted—transforming into an activity of mobile phone photography—a photo-walk, a means of engaging with the world. The walk down King Street is a visual discussion, collected observations of things noted, a probability map, and a becoming, “like the emergence of another world.”

  19. Delimiting Maximal Kissing Configurations in Four Dimensions

    CERN Document Server

    Altschuler, Eric Lewin

    2013-01-01

    How many unit $n-$dimensional spheres can simultaneously touch or kiss a central $n-$dimensional unit sphere? Beyond mathematics this question has implications for fields such as cryptography and the structure of biologic and chemical macromolecules. The kissing number is only known for dimensions 1-4, 8 and 24 (2, 6, 12, 24, 240, 19650, respectively) and only particularly obvious for dimensions one and two. Indeed, in four dimensions it is not even known if Platonic polytope unique to that dimension known as the 24-cell is the unique kissing configuration. We have not been able to prove that the 24-cell is unique, but, using a physical approach utilizing the hopf map from four to three dimensions, we for the first time delimit the possible other configurations which could be kissing in four dimensions.

  20. Biennial activity report of Metallurgy Programme - 1985 and 1986

    International Nuclear Information System (INIS)

    The biennial activity report of the Metallurgy Programme of the Indira Gandhi Centre for Atomic Research covers the period of the years 1985 and 1986. Along with NDT, welding metallurgy, low cycle fatigue, creep and creep fatigue interactions, structure-property correlations, thermodynamics and corrosion metallurgy of alloy steels with respect to their compatibility with aqueous and liquid sodium environments continue to be the major thrust areas of the Programme. Some of the basic research contributions of the Programme are: the observation of uniform and homogeneous distribution of voids in cyclically deformed 304 SS, the role of grain boundaries and precipitation in dynamic strain ageing of 316 SS and the determination of the activities of component metals in 316 and 304 SS by metastable EMF method. (author)

  1. Research reactor activities in support of national nuclear programmes

    International Nuclear Information System (INIS)

    This report is the result of an IAEA Technical Committee Meeting on Research Reactor Activities in Support of National Nuclear Programmes held in Budapest, Hungary during 10-13 December 1985. The countries represented were Belgium, Finland, France, Federal Republic of Germany, German Democratic Republic, India, Poland, Spain, United Kingdom, United States, Yugoslavia and Hungary. The purpose of the meeting was to present information and details of several well-utilized research reactors and to discuss their contribution to national nuclear programmes. A related Agency activity, a Seminar on Applied Research and Service Activities for Research Reactor Operations was held in Copenhagen, Denmark during 9-13 September 1985. Selected papers from this Seminar relevant to the topic of research reactor support of national nuclear programmes have been included in this report. A separate abstract was prepared for each of 19 papers presented at the Technical Committee Meeting on Research Reactor Activities in Support of National Nuclear Programmes and for each of 15 papers selected from the presentations of the Seminar on Applied Research and Service Activities for Research Reactor Operations

  2. Primer on CDM programme of activities

    Energy Technology Data Exchange (ETDEWEB)

    Hinostroza, M. (UNEP Risoe Centre, Roskilde (Denmark)); Lescano, A.D. (A2G Carbon Partners (Peru)); Alvarez, J.M. (Ministerio del Ambiente del Peru (Peru)); Avendano, F.M. (EEA Fund Management Ltd. (United Kingdom)

    2009-07-01

    As an advanced modality introduced in 2005, the Programmatic CDM (POA) is expected to address asymmetries of participation, especially of very small-scale project activities in certain areas, key sectors and many countries with considerable potential for greenhouse gas emission reductions, not reached by the traditional single-project-based CDM. Latest experiences with POAs and the recently finalized official guidance governing the Programmatic CDM are the grassroots of this Primer, which has the purpose of supporting the fully understanding of rules and procedures of POAs by interpreting them and analyzing real POA cases. Professional and experts from the public and private entities have contributed to the development of this Primer, produced by the UNEP Risoe Centre, as part of knowledge support activities for the Capacity Development for the CDM (CD4CDM) project. The overall objective of the CD4CDM is to develop the capacities of host countries to identify, design, approve, finance, implement CDM projects and commercialize CERs in participating countries. The CDM4CDM is funded by the Netherlands Ministry of Foreign Affairs. (author)

  3. Certain aspects of the psychological analysis of programmer activity. [selection of computer programmers

    Science.gov (United States)

    Bondarovskaya, V. M.

    1975-01-01

    The psychological analysis of programmer activity showed that one of its basic characteristics is the need to employ formal languages. In determining ways of effectively mastering the capacity to write algorithms in the algorithmic language, it is expedient to proceed from its similarity to the living languages and the language of mathematical formulas, and to choose certain psychological principles of mastering foreign languages and mathematical symbols in teaching the algorithmic language. General models of the input language significantly increase the effectiveness of its mastery and permit the development of thinking on the part of the students.

  4. In silico analysis of the regulatory region of the Yellowtail Kingfish and Zebrafish Kiss and Kiss receptor genes.

    Science.gov (United States)

    Nocillado, J N; Mechaly, A S; Elizur, A

    2013-02-01

    We have cloned and analysed the partial putative promoter sequences of the Yellowtail Kingfish (Seriola lalandi) Kiss2 and Kiss2r genes (380 and 420 bp, respectively). We obtained in silico 1.5 kb of the zebrafish (Danio rerio) Kiss1, Kiss2, Kiss1r and zfKiss2r sequences upstream of the putative transcriptional initiation site. Bioinformatic analysis revealed promoter regulatory elements including AP-1, Sp1, GR, ER, PR, AR, GATA-1, TTF-1, YY1 and C/EBP. These regulatory elements may mediate novel roles of the Kiss genes and their receptors in addition to their established role in reproductive function. PMID:22527613

  5. Issues related to a programme of activities under the CDM

    Energy Technology Data Exchange (ETDEWEB)

    Ellis, J.

    2006-05-15

    Emissions of CO2 from the energy and land-use change and forestry sectors are responsible for the majority of emissions in non-Annex I Parties to the UNFCCC. Tackling greenhouse gas (GHG) emissions from these sectors is a key to slowing the growth in GHG emissions in non-Annex I countries. Implementing Clean Development Mechanism (CDM) projects can help achieve this aim, while also assisting non-Annex I countries to move towards sustainable development and Annex I countries achieve their emission commitments under the Kyoto Protocol. There has been rapid progress in the CDM over the last year - in terms of the number of projects in the pipeline and registered, and in terms of credits issued. However, some important sectors are notable by their small share in the CDM portfolio. Several countries have also called attention to the need to accelerate the process of approving CDM methodologies and projects. In order to improve the effectiveness of the CDM to achieve its dual objectives, the COP/MOP agreed a decision on 'further guidance relating to the clean development mechanism. This decision lays out guidance on how to improve the operation of the CDM, and includes provisions that allow: (1) Bundling of project activities; and (2) Project activities under a programme of activities, to be registered as a CDM project activity. At present, of the 172 currently registered CDM project activities, 27 involve programmes or bundles. These project activities can include more than one project type, be implemented in several locations, and/or occur in more than one sector. This paper assesses how project activities under a programme of activities under the CDM (referred to here as PCDM) could help to increase the effectiveness of the CDM by encouraging a wide spread of emission mitigation activities. This paper also explores the key issues that may need to be considered for the PCDM concept to be further implemented. The paper concludes that: (1) Key concepts and issues

  6. Active-Pixel Image Sensors With Programmable Resolution

    Science.gov (United States)

    Kemeny, Sabrina E.; Fossum, Eric R.; Pain, Bedabrata; Nakamura, Junichi; Matthies, Larry H.

    1996-01-01

    Active-pixel image sensors with programmable resolution proposed for use in applications in which speed and efficiency of processing of image data enhanced by providing those data at varying resolutions. Such applications include modeling of biological vision, stereoscopic range-finding, recognition of patterns, tracking targets, and progressive transmission of compressed images. In target-tracking application, sensor initially forms low-resolution image from which area of interest identified, then sensor set at high resolution for examination of identified area. Outputs of contiguous pixels combined. Sensor of this type made to act as though it comprised fewer and larger pixels.

  7. Kiss-induced severe anaphylactic reactions

    Directory of Open Access Journals (Sweden)

    Atanasković-Marković Marina

    2010-01-01

    Full Text Available Introduction. Ingestion is the principal route for food allergens to trigger allergic reaction in atopic persons. However, in some highly sensitive patients severe symptoms may develop upon skin contact and by inhalation. The clinical spectrum ranges from mild facial urticaria and angioedema to life-threatening anaphylactic reactions. Outline of Cases. We describe cases of severe anaphylactic reactions by skin contact, induced by kissing in five children with prior history of severe anaphylaxis caused by food ingestion. These cases were found to have the medical history of IgE mediated food allergy, a very high total and specific serum IgE level and very strong family history of allergy. Conclusion. The presence of tiny particles of food on the kisser's lips was sufficient to trigger an anaphylactic reaction in sensitized children with prior history of severe allergic reaction caused by ingestion of food. Allergic reaction provoked with food allergens by skin contact can be a risk factor for generalized reactions. Therefore, extreme care has to be taken in avoiding kissing allergic children after eating foods to which they are highly allergic. Considering that kissing can be a cause of severe danger for the food allergic patient, such persons should inform their partners about the risk factor for causing their food hypersensitivity.

  8. Kiso Supernova Survey (KISS): Survey Strategy

    CERN Document Server

    Morokuma, Tomoki; Tanaka, Masaomi; Mori, Kensho; Matsumoto, Emiko; Kikuchi, Yuki; Shibata, Takumi; Sako, Shigeyuki; Aoki, Tsutomu; Doi, Mamoru; Kobayashi, Naoto; Maehara, Hiroyuki; Matsunaga, Noriyuki; Mito, Hiroyuki; Miyata, Takashi; Nakada, Yoshikazu; Soyano, Takao; Tarusawa, Ken'ichi; Miyazaki, Satoshi; Nakata, Fumiaki; Okada, Norio; Sarugaku, Yuki; Richmond, Michael W; Akitaya, Hiroshi; Aldering, Greg; Arimatsu, Ko; Contreras, Carlos; Horiuchi, Takashi; Hsiao, Eric Y; Itoh, Ryosuke; Iwata, Ikuru; Koji,; Kawabata, S; Kawai, Nobuyuki; Kitagawa, Yutaro; Kokubo, Mitsuru; Kuroda, Daisuke; Paolo,; Mazzali,; Misawa, Toru; Moritani, Yuki; Morrell, Nidia; Okamoto, Rina; Pavlyuk, Nikolay; Phillips, Mark M; Pian, Elena; Sahu, Devendra; Saito, Yoshihiko; Sano, Kei; Stritzinger, Maximilian D; Tachibana, Yutaro; Taddia, Francesco; Takaki, Katsutoshi; Tateuchi, Ken; Tomita, Akihiko; Tsvetkov, Dmitry; Ui, Takahiro; Ukita, Nobuharu; Urata, Yuji; Walker, Emma S; Yoshii, Taketoshi

    2014-01-01

    The Kiso Supernova Survey (KISS) is a high-cadence optical wide-field supernova (SN) survey. The primary goal of the survey is to catch the very early light of a SN, during the shock breakout phase. Detection of SN shock breakouts combined with multi-band photometry obtained with other facilities would provide detailed physical information on the progenitor stars of SNe. The survey is performed using a 2.2x2.2 deg field-of-view instrument on the 1.05-m Kiso Schmidt telescope, the Kiso Wide Field Camera (KWFC). We take a three-minute exposure in g-band once every hour in our survey, reaching magnitude g~20-21. About 100 nights of telescope time per year have been spent on the survey since April 2012. The number of the shock breakout detections is estimated to be of order of 1 during our 3-year project. This paper summarizes the KISS project including the KWFC observing setup, the survey strategy, the data reduction system, and CBET-reported SNe discovered so far by KISS.

  9. Differential regulation of kiss1 expression by melatonin and gonadal hormones in male and female Syrian hamsters

    DEFF Research Database (Denmark)

    Ansel, L; Bolborea, M; Bentsen, A H;

    2010-01-01

    In seasonal breeders, reproduction is synchronized to seasons by day length via the pineal hormone melatonin. Recently, we have demonstrated that Kiss1, a key activator of the reproductive function, is down-regulated in sexually inactive hamsters maintained in inhibitory short days (SDs). In rode......In seasonal breeders, reproduction is synchronized to seasons by day length via the pineal hormone melatonin. Recently, we have demonstrated that Kiss1, a key activator of the reproductive function, is down-regulated in sexually inactive hamsters maintained in inhibitory short days (SDs......). In rodents, Kiss1 is expressed in the anteroventral periventricular nucleus (AVPV) and in the arcuate nucleus (ARC). Because both the duration of the nocturnal peak of melatonin and circulating sex steroid levels vary with photoperiod, the aim of this study was to determine whether melatonin and sex steroids...... as compared to LD animals, 2) sex steroid treatment in SD-adapted male and female hamsters increased the number of Kiss1 neurons in the AVPV but decreased it in the ARC, 3) melatonin administration to LD-adapted hamsters decreased Kiss1 mRNA level in both the AVPV and the ARC in intact animals, whereas...

  10. High accuracy semidefinite programming bounds for kissing numbers

    NARCIS (Netherlands)

    Mittelmann, H.D.; Vallentin, F.

    2009-01-01

    The kissing number in n-dimensional Euclidean space is the maximal number of non-overlapping unit spheres which simultaneously can touch a central unit sphere. Bachoc and Vallentin developed a method to find upper bounds for the kissing number based on semidefinite programming. This paper is a repor

  11. An inexpensive programmable illumination microscope with active feedback

    Science.gov (United States)

    Tompkins, Nathan; Fraden, Seth

    2016-01-01

    We have developed a programmable illumination system capable of tracking and illuminating numerous objects simultaneously using only low-cost and reused optical components. The active feedback control software allows for a closed-loop system that tracks and perturbs objects of interest automatically. Our system uses a static stage where the objects of interest are tracked computationally as they move across the field of view allowing for a large number of simultaneous experiments. An algorithmically determined illumination pattern can be applied anywhere in the field of view with simultaneous imaging and perturbation using different colors of light to enable spatially and temporally structured illumination. Our system consists of a consumer projector, camera, 35-mm camera lens, and a small number of other optical and scaffolding components. The entire apparatus can be assembled for under $4,000. PMID:27642182

  12. Long-term effect of a school-based physical activity program (KISS on fitness and adiposity in children: a cluster-randomized controlled trial.

    Directory of Open Access Journals (Sweden)

    Ursina Meyer

    Full Text Available School-based intervention studies promoting a healthy lifestyle have shown favorable immediate health effects. However, there is a striking paucity on long-term follow-ups. The aim of this study was therefore to assess the 3 yr-follow-up of a cluster-randomized controlled school-based physical activity program over nine month with beneficial immediate effects on body fat, aerobic fitness and physical activity.Initially, 28 classes from 15 elementary schools in Switzerland were grouped into an intervention (16 classes from 9 schools, n = 297 children and a control arm (12 classes from 6 schools, n = 205 children after stratification for grade (1st and 5th graders. Three years after the end of the multi-component physical activity program of nine months including daily physical education (i.e. two additional lessons per week on top of three regular lessons, short physical activity breaks during academic lessons, and daily physical activity homework, 289 (58% participated in the follow-up. Primary outcome measures included body fat (sum of four skinfolds, aerobic fitness (shuttle run test, physical activity (accelerometry, and quality of life (questionnaires. After adjustment for grade, gender, baseline value and clustering within classes, children in the intervention arm compared with controls had a significantly higher average level of aerobic fitness at follow-up (0.373 z-score units [95%-CI: 0.157 to 0.59, p = 0.001] corresponding to a shift from the 50th to the 65th percentile between baseline and follow-up, while the immediate beneficial effects on the other primary outcomes were not sustained.Apart from aerobic fitness, beneficial effects seen after one year were not maintained when the intervention was stopped. A continuous intervention seems necessary to maintain overall beneficial health effects as reached at the end of the intervention.ControlledTrials.com ISRCTN15360785.

  13. Active Labour Market Programmes and Unemployment in a Dual Labour Market

    OpenAIRE

    Fukushima, Yoshihiko

    1998-01-01

    The paper presents a theoretical analysis of the macroeconomic effects of active labour market programmes in a dual labour-market framework. The paper uses the Shapiro-Stiglitz efficiency-wage model. Active labour market programmes train unskilled labour and transfer them from a high-unemployment to a low-unemployment sector. Programmes have a direct labour-transfer effect which tends to reduce total unemployment. They also have effects on wages via expectations. The later effects were to a v...

  14. Programme Costing of a Physical Activity Programme in Primary Prevention: Should the Costs of Health Asset Assessment and Participatory Programme Development Count?

    Directory of Open Access Journals (Sweden)

    Silke B. Wolfenstetter

    2012-01-01

    Full Text Available This analysis aims to discuss the implications of the “health asset concept”, introduced by the WHO, and the “investment for health model” requiring a “participatory approach” of cooperative programme development applied on a physical activity programme for socially disadvantaged women and to demonstrate the related costing issues as well as the relevant decision context. The costs of programme implementation amounted to €48,700. Adding the costs for developing the programme design of €48,800 results in total costs of €97,500; adding on top of that the costs of asset assessment running to €35,600 would total €133,100. These four different cost figures match four different types of potentially relevant decisions contexts. Depending on the decision context the total costs, and hence the incremental cost-effectiveness ratio of a health promotion intervention, could differ considerably. Therefore, a detailed cost assessment and the identification of the decision context are of crucial importance.

  15. Adult Workers in Theory or Practice? : Lone Mothers’ Participation in Active Labour Market Programmes in Germany

    OpenAIRE

    Cordula Zabel

    2015-01-01

    This paper examines lone mothers’ participation in active labour market programmes in Germany. Since the 2005 Hartz IV employment and welfare policy reforms, expectations that non-em- ployed parents receiving means-tested benefits should be ready for employment or labour market programme participation have grown stronger. However, discretion for programme assignments is left to individual caseworkers. As a consequence, it is not clear to what extent the formal policy orientation towards an ad...

  16. Baastrup’s disease: The kissing spine

    Science.gov (United States)

    Singla, Amit; Shankar, Vivek; Mittal, Samarth; Agarwal, Abhinav; Garg, Bhavuk

    2014-01-01

    A 67-year-old male presented with a gradually progressive low back pain of 2 years duration. The patient was leading a retired life and there was no history of chronic fever or significant trauma. There was no radiation of pain or any features suggestive of claudication. There was no history of any comorbidity. The pain was aggravated with extension of the spine and relieved with flexion. There was no swelling or neurological deficit, but muscle spasm was present. Radiographs of the spine revealed degenerative changes in the lumbosacral spine, along with articulation of spinous processes at in lumbar spine at all levels level suggestive of Baastrup’s disease, commonly known as “kissing spine”. Routine blood investigations were within normal limits. The patient was managed conservatively. He was given a week’s course of analgesics and muscle relaxants and then started on spinal flexion exercises, with significant improvement being noted at 6 months follow up. PMID:24579072

  17. Off-line test of the KISS gas cell

    Energy Technology Data Exchange (ETDEWEB)

    Hirayama, Yoshikazu, E-mail: yoshikazu.hirayama@kek.jp [Institute of Particle and Nuclear Studies (IPNS), High Energy Accelerator Research Organization (KEK), Ibaraki 305-0801 (Japan); Watanabe, Yutaka; Imai, Nobuaki; Ishiyama, Hironobu; Jeong, Sun-Chan; Miyatake, Hiroari; Oyaizu, Michihiro [Institute of Particle and Nuclear Studies (IPNS), High Energy Accelerator Research Organization (KEK), Ibaraki 305-0801 (Japan); Kim, Yung Hee [Seoul National University, Seoul 151 742 (Korea, Republic of); Mukai, Momo [Tsukuba University, Ibaraki 305 0006 (Japan); Matsuo, Yukari; Sonoda, Tetsu; Wada, Michiharu [Nishina Center for Accelerator-Based Science, RIKEN, Wako, Saitama 351 0198 (Japan); Huyse, Mark; Kudryavtsev, Yuri; Van Duppen, Piet [Instituut voor Kern-en Stralingsfysica, KU Leuven, B-3001 Leuven (Belgium)

    2013-12-15

    Highlights: • Construction of the KEK Isotope Separation System (KISS) at RIKEN. • Ionization scheme of an iron. • Measurement of transport time profile in a gas cell. -- Abstract: The KEK Isotope Separation System (KISS) has been constructed at RIKEN to study the β-decay properties of neutron-rich isotopes with neutron numbers around N = 126 for application to astrophysics. A key component of KISS is a gas cell filled with argon gas at a pressure of 50 kPa to stop and collect the unstable nuclei, where the isotopes of interest will be selectively ionized using laser resonance ionization. We have performed off-line tests to study the basic properties of the gas cell and of KISS using nickel and iron filaments placed in the gas cell.

  18. Earth observation space programmes, SAFISY activities, strategies of international organisations, legal aspects. Volume 3

    International Nuclear Information System (INIS)

    This volume is separated in four sessions. First part is on earth observation space programmes (international earth observation projects and international collaboration, the ERS-1, SPOT and PRIRODA programmes, the first ESA earth observation polar platform and its payload, the future earth observation remote sensing techniques and concepts). The second part is on SAFISY activities (ISY programmes, education and applications, demonstrations and outreach projects). The third part is on programme and strategies of international organisations with respect to earth observation from space. The fourth part is on legal aspects of the use of satellite remote sensing data in Europe. (A.B.). refs., figs., tabs

  19. A telecare programme for self-management of COPD exacerbations and promotion of an active lifestyle

    NARCIS (Netherlands)

    Tabak, Monique; Brusse-Keizer, Marjolein; Ommeren, Clara; Kotte, Hayke; Weltevreden, Paul; Hermens, Hermie; Vollenbroek-Hutten, Miriam

    2013-01-01

    Objective: The Condition Coach (CoCo) is a technology-supported care programme for self-management of COPD exacerbations and for promotion of an active lifestyle. The objective is to investigate the added value of the telecare programme in terms of clinical changes compared to usual care, and in add

  20. Kissing reduces allergic skin wheal responses and plasma neurotrophin levels.

    Science.gov (United States)

    Kimata, Hajime

    2003-11-01

    The effect of kissing on allergen-induced skin wheal responses and plasma neurotrophin levels were studied in 30 normal subjects, 30 patients with allergic rhinitis (AR), and 30 patients with atopic dermatitis (AD). All of the patients with AR or AD are allergic to house dust mite (HDM) and Japanese cedar pollen (JCP). They are all Japanese and they do not kiss habitually. The subject kissed freely during 30 min with their lover or spouse alone in a room with closed doors while listening to soft music. Before and after kissing, skin prick tests were performed using commercial HDM allergen, JCP allergen, as well as histamine and control solution, and wheal responses were measured. Simultaneously, plasma levels of neurotrophin, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and -4 (NT-4) were measured. Kissing significantly reduced wheal responses induced by HDM and JCP, but not by histamine, and decreased plasma levels of NGF, BDNF, NT-3, and NT-4 in patients with AR or AD, while it failed to do so in normal subjects. These finding indicate that kissing have some implication in the study of neuroimmunology in allergic patients. PMID:14637240

  1. Combustion chemistry - activities in the CHEK research programme

    Energy Technology Data Exchange (ETDEWEB)

    Dam-Johansen, K.; Johnsson, J.E.; Glarborg, P.; Frandsen, F.; Jensen, A.; Oestberg, M. [Technical Univ. of Denmark, Lyngby (Denmark). Dept. of Chemical Engineering

    1997-10-01

    The combustion chemistry in the oxidation of fossil fuels and biofuels determines together with mixing and heat transfer the required size of a furnace, the emission of gaseous pollutants, and the formation of ash and deposits on surfaces. This presentation describes technologies for solid fuels combustion and gives a summary of the fuels, the pollutant chemistry and the inorganic chemistry in combustion processes. Emphasis is put on the work carried out in the CHEC (Combustion and Harmful Emission Control) Research Programme. (orig.)

  2. The Effect of Sanctions and Active Labour Market Programmes on the Exit Rate From Unemployment

    DEFF Research Database (Denmark)

    Ahmad, Nisar; Svarer, Michael

    2009-01-01

    ). Hence, modeling only one of them as treatment might over or underestimate the true effect. Therefore, by using a multivariate mixed proportional hazard model (MMPH), we model the hazard rate out of unemployment along with the sanction rate and hazard rate into active labour market programmes. We......This paper simultaneously investigates the effectiveness of benefit sanctions and active labour market programmes on the exit rate from unemployment using Danish data. In the data about one third of the individuals who are sanctioned also participate in some active labour market programmes (ALMPs...... optimally select the number of supports point for the distribution of unobserved heterogeneity. Results show that pre-specifying two support points underestimates the effect of sanctions and active labour market programmes. Failing to control for selectivity for sanctions not only underestimates...

  3. Reason and Condition for Mode Kissing in MASW Method

    Science.gov (United States)

    Gao, Lingli; Xia, Jianghai; Pan, Yudi; Xu, Yixian

    2016-05-01

    Identifying correct modes of surface waves and picking accurate phase velocities are critical for obtaining an accurate S-wave velocity in MASW method. In most cases, inversion is easily conducted by picking the dispersion curves corresponding to different surface-wave modes individually. Neighboring surface-wave modes, however, will nearly meet (kiss) at some frequencies for some models. Around the frequencies, they have very close roots and energy peak shifts from one mode to another. At current dispersion image resolution, it is difficult to distinguish different modes when mode-kissing occurs, which is commonly seen in near-surface earth models. It will cause mode misidentification, and as a result, lead to a larger overestimation of S-wave velocity and error on depth. We newly defined two mode types based on the characteristics of the vertical eigendisplacements calculated by generalized reflection and transmission coefficient method. Rayleigh-wave mode near the kissing points (osculation points) change its type, that is to say, one Rayleigh-wave mode will contain different mode types. This mode type conversion will cause the mode-kissing phenomenon in dispersion images. Numerical tests indicate that the mode-kissing phenomenon is model dependent and that the existence of strong S-wave velocity contrasts increases the possibility of mode-kissing. The real-world data shows mode misidentification caused by mode-kissing phenomenon will result in higher S-wave velocity of bedrock. It reminds us to pay attention to this phenomenon when some of the underground information is known.

  4. From activity to learning: using cultural historical activity theory to model school library programmes and practices

    Directory of Open Access Journals (Sweden)

    E.M. Meyers

    2007-01-01

    Full Text Available Introduction. changes in educational policy and practice demand that we examine school library programmes from a new perspective. As a model that takes a developmental view of minds in context, Cultural Historical Activity Theory is particularly well suited to the study of school libraries and the learning that occurs therein. This paper focuses on the activity theoretic concepts of 'contradictions' and 'expansive learning' as they relate to the development of best practices. Method. Developmental Work Research was applied as a guiding methodology in an intervention study of six high school libraries in Washington State, USA. Library activity is illustrated from multiple perspectives using a triangulated, qualitative approach. Analysis. contradictions and tensions in the general school library activity system are identified, and an intervention was designed to facilitiate the development of expansive instruments. A case example illustrates a second level of analysis and specific points of intervention. Results. analysis reveals that the tensions and contradictions provide opportunities for expansive learning on the part of the teacher-Librarians. The research team can use practitioners' zones of proximal development to guide the alignment of library programme goals and practices. Conclusion. : some limitations and future promise of the framework and its application are discussed. The proposed activity theory toolkit suggest a new way of exploring the practices of teacher-librarians, incorporating research evidence, professional expertise, and reflective decision making.

  5. Combustion chemistry. Activities in the CHEC research programme

    Energy Technology Data Exchange (ETDEWEB)

    Dam-Johansen, K.; Johnsson, J.E.; Glarborg, P.; Frandsen, F.; Jensen, A.; Oestberg, M. [Technical Univ. of Denmark, Dept. of Chemical Engineering, Lyngby (Denmark)

    1996-12-01

    The combustion chemistry in the oxidation of fossil fuels and biofuels determines together with mixing and heat transfer the required size of a furnace, the emission of gaseous pollutants, and the formation of ash and deposits on surfaces. This paper describes technologies for solid fuels combustion and gives a summary of the fuels, the pollutant chemistry and the inorganic chemistry in combustion processes. Emphasis is put on the work carried out in the CHEC (Combustion and Harmful Emission Control Research Programme). (au) 173 refs.

  6. Adult Workers in Theory or Practice? : Lone Mothers’ Participation in Active Labour Market Programmes in Germany

    Directory of Open Access Journals (Sweden)

    Cordula Zabel

    2015-03-01

    Full Text Available This paper examines lone mothers’ participation in active labour market programmes in Germany. Since the 2005 Hartz IV employment and welfare policy reforms, expectations that non-em- ployed parents receiving means-tested benefits should be ready for employment or labour market programme participation have grown stronger. However, discretion for programme assignments is left to individual caseworkers. As a consequence, it is not clear to what extent the formal policy orientation towards an adult worker model of the family is reflected in practical policy implemen- tations. Thus, lone mothers’ participation in active labour market programmes is studied empiri- cally here on the basis of large-scale administrative data, using event-history analysis. Findings are that lone mothers are treated as adult workers with respect to workfare and training pro- grammes even when their children are still quite young. As soon as their youngest child is 3 - 5 years old, lone mothers’ transition rates into these programmes are as high as for childless single women. In the case of programmes that provide more direct pathways into regular employment, like job subsidies and in-firm training programmes, however, participation rates for lone mothers of young children are substantially lower than for childless single women.

  7. Are they working? Market Orientation and the Effectiveness of Active Labour Market Programmes in Ireland

    OpenAIRE

    Philip J O'Connell

    1999-01-01

    This paper presents the first findings of a new study of the labour market impact of a range of active labour market programmes (ALMPs) in Ireland. The paper combines the results of two individual-level data sets to compare the employment outcomes of participants in ALMPs with a comparison group of non-participants over the 1994-1996 period. The analysis focuses on employment probabilities two years post-programme, and shows that programmes with strong linkages to the labour market are more l...

  8. The Kiss2 receptor (Kiss2r) gene in Southern Bluefin Tuna, Thunnus maccoyii and in Yellowtail Kingfish, Seriola lalandi - functional analysis and isolation of transcript variants.

    Science.gov (United States)

    Nocillado, J N; Biran, J; Lee, Y Y; Levavi-Sivan, B; Mechaly, A S; Zohar, Y; Elizur, A

    2012-10-15

    The kisspeptin system plays an essential role in reproductive function in vertebrates, particularly in the onset of puberty. We investigated the kisspeptin system in two Perciform teleosts, the Southern Bluefin Tuna (SBT; Thunnus maccoyii), and the Yellowtail Kingfish (YTK; Seriola lalandi), by characterising their kisspeptin 2 receptor (Kiss2r) genes. In addition to the full length Kiss2r cDNA sequences, we have isolated from SBT and YTK a transcript variant that retained an intron. We have further obtained three ytkKiss2r transcript variants that contained deletions. In vitro functional analysis of the full length SBT and YTK Kiss2r showed higher response to Kiss2-10 than to Kiss1-10, with stronger transduction via PKC than PKA. The full length ytkKiss2r and two deletion variants were differentially expressed in the brain of male, but not in female, juvenile YTK treated with increasing doses of Kiss2-10 peptide. In the gonads, the expression level of the ytkKiss2r transcripts did not vary significantly either in the male or female fish. This is the first time that transcript variants of the Kiss2r gene that contain deletions and show responsiveness to treatments with kisspeptin have been reported in any teleost. PMID:22824208

  9. Kissing nevus of the penis. Report of two cases and review of the literature.

    Science.gov (United States)

    Wang, Songting; Zhou, Mingshu; Qiao, Jianjun

    2014-01-01

    Kissing nevus is a curious type of nevus that was first described on the eyelids and rarely described on the penis. We report two cases of kissing nevus of the penis and review previously reported cases. The lesions of the kissing nevus of the penis showed characteristic mirror-image symmetry relative to the coronal sulcus. On histopathology, the lesion showed a compound nevus.

  10. Kissing nevus of the penis. Report of two cases and review of the literature *

    OpenAIRE

    Wang, Songting; Zhou, Mingshu; Qiao, Jianjun

    2014-01-01

    Kissing nevus is a curious type of nevus that was first described on the eyelids and rarely described on the penis. We report two cases of kissing nevus of the penis and review previously reported cases. The lesions of the kissing nevus of the penis showed characteristic mirror-image symmetry relative to the coronal sulcus. On histopathology, the lesion showed a compound nevus.

  11. Applying a nonlinear, pitch-catch, ultrasonic technique for the detection of kissing bonds in friction stir welds.

    Science.gov (United States)

    Delrue, Steven; Tabatabaeipour, Morteza; Hettler, Jan; Van Den Abeele, Koen

    2016-05-01

    Friction stir welding (FSW) is a promising technology for the joining of aluminum alloys and other metallic admixtures that are hard to weld by conventional fusion welding. Although FSW generally provides better fatigue properties than traditional fusion welding methods, fatigue properties are still significantly lower than for the base material. Apart from voids, kissing bonds for instance, in the form of closed cracks propagating along the interface of the stirred and heat affected zone, are inherent features of the weld and can be considered as one of the main causes of a reduced fatigue life of FSW in comparison to the base material. The main problem with kissing bond defects in FSW, is that they currently are very difficult to detect using existing NDT methods. Besides, in most cases, the defects are not directly accessible from the exposed surface. Therefore, new techniques capable of detecting small kissing bond flaws need to be introduced. In the present paper, a novel and practical approach is introduced based on a nonlinear, single-sided, ultrasonic technique. The proposed inspection technique uses two single element transducers, with the first transducer transmitting an ultrasonic signal that focuses the ultrasonic waves at the bottom side of the sample where cracks are most likely to occur. The large amount of energy at the focus activates the kissing bond, resulting in the generation of nonlinear features in the wave propagation. These nonlinear features are then captured by the second transducer operating in pitch-catch mode, and are analyzed, using pulse inversion, to reveal the presence of a defect. The performance of the proposed nonlinear, pitch-catch technique, is first illustrated using a numerical study of an aluminum sample containing simple, vertically oriented, incipient cracks. Later, the proposed technique is also applied experimentally on a real-life friction stir welded butt joint containing a kissing bond flaw. PMID:26921559

  12. Applying a nonlinear, pitch-catch, ultrasonic technique for the detection of kissing bonds in friction stir welds.

    Science.gov (United States)

    Delrue, Steven; Tabatabaeipour, Morteza; Hettler, Jan; Van Den Abeele, Koen

    2016-05-01

    Friction stir welding (FSW) is a promising technology for the joining of aluminum alloys and other metallic admixtures that are hard to weld by conventional fusion welding. Although FSW generally provides better fatigue properties than traditional fusion welding methods, fatigue properties are still significantly lower than for the base material. Apart from voids, kissing bonds for instance, in the form of closed cracks propagating along the interface of the stirred and heat affected zone, are inherent features of the weld and can be considered as one of the main causes of a reduced fatigue life of FSW in comparison to the base material. The main problem with kissing bond defects in FSW, is that they currently are very difficult to detect using existing NDT methods. Besides, in most cases, the defects are not directly accessible from the exposed surface. Therefore, new techniques capable of detecting small kissing bond flaws need to be introduced. In the present paper, a novel and practical approach is introduced based on a nonlinear, single-sided, ultrasonic technique. The proposed inspection technique uses two single element transducers, with the first transducer transmitting an ultrasonic signal that focuses the ultrasonic waves at the bottom side of the sample where cracks are most likely to occur. The large amount of energy at the focus activates the kissing bond, resulting in the generation of nonlinear features in the wave propagation. These nonlinear features are then captured by the second transducer operating in pitch-catch mode, and are analyzed, using pulse inversion, to reveal the presence of a defect. The performance of the proposed nonlinear, pitch-catch technique, is first illustrated using a numerical study of an aluminum sample containing simple, vertically oriented, incipient cracks. Later, the proposed technique is also applied experimentally on a real-life friction stir welded butt joint containing a kissing bond flaw.

  13. Activity and health prevention in preschools--contents of an activity-based intervention programme (PAKT--Prevention through Activity in Kindergarten Trial)

    OpenAIRE

    Roth, Kristina; Mauer, Sonja; Obinger, Matthias; Lenz, Dorothea; Hebestreit, Helge

    2011-01-01

    Abstract Aim To establish an effective and feasible physical activity intervention programme for preschools. Methods A multicomponent physical activity intervention programme with three components was developed for the preschool setting based on the psychomotor concept: daily structured physical education lessons for the children provided by the kindergarten teachers, physical activity homework for the chi...

  14. Objects prompt authentic scientific activities among learners in a museum programme

    Science.gov (United States)

    Achiam, Marianne; Simony, Leonora; Kramer Lindow, Bent Erik

    2016-04-01

    Although the scientific disciplines conduct practical work in different ways, all consider practical work as the essential way of connecting objects and phenomena with ideas and the abstract. Accordingly, practical work is regarded as central to science education as well. We investigate a practical, object-based palaeontology programme at a natural history museum to identify how palaeontological objects prompt scientific activity among upper secondary school students. We first construct a theoretical framework based on an analysis of the programme's palaeontological content. From this, we build our reference model, which considers the specimens used in the programme, possible palaeontological interpretations of these specimens, and the conditions inherent in the programme. We use the reference model to analyse the activities of programme participants, and illustrate how these activities are palaeontologically authentic. Finally, we discuss our findings, examining the mechanism by which the specimens prompt scientific activities. We also discuss our discipline-based approach, and how it allows us to positively identify participants' activities as authentic. We conclude by discussing the implications of our findings.

  15. IAEA activities related to research reactor fuel conversion and spent fuel return programmes

    International Nuclear Information System (INIS)

    Full text: The IAEA has been involved for more than twenty years in supporting international nuclear non-proliferation efforts associated with reducing the amount of highly enriched uranium (HEU) in international commerce. IAEA projects and activities have directly supported the Reduced Enrichment for Research and Test Reactors (RERTR) programme, as well as directly associated efforts to return research reactor fuel to the country of origin where it was originally enriched. IAEA efforts have included the development and maintenance of several data bases with information related to research reactors and research reactor spent fuel inventories that have been essential in planning and managing both RERTR and spent fuel return programmes. Other IAEA regular budget programmes have supported research reactor fuel conversion from HEU to low enriched uranium, and in addressing issues common to many member states with spent fuel management problems and concerns. The paper briefly describes IAEA involvement since the early 1980's in these areas, including regular budget and Technical Co-operation programme activities, and focuses on efforts in the past five years to continue to support and accelerate U.S. and Russian research reactor spent fuel return programmes. It is hoped that an announcement of the extension of the U.S. Acceptance Programme, which is expected in the very near future, will facilitate the life extensions of many productive TRIGA reactors around the world. (author)

  16. The radiation protection programme activities of the World Health Organization

    International Nuclear Information System (INIS)

    The radiation protection activities of the World Health Organization are reviewed. They include studies of radiation protection standards and guidelines, and public health aspects of nuclear power. WHO also provides member states with world data on radioactivity in air, water and food, and assessments of population exposure and health effects. (H.K.)

  17. What works, who works? The impact of active labour market programmes on the employment prospects of young people in Ireland

    OpenAIRE

    O'Connell, Philip J.; MacGinnity, Fran

    1996-01-01

    The international literature on active labour market programmes has generated inconsistent and confusing, but generally pessimistic, conclusions regarding their impact on the employment prospects of participants. This paper argues that much of this confusion is due to a general lack of attention to qualitative differences between programmes. The paper develops a typology of active labour market programmes, differentiating between training and employment measures on the basis of their orientat...

  18. The Effect of Sanctions and Active Labour Market Programmes on the Exit Rate From Unemployment

    DEFF Research Database (Denmark)

    Ahmad, Nisar; Svarer, Michael

    ). Hence, modeling only one of them as treatment might over or underestimate the true effect. Therefore, by using a multivariate mixed proportional hazard model (MMPH), we model the hazard rate out of unemployment along with the sanction rate and hazard rate into active labour market programmes. We...

  19. Playing after work? Opportunities and challenges of a physical activity programme for female cleaners

    DEFF Research Database (Denmark)

    Lenneis, Verena; Pfister, Gertrud Ursula

    2016-01-01

    study. In this article we share information about the design and the evaluation of a worksite physical activity programme based on a social ecological approach to health promotion. Via participant observation and semi-structured interviews with 20 cleaners and their five supervisors we explored which...

  20. Utilisation of Wearable Computing for Space Programmes Test Activities Optimasation

    Science.gov (United States)

    Basso, V.; Lazzari, D.; Alemanni, M.

    2004-08-01

    New technologies are assuming a relevant importance in the Space business domain also in the Assembly Integration and Test (AIT) activities allowing process optimization and capability that were unthinkable only few years ago. This paper has the aim to describe Alenia Spazio (ALS) gained experience on the remote interaction techniques as a results of collaborations established both on European Communities (EC) initiatives, with Alenia Aeronautica (ALA) and Politecnico of Torino (POLITO). The H/W and S/W components performances increase and costs reduction due to the home computing massive utilization (especially demanded by the games business) together with the network technology possibility (offered by the web as well as the hi-speed links and the wireless communications) allow today to re-think the traditional AIT process activities in the light of the multimedia data exchange: graphical, voice video and by sure more in the future. Aerospace business confirm its innovation vocation which in the year '80 represents the cradle of the CAD systems and today is oriented to the 3D data visualization/ interaction technologies and remote visualisation/ interaction in collaborative way on a much more user friendly bases (i.e. not for specialists). Fig. 1 collects AIT extended scenario studied and adopted by ALS in these years. ALS experimented two possibilities of remote visualization/interaction: Portable [e.g. Fig.2 Personal Digital Assistant (PDA), Wearable] and walls (e.g.VR-Lab) screens as both 2D/3D visualisation and interaction devices which could support many types of traditional (mainly based on EGSE and PDM/CAD utilisation/reports) company internal AIT applications: 1. design review support 2. facility management 3. storage management 4. personnel training 5. integration sequences definition 6. assembly and test operations follow up 7. documentation review and external access to AIT activities for remote operations (e.g. tele-testing) EGSE Portable Clean room

  1. Biennial activity report of metallurgy programme for 1987 and 1988

    International Nuclear Information System (INIS)

    The research and development (R and D) activities in the field of metallurgy at Indira Gandhi Centre for Atomic Research, Kalpakkam during 1987-1988 are reported in the form of individual summaries arranged under headings : (1) Mechanical Metallurgy Section, (2) Physical Metallurgy Section, (3) Chemical Metallurgy Section, (4) Materials Technology Section, (5) Division for PIE and NDT Development and (6) Quality Engineering Section. A list of publications by the staff scientists working in the field of metallurgy during report period is given in one of the appendices. (author). figs., tabs

  2. Quality Control in Mammography: A Pilot Programme for First Level Activity

    Energy Technology Data Exchange (ETDEWEB)

    Di Maggio, C.; Gambaccini, M.; Gennaro, G.; Indovina, P.L.; Mazzei, F.; Tuffanelli, A

    1998-07-01

    Quality control programmes are the best tools for maintaining optimal performances of mammographic units. Programmes to spread quality control activities have been organised in various countries. This study presents the results of an educational programme having three main objectives: quality assurance promotion, operator training with simple instruments and procedures, and operator training in quality control data analysis. Special kits have been distributed to several mammographic centres. In each centre the kit has been used to execute the following tests: AEC performance, processing conditions, entrance exposure and image quality. The data gathered in 53 centres for a period of 4 weeks are compared and discussed. Several centres were found not to satisfy completely the technical recommendations of the Italian protocol, implying training for radiographers and radiologists in QC procedures is desirable. (author)

  3. Oncogenic programmes and Notch activity: an 'organized crime'?

    Science.gov (United States)

    Dominguez, Maria

    2014-04-01

    The inappropriate Notch signalling can influence virtually all aspect of cancer, including tumour-cell growth, survival, apoptosis, angiogenesis, invasion and metastasis, although it does not do this alone. Hence, elucidating the partners of Notch that are active in cancer is now the focus of much intense research activity. The genetic toolkits available, coupled to the small size and short life of the fruit fly Drosophila melanogaster, makes this an inexpensive and effective animal model, suited to large-scale cancer gene discovery studies. The fly eye is not only a non-vital organ but its stereotyped size and disposition also means it is easy to screen for mutations that cause tumours and metastases and provides ample opportunities to test cancer theories and to unravel unanticipated nexus between Notch and other cancer genes, or to discover unforeseen Notch's partners in cancer. These studies suggest that Notch's oncogenic capacity is brought about not simply by increasing signal strength but through partnerships, whereby oncogenes gain more by cooperating than acting individually, as in a ring 'organized crime'. PMID:24780858

  4. Oncogenic programmes and Notch activity: an 'organized crime'?

    Science.gov (United States)

    Dominguez, Maria

    2014-04-01

    The inappropriate Notch signalling can influence virtually all aspect of cancer, including tumour-cell growth, survival, apoptosis, angiogenesis, invasion and metastasis, although it does not do this alone. Hence, elucidating the partners of Notch that are active in cancer is now the focus of much intense research activity. The genetic toolkits available, coupled to the small size and short life of the fruit fly Drosophila melanogaster, makes this an inexpensive and effective animal model, suited to large-scale cancer gene discovery studies. The fly eye is not only a non-vital organ but its stereotyped size and disposition also means it is easy to screen for mutations that cause tumours and metastases and provides ample opportunities to test cancer theories and to unravel unanticipated nexus between Notch and other cancer genes, or to discover unforeseen Notch's partners in cancer. These studies suggest that Notch's oncogenic capacity is brought about not simply by increasing signal strength but through partnerships, whereby oncogenes gain more by cooperating than acting individually, as in a ring 'organized crime'.

  5. Evaluation of physical activity programmes for the elderly - exploring the lessons from other sectors and examining the general characteristics of the programmes

    Directory of Open Access Journals (Sweden)

    Clara-Santos Paula

    2011-09-01

    Full Text Available Abstract Background In Portugal, there are several physical activity (PA programmes for elderly people developed by the local government. The importance of these programmes has been increasing since the evidence has shown that this type of health promotion interventions may reduce the deleterious effects of the ageing process. However, no study has already identified the general characteristics of these programmes nor if they use any scheme to assess the quality of the service provided. A widely-used scheme is the EFQM Excellence Model, which will be in the core of our present work. Thus, the main aims of this preliminary study were 1 to identify the general characteristics of the PA programmes developed by the Portuguese Local Public Administration 2 to determine the extent of implementation of quality initiatives in these programmes. Methods Data were collected by an on-line questionnaire sent to all Continental Municipalities (n = 278. Categorical data were expressed as absolute counts and percentages. Continuous data were expressed as the mean and SD. An open-ended question was analysed using qualitative content analysis with QSR NVivo software. Associations between categorical variables were tested by the use of contingency tables and the calculation of chi-square tests. Significance level was set at p ≤ 0.05. Results Results showed: i a total of 125 PA programmes were identified in the 18 districts of the Portugal mainland; ii the main goal of the majority (95.2% was the participants' health promotion; iii different characteristics of the programmes were found according to different regions of the country; iv certain characteristics of the programmes were associated to the existence of other features; v only one PA programme developed quality initiatives. Conclusions In conclusion, although there are many PA programmes for elderly people spread throughout the country, aiming at improving the health of participants, the overwhelming

  6. How to implement a balanced programme for musical activities in kindergarten

    OpenAIRE

    Zgonc, Nadja

    2016-01-01

    The preschool and school periods are the most important time for intensive music education. In order to successfully enhance a child’s musical development, nursery teachers should ensure that music activities are equally represented within the programme (singing, playing musical instruments, listening to music, listening to music during creative activities, creating music itself, didactic music games). One of the principles that should be followed by nursery teachers and is set out in the Slo...

  7. 2014 ICSA/KISS Joint Applied Statistics Symposium

    CERN Document Server

    Liu, Mengling; Luo, Xiaolong

    2016-01-01

    The papers in this volume represent the most timely and advanced contributions to the 2014 Joint Applied Statistics Symposium of the International Chinese Statistical Association (ICSA) and the Korean International Statistical Society (KISS), held in Portland, Oregon. The contributions cover new developments in statistical modeling and clinical research: including model development, model checking, and innovative clinical trial design and analysis. Each paper was peer-reviewed by at least two referees and also by an editor. The conference was attended by over 400 participants from academia, industry, and government agencies around the world, including from North America, Asia, and Europe. It offered 3 keynote speeches, 7 short courses, 76 parallel scientific sessions, student paper sessions, and social events. The most timely and advanced contributions from the joint 2014 ICSA/KISS Applied Statistics Symposium All papers feature original, peer-reviewed content Coverage consists of new developments in statisti...

  8. Kissing Bug (Triatoma spp.) Intrusion into Homes: Troublesome Bites and Domiciliation

    OpenAIRE

    Klotz, Stephen A.; F. Mazda Shirazi; Keith Boesen; Beatty, Norman L.; Dorn, Patricia L.; Shannon Smith; Schmidt, Justin O

    2016-01-01

    Kissing bugs (Triatoma spp.) frequently enter homes and bite human and pet occupants. Bites may lead to severe allergic reactions and, in some cases, death. Kissing bugs are also vectors of Trypanosoma cruzi, the cause of Chagas disease. In general, modern houses in the United States are not conducive to domiciliation of kissing bugs (bugs living out their entire life within the home with the presence of eggs, nymphs, adults, and exuviae). Construction features such as concrete foundations, s...

  9. Baastrup’s disease (kissing spines syndrome): a pictorial review

    OpenAIRE

    Dimitrios K. Filippiadis; Mazioti, Argyro; Argentos, S; Anselmetti, G.; Papakonstantinou, O.; Kelekis, N.; Kelekis, Alexis

    2015-01-01

    Abstract Excessive lordosis is a common finding and may produce mechanical pressure that causes repetitive strains of the interspinous ligament with subsequent degeneration and collapse. Baastrup’s disease (kissing spine syndrome) is a term referring to close approximation of adjacent spinous processes due to degenerative changes of the spine. Baastrup’s disease usually affects the lumbar spine, with L4-L5 being the most commonly affected level. There is higher occurrence at ages over 70 and ...

  10. New and recently finalised activities within the NKS Programmes for Nordic cooperation on nuclear reactor safety and emergency preparedness

    DEFF Research Database (Denmark)

    Andgren, Karin; Andersson, Kasper Grann; Magnússon, Sigurður M.;

    2015-01-01

    Over the years, NKS has provided funding for hundreds of research activities in fields comprising reactor safety, decommissioning, nuclear and radiological emergency preparedness, and management of radioactive waste. Advanced technologies and methods developed under the NKS framework have been used...... within the Nordic countries as well as internationally. Two programme areas are defined under the NKS platform: The NKS-R programme on nuclear reactor safety and the NKS-B programme on emergency preparedness. Three articles, giving an introduction to NKS and its two programmes, were published in...

  11. New and recently finalised activities within the NKS Programmes for Nordic cooperation on nuclear reactor safety and emergency preparedness

    DEFF Research Database (Denmark)

    Andgren, Karin; Andersson, Kasper Grann; Magnússon, Sigurður M.;

    2015-01-01

    Over the years, NKS has provided funding for hundreds of research activities in fields comprising reactor safety, decommissioning, nuclear and radiological emergency preparedness, and management of radioactive waste. Advanced technologies and methods developed under the NKS framework have been used...... within the Nordic countries as well as internationally. Two programme areas are defined under the NKS platform: The NKS-R programme on nuclear reactor safety and the NKS-B programme on emergency preparedness. Three articles, giving an introduction to NKS and its two programmes, were published...

  12. Contaminated land rehabilitation - activities, networks and programmes of the European Union; Altlastenaktivitaeten auf europaeischer Ebene

    Energy Technology Data Exchange (ETDEWEB)

    Kasamas, H. [CLARINET Koordinierungsstelle, Wien (Austria)

    2000-07-01

    The paper discusses EU programmes and cooperative projects for soil and groundwater rehabilitation, R and D activities for rehabilitation technology development, and the outcome of programmes and projects when available. (orig./CB) [German] Um den Herausforderungen der Altlastenproblematik in den industrialisierten Laendern noch effektiver zu begegnen, wurde die internationale Zusammenarbeit, vor allem auf europaeischer Ebene, verstaerkt in Angriff genommen. Internationale Initiativen zu diversen altlastenrelevanten Problemstellungen sollen eine koordinierte Vorgangsweise zum Nutzen aller teilnehmenden Laender ermoeglichen. Parallele Anstrengungen in der technischen und wissenschaftlichen Entwicklung sollen vermieden und der Einsatz begrenzt vorhandener Mittel effektiviert werden. Der multinationale Erfahrungsaustausch soll die Wiederholung von weniger zielfuehrenden Entwicklungen in anderen Laendern vermeiden helfen. Dieser Beitrag bietet einen Ueberblick ueber Ziele und Ergebnisse diverser internationaler Initiativen im Altlastenbereich und verweist zu weiterfuehrenden Informationsquellen. (orig.)

  13. Evaluation of Activities in Primary Education Programme with The Teachers’ Views (Sample of Sinop Province

    Directory of Open Access Journals (Sweden)

    Necdet AYKAÇ

    2007-12-01

    Full Text Available This research, aims to investigate the concept of activity on the basis of learning-teaching duration inaccordance with teachers’ views, teachers guide and class materials in the primary education programme put in to practice in 2005- 2006. The research has two subjects. The first one is the quantitative subject aiming to determine the teachers’ views, the second is theoretical subject aiming to analyze the guide books and class metarials. The quantitative research, aiming to determine the teachers’ ideas is consisted of 184 teachers in total in the center and in the central villages of Sinop. The exemplification in this research is occupied by means of 86 teachers applying the teachers’ views determinating scale. In the research as a tool to collect data, determining teachers’ views scale prepared in 5 likert-type scale with 18 articles has been used. Analyzing with SPSS programme, the data gained from the scale has been stated as frequency and percentage. Theoretical dimension examining teachers’ guide and lesson metarials to put the teachers’ views on a objective base, aims to examine teachers guide books and lesson materials analytically and display the base of teachers’ views. It is stated that most of the teachers present their views in that way: They feel themselves insufficent to applythe activities,the physical opportunities of the schools and the facilities are not enough to apply some activities, the classes are crowded, the activities are not student-centered and active teaching methods are not used in the activities.

  14. Clinical Significance of KISS1 Protein Expression for Brain Invasion and Metastasis

    Science.gov (United States)

    Ulasov, Ilya V.; Kaverina, Natalya V.; Pytel, Peter; Thaci, Bart; Liu, FeiFei; Hurst, Douglas R.; Welch, Danny R.; Sattar, Husein A.; Olopade, Olufunmilayo I.; Baryshnikov, Anatoly Y.; Kadagidze, Zaira G.; Lesniak, Maciej S.

    2013-01-01

    BACKGROUND Metastases to the brain represent a feared complication and contribute to the morbidity and mortality of breast cancer. Despite improvements in therapy, prognostic factors for development of metastases are lacking. KISS1 is a metastasis suppressor that demonstrates inhibition of metastases formation in several types of cancer. The purpose of this study was to determine the importance of KISS1 expression in breast cancer progression and the development of intracerebral lesions. METHODS In this study, we performed a comparative analysis of 47 brain metastases and 165 primary breast cancer specimens by using the antihuman KISS1 antibody. To compare KISS1 expression between different groups, we used a 3-tier score and the automated score computer software (ACIS) evaluation. To reveal association between mRNA and protein expression, we used quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analysis. Significance of immunohistochemistry stainings was correlated with clinicopathological data. RESULTS We identified that KISS1 expression is significantly higher in primary breast cancer compared with brain metastases (P < .05). The mRNA analysis performed on 33 selected ductal carcinoma brain metastatic lesions and 36 primary ductal carcinomas revealed a statistically significant down-regulation of KISS1 protein in metastatic cases (P = .04). Finally, we observed a significant correlation between expression of KISS1 and metastasis-free survival (P = .04) along with progression of breast cancer and expression of KISS1 in primary breast cancer specimens (P = .044). CONCLUSIONS In conclusion, our study shows that breast cancer expresses KISS1. Cytoplasmic expression of KISS1 may be used as a prognostic marker for increased risk of breast cancer progression. PMID:21928364

  15. Objects prompt authentic scientific activities among learners in a museum programme

    DEFF Research Database (Denmark)

    Achiam, Marianne; Simony, Leonora; Lindow, Bent Erik Kramer

    2016-01-01

    Although the scientific disciplines conduct practical work in different ways, all consider practical work as the essential way of connecting objects and phenomena with ideas and the abstract. Accordingly, practical work is regarded as central to science education as well. We investigate a practical......, object-based palaeontology programme at a natural history museum to identify how palaeontological objects prompt scientific activity among upper secondary school students. We first construct a theoretical framework based on an analysis of the programme’s palaeontological content. From this, we build our...

  16. Scientific Goals of the Kunlun Infrared Sky Survey (KISS)

    CERN Document Server

    Burton, Michael; Mould, Jeremy; Cooke, Jeff; Ireland, Michael; Uddin, Syed Ashraf; Zhang, Hui; Yuan, Xiangyan; Lawrence, Jon; Ashley, Michael; Wu, Xuefend; Curtin, Chris; Wang, Lifan

    2016-01-01

    The high Antarctic plateau provides exceptional conditions for conducting infrared observations of the cosmos on account of the cold, dry and stable atmosphere above the ice surface. This paper describes the scientific goals behind the first program to examine the time-varying universe in the infrared from Antarctica - the Kunlun Infrared Sky Survey (KISS). This will employ a small (50 cm aperture) telescope to monitor the southern skies in the 2.4um Kdark window from China's Kunlun station at Dome A, on the summit of the Antarctic plateau, through the uninterrupted 4-month period of winter darkness. An earlier paper discussed optimisation of the Kdark filter for the best sensitivity (Li et al 2016). This paper examines the scientific program for KISS. We calculate the sensitivity of the camera for the extrema of observing conditions that will be encountered. We present the parameters for sample surveys that could then be carried out for a range of cadences and sensitivities. We then discuss several science p...

  17. Scientific Goals of the Kunlun Infrared Sky Survey (KISS)

    Science.gov (United States)

    Burton, Michael G.; Zheng, Jessica; Mould, Jeremy; Cooke, Jeff; Ireland, Michael; Uddin, Syed Ashraf; Zhang, Hui; Yuan, Xiangyan; Lawrence, Jon; Ashley, Michael C. B.; Wu, Xuefeng; Curtin, Chris; Wang, Lifan

    2016-09-01

    The high Antarctic plateau provides exceptional conditions for infrared observations on account of the cold, dry and stable atmosphere above the ice surface. This paper describes the scientific goals behind the first program to examine the time-varying universe in the infrared from Antarctica - the Kunlun Infrared Sky Survey (KISS). This will employ a 50cm telescope to monitor the southern skies in the 2.4μmK dark window from China's Kunlun station at Dome A, on the summit of the Antarctic plateau, through the uninterrupted 4-month period of winter darkness. An earlier paper discussed optimisation of the K dark filter for sensitivity (Li et al. 2016). This paper examines the scientific program for KISS. We calculate the sensitivity of the camera for the extrema of observing conditions that will be encountered. We present the parameters for sample surveys that could then be carried out for a range of cadences and sensitivities. We then discuss several science programs that could be conducted with these capabilities, involving star formation, brown dwarfs and hot Jupiters, exoplanets around M dwarfs, the terminal phases of stellar evolution, fast transients, embedded supernova searches, reverberation mapping of AGN, gamma ray bursts and the detection of the cosmic infrared background.

  18. Building Social Capital : A Field Study of the Active, Beautiful and Clean Waters (ABC Waters) Programme in Singapore

    OpenAIRE

    Tovatt, Oliver

    2015-01-01

    This thesis presents a field study examining the effect of the Active, Beautiful and Clean Waters (ABC Waters) Programme in Singapore on social capital. Based on a multi-disciplinary approach and following the theoretical framework of bonding and bridging social capital developed by Robert Putnam and others, three different cases of the ABC Programme were compared, looking particularly at the level of blue-green landscape integration. The three cases comprised the ABC flagship project ‘Bishan...

  19. The Daughter's Disenchantment: Incest as Pedagogy in Fairy Tales and Kathryn Harrison's the Kiss

    Science.gov (United States)

    Marshall, Elizabeth

    2004-01-01

    The Kiss, is described as a controversial memoir about father-daughter incest that disturbed the cultural silence in a "well heeled" home. The emotional and psychological terrain of the daughter's experience is discussed.

  20. Kissing Mars Rocks with the Rover's RATs: An Educational Exercise to Understand Drilling Rocks on Mars

    Science.gov (United States)

    Williams, D. A.; Whelley, P. L.; Bleacher, J. E.; Cave, S. R.; Zabala-Aliberto, V. A.; Zabala, A. A.; Greeley, R.

    2007-03-01

    This abstract discusses an E/PO exercise we created for elementary school children that uses Hershey Kisses and straws to simulate the drilling of different rocks on Mars by the MER Rock Abrasion Tool.

  1. Measuring and Reducing Off-Target Activities of Programmable Nucleases Including CRISPR-Cas9.

    Science.gov (United States)

    Koo, Taeyoung; Lee, Jungjoon; Kim, Jin-Soo

    2015-06-01

    Programmable nucleases, which include zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and RNA-guided engineered nucleases (RGENs) repurposed from the type II clustered, regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) system are now widely used for genome editing in higher eukaryotic cells and whole organisms, revolutionising almost every discipline in biological research, medicine, and biotechnology. All of these nucleases, however, induce off-target mutations at sites homologous in sequence with on-target sites, limiting their utility in many applications including gene or cell therapy. In this review, we compare methods for detecting nuclease off-target mutations. We also review methods for profiling genome-wide off-target effects and discuss how to reduce or avoid off-target mutations.

  2. A quality assurance programme for the determination of selenium in foods by instrumental neutron activation analysis

    International Nuclear Information System (INIS)

    Selenium is unevenly distributed through the biosphere. The levels, species and bioavailability of selenium in foods depend greatly on the geochemical environment in which they are grown. Variation in geochemical conditions can not only lead to certain diseases in animals but also influence the selenium body burden in humans. For these reasons, there is an increasing interest in monitoring selenium levels in foods and diets. A quality assurance programme has been developed for the determination of low levels of selenium in foods and diets by cyclic and pseudo-cyclic instrumental neutron activation analysis (INAA) using the short-lived (half-life = 17.4 s) 77Sem nuclide. Both conventional and anti-coincidence gamma ray spectrometry techniques have been employed. Pseudo-cyclic INAA in conjunction with anti-coincidence counting has been found to provide the most reliable results. Internal and external quality assessments have been done using a number of parameters. (author)

  3. Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins.

    Science.gov (United States)

    Maeder, Morgan L; Angstman, James F; Richardson, Marcy E; Linder, Samantha J; Cascio, Vincent M; Tsai, Shengdar Q; Ho, Quan H; Sander, Jeffry D; Reyon, Deepak; Bernstein, Bradley E; Costello, Joseph F; Wilkinson, Miles F; Joung, J Keith

    2013-12-01

    Genome-wide studies have defined cell type-specific patterns of DNA methylation that are important for regulating gene expression in both normal development and disease. However, determining the functional significance of specific methylation events remains challenging, owing to the lack of methods for removing such modifications in a targeted manner. Here we describe an approach for efficient targeted demethylation of specific CpGs in human cells using fusions of engineered transcription activator-like effector (TALE) repeat arrays and the TET1 hydroxylase catalytic domain. Using these TALE-TET1 fusions, we demonstrate that modification of critical methylated promoter CpG positions can lead to substantial increases in the expression of endogenous human genes. Our results delineate a strategy for understanding the functional significance of specific CpG methylation marks in the context of endogenous gene loci and validate programmable DNA demethylation reagents with potential utility for research and therapeutic applications.

