Sample records for activity centers

  1. Student-Centered Reading Activities. (United States)

    Moffett, James; Wagner, Betty Jane


    Offers student-centered reading activities designed to bring students to reading maturity and involvement in literature. Discusses partner reading, dramatizing and performing texts, transforming texts, journal writing, discussion, and writing. (PRA)

  2. Adult Learning Center Curriculum Activities. (United States)

    City Univ. of New York, Bronx. Herbert H. Lehman Coll. Inst. for Literacy Studies.

    These curriculum materials were collected from teachers in the Lehman College Adult Learning Center (New York). They include various activities and resources, such as a series of questions about the aims of teaching adults, a list of sources for adult basic education (ABE) materials, poems, and autobiographical materials. Teaching suggestions and…

  3. Electrolysis activities at FCH Test Center

    DEFF Research Database (Denmark)

    Ravn Nielsen, Eva; Nygaard, Frederik Berg

    FCH Test Center for fuel cell and hydrogen technologies was established in 2010 at Risø DTU in Denmark. Today, the test center is part of DTU Energy Conversion. The center gives industry access to advanced testing and demonstration of components and systems. A number of national projects and EU...... projects regarding water electrolysis involve FCH Test Center as a partner. This presentation gives an overview of the activities....

  4. Activities of the NEDO information center

    Energy Technology Data Exchange (ETDEWEB)



    Under the situation where items of information related to energy and industrial technologies (including environmental technologies) are diversified and internationalized, the NEDO Information Center opens its book and data rooms, performs database service and information exchange activities with other countries, and issues information journals. These activities are intended to respond accurately and quickly to users` information needs. This paper reports the result of operations during fiscal 1994. Retained and provided for public reading at the Center are 2,200 reports on results of research and development works having been carried out by NEDO, 3,800 books and data published inside and outside Japan mainly on new energies, and 190 kinds of periodical publications. The first nationwide geothermal result charts are also reproduced and sold. Technological literature and information prepared by IEA which have been obtained based on the energy technological data exchange treaty and the implementation treaty on establishment of IEA coal research have been recorded as the NEDO-EDBS and offered on line. This paper also introduces the optical databases. The agreement on the IEA Information Centers for the Analysis and Dissemination of Demonstrated Energy Technologies (CADDET) is also available. Descriptions are given also on activities of the Greenhouse Gas Technology Information Exchange (GREENTIE).

  5. Catawba Science Center solar activities. Final report

    Energy Technology Data Exchange (ETDEWEB)



    Two demonstration solar water heaters were built. One was to be used at the Science Center and the other with traveling programs. This was completed and both units are being used for these programs which continue. We were able to build a library of 99 solar energy books and booklets that are available to the public for reference. We also conducted programs for 683 students of all ages. The culminating activity was the planned Energy Awareness Festival. This was held on September 26, 1981 and attracted 450 area citizens. We offered free exhibit space and hosted 17 exhibitors.


    Directory of Open Access Journals (Sweden)



    Full Text Available International financial centers are places of concentration banking and specialized financial institutions activities, engaged in international financial transactions. They have become elements of international market mechanisms that serve as controls global financial flows. The movement of the past carried out in the field of monetary and settlement services for the sale of goods and services, international investments, transactions with various financial instruments, foreign currency transactions. They have become points of support of financial globalization process, ensuring the normal circulation of international financial flows, and the link between local and international financial markets. This article examines the essence, the types and importance of specific territorial formations in the context of globalization.

  7. 75 FR 22438 - Proposed Information Collection (Health Resource Center Medical Center Payment Form) Activity... (United States)


    ... AFFAIRS Proposed Information Collection (Health Resource Center Medical Center Payment Form) Activity... information technology. Title: Health Resource Center Medical Center Payment Form, VA Form 10-0505. OMB... proposed collection of certain information by the agency. Under the Paperwork Reduction Act (PRA) of...

  8. Supporting Human Activities - Exploring Activity-Centered Computing

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Bardram, Jakob


    In this paper we explore an activity-centered computing paradigm that is aimed at supporting work processes that are radically different from the ones known from office work. Our main inspiration is healthcare work that is characterized by an extreme degree of mobility, many interruptions, ad...... objects. We also present an exploratory prototype design and first implementation and present some initial results from evaluations in a healthcare environment....

  9. Activity report of Computing Research Center

    Energy Technology Data Exchange (ETDEWEB)


    On April 1997, National Laboratory for High Energy Physics (KEK), Institute of Nuclear Study, University of Tokyo (INS), and Meson Science Laboratory, Faculty of Science, University of Tokyo began to work newly as High Energy Accelerator Research Organization after reconstructing and converting their systems, under aiming at further development of a wide field of accelerator science using a high energy accelerator. In this Research Organization, Applied Research Laboratory is composed of four Centers to execute assistance of research actions common to one of the Research Organization and their relating research and development (R and D) by integrating the present four centers and their relating sections in Tanashi. What is expected for the assistance of research actions is not only its general assistance but also its preparation and R and D of a system required for promotion and future plan of the research. Computer technology is essential to development of the research and can communize for various researches in the Research Organization. On response to such expectation, new Computing Research Center is required for promoting its duty by coworking and cooperating with every researchers at a range from R and D on data analysis of various experiments to computation physics acting under driving powerful computer capacity such as supercomputer and so forth. Here were described on report of works and present state of Data Processing Center of KEK at the first chapter and of the computer room of INS at the second chapter and on future problems for the Computing Research Center. (G.K.)

  10. Activity report of Mechanical Engineering Center

    Energy Technology Data Exchange (ETDEWEB)


    On April 1997, National Laboratory for High Energy Physics (KEK), Institute of Nuclear Study, University of Tokyo (INS), and Meson Science Laboratory; Faculty of Science, University of Tokyo began to work newly as High Energy Accelerator Research Organization after reconstructing and converting their systems, under aiming at further development of a wide field of accelerator science using a high energy accelerator. Hitherto, the large scale research plans of accelerator at the KEK have been not only received their relation communities on learning importance, meanings and social factors from their stages, but also promoted carefully under opinions and evaluation of outer objective ones and received outer serious evaluations for established research results either. Mechanical Engineering Center belonging to Applied Research Laboratory in the new Organization, started under jointing some sections relating to KEK and INS. As separately operating at the old organization engineering center in Tsukuba area and at engineering room in Tanashi Laboratory for some years, the Center was intended to integrate after 2000 to use this evaluation results for future development. This report was prepared separately on actions at the old engineering center of KEK as its first section and the engineering room of INS as its second section. (G.K.)

  11. 75 FR 39622 - Proposed Information Collection (Health Resource Center Medical Center Payment Form) Activity... (United States)


    ... AFFAIRS Proposed Information Collection (Health Resource Center Medical Center Payment Form) Activity... collection of information abstracted below to the Office of Management and Budget (OMB) for review and comment. The PRA submission describes the nature of the information collection and its expected cost...

  12. Marshall Space Flight Center ECLSS technology activities (United States)

    Wieland, Paul


    Viewgraphs on Environmental Control and Life Support System (ECLSS) technology activities are presented. Topics covered include: analytical development; ECLSS modeling approach; example of water reclamation modeling needs; and hardware development and testing.

  13. Software package as an information center product. [Activities of Argonne Code Center

    Energy Technology Data Exchange (ETDEWEB)

    Butler, M. K.


    The Argonne Code Center serves as a software exchange and information center for the U.S. Energy Research and Development Administration and the Nuclear Regulatory Commission. The goal of the Center's program is to provide a means for sharing of software among agency offices and contractors, and for transferring computing applications and technology, developed within the agencies, to the information-processing community. A major activity of the Code Center is the acquisition, review, testing, and maintenance of a collection of software--computer systems, applications programs, subroutines, modules, and data compilations--prepared by agency offices and contractors to meet programmatic needs. A brief review of the history of computer program libraries and software sharing is presented to place the Code Center activity in perspective. The state-of-the-art discussion starts off with an appropriate definition of the term software package, together with descriptions of recommended package contents and the Carter's package evaluation activity. An effort is made to identify the various users of the product, to enumerate their individual needs, to document the Center's efforts to meet these needs and the ongoing interaction with the user community. Desirable staff qualifications are considered, and packaging problems, reviewed. The paper closes with a brief look at recent developments and a forecast of things to come. 2 tables. (RWR)


    Directory of Open Access Journals (Sweden)

    Meike Kumaat


    Full Text Available Development of land use in public facilities such as shopping center and school gives an impact on transportation problem in Manado City, North Sulawesi.  To determine factors which have causal relationship with congestion  as a result of school and shopping center activity then it need to be assessed and studied.  Descriptive study with observational survey was used in this study. The study ran Structural Equation Modelling (SEM by using AMOS program. Estimated method was used to calculate sample size then found 300 repondents, comprised : visitors and mall managers, school visitors, parents, school managers, Public Works department, and urban planning department .The study yielded a statistically significant correlation between  school and shopping center activity with congestion s. The result  indicated that school activity was positively related to congestion with p value  at p=0,000 (p ≤ 0,05. Shopping center activity was positively related to congestion with p value  at p=0,000 (p ≤ 0,05. The closer proximity from school to shooping center will causes severe traffic congestion. The relationship between school facility with proximity was found in p value at  p=0,000 (p ≤ 0,05 . The relationship between shopping center facility with proximity was found in p value at  p= 0,020 (p ≤ 0,05. While, the relationship between proximity with congestion was p= 0,008 (p ≤ 0,05. Monastery school and Mega Mall activity were affecting congestion because a closer proximity of two facilities. This indicates that the occurence of traffic congestion in Monastery School  may be dependent on existence of  Piere Tendean road link


    Directory of Open Access Journals (Sweden)

    Svetlana Petrovna Shtumpf


    Full Text Available The reality of life today is set the challenge and create the preconditions for youth associations in the diverse groups and movements. Such unity is a unifying factor in shaping the collective consciousness of the group, the basic concepts of the spiritual and moral values of shared responsibility on the individual, group and societal levels. In this work the motives of familiarizing young people to the activities of such organizations, the specifics of the youth socialization issues of leadership in them. Peculiarities of organizational core movement – the youth center, its structural composition, mechanism of operation, providing the main areas of work - organizational, methodical and information. Is proposed the collection practices, subjects, activities implemented in the work of youth organizations. We discuss the possible risks related to the status of the leader and worker center, with a possible negative impact of group on the individual participant. Attention is drawn to the importance of personal competences of worker of youth centers.


    Directory of Open Access Journals (Sweden)

    Sharadkumar Pralhad Sawant


    Full Text Available The importance of Anatomy in undergraduate medical education cannot be adequately emphasised. For doctors, the human body is the focus of investigation and intervention on a daily basis; for this reason, the study of anatomy in some form, will continue to be essential to safe medical practice. It is necessary for core knowledge of anatomy to be assimilated by all doctors in order to practice medicine safely. It may be true that most doctors do not need to dissect a cadaver or study a prosection in order to practice, but if they do, it can improve their understanding and this surely has to be of benefit both for the safety of the patient and satisfaction of the doctor as a professional. Teacher-centered typically refers to learning situations in which the teacher asserts control over the material that students study. In contrast,to teacher centered learning, student-centered typically refers to forms of instruction that, for example, give students opportunities to lead learning activities, participate more actively in discussions, design their own learning projects, explore topics that interest them, and generally contribute to the design of their own course of study. Additionally, student-centered instruction is often associated with classrooms that feature desks arranged in circles or small groups (rather than rows of desks that face the teacher, with “self-guided” or “self-paced” learning, or with learning experiences that occur outside of traditional classroom settings. Anatomy teaching has undergone major changes due to time constraints and the rapid advances in computer technology. Also there has been a shift a teaching methodologies from a passive didactic teacher- centered approach to an active student - centered approach. Conclusion: We should develop and implement an instructional design that focuses on incorporating active-learning and student-centered pedagogy into what is previously a traditional lecture-based course. These

  17. SFC - The Solar activity and geomagnetic indices Forecast Center (United States)

    Valette, Jean-Jacques; Nicolas, Fuller; Philippe, Yaya

    CLS which operates SFC still maintains close collaboration with scientific laboratories or the Space Agencies in order to improve the prediction service performances and to extend the range of its applications. SFC also participates to ISES activities as an Associate Regional Warning Center.

  18. Climate Change Adaptation Science Activities at NASA Johnson Space Center (United States)

    Stefanov, William L.; Lulla, Kamlesh


    The Johnson Space Center (JSC), located in the southeast metropolitan region of Houston, TX is the prime NASA center for human spaceflight operations and astronaut training, but it also houses the unique collection of returned extraterrestrial samples, including lunar samples from the Apollo missions. The Center's location adjacent to Clear Lake and the Clear Creek watershed, an estuary of Galveston Bay, puts it at direct annual risk from hurricanes, but also from a number of other climate-related hazards including drought, floods, sea level rise, heat waves, and high wind events all assigned Threat Levels of 2 or 3 in the most recent NASA Center Disaster/Risk Matrix produced by the Climate Adaptation Science Investigator Working Group. Based on prior CASI workshops at other NASA centers, it is recognized that JSC is highly vulnerable to climate-change related hazards and has a need for adaptation strategies. We will present an overview of prior CASI-related work at JSC, including publication of a climate change and adaptation informational data brochure, and a Resilience and Adaptation to Climate Risks Workshop that was held at JSC in early March 2012. Major outcomes of that workshop that form a basis for work going forward are 1) a realization that JSC is embedded in a regional environmental and social context, and that potential climate change effects and adaptation strategies will not, and should not, be constrained by the Center fence line; 2) a desire to coordinate data collection and adaptation planning activities with interested stakeholders to form a regional climate change adaptation center that could facilitate interaction with CASI; 3) recognition that there is a wide array of basic data (remotely sensed, in situ, GIS/mapping, and historical) available through JSC and other stakeholders, but this data is not yet centrally accessible for planning purposes.

  19. An off-centered active galactic nucleus in NGC 3115

    CERN Document Server

    Menezes, R B; Ricci, T V


    NGC 3115 is an S0 galaxy that has always been considered to have a pure absorption-line spectrum. Some recent studies have detected a compact radio-emitting nucleus in this object, coinciding with the photometric center and with a candidate for the X-ray nucleus. This is evidence of the existence of a low-luminosity active galactic nucleus (AGN) in the galaxy, although no emission line has ever been observed. We report the detection of an emission-line spectrum of a type 1 AGN in NGC 3115, with an H$\\alpha$ luminosity of $L_{H\\alpha} = (4.2 \\pm 0.4) \\times 10^{37}$ erg s$^{-1}$. Our analysis revealed that this AGN is located at a projected distance of $\\sim 0.29" \\pm 0.05"$ (corresponding to $\\sim 14.3 \\pm 2.5$ pc) from the stellar bulge center, which is coincident with the kinematic center of this object's stellar velocity map. The black hole corresponding to the observed off-centered AGN may form a binary system with a black hole located at the stellar bulge center. However, it is also possible that the dis...

  20. Land processes distributed active archive center product lifecycle plan (United States)

    Daucsavage, John C.; Bennett, Stacie D.


    The U.S. Geological Survey (USGS) Earth Resources Observation and Science (EROS) Center and the National Aeronautics and Space Administration (NASA) Earth Science Data System Program worked together to establish, develop, and operate the Land Processes (LP) Distributed Active Archive Center (DAAC) to provide stewardship for NASA’s land processes science data. These data are critical science assets that serve the land processes science community with potential value beyond any immediate research use, and therefore need to be accounted for and properly managed throughout their lifecycle. A fundamental LP DAAC objective is to enable permanent preservation of these data and information products. The LP DAAC accomplishes this by bridging data producers and permanent archival resources while providing intermediate archive services for data and information products.

  1. 75 FR 49946 - National Drug Intelligence Center: Agency Information Collection Activities: Proposed Extension... (United States)


    ... National Drug Intelligence Center: Agency Information Collection Activities: Proposed Extension With Change... Response System. The United States Department of Justice (DOJ), National Drug Intelligence Center (NDIC... Intelligence Center, Fifth Floor, 319 Washington Street, Johnstown, PA 15901. Written comments and...

  2. [Research activities in Kobe-Indonesia Collaborative Research Centers]. (United States)

    Utsumi, Takako; Hayashi, Yoshitake; Hotta, Hak


    Kobe-Indonesia Collaborative Research Center was established in Institute of Tropical Disease (ITD), Airlangga University, Surabaya, Indonesia in 2007 under the program of ''Founding Research Centers for Emerging and Reemerging Infectious Diseases'' supported by the Ministry of Education, Culture, Sports, Science and Technology, Japan, and then it has been under the Japan Initiative for Global Research Network on Infectious Diseases (J-GRID) since 2010. Japanese researchers have been stationed at ITD, conducting joint researches on influenza, viral hepatitis, dengue and infectious diarrhea. Also, another Japanese researcher has been stationed at Faculty of Medicine, University of Indonesia, Jakarta, carrying out joint researches on'' Identification of anti-hepatitis C virus (HCV) substances and development of HCV and dengue vaccines'' in collaboration with University of Indonesia and Airlangga University through the Science and Technology Research Partnership for Sustainable Development (SATREPS) supported by the Japan Science and Technology Agency (JST) and Japan International Cooperation Agency (JICA) since 2009. In this article, we briefly introduce the background history of Kobe University Research Center in Indonesia, and discuss the research themes and outcomes of J-GRID and SATREPS activities.

  3. Carbon Nanotube Activities at NASA-Johnson Space Center (United States)

    Arepalli, Sivaram


    Research activities on carbon nanotubes at NASA-Johnson Space Center include production, purification, characterization and their applications for human space flight. In-situ diagnostics during nanotube production by laser oven process include collection of spatial and temporal data of passive emission and laser induced fluorescence from C2, C3 and Nickel atoms in the plume. Details of the results from the "parametric study" of the pulsed laser ablation process indicate the effect of production parameters including temperature, buffer gas, flow rate, pressure, and laser fluence. Improvement of the purity by a variety of steps in the purification process is monitored by characterization techniques including SEM, TEM, Raman, UV-VIS-NIR and TGA. A recently established NASA-JSC protocol for SWCNT characterization is undergoing revision with feedback from nanotube community. Efforts at JSC over the past five years in composites have centered on structural polymednanotube systems. Recent activities broadened this focus to multifunctional materials, supercapacitors, fuel cells, regenerable CO2 absorbers, electromagnetic shielding, radiation dosimetry and thermal management systems of interest for human space flight. Preliminary tests indicate improvement of performance in most of these applications because of the large surface area as well as high electrical and thermal conductivity exhibited by SWCNTs.

  4. The Land Processes Distributed Active Archive Center (LP DAAC) (United States)

    Golon, Danielle K.


    The Land Processes Distributed Active Archive Center (LP DAAC) operates as a partnership with the U.S. Geological Survey and is 1 of 12 DAACs within the National Aeronautics and Space Administration (NASA) Earth Observing System Data and Information System (EOSDIS). The LP DAAC ingests, archives, processes, and distributes NASA Earth science remote sensing data. These data are provided to the public at no charge. Data distributed by the LP DAAC provide information about Earth’s surface from daily to yearly intervals and at 15 to 5,600 meter spatial resolution. Data provided by the LP DAAC can be used to study changes in agriculture, vegetation, ecosystems, elevation, and much more. The LP DAAC provides several ways to access, process, and interact with these data. In addition, the LP DAAC is actively archiving new datasets to provide users with a variety of data to study the Earth.

  5. 77 FR 20887 - Proposed Information Collection (National Acquisition Center Customer Response Survey) Activity... (United States)


    ... solicits comments on the information needed to measure customer satisfaction with delivered products and... AFFAIRS Proposed Information Collection (National Acquisition Center Customer Response Survey) Activity...: Department of Veterans Affairs (VA) National Acquisition Center Customer Response Survey, VA Form 0863....

  6. Carbon Dioxide Information Analysis Center: FY 1991 activities

    Energy Technology Data Exchange (ETDEWEB)

    Cushman, R.M.; Stoss, F.W.


    During the course of a fiscal year, Oak Ridge National Laboratory's Carbon Dioxide Information Analysis Center (CDIAC) distributes thousands of specially publications-numeric data packages (NDPs), computer model packages (CMPs), technical reports, public communication publications, newsletters, article reprints, and reference books-in response to requests for information related to global environmental issues, primarily those pertaining to climate change. CDIAC's staff also provides technical responses to specific inquiries related to carbon dioxide (CO{sub 2}), other trace gases, and climate. Hundreds of referrals to other researchers, policy analysts, information specialists, or organizations are also facilitated by CDIAC's staff. This report provides an account of the activities accomplished by CDIAC during the period October 1, 1990 to September 30, 1991. An organizational overview of CDIAC and its staff is supplemented by a detailed description of inquiries received and CDIAC's response to those inquiries. An analysis and description of the preparation and distribution of numeric data packages, computer model packages, technical reports, newsletters, factsheets, specially publications, and reprints is provided. Comments and descriptions of CDIAC's information management systems, professional networking, and special bilateral agreements are also described.

  7. Carbon Dioxide Information Analysis Center: FY 1991 activities

    Energy Technology Data Exchange (ETDEWEB)

    Cushman, R.M.; Stoss, F.W.


    During the course of a fiscal year, Oak Ridge National Laboratory`s Carbon Dioxide Information Analysis Center (CDIAC) distributes thousands of specially publications-numeric data packages (NDPs), computer model packages (CMPs), technical reports, public communication publications, newsletters, article reprints, and reference books-in response to requests for information related to global environmental issues, primarily those pertaining to climate change. CDIAC`s staff also provides technical responses to specific inquiries related to carbon dioxide (CO{sub 2}), other trace gases, and climate. Hundreds of referrals to other researchers, policy analysts, information specialists, or organizations are also facilitated by CDIAC`s staff. This report provides an account of the activities accomplished by CDIAC during the period October 1, 1990 to September 30, 1991. An organizational overview of CDIAC and its staff is supplemented by a detailed description of inquiries received and CDIAC`s response to those inquiries. An analysis and description of the preparation and distribution of numeric data packages, computer model packages, technical reports, newsletters, factsheets, specially publications, and reprints is provided. Comments and descriptions of CDIAC`s information management systems, professional networking, and special bilateral agreements are also described.

  8. Carbon Dioxide Information Analysis Center: FY 1992 activities

    Energy Technology Data Exchange (ETDEWEB)

    Cushman, R.M. [Oak Ridge National Lab., TN (United States). Carbon Dioxide Information Analysis Center; Stoss, F.W. [Tennessee Univ., Knoxville, TN (United States). Energy, Environment and Resources Center


    During the course of a fiscal year, Oak Ridge National Laboratory`s Carbon Dioxide Information Analysis Center (CDIAC) distributes thousands of specialty publications-numeric data packages (NDPs), computer model packages (CMPs), technical reports, public communication publications, newsletters, article reprints, and reference books-in response to requests for information related to global environmental issues, primarily those pertaining to climate change. CDIACs staff also provides technical responses to specific inquiries related to carbon dioxide (CO{sub 2}), other trace gases, and climate. Hundreds of referrals to other researchers, policy analysts, information specialists, or organizations are also facilitated by CDIAC`s staff. This report provides an account of the activities accomplished by CDIAC during the period October 1, 1991 to September 30, 1992. An organizational overview of CDIAC and its staff is supplemented by a detailed description of inquiries received and CDIAC`s response to those inquiries. As analysis and description of the preparation and distribution of numeric data packages, computer model packages, technical reports, newsletters, fact sheets, specialty publications, and reprints is provided. Comments and descriptions of CDIAC`s information management systems, professional networking, and special bilateral agreements are also described.

  9. Activities and Products at IVS combination center at BKG (United States)

    Bachmann, S.; Lösler, M.


    The IVS combination center is primarily responsible to provide rapid EOP products based on observation campaigns twice a week and a long-term EOP series which is updated four times a year. Besides EOP products, methods and analysis of combined station coordinates and source positions are evolving and new products are developed in order to expand the range of combined VLBI products. Within the last year the combination center continuously worked on several improvements and refinements of the combination procedure: outlier test have been improved, the detection of unsuitable sessions in order to improve the stability of the results, the modeling of station coordinates of the reference frame generation and the data presentation on the combination centers website. Besides the routine combination of 24h VLBI sessions, several other projects have been developed, e.g. the preparation of the latest VLBI reference frame (VTRF) including the calculation of station height variations and baseline lengths generation derived by the combination of station coordinates. The combination center is furthermore intensely working on the combination of source coordinates and on providing user friendly online analysis tools on the combination centers website in order to meet the user requirements.

  10. Activation of chalcogens and chalcogenides at reactive uranium centers

    Energy Technology Data Exchange (ETDEWEB)

    Franke, Michael Sebastian


    The high reactivity of many trivalent uranium complexes was investigated in the Meyer group, however, these studies were not limited to small-molecule activation, but were extended to other relatively inert reagents like the heavier elemental chalcogens sulfur, selenium, and tellurium. The tripodal N-anchored chelate ({sup Ad,Me}ArO){sub 3}N{sup 3-} (trianion of tris(3-Adamantyl-2-hydroxy-5-methylbenzyl)amine) was found to be a very suitable candidate for this task and the respective uranium(III) complex [(({sup Ad,Me}ArO){sub 3}N)U{sup III}(DME)] is able to activate elemental sulfur and selenium to form the dinuclear, chalcogenido-bridged complexes [{(("A"d","M"eArO)_3N)U"I"V(DME)}{sub 2}(μ-E)] (E = S, Se). Starting from this previously accomplished work, research in this thesis aimed at furthering reactivity studies of trivalent [(({sup Ad,Me}ArO){sub 3}N)U{sup III}(DME)], but also its chalcogenido-bridged uranium(IV) products, and the spectroscopic characterization of all newly synthesized compounds. Furthermore, the development of the new phenol HOAr* (Ar* = 2,6-(CHPh{sub 2}){sub 2}-4-Me-C{sub 6}H{sub 2}, 2,6-bis(diphenylmethyl)-4-methylphenyl) and its establishment as a ligand to be used for uranium coordination chemistry was another goal of this thesis. The activation of CO{sub 2} by uranium(III) complex [(({sup Ad,Me}ArO){sub 3}N)U{sup III}(DME)] to yield the dinuclear, carbonate-bridged uranium(IV/IV) complex [{(("A"d","M"eArO)_3N)U"I"V(DME)}{sub 2}(μ-κ{sup 1}:κ{sup 2}-CO{sub 3})] and CO was reported in 2010 by Meyer and co-workers. These previous results led to the pursuit of the isolation of mixed chalcogenocarbonate complexes from the reaction of the bridging chalcogenidos [{(("A"d","M"eArO)_3N)U"I"V(DME)}{sub 2}(μ-E)] (E = S, Se) with either CO{sub 2} or its heterocumulene analogs COS or CS{sub 2}. The chalcogeno-carbonates [{(("A"d","M"eArO)_3N)U"I"V(DME)}{sub 2}(μ-κ{sup 1}:κ{sup 2}-CO{sub 2}E)] und [{(("A"d","M"eArO)_3N)U"I"V-(DME)}{sub 2}(

  11. Aerospace Battery Activities at NASA/Goddard Space Flight Center (United States)

    Rao, Gopalakrishna M.


    Goddard Space Flight Center has "pioneered" rechargeable secondary battery design, test, infusion and in-orbit battery management among NASA installations. Nickel cadmium batteries of various designs and sizes have been infused for LEO, GEO and Libration Point spacecraft. Nickel-Hydrogen batteries have currently been baselined for the majority of our missions. Li-Ion batteries from ABSL, JSB, SaFT and Lithion have been designed and tested for aerospace application.

  12. User-centered support to localized activities in ubiquitous computing environments


    Pinto, Helder; José, Rui


    The design of pervasive and ubiquitous computing systems must be centered on users’ activity in order to bring computing systems closer to people. The adoption of an activity-centered approach to the design of pervasive and ubiquitous computing systems should consider: a) how humans naturally accomplish an activity; and b) how computing artifacts from both the local and personal domains should contribute to the accomplishment of an activity. This work particularly focuses on localized a...

  13. Classroom Activities: Simple Strategies to Incorporate Student-Centered Activities within Undergraduate Science Lectures. (United States)

    Lom, Barbara


    The traditional science lecture, where an instructor delivers a carefully crafted monolog to a large audience of students who passively receive the information, has been a popular mode of instruction for centuries. Recent evidence on the science of teaching and learning indicates that learner-centered, active teaching strategies can be more effective learning tools than traditional lectures. Yet most colleges and universities retain lectures as their central instructional method. This article highlights several simple collaborative teaching techniques that can be readily deployed within traditional lecture frameworks to promote active learning. Specifically, this article briefly introduces the techniques of: reader's theatre, think-pair-share, roundtable, jigsaw, in-class quizzes, and minute papers. Each technique is broadly applicable well beyond neuroscience courses and easily modifiable to serve an instructor's specific pedagogical goals. The benefits of each technique are described along with specific examples of how each technique might be deployed within a traditional lecture to create more active learning experiences.

  14. Recent Activities on the Embrace Space Weather Regional Warning Center: the New Space Weather Data Center (United States)

    Denardini, Clezio Marcos; Dal Lago, Alisson; Mendes, Odim; Batista, Inez S.; SantAnna, Nilson; Gatto, Rubens; Takahashi, Hisao; Costa, D. Joaquim; Banik Padua, Marcelo; Campos Velho, Haroldo


    On August 2007 the National Institute for Space Research started a task force to develop and operate a space weather program, which is known by the acronyms Embrace that stands for the Portuguese statement "Estudo e Monitoramento BRAasileiro de Clima Espacial" Program (Brazilian Space Weather Study and Monitoring program). The mission of the Embrace/INPE program is to monitor the Solar-Terrestrial environment, the magnetosphere, the upper atmosphere and the ground induced currents to prevent effects on technological and economic activities. The Embrace/INPE system monitors the physical parameters of the Sun-Earth environment, such as Active Regions (AR) in the Sun and solar radiation by using radio telescope, Coronal Mass Ejection (CME) information by satellite and ground-based cosmic ray monitoring, geomagnetic activity by the magnetometer network, and ionospheric disturbance by ionospheric sounders and using data collected by four GPS receiver network, geomagnetic activity by a magnetometer network, and provides a forecasting for Total Electronic Content (TEC) - 24 hours ahead - using a version of the SUPIM model which assimilates the two latter data using nudging approach. Most of these physical parameters are daily published on the Brazilian space weather program web portal, related to the entire network sensors available. Regarding outreach, it has being published a daily bulletin in Portuguese and English with the status of the space weather environment on the Sun, the Interplanetary Medium and close to the Earth. Since December 2011, all these activities are carried out at the Embrace Headquarter, a building located at the INPE's main campus. Recently, a comprehensive data bank and an interface layer are under commissioning to allow an easy and direct access to all the space weather data collected by Embrace through the Embrace web Portal. The information being released encompasses data from: (a) the Embrace Digisonde Network (Embrace DigiNet) that monitors

  15. [Activities of Goddard Earth Sciences and Technology Center, Maryland University (United States)


    The Goddard Space Flight Center (GSFC) is recognized as a world leader in the application of remote sensing and modeling aimed at improving knowledge of the Earth system. The Goddard Earth Sciences Directorate plays a central role in NASA's Earth Observing System and the U.S. Global Change Research Program. Goddard Earth Sciences and Technology (GEST) is organized as a cooperative agreement with the GSFC to promote excellence in the Earth sciences, and is a consortium of universities and corporations (University of Maryland Baltimore County, Howard University, Hampton University, Caelum Research Corporation and Northrop Grumman Corporation). The aim of this new program is to attract and introduce promising students in their first or second year of graduate studies to Oceanography and Earth system science career options through hands-on instrumentation research experiences on coastal processes at NASA's Wallops Flight Facility on the Eastern Shore of Virginia.

  16. Solid state laser employing diamond having color centers as a laser active material

    Energy Technology Data Exchange (ETDEWEB)

    Rand, S.C.; De Shazer, L.G.


    A laser is described comprising: resonant cavity means for supporting coherent radiation; a diamond containing color centers as a laser active material; means for exciting the color centers to emit coherent radiation; and optical path means for providing an exit path for the radiation from the resonant cavity means.

  17. Social Inequalities in Body Weight and Physical Activity: Exploring the Role of Fitness Centers (United States)

    McLaren, Lindsay; Rock, Melanie J.; McElgunn, Jamie


    Fitness centers are a viable option for physical activity, particularly in climates with significant weather variation. Due to variation in economic and social expressions of exclusivity, fitness centers may have some relation to social inequalities in physical inactivity and related health outcomes; thus, our objective was to explore this…

  18. Recent developments centered on orally active iron chelators

    Directory of Open Access Journals (Sweden)

    Robert Hider


    Full Text Available Over the past twenty years there has been a growing interest in the orally active iron chelators, deferiprone and deferasirox, both have been extensively studied. The ability of these compounds to mobilize iron from the heart and endocrine tissue has presented the clinician with some advantages over desferrioxamine, the first therapeutic iron chelator. Other orally active iron chelators are currently under development. The critical features necessary for the design of therapeutically useful orally active iron chelators are presented in this review, together with recent studies devoted to the design of such chelators. This newly emerging range of iron chelators will enable clinicians to apply iron chelation methodology to other disease states and to begin to design personalized chelation regimes.

  19. A New Perspective on the Radio Active Zone at The Galactic Center - Feedback from Nuclear Activities

    CERN Document Server

    Zhao, Jun-Hui; Goss, W M


    Based on our deep image of Sgr A using broadband data observed with the Jansky VLA at 6 cm, we present a new perspective of the radio bright zone at the Galactic center. We further show the radio detection of the X-ray Cannonball, a candidate neutron star associated with the Galactic center SNR Sgr A East. The radio image is compared with the Chandra X-ray image to show the detailed structure of the radio counterparts of the bipolar X-ray lobes. The bipolar lobes are likely produced by the winds from the activities within Sgr A West, which could be collimated by the inertia of gas in the CND, or by the momentum driving of Sgr A*; and the poloidal magnetic fields likely play an important role in the collimation. The less-collimated SE lobe, in comparison to the NW one, is perhaps due to the fact that the Sgr A East SN might have locally reconfigured the magnetic field toward negative galactic latitudes. In agreement with the X-ray observations, the time-scale of ~ $1\\times10^4$ yr estimated for the outermost r...

  20. Robotics-Centered Outreach Activities: An Integrated Approach (United States)

    Ruiz-del-Solar, Javier


    Nowadays, universities are making extensive efforts to attract prospective students to the fields of electrical, electronic, and computer engineering. Thus, outreach is becoming increasingly important, and activities with schoolchildren are being extensively carried out as part of this effort. In this context, robotics is a very attractive and…

  1. Beyond active learning: a case study of teaching practices in an occupation-centered curriculum. (United States)

    Hooper, Barbara


    Although occupation-centered curricula are highly promoted, the teaching processes that convey such designs remain unclear. This case study elucidated occupation-centered teaching practices. Interview and observational data were collected over 8 weeks, and analysis involved coding transcriptions, data matrices, concept maps, journaling, and writing. Participants augmented active learning strategies with strategies that linked course topics to the subject of occupation. The use of linking strategies suggested that: (a) course content was treated as two-tiered; (b) neither content nor instructional processes were inherently occupation-centered; and (c) subject-centered education strengthens social learning theories. Although curricula may appear occupation-centered based on a curriculum description and course content, ultimately "linking opportunities" in the classroom constitute an essential feature that demarcates a program as occupation-centered.

  2. Joint research center activity in thermonuclear fusion technology

    Energy Technology Data Exchange (ETDEWEB)

    Casini, G.; Rocco, P. (Commission of the European Communities, Ispra (Italy). Joint Research Centre)


    A review of the activities in progress in the field of thermonuclear fusion technology at the Joint Research Centre of the European Communities is presented. The research areas are: (I) reactor studies, including conceptual design studies of experimental Tokamak reactors (INTOR/NET) and safety analyses; (II) experimental investigation on first wall and blanket materials and components. Emphasis has been given to those topics which are not reported in detail in the following articles of the issue.

  3. The Activities at World Data Center for Geomagnetism Mumbai, India

    Directory of Open Access Journals (Sweden)

    M Doiphode


    Full Text Available The World Data Centre for Geomagnetism, Mumbai has functioned as a division of the Indian Institute of Geomagnetism, Navi Mumbai since its full fledged activities commenced in 1991 in coordination with the International Council of Scientific Unions (ICSU Panel on World Data Centres. Responsibility for the compilation of final hourly absolute values from nine of the Indian magnetic observatories and deposition of this data to the World Data Centres is undertaken at the centre. We have utilized the full advantage of technology advancement in upgrading our data preservation and conservation policy at various levels. In recent years, the centre has prioritized its activities related to digital preservation to ensure digital archiving of magnetic data from the traditional media and also digital conservation of very old hand written/printed data volumes and magnetograms. In view of the scientific importance of data from the Colaba-Alibag Magnetic Observatory, old magnetograms and data volumes are being converted to digital images for long term preservation. In the digital preservation process, the creation of metadata has become an important component in storing information related to old and current scientific records for future use. The centre also hosts a database driven website to make datasets available online to the global scientific community.


    Institute of Scientific and Technical Information of China (English)

    Le-tian Zhang; Zhi-qiang Fan; Zhi-sheng Fu


    Distribution of active centers(ACD)of ethylene or 1-hexene homopolymerization and ethylene-1-hexene copolymerization with a MgCl2/TiCl4 type Z-N catalyst were studied by deconvolution of the polymer molecular weight distribution into multiple Flory components.Each Flory component is thought to be formed by a certain type of active center.ACD of ethylene-1-hexene copolymer with very low 1-hexene incorporation was compared with that of ethylene homopolymer to see the effect of introducing a-olefin on ethylene polymerization.On the other hand.ACD of ethylene-1-hexene copolymer with very low ethylene incorporation was compared with that of 1-hexene homopolymer.Adding small amount of 1-hexene in ethylene polymerization caused marked activation of all the Flory components of the which the low molecular weight components are activated more than the high molecular weight components.In 1-hexene polymerization system,the activity can also be greatly enhanced by introducing small amount of ethylene.but the different Flory components(or active centers) are activated with similar extent,except a newly emerged active center producing polymer with the lowest molecular weight.The total number of active centers is markedly increased by adding small amount of ethylene in 1-hexene polymerization,but the average catalysis efficiency of the active centers decreased.The broad composition distribution of the ethylene-1-hexene copolymer Can be well understood from the ACD of catalyst and is dependence on the monomer.