  4. Kissing contusion between the posterolateral tibial plateau and lateral femoral condyle: associated ligament and meniscal tears

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Hyun Pyo; Lee, Jae Gue; Park, Ji Seon; Ryu, Kyung Nam [Kyunghee Univ., Seoul (Korea, Republic of)

    2004-02-01

    Kissing contusion between the posterolateral tibial plateau and lateral femoral condyle is frequently found in association with a tear of the anterior cruciate liagment (ACL). The purpose of this study was to determine which ligamentous and meniscal tears are associated with kissing contusion. We retrospectively reviewed the findings depicted by 323 consecutive MR images of the knee and confirmed at arthroscopy. For the diagnosis of disruption, ligaments, medial menisci (MM) and lateral menisci (LM) were evaluated using accepted criteria. We compared the prevalence and location of meniscal and ligamentous tears between group I (44 knees with kissing contusion) and group II (279 knees without kissing contusion). For statistical analysis the chi-square test was used. ACLs were torn in all 44 knees (100%) with kissing contusion, and 78 (28%) of 279 without kissing contusion. There were ten medial collateral ligament (MCL) tears (23%) in group I, and 17 MCL tears (6%), five lateral collateral ligament (LCL) tears (2%) and ten posterior cruciate ligament (PCL) tears (4%) in group II. In group I, meniscal tears were found in 22 MM (50%) and in 19 LM (43%), while in group II, they occurred in 128 MM (46%) and 128 LM (46%), In group I, 17 (77%) of 22 MM tears and 13 (68%) of 19 LM tears were located in the posterior horn, while in group II, the corresponding figures were 97/128 (76%) and 60 of 128 (47%). The differing prevalence of ACL and MCL tears between the groups was statistically significant (p<0.05), but differences in the prevalence and location of meniscal tears were not (p>0.05). Although kissing contusion was a highly specific sign of ACL tears, its presence was also significant among MCL tears. There was no significant difference in meniscal tears with or without kissing contusion.

  5. The SEDIBUD (Sediment Budgets in Cold Environments) Programme: Current activities and future key tasks

    Science.gov (United States)

    Beylich, A. A.; Lamoureux, S. F.; Decaulne, A.

    2012-04-01

    Projected climate change in cold regions is expected to alter melt season duration and intensity, along with the number of extreme rainfall events, total annual precipitation and the balance between snowfall and rainfall. Similarly, changes to the thermal balance are expected to reduce the extent of permafrost and seasonal ground frost and increase active layer depths. These effects will undoubtedly change surface environments in cold regions and alter the fluxes of sediments, nutrients and solutes, but the absence of quantitative data and coordinated process monitoring and analysis to understand the sensitivity of the Earth surface environment is acute in cold climate environments. The International Association of Geomorphologists (I.A.G./A.I.G.)SEDIBUD (Sediment Budgets in Cold Environments) Programme was formed in 2005 to address this existing key knowledge gap. SEDIBUD currently has about 400 members worldwide and the Steering Committee of this international programme is composed of ten scientists from eight different countries: Achim A. Beylich (Chair) (Norway), Armelle Decaulne (Secretary) (France), John C. Dixon (USA), Scott F. Lamoureux (Vice-Chair) (Canada), John F. Orwin (Canada), Jan-Christoph Otto (Austria), Irina Overeem (USA), Thorsteinn Saemundsson (Iceland), Jeff Warburton (UK), Zbigniew Zwolinski (Poland). The central research question of this global group of scientists is to: Assess and model the contemporary sedimentary fluxes in cold climates, with emphasis on both particulate and dissolved components. Initially formed as European Science Foundation (ESF) Network SEDIFLUX (2004-2006), SEDIBUD has further expanded to a global group of researchers with field research sites located in polar and alpine regions in the northern and southern hemisphere. Research carried out at each of the close to 50 defined SEDIBUD key test sites varies by programme, logistics and available resources, but typically represent interdisciplinary collaborations of

  6. A school-based physical activity program to improve health and fitness in children aged 6–13 years ("Kinder-Sportstudie KISS": study design of a randomized controlled trial [ISRCTN15360785

    Directory of Open Access Journals (Sweden)

    Knöpfli Martin

    2006-06-01

    Full Text Available Abstract Background Childhood obesity is the result of a long lasting imbalance between energy intake and energy expenditure. A major contributing factor is physical inactivity which is closely linked to bone health, cardiovascular disease risk, fitness and psychological factors. The school seems to provide an excellent setting to enhance levels of physical activity (PA. However, there is insufficient data from previous school-based intervention trials on how to enhance overall PA. It is also unknown whether an intervention aimed at increasing PA is effective in improving the children's health. The purpose of this paper is to outline the design of a school-based randomized, controlled trial (RCT aiming to increase overall PA and to improve fitness and health in 6- to 13-year-old children. Methods/Design 15 schools were randomized to the intervention (n = 9 or the control (n = 6 group, stratified by geographic region (urban vs. rural and by age (1st and 5th grade. Participation was given for all children in the intervention group since in this group the intervention was part of the normal school curriculum. The intervention during one academic year consisted of: 1. two additional physical education classes per week given by trained physical education teachers adding up to a total of five PA classes per week, 2. short PA breaks (2–5 min each during academic lessons, 3. PA home work, and 4. adaptation of recreational areas around the school. All children underwent anthropometric measurements, blood pressure assessment, fitness testing, measurement of PA and they filled out questionnaires. At least 70% of all children agreed to blood sampling and measurements of body composition and bone mineral measurements by dual energy x-ray absorptiometry. The primary endpoints of the study after one year were an increase in total PA by accelerometry, an increase in aerobic fitness measured by the 20 m shuttle run, a decrease in percent body fat derived from

  7. A multichannel integrated circuit for electrical recording of neural activity, with independent channel programmability.

    Science.gov (United States)

    Mora Lopez, Carolina; Prodanov, Dimiter; Braeken, Dries; Gligorijevic, Ivan; Eberle, Wolfgang; Bartic, Carmen; Puers, Robert; Gielen, Georges

    2012-04-01

    Since a few decades, micro-fabricated neural probes are being used, together with microelectronic interfaces, to get more insight in the activity of neuronal networks. The need for higher temporal and spatial recording resolutions imposes new challenges on the design of integrated neural interfaces with respect to power consumption, data handling and versatility. In this paper, we present an integrated acquisition system for in vitro and in vivo recording of neural activity. The ASIC consists of 16 low-noise, fully-differential input channels with independent programmability of its amplification (from 100 to 6000 V/V) and filtering (1-6000 Hz range) capabilities. Each channel is AC-coupled and implements a fourth-order band-pass filter in order to steeply attenuate out-of-band noise and DC input offsets. The system achieves an input-referred noise density of 37 nV/√Hz, a NEF of 5.1, a CMRR > 60 dB, a THD < 1% and a sampling rate of 30 kS/s per channel, while consuming a maximum of 70 μA per channel from a single 3.3 V. The ASIC was implemented in a 0.35 μm CMOS technology and has a total area of 5.6 × 4.5 mm². The recording system was successfully validated in in vitro and in vivo experiments, achieving simultaneous multichannel recordings of cell activity with satisfactory signal-to-noise ratios.

  8. Observation of gonad at different development stages and expression analysis of Kiss2/Kiss2r genes in Megalobrama amblycephala%团头鲂性腺发育不同时期组织学观察及Kiss2/Kiss2r基因表达分析

    Institute of Scientific and Technical Information of China (English)

    温久福; 高泽霞; 罗伟; 童金苟; 王卫民

    2013-01-01

    Lots of studies have proved that Kiss gene and its receptor gene Kissr play an important role in the regulation of the gonadotropic axis,especially in the timing of puberty in vertebrates.We identified the gonad development of blunt snout bream (Megalobrama amblycephala) from stage Ⅰ to stage Ⅵ using tissue slice technology,detected the Kiss2 and Kiss2r gene transcription in the brain through quantitative real time PCR (qPCR),and collected pituitary and gonad tissues of the samples during different stages.The qPCR results show that Kiss2/Kiss2r play roles in the onset of puberty in M.amblycephala by increasing the expression of pituitary and gonad during ovary development in stage Ⅱ,and the expression of testis in stage Ⅲ.%Kiss基因(Kisspeptin)及其受体Kissr基因(Kiss receptor)组成的系统参与下丘脑-垂体-性腺轴功能的调节,在脊椎动物青春期启动的过程中发挥重要作用.该研究通过组织切片技术观察了团头鲂(Megalobrama amblycephala)卵巢和精巢的不同分期,进一步采用荧光定量PCR技术分析比较了团头鲂Kiss2和Kiss2r基因在雌、雄性腺不同时期对应的脑、垂体、性腺组织中的表达量.组织切片观察明确鉴别出团头鲂卵巢和精巢发育Ⅰ期至Ⅵ期的性腺组织结构,基因荧光定量PCR分析结果表明Kiss2/ Kiss2r系统主要是通过增加团头鲂卵巢发育Ⅱ期时脑和垂体的表达量以及Ⅲ期精巢的表达量来发挥生殖启动作用.

  9. Indian Solar Cities Programme: An Overview of Major Activities and Accomplishments; Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Kandt, A.

    2012-05-01

    This paper details the Indian Solar City Programme, provides an overview of one city's Master Plan and implementation progress, describes NREL's support of the Indian Solar City Programme, and outlines synergies and differences between the Indian and American programs including unique challenges and opportunities India is facing.

  10. A cluster-randomised controlled trial of a physical activity and nutrition programme in retirement villages: a study protocol

    OpenAIRE

    Holt, Anne-Marie; Jancey, Jonine; Lee, Andy H; Kerr, Deborah A; Hills, Andrew P; Anderson, Annie S; Peter A Howat

    2014-01-01

    Introduction Physical activity levels of Australia's ageing population are declining and coincidentally rates of overweight and obesity are increasing. Adequate levels of physical activity and a healthy diet are recognised as important lifestyle factors for the maintenance of a healthy weight and prevention of chronic diseases. Retirement village (RV) residents rarely engage in physical activity and nutrition programmes offered, with poor attendance and low use of existing facilities such as ...

  11. Senior expert group for the review of the Agency's programme of activities. Opening remarks by the Director General

    International Nuclear Information System (INIS)

    The document reproduces the opening remarks made by the Director General of the IAEA on 23 March 1998 at the first meeting of the Senior Expert Group for the review of the Agency's programme and activities. The Director General explains his considerations in establishing the group, and the major challenges facing the safe use of nuclear energy and technologies

  12. Short- and long-term effects of a physical activity counselling programme in COPD : A randomized controlled trial

    NARCIS (Netherlands)

    Altenburg, Wytske A.; ten Hacken, Nick H. T.; Bossenbroek, Linda; Kerstjens, Huib A. M.; de Greef, Mathieu H.G.; Wempe, Johan B.

    2015-01-01

    Background: We were interested in the effects of a physical activity (PA) counselling programme in three groups of COPD patients from general practice (primary care), outpatient clinic (secondary care) and pulmonary rehabilitation (PR). Methods: In this randomized controlled trial 155 COPD patients,

  13. Active optics null test system based on a liquid crystal programmable spatial light modulator.

    Science.gov (United States)

    Ares, Miguel; Royo, Santiago; Sergievskaya, Irina; Riu, Jordi

    2010-11-10

    We present an active null test system adapted to test lenses and wavefronts with complex shapes and strong local deformations. This system provides greater flexibility than conventional static null tests that match only a precisely positioned, individual wavefront. The system is based on a cylindrical Shack-Hartmann wavefront sensor, a commercial liquid crystal programmable phase modulator (PPM), which acts as the active null corrector, enabling the compensation of large strokes with high fidelity in a single iteration, and a spatial filter to remove unmodulated light when steep phase changes are compensated. We have evaluated the PPM's phase response at 635 nm and checked its performance by measuring its capability to generate different amounts of defocus aberration, finding root mean squared errors below λ/18 for spherical wavefronts with peak-to-valley heights of up to 78.7λ, which stands as the limit from which diffractive artifacts created by the PPM have been found to be critical under no spatial filtering. Results of a null test for a complex lens (an ophthalmic customized progressive addition lens) are presented and discussed. PMID:21068848

  14. Active optics null test system based on a liquid crystal programmable spatial light modulator

    Energy Technology Data Exchange (ETDEWEB)

    Ares, Miguel; Royo, Santiago; Sergievskaya, Irina; Riu, Jordi

    2010-11-10

    We present an active null test system adapted to test lenses and wavefronts with complex shapes and strong local deformations. This system provides greater flexibility than conventional static null tests that match only a precisely positioned, individual wavefront. The system is based on a cylindrical Shack-Hartmann wavefront sensor, a commercial liquid crystal programmable phase modulator (PPM), which acts as the active null corrector, enabling the compensation of large strokes with high fidelity in a single iteration, and a spatial filter to remove unmodulated light when steep phase changes are compensated. We have evaluated the PPM's phase response at 635 nm and checked its performance by measuring its capability to generate different amounts of defocus aberration, finding root mean squared errors below {lambda}/18 for spherical wavefronts with peak-to-valley heights of up to 78.7{lambda}, which stands as the limit from which diffractive artifacts created by the PPM have been found to be critical under no spatial filtering. Results of a null test for a complex lens (an ophthalmic customized progressive addition lens) are presented and discussed.

  15. Programme wood/energy 2000-2006. Activity Report for 2000-2004

    International Nuclear Information System (INIS)

    When ADEME launched its Wood fuel programme throughout all of France in late 1999, its aim was to guide this resource supply chain to maturity and stable development in all user sectors: domestic, multi-family housing, commercial/institutional and industrial applications. To this end the Wood fuel Programme 2000-2006 was assigned objectives and endowed with significant financial means for studies and coordination in order to support and carry out general-interest projects, piloted by ADEME. The stated goal was to replace fossil fuels, avoid carbon emissions and establish quality assurance standards for household firewood and wood-fired devices. This report makes a status of ADEME's Wood fuel programme for the 2000-2004 era: - Domestic heating: After a drop during the 1990's, figures since 1999 of sales of wood-fuel domestic heating equipment (closed heaters, glass-door fires and stoves) have shown a significant rise. On average over 30 years, wood consumption has risen to 7.2 million TOE (40 million cubic metres) per year; - Industry: It is thought there are 1000 wood-fired heaters (above 1 megawatt) used in French industry. These are found mainly in timber-based industries and in timber crushing plants. This amounts to a total power output of 2.5 gigawatts. In the primary and secondary wood processing industries, the increase in the number of wood-fired boilers and energy produced has reached 5% per year Results of a call for carbon energy projects (APEC) was 61 submitted of which 52 were selected; 9 projects pending (166.5 K of aid from ADEME); and 35 projects begun (1,649 K of aid from ADEME). - Local authority and service sector wood-fired heating systems: At the end of 2004, the number of local authority active boilers was 641, producing 430 megawatts. This is an increase of an average of 13% year on year since 2000. By the end of 2004, the target had already been met for the number of boilers being financed (1,090). By 2006 however we still need to generate a

  16. Care of older people in nursing homes: an Intensive Programme as an educational activity within Erasmus-Socrates.

    Science.gov (United States)

    Kotzabassaki, Stella; Alabaster, Erica S; And, Kati; Larsson, Ulla; de Vree, Willem

    2003-02-01

    The paper describes and discusses an Intensive Programme as a European educational activity within Erasmus-Socrates. As nurses and European citizens, it is important to know and understand each other's culture and to be able to work within a united Europe. Education plays a leading role in the preparation of professionals who will have to develop these skills. Based on the aims of Erasmus-Socrates, an Intensive Programme entitled 'Care of Older People in Nursing Homes' was designed, sponsored, and implemented over three continuous academic years with the participation of five European countries. The topic was selected due to its importance for Europe, as it is a region with an ageing population. A wide range of themes was covered using lectures, group discussion, exercises and study visits as teaching strategies. Evaluation suggests that the aims of the programme were achieved.

  17. Technology Programme

    Energy Technology Data Exchange (ETDEWEB)

    Batistoni, Paola; De Marco, Francesco; Pieroni, Leonardo (ed.)

    2005-07-01

    The technology activities carried out by the Euratom-ENEA Association in the framework of the European Fusion Development Agreement concern the Next Step (International Thermonuclear Experimental Reactor - ITER), the Long-Term Programme (breeder blanket, materials, International Fusion Materials Irradiation Facility - IFMIF), Power Plant Conceptual Studies and Socio-Economic Studies. The Underlying Technology Programme was set up to complement the fusion activities as well to develop technologies with a wider range of interest. The Technology Programme mainly involves staff from the Frascati laboratories of the Fusion Technical and Scientific Unit and from the Brasimone laboratories of the Advanced Physics Technologies Unit. Other ENEA units also provide valuable contributions to the programme. ENEA is heavily engaged in component development/testing and in design and safety activities for the European Fusion Technology Programme. Although the work documented in the following covers a large range of topics that differ considerably because they concern the development of extremely complex systems, the high level of integration and coordination ensures the capability to cover the fusion system as a whole. In 2004 the most significant testing activities concerned the ITER primary beryllium-coated first wall. In the field of high-heat-flux components, an important achievement was the qualification of the process for depositing a copper liner on carbon fibre composite (CFC) hollow tiles. This new process, pre-brazed casting (PBC), allows the hot radial pressing (HRP) joining procedure to be used also for CFC-based armour monoblock divertor components. The PBC and HRP processes are candidates for the construction of the ITER divertor. In the materials field an important milestone was the commissioning of a new facility for chemical vapour infiltration/deposition, used for optimising silicon carbide composite (SiCf/SiC) components. Eight patents were deposited during 2004

  18. Ecological patterns of blood-feeding by kissing-bugs (Hemiptera: Reduviidae: Triatominae

    Directory of Open Access Journals (Sweden)

    Jorge Eduardo Rabinovich

    2011-06-01

    Full Text Available Host use by vectors is important in understanding the transmission of zoonotic diseases, which can affect humans, wildlife and domestic animals. Here, a synthesis of host exploitation patterns by kissing-bugs, vectors of Chagas disease, is presented. For this synthesis, an extensive literature review restricted to feeding sources analysed by precipitin tests was conducted. Modern tools from community ecology and multivariate statistics were used to determine patterns of segregation in host use. Rather than innate preferences for host species, host use by kissing-bugs is influenced by the habitats they colonise. One of the major limitations of studies on kissing-bug foraging has been the exclusive focus on the dominant vector species. We propose that expanding foraging studies to consider the community of vectors will substantially increase the understanding of Chagas disease transmission ecology. Our results indicate that host accessibility is a major factor that shapes the blood-foraging patterns of kissing-bugs. Therefore, from an applied perspective, measures that are directed at disrupting the contact between humans and kissing-bugs, such as housing improvement, are among the most desirable strategies for Chagas disease control.

  19. A kissing loop is important for btuB riboswitch ligand sensing and regulatory control.

    Science.gov (United States)

    Lussier, Antony; Bastet, Laurène; Chauvier, Adrien; Lafontaine, Daniel A

    2015-10-30

    RNA-based genetic regulation is exemplified by metabolite-binding riboswitches that modulate gene expression through conformational changes. Crystal structures show that the Escherichia coli btuB riboswitch contains a kissing loop interaction that is in close proximity to the bound ligand. To analyze the role of the kissing loop interaction in the riboswitch regulatory mechanism, we used RNase H cleavage assays to probe the structure of nascent riboswitch transcripts produced by the E. coli RNA polymerase. By monitoring the folding of the aptamer, kissing loop, and riboswitch expression platform, we established the conformation of each structural component in the absence or presence of bound adenosylcobalamin. We found that the kissing loop interaction is not essential for ligand binding. However, we showed that kissing loop formation improves ligand binding efficiency and is required to couple ligand binding to the riboswitch conformational changes involved in regulating gene expression. These results support a mechanism by which the btuB riboswitch modulates the formation of a tertiary structure to perform metabolite sensing and regulate gene expression. PMID:26370077

  20. National Report Germany: Sounding Rocket and Balloon Research Activities Supported by the German Space Programme in 2013-2015

    Science.gov (United States)

    Kuhl, R.; Gritzner, C.; Friedrichs, D.

    2015-09-01

    Mainly sounding rockets but also stratospheric balloons have played a crucial role in implementing the German Space Programme since many years. Research activities were conducted in the fields of Microgravity Research, Space Science, Earth Observation, Space Technology Development, and Education. Currently, the mesosphere and ionosphere of the Earth and the photosphere and chromosphere of the Sun are in the focus of German research activities in the field of Space Science. Microgravity related topics are studied in the disciplines of Life and Physical Sciences during ballistic TEXUS and MAPHEUS rocket flights. A lot of student activities are currently supported by the agencies SNSB and DLR under the auspices of the Swedish-German programme REXUS/BEXUS.

  1. The Impact of Adventure Based Activity at Malaysian National Service Training Programme on Team Cohesion: A Demographic Analysis.

    Directory of Open Access Journals (Sweden)

    Jaffry Zakaria

    2012-12-01

    Full Text Available The present study examines the effects of physical module elements (adventure based activity included in the Malaysian National Service Programme and to investigate the socio-demographic variables impact on team cohesion building among the participants. In this study, the participants were selected from three different camps, namely, Tasoh camp, Guar Chenderai camp and Meranti camp, located in the state of Perlis, Malaysia. The participants were those from the second batch intake in the year 2007. The sample sizes comprised of 994 participants (480=males, 514=females. The present study applied a pre-test and post-test design. The group was tested before and after the programme. This design was chosen because it could measure the impacts of the adventure-based activity towards team cohesion over time through the pre- and post-test scores (Berg & Latin, 2004. The variables comprised of the demographic factors (age, gender and place of residence, which included team cohesion were measured by Group Environmental Questionnaire (GEQ (Carron, Widmeyer, & Brawley, 1985. Results indicated that the participants of the National Service Training Programme underwent group cohesion change during the Physical Module activities (adventure based activities that were carried out at the camp. The changes were observable based on the statistically analyzed data during the pre and post-test.

  2. An Analysis of Theme in Crista Faust’s Novel Supernatural: Coyote's Kiss

    OpenAIRE

    Viryanza, Ryan Rosta

    2015-01-01

    Literature is the art of written work. And the novel is one of the literary work and the three important branches of literature: novel, poetry, and drama. Novel contains an interesting story and moral message for the readers. The paper entitled “An Analysis of Theme in Christa Faust’s Novel Supernatural: Coyote's Kiss is about the theme elements in a literary work consist of main-theme, sub-theme, and the analogy of the novel to real life. Supernatural: Coyote's kiss is a novel by Christa Fau...

  3. The Impact of Adventure Based Activity at Malaysian National Service Training Programme on Team Cohesion: A Demographic Analysis.

    OpenAIRE

    Jaffry Zakaria; Mazuki Mohd Yasim; Md Amin Md Taff

    2012-01-01

    The present study examines the effects of physical module elements (adventure based activity) included in the Malaysian National Service Programme and to investigate the socio-demographic variables impact on team cohesion building among the participants. In this study, the participants were selected from three different camps, namely, Tasoh camp, Guar Chenderai camp and Meranti camp, located in the state of Perlis, Malaysia. The participants were those from the second batch intake in the yea...

  4. Indian Solar Cities Programme: An Overview of Major Activities and Accomplishments (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Kandt, A.

    2012-05-01

    Indian Solar Cities Programme supports 60 Indian cities in the development of EE and RE projects. Aims to reduce conventional energy demand by 10% by 2013, compared to a baseline year of 2008, and support is provided to municipal corporations for preparing and implementing a master plan.

  5. Active surveillance and control programme for Salmonella Dublin in Cattle

    DEFF Research Database (Denmark)

    Nielsen, Liza Rosenbaum; Rattenborg, Erik

    2011-01-01

    -positive. This suggests that there might be synergistic benefits from running control programmes for both infections simultaneously. We did not find the risk of becoming test-positive significantly different between organic and conventional herds, nor between analysing laboratories. Even when controlling for other risk...

  6. THE KISSING NUMBER OF THE REGULAR PENTAGON%正五边形的吻合数

    Institute of Scientific and Technical Information of China (English)

    赵立宽

    2001-01-01

    设Pn是任意一个正n边形,k(Pn)表示Pn的吻合数,该文证明了k(P5)=6.%Let Pn be an arbitrary regular polygon containing n sides and k(Pn) its kissing number, then k(P5)=6 is obtained.

  7. Protocol of a longitudinal cohort study on physical activity behaviour in physically disabled patients participating in a rehabilitation counselling programme: ReSpAct

    Science.gov (United States)

    Alingh, Rolinde A; Hoekstra, Femke; van der Schans, Cees P; Hettinga, Florentina J; Dekker, Rienk; van der Woude, Lucas H V

    2015-01-01

    Introduction Stimulating physical activity behaviour in persons with a physical disability is important, especially after discharge from rehabilitation. A tailored counselling programme covering both the period of the rehabilitation treatment and the first months at home seems on the average effective. However, a considerable variation in response is observed in the sense that some patients show a relevant beneficial response while others show no or only a small response on physical activity behaviour. The Rehabilitation, Sports and Active lifestyle (ReSpAct) study aims to estimate the associations of patient and programme characteristics with patients’ physical activity behaviour after their participation in a tailored counselling programme. Methods and analysis A questionnaire-based nationwide longitudinal prospective cohort study is conducted. Participants are recruited from 18 rehabilitation centres and hospitals in The Netherlands. 2000 participants with a physical disability or chronic disease will be followed during and after their participation in a tailored counselling programme. Programme outcomes on physical activity behaviour and patient as well as programme characteristics that may be associated with differences in physical activity behaviour after programme completion are being assessed. Data collection takes place at baseline and 14, 33 and 52 weeks after discharge from rehabilitation. Ethics and dissemination The study protocol has been approved by the Medical Ethics Committee of the University Medical Centre Groningen and at individual participating institutions. All participants give written informed consent. The study results will provide new insights into factors that may help explain the differences in physical activity behaviour of patients with a physical disability after they have participated in the same physical activity and sports stimulation programme. Thereby, it will support healthcare professionals to tailor their guidance and

  8. REVIEW OF THE NATIONAL RESTOCKING PROGRAMMEACTIVE PROTECTION OF NATIVE CRAYFISH IN POLAND” 1999-2001

    Directory of Open Access Journals (Sweden)

    ŠMIETANA P.

    2004-01-01

    Full Text Available After the first spread of crayfish plague (aphanomycosis at the end of the nineteenth century, the formerly abundant populations of native crayfish in Poland declined drastically. Analysis of historical data on the occurrence and distribution of crayfish in Poland led to the conclusion that without human intervention the native crayfish species would be at high risk of being made extinct. The largest programme concerning crayfish monitoring and restocking in Poland was “Active protection of native crayfish in Poland” conducted by the Inland Fisheries Institute, the Department of Ecology, University of Szczecin, the Department of Zoology, Warsaw Agricultural University and the University of Warmia and Mazury that was funded by the EkoFundusz Foundation and Inland Fisheries Institute in 1999-2001. One of the main objectives and results of this programme was the determination of indigenous crayfish distribution in Poland (mainly Astacus astacus and Astacus leptodactylus and the restocking of suitable habitats with indigenous crayfish. The densest populations (> 2 500 adult individuals per hectare were used as a source of restocking material. Restocking was performed in 54 water bodies using a total of 45 200 individuals of A. astacus and 9 800 of A. leptodactylus. Between 2001-2002, the success of the restocking programme was monitored. According to the results obtained so far, the restocking exercise has been successful in at least 60.8% of the cases.

  9. A “Timed” Kiss Is Essential for Reproduction: Lessons from Mammalian Studies

    Science.gov (United States)

    Putteeraj, Manish; Soga, Tomoko; Ubuka, Takayoshi; Parhar, Ishwar S.

    2016-01-01

    Reproduction is associated with the circadian system, primarily as a result of the connectivity between the biological clock in the suprachiasmatic nucleus (SCN) and reproduction-regulating brain regions, such as preoptic area (POA), anteroventral periventricular nucleus (AVPV), and arcuate nucleus (ARC). Networking of the central pacemaker to these hypothalamic brain regions is partly represented by close fiber appositions to specialized neurons, such as kisspeptin and gonadotropin-releasing hormone (GnRH) neurons; accounting for rhythmic release of gonadotropins and sex steroids. Numerous studies have attempted to dissect the neurochemical properties of GnRH neurons, which possess intrinsic oscillatory features through the presence of clock genes to regulate the pulsatile and circadian secretion. However, less attention has been given to kisspeptin, the upstream regulator of GnRH and a potent mediator of reproductive functions including puberty. Kisspeptin exerts its stimulatory effects on GnRH secretion via its cognate Kiss-1R receptor that is co-expressed on GnRH neurons. Emerging studies have found that kisspeptin neurons oscillate on a circadian basis and that these neurons also express clock genes that are thought to regulate its rhythmic activities. Based on the fiber networks between the SCN and reproductive nuclei such as the POA, AVPV, and ARC, it is suggested that interactions among the central biological clock and reproductive neurons ensure optimal reproductive functionality. Within this neuronal circuitry, kisspeptin neuronal system is likely to “time” reproduction in a long term during development and aging, in a medium term to regulate circadian or estrus cycle, and in a short term to regulate pulsatile GnRH secretion. PMID:27630616

  10. A "Timed" Kiss Is Essential for Reproduction: Lessons from Mammalian Studies.

    Science.gov (United States)

    Putteeraj, Manish; Soga, Tomoko; Ubuka, Takayoshi; Parhar, Ishwar S

    2016-01-01

    Reproduction is associated with the circadian system, primarily as a result of the connectivity between the biological clock in the suprachiasmatic nucleus (SCN) and reproduction-regulating brain regions, such as preoptic area (POA), anteroventral periventricular nucleus (AVPV), and arcuate nucleus (ARC). Networking of the central pacemaker to these hypothalamic brain regions is partly represented by close fiber appositions to specialized neurons, such as kisspeptin and gonadotropin-releasing hormone (GnRH) neurons; accounting for rhythmic release of gonadotropins and sex steroids. Numerous studies have attempted to dissect the neurochemical properties of GnRH neurons, which possess intrinsic oscillatory features through the presence of clock genes to regulate the pulsatile and circadian secretion. However, less attention has been given to kisspeptin, the upstream regulator of GnRH and a potent mediator of reproductive functions including puberty. Kisspeptin exerts its stimulatory effects on GnRH secretion via its cognate Kiss-1R receptor that is co-expressed on GnRH neurons. Emerging studies have found that kisspeptin neurons oscillate on a circadian basis and that these neurons also express clock genes that are thought to regulate its rhythmic activities. Based on the fiber networks between the SCN and reproductive nuclei such as the POA, AVPV, and ARC, it is suggested that interactions among the central biological clock and reproductive neurons ensure optimal reproductive functionality. Within this neuronal circuitry, kisspeptin neuronal system is likely to "time" reproduction in a long term during development and aging, in a medium term to regulate circadian or estrus cycle, and in a short term to regulate pulsatile GnRH secretion. PMID:27630616

  11. Field programmable gate array based data digitisation with commercial elements

    International Nuclear Information System (INIS)

    One of the most important aspects of particle identification experiments is the digitisation of time, amplitude and charge data from detectors. These conversions are done mostly with Application Specific ICs (ASICs). However, the recent developments in Field Programmable Gate Array (FPGA) technology allow us to use commercial electronic components for the required Front-End Electronics (FEE) and do the digitisation in the FPGA. It is possible to do Time-of-Flight (ToF), Time-over-Threshold (ToT), amplitude and charge measurements with converters implemented in FPGA. We call this principle COME and KISS: Use COMplex COMmercial Elements and Keep It Small and Simple.

  12. The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent

    Directory of Open Access Journals (Sweden)

    Sutcliffe Margaret

    2011-04-01

    Full Text Available Abstract Background Humans and mice with loss of function mutations in GPR54 (KISS1R or kisspeptin do not progress through puberty, caused by a failure to release GnRH. The transcriptional networks regulated by these proteins in the hypothalamus have yet to be explored by genome-wide methods. Results We show here, using 1 million exon mouse arrays (Exon 1.0 Affymetrix and quantitative polymerase chain reaction (QPCR validation to analyse microdissected hypothalamic tissue from Gpr54 and Kiss1 knockout mice, the extent of transcriptional regulation in the hypothalamus. The sensitivity to detect important transcript differences in microdissected RNA was confirmed by the observation of counter-regulation of Kiss1 expression in Gpr54 knockouts and confirmed by immunohistochemistry (IHC. Since Gpr54 and Kiss1 knockout animals are effectively pre-pubertal with low testosterone (T levels, we also determined which of the validated transcripts were T-responsive and which varied according to genotype alone. We observed four types of transcriptional regulation (i genotype only dependent regulation, (ii T only dependent regulation, (iii genotype and T-dependent regulation with interaction between these variables, (iv genotype and T-dependent regulation with no interaction between these variables. The results implicate for the first time several transcription factors (e.g. Npas4, Esr2, proteases (Klk1b22, and the orphan 10-transmembrane transporter TMEM144 in the biology of GPR54/kisspeptin function in the hypothalamus. We show for the neuronal activity regulated transcription factor NPAS4, that distinct protein over-expression is seen in the hypothalamus and hippocampus in Gpr54 knockout mice. This links for the first time the hypothalamic-gonadal axis with this important regulator of inhibitory synapse formation. Similarly we confirm TMEM144 up-regulation in the hypothalamus by RNA in situ hybridization and western blot. Conclusions Taken together, global

  13. Finnish bioenergy research programme

    Energy Technology Data Exchange (ETDEWEB)

    Asplund, D. [VTT Energy, Jyvaeskylae (Finland)

    1996-12-31

    Finland is a leading country in the use of biofuels and has excellent opportunities to increase the use of biofuels by up to 25-30 %. The Finnish Government has set an objective for the promotion of bioenergy. The aim is to increase the use of bioenergy by about 25 % from the present level by 2005, and the increment corresponds to 1.5 million tonnes of oil equivalent (toe) per year. The R and D work has been considered as an important factor to achieve this ambitious goal. Energy research was organised into a series of research programmes in 1988 in accordance with the proposal of Finnish Energy Research Committee. The object of the research programmes is to enhance research activities and to bundle individual projects together into larger research packages. The common target of the Finnish energy research programmes is to proceed from basic and applied research to product development and pilot operation, and after that to the first commercial applications, e.g. demonstrations. As the organisation of energy research to programmes has led to good results, the Finnish Ministry of Trade and Industry decided to go on with this practice by launching new six-year programmes in 1993-1998. One of these programmes is the Bioenergy Research Programme and the co-ordination of this programme is carried out by VTT Energy. Besides VTT Energy the Finnish Forest Research Institute, Work Efficiency Institute, Metsaeteho and University of Joensuu are participating in the programme 7 refs.

  14. The special programme of research in human reproduction: forty years of activities to achieve reproductive health for all.

    Science.gov (United States)

    Benagiano, Giuseppe; d'Arcangues, Catherine; Harris Requejo, Jennifer; Schafer, Alessandra; Say, Lale; Merialdi, Mario

    2012-01-01

    The Special Programme of Research in Human Reproduction (HRP), co-sponsored by the UNDP, UNFPA, WHO, and the World Bank, is celebrating 40 years of activities with an expansion of its mandate and new co-sponsors. When it began, in 1972, the main focus was on evaluating the acceptability, effectiveness, and safety of existing fertility-regulating methods, as well as developing new, improved modalities for family planning. In 1994, HRP not only made major contributions to the Plan of Action of the International Conference on Population and Development (ICPD); it also broadened its scope of work to include other aspects of health dealing with sexuality and reproduction, adding a specific perspective on gender issues and human rights. In 2002, HRP's mandate was once again broadened to include sexually transmitted infections and HIV/AIDS and in 2003 it was further expanded to research activities on preventing violence against women and its many dire health consequences. Today, the work of the Programme includes research on: the sexual and reproductive health of adolescents, women, and men; maternal and perinatal health; reproductive tract and sexually transmitted infections (including HIV/AIDS); family planning; infertility; unsafe abortion; sexual health; screening for cancer of the cervix in developing countries, and gender and reproductive rights. Additional activities by the Programme have included: fostering international cooperation in the field of human reproduction; the elaboration of WHO's first Global Reproductive Health Strategy; work leading to the inclusion of ICPD's goal 'reproductive health for all by 2015' into the Millennium Development Goal framework; the promotion of critical interagency statements on the public health, legal, and human rights implications of female genital mutilation and gender-biased sex selection. Finally, HRP has been involved in the creation of guidelines and tools, such as the 'Medical eligibility criteria for contraceptive use

  15. Research programme 'Active Solar Energy Use - Solar Heating and Heat Storage'. Activities and projects 2003; Programme 'Solaire actif - Chaleur et Stockage de chaleur'. Activites et projets en 2003

    Energy Technology Data Exchange (ETDEWEB)

    Hadorn, J.-C. [Base Consultants, Geneva (Switzerland); Renaud, P. [Planair SA, La Sagne (Switzerland)

    2003-07-01

    In this report by the research, development and demonstration (RD+D) programme coordinators the objectives, activities and main results in the area of solar heating and heat storage in Switzerland are presented for 2003. In a stagnating market environment the strategy of the Swiss Federal Office of Energy mainly consists in improving the quality and durability of solar collectors and materials, optimizing combisystems for space heating and domestic hot water preparation, searching for storage systems with a higher energy storage density than in the case of sensible heat storage in water, developing coloured solar collectors for more architectonic freedom, and finalizing a seasonal heat storage project for 100 dwellings to demonstrate the feasibility of solar fractions larger than 50% in apartment houses. Support was granted to the Swiss Testing Facility SPF in Rapperswil as in previous years; SPF was the first European testing institute to perform solar collector labeling according to the new rules of the 'Solar Keymark', introduced in cooperation with the European Committee for Standardization CEN. Several 2003 projects were conducted within the framework of the Solar Heating and Cooling Programme of the International Energy Agency IEA. Computerized simulation tools were improved. With the aim of jointly producing high-temperature heat and electric power a solar installation including a concentrating collector and a thermodynamic machine based on a Rankine cycle is still being developed. Seasonal underground heat storage was studied in detail by means of a validated computer simulation programme. Design guidelines were obtained for such a storage used in the summer time for cooling and in the winter time for space heating via a heat pump: depending on the ratio 'summer cooling / winter heating', cooling requires a cooling machine, or direct cooling without such a machine is possible. The report ends up with the list of all supported RD

  16. Efficacy of a compulsory homework programme for increasing physical activity and healthy eating in children: the healthy homework pilot study

    Directory of Open Access Journals (Sweden)

    Duncan Scott

    2011-11-01

    Full Text Available Abstract Background Most physical activity and nutrition interventions in children focus on the school setting; however, evidence suggests that children are less active and have greater access to unhealthy food at home. The aim of this pilot study was to examine the efficacy of a compulsory homework programme for increasing physical activity and healthy eating in children. Methods The six-week 'Healthy Homework' programme and complementary teaching resource was developed under the guidance of an intersectoral steering group. Eight senior classes (year levels 5-6 from two diverse Auckland primary schools were randomly assigned into intervention and control groups. A total of 97 children (57 intervention, 40 control aged 9-11 years participated in the evaluation of the intervention. Daily step counts were monitored immediately before and after the intervention using sealed multiday memory pedometers. Screen time, sports participation, active transport to and from school, and the consumption of fruits, vegetables, unhealthy foods and drinks were recorded concurrently in a 4-day food and activity diary. Results Healthy Homework resulted in a significant intervention effect of 2,830 steps.day-1 (95% CI: 560, 5,300, P = 0.013. This effect was consistent between sexes, schools, and day types (weekdays and weekend days. In addition, significant intervention effects were observed for vegetable consumption (0.83 servings.day-1, 95% CI: 0.24, 1.43, P = 0.007 and unhealthy food consumption (-0.56 servings.day-1, 95% CI: -1.05, -0.07, P = 0.027 on weekends but not weekdays, with no interactions with sex or school. Effects for all other variables were not statistically significant regardless of day type. Conclusions Compulsory health-related homework appears to be an effective approach for increasing physical activity and improving vegetable and unhealthy food consumption in children. Further research in a larger study is required to confirm these initial

  17. Genome-scale definition of the transcriptional programme associated with compromised PU.1 activity in acute myeloid leukaemia.

    Science.gov (United States)

    Sive, J I; Basilico, S; Hannah, R; Kinston, S J; Calero-Nieto, F J; Göttgens, B

    2016-01-01

    Transcriptional dysregulation is associated with haematological malignancy. Although mutations of the key haematopoietic transcription factor PU.1 are rare in human acute myeloid leukaemia (AML), they are common in murine models of radiation-induced AML, and PU.1 downregulation and/or dysfunction has been described in human AML patients carrying the fusion oncogenes RUNX1-ETO and PML-RARA. To study the transcriptional programmes associated with compromised PU.1 activity, we adapted a Pu.1-mutated murine AML cell line with an inducible wild-type PU.1. PU.1 induction caused transition from leukaemia phenotype to monocytic differentiation. Global binding maps for PU.1, CEBPA and the histone mark H3K27Ac with and without PU.1 induction showed that mutant PU.1 retains DNA-binding ability, but the induction of wild-type protein dramatically increases both the number and the height of PU.1-binding peaks. Correlating chromatin immunoprecipitation (ChIP) Seq with gene expression data, we found that PU.1 recruitment coupled with increased histone acetylation induces gene expression and activates a monocyte/macrophage transcriptional programme. PU.1 induction also caused the reorganisation of a subgroup of CEBPA binding peaks. Finally, we show that the PU.1 target gene set defined in our model allows the stratification of primary human AML samples, shedding light on both known and novel AML subtypes that may be driven by PU.1 dysfunction.

  18. A combinatorial approach to the repertoire of RNA kissing motifs; towards multiplex detection by switching hairpin aptamers.

    Science.gov (United States)

    Durand, Guillaume; Dausse, Eric; Goux, Emma; Fiore, Emmanuelle; Peyrin, Eric; Ravelet, Corinne; Toulmé, Jean-Jacques

    2016-05-19

    Loop-loop (also known as kissing) interactions between RNA hairpins are involved in several mechanisms in both prokaryotes and eukaryotes such as the regulation of the plasmid copy number or the dimerization of retroviral genomes. The stability of kissing complexes relies on loop parameters (base composition, sequence and size) and base combination at the loop-loop helix - stem junctions. In order to identify kissing partners that could be used as regulatory elements or building blocks of RNA scaffolds, we analysed a pool of 5.2 × 10(6) RNA hairpins with randomized loops. We identified more than 50 pairs of kissing RNA hairpins. Two kissing motifs, 5'CCNY and 5'RYRY, generate highly stable complexes with KDs in the low nanomolar range. Such motifs were introduced in the apical loop of hairpin aptamers that switch between unfolded and folded state upon binding to their cognate target molecule, hence their name aptaswitch. The aptaswitch-ligand complex is specifically recognized by a second RNA hairpin named aptakiss through loop-loop interaction. Taking advantage of our kissing motif repertoire we engineered aptaswitch-aptakiss modules for purine derivatives, namely adenosine, GTP and theophylline and demonstrated that these molecules can be specifically and simultaneously detected by surface plasmon resonance or by fluorescence anisotropy. PMID:27067541

  19. 2000-2006 National Wood Energy Programme. 2000-2005 Activities Report

    International Nuclear Information System (INIS)

    2005 was marked by key decisions which were taken with the aim of developing the biomass sector as a substitute for fossil fuels. Indeed, to achieve the ambitious objectives for renewable sources of energy set out by the July 2005 Energy Policy Orientation Programme (POPE), we must make great use of biomass, particularly to increase by 50% the share of renewable thermal energy between now and 2010 and to enable biofuels to represent 7% of all fuels used at the same date. To a lesser extent, and in conjunction with heat production, the share of biomass in renewable electricity production also needs to rise. Both the resource and key supply players are there and are ready to get organised in order to rise to these challenges. There is an abundant supply of agricultural and forest by-products. More than sixty companies organise and deliver heating wood. More than 300 government and professional promotion, regulatory, PR, finance, equipment construction and operation, research and engineering organizations are involved in this market. The strategic and economic context is highly favourable in the light of laws, directives and international agreements aiming to combat greenhouse gas emissions, but also due to the structural pressure on the price of fossil fuels. Wood energy, as a renewable energy source, has an important role to play in this context of growth. Furthermore, the wood energy sector should be developed using an exemplary sustainable development approach, which means that all the economic, social and environmental effects are taken into account. In order to comprehensively assess the sector's environmental impact, a full chapter of this report presents the work and programmes set up by ADEME to reduce pollutant emissions produced by biomass combustion, particularly from private households. Moreover, consultation and dialogue between those involved must be widened in order to enable all wood users to benefit from 'best forest use' which will be a key

  20. National Wood-fuel Programme 2000-2006. Activity Report 2000-2006

    International Nuclear Information System (INIS)

    When ADEME launched its Wood-fuel programme throughout all of France in late 1999, its aim was to guide this resource supply chain to maturity and stable development in all user sectors: domestic, multi-family housing, commercial/institutional and industrial applications. To this end the Wood-fuel Programme 2000-2006 was assigned objectives and endowed with significant financial means for studies and coordination in order to support and carry out general-interest projects, piloted by ADEME. The stated goal was to replace fossil fuels, avoid carbon emissions and establish quality assurance standards for household firewood and wood-fired devices. This report presents: 1 - the Wood Energy stakes for the environment, for employment, and for the economy, the biomass energy net benefits; 2 - the Wood Energy key figures: Production and consumption, Single-family homes and wood heating, Breakdown of types of devices used, Sales of wood-fired devices, Number of housing/institutional boilers in use, Number of industrial boilers in use; 3 - the Wood Energy objectives: Domestic heating, Industrial boiler plants, District heating for housing/institutional/commercial uses; 4 - the Wood Energy program operation: Program coordination by ADEME, Partnerships and State-Region planning agreements, 2000-2006 funding system (modified in 2004) and Other financial instruments; 5 - the 2000-2006 assessment: Main results, Conclusions and recommendations, Evaluation contributions: five key points, Evaluation of employment in the solid biofuels supply chain, Supply for community, institutional and commercial boilers; 6 - Information and communication: Initiatives supported or accompanied by ADEME between 2000 and 2004, Publications supported by ADEME. In appendix: fuels and energy content, regional assessments, national research program on bio-energies - PNRB 2006 (Review and stakes, PNRB results in 2006), wood heating R and D, studies funded by ADEME, 2006 ADEME's correspondents, glossary

  1. Personal goals, group performance and ‘social’ networks: participants’ negotiation of virtual and embodied relationships in the ‘Workplace Challenge’ physical activity programme

    DEFF Research Database (Denmark)

    Evans, Adam Brian; Carter, Alice; Middleton, Geoff;

    2016-01-01

    -platform to encourage workplace-based teams to engage in physical activity by self-recording their activity over an eight-week period. Points were awarded for activity completed and a peer-challenge facility was promoted via online league tables, prizes and the opportunity to ‘challenge’ other users. Semi...... hierarchies have an impact upon participants’ perceptions of a programme....

  2. Percutaneous reconstruction of the innominate bifurcation using the retrograde 'kissing stents' technique

    Energy Technology Data Exchange (ETDEWEB)

    Nagata, Shun-ichi; Kazekawa, Kiyoshi; Matsubara, Shuko [Fukuoka University Chikushi Hospital, Department of Neurosurgery, Chikushino, Fukuoka (Japan); Sugata, Sei [Bironoki Neurosurgical Hospital, Shibushi, Kagoshima (Japan)

    2006-08-15

    Obstructions of the supraaortic vessels are an important cause of morbidity associated with a variety of symptoms. Percutaneous transluminal angioplasty has evolved as an effective and safe treatment modality for occlusive lesions of the supraaortic vessels. However, the endovascular management of an innominate bifurcation has not previously been reported. A 53-year-old female with a history of systematic hypertension, diabetes mellitus and hypercholesterolemia presented with left hemiparesis and dysarthria. Angiography of the innominate artery showed a stenosis of the innominate bifurcation. The lesion was successfully treated using the retrograde kissing stent technique via a brachial approach and an exposed direct carotid approach. The retrograde kissing stent technique for the treatment of a stenosis of the innominate bifurcation was found to be a safe and effective alternative to conventional surgery. (orig.)

  3. Endovascular reconstruction of iliac artery bifurcation atherosclerotic disease with the kissing technique.

    Science.gov (United States)

    Vourliotakis, Georgios; Mantas, Georgios; Katsargyris, Athanasios; Aivatidi, Christine; Kandounakis, Yannis

    2013-10-01

    A 71-year-old male patient with severe left buttock and lower-extremity claudication due to iliac artery bifurcation stenoses was referred to our institution for endovascular treatment. A 'kissing' technique was used in order to dilate the proximal parts of both internal and external iliac arteries and avoid compromization of the internal iliac artery during proximal external iliac artery stenting. A balloon expandable stent was inserted via a left ipsilateral retrograde access to the narrowed origin of the left external iliacartery and a balloon catheter via a right contralateral access inside the origin of the left internal iliac artery. Simultaneous balloons inflation restored full patency of both vessels. Twelve months later the patient is doing well, free of buttock or lower-extremity claudication symptoms. For iliac artery bifurcation atherosclerotic disease, endovascular repair with the 'kissing' technique can achieve a complete bifurcation reconstruction offering significant clinical benefit in selected patients. PMID:23493274

  4. Das Kindersprachscreening (KiSS) - ein Verfahren zur Sprachstandserfassung vierjähriger Kinder

    OpenAIRE

    NEUMANN, K; Holler-Zittlau, I; Sick, U; Zaretsky, Y; Euler, HA

    2009-01-01

    Einleitung: Zur Feststellung von Sprachförder- oder -therapiebedarf eignet sich ein Sprachscreening, sofern es eine ausreichende Validität aufweist und über streng algorithmische Kriterien zur Auffälligkeitsklassifizierung verfügt. Material und Methode: Für eine hessenweite Erfassung der vorschulischen Sprachkompetenz wurde das psychometrisch geprüfte Kindersprachscreening (KiSS) entwickelt. 257 Kinder im Alter von 4;0 bis 4;5 Jahren wurden mit einer Testbatterie auf ihren Sprachstand ...

  5. Assessing the Financial Viability of Academic Programmes

    Science.gov (United States)

    Swift, Lynette

    2012-01-01

    This paper reviews and examines approaches to determining the financial viability of academic programmes as a critical component of assessing a programme's overall sustainability. Key to assessing the financial viability of a programme is understanding the teaching activities required to deliver the programme and the cost of those activities. A…

  6. The Kiss-and-Run Model of Intra-Golgi Transport

    Directory of Open Access Journals (Sweden)

    Alexander A. Mironov

    2012-06-01

    Full Text Available The Golgi apparatus (GA is the main station along the secretory pathway. Mechanisms of intra-Golgi transport remain unresolved. Three models compete with each other for the right to be defined as the paradigm. The vesicular model cannot explain the following: (1 lipid droplets and aggregates of procollagen that are larger than coatomer I (COPI-dependent vesicles are transported across the GA; and (2 most anterograde cargoes are depleted in COPI vesicles. The compartment progression/maturation model has the following problems: (1 most Golgi-resident proteins are depleted in COPI vesicles; (2 there are no COPI vesicles for the recycling of the resident proteins in the trans-most-Golgi cisterna; and (3 different proteins have different rates of intra-Golgi transport. The diffusion model based on permanent inter-cisternal connections cannot explain the existence of lipid, ionic and protein gradients across the Golgi stacks. In contrast, the kiss-and-run model has the potential to explain most of the experimental observations. The kiss-and-run model can be symmetric when fusion and then fission occurs in the same place, and asymmetric when fusion takes place in one location, whereas fission takes place in another. The asymmetric kiss-and-run model resembles the carrier maturation mechanism, and it can be used to explain the transport of large cargo aggregates.

  7. REHABILITATION PRACTICAL PROGRAMME

    Directory of Open Access Journals (Sweden)

    Suzana KRANJC JOLDIKJ

    Full Text Available Centre for Education and Rehabilitation of Physi­cally Handicapped Children and Adolescents Kamnik (Zavod za usposabljanje invalidne mlad­ine Kamnik; hereinafter: ZUIM perform verified or state-ap­proved programme the Rehabilitation practical pro­gramme. The programme is intended for all those young people, who have completed primary school education, but cannot continue regular schooling in secondary school pro­grammes. The programme con­sists of several equivalent parts: education, practical work, train­ing work, health, therapeutic, psychologi­cal, and other activities. For every beginner in the first month of education members of the operative team create an individualized programme, which in­cludes individualized school work, individualized training programme, and other expert activities. The programme can last for 6 years maximum, it can however be completed earlier, when the op­erative team feels the training is no longer neces­sary. Pro­gress of a young person is what matters the most, and if there is no progress, the training is brought to an end. Training of young people in the Rehabilitation practical programme is only the be­ginning. The country will have to start considering social enter­prises, which are found elsewhere in the world, for example in Scandinavian countries and in the USA.

  8. The I.A.G. / A.I.G. SEDIBUD (Sediment Budgets in Cold Environments) Programme: Current and future activities

    Science.gov (United States)

    Beylich, Achim A.; Lamoureux, Scott; Decaulne, Armelle

    2013-04-01

    Projected climate change in cold regions is expected to alter melt season duration and intensity, along with the number of extreme rainfall events, total annual precipitation and the balance between snowfall and rainfall. Similarly, changes to the thermal balance are expected to reduce the extent of permafrost and seasonal ground frost and increase active layer depths. These effects will undoubtedly change surface environments in cold regions and alter the fluxes of sediments, nutrients and solutes, but the absence of quantitative data and coordinated geomorphic process monitoring and analysis to understand the sensitivity of the Earth surface environment is acute in cold climate environments. The International Association of Geomorphologists (I.A.G. / A.I.G. ) SEDIBUD (Sediment Budgets in Cold Environments) Programme was formed in 2005 to address this existing key knowledge gap. SEDIBUD currently has about 400 members worldwide and the Steering Committee of this international programme is composed of ten scientists from eight different countries: Achim A. Beylich (Chair) (Norway), Armelle Decaulne (Secretary) (France), John C. Dixon (USA), Scott F. Lamoureux (Vice-Chair) (Canada), John F. Orwin (Canada), Jan-Christoph Otto (Austria), Irina Overeem (USA), Thorsteinn Sæmundsson (Iceland), Jeff Warburton (UK) and Zbigniew Zwolinski (Poland). The central research question of this global group of scientists is to: Assess and model the contemporary sedimentary fluxes in cold climates, with emphasis on both particulate and dissolved components. Initially formed as European Science Foundation (ESF) Network SEDIFLUX (Sedimentary Source-to-Sink Fluxes in Cold Environments) (2004 - ), SEDIBUD has further expanded to a global group of researchers with field research sites located in polar and alpine regions in the northern and southern hemisphere. Research carried out at each of the close to 50 defined SEDIBUD key test sites varies by programme, logistics and available

  9. New Euratom research programme 2002-2006

    Energy Technology Data Exchange (ETDEWEB)

    Mustonen, R. [Radiation and Nuclear Safety Authority, Helsinki (Finland)

    2003-06-01

    The European Union funded research is carried out under two distinct programmes; the European Community Framework Programme (EC Programme) covering research, technological development and demonstration activities; and the Euratom Framework Programme covering research and training activities in the nuclear sector. The contents, funding and timetable of the sixth Euratom Framework Programme (FP6) are shortly reviewed in this paper. The European Union (EU) FP6 for the years 2002 - 2006 starts at the beginning of the year 2003.

  10. Changes in muscle activity after performing the FIFA 11+ programme part 2 for 4 weeks.

    Science.gov (United States)

    Takata, Yasushi; Nakase, Junsuke; Inaki, Anri; Mochizuki, Takafumi; Numata, Hitoaki; Oshima, Takeshi; Kinuya, Seigo; Tsuchiya, Hiroyuki

    2016-10-01

    Changes in muscle activity were evaluated by positron emission tomography-computed tomography (PET-CT) after performing part 2 of the Fédération Internationale de Football Association's 11+ programme (11+) for 4 weeks. Eleven males performed part 2 of the 11+ for 20 min before and after 37 MBq of (18)F-fluorodeoxyglucose (FDG) was injected intravenously. PET-CT images were obtained 50 min after FDG injection. The participants were then instructed to perform part 2 of the 11+ 3 times per week for 4 consecutive weeks, after which another set of PET-CT images was obtained following the same procedure. Regions of interest were defined within 30 muscles. The standardised uptake value (SUV) of FDG by muscle tissue per unit volume was calculated, and FDG accumulation was compared between pre- and post-training PET-CT results. Performing part 2 of the 11+ for 4 weeks increased mean SUV in the sartorius, semimembranosus, biceps femoris, abductor hallucis, and flexor hallucis brevis muscles (P < 0.05). In conclusion, routinely performing part 2 of the 11+ for 4 weeks increased glucose uptake related to muscle activity in the hamstrings and hallux muscles. We speculate that there is some possibility of this change of muscle activity contributing to a decrease in sports-related injuries. PMID:26911842

  11. European Identity through Space Space Activities and Programmes as a Tool to Reinvigorate the European Identity

    CERN Document Server

    Baranes, Blandina

    2013-01-01

    Space activities are one particularly visible area, where Europe can shape its identity. This publication investigates the effect space activities have already had on building a European “spirit” (e.g. through European missions or European astronauts). It also looks into the effects that activities labelled “national” have on the emergence of a European identity. Based on this analysis, the book's intention is to identify creative ways and means for how to further use space for shaping the European identity. For this purpose the focus is not only on policy analysis but also on expertise from the fields of cultural science and the arts in order to tap their creative potential and also their theoretical approaches to the topic. Selecting this theme provides ESPI with another opportunity to develop its trans-disciplinary approach.

  12. A thin film active-lens with translational control for dynamically programmable optical zoom

    Science.gov (United States)

    Yun, Sungryul; Park, Suntak; Park, Bongje; Nam, Saekwang; Park, Seung Koo; Kyung, Ki-Uk

    2015-08-01

    We demonstrate a thin film active-lens for rapidly and dynamically controllable optical zoom. The active-lens is composed of a convex hemispherical polydimethylsiloxane (PDMS) lens structure working as an aperture and a dielectric elastomer (DE) membrane actuator, which is a combination of a thin DE layer made with PDMS and a compliant electrode pattern using silver-nanowires. The active-lens is capable of dynamically changing focal point of the soft aperture as high as 18.4% through its translational movement in vertical direction responding to electrically induced bulged-up deformation of the DE membrane actuator. Under operation with various sinusoidal voltage signals, the movement responses are fairly consistent with those estimated from numerical simulation. The responses are not only fast, fairly reversible, and highly durable during continuous cyclic operations, but also large enough to impart dynamic focus tunability for optical zoom in microscopic imaging devices with a light-weight and ultra-slim configuration.

  13. Greek Teachers Programme 2015

    CERN Multimedia

    Hoch, Michael

    2015-01-01

    The 3rd edition of this year's Greek Teachers Programme was co-organized by CERN Education Group and the Hellenic Physical Society and took place from 8 to 12 November 2015. The programme targets physics high-school teachers from all over Greece. It aims to help teachers inspire the next generation of scientists and engineers by motivating their students to understand and appreciate how science works at the world's largest physics laboratory, whereby increasing their interest in pursuing studies in STEM fields in secondary and post-secondary education. 33 teachers took part in this programme which comprised lectures by Greek members of the CERN scientific community, with visits to experimental facilities, hands-on activities and dedicated sessions on effective and creative ways through which participants may bring physics, particle physics and CERN closer to their school classroom. In 2015, more than 100 teachers took part in the three editions of the Greek Teachers Programme.

  14. Programmable SERS active substrates for chemical and biosensing applications using amorphous/crystalline hybrid silicon nanomaterial

    OpenAIRE

    Jeffery Alexander Powell; Krishnan Venkatakrishnan; Bo Tan

    2016-01-01

    We present the creation of a unique nanostructured amorphous/crystalline hybrid silicon material that exhibits surface enhanced Raman scattering (SERS) activity. This nanomaterial is an interconnected network of amorphous/crystalline nanospheroids which form a nanoweb structure; to our knowledge this material has not been previously observed nor has it been applied for use as a SERS sensing material. This material is formed using a femtosecond synthesis technique which facilitates a laser plu...

  15. Design of a process evaluation of the implementation of a physical activity and sports stimulation programme in Dutch rehabilitation setting : ReSpAct

    NARCIS (Netherlands)

    Hoekstra, Femke; Alingh, Roelina A.; van der Schans, Cees P.; Hettinga, Florentina J.; Duijf, Marjo; Dekker, Rienk; van der Woude, Lucas H. V.

    2014-01-01

    Background: There is a growing interest to study the transfer of evidence-based information into daily practice. The evidence-based programme Rehabilitation, Sports and Exercise (RSE) that aims to stimulate an active lifestyle during and after a rehabilitation period in people with a disability and/

  16. Development and evaluation of a structured programme for promoting physical activity among seniors with intellectual disabilities: a study protocol for a cluster randomized trial

    NARCIS (Netherlands)

    Schijndel-Speet, M. van; Evenhuis, H.M.; Empelen, P. van; Wijck, R. van; Echteld, M.A.

    2013-01-01

    Older people with intellectual disabilities have very low physical activity levels. Well designed, theory-driven and evidence-based health promotion programmes for the target population are lacking. This paper describes the design of a cluster-randomised trial for a systematically developed health p

  17. Cost-Effectiveness of a Long-Term Internet-Delivered Worksite Health Promotion Programme on Physical Activity and Nutrition: A Cluster Randomized Controlled Trial

    Science.gov (United States)

    Robroek, Suzan J. W.; Polinder, Suzanne; Bredt, Folef J.; Burdorf, Alex

    2012-01-01

    This study aims to evaluate the cost-effectiveness of a long-term workplace health promotion programme on physical activity (PA) and nutrition. In total, 924 participants enrolled in a 2-year cluster randomized controlled trial, with departments (n = 74) within companies (n = 6) as the unit of randomization. The intervention was compared with a…

  18. Systematic review on the financial return of worksite health promotion programmes aimed at improving nutrition and/or increasing physical activity

    NARCIS (Netherlands)

    Dongen, J.M. van; Proper, K.I.; Wier, M.F. van; Beek, A.J. van der; Bongers, P.M.; Mechelen, W. van; Tulder, M.W. van

    2011-01-01

    Summary: This systematic review summarizes the current evidence on the financial return of worksite health promotion programmes aimed at improving nutrition and/or increasing physical activity. Data on study characteristics and results were extracted from 18 studies published up to 14 January 2011.

  19. Mutations of the kissing-loop dimerization sequence influence the site specificity of murine leukemia virus recombination in vivo

    DEFF Research Database (Denmark)

    Mikkelsen, J G; Lund, Anders Henrik; Duch, M;

    2000-01-01

    The genetic information of retroviruses is retained within a dimeric RNA genome held together by intermolecular RNA-RNA interactions near the 5' ends. Coencapsidation of retrovirus-derived RNA molecules allows frequent template switching of the virus-encoded reverse transcriptase during DNA...... synthesis in newly infected cells. We have previously shown that template shifts within the 5' leader of murine leukemia viruses occur preferentially within the kissing stem-loop motif, a cis element crucial for in vitro RNA dimer formation. By use of a forced recombination approach based on single...... specificity of recombination within the highly structured 5' leader region. In addition, we find that an intact kissing-loop sequence favors optimal RNA encapsidation and vector transduction. Our data are consistent with the kissing-loop dimerization model and suggest that a direct intermolecular RNA...

  20. Unravelling the Evolution of the Allatostatin-Type A, KISS and Galanin Peptide-Receptor Gene Families in Bilaterians: Insights from Anopheles Mosquitoes.

    Directory of Open Access Journals (Sweden)

    Rute C Felix

    Full Text Available Allatostatin type A receptors (AST-ARs are a group of G-protein coupled receptors activated by members of the FGL-amide (AST-A peptide family that inhibit food intake and development in arthropods. Despite their physiological importance the evolution of the AST-A system is poorly described and relatively few receptors have been isolated and functionally characterised in insects. The present study provides a comprehensive analysis of the origin and comparative evolution of the AST-A system. To determine how evolution and feeding modified the function of AST-AR the duplicate receptors in Anopheles mosquitoes, were characterised. Phylogeny and gene synteny suggested that invertebrate AST-A receptors and peptide genes shared a common evolutionary origin with KISS/GAL receptors and ligands. AST-ARs and KISSR emerged from a common gene ancestor after the divergence of GALRs in the bilaterian genome. In arthropods, the AST-A system evolved through lineage-specific events and the maintenance of two receptors in the flies and mosquitoes (Diptera was the result of a gene duplication event. Speciation of Anopheles mosquitoes affected receptor gene organisation and characterisation of AST-AR duplicates (GPRALS1 and 2 revealed that in common with other insects, the mosquito receptors were activated by insect AST-A peptides and the iCa2+-signalling pathway was stimulated. GPRALS1 and 2 were expressed mainly in mosquito midgut and ovaries and transcript abundance of both receptors was modified by feeding. A blood meal strongly up-regulated expression of both GPRALS in the midgut (p < 0.05 compared to glucose fed females. Based on the results we hypothesise that the AST-A system in insects shared a common origin with the vertebrate KISS system and may also share a common function as an integrator of metabolism and reproduction.AST-A and KISS/GAL receptors and ligands shared common ancestry prior to the protostome-deuterostome divergence. Phylogeny and gene

  1. Medical education and the GCSE generation--a transferable activity-skills programme in medical sociology.

    Science.gov (United States)

    Fox, N J; Dryden, C

    1991-01-01

    The first major intake of medical students who studied the new GCSE occurred in Autumn 1990. These students have experienced a range of student-centred educational approaches to learning, but medical education in the UK remains committed to teacher-centred approaches. This mismatch of expectations is discussed. An innovative course in medical sociology at the University of Sheffield is reported, which illustrates student-centred learning approaches including transferable activity-skills development and self-assessment profiling. An innovative approach to course evaluation is discussed. PMID:1749350

  2. Programmable SERS active substrates for chemical and biosensing applications using amorphous/crystalline hybrid silicon nanomaterial

    Science.gov (United States)

    Powell, Jeffery Alexander; Venkatakrishnan, Krishnan; Tan, Bo

    2016-01-01

    We present the creation of a unique nanostructured amorphous/crystalline hybrid silicon material that exhibits surface enhanced Raman scattering (SERS) activity. This nanomaterial is an interconnected network of amorphous/crystalline nanospheroids which form a nanoweb structure; to our knowledge this material has not been previously observed nor has it been applied for use as a SERS sensing material. This material is formed using a femtosecond synthesis technique which facilitates a laser plume ion condensation formation mechanism. By fine-tuning the laser plume temperature and ion interaction mechanisms within the plume, we are able to precisely program the relative proportion of crystalline Si to amorphous Si content in the nanospheroids as well as the size distribution of individual nanospheroids and the size of Raman hotspot nanogaps. With the use of Rhodamine 6G (R6G) and Crystal Violet (CV) chemical dyes, we have been able to observe a maximum enhancement factor of 5.38 × 106 and 3.72 × 106 respectively, for the hybrid nanomaterial compared to a bulk Si wafer substrate. With the creation of a silicon-based nanomaterial capable of SERS detection of analytes, this work demonstrates a redefinition of the role of nanostructured Si from an inactive to SERS active role in nano-Raman sensing applications.

  3. Endovascular Treatment of Blunt Traumatic Abdominal Aortic Occlusion With Kissing Stent Placement

    Energy Technology Data Exchange (ETDEWEB)

    Idoguchi, Koji, E-mail: idoguchi@ares.eonet.ne.jp; Yamaguchi, Masato; Okada, Takuya [Kobe University Hospital, Department of Radiology and Center for Endovascular Therapy (Japan); Nomura, Yoshikatsu [Kobe University Hospital, Department of Cardiovascular Surgery (Japan); Sugimura, Kazuro [Kobe University Hospital, Department of Radiology and Center for Endovascular Therapy (Japan); Okita, Yutaka [Kobe University Hospital, Department of Cardiovascular Surgery (Japan); Sugimoto, Koji [Kobe University Hospital, Department of Radiology and Center for Endovascular Therapy (Japan)

    2012-10-15

    Blunt traumatic abdominal aortic dissection is extremely rare and potentially deadly. We present the case of a 62-year-old man involved in a frontal car crash. After emergency undergoing laparotomy for bowel injuries, he was referred to our hospital due to acute ischemia of bilateral lower extremities on day 3 after the trauma. Computed tomography and aortography showed an aortobiiliac dissection with complete occlusion. This injury was successfully treated by endovascular treatment with 'kissing'-technique stent placement, which appears to be a safe, effective, and minimally invasive treatment.

  4. Bio-optofluidics and Bio-photonics: Programmable Phase Optics activities at DTU Fotonik

    DEFF Research Database (Denmark)

    Bañas, Andrew Rafael; Palima, Darwin; Pedersen, Finn;

    We present ongoing research and development activities for constructing a compact next generation BioPhotonics Workstation and a Bio-optofluidic Cell Sorter (cell-BOCS) for all-optical micromanipulation platforms utilizing low numerical aperture beam geometries. Unlike conventional high NA optical...... tweezers, the BioPhotonics workstation is e.g. capable of long range 3D manipulation. This enables a variety of biological studies such as manipulation of intricate microfabricated assemblies or for automated and parallel optofluidic cell sorting. To further reduce its overhead, we propose ways of making...... the BioPhotonics Workstation platform more photon efficient by studying the 3D distribution of the counter propagating beams and utilizing the Generalized Phase Contrast (GPC) method for illuminating the applied spatial light modulators....

  5. Aberrant Expression of Kiss-1 and Matrix Metalloproteinase-9 Are Closely Linked to Lymph Node Metastasis of Gastric Cancer

    Institute of Scientific and Technical Information of China (English)

    Hua-chuan Zheng; Ai-ming Yu; Yan Xin

    2008-01-01

    @@ China is one of the countries with the highest risk of gastric cancer over the past century, which is still the lead-ing cause of death worldwide. Because metastatic disease of gastric cancer is the most critical impediment to patient survival, it is necessary to further understand the molecular mechanisms of its metastasis. Kiss-1, mapping to chromo-some lq32, is one of these genes regulated at chromosome 6. Kiss-1 expression was discovered to inhibit metastasis in both in vivo melanoma and breast carcinoma models.

  6. 对“Kiss Lands Iranian Actress and Director in Court”的译文的几点看法

    Institute of Scientific and Technical Information of China (English)

    于德兰

    2003-01-01

    读吴来哉选译的文章“Kiss Lands Iranian Actress and Director in Court”(贵刊2002年第11期),发现译文在表达上尚存缺憾。现简析如下,与吴教授切磋。A kiss planted on the forehead of a young Iranian director by a well-known actress has landed the pair in court and sparked heated protest in the Islamic Republic over physical contact between the sexes.

  7. Hibernation as a Far-Reaching Programme for Cell Nucleus Activity Modulation

    Science.gov (United States)

    Malatesta, M.; Biggiogera, M.; Zancanaro, C.

    Maintaining part of the crew under hypometabolic conditions could help with the problems associated with long-term space missions. In the natural world, hibernators represent the most suitable model for a hypometabolic state. These animals are, in fact, able to drastically reduce all metabolic and physiological activities under adverse environmental conditions, but they can rapidly leave the depressed metabolic state as soon as the environment becomes favourable. Hibernators' cellular machinery must therefore undergo adaptive morpho-functional modifications to allow survival. Our studies on tissues of hibernating dormice revealed that the cell nucleus undergoes an important structural reorganisation during the hypometabolic period. Interestingly, despite the drastic reduction in pre-mRNA transcriptional and processing rate, cell nuclei of hibernating dormice never showed features typical of quiescence. Recent analyses revealed that pre-mRNA processing factors undergo an intranuclear redistribution which varies in different tissues. This suggests a programmed intranuclear reorganization of such molecules aimed to an efficient and rapid restoration of pre-mRNA processing upon arousal. Natural hibernation therefore appears as a highly programmed hypometabolic state rather than a simple fall of metabolic and physiological functions.

  8. Activating welfare recipients with health complaints: Reasons for failure of a cognitive training programme

    Directory of Open Access Journals (Sweden)

    Inge Bramsen

    2011-03-01

    Een groeiende nadruk op de activering van uitkeringsgerechtigden heeft in veel Westerse verzorgingsstaten geleid tot de ontwikkeling van interventies die gericht zijn op uitkeringsgerechtigden met gezondheidsklachten. Vormen van dwang, zoals verplichte participatie, worden meer en meer toegepast binnen dit activeringsbeleid. Een voorbeeld hiervan is het Nederlandse project “Gezond aan de Slag”, dat een interventie ontwikkelde en evalueerde waarin een fysiek trainingsprogramma gecombineerd wordt met cognitieve training. Hoewel HtW als “best practice” gold, liet een randomized trial geen positieve effecten van de interventie zien. Omdat het cognitieve trainingsprogramma, gebaseerd op rationeel-emotieve therapie, niet eerder afzonderlijk werd bestudeerd, werd een diepgaande kwalitatieve studie uitgevoerd. Getracht werd om de oorzaken van het falen van het programma in kaart te brengen. Zes, gericht geselecteerde, trainers werden geïnterviewd. De resultaten lieten zien dat de trainers problemen hadden met de heterogeniteit van de deelnemersgroep en op andere problemen, verwachtingen en arbeidsmarktobstakels stuitten dan vooraf verwacht. De verplichte aard van HtW had een negatief effect op de motivatie van zowel deelnemers als trainers. In de discussieparagraaf van dit artikel worden vraagtekens geplaatst bij de veronderstelling dat de coping stijl en cognities van uitkeringsgerechtigden met gezondheidsproblemen de belangrijkste hindernissen zijn voor het vinden van werk, en worden vraagtekens geplaatst bij het beleid om fysieke beperkingen van deelnemers te negeren. De auteurs suggereren dat met betrekking tot dit complexe praktijkprobleem, verbetering kan worden bereikt door aanpassen en leren van de interventie gedurende de toepassing daarvan toe te staan, en door expliciet te reflecteren op de normatieve aspecten van de interventie, en de perspectieven van de uitkeringsgerechtigden zelf.

  9. Nutritional counselling and its effects on diet, nutritional knowledge and status, physical activity and quality of life in a Southern Europe population: evaluation of a health promotion programme.

    Directory of Open Access Journals (Sweden)

    Cecilia Quercioli

    2011-06-01

    Full Text Available

    Abstract:
    Background: Health promotion and primary prevention are key points for fighting the increase in non- communicable diseases. Aim: To test the effectiveness of a nutritional counselling programme in improving nutritional behaviours, knowledge and status, physical activity and health-related quality of life in a general population. Methods: In the period between January–December 2007, we studied the application of the nutritional counselling programme (NCP developed by Local Health Agency 10 (Florence-Italy. We compared , diet, nutritional knowledge, physical activity, health related quality of life (measured by SF36 questionnaire, body mass index (BMI and waist circumference before and after a two months intensive nutritional counselling programme using the paired t test and McNemar test. Diet, nutritional knowledge, physical activity, socio-demographic and morbidity information were collected through questionnaires. BMI and waist circumference were assessed by a medical doctor. Results: We enrolled 74 persons, 59 of whom completed the educational programme. Of these, 34 had a nutritional status assessment after the programme. Mean age was 49 years, 80% were females. BMI, waist circumference and diet, except for water intake, did not change. The percentage of people who had “never exercised in a week" decreased from 46% to 17% (p<0.001. Mean percentage of right answers to nutritional knowledge indicators increased from 64% to 78% (p<0.001. Health related quality of life (HRQL improved especially with regard to “Physical" and “Emotional Role". Conclusions: The NCP showed important results in promoting physical activity and improving HRQL and nutritional knowledge, moderate/none results in improving diet and nutritional status.

  10. Review of fast reactor physics activities relevant to LMFBR programme in PNC, Japan, June 1976 - May 1977

    International Nuclear Information System (INIS)

    Fast reactor physics activities performed during a year from June, 1976, to May, 1977, along with the programme in PNC are reviewed. The first topic is the start up of JOYO which attained the criticality on April 24, 1977. Present status of the design of MONJU and the design study of the demonstration fast breeder reactor are briefly reviewed in the second part. The rest of this report presents the results of more specific studies as follows. (1) Mockup experiment in FCA and analysis to support MONJU design. (2) Parameter study on the breeding characteristics of a 1000 MWe class LMFBR. (3) Evaluation of actinide nuclear data. (4) Detailed analysis of sodium void experiments. (5) The improvement of LSQ program for sensitivity analysis. (6) Effect of size of the critical mockup on the extrapolation errors in predicting neutronic properties of a 1000 MWe core. (7) Research on the two-dimensional calculational method for shielding, and application to MONJU design and to the evaluation of neutrons streaming through a primary sodium duct of JOYO. (Aoki, K.)

  11. Monitoring programme

    International Nuclear Information System (INIS)

    Her Majesty's Inspectorate of Pollution's 1992 report on its programme of monitoring radioactive substances is presented. Site operators' returns are verified and the report provides independent data on the environmental impact of authorized disposal of radioactive wastes. Radiation doses which may have been received by members of the public, fall well below the International Commission for Radiological Protection's (ICRP) recommended annual doses. (UK)

  12. The kissing-loop T-shaped structure translational enhancer of Pea enation mosaic virus can bind simultaneously to ribosomes and a 5' proximal hairpin.

    Science.gov (United States)

    Gao, Feng; Gulay, Suna P; Kasprzak, Wojciech; Dinman, Jonathan D; Shapiro, Bruce A; Simon, Anne E

    2013-11-01

    The Pea enation mosaic virus (PEMV) 3' translational enhancer, known as the kissing-loop T-shaped structure (kl-TSS), binds to 40S subunits, 60S subunits, and 80S ribosomes, whereas the Turnip crinkle virus (TCV) TSS binds only to 60S subunits and 80S ribosomes. Using electrophoretic mobility gel shift assay (EMSA)-based competition assays, the kl-TSS was found to occupy a different site in the ribosome than the P-site-binding TCV TSS, suggesting that these two TSS employ different mechanisms for enhancing translation. The kl-TSS also engages in a stable, long-distance RNA-RNA kissing-loop interaction with a 12-bp 5'-coding-region hairpin that does not alter the structure of the kl-TSS as revealed by molecular dynamics simulations. Addition of the kl-TSS in trans to a luciferase reporter construct containing either wild-type or mutant 5' and 3' PEMV sequences suppressed translation, suggesting that the kl-TSS is required in cis to function, and both ribosome-binding and RNA interaction activities of the kl-TSS contributed to translational inhibition. Addition of the kl-TSS was more detrimental for translation than an adjacent eIF4E-binding 3' translational enhancer known as the PTE, suggesting that the PTE may support the ribosome-binding function of the kl-TSS. Results of in-line RNA structure probing, ribosome filter binding, and high-throughput selective 2'-hydroxyl acylation analyzed by primer extension (hSHAPE) of rRNAs within bound ribosomes suggest that kl-TSS binding to ribosomes and binding to the 5' hairpin are compatible activities. These results suggest a model whereby posttermination ribosomes/ribosomal subunits bind to the kl-TSS and are delivered to the 5' end of the genome via the associated RNA-RNA interaction, which enhances the rate of translation reinitiation. PMID:23986599

  13. Intervention dose estimation in health promotion programmes: a framework and a tool. Application to the diet and physical activity promotion PRALIMAP trial

    Directory of Open Access Journals (Sweden)

    Legrand Karine

    2012-09-01

    Full Text Available Abstract Background Although the outcomes of health promotion and prevention programmes may depend on the level of intervention, studies and trials often fail to take it into account. The objective of this work was to develop a framework within which to consider the implementation of interventions, and to propose a tool with which to measure the quantity and the quality of activities, whether planned or not, relevant to the intervention under investigation. The framework and the tool were applied to data from the diet and physical activity promotion PRALIMAP trial. Methods A framework allowing for calculation of an intervention dose in any health promotion programme was developed. A literature reviews revealed several relevant concepts that were considered in greater detail by a multidisciplinary working group. A method was devised with which to calculate the dose of intervention planned and that is actually received (programme-driven activities dose, as well as the amount of non-planned intervention (non-programme-driven activities dose. Results Indicators cover the roles of all those involved (supervisors, anchor personnel as receivers and providers, targets, in each intervention-related groups (IRG: basic setting in which a given intervention is planned by the programme and may differ in implementation level and for every intervention period. All indicators are described according to two domains (delivery, participation in two declensions (quantity and quality. Application to PRALIMAP data revealed important inter- and intra-IRG variability in intervention dose. Conclusions A literature analysis shows that the terminology in this area is not yet consolidated and that research is ongoing. The present work provides a methodological framework by specifying concepts, by defining new constructs and by developing multiple information synthesis methods which must be introduced from the programme's conception. Application to PRALIMAP underlined the

  14. VIP in construction: systematic development and evaluation of a multifaceted health programme aiming to improve physical activity levels and dietary patterns among construction workers

    Directory of Open Access Journals (Sweden)

    Viester Laura

    2012-01-01

    Full Text Available Abstract Background The prevalence of both overweight and musculoskeletal disorders (MSD in the construction industry is high. Many interventions in the occupational setting aim at the prevention and reduction of these health problems, but it is still unclear how these programmes should be designed. To determine the effectiveness of interventions on these health outcomes randomised controlled trials (RCTs are needed. The aim of this study is to systematically develop a tailored intervention for prevention and reduction of overweight and MSD among construction workers and to describe the evaluation study regarding its (cost-effectiveness. Methods/Design The Intervention Mapping (IM protocol was applied to develop and implement a tailored programme aimed at the prevention and reduction of overweight and MSD. The (cost- effectiveness of the intervention programme will be evaluated using an RCT. Furthermore, a process evaluation will be conducted. The research population will consist of blue collar workers of a large construction company in the Netherlands. Intervention The intervention programme will be aimed at improving (vigorous physical activity levels and healthy dietary behaviour and will consist of tailored information, face-to-face and telephone counselling, training instruction (a fitness "card" to be used for exercises, and materials designed for the intervention (overview of the company health promoting facilities, waist circumference measuring tape, pedometer, BMI card, calorie guide, recipes, and knowledge test. Main study parameters/endpoints The intervention effect on body weight and waist circumference (primary outcome measures, as well as on lifestyle behaviour, MSD, fitness, CVD risk indicators, and work-related outcomes (i.e. productivity, sick leave (secondary outcome measures will be assessed. Discussion The development of the VIP in construction intervention led to a health programme tailored to the needs of construction

  15. Serine protease inhibitor 6 is required to protect dendritic cells from the kiss of death.

    Science.gov (United States)

    Lovo, Elena; Zhang, Manling; Wang, Lihui; Ashton-Rickardt, Philip G

    2012-02-01

    How dendritic cells (DC) present Ag to cytotoxic T cells (CTL) without themselves being killed through contact-mediated cytotoxicity (so-called kiss of death) has proved to be controversial. Using mice deficient in serine protease inhibitor 6 (Spi6), we show that Spi6 protects DC from the kiss of death by inhibiting granzyme B (GrB) delivered by CTL. Infection of Spi6 knockout mice with lymphocytic choriomeningitis virus revealed impaired survival of CD8α DC. The impaired survival of Spi6 knockout CD8α DC resulted in impaired priming and expansion of both primary and memory lymphocytic choriomeningitis virus-specific CTL, which could be corrected by GrB deficiency. The rescue in the clonal burst obtained by GrB elimination demonstrated that GrB was the physiological target through which Spi6 protected DC from CTL. We conclude that the negative regulation of DC priming of CD8 T lymphocyte immunity by CTL killing is mitigated by the physiological inhibition of GrB by Spi6.

  16. Valve-Like and Protruding Calcified Intimal Flap Complicating Common Iliac Arteries Kissing Stenting

    Science.gov (United States)

    Georgiadis, George S.; Georgakarakos, Efstratios I.; Schoretsanitis, Nikolaos; Argyriou, Christos C.; Antoniou, George A.; Lazarides, Miltos K.

    2015-01-01

    Endovascular therapy for iliac artery chronic total occlusions is nowadays associated with low rates of procedure-related complications and improved clinical outcomes, and it is predominantly used as first-line therapy prior to aortobifemoral bypass grafting. Herein, we describe the case of a patient presenting with an ischemic left foot digit ulcer and suffering complex aortoiliac lesions, who received common iliac arteries kissing stents, illustrating at final antegrade and retrograde angiograms the early recognition of a blood flow obstructing valve-like calcified intimal flap protruding through the stent struts, which was obstructing antegrade but not retrograde unilateral iliac arterial axis blood flow. The problem was resolved by reconstructing the aortic bifurcation at a more proximal level. Completion angiogram verified normal patency of aorta and iliac vessels. Additionally, a severe left femoral bifurcation stenosis was also corrected by endarterectomy-arterioplasty with a bovine patch. Postintervention ankle brachial pressure indices were significantly improved. At the 6-month and 2-year follow-up, normal peripheral pulses were still reported without intermittent claudication suggesting the durability of the procedure. Through stent-protruding calcified intimal flap, is a very rare, but existing source of antegrade blood flow obstruction after common iliac arteries kissing stents. PMID:26783493

  17. Valve-Like and Protruding Calcified Intimal Flap Complicating Common Iliac Arteries Kissing Stenting.

    Science.gov (United States)

    Georgiadis, George S; Georgakarakos, Efstratios I; Schoretsanitis, Nikolaos; Argyriou, Christos C; Antoniou, George A; Lazarides, Miltos K

    2015-01-01

    Endovascular therapy for iliac artery chronic total occlusions is nowadays associated with low rates of procedure-related complications and improved clinical outcomes, and it is predominantly used as first-line therapy prior to aortobifemoral bypass grafting. Herein, we describe the case of a patient presenting with an ischemic left foot digit ulcer and suffering complex aortoiliac lesions, who received common iliac arteries kissing stents, illustrating at final antegrade and retrograde angiograms the early recognition of a blood flow obstructing valve-like calcified intimal flap protruding through the stent struts, which was obstructing antegrade but not retrograde unilateral iliac arterial axis blood flow. The problem was resolved by reconstructing the aortic bifurcation at a more proximal level. Completion angiogram verified normal patency of aorta and iliac vessels. Additionally, a severe left femoral bifurcation stenosis was also corrected by endarterectomy-arterioplasty with a bovine patch. Postintervention ankle brachial pressure indices were significantly improved. At the 6-month and 2-year follow-up, normal peripheral pulses were still reported without intermittent claudication suggesting the durability of the procedure. Through stent-protruding calcified intimal flap, is a very rare, but existing source of antegrade blood flow obstruction after common iliac arteries kissing stents. PMID:26783493

  18. Valve-Like and Protruding Calcified Intimal Flap Complicating Common Iliac Arteries Kissing Stenting

    Directory of Open Access Journals (Sweden)

    George S. Georgiadis

    2015-01-01

    Full Text Available Endovascular therapy for iliac artery chronic total occlusions is nowadays associated with low rates of procedure-related complications and improved clinical outcomes, and it is predominantly used as first-line therapy prior to aortobifemoral bypass grafting. Herein, we describe the case of a patient presenting with an ischemic left foot digit ulcer and suffering complex aortoiliac lesions, who received common iliac arteries kissing stents, illustrating at final antegrade and retrograde angiograms the early recognition of a blood flow obstructing valve-like calcified intimal flap protruding through the stent struts, which was obstructing antegrade but not retrograde unilateral iliac arterial axis blood flow. The problem was resolved by reconstructing the aortic bifurcation at a more proximal level. Completion angiogram verified normal patency of aorta and iliac vessels. Additionally, a severe left femoral bifurcation stenosis was also corrected by endarterectomy-arterioplasty with a bovine patch. Postintervention ankle brachial pressure indices were significantly improved. At the 6-month and 2-year follow-up, normal peripheral pulses were still reported without intermittent claudication suggesting the durability of the procedure. Through stent-protruding calcified intimal flap, is a very rare, but existing source of antegrade blood flow obstruction after common iliac arteries kissing stents.

  19. The KISS Project - Exploring the magmatic system beneath Kamchatka's volcanoes

    Science.gov (United States)

    Luehr, Birger-G.; Shapiro, Nikolai; Abkadyrov, Ilyas; Sens-Schönfelder, Christoph; Koulakov, Ivan; Jakovlev, Andrey; Abramenkov, Sergey; Saltykov, Vadim A.; Heit, Benjamin; Weber, Michael; Gordeev, Evgeny I.; Chebrov, Victor N.

    2016-04-01

    In a joint initiative of GFZ with Russian (IPGG, IVS, KGBS) and a French partner (IPGP) a temporary seismological network has been installed around the Klyuchevskoy volcanic group in Central Kamchatka. The Klyuchevskoy volcanic group is an ensemble of 13 stratovolcanoes with very different compositions and eruption styles in a ~70km diameter area which produced at least 30 VEI≥2 episodes during the last 15 years. Latest activity of the highest volcano Klyuchevskoy (4754 m) was in spring 2015. The group is located right on the triple junction between Asian, Pacifc and North American plates where the Hawaiian-Emperor seamount chain separates the Aleutian and the Kuril-Kamchatka trenches. The complex setting presumably leads to processes like increased melting at slab edges and/or accelerated mantle flow which affect the volcanism and might be responsible for the unparalleled concentration of volcanic activity in the Klyuchevskoy group. Due to the difficult field conditions and special permitting regulations seismological investigations have been rare in Kamchatka. In this consortium we build strongly on the experience of the Kamchatkan partners for permitting and logistics. Installation was done to about 50% by helicopter. Funding was provided via a grant from the Russian Science Foundation (grant 14-47-00002) to the IVS/KBGS/IPGG, the GFZ, and the IPGP. 60 of the stations were provided by the GFZ instrument pool GIPP. Including the permanent stations operated by KGBS and temporary stations provided by the partners, the network consist of 98 stations and will record earthquakes volcanic signals and the ambient field over one year in an area of approximately 150 by 150km.

  20. Molecular identification of Kiss/GPR54 and function analysis with mRNA expression profiles exposure to 17α-ethinylestradiol in rare minnow Gobiocypris rarus.

    Science.gov (United States)

    Yang, Yanping; Gao, Jiancao; Yuan, Cong; Zhang, Yingying; Guan, Yongjing; Wang, Zaizhao

    2016-07-01

    17α-ethinylestradiol (EE2) is a widely existed endocrine disrupting chemical in water environment. Kisspeptins act as indispensable regulators through GPR54 in the hypothalamic-pituitary-gonadal (HPG) axis. This study aimed to provide further understanding of the effect of EE2 on HPG axis. Molecular cloning and tissue distribution of kiss genes and GPR54s were performed in Gobiocypris rarus. The mRNA expression profiles of kiss1, kiss2, GPR54s and GnRHs were detected in G. rarus brain and/or gonad following 3- and 6-days EE2 (1, 5, 25 and 125 ng/L) exposure. Results showed that kiss genes and GPR54s were highly expressed in brain and gonad. Both kiss1 and kiss2 were increased in female brain and suppressed in male brain following EE2 exposure. GnRHs were inhibited in a concentration-dependent manner in male brain following 3-days EE2 exposure. In gonad, GPR54b was almost suppressed in all of EE2 concentrations. The present findings suggest that EE2 impacts the genes expression of Kiss/GPR54-GnRH system in G. rarus, thereby probably disturbing the neuroendocrine homeostasis. PMID:27216535

  1. Programmable Oscillator

    Science.gov (United States)

    Quirk, Kevin J.; Patawaran, Ferze D.; Nguyen, Danh H.; Lee, Clement G.; Nguyen, Huy

    2011-01-01

    A programmable oscillator is a frequency synthesizer with an output phase that tracks an arbitrary function. An offset, phase-locked loop circuit is used in combination with an error control feedback loop to precisely control the output phase of the oscillator. To down-convert the received signal, several stages of mixing may be employed with the compensation for the time-base distortion of the carrier occurring at any one of those stages. In the Goldstone Solar System Radar (GSSR), the compensation occurs in the mixing from an intermediate frequency (IF), whose value is dependent on the station and band, to a common IF used in the final stage of down-conversion to baseband. The programmable oscillator (PO) is used in the final stage of down-conversion to generate the IF, along with a time-varying phase component that matches the time-base distortion of the carrier, thus removing it from the final down-converted signal.

  2. ADS National Programmes: France

    International Nuclear Information System (INIS)

    Studies related to nuclear reactors and radioactive waste started at the French National Centre for Scientific research, CNRS, as a result of the French law on radioactive waste that was published in 1991. They were initially organized around the programme PACE (Physique pour l’Aval du Cycle Electronucléaire = physics of the back end of the nuclear fuel cycle), which became PACEN (Physique pour l’Aval du Cycle et production d’Energie Nucléaire = Physics of the back end of the nuclear fuel cycle and production of nuclear energy) in 2006. Research on accelerator driven systems was from the beginning part of this programme. This research is mainly funded by the National Institute for Nuclear end Particle Physics (IN2P3) of CNRS and within the EURATOM European programmes (FP5, 6 and 7). The programme took place in several stages, and covered various scientific fields, benefitting from expertise of CNRS in the field. More specifically, it aimed and still aims to: – Test and verify the feasibility and design of the ADS concept, in terms of neutronics, physics of materials, design of the accelerator and tests of its prototypical components that have been built (or are at present under construction); – Measure and-or improve nuclear data related to radioactive waste transmutation. Today, most of the activities in support to ADS development carried out by CNRS focus on accelerator developments, GUINEVERE (Generator of Uninterrupted Intense NEutron at the lead VEnus REactor) experiment, ADS core studies, deployment scenarios and nuclear data measurements. The CEA R&D programmes on ADS are mainly focused on the European project EUROTRANS of the 6th Framework programme (2005–2010) and continued in the FREYA project of the 7th Framework Programme

  3. Polymorphisms rs12998 and rs5780218 in KiSS1 Suppressor Metastasis Gene in Mexican Patients with Breast Cancer

    Directory of Open Access Journals (Sweden)

    Edhit Guadalupe Cruz Quevedo

    2015-01-01

    Full Text Available Aims. KiSS1 is a metastasis suppressor gene associated with inhibition of cellular chemotaxis and invasion attenuating the metastasis in melanoma and breast cancer cell lines. Along the KiSS-1 gene at least 294 SNPs have been described; however the association of these polymorphisms as genetic markers for metastasis in breast cancer studies has not been investigated. Here we describe two simple PCR-RFLPs protocols to identify the rs5780218 (9DelT and the rs12998 (E20K KiSS1 polymorphisms and the allelic, genotypic, and haplotypic frequencies in Mexican general population (GP and patients with benign breast disease (BBD or breast cancer (BC. Results. The rs5780218 polymorphism was individually associated with breast cancer (P=0.0332 and the rs12998 polymorphism shows statistically significant differences when GP versus case (BC and BBD groups were compared (P<0.0001. The H1 Haplotype (G/- occurred more frequently in BC group (0.4256 whereas H2 haplotype (G/T was the most prevalent in BBD group (0.4674. Conclusions. Our data indicated that the rs5780218 polymorphism individually confers susceptibility for development of breast cancer in Mexican population and a possible role as a genetic marker in breast cancer metastasis for H1 haplotype (Wt/variant in KiSS1 gene must be analyzed in other populations.

  4. THE KISSING BALLOON TECHNIQUE WITH 2 OVER-THE-WIRE BALLOON CATHETERS THROUGH A SINGLE 8-FRENCH GUIDING CATHETER

    NARCIS (Netherlands)

    DENHEIJER, P; BERNINK, PJLM; VANDIJK, RB; TWISK, SPM; LIE, KI

    1991-01-01

    Some of the newer over-the-wire coronary angioplasty catheters have shaft sizes of 3.0 French (F) or less. The inner diameter of modern 8-F guiding catheters is large enough to accommodate two of such balloon catheters. We report a kissing balloon procedure with two over-the-wire catheters through a

  5. Comparative analysis of kisspeptin-immunoreactivity reveals genuine differences in the hypothalamic Kiss1 systems between rats and mice

    DEFF Research Database (Denmark)

    Overgaard, Agnete; Tena-Sempere, Manuel; Franceschini, Isabelle;

    2013-01-01

    kisspeptin-immunoreactivity in both nuclei and both sexes of rats and mice and quantified kisspeptin-immunoreactive nerve fibers. We also determined Kiss1 mRNA levels and measured kisspeptin-immunoreactivity in colchicine pretreated rats. Overall, we find higher levels of kisspeptin-immunoreactivity in the...

  6. SET-Routes programme

    CERN Multimedia

    Marietta Schupp, EMBL Photolab

    2008-01-01

    Dr Sabine Hentze, specialist in human genetics, giving an Insight Lecture entitled "Human Genetics – Diagnostics, Indications and Ethical Issues" on 23 September 2008 at EMBL Heidelberg. Activities in a achool in Budapest during a visit of Angela Bekesi, Ambassadors for the SET-Routes programme.

  7. An economic evaluation of a self-management programme of activity, coping and education for patients with chronic obstructive pulmonary disease.

    Science.gov (United States)

    Dritsaki, Melina; Johnson-Warrington, Vicki; Mitchell, Katy; Singh, Sally; Rees, Karen

    2016-02-01

    The aim was to undertake a cost-utility analysis of a self-management programme of activity, coping and education (SPACE) for chronic obstructive pulmonary disease (COPD). The analysis was conducted alongside a six-month randomized controlled trial in 30 primary care settings. The economic analysis used data from 184 patients with confirmed diagnosis of COPD, forced expiratory volume in one second/forced vital capacity ratio management programme consisting of an education manual (SPACE for COPD) and consultation or usual care. Six-month costs were estimated from the National Health Service and Personal Social Services perspective and quality-adjusted life years (QALYs) were calculated based on patient responses at baseline and six months.The mean difference in costs between usual care and SPACE FOR COPD programme was -£27.18 (95% confidence interval (CI); -£122.59 to £68.25) while mean difference in QALYs was -0.10 (95% CI; -0.17 to -0.02). The results suggest that the intervention is more costly and more effective than usual care. The probability of the intervention being cost-effective was 97% at a threshold of £20,000/QALY gained. We conclude that the SPACE FOR COPD programme is cost-effective compared to usual care.

  8. Co-ordinated research and environmental surveillance programme related to sea disposal of radioactive waste CRESP activity report 1986-1990

    International Nuclear Information System (INIS)

    The Co-ordinated Research and Environmental Surveillance Programme relevant to sea disposal of radioactive waste (CRESP) was created in 1981 in the framework of the 1977 Decision of the OECD Council establishing a Multilateral Consultation and Surveillance Mechanism for Sea Dumping of Radioactive Waste. The main task of CRESP was to set up a site-specific scientific research programme to increase current knowledge of the processes controlling the transfer of radionuclides in the marine environment, so that impact of past dumping could be monitored and future assessments could be based on more accurate and comprehensive scientific data. The CRESP mandate was extended in 1987 to respond to a request from the Paris Commission to include consideration of radioactive discharges in the maritime area covered by the Convention on the Prevention of Marine Pollution from Land-Based Sources. This report summarizes the CRESP activities carried out during the 1986-1990 five year phase. Concerning the review of deep sea results, the report relates progress achieved above the level of knowledge which was available when the present phase of the CRESP programme was decided and which has been taken into account in the 1985 Site Suitability Review. With respect to coastal discharges, it presents a summary of R and D work undertaken by member countries, including those carried out in other programmes such as MARINA. Finally, it makes proposals for future work within CRESP

  9. ADS National Programmes: Germany

    International Nuclear Information System (INIS)

    The German R&D programme for ADS development is related to the partitioning and transmutation of spent fuel. This programme is implemented mainly by the three national research centres belonging to the Helmholtz Association, i.e. Karlsruhe Institute of Technology (KIT), Forschungszentrum Jülich (FZJ) in cooperation with the Technical University of Aachen (RWTH Aachen) and the Helmholtz Zentrum Dresden Rossendorf (HZDR). The main purpose of this R&D programme is the prospect to manage the high level radioactive waste such as to reduce the burden on a final repository. P&T does not eliminate the need for a final repository whatever the strategy, but it allows the reduction of the radio-toxicity associated with radioactive waste, the increase of the repository capacity as a consequence of the reduction of masses to be stored and their associated residual heat load. Different fuel cycle scenarios to implement P&T can be envisaged. These scenarios have been evaluated to identify the impact of P&T on the characteristics, number and deployment pace of the installations of the fuel cycle (reprocessing, fuel fabrication, storage etc). Almost all activities conducted in the R&D programme are embedded in European and international projects and initiatives. In the following more details on the relevant components of the R&D programme are summarized

  10. Policies to Accelerate Fuel, Technology andBehavioural Change in Transport - Results and Success of the Austrian Climate: Active Mobile Programme after the First Seven Years

    International Nuclear Information System (INIS)

    There is plenty of concepts and strategies on almost all administrative levels to reduce carbon emissions and boost energy efficiency in transport. But it usually takes a long time to adapt national and regional legislation to these strategies with considerable loss of valuable time. Furthermore some of the defined measures will never find the necessary ''political will'' for implementation. To bridge this gap Austria's Environmental ministry supported by the Austrian Energy Agency, got into action 2005 and set up an action programme, condensing all so called ''soft'' and ''voluntary'' measures in transport (''mobility management''), that do not necessarily need to wait for legislation or specific administrative framework conditions. In its comprehensive approach - not only transport is targeted, but also buildings, renewables and energy saving - and also in its effects regarding the reduction of GHG emissions, Climate:active and especially climate:active mobile seems to be one-of-a-kind in Europe. Climate-active mobile set-up: free-of-charge consulting programmes addressing specific target groups (companies, cites andmunicipalities, real estate developers, schools andyouth, tourism); a financial support programme with 51 Mio Euro since 2007 for mobility management measures, fleet conversions to low-carbon technologies, work travel plans etc.; an EcoDriving training programme with up to now 20,000 trainees and educating all novice drivers in Austria in a smart driving style; a broad awareness raising campaign; about 2,900 klima:aktiv mobil partners among the target groups implementing sustainable transport measures and therewith reduces more than 530,000 tons of CO2 emissions every year, created or saved 4300 ''green jobs'' in transport and induced ''green'' investments by companies and administrations 7 to 8 times higher as the funding. Climate-active mobile is one of the main drivers in Austria to accelerate fuel, technology andbehavioural change in transport and

  11. The effect of a ten month physical activity intervention programme on body composition of 9-13 year-old boys

    OpenAIRE

    Malan, Dawid Daniel Jacobus; Monyeki, Makama Andries; Toriola, Abel; Van Ridder, Johannes Hendrik; Du Preez, Susanna Maria

    2012-01-01

    Excessive body fat is one of the main contributing factors in many health related health debilitating diseases, such as diabetes, obesity, hypertension and coronary arterioscleroses. The objective of this study was to determine whether a ten month physical activity intervention (PAI) programme could alter the body composition of 9-13 year old boys. A total of 322 (173=experimental group (EG) and 149=control group (CG)) from two primary schools in Gauteng province of South Africa were studied....

  12. Effects of 6-month soccer and traditional physical activity programmes on body composition, cardiometabolic risk factors, inflammatory, oxidative stress markers and cardiorespiratory fitness in obese boys.

    Science.gov (United States)

    Seabra, André; Katzmarzyk, Peter; Carvalho, Maria José; Seabra, Ana; Coelho-E-Silva, Manuel; Abreu, Sandra; Vale, Susana; Póvoas, Susana; Nascimento, Henrique; Belo, Luís; Torres, Sandra; Oliveira, José; Mota, Jorge; Santos-Silva, Alice; Rêgo, Carla; Malina, Robert M

    2016-10-01

    Physical activity is important in obesity prevention, but the effectiveness of different physical activity modalities remains to be determined among children. The main purpose of this study was to compare the effects of a 6-month soccer programme and a traditional physical activity programme on changes in body composition, cardiometabolic risk factors, inflammatory and oxidative markers, cardiorespiratory fitness and perceived psychological status in obese boys. Eighty-eight boys (8-12 years; BMI > +2 standard deviations of WHO reference values) participated in one of three groups: soccer, traditional activity and control. Soccer and traditional activity programmes involved 3 sessions per week for 60-90 min at an average intensity of 70-80% of maximal heart rate. Control group participated in activities of normal daily living. All boys participated in school physical education, two sessions per week of 45-90-min. Measurements were taken at baseline and after 6 months, and included body size and composition, cardiometabolic risk factors, inflammatory and oxidative markers, cardiorespiratory fitness and perceived psychological status. Physical activity and dietary intake were assessed before and immediately following the intervention. The three groups had similar characteristics at baseline. After 6 months, both intervention groups had significantly lower relative fatness (% fat), waist circumference and total cholesterol, and higher cardiorespiratory fitness, self-esteem, perceived physical competence and attraction to physical activity compared with control group. In conclusion, physical activity interventions over 6 months positively influenced several indicators of health status among obese boys. The results also suggested that soccer has the potential as an effective tool for the prevention and reduction of childhood obesity and associated consequences.

  13. Effects of 6-month soccer and traditional physical activity programmes on body composition, cardiometabolic risk factors, inflammatory, oxidative stress markers and cardiorespiratory fitness in obese boys.

    Science.gov (United States)

    Seabra, André; Katzmarzyk, Peter; Carvalho, Maria José; Seabra, Ana; Coelho-E-Silva, Manuel; Abreu, Sandra; Vale, Susana; Póvoas, Susana; Nascimento, Henrique; Belo, Luís; Torres, Sandra; Oliveira, José; Mota, Jorge; Santos-Silva, Alice; Rêgo, Carla; Malina, Robert M

    2016-10-01

    Physical activity is important in obesity prevention, but the effectiveness of different physical activity modalities remains to be determined among children. The main purpose of this study was to compare the effects of a 6-month soccer programme and a traditional physical activity programme on changes in body composition, cardiometabolic risk factors, inflammatory and oxidative markers, cardiorespiratory fitness and perceived psychological status in obese boys. Eighty-eight boys (8-12 years; BMI > +2 standard deviations of WHO reference values) participated in one of three groups: soccer, traditional activity and control. Soccer and traditional activity programmes involved 3 sessions per week for 60-90 min at an average intensity of 70-80% of maximal heart rate. Control group participated in activities of normal daily living. All boys participated in school physical education, two sessions per week of 45-90-min. Measurements were taken at baseline and after 6 months, and included body size and composition, cardiometabolic risk factors, inflammatory and oxidative markers, cardiorespiratory fitness and perceived psychological status. Physical activity and dietary intake were assessed before and immediately following the intervention. The three groups had similar characteristics at baseline. After 6 months, both intervention groups had significantly lower relative fatness (% fat), waist circumference and total cholesterol, and higher cardiorespiratory fitness, self-esteem, perceived physical competence and attraction to physical activity compared with control group. In conclusion, physical activity interventions over 6 months positively influenced several indicators of health status among obese boys. The results also suggested that soccer has the potential as an effective tool for the prevention and reduction of childhood obesity and associated consequences. PMID:26890580

  14. Feasibility and acceptability of a midwife-led intervention programme called 'Eat Well Keep Active' to encourage a healthy lifestyle in pregnancy

    Directory of Open Access Journals (Sweden)

    Warren Lucie

    2012-04-01

    Full Text Available Abstract Background Eating a diet that is high in fat and sugar and having a sedentary lifestyle during pregnancy is understood to increase the risk of excessive gestational weight gain and obesity following the birth of the baby. However, there are no clinical guidelines in the UK on what is considered to be appropriate gestational weight gain. Indeed, clinical recommendations discourage the routine re-weighing of pregnant women, stating instead that women should be advised regarding their diet and activity levels, in order to prevent excessive weight gain. Pregnancy is seen as a time when many women may have an increased motivation to improve their lifestyle behaviours for the benefit of the fetus. However, it is evident that many women have difficulty in both maintaining a healthy balanced diet and remaining active through pregnancy. It would seem that midwives may be ideally placed to assist women to make and maintain healthier lifestyle choices during pregnancy. Methods/design This study will look at the feasibility and acceptability of a newly devised intervention programme called 'Eat Well Keep Active'. Participants will complete a questionnaire prior to the programme to obtain baseline data on food frequency, physical activity and to gauge their perception of personal ability to improve/maintain healthy lifestyle. The programme comprises client centred techniques; motivational interviewing and goal setting delivered early in pregnancy (12-16 weeks with the aim of supporting a healthy well balanced diet and either continuing or commencing appropriate levels of physical activity. Participants will then be followed up six weeks following the intervention with a one-to-one interview, and a further brief questionnaire. The interview will provide preliminary data regarding perceived effectiveness and acceptability of the 'Eat Well Keep Active' programme whilst the questionnaire will provide data regarding changes in the confidence of

  15. IDIOPATHIC THORACO SCOLIOSIS TREATMENT USING A COMBINATION OF DOCUMENTATION BASED CARE (DBC BACK ACTIVE RECONDITIONING PROGRAMME AND SCHROTH METHODS: A PROSPECTIVE CASE STUDY

    Directory of Open Access Journals (Sweden)

    Ganesan Kathiresan

    2013-10-01

    Full Text Available reconditioning programme and Schroth methods to lessen the curvature allied with idiopathic Thoracicscoliosis.ResearchDesign: Sampling-An 18 years old female, single case study,Setting-DBC Kuching Active rehabilitationcentre, Malaysia.Duration of the study-20 weeks,Outcome measures-A base line and follow-up outcomemeasures includes Borg pain scale, Functional Rating Index, Balance test, and Radiographic analysis.Interventions-Document Based Care (DBC Back active reconditioning programme and Schroth methodsConclusion-The combination of the Document Based Care (DBC Back active reconditioning programme andSchroth methods seemed to be effective at reducing a Thoracic dextroscoliosis by about 14° (50% andLumbarLevoscoliosis by about 7° (25%, Short form (SF-36 showed improvement inQuality of life,balance time on theBalance board improved to 52 seconds and Borg pain scale rated 8/10 at the onset of care, dropped to a 1/10after 20 weeks, in this single case study. The positive outcomes of this practice validate a policyof offeringconservative treatment as an alternative to Thoracic scoliosis patients, including those for whom surgery isdiscussed

  16. Development and implementation of a lifestyle intervention to promote physical activity and healthy diet in the Dutch general practice setting: the BeweegKuur programme

    Directory of Open Access Journals (Sweden)

    de Vries Nanne K

    2010-05-01

    Full Text Available Abstract Background The number of patients with diabetes is increasing. BeweegKuur (Dutch for 'Exercise Therapy' is a Dutch lifestyle intervention which aims to effectively and feasibly promote physical activity and better dietary behaviour in primary health care to prevent diabetes. Methods The goal of this paper is to present the development process and the contents of the intervention, using a model of systematic health promotion planning. The intervention consists of a 1-year programme for diabetic and prediabetic patients. Patients are referred by their general practitioner (GP to a lifestyle advisor (LSA, usually the practice nurse or a physiotherapist. Based on specific inclusion criteria and in close collaboration with the patient, an individual exercise programme is designed and supervised by the LSA. This programme can be attended at existing local exercise facilities or (temporarily under the supervision of a specialized exercise coach or physiotherapist. All participants are also referred to a dietician and receive diet-related group education. In the first pilot year (2008, the BeweegKuur programme was implemented in 7 regions in the Netherlands (19 GP practices and health centres, while 14 regions (41 GP practices and health centres participated during the second year. The aim is to implement BeweegKuur in all regions of the Netherlands by 2012. Discussion The BeweegKuur programme was systematically developed in an evidence- and practice-based process. Formative monitoring studies and (controlled effectiveness studies are needed to examine the diffusion process and the effectiveness and cost-effectiveness of the intervention.

  17. Re-thinking global health sector efforts for HIV and tuberculosis epidemic control: promoting integration of programme activities within a strengthened health system

    Directory of Open Access Journals (Sweden)

    Maher Dermot

    2010-07-01

    Full Text Available Abstract Background The global financial crisis threatens global health, particularly exacerbating diseases of inequality, e.g. HIV/AIDS, and diseases of poverty, e.g. tuberculosis. The aim of this paper is to reconsider established practices and policies for HIV and tuberculosis epidemic control, aiming at delivering better results and value for money. This may be achieved by promoting greater integration of HIV and tuberculosis control programme activities within a strengthened health system. Discussion HIV and tuberculosis share many similarities in terms of their disease burden and the recommended stratagems for their control. HIV and tuberculosis programmes implement similar sorts of control activities, e.g. case finding and treatment, which depend for success on generic health system issues, including vital registration, drug procurement and supply, laboratory network, human resources, and financing. However, the current health system approach to HIV and tuberculosis control often involves separate specialised services. Despite some recent progress, collaboration between the programmes remains inadequate, progress in obtaining synergies has been slow, and results remain far below those needed to achieve universal access to key interventions. A fundamental re-think of the current strategic approach involves promoting integrated delivery of HIV and tuberculosis programme activities as part of strengthened general health services: epidemiological surveillance, programme monitoring and evaluation, community awareness of health-seeking behavior, risk behaviour modification, infection control, treatment scale-up (first-line treatment regimens, drug-resistance surveillance, containing and countering drug-resistance (second-line treatment regimens, research and development, global advocacy and global partnership. Health agencies should review policies and progress in HIV and tuberculosis epidemic control, learn mutual lessons for policy

  18. Project Energize: whole-region primary school nutrition and physical activity programme; evaluation of body size and fitness 5 years after the randomised controlled trial.

    Science.gov (United States)

    Rush, Elaine; McLennan, Stephanie; Obolonkin, Victor; Vandal, Alain C; Hamlin, Michael; Simmons, David; Graham, David

    2014-01-28

    Project Energize, a region-wide whole-school nutrition and physical activity programme, commenced as a randomised controlled trial (RCT) in the period 2004-6 in 124 schools in Waikato, New Zealand. In 2007, sixty-two control schools were engaged in the programme, and by 2011, all but two of the 235 schools in the region were engaged. Energizers (trained nutrition and physical activity specialists) work with eight to twelve schools each to achieve the goals of the programme, which are based on healthier eating and enhanced physical activity. In 2011, indices of obesity and physical fitness of 2474 younger (7·58 (sd 0·57) years) and 2330 older (10·30 (sd 0·51) years) children attending 193 of the 235 primary schools were compared with historical measurements. After adjusting for age, sex, ethnicity, socio-economic status (SES) and school cluster effects, the combined prevalence of obesity and overweight among younger and older children in 2011 was lower by 31 and 15 %, respectively, than that among 'unEnergized' children in the 2004 to 2006 RCT. Similarly, BMI was lower by 3·0 % (95 % CI - 5·8, - 1·3) and 2·4 % (95 % CI - 4·3, - 0·5). Physical fitness (time taken to complete a 550 m run) was significantly higher in the Energized children (13·7 and 11·3 %, respectively) than in a group of similarly aged children from another region. These effects were observed for boys and girls, both indigenous Māori and non-Māori children, and across SES. The long-term regional commitment to the Energize programme in schools may potentially lead to a secular reduction in the prevalence of overweight and obesity and gains in physical fitness, which may reduce the risk of developing obesity and type 2 diabetes. PMID:23867069

  19. Kissing Cousins

    Science.gov (United States)

    Wyatt, Neal

    2010-01-01

    In the library world, there seems to be a fundamental conflict between reference and readers' advisory (RA). But in fact, the two are similar in approach, an insight that goes back to James Wyer's 1930 "Reference Work: A Textbook for Students of Library Work and Librarians." It defined the reference librarian as a mediator of information,…

  20. The ProActive trial protocol – a randomised controlled trial of the efficacy of a family-based, domiciliary intervention programme to increase physical activity among individuals at high risk of diabetes [ISRCTN61323766

    Directory of Open Access Journals (Sweden)

    Ekelund Ulf

    2004-10-01

    Full Text Available Abstract Background Increasing prevalence of obesity and disorders associated with sedentary living constitute a major global public health problem. While previous evaluations of interventions to increase physical activity have involved communities or individuals with established disease, less attention has been given to interventions for individuals at risk of disease. Methods/design ProActive aims to evaluate the efficacy of a theoretical, evidence- and family-based intervention programme to increase physical activity in a sedentary population, defined as being at-risk through having a parental family history of diabetes. Primary care diabetes or family history registers were used to recruit 365 individuals aged 30–50 years, screened for activity level. Participants were assigned by central randomisation to three intervention programmes: brief written advice (comparison group, or a psychologically based behavioural change programme, delivered either by telephone (distance group or face-to-face in the family home over one year. The protocol-driven intervention programme is delivered by trained facilitators, and aims to support increases in physical activity through the introduction and facilitation of a range of self-regulatory skills (e.g. goal setting. The primary outcome is daytime energy expenditure and its ratio to resting energy expenditure, measured at baseline and one year using individually calibrated heart rate monitoring. Secondary measures include self-report of individual and family activity, psychological mediators of behaviour change, physiological and biochemical correlates, acceptability, and costs, measured at baseline, six months and one year. The primary intention to treat analysis will compare groups at one-year post randomisation. Estimation of the impact on diabetes incidence will be modelled using data from a parallel ten-year cohort study using similar measures. Discussion ProActive is the first efficacy trial of an

  1. VizieR Online Data Catalog: Metal abundances of KISS galaxies. V. (Hirschauer+, 2015)

    Science.gov (United States)

    Hirschauer, A. S.; Salzer, J. J.; Bresolin, F.; Saviane, I.; Yegorova, I.

    2016-01-01

    Our spectroscopic targets for this project were potentially metal-rich galaxies identified by KPNO International Spectroscopic Survey (KISS; Salzer et al., 2000AJ....120...80S). KISS used low-dispersion objective-prism spectra to identify emission-line galaxy (ELG) candidates via detection of line emission in galaxies with redshifts of less than 0.095. The "red" survey (Salzer et al. 2001, cat. J/AJ/121/66; Gronwall et al. 2004, cat. J/AJ/127/1943; Jangren et al. 2005, cat. J/AJ/130/2571) cataloged objects by means of the Hα line, while the "blue" survey (Salzer et al. 2002, cat. J/AJ/123/1292) distinguished objects through strong [OIII]λ5007 line emission. The 15 galaxies discussed in this paper were chosen from the KISS Hα-selected catalog. Spectra of 15 KISS ELGs were obtained using the Keck I 10m telescope on 2006 May 25 with the Low-Resolution Imaging Spectrometer (LRIS), a double spectrograph that includes a dichroic that directs light toward a red and a blue side. The use of two distinct dispersion elements and cameras enables simultaneous spectral coverage spanning from ~3000 to ~10000Å with good dispersion. Blue side exposures used the 600/400 grism, with a dispersion of 0.63Å/pixel, a resolution of ~6Å, and wavelength coverage between ~3000 and ~5600Å. Red side exposures used the 900/5500 grating, with a dispersion of 0.53Å/pixel, a resolution of ~3Å, and wavelength coverage between ~5700 and ~7300Å. Each galaxy was first observed using the blue and red sides simultaneously to determine if further observations would yield usable spectra. If the raw spectra were of substantially high quality, the red side grating was switched to observe near-infrared (NIR) lines. This was completed for ten of the fifteen galaxies. For NIR exposures, the red side was switched to the 400/8500 grating, with a dispersion of 1.16Å/pixel, a resolution of ~6Å, and wavelength coverage between ~6300 and ~10000Å in order to observe the NIR [SIII] nebular lines at λ9069

  2. Investigations on tunneling and kissing bond defects in FSW joints for dissimilar aluminum alloys

    Energy Technology Data Exchange (ETDEWEB)

    Khan, Noor Zaman, E-mail: noor_0315@yahoo.com [Department of Mechanical Engineering, Jamia Millia Islamia (A Central University), New Delhi (India); Siddiquee, Arshad Noor; Khan, Zahid A. [Department of Mechanical Engineering, Jamia Millia Islamia (A Central University), New Delhi (India); Shihab, Suha K. [Department of Mechanical Engineering, Engineering College, Diyala University, Diyala (Iraq)

    2015-11-05

    In this paper an attempt has been made to investigate the effect of two Friction Stir Welding (FSW) parameters i.e. tool pin offset and tool plunge depth on the formation of defects such as tunnel (tunneling defect) and kissing bond (KB) during welding of dissimilar aluminum alloys. 4.75 mm thick plates of AA5083-H116 and AA6063-T6 were welded using a novel work-fixture developed in-house which, apart from clamping the plated also imparted continuous variation of offset on both side of the faying line. The tunneling defect was modeled as a function of offset and plunge depth. The welds were characterised using optical microscopy (OM), scanning electron microscopy (SEM) and mechanical testing. The causes of such defects have been analyzed and discussed and recommendations have been made to prevent their occurrence. The findings of the study have revealed that the tunneling defects are formed at all offset (including zero offset) values towards stronger material (advancing side). And the cross-section of the tunnel varied with the amount of offset. Further, KBs are formed at the interface for all pin offset values except 0.5 mm towards weaker material and high plunge depth resulting in the poor mechanical properties. - Highlights: • Two dissimilar aluminum alloys are welded using FSW. • Formation of kissing bond and tunneling defects are investigated. • Defects are formed at pin offsets towards stronger material and also without offset. • The size of tunnel reduces significantly by increasing the plunge depth. • Tool pin offset towards weaker material prevent tunneling defects.

  3. Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat.

    Science.gov (United States)

    Navarro, V M; Castellano, J M; Fernández-Fernández, R; Tovar, S; Roa, J; Mayen, A; Barreiro, M L; Casanueva, F F; Aguilar, E; Dieguez, C; Pinilla, L; Tena-Sempere, M

    2005-04-01

    KiSS-1 was originally identified as a metastasis suppressor gene encoding an array of structurally related peptides, namely kisspeptins, which acting through the G protein-coupled receptor GPR54 are able to inhibit tumor progression. Unexpectedly, a reproductive facet of this newly discovered system has recently arisen, and characterization of the role of the KiSS-1/GPR54 system in the neuroendocrine control of gonadotropin secretion has been initiated. However, such studies have been so far mostly restricted to LH, and very little is known about the actual contribution of this system in the regulation of FSH release. To address this issue, the effects of KiSS-1 peptide on FSH secretion were monitored in vivo and in vitro under different experimental conditions. Intracerebroventricular administration of KiSS-1 peptide significantly stimulated FSH secretion in prepubertal and adult rats. Yet, dose-response analyses in vivo demonstrated an ED(50) value for the FSH-releasing effects of KiSS-1 of 400 pmol, i.e. approximately 100-fold higher than that of LH. In addition, systemic (ip and iv) injection of KiSS-1 significantly stimulated FSH secretion in vivo. However, KiSS-1 failed to elicit basal FSH release directly at the pituitary level, although it moderately enhanced GnRH-stimulated FSH secretion in vitro. Finally, mechanistic studies revealed that the ability of KiSS-1 to elicit FSH secretion was abolished by the blockade of endogenous GnRH actions, but it was persistently observed in different models of leptin insufficiency and after blockade of endogenous excitatory amino acid and nitric oxide pathways, i.e. relevant signals in the neuroendocrine control of gonadotropin secretion. In summary, our results extend previous recent observations on the role of KiSS-1 in the control of LH secretion and provide solid evidence for a stimulatory effect of KiSS-1 on FSH release, acting at central level. Overall, it is proposed that the KiSS-1/GPR54 system is a novel

  4. The effects of a home-based arm ergometry exercise programme on physical fitness, fatigue and activity in polio survivors: protocol for a randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Murray Deirdre

    2012-12-01

    Full Text Available Abstract Background Many Polio survivors have reduced mobility, pain and fatigue, which make access to conventional forms of aerobic exercise difficult. Inactivity leads to increased risk of health problems, many of which are prevalent among Polio survivors. Aerobic exercise programmes in Polio survivors should utilise stable muscle groups and should be designed to minimise exacerbation of pain and fatigue. A home-based arm ergometry aerobic exercise programme may represent an affordable and accessible exercise modality, incorporating exercise prescription principles in this group. Methods/design This is a prospective, single blinded, randomised controlled trial. There are two arms; exercise intervention using arm ergometers and control. Polio survivors meeting eligibility criteria will be recruited and randomly allocated to intervention or control groups. Participants allocated to the intervention group will receive a small arm ergometer and a polar heart rate monitor. They will carry out a home-based moderate intensity (50-70% HRMax aerobic exercise programme for eight weeks, following instruction by the treating physiotherapist. Assessments will occur at baseline and after eight weeks and will include tests of physical fitness, activity, energy cost of walking, fatigue and quality of life. Clinically feasible assessment tools including the Six Minute Arm Test, the Physical Activity Scale for People with Physical Disabilities questionnaire, the Physiological Cost Index, Fatigue Severity Scale and the SF-36v2 will be utilised. Discussion The efficacy of a home-based arm ergometry programme in Polio survivors will be examined. No previous trial has examined such a programme using a wide range of outcome measures pertinent to Polio survivors. This study will provide new information on the impact of arm ergometry on physical fitness, activity, body composition, fatigue, pain, muscle strength, and health related quality of life. Also, the study

  5. Referral from primary care to a physical activity programme: establishing long-term adherence? A randomized controlled trial. Rationale and study design

    Directory of Open Access Journals (Sweden)

    Puig-Ribera Anna

    2009-01-01

    Full Text Available Abstract Background Declining physical activity is associated with a rising burden of global disease. There is little evidence about effective ways to increase adherence to physical activity. Therefore, interventions are needed that produce sustained increases in adherence to physical activity and are cost-effective. The purpose is to assess the effectiveness of a primary care physical activity intervention in increasing adherence to physical activity in the general population seen in primary care. Method and design Randomized controlled trial with systematic random sampling. A total of 424 subjects of both sexes will participate; all will be over the age of 18 with a low level of physical activity (according to the International Physical Activity Questionnaire, IPAQ, self-employed and from 9 Primary Healthcare Centres (PHC. They will volunteer to participate in a physical activity programme during 3 months (24 sessions; 2 sessions a week, 60 minutes per session. Participants from each PHC will be randomly allocated to an intervention (IG and control group (CG. The following parameters will be assessed pre and post intervention in both groups: (1 health-related quality of life (SF-12, (2 physical activity stage of change (Prochaska's stages of change, (3 level of physical activity (IPAQ-short version, (4 change in perception of health (vignettes from the Cooperative World Organization of National Colleges, Academies, and Academic Associations of Family Physicians, COOP/WONCA, (5 level of social support for the physical activity practice (Social Support for Physical Activity Scale, SSPAS, and (6 control based on analysis (HDL, LDL and glycated haemoglobin. Participants' frequency of visits to the PHC will be registered over the six months before and after the programme. There will be a follow up in a face to face interview three, six and twelve months after the programme, with the reduced version of IPAQ, SF-12, SSPAS, and Prochaska's stages

  6. A theory evaluation of an induction programme

    Directory of Open Access Journals (Sweden)

    Kenrick Hendricks

    2012-07-01

    Full Text Available Orientation: An induction programme is commonly used to help new employees understand their job within the organisation. Research purpose: The main aim of this study was to examine whether or not the programme theory of an induction programme was plausible and would lead to the intended outcomes as described by the programme manager.Motivation for the study: Induction training is one of the most common training programmes in an organisation. However, there is little research to evaluate whether or not the activities of an induction programme will lead to the intended outcomes of such a programme.Research design, approach and method: This theory evaluation used a descriptive design. One hundred and thirteen employees of a media company completed a ten-item, five-point Likert scale which measured their perceptions of the programme’s outcome, identification with the organisation and intentions to stay with the organisation.Main findings: From this theory evaluation it was apparent that an induction programme based on an implausible programme theory could be problematic. An implausible programme theory affects the design of the programme activities and unsuitable activities may not deliver the desired outcomes.Practical/managerial implications: The intention of the evaluation is to guide human resource managers through a process of replacing an implausible programme theory with one that is plausible, and which ensures better alignment of programme activities and outcomes.Contribution/value-add: The evaluators showed how a plausible programme theory could improve programme design. This redesigned induction programme may lead to benefits, such as staff retention and company identification, rather than the vague assumption that it has been conforming to a legal obligation.