  5. Carbon Dioxide Information Analysis Center and World Data Center-A for atmospheric trace gases: FY 1993 activities

    Energy Technology Data Exchange (ETDEWEB)

    Cushman, R.M. [Oak Ridge National Lab., TN (United States). Carbon Dioxide Information Analysis Center; Stoss, F.W. [Oak Ridge National Lab., TN (United States). Carbon Dioxide Information Analysis Center]|[Univ. of Tennessee, Knoxville, TN (United States). Energy, Environment, and Resources Center


    During the course of a fiscal year, Oak Ridge National Laboratory`s Carbon Dioxide Information Analysis Center (CDIAC) distributes thousands of specialty publications-numeric data packages (NDPs), computer model packages (CMPs), technical reports, public communication publications, newsletters, article reprints, and reference books-in response to requests for information related to global environmental issues, primarily those pertaining to climate change. CDIAC`s staff also provide technical responses to specific inquiries related to carbon dioxide (CO{sub 2}), other trace gases, and climate. Hundreds of referrals to other researchers, policy analysts, information specialists, or organizations are also facilitated by CDIAC`s staff. This report provides an account of the activities accomplished by CDIAC (including World Data Center-A for Atmospheric Trace Gases) during the period October 1, 1992, to September 30, 1993. An organizational overview of CDIAC and its staff is supplemented by a detailed description of inquiries received and CDIAC`s response to those inquiries. An analysis and description of the preparation and distribution of NDPS, CMPS, technical reports, newsletters, fact sheets, specialty publications, and reprints are provided. Comments and descriptions of CDIAC`s information management systems, professional networking, and special bilateral agreements are also presented.


    Energy Technology Data Exchange (ETDEWEB)

    Nakashima, S.; Nobukawa, M.; Uchida, H.; Tanaka, T.; Tsuru, T. G.; Koyama, K. [Department of Physics, Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502 (Japan); Murakami, H. [Department of Information Science, Faculty of Liberal Arts, Tohoku Gakuin University 2-1-1 Tenjinzawa, Izumi-ku, Sendai, Miyagi 981-3193 (Japan); Uchiyama, H., E-mail: [Science Education, Faculty of Education, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529 (Japan)


    We report Suzaku results for soft X-ray emission to the south of the Galactic center (GC). The emission (hereafter {sup G}C South{sup )} has an angular size of {approx}42' Multiplication-Sign 16' centered at (l, b) {approx} (0. Degree-Sign 0, - 1. Degree-Sign 4) and is located in the largely extended Galactic ridge X-ray emission (GRXE). The X-ray spectrum of GC South exhibits emission lines from highly ionized atoms. Although the X-ray spectrum of the GRXE can be well fitted with a plasma in collisional ionization equilibrium (CIE), that of GC South cannot be fitted with a plasma in CIE, leaving hump-like residuals at {approx}2.5 and 3.5 keV, which are attributable to the radiative recombination continua of the K-shells of Si and S, respectively. In fact, GC South spectrum is well fitted with a recombination-dominant plasma model; the electron temperature is 0.46 keV while atoms are highly ionized (kT = 1.6 keV) in the initial epoch, and the plasma is now in a recombining phase at a relaxation scale (plasma density Multiplication-Sign elapsed time) of 5.3 Multiplication-Sign 10{sup 11} s cm{sup -3}. The absorption column density of GC South is consistent with that toward the GC region. Thus, GC South is likely to be located in the GC region ({approx}8 kpc distance). The size of the plasma, the mean density, and the thermal energy are estimated to be {approx}97 pc Multiplication-Sign 37 pc, 0.16 cm{sup -3}, and 1.6 Multiplication-Sign 10{sup 51} erg, respectively. We discuss possible origins of the recombination-dominant plasma as a relic of past activity in the GC region.

  7. Can a Satellite Galaxy Merger Explain the Active Past of the Galactic Center?

    CERN Document Server

    Lang, Meagan; Bogdanovic, Tamara; Amaro-Seoane, Pau; Sesana, Alberto


    Observations of the Galactic Center (GC) have accumulated a multitude of "forensic" evidence indicating that several million years ago the center of the Milky Way galaxy was teaming with starforming and accretion-powered activity -- this paints a rather different picture from the GC as we understand it today. We examine a possibility that this epoch of activity could have been triggered by the infall of a satellite galaxy into the Milky Way which began at the redshift of 10 and ended few million years ago with a merger of the Galactic supermassive black hole with an intermediate mass black hole brought in by the inspiralling satellite.

  8. Inhibition of Heme Peroxidase During Phenol Derivatives Oxidation. Possible Molecular Cloaking of the Active Center

    Directory of Open Access Journals (Sweden)

    Juozas Kulys


    Full Text Available Abstract: Ab initio quantum chemical calculations have been applied to the study of the molecular structure of phenol derivatives and oligomers produced during peroxidasecatalyzed oxidation. The interaction of substrates and oligomers with Arthromyces ramosus peroxidase was analyzed by docking methods. The most possible interaction site of oligomers is an active center of the peroxidase. The complexation energy increases with increasing oligomer length. However, the complexed oligomers do not form a precise (for the reaction hydrogen bonding network in the active center of the enzyme. It seems likely that strong but non productive docking of the oligomers determines peroxidase inhibition during the reaction.

  9. Students´ Perspectives on eLearning Activities in Person-Centered, Blended Learning Settings (United States)

    Haselberger, David; Motsching, Renate


    Blended or hybrid learning has become a frequent practice in higher education. In this article our primary research interest was to find out how students perceived eLearning activities in blended learning courses based on the person-centered paradigm. Through analyzing the content of a series of semi-structured interviews we found out that…

  10. Individual Information-Centered Approach for Handling Physical Activity Missing Data (United States)

    Kang, Minsoo; Rowe, David A.; Barreira, Tiago V.; Robinson, Terrance S.; Mahar, Matthew T.


    The purpose of this study was to validate individual information (II)-centered methods for handling missing data, using data samples of 118 middle-aged adults and 91 older adults equipped with Yamax SW-200 pedometers and Actigraph accelerometers for 7 days. We used a semisimulation approach to create six data sets: three physical activity outcome…

  11. The function of the earth observing system - Data information system Distributed Active Archive Centers (United States)

    Lapenta, C. C.


    The functionality of the Distributed Active Archive Centers (DAACs) which are significant elements of the Earth Observing System Data and Information System (EOSDIS) is discussed. Each DAAC encompasses the information management system, the data archival and distribution system, and the product generation system. The EOSDIS DAACs are expected to improve the access to earth science data set needed for global change research.

  12. Nutrition and Physical Activity Practices in Childcare Centers versus Family Childcare Homes (United States)

    Natale, Ruby; Page, Monica; Sanders, Lee


    Obesity rates among preschool-aged children have doubled in the past 10 years, and 60% of these children spend the majority of their day in childcare facilities. Few studies have examined the quality of nutrition and physical activity practices in childcare centers as compared to family childcare homes. The purpose of this study is to determine if…

  13. Research and technology activities at Ames Research Center's Biomedical Research Division (United States)

    Martello, N.


    Various research and technology activities at Ames Research Center's Biomedical Research Division are described. Contributions to the Space Administration's goals in the life sciences include descriptions of research in operational medicine, cardiovascular deconditioning, motion sickness, bone alterations, muscle atrophy, fluid and electrolyte changes, radiation effects and protection, behavior and performance, gravitational biology, and life sciences flight experiments.

  14. Thermal Technology Development Activities at the Goddard Space Flight Center - 2001 (United States)

    Butler, Dan


    This presentation provides an overview of thermal technology development activities carried out at NASA's Goddard Space Flight Center during 2001. Specific topics covered include: two-phase systems (heat pipes, capillary pumped loops, vapor compression systems and phase change materials), variable emittance systems, advanced coatings, high conductivity materials and electrohydrodynamic (EHD) thermal coatings. The application of these activities to specific space missions is also discussed.

  15. The Albano multiple-maar center (Rome, Italy): an active volcanic area since 70 ka (United States)

    Freda, C.; Gaeta, M.; Karner, D. B.; Marra, F.; Renne, P. R.; Scarlato, P.; Taddeucci, J.


    The Albano multiple-maar center hosted the most recent activity of the Alban Hills Volcanic District. The determination of its petrochemical characteristics and its geochronology is therefore of great importance in order to evaluate the status of this volcanic area and to assess the possible volcanic hazard for Rome. Despite the detailed 40Ar/39Ar geochronologic history of the products of its activity, relatively poor information on the stratigraphy and the petrology of this volcanic center exists. In order to develop a detailed chronostratigraphy, petrology, and a more thorough knowledge of the eruptive mechanisms that characterized the recent activity of the Albano center, a joint research project is being conducted by scientists from the Istituto Nazionale di Geofisica e Vulcanologia, the University of California at Berkeley, and the Berkeley Geochronology Center. Here we have studied the most complete stratigraphic section located within the northern crater rim of Albano, where most of the products are exposed. We have investigated proximal and distal outcrops, in order to correlate them to the units identified in the northern crater rim section. We will present our recently acquired geochronologic and petrochemical data, which indicates magma chamber recharge associated with this <70 ka volcanism.

  16. Stathmin regulates microtubule dynamics and microtubule organizing center polarization in activated T cells. (United States)

    Filbert, Erin L; Le Borgne, Marie; Lin, Joseph; Heuser, John E; Shaw, Andrey S


    Polarization of T cells involves reorientation of the microtubule organizing center (MTOC). Because activated ERK is localized at the immunological synapse, we investigated its role by showing that ERK activation is important for MTOC polarization. Suspecting that ERK phosphorylates a regulator of microtubules, we next focused on stathmin, a known ERK substrate. Our work indicates that during T cell activation, ERK is recruited to the synapse, allowing it to phosphorylate stathmin molecules near the immunological synapse. Supporting an important role of stathmin phosphorylation in T cell activation, we showed that T cell activation results in increased microtubule growth rate dependent on the presence of stathmin. The significance of this finding was demonstrated by results showing that CTLs from stathmin(-/-) mice displayed defective MTOC polarization and defective target cell cytolysis. These data implicate stathmin as a regulator of the microtubule network during T cell activation.

  17. Assessment of food, nutrition, and physical activity practices in Oklahoma child-care centers. (United States)

    Sisson, Susan B; Campbell, Janis E; May, Kellie B; Brittain, Danielle R; Monroe, Lisa A; Guss, Shannon H; Ladner, Jennifer L


    The purpose of the current study was to determine the obesogenic practices in all-day child-care centers caring for preschool-aged children. This study used a cross-sectional, self-reported survey mailed to centers across Oklahoma (n=314). Frequency of responses and χ(2) were calculated comparing region and star rating. Items where the majority of centers frequently report best practices include: daily fruits served (76%), daily nonfried vegetables served (71%), rarely/never served sugary drinks (92%), rarely/never used food to encourage good behaviors (88%), staff join children at table most of the time (81%), staff rarely eat different foods in view of children (69%), visible self-serve or request availability of water (93%), regular informal communication about healthy eating (86%), opportunities for outdoor play (95%), not withholding activity for punishment (91%), accessible play equipment (59% to 80% for different types of equipment), and minimization of extended sitting time (78%). Practices where centers can improve include increasing variety of vegetables (18%), reducing frequency of high-fat meats served (74% serve more than once per week), increasing high-fiber and whole-grain foods (35% offer daily), serving style of "seconds" (28% help kids determine whether they are still hungry), nonfood holiday celebrations (44% use nonfood treats), having toys and books that encourage healthy eating (27%) and physical activity (25%) in all rooms in the center, a standard nutrition (21%) and physical education (50%) curriculum, and following a written physical activity policy (43%). Practitioners can use these data to develop benchmarks and interventions, as this was the first study to assess statewide obesogenic practices in child care.

  18. [Activities of voivodeship occupational medicine centers in workplace health promotion in 2008]. (United States)

    Goszczyńska, Eliza


    The paper aims to present the activities of the largest Voivodeship Occupational Medicine Centers (VOMCs) in Poland in the area of workplace health promotion in 2008. It was compiled on the basis of written reports concerning these activities sent by the Centers to the Polish National Center for Workplace Health Promotion, Nofer Institute of Occupational Medicine, Łódź. Their analysis shows a greatly varied level of engagement in and understanding of health promotion--from simple single actions (in the field of health education and screening) to long-running programs, including various ways of influencing people the programs are addressed to. In 2008, there were 78 such programs in the country, the most popular of them were those focused on occupational voice disorders and tobacco smoke). VOMCs perceive external factors, unfavorable or indifferent attitudes towards promoting health of their employees on the part of employers as well as financial constraints, as the most common obstacles in undertaking activities in the field of workplace health promotion. At the same time, they link achievements in this field mostly with their own activities, including effective cooperation with various partners and their well qualified and experienced employees.

  19. Distinct mechanisms for DNA cleavage by myoglobin with a designed heme active center. (United States)

    Zhao, Yuan; Du, Ke-Jie; Gao, Shu-Qin; He, Bo; Wen, Ge-Bo; Tan, Xiangshi; Lin, Ying-Wu


    Heme proteins perform diverse biological functions, of which myoglobin (Mb) is a representative protein. In this study, the O2 carrier Mb was shown to cleave double stranded DNA upon aerobic dithiothreitol-induced reduction, which is fine-tuned by an additional distal histidine, His29 or His43, engineered in the heme active center. Spectroscopic (UV-vis and EPR) and inhibition studies suggested that free radicals including singlet oxygen and hydroxyl radical are responsible for efficient DNA cleavage via an oxidative cleavage mechanism. On the other hand, L29E Mb, with a distinct heme active center involving three water molecules in the met form, was found to exhibit an excellent DNA cleavage activity that was not depending on O2. Inhibition and ligation studies demonstrated for the first time that L29E Mb cleaves double stranded DNA into both the nicked circular and linear forms via a hydrolytic cleavage mechanism, which resembles native endonucleases. This study provides valuable insights into the distinct mechanisms for DNA cleavage by heme proteins, and lays down a base for creating artificial DNA endonucleases by rational design of heme proteins. Moreover, this study suggests that the diverse functions of heme proteins can be fine-tuned by rational design of the heme active center with a hydrogen-bonding network.

  20. PPARγ negatively regulates T cell activation to prevent follicular helper T cells and germinal center formation. (United States)

    Park, Hong-Jai; Kim, Do-Hyun; Choi, Jin-Young; Kim, Won-Ju; Kim, Ji Yun; Senejani, Alireza G; Hwang, Soo Seok; Kim, Lark Kyun; Tobiasova, Zuzana; Lee, Gap Ryol; Craft, Joseph; Bothwell, Alfred L M; Choi, Je-Min


    Peroxisome proliferator-activated receptor gamma (PPARγ) is a transcription factor that regulates lipid and glucose metabolism. Although studies of PPARγ ligands have demonstrated its regulatory functions in inflammation and adaptive immunity, its intrinsic role in T cells and autoimmunity has yet to be fully elucidated. Here we used CD4-PPARγKO mice to investigate PPARγ-deficient T cells, which were hyper-reactive to produce higher levels of cytokines and exhibited greater proliferation than wild type T cells with increased ERK and AKT phosphorylation. Diminished expression of IκBα, Sirt1, and Foxo1, which are inhibitors of NF-κB, was observed in PPARγ-deficient T cells that were prone to produce all the signature cytokines under Th1, Th2, Th17, and Th9 skewing condition. Interestingly, 1-year-old CD4-PPARγKO mice spontaneously developed moderate autoimmune phenotype by increased activated T cells, follicular helper T cells (TFH cells) and germinal center B cells with glomerular inflammation and enhanced autoantibody production. Sheep red blood cell immunization more induced TFH cells and germinal centers in CD4-PPARγKO mice and the T cells showed increased of Bcl-6 and IL-21 expression suggesting its regulatory role in germinal center reaction. Collectively, these results suggest that PPARγ has a regulatory role for TFH cells and germinal center reaction to prevent autoimmunity.

  1. Dust modelling and forecasting in the Barcelona Supercomputing Center: Activities and developments

    Energy Technology Data Exchange (ETDEWEB)

    Perez, C; Baldasano, J M; Jimenez-Guerrero, P; Jorba, O; Haustein, K; Basart, S [Earth Sciences Department. Barcelona Supercomputing Center. Barcelona (Spain); Cuevas, E [Izanaa Atmospheric Research Center. Agencia Estatal de Meteorologia, Tenerife (Spain); Nickovic, S [Atmospheric Research and Environment Branch, World Meteorological Organization, Geneva (Switzerland)], E-mail:


    The Barcelona Supercomputing Center (BSC) is the National Supercomputer Facility in Spain, hosting MareNostrum, one of the most powerful Supercomputers in Europe. The Earth Sciences Department of BSC operates daily regional dust and air quality forecasts and conducts intensive modelling research for short-term operational prediction. This contribution summarizes the latest developments and current activities in the field of sand and dust storm modelling and forecasting.

  2. Societal Values and Policies May Curtail Preschool Children’s Physical Activity in Child Care Centers (United States)

    Sherman, Susan N.; Kendeigh, Cassandra A.; Kalkwarf, Heidi J.; Saelens, Brian E.


    BACKGROUND AND OBJECTIVES: Three-fourths of US preschool-age children are in child care centers. Children are primarily sedentary in these settings, and are not meeting recommended levels of physical activity. Our objective was to identify potential barriers to children’s physical activity in child care centers. METHODS: Nine focus groups with 49 child care providers (55% African American) were assembled from 34 centers (inner-city, suburban, Head Start, and Montessori) in Cincinnati, Ohio. Three coders independently analyzed verbatim transcripts for themes. Data analysis and interpretation of findings were verified through triangulation of methods. RESULTS: We identified 3 main barriers to children’s physical activity in child care: (1) injury concerns, (2) financial, and (3) a focus on “academics.” Stricter licensing codes intended to reduce children's injuries on playgrounds rendered playgrounds less physically challenging and interesting. In addition, some parents concerned about potential injury, requested staff to restrict playground participation for their children. Small operating margins of most child care centers limited their ability to install abundant playground equipment. Child care providers felt pressure from state mandates and parents to focus on academics at the expense of gross motor play. Because children spend long hours in care and many lack a safe place to play near their home, these barriers may limit children's only opportunity to engage in physical activity. CONCLUSIONS: Societal priorities for young children—safety and school readiness—may be hindering children’s physical development. In designing environments that optimally promote children’s health and development, child advocates should think holistically about potential unintended consequences of policies. PMID:22218842

  3. [Activities and responsibilities of workers in embryologic and andrologic laboratories in assisted reproduction centers]. (United States)

    Záková, J; Trávník, P; Malenovská, A; Hűttelová, R


    This paper presents the current status and rules for the laboratory staff activities and their competences in the centers of assisted reproduction. The rules were processed by the members of the Association of Reproductive Embryology (ARE) committee under the current legislation. Committee members of the Czech Sterility and Assisted Reproduction Society and Czech Gynecology and Obstetric Society approved these rules as obligatory for assisted reproduction centres in Czech Republic.

  4. Person-Centered, Physical Activity for Patients with Low Back Pain: Piloting Service Delivery

    Directory of Open Access Journals (Sweden)

    Saul Bloxham


    Full Text Available Low back pain (LBP is one of the most common and costly conditions in industrialized countries. Exercise therapy has been used to treat LBP, although typically using only one mode of exercise. This paper describes the method and initial findings of a person-centered, group physical activity programme which featured as part of a multidisciplinary approach to treating LBP. Six participants (aged 50.7 ± 17 years completed a six-week physical activity programme lasting two hours per week. A multicomponent approach to physical activity was adopted which included aerobic fitness, core activation, muscular strength and endurance, Nordic Walking, flexibility and exercise gaming. In addition, participants were required to use diary sheets to record physical activity completed at home. Results revealed significant (p < 0.05 improvements in back strength (23%, aerobic fitness (23%, negative wellbeing (32% and disability (16%. Person’s Correlation Coefficient analysis revealed significant (p < 0.05 relationships between improvement in perceived pain and aerobic fitness (r = 0.93. It was concluded that a person-centered, multicomponent approach to physical activity may be optimal for supporting patients who self-manage LBP.

  5. The Solar Thermal Design Assistance Center report of its activities and accomplishments in Fiscal Year 1993

    Energy Technology Data Exchange (ETDEWEB)

    Menicucci, D.F.


    The Solar Thermal Design Assistance Center (STDAC) at Sandia National Laboratories is a resource provided by the US Department of Energy`s Solar Thermal Program. Its major objectives are to accelerate the use of solar thermal systems through (a) direct technical assistance to users, (b) cooperative test, evaluation, and development efforts with private industry, and (c) educational outreach activities. This report outlines the major activities and accomplishments of the STDAC in Fiscal Year 1993. The report also contains a comprehensive list of persons who contacted the STDAC by telephone for information or technical consulting.

  6. Activities of the Japanese space weather forecast center at Communications Research Laboratory. (United States)

    Watari, Shinichi; Tomita, Fumihiko


    The International Space Environment Service (ISES) is an international organization for space weather forecasts and belongs to the International Union of Radio Science (URSI). There are eleven ISES forecast centers in the world, and Communications Research Laboratory (CRL) runs the Japanese one. We make forecasts on the space environment and deliver them over the phones and through the Internet. Our forecasts could be useful for human activities in space. Currently solar activity is near maximum phase of the solar cycle 23. We report the several large disturbances of space environment occurred in 2001, during which low-latitude auroras were observed several times in Japan.

  7. Quality-assurance plan for groundwater activities, U.S. Geological Survey, Washington Water Science Center (United States)

    Kozar, Mark D.; Kahle, Sue C.


    This report documents the standard procedures, policies, and field methods used by the U.S. Geological Survey’s (USGS) Washington Water Science Center staff for activities related to the collection, processing, analysis, storage, and publication of groundwater data. This groundwater quality-assurance plan changes through time to accommodate new methods and requirements developed by the Washington Water Science Center and the USGS Office of Groundwater. The plan is based largely on requirements and guidelines provided by the USGS Office of Groundwater, or the USGS Water Mission Area. Regular updates to this plan represent an integral part of the quality-assurance process. Because numerous policy memoranda have been issued by the Office of Groundwater since the previous groundwater quality assurance plan was written, this report is a substantial revision of the previous report, supplants it, and contains significant additional policies not covered in the previous report. This updated plan includes information related to the organization and responsibilities of USGS Washington Water Science Center staff, training, safety, project proposal development, project review procedures, data collection activities, data processing activities, report review procedures, and archiving of field data and interpretative information pertaining to groundwater flow models, borehole aquifer tests, and aquifer tests. Important updates from the previous groundwater quality assurance plan include: (1) procedures for documenting and archiving of groundwater flow models; (2) revisions to procedures and policies for the creation of sites in the Groundwater Site Inventory database; (3) adoption of new water-level forms to be used within the USGS Washington Water Science Center; (4) procedures for future creation of borehole geophysics, surface geophysics, and aquifer-test archives; and (5) use of the USGS Multi Optional Network Key Entry System software for entry of routine water-level data

  8. [Standardization of activities in an oncology surgical center according to nursing intervention classification]. (United States)

    Possari, João Francisco; Gaidzinski, Raquel Rapone; Fugulin, Fernanda Maria Togeiro; Lima, Antônio Fernandes Costa; Kurcgant, Paulina


    This study was undertaken in a surgical center specializing in oncology, and it aimed to identify nursing activities performed during the perioperative period and to classify and validate intervention activities according to the Nursing Interventions Classification (NIC). A survey of activities was conducted using records and by direct observation of nursing care across four shifts. Activities were classified as NIC nursing interventions using the cross-mapping technique. The list of interventions was validated by nursing professionals in workshops. Forty-nine interventions were identified: 34 of direct care and 15 of indirect care. Identifying nursing interventions facilitates measuring the time spent in their execution, which is a fundamental variable in the quantification and qualification of nurses' workloads.

  9. Center for Multiscale Plasma Dynamics: Report on Activities (UCLA/MIT), 2009-2010

    Energy Technology Data Exchange (ETDEWEB)

    Carter, Troy Alan [Univ. of California, Los Angeles, CA (United States)


    The final “phaseout” year of the CMPD ended July 2010; a no cost extension was requested until May 2011 in order to enable the MIT subcontract funds to be fully utilized. Research progress over this time included verification and validation activities for the BOUT and BOUT++ code, studies of spontaneous reconnection in the VTF facility at MIT, and studies of the interaction between Alfv´en waves and drift waves in LAPD. The CMPD also hosted the 6th plasma physics winter school in 2010 (jointly with the NSF frontier center the Center for Magnetic Self-Organization, significant funding came from NSF for this most recent iteration of theWinter School).

  10. Physical activity in child-care centers: do teachers hold the key to the playground? (United States)

    Copeland, Kristen A; Kendeigh, Cassandra A; Saelens, Brian E; Kalkwarf, Heidi J; Sherman, Susan N


    Many (56%) US children aged 3-5 years are in center-based childcare and are not obtaining recommended levels of physical activity. In order to determine what child-care teachers/providers perceived as benefits and barriers to children's physical activity in child-care centers, we conducted nine focus groups and 13 one-on-one interviews with 49 child-care teachers/providers in Cincinnati, OH. Participants noted physical and socio-emotional benefits of physical activity particular to preschoolers (e.g. gross motor skill development, self-confidence after mastery of new skills and improved mood, attention and napping after exercise) but also noted several barriers including their own personal attitudes (e.g. low self-efficacy) and preferences to avoid the outdoors (e.g. don't like hot/cold weather, getting dirty, chaos of playground). Because individual teachers determine daily schedules and ultimately make the decision whether to take the children outdoors, they serve as gatekeepers to the playground. Participants discussed a spectrum of roles on the playground, from facilitator to chaperone to physical activity inhibitor. These findings suggest that children could have very different gross motor experiences even within the same facility (with presumably the same environment and policies), based on the beliefs, creativity and level of engagement of their teacher.

  11. A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers. (United States)

    Zhulyn, Olena; Li, Danyi; Deimling, Steven; Vakili, Niki Alizadeh; Mo, Rong; Puviindran, Vijitha; Chen, Miao-Hsueh; Chuang, Pao-Tien; Hopyan, Sevan; Hui, Chi-chung


    The patterning and growth of the embryonic vertebrate limb is dependent on Sonic hedgehog (Shh), a morphogen that regulates the activity of Gli transcription factors. However, Shh expression is not observed during the first 12 hr of limb development. During this phase, the limb bud is prepatterned into anterior and posterior regions through the antagonistic actions of transcription factors Gli3 and Hand2. We demonstrate that precocious activation of Shh signaling during this early phase interferes with the Gli3-dependent specification of anterior progenitors, disturbing establishment of signaling centers and normal outgrowth of the limb. Our findings illustrate that limb development requires a sweet spot in the level and timing of pathway activation that allows for the Shh-dependent expansion of posterior progenitors without interfering with early prepatterning functions of Gli3/Gli3R or specification of anterior progenitors.

  12. Results of the pilot proof of the inquiry activities conducted in the science center (United States)

    Kireš, Marián; BilišÅanská, Mária


    The science center SteelPARK Košice offers more than 60 interactive exhibits focused on presenting scientific principles and technical solutions connected to the production and manufacture of steel, research of its properties and its various industrial uses. We are trying to enhance the attractivity of the modern style of the exhibitions and its potential to engage students of ground and middle schools in acquiring new knowledge and capabilities, by means of the inquiry science center. Two laboratory measurements, for 5 three-person teams are provided once a month. During the introductory discussion on the activity, they are asked to answer a series of conceptual questions, which help determine their level of understanding at the beginning of the exercise. The measurements are based in guided inquiry, where the work progress is given a forehand, but the desired result is not. Every activity is focused on developing specific research capabilities. This is being monitored through a self-evaluation card, which every participants is required to fill out immediately after completing the activity. The work is tutored by a lecturer from the students of didactics. During two years and running 15 different activities, we have been able to gather information from more than 6000 students of ground and middle schools. Specific physics measurements, their respective conceptual questions, worksheets and final reports are being presented in this article. We evaluate the present level of conceptual understanding based on the acquired data and give recommendation to teachers on ways to improve the student's capabilities. The teacher, by way of observing the activity, the work of the lecturer and the students, is able to form an understanding of the inquiry activity for their own school practice, for which he/she can use all available methodical and work materials.

  13. Clinical process analysis and activity-based costing at a heart center. (United States)

    Ridderstolpe, Lisa; Johansson, Andreas; Skau, Tommy; Rutberg, Hans; Ahlfeldt, Hans


    Cost studies, productivity, efficiency, and quality of care measures, the links between resources and patient outcomes, are fundamental issues for hospital management today. This paper describes the implementation of a model for process analysis and activity-based costing (ABC)/management at a Heart Center in Sweden as a tool for administrative cost information, strategic decision-making, quality improvement, and cost reduction. A commercial software package (QPR) containing two interrelated parts, "ProcessGuide and CostControl," was used. All processes at the Heart Center were mapped and graphically outlined. Processes and activities such as health care procedures, research, and education were identified together with their causal relationship to costs and products/services. The construction of the ABC model in CostControl was time-consuming. However, after the ABC/management system was created, it opened the way for new possibilities including process and activity analysis, simulation, and price calculations. Cost analysis showed large variations in the cost obtained for individual patients undergoing coronary artery bypass grafting (CABG) surgery. We conclude that a process-based costing system is applicable and has the potential to be useful in hospital management.

  14. Substrate activation for O2 reactions by oxidized metal centers in biology. (United States)

    Pau, Monita Y M; Lipscomb, John D; Solomon, Edward I


    The uncatalyzed reactions of O(2) (S = 1) with organic substrates (S = 0) are thermodynamically favorable but kinetically slow because they are spin-forbidden and the one-electron reduction potential of O(2) is unfavorable. In nature, many of these important O(2) reactions are catalyzed by metalloenzymes. In the case of mononuclear non-heme iron enzymes, either Fe(II) or Fe(III) can play the catalytic role in these spin-forbidden reactions. Whereas the ferrous enzymes activate O(2) directly for reaction, the ferric enzymes activate the substrate for O(2) attack. The enzyme-substrate complex of the ferric intradiol dioxygenases exhibits a low-energy catecholate to Fe(III) charge transfer transition that provides a mechanism by which both the Fe center and the catecholic substrate are activated for the reaction with O(2). In this Perspective, we evaluate how the coupling between this experimentally observed charge transfer and the change in geometry and ligand field of the oxidized metal center along the reaction coordinate can overcome the spin-forbidden nature of the O(2) reaction.

  15. Galactic Center gamma-ray ``excess'' from an active past of the Galactic Centre? (United States)

    Petrović, Jovana; Dario Serpico, Pasquale; Zaharijaš, Gabrijela


    Several groups have recently claimed evidence for an unaccounted gamma-ray excess over the diffuse backgrounds at few GeV in the Fermi-LAT data in a region around the Galactic Center, consistent with a dark matter annihilation origin. We demonstrate that the main spectral and angular features of this excess can be reproduced if they are mostly due to inverse Compton emission from high-energy electrons injected in a burst event of ~ 1052÷1053 erg roughly Script O(106) years ago. We consider this example as a proof of principle that time-dependent phenomena need to be understood and accounted for—together with detailed diffuse foregrounds and unaccounted ``steady state'' astrophysical sources—before any robust inference can be made about dark matter signals at the Galactic Center. In addition, we point out that the timescale suggested by our study, which controls both the energy cutoff and the angular extension of the signal, intriguingly matches (together with the energy budget) what is indirectly inferred by other evidences suggesting a very active Galactic Center in the past, for instance related to intense star formation and accretion phenomena.

  16. A University-based Forensics Training Center as a Regional Outreach, Education, and Research activity

    Directory of Open Access Journals (Sweden)

    Rayford B. Vaughn


    Full Text Available This paper describes a university-based Forensics Training Center (FTC established by a Department of Justice grant for the purpose of improving the ability of state and local law enforcement in the Southeastern part of the United States to address the rising incidence of computer based crime. The FTC effort is described along with supporting evidence of its need. The program is not only a service activity, but also contributes to the Mississippi State University (MSU security program pedagogy, and research effort.

  17. A Discourse Analysis of the Centered and Critical Scholar-Activism of Martin Luther King Jr.


    Keatts, Quenton


    The purpose of this project is to investigate the often neglected research concerning the Reverend Dr. Martin Luther King, Jr. and his scholar-activism. This project is intended to look for evidence of intellectual leadership within Kingâ s writings in an effort to classify King within the Scholar-Activist paradigm in Africana Studies. Further, the aim is to examine Martin Luther King, Jr. from the critical and centered Scholar-Activist paradigm of Africana Studies based on an analysis of ...

  18. Spin state transition in the active center of the hemoglobin molecule: DFT + DMFT study (United States)

    Novoselov, D.; Korotin, Dm. M.; Anisimov, V. I.


    An ab initio study of electronic and spin configurations of the iron ion in the active center of the human hemoglobin molecule is presented. With a combination of the Density Functional Theory (DFT) method and the Dynamical Mean Field Theory (DMFT) approach, the spin state transition description in the iron ion during the oxidation process is significantly improved in comparison with previous attempts. It was found that the origin of the iron ion local moment behavior both for the high-spin and for the low-spin states in the hemoglobin molecule is caused by the presence of a mixture of several atomic states with comparable statistical probability.

  19. Discovery of the recombining plasma in the south of the Galactic center; a relic of the past Galactic center activity?

    CERN Document Server

    Nakashima, S; Uchida, H; Tanaka, T; Tsuru, T G; Koyama, K; Murakami, H; Uchiyama, H


    We report Suzaku results for soft X-ray emission to the south of the Galactic center (GC). The emission (hereafter "GC South") has an angular size of ~42' x 16' centered at (l, b) ~ (0.0, -1.4), and is located in the largely extended Galactic ridge X-ray emission (GRXE). The X-ray spectrum of GC South exhibits emission lines from highly ionized atoms. Although the X-ray spectrum of the GRXE can be well fitted with a plasma in collisional ionization equilibrium (CIE), that of GC South cannot be fitted with a plasma in CIE, leaving hump-like residuals at ~2.5 and 3.5 keV, which are attributable to the radiative recombination continua of the K-shells of Si and S, respectively. In fact, GC South spectrum is well fitted with a recombination-dominant plasma model; the electron temperature is 0.46 keV while atoms are highly ionized (kT = 1.6 keV) in the initial epoch, and the plasma is now in a recombining phase at a relaxation scale (plasma density x elapsed time) of 5.3 x 10^11 s cm^-3. The absorption column densi...

  20. Active learning and student-centered pedagogy improve student attitudes and performance in introductory biology. (United States)

    Armbruster, Peter; Patel, Maya; Johnson, Erika; Weiss, Martha


    We describe the development and implementation of an instructional design that focused on bringing multiple forms of active learning and student-centered pedagogies to a one-semester, undergraduate introductory biology course for both majors and nonmajors. Our course redesign consisted of three major elements: 1) reordering the presentation of the course content in an attempt to teach specific content within the context of broad conceptual themes, 2) incorporating active and problem-based learning into every lecture, and 3) adopting strategies to create a more student-centered learning environment. Assessment of our instructional design consisted of a student survey and comparison of final exam performance across 3 years-1 year before our course redesign was implemented (2006) and during two successive years of implementation (2007 and 2008). The course restructuring led to significant improvement of self-reported student engagement and satisfaction and increased academic performance. We discuss the successes and ongoing challenges of our course restructuring and consider issues relevant to institutional change.

  1. Activity-based costing via an information system: an application created for a breast imaging center. (United States)

    Hawkins, H; Langer, J; Padua, E; Reaves, J


    Activity-based costing (ABC) is a process that enables the estimation of the cost of producing a product or service. More accurate than traditional charge-based approaches, it emphasizes analysis of processes, and more specific identification of both direct and indirect costs. This accuracy is essential in today's healthcare environment, in which managed care organizations necessitate responsible and accountable costing. However, to be successfully utilized, it requires time, effort, expertise, and support. Data collection can be tedious and expensive. By integrating ABC with information management (IM) and systems (IS), organizations can take advantage of the process orientation of both, extend and improve ABC, and decrease resource utilization for ABC projects. In our case study, we have examined the process of a multidisciplinary breast center. We have mapped the constituent activities and established cost drivers. This information has been structured and included in our information system database for subsequent analysis.

  2. Grounding Activity in People-Centered Smart Territories by Enhancing Community Awareness

    Directory of Open Access Journals (Sweden)

    John M. Carroll


    Full Text Available Contemporary life can seem rushed and overloaded. We argue this may be due not to merely having too much to do, but rather with experiencing fragmentation and inadequate meaning in one’s own activity. We suggest that a design approach to this challenge is to enhance awareness of significant and persistent activity, and the themes, values, places, and motivations that unifies it and gives it greater meaning. Specifically, we suggest that people-centered smart territories can enhance community awareness by reminding people of placed-based history, heritage, current issues and discussions, and plans for the future in the community through a smart social grid of community information services.

  3. Passivation of electrically active centers by Hydrogen and Lithium in Semiconductors

    CERN Multimedia


    The hyperfine technique of Perturbed Angular Correlation Spectroscopy (PAC) has proven to be excellently suited for the microscopic investigation of impurity complexes in semiconductors. But this method is seriously limited by the small number of chemically different isotopes which are suitable for PAC measurements and represent electrically active centers in semiconductors. This bottleneck can be widely overcome by the ISOLDE facility which provides a great variety of shortliving PAC isotopes. The probe atom $^{111m}$Cd, provided by ISOLDE opened the first successful access to PAC investigations of III-V compounds and enabled also the first PAC experiments on double acceptors in silicon and germamum. \\\\ \\\\ At the new ISOLDE facility our experiments were concentrated on the passivation of electrically active centres by hydrogen and lithium in Si, Ge and III-V compounds. Experiments on $^{111m}$Cd in Ge revealed the formation of two different acceptor hydrogen and two different acceptor lithium complexes respe...

  4. Active-learning versus teacher-centered instruction for learning acids and bases (United States)

    Acar Sesen, Burcin; Tarhan, Leman


    Background and purpose: Active-learning as a student-centered learning process has begun to take more interest in constructing scientific knowledge. For this reason, this study aimed to investigate the effectiveness of active-learning implementation on high-school students' understanding of 'acids and bases'. Sample The sample of this study was 45 high-school students (average age 17 years) from two different classes, which were randomly assigned to the experimental (n = 21) and control groups (n = 25), in a high school in Turkey. Design and methods A pre-test consisting of 25 items was applied to both experimental and control groups before the treatment in order to identify student prerequisite knowledge about their proficiency for learning 'acids and bases'. A one-way analysis of variance (ANOVA) was conducted to compare the pre-test scores for groups and no significant difference was found between experimental (ME = 40.14) and control groups (MC = 41.92) in terms of mean scores (F 1,43 = 2.66, p > 0.05). The experimental group was taught using an active-learning curriculum developed by the authors and the control group was taught using traditional course content based on teacher-centered instruction. After the implementation, 'Acids and Bases Achievement Test' scores were collected for both groups. Results ANOVA results showed that students' 'Acids and Bases Achievement Test' post-test scores differed significantly in terms of groups (F 1,43 = 102.53; p test and individual interview results, it was found that high-school students in the experimental group had fewer misconceptions and understood the concepts more meaningfully than students in control group. Conclusion The study revealed that active-learning implementation is more effective at improving students' learning achievement and preventing misconceptions.

  5. Annual activities report of Brazilian Aerospace Technical Center -CTA/IEAv - 1989; Relatorio anual de atividades - CTA/IEAv - 1989

    Energy Technology Data Exchange (ETDEWEB)



    This document reports the research activities on nuclear physics and reactors physics and engineering in the Brazilian Aerospace Technical Center/Advanced Studies Institute, Sao Paulo State, in the year of 1989.

  6. Ford/BASF/UM Activities in Support of the Hydrogen Storage Engineering Center of Excellence

    Energy Technology Data Exchange (ETDEWEB)

    Veenstra, Mike [Ford Motor Company, Dearborn, MI (United States); Purewal, Justin [Ford Motor Company, Dearborn, MI (United States); Xu, Chunchuan [Ford Motor Company, Dearborn, MI (United States); Yang, Jun [Ford Motor Company, Dearborn, MI (United States); Blaser, Rachel [Ford Motor Company, Dearborn, MI (United States); Sudik, Andrea [Ford Motor Company, Dearborn, MI (United States); Siegel, Don [Univ. of Michigan, Ann Arbor, MI (United States); Ming, Yang [Univ. of Michigan, Ann Arbor, MI (United States); Liu, Dong' an [Univ. of Michigan, Ann Arbor, MI (United States); Chi, Hang [Univ. of Michigan, Ann Arbor, MI (United States); Gaab, Manuela [BASF SE, Ludwigshafen (Germany); Arnold, Lena [BASF SE, Ludwigshafen (Germany); Muller, Ulrich [BASF SE, Ludwigshafen (Germany)


    revealed cost gaps and opportunities that identified a storage system that was lower cost than a 700 bar compressed system. Finally, we led the HSECoE efforts devoted to characterizing and enhancing metal organic framework (MOF) storage materials. This report serves as a final documentation of the Ford-UM-BASF project contributions to the HSECoE during the 6-year timeframe of the Center. The activities of the HSECoE have impacted the broader goals of the DOE-EERE and USDRIVE, leading to improved understanding in the engineering of materials-based hydrogen storage systems. This knowledge is a prerequisite to the development of a commercially-viable hydrogen storage system.

  7. Oregon Model Center--Learning Disabilities: Final Report on Products and Activities, 1973-1975. (United States)

    Calkin, Abigail B.

    Presented are evaluations of eight 1973-75 objectives of the Oregon Model Center for children with learning disabilities. The center was developed to facilitate expansion of the Educational Evaluation Center, a diagnostic-prescriptive center at Oregon College of Education. Among objectives evaluated are: studying the process of the Education…

  8. Home-Type Activities at the Day Care Center. (Tipos De Actividades Del Hogar En El Centro De Cuidado Diario.) (United States)

    Aaronson, May; Moberg, Patricia E.

    This paper argues that home activities comprise a valuable unplanned curriculum and that many of these activities can be transferred to the day care center. It is suggested that these activities foster a closer relationship between child and caregiver and bridge the gap between familiar home environment and novel day care setting. Home activities…

  9. Introducing a 2-His-1-Glu Nonheme Iron Center into Myoglobin Confers Nitric Oxide Reductase Activity

    Energy Technology Data Exchange (ETDEWEB)

    Y Lin; N Yeung; Y Gao; K Miner; L Lei; H Robinson; Y Lu


    A conserved 2-His-1-Glu metal center, as found in natural nonheme iron-containing enzymes, was engineered into sperm whale myoglobin by replacing Leu29 and Phe43 with Glu and His, respectively (swMb L29E, F43H, H64, called Fe{sub B}Mb(-His)). A high resolution (1.65 {angstrom}) crystal structure of Cu(II)-CN{sup -}-Fe{sub B}Mb(-His) was determined, demonstrating that the unique 2-His-1-Glu metal center was successfully created within swMb. The Fe{sub B}Mb(-His) can bind Cu, Fe, or Zn ions, with both Cu(I)-Fe{sub B}Mb(-His) and Fe(II)-Fe{sub B}Mb(-His) exhibiting nitric oxide reductase (NOR) activities. Cu dependent NOR activity was significantly higher than that of Fe in the same metal binding site. EPR studies showed that the reduction of NO to N{sub 2}O catalyzed by these two enzymes resulted in different intermediates; a five-coordinate heme-NO species was observed for Cu(I)-Fe{sub B}Mb(-His) due to the cleavage of the proximal heme Fe-His bond, while Fe(II)-Fe{sub B}Mb(-His) remained six-coordinate. Therefore, both the metal ligand, Glu29, and the metal itself, Cu or Fe, play crucial roles in NOR activity. This study presents a novel protein model of NOR and provides insights into a newly discovered member of the NOR family, gNOR.

  10. Introducing a 2-His-1-Glu Nonheme Iron Center into Myoglobin Confers Nitric Oxide Reductase Activity

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Y.W.; Robinson, H.; Yeung, N.; Gao, Y.-G.; Miner, K. D.; Lei, L.; Lu, Y.


    A conserved 2-His-1-Glu metal center, as found in natural nonheme iron-containing enzymes, was engineered into sperm whale myoglobin by replacing Leu29 and Phe43 with Glu and His, respectively (swMb L29E, F43H, H64, called Fe{sub B}Mb(-His)). A high resolution (1.65 {angstrom}) crystal structure of Cu(II)-CN?-Fe{sub B}Mb(-His) was determined, demonstrating that the unique 2-His-1-Glu metal center was successfully created within swMb. The Fe{sub B}Mb(-His) can bind Cu, Fe, or Zn ions, with both Cu(I)-Fe{sub B}Mb(-His) and Fe(II)-Fe{sub B}Mb(-His) exhibiting nitric oxide reductase (NOR) activities. Cu dependent NOR activity was significantly higher than that of Fe in the same metal binding site. EPR studies showed that the reduction of NO to N{sub 2}O catalyzed by these two enzymes resulted in different intermediates; a five-coordinate heme-NO species was observed for Cu(I)-Fe{sub B}Mb(-His) due to the cleavage of the proximal heme Fe-His bond, while Fe(II)-Fe{sub B}Mb(-His) remained six-coordinate. Therefore, both the metal ligand, Glu29, and the metal itself, Cu or Fe, play crucial roles in NOR activity. This study presents a novel protein model of NOR and provides insights into a newly discovered member of the NOR family, gNOR.

  11. Galactic Center gamma-ray "excess" from an active past of the Galactic Centre?

    CERN Document Server

    Petrovic, Jovana; Zaharijas, Gabrijela


    Several groups have recently claimed evidence for unaccounted gamma-ray excesses over diffuse backgrounds at few GeV in Fermi-LAT data in a region around the Galactic Center, consistent with a dark matter annihilation origin. We demonstrate that the main spectral and angular features of this "excess" can be reproduced if they are mostly due to inverse Compton emission from high-energy electrons injected in a burst event of ~ 10^{52}-10^{53} erg roughly O(10^6) years ago. We consider this example as a proof of principle that time-dependent phenomena need to be understood and accounted for---together with detailed diffuse foregrounds and unaccounted "steady state" astrophysical sources---before any robust inference can be made about dark matter signals at the Galactic Center. In addition, we point out that the timescale suggested by our study, which controls both the energy cutoff and the angular extension of the signal, intriguingly matches what is inferred by other forensic evidences suggesting a very active ...

  12. Functional Magnetic Resonance Imaging of Different Genders in the Activation of Brain Emotional Centers

    Directory of Open Access Journals (Sweden)

    L. Podsiadło


    Full Text Available Background/Objective: The main aim of this study"nwas to reveal gender differences in the localization"nof brain emotional centers for positive and negative"nstimuli."nPatients and Methods: Forty right-handed young"nvolunteers (age range, 18-36 years, 21 men and 19"nwomen were examined using MR 1.5 T Signa Horizon"n(GEMS. Functional images were acquired using a"nspin-echo echoplanar sequence sensitive to blood"noxygenation level dependent (BOLD contrast, with"nthe following parameters: TR=3000 ms, TE= 60 ms,"nFOV=2821 cm, matrix 9696,1 NEX. For emotion induction, affectively negative, positive and neutral"npictures were used. Positive and negative cues were"ntaken from the International Affecive Picture System"n(IAPS. There were two runs, in the first run subjects"nsaw only negatively valenced pictures, during the"nsecond run only positive pictures were shown."nResults: For positive stimuli, the greatest differences"nin activation in women compared to men were"ndetected in the right superior temporal gyrus. For"nnegative stimuli, the greatest differences in activation"nin women compared to men were detected in the left"nthalamus. For positive stimuli, the greatest differences"nin activation in men compared to women were"ndetected in the bilateral occipital lobes as well as the"nbilateral fusiform gyrus. For negative stimuli, the"ngreatest differences in activation in men compared to"nwomen were detected in the left insula."nConclusion: There are statistically significant"ndifferences in activation of the emotional centers"nbetween females and males for the positive and"ndenoised, extracted and visualized. Follow-up CT"nexam and/or clinical pictures confirmed or excluded"nthe diagnosis. Based on preliminary results and"nconcluded efficiency limitations additional postprocessing"nbased on curvelets decomposition and"nimproved segmentation of stroke susceptible regions"nhas been designed and performed later on for selected"nexaminations regarded as

  13. Stereoselective bimolecular phenoxyl radical coupling by an auxiliary (dirigent) protein without an active center

    Energy Technology Data Exchange (ETDEWEB)

    Davin, L.B.; Wang, Huai-Bin; Crowell, A.L. [Washington State Univ., Pullman, WA (United States)] [and others


    The regio- and stereospecificity of bimolecular phenoxy radical coupling reactions, of especial importance in lignin and lignan biosynthesis, are clearly controlled in some manner in vivo; yet in vitro coupling by oxidases, such as laccases, only produce racemic products. In other words, laccases, peroxidases, and comparable oxidases are unable to control regio- or stereospecificity by themselves and thus some other agent must exist. A 78-kilodalton protein has been isolated that, in the presence of an oxidase or one electron oxidant, effects stereoselective bimolecular phenoxy radical coupling in vitro. Itself lacking a catalytically active (oxidative) center, its mechanism of action is presumed to involve capture of E-coniferyl alcohol-derived free-radical intermediates, with consequent stereoselective coupling to give (+)-pinoresinol. 25 refs., 6 figs., 3 tabs.

  14. Bubble mass center and fluid feedback force fluctuations activated by constant lateral impulse with variable thrust (United States)

    Hung, R. J.; Long, Y. T.


    Sloshing dynamics within a partially filled rotating dewar of superfluid helium 2 are investigated in response to constant lateral impulse with variable thrust. The study, including how the rotating bubble of superfluid helium 2 reacts to the constant impulse with variable time period of thrust action in microgravity, how amplitudes of bubble mass center fluctuates with growth and decay of disturbances, and how fluid feedback forces fluctuates in activating on the rotating dewar through the dynamics of sloshing waves are investigated. The numerical computation of sloshing dynamics is based on the non-inertial frame spacecraft bound coordinate with lateral impulses actuating on the rotating dewar in both inertial and non-inertial frames of thrust. Results of the simulations are illustrated.

  15. Analysis of the access patterns at GSFC distributed active archive center (United States)

    Johnson, Theodore; Bedet, Jean-Jacques


    The Goddard Space Flight Center (GSFC) Distributed Active Archive Center (DAAC) has been operational for more than two years. Its mission is to support existing and pre Earth Observing System (EOS) Earth science datasets, facilitate the scientific research, and test Earth Observing System Data and Information System (EOSDIS) concepts. Over 550,000 files and documents have been archived, and more than six Terabytes have been distributed to the scientific community. Information about user request and file access patterns, and their impact on system loading, is needed to optimize current operations and to plan for future archives. To facilitate the management of daily activities, the GSFC DAAC has developed a data base system to track correspondence, requests, ingestion and distribution. In addition, several log files which record transactions on Unitree are maintained and periodically examined. This study identifies some of the users' requests and file access patterns at the GSFC DAAC during 1995. The analysis is limited to the subset of orders for which the data files are under the control of the Hierarchical Storage Management (HSM) Unitree. The results show that most of the data volume ordered was for two data products. The volume was also mostly made up of level 3 and 4 data and most of the volume was distributed on 8 mm and 4 mm tapes. In addition, most of the volume ordered was for deliveries in North America although there was a significant world-wide use. There was a wide range of request sizes in terms of volume and number of files ordered. On an average 78.6 files were ordered per request. Using the data managed by Unitree, several caching algorithms have been evaluated for both hit rate and the overhead ('cost') associated with the movement of data from near-line devices to disks. The algorithm called LRU/2 bin was found to be the best for this workload, but the STbin algorithm also worked well.

  16. Activation Strain Analysis of SN2 Reactions at C, N, O, and F Centers. (United States)

    Kubelka, Jan; Bickelhaupt, F Matthias


    Fundamental principles that determine chemical reactivity and reaction mechanisms are the very foundation of chemistry and many related fields of science. Bimolecular nucleophilic substitutions (SN2) are among the most common and therefore most important reaction types. In this report, we examine the trends in the SN2 reactions with respect to increasing electronegativity of the reaction center by comparing the well-studied backside SN2 Cl(-) + CH3Cl with similar Cl(-) substitutions on the isoelectronic series with the second period elements N, O, and F in place of C. Relativistic (ZORA) DFT calculations are used to construct the gas phase reaction potential energy surfaces (PES), and activation strain analysis, which allows decomposition of the PES into the geometrical strain and interaction energy, is employed to analyze the observed trends. We find that SN2@N and SN2@O have similar PES to the prototypical SN2@C, with the well-defined reaction complex (RC) local minima and a central barrier, but all stationary points are, respectively, increasingly stable in energy. The SN2@F, by contrast, exhibits only a single-well PES with no barrier. Using the activation strain model, we show that the trends are due to the interaction energy and originate mainly from the decreasing energy of the empty acceptor orbital (σ*A-Cl) on the reaction center A in the order of C, N, O, and F. The decreasing steric congestion around the central atom is also a likely contributor to this trend. Additional decomposition of the interaction energy using Kohn-Sham molecular orbital (KS-MO) theory provides further support for this explanation, as well as suggesting electrostatic energy as the primary reason for the distinct single-well PES profile for the FCl reaction.


    Energy Technology Data Exchange (ETDEWEB)

    Schweitzer, Martin [ORNL


    Eight Regional CHP Application Centers (RACs) are funded by the U.S. Department of Energy (DOE) to facilitate the development and deployment of Combined Heat and Power (CHP) technologies in all 50 states. The RACs build end-user awareness by providing CHP-related information to targeted markets through education and outreach; they work with the states and regulators to encourage the creation and adoption of favorable public policies; and they provide CHP users and prospective users with technical assistance and support on specific projects. The RACs were started by DOE as a pilot program in 2001 to support the National CHP Roadmap developed by industry to accelerate deployment of energy efficient CHP technologies (U.S. Combined Heat and Power Association 2001). The intent was to foster a regional presence to build market awareness, address policy issues, and facilitate project development. Oak Ridge National Laboratory (ORNL) has supported DOE with the RAC program since its inception. In 2007, ORNL led a cooperative effort involving DOE and some CHP industry stakeholders to establish quantitative metrics for measuring the RACs accomplishments. This effort incorporated the use of logic models to define and describe key RAC activities, outputs, and outcomes. Based on this detailed examination of RAC operations, potential metrics were identified associated with the various key sectors addressed by the RACs: policy makers; regulatory agencies; investor owned utilities; municipal and cooperative utilities; financiers; developers; and end users. The final product was reviewed by a panel of representatives from DOE, ORNL, RACs, and the private sector. The metrics developed through this effort focus on major RAC activities as well as on CHP installations and related outcomes. All eight RACs were contacted in August 2008 and asked to provide data for every year of Center operations for those metrics on which they kept records. In addition, data on CHP installations and

  18. Overview of the National Atmospheric Release Advisory Center's Urban Research and Development Activities (United States)

    Lundquist, J. K.; Sugiyama, G.; Nasstrom, J.


    This presentation describes the tools and services provided by the National Atmospheric Release Advisory Center (NARAC) at Lawrence Livermore National Laboratory (LLNL) for modeling the impacts of airborne hazardous materials. NARAC provides atmospheric plume modeling tools and services for chemical, biological, radiological, and nuclear airborne hazards. NARAC can simulate downwind effects from a variety of scenarios, including fires, industrial and transportation accidents, radiation dispersal device explosions, hazardous material spills, sprayers, nuclear power plant accidents, and nuclear detonations. NARAC collaborates on radiological dispersion source terms and effects models with Sandia National Laboratories and the U.S. Nuclear Regulatory Commission. NARAC was designated the interim provider of capabilities for the Department of Homeland Security's Interagency Modeling and Atmospheric Assessment Center by the Homeland Security Council in April 2004. The NARAC suite of software tools include simple stand-alone, local-scale plume modeling tools for end-user's computers, and Web- and Internet-based software to access advanced modeling tools and expert analyses from the national center at LLNL. Initial automated, 3-D predictions of plume exposure limits and protective action guidelines for emergency responders and managers are available from the center in 5-10 minutes. These can be followed immediately by quality-assured, refined analyses by 24 x 7 on-duty or on-call NARAC staff. NARAC continues to refine calculations using updated on-scene information, including measurements, until all airborne releases have stopped and the hazardous threats are mapped and impacts assessed. Model predictions include the 3-D spatial and time-varying effects of weather, land use, and terrain, on scales from the local to regional to global. Real-time meteorological data and forecasts are provided by redundant communications links to the U.S. National Oceanic and Atmospheric

  19. Large-Scale Investigation of the Role of Trait Activation Theory for Understanding Assessment Center Convergent and Discriminant Validity (United States)

    Lievens, Filip; Chasteen, Christopher S.; Day, Eric Anthony; Christiansen, Neil D.


    This study used trait activation theory as a theoretical framework to conduct a large-scale test of the interactionist explanation of the convergent and discriminant validity findings obtained in assessment centers. Trait activation theory specifies the conditions in which cross-situationally consistent and inconsistent candidate performances are…

  20. Recovering Physical Activity Missing Data Measured by Accelerometers: A Comparison of Individual and Group-Centered Recovery Methods (United States)

    Zhuang, Jie; Chen, Peijie; Wang, Chao; Jin, Jing; Zhu, Zheng; Zhang, Wenjie


    Purpose: The purpose of this study was to determine which method, individual information-centered (IIC) or group information-centered (GIC), is more efficient in recovering missing physical activity (PA) data. Method: A total of 2,758 Chinese children and youth aged 9 to 17 years old (1,438 boys and 1,320 girls) wore ActiGraph GT3X/GT3X+…

  1. Effects of supported metallocene catalyst active center multiplicity on antioxidant-stabilized ethylene homo- and copolymers

    KAUST Repository

    Atiqullah, Muhammad


    © 2014 Akadémiai Kiadó, Budapest, Hungary. A silica-supported bis(n-butylcyclopentadienyl) zirconium dichloride [( n BuCp)2ZrCl2] catalyst was synthesized. This was used to prepare an ethylene homopolymer and an ethylene-1-hexene copolymer. The active center multiplicity of this catalyst was modeled by deconvoluting the copolymer molecular mass distribution and chemical composition distribution. Five different active site types were predicted, which matched the successive self-nucleation and annealing temperature peaks. The thermo-oxidative melt stability, with and without Irganox 1010 and Irgafos 168, of the above polyethylenes was investigated using nonisothermal differential scanning calorimetric (DSC) experiments at 150 °C. This is a temperature that ensures complete melting of the samples and avoids the diffusivity of oxygen to interfere into polyethylene crystallinity and its thermo-oxidative melt degradation. The oxidation parameters such as onset oxidation temperature, induction period, protection factor, and S-factor were determined by combining theoretical modeling with the DSC experiments. Subsequently, these findings were discussed considering catalyst active center multiplicity and polymer microstructure, particularly average ethylene sequence length. Several insightful results, which have not been reported earlier in the literature, were obtained. The antioxidant effect, for each polymer, varied as (Irganox + Irgafos) ≈ Irganox > Irgafos > Neat polymer. The as-synthesized homopolymer turned out to be almost twice as stable as the corresponding copolymer. The antioxidant(s) in the copolymer showed higher antioxidant effectiveness (AEX) than those in the homopolymer. Irganox exhibited more AEX than Irgafos. To the best of our knowledge, such findings have not been reported earlier in the literature. However, mixed with Irganox or Irgafos, their melt oxidation stability was comparable. The homopolymer, as per the calculated S-factor, showed Irganox


    Directory of Open Access Journals (Sweden)

    Yulia N. KARPOVA


    Full Text Available The article touches upon one of the most acute and complex problems of the modern Russian society the problem of reforming the current system of professional education. The author emphasizes the fact that person – centered and person-activity approach should be the key elements in higher education system modernization as a student personality and his future professional activity should be highlighted in the process of education and upbringing. The author has developed and successfully implemented the integrative language teaching technology, which unites both linguistic and religious knowledge. The article provides a detailed description of the main stages of the process of the technology introduction, the literature and the video materials that were used in the course of the technology implementation in the educational process, as well as formulates conclusions at each stage of its implementation. The effectiveness of the integrative language teaching technology has been proven and is defined by the author as the effect of pedagogical synergy of mutual interaction of several disciplines, characterized by the fact that the influence of the tech nology use exceeds the influence exerted by each discipline as the component of the educational process taken separately.

  3. Cloud Computing Applications in Support of Earth Science Activities at Marshall Space Flight Center (United States)

    Molthan, Andrew L.; Limaye, Ashutosh S.; Srikishen, Jayanthi


    Currently, the NASA Nebula Cloud Computing Platform is available to Agency personnel in a pre-release status as the system undergoes a formal operational readiness review. Over the past year, two projects within the Earth Science Office at NASA Marshall Space Flight Center have been investigating the performance and value of Nebula s "Infrastructure as a Service", or "IaaS" concept and applying cloud computing concepts to advance their respective mission goals. The Short-term Prediction Research and Transition (SPoRT) Center focuses on the transition of unique NASA satellite observations and weather forecasting capabilities for use within the operational forecasting community through partnerships with NOAA s National Weather Service (NWS). SPoRT has evaluated the performance of the Weather Research and Forecasting (WRF) model on virtual machines deployed within Nebula and used Nebula instances to simulate local forecasts in support of regional forecast studies of interest to select NWS forecast offices. In addition to weather forecasting applications, rapidly deployable Nebula virtual machines have supported the processing of high resolution NASA satellite imagery to support disaster assessment following the historic severe weather and tornado outbreak of April 27, 2011. Other modeling and satellite analysis activities are underway in support of NASA s SERVIR program, which integrates satellite observations, ground-based data and forecast models to monitor environmental change and improve disaster response in Central America, the Caribbean, Africa, and the Himalayas. Leveraging SPoRT s experience, SERVIR is working to establish a real-time weather forecasting model for Central America. Other modeling efforts include hydrologic forecasts for Kenya, driven by NASA satellite observations and reanalysis data sets provided by the broader meteorological community. Forecast modeling efforts are supplemented by short-term forecasts of convective initiation, determined by

  4. A parallelogram-based compliant remote-center-of-motion stage for active parallel alignment (United States)

    Qu, Jianliang; Chen, Weihai; Zhang, Jianbin


    Parallel alignment stage with remote-center-of-motion (RCM) is of key importance in precision out-of-plane aligning since it can eliminate the harmful lateral displacement generated at the output platform. This paper presents the development of a parallelogram-based compliant RCM stage for active parallel alignment. Different from conventional parallelogram-based RCM mechanism, the proposed stage is designed with compliant mechanisms, which endows the stage with many attractive merits when used in precision micro-/nanomanipulations. A symmetric double-parallelogram mechanism (SDPM) based on flexure hinges is developed as the rotary guiding component to realize desired RCM function. Due to the geometrical constraint of the SDPM, the operating space of the stage can be easily adjusted by bending the input links without loss of rotational precision. The stage is driven by a piezoelectric actuator and its output motion is measured by non-contact displacement sensors. Based on pseudo-rigid-body simplification method, the analytical models predicting kinematics, statics, and dynamics of the RCM stage have been established. Besides, the dimensional optimization is conducted in order to maximize the first resonance frequency of the stage. After that, finite element analysis is conducted to validate the established models and the prototype of the stage is fabricated for performance tests. The experimental results show that the developed RCM stage has a rotational range of 1.45 mrad while the maximum center shift of the RCM point is as low as 1 μm, which validate the effectiveness of the proposed scheme.

  5. The Evaluation of Bacterial Contamination of Active Radiography Apparatus in Dental Centers of Hamadan City

    Directory of Open Access Journals (Sweden)

    A. Eskandarloo


    Full Text Available Introduction & Objective: During the most dental procedures, contamination of devices with blood, saliva and other body fluids, which is the most important factor for transmission of infectious diseases, is inevitable. Therefore principles of infection control should be carefully considered in the dentistry. The purpose of this study was the evaluation of bacterial contamination of active radiographic apparatus in dental centers of Hamadan city in year 2003. Materials & Methods : In this cross-sectional study 37 radiographic apparatus in dental centers of Hamadan were evaluated. Samples were collected from four area (25 cm2 each that are frequently touched by dentists, personnel, etc. using a swab. The swab was inserted into the carrier media containing thioglycolate, a smear was obtained from the solution and remaining solution was cultured in blood agar. Smear and blood agar cultures were transferred to microbiology lab to determine bacterial contamination level as well as bacterial typing. According to WHO criteria the area which has more than 10 microorganism/cm2 is considered as contaminated. Results: It was found that 13 of radiographic apparatus(35% were contaminated, the most frequent bacterial type detected in this study was micrococcus (75.7% and the least were enterobacter and nocardia (2.7% each. Antiseptic materials used for decontamination of the devices were as follow : Alcohol (43.2% , Deconex (32.4% , Micro10 (18.9% , Savlon (10.8% , Hypochlorid (5.4% , Glutaraldehyde (2.7%. Conclusion: Based on the results (35% bacterial contamination it can be concluded that careful performance of infection control principles, daily decontamination of devices and offering periodic instructions for dental personnel are essential.

  6. Energy characteristics of an F/sup +//sub 2/ center laser and formation of active color centers by a laser beam

    Energy Technology Data Exchange (ETDEWEB)

    Gusev, Y.L.; Kruglov, S.V.; Konoplin, S.N.; Kirpichnikov, A.V.; Marennikov, S.I.


    Lasers operating by means of F/sup +//sub 2/ centers have limited operating time at room temperature because of color center destruction. An efficient and simple method for restoring these centers is described.(AIP)

  7. Integrating Field-Centered, Project Based Activities with Academic Year Coursework: A Curriculum Wide Approach (United States)

    Kelso, P. R.; Brown, L. M.


    Based upon constructivist principles and the recognition that many students are motivated by hands-on activities and field experiences, we designed a new undergraduate curriculum at Lake Superior State University. One of our major goals was to develop stand-alone field projects in most of the academic year courses. Examples of courses impacted include structural geology, geophysics, and geotectonics, Students learn geophysical concepts in the context of near surface field-based geophysical studies while students in structural geology learn about structural processes through outcrop study of fractures, folds and faults. In geotectonics students learn about collisional and rifting processes through on-site field studies of specific geologic provinces. Another goal was to integrate data and samples collected by students in our sophomore level introductory field course along with stand-alone field projects in our clastic systems and sequence stratigraphy courses. Our emphasis on active learning helps students develop a meaningful geoscience knowledge base and complex reasoning skills in authentic contexts. We simulate the activities of practicing geoscientists by engaging students in all aspects of a project, for example: field-oriented project planning and design; acquiring, analyzing, and interpreting data; incorporating supplemental material and background data; and preparing oral and written project reports. We find through anecdotal evidence including student comments and personal observation that the projects stimulate interest, provide motivation for learning new concepts, integrate skill and concept acquisition vertically through the curriculum, apply concepts from multiple geoscience subdisiplines, and develop soft skills such as team work, problem solving, critical thinking and communication skills. Through this projected-centered Lake Superior State University geology curriculum students practice our motto of "learn geology by doing geology."

  8. Development of a national center for hydrogen technology. A summary report of activities completed at the national center hydrogen technology from 2005 to 2010

    Energy Technology Data Exchange (ETDEWEB)

    Holmes, Michael J. [Univ. of North Dakota, Grand Forks, ND (United States)


    The Energy & Environmental Research Center (EERC) located in Grand Forks, North Dakota, has operated the National Center for Hydrogen Technology® (NCHT®) since 2005 under a Cooperative Agreement with the U.S. Department of Energy's (DOE) National Energy Technology Laboratory (NETL). The EERC has a long history of hydrogen generation and utilization from fossil fuels, and under the NCHT Program, the EERC has accelerated its research of hydrogen generation and utilization topics. Since the NCHT's inception, the EERC has received more than $65 million in funding of hydrogen-related projects ($20 million for the NCHT project which includes federal and corporate development partner funds) involving more than 85 partners (27 with the NCHT). The NCHT project's 19 activities span a broad range of technologies that align well with the Advanced Fuels Program goals and, specifically, those described in the Hydrogen from Coal Program research, development, and demonstration (RD&D) plan. A number of projects have been completed which range from technical feasibility of several hydrogen generation and utilization technologies to public and technical education and outreach tools. Projects under the NCHT have produced hydrogen from natural gas, coal, liquid hydrocarbons, and biomass. The hydrogen or syngas generated by these processes has also been purified to transportation-grade quality in many of these instances or burned directly for power generation. Also, several activities are still undergoing research, development, demonstration, and commercialization at the NCHT. This report provides a summary overview of the projects completed in the first 5 years of the NCHT. Individual activity reports are referenced as a source of detailed information on each activity.

  9. Development of a National Center for Hydrogen Technology. A Summary Report of Activities Completed at the National Center for Hydrogen Technology - Year 6

    Energy Technology Data Exchange (ETDEWEB)

    Holmes, Michael [Univ. of North Dakota, Grand Forks, ND (United States)


    The Energy & Environmental Research Center (EERC) located in Grand Forks, North Dakota, has operated the National Center for Hydrogen Technology (NCHT) since 2005 under a Cooperative Agreement with the U.S. Department of Energy (DOE) National Energy Technology Laboratory (NETL). The EERC has a long history of hydrogen generation and utilization from fossil fuels, and under the NCHT Program, the EERC has accelerated its research on hydrogen generation and utilization topics. Since the NCHT's inception, the EERC has received more than $65 million in funding for hydrogen-related projects ($24 million for projects in the NCHT, which includes federal and corporate partner development funds) involving more than 85 partners (27 with the NCHT). The NCHT Program's nine activities span a broad range of technologies that align well with the Advanced Fuels Program goals and, specifically, those described in the Hydrogen from Coal Program research, development, and demonstration (RD&D) plan that refers to realistic testing of technologies at adequate scale, process intensification, and contaminant control. A number of projects have been completed that range from technical feasibility of several hydrogen generation and utilization technologies to public and technical education and outreach tools. Projects under the NCHT have produced hydrogen from natural gas, coal, liquid hydrocarbons, and biomass. The hydrogen or syngas generated by these processes has also been purified in many of these instances or burned directly for power generation. Also, several activities are still undergoing research, development, demonstration, and commercialization at the NCHT. This report provides a summary overview of the projects completed in Year 6 of the NCHT. Individual activity reports are referenced as a source of detailed information on each activity.

  10. Suboptimal B-cell antigen receptor signaling activity in vivo elicits germinal center counterselection mechanisms. (United States)

    Königsberger, Sebastian; Weis, Vanessa; Prodöhl, Jan; Stehling, Martin; Hobeika, Elias; Reth, Michael; Kiefer, Friedemann


    Syk and Zap-70 constitute a closely related nonreceptor protein tyrosine kinase family, of which both members are functionally indispensable for conferring their respective antigen receptors with enzymatic activity. In this study, we analyze the impact of altering BCR signaling output on B-cell germinal center (GC) fate selection by constitutive, as well as inducible, monoallelic Syk kinase loss in the presence of a Zap-70 knock-in rescue allele. Cre-mediated Syk deletion in Syk(flox/Zap-70) B cells lowers pErk, but not pAkt-mediated signaling. Surprisingly, the use of a B-cell-specific constitutive mb1-cre deleter mouse model showed that a small cohort of peripheral Syk(flox/Zap-70);mb1-cre B cells efficiently circumvents deletion, which ultimately favors these Syk-sufficient cells to contribute to the GC reaction. Using a developmentally unbiased Syk(flox/Zap-70);mb1-creER(T2) approach in combination with an inducible tdRFP allele, we further demonstrate that this monoallelic deletion escape is not fully explained by leakiness of Cre expression, but is possibly the result of differential Syk locus accessibility in maturing B cells. Altogether, this underscores the importance of proper Syk kinase function not only during central and peripheral selection processes, but also during GC formation and maintenance.

  11. Bioprocess-centered molecular design (BMD) for the efficient production of an interfacially active peptide. (United States)

    Morreale, Giacomo; Lee, Eun Gyo; Jones, Daniel B; Middelberg, Anton P J


    The efficient expression and purification of an interfacially active peptide (mLac21) was achieved by using bioprocess-centered molecular design (BMD), wherein key bioprocess considerations are addressed during the initial molecular biology work. The 21 amino acid mLac21 peptide sequence is derived from the lac repressor protein and is shown to have high affinity for the oil-water interface, causing a substantial reduction in interfacial tension following adsorption. The DNA coding for the peptide sequence was cloned into a modified pET-31(b) vector to permit the expression of mLac21 as a fusion to ketosteroid isomerase (KSI). Rational iterative molecular design, taking into account the need for a scaleable bioprocess flowsheet, led to a simple and efficient bioprocess yielding mLac21 at 86% purity following ion exchange chromatography (and >98% following chromatographic polishing). This case study demonstrates that it is possible to produce acceptably pure peptide for potential commodity applications using common scaleable bioprocess unit operations. Moreover, it is shown that BMD is a powerful strategy that can be deployed to reduce bioseparation complexity.

  12. Activity of the CNES/CLS Analysis Center for the IDS contribution to ITRF2014 (United States)

    Soudarin, Laurent; Capdeville, Hugues; Lemoine, Jean-Michel


    Within the frame of the International DORIS Service, the CNES/CLS Analysis Center, previously known as LCA and renamed GRG, contributes to the geodetic and geophysical research activity through DORIS data analysis. The main work carried out in the past two years concerns the processing of the measurements collected by the DORIS-equipped satellites over 22 years, in order to provide a homogeneous series of station coordinates and Earth pole parameters for the IDS contribution to the ITRF2014. First, we brought several upgrades to the processing and the modeling. Some of them are corrective actions to issues raised during or shortly after the production of our contribution to the ITRF2008 (ground station frequency offsets, attitude laws and macromodels). Recent models have been assessed with the aim to update our analysis configuration. Among others, we adopted the time variable gravity (TVG) model EIGEN-6S2 and applied tropospheric gradients. Then we processed almost all the DORIS data collected between January 1993 and December 2014. The series of weekly SINEX solutions derived from this processing is labeled grgwd40. This new series performs better than the series produced for ITRF2008. Especially, the results discussed in this paper show a decrease of 2% of the DORIS orbit residuals as well as a strong reduction of the annual terms of the TRF scale and Tz translation which can be explained by the application of the TVG model.

  13. [High activity antiretroviral therapy change associated to adverse drug reactions in a specialized center in Venezuela]. (United States)

    Subiela, José D; Dapena, Elida


    Adverse drug reactions (ADRs) represent the first cause of change of the first-line highly active antiretroviral therapy (HAART) regimen, therefore, they constitute the main limiting factor in the long-term follow up of HIV patients in treatment. A retrospective study was carried out in a specialized center in Lara State, Venezuela, including 99 patients over 18 years of age who had change of first-line HAART regimen due to ADRs, between 2010 and 2013. The aims of this research were to describe the sociodemographic and clinical variables, frequency of ADRs related to change of HAART, duration of the first-line HAART regimen, to determine the drugs associated with ARVs and to identify the risk factors. The ADRs constituted 47.5% of all causes of change of first-line HAART regimen, the median duration was 1.08±0.28 years. The most frequent ADRs were anemia (34.3%), hypersensitivity reactions (20.2%) and gastrointestinal intolerance (13.1%). The most frequent ARV regimen type was the protease inhibitors-based regimen (59.6%), but zidovudine was the ARV most linked to ADRs (41.4%). The regression analysis showed increased risk of ADRs in singles and students in the univariate analysis and heterosexuals and homosexuals in multivariate analysis; and decreased risk in active workers. The present work shows the high prevalence of ADRs in the studied population and represents the first case-based study that describes the pharmacoepidemiology of a cohort of HIV-positive patients treated in Venezuela.

  14. The Student-Centered Active Learning Environment for Undergraduate Programs (SCALE-UP) Project (United States)

    Beichner, Robert J.