  7. ISOLDE PROGRAMME

    CERN Multimedia

    Fedosseev, V; Lynch, K M; Grob, L K; Herfurth, F; Scheidenberger, C; Geppert, C; Gorges, C; Ratajczyk, T; Vogel, S; Munch, M K; Nieminen, P; Pakarinen, J J A; Lecesne, N; Bouzomita, H; Grinyer, J; Marques moreno, F M; Parlog, M; Pedroza, J; Ghetta, V; Lozeva, R; Guillemaud mueller, D S; Cottereau, E; Cheikh mhamed, M; Tusseau nenez, S; Tungate, G; Walker, P M; Smith, A G; Fitzpatrick, C; Dominik, W M; Karny, M; Ciemny, A A; Nyman, G H; Thies, R M A; Lindberg, S K G; Langouche, G F; Delaure, B J P; Mayet, P; Ory, G T; Kesteloot, N J K; Papuga, J; Dehairs, M H R; Callens, M; Domnanich, K A; Richter, D; Lutter, R J; Wiehr, S; Tengblad, O; Nacher gonzalez, E; Jungclaus, A; Ribeiro jimenez, G; Marroquin alonso, I; Cal gonzalez, J; Paziy, V; Salsac, M; Murphy, C; Podolyak, Z F; Bajoga, A D; Butler, P; Pritchard, A; Steer, A N; Fox, S P; Wadsworth, B A; Truesdale, V L; Al monthery, M; Hass, M; Guttormsen, M S; Badea, M N; Calinescu, S; Cederkall, J A; Zemlyanoy, S; Golovkov, M; Wu, C; Harrichunder, S; Ncube, M; Gerten, R F; Lehnert, J; Gladnishki, K A; Pospisil, S; Datta pramanik, U; Benzoni, G; Fedorov, D; Molkanov, P; Pfeiffer, B; Griesel, T; Wehner, L W; Mikkelsen, M; Recchia, F; Smith, J F; Kelly, C M; De melo bandeira tavares, P M; Vieira, J M; Martins da silva, M A; Lima lopes, A M; Mader, J; Kessler, P; Laurent, B G; Schweikhard, L C; Marx, G H; Kulczycka, E; Komorowska, M; Da silva, M F; Goncalves marques, C P; Baptista peres, M A; Welander, J E; Coeck, S; Ryssens, W A M; Knoops, G; Vanbuel, J; Reiter, P; Miller, C; Martin sanchez-cano, D; Wiens, A; Blazhev, A A; Braun, N; Cappellazzo, M V; Birkenbach, B; Gerst, R; Dannhoff, M F; Sithole, M J; Bilgier, B; Nardelli, S; Vetter, U; Araujo mendes, C M; Valencia marin, E; Pantea, E; Hessberger, F P; Leduc, A J; Mitsuoka, S; Carbonari, A W; Buchegger, F J; Garzon camacho, A; Stachura, M K; Stora, T; Marsh, B A; Thiboud, J A; Antalic, S; Stahl, C; Bauer, C; Thurauf, M; Maass, B; Sturm, S; Boehm, C; Ways, M; Heylen, H; Riisager, K; Ruotsalainen, P A; Bastin, B; Duval, F T; Penessot, G; Flechard, X D; Desrues, P; Giovinazzo, J; Blank, B A; Kurtukian nieto, T; Ascher, P E L; Roccia, S; Matea, I; Croizet, H A G; Bonnin, C M; Morfouace, P; Smith, A J; Guin, R; Banerjee, D; Ohtsubo, T; Zhukov, M V; Tengborn, E A; Dessagne, P; Juscamaita vivanco, Y; De rydt, M A E; Vermaelen, P; Monten, R; Yang, X; De coster, A; Kruecken, R; Nowak, A K; Cano ott, D; Murphy, A S J; Shand, C M; Regan, P H; Jones, G D; Herzberg, R; Ikin, P; Davies, P J; Napoli, D R; Scarel, G; Larsen, A; Tornyi, T G; Pascu, S G; Stroe, L; Toma, S; Jansson, K; Dronjak fahlander, M; Krupko, S; Hurst, A M; Veskovic, M; Nikolov, J; Sibanda, W N; Rocchini, M; Deicher, M; Wichert, T; Wolf, E; Kronenberg, J; Helmke, A; Meliani, Z; Ivanov, V S; Kuti, I; Halasz, Z; Henry, M O; Bras de sequeira amaral, V; Espirito santo, F; Carvalho teixeira, R C; Rosendahl, S; Speidel, K; Agarwal, I; Faul, T; Kownacki, J M; Martins correia, J G; Lorenz, K; Costa miranda, S M; Granadeiro costa, A R; Da costa pereira, L M; Keupers, M; Stukken, R; Wursten, E J; Kotthaus, T; Pfeiffer, M; Stegemann, S T; Gironi, L; Cakirli, R B; Jensen, A; Romstedt, F; Constantino silva furtado, I; Heredia cardona, J A; Jordan martin, M D; Montaner piza, A; Plewinski, F; Mesli, A; Pichard, A; Fallis starhunter, J P; Voulot, D; Mrazek, J; Ugryumov, V; Savreux, R P; Kojouharov, I M; Stegmann, R; Fitting, J; Lauer, M; Kirsebom, O S; Jensen, K L; Jokinen, A; Rahkila, P J; Hager, U D K; Dubois, M; Orr, N A; Fabian, X; Huikari, J E; Goigoux, T; Magron, C; Zakari, A A; Maietta, M; Bachelet, C E M; Roussiere, B; Li, R; Foster, R M; Mertzimekis, T; Gislason, H P; Shayestehaminzadeh, S; Qi, B; Mukai, M; Watanabe, Y; Willmann, L; Kurcewicz, W; Wimmer, K; Meisel, Z P; Lievens, P; Neyens, G; Darby, I G; Descamps, B O; Ceruti, S; Bunka, M; Vermeulen, C; Podadera aliseda, I; Alcorta moreno, M; Pesudo fortes, V; Algora, A; Zielinska, M; Korten, W; Wang, C H; Lotay, G J; Mason, P; Rice, S J; Willenegger, L M; Judson, D S; Revill, J P; Andreev, A; Yavuzkanat, N; Kumar, V; Zamfir, N - V; Deleanu, D; Jeppesen, H B; Pain, S D; Stracener, D W; Matousek, V; Venhart, M; Birova, M; Li, X; Stuchbery, A E; Lellep, G M; Chakraborty, S; Leoni, S; Chupp, T; Yilmaz, C; Severin, G; Garcia ramos, J E; Hadinia, B; Mc glynn, E; Monteiro de sena silvares de carvalho, I; Friedag, P; Koos, V; Meot, V H; Pauwels, D B; Jancso, A; Srebrny, J; Alves, E J; David bosne, E; Dexters, W M M; Velten, P; Kalkuehler, M; Albers, M; Bharuth-ram, K; Akkus, B; Hemmingsen, L B S; Pedersen, J T; Dos santos redondo, L M; Rubio barroso, B; Kozlov, V; Mokhles gerami, A; Bernardo da silva, E; Unzueta solozabal, I; Schell, J; Szybowicz, M; Lassen, J; Johnston, K; Miyazaki, A; Macko, M; Coquard, L; Bloch, T P; Bonig, E S; Ignatov, A; Paschalis, S; Schilling, M; Habermann, T; Von hahn, R; Minaya ramirez, E E; Manea, V; Karthein, J; Moore, I D; Wang, Y; Saastamoinen, A J; Grahn, T; Herzan, A; Stolze, S M; Clement, E; Dijon, A; Shornikov, A; Lienard, E; Gibelin, J D; Pain, C; Canchel, G; Simpson, G S; Latrasse, L P; Forest, D H; Billowes, J; Flanagan, K; Strashnov, I; Binnersley, C L; Simpson, J; Morrall, P S; Grant, A F; Charisopoulos, S; Lagogiannis, A; Bhattacharya, C; Olafsson, S; Tornqvist, H T; Heinz, A M; White iv, E R; Vermote, S L; Courtin, S; Marechal, F; Randisi, G; Rajabali, M M; Lannoo, B J M; Frederickx, R; De coster, T J C; Roovers, N; De lemos lima, T A; Haller, S; Rizzi, M; Reichert, S B; Bonn, J; Thirolf, P G; Garcia rios, A R; Gugliermina, V M; Cubero campos, M A; Sanchez tembleque, V; Benito garcia, J; Senoville, M; Mountford, D J; Gelletly, W; Alharbi, T S T; Wilson, E; Rigby, S V; Andreoiu, C; Paul, E S; O'neill, G G; Harkness, L J; Wraith, C; Van esbroeck, K; Wadsworth, R; Cubiss, J G; Doherty, D T; Harding, R; Vaintraub, S; Mandal, S K; Hadynska-klek, K; Scarpa, D; Hoff, P; Syed naeemul, H; Borcea, R; Balabanski, D L; Marginean, R; Rotaru, F; Rudolph, D; Fahlander, C H; Chudoba, V; Naidoo, D; Veselsky, M; Kliman, J; Raisanen, J A; Dietrich, M; Maung maung than, M M T; Reed, M W; Danchev, M T; Ray, J; Roy, M; Hammen, M; Capponi, L; Veghne csatlos, M M; Fryar, J; Da silva fenta, A E; Mirzadeh vaghefi, S P; Trindade pereira, A M; De pinho oliveira, G N; Bakenecker, A; Tramm, C; Germic, V; Morel, P A; Kowalczyk, M; Matejska-minda, M; Ringvall moberg, A; Kana, T; Vermeeren, B R M; Dockx, K; Mantovan, R; Fransen, C H; Radeck, F; Schneiders, D W; Steinbach, T; Vibenholt, J E; Magnussen, M J; Stevnhoved, H M; Comas lijachev, V; Dasenbrock-gammon, N M; Perkowski, J; Matveev, Y; Garcia borge, M J; Molholt, T E; Srnka, D; Dlouhy, Z; Beck, D; Homm, I; Eliseev, S; Blaum, K; Probst, M B; Kaiser, C J; Papadakis, F; Peura, P J; Greenlees, P T; Auranen, K; Delahaye, P; Traykov, E K; Perez loureiro, D; Mery, A A; Couratin, C; Tsekhanovich, I; Lunney, D; Gaulard, C V; Althubiti, N A S; Mottram, A D; Das, S K; Van de walle, J; Mazzocchi, C; Jonson, B N G; Woehr, A; Lesher, S R; Zuber, K T; Koudriavtsev, I; De witte, H J; Van den bergh, P A M; Raabe, R; Depuydt, M J F; Radulov, D P; Elseviers, J; Reynders, K L T; Sels, S M C; Verlinde, M; Delombaerde, L; De maesschalck, D; Tarasava, K; Gernhaeuser, R A; Weinzierl, W; Wendt, K; Achtzehn, T; Gottwald, T; Schug, M; Rossel, R E; Dominguez reyes, R R; Briz monago, J A; Koester, U H; Bunce, M R; Bowry, M D; Nakhostin, M; Shearman, R; Cresswell, J R; Joss, D T; Gredley, A; Groombridge, D; Siem, S; Weterings, J A; Renstrom, T; Szpak, B T; Luczkowski, M J; Ghita, D; Bezbakh, A; Bollmann, J; Bhattacharya, P; Roy, S; Rahaman, M A; Wlodarski, T; Carvalho soares, J; Barzakh, A; Werner, V R; Schertz, F; Froemmgen, N E; Liberati, V; Foy, B E; Weinheimer, C P; Zboril, M; Figuera, P; Simon, R E; Popescu, L A; Czosnyka, T; Miranda jana, P A; Buescher, J S L; Plociennik, W A; Ruchowska, E E; Chiara, C J; Eberth, J H; Thomas, T; Thole, P; Queiser, M T; Lo bianco, G; D'amico, F; Muller, S; Sanchez alarcon, R M; Tain enriquez, J L; Orrigo, S E A; Orlandi, R; Plazaola muguruza, F C; Lepareur, N G; Wildner, E; Kowalska, M; Malbrunot, S; Slezak, M; Roeckl, E; Schrieder, G H; Ilieva, S K; Koenig, K L; Amoretti, M A; Lommen, J M; Fynbo, H O U; Weyer, G O P; Koldste, G T; Madsboll, K; Jensen, J H; Nieminen, A M; Reponen, M; Villari, A; Thomas, J; Saint-laurent, M; Sorlin, O H; Carniol, B; Pereira lopez, J; Grevy, S; Plaisir, C; Marie-jeanne, M J; Georgiev, G P; Etile, A M; Le blanc, F M; Verney, D; Stefan, G I; Assie, M; Suzuki, D; Guillot, J; Vazquez rodriguez, L; Campbell, P; Deacon, A N; Ware, T; Flueras, A; Xie, L; Banerjee, K; Piersa, M; Johansson, H T; Schwarz, S; Welker, A; Krauth, M R; Perrot, F; Aumont, J; Sferrazza, M; Van duppen, P L E; Versyck, S; Dehaes, J; Bree, N C F; Neyskens, P; Martinez palenzuela, Y; De groote, R P; Carlier, L M F; De schepper, S; Dewolf, K W A; Kabir, L R; Garcia ruiz, R F; Khodery ahmad, M A; Zadvornaya, A; Xu, Z; Smolders, P; Krastev, P; Rapisarda, E; Reber, J A; Mattolat, C F; Raeder, S; Habs, D; Martinez perez, T; Fraile prieto, L M; Vidal, M; Perez liva, M; Calvo portela, P; Ulla pedrera, F J; Domingo pardo, C; Morales lopez, A I; Wood, R T; Lalkovski, S; Page, R; Petri, M; Barton, C J; Nichols, A J; Vermeulen, M J; Bloor, D M; Henderson, J; Wilson, G L; De angelis, G; Buerger, A; Klintefjord, M L; Fornal, B A; Marginean, R; Sava, T; Suvaila, R; Lica, R; Costache, C; Mihai, R; Ionescu, A; Baeck, T M; Masenda, H; Sedlak, M; Koskelo, O K; Kyaw myat, K M; Ganguly, B; Goncalves marques, J; Cardoso, S; Seliverstov, M; Niessen, B D; Gutt, L E; Chapman, R; Spagnoletti, P N; Lopes, C; De oliveira amorim, C; Batista lopes, C M; Araujo, J; Schielke, S J; Daugas, J R; Gaudefroy, L; Chevrier, R; Szunyogh, D M; Napiorkowski, P J; Wrzosek-lipska, K; Wahl, U; Catarino, N; Pereira carvalho alves de sequeira, M; Decoster, S J; Porobic, T; Walters, W; Hess, H E; Holler, A; Bettermann, L; Geibel, K; Taprogge, J; Lewandowski, L T N; Manchado de sola, F; Das gupta, S; Thulstrup, P W; Heinz, U; Neidherr, D M; Gumenyuk, O; Peaker, A R; Wakabayashi, Y; Roder, J; Abrahams, K J; Mach, H A; Souza ribeiro junior, I; He, J; Giles, T J; Dorsival, A; Kalaninova, Z; Venos, D; Kraemer, J; Saha, S; Neugart, R; Eronen, T O; Kreim, K D; Heck, M K; Goncharov, M; Julin, R J; Jakobsson, E H U; Eleon, C; Achouri, N L; Fontbonne, C M; Alfaurt, P; Kusoglu, A; Wilkins, S G; Brown, A R; Imai, N; Pomorski, M J; Janiak, L; Nilsson, T; Stroke, H H; Stanja, J; Dangelser, E; Heenen, P; Mallion, S N; Diriken, J V J; Ghys, L H L; Khamehchi, M A; Van beveren, C; Gins, W A M; Bouma, J T; Mcnulty, J F; Berger, C J; Ohlert, C M; Schwerdtfeger, W; Becerril reyes, A D; Perea martinez, A; Martinez perez, M C; Margerin, V; Rudigier, M; Alexander, T D; Patel, Z V; Hammond, N; Wearing, F; Patel, A; Jenkins, D G; Debernardi, A; Giacoppo, F; Tveten, G M; Krolas, W A; Stanoiu, M A; Rickert, E U; Ter-akopian, G; Cline, D; Riihimaeki, I A; Simon, K D; Wagner, F E; Turker, M; Neef, M H; Jakubek, J; Vagena, E; Bottoni, S; Nishimura, K; Correia, J; Rodrigues valdrez, C J; Ostrowski, A N; Hallmann, O; Scheck, M; Wady, P T; Lane, J; Krasznahorkay, A J; Kunne sohler, D; Meaney, A J; Baptista barbosa, M; Hochschulz, F; Roig, O; Houngbo, D; Behan, C C; Kargoll, S; Kemnitz, S; Redondo cubero, A; Dirkx, D; Tallarida, G; Kaczarowski, R; Finke, F; Linnemann, A; Altenkirch, R; Saed-samii, N; Ansari, S H; Dlamini, W B; Adoons, V N; Ronning, C R; Guadilla gomez, V; Herlert, A J; Judge, S M; Catherall, R; Lettry, J; Lindroos, M; Wenander, F J C; Madurga flores, M; Zakoucky, D; Catchen, G L; Noertershaeuser, W; Kroell, T; Leske, J; Shubina, D; Murray, I M; Pancin, J; Delaunay, F; Poincheval, J J L; Audirac, L L; Gerbaux, M T; Aouadi, M; Sole, P G P; Fallot, M P; Onillon, A; Duchemin, C; Formento cavaier, R; Audi, G; Lau, C; Martin, J A; Barre, N H; Berry, T A; Procter, T J; Farooq-smith, G J; Bladen, L K; Axiotis, M; Muto, S; Jeong, S C; Hirayama, Y; Korgul, A B; Minamisono, K; Bingham, C R; Aprahamian, A; Bucher, B M; Huyse, M L; Himpe, P; Ferrer garcia, R; Sambi, S; Budincevic, I; Neven, M; Bomans, P; Romano, N; Maugeri, E A; Klupp, S C; Dehn, M H; Heinke, R M; Maira vidal, A; Vedia fernandez, M V; Ibanez garcia, P B; Bruyneel, B J E; Materna, T; Al-dahan, N; Alazemi, N; Carroll, R J; Babcock, C; Laird, A M; Eleme, Z; Dhal, A; Valiente dobon, J J; Sahin, E; Goergen, A; Maj, A; Bednarczyk, P A; Borcea, C; Negoita, F; Suliman, G; Marginean, N M; Sotty, C O; Negret, A L; Nae, S A; Nita, C; Golubev, P I; Knyazev, A; Jost, C U; Petrik, K; Strisovska, J; Vaeyrynen, S A; Dracoulis, G D; Rainovski, G I; Uher, J; Fernandez dominguez, B; Chakraborty, P; Avigo, R; Galaviz redondo, D; Castro ribeiro da silva, M; Bernards, C W; Falahat, S; Lekovic, F; Dorrer, H J; Derkx, X; Angus, L J; Sandhu, K S; Gregor, E; Byrne, D J; Haas, H; Lourenco, A A; Sousa pereira, S M; Esteves de araujo, J P; Sousa, J B; De melo mendonca, T M; Tavares de sousa, C; Guerreiro dos santos oliveira custodio, L M; Da rocha rodrigues, P M; Yamaguchi, T; Thompson, P C; Rosenbusch, M; Wienholtz, F; Fischer, P; Iwanicki, J S; Rusek, K M; Hanstorp, D; Severijns, N; Vanpoucke, B R S; Finlay, P E J; Park, S H; Warr, N V; Doornenbal, P C; Imig, A; Seidlitz, M; Moschner, K; Vogt, A; Kaya, L; Martel bravo, I; Orduz, A K; Serot, O; Litvinov, Y; Bommert, M; Hensel, S; Markevich, V; Nishio, K; Ota, S; Matos, I; Zenkevich, A; Picado sandi, E; Forstner, O

    2002-01-01

    The experiments aim at a broad exploration of the properties of atomic nuclei far away from the region of beta stability. Furthermore, the unique radioactive beams of over 60~elements produced at the on-line isotope separators ISOLDE-2 and ISOLDE-3 are used in a wide programme of atomic, solid state and surface physics. Around 300 scientists are involved in the project, coming from about 70 laboratories. \\\\ \\\\ The electromagnetic isotope separators are connected on-line with their production targets in the extracted 600 MeV proton or 910~MeV Helium-3 beam of the Synchro-Cyclotron. Secondary beams of radioactive isotopes are available at the facility in intensities of 10$^1

  8. The duplicated longitudinal epiphysis or ''kissing delta phalanx'': evolution and variation in three different disorders

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, Alison M. [Department of Biochemistry and Medical Genetics, University of Manitoba, 770 Bannatyne Avenue, R3E 0W3, Winnipeg, Manitoba (Canada); Evans, Jane A.; Chudley, Albert E. [Department of Biochemistry and Medical Genetics, University of Manitoba, 770 Bannatyne Avenue, R3E 0W3, Winnipeg, Manitoba (Canada); Department of Pediatrics and Child Health, University of Manitoba and Health Sciences Centre, Winnipeg, Manitoba (Canada); Reed, Martin H. [Department of Biochemistry and Medical Genetics, University of Manitoba, 770 Bannatyne Avenue, R3E 0W3, Winnipeg, Manitoba (Canada); Department of Pediatrics and Child Health, University of Manitoba and Health Sciences Centre, Winnipeg, Manitoba (Canada); Department of Radiology, University of Manitoba and Health Sciences Centre, Winnipeg, Manitoba (Canada)

    2004-06-01

    The delta phalanx, also known as the delta bone, or longitudinal epiphyseal bracket (LEB), has been described in a variety of syndromes and dysplasias. However, the ''kissing delta phalanx'' is not as well recognized in the literature; it consists of a duplicated longitudinal bracketed epiphysis, or a complex of two adjacent delta bones, with opposing convex portions facing each other. Magnetic resonance imaging of the kissing delta phalanx has not been previously described. To describe the evolution, variation and associated osseous anomalies of the kissing delta phalanx in three patients with distinct distal limb malformations using both plain films and magnetic resonance imaging. Patient 1 had Rubinstein-Taybi syndrome and, in addition to a kissing delta phalanx in both feet, had corresponding delta metatarsals (MT1). Patient 2 had Cenani-Lenz syndactyly with distinct variation of the kissing delta phalanx in each hand. He had a disorganized appearance to the phalanges, metacarpal fusions and carpal coalitions. Patient 3 had an isolated oligosyndactyly of the left hand with metacarpal fusions and carpal coalitions. All three patients were followed over time. We describe two types of kissing delta phalanges: separated (without fusion of the corresponding epiphyseal brackets) and nonseparated (with fusion of the corresponding epiphyseal brackets). Both types can be seen in the same patient and are a reflection of the relative degree of segmentation of the two delta bones. (orig.)

  9. Teaching outdoor and adventure activities: describing, analysing and understanding a primary school physical education professional development programme

    OpenAIRE

    Coulter, Maura

    2012-01-01

    Background: Primary schools need well informed and highly motivated teachers to meet the evolving demands of the education system. Professional development is essential to equip primary school teachers to change practice to meet these challenges (Guskey, 2003; Villegas-Reimers, 2003). The purpose of this study was to describe, analyse and understand teachers’ and children’s experiences of a contextualised, whole school professional development programme (PDP) in primary physical education. ...

  10. Fusion technology programme

    International Nuclear Information System (INIS)

    KfK is involved in the European Fusion Programme predominantly in the NET and Fusion Technology part. The following fields of activity are covered: Studies for NET, alternative confinement concepts, and needs and issues of integral testing. Research on structural materials. Development of superconducting magnets. Gyrotron development (part of the Physics Programme). Nuclear technology (breeding materials, blanket design, tritium technology, safety and environmental aspects of fusion, remote maintenance). Reported here are status and results of work under contracts with the CEC within the NET and Technology Programme. The aim of the major part of this R and D work is the support of NET, some areas (e.g. materials, safety and environmental impact, blanket design) have a wider scope and address problems of a demonstration reactor. In the current working period, several new proposals have been elaborated to be implemented into the 85/89 Euratom Fusion Programme. New KfK contributions relate to materials research (dual beam and fast reactor irradiations, ferritic steels), to blanket engineering (MHD-effects) and to safety studies (e.g. magnet safety). (orig./GG)

  11. ADS National Programmes: Italy

    International Nuclear Information System (INIS)

    Following a preliminary design developed in 1998, based on the Energy Amplifier concept proposed by CERN, a first configuration of a lead-bismuth Eutectic cooled Experimental ADS (LBE-XADS) was worked out in the period 1999–2001, under the aegis of MURST, by a group of Italian organizations led by Ansado Nucleare, with the aim of assessing the feasibility of a small sized (80 MWth) ADS. At the end of 1997 a joint effort of ENEA (National Agency for New Technology, Energy and the Environment) and INFN (National Institute for Nuclear Physics) led to the approval of a national programme by MURST (Minister for University and Scientific and Technological Research) named TRASCO (TRAsmutazione SCOrie) aiming at the study of physics and technologies needed to design an ADS for radioactive waste transmutation. The programme consisted of research subprogrammes on accelerator, neutronics, thermalhydraulics analysis, beam window technology, and material technology and compatibility with Pb and Pb-Bi. At now, most of the activities in support to the ADS development carried out at national level are part of EU-funded Projects. These activities are complemented by the programme agreement (AdP -Accordo di programma), signed between ENEA and the Ministry of Economic Development, which provides in general a range of activities aimed at the development of sustainable nuclear fission systems. Several universities and the national industry are involved, besides ENEA, in the activities

  12. A Kiss Lajos-díj 2014. évi nyertese: dr. Slíz Mariann [The 2014 winner of Lajos Kiss Prize: Dr Mariann Slíz

    Directory of Open Access Journals (Sweden)

    Hoffmann, István

    2014-12-01

    Full Text Available The Lajos Kiss Prize, awarded every two or three years since 2006, is considered to be a highly prestigious award for young onomasticians. The 2014 winner of the prize is Dr Mariann Slíz, senior lecturer at the Department of Hungarian Linguistics and Finno-Ugric Studies of Eötvös Loránd University, Budapest. She earned this award for her contribution to Hungarian Onomastics, especially in research on personal names.

  13. Cloning of the Chicken KISS-1 Like Gene and the Expression Analysis of EST Sequence%鸡类KISS-1基因克隆及EST序列表达验证分析

    Institute of Scientific and Technical Information of China (English)

    韩威; 苏一军; 朱云芬; 宋迟; 李国辉; 屠云洁; 张会永; 殷建梅

    2014-01-01

    性成熟启动是一个复杂的生理过程,受“下丘脑-垂体-性腺”轴控制.决定性成熟启动的关键性事件是下丘脑促性腺激素释放激素(GnRH)脉冲式释放增加,KISS-1基因编码产物Kisspeptin通过其受体GPR54能够直接刺激GnRH释放,进而启动性成熟进程,KISS-1/GPR54系统被认为是性成熟启动的关键看门基因.禽类的KISS-1基因在GenBank中尚未被清晰注释.本文以文昌鸡为素材,采用比较基因组学方法分析了不同物种KISS-1及其上、下游基因在染色体上的分布,确定了鸡chr26:1522493-1532710区域为候选片段,通过PCR扩增和克隆测序获得了该候选片段完整序列(命名为类KISS-1序列);同时,采用BLAST程序搜索出9个同源性在50%~85%的EST序列,通过拼接得到3个延伸EST序列.表达验证分析表明,3个延伸EST序列在文昌鸡下丘脑组织cDNA文库中均有表达.

  14. Instrumental neutron activation analysis as an analytical tool supporting the establishment of guidelines and databases for workers' health awareness programmes

    International Nuclear Information System (INIS)

    dangerous diseases that are easily identified. The main problem is that the majority of workers are exposed to low levels of toxic chemicals that can be lethal in the long term, owing to chronic diseases. Most often the onset of the diseases goes unnoticed, and the presence of a lung cancer or heart disease is attributed to non-occupational causes. As a result, these cases of illness do not become part of the compiled data. Besides, there is no specialized and complete literature concerning occupational aetiology, nor is there an evaluation of the onset of disease linked to long term exposure to low levels of toxic agents. With the aim of giving support to the Workers' Health Awareness Programme of the Secretaria Municipal de Saude (Municipal Department of Health) of Belo Horizonte, capital of Minas Gerais state, an assessment was done in galvanizing factories by means of airborne particulate matter collected in air filters and in hair and toenails as biomonitors. This project was approved by the Ethics Committee of the Federal University of Minas Gerais, COEP-UFMG. All research involving human beings has to be submitted to this committee in order to protect the population studied. The k0 instrumental neutron activation analysis (INAA) technique was chosen to be applied for the determination of elements in air filters and in hair and toenail samples, as it can determine several elements in the same sample almost simultaneously, with a low detection limit and without any chemical procedure as is required in the majority of non-nuclear techniques, and also because it requires only a small amount of sample for the analysis. The k0 method was applied to all samples, demonstrating its quality as a versatile technique, and it was confirmed to be one of the most advantageous and suitable nuclear analytical techniques

  15. ADS National Programmes: China

    International Nuclear Information System (INIS)

    In China the conceptual study of an ADS concept which lasted for about five years ended in 1999. As one project of the National Basic Research Programme of China (973 Programme) in energy domain, which is sponsored by the China Ministry of Science and Technology (MOST), a five year programme of fundamental research of ADS physics and related technology was launched in 2000 and passed national review at the end of 2005. From 2007, another five year 973 Programme Key Technology Research of Accelerator Driven Subcritical System for Nuclear waste Transmutation started. The research activities were focused on HPPA physics and technology, reactor physics of external source driven subcritical assembly, nuclear data base and material study. For HPPA, a high current injector consisting of an ECR ion source, LEBT and an RFQ accelerating structure of 3.5 MeV has been built and were being improved. In reactor physics study, a series of neutron multiplication experimental study has been carrying out. The VENUS I facility has been constructed as the basic experimental platform for neutronics study in ADS blanket. VENUS I a zero power subcritical neutron multiplying assembly driven by external neutron produced by a pulsed neutron generator or 252Cf neutron source. The theoretical, experimental and simulation studies on nuclear data, material properties and nuclear fuel circulation related to ADS are carried out in order to provide the database for ADS system analysis. China Institute of Atomic Energy (CIAE), Institute of High Energy Physics (IHEP) and other Chinese institutes carried out the MOST project together. Besides CIAE, China Academy of Science (CAS) pays more and more attention to Advanced Nuclear Fuel Cycles (ANFC). A large programme of ANFC, including ADS and Th based nuclear fuel cycle, has been launched by CAS

  16. An O(n^5) algorithm for MFE prediction of kissing hairpins and 4-chains in nucleic acids

    OpenAIRE

    Chen, Ho-Lin; CONDON, ANNE; Jabbari, Hosna

    2009-01-01

    Efficient methods for prediction of minimum free energy (MFE) nucleic secondary structures are widely used, both to better understand structure and function of biological RNAs and to design novel nano-structures. Here, we present a new algorithm for MFE secondary structure prediction, which significantly expands the class of structures that can be handled in O(n^5) time. Our algorithm can handle H-type pseudoknotted structures, kissing hairpins, and chains of four overlapping stems, as well a...

  17. A Statistical Programme Assignment Model

    DEFF Research Database (Denmark)

    Rosholm, Michael; Staghøj, Jonas; Svarer, Michael

    When treatment effects of active labour market programmes are heterogeneous in an observable way  across the population, the allocation of the unemployed into different programmes becomes a particularly  important issue. In this paper, we present a statistical model designed to improve the present...... duration of unemployment spells may result if a statistical programme assignment model is introduced. We discuss several issues regarding the  plementation of such a system, especially the interplay between the statistical model and  case workers....

  18. Novel FGFR1 and KISS1R Mutations in Chinese Kallmann Syndrome Males with Cleft Lip/Palate

    Science.gov (United States)

    Xu, Hao; Niu, Yonghua; Wang, Tao; Liu, Simin; Xu, Hua; Wang, Shaogang; Liu, Jihong; Ye, Zhangqun

    2015-01-01

    Kallmann syndrome (KS) is characterized by isolated hypogonadotropic hypogonadism (IHH) with anosmia and is sometimes associated with cleft lip/palate (CLP). In order to describe the clinical features, genetic etiology, and treatment outcome of KS males with CLP, we performed genetic screening for 15 known causal IHH genes (KAL1, FGFR1, NELF, FGF8, CHD7, WDR11, SEMA3A, KISS1R, KISS1, PROKR2, PROK2, TAC3, TACR3, GNRH1, and GNRHR) in four KS with CLP patients and six IHH patients without CLP. Two novel heterozygous missense mutations in FGFR1, (NM_001174066): c.776G>A (p.G259E) and (NM_001174066): c.358C>T (p.R120C), were identified in a 23-year-old KS male with cleft lip and an 18-year-old KS patient with cleft lip and palate, dental agenesis, and high arched palate, respectively. These two mutations were not presented in their healthy parents and 200 normal controls. One novel heterozygous missense mutation in KISS1R, (NM_032551): c.587C>A (p.P196H), was identified in an 18-year-old KS male with cleft lip and dental agenesis who developed sperm after being treated with gonadotropin. This mutation was also presented in his healthy father and grandfather. These results have implications for the diagnosis, genetic counseling, and treatment of KS and CLP males with mutations in FGFR1 gene. PMID:26199944

  19. Efficacy of Tailored Physical Activity or Chronic Pain Self-Management Programme on return to work for sick-listed citizens

    DEFF Research Database (Denmark)

    Andersen, Lotte Nygaard; Juul-Kristensen, Birgit; Sørensen, Thomas Lund;

    2015-01-01

    OBJECTIVES: The aim was to evaluate the efficacy of 'Tailored Physical Activity' (TPA) and a 'Chronic Pain Self-management Programme' (CPSMP) compared with a reference group (REF) on return to work after 3 months as sick-listed citizens with pain related to the back or the upper body. METHODS....... In contrast, no benefit of TPA and CPSMP was evident regarding work ability, kinesiophobia or physical capacity after 3 months of follow-up. CONCLUSIONS: The results suggest that TPA is a promising intervention to facilitate return to work and reduce pain among sick-listed citizens with pain related...

  20. What is the IAEA? Programmes and activities that maximize the contribution of nuclear technology to society, while verifying its peaceful use

    International Nuclear Information System (INIS)

    The International Atomic Energy Agency (IAEA) serves as the world's foremost international governmental forum for scientific and technical co-operation in the peaceful use of nuclear technology. Established as an autonomous organization under the United Nations (UN) in 1957, the IAEA represents the culmination of international efforts to make a reality of US President Eisenhower's proposal in his 'Atoms for Peace' speech to the UN General Assembly in 1953. He envisioned the creation of an international body to control and develop the use of atomic energy. Today, the Agency's broad spectrum of services, programmes, and activities is based on the needs of its 130 Member States

  1. Bioergia Research Programme

    International Nuclear Information System (INIS)

    The main objectives of Finland's Bioenergia Research Programme are (1) To develop new methods of producing biofuels which can compete with imported fuels, demonstrating the most promising production methods through pilot schemes, (2) To develop and demonstrate 3 - 4 new pieces of equipment or methods connected with handling and using bioenergy, (3) To produce basic information on conversion techniques and evaluate the quality, usability and environmental impacts of the products as well as the overall economy of the entire production chain and to create 2-3 conversion methods for follow-up development by industry. The principle research areas are (1) Development of production technology for wood-derived fuels, (2) Peat production, (3) The use of bioenergy and (4) Biomass conversion. This conference paper discusses the results obtained so far and reviews in some detail the activities of the programme. 3 figs., 3 tabs

  2. Bioergia Research Programme

    Energy Technology Data Exchange (ETDEWEB)

    Asplund, D.

    1997-12-31

    The main objectives of Finland`s Bioenergia Research Programme are (1) To develop new methods of producing biofuels which can compete with imported fuels, demonstrating the most promising production methods through pilot schemes, (2) To develop and demonstrate 3 - 4 new pieces of equipment or methods connected with handling and using bioenergy, (3) To produce basic information on conversion techniques and evaluate the quality, usability and environmental impacts of the products as well as the overall economy of the entire production chain and to create 2-3 conversion methods for follow-up development by industry. The principle research areas are (1) Development of production technology for wood-derived fuels, (2) Peat production, (3) The use of bioenergy and (4) Biomass conversion. This conference paper discusses the results obtained so far and reviews in some detail the activities of the programme. 3 figs., 3 tabs.

  3. The Kissing-Loop T-Shaped Structure Translational Enhancer of Pea Enation Mosaic Virus Can Bind Simultaneously to Ribosomes and a 5′ Proximal Hairpin

    Science.gov (United States)

    Gao, Feng; Gulay, Suna P.; Kasprzak, Wojciech; Dinman, Jonathan D.

    2013-01-01

    The Pea Enation Mosaic Virus (PEMV) 3′ translational enhancer, known as the kissing-loop T-shaped structure (kl-TSS), binds to 40S subunits, 60S subunits, and 80S ribosomes, whereas the Turnip crinkle virus (TCV) TSS binds only to 60S subunits and 80S ribosomes. Using electrophoretic mobility gel shift assay (EMSA)-based competition assays, the kl-TSS was found to occupy a different site in the ribosome than the P-site-binding TCV TSS, suggesting that these two TSS employ different mechanisms for enhancing translation. The kl-TSS also engages in a stable, long-distance RNA-RNA kissing-loop interaction with a 12-bp 5′-coding-region hairpin that does not alter the structure of the kl-TSS as revealed by molecular dynamics simulations. Addition of the kl-TSS in trans to a luciferase reporter construct containing either wild-type or mutant 5′ and 3′ PEMV sequences suppressed translation, suggesting that the kl-TSS is required in cis to function, and both ribosome-binding and RNA interaction activities of the kl-TSS contributed to translational inhibition. Addition of the kl-TSS was more detrimental for translation than an adjacent eIF4E-binding 3′ translational enhancer known as the PTE, suggesting that the PTE may support the ribosome-binding function of the kl-TSS. Results of in-line RNA structure probing, ribosome filter binding, and high-throughput selective 2′-hydroxyl acylation analyzed by primer extension (hSHAPE) of rRNAs within bound ribosomes suggest that kl-TSS binding to ribosomes and binding to the 5′ hairpin are compatible activities. These results suggest a model whereby posttermination ribosomes/ribosomal subunits bind to the kl-TSS and are delivered to the 5′ end of the genome via the associated RNA-RNA interaction, which enhances the rate of translation reinitiation. PMID:23986599

  4. Metal Abundances of KISS Galaxies. V. Nebular Abundances of Fifteen Intermediate Luminosity Star-Forming Galaxies

    CERN Document Server

    Hirschauer, Alec S; Bresolin, Fabio; Saviane, Ivo; Yegorova, Irina

    2015-01-01

    We present high S/N spectroscopy of 15 emission-line galaxies (ELGs) cataloged in the KPNO International Spectroscopic Survey (KISS), selected for their possession of high equivalent width [O III] lines. The primary goal of this study was to attempt to derive direct-method ($T_e$) abundances for use in constraining the upper-metallicity branch of the $R_{23}$ relation. The spectra cover the full optical region from [O II]{\\lambda}{\\lambda}3726,3729 to [S III]{\\lambda}{\\lambda}9069,9531 and include the measurement of [O III]{\\lambda}4363 in 13 objects. From these spectra, we determine abundance ratios of helium, nitrogen, oxygen, neon, sulfur, and argon. We find these galaxies to predominantly possess oxygen abundances in the range of 8.0 $\\lesssim$ 12+log(O/H) $\\lesssim$ 8.3. We present a comparison of direct-method abundances with empirical SEL techniques, revealing several discrepancies. We also present a comparison of direct-method oxygen abundance calculations using electron temperatures determined from e...

  5. Dorsal spinous process impingement syndrome ('kissing spine') in a cat: imaging appearance and surgical management.

    Science.gov (United States)

    Gutierrez-Quintana, Rodrigo; Lindley, Samantha; Sullivan, Martin; Penderis, Jacques; Wessmann, Annette

    2011-08-01

    Spinal pain is an important clinical presentation in feline patients, but the underlying causes can often be difficult to elucidate. Dorsal spinous process impingement syndrome ('kissing spine' or in human patients 'Baastrup syndrome') is a significant cause of spinal pain in equine and human patients and radiographically is characterised by a close approximation of adjacent spinous processes with reactive bone sclerosis affecting these spinous processes. In this report we describe the first reported case of dorsal spinous process impingement syndrome in a cat causing spinal pain, and successful surgical management of the syndrome. The affected cat presented at 5 years of age for evaluation of a 7-month history of progressive thoracolumbar pain. Radiographs revealed close approximation of the dorsal spinous processes of the seventh, eighth and ninth thoracic vertebrae (T7, T8 and T9), with associated reactive bone sclerosis. Surgical resection of the T8 dorsal spinous process resulted in complete resolution of the clinical signs with no evidence of recurrence 9 months after surgery. PMID:21723173

  6. Perspectives on kiss-and-run: role in exocytosis, endocytosis, and neurotransmission.

    Science.gov (United States)

    Alabi, AbdulRasheed A; Tsien, Richard W

    2013-01-01

    Regulated exocytosis and endocytosis are critical to the function of many intercellular networks, particularly the complex neural circuits underlying mammalian behavior. Kiss-and-run (KR) is an unconventional fusion between secretory vesicles and a target membrane that releases intravesicular content through a transient, nanometer-sized fusion pore. The fusing vesicle retains its gross shape, precluding full integration into the planar membrane, and enough molecular components for rapid retrieval, reacidification, and reuse. KR makes judicious use of finite presynaptic resources, and mounting evidence suggests that it influences synaptic information transfer. Here we detail emerging perspectives on KR and its role in neurotransmission. We additionally formulate a restraining force hypothesis as a plausible mechanistic basis for KR and its physiological modulation in small nerve terminals. Clarification of the mechanism and function of KR has bearing on understanding the kinetic transitions underlying SNARE-mediated fusion, interactions between vesicles and their local environment, and the influence of release dynamics on neural information processing. PMID:23245563

  7. Programmable hardware for reconfigurable computing systems

    Science.gov (United States)

    Smith, Stephen

    1996-10-01

    In 1945 the work of J. von Neumann and H. Goldstein created the principal architecture for electronic computation that has now lasted fifty years. Nevertheless alternative architectures have been created that have computational capability, for special tasks, far beyond that feasible with von Neumann machines. The emergence of high capacity programmable logic devices has made the realization of these architectures practical. The original ENIAC and EDVAC machines were conceived to solve special mathematical problems that were far from today's concept of 'killer applications.' In a similar vein programmable hardware computation is being used today to solve unique mathematical problems. Our programmable hardware activity is focused on the research and development of novel computational systems based upon the reconfigurability of our programmable logic devices. We explore our programmable logic architectures and their implications for programmable hardware. One programmable hardware board implementation is detailed.

  8. A Comparison of the Detectability of Dry Contact Kissing Bonds in Adhesive Joints Using Longitudinal, Shear and High Power Ultrasonic Techniques

    Science.gov (United States)

    Brotherhood, C. J.; Drinkwater, B. W.; Guild, F. J.

    2003-03-01

    This paper details a study on the detectability of dry contact kissing bonds in adhesive joints using three ultrasonic inspection techniques. Conventional normal incidence longitudinal and shear wave inspection were conducted on dry contact kissing bonds using a standard immersion transducer and an EMAT respectively. The detectability of the dry contact kissing bonds was assessed by calculating the reflection coefficient of the interface at varying loads for a number of surface roughnesses. A high power ultrasonic method was also employed to determine the non-linear behavior of the adhesive interface. The non-linearity of the interface was determined by the ratio of the amplitudes of the first harmonic and fundamental frequencies of the transmitted waveform. It was found that the high power technique showed the greatest sensitivity to kissing bonds at low contact pressures, however at high loads conventional longitudinal wave testing was more sensitive. It was also noted that a combination of two or more techniques could provide enhanced information about the kissing bond compared to a single technique alone.

  9. The (cost-effectiveness of an individually tailored long-term worksite health promotion programme on physical activity and nutrition: design of a pragmatic cluster randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Burdorf Alex

    2007-09-01

    Full Text Available Abstract Background Cardiovascular disease is the leading cause of disability and mortality in most Western countries. The prevalence of several risk factors, most notably low physical activity and poor nutrition, is very high. Therefore, lifestyle behaviour changes are of great importance. The worksite offers an efficient structure to reach large groups and to make use of a natural social network. This study investigates a worksite health promotion programme with individually tailored advice in physical activity and nutrition and individual counselling to increase compliance with lifestyle recommendations and sustainability of a healthy lifestyle. Methods/Design The study is a pragmatic cluster randomised controlled trial with the worksite as the unit of randomisation. All workers will receive a standard worksite health promotion program. Additionally, the intervention group will receive access to an individual Health Portal consisting of four critical features: a computer-tailored advice, a monitoring function, a personal coach, and opportunities to contact professionals at request. Participants are employees working for companies in the Netherlands, being literate enough to read and understand simple Internet-based messages in the Dutch language. A questionnaire to assess primary outcomes (compliance with national recommendations on physical activity and on fruit and vegetable intake will take place at baseline and after 12 and 24 months. This questionnaire also assesses secondary outcomes including fat intake, self-efficacy and self-perceived barriers on physical activity and fruit and vegetable intake. Other secondary outcomes, including a cardiovascular risk profile and physical fitness, will be measured at baseline and after 24 months. Apart from the effect evaluation, a process evaluation will be carried out to gain insight into participation and adherence to the worksite health promotion programme. A cost-effectiveness analysis and

  10. Developing the necessary infrastructure. Chapter 1; IAEA activities in support of countries considering embarking on Nuclear Power Programme

    International Nuclear Information System (INIS)

    The IAEA supports in a variety of ways in establishing an appropriate infra-structure necessary to secure safe and reliable operation and still maintaining the international safeguards regime, especially in developing countries which are considering introduction of nuclear power programme. The TC projects to support introduction of nuclear power has been formulated and its number increased significantly recently. Various guidance documents have been published by the IAEA recently to enable progressive development of national infrastructure. The IAEA guidance documents constitute a basis of advises to newcomer countries. The recently formulated important mission is INIR mission to review the status of national infrastructure in the context of measuring the distance to the expected milestone. Finally, it is expected that the newcomers would make informed decision-making on going to nuclear power by fully understanding the necessary obligations and national long-term commitment, by confirming viability of nuclear power options in the country's energy plan through Energy Planning and long-term strategic assessment using IAEA guidance and tools

  11. An novel analog programmable power supply for active gain control of the Multi-Pixel Photon Counter (MPPC)

    CERN Document Server

    Li, Zhengwei; Xu, Yupeng; Yan, Bo; Li, Yanguo; Lu, Xuefeng; Li, Xufang; Zhang, Shuo; Chang, Zhi; Li, Jicheng; Zhang, Yifei; Zhao, Jianling

    2016-01-01

    Silicon Photo-Multipliers (SiPM) are regarded as novel photo-detector to replace conventional Photo-Multiplier Tubes (PMTs). However, the breakdown voltage dependence on the ambient temperature results in a gain variation of $\\sim$3$\\% /^{\\circ} \\mathrm C$. This can severely limit the application of this device in experiments with wide range of operating temperature, especially in space telescope. An experimental setup in dark condition was established to investigate the temperature and bias voltage dependence of gain for the Multi-Pixel Photon Counter (MPPC), one type of the SiPM developed by Hamamatsu. The gain and breakdown voltage dependence on operating temperature of an MPPC can be approximated by a linear function, which is similar to the behavior of a zener diode. The measured temperature coefficient of the breakdown voltage is $(59.4 \\pm 0.4$ mV)$/^{\\circ} \\mathrm C$. According to this fact, a programmable power supply based on two zener diodes and an operational amplifier was designed with a positiv...

  12. Review of reactor physics activities relevant to FBR and ATR programmes in PNC, Japan, June 1977 to October 1978

    International Nuclear Information System (INIS)

    Reactor physics works in Power Reactor and Nuclear Fuel Development Corporation (PNC) are carried out in support of the FBR and ATR development programmes. The works are in progress with high efficiency, in cooperation of other related organizations in Japan and also overseas. The experimental fast reactor ''Joyo'' reached its full power of 50 MWt, being operated now to obtain technical data and experiences. The prototype fast breeder reactor ''Monju'' is nearing completion of its final design, and the surveys on its proposed site have been finished. The advanced thermal reactor ''Fugen'', a heavy water-moderated and boiling light water-cooled, reactor reached the criticality, and the power generation was successfully achieved. The data to be obtained are used for the development of a large demonstration reactor. After describing on these types of reactors briefly, the works on reactor physics are described as follows: for fast reactors, mockup experiment and analysis, evaluation of actinide nuclear data, development of core analytical method, and research on shielding; and for ATR, research with a deuterium critical assembly. (Mori, K.)

  13. Design of the iPlay study: Systematic development of a physical activity injury prevention programme for primary school children

    NARCIS (Netherlands)

    Collard, D.C.M.; Chinapaw, M.J.M.; Mechelen, W.V.; Verhagen, E.A.L.M.

    2009-01-01

    Health benefits of physical activity in children are well known. However, a drawback is the risk of physical activity-related injuries. Children are at particular risk for these injuries, because of a high level of exposure. Because of the high prevalence of physical activity injuries and the negati

  14. Proficiency tests in the determination of activity of radionuclides in radiopharmaceutical products measured by nuclear medicine services in 8 years of comparison programmes in Brazil.

    Science.gov (United States)

    Tauhata, Luiz; Iwahara, Akira; de Oliveira, Antonio E; Rezende, Eduarda Alexandre; Delgado, José Ubiratan; da Silva, Carlos José; Dos Santos, Joyra A; Nícoli, Ieda G; Alabarse, Frederico G; Xavier, Ana Maria

    2008-01-01

    Proficiency tests were applied to assess the performance of 74 nuclear medicine services in activity measurements of (131)I, (123)I, (99)Tc(m), (67)Ga and (201)Tl. These tests produced 913 data sets from comparison programmes promoted by the National Laboratory for Ionizing Radiation Metrology (LNMRI) from 1999 to 2006. The data were evaluated against acceptance criteria for accuracy and precision and assigned as Acceptable or Not acceptable accordingly. In addition, three other statistical parameters were used as complementary information for performance evaluation which related to normative requirements and to radionuclide calibrators. The results have shown a necessity to improve quality control procedures and unsatisfactory performances of radionuclide calibrators, which incorporate Geiger-Müller detectors. PMID:18346902

  15. Proficiency tests in the determination of activity of radionuclides in radiopharmaceutical products measured by nuclear medicine services in 8 years of comparison programmes in Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Tauhata, Luiz [Laboratorio Nacional de Metrologia das Radiacoes Ionizantes, Instituto de Radioprotecao e Dosimetria, Comissao Nacional de Energia Nuclear, Rio de Janeiro (Brazil)], E-mail: tauhata@ird.gov.br; Iwahara, Akira; Oliveira, Antonio E. de [Laboratorio Nacional de Metrologia das Radiacoes Ionizantes, Instituto de Radioprotecao e Dosimetria, Comissao Nacional de Energia Nuclear, Rio de Janeiro (Brazil); Rezende, Eduarda Alexandre [Centro Federal de Educacao Tecnologica de Quimica de Nilopolis, Nilopolis (Brazil); Ubiratan Delgado, Jose; Silva, Carlos Jose da [Laboratorio Nacional de Metrologia das Radiacoes Ionizantes, Instituto de Radioprotecao e Dosimetria, Comissao Nacional de Energia Nuclear, Rio de Janeiro (Brazil); Santos, Joyra A. dos [CORAD, Comissao Nacional de Energia Nuclear, Rio de Janeiro (Brazil); Nicoli, Ieda G. [DIPLAN, Comissao Nacional de Energia Nuclear, Brasilia (Brazil); Alabarse, Frederico G.; Xavier, Ana Maria [ESPOA, Comissao Nacional de Energia Nuclear, Porto Alegre (Brazil)

    2008-06-15

    Proficiency tests were applied to assess the performance of 74 nuclear medicine services in activity measurements of {sup 131}I, {sup 123}I, {sup 99}Tc{sup m}, {sup 67}Ga and {sup 201}Tl. These tests produced 913 data sets from comparison programmes promoted by the National Laboratory for Ionizing Radiation Metrology (LNMRI) from 1999 to 2006. The data were evaluated against acceptance criteria for accuracy and precision and assigned as Acceptable or Not acceptable accordingly. In addition, three other statistical parameters were used as complementary information for performance evaluation which related to normative requirements and to radionuclide calibrators. The results have shown a necessity to improve quality control procedures and unsatisfactory performances of radionuclide calibrators, which incorporate Geiger-Mueller detectors.

  16. An O(n(5)) algorithm for MFE prediction of kissing hairpins and 4-chains in nucleic acids.

    Science.gov (United States)

    Chen, Ho-Lin; Condon, Anne; Jabbari, Hosna

    2009-06-01

    Efficient methods for prediction of minimum free energy (MFE) nucleic secondary structures are widely used, both to better understand structure and function of biological RNAs and to design novel nano-structures. Here, we present a new algorithm for MFE secondary structure prediction, which significantly expands the class of structures that can be handled in O(n(5)) time. Our algorithm can handle H-type pseudoknotted structures, kissing hairpins, and chains of four overlapping stems, as well as nested substructures of these types.

  17. NUMERICAL SIMULATION OF MOLTEN POOL AND CONTROL STRATEGY OF KISS POINT IN A TWIN-ROLL STRIP CASTING PROCESS

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Coupled turbulent flow, temperature fields of the twin-roll casting strip process were simulated by three-dimensional finite element method. Based on the heat balance calculation and using inverse methods between the simulations and real experiments,the relational models among casting speed, location, and coefficient of heat transfer between molten metal and rolls in different regions are given. In the simulation, the calculated surface temperatures are in good agreement with the measured values. An on-line model of kiss point is derived by simulations and the geometry of molten pool,corresponding control strategy is also proposed.

  18. PPARdelta agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle.

    Science.gov (United States)

    Constantin, Despina; Constantin-Teodosiu, Dumitru; Layfield, Robert; Tsintzas, Kostas; Bennett, Andrew J; Greenhaff, Paul L

    2007-08-15

    PPARalpha agonism impairs mitochondrial function, but the effect of PPARdelta agonism on mitochondrial function is equivocal. Furthermore, PPARalpha and delta agonism increases muscle fatty acid oxidation, potentially via activation of FOXO1 signalling and PDK4 transcription. Since FOXO1 activation has also been suggested to increase transcription of MAFbx and MuRF-1, and thereby the activation of ubiquitin-proteasome mediated muscle proteolysis, this raises the possibility that muscle fuel selection and the induction of a muscle atrophy programme could be regulated by a single common signalling pathway. We therefore investigated the effect of PPARdelta (delta) agonist, GW610742, administration on muscle mitochondrial function, fuel regulation, and atrophy and growth related signalling pathways in vivo. Twenty-four male Wistar rats received vehicle or GW610742 (5 and 100 mg per kg body mass (bm)) orally for 6 days. Soleus muscle was used to determine maximal rates of ATP production (MRATP) in isolated mitochondria, gene and protein expression, and enzyme activities. MRATP were unchanged by GW610742. Muscle PDK2 and PDK4 mRNA expression increased with GW610742 (100 mg (kg bm)(-1)) compared to vehicle (P<0.05), and was paralleled by a twofold increase in PDK4 protein expression (P<0.05). The activity of beta-hydroxyacyl-CoA dehydrogenase increased with GW610742 (P<0.05). Muscle MuRF1 and MAFbx mRNA expression was increased by GW610742 (100 mg (kg bm)(-1)) compared to vehicle (P<0.05), and was matched by increased protein expression (P<0.001), whilst Akt1 protein declined (P<0.05). There was no effect of GW610742 on 20S proteasome activity and mRNA expression, or the muscle DNA: protein ratio. GW610742 switched muscle fuel metabolism towards decreased carbohydrate use and enhanced lipid utilization, but did not induce mitochondrial dysfunction. Furthermore, GW610742 initiated a muscle atrophy programme, possibly via changes in the Akt1/FOXO/MAFbx and MuRF1 signalling

  19. Self-reported care activities in a home-based intervention programme for families with multiple problems

    NARCIS (Netherlands)

    Tausendfreund, Tim; Metselaar, Janneke; Conradie, Jelte; de Groot, Maria Helena; Schipaanboord, Nicolien; Knot-Dickscheit, Jana; Grietens, Hans; Knorth, Erik J.

    2015-01-01

    The purpose of this paper is to describe the development and application of the KIPP-list of care activities. The acronym KIPP stands for Knowledge and Insight into Primary Processes. The instrument is intended as a tool for family coaches to systematically report care activities conducted in the Du

  20. Evaluation of a school-based intervention programme to promote physical activity: an application of the theory of planned behavior.

    Science.gov (United States)

    Tsorbatzoudis, Haralambos

    2005-12-01

    The Theory of Planned Behavior provides a useful framework to study attitudes toward participation in physical activity. The objective of the study was to test the effectiveness of an intervention in manipulating the variables of the Theory of Planned Behavior and exercise habits with 366 high school students (M = 14.2 yr., SD = .7; 201 boys and 165 girls). The students were divided into intervention and control groups. A questionnaire to measure components of the theory, and the Baecke Questionnaire of Habitual Activity measuring exercise habits, were administered. The intervention lasted 12 wk. and included posters and lectures promoting participation in physical activity. Analyses showed the intervention was effective in improving attitudes towards physical activity, perceived behavioral control, intention, and self-reported actual behavior, but it was ineffective for improving attitude strength, subjective norms, and role identity. The results provide useful information for physical education teachers interested in promoting students' positive attitudes towards physical activity. PMID:16491680

  1. Olympic Partner Programme

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ The Olympic Partner Programme (TOP) is an international Olympic marketing programme created by the International Olympic Committee (IOC),which includes the Organising Committees of the Games,the National Olympic Committees and the TOP Partners.

  2. Why some do but most don't. Barriers and enablers to engaging low-income groups in physical activity programmes: a mixed methods study

    Directory of Open Access Journals (Sweden)

    Fox Kenneth R

    2011-06-01

    Full Text Available Abstract Background The beneficial effect of physical activity for the prevention of a range of chronic diseases is widely acknowledged. These chronic conditions are most pronounced in economically disadvantaged groups where physical activity levels are consistently lower, yet this group is particularly difficult to recruit and retain in physical activity programmes. This study examined the perceptions of participants, non-participants, and exercise leaders in a low-income area regarding barriers, motives, and enabling factors for organised physical activity with a view to improving recruitment and retention. Methods A mixed methods research approach was adopted to guide data collection and analysis. A survey, incorporating the Motivation for Physical Activity Measure - Revised (MPAM-R, was used to assess the motivations of 152 physical activity session participants in a highly deprived suburban neighbourhood. The MPAM-R data were analysed using t tests, analyses of variance to estimate age, body mass index, and activity mode differences and Pearson's correlation coefficient to address associations. Semi-structured interviews were also conducted with 33 local residents who did not participate in activity sessions and with 14 activity session leaders. All interviews were audio-taped, transcribed verbatim and analyzed using an inductive thematic approach. Results Participants reported cost, childcare, lack of time and low awareness as barriers to joining activity classes. The need for support, confidence and competence in order to take up activity was widely expressed, particularly among women. Once people are active, high levels of social interaction, interest and enjoyment are associated with improved levels of retention, with different types of physical activity scoring differently on these factors. Conclusions This study suggests that some factors such as cost, the fear of 'walking in alone', accessibility of facilities, and appropriate

  3. KiSS-1基因在黄牛精子发生中的表达%Expression of KiSS-1 gene in bovine testis spermatogenesis

    Institute of Scientific and Technical Information of China (English)

    邵宝平; 王继卿; 罗玉柱; 王建林; 陈建龙; 柴尔青; 徐元青

    2011-01-01

    为探讨亲吻素在黄牛精子发生中的生理功能,并为家畜生殖生理学研究提供参考,运用免疫组织化学SABC染色法并采用Image Pro-Plus 6.0软件,对成年黄牛睾丸中KiSS-1的表达及分布特征进行了研究。结果显示,在成年黄牛睾丸的精原细胞、初级精母细胞、次级精母细胞、早期精子细胞及间质细胞中均发现KiSS-1阳性反应产物,其各阳性细胞积分光密度(IOD)值的大小顺序为IOD初级精母细胞〉IOD间质细胞〉IOD次级精母细胞〉IOD精原细胞〉IOD早期精子细胞,而阳性产物在晚期精子细胞、精子和支持细胞及睾丸间质血管上未被发现;在部分间质细胞周围可见大量的KiSS-1免疫阳性反应产物,而在其他阳性细胞周围未见此现象。结果证实,KiSS-1基因在黄牛精子发生中发挥着重要作用,尤其在精原细胞的有丝分裂和精母细胞的减数分裂中可能发挥着非常重要的作用,而且间质细胞具有向睾丸微环境中分泌KiSS-1的功能。%To explore the physiologic function of the kisspeptins in bovine spermatogenesis as well as provide reference to research reproductive physiology of livestock,kisspeptins-1(Kiss-1) expression characteristics in the testis of adult cattle were studied by using SABC immunohistochemical staining and image analysis software(Image Pro-Plus6.0).In result,the KiSS-1 immunopositive production were found in the spermatogonia,primary spermatocytes,secondary spermatocytes,early spermatids and interstitial cells of the adult bovine testes,with the order of the total optical density of the positive cells(IOD) value as IODprimary spermatocytes IODinterstitial cells IODsecondary spermatocytes〉IODspermatogonia 〉IODearly spermatids(P〈0.05).However,the production were not found in the late spermatids,sperm,sertoli cells and interstitial blood vessels of the adult cattle testes.The large KiSS-1 immunoreactivity production was seen around

  4. Positive affect as coercive strategy: conditionality, activation and the role of psychology in UK government workfare programmes

    OpenAIRE

    Friedli, Lynne; Stearn, Robert

    2015-01-01

    Eligibility for social security benefits in many advanced economies is dependent on unemployed and underemployed people carrying out an expanding range of job search, training and work preparation activities, as well as mandatory unpaid labour (workfare). Increasingly, these activities include interventions intended to modify attitudes, beliefs and personality, notably through the imposition of positive affect. Labour on the self in order to achieve characteristics said to increase employabil...

  5. UNESCO's Ethics Education Programme.

    NARCIS (Netherlands)

    Have, H.A.M.J. ten

    2008-01-01

    Unesco initiated the Ethics Education Programme in 2004 at the request of member states to reinforce and increase the capacities in the area of ethics teaching. The programme is focused on providing detailed information about existing teaching programmes. It also develops and promotes teaching throu

  6. Gfi1, a transcriptional repressor, inhibits the induction of the T helper type 1 programme in activated CD4 T cells.

    Science.gov (United States)

    Suzuki, Junpei; Maruyama, Saho; Tamauchi, Hidekazu; Kuwahara, Makoto; Horiuchi, Mika; Mizuki, Masumi; Ochi, Mizuki; Sawasaki, Tatsuya; Zhu, Jinfang; Yasukawa, Masaki; Yamashita, Masakatsu

    2016-04-01

    A transcriptional repressor Gfi1 promotes T helper type 2 (Th2) cell development and inhibits Th17 and inducible regulatory T-cell differentiation. However, the role of Gfi1 in regulating Th1 cell differentiation and the Th1-type immune response remains to be investigated. We herein demonstrate that Gfi1 inhibits the induction of the Th1 programme in activated CD4 T cells. The activated Gfi1-deficient CD4 T cells spontaneously develop into Th1 cells in an interleukin-12- and interferon-γ-independent manner. The increase of Th1-type immune responses was confirmed in vivo in Gfi1-deficient mice using a murine model of nickel allergy and delayed-type hypersensitivity (DTH). The expression levels of Th1-related transcription factors were found to increase in Gfi1-deficient activated CD4 T cells. Tbx21, Eomes and Runx2 were identified as possible direct targets of Gfi1. Gfi1 binds to the Tbx21, Eomes and Runx2 gene loci and reduces the histone H3K4 methylation levels in part by modulating Lsd1 recruitment. Together, these findings demonstrate a novel regulatory role of Gfi1 in the regulation of the Th1-type immune response. PMID:26749286

  7. MDEP Conference on New Reactor Design Activities - Multinational Design Evaluation Programme (MDEP) Conference Proceedings, Paris, France, 10-11 September 2009

    International Nuclear Information System (INIS)

    The MDEP is a unique ten-nation initiative being undertaken by national regulatory authorities from Canada, China, Finland, France, Japan, Republic of Korea, the Russian Federation, South Africa, the United Kingdom, and the United States with the purposes of co-operating on safety design reviews of new reactors and identifying opportunities to harmonise and converge on safety licensing review practices and requirements. The OECD Nuclear Energy Agency has been chosen to provide the technical secretariat support. The International Atomic Energy Agency participates in many of the MDEP activities. Started in 2007 with co-operation on various pilot project issues, the MDEP's expected outcomes are: (1) improved effectiveness and efficiency of regulatory safety design reviews, (2) increased quality of safety assessments, and (3) and identified areas for the convergence of regulatory requirements and practices. Making each regulator stronger in its ability to make sovereign safety decisions is a key objective that cuts across all MDEP activities. In 2008, the top regulators from each national authority met as the MDEP Policy Group and adopted the present structure and programme of work for the MDEP, including the pursuit of co-operation on specific safety design reviews and pursuing closer co-ordination on harmonisation and convergence issues such as digital instrumentation and control, mechanical codes and standards, and vendor inspections. The MDEP is currently a long-term programme that focuses in near term and interim results to share within MDEP and with other stakeholders. With effective communications in mind, the MDEP Policy Group directed the NEA to co-ordinate the Conference on New Reactor Design Activities with the purpose of communicating to a wide spectrum of stakeholders worldwide as to the program of work and accomplishments of the MDEP, and soliciting feedback and input from these stakeholders regarding recommendations on how to co-operate more efficiently

  8. A reappraisal of the virtues of private sector employment programmes

    DEFF Research Database (Denmark)

    Graversen, Brian Krogh; Jensen, Peter

    2010-01-01

    This paper evaluates the employment effects of active labour market programmes for Danish welfare benefit recipients, focusing on private sector employment (PSE) programmes. Using a latent variable model that allows for heterogeneous treatment effects among observationally identical persons, we...

  9. ADS National Programmes: Belgium

    International Nuclear Information System (INIS)

    The Belgian activities in the field of Accelerator Driven Systems (ADS) are mainly related to the MYRRHA project development. MYRRHA is an accelerator driven, multi purpose fast neutron spectrum facility for R&D, cooled by a lead-bismuth eutectic. SCK•CEN has started the MYRRHA project as a national programme with several national & international bilateral collaboration agreements; the project has now evolved as an European integrated project in the frame of the IPEUROTRANS (European Commission, Sixth Framework Programme). The MYRRHA ‘Draft-2’ predesign file (completed in the early 2005) has been proposed to the partners as a basis for the XT-ADS machine. After a detailed investigation of potential alternatives, the MYRRHA concept (for the subcritical core, the primary coolant system, the accommodation of experimental rigs, the reactor vessel and the spallation target) has been kept with some modifications to achieve the XT-ADS objectives. The most recent version of the XT-ADS design was presented in the 2007 TWG meeting

  10. Methods of Calculating Unit Activity and Output Costs in French Universities. Technical Report. Programme on Institutional Management in Higher Education.

    Science.gov (United States)

    Babeau, Andre; And Others

    Proposals for calculating unit costs are advocated that are based on a body of methods common to the member universities. Production inputs and cost components in French universities are studied in terms of resources at the disposal of the university, and staffing, capital, operating, and transfer costs. Identification of activities and…

  11. Implementation of a metrology programme to provide traceability for radionuclides activity measurements in the CNEN Radiopharmaceuticals Producers Centers

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, Erica A.L. de; Braghirolli, Ana M.S.; Tauhata, Luiz; Gomes, Regio S.; Silva, Carlos J., E-mail: erica@ien.gov.br [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Delgado, Jose U.; Oliveira, Antonio E.; Iwahara, Akira, E-mail: ealima@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2013-07-01

    The commercialization and use of radiopharmaceuticals in Brazil are regulated by Agencia Nacional de Vigilancia Sanitaria (ANVISA) which require Good Manufacturing Practices (GMP) certification for Radiopharmaceuticals Producer Centers. Quality Assurance Program should implement the GMP standards to ensure radiopharmaceuticals have requirements quality to proving its efficiency. Several aspects should be controlled within the Quality Assurance Programs, and one of them is the traceability of the Radionuclides Activity Measurement in radiopharmaceuticals doses. The quality assurance of activity measurements is fundamental to maintain both the efficiency of the nuclear medicine procedures and patient and exposed occupationally individuals safety. The radiation doses received by patients, during the nuclear medicine procedures, is estimated according to administered radiopharmaceuticals quantity. Therefore it is very important either the activity measurements performed in radiopharmaceuticals producer centers (RPC) as the measurements performed in nuclear medicine services are traceable to national standards. This paper aims to present an implementation program to provide traceability to radionuclides activity measurements performed in the dose calibrators(well type ionization chambers) used in Radiopharmaceuticals Producer Center placed in different states in Brazil. The proposed program is based on the principles of GM Pand ISO 17025 standards. According to dose calibrator performance, the RPC will be able to provide consistent, safe and effective radioactivity measurement to the nuclear medicine services. (author)

  12. Active Agents of Health Promotion? The School's Role in Supporting the HPV Vaccination Programme

    Science.gov (United States)

    Spratt, Jennifer; Shucksmith, Janet; Philip, Kate; McNaughton, Rebekah

    2013-01-01

    By providing a place in which children can be accessed, the school has long been a site for population-level health initiatives. Recent policy shifts towards health-promoting schools have however re-cast the school from passive host to active collaborator in public health. This paper examines secondary school teachers' views of their roles as…

  13. Implementation of a metrology programme to provide traceability for radionuclides activity measurements in the CNEN Radiopharmaceuticals Producers Centers

    International Nuclear Information System (INIS)

    The commercialization and use of radiopharmaceuticals in Brazil are regulated by Agencia Nacional de Vigilancia Sanitaria (ANVISA) which require Good Manufacturing Practices (GMP) certification for Radiopharmaceuticals Producer Centers. Quality Assurance Program should implement the GMP standards to ensure radiopharmaceuticals have requirements quality to proving its efficiency. Several aspects should be controlled within the Quality Assurance Programs, and one of them is the traceability of the Radionuclides Activity Measurement in radiopharmaceuticals doses. The quality assurance of activity measurements is fundamental to maintain both the efficiency of the nuclear medicine procedures and patient and exposed occupationally individuals safety. The radiation doses received by patients, during the nuclear medicine procedures, is estimated according to administered radiopharmaceuticals quantity. Therefore it is very important either the activity measurements performed in radiopharmaceuticals producer centers (RPC) as the measurements performed in nuclear medicine services are traceable to national standards. This paper aims to present an implementation program to provide traceability to radionuclides activity measurements performed in the dose calibrators(well type ionization chambers) used in Radiopharmaceuticals Producer Center placed in different states in Brazil. The proposed program is based on the principles of GM Pand ISO 17025 standards. According to dose calibrator performance, the RPC will be able to provide consistent, safe and effective radioactivity measurement to the nuclear medicine services. (author)

  14. Expert validation of fit-for-purpose guidelines for designing programmes of assessment.

    NARCIS (Netherlands)

    Dijkstra, J.; Galbraith, R.; Hodges, B.D.; McAvoy, P.A.; McCrorie, P.; Southgate, L.J.; Vleuten, C.P.M. van der; Wass, V.; Schuwirth, L.W.

    2012-01-01

    ABSTRACT: BACKGROUND: An assessment programme, a purposeful mix of assessment activities, is necessary to achieve a complete picture of assessee competence. High quality assessment programmes exist, however, design requirements for such programmes are still unclear. We developed guidelines for desig

  15. Physical Activity and Quality of Life in Severely Obese Adults during a Two-Year Lifestyle Intervention Programme

    Directory of Open Access Journals (Sweden)

    Randi Jepsen

    2015-01-01

    Full Text Available It is unknown how changes in physical activity may affect changes in quality of life (QoL outcomes during lifestyle interventions for severely obese adults. The purpose of this study was to examine associations in the patterns of change between objectively assessed physical activity as the independent variable and physical, mental, and obesity-specific QoL and life satisfaction as the dependent variables during a two-year lifestyle intervention. Forty-nine severely obese adults (37 women; 43.6±9.4 years; body mass index 42.1±6.0 kg/m2 participated in the study. Assessments were conducted four times using Medical Outcomes Study Short-Form 36 Health Survey (SF-36, Obesity-Related Problems (OP scale, a single item on life satisfaction, and accelerometers. The physical component summary (PCS score and the mental component summary (MCS score were used as SF-36 outcomes. Associations were determined using linear regression analyses and reported as standardized coefficients (stand. coeff.. Change in physical activity was independently associated with change in PCS (stand. coeff. = 0.35, P=.033, MCS (stand. coeff. = 0.51, P=.001, OP (stand. coeff. = −0.31,  P=.018, and life satisfaction (stand. coeff. = 0.39, P=.004 after adjustment for gender, age, and change in body mass index.

  16. Las malqueridas: La chambre verte de F. Truffaut, Mes petites amoureuses de J. Eustache, Kiss me deadly de R. Aldrich y además Free Rider

    OpenAIRE

    La madriguera

    2001-01-01

    La madriguera (2001). Las malqueridas: La chambre verte de F. Truffaut, Mes petites amoureuses de J. Eustache, Kiss me deadly de R. Aldrich y además Free Rider. Ediciones de intervención cultural S.L. http://hdl.handle.net/10251/41938. 58 58 36

  17. The HADES RV Programme with HARPS-N@TNG. III. Flux-flux and activity-rotation relationships of early-M dwarfs

    CERN Document Server

    Maldonado, J; Stelzer, B; Biazzo, K; Lanza, A F; Maggio, A; Micela, G; González-Álvarez, E; Affer, L; Claudi, R U; Cosentino, R; Damasso, M; Desidera, S; Hernández, J I González; Gratton, R; Leto, G; Messina, S; Molinari, E; Pagano, I; Perger, M; Piotto, G; Rebolo, R; Ribas, I; Sozzetti, A; Mascareño, A Suárez; Sanchez, R Zanmar

    2016-01-01

    (Abridged) Understanding stellar activity in M dwarfs is crucial for the physics of stellar atmospheres as well as for ongoing radial velocity exoplanet programmes. Despite the increasing interest in M dwarfs, our knowledge of the chromospheres of these stars is far from being complete. We aim to test whether the relations between activity, rotation, and stellar parameters and flux-flux relationships also hold for early-M dwarfs on the main-sequence. We analyse in an homogeneous and coherent way a well defined sample of 71 late-K/early-M dwarfs that are currently being observed in the framework of the HArps-n red Dwarf Exoplanet Survey (HADES). Rotational velocities are derived using the cross-correlation technique while emission flux excesses in the Ca II H & K and Balmer lines from Halpha up to Hepsilon are obtained by using the spectral subtraction technique. The relationships between the emission excesses and the stellar parameters are studied. Relations between pairs of fluxes of different chromosphe...

  18. Identification of a novel kisspeptin with high gonadotrophin stimulatory activity in the dog

    NARCIS (Netherlands)

    Albers-Wolthers, Karin H J; de Gier, Jeffrey; Kooistra, Hans S; Rutten, Victor P M G; van Kooten, Peter J S; de Graaf, Janneke J; Leegwater, Peter A J; Millar, Robert P; Schaefers-Okkens, Auke C

    2014-01-01

    Kisspeptin (KISS1) and its receptor (KISS1r) are essential for normal reproductive function in many species, but the role of kiss1/kiss1r signalling in the dog has not yet been elucidated. The aims of this study were to identify the canine kiss1 and kiss1r genes and to determine gonadotrophin and oe

  19. Education, Training and the Euratom Framework Programme

    International Nuclear Information System (INIS)

    The maintaining of knowledge implies education and training programmes that ensure not only the instruction of students and trainees but also the transfer of knowledge across generations. This is especially important for research in the Euratom field in the present context of nuclear renaissance. DG-Research is responsible for the implementation of the Euratom Framework Programme on nuclear research and training. Through these activities, it is striving to promote the integration of national radiation protection research programmes in Europe, including education and training in radiation protection. These education and training activities supported in the Euratom Programme are helping to establish top-quality teaching modules assembled into masters programmes or higher-level training packages jointly qualified and mutually recognised across the EU. This Euratom approach is entirely in line with the Bologna process. This paper presents and discusses the various actions in education and training in radiation protection supported by DG- Research. (authors)

  20. Positive affect as coercive strategy: conditionality, activation and the role of psychology in UK government workfare programmes.

    Science.gov (United States)

    Friedli, Lynne; Stearn, Robert

    2015-06-01

    Eligibility for social security benefits in many advanced economies is dependent on unemployed and underemployed people carrying out an expanding range of job search, training and work preparation activities, as well as mandatory unpaid labour (workfare). Increasingly, these activities include interventions intended to modify attitudes, beliefs and personality, notably through the imposition of positive affect. Labour on the self in order to achieve characteristics said to increase employability is now widely promoted. This work and the discourse on it are central to the experience of many claimants and contribute to the view that unemployment is evidence of both personal failure and psychological deficit. The use of psychology in the delivery of workfare functions to erase the experience and effects of social and economic inequalities, to construct a psychological ideal that links unemployment to psychological deficit, and so to authorise the extension of state-and state-contracted-surveillance to psychological characteristics. This paper describes the coercive and punitive nature of many psycho-policy interventions and considers the implications of psycho-policy for the disadvantaged and excluded populations who are its primary targets. We draw on personal testimonies of people experiencing workfare, policy analysis and social media records of campaigns opposed to workfare in order to explore the extent of psycho-compulsion in workfare. This is an area that has received little attention in the academic literature but that raises issues of ethics and professional accountability and challenges the field of medical humanities to reflect more critically on its relationship to psychology.

  1. INDUSTRIAL RISK Programme development

    International Nuclear Information System (INIS)

    INC-DTCI ICIS Rm. Valcea conducts basic and applied research among which there is the INDUSTRIAL RISK Programme that comprises studies of risk analysis and evaluation at objectives and activities in zones were risk factors are in operation, factors leading potentially to natural or technological disasters. The risk analysis and evaluation methodology proposed is a follow-up of the action plan for risk reduction in industry. The risk management refers to risk and its components assessment and identification of places where improvements are to be introduced. The risk analysis and evaluation model was developed for installations in chemical industry and are also applicable for the installations of heavy water production by H2O-H2S isotopic exchange. The risk studies supply information necessary in making decisions, aiming at preventing the operation incidence and reducing their consequences

  2. Photovoltaic programme - edition 2003

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This publication issued by the Swiss Federal Office of Energy's Photovoltaics (PV) Programme presents an overview (in English) of activities and projects in the photovoltaics research and pilot and demonstration area in Switzerland. Progress in the area of future solar cell technologies, modules and building integration, system technologies, planning and operating aids is summarised. Also, PV for applications in developing countries, thermo-photovoltaics and international co-operation are commented on. In the area of pilot and demonstration projects, component development, PV integration in sloping roofs, on flat roofs and noise barriers as well as further PV plant are looked at. Also, measurement campaigns, studies, statistics and further PV-related topics are summarised. This volume also presents the abstracts of reports made by the project managers of 73 research and pilot and demonstration projects in these areas for 2002.

  3. Positive affect as coercive strategy: conditionality, activation and the role of psychology in UK government workfare programmes.

    Science.gov (United States)

    Friedli, Lynne; Stearn, Robert

    2015-06-01

    Eligibility for social security benefits in many advanced economies is dependent on unemployed and underemployed people carrying out an expanding range of job search, training and work preparation activities, as well as mandatory unpaid labour (workfare). Increasingly, these activities include interventions intended to modify attitudes, beliefs and personality, notably through the imposition of positive affect. Labour on the self in order to achieve characteristics said to increase employability is now widely promoted. This work and the discourse on it are central to the experience of many claimants and contribute to the view that unemployment is evidence of both personal failure and psychological deficit. The use of psychology in the delivery of workfare functions to erase the experience and effects of social and economic inequalities, to construct a psychological ideal that links unemployment to psychological deficit, and so to authorise the extension of state-and state-contracted-surveillance to psychological characteristics. This paper describes the coercive and punitive nature of many psycho-policy interventions and considers the implications of psycho-policy for the disadvantaged and excluded populations who are its primary targets. We draw on personal testimonies of people experiencing workfare, policy analysis and social media records of campaigns opposed to workfare in order to explore the extent of psycho-compulsion in workfare. This is an area that has received little attention in the academic literature but that raises issues of ethics and professional accountability and challenges the field of medical humanities to reflect more critically on its relationship to psychology. PMID:26052120

  4. Evaluating an in-home multicomponent cognitive behavioural programme to manage concerns about falls and associated activity avoidance in frail community-dwelling older people: Design of a randomised control trial [NCT01358032

    Directory of Open Access Journals (Sweden)

    van Rossum Erik

    2011-09-01

    Full Text Available Abstract Background Concerns about falls are frequently reported by older people. These concerns can have serious consequences such as an increased risk of falls and the subsequent avoidance of activities. Previous studies have shown the effectiveness of a multicomponent group programme to reduce concerns about falls. However, owing to health problems older people may not be able to attend a group programme. Therefore, we adapted the group approach to an individual in-home programme. Methods/Design A two-group randomised controlled trial has been developed to evaluate the in-home multicomponent cognitive behavioural programme to manage concerns about falls and associated activity avoidance in frail older people living in the community. Persons were eligible for study if they were 70 years of age or over, perceived their general health as fair or poor, had at least some concerns about falls and associated avoidance of activity. After screening for eligibility in a random sample of older people, eligible persons received a baseline assessment and were subsequently allocated to the intervention or control group. Persons assigned to the intervention group were invited to participate in the programme, while those assigned to the control group received care as usual. The programme consists of seven sessions, comprising three home visits and four telephone contacts. The sessions are aimed at instilling adaptive and realistic views about falls, as well as increasing activity and safe behaviour. An effect evaluation, a process evaluation and an economic evaluation are conducted. Follow-up measurements for the effect evaluation are carried out 5 and 12 months after the baseline measurement. The primary outcomes of the effect evaluation are concerns about falls and avoidance of activity as a result of these concerns. Other outcomes are disability and falls. The process evaluation measures: the population characteristics reached; protocol adherence by

  5. A Randomised Control Trial of the Impact of a Computer-Based Activity Programme upon the Fitness of Children with Autism.

    Science.gov (United States)

    Dickinson, Kathleen; Place, Maurice

    2014-01-01

    The poor levels of fitness in children with autism are prompting concern for the children's future health. This study looked to assess if a computer-based activity programme could improve fitness levels (as reflected in cardiopulmonary function) of these children, and achieve a reduction in their body mass index. In a randomised controlled trial, 50 children with autism (of which 33 were under the age of 11 years and 39 were boys) were allocated to an intervention group which encouraged them to use the Nintendo Wii and the software package "Mario and Sonics at the Olympics" in addition to their routine physical education classes. 50 children with autism (34 under the age of 11 years and 40 being boys) acted as controls. At the end of one year, analysis of the changes in scores using analysis of covariance (ANCOVA) on the Eurofit fitness tests showed that the intervention group had made statistically significant improvement on all tests other than flexibility. These improvements were also significantly better than controls. This type of intervention appears to be an effective addition to standard fitness training in order to help children with autism improve their fitness levels. PMID:25400946

  6. A Randomised Control Trial of the Impact of a Computer-Based Activity Programme upon the Fitness of Children with Autism

    Directory of Open Access Journals (Sweden)

    Kathleen Dickinson

    2014-01-01

    Full Text Available The poor levels of fitness in children with autism are prompting concern for the children’s future health. This study looked to assess if a computer-based activity programme could improve fitness levels (as reflected in cardiopulmonary function of these children, and achieve a reduction in their body mass index. In a randomised controlled trial, 50 children with autism (of which 33 were under the age of 11 years and 39 were boys were allocated to an intervention group which encouraged them to use the Nintendo Wii and the software package “Mario and Sonics at the Olympics” in addition to their routine physical education classes. 50 children with autism (34 under the age of 11 years and 40 being boys acted as controls. At the end of one year, analysis of the changes in scores using analysis of covariance (ANCOVA on the Eurofit fitness tests showed that the intervention group had made statistically significant improvement on all tests other than flexibility. These improvements were also significantly better than controls. This type of intervention appears to be an effective addition to standard fitness training in order to help children with autism improve their fitness levels.

  7. Act No 85 of 18 March 1982 granting the Comitato Nazionale per l'Energia Nucleare a State contribution of 2,890 milliard lire to the 5-year activity programme 1980-1984

    International Nuclear Information System (INIS)

    This Act came into force on 23 March 1982. It provides for the financing of the ENEA's (formerly CNEN) programme of work for the period 1980-1984. It further provides that within one year of its entry into force, the Directorate for Nuclear Safety and Health Protection - DISP (formerly within CNEN) will be set up as an independent, autonomous body, with tasks involving control over activities entailing major risks, including nuclear activities. (NEA)

  8. The Possibility of Social Change and Pop Music in Serbia: Šobaja’s Three Kisses – A Case Study

    Directory of Open Access Journals (Sweden)

    Aleksandar Brkić

    2016-02-01

    Full Text Available Can social change be brought about only in a radical manner? Is a radical manner of bringing about change possible at all? When we say social change, do we mean "revolution"? Is there a different way of looking at social change, and what is the role of elite culture and that of popular culture in these processes? Has the temporally and contextually limited effect of change and guerilla subversion through popular culture proved more effective? This small-scale study aims to raise the question of whether pop music can contribute to positive changes in society, and examines the conditions for this possibility through the case study of Nebojša "Šobaja" Anđelković’s song Three Kisses, declared the biggest music hit of 2009 in Serbia.

  9. Patient Experiences of Structured Heart Failure Programmes

    Directory of Open Access Journals (Sweden)

    Nuala E. Tully

    2010-01-01

    Full Text Available Objectives. Patient experiences of structured heart failure rehabilitation and their views on the important components of heart failure services were examined. Methods. Focus groups were conducted with fifteen participants (men, =12 attending one of two heart failure rehabilitation programmes. Sessions were guided by a semistructured interview schedule covering participants' experiences of the programme, maintenance, and GP role. Focus group transcripts were analysed qualitatively. Results. Participants indicated that rehabilitation programmes substantially met their needs. Supervised exercise sessions increased confidence to resume physical activity, while peer-group interaction and supportive medical staff improved morale. However, once the programme ended, some participants' self-care motivation lapsed, especially maintenance of an exercise routine. Patients doubted their GPs' ability to help them manage their condition. Conclusion. Structured rehabilitation programmes are effective in enabling patients to develop lifestyle skills to live with heart failure. However, postrehabilitation maintenance interventions are necessary to sustain patients' confidence in disease self-management.

  10. SET-Routes programme

    CERN Document Server

    CERN audiovisual service

    2009-01-01

    The SET-Routes programme, launched in 2007 with the goal of attracting girls and young women to careers in science, came to an end in April this year. The result of a collaboration between EMBL, EMBO and CERN, the programme established a network of "ambassadors", women scientists who went out to talk about their careers in science at schools and universities across Europe.

  11. Fusion technology programme

    International Nuclear Information System (INIS)

    KfK participates to the Fusion Technology Programme of the European Community. Most of the work in progress addresses the Next European Torus (NET) and the long term technology aspects as defined in the 82/86 programme. A minor part serves to preparation of future contributions and to design studies on fusion concepts in a wider perspective. The Fusion Technology Programme of Euratom covers mainly aspects of nuclear engineering. Plasma engineering, heating, refueling and vacuum technology are at present part of the Physics Programme. In view of NET, integration of the different areas of work will be mandatory. KfK is therefore prepared to address technical aspects beyond the actual scope of the physics experiments. The technology tasks are reported project wise under title and code of the Euratom programme. Most of the projects described here are shared with other European fusion laboratories as indicated in the table annexed to this report. (orig./GG)

  12. Auditing as method of QA programme evaluation

    International Nuclear Information System (INIS)

    The status and adequacy of a quality assurance programme should be regularly reviewed by the cognizant management. The programme audit is an independent review to determine the compliance with respective quality assurance requirements and to determine the effectiveness of that programme. This lecture gives an introduction of the method to perform audits under the following topics: 1. Definition and purpose of quality audits. 2. Organization of the quality audit function. 3. Unique requirements for auditors. 4. Audit preparation and planning. 5. Conduct of the audit. 6. Reporting the audit results. 7. Follow-up activities. (RW)

  13. Country programme review Republic of Cameroon

    International Nuclear Information System (INIS)

    A multi-disciplinary country programme review and programming mission was undertaken to the Republic of Cameroon, from 21 to 25 June 1993. This report reflects the findings and recommendations of the mission and falls into four sections. The first section describes the country profile and includes information about its economy and its development plans and policies. The second reviews the Agency's past and present technical co-operation programmes in Cameroon. The third section deals with a sectoral programme and institutional review, and the fourth section presents possible future technical co-operation activities

  14. A process evaluation of a supervisory development programme

    Directory of Open Access Journals (Sweden)

    Jasper Buys

    2012-07-01

    Full Text Available Orientation: An important evaluation function is to assess the adequacy of the programme process, including the extent to which the appropriate people participate in its activities.Research purpose: The study aimed to provide information about coverage, service delivery, organisational resources, and medium-term outcomes for a supervisory development programme (SDP in the hospitality industry.Motivation for the study: The primary motivation was to assist programme staff to understand their programme and also to generate information that the programme staff could use to reflect on the programme’s performance and future direction.Research design, approach and method: A mixture of quantitative and qualitative methods was employed, namely: a literature review; personal interviews; and internal programme documentation, such as e-mail correspondence, financial statements, attendance registers, and personnel records. Personal interviews were conducted with two stakeholders, namely the programme manager and programme administrator. The programme data of 69 participants in the SDP were utilised for the evaluation.Main findings: The evaluation’s main finding concluded that the ‘implemented programme’ was not congruent with the ‘planned programme’.Practical/managerial implications: It is recommended that programme activities and theory should be re-evaluated, as the programme is used mainly as a training programme for new appointees, rather than a management development programme to create a pool of potential supervisors. Programme uptake and output should also be closely aligned. The length of time that people in the pool of potential supervisors had to wait before they were appointed should also be reduced.Contribution/value-add: By explicating the basic programme theory and studying programme implementation, this evaluation serves as a starting point for future evaluations of the SDP.

  15. The European Fusion Programme

    International Nuclear Information System (INIS)

    The European Fusion Programme is coordinated by Euratom and represents a long term cooperative project of Member States of the European Communities in the field of fusion, designed to lead to the joint construction of prototypes. The main lines of the programme proposed for 1982 to 1986 are: (1) the continuation of a strong effort on tokamaks with emphasis on JET construction, operation and upgrading, (2) conceptual design of NET and development of the related technology, and (3) further work on two alternative magnetic confinement systems. The current status and future plans for this programme are discussed in the paper. (author)

  16. Day-night and reproductive cycle profiles of melatonin receptor, kiss, and gnrh expression in orange-spotted grouper (Epinephelus coioides).

    Science.gov (United States)

    Chai, Ke; Liu, Xiaochun; Zhang, Yong; Lin, Haoran

    2013-07-01

    It is suggested that the MT1 melatonin receptor mediates the effects of melatonin on reproduction in rodents. Three melatonin receptor types, MT1, MT2, and Mel1c, have been identified in fish. To understand the potential roles of each type of melatonin receptor on reproduction, we explored the day-night and reproductive cycle profiles of melatonin receptor, kiss, and gnrh expression in the orange-spotted grouper (Epinephelus coioides). cDNAs encoding melatonin receptors (MT1, MT2, and Mel1c) were first isolated from the brain of the orange-spotted grouper. Quantitative real-time PCR analysis demonstrated that the expression levels of MT1 and MT2 were higher in most of the brain areas and pituitary, while mel1c mRNA was mainly distributed in some peripheral tissues and the pituitary. The expression levels of MT1 were much higher than those of MT2 and mel1c in most of the brain regions, and the day-night expression variations of MT1 were counter to those of kiss2 and gnrh1. Reproductive cycle variations in MT1 daytime expression were different from those for kiss2 and gnrh1, and contrary to ovarian fecundity. Our results suggest that MT1 may modulate gnrh1 expression through kiss2, or may directly influence it. Together, these signal cascades may regulate the seasonal breeding of the orange-spotted grouper. As the day-length variations were consistent with the ovarian fecundity variation observed during the reproductive cycle, we infer that photoperiod affects ovarian development of the orange-spotted grouper through MT1.

  17. Aminoglycoside binding to the HIV-1 RNA dimerization initiation site: thermodynamics and effect on the kissing-loop to duplex conversion

    OpenAIRE

    Bernacchi, Serena; Freisz, Séverine; Maechling, Clarisse; Spiess, Bernard; Marquet, Roland; Dumas, Philippe; Ennifar, Eric

    2007-01-01

    Owing to a striking, and most likely fortuitous, structural and sequence similarity with the bacterial 16 S ribosomal A site, the RNA kissing-loop complex formed by the HIV-1 genomic RNA dimerization initiation site (DIS) specifically binds 4,5-disubstituted 2-deoxystreptamine (2-DOS) aminoglycoside antibiotics. We used chemical probing, molecular modeling, isothermal titration calorimetry (ITC) and UV melting to investigate aminoglycoside binding to the DIS loop–loop complex. We showed that ...

  18. Proposal of a programme for leisure education

    OpenAIRE

    Urban, Jindřich

    2013-01-01

    The submitted bachelor thesis with the title of Proposal of a programme for leisure education reacts on urgent needs in the area of meaningful spending of young people's leisure time. By its practical focus, it represents selected ways for possible management of leisure time activity oriented on sport fishing. The main aim of the thesis is to propose programme for a fishing club, i.e. presentation of thirteen elaborated thematic areas that are considered as fundamental in fishing sport. E...

  19. Photovoltaic programme, edition 2004

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This comprehensive publication issued by the Swiss Federal Office of Energy's Photovoltaics (PV) Programme presents an overview (in English) of activities and projects in the photovoltaics research and pilot and demonstration areas in Switzerland for the year 2003. Progress in future solar cell technologies as well as in the area of modules, building integration and system technologies is summarised. Also, national and international co-operation and multi-national pilot and demonstration projects are commented on. Associated projects such as eco-balances for PV systems, forecasting and modelling tools as well as system monitoring tools are discussed. In the area of pilot and demonstration projects, component development, PV integration in sloping roofs, on flat roofs and on facades as well as further PV plant are looked at. Also, measurement campaigns, studies, statistics and other PV-related topics are summarised. This volume presents a list of 92 projects in the PV area including the appropriate Internet links and is completed with a collection of project abstracts.

  20. Network virtualization and programmability

    OpenAIRE

    Colle, Didier; Jooris, Bart; Gurzi, Pasquale; Pickavet, Mario; Demeester, Piet

    2010-01-01

    We present network virtualization (building virtual or logical networks over a physical infrastructure) and network programmability (allowing the network operator to at least control the network but more fundamentally to define its behavior) concepts.

  1. Fellows, Associates & Students Programmes

    CERN Document Server

    2005-01-01

    The present document reviews the CERN Fellows, Associates and Students Programmes emphasizing the developments since 2000, when the previous review was presented to the Scientific Policy Committee, Finance Committee and Council (CERN/2325), and makes proposals for the coming five years. In summary, it is proposed to â?¢ Simplify the payment scheme for the Paid Scientific Associates Programme, which will no longer depend on candidateâ??s home support and age; â?¢ Broaden the scope of the Fellowship Programme, in order to facilitate the recruitment of young graduates in computing and engineering. Age-related eligibility conditions and payment levels will be replaced with experience-based criteria; â?¢ Modify subsistence rates for the Doctoral and Technical Student Programme in order to harmonize CERNâ??s payment levels with those offered by other research establishments. This document is presented for discussion and recommendation by the Scientific Policy Committee and approval by the Council. Additiona...

  2. Elukestva õppe programm : Erasmus+

    Index Scriptorium Estoniae

    2014-01-01

    Erasmus+ programm liidab senised koostööprogrammid „Euroopa elukestva õppe programm“, „Euroopa Noored“ ning Euroopa komisjoni rahvusvahelised kõrgharidusprogrammid. Elukestva õppe programmi 2013 kokkuvõte

  3. Position of the kissing-loop interaction associated with PTE-type 3’CITEs can affect enhancement of cap-independent translation

    Science.gov (United States)

    Chattopadhyay, Maitreyi; Kuhlmann, Micki M.; Kumar, Kalyani; Simon, Anne E.

    2014-01-01

    The Panicum mosaic virus-like translation enhancer (PTE) functions as a cap-independent translation enhancer (3’CITE) in members of several Tombusviridae genera including 7/19 carmoviruses. For nearly all PTE, a kissing-loop connects the element with a hairpin found in several conserved locations in the genomic RNA (5’ terminal hairpin or ~100 nt from the 5’end) and small subgenomic RNA (~63 nt from the 5’end). Moving the interaction closer to the 5’end in reporter mRNAs using Saguaro cactus virus (SCV) sequences had either a minimal or substantial negative effect on translation. Movement of the kissing loop from position 104 to the SCV 5’ terminal hairpin also reduced translation by 4-fold. These results suggest that relocating the PTE kissing loop closer to the 5’end reduces PTE efficiency, in contrast to results for the Barley yellow dwarf BTE and Tomato bushy stunt virus Y-shaped 3’CITEs , suggesting that different 3’CITEs have different bridging requirements. PMID:24928038

  4. Cold exposure inhibits hypothalamic Kiss-1 gene expression, serum leptin concentration, and delays reproductive development in male Brandt's vole ( Lasiopodomys brandtii)

    Science.gov (United States)

    Zhang, Qiang; Lin, Yi; Zhang, Xue-Ying; Wang, De-Hua

    2015-06-01

    Cold commonly affects growth and reproductive development in small mammals. Here, we test the hypothesis that low ambient temperature will affect growth and puberty onset, associated with altered hypothalamic Kiss-1 gene expression and serum leptin concentration in wild rodents. Male Brandt's voles ( Lasiopodomys brandtii) were exposed to cold (4 ± 1 °C) and warm (23 ± 1 °C) conditions from the birth and sacrificed on different developmental stages (day 26, day 40, day 60, and day 90, respectively). Brandt's voles increased the thermogenic capacity of brown adipose tissue, mobilized body fat, decreased serum leptin levels, and delayed the reproductive development especially on day 40 in the cold condition. They increased food intake to compensate for the high energy demands in the cold. The hypothalamic Kiss-1 gene expression on day 26 was decreased, associated with lower wet testis mass and testis testosterone concentration on day 40, in the cold-exposed voles compared to that in the warm. Serum leptin was positively correlated with body fat, testis mass, and testosterone concentration. These data suggested that cold exposure inhibited hypothalamic Kiss-1 gene expression during the early stage of development, decreased serum leptin concentration, and delayed reproductive development in male Brandt's voles.

  5. Development of a training programme for home health care workers to promote preventive activities focused on a healthy lifestyle : an intervention mapping approach

    NARCIS (Netherlands)

    Walters, Maaike E.; Dijkstra, Arie; de Winter, Andrea F.; Reijneveld, Sijmen A.

    2015-01-01

    Background: Lifestyle is an important aspect in maintaining good health in older adults, and home health care (HHC) workers can play an important role in promoting a healthy lifestyle. However, there is limited evidence in the literature regarding how to develop an effective training programme to im

  6. The European Framework Programme under way

    CERN Multimedia

    2007-01-01

    The new European Framework Programme - FP7 - has recently started and will offer various possibilities for CERN to participate in EU co-funded projects for research and technological development. In December 2006, the Council of the European Union (EU) formally adopted the 7th European Framework Programme for research, technological development and demonstration activities (FP7). FP7 started on 1 January 2007 and will cover the period 2007 to 2013. With a total budget of 50.5 B-Euros, FP7 is the largest Framework Programme in the history of the EU. FP7 consists of four major sub-programmes, referred to as 'Specific Programmes'. 'Cooperation' is focused on collaborative research and is divided into 10 research themes. 'Ideas' is a new EU programme for funding of frontier research in all fields of science. 'Capacities' aims at strengthening the research capacities in Europe. Finally, 'People' succeeds the previous Marie Curie Programmes and targets the development of Europe's human potential. On 22 December...

  7. The European Framework Programme under way

    CERN Multimedia

    2007-01-01

    The new European Framework Programme - FP7 - has recently started and will offer various possibilities for CERN to participate in EU co-funded projects for research and technological development. In December 2006, the Council of the European Union (EU) formally adopted the 7th European Framework Programme for research, technological development and demonstration activities (FP7). FP7 started on 1st January 2007 and will cover the period 2007 to 2013. With a total budget of 50.5 billion euros, FP7 is the largest Framework Programme in the history of the EU. FP7 consists of four major sub-programmes, referred to as 'Specific Programmes'. 'Cooperation' is focused on collaborative research and is divided into 10 research themes. 'Ideas' is a new EU programme for funding frontier research in all fields of science. 'Capacities' aims at strengthening the research capacities in Europe. Finally, 'People' succeeds the previous Marie Curie Programmes and targets the development of Europe's human potential. On 22 Decem...

  8. Punch Card Programmable Microfluidics

    OpenAIRE

    George Korir; Manu Prakash

    2014-01-01

    Small volume fluid handling in single and multiphase microfluidics provides a promising strategy for efficient bio-chemical assays, low-cost point-of-care diagnostics and new approaches to scientific discoveries. However multiple barriers exist towards low-cost field deployment of programmable microfluidics. Incorporating multiple pumps, mixers and discrete valve based control of nanoliter fluids and droplets in an integrated, programmable manner without additional required external component...

  9. Stay Safe Programme

    OpenAIRE

    MacIntyre, Deirdre; Carr, Alan.

    1999-01-01

    Objective. This child abuse prevention study aimed to evaluate the effectiveness of the Stay Safe Programme in training unscreened 7 and 10 year old children in personal safety skills. Subsidiary aims were to evaluate the programme's impact on children's self-esteem and parents' and teachers' knowledge and attitudes of relevance to child abuse and protection. Method. Changes in safety knowledge and skills and self-esteem of 339 children who participated in the Stay Safe Program...

  10. The Gold Standard Programme

    DEFF Research Database (Denmark)

    Neumann, Tim; Rasmussen, Mette; Ghith, Nermin;

    2013-01-01

    To evaluate the real-life effect of an evidence-based Gold Standard Programme (GSP) for smoking cessation interventions in disadvantaged patients and to identify modifiable factors that consistently produce the highest abstinence rates.......To evaluate the real-life effect of an evidence-based Gold Standard Programme (GSP) for smoking cessation interventions in disadvantaged patients and to identify modifiable factors that consistently produce the highest abstinence rates....

  11. Programmable Multi-Chip Module

    Science.gov (United States)

    Kautz, David; Morgenstern, Howard; Blazek, Roy J.

    2004-11-16

    A multi-chip module comprising a low-temperature co-fired ceramic substrate having a first side on which are mounted active components and a second side on which are mounted passive components, wherein this segregation of components allows for hermetically sealing the active components with a cover while leaving accessible the passive components, and wherein the passive components are secured using a reflow soldering technique and are removable and replaceable so as to make the multi-chip module substantially programmable with regard to the passive components.

  12. Experience from the Inspection of Licensees' Outage Activities, Including Fire Protection Programmes, Event Response Inspections, and the Impact of the Fukushima Daiichi NPP Accident on Inspection Programmes. Workshop Proceedings, Chattanooga, Tennessee, United States, 7-10 April 2014 - Appendix: Compilation of Survey Responses

    International Nuclear Information System (INIS)

    This appendix provides the complete compilation of responses received to the questionnaire issued in conjunction with the workshop announcements. The responses are provided as received, with changes made only to the formatting. The OECD Nuclear Energy Agency (NEA) Committee on Nuclear Regulatory Activities (CNRA) Working Group on Inspection Practices (WGIP) sponsored the 12. International Workshop on Nuclear Regulatory Inspection Activities. The workshop was hosted by the U.S. NRC, in Chattanooga, Tennessee, United States of America on 7 -10 April 2014. The three workshop topics that were addressed were as follows: - Inspection of Outage Activities Including Fire Protection Programmes. - Event Response Inspections. - The Impact of Inspection Programmes of the Fukushima Daiichi NPP Accident. Each of the respondents was given the following instructions in relation to their response: - Only one response per country is required. If more than one person from your country is participating, please co-ordinate the responses accordingly. - Please provide responses on separate sheet and clearly identify the questionnaire part and topic. For preparation of the workshop, participants are invited to supply their national inspection approaches used in inspection of events and incidents according to the surveys. Actual issues that were discussed during the workshop were generated by the topic leaders based on the responses submitted by participants with their registration forms. This formats helps to ensure that issues considered most important by the workshop participants are covered during the group discussions. (authors)

  13. IAEA programme on research reactor safety

    International Nuclear Information System (INIS)

    This paper describes the IAEA programme on research reactor safety and includes the safety related areas of conversions to the use of low enriched uranium (LEU) fuel. The program is based on the IAEA statutory responsibilities as they apply to the requirements of over 320 research reactors operating around the world. The programme covers four major areas: (a) the development of safety documents; (b) safety missions to research reactor facilities; (c) support of research programmes on research reactor safety; (d) support of Technical Cooperation projects on research reactor safety issues. The demand for these activities by the IAEA member states has increased substantially in recent years especially in developing countries with increasing emphasis being placed on LEU conversion matters. In response to this demand, the IAEA has undertaken an extensive programme for each of the four areas above. (author)

  14. Status of national gas cooled reactor programmes

    International Nuclear Information System (INIS)

    This report has been compiled as a central source of summary-level information on the present status of High Temperature Gas-Cooled Reactor (HTGR) programmes in the world and on future plans for the continued development and deployment of HTGRs. Most of the information concerns the programmes in the United States, Germany, Japan and the Soviet Union, countries that have had large programmes related to HTGR technology for several years. Summary-level information is also provided in the report on HTGR-related activities in several other countries who either have an increasing interest in the technology and/or who are performing some development efforts related to HTGR technology. The report contains a summary-level update on the MAGNOX and AGR programmes. This is the twelfth issue of the document, the first of which was issued in March, 1979. The report has been prepared in the IAEA Nuclear Power Technology Development Section. Figs and tabs

  15. Control programme for cystic echinococcosis in Uruguay

    Science.gov (United States)

    Irabedra, Pilar; Ferreira, Ciro; Sayes, Julio; Elola, Susana; Rodríguez, Miriam; Morel, Noelia; Segura, Sebastian; dos Santos, Estela; Guisantes, Jorge A

    2016-01-01

    Cystic echinococcosis is a highly endemic parasitic zoonosis that is present in the Southern Cone countries of America. For several decades, various prevention and control programmes have been implemented in different countries and regions, with varying results. In Uruguay, a new control programme was implemented in 2006 that employed new strategies for canine diagnosis and treatment, dog population control, diagnosis in humans, epidemiological surveillance, and health education, including community participation. The control programme in Uruguay addresses the control and surveillance of the disease from a holistic perspective based on Primary Health Care, which has strengthened the community’s participation in developing and coordinating activities in an interdisciplinary manner. Similarly, the control programme that is currently implemented is based on a risk-focused approach. The surveillance and control measures were focused on small villages and extremely poor urban areas. In this study, the strategies used and the results obtained from 2008-2013 are analysed and discussed. PMID:27223652

  16. The volunteer programme ‘Night Ravens’:

    DEFF Research Database (Denmark)

    Larsen, Britt Østergaard; Bendix Kleif, Helle; Kolodziejczyk, Christophe

    2015-01-01

    with NR organizations to districts without NR organizations. The results show no difference in the crime rates between Danish postcode districts with and without the NR programme. Hence, we cannot identify positive effects of situational crime prevention when evaluating this Scandinavian volunteer......The volunteer programme ‘Night Ravens’ (NR) was founded in Sweden in 1987 and has, over the years, developed into a Scandinavian concept covering large areas of Sweden, Denmark, Norway, Greenland and the Faroe Islands. The NR programme is a crime prevention initiative with adults walking...... the streets at night in identifiable ‘uniforms’ in areas with high activity. The purpose of this study is to evaluate the effects of the NR programme in Denmark based on a volunteer set-up with a less intrusive approach to situational crime prevention than, for instance, hot spot policing. The analyses...

  17. Status of national programmes on fast reactors

    International Nuclear Information System (INIS)

    Based on the International Working Group on Fast reactors (IWGFR) members' request, the IAEA organized a special meeting on Fast Reactor Development and the Role of the IAEA in May 1993. The purpose of the meeting was to review and discuss the status and recent development, to present major changes in fast reactor programmes and to recommend future activities on fast reactors. The IWGFR took note that in some Member States large prototypes have been built or are under construction. However, some countries, due to their current budget constraints, have reduced the level of funding for research and development programmes on fast reactors. The IWGFR noted that in this situation the international exchange of information and cooperation on the development of fast reactors is highly desirable and stressed the importance of the IAEA's programme on fast reactors. These proceedings contain important and useful information on national programmes and new developments in sodium cooled fast reactors in Member States. Refs, figs and tabs

  18. The CERN & Society programme launches its newsletter

    CERN Multimedia

    Matteo Castoldi

    2016-01-01

    The newsletter will be issued quarterly. Sign up to remain informed about the latest initiatives of the CERN & Society programme!    The CERN & Society programme encompasses projects in the areas of education and outreach, innovation and knowledge exchange, and culture and creativity that spread the CERN spirit of scientific curiosity for the inspiration and benefit of society. The programme is funded primarily by the CERN & Society Foundation, a charitable foundation established by CERN and supported by individuals, trusts, organisations and commercial companies. The projects are inspired or enabled by CERN but lie outside of the Laboratory’s specific research mandate. We especially want to help young talent from around the world to flourish in the future. The programme is now launching its newsletter, which will be issued quarterly. Everybody who wants to be informed about CERN & Society’s activities, stay up-to-date with its latest in...

  19. Outcomes-based planning and implementation led to the success of the Hawaii fruit fly suppression programme: Implications to adoption of area-wide programmes

    International Nuclear Information System (INIS)

    Full text: A critical component of successful area-wide pest management (AWPM) programmes are organised, coordinated and comprehensive outreach educational programmes. The Hawaii area-wide fruit fly pest management (HAW-FLYPM) programme's educational programme, a part of a USDA AWPM programme in Hawaii, utilised the 'logic model' approach to organise, plan, execute and evaluate farmer and community educational programmes statewide. The logic model approach was an outcome-driven rather than activity based method that employed a linear sequence that developed relationships between programme inputs, outputs and outcomes. This model was utilised extensively to transfer sustainable, science-based technologies to suppress tephritid fruit fly pests. HAW-FLYPM's educational programme targeted growers and community door yard growers, three teaching curricula aimed at elementary through high school students, and a statewide awareness programme for the public at large. Additional key components of the HAW-FLYPM education programme was the development of implementation schedules used to track programme progress, a comprehensive media matrix developed to ensure educational materials met the needs of target audience groups, and a sustainability calculator to assess the likelihood of programme sustainability after the initial five year funding cycle. The model served as a 'blue print' for ensuring programme elements were planned, delivered and executed on a timely basis. Utilisation of the logic model to organise efforts and manage diverse, multi agency programmes such as the HAW-FLYPM programme has shown to be a successful method of programme advancement and outcome achievement. (author)

  20. Effectiveness of a universal parental support programme to promote healthy dietary habits and physical activity and to prevent overweight and obesity in 6-year-old children: the Healthy School Start Study, a cluster-randomised controlled trial.

    Directory of Open Access Journals (Sweden)

    Gisela Nyberg

    Full Text Available To develop and evaluate the effectiveness of a parental support programme to promote healthy dietary and physical activity habits and to prevent overweight and obesity in Swedish children.A cluster-randomised controlled trial was carried out in areas with low to medium socio-economic status. Participants were six-year-old children (n = 243 and their parents. Fourteen pre-school classes were randomly assigned to intervention (n = 7 and control groups (n = 7. The intervention lasted for 6 months and included: 1 Health information for parents, 2 Motivational Interviewing with parents and 3 Teacher-led classroom activities with children. Physical activity was measured by accelerometry, dietary and physical activity habits and parental self-efficacy through a questionnaire. Body weight and height were measured and BMI standard deviation score was calculated. Measurements were conducted at baseline, post-intervention and at 6-months follow-up. Group differences were examined using analysis of covariance and Poisson regression, adjusted for gender and baseline values.There was no significant intervention effect in the primary outcome physical activity. Sub-group analyses showed a significant gender-group interaction in total physical activity (TPA, with girls in the intervention group demonstrating higher TPA during weekends (p = 0.04, as well as in sedentary time, with boys showing more sedentary time in the intervention group (p = 0.03. There was a significantly higher vegetable intake (0.26 servings in the intervention group compared to the control group (p = 0.003. At follow-up, sub-group analyses showed a sustained effect for boys. The intervention did not affect the prevalence of overweight or obesity.It is possible to influence vegetable intake in children and girls' physical activity through a parental support programme. The programme needs to be intensified in order to increase effectiveness and sustain the effects long-term. These findings

  1. Observation of a Change in Bend of an RNA Kissing Complex Using the Angular Dependence of Fluorescence Resonance Energy Transfer

    CERN Document Server

    Rahmanseresht, Sheema; Gamari, Ben D; Goldner, Lori S

    2014-01-01

    We report on the observation of a change in the bend angle of an RNA kissing complex upon Rop binding using single-molecular-pair FRET. The angular relationship between the dyes, rather than the distance between them, is shown to be responsible for the observed change in energy transfer. It has long been thought that Rop increases the bend angle of the R1inv-R2inv complex upon binding, but this has never been directly observed. In contrast, we find an increase in FRET upon the addition of Rop that is shown via modeling to be consistent with a decrease in the bend angle of the complex of $-15^{\\circ}\\pm7^{\\circ}$. The model predicts FRET from dye trajectories generated using molecular dynamics simulations of Cy3 and Cy5 attached to $5'$ terminal cytosine or guanosine on RNA. While FRET is commonly used to observe global changes in molecular structure attributed to changes in the distance between dyes, it is rarely, if ever, used to elucidate angular changes. Subtle global changes in molecular structure upon bi...

  2. Effect of Final Kissing Balloon Dilatation after One-stent Technique at Left-main Bifurcation: A Single Center Data

    Directory of Open Access Journals (Sweden)

    Zhan Gao

    2015-01-01

    Full Text Available Background: Whether final kissing balloon (FKB dilatation after one-stent implantation at left-main (LM bifurcation site remains unclear. Therefore, this large sample and long-term follow-up study comparatively assessed the impact of FKB in patients with unprotected LM disease treated with one-stent strategy. Methods: Total 1528 consecutive patients underwent LM percutaneous coronary intervention in one center from January 2004 to December 2010 were enrolled; among them, 790 patients treated with one drug-eluting stent crossover LM to left anterior descending (LAD with FKB (n = 230 or no FKB (n = 560 were comparatively analyzed. Primary outcome was the rate of major adverse cardiovascular events, defined as a composite of death, myocardial infarction (MI and target vessel revascularization (TVR. Results: Overall, The prevalence of true bifurcation lesions, which included Medina classification (1,1,1, (1,0,1, or (0,1,1, was similar between-groups (non-FKB: 37.0% vs. FKB: 39.6%, P = 0.49. At mean 4 years follow-up, rates of major adverse cardiovascular events (non-FKB: 10.0% vs. FKB: 7.8%, P = 0.33, death, MI and TVR were not significantly different between-groups. In multivariate propensity-matched regression analysis, FKB was not an independent predictor of adverse outcomes. Conclusions: For patients treated with one-stent crossover LM to LAD, clinical outcomes appear similar between FKB and non-FKB strategy.

  3. External Mobility Programme

    CERN Multimedia

    HR Department

    2007-01-01

    Every year, a significant number of highly-skilled staff members leave the Organization and offer their talents on the European job market. CERN is launching a programme aiming to help staff members to whom the Organization cannot offer an indefinite contract in the transition towards their next employment. The programme, which is based on the establishment of a number of partnerships with potential employers in the private sector, will run on a voluntary basis. Staff members who have received confirmation that they will not be offered an indefinite contract and who are interested in availing themselves of the opportunities offered by the programme, are invited to enrol by following the procedure described at: https://ert.cern.ch/browse_intranet/wd_pds?p_web_page_id=5841 Applications will be processed in the strictest confidence by the Human Resources Department and eligible profiles will then be made available to partner companies for recruitment purposes. Any subsequent ...

  4. Punch Card Programmable Microfluidics

    CERN Document Server

    Korir, George

    2014-01-01

    Small volume fluid handling in single and multiphase microfluidics provides a promising strategy for efficient bio-chemical assays, low-cost point-of-care diagnostics and new approaches to scientific discoveries. However multiple barriers exist towards low-cost field deployment of programmable microfluidics. Incorporating multiple pumps, mixers and discrete valve based control of nanoliter fluids and droplets in an integrated, programmable manner without additional required external components has remained elusive. Combining the idea of punch card programming with arbitrary fluid control, here we describe a self-contained, hand-crank powered, multiplex and robust programmable microfluidic platform. A paper tape encodes information as a series of punched holes. A mechanical reader/actuator reads these paper tapes and correspondingly executes a series of operations onto a microfluidic chip coupled to the platform in a plug-and-play fashion. Enabled by the complexity of codes that can be represented by a series ...

  5. Finnish Fusion Research Programme Yearbook 1993-1994

    International Nuclear Information System (INIS)

    Finnish Fusion Research Programme (FFUSION) is one of the national energy research programmes funded by the Ministry of Trade and Industry and from 1995 by TEKES. National organization for fusion research is necessary for efficient and successful participation in international fusion programmes. FFUSION programme serves well for this purpose and it made possible to establish relations and the dialogue with the European Fusion Programme. The process led to the Finnish Association Euratom-TEKES in early 1995. The first period of the FFUSION programme (1993-1994) was preparation for the association to the Community Programme. The strategy was to emphasize fusion technology parallel with the basic fusion and plasma physics and to activate the related Finnish industry to collaborate and participate in the FFUSION programme and later in the European Fusion Programme. The key element in the strategy is the focusing our fairly small R and D effort to a few topics, which increases possibilities to be competitive in Europe. The physics programme in FFUSION deals mainly with theoretical and computational studies of radio-frequency heating in tokamak plasmas. Technology programme started with prestudies in 1993 and it concentrates into two areas: fusion reactor materials and remote handling systems. (8 figs., 3 tabs.)

  6. Funktionell Programmering : En framtidsprognos

    OpenAIRE

    Holmer, Mattias

    2011-01-01

    Trenden inom systemutveckling och programutveckling går mot ett mer användande av multi programmeringsparadigmer. Funktionell programmering har fått mer uppmärksamhet på senare tid och utvecklingen tycks över lag gå än mer åt det deklarativa hållet där programmeraren fokuserar mer på vad som skall utföras och inte lika mycket på hur. Under en tid har det objektorienterade paradigmet varit dominerande, kommer det vara så i framtiden? Funktionell programmering skiljer sig från imperativ program...

  7. Computer mathematics for programmers

    CERN Document Server

    Abney, Darrell H; Sibrel, Donald W

    1985-01-01

    Computer Mathematics for Programmers presents the Mathematics that is essential to the computer programmer.The book is comprised of 10 chapters. The first chapter introduces several computer number systems. Chapter 2 shows how to perform arithmetic operations using the number systems introduced in Chapter 1. The third chapter covers the way numbers are stored in computers, how the computer performs arithmetic on real numbers and integers, and how round-off errors are generated in computer programs. Chapter 4 details the use of algorithms and flowcharting as problem-solving tools for computer p

  8. A programmer's geometry

    CERN Document Server

    Bowyer, Adrian

    1983-01-01

    A Programmer's Geometry provides a guide in programming geometric shapes. The book presents formulas and examples of computer representation and coding of geometry. Each of the nine chapters of the text deals with the representation and solution of a specific geometrical problem, such as areas, vectors, and volumes. The last chapter provides a brief discussion on generating image through a computer. The codes presented in the book are written in FORTRAN 77. The text will be of great use to programmers who are working on projects that involve geometric calculations.

  9. Dragon 2 Programme Achievements and Cooperation

    Science.gov (United States)

    Desnos, Yves-Louis; Li, Zengyuan; Zmuda, Andy; Gao, Zhihai

    2013-01-01

    The cooperation between ESA and National Remote Sensing Center of China (NRSCC) / Ministry of Science and Technology of China (MOST) in the development of Earth Observation (EO) applications started 17 years ago. In 2004, a new phase in cooperation began with the start of the Dragon Programme which focused on science and application using ESA ERS and Envisat satellite data. The programme was completed in 2008. Following on, the cooperation took on greater momentum with the start of a four-year EO science and exploitation programme called “Dragon 2”. The programme formally closed in June at the 2012 Beijing Symposium. The programme brought together joint Sino-European teams to investigate land, ocean and atmospheric applications in P.R. China using EO data from ESA, Third Party Mission (TPM) and Chinese satellites. The teams were led by principal EO scientists. Young European and Chinese scientists were also engaged on the projects. Advanced training courses in land, ocean and atmospheric applications were held in each year of the programme in China. Altogether, two courses on land, one course on atmospheric applications and one course on oceanographic applications were held. Here-in provided is an overview of the achievements, cooperation, reporting and training activities at the completion of the programme. The Sino-European teams have delivered world-class scientific results across a wide range of disciplines. The programme provided a platform for the joint exploitation of ESA, TPM and Chinese EO data from optical, thermal and microwave sensors for geo-science application and development in China.

  10. International Programmes on ADS: IAEA

    International Nuclear Information System (INIS)

    The IAEA recognizes that there are four major challenges facing the long term development of nuclear energy as a part of the world’s energy mix: improvement of the economic competitiveness, meeting increasingly stringent safety requirements, adhering to the criteria of sustainable development, and public acceptance. Meeting the sustainability criteria is the driving force behind IAEA’s activity in the area of innovative transmutation reactor technology development and, in particular, Accelerator Driven Systems. The framework for all the IAEA activities in the ADS area is the Technical Working Group on Fast Reactors (TWG-FR). In response to strong common R&D needs in the Member States, the TWG-FR acts as a catalyst for international information exchange and collaborative R&D. It provides a forum for exchange of non-commercial scientific and technical information, and a forum for international cooperation on generic research and development programmes on advances in fast reactors and fast spectrum accelerator driven systems. Its present members are the following 15 IAEA Member States: Belarus, Brazil, China, France, Germany, India, Italy, Japan, Kazakhstan, Republic of Korea, Russian Federation, Sweden, Switzerland, United Kingdom, and United States of America, as well as 3 international organizations: ISTC, OECD-NEA, and EU (EC). As observers, the TWG-FR has welcomed Argentina and Belgium. Last but not least, the IAEA is providing the ADS Research and Development Database. It contains information about ADS related R&D programmes, existing and planned experimental facilities as well as programmes, methods and data development efforts, design studies, and so forth

  11. Mexican medfly programme

    International Nuclear Information System (INIS)

    This film tells the story of the fight against and final extinction of the Mediterranean fruit-fly (Ceratitis capitata) in Mexico. By producing billions of high quality sterile flies in the Medfly reproduction and sterilization laboratory in the province of Chiapas and releasing them over infested areas, the Moscamed Programme succeeded in eradicating this pest from Mexico in 1982

  12. Kulturalistische Unternehmensethik : ein Programm

    OpenAIRE

    Hanekamp, Gerd

    2001-01-01

    "Das Programm einer kulturalistischen Unternehmensethik wird vorgestellt. Es gründet auf einem philosophischen Ansatz, der sich als instrumentalistisch, kontextualistisch, transsubjektivistisch und individualistisch charakterisieren lässt. Hinsichtlich der ethischen Grundlagen werden starke Thesen durch den Rekurs auf eine kontextualistisch-normative Anthropologie vermieden." (Autorenreferat)

  13. The European Programme Manager

    DEFF Research Database (Denmark)

    Larson, Anne; Bergman, E.; Ehlers, S.;

    The publication is a result of a cooperation between organisations in six European countries with the aim to develop a common European education for programme managers. It contains of a description of the different elements of the education together with a number of case-studies from the counties...

  14. Air Quality Monitoring Programme

    DEFF Research Database (Denmark)

    Kemp, K.; Palmgren, F.

    The Danish Air Quality Monitoring Programme (LMP IV) has been revised in accordance with the Framework Directive and the first three daughter directives of SO2, NOx/NO2, PM10, lead, benzene, CO and ozone. PM10 samplers are under installation and the installation will be completed during 2002...

  15. Progressive Retirement Programme

    CERN Multimedia

    HR Department

    2007-01-01

    Following discussion at the Standing Concertation Committee at its meeting on 30 January 2007, the Director-General has approved the extension of the Progressive Retirement Programme with effect from 1 April 2007 until 31 March 2008. Human Resources Department Tel. 74484/74128

  16. Fast reactor programme

    International Nuclear Information System (INIS)

    This progress report summarises the fast reactor research carried out at the Netherlands Energy Research Centre during the year 1981. The neutron and fission product cross sections of various isotopes have been evaluated. In the fuel performance programme, some preliminary results are given and irradiation facilities described. Creep experiments on various stainless steel components are reported

  17. En model for programmer

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak

    Dette undervisningsmateriale beskriver en model for, hvordan programmer er opbygget. Materialet er skrevet til brug i det gymnasiale forsøgsfag Informationsteknologi. Seneste version af dette undervisningsmateriale kan findes på http:// www.imhotep.dk. Tak til Elisabeth Husum for en kritisk...

  18. Framework Programmable Platform for the Advanced Software Development Workstation (FPP/ASDW). Demonstration framework document. Volume 1: Concepts and activity descriptions

    Science.gov (United States)

    Mayer, Richard J.; Blinn, Thomas M.; Dewitte, Paul S.; Crump, John W.; Ackley, Keith A.

    1992-01-01

    The Framework Programmable Software Development Platform (FPP) is a project aimed at effectively combining tool and data integration mechanisms with a model of the software development process to provide an intelligent integrated software development environment. Guided by the model, this system development framework will take advantage of an integrated operating environment to automate effectively the management of the software development process so that costly mistakes during the development phase can be eliminated. The Advanced Software Development Workstation (ASDW) program is conducting research into development of advanced technologies for Computer Aided Software Engineering (CASE).

  19. Supporting mothers: issues in a Community Mothers Programme

    OpenAIRE

    O'Connor, Pat

    2001-01-01

    peer-reviewed This article describes a community support programme which implicitly challenges the assumption that the existence of a partner and local kin obviates the need to support women when they come home from hospital with a new baby. Implicit in the programme is the idea that support by mothers, of mothers, validates the activity of child care and is one way of facilitating the child's development. This programme was successful in terms of its perceived impact on both the providers...

  20. Importance of outcomes Measurement of CSR programmes - Case Nokia

    OpenAIRE

    Talvitie-Sirén, Reeta

    2009-01-01

    Abstract: Objectives of the Thesis The objective of the thesis was to find out how companies measure the societal and business outcomes of their CSR activities as well as to find out the reasons why outcomes measurement is considered important. The focus was on the societal aspect of CSR, and all programmes studied were community related CSR programmes. The programmes studied were categorised according to a framework of CSR action types modified from Halme and Laurila (2009). A fourth cate...