    How do you keep a classroom of 100 undergraduates actively learning? Can students practice communication and teamwork skills in a large class? How do you boost the performance of underrepresented groups? The Student-Centered Active Learning Environment for Undergraduate Programs (SCALE-UP) Project has addressed these concerns. Because of their inclusion in a leading introductory physics textbook, project materials are used by more than 1/3 of all science, math, and engineering majors nationwide. The room design and pedagogy have been adopted at more than 100 leading institutions across the country. Physics, chemistry, math, astronomy, biology, engineering, earth sciences, and even literature classes are currently being taught this way. Educational research indicates that students should collaborate on interesting tasks and be deeply involved with the material they are studying. We promote active learning in a redesigned classroom for 100 students or more. (Of course, smaller classes can also benefit.) Class time is spent primarily on "tangibles" and "ponderables"--hands-on activities, simulations, and interesting questions. Nine students sit in three teams at round tables. Instructors circulate and engage in Socratic dialogues. The setting looks like a banquet hall, with lively interactions nearly all the time. Hundreds of hours of classroom video and audio recordings, transcripts of numerous interviews and focus groups, data from conceptual learning assessments (using widely-recognized instruments in a pretest/posttest protocol), and collected portfolios of student work are part of our rigorous assessment effort. Our findings (based on data from over 16,000 students collected over five years as well as replications at adopting sites) can be summarized as the following: 1) Female failure rate is 1/5 of previous levels, even though more is demanded of students. 2) Minority failure rate is 1/4 that seen in traditionally taught courses. 3) At-risk students are more

  15. 34 CFR 350.32 - What activities must a Rehabilitation Engineering Research Center conduct? (United States)


    ... methods of applying advanced technology, scientific achievement, and psychological and social knowledge to... Research Center conduct? 350.32 Section 350.32 Education Regulations of the Offices of the Department of... DISABILITY AND REHABILITATION RESEARCH PROJECTS AND CENTERS PROGRAM What Rehabilitation Engineering...

  16. Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells. (United States)

    Maul, Robert W; Cao, Zheng; Venkataraman, Lakshmi; Giorgetti, Carol A; Press, Joan L; Denizot, Yves; Du, Hansen; Sen, Ranjan; Gearhart, Patricia J


    Variable (V) genes of immunoglobulins undergo somatic hypermutation by activation-induced deaminase (AID) to generate amino acid substitutions that encode antibodies with increased affinity for antigen. Hypermutation is restricted to germinal center B cells and cannot be recapitulated in ex vivo-activated splenic cells, even though the latter express high levels of AID. This suggests that there is a specific feature of antigen activation in germinal centers that recruits AID to V genes which is absent in mitogen-activated cultured cells. Using two Igh knock-in mouse models, we found that RNA polymerase II accumulates in V regions in B cells after both types of stimulation for an extended distance of 1.2 kb from the TATA box. The paused polymerases generate abundant single-strand DNA targets for AID. However, there is a distinct accumulation of the initiating form of polymerase, along with the transcription cofactor Spt5 and AID, in the V region from germinal center cells, which is totally absent in cultured cells. These data support a model where mutations are prevalent in germinal center cells, but not in ex vivo cells, because the initiating form of polymerase is retained, which affects Spt5 and AID recruitment.

  17. "Sticky Ions": A Student-Centered Activity Using Magnetic Models to Explore the Dissolving of Ionic Compounds (United States)

    Ryan, Sheila; Herrington, Deborah G.


    Understanding what happens at the particulate level when ionic compounds dissolve in water is difficult for many students, yet this understanding is critical in explaining many macroscopic observations. This article describes a student-centered activity designed to help strengthen students' conceptual understanding of this process at the…

  18. Attributes of Child Care Centers and Outdoor Play Areas Associated with Preschoolers' Physical Activity and Sedentary Behavior (United States)

    Sugiyama, Takemi; Okely, Anthony D.; Masters, Jane M.; Moore, Gary T.


    This study examined characteristics of child care centers associated with preschoolers' moderate-to-vigorous physical activity and sedentary behavior while in child care (MVPA-C, SB-C), and attributes of outdoor play areas associated with the same behaviors during outdoor time (MVPA-O, SB-O). Participants were 89 children (3 -5 years) recruited…

  19. Department of Energy Support for Operations of the WMO/GAW Quality Control/Science Activity Center for the Americas

    Energy Technology Data Exchange (ETDEWEB)

    Hicks, B. B.


    As a formal activity of the World Meteorological Organization's Global Atmosphere Watch, to provide, through agency collaboration, a center of excellence in the United States that would impose quality assurance techniques on data collected by national air and precipitation quality networks operating in the Americas (north, south, and central).

  20. Efficacy of a Web-Based, Center-Based or Combined Physical Activity Intervention among Older Adults (United States)

    Mouton, Alexandre; Cloes, Marc


    With more social support and environment-centered interventions being recommended in web-based interventions, this study examined the efficacy of three intervention conditions aimed at promoting physical activity (PA) in older adults. The efficacy analyses included the self-reported PA level, stage of change for PA and awareness about PA among…

  1. GOES-R Proving Ground Activities at the NASA Short-Term Prediction Research and Transition (SPoRT) Center (United States)

    Molthan, Andrew


    SPoRT is actively involved in GOES-R Proving Ground activities in a number of ways: (1) Applying the paradigm of product development, user training, and interaction to foster interaction with end users at NOAA forecast offices national centers. (2) Providing unique capabilities in collaboration with other GOES-R Proving Ground partners (a) Hybrid GOES-MODIS imagery (b) Pseudo-GLM via regional lightning mapping arrays (c) Developing new RGB imagery from EUMETSAT guidelines

  2. Web Services Implementations at Land Process and Goddard Earth Sciences Distributed Active Archive Centers (United States)

    Cole, M.; Bambacus, M.; Lynnes, C.; Sauer, B.; Falke, S.; Yang, W.


    NASA's vast array of scientific data within its Distributed Active Archive Centers (DAACs) is especially valuable to both traditional research scientists as well as the emerging market of Earth Science Information Partners. For example, the air quality science and management communities are increasingly using satellite derived observations in their analyses and decision making. The Air Quality Cluster in the Federation of Earth Science Information Partners (ESIP) uses web infrastructures of interoperability, or Service Oriented Architecture (SOA), to extend data exploration, use, and analysis and provides a user environment for DAAC products. In an effort to continually offer these NASA data to the broadest research community audience, and reusing emerging technologies, both NASA's Goddard Earth Science (GES) and Land Process (LP) DAACs have engaged in a web services pilot project. Through these projects both GES and LP have exposed data through the Open Geospatial Consortiums (OGC) Web Services standards. Reusing several different existing applications and implementation techniques, GES and LP successfully exposed a variety data, through distributed systems to be ingested into multiple end-user systems. The results of this project will enable researchers world wide to access some of NASA's GES & LP DAAC data through OGC protocols. This functionality encourages inter-disciplinary research while increasing data use through advanced technologies. This paper will concentrate on the implementation and use of OGC Web Services, specifically Web Map and Web Coverage Services (WMS, WCS) at GES and LP DAACs, and the value of these services within scientific applications, including integration with the DataFed air quality web infrastructure and in the development of data analysis web applications.

  3. Cholecystokinin activation of central satiety centers changes seasonally in a mammalian hibernator. (United States)

    Otis, Jessica P; Raybould, Helen E; Carey, Hannah V


    Hibernators that rely on lipids during winter exhibit profound changes in food intake over the annual cycle. The mechanisms that regulate appetite changes in seasonal hibernators remain unclear, but likely consist of complex interactions between gut hormones, adipokines, and central processing centers. We hypothesized that seasonal changes in the sensitivity of neurons in the nucleus tractus solitarius (NTS) to the gut hormone cholecystokinin (CCK) may contribute to appetite regulation in ground squirrels. Spring (SPR), late summer (SUM), and winter euthermic hibernating (HIB) 13-lined ground squirrels (Ictidomys tridecemlineatus) were treated with intraperitoneal CCK (100 μg/kg) or vehicle (CON) for 3h and Fos expression in the NTS was quantified. In CON squirrels, numbers of Fos-positive neurons in HIB were low compared to SPR and SUM. CCK treatment increased Fos-positive neurons in the NTS at the levels of the area postrema (AP) and pre AP during all seasons and at the level of the rostral AP in HIB squirrels. The highest absolute levels of Fos-positive neurons were found in SPR CCK squirrels, but the highest relative increase from CON was found in HIB CCK squirrels. Fold-changes in Fos-positive neurons in SUM were intermediate between SPR and HIB. Thus, CCK sensitivity falls from SPR to SUM suggesting that seasonal changes in sensitivity of NTS neurons to vagally-derived CCK may influence appetite in the active phase of the annual cycle in hibernating squirrels. Enhanced sensitivity to CCK signaling in NTS neurons of hibernators indicates that changes in gut-brain signaling may contribute to seasonal changes in food intake during the annual cycle.

  4. Evaluation of recombinant activated protein C for severe sepsis at a tertiary academic medical center

    Directory of Open Access Journals (Sweden)

    Anger KE


    Full Text Available Kevin E Anger,1 Jeremy R DeGrado,1 Bonnie C Greenwood,1 Steven A Cohen,2 Paul M Szumita1 1Department of Pharmacy, Brigham and Women’s Hospital, Boston, MA, USA; 2Department of Family Medicine and Population Health, Division of Epidemiology, Virginia Commonwealth University, Richmond, VA, USA Purpose: Early clinical trials of recombinant human activated protein C (rhAPC for severe sepsis excluded patients at high risk of bleeding. Recent literature suggests bleeding rates are higher in clinical practice and may be associated with worsened outcomes. Our objective was to evaluate baseline demographics; incidence, and risk factors for major bleeding; and mortality of patients receiving rhAPC for severe sepsis at our institution. Methods: A retrospective study was performed for all patients receiving rhAPC for treatment of severe sepsis at a tertiary academic medical center from January 2002 to June 2009. Demographic information, clinical variables, intensive care unit, and hospital outcomes were recorded. Results: Of the 156 patients that received rhAPC, 54 (34.6% did not meet institutional criteria for safe use at baseline due to bleeding precaution or contraindication. Twenty-three (14.7% patients experienced a major bleeding event. Multivariate analysis demonstrated baseline International Normalized Ratio ≥2.5 (odds ratio [OR] 3.68, 95% confidence interval [CI]: 1.28–10.56; P = 0.03 and platelet count ≤100 × 103/mm3 (OR 2.86, 95% CI: 1.07–7.67; P = 0.01 as significant predictors of a major bleed. Overall hospital mortality was 57.7%. Multivariate analysis demonstrated the presence of ≥3 organ dysfunctions (OR 2.46, 95% CI: 1.19–5.09; P < 0.05 and medical intensive care unit admission (OR 1.99, 95% CI: 1.00–3.98; P = 0.05 were independent variables associated with hospital mortality. Conclusion: Patients receiving rhAPC at our institution had higher APACHE II scores, mortality, and major bleeding events than published

  5. The effect of total solar eclipse on the daily activities of Nasalis larvatus (Wurmb.) in Mangrove Center, Kariangau, East Kalimantan (United States)

    Sya Shanida, Sya; Hanik Lestari, Tiffany; Partasasmita, Ruhyat


    The total solar eclipse is an interesting phenomenon because the sun is covered by the moon. This phenomenon is like a night deception for animals, humans, and plants. One of the animals is Bekantan (Nasalis larvatus (Wurmb.)). Nasalis larvatus change its activity when this phenomenon occurs. The aims of the present study are (1) daily activity of Nasalis larvatus on total solar eclipse on March 9th, 2016 and (2) the effect of total solar eclipse on its activity in Mangrove Center, Kariangau, East Kalimantan. The adlibitum method was used in this study on Bekantan's adult female. The result shows that the total solar eclipse has considerable effect on the daily activity of Bekantan. During total solar eclipse, the activity of Bekantan significantly stopped. When the total solar eclipse finished, Bekantan started its daily activity, and it was indicated by feeding activity which was led by alfa-male.

  6. Quality-assurance and data-management plan for water-quality activities in the Kansas Water Science Center, 2014 (United States)

    Rasmussen, Teresa J.; Bennett, Trudy J.; Foster, Guy M.; Graham, Jennifer L.; Putnam, James E.


    As the Nation’s largest water, earth, and biological science and civilian mapping information agency, the U.S. Geological Survey is relied on to collect high-quality data, and produce factual and impartial interpretive reports. This quality-assurance and data-management plan provides guidance for water-quality activities conducted by the Kansas Water Science Center. Policies and procedures are documented for activities related to planning, collecting, storing, documenting, tracking, verifying, approving, archiving, and disseminating water-quality data. The policies and procedures described in this plan complement quality-assurance plans for continuous water-quality monitoring, surface-water, and groundwater activities in Kansas.

  7. Idaho Nuclear Technology and Engineering Center Low-Activity Waste Process Technology Program FY-98 Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Herbst, Alan Keith; Mc Cray, John Alan; Rogers, Adam Zachary; Simmons, R. F.; Palethorpe, S. J.


    The Low-Activity Waste Process Technology Program at the Idaho Nuclear Technology and Engineering Center (INTEC) anticipates that large volumes of low-level/low-activity wastes will need to be grouted prior to near-surface disposal. During fiscal year 1998, three grout formulations were studied for low-activity wastes derived from INTEC liquid sodium-bearing waste. Compressive strength and leach results are presented for phosphate bonding cement, acidic grout, and alkaline grout formulations. In an additional study, grout formulations are recommended for stabilization of the INTEC underground storage tank residual heels.

  8. Idaho Nuclear Technology and Engineering Center Low-Activity Waste Process Technology Program, FY-98 Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Herbst, A.K.; Rogers, A.Z.; McCray, J.A.; Simmons, R.F.; Palethorpe, S.J.


    The Low-Activity Waste Process Technology Program at the Idaho Nuclear Technology and Engineering Center (INTEC) anticipates that large volumes of low-level/low-activity wastes will need to be grouted prior to near-surface disposal. During fiscal year 1998, three grout formulations were studied for low-activity wastes derived from INTEC liquid sodium-bearing waste. Compressive strength and leach results are presented for phosphate bonding cement, acidic grout, and alkaline grout formulations. In an additional study, grout formulations are recommended for stabilization of the INTEC underground storage tank residual heels.

  9. The effect of a school-centered multicomponent intervention on daily physical activity and sedentaary behavior in primary school children : The Active Living study

    NARCIS (Netherlands)

    Kann, Dave Van; Kremers, Stef P.J.; Vries, N.K. de; Vries, S.I. (Sanne); Jansen, M.W.J.


    The aim of the current study was to examine the effectiveness of a school-centered multicomponent PA intervention, called ‘Active Living’, on children's daily PA levels. A quasi-experimental design was used including 9 intervention schools and 9 matched control schools located in the Netherlands. T

  10. Implementation of a metrology programme to provide traceability for radionuclides activity measurements in the CNEN Radiopharmaceuticals Producers Centers

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, Erica A.L. de; Braghirolli, Ana M.S.; Tauhata, Luiz; Gomes, Regio S.; Silva, Carlos J., E-mail: [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Delgado, Jose U.; Oliveira, Antonio E.; Iwahara, Akira, E-mail: [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)


    The commercialization and use of radiopharmaceuticals in Brazil are regulated by Agencia Nacional de Vigilancia Sanitaria (ANVISA) which require Good Manufacturing Practices (GMP) certification for Radiopharmaceuticals Producer Centers. Quality Assurance Program should implement the GMP standards to ensure radiopharmaceuticals have requirements quality to proving its efficiency. Several aspects should be controlled within the Quality Assurance Programs, and one of them is the traceability of the Radionuclides Activity Measurement in radiopharmaceuticals doses. The quality assurance of activity measurements is fundamental to maintain both the efficiency of the nuclear medicine procedures and patient and exposed occupationally individuals safety. The radiation doses received by patients, during the nuclear medicine procedures, is estimated according to administered radiopharmaceuticals quantity. Therefore it is very important either the activity measurements performed in radiopharmaceuticals producer centers (RPC) as the measurements performed in nuclear medicine services are traceable to national standards. This paper aims to present an implementation program to provide traceability to radionuclides activity measurements performed in the dose calibrators(well type ionization chambers) used in Radiopharmaceuticals Producer Center placed in different states in Brazil. The proposed program is based on the principles of GM Pand ISO 17025 standards. According to dose calibrator performance, the RPC will be able to provide consistent, safe and effective radioactivity measurement to the nuclear medicine services. (author)


    The Environmental Photographic Interpretation Center (EPIC) has a 30+ year history of providing remote sensing support to EPA Regional and Program Offices. In addition to the its standard Technical Support mission, EPIC has developed a research program related to emerging technol...

  12. Gaze-centered updating of remembered visual space during active whole-body translation

    NARCIS (Netherlands)

    Pelt, S. van; Medendorp, W.P.


    Various cortical and sub-cortical brain structures update the gaze-centered coordinates of remembered stimuli to maintain an accurate representation of visual space across eyes rotations and to produce suitable motor plans. A major challenge for the computations by these structures is updating acros

  13. FGPA Mission Assurance Center (FMAC) Support Activity at the University of New Mexico (United States)


    two primary tools. The first tool, GNU Radio Companion (GRC), allows the user to drag and drop Digital Signal Processing (DSP) blocks to a workspace...Outputs GRC GNU Radio Companion GSFC NASA Goddard Space Flight Center GUI Graphical User Interface HDL Hardware Descriptive Language HWICAP HardWare...6 4.3 Software Defined Radio (SDR

  14. De novo-designed metallopeptides with type 2 copper centers: modulation of reduction potentials and nitrite reductase activities. (United States)

    Yu, Fangting; Penner-Hahn, James E; Pecoraro, Vincent L


    Enzymatic reactions involving redox processes are highly sensitive to the local electrostatic environment. Despite considerable effort, the complex interactions among different influential factors in native proteins impede progress toward complete understanding of the structure-function relationship. Of particular interest is the type 2 copper center Cu(His)3, which may act as an electron transfer center in peptidylglycine α-hydroxylating monooxygenase (PHM) or a catalytic center in copper nitrite reductase (CuNiR). A de novo design strategy is used to probe the effect of modifying charged amino acid residues around, but not directly bound to, a Cu(His)3 center embedded in three-stranded coiled coils (TRI-H)3 [TRI-H = Ac-G WKALEEK LKALEEK LKALEEK HKALEEK G-NH2]. Specifically, the peptide TRI-EH (=TRI-HK22E) alters an important lysine to glutamate just above the copper binding center. With a series of TRI-EH peptides mutated below the metal center, we use a variety of spectroscopies (EPR, UV-vis, XAS) to show a direct impact on the protonation equilibria, copper binding affinities, reduction potentials, and nitrite reductase activities of these copper-peptide complexes. The potentials at a specific pH vary by 100 mV, and the nitrite reductase activities range over a factor of 4 in rates. We also observe that the affinities, potentials, and catalytic activities are strongly influenced by the pH conditions (pH 5.8-7.4). In general, Cu(II) affinities for the peptides are diminished at low pH values. The interplay among these factors can lead to a 200 mV shift in reduction potential across these peptides, which is determined by the pH-dependent affinities of copper in both oxidation states. This study illustrates the strength of de novo protein design in elucidating the influence of ionizable residues on a particular redox system, an important step toward understanding the factors that govern the properties of this metalloenzyme with a goal of eventually improving the

  15. Dioxygen activation at a mononuclear Cu(I) center embedded in the calix[6]arene-tren core. (United States)

    Izzet, Guillaume; Zeitouny, Joceline; Akdas-Killig, Huriye; Frapart, Yves; Ménage, Stéphane; Douziech, Bénédicte; Jabin, Ivan; Le Mest, Yves; Reinaud, Olivia


    The reaction of a cuprous center coordinated to a calix[6]arene-based aza-cryptand with dioxygen has been studied. In this system, Cu(I) is bound to a tren unit that caps the calixarene core at the level of the small rim. As a result, although protected from the reaction medium by the macrocycle, the metal center presents a labile site accessible to small guest ligands. Indeed, in the presence of O2, it reacts in a very fast and irreversible redox process, leading, ultimately, to Cu(II) species. In the coordinating solvent MeCN, a one electron exchange occurs, yielding the corresponding [CalixtrenCu-MeCN](2+) complex with concomitant release of superoxide in the reaction medium. In a noncoordinating solvent such as CH2Cl2, the dioxygen reaction leads to oxygen insertions into the ligand itself. Both reactions are proposed to proceed through the formation of a superoxide-Cu(II) intermediate that is unstable in the Calixtren environment due to second sphere effects. The transiently formed superoxide ligand either undergoes fast substitution for a guest ligand (in MeCN) or intramolecular redox evolutions toward oxygenation of Calixtren. Interestingly, the latter process was shown to occur twice on the same ligand, thus demonstrating a possible catalytic activation of O2 at a single cuprous center. Altogether, this study illustrates the oxidizing power of a [CuO2](+) adduct and substantiates a mechanism by which copper mono-oxygenases such as DbetaH and PHM activate O2 at the Cu(M) center to produce such an intermediate capable of C-H breaking before the electron input provided by the noncoupled Cu(H) center.

  16. Self-regulation effects in QB-active bacterial reaction centers (United States)

    Goushcha, A. O.; Scott, G. W.; Holzwarth, A. R.; Kharkyanen, V. N.


    Dynamic self-organization effects in proteins under non-equilibrium conditions of photoinduced charge separation are discussed. Successive charge transfer turnover events induce cumulative structural rearrangements with long relaxation times. Perturbations by the modified macromolecular structure on the turnover rate result in an autocatalytic feedback mechanism and may lead to formation of new conformational states. Under such conditions, the efficiency of charge separation and transfer may change by several orders of magnitude, stabilizing the charge-separated state and facilitating charge flow through the molecule. Experimental results on bacterial photosynthetic reaction centers indicate that dynamic self-organization effects determine the function of these macromolecules, favoring stabilization of the charge-separated state over the non-functional recombination event. The protein-cofactor system of reaction centers may be described as a molecular machine that functions under non-equilibrium conditions of electron flow to promote a charge-separated state.

  17. The Door--A Center of Alternatives. Report on Current Activities and Recent Achievements. (United States)

    International Center for Integrative Studies, New York, NY.

    The Door is a youth center in New York, New York, that has the capacity to respond to a myriad of adolescent needs and problems. Over the past 15 years it has serviced over 100,000 teenagers, 53.4 percent of whom were Black, 23.1 percent Hispanic, 20 percent White, 3.5 percent Asian and other; they come from all over the New York City area.…

  18. Climate Change Adaptation Activities at the NASA John F. Kennedy Space Center, FL., USA (United States)

    Hall, Carlton; Phillips, Lynne


    In 2010, the Office of Strategic Infrastructure and Earth Sciences established the Climate Adaptation Science Investigators (CASI) program to integrate climate change forecasts and knowledge into sustainable management of infrastructure and operations needed for the NASA mission. NASA operates 10 field centers valued at $32 billion dollars, occupies 191,000 acres and employs 58,000 people. CASI climate change and sea-level rise forecasts focus on the 2050 and 2080 time periods. At the 140,000 acre Kennedy Space Center (KSC) data are used to simulate impacts on infrastructure, operations, and unique natural resources. KSC launch and processing facilities represent a valued national asset located in an area with high biodiversity including 33 species of special management concern. Numerical and advanced Bayesian and Monte Carlo statistical modeling is being conducted using LiDAR digital elevation models coupled with relevant GIS layers to assess potential future conditions. Results are provided to the Environmental Management Branch, Master Planning, Construction of Facilities, Engineering Construction Innovation Committee and our regional partners to support Spaceport development, management, and adaptation planning and design. Potential impacts to natural resources include conversion of 50% of the Center to open water, elevation of the surficial aquifer, alterations of rainfall and evapotranspiration patterns, conversion of salt marsh to mangrove forest, reductions in distribution and extent of upland habitats, overwash of the barrier island dune system, increases in heat stress days, and releases of chemicals from legacy contamination sites. CASI has proven successful in bringing climate change planning to KSC including recognition of the need to increase resiliency and development of a green managed shoreline retreat approach to maintain coastal ecosystem services while maximizing life expectancy of Center launch and payload processing resources.

  19. Idaho Nuclear Technology and Engineering Center Low-Activity Waste Process Technology Program FY-99 Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Herbst, Alan Keith; Mc Cray, John Alan; Kirkham, Robert John; Pao, Jenn Hai; Hinckley, Steve Harold


    The Low-Activity Waste Process Technology Program at the Idaho Nuclear Technology and Engineering Center (INTEC) anticipates that large volumes of low-level/low-activity wastes will need to be grouted prior to near-surface disposal. During fiscal year 1999, grout formulations were studied for transuranic waste derived from INTEC liquid sodium-bearing waste and for projected newly generated low-level liquid waste. Additional studies were completed on radionuclide leaching, microbial degradation, waste neutralization, and a small mockup for grouting the INTEC underground storage tank residual heels.

  20. Idaho Nuclear Technology and Engineering Center Low-Activity Waste Process Technology Program FY-99 Status Report

    Energy Technology Data Exchange (ETDEWEB)

    A. K. Herbst; J. A. McCray; R. J. Kirkham; J. Pao; S. H. Hinckley


    The Low-Activity Waste Process Technology Program at the Idaho Nuclear Technology and Engineering Center (INTEC) anticipates that large volumes of low-level/low-activity wastes will need to be grouted prior to near-surface disposal. During fiscal year 1999, grout formulations were studied for transuranic waste derived from INTEC liquid sodium-bearing waste and for projected newly generated low-level liquid waste. Additional studies were completed on radionuclide leaching, microbial degradation, waste neutralization, and a small mockup for grouting the INTEC underground storage tank residual heels.

  1. Nature of active centers and mechanism of olefin metathesis on applied oxide catalysts of molybdenum, tungsten and rhenium

    Energy Technology Data Exchange (ETDEWEB)

    Kadushin, A.A. (USSR Academy of Sciences); Aliyev, R.K.; Krylov, O.V.; Andreyev, A.A.; Yedreva-Kardzhiyeva, R.M.; Shopov, D.M.


    The authors undertook a systematic study of the effects of the carrier, activation conditions and the reaction itself on the formation and structure of active centers. Spectral characteristics of the systems studied were compared by infrared, ultraviolet, X-ray-electron and electron absorption spectroscopy, and X-ray-phase and chromatographic analyses. Catalytic activity in a metathesis reaction of propylene and butene-1 was tested in a quartz flow reactor at atmospheric pressure in a temperature range of 25-600/sup 0/C, with contact time of 3-50 seconds. The deposited oxide catalysts of the title minerals are discussed in terms of preparing the catalysts, studying their activity, and observing optical spectra. Tungsten ions were found to reduce at higher temperatures than molbydenum ions. Olefin treatment brought reduction of rhenium to lower oxidation levels. The low activities of Re/sub 2/O/sub 7//MgO at low temperatures is related to difficult electron transfer. The studies indicated the presence of a mobile center in the metathesis of olefins for oxide catalysis of all 3 title minerals, which is dependent on the chemical nature of the carrier and its crystalline structure.

  2. Probing the active center of benzaldehyde lyase with substitutions and the pseudosubstrate analogue benzoylphosphonic acid methyl ester. (United States)

    Brandt, Gabriel S; Nemeria, Natalia; Chakraborty, Sumit; McLeish, Michael J; Yep, Alejandra; Kenyon, George L; Petsko, Gregory A; Jordan, Frank; Ringe, Dagmar


    Benzaldehyde lyase (BAL) catalyzes the reversible cleavage of ( R)-benzoin to benzaldehyde utilizing thiamin diphosphate and Mg (2+) as cofactors. The enzyme is important for the chemoenzymatic synthesis of a wide range of compounds via its carboligation reaction mechanism. In addition to its principal functions, BAL can slowly decarboxylate aromatic amino acids such as benzoylformic acid. It is also intriguing mechanistically due to the paucity of acid-base residues at the active center that can participate in proton transfer steps thought to be necessary for these types of reactions. Here methyl benzoylphosphonate, an excellent electrostatic analogue of benzoylformic acid, is used to probe the mechanism of benzaldehyde lyase. The structure of benzaldehyde lyase in its covalent complex with methyl benzoylphosphonate was determined to 2.49 A (Protein Data Bank entry 3D7K ) and represents the first structure of this enzyme with a compound bound in the active site. No large structural reorganization was detected compared to the complex of the enzyme with thiamin diphosphate. The configuration of the predecarboxylation thiamin-bound intermediate was clarified by the structure. Both spectroscopic and X-ray structural studies are consistent with inhibition resulting from the binding of MBP to the thiamin diphosphate in the active centers. We also delineated the role of His29 (the sole potential acid-base catalyst in the active site other than the highly conserved Glu50) and Trp163 in cofactor activation and catalysis by benzaldehyde lyase.

  3. Vertical flows and structures excited by magnetic activity in the Galactic center region

    CERN Document Server

    Kakiuchi, Kensuke; Fukui, Yasuo; Torii, Kazufumi; Machida, Mami; Matsumoto, Ryoji


    The vertical flow structure in the galactic center region remains poorly understood. We analyzed the MHD simulation data by Suzuki et al. (2015) for better understanding. As a result, we found the fast downflows with a speed of ~100 km/s near the foot-points of magnetic loops. These downflows are flowing along a magnetic field line and accelerated by the gravity. The direction of the fast flows is changed by the magnetic loop geometry, as it moves. As a result, not only vertical motions but also azimuthal and radial motions are excited. This feature could be relevant to the observed high velocity dispersion in the position-velocity diagram.

  4. Nuclear Thermal Propulsion (NTP) Development Activities at the NASA Marshall Space Flight Center - 2006 Accomplishments (United States)

    Ballard, Richard O.


    In 2005-06, the Prometheus program funded a number of tasks at the NASA-Marshall Space Flight Center (MSFC) to support development of a Nuclear Thermal Propulsion (NTP) system for future manned exploration missions. These tasks include the following: 1. NTP Design Develop Test & Evaluate (DDT&E) Planning 2. NTP Mission & Systems Analysis / Stage Concepts & Engine Requirements 3. NTP Engine System Trade Space Analysis and Studies 4. NTP Engine Ground Test Facility Assessment 5. Non-Nuclear Environmental Simulator (NTREES) 6. Non-Nuclear Materials Fabrication & Evaluation 7. Multi-Physics TCA Modeling. This presentation is a overview of these tasks and their accomplishments

  5. New insight on the interaction of self-activated and Mn-related emission centers in ZnS (United States)

    Bacherikov, Yu Yu; Vorona, I.; Zhuk, A.; Gilchuk, A. V.; Korsunska, N.; Markevich, I.


    The photoluminescence (PL) and PL excitation (PLE) spectra of undoped and thermally doped with Mn ZnS single crystals are studied. In the PL spectra, the bands caused by Mn-related and self-activated (SA) emission centers were observed. A number of narrow peaks whose intensity enhanced with increasing Mn content were found in the PLE spectra of SA emission. The same peaks were present in the PLE spectra of the Mn-related emission band. Some of these peaks were previously observed in the absorption spectra and attributed to Mn2+ ions. The appearance of Mn-related peaks in the PLE spectra of SA emission is explained by excitation transfer from the Mn2+ ions to SA emission centers. The conditions required for this transfer and possible mechanisms of the process are discussed.


    Directory of Open Access Journals (Sweden)

    Kovaleva K. A.


    Full Text Available The article is devoted to the phase analysis as a tool preprocessor analysis of a multi-purpose center. Consider the time series of the daily number of requests received on the basis of the phase portraits of these time series. These time series have strong properties of cycles and periodicity. Practice has shown that in modern conditions, for example, for the Russian economy with its instability and financial crises, classical economic theory and statistics, built on linear models, turned out to be unproductive. Overview of approaches and economic-mathematical methods preprocessor analysis of evolutionary economic processes and the corresponding time series allows concluding the following: one versatile, satisfying all the requirements, do not possess the shortcomings of the method of analysis and forecasting does not exist. Each approach and each method has its advantages, disadvantages, limits of use. Most of the known methods of forecasting operate detected in the considered time series properties of cycles and periodicity. Thus, the mere presence of a pronounced cyclicity at different levels of the considered hierarchical model of the time series of the number of requests in a multi-purpose center are important indicators of the possibility of constructing an adequate predictive model number of requests in the multi-purpose centre

  7. Integrative Student Learning: An Effective Team Learning Activity in a Learner-Centered Paradigm

    Directory of Open Access Journals (Sweden)

    Reza Karimi, RPh, PhD


    Full Text Available Purpose: An Integrative Student Learning (ISL activity was developed with the intent to enhance the dynamic of student teamwork and enhance student learning by fostering critical-thinking skills, self-directed learning skills, and active learning. Case Study: The ISL activity consists of three portions: teambuilding, teamwork, and a facilitator driven “closing the loop” feedback discussion. For teambuilding, a set of clue sheets or manufacturer‘s drug containers were distributed among student pairs who applied their pharmaceutical knowledge to identify two more student pairs with similar clues or drugs, thus building a team of six. For teamwork, each team completed online exams, composed of integrated pharmaceutical science questions with clinical correlates, using only selected online library resources. For the feedback discussion, facilitators evaluated student impressions, opened a discussion about the ISL activity, and provided feedback to teams’ impressions and questions. This study describes three different ISL activities developed and implemented over three days with first year pharmacy students. Facilitators’ interactions with students and three surveys indicated a majority of students preferred ISL over traditional team activities and over 90% agreed ISL activities promoted active learning, critical-thinking, self-directed learning, teamwork, and student confidence in online library searches. Conclusions: The ISL activity has proven to be an effective learning activity that promotes teamwork and integration of didactic pharmaceutical sciences to enhance student learning of didactic materials and confidence in searching online library resources. It was found that all of this can be accomplished in a short amount of class time with a very reasonable amount of preparation.

  8. Active Living: development and quasi-experimental evaluation of a school-centered physical activity intervention for primary school children

    NARCIS (Netherlands)

    Kann, D.H.H. van; Jansen, M.W.J.; Vries, S.I. de; Vries, N.K. de; Kremers, S.P.J.


    Background The worldwide increase in the rates of childhood overweight and physical inactivity requires successful prevention and intervention programs for children. The aim of the Active Living project is to increase physical activity and decrease sedentary behavior of Dutch primary school children

  9. Accelerating Energy Efficiency in Indian Data Centers. Final Report for Phase I Activities

    Energy Technology Data Exchange (ETDEWEB)

    Ganguly, Suprotim [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Raje, Sanyukta [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Kumar, Satish [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sartor, Dale [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Greenberg, Steve [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)


    This report documents Phase 1 of the “Accelerating Energy Efficiency in Indian Data Centers” initiative to support the development of an energy efficiency policy framework for Indian data centers. The initiative is being led by the Confederation of Indian Industry (CII), in collaboration with Lawrence Berkeley National Laboratory (LBNL)-U.S. Department of Energy’s Office of Energy Efficiency and Renewable Energy, and under the guidance of Bureau of Energy Efficiency (BEE). It is also part of the larger Power and Energy Efficiency Working Group of the US-India Bilateral Energy Dialogue. The initiative consists of two phases: Phase 1 (November 2014 – September 2015) and Phase 2 (October 2015 – September 2016).


    Energy Technology Data Exchange (ETDEWEB)

    Robert C. O' Brien


    Nuclear power has been considered for space applications since the 1960s. Between 1955 and 1972 the US built and tested over twenty nuclear reactors/ rocket-engines in the Rover/NERVA programs. However, changes in environmental laws may make the redevelopment of the nuclear rocket more difficult. Recent advances in fuel fabrication and testing options indicate that a nuclear rocket with a fuel form significantly different from NERVA may be needed to ensure public support. The Center for Space Nuclear Research (CSNR) is pursuing development of tungsten based fuels for use in a NTR, for a surface power reactor, and to encapsulate radioisotope power sources. The CSNR Summer Fellows program has investigated the feasibility of several missions enabled by the NTR. The potential mission benefits of a nuclear rocket, historical achievements of the previous programs, and recent investigations into alternatives in design and materials for future systems will be discussed.

  11. Designing a knowledge management system for distributed activities: a human centered approach. (United States)

    Rinkus, Susan; Johnson-Throop, Kathy A; Zhang, Jiajie


    In this study we use the principles of distributed cognition and the methodology of human-centered distributed information design to analyze a complex distributed human-computer system, identify its problems, and generate design requirements and implementation specifications of a replacement prototype for effective organizational memory and knowledge management. We argue that a distributed human-computer information system has unique properties, structures and processes that are best described in the language of distributed cognition. Distributed cognition provides researchers a richer theoretical understanding of human-computer interactions and enables re-searchers to capture the phenomenon that emerges in social interactions as well as the interactions between people and structures in their environment.

  12. Activities of the NASA/Marshall Space Flight Center pump stage technology team (United States)

    Garcia, R.; Mcconnaughey, P.; Eastland, A.


    In order to advance rocket propulsion technology, the Consortium for Computational Fluid Dynamics (CFD) Application in Propulsion Technology has been formed at Marshall Space Flight Center (MSFC). The Consortium consists of three Teams: the turbine stage team, the pump stage team (PST), and the combustion devices team. The PST has formulated and is implementing a plan for pump technology development whose end product will be validated CFD codes suitable for application to pump components, test data suitable for validating CFD codes, and advanced pump components optimized using CFD codes. The PST's work during the fall of 1991 and the winter and spring of 1992 is discussed in this paper. This work is highlighted by CFD analyses of an advanced impeller design and collection of laser two-focus velocimeter data for the Space Shuttle Main Engine High Pressure Fuel Pump impeller.

  13. Extravehicular Activity Testing in Analog Environments: Evaluating the Effects of Center of Gravity and Environment on Human Performance (United States)

    Chappell, Steve P.; Gernhardt, Michael L.


    Center of gravity (CG) is likely to be an important variable in astronaut performance during partial gravity extravehicular activity (EVA). The Apollo Lunar EVA experience revealed challenges with suit stability and control. The EVA Physiology, Systems and Performance Project (EPSP) in conjunction with the Constellation EVA Systems Project Office have developed plans to systematically understand the role of suit weight, CG and suit pressure on astronaut performance in partial gravity environments. This presentation based upon CG studies seeks to understand the impact of varied CG on human performance in lunar gravity.

  14. Direct observation of the active center for methane dehydroaromatization using an ultrahigh field 95Mo NMR spectroscopy. (United States)

    Zheng, Heng; Ma, Ding; Bao, Xinhe; Hu, Jian Zhi; Kwak, Ja Hun; Wang, Yong; Peden, Charles H F


    The use of an ultrahigh magnetic field spectrometer and 95Mo isotope enrichment facilitate the direct observation of the local structure of Mo species on Mo/zeolite catalysts by 95Mo NMR. Top trace: The experimental 95Mo NMR spectrum of 6Mo/HZSM-5. Bottom traces: The simulated overall spectrum (orange), the spectral component corresponding to MoO3 (purple), and the component corresponding to the exchanged Mo species (green). The exchanged Mo species proved to be the active center for the methane dehydroaromatization (MDA) reaction.

  15. Idaho Nuclear Technology and Engineering Center Low-Activity Waste Process Technology Program FY-2000 Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Herbst, Alan Keith; Mc Cray, John Alan; Kirkham, Robert John; Pao, Jenn Hai; Argyle, Mark Don; Lauerhass, Lance; Bendixsen, Carl Lee; Hinckley, Steve Harold


    The Low-Activity Waste Process Technology Program anticipated that grouting will be used for disposal of low-level and transuranic wastes generated at the Idaho Nuclear Technology Engineering Center (INTEC). During fiscal year 2000, grout formulations were studied for transuranic waste derived from INTEC liquid sodium-bearing waste and for projected newly generated low-level liquid waste. Additional studies were completed using silica gel and other absorbents to solidify sodium-bearing wastes. A feasibility study and conceptual design were completed for the construction of a grout pilot plant for simulated wastes and demonstration facility for actual wastes.

  16. Idaho Nuclear Technology and Engineering Center Low-Activity Waste Process Technology Program FY-2000 Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Herbst, A.K.; McCray, J.A.; Kirkham, R.J.; Pao, J.; Argyle, M.D.; Lauerhass, L.; Bendixsen, C.L.; Hinckley, S.H.


    The Low-Activity Waste Process Technology Program anticipated that grouting will be used for disposal of low-level and transuranic wastes generated at the Idaho Nuclear Technology Engineering Center (INTEC). During fiscal year 2000, grout formulations were studied for transuranic waste derived from INTEC liquid sodium-bearing waste and for projected newly generated low-level liquid waste. Additional studies were completed using silica gel and other absorbents to solidify sodium-bearing wastes. A feasibility study and conceptual design were completed for the construction of a grout pilot plant for simulated wastes and demonstration facility for actual wastes.

  17. Validation of Using Fitness Center Attendance Electronic Records to Assess the Frequency of Moderate/Vigorous Leisure-Time Physical Activity among Adults (United States)

    Amireault, Steve; Godin, Gaston


    The purpose of this study was to provide three construct validity evidence for using fitness center attendance electronic records to objectively assess the frequency of leisure-time physical activity among adults. One hundred members of a fitness center (45 women and 55 men; aged 18 to 64 years) completed a self-report leisure-time physical…

  18. A dicopper complex with distant metal centers. Structure, magnetic properties, electrochemistry and catecholase activity. (United States)

    Gasque, Laura; Ugalde-Saldívar, Víctor Manuel; Membrillo, Ingrid; Olguín, Juan; Mijangos, Edgar; Bernès, Sylvain; González, Ignacio


    The crystal structure and magnetic properties of a dinuclear copper(II) complex of the ligand [2,8-dimethyl-5,11-di-(dimethylethyleneamine) 1,4,5,6,7,10,11,12-octahydroimidazo [4,5-h] imidazo [4,5-c] [1,6]diazecine] dimeim have been investigated. Also, its catecholase activity has been explored in different solvent mixtures: MeCN/H2O and OH/H2O, each at several pH values. In CH3OH/H2O, where the activity was superior, the optimal pH value for the catalytic activity was found to be lower than in CH3CN/H2O. The study of the complex's electrochemical behavior (cyclic voltammetry) which was also investigated in these various media, revealed that although an increase in pH in both solvent mixtures results in an increase both in Me oxidizing power (E(1/2)) and reversibility (ipa/ipc) the change of solvent system seems to be a more influencing factor. The superior catalytic activity found in MeOH/H2O pH=8.0, is associated with a significantly more reversible behavior displayed in this medium. Potentiometric determination of the overall formation constant and three successive pKas for the complex, suggest the formation of stable hydroxo complexes which could be the catalytically active species.

  19. A New Perspective of the Radio Bright Zone at The Galactic Center: Feedback from Nuclear Activities

    CERN Document Server

    Zhao, Jun-Hui; Goss, W M


    New observations of Sgr A have been carried out with the VLA using the broadband (2 GHz) continuum mode at 5.5 GHz, covering the central 30 pc region of the RBZ at the Galactic center. Using the MS-MFS algorithms in CASA, we have imaged Sgr A with a resolution of 1", achieving an rms 8 $\\mu$Jy/beam, and a dynamic range 100,000:1.The radio image is compared with X-ray, CN emission-line and Paschen-$\\alpha$ images obtained using Chandra, SMA and HST/NICMOS, respectively. We discuss several prominent radio features. The "Sgr A West Wings" extend 5 pc from the NW and SE tips of the ionized "Mini-spiral" in Sgr A West to positions located 2.9 and 2.4 arc min to the NW and SE of Sgr A*, respectively. The NW wing, along with several other prominent features, including the "NW Streamers", form an elongated radio lobe (NW lobe), oriented nearly perpendicular to the Galactic plane. This radio lobe, with a size of 14.4 pc x 7.3 pc, has a known X-ray counterpart. A row of three thermally emitting rings is observed in the...

  20. Diffuse gamma-ray emission from the Galactic center and implications of its past activities

    CERN Document Server

    Fujita, Yutaka; Murase, Kohta


    It has been indicated that low-luminosity active galactic nuclei (LLAGNs) are accelerating high-energy cosmic-ray (CR) protons in their radiatively inefficient accretion flows (RIAFs). If this is the case, Sagittarius A* (Sgr A*) should also be generating CR protons, because Sgr A* is a LLAGN. Based on this scenario, we calculate a production rate of CR protons in Sgr A* and their diffusion in the central molecular zone (CMZ) around Sgr A*. The CR protons diffusing in the CMZ create gamma-rays through pp interaction. We show that the gamma-ray luminosity and spectrum are consistent with observations if Sgr A* was active in the past.

  1. A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers (United States)

    The patterning and growth of the embryonic vertebrate limb is dependent on Sonic hedgehog (Shh), a morphogen that regulates the activity of Gli transcription factors. However, "Shh" expression is not observed during the first 12 hours of limb development. During this phase, the limb bud is prepatter...

  2. Thermal Technology Development Activities at the Goddard Space Flight Center: 2001 (United States)

    Butler, Dan; Powers, Edward I. (Technical Monitor)


    Activities include the development of two phase systems which are composed of 1) heat pipes and variable conductance heat pipes, 2)capillary pumped loops, 3) loop heat pipes, 4) vapor compression systems (heat pumps), 5) phase change materials. Also in the development phase are variable emittance surfaces, advanced coatings, high conductivity materials, and electrohydrodynamic (EHD) thermal control systems.

  3. Direct Observation of the Active Center for Methane Dehydroaromatization Using an Ultrahigh Field 95Mo NMR Spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, Heng; Ma, Ding; Bao, Xinhe; Hu, Jian Zhi; Kwak, Ja Hun; Wang, Yong; Peden, Charles HF


    Direct conversion of methane to value-added chemicals remains a challenge from both scientific and industrial points of view. In 1993, Wang et al. reported that methane can be transformed into aromatics on Mo/HZSM-5 catalysts under non-oxidative condition.1 Although remarkable progress has been made in the studies of the methane dehydroaromatization (MDA) reaction since that time, the reaction mechanism is still being debated,2 mainly due to the lack of understanding of the active center on Mo/HZSM-5 catalysts.3 It has been hypothesized that molybdenum may migrate into zeolitic channels and anchor on Brönsted acid sites during the synthesis. However, it is unclear whether the active molybdenum species are small crystallites or isolated exchanged species.

  4. Education of natural science in the work of the Municipal Center for Extracurricular Activities (United States)

    Jokin, I.


    In the description of my work I presented my own experience in the organizing and carrying out of extracurricular activities with the students, the used modes and methods of work, the obtained results and some good practices in the field of natural sciences. Organizing and carrying out of scientific festivals, participation in joint projects together with scientific organizations. Key words: European dimension, interactive methods, key competences, natural sciences, extracurricular activities. We are witnesses of a fundamental change in the pedagogical culture and practice in our schools to establish the parameters of the quality of training. The good scientific culture is an important part of the students' education. Unfortunately, at the present time the scientific and technological culture is on a low level. One of the contemporary problems and realities of the education in natural science school subjects, as a whole and in particular in the secondary education, is the decreased interest for the training in them and in particular in physics, as well as synchronization of the interrelations: school environment - society. In many countries there is a drop in the orientation of the students towards the science and technology - the problem of Science and Technology (S&T). The training of the young people often creates some problems. The teachers meet with the problem of insufficient motivation of the learners for study and difficulties that they encounter in the process of training. The students find it difficult to apply the mastered knowledge to an applied context. The knowledge is rather academic and rather remote from the context, in which the children live and communicate, which makes it nonfunctional. At present there are not enough extracurricular activities that should meet these necessities of the Bulgarian school. The reasons are various, but they mainly consist in the lack of a material base, an exchange of experience and good practices and motivation

  5. Investigating the effect of an empowerment program on physical activity of the elderly in Rezaeian Health Center, Iran, in 2014 (United States)

    Manavi, Narges; Abedi, Heidarali


    Background: Reaching geriatric period is one of the greatest successes in human Beings. The older adults are predisposed to risk of many diseases and disabilities, and physical activity is one of the most efficient methods to prevent geriatric period disorders. Therefore, the present study aimed define the effect of an empowerment program on physical activity of the elderly residing in Shahid Rezaian health care center in 2014. Materials and Methods: This quasi-experimental study was conducted on 70 older adults, age 65 years and over, selected through convenient sampling and assigned to groups of study and control. Study group was divided into 5 seven-member subgroups and a one-hour session of physical exercises was administrated for them once a week for eight sequential weeks. All subjects evaluated before and after intervention by International Physical Activity Questionnaire. Subjects’ physical activity was scored, based on the personal activity protocol,and the results were compared. Significance level was considered as P<0.05. Results: Frequency distributions of the female subjects were 29 (82%) and 28 (80%) in study and control groups respectively. Mean (SD) scores of physical activity were 347.8 (174.1) and 321.7 (119.2) before intervention, and 641.3 (240.6) and 331.3 (101.5) after intervention in study and control groups respectively. Independent t-test showed a significant increase in physical activity score in study group, compared to control (t=4.06, P<0.001). Conclusions: The level of physical activity can be improved in the elderly through application of an empowerment program so as to take steps toward solving their immobility related problems and promoting their health through application of an empowerment program at this period of their life. PMID:27563315

  6. Activities and Plan of the Center for Geophysics (Beijing) from WDC to WDS


    Peng, Fenglin; Ma, Maining; Peng, Le; Zhang, Jian; Chen, Gengxiong; Li, Yufang; Sun, Bo; Zhang, Yunfei


    In this report we introduce the development of the WDC for Geophysics, Beijing included our activities in the electronic Geophysical Year (eGY) and in the transition period from WDC to WDS. We also present our future plans. We have engaged in the development of geophysical informatics and related data science. We began the data visualization of geomagnetic fields in the GIS system. Our database has been expanded from geomagnetic data to the data of solid geophysics, including geothermal data,...

  7. Photometric Monitoring of Active Galactic Nuclei in the Center for Automated Space Science: Preliminary Results (United States)

    Culler, Ryan; Deckard, Monica; Guilaran, Fonsie; Watson, Casey; Carini, Michael; Gelderman, Richard; Neely, William


    In this paper, we will present preliminary results of our program to photometrically monitor a set of Active Galactic Nuclei (AGN) known as Blazars. Using CCDs as N-star photometers and a technique known as aperture photometry, we can achieve close to 0.02 magnitude precision with small to midsize telescopes. Blazars are highly luminous and highly variable; studying these variations provides insight into the central engines producing the high luminosities. we report on our reduction and analysis of CCD data obtained at one of our collaborating institutions, the NF Observatory at Western New Mexico University. CCD data obtained at the Western Kentucky University 24 inch telescope will also be discussed.

  8. Activation volume measurement for C[bond]H activation. Evidence for associative benzene substitution at a platinum(II) center. (United States)

    Procelewska, Joanna; Zahl, Achim; van Eldik, Rudi; Zhong, H Annita; Labinger, Jay A; Bercaw, John E


    The reaction of the platinum(II) methyl cation [(N-N)Pt(CH(3))(solv)](+) (N-N = ArN[double bond]C(Me)C(Me)[double bond]NAr, Ar = 2,6-(CH(3))(2)C(6)H(3), solv = H(2)O (1a) or TFE = CF(3)CH(2)OH (1b)) with benzene in TFE/H(2)O solutions cleanly affords the platinum(II) phenyl cation [(N-N)Pt(C(6)H(5))(solv)](+) (2). High-pressure kinetic studies were performed to resolve the mechanism for the entrance of benzene into the coordination sphere. The pressure dependence of the overall second-order rate constant for the reaction resulted in Delta V(++) = -(14.3 +/- 0.6) cm(3) mol(-1). Since the overall second order rate constant k = K(eq)k(2), Delta V(++) = Delta V degrees (K(eq)) + Delta V(++)(k(2)). The thermodynamic parameters for the equilibrium constant between 1a and 1b, K(eq) = [1b][H(2)O]/[1a][TFE] = 8.4 x 10(-4) at 25 degrees C, were found to be Delta H degrees = 13.6 +/- 0.5 kJ mol(-1), Delta S degrees = -10.4 +/- 1.4 J K(-1) mol(-1), and Delta V degrees = -4.8 +/- 0.7 cm(3) mol(-1). Thus DeltaV(++)(k(2)) for the activation of benzene by the TFE solvento complex equals -9.5 +/- 1.3 cm(3) mol(-1). This significantly negative activation volume, along with the negative activation entropy for the coordination of benzene, clearly supports the operation of an associative mechanism.


    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Jun-Hui [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Morris, Mark R. [Department of Physics and Astronomy, University of California Los Angeles, Los Angeles, CA 90095 (United States); Goss, W. M., E-mail: [NRAO, P.O. Box O, Socorro, NM 87801 (United States)


    New observations of Sgr A have been carried out with the Jansky VLA in the B and C arrays using the broadband (2 GHz) continuum mode at 5.5 GHz. The field of view covers the central 13′ (30 pc) region of the radio-bright zone at the Galactic center. Using the multi-scale and multi-frequency-synthesis (MS-MFS) algorithms in CASA, we have imaged Sgr A with a resolution of 1″, achieving an rms noise of 8 μJy beam{sup −1}, and a dynamic range of 100,000:1. Both previously known and newly identified radio features in this region are revealed, including numerous filamentary sources. The radio continuum image is compared with Chandra X-ray images, with a CN emission-line image obtained with the Submillimeter Array and with detailed Paschen-α images obtained with Hubble Space Telescope/NICMOS. We discuss several prominent features in the radio image. The “Sgr A west Wings” extend 2′ (5 pc) from the NW and SE tips of the Sgr A west H ii region (the “Mini-spiral”) to positions located 2.9 and 2.4 arcmin to the northwest and southeast of Sgr A*, respectively. The NW wing, along with several other prominent features, including the previously identified “NW Streamers,” form an elongated radio lobe (NW lobe), oriented nearly perpendicular to the Galactic plane. This radio lobe, with a size of 6.′3 × 3.′2 (14.4 pc × 7.3 pc), has a known X-ray counterpart. In the outer region of the NW lobe, a row of three thermally emitting rings is observed. A field containing numerous amorphous radio blobs extends for a distance of ∼2 arcmin beyond the tip of the SE wing; these newly recognized features coincide with the SE X-ray lobe. Most of the amorphous radio blobs in the NW and SE lobes have Paschen-α counterparts. We propose that they have been produced by shock interaction of ambient gas concentrations with a collimated nuclear wind or an outflow that originated from within the circumnuclear disk (CND). We also discuss the possibility that the ionized

  10. A New Perspective of the Radio Bright Zone at The Galactic Center: Feedback from Nuclear Activities (United States)

    Zhao, Jun-Hui; Morris, Mark R.; Goss, W. M.


    New observations of Sgr A have been carried out with the Jansky VLA in the B and C arrays using the broadband (2 GHz) continuum mode at 5.5 GHz. The field of view covers the central 13‧ (30 pc) region of the radio-bright zone at the Galactic center. Using the multi-scale and multi-frequency-synthesis (MS-MFS) algorithms in CASA, we have imaged Sgr A with a resolution of 1″, achieving an rms noise of 8 μJy beam-1, and a dynamic range of 100,000:1. Both previously known and newly identified radio features in this region are revealed, including numerous filamentary sources. The radio continuum image is compared with Chandra X-ray images, with a CN emission-line image obtained with the Submillimeter Array and with detailed Paschen-α images obtained with Hubble Space Telescope/NICMOS. We discuss several prominent features in the radio image. The “Sgr A west Wings” extend 2‧ (5 pc) from the NW and SE tips of the Sgr A west H ii region (the “Mini-spiral”) to positions located 2.9 and 2.4 arcmin to the northwest and southeast of Sgr A*, respectively. The NW wing, along with several other prominent features, including the previously identified “NW Streamers,” form an elongated radio lobe (NW lobe), oriented nearly perpendicular to the Galactic plane. This radio lobe, with a size of 6.‧3 × 3.‧2 (14.4 pc × 7.3 pc), has a known X-ray counterpart. In the outer region of the NW lobe, a row of three thermally emitting rings is observed. A field containing numerous amorphous radio blobs extends for a distance of ˜2 arcmin beyond the tip of the SE wing; these newly recognized features coincide with the SE X-ray lobe. Most of the amorphous radio blobs in the NW and SE lobes have Paschen-α counterparts. We propose that they have been produced by shock interaction of ambient gas concentrations with a collimated nuclear wind or an outflow that originated from within the circumnuclear disk (CND). We also discuss the possibility that the ionized wind or

  11. BKG Data Center (United States)

    Thorandt, Volkmar; Wojdziak, Reiner


    This report summarizes the activities and background information of the IVS Data Center for the year 2012. Included is information about functions, structure, technical equipment, and staff members of the BKG Data Center.

  12. Activities and Plan of the Center for Geophysics (Beijing from WDC to WDS

    Directory of Open Access Journals (Sweden)

    Fenglin Peng


    Full Text Available In this report we introduce the development of the WDC for Geophysics, Beijing included our activities in the electronic Geophysical Year (eGY and in the transition period from WDC to WDS. We also present our future plans. We have engaged in the development of geophysical informatics and related data science. We began the data visualization of geomagnetic fields in the GIS system. Our database has been expanded from geomagnetic data to the data of solid geophysics, including geothermal data, gravity data, and the records of aurora sightings in ancient China. We also joined the study of the history of the development of geophysics in China organized by the Chinese Geophysical Society (CGS.

  13. Identification of histidine residue in active center of Escherichia coli RNA-polymerase

    Energy Technology Data Exchange (ETDEWEB)

    Grachev, M.A.; Mustaev, A.A.; Kolocheva, T.I.


    Affinity labeling with beta-imidazole GDP, DNA phage T7 promotor, and alpha-/sup 32/P-UTP were used to mark the histidine residue in the active site of E. coli RNA-polymerase. Mild acid treatment led to complete demodification, while kinetic demodification with dodecylsulfate corresponded to that obtained with model modified histidine, and differed sharply from kinetic hydrolysis of a phosphamide bond. The histidine residue was identified by degrading the labeled peptide with cyanogen bromide and measuring the length of the radioactive peptides obtained by SDS disc-electrophoresis. This indicated that the labeled histidine was between methionines 1107 and 1119. The only histidine in this location is number 1116. This method for partial protein sequencing has general applicability. 10 references, 3 figures.

  14. Rotary-Wing Relevant Compressor Aero Research and Technology Development Activities at Glenn Research Center (United States)

    Welch, Gerard E.; Hathaway, Michael D.; Skoch, Gary J.; Snyder, Christopher A.


    Technical challenges of compressors for future rotorcraft engines are driven by engine-level and component-level requirements. Cycle analyses are used to highlight the engine-level challenges for 3000, 7500, and 12000 SHP-class engines, which include retention of performance and stability margin at low corrected flows, and matching compressor type, axial-flow or centrifugal, to the low corrected flows and high temperatures in the aft stages. At the component level: power-to-weight and efficiency requirements impel designs with lower inherent aerodynamic stability margin; and, optimum engine overall pressure ratios lead to small blade heights and the associated challenges of scale, particularly increased clearance-to-span ratios. The technical challenges associated with the aerodynamics of low corrected flows and stability management impel the compressor aero research and development efforts reviewed herein. These activities include development of simple models for clearance sensitivities to improve cycle calculations, full-annulus, unsteady Navier-Stokes simulations used to elucidate stall, its inception, and the physics of stall control by discrete tip-injection, development of an actuator-duct-based model for rapid simulation of nonaxisymmetric flow fields (e.g., due inlet circumferential distortion), advanced centrifugal compressor stage development and experimentation, and application of stall control in a T700 engine.

  15. Hypothetical biotechnology companies: A role-playing student centered activity for undergraduate science students. (United States)

    Chuck, Jo-Anne


    Science students leaving undergraduate programs are entering the biotechnology industry where they are presented with issues which require integration of science content. Students find this difficult as through-out their studies, most content is limited to a single subdiscipline (e.g., biochemistry, immunology). In addition, students need knowledge of the ethical, economic, and legal frame work in which the industry operates. This article presents an approach to deliver these outcomes in a collaborative and active learning modality which promotes deep learning. In the model, groups of final year undergraduate students form hypothetical biotechnology companies and identify real issues of interest to industry, make integrative team decisions, use professional level technology, and develop appropriate communication skills. The final successful teaching paradigm was based on self reflection, observation, and student feedback to ensure appropriate attainment of content, group work skills and increased confidence in professional decision-making. It is these outcomes which will facilitate life long learning skills, a major outcome applicable for all tertiary education.

  16. Modeling crustal deformation near active faults and volcanic centers: a catalog of deformation models and modeling approaches (United States)

    Battaglia, Maurizio; ,; Peter, F.; Murray, Jessica R.


    This manual provides the physical and mathematical concepts for selected models used to interpret deformation measurements near active faults and volcanic centers. The emphasis is on analytical models of deformation that can be compared with data from the Global Positioning System (GPS) receivers, Interferometric synthetic aperture radar (InSAR), leveling surveys, tiltmeters and strainmeters. Source models include pressurized spherical, ellipsoidal, and horizontal penny-shaped geometries in an elastic, homogeneous, flat half-space. Vertical dikes and faults are described following the mathematical notation for rectangular dislocations in an elastic, homogeneous, flat half-space. All the analytical expressions were verified against numerical models developed by use of COMSOL Multyphics, a Finite Element Analysis software ( In this way, typographical errors present were identified and corrected. Matlab scripts are also provided to facilitate the application of these models.

  17. Structural Changes of the Active Center during the Photoactivation of Xenopus (6-4) Photolyase. (United States)

    Yamada, Daichi; Yamamoto, Junpei; Zhang, Yu; Iwata, Tatsuya; Hitomi, Kenichi; Getzoff, Elizabeth D; Iwai, Shigenori; Kandori, Hideki


    Photolyases (PHRs) repair the UV-induced photoproducts, cyclobutane pyrimidine dimer (CPD) or pyrimidine-pyrimidone (6-4) photoproduct [(6-4) PP], restoring normal bases to maintain genetic integrity. CPD and (6-4) PP are repaired by substrate-specific PHRs, CPD PHR and (6-4) PHR, respectively. Flavin adenine dinucleotide (FAD) is the chromophore of both PHRs, and the resting oxidized form (FAD(ox)), at least under in vitro purified conditions, is first photoconverted to the neutral semiquinoid radical (FADH(•)) form, followed by photoconversion into the enzymatically active fully reduced (FADH(-)) form. Previously, we reported light-induced difference Fourier transform infrared (FTIR) spectra corresponding to the photoactivation process of Xenopus (6-4) PHR. Spectral differences between the absence and presence of (6-4) PP were observed in the photoactivation process. To identify the FTIR signals where these differences appeared, we compared the FTIR spectra of photoactivation (i) in the presence and absence of (6-4) PP, (ii) of (13)C labeling, (15)N labeling, and [(14)N]His/(15)N labeling, and (iii) of H354A and H358A mutants. We successfully assigned the vibrational bands for (6-4) PP, the α-helix and neutral His residue(s). In particular, we assigned three bands to the C ═ O groups of (6-4) PP in the three different redox states of FAD. Furthermore, the changed hydrogen bonding environments of C ═ O groups of (6-4) PP suggested restructuring of the binding pocket of the DNA lesion in the process of photoactivation.

  18. Study on the distribution of active centers in novel low Ti-loading MgCl2-supported Ziegler-Natta catalyst

    Institute of Scientific and Technical Information of China (English)

    王剑峰; 王立; 赵振荣; 王文钦; 陈涛


    Novel MgCl2-supported Ziegler-Natta (Z-N) catalysts prepared using a new one-pot ball milling method can effectively control the amounts of Ti-loading in the catalysts. Complex GPC data on polypropylene synthesized by these novel catalysts were analyzed using the method of fitting the molecular weight distribution (MWD) curves with a multiple Flory-Schulz function. It was found that multiple active centers exist in these novel catalysts. Detailed study of the effects of the Ti-loadings in the catalysts on the distribution of the active centers showed that the Ti-loadings in the novel MgCl2-supported Z-N catalysts might affect the proportion of each type of active centers; and might be the main factor responsible for the effect of the Ti-loadings on the microstructure, the molecular weight and molecular weight distribution width of the resultant polymer, the catalytic activity and polymerization kinetics.

  19. Sports Facilities, Shopping Centers or Homes: What Locations are Important for Adults' Physical Activity? A Cross-Sectional Study. (United States)

    Jansen, Marijke; Ettema, Dick; Pierik, Frank; Dijst, Martin


    Physical activity (PA) is influenced by the built environment. However, little is known about the types of built environment where adults spend their time, and at what levels of PA they engage in those environments. Understanding the effect of the built environment on PA requires insight into PA behavior at different types of locations (e.g., home, work, shopping centers, and sports facilities). Therefore, this study describes where adults aged 45-65 years were active with moderate-to-vigorous intensity (MVPA), and examines associations of socio-demographic factors and neighborhood with MVPA at these locations. Participants' (N = 308) PA was measured for seven days using accelerometers and GPS-devices. Adults spent most minutes of MVPA at home and work. Highest MVPA-ratios of total time spent at a location were achieved in sports facilities and during transport. Neighborhood characteristics and socio-demographic factors such as work status, health status and household structure, had significant effects on MVPA at various locations and on total MVPA. Understanding PA behavior at various locations may provide insights that allow professionals in different domains (e.g., health, landscaping, urban planning) to develop strategies to stimulate PA.

  20. Excellence in Physics Education Award: SCALE-UP, Student Centered Active Learning Environment with Upside-down Pedagogies (United States)

    Beichner, Robert


    The Student-Centered Active Learning Environment with Upside-down Pedagogies (SCALE-UP) Project combines curricula and a specially-designed instructional space to enhance learning. SCALE-UP students practice communication and teamwork skills while performing activities that enhance their conceptual understanding and problem solving skills. This can be done with small or large classes and has been implemented at more than 250 institutions. Educational research indicates that students should collaborate on interesting tasks and be deeply involved with the material they are studying. SCALE-UP classtime is spent primarily on ``tangibles'' and ``ponderables''--hands-on measurements/observations and interesting questions. There are also computer simulations (called ``visibles'') and hypothesis-driven labs. Students sit at tables designed to facilitate group interactions. Instructors circulate and engage in Socratic dialogues. The setting looks like a banquet hall, with lively interactions nearly all the time. Impressive learning gains have been measured at institutions across the US and internationally. This talk describes today's students, how lecturing got started, what happens in a SCALE-UP classroom, and how the approach has spread. The SCALE-UP project has greatly benefitted from numerous Grants made by NSF and FIPSE to NCSU and other institutions.

  1. JPSS Proving Ground Activities with NASA's Short-term Prediction Research and Transition (SPoRT) Center (United States)

    Schultz, L. A.; Smith, M. R.; Fuell, K.; Stano, G. T.; LeRoy, A.; Berndt, E.


    Instruments aboard the Joint Polar Satellite System (JPSS) series of satellites will provide imagery and other data sets relevant to operational weather forecasts. To prepare current and future weather forecasters in application of these data sets, Proving Ground activities have been established that demonstrate future JPSS capabilities through use of similar sensors aboard NASA's Terra and Aqua satellites, and the S-NPP mission. As part of these efforts, NASA's Short-term Prediction Research and Transition (SPoRT) Center in Huntsville, Alabama partners with near real-time providers of S-NPP products (e.g., NASA, UW/CIMSS, UAF/GINA, etc.) to demonstrate future capabilities of JPSS. This includes training materials and product distribution of multi-spectral false color composites of the visible, near-infrared, and infrared bands of MODIS and VIIRS. These are designed to highlight phenomena of interest to help forecasters digest the multispectral data provided by the VIIRS sensor. In addition, forecasters have been trained on the use of the VIIRS day-night band, which provides imagery of moonlit clouds, surface, and lights emitted by human activities. Hyperspectral information from the S-NPP/CrIS instrument provides thermodynamic profiles that aid in the detection of extremely cold air aloft, helping to map specific aviation hazards at high latitudes. Hyperspectral data also support the estimation of ozone concentration, which can highlight the presence of much drier stratospheric air, and map its interaction with mid-latitude or tropical cyclones to improve predictions of their strengthening or decay. Proving Ground activities are reviewed, including training materials and methods that have been provided to forecasters, and forecaster feedback on these products that has been acquired through formal, detailed assessment of their applicability to a given forecast threat or task. Future opportunities for collaborations around the delivery of training are proposed

  2. Environmental systems and management activities on the Kennedy Space Center, Merritt Island, Florida: results of a modeling workshop (United States)

    Hamilton, David B.; Andrews, Austin K.; Auble, Gregor T.; Ellison, Richard A.; Farmer, Adrian H.; Roelle, James E.


    In the early 1960's, the National Aeronautics and Space Administration (NASA) began purchasing 140,000 acres on Merritt Island, Florida, in order to develop a center for space exploration. Most of this land was acquired to provide a safety and security buffer around NASA facilities. NASA, as the managing agency for the Kennedy Space Center (KSC), is responsible for preventing or controlling environmental pollution from the Federal facilities and activities at the Space Center and is committed to use all practicable means to protect and enhance the quality of the surrounding environment. The Merritt Island National Wildlife Refuge was established in 1963 when management authority for undeveloped lands at KSC was transferred to the U.S. Fish and Wildlife Service. In addition to manage for 11 Federally-listed threatened and endangered species and other resident and migratory fish and wildlife populations, the Refuge has comanagement responsibility for 19,000 acres of mosquito control impoundments and 2,500 acres of citrus groves. The Canaveral National Seashore was developed in 1975 when management of a portion of the coastal lands was transferred from NASA to the National Park Service. This multiagency jurisdiction on Merritt Island has resulted in a complex management environment. The modeling workshop described in this report was conducted May 21-25, 1984, at the Kennedy Space Center to: (1) enhance communication among the agencies with management responsibilities on Merritt Island; (2) integrate available information concerning the development, management, and ecology of Merritt Island; and (3) identify key research and monitoring needs associated with the management and use of the island's resources. The workshop was structured around the formulation of a model that would simulate primary management and use activities on Merritt Island and their effects on upland, impoundment, and estuarine vegetation and associated wildlife. The simulation model is composed of

  3. New Horizons at Pluto: An Overview of Educational Activities / Outreach at Fernbank Science Center, Atlanta, Georgia (USA) (United States)

    Albin, Edward F.; Harris, R. Scott


    We report on educational activities and associated outreach at Fernbank Science Center (Atlanta, GA) in conjunction with the July 2015 New Horizons spacecraft encounter at Pluto. On encounter day, a public lecture about the dwarf planet was presented by Georgia’s NASA Solar System ambassador to kick off the arrival of the space probe at Pluto. In the months following the flyby, we presented a program called “Exploring New Horizons” in the Science Center’s Zeiss planetarium. This program is a digital full-dome presentation about the discovery of Pluto and its subsequent exploration - including an overview of the New Horizons mission. Since NASA continues to receive data from the probe, a brief update (tribute) is included at the end of each planetarium program that features the latest imagery and data from the dwarf planet. We anticipate running the planetarium program throughout the fall semester of 2015. With Pluto visible in the early evening autumn sky, observations are possible with Center’s 0.9 m telescope, which is open for public viewing on clear Thursday and Friday nights following the planetarium program. Although Pluto is somewhat faint through the telescope's eyepiece, it is visible and clearly identified within the surrounding starfield. Intermittent post-encounter lectures ("Messages from the Outer Solar System") have been given on Friday evenings as well. Finally, due to the continued interest in Pluto, we have developed a new outreach program about dwarf planets in general, geared towards 4th - 6th students.

  4. Lessons learned from four years of actively using River Forecast Center Ensemble Streamflow Predictions to inform reservoir management (United States)

    Polebitski, A.; Palmer, R.; Meaker, B.


    The National Weather Service's River Forecast Centers (RFCs), located throughout the US, produce operational streamflow forecasts for short term application and long-term lead forecasts at selected locations. These forecasts are targeted for a variety of users, including water supply management, flood control, hydropower production, navigation, and recreation. This presentation highlights the challenges and successes associated with the use of RFC produced ensemble streamflow predictions (ESP) in generating system operations forecasts over the past four years for Snohomish County Public Utility District #1's (SnoPUD) Henry Jackson hydropower system. This research documents a multiyear collaboration between SnoPUD and academic researchers. The collaboration began with a proof of concept study in 2007 and evolved into a weekly decision support activity that has been ongoing since 2008 ( documented in Alemu et al. 2010). The Alemu et al. paper demonstrates the usefulness of ESP forecasts in hydropower operations decision making. This paper focuses on the value of forecasts and a decision support system (DSS) in improving skills in operating reservoir systems. During the application period, the model provided weekly guidance on meeting operational objectives and a probabilistic approach to quantifying system vulnerability during critical periods such as floods and drought. The ESP forecasts and the DSS were heavily used during periods of uncertainty and less so during periods of high system constraint or low system risk.

  5. Structures and Metal-Binding Properties of Helicobacter pylori Neutrophil-Activating Protein with a Di-Nuclear Ferroxidase Center

    Directory of Open Access Journals (Sweden)

    Hideshi Yokoyama


    Full Text Available Helicobacter pylori causes severe diseases, such as chronic gastritis, peptic ulcers, and stomach cancers. H. pylori neutrophil-activating protein (HP-NAP is an iron storage protein that forms a dodecameric shell, promotes the adhesion of neutrophils to endothelial cells, and induces the production of reactive oxygen radicals. HP-NAP belongs to the DNA-protecting proteins under starved conditions (Dps family, which has significant structural similarities to the dodecameric ferritin family. The crystal structures of the apo form and metal-ion bound forms, such as iron, zinc, and cadmium, of HP-NAP have been determined. This review focused on the structures and metal-binding properties of HP-NAP. These metal ions bind at the di-nuclear ferroxidase center (FOC by different coordinating patterns. In comparison with the apo structure, metal loading causes a series of conformational changes in conserved residues among HP-NAP and Dps proteins (Trp26, Asp52, and Glu56 at the FOC. HP-NAP forms a spherical dodecamer with 23 symmetry including two kinds of pores. Metal ions have been identified around one of the pores; therefore, the negatively-charged pore is suitable for the passage of metal ions.

  6. Origin of the catalytic activity of face-centered-cubic ruthenium nanoparticles determined from an atomic-scale structure. (United States)

    Kumara, L S R; Sakata, Osami; Kohara, Shinji; Yang, Anli; Song, Chulho; Kusada, Kohei; Kobayashi, Hirokazu; Kitagawa, Hiroshi


    The 3-dimensional (3D) atomic-scale structure of newly discovered face-centered cubic (fcc) and conventional hexagonal close packed (hcp) type ruthenium (Ru) nanoparticles (NPs) of 2.2 to 5.4 nm diameter were studied using X-ray pair distribution function (PDF) analysis and reverse Monte Carlo (RMC) modeling. Atomic PDF based high-energy X-ray diffraction measurements show highly diffuse X-ray diffraction patterns for fcc- and hcp-type Ru NPs. We here report the atomic-scale structure of Ru NPs in terms of the total structure factor and Fourier-transformed PDF. It is found that the respective NPs have substantial structural disorder over short- to medium-range order atomic distances from the PDF analysis. The first-nearest-neighbor peak analyses show a significant size dependence for the fcc-type Ru NPs demonstrating the increase in the peak height due to an increase in the number density as a function of particle size. The bond angle and coordination number (CN) distribution for the RMC-simulated fcc- and hcp-type Ru NP models indicated inherited structural features from their bulk counterparts. The CN analysis of the whole NP and surface of each RMC model of Ru NPs show the low activation energy packing sites on the fcc-type Ru NP surface atoms. Finally, our newly defined order parameters for RMC simulated Ru NP models suggested that the enhancement of the CO oxidation activity of fcc-type NPs was due to a decrease in the close packing ordering that resulted from the increased NP size. These structural findings could be positively supported for synthesized low-cost and high performance nano-sized catalysts and have potential application in fuel-cell systems and organic synthesis.

  7. A Broadly-Based Training Program in Volcano Hazards Monitoring at the Center for the Study of Active Volcanoes (United States)

    Thomas, D. M.; Bevens, D.