  1. Evaluating the effectiveness of a schools-based programme to promote exercise self-efficacy in children and young people with risk factors for obesity: Steps to active kids (STAK

    Directory of Open Access Journals (Sweden)

    Yang Min

    2011-10-01

    Full Text Available Abstract Background Low levels of physical activity in children have been linked to an increased risk of obesity, but many children lack confidence in relation to exercise (exercise self-efficacy. Factors which can impact on confidence include a chronic health condition such as asthma, poor motor skills and being overweight. Increasing levels of physical activity have obvious benefits for children with asthma and children who are overweight, but few activity interventions with children specifically target children with low exercise self-efficacy (ESE. This study aims to evaluate the efficacy and feasibility of a schools-based activity programme suitable for children with risk factors for adult obesity, including asthma, overweight and low exercise self-efficacy. Methods/Design A clustered (at the level of school RCT will be used to compare a targeted, 10 week, stepped activity programme (activity diary, dance DVD, circuit-training and motivational interviewing designed to promote ESE. We will recruit 20 primary schools to participate in the intervention and 9-11 year old children will be screened for low levels of ESE, asthma and overweight. In order to provide sufficient power to detect a difference in primary outcomes (Body Mass Index-BMI & ESE at 12 month follow-up between children in the intervention schools and control schools, the target sample size is 396. Assessments of BMI, ESE, waist circumference, peak flow, activity levels and emotional and behavioural difficulties will be made at baseline, 4 months and 12 month follow-up. Discussion We aim to increase ESE and levels of physical activity in children with risk factors for adult obesity. The outcomes of this study will inform policy makers about the feasibility, acceptability and effectiveness of delivering targeted health interventions within a school setting. Trial Registration ISRCTN Register no. ISRCTN12650001

  2. Expressions of hypothalamic KISS-1 and G protein-couple receptor 54 genes in female rats with precocious puberty%KISS-1和GPR54基因在雌性性早熟大鼠下丘脑中的表达

    Institute of Scientific and Technical Information of China (English)

    葛伟; 王海莲; 薛江

    2012-01-01

    Objective To investigate expressions of hypothalamic KISS-1 and G protein-couple receptor 54 (GPR54) genes in female rats with precocious puberty and their effects on development of precocious puberty. Methods Fifty 26-day-old female rats were randomly divided into 5 groups, the first experimental group, the second experimental group, the first control group, the second control group, and the third control group. Experimental groups received a subcutaneous injection of N-methyl-DL-aspartate acid (NMA) twice a day until vaginal opening(VO) occurred, while control groups received normal saline. Parameters of puberty were analyzed, including the day of VO, estrous cycle of the rat, index of the ovary, index of the uterus, incidence of the corpora lutea, thickness of the uterus and serum lutein-izing hormone(LH). Expressions of hypothalamic KISS-1 and GPR54 genes in the five groups were detected by Realtime reverse transcription polymerase chain reaction (Real-time RT-FCR). Results The age of VO and first diestrus in experimental groups were earlier than in control groups(P<0.05). All parameters of puberty gradually increased with the development of puberty (P<0.05). In the same puberty developmental stage, parameters in experimental groups were not different from those in control groups (P>0.05). Conclusion Expressions of KISS-I and GPRS4 genes are associated with developmental stages of puberty, indicating that KISS-1 and GPR54 genes may play important roles in onset and development of true precocious puberty.%目的 研究KISS-1和GPR54基因在雌性性早熟大鼠下丘脑中的表达,探讨其在性早熟发生中的作用.方法 将雌性26日龄SD大鼠50只随机分为实验1组、实验2组、对照1组、对照2组、对照3组.实验组皮下注射N-甲基-D,L-天冬氨酸(NMA)每天2次直至阴道开放,对照组注射生理盐水,观察大鼠阴道开放时间及性周期,测量子宫指数、卵巢指教、卵巢黄体出现率、子宫壁厚度

  3. A special evaluation: The ARCAL programme

    International Nuclear Information System (INIS)

    The Regional Co-operative Arrangements for the Promotion of Nuclear Science and Technology in Latin America, ARCAL, came into being in 1983. At a meeting held in Vienna in September 1984, ten Latin American countries agreed to participate in the programme, the Guidelines setting up the structure of the programme were approved and nine areas of development were identified to initiate project activities. The programme, which is now in its second phase and in its ninth year of implementation, has 17 Member States and includes fifteen projects. Total disbursements under the ARCAL programme during the period 1983 - 1991 amounted to $8.5 million, including $5.4 million from the Technical Assistance and Co-operation Fund (TACF), $2.2 million from extrabudgetary sources, and some $0.9 million in the form of in-kind contributions. As of September 1992, equipment totaling $3.5 million, 385 man-months of expert services, and 108 fellowships for approximately 150 man-months of training had been provided to ARCAL Member States within the context of fifteen ARCAL projects. In addition, 1844 Latin Americans were trained in 194 ARCAL training courses. The evaluation concluded that, as a result of the ARCAL programme, there is now better knowledge in participating countries about nuclear techniques and technology, as well as greater awareness at most levels of the importance of radiological safety and of the need to implement radiation protection measures, both a the national and at the regional level. The programme has contributed to developing and/or improving capabilities in the region in various applications of nuclear techniques through training activities. The programme has further allowed the establishment of regional collaborative links, particularly between countries with similar interests, in important fields of application, such as agriculture and nuclear medicine. Figs and tabs

  4. Elemental activation analysis with decay and prompt gamma ray techniques, using isotopic neutron sources and a nuclear research reactor. Part of a coordinated programme on nuclear-based techniques in geology and mineral prospecting

    International Nuclear Information System (INIS)

    This is to review the research activities carried out through the IAEA research Project 1697/RB ''Elemental activation analysis with decay and prompt gamma ray techniques, using isotopic neutron sources and the nuclear research reactor. The programme of work includes: a) Development of decay and prompt gamma ray activation techniques for mineral exploration. b) Development of epithermal NAA in addition to thermal NAA especially for gold ore. c) Development of non-destructive insitu elemental analysis with decay and prompt gamma ray techniques using isotopic neutron sources. A joint programme has been established with the Egyptian Geological Surrey and Mining Authority for using nuclear techniques in evaluating gold prospects of several ancient gold mines and investigating several tin-tantalum deposits, which were discovered over the last few years. Two sources of neutrons were used for irradiation, one of the dry channels of the two megawatts research reactor, ET-RR-1 for laboratory studies, and a Pu-Be neutron source in paraffin assembly for possible insitu work

  5. Planning environmental sanitation programmes in emergencies.

    Science.gov (United States)

    Harvey, Peter A; Reed, Robert A

    2005-06-01

    Environmental sanitation programmes are vital for tackling environmental-related disease and ensuring human dignity in emergency situations. If they are to have maximum impact they must be planned in a rapid but systematic manner. An appropriate planning process comprises five key stages: rapid assessment and priority setting; outline programme design; immediate action; detailed programme design; and implementation. The assessment should be based on carefully selected data, which are analysed via comparison with suitable minimum objectives. How the intervention should be prioritised is determined through objective ranking of different environmental sanitation sector needs. Next, a programme design outline is produced to identify immediate and longer-term intervention activities and to guarantee that apposite resources are made available. Immediate action is taken to meet acute emergency needs while the detailed programme design takes shape. This entails in-depth consultation with the affected community and comprehensive planning of activities and resource requirements. Implementation can then begin, which should involve pertinent management and monitoring strategies. PMID:15910646

  6. Expression of RFamide-Related Peptide-3 (RFRP-3) mRNA in Dorsomedial Hypothalamic Nucleus and KiSS-1 mRNA in Arcuate Nucleus of Rat during Pregnancy

    Science.gov (United States)

    Sabet Sarvestani, Fatemeh; Tamadon, Amin; Koohi-Hosseinabadi, Omid; Mohammadi Nezhad, Saeed; Rahmanifar, Farhad; Jafarzadeh Shirazi, Mohammad Reza; Tanideh, Nader; Moghadam, Ali; Niazi, Ali

    2014-01-01

    Background RFamide-related peptide-3 (RFRP-3) and kisspeptin (KiSS-1) are known to respectively inhibit and stimulate gonadotropin releasing hormone (GnRH) and lute- inizing hormone (LH) secretion in rat. The aim of the present study was to evaluate the relative mRNA expression of RFRP-3 and KiSS-1 in the hypothalamus of pregnant rats. Materials and Methods In a randomized controlled experimental study, the exact preg- nancy day of 18 Sprague-Dawley rats were confirmed using the vaginal smear method and were equally assigned to three groups of days 7, 14 and 21 of pregnancy. Four non- pregnant female rats were ovariectomized and assigned as the control group. All rats were decapitated, and the dorsomedial hypothalamic nucleus (DMH) and the arcuate nucleus (ARC) for detection of KiSS-1 mRNA were separated from their hypothalamus to detect RFRP-3 and KiSS-1 mRNA respectively. Then, their relative expressions were compared between control and pregnant groups using real-time polymerase chain reac- tion (PCR). Results The relative expression of RFRP-3 mRNA in DMH did not change significantly during pregnancy (p>0.01). However, the relative expression of KiSS-1 mRNA in ARC was at its highest in day 7 of pregnancy and decreased until day 21 of pregnancy (p<0.01). Conclusion Decrease in GnRH and LH secretion during the pregnancy of rat may be controlled by constant expression of RFRP-3 mRNA and reduced expression of KiSS-1 mRNA in hypothalamus. PMID:25379163

  7. Expression of RFamide-Related Peptide-3 (RFRP-3 mRNA in Dorsomedial Hypothalamic Nucleus and KiSS-1 mRNA in Arcuate Nucleus of Rat during Pregnancy

    Directory of Open Access Journals (Sweden)

    Fatemeh Sabet Sarvestani

    2014-11-01

    Full Text Available Background: RFamide-related peptide-3 (RFRP-3 and kisspeptin (KiSS-1 are known to respectively inhibit and stimulate gonadotropin releasing hormone (GnRH and luteinizing hormone (LH secretion in rat. The aim of the present study was to evaluate the relative mRNA expression of RFRP-3 and KiSS-1 in the hypothalamus of pregnant rats. Materials and Methods: In a randomized controlled experimental study, the exact pregnancy day of 18 Sprague-Dawley rats were confirmed using the vaginal smear method and were equally assigned to three groups of days 7, 14 and 21 of pregnancy. Four nonpregnant female rats were ovariectomized and assigned as the control group. All rats were decapitated, and the dorsomedial hypothalamic nucleus (DMH and the arcuate nucleus (ARC for detection of KiSS-1 mRNA were separated from their hypothalamus to detect RFRP-3 and KiSS-1 mRNA respectively. Then, their relative expressions were compared between control and pregnant groups using real-time polymerase chain reaction (PCR. Results: The relative expression of RFRP-3 mRNA in DMH did not change significantly during pregnancy (p>0.01. However, the relative expression of KiSS-1 mRNA in ARC was at its highest in day 7 of pregnancy and decreased until day 21 of pregnancy (p<0.01. Conclusion: Decrease in GnRH and LH secretion during the pregnancy of rat may be controlled by constant expression of RFRP-3 mRNA and reduced expression of KiSS-1 mRNA in hypothalamus.

  8. Effect of Final Kissing Balloon Dilatation after One-stent Technique at Left-main Bifurcation: A Single Center Data

    Institute of Scientific and Technical Information of China (English)

    Zhan Gao; Bo Xu; Yue-Jin Yang; Shu-Bin Qiao; Yong-Jian Wu; Tao Chen; Liang Xu

    2015-01-01

    Background:Whether final kissing balloon (FKB) dilatation after one-stent implantation at left-main (LM) bifurcation site remains unclear.Therefore,this large sample and long-term follow-up study comparatively assessed the impact of FKB in patients with unprotected LM disease treated with one-stent strategy.Methods:Total 1528 consecutive patients underwent LM percutaneous coronary intervention in one center from January 2004 to December 2010 were enrolled; among them,790 patients treated with one drug-eluting stent crossover LM to left anterior descending (LAD) with FKB (n =230) or no FKB (n =560) were comparatively analyzed.Primary outcome was the rate of major adverse cardiovascular events,defined as a composite of death,myocardial infarction (MI) and target vessel revascularization (TVR).Results:Overall,The prevalence of true bifurcation lesions,which included Medina classification (1,1,1),(1,0,1),or (0,1,1),was similar between-groups (non-FKB:37.0% vs.FKB:39.6%,P =0.49).At mean 4 years follow-up,rates of major adverse cardiovascular events (non-FKB:10.0% vs.FKB:7.8%,P =0.33),death,MI and TVR were not significantly different between-groups.In multivariate propensity-matched regression analysis,FKB was not an independent predictor of adverse outcomes.Conclusions:For patients treated with one-stent crossover LM to LAD,clinical outcomes appear similar between FKB and non-FKB strategy.

  9. Donor transplant programme

    International Nuclear Information System (INIS)

    The transplantation of organs and tissues from one human to another human has become an essential and well established form of therapy for many types of organ and tissue failure. In Malaysia, kidney, cornea and bone marrow transplantation are well established. Recently, liver, bone and heart transplanation have been performed. Unfortunately, because of the lack of cadaveric organ donation, only a limited number of solid organ transplantation have been performed. The cadaveric organ donor rate in Malaysia is low at less than one per million population. The first tissue transplanted in Malaysia was the cornea which was performed in the early 1970s. At that time and even now the majority of corneas came from Sri Lanka. The first kidney transplant was performed in 1975 from a live related donor. The majority of the 629 kidney transplants done at Hospital Kuala Lumpur to date have been from live related donors. Only 35 were from cadaver donors. Similarly, the liver transplantation programme which started in 1995 are from live related donors. A more concerted effort has been made recently to increase the awareness of the public and the health professionals on organ and tissue donation. This national effort to promote organ and tissue donation seems to have gathered momentum in 1997 with the first heart transplant successfully performed at the National Heart Institute. The rate of cadaveric donors has also increased from a previous average of I to 2 per year to 6 per year in the last one year. These developments are most encouraging and may signal the coming of age of our transplantati on programme. The Ministry of Health in conjunction with various institutions, organizations and professional groups, have taken a number of proactive measures to facilitate the development of the cadaveric organ donation programme. Efforts to increase public awareness and to overcome the negative cultural attitude towards organ donation have been intensified. Equally important are efforts

  10. Position of the kissing-loop interaction associated with PTE-type 3’CITEs can affect enhancement of cap-independent translation

    OpenAIRE

    Chattopadhyay, Maitreyi; Kuhlmann, Micki M.; Kumar, Kalyani; Simon, Anne E.

    2014-01-01

    The Panicum mosaic virus-like translation enhancer (PTE) functions as a cap-independent translation enhancer (3’CITE) in members of several Tombusviridae genera including 7/19 carmoviruses. For nearly all PTE, a kissing-loop connects the element with a hairpin found in several conserved locations in the genomic RNA (5’ terminal hairpin or ~100 nt from the 5’end) and small subgenomic RNA (~63 nt from the 5’end). Moving the interaction closer to the 5’end in reporter mRNAs using Saguaro cactus ...

  11. Hacia un análisis comparativo de Cromañón, Ycuá Bolaños y Kiss

    OpenAIRE

    Laura Codaro

    2015-01-01

    Cromañón en Argentina, Ycuá Bolaños en Paraguay y Kiss en Brasil, representaron tres grandes tragedias desarrolladas en lo que va del siglo XXI que causaron la muerte de centenares de personas. Estos incendios devenidos “hechos de carácter criminal” mostraron, en principio, la precariedad en la que se encontraban numerosos espacios a los que muchos jóvenes concurrían para divertirse, escuchar un show musical o simplemente comprar algún producto. La desregulación estatal en las habilitaciones ...

  12. The INTEGRAL Core Observing Programme

    DEFF Research Database (Denmark)

    Winkler, C.; Gehrels, N.; Lund, Niels;

    1999-01-01

    The Core Programme of the INTEGRAL mission is defined as the portion of the scientific programme covering the guaranteed time observations for the INTEGRAL Science Working Team. This paper describes the current status of the Core Programme preparations and summarizes the key elements...

  13. Fusion technology programme

    International Nuclear Information System (INIS)

    The KfK-Association has continued work on 17 R and D contracts of the Fusion Technology Programme. An effort of 94 manyears per year is at present contributed by 10 KfK departments, covering all aereas defined in the Fusion Technology Programme. The dominant part of the work is directed towards the need of the NET design or supporting experiments. Some additional effort addresses long term technological issues and system studies relevant to DEMO or confinement schemes alternative to tokamaks. Direct contribution to the NET team has increased by augmentation of NET study contracts and delegation of personnel, three KfK delegates being at present members of the NET team. In reverse, specifications and design guidelines worked out by NET have started to have an impact on the current R and D-work in the laboratory. (orig./GG)

  14. Pharmacovigilance programme of India

    Directory of Open Access Journals (Sweden)

    Kalaiselvan Vivekanandan

    2012-01-01

    Full Text Available The monitoring and reporting of adverse drug reactions (ADRs through pharmacovigilance is vital to patient safety and rational prescribing. In India, Central Drugs Standard Control Organization (CDSCO initiated Pharmacovigilance Programme of India (PvPI to report ADRs through ADRs monitoring centres in India. Indian Pharmacopoeia Commission (IPC is functioning as National Coordination Centre (NCC for PvPI. The ADRs are reported to NCC through VigiFlow by various centres are evaluated and committed to Uppsala Monitoring Centre, Sweden. The potential benefit of the PvPI is aimed to reducing or eliminating a harm of medicine. Continuous efforts of the healthcare professionals and the patients are expected to make this as one of the most successful and effective programmes. The present article updates the status and future plan of PvPI.

  15. The Mathematica programmer

    CERN Document Server

    Maeder, Roman E

    1994-01-01

    The Mathematica Programmer covers the fundamental programming paradigms and applications of programming languages. This book is organized into two parts encompassing 10 chapters. Part 1 begins with an overview of the programming paradigms. This part also treats abstract data types, polymorphism and message passing, object-oriented programming, and relational databases. Part 2 looks into the practical aspects of programming languages, including in lists and power series, fractal curves, and minimal surfaces.This book will prove useful to mathematicians and computer scientists.

  16. Programmable mechanical metamaterials.

    Science.gov (United States)

    Florijn, Bastiaan; Coulais, Corentin; van Hecke, Martin

    2014-10-24

    We create mechanical metamaterials whose response to uniaxial compression can be programmed by lateral confinement, allowing monotonic, nonmonotonic, and hysteretic behavior. These functionalities arise from a broken rotational symmetry which causes highly nonlinear coupling of deformations along the two primary axes of these metamaterials. We introduce a soft mechanism model which captures the programmable mechanics, and outline a general design strategy for confined mechanical metamaterials. Finally, we show how inhomogeneous confinement can be explored to create multistability and giant hysteresis.

  17. Programmable Quantitative DNA Nanothermometers.

    Science.gov (United States)

    Gareau, David; Desrosiers, Arnaud; Vallée-Bélisle, Alexis

    2016-07-13

    Developing molecules, switches, probes or nanomaterials that are able to respond to specific temperature changes should prove of utility for several applications in nanotechnology. Here, we describe bioinspired strategies to design DNA thermoswitches with programmable linear response ranges that can provide either a precise ultrasensitive response over a desired, small temperature interval (±0.05 °C) or an extended linear response over a wide temperature range (e.g., from 25 to 90 °C). Using structural modifications or inexpensive DNA stabilizers, we show that we can tune the transition midpoints of DNA thermometers from 30 to 85 °C. Using multimeric switch architectures, we are able to create ultrasensitive thermometers that display large quantitative fluorescence gains within small temperature variation (e.g., > 700% over 10 °C). Using a combination of thermoswitches of different stabilities or a mix of stabilizers of various strengths, we can create extended thermometers that respond linearly up to 50 °C in temperature range. Here, we demonstrate the reversibility, robustness, and efficiency of these programmable DNA thermometers by monitoring temperature change inside individual wells during polymerase chain reactions. We discuss the potential applications of these programmable DNA thermoswitches in various nanotechnology fields including cell imaging, nanofluidics, nanomedecine, nanoelectronics, nanomaterial, and synthetic biology. PMID:27058370

  18. A new video programme

    CERN Multimedia

    CERN video productions

    2011-01-01

    "What's new @ CERN?", a new monthly video programme, will be broadcast on the Monday of every month on webcast.cern.ch. Aimed at the general public, the programme will cover the latest CERN news, with guests and explanatory features. Tune in on Monday 3 October at 4 pm (CET) to see the programme in English, and then at 4:20 pm (CET) for the French version.   var flash_video_player=get_video_player_path(); insert_player_for_external('Video/Public/Movies/2011/CERN-MOVIE-2011-129/CERN-MOVIE-2011-129-0753-kbps-640x360-25-fps-audio-64-kbps-44-kHz-stereo', 'mms://mediastream.cern.ch/MediaArchive/Video/Public/Movies/2011/CERN-MOVIE-2011-129/CERN-MOVIE-2011-129-Multirate-200-to-753-kbps-640x360-25-fps.wmv', 'false', 480, 360, 'https://mediastream.cern.ch/MediaArchive/Video/Public/Movies/2011/CERN-MOVIE-2011-129/CERN-MOVIE-2011-129-posterframe-640x360-at-10-percent.jpg', '1383406', true, 'Video/Public/Movies/2011/CERN-MOVIE-2011-129/CERN-MOVIE-2011-129-0600-kbps-maxH-360-25-fps-...

  19. Economic viability of new launched school lunch programmes

    DEFF Research Database (Denmark)

    Jensen, Jørgen Dejgård; Smed, Sinne; Mørkbak, Morten Raun;

    2013-01-01

    activities related to the schools’ support and the users’ feeling of ownership, as well as internal professionalism and leadership in the implementation of the school lunch programme are important for the viability of the programme. Strong performance on the latter factors might to some extent compensate...

  20. Key United States programmes for the security of radioactive sources

    International Nuclear Information System (INIS)

    The paper discusses key US programme activities related to the security of radioactive sources, including both domestic and international programmes; the US Department of Energy-Nuclear Regulatory Commission joint report and findings; and critical partnerships for future efforts to preclude terrorist attacks using radioactive sources. (author)

  1. The Difference of Kiss1 and GPR54 Gene Expressions in Hypothalamus-Pituitary-Ovary Axis of Meishan and LY Breed Gilts%梅山与长大母猪下丘脑-垂体-卵巢轴Kiss1和GPR54基因的表达差异

    Institute of Scientific and Technical Information of China (English)

    朱碧泉; 李卓昭; 吴德; 方正锋; 林燕; 车炼强

    2011-01-01

    研究早熟与晚熟品种母猪下丘脑-垂体-卵巢轴Kiss 1,和GPR54基因的表达差异.选用8头梅山母猪与12头长大(LY)母猪为研究对象,梅山母猪于70d和100 d屠宰,LY母猪于70、100 d和199 d屠宰,收集血清及下丘脑、垂体、卵巢组织样品.ELISA检测血清瘦素(Leptin)和雌二醇(E2)水平,PCR克隆梅山与LY母猪Kiss 1基因编码序列,实时荧光定量PCR检测母猪下丘脑、垂体、卵巢组织Kiss 1和GPR54基因表达水平.结果表明:梅山与LY母猪Kiss 1基因编码序列相似性为100%;梅山与LY母猪初情期下丘脑Kiss 1基因表达量极显著高于垂体与卵巢(P 0.05). The concentration of serum Leptin in MS gilts was significantly higher than that at LY gilts at the same age(P <0.01), while E2 levels was significantly higher than that of LY gilts at 100 d and puberty (P <0.01). Serum leptin was significantly positively correlated to the expressions of Kissl and GPR54 gene in hypothalamus at puberty (P <0.05) , but E2 was significantly positively correlated with Kissl gene expression in hypothalamic only (P <0.01), In conclusion, the coding sequences of Kissl gene in MS and LY gilts have a similarity of 100% . MS gilts show early puberty onsets age than LY gilts, which were probably determined by a higher Kissl gene expression in hypothalamus-pituitary -ovary axis, while hypothalamic Kissl expression were closely positively related to serum Leptin and E2 concentrations.

  2. Costs of Loyalty Programmes Implementation in Pharmacies

    Directory of Open Access Journals (Sweden)

    Maria Sierpińska

    2010-10-01

    Full Text Available Receiving the customer is in today’s market realities top marketing companies. The build a sustainable partnership relation between the seller and the buyer is decide on businesses, takings and profit potential. Increasingly, therefore, perpetuates the view that create lasting relationships is an essential factor in improving the effectiveness of marketing activities conducted by modern businesses. The paper presents the implementation costs of loyalty programmes in pharmacies. These costs are presented based on a study of one of the largest pharmacy loyalty programmes in Poland: “I care for health”.

  3. Quality control programme for radiotherapy

    International Nuclear Information System (INIS)

    A 3 years pilot programme started in January 2000 with 33 philanthropic cancer institutions that provides medical services to 60% of the patients from the national social security system. Brazil has today 161 radiotherapy services (144 operating with megavoltage equipment). These 33 institutions are distributed over 19 Brazilian states. The aim of this programme is: To create conditions to allow the participants to apply the radiotherapy with quality and efficacy; To promote up dating courses for the physicians, physicists and technicians of these 33 Institutions. With the following objectives: To recommend dosimetric and radiological protection procedures in order to guarantee the tumor prescribed dose and safe working conditions; To help in establishing and implementing these procedures. The main activities are: local quality control evaluations, postal TLD audits in reference conditions, postal TLD audits in off axis conditions and training. The local quality control program has already evaluated 22 institutions with 43 machines (25 Co-60 and 18 linear accelerators). In these visits we perform dosimetric, electrical, mechanical and safety tests. As foreseen, we found more problems among the old Co-60 machines i.e., field flatness, size, symmetry and relative output factors; lasers positioning system alignment; optical distance indicator; radiation and light field coincidence; optical and mechanical distance indicators agreement, than among the linear accelerators i.e., field flatness and size; lasers positioning system alignment; tray interlocking and wedge filter factors

  4. 2001 - 2002 ACADEMIC TRAINING PROGRAMME

    CERN Multimedia

    Academic Training; Tel. 73127

    2001-01-01

    1ST TERM 1ST OCTOBER - 23 NOVEMBER 2001 LECTURE SERIES FOR POSTGRADUATE STUDENTS The Autumn term of the Academic Training Programme is about to start. As usual, the first term includes lectures primarily dedicated to Post-graduate students. These are meant to help students complement the courses available from their home Universities with lectures on topics close to CERN activities. The lectures are nevertheless open to all CERN staff, and in particular to young Fellows. This year's series include courses on Accelerator Physics, on Field Theory, and on Symmetry Breaking Phenomena in Physics. The course on Accelerators by Dr. Wilson has been a regular feature on the Academic Training programme for many previous editions. This year, the course will be updated to include new sections on Colliders and on future facilities such as the Neutrino Factory. A good introduction to this very successful course can be found in the previous version of these lectures, available from the Web Lecture Archive Project: http://w...

  5. Sellafield Decommissioning Programme - Update and Lessons Learned

    Energy Technology Data Exchange (ETDEWEB)

    Lutwyche, P. R.; Challinor, S. F.

    2003-02-24

    The Sellafield site in North West England has over 240 active facilities covering the full nuclear cycle from fuel manufacture through generation, reprocessing and waste treatment. The Sellafield decommissioning programme was formally initiated in the mid 1980s though several plants had been decommissioned prior to this primarily to create space for other plants. Since the initiation of the programme 7 plants have been completely decommissioned, significant progress has been made in a further 16 and a total of 56 major project phases have been completed. This programme update will explain the decommissioning arrangements and strategies and illustrate the progress made on a number of the plants including the Windscale Pile Chimneys, the first reprocessing plan and plutonium plants. These present a range of different challenges and requiring approaches from fully hands on to fully remote. Some of the key lessons learned will be highlighted.

  6. Aminoglycoside binding to the HIV-1 RNA dimerization initiation site: thermodynamics and effect on the kissing-loop to duplex conversion.

    Science.gov (United States)

    Bernacchi, Serena; Freisz, Séverine; Maechling, Clarisse; Spiess, Bernard; Marquet, Roland; Dumas, Philippe; Ennifar, Eric

    2007-01-01

    Owing to a striking, and most likely fortuitous, structural and sequence similarity with the bacterial 16 S ribosomal A site, the RNA kissing-loop complex formed by the HIV-1 genomic RNA dimerization initiation site (DIS) specifically binds 4,5-disubstituted 2-deoxystreptamine (2-DOS) aminoglycoside antibiotics. We used chemical probing, molecular modeling, isothermal titration calorimetry (ITC) and UV melting to investigate aminoglycoside binding to the DIS loop-loop complex. We showed that apramycin, an aminoglycoside containing a bicyclic moiety, also binds the DIS, but in a different way than 4,5-disubstituted 2-DOS aminoglycosides. The determination of thermodynamic parameters for various aminoglycosides revealed the role of the different rings in the drug-RNA interaction. Surprisingly, we found that the affinity of lividomycin and neomycin for the DIS (K(d) approximately 30 nM) is significantly higher than that obtained in the same experimental conditions for their natural target, the bacterial A site (K(d) approximately 1.6 microM). In good agreement with their respective affinity, aminoglycoside increase the melting temperature of the loop-loop interaction and also block the conversion from kissing-loop complex to extended duplex. Taken together, our data might be useful for selecting new molecules with improved specificity and affinity toward the HIV-1 DIS RNA. PMID:17942426

  7. Natural variation in rosette size under salt stress conditions corresponds to developmental differences between Arabidopsis accessions and allelic variation in the LRR-KISS gene

    KAUST Repository

    Julkowska, Magdalena M.

    2016-02-11

    Natural variation among Arabidopsis accessions is an important genetic resource to identify mechanisms underlying plant development and stress tolerance. To evaluate the natural variation in salinity stress tolerance, two large-scale experiments were performed on two populations consisting of 160 Arabidopsis accessions each. Multiple traits, including projected rosette area, and fresh and dry weight were collected as an estimate for salinity tolerance. Our results reveal a correlation between rosette size under salt stress conditions and developmental differences between the accessions grown in control conditions, suggesting that in general larger plants were more salt tolerant. This correlation was less pronounced when plants were grown under severe salt stress conditions. Subsequent genome wide association study (GWAS) revealed associations with novel candidate genes for salinity tolerance such as LRR-KISS (At4g08850), flowering locus KH-domain containing protein and a DUF1639-containing protein. Accessions with high LRR-KISS expression developed larger rosettes under salt stress conditions. Further characterization of allelic variation in candidate genes identified in this study will provide more insight into mechanisms of salt stress tolerance due to enhanced shoot growth.

  8. FFUSION research programme 1993-1998. Final report of the Finnish fusion research programme

    Energy Technology Data Exchange (ETDEWEB)

    Karttunen, S.; Heikkinen, J.; Korhonen, R. [VTT Energy, Espoo (Finland)] [and others

    1998-12-31

    This report summarizes the results of the Fusion Energy Research Programme, FFUSION, during the period 1993-1998. After the planning phase the programme started in 1994, and later in March 1995 the FFUSION Programme was integrated into the EU Fusion Programme and the Association Euratom-Tekes was established. Research areas in the FFUSION Programme are (1) fusion physics and plasma engineering, (2) fusion reactor materials and (3) remote handling systems. In all research areas industry is involved. Recently, a project on environmental aspects of fusion and other future energy systems started as a part of the socio-economic research (SERF) in the Euratom Fusion Programme. A crucial component of the FFUSION programme is the close collaboration between VTT Research Institutes, universities and Finnish industry. This collaboration has guaranteed dynamic and versatile research teams, which are large enough to tackle challenging research and development projects. Regarding industrial fusion R and D activities, the major step was the membership of Imatran Voima Oy in the EFET Consortium (European Fusion Engineering and Technology), which further strengthened the position of industry in the engineering design activities of ITER. The number of FFUSION research projects was 66. In addition, there were 32 industrial R and D projects. The total cost of the FFUSION Programme in 1993-1998 amounted to FIM 54 million in research at VTT and universities and an additional FIM 21 million for R and D in Finnish industry. The main part of the funding was provided by Tekes, 36%. Since 1995, yearly Euratom funding has exceeded 25%. The FFUSION research teams have played an active role in the European Programme, receiving excellent recognition from the European partners. Theoretical and computational fusion physics has been at a high scientific level and the group collaborates with the leading experimental laboratories in Europe. Fusion technology is focused on reactor materials, joining

  9. FFUSION research programme 1993-1998. Final report of the Finnish fusion research programme

    International Nuclear Information System (INIS)

    This report summarizes the results of the Fusion Energy Research Programme, FFUSION, during the period 1993-1998. After the planning phase the programme started in 1994, and later in March 1995 the FFUSION Programme was integrated into the EU Fusion Programme and the Association Euratom-Tekes was established. Research areas in the FFUSION Programme are (1) fusion physics and plasma engineering, (2) fusion reactor materials and (3) remote handling systems. In all research areas industry is involved. Recently, a project on environmental aspects of fusion and other future energy systems started as a part of the socio-economic research (SERF) in the Euratom Fusion Programme. A crucial component of the FFUSION programme is the close collaboration between VTT Research Institutes, universities and Finnish industry. This collaboration has guaranteed dynamic and versatile research teams, which are large enough to tackle challenging research and development projects. Regarding industrial fusion R and D activities, the major step was the membership of Imatran Voima Oy in the EFET Consortium (European Fusion Engineering and Technology), which further strengthened the position of industry in the engineering design activities of ITER. The number of FFUSION research projects was 66. In addition, there were 32 industrial R and D projects. The total cost of the FFUSION Programme in 1993-1998 amounted to FIM 54 million in research at VTT and universities and an additional FIM 21 million for R and D in Finnish industry. The main part of the funding was provided by Tekes, 36%. Since 1995, yearly Euratom funding has exceeded 25%. The FFUSION research teams have played an active role in the European Programme, receiving excellent recognition from the European partners. Theoretical and computational fusion physics has been at a high scientific level and the group collaborates with the leading experimental laboratories in Europe. Fusion technology is focused on reactor materials, joining

  10. Finnish Research Programme on Nuclear Waste Management (KYT). Framework Programme for 2002-2005

    International Nuclear Information System (INIS)

    The new Finnish research programme on nuclear waste management (KYT) will be conducted in 2002 - 2005. This framework programme describes the starting point, the basic aims and the organisation of the research programme. The starting point of the KYT programme is derived from the present state and future challenges of Finnish nuclear waste management. The research programme is funded mainly by the Ministry of Trade and Industry (KTM), the Radiation and Nuclear Safety Authority (STUK), Posiva Oy, Fortum Oyj, Teollisuuden Voima Oy (TVO), and the National Technology Agency (Tekes). As both regulators and implementors are involved, the research programme concentrates on neutral research topics that must be studied in any case. Methods and tools for experimental and theoretical studies fall in this category. State of the art -reviews on relevant topics also create national know-how. Topics that directly belong to licensing activities of nuclear waste management are excluded from the research programme. KYT carries out technical studies that increase national know-how in the area of nuclear waste management. The aim is to maintain and develop basic expertise needed in the operations derived from the national nuclear waste management plan. The studies have been divided into strategic studies and studies enhancing the long-term safety of spent nuclear fuel disposal. Strategic studies support the overall feasibility of Finnish nuclear waste management. These studies include basic options and overall safety principles related to nuclear fuel cycle and nuclear waste management. In addition, general cost estimates as well as general safety considerations related to transportations, low- and medium level wastes, and decommissioning are included in strategic studies. Studies supporting the long-term safety of spent fuel disposal include issues related to performance assessment methodology, release of radionuclides from the repository, behaviour of bedrock and groundwater

  11. Binary mask programmable hologram.

    Science.gov (United States)

    Tsang, P W M; Poon, T-C; Zhou, Changhe; Cheung, K W K

    2012-11-19

    We report, for the first time, the concept and generation of a novel Fresnel hologram called the digital binary mask programmable hologram (BMPH). A BMPH is comprised of a static, high resolution binary grating that is overlaid with a lower resolution binary mask. The reconstructed image of the BMPH can be programmed to approximate a target image (including both intensity and depth information) by configuring the pattern of the binary mask with a simple genetic algorithm (SGA). As the low resolution binary mask can be realized with less stringent display technology, our method enables the development of simple and economical holographic video display.

  12. Flexible programmable logic module

    Energy Technology Data Exchange (ETDEWEB)

    Robertson, Perry J. (Albuquerque, NM); Hutchinson, Robert L. (Albuquerque, NM); Pierson, Lyndon G. (Albuquerque, NM)

    2001-01-01

    The circuit module of this invention is a VME board containing a plurality of programmable logic devices (PLDs), a controlled impedance clock tree, and interconnecting buses. The PLDs are arranged to permit systolic processing of a problem by offering wide data buses and a plurality of processing nodes. The board contains a clock reference and clock distribution tree that can drive each of the PLDs with two critically timed clock references. External clock references can be used to drive additional circuit modules all operating from the same synchronous clock reference.

  13. Programmable ferroelectric tunnel memristor

    OpenAIRE

    Andy eQuindeau; Dietrich eHesse; Marin eAlexe

    2014-01-01

    We report an analogously programmable memristor based on genuine electronic resistive switching combining ferroelectric switching and electron tunneling. The tunnel current through an 8 unit cell thick epitaxial Pb(Zr[0.2]Ti[0.8])O[3] film sandwiched between La[0.7]Sr[0.3]MnO[3] and cobalt electrodes obeys the Kolmogorov-Avrami-Ishibashi model for bidimensional growth with a characteristic switching time in the order of 10^-7 seconds. The analytical description of switching kinetics allows us...

  14. Programme Biology - Health protection

    International Nuclear Information System (INIS)

    The scientific results for 1975, of the five-year Biology-Health Protection programme adopted in 1971, are presented in two volumes. In volume one, Research in Radiation Protection are developed exclusively, including the following topics: measurement and interpretation of radiation (dosimetry); transfer of radioactive nuclides in the constituents of the environment; hereditary effects of radiation; short-term effects (acute irradiation syndrome and its treatment); long-term effects and toxicology of radioactive elements. In volume, two Research on applications in Agriculture and Medicine are developed. It includes: mutagenesis; soil-plant relations; radiation analysis; food conservation; cell culture; radioentomology. Research on applications in Medicine include: Nuclear Medicine and Neutron Dosimetry

  15. CASINDO Programme Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    Van der Linden, N.; Smekens, K.; Bole-Rentel, T.; Saidi, R. [Unit ECN Policy Studies, Energy research Centre of the Netherlands ECN, Petten (Netherlands); Wijnker, M. [Eindhoven University of Technology TUE, Eindhoven (Netherlands); Kamphuis, E. [ETC Netherlands, Leusden (Netherlands); Winarno, Oetomo Tri [Institute of Technology, Bandung (Indonesia); Permana, Iman [Technical Education Development Centre, Bandung (Indonesia)

    2012-06-15

    The overall objective of the CASINDO programme is to establish a self-sustaining and self-developing structure at both the national and regional level to build and strengthen human capacity to enable the provinces of North Sumatra, Yogyakarta, Central Java, West Nusa Tenggara and Papua to formulate sound policies for renewable energy and energy efficiency and to develop and implement sustainable energy projects. CASINDO stands for Capacity development and strenghtening for energy policy formulation adn implementation of sustainable energy projects in Indonesia.

  16. Accident prevention programme

    International Nuclear Information System (INIS)

    This study by the Steel Industry Safety and Health Commission was made within the context of the application by undertakings of the principles of accident and disease prevention previously adopted by the said Commission. It puts forward recommendations for the effective and gradual implementation of a programme of action on occupational health and safety in the various departments of an undertaking and in the undertaking as a whole. The methods proposed in this study are likely to be of interest to all undertakings in the metallurgical industry and other industrial sectors

  17. Progress in Programmable Logic

    Directory of Open Access Journals (Sweden)

    Jozef Cuntala

    2004-01-01

    Full Text Available Programmable logic devices (PLD are situated on important place among microelectronic components thanks to the continuing technological development of semiconductor components, due to new architectures and new approaches to digital systems design. Software design of various complicated digital systems becomes advantageous article of many firms. The Department of Electronics and Electrotechnology pays pemanent attention to mentioned components in application field. The collective of authors wants in this article point out on possibilities of design of digital system using the PLD. The paper plan contains the following basic parts: Technological aspects that influence development of configurable logic devices, Methodology od design and implementation and Flexibility of PLD interface.

  18. A programmable Fortran preprocessor

    Energy Technology Data Exchange (ETDEWEB)

    Rosing, M.

    1995-06-01

    A programmable Fortran preprocessor is described. It allows users to define compile time operations that can examine and modify the source tree before it is compiled with a traditional compiler. This intermediate step allows the definition of routines and operations that adapt to the context in which they are used. Context sensitive operations increase the flexibility of abstractions that can be built without degrading efficiency, as compared to using traditional run time based abstractions such as libraries or objects. The preprocessor is described briefly along with an example of how it is used to add CMFortran array operations to Fortran77. Other preprocessors that have been implemented are also briefly described.

  19. X-chromosome kiss and tell: how the Xs go their separate ways.

    Science.gov (United States)

    Anguera, M C; Sun, B K; Xu, N; Lee, J T

    2006-01-01

    Loci associated with noncoding RNAs have important roles in X-chromosome inactivation (XCI), the dosage compensation mechanism by which one of two X chromosomes in female cells becomes transcriptionally silenced. The Xs start out as epigenetically equivalent chromosomes, but XCI requires a cell to treat two identical X chromosomes in completely different ways: One X chromosome must remain transcriptionally active while the other becomes repressed. In the embryo of eutherian mammals, the choice to inactivate the maternal or paternal X chromosome is random. The fact that the Xs always adopt opposite fates hints at the existence of a trans-sensing mechanism to ensure the mutually exclusive silencing of one of the two Xs. This paper highlights recent evidence supporting a model for mutually exclusive choice that involves homologous chromosome pairing and the placement of asymmetric chromatin marks on the two Xs.

  20. Post-thaw viability of cryopreserved peripheral blood stem cells (PBSC) does not guarantee functional activity: important implications for quality assurance of stem cell transplant programmes.

    Science.gov (United States)

    Morgenstern, Daniel A; Ahsan, Gulrukh; Brocklesby, Margaret; Ings, Stuart; Balsa, Carmen; Veys, Paul; Brock, Penelope; Anderson, John; Amrolia, Persis; Goulden, Nicholas; Cale, Catherine M; Watts, Michael J

    2016-09-01

    Standard quality assurance (QA) of cryopreserved peripheral blood stem cells (PBSC) uses post-thaw viable CD34(+) cell counts. In 2013, concerns arose at Great Ormond Street Hospital (GOSH) about 8 patients with delayed engraftment following myeloablative chemotherapy with cryopreserved cell rescue, despite adequate post-thaw viable cell counts in all cases. Root cause analysis was undertaken; investigations suggested the freeze process itself was a contributing factor to suboptimal engraftment. Experiments were undertaken in which a single PBSC product was divided into three and cryopreserved in parallel using a control-rate freezer (CRF) or passive freezing method (-80°C freezer) at GOSH, or the same passive freezing at another laboratory. Viable CD34(+) counts were equivalent and adequate in each. Granulocyte-monocyte colony-forming unit assays demonstrated colonies from the products cryopreserved using passive freezing (both laboratories), but no colonies from products cryopreserved using the CRF. The CRF was shown to be operating within manufacturer's specifications with freeze-profile within acceptable limits. This experience has important implications for quality assurance for all transplant programmes, particularly those using cryopreserved products. The failure of post-thaw viable CD34(+) counts, the most widely used routine QA test available, to ensure PBSC function is of great concern and should prompt reassessment of protocols and QA procedures. PMID:27291859

  1. Perbandingan Gratification Sought Dan Gratification Obtained Pendengar Terhadap Program Stasiun Radio (Studi Komparatif tentang Motif dan Kepuasan Pendengar terhadap Program Stasiun Radio Kiss FM dan Prambors Medan di Kalangan Mahasiswa FISIP USU

    OpenAIRE

    Hutapea, Darma Lestari

    2011-01-01

    Penelitian ini bertujuan untuk membandingkan kepuasan ynag dicari (gratification sought) dan kepuasan yang diperoleh (gratification obtained) pendengar radio Kiss FM dan Prambors FM Medan dengan menggunakan perspektif Uses and Gratification. Model ini menekankan bahwa khalayak adalah pihak yang aktif terhadap penggunaan media. Khalayak bebas mengkonsumsi media yang disukainya. Sampel dalam penelitian ini adalah mahasiswa Fakultas Ilmu Sosial dan Ilmu Politik. Jumlah sampel y...

  2. Expression and Its Regulation of KiSS-1 Gene Related with Reproduction%KiSS-1基因与生殖相关的表达及其调节

    Institute of Scientific and Technical Information of China (English)

    王军; 孙蕾; 常喆

    2011-01-01

    Recently, it has been found that KiSS-1 gene plays important roles in mammalian reproduction. Kisspeptin, the peptide product of the KiSS-1 gene has been shown to be powerful stimulators of the gonadotropin. Recent advances of expression of KiSS-1 gene related with reproduction and its regulation of hypothalamic expression by sex steroid hormones, metabolic hormone and photoperiod were reviewed in this paper for providing a reference for the direction of further study of KiSS-1 gene.%最近研究发现,KiSS-1基因在哺乳动物生殖内分泌的调节中具有重要作用,其编码的产物——kisspeptin能够强有力地刺激促性腺激素的分泌.笔者综述了KiSS-1基因与生殖相关的表达及性腺类固醇激素、代谢激素与光周期对其在下丘脑表达调节的最新研究进展,为今后KiSS-1基因的研究取向提供参考.

  3. The expression and prognosis of tumor metastasis suppressor gene KISS-1 in the tissues of thyroid cancer%肿瘤转移抑制基因KISS-1在甲状腺癌组织中表达和预后的研究

    Institute of Scientific and Technical Information of China (English)

    姚宏; 魏正琍; 梁晓燕; 王虹; 平苏萍; 张庆升; 刘景

    2012-01-01

    Objective To detect the expressions of KISS-1 protein, MMP-2, MMP-9 and Ki-67 in thyroid cancer, and to explore the effects of these four proteins on occurrence and development of thyroid cancer. Methods Im-munohistochemical SP method was used to detect the expression of KISS-1 protein, MMP-2, MMP-9 and Ki-67 in 10 cases of normal thyroid tissue, 12 cases of nodular goiter, 13 cases of thyroid adenoma and 68 cases of thyroid carcinoma tissues. Thereafter, the significance of expressions of 4 proteins was analyzed in different clinical pathological characteristics and their correlations. Results In thyroid cancer group, the positive expression rate of KISS-1 protein (37%) was significantly lower than that in normal thyroid tissues, nodular goiter and thyroid adenoma groups (100%, 83%, 62%, P0.05). The positive rates of MMP-2 in thyroid cancer, nodular goiter and thyroid adenoma groups were respectively 78%, 54% and 67%, which were significantly higher than that in normal thyroid gland group (10% ,P0.05). The positive expression rates of MMP-9 in thyroid cancer, nodular goiter and thyroid adenoma groups were respectively 82%, 69% and 58%, which were obviously higher than that in normal thyroid gland group (20%, P0.05). The positive rate of Ki-67 in thyroid cancer group (88%) was significantly higher than that in normal thyroid gland, nodular goiter and thyroid adenoma groups (10%, 31%, 42%; P0.05). The expression of KISS-1 protein was negatively correlated with the expressions of MMP-2 and MMP-9 in thyroid cancer (r =-0.399, P<0.01). Conclusion The expressions of KISS-1 protein, MMP-2, MMP-9 and Ki-67 were correlated with the occurrence and development of thyroid cancer. The combined detection of the expression of these four proteins might be used as the important indicators in evaluating prognosis of thyroid cancer and guiding clinical target treatment.%目的 检测KISS-1蛋白、基质金属蛋白酶(MMP)-2、MMP-9及Ki67在甲状腺癌中的表达,探讨4者在

  4. Fast reactor programme

    International Nuclear Information System (INIS)

    This progress report summarizes the fast reactor research carried out by ECN during the period covering the year 1980. This research is mainly concerned with the cores of sodium-cooled breeders, in particular the SNR-300, and its related safety aspects. It comprises six items: A programme to determine relevant nuclear data of fission- and corrosion-products; A fuel performance programme comprising in-pile cladding failure experiments and a study of the consequences of loss-of-cooling and overpower; Basic research on fuel; Investigation of the changes in the mechanical properties of austenitic stainless steel DIN 1.4948 due to fast neutron doses, this material has been used in the manufacture of the reactor vessel and its internal components; Study of aerosols which could be formed at the time of a fast reactor accident and their progressive behaviour on leaking through cracks in the concrete containment; Studies on heat transfer in a sodium-cooled fast reactor core. As fast breeders operate at high power densities, an accurate knowledge of the heat transfer phenomena under single-phase and two-phase conditions is sought. (Auth.)

  5. PREPARATION FOR RETIREMENT PROGRAMME

    CERN Multimedia

    Human Resources Division

    2001-01-01

    27 March 2001 from 2.00 p.m. to 5.30 p.m. 28 March 2001 from 2.00 p.m. to 5.30 p.m. 29 March 2001 from 2.00 p.m. to 5.30 p.m. 30 March 2001 from 2.00 p.m. to 4.45 p.m. Auditorium (Main Building) After the success of the preparation seminars held in recent years, it has been decided that the programme should continue. The forthcoming seminar has been prepared in close collaboration with the CERN Pensioners' Association. The programme will be organised over several half-day sessions. Once again this year, a special session will be devoted to the 10th revision of the Swiss state pension scheme, the 'AVS' (Assurance-Vieillesse et Survivants), and the consequences for international civil servants. A talk will be given by Mrs Danièle Siebold, Director of the Caisse Cantonale Genevoise de Compensation, aimed mainly at those residing in or intending to move to Switzerland, or who worked in Switzerland before joining CERN. To enable Mrs Siebold to respond to your concerns as effectively as possible, please ...

  6. Accelerator programme at CAT

    International Nuclear Information System (INIS)

    The Accelerator Programme at the Centre for Advanced Technology (CAT), Indore, has very broad based concept under which all types of accelerators are to be taken up for design and fabrication. This centre will be housing a wide variety of accelerators to serve as a common facility for the universities, national laboratories in addition to laboratories under the Department of Atomic Energy. In the first phase of the programme, a series of electron accelerators are designed and fabricated. They are synchrotron radiation sources of 450 MeV (INDUS-I) and of 2 GeV (INDUS-II), microtron upto energy of 20 MeV, linear accelerator upto 20 MeV, and DC Accelerator for industrial irradiation upto 750 KeV and 20 KW. A proton accelerator of 300 MeV with 20 MeV linac injector is also designed. CAT is also developing a strong base for support technologies like ultra high vacuum, radio frequency and microwaves, DC pulsed and superconducting magnets, power supplies and controls etc. These technologies are very useful for other industrial applications also. To develop user groups to utilise INDUS-II synchrotron radiation source, a batch production of rotating Anode X-ray generators with power supplies has been initiated. So also, the sputter ion pumps, electron guns, turbo molecular pumps are brought into batch production. (author)

  7. Reactor Physics Programme

    Energy Technology Data Exchange (ETDEWEB)

    De Raedt, C

    2000-07-01

    The Reactor Physics and Department of SCK-CEN offers expertise in various areas of reactor physics, in particular in neutronics calculations, reactor dosimetry, reactor operation, reactor safety and control and non-destructive analysis on reactor fuel. This expertise is applied within the Reactor Physics and MYRRHA Research Department's own research projects in the VENUS critical facility, in the BR1 reactor and in the MYRRHA project (this project aims at designing a prototype Accelerator Driven System). Available expertise is also used in programmes external to the Department such as the reactor pressure steel vessel programme, the BR2 reactor dosimetry, and the preparation and interpretation of irradiation experiments. Progress and achievements in 1999 in the following areas are reported on: (1) investigations on the use of military plutonium in commercial power reactors; (2) neutron and gamma calculations performed for BR-2 and for other reactors; (3) the updating of neutron and gamma cross-section libraries; (4) the implementation of reactor codes; (6) the management of the UNIX workstations; and (6) fuel cycle studies.

  8. Copernicus Earth observation programme

    Science.gov (United States)

    Žlebir, Silvo

    European Earth observation program Copernicus is an EU-wide programme that integrates satellite data, in-situ data and modeling to provide user-focused information services to support policymakers, researchers, businesses and citizens. Land monitoring service and Emergency service are fully operational already, Atmosphere monitoring service and Marine environment monitoring service are preoperational and will become fully operational in the following year, while Climate change service and Security service are in an earlier development phase. New series of a number of dedicated satellite missions will be launched in the following years, operated by the European Space Agency and EUMETSAT, starting with Sentinel 1A satellite early this year. Ground based, air-borne and sea-borne in-situ data are provided by different international networks and organizations, EU member states networks etc. European Union is devoting a particular attention to secure a sustainable long-term operational provision of the services. Copernicus is also stated as a European Union’s most important contribution to Global Earth Observation System of Systems (GEOSS). The status and the recent development of the Copernicus programme will be presented, together with its future perspective. As Copernicus services have already demonstrated their usability and effectiveness, some interesting cases of their deployment will be presented. Copernicus free and open data policy, supported by a recently adopted EU legislative act, will also be presented.

  9. RDandD Programme 2010. Programme for research, development and demonstration of methods for the management and disposal of nuclear waste

    Energy Technology Data Exchange (ETDEWEB)

    2010-09-15

    RDandD Programme 2010 presents SKB's plans for research, development and demonstration during the period 2011-2016. SKB's activities are divided into two main areas: the programme for low- and intermediate-level waste (the LILW Programme) and the Nuclear Fuel Programme. Operation of the existing facilities takes place within the Operational Process. RDandD Programme 2010 consists of five parts: Part I Overall plan of action Part II The LILW Programme Part III The Nuclear Fuel Programme Part IV Research for assessment of long-term safety Part V Social science research RDandD Programme 2007 was mainly focused on development of technology to realize the final repository for spent nuclear fuel. The efforts described were aimed at gaining a greater knowledge of long-term safety and compiling technical supporting documentation for applications under the Nuclear Activities Act for the final repository for spent nuclear fuel and under the Environmental Code for the final repository system. Many important results from these efforts are reported in this programme. The integrated account of the results will be presented in applications submitted in early 2011. The regulatory review of RDandD Programme 2007 and its supplement called for clarifications of plans and programmes for the final repository for short-lived radioactive waste, SFR, and the final repository for long-lived waste, SFL. This RDandD Programme describes these plans more clearly

  10. RDandD Programme 2010. Programme for research, development and demonstration of methods for the management and disposal of nuclear waste

    International Nuclear Information System (INIS)

    RDandD Programme 2010 presents SKB's plans for research, development and demonstration during the period 2011-2016. SKB's activities are divided into two main areas: the programme for low- and intermediate-level waste (the LILW Programme) and the Nuclear Fuel Programme. Operation of the existing facilities takes place within the Operational Process. RDandD Programme 2010 consists of five parts: Part I Overall plan of action Part II The LILW Programme Part III The Nuclear Fuel Programme Part IV Research for assessment of long-term safety Part V Social science research RDandD Programme 2007 was mainly focused on development of technology to realize the final repository for spent nuclear fuel. The efforts described were aimed at gaining a greater knowledge of long-term safety and compiling technical supporting documentation for applications under the Nuclear Activities Act for the final repository for spent nuclear fuel and under the Environmental Code for the final repository system. Many important results from these efforts are reported in this programme. The integrated account of the results will be presented in applications submitted in early 2011. The regulatory review of RDandD Programme 2007 and its supplement called for clarifications of plans and programmes for the final repository for short-lived radioactive waste, SFR, and the final repository for long-lived waste, SFL. This RDandD Programme describes these plans more clearly

  11. Energy technology programmes 1993-1998. Evaluation report

    Energy Technology Data Exchange (ETDEWEB)

    1999-09-01

    In the late 1980s Finland`s Ministry of Trade and Industry (KTM) initiated a series of research and development (R and D) programmes in the field of energy technology. Subsequently, in 1993, it launched a further suite of eleven Energy Technology Programmes scheduled to run over the period 1993-1998. Aimed at the development of efficient and environmentally sound energy technologies intended to be competitive in the international marketplace, the programmes sought to involve the research, industrial and public sectors in some FIM 1.2 billion of research and development activity. The technology areas spanned: Combustion and gasification techniques Bioenergy, Advanced energy systems and technologies (e.g. wind, solar energy), Fusion, Energy and environmental technology, Energy and the environment in transportation, Energy use in buildings, Energy in steel and metal production, Energy in paper and board production, District heating, Electricity distribution automation. In early 1995, the Technology Development Centre of Finland (Tekes) assumed responsibility for the funding, management and administration of the programmes. As the final year of activities began, Tekes commissioned Technopolis to assemble a team to conduct a major review of all eleven programmes over the course of 1998. The broad aim of the exercise was to review the experience of the eleven technology R and D programmes and to make suggestions for the future. In particular, the intention was to cover a number of distinct levels. Most important were the Programme and Portfolio levels. At the individual Programme level, the review was to comment on the relevance, calibre and impact of programmes, concentrating in particular on the following: Relevance - were programme and project level goals in line with Finnish interests and comparable agendas in other countries; Efficiency - how well were the programmes implemented and managed; Quality - how did the scientific and technological quality of the work

  12. CAMAC modular programmable function generator

    International Nuclear Information System (INIS)

    A CAMAC modular programmable function generator has been developed. The device contains a 1024 word by 12-bit memory, a 12-bit digital-to-analog converter with a 600 ns settling time, an 18-bit programmable frequency register, and two programmable trigger output registers. The trigger registers can produce programmed output logic transitions at various (binary) points in the output function curve, and are used to synchronize various other data acquisition devices with the function curve

  13. Climate Ambassador Programmes in Municipalities

    DEFF Research Database (Denmark)

    Jørgensen, Michael Søgaard; Pedersen, Stine Rahbek

    2016-01-01

    Some Danish municipalities have developed ambassador programmes which generate environmental and climate change mitigation efforts in local public administrations and institutions. This chapter analyses the characteristics and experiences of four ambassador programmes now operating...... in the municipalities of Furesø, Lyngby-Taarbæk, Frederiksberg and Hvidovre. Two of the ambassador programmes presented here focus primarily on climate change mitigation initiatives, and two have a broader focus on sustainable development. Important elements for the impact of these programmes are the networking among...

  14. What promotes sustainability in Safe Community programmes?

    Directory of Open Access Journals (Sweden)

    Lindqvist Kent

    2009-01-01

    . Increased relational resources facilitated the transfer of information. A regular flow of information to policy-makers, residents, and staff was needed in order to integrate safety programmes into routines. Adopting a bottom-up approach requires that informal and ad hoc activities in information management be replaced by formalized, organizationally sanctioned routines. In contrast to injury prevention, which focuses on technical solutions, safety promotion tries to influence attitudes. Collaboration with the media was an area that could be improved.

  15. 'Mother of all Sport’: an evaluation of a women’s community sports programme

    OpenAIRE

    Mahedy, Tracy

    2015-01-01

    peer-reviewed The purpose of the ‘Mother of all Sport’ programme is to investigate the effect of a physical activity programme on women in disadvantaged communities and evaluate whether this type of programme can encourage women to participate in physical activity in their local community. This research project subsequently examines women's perception of sport and physical activity and explores whether a community approach to sport and physical activity can change women's vi...

  16. ‘Mother of all sport’: an evaluation of a women’s community sports programme

    OpenAIRE

    Mahedy, Tracy; MacPhail, Ann

    2015-01-01

    peer-reviewed The purpose of the ‘Mother of all Sport’ programme is to investigate the effect of a physical activity programme on women in disadvantaged communities and evaluate whether this type of programme can encourage women to participate in physical activity in their local community. This research project subsequently examines women's perception of sport and physical activity and explores whether a community approach to sport and physical activity can change women's vi...

  17. A Study on the Translation of Erasmus+Programme Guide

    Institute of Scientific and Technical Information of China (English)

    韩姣

    2016-01-01

    In 2014, the European Commission carries out a new programme----"Erasmus+ Programme". It increases people's skills and employability through provides grants to support students, trainees, staff and volunteers to study or work abroad and organizations to organize activities. In order to let more Chinese people know about"Erasmus+Programme"and participate in it, the author of the paper just selects its introductory part Erasmus+Programme Guide to translate. While translating, the author of the paper finds that certain translation theory and correspondent translation methods must be adopted to guide the translation in order to produce a correct and expressive version. The paper is hence intended to study the translation theory and translation methods adopted in the translation of Erasmus+Programme Guide.

  18. Programmable ferroelectric tunnel memristor

    Directory of Open Access Journals (Sweden)

    Andy eQuindeau

    2014-02-01

    Full Text Available We report an analogously programmable memristor based on genuine electronic resistive switching combining ferroelectric switching and electron tunneling. The tunnel current through an 8 unit cell thick epitaxial Pb(Zr[0.2]Ti[0.8]O[3] film sandwiched between La[0.7]Sr[0.3]MnO[3] and cobalt electrodes obeys the Kolmogorov-Avrami-Ishibashi model for bidimensional growth with a characteristic switching time in the order of 10^-7 seconds. The analytical description of switching kinetics allows us to develop a characteristic transfer function that has only one parameter viz. the characteristic switching time and fully predicts the resistive states of this type of memristor.

  19. Country programme review Bangladesh

    International Nuclear Information System (INIS)

    A five-expert mission was organized from 21-26 August 1993 and this document reflects the findings and recommendations of the team. Intensive contacts with heads of institutions, scientists and decision making persons in various sectors in the country were co-ordinated by the Bangladesh Atomic Energy Commission. The terms of reference of the mission were: To assess the on-going TC projects; to assist the Bangladesh nationals to finalize the formulation of the new requests for 1995-96 TC programme and to establish priority areas with regard to the introduction of national projects involving accelerated technological transfer in order to catalyze national development plans in specific areas; to examine institutional framework suitable for the introduction of these priority nuclear techniques

  20. The effect a of community-based social marketing campaign on recruitment and retention of low-income groups into physical activity programmes - a controlled before-and-after study

    Science.gov (United States)

    2012-01-01

    Background The beneficial effect of physical activity for the prevention of a range of chronic diseases is widely acknowledged. These conditions are most prevalent in low-income groups where physical activity levels are consistently lower. Social marketing is the government’s recommended approach to promoting physical activity but evidence of its effectiveness is limited. The purpose of this study was to examine the effect of a social marketing campaign on the monthly recruitment, attendance and retention levels at a community-based physical activity programme in a low income area. Methods A six-month social marketing campaign was designed and delivered in a highly-deprived suburban neighbourhood. Analysis of variance was used to assess effects on recruitment and attendance. χ2 tests of independence were used to compare dropouts and adherers and effectiveness of recruitment mechanisms. Percentages were used to compare adherence rates at intervention, pre-existing sessions in the intervention area and control area sessions. Results Attendance data were collected weekly and presented and analysed monthly to provide a view of changing participation over the six month intervention period, as compared to attendance at pre-existing sessions in the intervention area and in a control area. Recruitment into intervention sessions was significantly greater than into pre-existing and control area sessions in Month 1 (18.13v1.04 p = .007, 18.13v.30 p=.005), Month 5 (3.45v.84 p=.007, 3.45v.30 pmarketing techniques (posters/outdoor banners/flyers) had the greatest influence on recruitment compared to word of mouth communication (84.5%v15.5%). In months five and six word of mouth influenced 57.5% of new recruits. Conclusions Direct comparisons with other programmes were difficult due to a lack of standard definitions of recruitment and adherence and limited reporting of findings. However when compared to pre-existing sessions and sessions delivered in a control area

  1. The effect a of community-based social marketing campaign on recruitment and retention of low-income groups into physical activity programmes - a controlled before-and-after study

    Directory of Open Access Journals (Sweden)

    Withall Janet

    2012-10-01

    Full Text Available Abstract Background The beneficial effect of physical activity for the prevention of a range of chronic diseases is widely acknowledged. These conditions are most prevalent in low-income groups where physical activity levels are consistently lower. Social marketing is the government’s recommended approach to promoting physical activity but evidence of its effectiveness is limited. The purpose of this study was to examine the effect of a social marketing campaign on the monthly recruitment, attendance and retention levels at a community-based physical activity programme in a low income area. Methods A six-month social marketing campaign was designed and delivered in a highly-deprived suburban neighbourhood. Analysis of variance was used to assess effects on recruitment and attendance. χ2 tests of independence were used to compare dropouts and adherers and effectiveness of recruitment mechanisms. Percentages were used to compare adherence rates at intervention, pre-existing sessions in the intervention area and control area sessions. Results Attendance data were collected weekly and presented and analysed monthly to provide a view of changing participation over the six month intervention period, as compared to attendance at pre-existing sessions in the intervention area and in a control area. Recruitment into intervention sessions was significantly greater than into pre-existing and control area sessions in Month 1 (18.13v1.04 p = .007, 18.13v.30 p=.005, Month 5 (3.45v.84 p=.007, 3.45v.30 p Conclusions Direct comparisons with other programmes were difficult due to a lack of standard definitions of recruitment and adherence and limited reporting of findings. However when compared to pre-existing sessions and sessions delivered in a control area, monthly attendance patterns indicated that a reasonably well funded social marketing campaign increased recruitment into exercise sessions, maintained good levels of attendance and reasonable levels

  2. Programmes of measures under the water framework directive – a comparative case study

    DEFF Research Database (Denmark)

    Baaner, Lasse

    2011-01-01

    direct the authorities’ activities with regard to water management. It concludes that there are major differences in the precision of the measures, the range of legal instruments used, and in the focus on active and direct management of the aquatic environment. The Danish programme seems to facilitate...... the establishment of an adaptive management, whereas the Swedish and Norwegian programmes seem to take a more integrative approach.......The water framework directive requires programmes of measures composed by the Member States, in order to achieve its environmental objectives. This article examines three programmes of measures for river basins in Denmark, Sweden, and Norway, with a focus on the differences in how the programmes...

  3. Programmable architecture for quantum computing

    NARCIS (Netherlands)

    Chen, J.; Wang, L.; Charbon, E.; Wang, B.

    2013-01-01

    A programmable architecture called “quantum FPGA (field-programmable gate array)” (QFPGA) is presented for quantum computing, which is a hybrid model combining the advantages of the qubus system and the measurement-based quantum computation. There are two kinds of buses in QFPGA, the local bus and t

  4. An automatic bibliography indexing programme

    Directory of Open Access Journals (Sweden)

    J. W. Morris

    1974-12-01

    Full Text Available A relatively simple FORTRAN IV programme, designed for a small computer, for author and key-word indexes to bibliographic records is described, and examples of output are given. It is com­pared with some other systems. Suggested improvements to the programme are given.