    The Center for the Study of Active Volcanoes, in cooperation with the USGS Volcano Hazards Program at HVO and CVO, offers a broadly based volcano hazards training program targeted toward scientists and technicians from developing nations. The program has been offered for 25 years and provides a hands-on introduction to a broad suite of volcano monitoring techniques, rather than detailed training with just one. The course content has evolved over the life of the program as the needs of the trainees have changed: initially emphasizing very basic monitoring techniques (e.g. precise leveling, interpretation of seismic drum records, etc.) but, as the level of sophistication of the trainees has increased, training in more advanced technologies has been added. Currently, topics of primary emphasis have included volcano seismology and seismic networks; acquisition and modeling of geodetic data; methods of analysis and monitoring of gas geochemistry; interpretation of volcanic deposits and landforms; training in LAHARZ, GIS mapping of lahar risks; and response to and management of volcanic crises. The course also provides training on public outreach, based on CSAV's Hawaii-specific hazards outreach programs, and volcano preparedness and interactions with the media during volcanic crises. It is an intensive eight week course with instruction and field activities underway 6 days per week; it is now offered in two locations, Hawaii Island, for six weeks, and the Cascades volcanoes of the Pacific Northwest, for two weeks, to enable trainees to experience field conditions in both basaltic and continental volcanic environments. The survival of the program for more than two decades demonstrates that a need for such training exists and there has been interaction and contribution to the program by the research community, however broader engagement with the latter continues to present challenges. Some of the reasons for this will be discussed.

  8. A Problem Solving Curriculum for Active Learning at the Northwest Center for Medical Education, Indiana University School of Medicine. (United States)

    Iatridis, Panayotis G.

    An innovative curriculum called the "Regional Center Alternative Pathway," recently adopted by the Northwest Center for Medical Education (part of Indiana University's School of Medicine), is presented. The curriculum combines the traditional structure's didactic approach with a new problem-based tutorial curriculum. In this curriculum…

  9. The hadronic origin of multi-TeV gamma rays from low-luminosity active galactic nuclei: implications of past activities of the Galactic center

    CERN Document Server

    Fujita, Yutaka; Murase, Kohta


    Radiatively inefficient accretion flows (RIAFs) in low-luminosity active galactic nuclei (LLAGNs) have been suggested as cosmic-ray and neutrino sources, which may largely contribute to the observed diffuse neutrino intensity. We show that this scenario naturally predicts hadronic multi-TeV gamma-ray excesses around galactic centers. The protons accelerated in the RIAF in Sagittarius A* (Sgr A*) escape and interact with dense molecular gas surrounding Sgr A*, which is known as the Central Molecular Zone (CMZ), and produce gamma rays as well as neutrinos. Based on a theoretical model that is compatible with the IceCube data, we calculate gamma-ray spectra of the CMZ and find that the gamma rays with $\\gtrsim 1$~TeV may have already been detected with the High Energy Stereoscopic System (HESS), if Sgr A* was more active in the past than it is today as indicated by various observations. Our model predicts that neutrinos should come from the CMZ with a spectrum similar to the gamma-ray spectrum. We also show that...

  10. Student Center Activities Aligned to the Common Core State Standards in English Language Arts and Literacy in History/Social Studies, Science, and Technical Subjects K-5 (United States)

    Verhagen, Connie


    This publication helps educators create differentiated reading instruction experiences for their students by showing the relationship between two distinct resources: Student Center Activities (SCAs) and the Common Core State Standards (CCSSs). Reading specialists, reading coaches, and teachers will find this document useful in lesson planning, as…

  11. Analysis According to Certain Variables of Scientific Literacy among Gifted Students That Participate in Scientific Activities at Science and Art Centers (United States)

    Kömek, Emre; Yagiz, Dursun; Kurt, Murat


    The purpose of this study is to analyze scientific literacy levels relevant to science and technology classes among gifted students that participate in scientific activities at science and art centers. This study investigated whether there was a significant difference in scientific literacy levels among gifted students according to the areas of…

  12. Use of a Cataloging Center's Bibliographic Records as a Means to Check and Balance Acquisitions Activities at an Academic Health Sciences Library. Report No. 63. (United States)

    Bristor, Patricia R.

    The acquisitions staff at Wayne State University's Shiffman Medical Library has developed a validation system based on the requests for cataloging from the five teaching hospitals which are members of the Detroit Cooperative Cataloging Center (DC3). Located at Shiffman, DC3 provides data on members' acquisition activities which have assisted in…



    Tolstova, A.


    In the clause the basic advantages of creation of an innovative conglomerate «The is innovative-technological center of development of transport system of Ukraine» are considered, the technique of determination of economic benefit of its activity is developed.

  14. Centro Regional de Ciencias Nucleares (a Brazilian regional center for nuclear sciences) - activities report - 1999; Centro Regional de Ciencias Nucleares - relatorio de atividades - 1999

    Energy Technology Data Exchange (ETDEWEB)



    The annual activities report of 1999 of nuclear sciences regional center - Brazilian organization - introduces the next main topics: institutional relations; sectorial actions - logistic support and training, laboratory of radiation protection and dosimetry, laboratory of metrology, laboratory of chemical characterization; technical and scientific events; and financial resources and perspectives for 2000.

  15. Site Energies of Active and Inactive Pheophytins in the Reaction Center of Photosystem II from Chlamydomonas Reinhardtii

    Energy Technology Data Exchange (ETDEWEB)

    Acharya, K.; Neupane, B.; Zazubovich, V.; Sayre, R. T.; Picorel, R.; Seibert, M.; Jankowiak, R.


    It is widely accepted that the primary electron acceptor in various Photosystem II (PSII) reaction center (RC) preparations is pheophytin {alpha} (Pheo {alpha}) within the D1 protein (Pheo{sub D1}), while Pheo{sub D2} (within the D2 protein) is photochemically inactive. The Pheo site energies, however, have remained elusive, due to inherent spectral congestion. While most researchers over the past two decades placed the Q{sub y}-states of Pheo{sub D1} and Pheo{sub D2} bands near 678-684 and 668-672 nm, respectively, recent modeling [Raszewski et al. Biophys. J. 2005, 88, 986-998; Cox et al. J. Phys. Chem. B 2009, 113, 12364-12374] of the electronic structure of the PSII RC reversed the assignment of the active and inactive Pheos, suggesting that the mean site energy of Pheo{sub D1} is near 672 nm, whereas Pheo{sub D2} ({approx}677.5 nm) and Chl{sub D1} ({approx}680 nm) have the lowest energies (i.e., the Pheo{sub D2}-dominated exciton is the lowest excited state). In contrast, chemical pigment exchange experiments on isolated RCs suggested that both pheophytins have their Q{sub y} absorption maxima at 676-680 nm [Germano et al. Biochemistry 2001, 40, 11472-11482; Germano et al. Biophys. J. 2004, 86, 1664-1672]. To provide more insight into the site energies of both Pheo{sub D1} and Pheo{sub D2} (including the corresponding Q{sub x} transitions, which are often claimed to be degenerate at 543 nm) and to attest that the above two assignments are most likely incorrect, we studied a large number of isolated RC preparations from spinach and wild-type Chlamydomonas reinhardtii (at different levels of intactness) as well as the Chlamydomonas reinhardtii mutant (D2-L209H), in which the active branch Pheo{sub D1} is genetically replaced with chlorophyll {alpha} (Chl {alpha}). We show that the Q{sub x}-/Q{sub y}-region site energies of Pheo{sub D1} and Pheo{sub D2} are {approx}545/680 nm and {approx}541.5/670 nm, respectively, in good agreement with our previous assignment

  16. Evaluation of Anatomical and Functional Hip Joint Center Methods: The Effects of Activity Type, Gender, and Proximal Reference Segment. (United States)

    McGibbon, C A; Fowler, J; Chase, S; Steeves, K; Landry, J; Mohamed, A


    Accurate hip joint center (HJC) location is critical when studying hip joint biomechanics. The HJC is often determined from anatomical methods, but functional methods are becoming increasingly popular. Several studies have examined these methods using simulations and in vivo gait data, but none has studied high-range of motion activities, such a chair rise, nor has HJC prediction been compared between males and females. Furthermore, anterior superior iliac spine (ASIS) marker visibility during chair rise can be problematic, requiring a sacral cluster as an alternative proximal segment; but functional HJC has not been explored using this approach. For this study, the quality of HJC measurement was based on the joint gap error (JGE), which is the difference in global HJC between proximal and distal reference segments. The aims of the present study were to: (1) determine if JGE varies between pelvic and sacral referenced HJC for functional and anatomical methods, (2) investigate which functional calibration motion results in the lowest JGE and if the JGE varies depending on movement type (gait versus chair rise) and gender, and (3) assess whether the functional HJC calibration results in lower JGE than commonly used anatomical approaches and if it varies with movement type and gender. Data were collected on 39 healthy adults (19 males and 20 females) aged 14-50 yr old. Participants performed four hip "calibration" tests (arc, cross, star, and star-arc), as well as gait and chair rise (activities of daily living (ADL)). Two common anatomical methods were used to estimate HJC and were compared to HJC computed using a published functional method with the calibration motions above, when using pelvis or sacral cluster as the proximal reference. For ADL trials, functional methods resulted in lower JGE (12-19 mm) compared to anatomical methods (13-34 mm). It was also found that women had significantly higher JGE compared to men and JGE was significantly higher for

  17. Site energies of active and inactive pheophytins in the reaction center of Photosystem II from Chlamydomonas reinhardtii. (United States)

    Acharya, K; Neupane, B; Zazubovich, V; Sayre, R T; Picorel, R; Seibert, M; Jankowiak, R


    It is widely accepted that the primary electron acceptor in various Photosystem II (PSII) reaction center (RC) preparations is pheophytin a (Pheo a) within the D1 protein (Pheo(D1)), while Pheo(D2) (within the D2 protein) is photochemically inactive. The Pheo site energies, however, have remained elusive, due to inherent spectral congestion. While most researchers over the past two decades placed the Q(y)-states of Pheo(D1) and Pheo(D2) bands near 678-684 and 668-672 nm, respectively, recent modeling [Raszewski et al. Biophys. J. 2005, 88, 986 - 998; Cox et al. J. Phys. Chem. B 2009, 113, 12364 - 12374] of the electronic structure of the PSII RC reversed the assignment of the active and inactive Pheos, suggesting that the mean site energy of Pheo(D1) is near 672 nm, whereas Pheo(D2) (~677.5 nm) and Chl(D1) (~680 nm) have the lowest energies (i.e., the Pheo(D2)-dominated exciton is the lowest excited state). In contrast, chemical pigment exchange experiments on isolated RCs suggested that both pheophytins have their Q(y) absorption maxima at 676-680 nm [Germano et al. Biochemistry 2001, 40, 11472 - 11482; Germano et al. Biophys. J. 2004, 86, 1664 - 1672]. To provide more insight into the site energies of both Pheo(D1) and Pheo(D2) (including the corresponding Q(x) transitions, which are often claimed to be degenerate at 543 nm) and to attest that the above two assignments are most likely incorrect, we studied a large number of isolated RC preparations from spinach and wild-type Chlamydomonas reinhardtii (at different levels of intactness) as well as the Chlamydomonas reinhardtii mutant (D2-L209H), in which the active branch Pheo(D1) is genetically replaced with chlorophyll a (Chl a). We show that the Q(x)-/Q(y)-region site energies of Pheo(D1) and Pheo(D2) are ~545/680 nm and ~541.5/670 nm, respectively, in good agreement with our previous assignment [Jankowiak et al. J. Phys. Chem. B 2002, 106, 8803 - 8814]. The latter values should be used to model excitonic

  18. Basic and clinical research on the regulation of the intestinal barrier by Lactobacillus and its active protein components: a review with experience of one center. (United States)

    Liu, Zhi-Hua; Kang, Liang; Wang, Jian-Ping


    Probiotics got protective effects on the intestinal barrier. Our present study is to review the basic and clinical progress on the regulation of the intestinal barrier by Lactobacillus and its active protein components, combing the study of our center. Our study have isolated the active component of micro integral membrane protein (MIMP) within the media place of the integral membrane protein of Lactobacillus plantarum, which was verified about the protective effects against the intestinal epithelial dysfunction. On the other hand, we also found the effects of perioperative use of probiotics in the prevention and treatment of postoperative intestinal barrier dysfunction, and reduction of the postoperative infective complications. In this review, we would like to report the founding of our center, involving in the basic and clinical research progress of regulation of intestinal barrier by Lactobacillus and its active protein component MIMP. Furthermore, we may also promote our following studies about the MIMP and its clinical verification.

  19. The germinal center kinase GCK-1 is a negative regulator of MAP kinase activation and apoptosis in the C. elegans germline.

    Directory of Open Access Journals (Sweden)

    Katherine R Schouest

    Full Text Available The germinal center kinases (GCK constitute a large, highly conserved family of proteins that has been implicated in a wide variety of cellular processes including cell growth and proliferation, polarity, migration, and stress responses. Although diverse, these functions have been attributed to an evolutionarily conserved role for GCKs in the activation of ERK, JNK, and p38 MAP kinase pathways. In addition, multiple GCKs from different species promote apoptotic cell death. In contrast to these paradigms, we found that a C. elegans GCK, GCK-1, functions to inhibit MAP kinase activation and apoptosis in the C. elegans germline. In the absence of GCK-1, a specific MAP kinase isoform is ectopically activated and oocytes undergo abnormal development. Moreover, GCK-1- deficient animals display a significant increase in germ cell death. Our results suggest that individual germinal center kinases act in mechanistically distinct ways and that these functions are likely to depend on organ- and developmental-specific contexts.

  20. Effects of supported (nBuCp)2ZrCl2 catalyst active center multiplicity on crystallization kinetics of ethylene homo- and copolymers

    KAUST Repository

    Atiqullah, Muhammad


    Two different supported zirconocene, that is, bis(n-butylcyclopentadienyl) zirconium dichloride (nBuCp)2ZrCl2, catalysts were synthesized. Each catalyst was used to prepare one ethylene homopolymer and one ethylene-1-hexene copolymer. Catalyst active center multiplicity and polymer crystallization kinetics were modeled. Five separate active center types were predicted, which matched the successive self-nucleation and annealing (SSA) peak temperatures. The predicted crystallinity well matched the differential scanning calorimetric (DSC) values for a single Avrami-Erofeev index, which ranged between 2 and 3 for the polymers experimented. The estimated apparent crystallization activation energy Ea did not vary with cooling rates, relative crystallinity α, and crystallization time or temperature. Therefore, the concept of variable/instantaneous activation energy was not found to hold. Ea linearly increased with the weight average lamellar thickness Lwav DSC-GT; and for each homopolymer, it exceeded that of the corresponding copolymer. Higher Ea, hence slower crystallization, was identified as a pre-requisite to attain higher crystallinity. Crystallization parameters were correlated to polymer backbone parameters, which are influenced by catalyst active center multiplicity. © 2013 Taiwan Institute of Chemical Engineers.

  1. Silica-supported (nBuCp)2ZrCl2: Effect of catalyst active center distribution on ethylene-1-hexene copolymerization

    KAUST Repository

    Atiqullah, Muhammad


    Metallocenes are a modern innovation in polyolefin catalysis research. Therefore, two supported metallocene catalysts-silica/MAO/(nBuCp)2ZrCl2 (Catalyst 1) and silica/nBuSnCl3/MAO/(nBuCp)2ZrCl2 (Catalyst 2), where MAO is methylaluminoxane-were synthesized, and subsequently used to prepare, without separate feeding of MAO, ethylene-1-hexene Copolymer 1 and Copolymer 2, respectively. Fouling-free copolymerization, catalyst kinetic stability and production of free-flowing polymer particles (replicating the catalyst particle size distribution) confirmed the occurrence of heterogeneous catalysis. The catalyst active center distribution was modeled by deconvoluting the measured molecular weight distribution and copolymer composition distribution. Five different active center types were predicted for each catalyst, which was corroborated by successive self-nucleation and annealing experiments, as well as by an extended X-ray absorption fine structure spectroscopy report published in the literature. Hence, metallocenes impregnated particularly on an MAO-pretreated support may be rightly envisioned to comprise an ensemble of isolated single sites that have varying coordination environments. This study shows how the active center distribution and the design of supported MAO anions affect copolymerization activity, polymerization mechanism and the resulting polymer microstructures. Catalyst 2 showed less copolymerization activity than Catalyst 1. Strong chain transfer and positive co-monomer effect-both by 1-hexene-were common. Each copolymer demonstrated vinyl, vinylidene and trans-vinylene end groups, and compositional heterogeneity. All these findings were explained, as appropriate, considering the modeled active center distribution, MAO cage structure repeat units, proposed catalyst surface chemistry, segregation effects and the literature that concerns and supports this study. While doing so, new insights were obtained. Additionally, future research, along the direction

  2. Excel Center

    Institute of Scientific and Technical Information of China (English)


    Citigroup,one of the World top 500 companies,has now settled in Excel Center,Financial Street. The opening ceremony of Excel Center and the entry ceremony of Citigroup in the center were held on March 31.Government leaders of Xicheng District,the Excel CEO and the heads of Asia-Pacific Region leaders of Citibank all participated in the ceremony.

  3. Rhyolitic calderas and centers clustered within the active andesitic belt of Ecuador's Eastern Cordillera

    Energy Technology Data Exchange (ETDEWEB)

    Mothes, Patricia A; Hall, Minard L [Instituto Geofisico, Escuela Politecnica Nacional, Quito (Ecuador)], E-mail:


    In the Ecuadorian volcanic arc a cluster of scattered rhyolitic and dacitic centers within the mainly andesitic Eastern Cordillera includes large caldera structures (Chalupas, Chacana, Cosanga) as well as smaller edifices, built upon the Paleozoic-Mesozoic metamorphic basement. At the Chacana caldera magmatism dates from 2.7 Ma to historic times. These centers erupted enormous ash flows and thick pumice lapilli falls that covered the InterAndean Valley near Quito. The role of the 50-70 km-thick crust with a notable negative gravity anomaly appears to be related to the generation of this highly silicic magmatism occurring along the crest of the Andes in the NVZ.

  4. Reconstituting redox active centers of heme-containing proteins with biomineralized gold toward peroxidase mimics with strong intrinsic catalysis and electrocatalysis for H2O2 detection. (United States)

    Zhang, Liyan; Li, Shuai; Dong, Minmin; Jiang, Yao; Li, Ru; Zhang, Shuo; Lv, Xiaoxia; Chen, Lijun; Wang, Hua


    A facile and efficient enzymatic reconstitution methodology has been proposed for high-catalysis peroxidase mimics by remolding the redox active centers of heme-containing proteins with the in-site biomineralized gold using hemoglobin (Hb) as a model. Catalytic hemin (Hem) was extracted from the active centers of Hb for the gold biomineralization and then reconstituted into apoHb to yield the Hem-Au@apoHb nanocomposites showing dramatically improved intrinsic catalysis and electrocatalysis over natural Hb and Hem. The biomineralized gold, on the one hand, would act as "nanowires" to promote the electron transferring of the nanocomposites. On the other hand, it would create a reactivity pathway to pre-organize and accumulate more substrates towards the active sites of the peroxidase mimics. Steady-state kinetics studies indicate that Hem-Au@apoHb could present much higher substrate affinity (lower Michaelis constants) and intrinsic catalysis even than some natural peroxidases. Moreover, the application feasibility of the prepared artificial enzymes was demonstrated by colorimetric assays and direct electrocatalysis for H2O2 sensing, showing a detection limitation low as 0.45μM. Importantly, such a catalysis active-center reconstitution protocol may circumvent the substantial improvement of the intrinsic catalysis and electrocatalysis of diverse heme-containing proteins or enyzmes toward the extensive applications in the chemical, enviromental, and biomedical catalysis fields.

  5. Business Activity Monitoring: Real-Time Group Goals and Feedback Using an Overhead Scoreboard in a Distribution Center (United States)

    Goomas, David T.; Smith, Stuart M.; Ludwig, Timothy D.


    Companies operating large industrial settings often find delivering timely and accurate feedback to employees to be one of the toughest challenges they face in implementing performance management programs. In this report, an overhead scoreboard at a retailer's distribution center informed teams of order selectors as to how many tasks were…

  6. Method for Forming Copious (F sub 2(+))A Centers in Certain Stable, Broadly-Tunable Laser-Active Materials. (United States)

    iodide, Rubidium iodide lithium crystals and other comparable crystalline materials , especially materials doped with lithium (Li). A principal object of...ion centers in Kl:Li and RbI:Li, or in comparable crystalline materials ; by growing, coloring, and annealing the K::Li or the RbI:Li crystals in nitrogen-free inert (e.g., argon) atmospheres.

  7. Asymmetric Desymmetrization via Metal-Free C-F Bond Activation: Synthesis of 3,5-Diaryl-5-fluoromethyloxazolidin-2-ones with Quaternary Carbon Centers. (United States)

    Tanaka, Junki; Suzuki, Satoru; Tokunaga, Etsuko; Haufe, Günter; Shibata, Norio


    We disclose the first asymmetric activation of a non-activated aliphatic C-F bond in which a conceptually new desymmetrization of 1,3-difluorides by silicon-induced selective C-F bond scission is a key step. The combination of a cinchona alkaloid based chiral ammonium bifluoride catalyst and N,O-bis(trimethylsilyl)acetoamide (BSA) as the silicon reagent enabled the efficient catalytic cycle of asymmetric Csp3 -F bond cleavage under mild conditions with high enantioselectivities. The ortho effect of the aryl group at the prostereogenic center is remarkable. This concept was applied for the asymmetric synthesis of promising agrochemical compounds, 3,5-diaryl-5-fluoromethyloxazolidin-2-ones bearing a quaternary carbon center.

  8. Flip flops, dress clothes, and no coat: clothing barriers to children's physical activity in child-care centers identified from a qualitative study

    Directory of Open Access Journals (Sweden)

    Saelens Brian E


    Full Text Available Abstract Background Three-quarters of 3-6 year-old children in the U.S. spend time in childcare; many spend most of their waking hours in these settings. Daily physical activity offers numerous health benefits, but activity levels vary widely across centers. This study was undertaken to explore reasons why physical activity levels may vary. The purpose of this paper is to summarize an unexpected finding that child-care providers cited was a key barrier to children's physical activity. Methods Nine focus groups with 49 child-care providers (55% black from 34 centers (including inner-city, suburban, Head Start and Montessori were conducted in Cincinnati, OH. Three independent raters analyzed verbatim transcripts for themes. Several techniques were used to increase credibility of findings, including interviews with 13 caregivers. Results Two major themes about clothing were: 1 children's clothing was a barrier to children's physical activity in child-care, and 2 clothing choices were a significant source of conflict between parents and child-care providers. Inappropriate clothing items included: no coat/hat/gloves in the wintertime, flip flops or sandals, dress/expensive clothes, jewelry, and clothes that were either too loose or too tight. Child-care providers explained that unless there were enough extra coats at the center, a single child without a coat could prevent the entire class from going outside. Caregivers suggested several reasons why parents may dress their child inappropriately, including forgetfulness, a rushed morning routine, limited income to buy clothes, a child's preference for a favorite item, and parents not understanding the importance of outdoor play. Several child-care providers favored specific policies prohibiting inappropriate clothing, as many reported limited success with verbal or written reminders to bring appropriate clothing. Conclusion Inappropriate clothing may be an important barrier to children's physical

  9. Synthesis of budgeting and accounting standard method for «responsibility centers» as information engineering base of operating activities of enterprise

    Directory of Open Access Journals (Sweden)

    I.A. Herasymovych


    Full Text Available Market conditions have caused the necessity of introduction at Ukrainian enterprises such a new economic mechanism as financial engineering based on the new approach of synthesis budgeting, «responsibility centers» and managerial accounting by the statutory method in the option of «Direct-costing» (direct costs. The new register «Report of the responsibility center about the work of the pair» which is created in direct costs, is offered for controlling of indexes of the proven budgets about their actual implementation. The main results of the research are: the clear definition of «centers of responsibility» and liability of managers for each item of estimates (budget; the creation of the accounting data signal system about the deviations from standards and changing of the budget norms; the development of operational, accounting records for daily cost accounting; the development of the graphs of document flow on each «responsibility center», which will provide the drafting of internal reporting for implementation of informational indicators, which give an opportunity to evaluate and to control, to predict and to plan the «responsibility centers» activity of an enterprise and also of some of its managers. Scientific novelty and practical value lie in the capacity of «Direct-costing» in terms of financial engineering: 1 it provides rapid determination of budget implementation and the actual cost of production; 2 it allows to determine the «break-even point» which enables to regulate it by options for varying the direct costs or volume and price for selling; 3 according to this method there is no necessity to allocate managerial fixed costs for types of products, as we cannot include them into the results of an enterprise activity.

  10. The 3 Ms Chandra Campaign on Sgr A*: A Census of X-ray Flaring Activity from the Galactic Center

    CERN Document Server

    Neilsen, J; Gammie, C; Dexter, J; Markoff, S; Haggard, D; Nayakshin, S; Wang, Q D; Grosso, N; Porquet, D; Tomsick, J A; Degenaar, N; Fragile, P C; Houck, J C; Wijnands, R; Miller, J M; Baganoff, F K


    Over the last decade, X-ray observations of Sgr A* have revealed a black hole in a deep sleep, punctuated roughly once per day by brief flares. The extreme X-ray faintness of this supermassive black hole has been a long-standing puzzle in black hole accretion. To study the accretion processes in the Galactic Center, Chandra (in concert with numerous ground- and space-based observatories) undertook a 3 Ms campaign on Sgr A* in 2012. With its excellent observing cadence, sensitivity, and spectral resolution, this Chandra X-ray Visionary Project (XVP) provides an unprecedented opportunity to study the behavior of the closest supermassive black hole. We present a progress report from our ongoing study of X-ray flares, including the brightest flare ever seen from Sgr A*. Focusing on the statistics of the flares and the quiescent emission, we discuss the physical implications of X-ray variability in the Galactic Center.


    Directory of Open Access Journals (Sweden)

    Isimbaev Erkin


    Full Text Available The authors discuss the experience of the educational adult center in the context of the idea - "education throughout the life". In the frame of the last three years the Centre organized the monitoring and analytical work to create a system of education and finding ways to improve the efficiency of working with people of "the third age". The article presents the facts and analytical conclusions on the results of the monitoring.

  12. Center Innovation Fund Program (United States)

    National Aeronautics and Space Administration — To stimulate and encourage creativity and innovation within the NASA Centers. The activities are envisioned to fall within the scope of NASA Space Technology or...

  13. Center for Beam Physics, 1992

    Energy Technology Data Exchange (ETDEWEB)


    This report contains the following information on the center for beam physics: Facilities; Organizational Chart; Roster; Profiles of Staff; Affiliates; Center Publications (1991--1993); and 1992 Summary of Activities.

  14. Italy INAF Data Center Report (United States)

    Negusini, M.; Sarti, P.


    This report summarizes the activities of the Italian INAF VLBI Data Center. Our Data Center is located in Bologna, Italy and belongs to the Institute of Radioastronomy, which is part of the National Institute of Astrophysics.

  15. Distribution center

    Institute of Scientific and Technical Information of China (English)


    Distribution center is a logistics link fulfill physical distribution as its main functionGenerally speaking, it's a large and hiahly automated center destined to receive goods from various plants and suppliers,take orders,fill them efficiently,and deliver goods to customers as quickly as possible.

  16. The Discovery of Fermi Bubbles: Multi-wavelength Observations and Implications to the Past Activity of Galactic Center (United States)

    Su, Meng


    Data from the Fermi-LAT reveal two large gamma-ray bubbles, extending 50 degrees above and below the Galactic center, with a width of about 40 degrees in longitude. The gamma-ray emission associated with these bubbles has a significantly harder spectrum (dN/dE E-2) than the IC emission from electrons in the Galactic disk, or the gamma-rays produced by decay of pions from proton-ISM collisions. The bubbles are spatially correlated with the hard-spectrum microwave excess known as the WMAP haze; the edges of the bubbles also line up with features in the ROSAT X-ray maps at 1.5 - 2 keV. We further discovered arge cocoon structures in Fermi gamma-ray data, which is presumably produced by relativistic large scale jets. I will summarize observational evidence of the Fermi bubbles and cocoons, including features of polarization and rotation measure of the bubble edges. The bubbles have sharp edges in gamma-ray, X-ray, and polarized microwave emission. I'm going to argue that these Galactic gamma-ray bubbles are ongoing shocks (instead of a stable structure), and were most likely created by some large episode of energy injection in the Galactic center, such as past accretion events onto the central massive black hole, or a nuclear starburst in the last ˜10 Myr.

  17. Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease. (United States)

    Perry, George; Taddeo, Marta A; Petersen, Robert B; Castellani, Rudy J; Harris, Peggy L R; Siedlak, Sandra L; Cash, Adam D; Liu, Quan; Nunomura, Akohiko; Atwood, Craig S; Smith, Mark A


    Central to oxidative damage in Alzheimer disease is the production of metal-catalyzed hydroxyl radicals that damage every category of macromolecule. Studies on redox-competent copper and iron indicate that redox activity in Alzheimer disease resides exclusively within the cytosol of vulnerable neurons and that chelation with deferoxamine or DTPA removes this activity. We have also found that while proteins that accumulate in Alzheimer disease such as tau, amyloid beta, and apolipoprotein E possess metal-binding sites, metal-associated cellular redox activity is more dependent on metal-nucleic acid binding. Consistent with this finding is the large amount of cytoplasmic RNA in pyramidal neurons. Still, the source of metal-catalyzed redox activity is controversial. Heme oxygenase-1, an enzyme that catalyzes the conversion of heme to iron and biliverdin, is increased in Alzheimer disease suggesting increased heme turnover as a source of redox-active iron. Additionally, the role of mitochondria as a potential source of redox-active metals and oxygen radical production is assuming more prominence. In recent studies, we have found that while mitochondrial DNA and cytochrome C oxidase activity are increased in Alzheimer disease, the number of mitochondria is decreased, indicating accelerated mitochondria turnover. This finding, as well as preliminary studies demonstrating a reduction in microtubule density in neurons in Alzheimer disease suggests mitochondrial dysfunction as a potentially inseparable component of the initiation and progression of Alzheimer disease.

  18. Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension. (United States)

    Marcotte, Douglas; Rushe, Mia; M Arduini, Robert; Lukacs, Christine; Atkins, Kateri; Sun, Xin; Little, Kevin; Cullivan, Michael; Paramasivam, Murugan; Patterson, Thomas A; Hesson, Thomas; D McKee, Timothy; May-Dracka, Tricia L; Xin, Zhili; Bertolotti-Ciarlet, Andrea; Bhisetti, Govinda R; Lyssikatos, Joseph P; Silvian, Laura F


    Germinal-center kinase-like kinase (GLK, Map4k3), a GCK-I family kinase, plays multiple roles in regulating apoptosis, amino acid sensing, and immune signaling. We describe here the crystal structure of an activation loop mutant of GLK kinase domain bound to an inhibitor. The structure reveals a weakly associated, activation-loop swapped dimer with more than 20 amino acids of ordered density at the carboxy-terminus. This C-terminal PEST region binds intermolecularly to the hydrophobic groove of the N-terminal domain of a neighboring molecule. Although the GLK activation loop mutant crystallized demonstrates reduced kinase activity, its structure demonstrates all the hallmarks of an "active" kinase, including the salt bridge between the C-helix glutamate and the catalytic lysine. Our compound displacement data suggests that the effect of the Ser170Ala mutation in reducing kinase activity is likely due to its effect in reducing substrate peptide binding affinity rather than reducing ATP binding or ATP turnover. This report details the first structure of GLK; comparison of its activation loop sequence and P-loop structure to that of Map4k4 suggests ideas for designing inhibitors that can distinguish between these family members to achieve selective pharmacological inhibitors.

  19. 物流中心作业成本通用模型研究%General Activity-based Cost Model for Logistics Center

    Institute of Scientific and Technical Information of China (English)

    朱燕春; 李洋


    为了实现流通企业物流中心的精细化成本管理,在分析作业成本法原理的基础上,结合流通企业物流中心的业务流程及其生产成本构成特点,本文构建了物流中心作业成本通用模型,并对通用模型中资源池的建立、作业池模型设计、确认成本核算对象、成本动因模型设计四大主要环节的成本核算过程和方法进行了研究和阐述,最后通过实例说明了作业成本法的应用.%In order to realize fine cost accounting and management in logistic center of circulation enterprise, with the analysis of the basic principles of Activity-based Costing as well as the combination of the operation process of the logistic center and the characteristics of its cost structure, this paper constructs a general model for the activity-based costs of logistic center, in this model, we will study and elaborate the process and method of cost accounting which consists of four links of the establishment of resource pool, the designing of activity pool model, the confirmation of cost accounting object and the designing of cost driver model and finally exemplify the application of ABC.

  20. Binding stability of peptides derived from 1ALA residue and 7GLY residues to sites near active center of fluctuating papain (United States)

    Nishiyama, Katsuhiko


    We investigated the binding stability of peptides derived from 1ALA residue and 7GLY residues to sites near active center of fluctuating papain via molecular dynamics and docking simulations. Replacing GLY residue in 8GLY with ALA residue had a positive effect on binding stability to the sites in some cases although the replacing had a negative effect on it in other cases. Furthermore the replacing had a negative effect on the chance of binding to the sites. Residue in peptide should be replaced on the basis of systematic exploration of its position.

  1. Effects of Supported ( n BuCp) 2 ZrCl 2 Catalyst Active-Center Distribution on Ethylene–1-Hexene Copolymer Backbone Heterogeneity and Thermal Behaviors

    KAUST Repository

    Atiqullah, Muhammad


    Two catalysts, denoted as catalyst 1 [silica/MAO/(nBuCp) 2ZrCl2] and catalyst 2 [silica/nBuSnCl 3/MAO/(nBuCp)2ZrCl2] were synthesized and subsequently used to prepare, without separate feeding of methylaluminoxane (MAO), ethylene homopolymer 1 and homopolymer 2, respectively, and ethylene-1-hexene copolymer 1 and copolymer 2, respectively. Gel permeation chromatography (GPC), Crystaf, differential scanning calorimetry (DSC) [conventional and successive self-nucleation and annealing (SSA)], and 13C nuclear magnetic resonance (NMR) polymer characterization results were used, as appropriate, to model the catalyst active-center distribution, ethylene sequence (equilibrium crystal) distribution, and lamellar thickness distribution (both continuous and discrete). Five different types of active centers were predicted in each catalyst, as corroborated by the SSA experiments and complemented by an extended X-ray absorption fine structure (EXAFS) report published in the literature. 13C NMR spectroscopy also supported this active-center multiplicity. Models combined with experiments effectively illustrated how and why the active-center distribution and the variance in the design of the supported MAO anion, having different electronic and steric effects and coordination environments, influence the concerned copolymerization mechanism and polymer properties, including inter- and intrachain compositional heterogeneity and thermal behaviors. Copolymerization occurred according to the first-order Markovian terminal model, producing fairly random copolymers with minor skewedness toward blocky character. For each copolymer, the theoretical most probable ethylene sequences, nE MPDSC-GT and n E MPNMR-Flory, as well as the weight-average lamellar thicknesses, Lwav DSC-GT and Lwav SSA DSC, were found to be comparable. To the best of our knowledge, such a match has not previously been reported. The percentage crystallinities of the homo- and copolymers increased linearly as a function of

  2. Impact of body mass index, physical activity, and other clinical factors on cardiorespiratory fitness (from the Cooper Center longitudinal study). (United States)

    Lakoski, Susan G; Barlow, Carolyn E; Farrell, Stephen W; Berry, Jarett D; Morrow, James R; Haskell, William L


    Cardiorespiratory fitness (CRF) is widely accepted as an important reversible cardiovascular risk factor. In the present study, we examined the nonmodifiable and modifiable determinants of CRF within a large healthy Caucasian population of men and women. The study included 20,239 patients presenting to Cooper Clinic (Dallas, Texas) for a comprehensive medical examination from 2000 through 2010. CRF was determined by maximal treadmill exercise testing. Physical activity categories were 0 metabolic equivalent tasks (METs)/min/week (no self-reported moderate or vigorous intensity physical activity), 1 to 449 METs/min/week (not meeting physical activity guideline), 450 to 749 METs/min/week (meeting guideline), and ≥750 METs/min/week (exceeding guideline). Linear regression modeling was used to determine the most robust clinical factors associated with achieved treadmill time. Age, gender, body mass index (BMI), and physical activity were the most important factors associated with CRF, explaining 56% of the variance (R(2) = 0.56). The addition of all other factors combined (current smoking, systolic blood pressure, blood glucose, high-density and low-density lipoprotein cholesterol, health status) were associated with CRF (p physical activity on CRF, such that normal-weight (BMI physical activity compared to obese subjects (BMI ≥30 kg/m(2)). Percent body fat, not lean body mass, was the key factor driving this interaction. In conclusion, BMI was the most important clinical risk factor associated with CRF other than nonmodifiable risk factors age and gender. For a similar amount of physical activity, normal-weight subjects achieved a higher CRF level compared to obese subjects. These data suggest that obesity may offset the benefits of physical activity on achieved CRF, even in a healthy population of men and women.

  3. Evaluation of macrophage activation syndrome associated with systemic juvenile idiopathic arthritis: single center experience over a one-year period (United States)

    Barut, Kenan; Yücel, Gözde; Sinoplu, Ada Bulut; Şahin, Sezgin; Adroviç, Amra; Kasapçopur, Özgür


    Aim: This study aimed to evaluate the demographic, clinical, laboratory properties of patients with macrophage activation syndrome and treatment outcomes. Material and Methods: The data of the patients who were diagnosed with macrophage activation syndrome secondary to systemic juvenile idiopathic arthritis between June 2013–May 2014 were evaluated by screening patient records. Results: Ten patients with macrophage activation syndrome were followed up in one year. The mean age at the time of diagnosis was found to be 7.6±4.5 years. The most common clinical finding at presentation (80%) was increased body temperature. Hepatosplenomegaly was found in half of the patients. The most common hematological finding (90%) was anemia. The mean erythrocyte sedimentation rate was found to be 71.8±36.2 mm/h, whereas it was measured to be lower (31.2±25.2 mm/h) at the time of the diagnosis of macrophage activation syndrome. Increased ferritin level was found in all of our patients (the mean ferritin level was found to be 23 957±15 525 ng/mL). Hypertriglyceridemia was found in nine patients (90%). The mean triglyceride level was found to be 397±332 mg/dL. Systemic steroid treatment was administered to all patients. Cyclosporine A was given to eight patients (80%), canakinumab was given to four patients (40%) and anakinra was given to five patients (50%). Plasmapheresis was performed in two patients. Improvement was found in all patients except for one patient. The patient in whom no improvement was observed showed a chronic course. Conclusions: The diagnosis of macrophage activation syndrome should be considered in presence of sudden disturbance in general condition, resistant high fever and systemic inflammation findings in children with active rheumatic disease. Complete recovery can be provided with early and efficient treatment in macrophage activation syndrome which develops secondary to systemic juvenil idiopathic arthritis. PMID:26884689

  4. Organisational structure and its effect on the therapeutic activity and effectiveness in an american mental health center. (United States)

    Andersen, T


    The mental health center movement represents a new mode of care for the mentally ill. People are treated on an out-patient basis rather than in institutions. The therapeutic work is mainly carried out by so-called paraprofessionals who seem to be well qualified for the job. However, when organizing such a treatment system there appear to be several important factors which need to be taken into account: (1) the therapist's need to work individually and independently, (2) the therapist's need for personal training, (3) the therapist's need to be heard when they channel information from the community to the service system, (4) the need for open and direct communication in the system to ensure that the therapists work within the frame of accepted therapeutic procedures, (5) the importance of the therapists' being represented at the highest decision-making level in the system in order to ensure that their needs are met. The author stresses this as an inevitable necessitiy in order to give the therapists the appropriate working-background.