  5. Japan's Eco-School Programme

    Science.gov (United States)

    Mori, Masayuki

    2007-01-01

    Since 1997, several ministries in Japan have collaborated on an eco-school programme, which applies to both newly constructed and renovated school buildings, in an effort to make its schools more environmentally friendly. The programme equips school buildings with ecological features such as photovoltaic cells, solar thermal collectors, other new…

  6. International Geological Correlation Programme (IGCP) /International Geoscience Programme (IGCP)

    Institute of Scientific and Technical Information of China (English)

    WolfgangEder; MargaretePatzak

    2004-01-01

    Although many countries, especially from the developing world, share the most exciting geological features, geological structures and natural resources, research activities at various institutions are undertaken in isolation. The IGCP is unique as an international Programme that brings together several thousands of scientists from different disciplines, to stimulate dialogue and facilitate communication among

  7. The Agency's technical co-operation programme with Sri Lanka 1983-1993 country programme summaries

    International Nuclear Information System (INIS)

    This report contains a review of the Agency's technical co-operation activities in Sri Lanka carried out during 1983-1993. In terms of coverage and analytical depth, country programmes summaries stand somewhere midway between in-depth country programme evaluations and individual project evaluations. They attempt to provide a comprehensive, descriptive picture of the Agency's co-operation with a Member State in a manner that will be particularly useful for programming decisions. The attempt is very much to describe - largely through statistical data - not to provide independent analysis and evaluation

  8. The Agency's technical co-operation programme with Viet Nam 1983-1993 country programme summaries

    International Nuclear Information System (INIS)

    This report contains a review of the Agency's technical co-operation activities in Viet Nam carried out during 1983-1993. In terms of coverage and analytical depth, country programmes summaries stand somewhere midway between in-depth country programme evaluations and individual project evaluations. They attempt to provide a comprehensive, descriptive picture of the Agency's co-operation with a Member State in a manner that will be particularly useful for programming decisions. The attempt is very much to describe - largely through statistical data - not to provide independent analysis and evaluation

  9. The Agency's technical co-operation programme with Colombia 1983-1993 country programme summaries

    International Nuclear Information System (INIS)

    This report contains a review of the Agency's technical co-operation activities in Colombia carried out during 1983-1993. In terms of coverage and analytical depth, country programmes summaries stand somewhere midway between in-depth country programme evaluations and individual project evaluations. They attempt to provide a comprehensive, descriptive picture of the Agency's co-operation with a Member State in a manner that will be particularly useful for programming decisions. The attempt is very much to describe - largely through statistical data - not to provide independent analysis and evaluation

  10. The Agency's technical co-operation programme with Bolivia 1983-1993 country programme summaries

    International Nuclear Information System (INIS)

    This report contains a review of the Agency's technical co-operation activities in Bolivia carried out during 1983-1993. In terms of coverage and analytical depth, country programmes summaries stand somewhere midway between in-depth country programme evaluations and individual project evaluations. They attempt to provide a comprehensive, descriptive picture of the Agency's co-operation with a Member State in a manner that will be particularly useful for programming decisions. The attempt is very much to describe - largely through statistical data - not to provide independent analysis and evaluation

  11. The Agency's technical co-operation programme with Greece 1983-1993 country programme summaries

    International Nuclear Information System (INIS)

    This report contains a review of the Agency's technical co-operation activities in Greece carried out during 1983-1993. In terms of coverage and analytical depth, country programmes summaries stand somewhere midway between in-depth country programme evaluations and individual project evaluations. They attempt to provide a comprehensive, descriptive picture of the Agency's co-operation with a Member State in a manner that will be particularly useful for programming decisions. The attempt is very much to describe - largely through statistical data - not to provide independent analysis and evaluation

  12. The Agency's technical co-operation programme with Hungary 1983-1993 country programme summaries

    International Nuclear Information System (INIS)

    This report contains a review of the Agency's technical co-operation activities in Hungary carried out during 1983-1993. In terms of coverage and analytical depth, country programmes summaries stand somewhere midway between in-depth country programme evaluations and individual project evaluations. They attempt to provide a comprehensive, descriptive picture of the Agency's co-operation with a Member State in a manner that will be particularly useful for programming decisions. The attempt is very much to describe - largely through statistical data - not to provide independent analysis and evaluation

  13. The Agency's technical co-operation programme with Malaysia 1984-1994 country programme summaries

    International Nuclear Information System (INIS)

    This report contains a review of the Agency's technical co-operation activities in Malaysia carried out during 1984-1994. In terms of coverage and analytical depth, country programmes summaries stand somewhere midway between in-depth country programme evaluations and individual project evaluations. They attempt to provide a comprehensive, descriptive picture of the Agency's co-operation with a Member State in a manner that will be particularly useful for programming decisions. The attempt is very much to describe - largely through statistical data - not to provide independent analysis and evaluation

  14. The Agency's technical co-operation programme with Nicaragua 1983-1993 country programme summaries

    International Nuclear Information System (INIS)

    This report contains a review of the Agency's technical co-operation activities in Nicaragua carried out during 1983-1993. In terms of coverage and analytical depth, country programmes summaries stand somewhere midway between in-depth country programme evaluations and individual project evaluations. They attempt to provide a comprehensive, descriptive picture of the Agency's co-operation with a Member State in a manner that will be particularly useful for programming decisions. The attempt is very much to describe - largely through statistical data - not to provide independent analysis and evaluation

  15. The Agency's technical co-operation programme with Bolivia 1986-1996 country programme summaries

    International Nuclear Information System (INIS)

    This report contains a review of the Agency's technical co-operation activities in Bolivia carried out during 1986-1996. In terms of coverage and analytical depth, country programmes summaries stand somewhere midway between in-depth country programme evaluations and individual project evaluations. They attempt to provide a comprehensive, descriptive picture of the Agency's co-operation with a Member State in a manner that will be particularly useful for programming decisions. The attempt is very much to describe - largely through statistical data - not to provide independent analysis and evaluation

  16. The Agency's technical co-operation programme with Guatemala 1985-1995 country programme summaries

    International Nuclear Information System (INIS)

    This report contains a review of the Agency's technical co-operation activities in Guatemala carried out during 1985-1995. In terms of coverage and analytical depth, country programmes summaries stand somewhere midway between in-depth country programme evaluations and individual project evaluations. They attempt to provide a comprehensive, descriptive picture of the Agency's co-operation with a Member State in a manner that will be particularly useful for programming decisions. The attempt is very much to describe - largely through statistical data - not to provide independent analysis and evaluation

  17. Clinical application of free KISS lateral femoral circumflex artery perforator flap in repairing defects of limbs%游离旋股外侧动脉穿支KISS皮瓣修复四肢创面的临床应用

    Institute of Scientific and Technical Information of China (English)

    唐修俊; 魏在荣; 王波; 王达利; 孙广峰; 金文虎; 李海

    2015-01-01

    Objective To summarize the clinical efficacy of free KISS lateral femoral circumflex artery perforator flap in repairing defects of limbs.Methods Twelve cases were suffered wound surface defects on hands and feet.And the defects were repaired by flap construction from October,2010 to May,2013,based on the characteristics of the defects combined with anatomical features of the free lateral femoral circumflex artery perforator flap.Length of flap was adopted as the width for direct suture in the flap donor.Results Postoperative flap and donor area preliminarily healed.There was no vascular crisis.Twelve cases received 6-18 months followed-up (averaged of 12 months).The skin flap was good in color and texture.The dorsal flap was a bit bloated.Linear scar was remained in distal flap donor area.The quadriceps muscle power level 5,knee flexion,extension 10°-180°.Quadriceps strength,knee flexion and stretch activities were all normal.The flaps recovered protective sense.Four cases had tendon adhesion after hand tendon transplantation.The finger function was well recovered after release.At the last followup,the functions of the upper limbs were evaluated according to the trial evaluation standard of the Hand Surgery Association of Chinese Medical Association:6 cases were excellent,1 case was good,and 1 case was qualified.Conclusion The design of the lobulated tissue flap of the lateral femoral circumflex artery descending branch is flexible.Large area of the surface defect can be repaired.The flap donor area is directly sutured.It is an ideal method to repair the wound tissue defect.%目的 总结游离旋股外侧动脉穿支KISS皮瓣在修复四肢创面中的临床疗效. 方法 2010年10月-2013年5月,根据手足部创面的特点,结合旋股外侧动脉穿支解剖特点设计分叶皮瓣,通过皮瓣重组(KISS)修复手足部创面缺损12例,将皮瓣的长度变成宽度使皮瓣供区直接缝合. 结果 术后皮瓣及供区Ⅰ

  18. The Durham Micro-Optics Programme

    OpenAIRE

    Schmoll, J.; Dubbeldam, C. M.; Robertson, D. J.; Yao, J

    2005-01-01

    The Durham Micro-optics Programme was established to develop key components to be used for integral field spectrographs for upcoming instrumentation projects, focussing on currently existing telescopes as well as on the next generation of ELTs. These activities include monolithic multi-optics machining and grinding, optical surface improvement using various post-polishing techniques and replication of micro-optical components. While these developments have mostly slicer-type IFUs in mind, als...

  19. Macroeconomic aspects of the French nuclear programme

    International Nuclear Information System (INIS)

    The nuclear programme is a boost both to economic and industrial activity and to research and development: it provides 120 000 jobs in France and has a positive influence on the national economic situation. After illustrating this statement, the author draws up a balance sheet for the nuclear industry, demonstrating the positive contribution of this form of energy compared with the results which would have been obtained by a different policy founded on electricity derived from coal

  20. The Wind Energy programme - SFOE Research Programme 2000 - 2003; Programm Wind. Konzept BFE-Forschungsprogramm 'Wind' 2000 - 2003

    Energy Technology Data Exchange (ETDEWEB)

    Horbaty, R.

    2001-07-01

    This document, issued by the Swiss Federal Office of Energy (SFOE) describes the concept behind the Swiss wind energy programme. The first part of the report discusses the origins and development of the wind energy programme in Switzerland, discussing the importance of wind energy and policy matters associated with its promotion. The experience gained during the previous research programmes is reviewed. The degree to which targets were reached, promotional activities, the central government's own wind energy activities and the results of a programme evaluation are discussed. Lists of projects that have been realised and activities that have been carried out are presented and positive and negative influences on development are noted. A second part is dedicated to the goals of the wind energy programme in terms of target figures for the year 2010 and the strategies chosen to reach these goals, including pilot and demonstration projects (P and D) and promotional activities. Details of the P and D programme including lists of wind-power projects to be supported, the priorities that have been set and information and further education that is to be provided, are given. New activities in the wind power area such as the development of new type of wind turbine especially suited to alpine conditions are discussed. The role of the Swiss Association for Wind Energy 'Suisse Eole' as a network-partner in the wind energy programme is discussed. An appendix provides details of wind energy projects in Switzerland, market partners and customers. The results of a survey made of wind energy activities at Swiss institutes of higher education are presented.

  1. Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3

    DEFF Research Database (Denmark)

    Bousquet, J; Farrell, J; Crooks, G;

    2016-01-01

    Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS ...... learnt, including emerging technologies for individualised and predictive medicine. This strategy has already been applied to the chronic respiratory disease action plan of the European Innovation Partnership on Active and Healthy Ageing.......Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS...

  2. Changes in activity of industrial enzyme preparations irradiated with sterilizing doses. Part of a coordinated programme on factors influencing the utilization of food irradiation process

    International Nuclear Information System (INIS)

    Experiments were carried out to investigate the efficacy of irradiation to sterilize enzyme preparations. Irradiation doses up to 25 kGy caused no changes in basic organoleptic properties of commercial rennin preparations. Dose rate (from 0.5 to 13.5 kGy/hr) has no influence on the changes in enzyme activity during the storage period of 3 months. Doses ranging from 8 to 12 kGy are sufficient to sterilize commercial enzyme preparations. Non-purified, crude rennin preparations appear to be more resistant to radiation than purified samples. Rennin preparations purified by dialysis and treated with 25 kGy resulted in a reduction of activity of 20%. The activity of preparations purified by gel filtration was reduced to 50% when treated with the same dose

  3. The IAEA isotope and radiation programme

    International Nuclear Information System (INIS)

    The IAEA isotope and radiation programme is characterized by the very large number of topics dealt with and the broad range of activities where nuclear methods and techniques are utilized. The main activities of the programme can be grouped into: food and agriculture, human health and life science, industry and physical science, and laboratory services. Radioisotope and radiation based techniques are applied to such areas as plant breeding, insect and pest control, soil fertility studies, animal health and production, studies on the fate of pesticide residues and radionuclides in the food chain, and food preservation. General objectives of the second group of activities are to assist hospitals and research institutes in developing member states in the introduction and development of radionuclide tracers in medical diagnosis and research, to promote use of radiation therapy for cancer treatment, etc. The major objective of the third group is to foster research and application of nuclear methodologies for industrial applications in developing countries. The Agency's Laboratories at Seibersdorf and in Vienna and the Monaco Laboratory play a relevant role in providing laboratory services as a back-up for various programmes, and in the training of scientists from developing countries. (Nogami, K.)

  4. Radon programme in the Czech Republic

    International Nuclear Information System (INIS)

    The framework of the Radon programme in the Czech republic includes both precautionary measures and interventions. The programme informally started in early eighties has been now incorporated in national legislation (Atomic Act, Radiation Protection Decree, etc.). Aim of precautionary measures is to avert construction of building above natural radiation guidance levels (200 Bq/m3 for indoor radon concentration and 0.5 Sv/h for gamma dose rate) by protection of new buildings against soil radon ingress, by regulation of natural radioactivity in building materials and supplied water. Aim of interventions is to identify buildings affected by enhanced natural radioactivity and help owners to put into effect reasonable remedial measures. Two sets of intervention levels for indoor natural exposure were established: guidance intervention levels 400 Bq/m3 (indoor radon), 1.0 Sv/h (indoor gamma dose rate) and limit values 4000 Bq/m3 and 10 Sv/h. The radon programme is based both on governmental and private activities. The governmental activities include representative and targeted indoor radon survey, subsidy for radon mitigation, mitigation test measurements and public information on radon issue. The private activities include radon measurement (radon index of building site, indoor measurements, radon diagnosis) and remedial measures. More than 100 commercial companies were authorised by Radiation Protection Authority (SUJB) to provide these measurements

  5. Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5).

    Science.gov (United States)

    Bousquet, J; Farrell, J; Crooks, G; Hellings, P; Bel, E H; Bewick, M; Chavannes, N H; de Sousa, J Correia; Cruz, A A; Haahtela, T; Joos, G; Khaltaev, N; Malva, J; Muraro, A; Nogues, M; Palkonen, S; Pedersen, S; Robalo-Cordeiro, C; Samolinski, B; Strandberg, T; Valiulis, A; Yorgancioglu, A; Zuberbier, T; Bedbrook, A; Aberer, W; Adachi, M; Agusti, A; Akdis, C A; Akdis, M; Ankri, J; Alonso, A; Annesi-Maesano, I; Ansotegui, I J; Anto, J M; Arnavielhe, S; Arshad, H; Bai, C; Baiardini, I; Bachert, C; Baigenzhin, A K; Barbara, C; Bateman, E D; Beghé, B; Kheder, A Ben; Bennoor, K S; Benson, M; Bergmann, K C; Bieber, T; Bindslev-Jensen, C; Bjermer, L; Blain, H; Blasi, F; Boner, A L; Bonini, M; Bonini, S; Bosnic-Anticevitch, S; Boulet, L P; Bourret, R; Bousquet, P J; Braido, F; Briggs, A H; Brightling, C E; Brozek, J; Buhl, R; Burney, P G; Bush, A; Caballero-Fonseca, F; Caimmi, D; Calderon, M A; Calverley, P M; Camargos, P A M; Canonica, G W; Camuzat, T; Carlsen, K H; Carr, W; Carriazo, A; Casale, T; Cepeda Sarabia, A M; Chatzi, L; Chen, Y Z; Chiron, R; Chkhartishvili, E; Chuchalin, A G; Chung, K F; Ciprandi, G; Cirule, I; Cox, L; Costa, D J; Custovic, A; Dahl, R; Dahlen, S E; Darsow, U; De Carlo, G; De Blay, F; Dedeu, T; Deleanu, D; De Manuel Keenoy, E; Demoly, P; Denburg, J A; Devillier, P; Didier, A; Dinh-Xuan, A T; Djukanovic, R; Dokic, D; Douagui, H; Dray, G; Dubakiene, R; Durham, S R; Dykewicz, M S; El-Gamal, Y; Emuzyte, R; Fabbri, L M; Fletcher, M; Fiocchi, A; Fink Wagner, A; Fonseca, J; Fokkens, W J; Forastiere, F; Frith, P; Gaga, M; Gamkrelidze, A; Garces, J; Garcia-Aymerich, J; Gemicioğlu, B; Gereda, J E; González Diaz, S; Gotua, M; Grisle, I; Grouse, L; Gutter, Z; Guzmán, M A; Heaney, L G; Hellquist-Dahl, B; Henderson, D; Hendry, A; Heinrich, J; Heve, D; Horak, F; Hourihane, J O' B; Howarth, P; Humbert, M; Hyland, M E; Illario, M; Ivancevich, J C; Jardim, J R; Jares, E J; Jeandel, C; Jenkins, C; Johnston, S L; Jonquet, O; Julge, K; Jung, K S; Just, J; Kaidashev, I; Kaitov, M R; Kalayci, O; Kalyoncu, A F; Keil, T; Keith, P K; Klimek, L; Koffi N'Goran, B; Kolek, V; Koppelman, G H; Kowalski, M L; Kull, I; Kuna, P; Kvedariene, V; Lambrecht, B; Lau, S; Larenas-Linnemann, D; Laune, D; Le, L T T; Lieberman, P; Lipworth, B; Li, J; Lodrup Carlsen, K; Louis, R; MacNee, W; Magard, Y; Magnan, A; Mahboub, B; Mair, A; Majer, I; Makela, M J; Manning, P; Mara, S; Marshall, G D; Masjedi, M R; Matignon, P; Maurer, M; Mavale-Manuel, S; Melén, E; Melo-Gomes, E; Meltzer, E O; Menzies-Gow, A; Merk, H; Michel, J P; Miculinic, N; Mihaltan, F; Milenkovic, B; Mohammad, G M Y; Molimard, M; Momas, I; Montilla-Santana, A; Morais-Almeida, M; Morgan, M; Mösges, R; Mullol, J; Nafti, S; Namazova-Baranova, L; Naclerio, R; Neou, A; Neffen, H; Nekam, K; Niggemann, B; Ninot, G; Nyembue, T D; O'Hehir, R E; Ohta, K; Okamoto, Y; Okubo, K; Ouedraogo, S; Paggiaro, P; Pali-Schöll, I; Panzner, P; Papadopoulos, N; Papi, A; Park, H S; Passalacqua, G; Pavord, I; Pawankar, R; Pengelly, R; Pfaar, O; Picard, R; Pigearias, B; Pin, I; Plavec, D; Poethig, D; Pohl, W; Popov, T A; Portejoie, F; Potter, P; Postma, D; Price, D; Rabe, K F; Raciborski, F; Radier Pontal, F; Repka-Ramirez, S; Reitamo, S; Rennard, S; Rodenas, F; Roberts, J; Roca, J; Rodriguez Mañas, L; Rolland, C; Roman Rodriguez, M; Romano, A; Rosado-Pinto, J; Rosario, N; Rosenwasser, L; Rottem, M; Ryan, D; Sanchez-Borges, M; Scadding, G K; Schunemann, H J; Serrano, E; Schmid-Grendelmeier, P; Schulz, H; Sheikh, A; Shields, M; Siafakas, N; Sibille, Y; Similowski, T; Simons, F E R; Sisul, J C; Skrindo, I; Smit, H A; Solé, D; Sooronbaev, T; Spranger, O; Stelmach, R; Sterk, P J; Sunyer, J; Thijs, C; To, T; Todo-Bom, A; Triggiani, M; Valenta, R; Valero, A L; Valia, E; Valovirta, E; Van Ganse, E; van Hage, M; Vandenplas, O; Vasankari, T; Vellas, B; Vestbo, J; Vezzani, G; Vichyanond, P; Viegi, G; Vogelmeier, C; Vontetsianos, T; Wagenmann, M; Wallaert, B; Walker, S; Wang, D Y; Wahn, U; Wickman, M; Williams, D M; Williams, S; Wright, J; Yawn, B P; Yiallouros, P K; Yusuf, O M; Zaidi, A; Zar, H J; Zernotti, M E; Zhang, L; Zhong, N; Zidarn, M; Mercier, J

    2016-01-01

    Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre les MAladies Chroniques pour un VIeillissement Actif) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AIRWAYS ICPs network. It is deployed in collaboration with the World Health Organization Global Alliance against Chronic Respiratory Diseases (GARD). The European Innovation Partnership on Active and Healthy Ageing has proposed a 5-step framework for developing an individual scaling up strategy: (1) what to scale up: (1-a) databases of good practices, (1-b) assessment of viability of the scaling up of good practices, (1-c) classification of good practices for local replication and (2) how to scale up: (2-a) facilitating partnerships for scaling up, (2-b) implementation of key success factors and lessons learnt, including emerging technologies for individualised and predictive medicine. This strategy has already been applied to the chronic respiratory disease action plan of the European Innovation Partnership on Active and Healthy Ageing.

  6. Designing Adult Education Activities: A Case of Civic Education Programmes by National Commission for Civic Education in the Ashaiman Municipality in Ghana

    Science.gov (United States)

    Afriyie, Sally Adwoa

    2015-01-01

    This article discusses the efficiency of the design of educational activities of the National Commission for Civic Education (NCCE) in Ashaiman municipality in Ghana. Using a descriptive case study design, data was collected from seven (7) Community Based Groups in Ashaiman. The results of the study indicated that to a large extent, there was…

  7. Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5).

    Science.gov (United States)

    Bousquet, J; Farrell, J; Crooks, G; Hellings, P; Bel, E H; Bewick, M; Chavannes, N H; de Sousa, J Correia; Cruz, A A; Haahtela, T; Joos, G; Khaltaev, N; Malva, J; Muraro, A; Nogues, M; Palkonen, S; Pedersen, S; Robalo-Cordeiro, C; Samolinski, B; Strandberg, T; Valiulis, A; Yorgancioglu, A; Zuberbier, T; Bedbrook, A; Aberer, W; Adachi, M; Agusti, A; Akdis, C A; Akdis, M; Ankri, J; Alonso, A; Annesi-Maesano, I; Ansotegui, I J; Anto, J M; Arnavielhe, S; Arshad, H; Bai, C; Baiardini, I; Bachert, C; Baigenzhin, A K; Barbara, C; Bateman, E D; Beghé, B; Kheder, A Ben; Bennoor, K S; Benson, M; Bergmann, K C; Bieber, T; Bindslev-Jensen, C; Bjermer, L; Blain, H; Blasi, F; Boner, A L; Bonini, M; Bonini, S; Bosnic-Anticevitch, S; Boulet, L P; Bourret, R; Bousquet, P J; Braido, F; Briggs, A H; Brightling, C E; Brozek, J; Buhl, R; Burney, P G; Bush, A; Caballero-Fonseca, F; Caimmi, D; Calderon, M A; Calverley, P M; Camargos, P A M; Canonica, G W; Camuzat, T; Carlsen, K H; Carr, W; Carriazo, A; Casale, T; Cepeda Sarabia, A M; Chatzi, L; Chen, Y Z; Chiron, R; Chkhartishvili, E; Chuchalin, A G; Chung, K F; Ciprandi, G; Cirule, I; Cox, L; Costa, D J; Custovic, A; Dahl, R; Dahlen, S E; Darsow, U; De Carlo, G; De Blay, F; Dedeu, T; Deleanu, D; De Manuel Keenoy, E; Demoly, P; Denburg, J A; Devillier, P; Didier, A; Dinh-Xuan, A T; Djukanovic, R; Dokic, D; Douagui, H; Dray, G; Dubakiene, R; Durham, S R; Dykewicz, M S; El-Gamal, Y; Emuzyte, R; Fabbri, L M; Fletcher, M; Fiocchi, A; Fink Wagner, A; Fonseca, J; Fokkens, W J; Forastiere, F; Frith, P; Gaga, M; Gamkrelidze, A; Garces, J; Garcia-Aymerich, J; Gemicioğlu, B; Gereda, J E; González Diaz, S; Gotua, M; Grisle, I; Grouse, L; Gutter, Z; Guzmán, M A; Heaney, L G; Hellquist-Dahl, B; Henderson, D; Hendry, A; Heinrich, J; Heve, D; Horak, F; Hourihane, J O' B; Howarth, P; Humbert, M; Hyland, M E; Illario, M; Ivancevich, J C; Jardim, J R; Jares, E J; Jeandel, C; Jenkins, C; Johnston, S L; Jonquet, O; Julge, K; Jung, K S; Just, J; Kaidashev, I; Kaitov, M R; Kalayci, O; Kalyoncu, A F; Keil, T; Keith, P K; Klimek, L; Koffi N'Goran, B; Kolek, V; Koppelman, G H; Kowalski, M L; Kull, I; Kuna, P; Kvedariene, V; Lambrecht, B; Lau, S; Larenas-Linnemann, D; Laune, D; Le, L T T; Lieberman, P; Lipworth, B; Li, J; Lodrup Carlsen, K; Louis, R; MacNee, W; Magard, Y; Magnan, A; Mahboub, B; Mair, A; Majer, I; Makela, M J; Manning, P; Mara, S; Marshall, G D; Masjedi, M R; Matignon, P; Maurer, M; Mavale-Manuel, S; Melén, E; Melo-Gomes, E; Meltzer, E O; Menzies-Gow, A; Merk, H; Michel, J P; Miculinic, N; Mihaltan, F; Milenkovic, B; Mohammad, G M Y; Molimard, M; Momas, I; Montilla-Santana, A; Morais-Almeida, M; Morgan, M; Mösges, R; Mullol, J; Nafti, S; Namazova-Baranova, L; Naclerio, R; Neou, A; Neffen, H; Nekam, K; Niggemann, B; Ninot, G; Nyembue, T D; O'Hehir, R E; Ohta, K; Okamoto, Y; Okubo, K; Ouedraogo, S; Paggiaro, P; Pali-Schöll, I; Panzner, P; Papadopoulos, N; Papi, A; Park, H S; Passalacqua, G; Pavord, I; Pawankar, R; Pengelly, R; Pfaar, O; Picard, R; Pigearias, B; Pin, I; Plavec, D; Poethig, D; Pohl, W; Popov, T A; Portejoie, F; Potter, P; Postma, D; Price, D; Rabe, K F; Raciborski, F; Radier Pontal, F; Repka-Ramirez, S; Reitamo, S; Rennard, S; Rodenas, F; Roberts, J; Roca, J; Rodriguez Mañas, L; Rolland, C; Roman Rodriguez, M; Romano, A; Rosado-Pinto, J; Rosario, N; Rosenwasser, L; Rottem, M; Ryan, D; Sanchez-Borges, M; Scadding, G K; Schunemann, H J; Serrano, E; Schmid-Grendelmeier, P; Schulz, H; Sheikh, A; Shields, M; Siafakas, N; Sibille, Y; Similowski, T; Simons, F E R; Sisul, J C; Skrindo, I; Smit, H A; Solé, D; Sooronbaev, T; Spranger, O; Stelmach, R; Sterk, P J; Sunyer, J; Thijs, C; To, T; Todo-Bom, A; Triggiani, M; Valenta, R; Valero, A L; Valia, E; Valovirta, E; Van Ganse, E; van Hage, M; Vandenplas, O; Vasankari, T; Vellas, B; Vestbo, J; Vezzani, G; Vichyanond, P; Viegi, G; Vogelmeier, C; Vontetsianos, T; Wagenmann, M; Wallaert, B; Walker, S; Wang, D Y; Wahn, U; Wickman, M; Williams, D M; Williams, S; Wright, J; Yawn, B P; Yiallouros, P K; Yusuf, O M; Zaidi, A; Zar, H J; Zernotti, M E; Zhang, L; Zhong, N; Zidarn, M; Mercier, J

    2016-01-01

    Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre les MAladies Chroniques pour un VIeillissement Actif) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AIRWAYS ICPs network. It is deployed in collaboration with the World Health Organization Global Alliance against Chronic Respiratory Diseases (GARD). The European Innovation Partnership on Active and Healthy Ageing has proposed a 5-step framework for developing an individual scaling up strategy: (1) what to scale up: (1-a) databases of good practices, (1-b) assessment of viability of the scaling up of good practices, (1-c) classification of good practices for local replication and (2) how to scale up: (2-a) facilitating partnerships for scaling up, (2-b) implementation of key success factors and lessons learnt, including emerging technologies for individualised and predictive medicine. This strategy has already been applied to the chronic respiratory disease action plan of the European Innovation Partnership on Active and Healthy Ageing. PMID:27478588

  8. "This Choice Thing Really Works?…?" Changes in Experiences and Engagement of Adolescent Girls in Physical Education Classes, during a School-Based Physical Activity Programme

    Science.gov (United States)

    Mitchell, Fiona; Gray, Shirley; Inchley, Jo

    2015-01-01

    Background: There is a significant amount of research which shows a proportion of girls are not engaging with physical education (PE) in school, resulting in a number of relatively inactive girls within the PE class. These girls are often identified in the literature as "low active", "hard to reach" or "disengaged".…

  9. Adapted Physical Activity Programme and Self-Perception in Obese Adolescents with Intellectual Disability: Between Morphological Awareness and Positive Illusory Bias

    Science.gov (United States)

    Salaun, Laureline; Reynes, Eric; Berthouze-Aranda, Sophie E.

    2014-01-01

    Background: In adolescents with intellectual disability, the management of obesity is a crucial issue, yet also quite complex because of their particular perception of themselves. This study investigated the relationship between self-perception variables and morphological variables and their changes after a 9-month Adapted Physical Activity (APA)…

  10. The BGAN extension programme

    Science.gov (United States)

    Rivera, Juan J.; Trachtman, Eyal; Richharia, Madhavendra

    2005-11-01

    Mobile satellite telecommunications systems have undergone an enormous evolution in the last decades, with the interest in having advanced telecommunications services available on demand, anywhere and at any time, leading to incredible advances. The demand for braodband data is therefore rapidly gathering pace, but current solutions are finding it increasingly difficult to combine large bandwidth with ubiquitous coverage, reliability and portability. The BGAN (Broadband Global Area Network) system, designed to operate with the Inmarsat-4 satellites, provides breakthrough services that meet all of these requirements. It will enable broadband connection on the move, delivering all the key tools of the modern office. Recognising the great impact that Inmarsat's BGAN system will have on the European satellite communications industry, and the benefits that it will bring to a wide range of European industries, in 2003 ESA initiated the "BGAN Extension" project. Its primary goals are to provide the full range of BGAN services to truly mobile platforms, operating in aeronautical, vehicular and maritime environments, and to introduce a multicast service capability. The project is supported by the ARTES Programme which establishes a collaboration agreement between ESA, Inmarsat and a group of key industrial and academic institutions which includes EMS, Logica, Nera and the University of Surrey (UK).

  11. Fusion technology programme

    International Nuclear Information System (INIS)

    In 1982, KfK joined the fusion programme of EURATOM as a further association introducing its experience in nuclear technology. KfK closely cooperates with IPP Garching, the two institutions forming a research unit aiming at planning and realization of future development steps of fusion. KfK has combined its forces in the Nuclear Fusion Project (PKF) with participation of several KfK departments to the project tasks. Previous work of KfK in magnetic fusion has addressed mainly superconducting magnets, plasma heating by cluster ions and studies on structural materials. At present, emphasis of our work has concentrated increasingly on the nuclear part, i.e. the first wall and blanket structures and the elements of the tritium extraction and purification system. Associated to this component development are studies of remote maintenance and safety. Most of the actual work addresses NET, the next step to a demonstration of fusion feasibility. NET is supposed to follow JET, the operating plasma physics experiment of Euratom, on the 1990's. Detailed progress of the work in the past half year is described in this report. (orig./GG)

  12. ALICE pp physics programme

    CERN Document Server

    Kraus, Ingrid

    2009-01-01

    The physics programme of the ALICE experiment at CERN-LHC comprises besides studies of high-energy heavy-ion collisions measurements of proton-proton interactions at unprecedented energies, too. This paper focuses on the global event characterisation in terms of the multiplicity distribution of charged hadrons and mean transverse momentum. These bulk observables become accessible because the detector features excellent track reconstruction, especially at low transverse momenta. The measurement of strange hadrons is of particular interest since the strange-particle phase-space was found to be suppressed beyond canonical reduction at lower center-of-mass energies and the production mechanism of soft particles is not yet fully understood. Here we benefit in particular from particle identification down to very low transverse momentum, i.e. 100 - 300 MeV/c, giving access to spectra and integrated yields of identified hadrons. Equipped with these features, ALICE will play a complementary role w.r.t. other LHC exper...

  13. SUMMER STUDENT LECTURE PROGRAMME

    CERN Multimedia

    Françoise Benz

    2002-01-01

    SUMMER STUDENT LECTURE PROGRAMME Main Auditorium, bldg. 500   DATE TIME LECTURER TITLE Monday 29 July 09:15 - 10:00 R. RATTAZZI Beyond the Standard Model (3/3) 10:15 - 11:00 P. WELLS Experimental test of the SM - LEP (3/3) 11:15 - 12:00 P. WELLS Discussion Session 14:00 - 16:00 R. ASSMANN The CLIC Concept for a Future Particle Collider at the Energy Frontier Tuesday 30 July 09:15 - 10:00 F. ANTINORI Heavy Ions (1/2) 10:15 - 12:00 F. DYDAK Neutrino Physics (1&2/4) Wednesday 31 July  09:15 - 10:00 F. ANTINORI Heavy Ions (2/2) 10:15 - 11:00 F. DYDAK Neutrino Physics (3/4) 11:15 - 12:00 F. DYDAK / F. ANTINORI Discussion Session Thursday 1 August 09:15 - 10:00 T. NAKADA CP Violation (1/4) 10:15 - 11:00 F. DYDAK Neutrino Physics (4/4) 11:15 - 12:00 F. BEDESCHI Experimental test of the SM Tevatron (1/2) Friday 2 August 09:15 - 10:00 T. NAKADA CP Violation (2/4) 10:15 ? 11:00 F. BEDESCHI Experimental test of the SM Tevatron (2/2) 11:15 ? 12:00 F. BEDESCHI / T. NAKADA Di...

  14. SUMMER STUDENT LECTURE PROGRAMME

    CERN Multimedia

    Françoise Benz

    2002-01-01

    Main Auditorium, bldg. 500   DATE TIME LECTURER TITLE Wednesday 3 July 09:15 - 10:00 L. FAYARD, O. ULLALAND Presentation of the Summer Student Programm 10:15 - 12:00 L. MAIANI Introduction to CERN (1&2/2) 14:00 - 15:00 G. Stevenson Radiation Protection (Council Chamber, bldg.503) Thursday 4 July 09:15 - 11:00 F. CLOSE Introduction to Particle Physics for non Physics Students (1&2/4) 11:15 - 12:00 C. JORAM Particle Detectors (1/5) Friday 5 July 09:15 - 11:00 F. CLOSE Introduction to Particle Physics for non Physics Students (3&4/4) 11:15 - 12:00 Discussion Session Monday 8 July 09:15 - 10:00 R. KLEISS Fundamental Concepts of Particle Physics (1/6) 10:15 - 11:00 C. JORAM Particle Detectors (2/5) 11:15 - 12:00 M. FRANKLIN Classic Experiments (1/3) 14:00 - 15:00 M. LINDROOS Isolde 15:30 - 16:30 M. LINDROOS Visit of the Experiment Tuesday 9 july 09:15 - 10:00 R. KLEISS Fundamental Concepts of Particle Physics (2/6) 10:15 - 11:00 C. JORAM Part...

  15. Programmable electronic synthesized capacitance

    Science.gov (United States)

    Kleinberg, Leonard L. (Inventor)

    1987-01-01

    A predetermined and variable synthesized capacitance which may be incorporated into the resonant portion of an electronic oscillator for the purpose of tuning the oscillator comprises a programmable operational amplifier circuit. The operational amplifier circuit has its output connected to its inverting input, in a follower configuration, by a network which is low impedance at the operational frequency of the circuit. The output of the operational amplifier is also connected to the noninverting input by a capacitor. The noninverting input appears as a synthesized capacitance which may be varied with a variation in gain-bandwidth product of the operational amplifier circuit. The gain-bandwidth product may, in turn, be varied with a variation in input set current with a digital to analog converter whose output is varied with a command word. The output impedance of the circuit may also be varied by the output set current. This circuit may provide very small ranges in oscillator frequency with relatively large control voltages unaffected by noise.

  16. FPGAs for software programmers

    CERN Document Server

    Hannig, Frank; Ziener, Daniel

    2016-01-01

    This book makes powerful Field Programmable Gate Array (FPGA) and reconfigurable technology accessible to software engineers by covering different state-of-the-art high-level synthesis approaches (e.g., OpenCL and several C-to-gates compilers). It introduces FPGA technology, its programming model, and how various applications can be implemented on FPGAs without going through low-level hardware design phases. Readers will get a realistic sense for problems that are suited for FPGAs and how to implement them from a software designer’s point of view. The authors demonstrate that FPGAs and their programming model reflect the needs of stream processing problems much better than traditional CPU or GPU architectures, making them well-suited for a wide variety of systems, from embedded systems performing sensor processing to large setups for Big Data number crunching. This book serves as an invaluable tool for software designers and FPGA design engineers who are interested in high design productivity through behavi...

  17. Summer Student Programme

    CERN Multimedia

    2006-01-01

    Date Time Title Speaker 05/07/2006 09:15 - 10:00 Presentation of the Summer Student Programme F. CERUTTI Information on Computing Rules D. HEAGERTY Workshops presentation O. ULLALAND 10:15 - 11:00 Introduction to CERN J. ENGELEN 11:15 Film on CERN 11:00 Introduction to Particle Physics F. CLOSE 11:15 - 12:00 Accelerators (1/5) S. GILARDONI / E. METRAL 12:00 Discussion Session 7/07/2006 09:15 - 11:00 Introduction to Particle Physics F. CLOSE 11:15 - 12:00 Accelerators (2/5) S. GILARDONI / E. METRAL 12:00 Discussion Session 09:15 - 10:00 Accelerators (3/5) S. GILARDONI / E. METRAL 10:15 - 12:00 Detectors (1-2/5) O. ULLALAND 12:00 Discussion Session 11/07/2006 09:15 - 10:00 Accelerators (4/5) S. GILARDONI / E. METRAL 10:15 - 11:00 Detectors (3/5) O. ULLALAND 11:15 - 12:00 Introduction to Nuclear Physics (1/4) P. CHOMAZ P. CHOMAZ 10:15 - 11:00 Accelerators (5/5) S. GILARDONI / E. METRAL 11:15 - 12:00 Detectors (4/5) O. ULLALAND 12:00 Discus...

  18. Summer Student Lecture Programme

    CERN Multimedia

    2004-01-01

    Main Auditorium, bldg. 500 More Information DATE TIME LECTURER TITLE Wednesday 7 July 09:15 - 10:00 L. Fayard, O. Ullaland, D. Heagerty (CERN) Programme Presentation Workshops presentation Information on Computing Rules 10:15 - 11:00 R. Aymar (CERN) Introduction to CERN (1/2) 11:15 - 12:00 J. Engelen (CERN) Introduction to CERN (2/2) 15:00 - 16:30 H. Menzel (CERN) An Introduction to Radiation Protection DATE TIME LECTURER TITLE Thursday 8 july 09:15 - 10:00 L. Di Lella (CERN) Introduction to Particle Physics (1/4) 10:15 - 11:00 L. Di Lella (CERN) Introduction to Particle Physics (2/4) 11:15 - 12:00 P. Chomaz (GANIL / CERN) Fundamental questions in modern nuclear physics: The challenge of exotic nuclei (1/2) DATE TIME LECTURER TITLE Friday 9 July 09:15 - 10:00 L. Di Lella (CERN) Introduction to Particle Physics (3/4) 10:15 - 11:00 P. Chomaz (GANIL / CERN) Fundamental questions in modern nuclear physics: The challenge of exotic nuclei (2/2) 11:15 - 12:00 P....

  19. Management and Communication programme

    CERN Multimedia

    Nathalie Dumeaux

    2005-01-01

    We are pleased to announce the launch of three new courses in the Management and Communication programme: 1.     Managing Time (Open to all Staff Members) The objectives are: To enhance your personal effectiveness through better organisation skills To acquire ways of making the most of your time through improved work habits To reduce stress For the description of this course, please see:  http://humanresources.web.cern.ch/humanresources/external/training/MANCO/P9798/S8E_e.asp 2.     Service Orientation (Open to all Staff Members working in a service-related function) The objectives are: To understand the key elements in an effective client/service provider relationship To develop a client focused approach to providing services For the description of this course, please see:  http://humanresources.web.cern.ch/humanresources/external/training/MANCO/P9798/serv_e.asp 3.   Introduction to Leadership (Open to Staff in Career Paths E & above, including newly appointed supervisors and Sect...

  20. Management and Communication programme

    CERN Multimedia

    Nathalie Dumeaux

    2005-01-01

    We are pleased to announce the launch of three new courses in the Management and Communication programme: 1.     Managing Time (Open to all Staff Members) The objectives are: To enhance your personal effectiveness through better organisation skills To acquire ways of making the most of your time through improved work habits To reduce stress For the description of this course, please see:  http://humanresources.web.cern.ch/humanresources/external/training/MANCO/P9798/S8E_e.asp 2.     Service Orientation (Open to all Staff Members working in a service-related function) The objectives are: To understand the key elements in an effective client/service provider relationship To develop a client focused approach to providing services For the description of this course, please see:  http://humanresources.web.cern.ch/humanresources/external/training/MANCO/P9798/serv_e.asp 3.   Introduction to Leadership (Open to Staff in Career Paths E & above, including newly appointed supervisors and Secti...

  1. Scientific Programme Committee

    Science.gov (United States)

    2013-02-01

    Scientific Programme Committee A. Blondel, University of Geneva A. Cervera, IFIC M. Dracos, IN2P3 I. Efhymiopoulos, CERN J. Ellis, CERN S. Geer, FNAL R. Garoby, CERN M. Goodman, ANL D. Harris, FNAL T. Hasegawa, KEK P. Huber, Virginia Tech. D. Kaplan, IIT Y.D. Kim, Sejong University H. Kirk, BNL Y. Kuno, Osaka University K. Long, Imperial College N.K. Mondal, TIFR J. Morfin, FNAL Y. Mori, Kyoto University K. Nishikawa, KEK V. Palladino, University of Napoli C. Prior, RAL F.J.P. Soler, University of Glasgow J. Strait, FNAL R. Svoboda, University of California Davis F. Terranova, LN Frascati M. Zisman, LBNL Local Organizing Committee E. Benedetto, CERN/NTUA C. Blanchard, University of Geneva A. Blondel, University of Geneva (co-chair) I. Efthymiopoulos, CERN (co-chair) F. Dufour, University of Geneva F. Girard-Madoux, CERN E. Gschwendtner, CERN A. Korzenev, University of Geneva M. Morer-Olafsen, CERN S. Murphy, University of Geneva G. Prior, CERN G. Wikström, University of Geneva E. Wildner, CERN Sponsors EuCARD European Organization for Nuclear Research (CERN) Swiss Institute for Particle Physics (CHIPP) University of Geneva

  2. Automatic TLI recognition system, programmer`s guide

    Energy Technology Data Exchange (ETDEWEB)

    Lassahn, G.D.

    1997-02-01

    This report describes the software of an automatic target recognition system (version 14), from a programmer`s point of view. The intent is to provide information that will help people who wish to modify the software. In separate volumes are a general description of the ATR system, Automatic TLI Recognition System, General Description, and a user`s manual, Automatic TLI Recognition System, User`s Guide. 2 refs.

  3. International programme on the health effects of the Chernobyl accident

    International Nuclear Information System (INIS)

    A memorandum of understanding between the WHO and the Ministry of Health of the USSR was signed in April 1990, calling for the development of a long-term international programme to monitor and mitigate the health effects of the Chernobyl accident. This document reports on progress made to date in terms of technical management and coordination and financial aspects of the programme. It also provides information on future activities and discusses related issues

  4. Country programme frameworks. A special evaluation

    International Nuclear Information System (INIS)

    As a result of the recommendations of the TC Policy Review Seminar held in 1994 the Department of Technical Co-operation initiated Country Programme Framework (CPF) related activities in early 1995. Draft Guidelines for carrying out the CPF process were issued in February 1995. An agenda was propose for carrying gout the CPF process, which also included field missions to those countries where the information on national programmes and priorities available at the Agency was believed to be insufficient. In December 1995 the Evaluation Section was requested by the TC management to evaluate the approach and the progress achieved to date. The findings and conclusions of this evaluation have been formulated after extensive discussions with both in-house staff and external evaluation consultants. They thus represent a distillation of the views expressed by all. 2 figs, 1 tab

  5. Auto-programmable impulse neural circuits

    Science.gov (United States)

    Watula, D.; Meador, J.

    1990-01-01

    Impulse neural networks use pulse trains to communicate neuron activation levels. Impulse neural circuits emulate natural neurons at a more detailed level than that typically employed by contemporary neural network implementation methods. An impulse neural circuit which realizes short term memory dynamics is presented. The operation of that circuit is then characterized in terms of pulse frequency modulated signals. Both fixed and programmable synapse circuits for realizing long term memory are also described. The implementation of a simple and useful unsupervised learning law is then presented. The implementation of a differential Hebbian learning rule for a specific mean-frequency signal interpretation is shown to have a straightforward implementation using digital combinational logic with a variation of a previously developed programmable synapse circuit. This circuit is expected to be exploited for simple and straightforward implementation of future auto-adaptive neural circuits.

  6. Neutron radiography in Indian space programme

    CERN Document Server

    Viswanathan, K

    1999-01-01

    Pyrotechnic devices are indispensable in any space programme to perform such critical operations as ignition, stage separation, solar panel deployment, etc. The nature of design and configuration of different types of pyrotechnic devices, and the type of materials that are put in their construction make the inspection of them with thermal neutrons more favourable than any other non destructive testing methods. Although many types of neutron sources are available for use, generally the radiographic quality/exposure duration and cost of source run in opposite directions even after four decades of research and development. But in the area of space activity, by suitably combining the X-ray and neutron radiographic requirements, the inspection of the components can be made economically viable. This is demonstrated in the Indian space programme by establishing a 15 MeV linear accelerator based neutron generator facility to inspect medium to giant solid propellant boosters by X-ray inspection and all types of critic...

  7. Environmental control programme for the pipeline construction activities - a practical viewing; Programa de controle ambiental das atividades de construcao de dutos. Uma visao pratica

    Energy Technology Data Exchange (ETDEWEB)

    Henrique, Paulo R.P.; Freitas, Eduardo L. [PETROBRAS, Rio de Janeiro, RJ (Brazil)

    1998-07-01

    The environmental Control Plan of the Construction Activities of the Pipeline is a planning tool which sets forth the guidelines and procedures to be adopted by the companies in charge of the construction, so as to manage and minimize the environmental impacts arising from its implementation throughout the several steps of the work. Most of the impacts on the soil, vegetation, wildlife and population are local, on a space and timely basis, and occur mainly during the pipeline implementation. Such impacts may, to a great extend, be mitigated to acceptable levels through the application of the measures provided here under during and after the construction. So, the main purposes of the present Plan are to avoid, minimized, control and litigate potential impacts arising from the construction and operation, and to assure continuous compliance with the applicable environmental legislation. (author)

  8. The determination of pesticide residues and contaminants in vegetables by means of neutron activation analysis. Part of a coordinated programme on nuclear detection and analysis

    International Nuclear Information System (INIS)

    Neutron activation techniques have been applied to study the existence of pesticide residues (As, Br, Hg) and pollutants (Cd, Co, Zn) in local vegetable and fruit samples, polished and unpolished glutinous and non-glutinous milled rice, and fish caught in polluted and unpolluted areas of the Gulf of Thailand. Since the baseline levels of these toxic elements in vegetables, fruits, rice and fish are not known as yet, the results cannot be regarded as conclusive. Furthermore, no significant difference was observed in the concentration of these elements in fish caught in polluted and unpolluted areas. The Gulf of Thailand does not therefore appear to be polluted at present. The substoichiometric isotope dilution technique was successfully applied to mercury determinations, and only to a limited extent to Cd due to shutdown of the TRR-1 reactor

  9. CERN openlab Summer Student Programme

    CERN Multimedia

    2012-01-01

    CERN openlab is currently taking applications for its summer student programme. The closing date for applications is 30 March 2012.   The openlab Summer Student Programme is open for applications from bachelor, master and PhD students in computer science and physics. Successful applicants will spend 8 weeks at CERN, during the period June to September 2012, to work with some of the latest hardware and software technologies. The programme is more than just a summer at CERN: it can lead to follow-on projects at the home institute and may even inspire the students to become entrepreneurs in cutting-edge computing technologies. A series of lectures will be given by experts in various domains of CERN related high-throughput computing. Study tours to external companies and universities as well as to CERN facilities are also part of the programme. Please visit www.cern.ch/openlab-students for more information.

  10. CERN openlab summer student programme

    CERN Multimedia

    2013-01-01

    CERN openlab is currently taking applications for its summer student programme. The closing date for applications is 31 March 2013.   The openlab summer student programme is open for applications from bachelor, master and PhD students in computer science and physics. Successful applicants will spend 9 weeks at CERN, during the period from June to September 2013, working with some of the latest hardware and software technologies. The programme is more than just a summer at CERN: it can lead to follow-on projects at the home institute and may even inspire students to become entrepreneurs in cutting-edge computing technologies. A series of lectures will be given by experts in various domains of CERN-related high-throughput computing. Study tours of external companies and universities as well as of CERN facilities are also part of the programme. Please visit the CERN openlab website for more information.

  11. The internationalisation of postgraduate programmes

    DEFF Research Database (Denmark)

    Fink, Flemming Kobberøe; Andersen, Ole K.; Bak, Thomas;

    2002-01-01

    for the international students are presented and discussed in terms of e.g. the teamwork situation, professional and cultural differences. A student enrolment programme, implemented through the provision of scholarships, jointly paid by government and industry funds is presented...

  12. Field Evaluation of Programmable Thermostats

    Energy Technology Data Exchange (ETDEWEB)

    Sachs, O. [Fraunhofer Center for Sustainable Energy Systems (CSE), Cambridge, MA (United States); Tiefenbeck, V. [Fraunhofer Center for Sustainable Energy Systems (CSE), Cambridge, MA (United States); Duvier, C. [Fraunhofer Center for Sustainable Energy Systems (CSE), Cambridge, MA (United States); Qin, A. [Fraunhofer Center for Sustainable Energy Systems (CSE), Cambridge, MA (United States); Cheney, K. [Fraunhofer Center for Sustainable Energy Systems (CSE), Cambridge, MA (United States); Akers, C. [Fraunhofer Center for Sustainable Energy Systems (CSE), Cambridge, MA (United States); Roth, K. [Fraunhofer Center for Sustainable Energy Systems (CSE), Cambridge, MA (United States)

    2012-12-01

    Prior research suggests that poor programmable thermostats usability may prevent their effective use to save energy. The Fraunhofer team hypothesized that home occupants with high-usability thermostats would be more likely to use them to save energy than people with a basic thermostats. In this report, the team discusses results of a project in which the team monitored and compared programmable thermostats with basic thermostats in an affordable housing apartment complex.

  13. ESF EUROCORES Programmes In Geosciences And Environmental Sciences

    Science.gov (United States)

    Jonckheere, I. G.

    2007-12-01

    through these distinctive research initiatives, to build on the national research efforts and contribute to the capacity building, in relation with typically about 15-20 post-doc positions and/or PhD studentships supported nationally within each Programme. Typical networking activities are topical workshops, open sessions in a larger conference, Programme conference, (summer / winter) schools, exchange visits across projects or programmes. Overall, EUROCORES Programmes are supported by more than 60 national agencies from 30 countries and by the European Science Foundation (ESF) with support by the European Commission, DG Research (Sixth Framework Programme, contract ERAS-CT-2003-980409). In the framework of AGU, a series of present EUROCORES Programmes in the field of Geosciences and Environmental Sciences are presented (e.g., EuroDIVERSITY, EuroDEEP, EUROMARGINS, EuroCLIMATE, and EuroMinScI).

  14. The MERLIN programme: Pt. 1

    International Nuclear Information System (INIS)

    The MERLIN rig at the Northern Research Laboratories, Springfields, was intended to investigate the deformation behaviour of Zircaloy fuel rod cladding under conditions approximating those of a large break Loss of Coolant Accident (LOCA). In this rig, an assembly of electrically heated fuel rod simulators (6x6 cluster) was subjected to a temperature transient simulating that predicted to occur in a LOCA, including the initiation of bottom reflooding at a suitable stage. The main aim of the MERLIN programme was to investigate the extent of sub-channel blockage produced during clad deformation under conditions of high mechanical restraint, in two phase cooling conditions. The programme was to consist of four test bundles, the final two of which would be used for ballooning experiments in which high sub-channel blockage would be produced by a suitable choice of test conditions. A major part of the programme was to provide validation data for reactor accident codes used in the CEGB clad ballooning safety case for Sizewell B. This report, one of a series which describes the programme in detail, is an overview of the MERLIN programme. It provides background, summarises those reports which discuss the programme in detail and draws attention to those areas where useful information has been obtained. (author)

  15. The GAPS Programme with HARPS-N at TNG. VII. Putting exoplanets in the stellar context: magnetic activity and asteroseismology of $\\tau$ Bootis A

    CERN Document Server

    Borsa, F; Rainer, M; Bignamini, A; Maggio, A; Poretti, E; Lanza, A F; Di Mauro, M P; Benatti, S; Biazzo, K; Bonomo, A S; Damasso, M; Esposito, M; Gratton, R; Affer, L; Barbieri, M; Boccato, C; Claudi, R U; Cosentino, R; Covino, E; Desidera, S; Fiorenzano, A F M; Gandolfi, D; Harutyunyan, A; Maldonado, J; Micela, G; Molaro, P; Molinari, E; Pagano, I; Pillitteri, I; Piotto, G; Shkolnik, E; Silvotti, R; Smareglia, R; Southworth, J; Sozzetti, A; Stelzer, B

    2015-01-01

    Aims. We observed the $\\tau$ Boo system with the HARPS-N spectrograph to test a new observational strategy aimed at jointly studying asteroseismology, the planetary orbit, and star-planet magnetic interaction. Methods. We collected high-cadence observations on 11 nearly consecutive nights and for each night averaged the raw FITS files using a dedicated software. In this way we obtained spectra with a high signal-to-noise ratio, used to study the variation of the CaII H&K lines and to have radial velocity values free from stellar oscillations, without losing the oscillations information. We developed a dedicated software to build a new custom mask that we used to refine the radial velocity determination with the HARPS-N pipeline and perform the spectroscopic analysis. Results. We updated the planetary ephemeris and showed the acceleration caused by the stellar binary companion. Our results on the stellar activity variation suggest the presence of a high-latitude plage during the time span of our observatio...

  16. Norwegian mastitis control programme

    Directory of Open Access Journals (Sweden)

    Østerås O

    2009-04-01

    changes in attitude and breeding, eradicating bovine virus diarrhoea virus (BVDV and a better implementation of mastitis prevention programmes.

  17. Radiation protection research and training programme review radiation protection programme 1960-89 synopsis of results 1985-89

    International Nuclear Information System (INIS)

    This document aims to trace the evolution of the CEC radiation protection programme over its 30 years of existence. During this time, research carried out in the framework of the Community programme has made major contributions to the scientific understanding of the action of ionizing radiation and the protection of man and his environment. This information was crucial for developing better radiation protection management for existing and new technologies and for providing the scientific basis for the regulatory activities of the Commission. One important feature of the programme was the success of bringing together scientists from different Member States to cooperate in the various fields of radiation protection and to integrate different areas of radiation protection research into a coherent approach. The structures thus developed within the programme have enabled research in radiation protection to be conducted in a cost-effective manner on behalf of the Member States. This document aims also to give a synopsis of the most important results of the 1985-89 radiation protection programme. This period was characterized by two challenges, the integration of two Member States into Community research and the impact of the Chernobyl accident. The programme has, in spite of reduced funding, continued to provide a high degree of expertise for the Community in the context of the needs in radiation protection. This has been explicity acknowledged in the evaluation of the 1980-89 programmes carried out by an independent panel

  18. The Mice Drawer System (MDS) Tissue Sharing Programme: effect of space conditions on skin metabolic activity and vascularization and potential impact of radiations in mice.

    Science.gov (United States)

    Nusgens, Betty; Lambert, Charles; Liu, Yi; Cancedda, Ranieri; Tavella, Sara; Ruggiu, Alessandra; Colige, Alain

    morphological and immunochemical analysis aim at investigating dermal and epidermal thickness, number and surface of blood vessels (CD31, VW factor, type IV collagen) and lymphatics (D2-40, Lyve), score of acanthosis and papillomatosis, proliferation index (Ki67), epidermal markers of differentiation and FXIIIa positive dendritic cells. Another fragment of skin is used for measuring water content, total collagen content (hydroxyproline) and total proteoglycans content (uronic acid). A differential extraction procedure allows to quantify the newly synthetized collagen and the progressively more heavily cross-linked colla-gen, the pattern of extraction reflecting the turn-over rate of collagen. Quantitative RT-PCR procedure is used to evaluate the expression of extracellular matrix components (fibrillar and FACIT collagens), the enzymes involved in their postranslational modifications (ADAMTS-2, -3, -14, BMP1, prolylhydroxylase, lysyloxydase), the MMPs and their physiologic activators and inhibitors, proteoglycans of the hyalectans family and the SLRP, hyaluronansynthase, ag-grecanases of the ADAMTS family, and vascular markers (CD31, VEGF-A, -C, -D, VEGF-R1, -R2, -R3, PlGF, NRP1 2, SEMA3). A special attention will be paid to the splice variants of VEGF-A. We recently discovered a new splice variant, VEGF111, lacking exons 5, 6 and 7, bio-logically active and resistant to proteolysis that is specifically induced by genotoxic agents such as radiations. Its expression might reflect an impact of radiations during the long stay of the animals in space environment. Additionally, a genome-wide analysis of gene expression will be performed using DNA microarrays (Affimetrix). Partial results of the analyses under way will be presented. http://www.nasa.gov/missionp ages/station/science/experiments/M DS.html

  19. Light-Activated Nuclear Translocation of Adeno-Associated Virus Nanoparticles Using Phytochrome B for Enhanced, Tunable, and Spatially Programmable Gene Delivery.

    Science.gov (United States)

    Gomez, Eric J; Gerhardt, Karl; Judd, Justin; Tabor, Jeffrey J; Suh, Junghae

    2016-01-26

    Gene delivery vectors that are activated by external stimuli may allow improved control over the location and the degree of gene expression in target populations of cells. Light is an attractive stimulus because it does not cross-react with cellular signaling networks, has negligible toxicity, is noninvasive, and can be applied in space and time with unparalleled precision. We used the previously engineered red (R)/far-red (FR) light-switchable protein phytochrome B (PhyB) and its R light dependent interaction partner phytochrome interacting factor 6 (PIF6) from Arabidopsis thaliana to engineer an adeno-associated virus (AAV) platform whose gene delivery efficiency is controlled by light. Upon exposure to R light, AAV engineered to display PIF6 motifs on the capsid bind to PhyB tagged with a nuclear localization sequence (NLS), resulting in significantly increased translocation of viruses into the host cell nucleus and overall gene delivery efficiency. By modulating the ratio of R to FR light, the gene delivery efficiency can be tuned to as little as 35% or over 600% of the unengineered AAV. We also demonstrate spatial control of gene delivery using projected patterns of codelivered R and FR light. Overall, our successful use of light-switchable proteins in virus capsid engineering extends these important optogenetic tools into the adjacent realm of nucleic acid delivery and enables enhanced, tunable, and spatially controllable regulation of viral gene delivery. Our current light-triggered viral gene delivery prototype may be broadly useful for genetic manipulation of cells ex vivo or in vivo in transgenic model organisms, with the ultimate prospect of achieving dose- and site-specific gene expression profiles for either therapeutic (e.g., regenerative medicine) or fundamental discovery research efforts. PMID:26618393

  20. Public relations and political support in area-wide integrated pest management programmes that integrate the sterile insect technique

    International Nuclear Information System (INIS)

    The public relations component of area-wide integrated pest management (AW-IPM) programmes that integrate the sterile insect technique (SIT) has a large impact on programme success. Full-time professionals should direct public relations activities and secure vital political support from governments and community organizations. Good communication among programme staff, and between programme staff and the public, is required to maintain participation and support, and to keep the work goal-oriented even when some programme activities are controversial. The media can be valuable and effective partners by informing the public about the real facts and activities of a programme, especially if this is done in a non-technical and straightforward way. Ongoing research support improves the programme technology, provides technical credibility on contentious issues, and solves operational problems. Programme failure can result from poor public relations and inadequate public support. (author)

  1. Estimating the experimental value of the electromagnetic fine structure constant α-bar 0=1/137.036 using the Leech lattice in conjunction with the monster group and Spher's kissing number in 24 dimensions

    International Nuclear Information System (INIS)

    We start with various observations regarding the kissing number in the 24-dimensional Leech lattice Nτ(24)=196560 as well as the j-function coefficient b=196884 and the minimal dimension in which the monster group can act Dm=196883. Subsequently based on the previous results and earlier numerical experiments, we use a quibic potential to derive a quadratic equationx2+12820x-(Nτ(24)/10)=0where 128=spin 7=(2)7, 10=D(10) and Nτ(24)=196560 are the spin representation, the super string dimension and the Leech kissing number, respectively. It is found that the only positive solution of this equation isx1=137.036=α-bar 0which is the accurate experimental value of inverse of the electromagnetic fine structure constant. This remarkable result is interpreted in terms of the connection between the Moonshine conjecture and string theory as well as the E-infinity relation between the kissing number in 10 dimensions Kτ(10)=336 and the degrees of freedom of Klein's modular space dim Γ(7)=336

  2. Estimating the experimental value of the electromagnetic fine structure constant {alpha}-bar {sub 0}=1/137.036 using the Leech lattice in conjunction with the monster group and Spher's kissing number in 24 dimensions

    Energy Technology Data Exchange (ETDEWEB)

    El Naschie, M.S. [King Abdul Aziz City of Science and Technology, Riyadh (Saudi Arabia)

    2007-04-15

    We start with various observations regarding the kissing number in the 24-dimensional Leech lattice N{sub {tau}}{sup (24)}=196560 as well as the j-function coefficient b=196884 and the minimal dimension in which the monster group can act D{sub m}=196883. Subsequently based on the previous results and earlier numerical experiments, we use a quibic potential to derive a quadratic equationx{sup 2}+12820x-(N{sub {tau}}{sup (24)}/10)=0where 128=spin 7=(2){sup 7}, 10=D{sup (10)} and N{sub {tau}}{sup (24)}=196560 are the spin representation, the super string dimension and the Leech kissing number, respectively. It is found that the only positive solution of this equation isx{sub 1}=137.036={alpha}-bar {sub 0}which is the accurate experimental value of inverse of the electromagnetic fine structure constant. This remarkable result is interpreted in terms of the connection between the Moonshine conjecture and string theory as well as the E-infinity relation between the kissing number in 10 dimensions K{sub {tau}}{sup (10)}=336 and the degrees of freedom of Klein's modular space dim {gamma}(7)=336.