  5. Antenna Technology and other Radio Frequency (RF) Communications Activities at the Glenn Research Center in Support of NASA's Exploration Vision (United States)

    Miranda, Felix A.


    NASA s Vision for Space Exploration outlines a very ambitious program for the next several decades of the Space Agency endeavors. Ahead is the completion of the International Space Station (ISS); safely flight the shuttle (STS) until 2010; develop and fly the Crew Exploration Vehicle (Orion) by no later than 2014; return to the moon by no later than 2020; extend human presence across the solar system and beyond; implement a sustainable and affordable human and robotic program; develop supporting innovative technologies, knowledge and infrastructure; and promote international and commercial participation in exploration. To achieve these goals, a series of enabling technologies must be developed or matured in a timely manner. Some of these technologies are: spacecraft RF technology (e.g., high power sources and large antennas which using surface receive arrays can get up to 1 Gbps from Mars), uplink arraying (reduce reliance on large ground-based antennas and high operation costs; single point of failure; enable greater data-rates or greater effective distance; scalable, evolvable, flexible scheduling), software define radio (i.e., reconfigurable, flexible interoperability allows for in flight updates open architecture; reduces mass, power, volume), and optical communications (high capacity communications with low mass/power required; significantly increases data rates for deep space). This presentation will discuss some of the work being performed at the NASA Glenn Research Center, Cleveland, Ohio, in antenna technology as well as other on-going RF communications efforts.

  6. X-ray Diagnostics of Giant Molecular Clouds in the Galactic Center Region and Past Activity of Sgr A*

    CERN Document Server

    Odaka, Hirokazu; Watanabe, Shin; Tanaka, Yasuyuki; Khangulyan, Dmitry; Takahashi, Tadayuki; 10.1088/0004-637X/740/2/103


    Strong iron fluorescence at 6.4 keV and hard-X-ray emissions from giant molecular clouds in the Galactic center region have been interpreted as reflections of a past outburst of the Sgr A* supermassive black hole. Careful treatment of multiple interactions of photons in a complicated geometry is essential to modeling the reprocessed emissions from the dense clouds. We develop a new calculation framework of X-ray reflection from molecular clouds based on Monte Carlo simulations for accurate interpretation of high-quality observational data. By utilizing this simulation framework, we present the first calculations of morphologies and spectra of the reflected X-ray emission for several realistic models of Sgr B2, which is the most massive molecular cloud in our Galaxy. The morphology of scattered hard X-rays above 20 keV is significantly different from that of iron fluorescence due to their large penetrating power into dense regions of the cloud, probing the structure of the cloud. High-resolution spectra provid...

  7. Heterogeneous VM Replication: A New Approach to Intrusion Detection, Active Response and Recovery in Cloud Data Centers (United States)


    from the same execution history, and cost-effective active response by proactively setting up standby VM replicas: migration from a compromised VM... Computing requirements, such as scalable security monitoring, accountability, multi-abstraction isolation, security consolidation and elasticity. (a...Preserving Virtualization, 19th European Symposium on Research in Computer Security (ESORICS 2014). 07-SEP-14, . : , Ping Chen, Peng Liu, Bing Mao, Rui

  8. Body mass index, physical activity, and dietary behaviors among members of an urban community fitness center: a questionnaire survey

    Directory of Open Access Journals (Sweden)

    O'Neil Amy E


    Full Text Available Abstract Background Development of effective behavioral interventions to promote weight control and physical activity among diverse, underserved populations is a public health priority. Community focused wellness organizations, such as YMCAs, could provide a unique channel with which to reach such populations. This study assessed health behaviors and related characteristics of members of an urban YMCA facility. Methods We surveyed 135 randomly selected members of an urban YMCA facility in Massachusetts to examine self-reported (1 physical activity, (2 dietary behaviors, (3 body mass index, and (4 correlates of behavior change among short-term (i.e., one year or less and long-term (i.e., more than one year members. Chi-square tests were used to assess bivariate associations between variables, and multivariate linear regression models were fit to examine correlates of health behaviors and weight status. Results Eighty-nine percent of short-term and 94% of long-term members reported meeting current physical activity recommendations. Only 24% of short-term and 19% of long-term members met fruit and vegetable consumption recommendations, however, and more than half were overweight or obese. Length of membership was not significantly related to weight status, dietary behaviors, or physical activity. Most respondents were interested in changing health behaviors, in the preparation stage of change, and had high levels of self-efficacy to change behaviors. Short-term members had less education (p = 0.02, lower household incomes (p = 0.02, and were less likely to identify as white (p = 0.005 than long-term members. In multivariate models, females had lower BMI than males (p = 0.003 and reported less physical activity (p = 0.008. Physical activity was also inversely associated with age (p = 0.0004 and education (p = 0.02. Conclusion Rates of overweight/obesity and fruit and vegetable consumption suggested that there is a need for a weight control

  9. Luminescence centers and spectrum characteristics of a novel Eu{sup 2+}-activated hexa-aluminate CaZrBAl{sub 9}O{sub 18}

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Ruijin; Li, Hongjuan; Ma, Hailong; Wang, Caifeng; Wang, Huan [College of Science, Northwest A and F University, Yangling, Shaanxi (China)


    A new blue-emitting phosphor of Eu{sup 2+}-activated hexa-aluminate CaZrBAl{sub 9}O{sub 18} was synthesized by a conventional solid-state reaction method. The crystalline phase formation was confirmed by X-ray powder diffraction (XRD) measurements. The photoluminescence excitation and emission spectra, the luminescence decay curves and the time-resolved spectra of CaZrBAl{sub 9}O{sub 18}:Eu{sup 2+} were taken to investigate the luminescence characteristics. The dependence of CaZrBAl{sub 9}O{sub 18}:Eu{sup 2+} luminescence intensity on the Eu{sup 2+} doping concentrations was investigated. This phosphor can be efficiently excited by UV light and presents blue luminescence. There is one kind of Eu{sup 2+} luminescence center in the lattices, which was confirmed by the time-resolved luminescence spectra. The temperature-dependent luminescence intensity was measured and the activation energy (ΔE) for thermal quenching was reported. The phosphor shows high luminescence intensity and an excellent thermal stability on temperature quenching. Eu{sup 2+}-doped hexa-aluminate CaZrBAl{sub 9}O{sub 18} presents bright blue-emitting luminescence with high thermal quenching; only one Eu{sup 2+} center was confirmed in this hexa-aluminate lattices. (copyright 2014 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  10. Crystal structure of Helicobacter pylori neutrophil-activating protein with a di-nuclear ferroxidase center in a zinc or cadmium-bound form

    Energy Technology Data Exchange (ETDEWEB)

    Yokoyama, Hideshi, E-mail: [School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526 (Japan); Tsuruta, Osamu; Akao, Naoya; Fujii, Satoshi [School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526 (Japan)


    Highlights: Black-Right-Pointing-Pointer Structures of a metal-bound Helicobacter pylori neutrophil-activating protein were determined. Black-Right-Pointing-Pointer Two zinc ions were tetrahedrally coordinated by ferroxidase center (FOC) residues. Black-Right-Pointing-Pointer Two cadmium ions were coordinated in a trigonal-bipyramidal and octahedral manner. Black-Right-Pointing-Pointer The second metal ion was more weakly coordinated than the first at the FOC. Black-Right-Pointing-Pointer A zinc ion was found in one negatively-charged pore suitable as an ion path. -- Abstract: Helicobacter pylori neutrophil-activating protein (HP-NAP) is a Dps-like iron storage protein forming a dodecameric shell, and promotes adhesion of neutrophils to endothelial cells. The crystal structure of HP-NAP in a Zn{sup 2+}- or Cd{sup 2+}-bound form reveals the binding of two zinc or two cadmium ions and their bridged water molecule at the ferroxidase center (FOC). The two zinc ions are coordinated in a tetrahedral manner to the conserved residues among HP-NAP and Dps proteins. The two cadmium ions are coordinated in a trigonal-bipyramidal and distorted octahedral manner. In both structures, the second ion is more weakly coordinated than the first. Another zinc ion is found inside of the negatively-charged threefold-related pore, which is suitable for metal ions to pass through.

  11. 有源电力滤波器在某数据中心的应用%Application of Active Power Filter to Data Center

    Institute of Scientific and Technical Information of China (English)



    Burning out of capacitance compensation cabinet and trip failure of main breaker of low -voltage cabinet have happened for several times in the substation of a data center which has been put into operation. According to the field investigation, it is believed that the electric failures may be caused from excessive UPS configuration for the terminal computer, and harmonic pollution caused from using of a large number of LED lights. Effect of application of active power filter to the data center is introduced on the basis of field measurement of the harmonic data before and after setting of active power filter.%某已投入运行的数据中心变电所多次发生电容补偿柜烧坏及低压柜主断路器跳闸故障,作者现场考察认为故障可能是末端计算机所带UPS过多,以及大量使用LED灯导致的谐波污染而引起的电气故障。通过实测设置有源电力滤波器前后的谐波数据,说明有源电力滤波器在数据中心的应用效果。

  12. 整合设计在少年活动中心中应用%The Application of Integrated Design in the Youth Activity Center

    Institute of Scientific and Technical Information of China (English)

    徐青; 金丽燕


    本文根据德令哈青少年活动中心的使用特点,结合当地的气候条件和地形地势,坚持“以人为本”的设计理念。通过整合设计方法,打造出一个多样、活泼的青少年活动空间。%This article bases on the functional characteristics of Delingha youth activity center, combines with the local cli-mate and terrain and topography to adhere the"people-oriente-d"design concept. The author bases on the method of integrat-ed design to create a diverse and lively youth activity space.

  13. Affinity and activity of non-native quinones at the QB site of bacterial photosynthetic reaction centers (United States)

    Zhang, Xinyu; Gunner, M. R.


    Purple, photosynthetic reaction centers (RCs) from Rb. sphaeroides bacteria use UQ10 as primary (QA) and secondary (QB) electron acceptors. Many quinones reconstitute QA function, while few will act as QB. Nine quinones were tested for their ability to bind and reconstitute QA and QB function. Only ubiquinone (UQ) reconstitutes both QA and QB function in the same protein. The affinities of the non-native quinones for the QB site were determined by a competitive inhibition assay. The affinities of benzoquinones (BQ), napthoquinone (NQ) and 2-methyl-NQ for the QB site are 7±3 times weaker than for the QA site. However, di-ortho substituted NQs and anthraquinone bind tightly to the QA site (Kd ≤200 nM) and ≥1000 times more weakly to the QB site, perhaps setting a limit on the size of the site. With a low potential electron donor (2-methyl, 3-dimethylamino-1,4-Napthoquinone (Me-diMeAm-NQ)) at QA, QB reduction is 260 meV more favorable than with UQ as QA. Electron transfer from Me-diMeAm-NQ at the QA site to NQ at the QB site can be detected. In the QB site the NQ semiquinone is estimated to be ≈ 60–100 meV higher in energy than the UQ semiquinone, while in the QA site the semiquinone energy level is similar or lower with NQ than with UQ. Thus, the NQ semiquinone is more stable in the QA than QB site. In contrast, the native UQ semiquinone is ≈ 60 meV lower in energy in the QB than the QA site, stabilizing forward electron transfer from QA to QB. PMID:23715773

  14. Mutations affecting the high affinity ATPase center of gpA, the large subunit of bacteriophage lambda terminase, inactivate the endonuclease activity of terminase. (United States)

    Hwang, Y; Feiss, M


    Phage lambda terminase carries out the cos cleavage reaction that generates mature chromosomes from immature concatemeric DNA. The ATP-stimulated endonuclease activity of terminase is located in gpA, the large terminase subunit. There is a high affinity ATPase center in gpA, and a match to the conserved P-loop of known ATPases is found starting near residue 490. Changing the conserved P-loop lysine at residue 497 of gpA affects the high affinity ATPase activity of terminase. In the present work, mutations causing the gpA changes K497A and K497D were found to be lethal, and phages carrying these mutations were defective in cos cleavage, in vivo. Purified K497A and K497D enzymes cleaved cos in vitro at rates reduced from the wild-type rate by factors of 1000 and 2000, respectively. The strong defects in cos cleavage are sufficient to explain the lethality of the K497A and K497D defects. In in vitro packaging studies using mature (cleaved) phage DNA, the K497A enzyme was indistinguishable from the wild-type enzyme, and the K497D enzyme showed a mild packaging defect under limiting terminase conditions. In a purified DNA packaging system, the wild-type and K497D enzymes showed similar packaging activities that were stimulated to half-maximal levels at about 3 microM ATP, indicating that the K497D change does not affect DNA translocation. In sum, the work indicates that the high affinity ATPase center of gpA is involved in stimulation of the endonuclease activity of terminase.

  15. Research activity by National Center of Archaeological studies of Institute of History of Tatarstan Academy of Sciences in 2013

    Directory of Open Access Journals (Sweden)

    Sitdikov Ayrat G.


    Full Text Available The work of the National Center for Archaeological Studies named after A.Sh. Khalikov with the Institute of History named after Sh Mardjani of the Academy of Sciences of the Republic of Tatarstan (NCAS in 2013 was conducted within three Departments: prehistoric and medieval archaeology, conservation studies, and a bioarchaeological laboratory. The basic problems were: “Archaeology of the ancient population of the Volga-Kama: the formation and interaction of cultures”; “Medieval Turkic-Tatar civilization: the emergence, development, interaction with the peoples of Eurasia”; “Anthropology and genetics of the ancient population of the Middle Volga region”. Within the project on “Geographic information systems of Tatarstan archaeological heritage”, preparatory works for monitoring of the condition of cultural heritage objects located in the Kuibyshev and Nizhnekamsk reservoirs zones of influence were conducted. Archaeological fieldwork was conducted in the framework of the Primitive, Early Bulgar, Kazan, Bulgar, Lower Volga, Sviyazhsk archaeological expeditions and Preservation and salvation expedition in the area of Nizhnekamsk and Kuibyshev reservoirs. Beyond the Republic of Tatarstan, exploratory research was conducted in the territory of the Chuvash and Mordovian republics, Ulyanovsk and Samara Oblasts. The study of monuments in the Lower Volga region continued in collaboration with colleagues from the Astrakhan Oblast and the Republic of Mari El. Joint international archaeological research was carried out in the territory of the Republic of Bulgaria and Ukraine. 5 conferences were organized, including 4 international ones. The NCAS staff participated in 16 conferences, including 11 international ones. 2 Doctor habilitatus and 3 Doctor’s theses were defended. 5 collections of articles and theses, and 4 issues of the “Privolzhskaya arkheologiya” (Volga region archaeology were published. The NCAS staff prepared 216

  16. A step towards realizing a pan-European Climate Service - Activities of the Climate Service Center in the ECLISE project (United States)

    Weber, B.


    The overall objective of the EU funded project ECLISE (Enabling Climate Information Service for Europe) is to take the first step towards the realisation of a European Climate Service. The approach of this pan-European effort is to conduct 26 case studies in which researchers closely cooperate with users of climate information to develop and demonstrate local climate services to support climate adaption policies. ECLISE focuses on climate-vulnerable regions in Europe, and analyzes four sectoral levels: cities, water resources, coastal defence and energy production. The ECLISE approach covers all elements of flow of information including climate modelling, impact modelling and implementation of simulations into the decision making process on adaptation measures development. The Climate Service Center Germany (CSC) is one of 12 project partners and leads the work package integration and synthesis of project results. CSC contributes to the maintenance of dialogue between researchers and users and conducts climate simulation. One main task of CSC in ECLISE is to provide an outline and proof of concept for a pan-European Climate Service as a key outcome of the project. To reach this objective the first step is to provide an inventory of existing Climate Service initiatives around the globe. The ECLISE case study results will be analysed to investigate the functionality of local Climate Services within these demonstrations. In cooperation with other modelling groups CSC conducts climate simulations for whole Europe with a spatial resolution of 10 Km and for climate-vulnerable regions in particular with high spatial resolution (2-4 Km). These results will be implemented for further local impact and adaptation studies which will be done in close cooperation with local decision makers. The users of climate information in ECLISE are representatives from local and regional authorities, municipalities and decision makers from enterprises. In 2012 a broader set of European

  17. Overview of NASA Lewis Research Center free-piston Stirling engine technology activities applicable to space power systems (United States)

    Slaby, Jack G.


    A brief overview is presented of the development and technological activities of the free-piston Stirling engine. The engine started as a small scale fractional horsepower engine which demonstrated basic engine operating principles and the advantages of being hermetically sealed, highly efficient, and simple. It eventually developed into the free piston Stirling engine driven heat pump, and then into the SP-100 Space Reactor Power Program from which came the Space Power Demonstrator Engine (SPDE). The SPDE successfully operated for over 300 hr and delivered 20 kW of PV power to an alternator plunger. The SPDE demonstrated that a dynamic power conversion system can, with proper design, be balanced; and the engine performed well with externally pumped hydrostatic gas bearings.

  18. Hampshire College Center for Science Education. Final Report on Activities Supported by the Department of Energy Grant No. DE-FG02-06ER64256

    Energy Technology Data Exchange (ETDEWEB)

    Stillings, Neil; Wenk, Laura


    Hampshire College's Center for Science Education (Center) focuses on teacher professional development, curriculum development, and student enrichment programs. The Center also maintains research programs on teacher change, student learning and instructional effectiveness. The Center's work promotes learning that persists over time and transfers to new situations in and out of school. The projects develop the implications of the increasing agreement among teachers and researchers that effective learning involves active concept mastery and consistent practice with inquiry and critical thinking. The Center's objective is to help strengthen the pipeline of U.S. students pursuing postsecondary study in STEM fields. The Center achieves this by fostering an educational environment in which science is taught as an active, directly experienced endeavor across the K-16 continuum. Too often, young people are dissuaded from pursuing science because they do not see its relevance, instead experiencing it as dry, rote, technical. In contrast, when science is taught as a hands-on, inquiry-driven process, students are encouraged to ask questions grounded in their own curiosity and seek experimental solutions accordingly. In this way, they quickly discover both the profound relevance of science to their daily lives and its accessibility to them. Essentially, they learn to think and act like real scientists. The Center’s approach is multi-faceted: it includes direct inquiry-based science instruction to secondary and postsecondary students, educating the next generation of teachers, and providing new educational opportunities for teachers already working in the schools. Funding from the Department of Energy focused on the last population, enabling in-service teachers to explore and experience the pedagogy of inquiry-based science for themselves, and to take it back to their classrooms and students. The Center has demonstrated that the inquiry-based approach to science

  19. A longitudinal study of changes in asylum seekers ability regarding activities of daily living during their stay in the asylum center. (United States)

    Morville, Anne-Le; Amris, Kirstine; Eklund, Mona; Danneskiold-Samsøe, Bente; Erlandsson, Lena-Karin


    The aim was to assess change in activities of daily living (ADL) ability amongst asylum seekers and if there were any difference between tortured and non-torture following a 10 months post-arrival period, and if self-reported health and exposure to torture were factors related to change in ADL-ability. The study was a combined baseline, follow-up correlational study amongst individuals from Afghanistan, Iran and Syria, living in Danish asylum centers. Forty-three persons aged 20-50, were invited and participated in the baseline study. Twenty-two were still in asylum center at the follow-up and 17 of them participated. ADL-ability was measured using Assessment of Motor and Process Skills and questionnaires about exposure to torture, self-reported mental health and pain. ADL motor and process measures, well-being and self-rated health declined from baseline to follow-up. Measures of pain and depression increased. Exposure to physical torture and change in ADL motor (r = 0.525) measures were associated, as well as change in current pain and change in ADL process (r = 0.525) measures. Due to preponderance of torture survivors analysis of group difference was not applicable. Health care workers should be aware of ADL concerns and exposure to torture in this population to best address their needs within rehabilitation settings.

  20. Evaluation of 2,4-D removal via activated carbon from pomegranate husk/polymer composite hydrogel: Optimization of process parameters through face centered composite design

    Energy Technology Data Exchange (ETDEWEB)

    Taktak, Fulya; Ilbay, Zeynep [Usak Univ, Usak (Turkmenistan); Sahin, Selin [Istanbul University, Istanbul (Turkmenistan)


    A new type of polymer composite hydrogel was prepared by introducing activated carbons from pomegranate husk into poly ((2-dimethylamino) ethyl methacrylate) network. The removal of 2,4-dichlorophenoxyacetic acid (2,4-D) from aqueous solution was studied with respect to pH of the media, initial 2,4-D concentration and activated carbon content into the polymeric network. Face centered composite design (FCCD) through response surface methodology (RSM) was used for designing the experiments as well as for studying the effects of the process parameters. A quadratic model and a two factor interaction design model were developed for the removal of 2,4-D and adsorption capacity, respectively. The optimum pH of the pesticide solution, activated carbon content into the polymeric network and initial concentration of 2,4-D were found as 3, 2.5 wt% and 100mg/L. 63.245% and 68.805 (mg/g) for the removal of 2,4-D and adsorption capacity were obtained by using Simplex optimization method. Furthermore, the surface characteristics of the adsorbent prepared under optimized conditions were examined by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR).

  1. Self-assembly of cobalt-centered metal organic framework and multiwalled carbon nanotubes hybrids as a highly active and corrosion-resistant bifunctional oxygen catalyst (United States)

    Fang, Yiyun; Li, Xinzhe; Li, Feng; Lin, Xiaoqing; Tian, Min; Long, Xuefeng; An, Xingcai; Fu, Yan; Jin, Jun; Ma, Jiantai


    Metal organic frameworks (MOF) derived carbonaceous materials have emerged as promising bifunctional oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) catalysts for electrochemical energy conversion and storage. But previous attempts to overcome the poor electrical conductivity of MOFs hybrids involve a harsh high-template pyrolytic process to in situ form carbon, which suffer from extremely complex operation and inevitable carbon corrosion at high positive potentials when OER is operated. Herein, a self-assembly approach is presented to synthesize a non-precious metal-based, high active and strong durable Co-MOF@CNTs bifunctional catalyst for OER and ORR. CNTs not only improve the transportation of the electrons but also can sustain the harsh oxidative environment of OER without carbon corrosion. Meanwhile, the unique 3D hierarchical structure offers a large surface area and stable anchoring sites for active centers and CNTs, which enables the superior durability of hybrid. Moreover, a synergistic catalysis of Co(II), organic ligands and CNTs will enhance the bifunctional electrocatalytic performance. Impressively, the hybrid exhibits comparable OER and ORR catalytic activity to RuO2 and 20 wt% Pt/C catalysts and superior stability. This facile and versatile strategy to fabricating MOF-based hybrids may be extended to other electrode materials for fuel cell and water splitting applications.

  2. Enhancing mHealth Technology in the Patient-Centered Medical Home Environment to Activate Patients With Type 2 Diabetes: A Multisite Feasibility Study Protocol (United States)

    Shi, Lu; Williams, Joel E; Dye, Cheryl J; Chen, Liwei; Crawford, Paul; Shry, Eric A; Griffin, Sarah F; Jones, Karyn O; Sherrill, Windsor W; Truong, Khoa; Little, Jeanette R; Edwards, Karen W; Hing, Marie; Moss, Jennie B


    Background The potential of mHealth technologies in the care of patients with diabetes and other chronic conditions has captured the attention of clinicians and researchers. Efforts to date have incorporated a variety of tools and techniques, including Web-based portals, short message service (SMS) text messaging, remote collection of biometric data, electronic coaching, electronic-based health education, secure email communication between visits, and electronic collection of lifestyle and quality-of-life surveys. Each of these tools, used alone or in combination, have demonstrated varying degrees of effectiveness. Some of the more promising results have been demonstrated using regular collection of biometric devices, SMS text messaging, secure email communication with clinical teams, and regular reporting of quality-of-life variables. In this study, we seek to incorporate several of the most promising mHealth capabilities in a patient-centered medical home (PCMH) workflow. Objective We aim to address underlying technology needs and gaps related to the use of mHealth technology and the activation of patients living with type 2 diabetes. Stated differently, we enable supporting technologies while seeking to influence patient activation and self-care activities. Methods This is a multisite phased study, conducted within the US Military Health System, that includes a user-centered design phase and a PCMH-based feasibility trial. In phase 1, we will assess both patient and provider preferences regarding the enhancement of the enabling technology capabilities for type 2 diabetes chronic care management. Phase 2 research will be a single-blinded 12-month feasibility study that incorporates randomization principles. Phase 2 research will seek to improve patient activation and self-care activities through the use of the Mobile Health Care Environment with tailored behavioral messaging. The primary outcome measure is the Patient Activation Measure scores. Secondary outcome

  3. Centering research

    DEFF Research Database (Denmark)

    Katan, Lina Hauge; Baarts, Charlotte

    and collected 24 portfolios in which students reflect auto-ethnographically on their educational practices. Analyzing this qualitative material, we explore how researchers and students respectively read and write to develop and advance their thinking in those learning processes that the two groups fundamentally...... share as the common aim of both research and education. Despite some similarities, we find that how the two groups engage in and benefit from reading and writing diverges significantly. Thus we have even more reason to believe that centering practice-based teaching on these aspects of research is a good...

  4. Attivita del Centro di Linguistica Applicata nel campo della lingua e della cultura italiana all'estero (Activities of the Italian Center for Applied Linguistics concerning Italian Language and Culture Abroad). (United States)

    Boriosi Katerinov, Maria Clotilde


    Outlines the activities of a recently created section of the Italian Center for Applied Linguistics (CILA), dealing with "Teaching Italian Abroad." Describes these activities as encompassing four areas: research, teaching methodology, consultation, teachers' training and bibliographical information. Lists statistical surveys, research papers, and…

  5. Status of Activities on Rehabilitation Of Radioactively Contaminated Facilities and the Site of Russian Research Center ''Kurchatov Institute''

    Energy Technology Data Exchange (ETDEWEB)

    Volkov, V. G.; Ponomarev-Stepnoi, N. N.; Melkov, E. S; Ryazantsev, E. P.; Dikarev, V. S.; Gorodetsky, G. G.; Zverkov, Yu. A.; Kuznetsov, V. V.; Kuznetsova, T. I.


    This paper describes the program, the status, and the course of activities on rehabilitation of radioactively contaminated facilities and the territory of temporary radioactive waste (radwaste) disposal at the Russian Research Center ''Kurchatov Institute'' (RRC KI) in Moscow as performed in 2001-2002. The accumulation of significant amounts of radwaste at RRC KI territory is shown to be the inevitable result of Institute's activity performed in the days of former USSR nuclear weapons project and multiple initial nuclear power projects (performed from 1950's to early 1970's). A characterization of RRC KI temporary radwaste disposal site is given. Described is the system of radiation control and monitoring as implemented on this site. A potential hazard of adverse impacts on the environment and population of the nearby housing area is noted, which is due to possible spread of the radioactive plume by subsoil waters. A description of the concept and project of the RRC KI temporary radwaste disposal site is presented. Specific nature of the activities planned and performed stems from the nearness of housing area. This paper describes main stages of the planned activities for rehabilitation, their expected terms and sources of funding, as well as current status of the project advancement. Outlined are the problems faced in the performance and planning of works. The latter include: diagnostics of the concrete-grouted repositories, dust-suppression technologies, packaging of the fragmented ILW and HLW, soil clean-up, radioactive plume spread prevention, broad radiation monitoring of the work zone and environment in the performance of rehabilitation works. Noted is the intention of RRC KI to establish cooperation with foreign, first of all, the U.S. partners for the solution of problems mentioned above.

  6. Living Together in Space: The International Space Station Internal Active Thermal Control System Issues and Solutions-Sustaining Engineering Activities at the Marshall Space Flight Center From 1998 to 2005 (United States)

    Wieland, P. O.; Roman, M. C.; Miller, L.


    On board the International Space Station, heat generated by the crew and equipment is removed by the internal active thermal control system to maintain a comfortable working environment and prevent equipment overheating. Test facilities simulating the internal active thermal control system (IATCS) were constructed at the Marshall Space Flight Center as part of the sustaining engineering activities to address concerns related to operational issues, equipment capability, and reliability. A full-scale functional simulator of the Destiny lab module IATCS was constructed and activated prior to launch of Destiny in 2001. This facility simulates the flow and thermal characteristics of the flight system and has a similar control interface. A subscale simulator was built, and activated in 2000, with special attention to materials and proportions of wetted surfaces to address issues related to changes in fluid chemistry, material corrosion, and microbial activity. The flight issues that have arisen and the tests performed using the simulator facilities are discussed in detail. In addition, other test facilities at the MSFC have been used to perform specific tests related to IATCS issues. Future testing is discussed as well as potential modifications to the simulators to enhance their utility.

  7. Prediction of attendance at fitness center: a comparison between the theory of planned behavior, the social cognitive theory, and the physical activity maintenance theory. (United States)

    Jekauc, Darko; Völkle, Manuel; Wagner, Matthias O; Mess, Filip; Reiner, Miriam; Renner, Britta


    In the processes of physical activity (PA) maintenance specific predictors are effective, which differ from other stages of PA development. Recently, Physical Activity Maintenance Theory (PAMT) was specifically developed for prediction of PA maintenance. The aim of the present study was to evaluate the predictability of the future behavior by the PAMT and compare it with the Theory of Planned Behavior (TPB) and Social Cognitive Theory (SCT). Participation rate in a fitness center was observed for 101 college students (53 female) aged between 19 and 32 years (M = 23.6; SD = 2.9) over 20 weeks using a magnetic card. In order to predict the pattern of participation TPB, SCT and PAMT were used. A latent class zero-inflated Poisson growth curve analysis identified two participation patterns: regular attenders and intermittent exercisers. SCT showed the highest predictive power followed by PAMT and TPB. Impeding aspects as life stress and barriers were the strongest predictors suggesting that overcoming barriers might be an important aspect for working out on a regular basis. Self-efficacy, perceived behavioral control, and social support could also significantly differentiate between the participation patterns.

  8. In situ characterization of cofacial Co(IV) centers in Co4O4 cubane: Modeling the high-valent active site in oxygen-evolving catalysts. (United States)

    Brodsky, Casey N; Hadt, Ryan G; Hayes, Dugan; Reinhart, Benjamin J; Li, Nancy; Chen, Lin X; Nocera, Daniel G


    The Co4O4 cubane is a representative structural model of oxidic cobalt oxygen-evolving catalysts (Co-OECs). The Co-OECs are active when residing at two oxidation levels above an all-Co(III) resting state. This doubly oxidized Co(IV)2 state may be captured in a Co(III)2(IV)2 cubane. We demonstrate that the Co(III)2(IV)2 cubane may be electrochemically generated and the electronic properties of this unique high-valent state may be probed by in situ spectroscopy. Intervalence charge-transfer (IVCT) bands in the near-IR are observed for the Co(III)2(IV)2 cubane, and spectroscopic analysis together with electrochemical kinetics measurements reveal a larger reorganization energy and a smaller electron transfer rate constant for the doubly versus singly oxidized cubane. Spectroelectrochemical X-ray absorption data further reveal systematic spectral changes with successive oxidations from the cubane resting state. Electronic structure calculations correlated to experimental data suggest that this state is best represented as a localized, antiferromagnetically coupled Co(IV)2 dimer. The exchange coupling in the cofacial Co(IV)2 site allows for parallels to be drawn between the electronic structure of the Co4O4 cubane model system and the high-valent active site of the Co-OEC, with specific emphasis on the manifestation of a doubly oxidized Co(IV)2 center on O-O bond formation.

  9. Effects of electric stimulation of the hunger center in the lateral hypothalamus on slow electric activity and spike activity of fundal and antral stomach muscles in rabbits under conditions of hunger and satiation. (United States)

    Kromin, A A; Zenina, O Yu


    In chronic experiments on rabbits, the effect of electric stimulation of the hunger center in the lateral hypothalamus on myoelectric activity of the fundal and antral parts of the stomach was studied under conditions of hunger and satiation in the absence of food. Stimulation of the lateral hypothalamus in rabbits subjected to 24-h food deprivation and in previously fed rabbits produced incessant seeking behavior, which was followed by reorganization of the structure of temporal organization of slow wave electric activity of muscles of the stomach body and antrum specific for hungry and satiated animals. Increased hunger motivation during electric stimulation of the lateral hypothalamus manifested in the structure of temporal organization of slow wave electric activity of the stomach body and antrum muscles in rabbits subjected to 24-h food deprivation in the replacement of bimodal distribution of slow wave periods to a trimodal type typical of 2-day deprivation, while transition from satiation to hunger caused by electric stimulation of the lateral hypothalamus was associated with a shift from monomodal distributions of slow wave periods to a bimodal type typical of 24-h deprivation. Reorganization of the structure of temporal organization of slow wave electric activity of the stomach body and antrum muscles during electric stimulation of the lateral hypothalamus was determined by descending inhibitory influences of food motivational excitation on activity of the myogenic pacemaker of the lesser curvature of the stomach.

  10. "Infotonics Technology Center"

    Energy Technology Data Exchange (ETDEWEB)

    Fritzemeier, L. [Infotonics Technology Center Inc., Canandaigua, NY (United States); Boysel, M. B. [Infotonics Technology Center Inc., Canandaigua, NY (United States); Smith, D. R. [Infotonics Technology Center Inc., Canandaigua, NY (United States)


    During this grant period July 15, 2002 thru September 30, 2004, the Infotonics Technology Center developed the critical infrastructure and technical expertise necessary to accelerate the development of sensors, alternative lighting and power sources, and other specific subtopics of interest to Department of Energy. Infotonics fosters collaboration among industry, universities and government and operates as a national center of excellence to drive photonics and microsystems development and commercialization. A main goal of the Center is to establish a unique, world-class research and development facility. A state-of-the-art microsystems prototype and pilot fabrication facility was established to enable rapid commercialization of new products of particular interest to DOE. The Center has three primary areas of photonics and microsystems competency: device research and engineering, packaging and assembly, and prototype and pilot-scale fabrication. Center activities focused on next generation optical communication networks, advanced imaging and information sensors and systems, micro-fluidic systems, assembly and packaging technologies, and biochemical sensors. With targeted research programs guided by the wealth of expertise of Infotonics business and scientific staff, the fabrication and packaging facility supports and accelerates innovative technology development of special interest to DOE in support of its mission and strategic defense, energy, and science goals.

  11. Distributed H2 Supply for Fuel Cell Utility Vehicles Year 6 - Activity 3.5 - Development fo a National Center for Hydrogen Technology

    Energy Technology Data Exchange (ETDEWEB)

    Almlie, Jay


    The Energy & Environmental Research Center (EERC) has developed a high-pressure hydrogen production system that reforms a liquid organic feedstock and water at operating pressures up to 800 bar (~12,000 psig). The advantages of this system include the elimination of energy-intensive hydrogen compression, a smaller process footprint, and the elimination of gaseous or liquid hydrogen transport. This system could also potentially enable distributed hydrogen production from centralized coal. Processes have been investigated to gasify coal and then convert the syngas into alcohol or alkanes. These alcohols and alkanes could then be easily transported in bulk to distributed high-pressure water-reforming (HPWR)-based systems to deliver hydrogen economically. The intent of this activity was to utilize the EERC’s existing HPWR hydrogen production process, previously designed and constructed in a prior project phase, as a basis to improve operational and production performance of an existing demonstration unit. Parameters to be pursued included higher hydrogen delivery pressure, higher hydrogen production rates, and the ability to refill within a 5-minute time frame.

  12. Genetic background specific hypoxia resistance in rat is correlated with balanced activation of a cross-chromosomal genetic network centering on physiological homeostasis

    Directory of Open Access Journals (Sweden)

    Lei eMao


    Full Text Available Genetic background of an individual can drastically influence an organism’s response upon environmental stress and pathological stimulus. Previous studies in inbred rats showed that compared to Brown Norway (BN, Dahl salt-sensitive (SS rat exerts strong hypoxia susceptibility. However, despite extensive narrow-down approaches via the chromosome substitution methodology, this genome-based physiological predisposition could not be traced back to distinct quantitative trait loci. Upon the completion and public data availability of PhysGen SS-BN consomic rat platform, I employed systems biology approach attempting to further our understanding of the molecular basis of genetic background effect in light of hypoxia response. I analyzed the physiological screening data of 22 consomic rat strains under normoxia and two-weeks of hypoxia, and cross-compared them to the parental strains. The analyses showed that SS-9BN and SS-18BN represent the most hypoxia resistant CS strains with phenotype similar to BN, whereas SS-6BN and SS-YBN segregated to the direction of SS. A meta-analysis on the transcriptomic profiles of these consomic rat strains under hypoxia treatment showed that although polymorphisms on the substituted BN chromosomes could be directly involved in hypoxia resistance, this seems to be embedded in a more complex trans-chromosomal genetic regulatory network. Via information theory based modeling approach, this hypoxia-relevant core genetic network was reverse-engineered. Network analyses showed that the protective effects of BN chromosome 9 and 18 were reflected by a balanced activation of this core network centering on physiological homeostasis. Presumably, it is the system robustness constituted on such differential network activation that acts as hypoxia response modifier. Understanding of the intrinsic link between the individual genetic background and the network robustness will set a basis in the current scientific efforts toward

  13. Genetic Background Specific Hypoxia Resistance in Rat is Correlated with Balanced Activation of a Cross-Chromosomal Genetic Network Centering on Physiological Homeostasis. (United States)

    Mao, Lei


    Genetic background of an individual can drastically influence an organism's response upon environmental stress and pathological stimulus. Previous studies in inbred rats showed that compared to Brown Norway (BN), Dahl salt-sensitive (SS) rat exerts strong hypoxia susceptibility. However, despite extensive narrow-down approaches via the chromosome substitution methodology, this genome-based physiological predisposition could not be traced back to distinct quantitative trait loci. Upon the completion and public data availability of PhysGen SS-BN consomic (CS) rat platform, I employed systems biology approach attempting to further our understanding of the molecular basis of genetic background effect in light of hypoxia response. I analyzed the physiological screening data of 22 CS rat strains under normoxia and 2-weeks of hypoxia, and cross-compared them to the parental strains. The analyses showed that SS-9(BN) and SS-18(BN) represent the most hypoxia-resistant CS strains with phenotype similar to BN, whereas SS-6(BN) and SS-Y(BN) segregated to the direction of SS. A meta-analysis on the transcriptomic profiles of these CS rat strains under hypoxia treatment showed that although polymorphisms on the substituted BN chromosomes could be directly involved in hypoxia resistance, this seems to be embedded in a more complex trans-chromosomal genetic regulatory network. Via information theory based modeling approach, this hypoxia relevant core genetic network was reverse engineered. Network analyses showed that the protective effects of BN chromosome 9 and 18 were reflected by a balanced activation of this core network centering on physiological homeostasis. Presumably, it is the system robustness constituted on such differential network activation that acts as hypoxia response modifier. Understanding of the intrinsic link between the individual genetic background and the network robustness will set a basis in the current scientific efforts toward personalized medicine.