  3. The Hawaii Fruit Fly Area-Wide Pest Management Programme: Influence of a good education and partnerships in a successful programme

    International Nuclear Information System (INIS)

    Full text: Introduction: In 1999, USDA-ARS launched the 'Hawaii Fruit Fly Area-Wide Pest Management (AWPM) Program' as a 5-yr programme to suppress fruit flies below economic thresholds while reducing the use of organophosphate insecticides. The programme involved developing and integrating biologically-based pest technologies into a comprehensive management package that will be economically viable, environmentally sensitive and sustainable. Technologies included: 1) field sanitation, 2) protein bait sprays and/or traps, 3) male annihilation with male lures and attractants, and if needed, 4) augmentative parasitoid releases and 5) sterile insect releases. Many of these technologies were developed by ARS in Hawaii; however, they had never been packaged and transferred to Hawaiian farmers. Education: A critical component of successful area-wide pest management (AWPM) programmes is an organised, coordinated and comprehensive outreach educational programme. The Hawaii area-wide fruit fly pest management (HAW-FLYPM) programme's educational programme, utilised the 'logic model' approach to organise, plan, execute and evaluate farmer and community educational programmes statewide. The logic model approach was an outcome-driven rather than activity-based method that employed a linear sequence that developed relationships between programme inputs, outputs and outcomes. This model was utilised extensively to transfer sustainable, science-based technologies to suppress tephritid fruit fly pests. HAW-FLYPM's educational programme targeted growers and community door yard growers, three teaching curricula aimed at elementary through high school students, and a statewide awareness programme for the public at large. Additional key components of the HAWFLYPM education programme was the development of implementation schedules used to track programme progress, a comprehensive media matrix developed to ensure educational materials met the needs of target audience groups, and a

  4. SKIs evaluation of SKBs RD and D programme 92

    International Nuclear Information System (INIS)

    Section 11 of the Act (1984:3) on Nuclear Activities stipulates that the holder of a licence to own or operate a nuclear power reactor shall ensure that the necessary comprehensive research and development work is conducted in order to safely handle and finally dispose of the nuclear waste produced and to safely decommission and dismantle installation where the nuclear activity is no longer carried out. According to section 12 of the Act on nuclear activities, the reactor owners shall, in consultation with each other, prepare or have prepared a programme for the necessary comprehensive research and development work and the other measures. The programme shall contain an overview of all measures that may be necessary and also specify, in detail, the measures that are intended to be taken within a period of at least six years. The programme shall be submitted to the Government or to the authority designated by the Government for examination and evaluation. According to section 22 of the ordinance on nuclear activities, the Swedish Nuclear Power Inspectorate (SKI) shall ensure that the research and development work which the reactor owners are responsible for undertaking according to sections 11 and 12 of the act of nuclear activities, is actually carried out. SKIs premise for evaluating the programme has been to examine it as an integrated R and D programme, which essentially focusses on structure, strategy and planning in order to effectively realize the defined goals of the programme, i.e. finding a safe, final solution to the disposal of spent nuclear fuel. Keeping to the time-schedule should not be the controlling factor in carrying out the research and development programme. The essential objective is to attain the goal without jeopardizing quality. SKIs examination has been documented in the form of the following: summary and conclusions, evaluation report, report of comments by reviewing bodies, and consultants reports. SKIs statement to the Government has been

  5. A reappraisal of the virtues of private sector employment programmes

    DEFF Research Database (Denmark)

    Jensen, Peter; Graversen, Brian Krogh

    In this paper, we evaluate the employment effects of Danish active labour market programmes aimed at welfare benefit recipients. We estimate an econometric model with treatment effects and discrete outcomes and we allow the responses to treatment to vary among observationally identical persons....... The empirical analysis is based on a register-based dataset that gives infor-mation on participation in labour market programmes and subsequent employment. Using a latent variable model, we estimate commonly defined treatment effects, and in particular, the distribution of treatment effects. We do not find any...... significant mean effects of participation in private sector employment programmes compared to participation in other programmes, but we find evidence of heterogeneity in the treatment effects....

  6. Nuclear power training programmes in Spain

    International Nuclear Information System (INIS)

    The introduction of nuclear power in Spain is developing very rapidly. At present 1.1GW(e) are installed in Spain and this is expected to increase to 8GW(e) in 1980 and to 28GW(e) in 1990. Spanish industry and technology are also rapidly increasing their participation in building nuclear stations, in manufacturing the necessary components and in the activities related to the nuclear fuel cycle. All of this requires properly trained personnel, which is estimated to become approximately 1200 high-level technicians, 1100 medium-level technicians and 1500 technical assistants by 1980. This personnel is trained: (a) in engineering schools; (b) in the Nuclear Studies Institute; (c) in the electric companies with nuclear programmes. The majority of the high-level engineering schools in the country include physics and basic nuclear technology courses in their programmes. Some of them have an experimental low-power nuclear reactor. The Nuclear Studies Institute is an official organism dependent on the Nuclear Energy Commission and responsible, among other subjects, for training personnel for the peaceful use and development of nuclear energy in the country. The electric companies also participate in training personnel for future nuclear stations and they plan to have advanced simulators of PWR and BWR type stations for operator training. The report deals with the personnel requirement forecasts and describes the training programmes. (author)

  7. Training in radiological protection for nuclear programmes

    International Nuclear Information System (INIS)

    Many Member States are developing or already have developed their own national training programmes. The IAEA is actively involved in promoting training in radiological protection for nuclear programmes. The various types of training are fully discussed, with suggested curricula. An earlier report was published as Technical Reports Series No.31 in 1964. In 1973, new and additional information was received from Member States which is reflected in the present report. Training programmes are classified, according to those requiring training: specialists; persons whose work is closely related to radiological protection (administrators, public health officers and industrial health personnel, safety inspectors and engineers in nuclear installations, public service personnel); persons working with radiation; and the general public. Forms, scope and duration of training are discussed. Different types of training programmes are currently required for training of medical doctors (those providing medical surveillance for radiation workers and others dealing with public health aspects of radiation hazards), for technical supervisors, radiologists, and qualified workers in nuclear medicine, technological staff, administrators, persons working with radiation, and public service personnel. Standard curricula and desirable experiments and exercises are discussed. The organization of training together with the facilities, equipment and teaching staff required are considered, as is follow-up training. Annexes 1 to 4 give examples of training curricula and training courses available in various countries, a suggested syllabus for training of technical supervisors, and a bibliography consisting of 210 references dealing with general topics, nuclear radiation physics, radiochemistry and radiation chemistry, radiation biology and biophysics, dosimetry and health physics and radiation protection, medical aspects and toxicology, and environmental aspects

  8. NDA National Graduate Programme 'nucleargraduates'

    International Nuclear Information System (INIS)

    The aim of this paper is to outline the NDA National Graduate Programme (nuclear graduates). The NDA has a remit under the Energy Act (2004) 'to maintain and develop the skills for decommissioning and nuclear clean-up'. Although current research is now being reviewed, there is significant evidence to suggest that the age profile in the Site Licence Companies is skewed towards older workers and there is likely to be a skill shortage in 3-5 years. As nuclear clean-up is a national issue; skill shortages also become a national issue in a very real sense. In addition, evidence suggests that the industry needs to be constantly challenged in order to achieve its targets for decommissioning. The NDA has a unique position under the Act. It is both a strategic overseer and direct employer. To this end the 'National Graduate Programme' is aligned to both the NDA's previous succession plans and the needs of the industry. Industry needs leadership that challenges the status quo and moves the UK nuclear industry to become best in class; Industry needs a dedicated to programme to address skills shortages and difficult to recruit areas such as, but not exclusively, estimators, schedulers, contract managers, site engineers, decommissioning technicians, safety monitors; The NDA has indicated a 'commercial and politically savvy' cohort is required to meet its own internal challenges and to ensure sustainability in its own workforce, and to be sensitive to the needs of customers and suppliers alike; Need to create a more diversified workforce in the nuclear industry and also plan for new skills evolving from research and development breakthroughs; Need to ensure that Tier 1, 2, 3 and 4 contractors invest in the leadership and skills for the future. World Class - delivery will be benchmarked against UK based multinational companies who operate in a global graduate attraction and development marketplace. The graduates targeted will be from leading institutions and will have a blend of

  9. Mechanisms and clinical significance of quality of final kissing balloon inflation in patients with true bifurcation lesions treated by crush stenting technique

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jun-jie; CHEN Shao-liang; YE Fei; YANG Song; KAN Jing; LIU Yue-qiang; ZHOU Yong; SUN Xue-wen; ZHANG Ai-ping; WANG Xin; CHEN Jack

    2009-01-01

    Background The mechanisms responsible for the occurrence of a kissing unsatisfied (KUS) result after classical crush stenting remain unclear. The present study aimed at analyzing the mechanisms and clinical significance of KUS. Methods Two hundred and thirteen patients with true bifurcation lesions treated with classical crush stenting and final kissing balloon inflation (FKBI) were assigned to upper, middle, and lower groups according to the position of the side branch re-wiring assessed by visual estimation, quantitative coronary analysis (QCA) and intravascular ultrasound (IVUS). Angiographic follow-up was indexed at 12 months.Results The upper group was characterized by a larger bifurcation angle of 55.53°±95.25° (P=0.030) and a longer procedural time (42.43±93.92) minutes (P=0.015). The overall rate of KUS by visual estimation was 10.48%, with 5.4% in the upper group, 3.9% in middle group, and 36.1% in lower group (P <0.001). For the diagnosis of KUS, visual inspection demonstrated a good correlation with both QCA and IVUS. Smaller stent diameter was the main reason for KUS in the upper group, while extra-stent side wire location, or re-wire in a low position was the main mechanism attributed to KUS in the lower group. The Lower group had more restenosis, with most restenotic lesions at a lower position of the side branch ostium. KUS (HR 1.652, 95% Cl 1.332-2.088, P <0.001) and re-wiring position (HR 2.341, 95% Cl 1.780-4.329, P <0.001) were two independent predictors of side branch restenosis. Re-wiring position (OR 0.458, 95%Cl 0.336-0.874, P=0.001) and side stent expansion (OR 3.122, 95%Cl 2.883-5.061, P=0.014) were factors predicting the findings of KUS.Conclusions Side wire outside side stents resulted in more KUS and restenosis. Different restenotic lesion types reflected individual mechanisms contributing to the development of plaque proliferation.

  10. Evaluation of the FWF Doctoral Programme (DK Programme)

    OpenAIRE

    Ecker, Brigitte; Kottmann, Andrea; Meyer, Susanne; Brandl, Bianca

    2014-01-01

    In the winter term 2013 a total of 27,634 doctoral students were enrolled at Austrian universities and a total of 2,165 students obtained a doctoral degree; thereof 204 (9.4%) students graduated in a PhD Programme. In total 7,158 doctoral students were employed at Austrian universities in 2012. These numbers include those doctoral students with temporary positions who were funded by competitive means, as provided by the funding programmes of the FWF. In total the FWF as the most important fun...

  11. Europe's space photovoltaics programme

    Science.gov (United States)

    Bogus, Klaus P.

    1994-01-01

    The current space PV (photovoltaic) technology development program of ESA is described. The program is closely coupled to the European space mission scenario for the next 10 year period and has as its main objective to make the most effective use of the limited resources available for technology in the present economical climate. This requires a well-balanced approach between concentration on very few options and keeping the competition alive if more than one promising technology exists. The paper describes ESA's main activities in the areas of solar array technology, solar cell technology, solar cell assembly technology, and special test and verification activities including the in-orbit demonstration of new technologies.

  12. Programmable automation systems in PSA

    International Nuclear Information System (INIS)

    The Finnish safety authority (STUK) requires plant specific PSAs, and quantitative safety goals are set on different levels. The reliability analysis is more problematic when critical safety functions are realized by applying programmable automation systems. Conventional modeling techniques do not necessarily apply to the analysis of these systems, and the quantification seems to be impossible. However, it is important to analyze contribution of programmable automation systems to the plant safety and PSA is the only method with system analytical view over the safety. This report discusses the applicability of PSA methodology (fault tree analyses, failure modes and effects analyses) in the analysis of programmable automation systems. The problem of how to decompose programmable automation systems for reliability modeling purposes is discussed. In addition to the qualitative analysis and structural reliability modeling issues, the possibility to evaluate failure probabilities of programmable automation systems is considered. One solution to the quantification issue is the use of expert judgements, and the principles to apply expert judgements is discussed in the paper. A framework to apply expert judgements is outlined. Further, the impacts of subjective estimates on the interpretation of PSA results are discussed. (orig.) (13 refs.)

  13. Comparison of programme MOBY-DICK with nodal programmes on benchmark problems

    International Nuclear Information System (INIS)

    In this paper we compare programme MOBY-DICK (which is diffusion difference programme) with nodal programmes no two-dimensional hexagonal benchmark problems for the VVER-type reactors (published by Chao and Shatilla). Nodal results are partly from one's own programme NODRAM and partly from literature. There is presented dependence on lattice pitch by difference programme and influence of boundary conditions (Author)

  14. Attendance in cancer screening programmes in Italy

    Directory of Open Access Journals (Sweden)

    Grazia Grazzini

    2008-06-01

    Full Text Available

    Background: The European Community recommends mammography, cervical and colorectal cancer screening programmes. In Italy, cancer screening programmes have been included in the Basic Healthcare Parameters (Livelli Essenziali di Assistenza since 2001. Full national coverage of a population-based organized screening programme has been planned for in Italy and is being implemented. Since 2005, the Ministry of Health - Department of Prevention has formally charged The National Centre for Screening Monitoring (Osservatorio Nazionale Screening –ONS- with monitoring and promoting screening programmes nationwide. Participation of target populations is a key indicator of the impact and efficacy of a screening programme in reducing cancer mortality.

    Methods: Attendance of invitees is one of the indicators calculated every year in the quality control of Italian screening programmes. Data collection is organized by means of a structured questionnaire, sent by ONS to the referent for data collection in each Region, who then returns the completed questionnaires to the Regional Centre. Questionnaires are then sent to the National Centre. Logical and epidemiologic checks are performed at both levels. Every year ONS publishes reports on the results of the surveys. A feasibility study for a National data warehouse based on individual records is in progress. The national survey “Multiscopo sulle famiglie” and the Passi Study (Progetti delle Aziende Sanitarie per la Salute in Italia provided additional information regarding spontaneous preventive health care activities in the Italian population.

    Results: Mammography screening: In 2006, 78.2% of Italian women aged 50-69 lived in areas where organised screening was in place (theoretical extension, however, the distribution of the screening activity is not uniform (higher in Northern/Central Italy compared with Southern

  15. Country programme review. Ethiopia

    International Nuclear Information System (INIS)

    This document reviews the current nuclear program in Ethiopia, identifying the peaceful uses of nuclear technology in the country and possible future technical cooperation activities. Separate brief sections deal with food and agriculture; human health; water and geothermal resources; industrial applications and instrumentation; radiation protection; higher education; programming, coordination and development

  16. QA programme documentation

    International Nuclear Information System (INIS)

    The present paper deals with the following topics: The need for a documented Q.A. program; Establishing a Q.A. program; Q.A. activities; Fundamental policies; Q.A. policies; Quality objectives Q.A. manual. (orig./RW)

  17. Country programme review. Guatemala

    International Nuclear Information System (INIS)

    This document reviews the current nuclear program in Guatemala, identifying the peaceful uses of nuclear technology in the country and possible future technical co-operation activities. Separate brief sections deal with food and agriculture; human health; radiation protection; industrial applications and hydrology; nuclear analytical techniques; nuclear instrumentation and nuclear information

  18. Country programme review. Mongolia

    International Nuclear Information System (INIS)

    This document reviews the current nuclear program in Mongolia, identifying the peaceful uses of nuclear technology in the country and possible future technical co-operation activities. Separate brief sections deal with food and agriculture; mineral resources; nuclear chemistry, nuclear physics and instrumentation; human health; radiation protection; water resources and nuclear energy. 1 tab

  19. Radon programmes and health marketing.

    Science.gov (United States)

    Fojtikova, Ivana; Rovenska, Katerina

    2011-05-01

    Being aware of negative health effects of radon exposure, many countries aim for the reduction of the radon exposure of their population. The Czech radon programme was commenced >20 y ago. Since then experts have gathered a lot of knowledge, necessary legislation has been enacted, tens of thousands of inhabitants have been offered free measurement and subsidy for the mitigation. Despite the effort, the effectiveness of the radon programme seems to be poor. Newly built houses still exhibit elevated radon concentrations and the number of houses mitigated is very low. Is it possible to enhance the effectivity of radon programme while keeping it on a voluntary basis? One possible way is to employ health marketing that draws together traditional marketing theories and science-based strategies to prevention. The potential of using marketing principles in communication and delivery of radon information will be discussed. PMID:21498864

  20. Energy Management Programmes for Industry

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-09-05

    The IEA Policy Pathway publications provide details on how to implement specific recommendations drawn from the IEA 25 Energy Efficiency Policy Recommendations. This Policy Pathway, jointly produced by the International Energy Agency and the Institute for Industrial Productivity, develops the critical steps for policy makers implementing energy management programmes for industry. Optimising energy use in industry is essential to improve industrial competitiveness and achieve wider societal goals such as energy security, economic recovery and development, climate change mitigation and environmental protection. While there is significant potential to decrease energy consumption in this sector, opportunities to improve energy efficiency are still under-exploited. Energy management programmes have shown to be instrumental in addressing many of the barriers that inhibit wide-scale uptake of energy management in industry. The Policy Pathway builds on lessons learned from country experiences and provides actionable guidance on how to plan and design, implement, evaluate and monitor energy management programmes for industry.

  1. Development of Seasonal Storage in Denmark:Status of Storage Programme 1997-2000

    OpenAIRE

    Heller, Alfred

    2000-01-01

    National survey on seasonal (thermal, large-scale) storage activities in Denmark. A storage programme under the Danish Energy Agency. Programme background, objectives, activities, projects and results.Technologies presented: Pit water storage, gravel water storage with pipe heat exchangers, lining materials for pit and lid designs.

  2. Report of the Director-General on the Long-Term Programme in the Field of Hydrology.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). General Conference.

    The report describes the principal orientations of the International Hydrological Programme, as well as the procedures suggested for its execution. The origin and justification of the programme are presented. The objectives of the 1975 programme are stated and the contents, which include the activities, themes, application of new techniques in…

  3. Improving Latino Children's Early Language and Literacy Development: Key Features of Early Childhood Education within Family Literacy Programmes

    Science.gov (United States)

    Jung, Youngok; Zuniga, Stephen; Howes, Carollee; Jeon, Hyun-Joo; Parrish, Deborah; Quick, Heather; Manship, Karen; Hauser, Alison

    2016-01-01

    Noting the lack of research on how early childhood education (ECE) programmes within family literacy programmes influence Latino children's early language and literacy development, this study examined key features of ECE programmes, specifically teacher-child interactions and child engagement in language and literacy activities and how these…

  4. Measuring business continuity programmes in large organisations.

    Science.gov (United States)

    Green, Christopher

    2014-01-01

    In the field of business continuity management, organisations commit sums of money (often very large sums) to develop and maintain their continuity capability. Despite this, there is almost no measurement of whether this expense offers value for money, or whether it is targeted in the right areas. This paper will explain some methods of measuring components of a business continuity programme. The important outputs from this measurement activity are to demonstrate that an organisation's continuity capability is improving over time, and to identify areas of weakness that should be targeted during future work. PMID:25193458

  5. Main Results of the OECD BEMUSE Programme

    International Nuclear Information System (INIS)

    The BEMUSE (Best Estimate Methods Uncertainty and Sensitivity Evaluation) Programme promoted by the Working Group on Analysis and Management of Accidents (WGAMA) and endorsed by the Committee on the Safety of Nuclear Installations (CSNI) represents an important step towards reliable application of high-quality best-estimate and uncertainty and sensitivity evaluation methods. The methods used in this activity are considered to be mature for application, including licensing processes. Skill, experience and knowledge of the users about the applied suitable computer code as well as the used uncertainty method are important for the quality of the results. (authors)

  6. Measuring business continuity programmes in large organisations.

    Science.gov (United States)

    Green, Christopher

    2014-01-01

    In the field of business continuity management, organisations commit sums of money (often very large sums) to develop and maintain their continuity capability. Despite this, there is almost no measurement of whether this expense offers value for money, or whether it is targeted in the right areas. This paper will explain some methods of measuring components of a business continuity programme. The important outputs from this measurement activity are to demonstrate that an organisation's continuity capability is improving over time, and to identify areas of weakness that should be targeted during future work.

  7. British Energy Operating Experience Programme

    International Nuclear Information System (INIS)

    British Energy is the major nuclear generator in the U.K. It has a market share varying between 22% and 25% of the total U.K. generation. The fleet of power stations operated by British Energy consists of one 1250 MWe Pressurised Water Reactor, six Advanced Gas Cooled reactor sites, each with two reactor units of 660 MWe, and one coal fired site with four units of 500 Mwe. In early 1999 British Energy set a strategic goal, for all its reactor units, to achieve 'World Class Performance through Cost leadership' by the end of year 2004. This would be measured against the applicable Upper Quartile performance indicators of the World Association of Nuclear Operators (WANO). Against this strategic goal six fundamental objectives were identified, one of which was to define, deploy and measure the effectiveness of a world class Operating Experience programme. British Energy has clearly re-defined its Operating Experience programme and, recognised the value of learning from Operating Experience. Commitment to the programme, and communicating the value of an effective OE programme is being clearly demonstrated by all managers throughout the organisation. Making the information easily accessible at the workplace has been achieved via the British Energy intranet, the harder step is to ensure OE is consulted before commencing an assigned task or plant evolution. Early signs of this are encouraging, but a continuous sustained effort will be required for probably the next two years. The full deployment of the OE programme is scheduled to be complete by 2004. There will however be a redefined programme identified by then to incorporate the lessons learnt and to ensure the programme is aligned with the business as it evolves. An analysis of event root causes and precursors since May 2001 will be undertaken in June 2002. These will be compared with data from previous years to ascertain the effect on the number of recurring events. The critical question, 'has this prevented recurring

  8. Algorithmique et langages de programmation

    OpenAIRE

    Arsac, Jacques

    1991-01-01

    Dans les débuts de l'informatique, un cours de programmation consistait essentiellement en une description des organigrammes, comme représentation graphique de la structure d'un programme (tellement embrouillée qu'il fallait bien en passer par là), et la liste des instructions d'un langage : les constantes entières s'écrivent avec des chiffres sans point décimal ni partie exposant, un identificateur... l'instruction LIRE, etc. Pour le reste, l'apprenti programmeur devait se débrouiller tout s...

  9. Accelerator Neutrino Programme at FERMILAB

    International Nuclear Information System (INIS)

    The accelerator neutrino programme in the USA consists primarily of the Fermilab neutrino programme. Currently, Fermilab operates two neutrino beamlines, the Booster neutrino beamline and the NuMI neutrino beamline and is the planning stages for a third neutrino beam to send neutrinos to DUSEL. The experiments in the Booster neutrino beamline are miniBooNE, SciBooNE and in the future microBooNE, whereas in the NuMI beamline we have MINOS, ArgoNut, MINERVA and coming soon NOA. The major experiment in the beamline to DUSEL will be LBNE. (author)

  10. The ESO Observing Programmes Committee

    Science.gov (United States)

    Westerlund, B. E.

    1982-06-01

    Since 1978 the ESO Observing Programmes Committee (OPC) has "the function to inspect and rank the proposals made for observing programmes at La Silla, and thereby to advise the Director General on the distribution of observing time". The members (one from each member country) and their alternates are nominated by the respective national committees for five-year terms (not immediately renewable). The terms are staggered so that each year one or two persons are replaced. The Chairman is appointed annually by the Council. He is invited to attend Council meetings and to report to its members.

  11. Real options valuation of fusion energy R and D programme

    International Nuclear Information System (INIS)

    This paper aims to perform a real options valuation of fusion energy R and D programme. Strategic value of thermonuclear fusion technology is estimated here based on the expected cash flows from construction and operation of fusion power plants and the real options value arising due to managerial flexibility and the underlying uncertainty. First, a basic investment option model of Black-Scholes type is being considered. Then, a fuzzy compound real R and D option model is elaborated, which reflects in a better way the multi-stage nature of the programme and takes into account the imprecision of information as one of the components of the overall programme uncertainty. Two different strategies are compared: 'Baseline' corresponding to a relatively moderate pace of fusion research, development, demonstration and deployment activities vs. 'Accelerated' strategy, which assumes a rapid demonstration and massive deployment of fusion. The conclusions are drawn from the model calculations regarding the strategic value of fusion energy R and D and the advantages of accelerated development path. - Research highlights: → Real options analysis of fusion R and D, demonstration and deployment (RDDD) programme. → ENPV of fusion RDDD programme is calculated using stochastic probabilistic simulation. → Fusion RDDD programme exhibits substantial positive real options value: Euro 245 billion. → Fuzzy compound real option valuation method provides more robust results.

  12. The Finnish research programme on climate change. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Roos, J. [ed.

    1996-12-31

    This is the final report of the Finnish Research Programme on Climate Change (SILMU). This report includes the final results and conclusions made by the individual research groups. The aim of this report is to lay out the research work, and to present the main results and conclusions obtained during the six-year work. The Finnish Research Programme on Climate Change (SILMU) was a multidisciplinary national research programme on climate and global change. The principal goals of SILMU were: (1) to increase our knowledge on climate change, its causes, mechanisms and consequences, (2) to strengthen the research on climate change in Finland, (3) to increase the participation of Finnish researchers in international research programmes, and (4) to prepare and disseminate information for policy makers on adaptation and mitigation. The key areas of the research were: (1) quantification of the greenhouse effect and the magnitude of anticipated climatic changes,(2) assessment of the effects of changing climate on ecosystems, and (3) development of mitigation and adaptation strategies. The research programme started in June 1990, and it comprised more than 80 individual research projects, ranging from atmospheric chemistry to economics. There were approximately two hundred scientists working within the programme in seven universities and eleven research institutions. The research activities that comprise SILMU were grouped into four interdisciplinary subprogrammes: atmosphere, waters, terrestrial ecosystems and integration and human interactions

  13. Implementation evaluation of the business process services incentive programme

    Directory of Open Access Journals (Sweden)

    Nonceba Mashalaba

    2015-07-01

    Full Text Available The paper describes the implementation evaluation of the business process services (BPS incentive programme undertaken by the Department of Trade and Industry (the dti and the Department of Performance Monitoring and Evaluation (DPME as part of the 2012/2013 National Evaluation Plan. The evaluation started on 31 October 2012 and the final report was approved on 17 May 2013. The evaluation covers the period from the inception of the programme in January 2011 to December 2012. The BPS incentive programme was implemented to stimulate the business process sector which contributes to economic growth largely through employment creation. The main objectives of the programme are to attract investment and create employment opportunities through offshoring activities. Twenty-six indicators across the five Development Assistance Community (DAC evaluation criteria were developed. A multi-method approach was undertaken to collect data for each of the indicators. The key findings relate to the operation of the programme and a number of suggestions were made as to how to strengthen it. Overall 3807 jobs have been created through the BPS programme during the period under review. Estimated total investment provided by firms is approximately R2.7 billion. Amongst others, the study recommended that the design of the programme be reviewed and extended, potentially to a five-year period in order to maintain the competitiveness of South Africa as a business process off shoring destination. It is essential to address the skills shortage to ensure the growth and sustainability of the South African BPS industry and finally the uptake of the incentive programme.

  14. Neurokinin B-related Peptide Suppresses the Expression of GnRH I, Kiss2 and tac3 in the Brain of Mature Female Nile tilapia Oreochromis niloticus.

    Science.gov (United States)

    Jin, Ye Hwa; Park, Jin Woo; Kim, Jung-Hyun; Kwon, Joon Yeong

    2016-03-01

    Neurokinin B (NKB) and neurokinin B related peptide (NKBRP) belong to tachykinin peptide family. Theyact as a neurotransmitter and/or neuromodulator. Mutation of NKB and/or its cognate receptor, NK3R resulted in hypogonadotropic hypogonadism in mammals, implying a strong involvement of NKB/NK3R system in controlling mammalian reproduction. Teleosts possess NKBRP as well as NKB, but their roles in fish reproduction need to be clarified. In this study, NKB and NKBRP coding gene (tac3) was cloned from Nile tilapia and sequenced. Based on the sequence, Nile tilapia NKB and NKBRP peptide were synthesized and their biological potencies were tested in vitro pituitary culture. The synthetic NKBRP showed direct inhibitory effect on the expression of GTH subunits at the pituitary level. This inhibitory effect was confirmed in vivo by means of intraperitoneal (ip) injection of synthetic NKB and NKBRP to mature female tilapia (20 pmol/g body weight [BW]). Both NKB and NKBRP had no effect on the plasma level of sex steroids, E2 and 11-KT. However, NKBRP caused declines of expression level of GnRH I, Kiss2 and tac3 mRNAs in the brain while NKB seemed to have no distinct effect. These results indicate some inhibitory roles of NKBRP in reproduction of mature female Nile tilapia, although their exact functions are not clear at the moment. PMID:27294210

  15. The NASA Exobiology Programme

    Science.gov (United States)

    DesMarais, David J.; Chang, Sherwood (Technical Monitor)

    1996-01-01

    NASA will indeed conduct a more active search for life beyond Earth. Research on the Martian meteorites will be augmented by $2 million to be contributed equally by NASA and NSF (National Science Foundation). The science strategy for the NASA Mars Surveyor Program now places a much higher priority on the search for life, particularly fossil evidence. This program features two launches per opportunity (every two years, starting this November). The focus on Exobiology emphasizes high resolution multispectral orbital mapping to locate key aqueous sedimentary minerals, the exploration of ancient terrains by capable rovers, and the need for multiple sample return missions. Additional information is contained within the original extended abstract.

  16. National STDs control programme.

    Science.gov (United States)

    Bhargava, N C

    1989-04-01

    In 1947 the Bhore Committee recommended that sexually transmitted diseases should be dealt with by special organizations within the provinces, but the institutions were not adequate, and there was no coordinated plan. Before the 1st 5-year plan, there were 50 state-administered sexually transmitted disease clinics in India. During the 1st 5-year plan, facilities were upgraded, the central government took over certain aspects of the program, and the World Health Organization Venereal Disease team submitted a report on control of venereal diseases in India. By the end of the 5th 5-year plan, the government had set up another 187 clinics. Until the 6th 5-year plan, the central government supplied material, equipment, and drugs to the clinics, but the operating costs were borne by the states. During the 6th 5-year plan, the central government took over all aspects of the program. It is estimated that 20 million Indians suffer from venereal disease. With World Health Organization assistance, group educational activities in sexually transmitted diseases are being organized in different parts of the country, so that all personnel will be better equipped to treat patients. Group educational activities for treatment of yaws are also being organized for paramedical personnel who will have to deal with yaws in tribal areas. The UN Childrens Fund is also providing funds for communication and social mobilization against venereal diseases. PMID:12282050

  17. Uptake of Space Technologies - An Educational Programme

    Science.gov (United States)

    Bacai, Hina; Zolotikova, Svetlana; Young, Mandy; Cowsill, Rhys; Wells, Alan; Monks, Paul; Archibald, Alexandra; Smith, Teresa

    2013-04-01

    Earth Observation data and remote sensing technologies have been maturing into useful tools that can be utilised by local authorities and businesses to aid in activates such as monitoring climate change trends and managing agricultural land and water uses. The European Earth observation programme Copernicus, previously known as GMES (Global Monitoring for Environment and Security), provides the means to collect and process multi-source EO and environmental data that supports policy developments at the European level. At the regional and local level, the Copernicus programme has been initiated through Regional Contact Office (RCO), which provide knowledge, training, and access to expertise both locally and at a European level through the network of RCOs established across Europe in the DORIS_Net (Downstream Observatory organised by Regions active In Space - Network) project (Grant Agreement No. 262789 Coordination and support action (Coordinating) FP7 SPA.2010.1.1-07 "Fostering downstream activities and links with regions"). In the East Midlands UK RCO, educational and training workshops and modules have been organised to highlight the wider range of tools and application available to businesses and local authorities in the region. Engagement with businesses and LRA highlighted the need to have a tiered system of training to build awareness prior to investigating innovative solutions and space technology uses for societal benefits. In this paper we outline education and training programmes which have been developed at G-STEP (GMES - Science and Technology Education Partnership), University of Leicester, UK to open up the Copernicus programme through the Regional Contact Office to downstream users such as local businesses and LRAs. Innovative methods to introduce the operational uses of Space technologies in real cases through e-learning modules and web-based tools will be described and examples of good practice for educational training in these sectors will be

  18. 3D Printed Programmable Release Capsules.

    Science.gov (United States)

    Gupta, Maneesh K; Meng, Fanben; Johnson, Blake N; Kong, Yong Lin; Tian, Limei; Yeh, Yao-Wen; Masters, Nina; Singamaneni, Srikanth; McAlpine, Michael C

    2015-08-12

    The development of methods for achieving precise spatiotemporal control over chemical and biomolecular gradients could enable significant advances in areas such as synthetic tissue engineering, biotic-abiotic interfaces, and bionanotechnology. Living organisms guide tissue development through highly orchestrated gradients of biomolecules that direct cell growth, migration, and differentiation. While numerous methods have been developed to manipulate and implement biomolecular gradients, integrating gradients into multiplexed, three-dimensional (3D) matrices remains a critical challenge. Here we present a method to 3D print stimuli-responsive core/shell capsules for programmable release of multiplexed gradients within hydrogel matrices. These capsules are composed of an aqueous core, which can be formulated to maintain the activity of payload biomolecules, and a poly(lactic-co-glycolic) acid (PLGA, an FDA approved polymer) shell. Importantly, the shell can be loaded with plasmonic gold nanorods (AuNRs), which permits selective rupturing of the capsule when irradiated with a laser wavelength specifically determined by the lengths of the nanorods. This precise control over space, time, and selectivity allows for the ability to pattern 2D and 3D multiplexed arrays of enzyme-loaded capsules along with tunable laser-triggered rupture and release of active enzymes into a hydrogel ambient. The advantages of this 3D printing-based method include (1) highly monodisperse capsules, (2) efficient encapsulation of biomolecular payloads, (3) precise spatial patterning of capsule arrays, (4) "on the fly" programmable reconfiguration of gradients, and (5) versatility for incorporation in hierarchical architectures. Indeed, 3D printing of programmable release capsules may represent a powerful new tool to enable spatiotemporal control over biomolecular gradients. PMID:26042472

  19. TECHNICAL TRAINING PROGRAMME

    CERN Multimedia

    Davide Vitè

    2002-01-01

    CLEAN-2002: Working in a Cleanroom A new, free of charge, half-day seminar is offered in the context of Technical Training for the LHC, for personnel working or managing activities in a cleanroom (for example physicists, engineers and technicians working at or visiting the laboratory). CLEAN-2002 is aimed at raising awareness about good working practices in a cleanroom, and at providing practical examples, analysis tools, and documentation. Specific problems put forward beforehand by attendees will also be addressed, if possible. More information and registration is available HERE The next session, in English, will be on 24.4 (afternoon). Other sessions, in French and English, will be offered following demand. Organiser: Davide Vitè / HR-TD / 75141 Davide.Vite@cern.ch

  20. Population education country programmes.

    Science.gov (United States)

    1980-12-01

    Population education country programs in the countries of India, Malaysia, Nepal, the Philippines, and Sri Lanka are reviewed. In India the machinery is beginning to roll for the nationwide implementation of a 3-year national population education project. A variety of strategies will be used at the national and state levels using existing facilities and infrastructure for implementing various aspects of the program. Recommendations and proposed project activities arrived at during 2 workshop/training programs are outlined. The Malaysian population education program recently developed a working draft of the scope, content, and objectives of population education at the primary and lower and upper secondary levels. This working draft is being pretested among teachers and curriculum developers, and, once revised, it will serve as the overall guiding framework for those responsible for preparing curriculum and instructional materials on population education. The population education program in Nepal will be implemented by 3 units: Curriculum, Textbook, Supervision, and Development Center; Tribhuvan University; and Division of Adult Education. The longterm objective is to institutionalize population education in the formal and nonformal education programs including the university. The Population Education Program of the Philippines has prepared a reader in Filipino for grade 3 pupils. Population education in the country has been promoted to a lesser degree in private than in public schools. the Institutional Development Program of the Population Center Foundation conducted a Summer Institute in Instructional Product Development for the primary purpose of institutionalizing population in the social science curriculum at the tertiary level. The population education program of Sri Lanka will undergo a revival in the recently approved 2-year project agreement between Sri Lanka's government and the United Nations Fund for Population Activities.

  1. Fusion technology programme

    International Nuclear Information System (INIS)

    In the water cooled INTOR blanket modules a loss of coolant accident will result in melting of the lead rods after 1 minute and of the ss first wall after 3 minutes. Also partial melting and evaporization of the ss first wall as caused by plasma disruption was analysed. Part of the UKCTR-IIIA neutron reaction cross section data library is based on calculations using the nuclear-model code THRES-2. Results of a revision using the modified THRES-F code are reported. A combined preequilibrium and equilibrium model was applied for calculation of neutron emission spectra and of their angular distributions. Neutron transport calculations are reported to determine the polodial distribution of activation of various threshold detectors, which will be placed on the plasma chamber of JET as part of the diagnostic system. In vanadium the preinjection of helium by means of cyclotron irradiation is shown to lead to a lower cavity concentration and a slightly larger cavity size as a result of a following fast neutron irradiation in the core of the HFR reactor. In the V - 1% Cr - 0.1% Ti alloy preinjected helium has the opposite effect on cavity concentration and size. The ratio between helium production and displacement damage in ss 316 by irradiation in the HFR is shown to meet the fusion reactor condition. The development of high current superconducting niobium-tin cables is introduced as a new activity at ECN. Results are shown of a technique for welding multifilament wires. The conductor concept for a small prototype toroidal field coil is presented. Progress is reported of fabrication of a 8 Tesla niobium-titanium insert coil for the SULTAN conductor test facility

  2. The MERLIN programme: Pt. 5

    International Nuclear Information System (INIS)

    The MERLIN rig is intended to investigate the deformation behaviour of Zircaloy fuel rod cladding under conditions approximating those of a large break loss of coolant accident (LOCA). An assembly of electrically heated fuel rod simulators (6X6 cluster) is subjected to a temperature transient simulating that predicted to occur in a LOCA, including the initiation of bottom reflooding at a suitable stage. The Bundle B Thermal-Hydraulic test series was intended to commission the test facility and to obtain the operating conditions which would produce a suitable temperature transient for the investigation of clad ballooning at high coolant sub-channel blockages. In addition, the vibration produced by reflooding was to be measured during the course of the programme. The early stages of the programme (ramp test and low power reflooding tests) were successfully accomplished, although a major part of the test section instrumentation was found to be unreliable. A limited number of low power tests designed to investigate starting conditions was followed by an accelerated programme to derive a high temperature burst test transient, with the limited aim of allowing good rig commissioning data to be obtained. A successful burst test was carried out as the final experiment of the programme. (author)

  3. Carioca hospitality programme: Rio 2016

    OpenAIRE

    2016-01-01

    The "Hospitality programme" at the Rio 2016 Games venues was designed to attend the specific needs of partners and their clients in a transparent and flexible manner. In this guide, you will find information and standards that will help in your choice, and in the planning of this incredible experience.

  4. Summer Student Programme – Report

    CERN Document Server

    Bellora, Andrea

    2016-01-01

    This is the report on the studies about radiation damage on silicon strips detectors I've performed during my Summer Student Programme. A parameter to describe the damage amount has been defined, as well as his behaviour over time and absorbed dose.

  5. Portugal's Secondary School Modernisation Programme

    Science.gov (United States)

    Heitor, Teresa V.; Freire da Silva, Jose M. R.

    2009-01-01

    The aim of the Secondary School Modernisation Programme, being implemented in Portugal by "Parque Escolar, EPE", is based on the pursuit of quality and makes Portuguese education a potential international benchmark. This paper discusses the strategies adopted to reorganise school spaces. It describes the conceptual model and highlights the…

  6. Survey of environment related monitoring programmes of international organizations and their contribution to international monitoring programmes

    International Nuclear Information System (INIS)

    The report is a summary of environment-related monitoring programmes of international governmental organizations and their contribution to international monitoring programmes. it presents the situation as of November 1986: This survey has been prepared by a consultant for the Secretariat as a background document for the second meeting of the Environment Experts, Economic Summit in Munich, November 1986. It serves information purposes only. No claim for completeness is intended. This report may also prove to be helpful for administrators and the scientific community as regards gaining knowledge on present arrangements, approaches and environmental activities in the framework of international organizations. In this light, the present report could facilitate communication and progress in solving pressing environmental problems on the international level. (orig.)

  7. SUMMER STUDENT LECTURE PROGRAMME

    CERN Multimedia

    Academic Training; Tel. 73127

    2001-01-01

    Main Auditorium bldg. 500 Date Time Lecturer Title Wednesday 4 July 9:15 10:15 11:15 14:00 15:00 15:45 L. Maiani / CERN L. Maiani / CERN M. Franklin / CERN G. Stevenson M. Diemoz O. Ullaland Introduction to CERN & Particle Physics (1/2) Introduction to CERN & Particle Physics (2/2) Classic Experiments (1/3) CERN Radiation Protection CERN Information on Activities CERN Intro to workshops Thursday 5 July 9:15 10:15 11:15 14:00 15:00 16:30 M. Franklin / CERN M. Franklin / CERN M. Franklin / CERN F. Close F. Close   Classic Experiments (2/3) Classic Experiments (3/3) Discussion session Particle Physics (for non-physics students) (1/4) Particle Physics (for non-physics students) (2/4) Welcome Drink Friday 6 July 9:15 10:15 F. Close F. Close Particle Physics (for non-physics students) (3/4) Particle Physics (for non-physics students) (4/4) Monday 9 July 9:15 10:15 11:15 R. Kleiss / CERN L. Rolandi / CERN L. Rolandi / CERN Fundamental Concepts of Particle Physics (1/6) Big Experime...

  8. SUMMER STUDENT LECTURE PROGRAMME

    CERN Multimedia

    Academic Training; Tel. 73127

    2001-01-01

    Main Auditorium bldg. 500 Date Time Lecturer Title Wednesday 4 July 9:15 10:15 11:15 14:00 15:00 15:45 L. Maiani / CERN L. Maiani / CERN M. Franklin / CERN G. Stevenson M. Diemoz O. Ullaland Introduction to CERN & Particle Physics (1/2) Introduction to CERN & Particle Physics (2/2) Classic Experiments (1/3) CERN Radiation Protection CERN Information on Activities CERN Intro to workshops Thursday 5 July 9:15 10:15 11:15 14:00 15:00 16:30 M. Franklin / CERN M. Franklin / CERN M. Franklin / CERN F. Close F. Close   Classic Experiments (2/3) Classic Experiments (3/3) Discussion session Particle Physics (for non-physics students) (1/4) Particle Physics (for non-physics students) (2/4) Welcome Drink Friday 6 July 9:15 10:15 F. Close F. Close Particle Physics (for non-physics students) (3/4) Particle Physics (for non-physics students) (4/4) Further information can be obtained on the web at the following URL: http://cern.web.cern.ch/CERN/Divisions/PE/HRS/Recruitment/sum_prog99.html

  9. Language Training Programme

    CERN Multimedia

    HR Department

    2012-01-01

    General and Professional French Courses The next session will take place from 8 October to 14 December 2012. These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult this Web page. Oral Expression This course is aimed for students with a good knowledge of French who want to enhance their speaking skills. Speaking activities will include discussions, meeting simulations, role-plays etc. The next session will take place from 8 October to 14 December 2012. For registration and further information on the courses, please consult this Web page. Writing professional documents in French These courses are designed for non-French speakers with a very good standard of spoken French. The next session will take place from 8 October to 14 December 2012. For registration and further information on the courses, please consult this Web page. General and Professional English Courses The next sessions will take place: From 1...

  10. Action programme for youth.

    Science.gov (United States)

    Sulaiman, A B

    1993-01-01

    In Nigeria, where abortion is illegal, unmarried women under 20 years of age comprises the majority of abortion patients and complications from unsafe abortion represent a major health problem among this sector. The high incidence of abortion in Nigeria reflects increased premarital sex activity in urban areas; opposition to family planning, and cultural sanctions against single parenting or forced marriage. The Planned Parenthood Federation of Nigeria (PPFN) is working, cautiously, toward liberalization of the grounds for legal abortion; however, its major strategy is to avert the need for abortion through overcoming opposition to family planning services for young people and family life education in the schools. To reach young people, PPFN has begun providing services in medical clinics attached to vocational schools and institutes of higher education. The concept of using peers to distribute non-prescription contraceptives is being considered, and special youth clinics are planned for urban areas. About 5% of new acceptors at PPFN clinics are under 20 years of age, and attempts are being made to tailor services to the unique needs of this population.

  11. ADS National Programmes: Netherlands

    International Nuclear Information System (INIS)

    The ADS related activities within the Netherlands are concentrated at NRG. From 2000 to 2006, NRG supported SCK•CEN in their development of MYRRHA. The support was mainly devoted to Computational Fluid Dynamics (CFD) simulations for the windowless target option. This collaboration was prolonged within the framework of the EU FP6 EUROTRANS project. Eventually this lead to a solution strategy for the hydraulic (without heat transfer) evaluation of a windowless target with one free surface using an Eulerian-Eulerian modeling approach. As a second free surface was added to the target design later, this approach would need to be revisited. The developed approach was applied to an assess the feasibility of a three feeder windowless target design. This preliminary assessment confirmed that there were no serious show stoppers for a three feeder design. Another study undertaken using related to the windowless target was a preliminary assessment of the risk of lead-bismuth splashing in case of a sudden heat deposition by the beam, e.g. at beam startup or beam interuptions. Within the framework of the EU FP7 CDT project, a window target is currently being assessed thermalhydraulicly in collaboration with SCK•CEN. Within the EU FP5 ASCHLIM project, the state of the art with regard to turbulence modelling for CFD approaches was determined. It was concluded that accurate simulation of heat transport in HLM was not feasible, especially in natural or mixed convection regimes. Within the EU FP7 THINS project this issue is currently being treated. NRG assists the commercial CFD code vendor CD adapco in implementing and testing a promising, academically tested, algebraic heat flux model

  12. The International Comparison Programme: 2005 results and supporting the programme

    OpenAIRE

    Ben Whitestone

    2008-01-01

    Explores improvements made in the latest round of the ICP initiative and UK Government support for it in AfricaThe results of the International Comparison Programme (ICP) were released by the World Bank in December 2007. The ICP is a global initiative to collect comparative price data and estimate relative price levels between countries. These figures allow international comparisons of real economic wealth to be made, and hence provide an essential tool for governments designing aid, trade an...

  13. Impact evaluation of child nutrition programmes

    NARCIS (Netherlands)

    Hoorweg, J.C.

    1988-01-01

    Review of current practices and recent developments in impact evaluation of nutrition programmes for preschool children in developing countries. A survey of the major types of nutrition programmes for young children - nutrition education, food supplementation, and nutrition rehabilitation - is follo

  14. Planning and implementation of nuclear research programmes

    International Nuclear Information System (INIS)

    The planning and implementation of nuclear research programmes in developed and developing countries is discussed. The main aspects of these programmes in USA, France, Japan, India and Brazil are reported. (M.W.O.)

  15. Radiochemistry programme biennial progress report (1986 and 1987)

    International Nuclear Information System (INIS)

    This biennial report covers the calendar years 1986 and 1987. This period has seen significant growth in the research activities of the Radiochemistry Programme and this is reflected in this report. The report is organised subject-wise into sections dealing with Fuel Chemistry and Thermodynamics, Sodium Chemistry, Analytical Chemistry and Instrumentation. The major part of the activities of the Radiochemistry Programme relates to fuel chemistry including thermophysical and thermodynamic properties of fuel materials, chemistry of fuel reprocessing and facilities as well as techniques for post-irradiation studies. Sodium chemistry is a smaller but important R and D activity, which has reached full maturity during the period of this report. Analytical chemistry and instrumentation are essential supporting activities. The rapid progress made over the last two years are reflected in the number of items covered in this report. In order to keep the total length of this report under control, the editors had to restrict the individual activities to one or two pages. Though the details of various studies are not presented here, it is hoped that the report gives an overview of the progress made by the Radiochemistry Programme in the last two years. The list of publications given at the end also reflects the growth in research programmes. (author)

  16. The JOSHUA (J80) system programmer`s manual

    Energy Technology Data Exchange (ETDEWEB)

    Smetana, A.O.; McCort, J.T.; Westmoreland, B.W.

    1993-08-01

    The JOSHUA system routines (JS routines) can be used to manage a JOSHUA data base and execute JOSHUA modules on VAX/VMS and IBM/MVS computer systems. This manual provides instructions for using the JS routines and information about the internal data structures and logic used by the routines. It is intended for use primarily by JOSHUA systems programmers, however, advanced applications programmers may also find it useful. The JS routines are, as far as possible, written in ANSI FORTRAN 77 so that they are easily maintainable and easily portable to different computer systems. Nevertheless, the JOSHUA system provides features that are not available in ANSI FORTRAN 77, notably dynamic module execution and a data base of named, variable length, unformatted records, so some parts of the routines are coded in nonstandard FORTRAN or assembler (as a last resort). In most cases, the nonstandard sections of code are different for each computer system. To make it easy for programmers using the JS routines to avoid naming conflicts, the JS routines and common block all have six character names that begin with the characters {open_quotes}JS.{close_quotes} Before using this manual, one should be familiar with the JOSHUA system as described in {open_quotes}The JOSHUA Users` Manual,{close_quotes} ANSI FORTRAN 77, and at least one of the computer systems for which the JS routines have been implemented.

  17. Rural Energy Development Programme-Nepal

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    On 16 Auguest 1996 the Rural Energy Develoment Programme (REDP) was initiated with the aim of improving livelihoods of rural people and pressrving the environment through the promotion of rural energy systems. The Programme is run by the United Nations Deelopment Programme and His Majesty's Government of Nepal.

  18. School Security Assessment Programme in Australia

    Science.gov (United States)

    Marrapodi, John

    2007-01-01

    This article describes a successful security risk management programme in Australia. The state-wide programme follows a structured risk management approach focusing on the safety and security of people, information, provision, and assets in the school environment. To assist school principals, a Security Risk Assessment Programme was developed on a…

  19. JavaScript programmer's reference

    CERN Document Server

    Valentine, Thomas

    2013-01-01

    JavaScript Programmer's Reference is an invaluable resource that won't stray far from your desktop (or your tablet!). It contains detailed information on every JavaScript object and command, and combines that reference with practical examples showcasing how you can use those commands in the real world. Whether you're just checking the syntax of a method or you're starting out on the road to JavaScript mastery, the JavaScript Programmer's Reference will be an essential aid.  With a detailed and informative tutorial section giving you the ins and outs of programming with JavaScript and the DOM f

  20. Programmable Grit-Blasting System

    Science.gov (United States)

    Burley, Richard K.

    1988-01-01

    In programmable grit-blasting system undergoing design, controller moves blasting head to precise positions to shape or remove welding defects from parts. Controller holds head in position for preset dwell time and moves head to new position along predetermined path. Position of articulated head established by pair of servomotors according to programmed signals from controller. Head similar to video borescope. Used to remove welding defects in blind holes. Suited for repetitive production operations in grit-blast box.

  1. LEP Celebration : the official programme

    CERN Document Server

    CERN. Geneva

    2000-01-01

    At 14:00: Groupe de Jazz "Wolfgang & The Werewolves" . The official programme begins at 15:00 with an introduction from the Director General, and Professor Martinus Veltman will give the keynote speech. Heads of national delegations represented at ministerial level will then make their speeches, following which a commemorative plaque will be unveiled. A specially commissioned ballet by Maurice Béjart will bring the ceremony to a close.

  2. Fast reactor programme in India

    Indian Academy of Sciences (India)

    P Chellapandi; P R Vasudeva Rao; Prabhat Kumar

    2015-09-01

    Role of fast breeder reactor (FBR) in the Indian context has been discussed with appropriate justification. The FBR programme since 1985 till 2030 is highlighted focussing on the current status and future direction of fast breeder test reactor (FBTR), prototype fast breeder reactor (PFBR) and FBR-1 and 2. Design and technological challenges of PFBR and design and safety targets with means to achieve the same are the major highlights of this paper.

  3. Guam Fish Aggregating Device programme

    OpenAIRE

    Torres, A.

    2000-01-01

    Installation and maintenance of FADs by the Government of Guam began in 1979, initially with funding from the Salstonstall-Kennedy Act through the Pacific Tuna Development Foundation. Current funding for the Guam FAD project is provided through the Dingell-Johnson/Wallop-Breaux Sport Fish Restoration programme, a Federal Aid Project funded by taxes collected on the purchase of fishing equipment and motorboat fuels nationwide. There are now sixteen operational FAD sites in Guam's waters. At a ...

  4. The MERLIN programme: Pt. 9

    International Nuclear Information System (INIS)

    The MERLIN rig is intended to investigate the deformation behaviour of Zircaloy fuel rod cladding under conditions approximating those of a large break LOCA. A preliminary series of experiments (the MERLIN Bundle B programme) has been carried out, with the aim of characterising the rig. This series of experiments concluded with a burst test, during which the cladding of a number of fuel rod simulators distended and burst. This Report describes the post test examination of the Bundle. (author)

  5. Current programmes on physical metallurgy and related areas in BARC

    International Nuclear Information System (INIS)

    Current research and development programmes on physical metallurgy and related areas from the following Divisions of Bhabha Atomic Research Centre are included in this report : Atomic Fuels Division, High Pressure Physics Division, Metallurgy Division, Radio Metallurgy Division, Solid State Physics Division. Important publications corresponding to each activity have also been listed. (author)

  6. Inr training programme in nuclear research

    International Nuclear Information System (INIS)

    The field of scientific research goes through rapid changes to which organizations must dinamically and efficiently adapt, which leads to the need to develop a continuous learning process that should be the basis for a long-term operational performance. Thus, human resource management systems and continuous learning should be perfectly correlated/alligned with the organizational strategy and knowledge. The research institutes through the nature of their activity are constantly undergoing a transformation process by exploring new research areas which presumes ensuring competent human resources who have to continuously learn and improve. The «learning organization » concept represents a metaphor rooted in the search of a strategy for promoting the personal development of the individual within an organization through a continuous transformation. Learning is associated with the idea of continuous transformation based on the individual and organizational development. Within « learning organizations » the human development strategy occupies a central role in management strategies. It was learned that organizations which perform excellently depend on the employees committment, especially in the budget constraints environment. For this, the human resources have to be used at maximum capacity but this is possible only with an increased committment of the employee towards the organization. The purpose of this paper is to present the basic training programme for the new employees which is part of the training strategy which carry out activities in the nuclear field of SCN Pitesti. With the majority of the research personnel aged between 45 and 60 years old there is the risk of loosing the knowledge gained in this domain. The expertise gained by experienced experts in the institute nationally and internationally can be exploited through the knowledge transfer to the new employees by organizing training programmes. The knowledge transfer between generations is one of the

  7. Final report of the Water Security Knowledge Exchange Programme, April 2011 – March 2014

    OpenAIRE

    Tindall, Isabella; Jenkins , Alan

    2014-01-01

    This document is the Final Report for the Natural Environment Research Council (NERC) Water Security Knowledge Exchange Programme (WSKEP) which ran from April 2011 – March 2014. It highlights the outcomes, benefits and impacts of the Programme’s activities, notes key achievements and outputs, describes case examples, presents learning and legacy issues including Programme recommendations and provides a financial statement.

  8. A Process Evaluation of Student Participation in a Whole School Food Programme

    Science.gov (United States)

    Orme, Judy; Jones, Matthew; Salmon, Debra; Weitkamp, Emma; Kimberlee, Richard

    2013-01-01

    Purpose: Health promotion programmes are widely held to be more effective when the subjects of them actively participate in the process of change. The purpose of this paper is to report on an evaluation of the Food for Life Partnership programme, a multi-level initiative in England promoting healthier nutrition and food sustainability awareness…

  9. Need for a realistic mental health programme in India

    Directory of Open Access Journals (Sweden)

    Barua Ankur

    2009-01-01

    Full Text Available India, with a population of a billion, has very limited numbers of mental health facilities and professionals in providing mental health care to all the people. The disability associated with mental or brain disorders stops people from working and engaging in other creative activities. Gradual implementation of district mental health programme in a phased manner with support of adequate managerial and financial inputs is the need of the day. Trained mental health care personnel, treatment, care, and rehabilitation facilities should be made available and accessible to the masses. The voluntary organizations should be encouraged to participate in mental health care programme.

  10. Competences and life management programmes

    International Nuclear Information System (INIS)

    Full text: The nuclear industry is, at present, at a crucial juncture, where it has to decide about the future of the first generation of nuclear plants, which are approaching the end of their licensed service life. At the same time, long term experience and new advances have established that it is possible to extend the life of nuclear plants beyond their initially licensed life by another 20-30 years. Extending the operating life of existing nuclear plants will help to reduce the short term need for new generating capacity - without new capital costs. However, these extensions must take place in the context of careful safety analysis and monitoring of equipment ageing concerns. A nuclear power plant must be managed in a safe and efficient manner throughout all the life cycle stages from design through decommissioning. The consequences of management decisions about nuclear power plants can have profound economic impacts for the nuclear power plant owner, and possibly for the national economy. In addition, the consequence of a major failure or accident can have catastrophic national socio-economic effects that may be felt internationally. The safe and effective management of a nuclear power plant therefore requires dramatically different perspectives in time from the majority of other industries. The impact of some decisions extends beyond the normal strategic perspective of both owners and governments. The integration of activities for ageing management, safety management and business management of a nuclear power plant are an essential element of 'life cycle management'. The loss of information at any stage of a nuclear power plants life deprives people, at later stages, of knowledge that could be important to safe, economic completion of work or which could aid the analysis of problems and options. It is costly to go through the learning process again, with a risk of potential events or incidents, programme delays, physical injury and increased regulatory

  11. QUALITY OF AN ACADEMIC STUDY PROGRAMME - EVALUATION MODEL

    Directory of Open Access Journals (Sweden)

    Mirna Macur

    2016-01-01

    Full Text Available Quality of an academic study programme is evaluated by many: employees (internal evaluation and by external evaluators: experts, agencies and organisations. Internal and external evaluation of an academic programme follow written structure that resembles on one of the quality models. We believe the quality models (mostly derived from EFQM excellence model don’t fit very well into non-profit activities, policies and programmes, because they are much more complex than environment, from which quality models derive from (for example assembly line. Quality of an academic study programme is very complex and understood differently by various stakeholders, so we present dimensional evaluation in the article. Dimensional evaluation, as opposed to component and holistic evaluation, is a form of analytical evaluation in which the quality of value of the evaluand is determined by looking at its performance on multiple dimensions of merit or evaluation criteria. First stakeholders of a study programme and their views, expectations and interests are presented, followed by evaluation criteria. They are both joined into the evaluation model revealing which evaluation criteria can and should be evaluated by which stakeholder. Main research questions are posed and research method for each dimension listed.

  12. Evaluation of the Finnish nuclear waste management programme

    International Nuclear Information System (INIS)

    In response to a request from Finland in November 1992, the International Atomic Energy Agency (IAEA) set up a Team of four experts (representatives from Belgium, Canada, Germany and Switzerland) to review the Finnish nuclear waste management programme within the auspices of IAEA's Waste Management programme (WATRP). During the early summer of 1993, the Team reviewed a large amount of documentation supplied by the Finnish industry, government and research organizations. The radioactive waste management programme areas within the Team's terms of reference included: (1) work being done in siting and building a conditional facility for spent nuclear fuel and siting and constructing a co-located repository, (2) the plans and activities for conditioning and disposing of the low and intermediate level waste from Finland's NPPs and (3) the plans for decommissioning Finland's reactors when that becomes necessary. The evaluation work and the recommendations of the Team are detailed in the report

  13. Malaysia's entry into a neutron-scattering programme

    International Nuclear Information System (INIS)

    The neutron-scattering programme in Malaysia had been planned and re-planned since 1982, soom after Malaysia's first research reactor was commissioned. Currently, and most definitely, the neutron-scattering programme will start off with small-angle neutron-scattering (SANS). This seems to be in contrast with other nations' neutron-scattering programmes where the usual activity would first be neutron diffraction. This paper gives the reasons behind the selection of small-angle neutron-scattering (SANS) as a starting point. The design of Malaysia's SANS instrument and its expected applications will be explained. Other matters, especially those related to expected future developments or arrangements will also be discussed. (author)

  14. International programme on the health effects of the Chernobyl accident

    International Nuclear Information System (INIS)

    Two years ago the World Health Assembly approved the establishment of the International Programme on the Health Effects of the Chernobyl Accident (IPHECA). The Programme, set up under the auspices of WHO, provides support to the health authorities in Belarus, the Russian Federation and the Ukraine in dealing with the aftermath of the accident, and is intended to serve as a unifying framework for all international health-related activities arising from the accident carried out in the three countries. This document outlines the Programme's objectives, structure, accomplishments and future plans. As a background, it also provides a brief overview of the accident and of its current and potential impact on health in the three countries. 5 figs, 1 tab

  15. Foresight and strategy in national research councils and research programmes

    DEFF Research Database (Denmark)

    Andersen, Per Dannemand; Borup, Mads

    2009-01-01

    This paper addresses the issue of foresight and strategy processes of national research councils and research programmes. It is based on a study of strategy processes in national research councils and programmes and the challenges faced by their strategy activities. We analysed the strategy...... processes of two organisations: the Danish Technical Research Council and the Danish Energy Research Programme. We analysed the mechanisms of the strategy processes and studied the actors involved. The actors’ understanding of strategy was also included in the analysis. Based on these analyses we argue...... that the impact of foresight exercises can be improved if we have a better understanding of the traditions and new challenges faced by the research councils. We also argue that a more formal use of foresight elements might improve the legitimacy and impact of the strategic considerations of research councils...

  16. Gas cooled fast reactor background, facilities, industries and programmes

    International Nuclear Information System (INIS)

    This report was prepared at the request of the OECD-NEA Coordinating Group on Gas Cooled Fast Reactor Development and it represents a contribution (Vol.II) to the jointly sponsored Vol.I (GCFR Status Report). After a chapter on background with a brief description of the early studies and the activities in the various countries involved in the collaborative programme (Austria, Belgium, France, Germany, Japan, Sweden, Switzerland, United Kingdom and United States), the report describes the facilities available in those countries and at the Gas Breeder Reactor Association and the industrial capabilities relevant to the GCFR. Finally the programmes are described briefly with programme charts, conclusions and recommendations are given. (orig.)

  17. A preventive dental care programme at the workplace.

    Science.gov (United States)

    Westerman, B

    1993-06-01

    Employees from an industrial group in Brisbane were examined at the workplace and found to have generally low levels of dental disease. At the same time, the Australian Bureau of Statistics suggests that less than 45 per cent of Australians attend a dentist annually. This low attendance for regular dental care reduces the effectiveness of any preventive dental service. A pilot scheme of preventive dental care was provided for employees at the workplace in Brisbane. The aim of the programme was to provide regular health counselling and reinforcement of oral health activities, general dental information, regular prophylaxis, scaling and cleaning, and referrals for restorative care. The preventive programme was appropriate given the disease levels. The services were effective in improving the periodontal status and restorative care which resulted from referrals. As well, the preventive dental care programme proved to be readily acceptable to both employees and management.

  18. Swiss Biomass Programme - Overview report on the 2007 research programme; Programm Biomasse: Ueberblicksbericht zum Forschungsprogramm 2007

    Energy Technology Data Exchange (ETDEWEB)

    Binggeli, D.; Guggisberg, B.

    2008-07-01

    This illustrated report for the Swiss Federal Office of Energy (SFOE) presents an overview of the results obtained in 2007 within the framework of the Swiss Biomass research programme. The potential for biomass use in Switzerland is reviewed and the emphases of the national programme are discussed. The results obtained are noted for the following areas: process optimisation, including - amongst others - particle emissions and control aspects as well as combined wood-pellets and solar heating systems. Projects involving non-wood biomass are reported on, including biomass digesters and various biogas systems. Further reports deal with the analysis and optimisation of material flows, organic pollutants and methane losses. New conversion technologies are reported on. Further reports deal with basic strategies and concepts in the area of biomass usage. National and international co-operation is also discussed. A selection of innovative pilot and demonstration projects is also presented and research and development projects are listed.

  19. Enlargement of the External Mobility Programme

    CERN Multimedia

    HR Department

    2008-01-01

    The External Mobility Programme was launched at the end of September 2007. Initially, the programme was aimed at staff members on limited-duration contracts, having received formal notification of the termination of their employment contract at CERN, to help them towards their next employment. The programme provides a privileged, fast-track entry into the recruitment process of partner companies. Despite the short time since its inception, the programme has already delivered some encouraging and concrete results in terms of interviews granted to participating staff. The Programme has raised considerable interest from both CERN personnel as well as from several major European companies. CERN Management has decided to broaden the scope of the External Mobility Programme. The Programme is now open to: All staff members whose limited duration contract will end in less than one year, as well as all those with indefinite contracts. All fellows who have been employed by CERN fo...

  20. Enlargement of the External Mobility Programme

    CERN Multimedia

    HR Department

    2008-01-01

    The External Mobility Programme was launched at the end of September 2007. Initially, the programme was aimed at staff members on limited-duration contracts having received formal notification of the termination of their employment contract at CERN, to help them towards their next employment. The programme provides a privileged, fast-track entry into the recruitment process of partner companies. Despite the short time since its inception, the programme has already delivered some encouraging and concrete results in terms of interviews granted to participating staff. The Programme has attracted considerable interest from both CERN personnel as well as from several major European companies. The CERN Management has decided to broaden the scope of the External Mobility Programme. The Programme is now open to: All staff members whose limited duration contract will end in less than one year, as well as all those with indefinite contracts. All fellows who have been employed by CE...