  14. Assessment of nutritional activities under integrated child development services at anganwadi centers of different districts of Gujarat from April 2012 to March 2015

    Directory of Open Access Journals (Sweden)

    Rajesh K Chudasama


    Full Text Available Background: The Integrated Child Development Service (ICDS program aims at enhancing survival and development of children from the vulnerable sections of the society. Aim: The present study was conducted to assess various nutritional activities at anganwadi centers (AWCs in different districts of Gujarat state. Settings and Design: AWCs, cross-sectional study. Materials and Methods: A total of 130 AWCs were selected including 95 from rural and 35 from urban area from April 2012 to March 2015 including 12 districts of Gujarat and union territory, Diu. Five AWCs were selected from one district randomly. Detailed information about various nutritional activities including growth monitoring, preschool education (PSE and nutrition and health education (NHED, coverage for supplementary nutrition (SN, type of food provided under SN, and its issues at AWCs was collected. Statistical Analysis: Percentages, proportions, Chi-square/Fischer's exact test. Results: Growth chart was available in 96.9% AWCs. The malnutrition was reported among 14.9% children. PSE received by all children was only in 14.6% AWCs. NHED meeting was conducted in 73.8% AWCs. High coverage of receiving SN among enrolled was reported in pregnant and lactating mothers (84.6% and adolescents (79.2%. SN was fully acceptable in 91.5% AWCs. Interruption in SN supply during last 6 months was reported in 55.4% AWCs. Conclusion: Regular workshops should be conducted for ICDS staff to sensitize them about the importance of and practices on PSE. Interruption in supply of SN should be corrected by regular and adequate provision of SN foods to the beneficiaries.

  15. Exploring clouds, weather, climate, and modeling using bilingual content and activities from the Windows to the Universe program and the Center for Multiscale Modeling of Atmospheric Processes (United States)

    Foster, S. Q.; Johnson, R. M.; Randall, D.; Denning, S.; Russell, R.; Gardiner, L.; Hatheway, B.; Genyuk, J.; Bergman, J.


    The need for improving the representation of cloud processes in climate models has been one of the most important limitations of the reliability of climate-change simulations. Now in its third year, the National Science Foundation-funded Center for Multi-scale Modeling of Atmospheric Processes (CMMAP) at Colorado State University is addressing this problem through a revolutionary new approach to representing cloud processes on their native scales, including the cloud-scale interaction processes that are active in cloud systems. CMMAP has set ambitious education and human-resource goals to share basic information about the atmosphere, clouds, weather, climate, and modeling with diverse K-12 and public audiences through its affiliation with the Windows to the Universe (W2U) program at University Corporation for Atmospheric Research (UCAR). W2U web pages are written at three levels in English and Spanish. This information targets learners at all levels, educators, and families who seek to understand and share resources and information about the nature of weather and the climate system, and career role models from related research fields. This resource can also be helpful to educators who are building bridges in the classroom between the sciences, the arts, and literacy. Visitors to the W2U's CMMAP web portal can access a beautiful new clouds image gallery; information about each cloud type and the atmospheric processes that produce them; a Clouds in Art interactive; collections of weather-themed poetry, art, and myths; links to games and puzzles for children; and extensive classroom- ready resources and activities for K-12 teachers. Biographies of CMMAP scientists and graduate students are featured. Basic science concepts important to understanding the atmosphere, such as condensation, atmosphere pressure, lapse rate, and more have been developed, as well as 'microworlds' that enable students to interact with experimental tools while building fundamental knowledge

  16. Laboratory-confirmed HIV and sexually transmitted infection seropositivity and risk behavior among sexually active transgender patients at an adolescent and young adult urban community health center. (United States)

    Reisner, Sari L; Vetters, Ralph; White, Jaclyn M; Cohen, Elijah L; LeClerc, M; Zaslow, Shayne; Wolfrum, Sarah; Mimiaga, Matthew J


    The sexual health of transgender adolescents and young adults who present for health care in urban community health centers is understudied. A retrospective review of electronic health record (EHR) data was conducted from 180 transgender patients aged 12-29 years seen for one or more health-care visits between 2001 and 2010 at an urban community health center serving youth in Boston, MA. Analyses were restricted to 145 sexually active transgender youth (87.3% of the sample). Laboratory-confirmed HIV and sexually transmitted infections (STIs) seroprevalence, demographics, sexual risk behavior, and structural and psychosocial risk indicators were extracted from the EHR. Analyses were descriptively focused for HIV and STIs. Stratified multivariable logistic regression models were fit for male-to-female (MTF) and female-to-male (FTM) patients separately to examine factors associated with any unprotected anal and/or vaginal sex (UAVS). The mean age was 20.0 (SD=2.9); 21.7% people of color, 46.9% white (non-Hispanic), 21.4% race/ethnicity unknown; 43.4% MTF, and 56.6% FTM; and 68.3% were on cross-sex hormones. Prevalence of STIs: 4.8% HIV, 2.8% herpes simplex virus, 2.8% syphilis, 2.1% chlamydia, 2.1% gonorrhea, 2.8% hepatitis C, 1.4% human papilloma virus. Only gonorrhea prevalence significantly differed by gender identity (MTF 2.1% vs. 0.0% FTM; p=0.046). Nearly half (47.6%) of the sample engaged in UAVS (52.4% MTF, 43.9% FTM, p=0.311). FTM more frequently had a primary sex partner compared to MTF (48.8% vs. 25.4%; p=0.004); MTF more frequently had a casual sex partner than FTM (69.8% vs. 42.7% p=0.001). In multivariable models, MTF youth who were younger in age, white non-Hispanic, and reported a primary sex partner had increased odds of UAVS; whereas, FTM youth reporting a casual sex partner and current alcohol use had increased odds of UAVS (all psexual risk differ for MTF and FTM youth. Partner type appears pivotal to understanding sexual risk in transgender

  17. Italy INAF Analysis Center Report (United States)

    Negusini, M.; Sarti, P.


    This report summarizes the activity of the Italian INAF VLBI Analysis Center. Our Analysis Center is located in Bologna, Italy and belongs to the Institute of Radioastronomy, which is part of the National Institute of Astrophysics. IRA runs the observatories of Medicina and Noto, where two 32-m VLBI AZ-EL telescopes are situated. This report contains the AC's VLBI data analysis activities and shortly outlines the investigations into the co-locations of space geodetic instruments.

  18. Mississippi Technology Transfer Center (United States)


    The Mississippi Technology Transfer Center at the John C. Stennis Space Center in Hancock County, Miss., was officially dedicated in 1987. The center is home to several state agencies as well as the Center For Higher Learning.

  19. Program ACTIVE II: Design and Methods for a Multi-Center Community-Based Depression Treatment for Rural and Urban Adults with Type 2 Diabetes (United States)

    de Groot, Mary; Shubrook, Jay; Schwartz, Frank; Hornsby, W. Guyton; Pillay, Yegan; Saha, Chandan


    Objective Depression affects one in four adults with type 2 diabetes (T2DM) and is associated with worsened diabetes complications, increased health care costs and early mortality. Rural and low-income urban areas, including the Appalachian region, represent an epicenter of the T2DM epidemic. Program ACTIVE II is a comparative effectiveness treatment trial designed to test whether a combination of cognitive behavioral therapy (CBT) and community-based exercise (EXER) will offer greater improvements in diabetes and depression outcomes compared to individual treatment approaches and usual care (UC). The secondary aims are to assess changes in cardiovascular risk factors across groups and to conduct a cost-effectiveness analysis of predicted incidence of cardiovascular complications across groups. Methods The study is a 2-by-2 factorial randomized controlled trial consisting of 4 treatment groups: CBT alone, EXER alone, combination of CBT and EXER, and UC. Adults with T2DM for > 1 year and who meet DSM-IVTR criteria for Major Depressive Disorder (MDD) are eligible to participate at two rural Appalachian sites (southeastern Ohio and West Virginia) and one urban site (Indianapolis). This type II behavioral translation study uses a community-engaged research (CEnR) approach by incorporating community fitness centers and mental health practices as interventionists. Conclusions This is the first study to evaluate the comparative effectiveness of combined CBT and exercise in the treatment of depression using community-based intervention delivery. This approach may serve as a national model for expanding depression treatment for patients with T2DM. PMID:27500279

  20. State Institution "National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine" - research activities and scientific advance in 2013. (United States)

    Bazyka, D; Sushko, V; Chumak, A; Buzunov, V; Talko, V; Yanovych, L


    Research activities and scientific advance achieved in 2013 at the State Institution "National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine" (NRCRM) concerning medical problems of the Chornobyl disaster, radiation medicine, radiobiology, radiation hygiene and epidemiology in collaboration with the WHO network of medical preparedness and assistance in radiation accidents are outlined in the annual report. Key points include the research results of XRCC1 and XPD gene polymorphism in thyroid cancer patients, CD38 gene GG genotype as a risk factor for chronic lymphocytic leukemia, frequency of 185delAG and 5382insC mutations in BRCA1 gene in women with breast cancer, cognitive function and TERF1, TERF2, TERT gene expression both with telomere length in human under the low dose radiation exposure. The "source-scattering/shielding structures- man" models for calculation of partial dose values to the eye lens and new methods for radiation risk assessment were developed and adapted. Radiation risks of leukemia including chronic lymphocytic leukemia in the cohort of liquidators were published according to the "case-control" study results after 20 years of survey. Increase of non-tumor morbidity in liquidators during the 1988-2011 with the maximum level 12-21 years upon irradiation was found. Incidence in evacuees appeared being of two-peak pattern i.e. in the first years after the accident and 12 years later. Experimental studies have concerned the impact of radio-modifiers on cellular systems, reproductive function in the population, features of the child nutrition in radiation contamination area were studied. Report also shows the results of scientific and organizational, medical and preventive work, staff training, and implementation of innovations. The NRCRM Annual Report was approved at the Scientific Council meeting of NAMS on March 3, 2014.

  1. Quality Assurance Plan for Field Activities at the Natural and Accelerated Bioremediation Research (NABIR) Field Research Center (FRC), Oak Ridge, Tennessee

    Energy Technology Data Exchange (ETDEWEB)

    Brandt, C.C.


    The Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) has established a Natural and Accelerated Bioremediation Research (NABIR) program Field Research Center (FRC) for the U.S. Department of Energy (DOE) Office of Biological and Environmental Research. The FRC is located in Bear Creek Valley within the Y-12 Plant area of responsibility on DOE's Oak Ridge Reservation in Tennessee. The NABIR program is a long-term effort designed to increase the understanding of fundamental biogeochemical processes that would allow the use of bioremediation approaches for cleaning up DOE's contaminated legacy waste sites. The FRC provides a site for investigators in the NABIR program to conduct research and obtain samples related to in situ bioremediation. The FRC is integrated with existing and future laboratory and field research and provides a means of examining the biogeochemical processes that influence bioremediation under controlled small-scale field conditions. This Quality Assurance Plan (QAP) documents the quality assurance protocols for field and laboratory activities performed by the FRC staff. It supplements the requirements in the ORNL Nuclear Quality Assurance Program and the ESD Quality Assurance Program. The QAP addresses the requirements in Title 10 CFR, Part 830 Subpart A, ''Quality Assurance Requirements'', using a graded approach appropriate for Research and Development projects based on guidance from ''Implementation Guide for Quality Assurance Programs for Basic and Applied Research'' (DOE-ER-STD-6001-92). It also supports the NABIR FRC Management Plan (Watson and Quarles 2000a) which outlines the overall procedures, roles and responsibilities for conducting research at the FRC. The QAP summarizes the organization, work activities, and qualify assurance and quality control protocols that will be used to generate scientifically defensible data at the FRC. The QAP pertains to field

  2. Anticipatory control of center of mass and joint stability during voluntary arm movement from a standing posture: interplay between active and passive control. (United States)

    Patla, Aftab E; Ishac, Milad G; Winter, David A


    Anticipatory control of upright posture is the focus of this study that combines experimental and modeling work. Individuals were asked to raise or lower their arms from two initial postures such that the final posture of the arm was at 90 degrees with respect to the body. Holding different weights in the hand varied the magnitude of perturbation to postural stability generated by the arm movement. Whole body kinematics and ground reaction forces were measured. Inverse dynamic analysis was used to determine the internal joint moments at the shoulder, hip, knee and ankle, and reaction forces at the shoulder. Center of mass (COM) of the arm, posture (rest of the body without the arms) and whole body (net COM) were also determined. Changes in joint moment at the hip, knee and ankle revealed a significant effect of the direction of movement. The polarities of the joint moment response were appropriate for joint stabilization. Net COM change showed a systematic effect of the direction of movement even though the arm COM was displaced by the same amount and in the same direction for both arm raising and lowering conditions. In order to determine the effects of the passive forces and moments on the posture COM, the body was modeled as an inverted pendulum. The model was customized for each participant; the relevant model parameters were estimated from data obtained from each trial. The ankle joint stiffness and viscosity were adjusted to ensure postural equilibrium prior to arm movement. Joint reactive forces and moments generated by the arm movements were applied at the shoulder level of this inverted pendulum; these were the only inputs and no active control was included. The posture COM profile from the model simulation was calculated. Results show that simulated posture COM profile and measured posture COM profile are identical for about 200 ms following the onset of arm movement and then they deviate. Therefore, the initial control of COM is passive in nature and the

  3. Non-tuberculous mycobacteria I: one year clinical isolates identification in Tertiary Hospital Aids Reference Center, Rio de Janeiro, Brazil, in pre highly active antiretroviral therapy era

    Directory of Open Access Journals (Sweden)

    Ferreira Rosa Maria Carvalho


    Full Text Available The aim of this study was to determine the prevalence of non-tuberculous mycobacteria (NTM isolates at University Hospital, Reference Center for Aids in Rio de Janeiro, Brazil, during one year. We used standard biochemical tests for species identification and IS1245 PCR amplification was applied as a Mycobacterium avium specific identification marker. Four hundred and four specimens from 233 patients yielded acid-fast bacilli growth. M. tuberculosis was identified in 85% of the patients and NTM in 15%. NTM disseminated infection was a common event correlated with human immunodeficiency virus (HIV infected patients and only in HIV negative patients the source of NTM was non sterile site. M. avium complex (MAC was biochemically identified in 57.8% (49/83 of NTM isolates, most of them from sterile sites (75.5%, and in 94% (46/49 the IS 1245 marker specific for M. avium was present. Twenty NTM strains showed a MAC biochemical pattern with the exception of a urease-positive (99% of MAC are urease-negative, however IS1245 was detected in 96% of the strains leading to their identification as M. avium. In this group differences in NTM source was not significant. The second most frequently isolated NTM was identified as M. scrofulaceum (7.2%, followed by M. terrae (3.6%, M. gordonae (2.4%, M. chelonae (1.2%, M. fortuitum (1.2% and one strain which could not be identified. All were IS1245 negative except for one strain identified as M. scrofulaceum. It is interesting to note that non-sterile sites were the major source of these isolates (92.8%. Our finding indicated that M. avium is still the major atypical species among in the MAC isolates recovered from Brazilian Aids patients without highty active antiretroviral therapy schema. Some discrepancies were seen between the identification methods and further investigations must be done to better characterize NTM isolates using other phenotypic and genotypic methods.

  4. Sustainable Biofuels Development Center

    Energy Technology Data Exchange (ETDEWEB)

    Reardon, Kenneth F. [Colorado State Univ., Fort Collins, CO (United States)


    The mission of the Sustainable Bioenergy Development Center (SBDC) is to enhance the capability of America’s bioenergy industry to produce transportation fuels and chemical feedstocks on a large scale, with significant energy yields, at competitive cost, through sustainable production techniques. Research within the SBDC is organized in five areas: (1) Development of Sustainable Crops and Agricultural Strategies, (2) Improvement of Biomass Processing Technologies, (3) Biofuel Characterization and Engine Adaptation, (4) Production of Byproducts for Sustainable Biorefining, and (5) Sustainability Assessment, including evaluation of the ecosystem/climate change implication of center research and evaluation of the policy implications of widespread production and utilization of bioenergy. The overall goal of this project is to develop new sustainable bioenergy-related technologies. To achieve that goal, three specific activities were supported with DOE funds: bioenergy-related research initiation projects, bioenergy research and education via support of undergraduate and graduate students, and Research Support Activities (equipment purchases, travel to attend bioenergy conferences, and seminars). Numerous research findings in diverse fields related to bioenergy were produced from these activities and are summarized in this report.

  5. Transplant Center Search Form (United States)

    ... Share Your Story Give Us Feedback - A + A Transplant Center Search Form Welcome to the Blood & Marrow ... transplant centers for patients with a particular disease. Transplant Center login Username: * Password: * Request new password Join ...

  6. Children's cancer centers (United States)

    Pediatric cancer center; Pediatric oncology center; Comprehensive cancer center ... Treating childhood cancer is not the same as treating adult cancer. The cancers are different. So are the treatments and the ...

  7. Southern California Particle Center (United States)

    Federal Laboratory Consortium — At the Southern California Particle Center, center researchers will investigate the underlying mechanisms that produce the health effects associated with exposure to...

  8. Womens Business Center (United States)

    Small Business Administration — Women's Business Centers (WBCs) represent a national network of nearly 100 educational centers throughout the United States and its territories, which are designed...

  9. Sexually Active Teenagers Are More Likely To Be Depressed and To Attempt Suicide. A Report of the Heritage Center for Data Analysis. (United States)

    Rector, Robert E.; Johnson, Kirk A.; Noyes, Lauren R.

    Although teen sexual activity has declined in recent years, the overall rate is still high. The problems associated with teen sexual activity are well known. Less widely known are the psychological and emotional problems associated with this activity. The present study examines the linkage between teenage sexual activity and emotional health. The…

  10. Flash kinetics in liquefied noble gases: Studies of alkane activation and ligand dynamics at rhodium carbonyl centers, and a search for xenon-carbene adducts

    Energy Technology Data Exchange (ETDEWEB)

    Yeston, Jake Simon [Univ. of California, Berkeley, CA (United States)


    A general introduction is given to place the subsequent chapters in context for the nonspecialist. Results are presented from a low temperature infrared (IR) flash kinetic study of C-H bond activation via photoinduced reaction of Cp*Rh(CO)2 (1) with linear and cyclic alkanes in liquid krypton and liquid xenon solution. No reaction was observed with methane; for all other hydrocarbons studied, the rate law supports fragmentation of the overall reaction into an alkane binding step followed by an oxidative addition step. For the binding step, larger alkanes within each series (linear and cyclic) interact more strongly than smaller alkanes with the Rh center. The second step, oxidative addition of the C-H bond across Rh, exhibits very little variance in the series of linear alkanes, while in the cyclic series the rate decreases with increasing alkane size. Results are presented from an IR flash kinetic study of the photoinduced chemistry of Tp*Rh(CO)2 (5; Tp* = hydridotris(3,5-dimethylpyrazolyl)borato) in liquid xenon solution at –50 °C. IR spectra of the solution taken 2 μs after 308 nm photolysis exhibit two transient bands at 1972-1980 cm-1 and 1992-2000 cm-1, respectively. These bands were assigned to (η3-Tp*)Rh(CO)•Xe and (η2-Tp*)Rh(CO)•Xe solvates on the basis of companion studies using Bp*Rh(CO)2 (9; Bp* = dihydridobis(3,5-dimethyl pyrazolyl)borato). Preliminary kinetic data for reaction of 5 with cyclohexane in xenon solution indicate that both transient bands still appear and that their rates of decay correlate with formation of the product Tp*Rh(CO)(C6H11)(H). The preparation and reactivity of the new complex Bp*Rh(CO)(pyridine) (11) are described. The complex reacts with CH3I to yield the novel Rh carbene hydride complex HB(Me2pz)2Rh(H)(I)(C5H5N)(C(O)Me) (12), resulting from formal addition of CH


    Directory of Open Access Journals (Sweden)

    Rosca Remus Dorel


    The ideas presented in this paper are to represent a part of a good practice guide on implementing student-centered education within a high educational institution. The concern for this concept is determined by the current context of the high educational system in Romania characterized by: the intensification of the competitive environment; increasing employers’ demands; increasing high school graduates and students’ demands towards the quality offered by a high educational institution; the performance indicators used by ARACIS in the evaluation of the universities, a very relevant example being the graduates’ professional route in the labour field. We are convinced that the ideas presented in this paper are important to the decision factors from the academic environment, factors that should initiate and facilitate the implementation of the student- centered education concept.

  12. Caring for people with dementia in residential aged care: successes with a composite person-centered care model featuring Montessori-based activities. (United States)

    Roberts, Gail; Morley, Catherine; Walters, Wendy; Malta, Sue; Doyle, Colleen


    Person-centered models of dementia care commonly merge aspects of existing models with additional influences from published and unpublished evidence and existing government policy. This study reports on the development and evaluation of one such composite model of person-centered dementia care, the ABLE model. The model was based on building the capacity and ability of residents living with dementia, using environmental changes, staff education and organizational and community engagement. Montessori principles were also used. The evaluation of the model employed mixed methods. Significant behavior changes were evident among residents of the dementia care Unit after the model was introduced, as were reductions in anti-psychotic and sedative medication. Staff reported increased knowledge about meeting the needs of people with dementia, and experienced organizational culture change that supported the ABLE model of care. Families were very satisfied with the changes.

  13. Enhancement of laccase activity through the construction and breakdown of a hydrogen bond at the type I copper center in Escherichia coli CueO and the deletion mutant Δα5-7 CueO. (United States)

    Kataoka, Kunishige; Hirota, Shun; Maeda, Yasuo; Kogi, Hiroki; Shinohara, Naoya; Sekimoto, Madoka; Sakurai, Takeshi


    CueO is a multicopper oxidase involved in a copper efflux system of Escherichia coli and has high cuprous oxidase activity but little or no oxidizing activity toward various organic substances. However, its activity toward oxidization of organic substrates was found to be considerably increased by the removal of the methionine-rich helical segment that covers the substrate-binding site (Δα5-7 CueO) [Kataoka, K., et al. (2007) J. Mol. Biol. 373, 141]. In the study presented here, mutations at Pro444 to construct a second NH-S hydrogen bond between the backbone amide and coordinating Cys500 thiolate of the type I copper are shown to result in positive shifts in the redox potential of this copper center and enhanced oxidase activity in CueO. Analogous enhancement of the activity of Δα5-7 CueO has been identified only in the Pro444Gly mutant because Pro444 mutants limit the incorporation of copper ions into the trinuclear copper center. The activities of both CueO and Δα5-7 CueO were also enhanced by mutations to break down the hydrogen bond between the imidazole group of His443 that is coordinated to the type I copper and the β-carboxy group of Asp439 that is located in the outer sphere of the type I copper center. A synergetic effect of the positive shift in the redox potential of the type I copper center and the increase in enzyme activity has been achieved by the double mutation of Pro444 and Asp439 of CueO. Absorption, circular dichroism, and resonance Raman spectra indicate that the characteristics of the Cu(II)-S(Cys) bond were only minimally perturbed by mutations involving formation or disruption of a hydrogen bond from the coordinating groups to the type I copper. This study provides widely applicable strategies for tuning the activities of multicopper oxidases.

  14. Center for Beam Physics, 1993

    Energy Technology Data Exchange (ETDEWEB)


    The Center for Beam Physics is a multi-disciplinary research and development unit in the Accelerator and Fusion Research Division at Lawrence Berkeley Laboratory. At the heart of the Center`s mission is the fundamental quest for mechanisms of acceleration, radiation and focusing of energy. Dedicated to exploring the frontiers of the physics of (and with) particle and photon beams, its primary mission is to promote the science and technology of the production, manipulation, storage and control systems of charged particles and photons. The Center serves this mission via conceptual studies, theoretical and experimental research, design and development, institutional project involvement, external collaborations, association with industry and technology transfer. This roster provides a glimpse at the scientists, engineers, technical support, students, and administrative staff that make up this team and a flavor of their multifaceted activities during 1993.

  15. Student Success Center Toolkit (United States)

    Jobs For the Future, 2014


    "Student Success Center Toolkit" is a compilation of materials organized to assist Student Success Center directors as they staff, launch, operate, and sustain Centers. The toolkit features materials created and used by existing Centers, such as staffing and budgeting templates, launch materials, sample meeting agendas, and fundraising…

  16. Taiyuan Satellite Launch Center

    Institute of Scientific and Technical Information of China (English)



    There are three major space launch bases in China, the Jiuquan Satellite Launch Center,the Taiyuan Satellite Launch Center and the Xichang Satellite Launch Center. All the three launch centers are located in sparsely populated areas where the terrain is even and the field of vision is broad. Security, transport conditions and the influence of the axial rotation

  17. Regional Warning Center Sweden (United States)

    Lundstedt, Henrik

    RWC-Sweden is operated by the Lund division of the Swedish Institute of Space Physics located at IDEON, a Science Research Technology Park. The Institute of Technology of Lund and Lund University are just adjacent to IDEON. This creates a lot of synergy effects. Copenhagen, with the Danish National Space Center DNSC), and Atmosphere Space Research Division of Danish Meteorological Institute (DMI), is 45 min away via the bridge. The new LOIS Space Centre is located two hours away by car, north of Lund and just outside V¨xj¨. The IRF Lund a o division is aiming at becoming a "Solar and Space Weather Center". We focus on solar magnetic activity, its influence on climate and on space weather effects such the effect of geomagnetically induced currents (GIC). Basic research: A PostDoc position on "Solar Magnetic Activity: Topology and Predictions has recently been created. Research is carried on to improve predictions of solar magnetic activity. Preparations for using upcoming SDO vector magnetic fields are ongoing. Predictions: RWC-Sweden offers real-time forecasts of space weather and space weather effects based on neural networks. We participated in the NASA/NOAA Cycle 24 Prediction Panel. We have also participated in several ESA/EU solar-climate projects New observation facilities: Distributed, wide-area radio facility (LOIS) for solar (and other space physics) observations and a guest prof: Radio facility about 200 km distant, outside V¨xj¨ (Sm˚ a o aland), in Ronneby (Blekinge) and Lund (Sk˚ ane) is planned to be used for tracking of CMEs and basic solar physics studies of the corona. The LOIS station outside V¨xj¨ has a o been up and running for the past three years. Bo Thidé has joined the Lund division e as a guest prof. A new magnetometer at Risinge LOIS station has been installed an calibrated and expected to be operational in March, 2008.

  18. Enthalpy/entropy driven activation of the first interquinone electron transfer in bacterial photosynthetic reaction centers embedded in vesicles of physiologically important phospholipids. (United States)

    Milano, Francesco; Dorogi, Márta; Szebényi, Kornélia; Nagy, László; Maróti, Péter; Váró, György; Giotta, Livia; Agostiano, Angela; Trotta, Massimo


    The thermodynamics and kinetics of light-induced electron transfer in bacterial photosynthetic RCs are sensitive to physiologically important lipids (phosphatidylcholine, cardiolipin and phosphatidylglycerol) in the environment. The analysis of the temperature-dependence of the rate of the P(+)Q(A)(-)Q(B)-->P(+)Q(A)Q(B)(-) interquinone electron transfer revealed high enthalpy change of activation in zwitterionic or neutral micelles and vesicles and low enthalpy change of activation in vesicles constituted of negatively charged phospholipids. The entropy change of activation was compensated by the changes of enthalpy, thus the free energy change of activation ( approximately 500 meV) did not show large variation in vesicles of different lipids.

  19. A center open to the public (United States)

    Cuesta, L.; Vaquerizo, A.; García-Villadangos, M.


    The view to the public of a research center depends, of course, on the quality of its scientific activity but also, to a large extent, on the communication of results and spreading from the center itself. The Center for Astrobiology (CAB, CSIC-INTA) has maintained for some years a place among the leading Spanish scientific centers and the proof is his continued appearance in the media. In this communication we will give an overview of the activities of the Unit for Scientific Culture of CAB to achieve that goal.

  20. Concurrent engineering research center (United States)

    Callahan, John R.


    The projects undertaken by The Concurrent Engineering Research Center (CERC) at West Virginia University are reported and summarized. CERC's participation in the Department of Defense's Defense Advanced Research Project relating to technology needed to improve the product development process is described, particularly in the area of advanced weapon systems. The efforts committed to improving collaboration among the diverse and distributed health care providers are reported, along with the research activities for NASA in Independent Software Verification and Validation. CERC also takes part in the electronic respirator certification initiated by The National Institute for Occupational Safety and Health, as well as in the efforts to find a solution to the problem of producing environment-friendly end-products for product developers worldwide. The 3M Fiber Metal Matrix Composite Model Factory Program is discussed. CERC technologies, facilities,and personnel-related issues are described, along with its library and technical services and recent publications.

  1. Starting Right: Using "Biophilia," Organism Cards, & Key Themes in Biology to Introduce Student-Centered Active-Learning Strategies at the Beginning of a Course (United States)

    Metzger, Kelsey


    To create rich learning experiences, it is important to engage students from the very beginning of a course and lay the foundation for constructing a community of active learners. The activities described here using "organism cards" connect students' previous knowledge to course goals and address key themes in biology while initiating…

  2. Starchild Presents...StarChild: A Learning Center for Young Astronomers. Black Holes. An Information and Activity Booklet. Grades K-8, 1998-1999. (United States)

    Truelove, Elizabeth; Dejoie, Joyce

    The information provided in this booklet is meant to give the necessary background information so that the science of black holes can be taught confidently to elementary students. The featured activities can be used to engage and excite students about the topic of black holes in different disciplines and in a number of ways. Activities include:…

  3. The Life Cycles of Stars: An Information & Activity Booklet Grades K-8, 1997-1998. Star-Child--A Learning Center for Young Astronomers. (United States)

    Truelove, Elizabeth; Dejoie, Joyce

    This booklet contains information and activities on the life cycle of stars. Materials can be adapted for kindergarten through grade 8 classrooms. Background information on massive stars and medium stars and activities with subjects such as star life, constellation shapes, nebula terminology, astronomical distances, and pulsars is included. The 12…

  4. The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells. (United States)

    Whisenant, Thomas C; Peralta, Eigen R; Aarreberg, Lauren D; Gao, Nina J; Head, Steven R; Ordoukhanian, Phillip; Williamson, Jamie R; Salomon, Daniel R


    Activation of CD4 T cells is a reaction to challenges such as microbial pathogens, cancer and toxins that defines adaptive immune responses. The roles of T cell receptor crosslinking, intracellular signaling, and transcription factor activation are well described, but the importance of post-transcriptional regulation by RNA-binding proteins (RBPs) has not been considered in depth. We describe a new model expanding and activating primary human CD4 T cells and applied this to characterizing activation-induced assembly of splicing factors centered on U2AF2. We immunoprecipitated U2AF2 to identify what mRNA transcripts were bound as a function of activation by TCR crosslinking and costimulation. In parallel, mass spectrometry revealed the proteins incorporated into the U2AF2-centered RNA/protein interactome. Molecules that retained interaction with the U2AF2 complex after RNAse treatment were designated as "central" interactome members (CIMs). Mass spectrometry also identified a second class of activation-induced proteins, "peripheral" interactome members (PIMs), that bound to the same transcripts but were not in physical association with U2AF2 or its partners. siRNA knockdown of two CIMs and two PIMs caused changes in activation marker expression, cytokine secretion, and gene expression that were unique to each protein and mapped to pathways associated with key aspects of T cell activation. While knocking down the PIM, SYNCRIP, impacts a limited but immunologically important set of U2AF2-bound transcripts, knockdown of U2AF1 significantly impairs assembly of the majority of protein and mRNA components in the activation-induced interactome. These results demonstrated that CIMs and PIMs, either directly or indirectly through RNA, assembled into activation-induced U2AF2 complexes and play roles in post-transcriptional regulation of genes related to cytokine secretion. These data suggest an additional layer of regulation mediated by the activation-induced assembly of RNA

  5. Coal Ash Behavior in Reducing Environments (CABRE) III Year 6 - Activity 1.10 - Development of a National Center for Hydrogen

    Energy Technology Data Exchange (ETDEWEB)

    Stanislowski, Joshua; Azenkeng, Alexander; McCollor, Donald; Galbreath, Kevin; Jensen, Robert; Lahr, Brent


    The Energy & Environmental Research Center (EERC) has been conducting research on gasification for six decades. One of the objectives of this gasification research has been to maximize carbon conversion and the water–gas shift process for optimal hydrogen production and syngas quality. This research focus and experience were a perfect fit for the National Center for Hydrogen Technology ® (NCHT®) Program at the EERC for improving all aspects of coal gasification, which ultimately aids in the production and purification of hydrogen. A consortia project was developed under the NCHT Program to develop an improved predictive model for ash formation and deposition under the project entitled “Coal Ash Behavior in Reducing Environments (CABRE) III: Development of the CABRE III Model.” The computer-based program is now applicable to the modeling of coal and ash behavior in both entrained-flow and fluidized-bed gasification systems to aid in overall gasification efficiency. This model represents a significant improvement over the CABRE II model and runs on a Microsoft Windows PC platform. The major achievements of the CABRE III model are partitioning of inorganic transformations between various phases for specific gas cleanup equipment; slag property predictions, including standard temperature–viscosity curves and slag flow and thickness; deposition rates in gasification cleanup equipment; provision for composition analysis for all input and output streams across all process equipment, including major elements and trace elements of interest; composition analysis of deposit streams for various deposit zones, including direct condensation on equipment surfaces (Zone A), homogeneous particulate deposition (Zone B), and entrained fly ash deposition (Zone C); and physical removal of ash in cyclones based on D50 cut points. Another new feature of the CABRE III model is a user-friendly interface and detailed reports that are easily exportable into Word documents, Excel

  6. Long-Term Demonstration of Hydrogen Production from Coal at Elevated Temperatures Year 6 - Activity 1.12 - Development of a National Center for Hydrogen Technology

    Energy Technology Data Exchange (ETDEWEB)

    Stanislowski, Joshua; Tolbert, Scott; Curran, Tyler; Swanson, Michael


    The Energy & Environmental Research Center (EERC) has continued the work of the National Center for Hydrogen Technology® (NCHT®) Program Year 6 Task 1.12 project to expose hydrogen separation membranes to coal-derived syngas. In this follow-on project, the EERC has exposed two membranes to coal-derived syngas produced in the pilot-scale transport reactor development unit (TRDU). Western Research Institute (WRI), with funding from the State of Wyoming Clean Coal Technology Program and the North Dakota Industrial Commission, contracted with the EERC to conduct testing of WRI’s coal-upgrading/gasification technology for subbituminous and lignite coals in the EERC’s TRDU. This gasifier fires nominally 200–500 lb/hour of fuel and is the pilot-scale version of the full-scale gasifier currently being constructed in Kemper County, Mississippi. A slipstream of the syngas was used to demonstrate warm-gas cleanup and hydrogen separation using membrane technology. Two membranes were exposed to coal-derived syngas, and the impact of coal-derived impurities was evaluated. This report summarizes the performance of WRI’s patent-pending coalupgrading/ gasification technology in the EERC’s TRDU and presents the results of the warm-gas cleanup and hydrogen separation tests. Overall, the WRI coal-upgrading/gasification technology was shown to produce a syngas significantly lower in CO2 content and significantly higher in CO content than syngas produced from the raw fuels. Warm-gas cleanup technologies were shown to be capable of reducing sulfur in the syngas to 1 ppm. Each of the membranes tested was able to produce at least 2 lb/day of hydrogen from coal-derived syngas.

  7. Effects of local fatigue on myoelectrical activity of erector spine muscles and the center for pressure displacement of the feet during balance recovery following postural perturbation in kyphotic subjects

    Directory of Open Access Journals (Sweden)

    Rooholah Rezaee


    Full Text Available Background: kyphosis deformity affects postural control. Muscular fatigue is one of the factors that can impair the mechanism of body balance. The aim of this study was to determine the effects of local fatigue on the myoelectrical activity of erector spine muscles and the center for pressure displacement of the feet during balance recovery following postural perturbation in kyphotic subjects. Methods: In this quasi-experimental study, 12 male students with>40 degrees thoracic kyphosis and 12 controls were selected to participate in the study. A flexible ruler was used to measure thoracic kyphosis. For postural control assessment, each subject underwent unexpected, forward-backward perturbations while standing on a foot scan mounted on a movable plate triggered by a weight equivalent to 10% of the subjects’ body weight. Experimental procedure was measured before (3 trails and after (3 trials the fatigue protocol. The myoelectric activity of the erector spine and multi fidus was compared in the groups using repeated measures of ANOVA and independent t-test (P<0.05. Results: There was no significant difference in the foot center of pressure displacement in both groups after muscular fatigue. After fatigue, there was an increase in the activity of longissimus thoracis (P=0.001 and iliocostalis thoracis (P= 0.001 in control group, while no significant difference was reported for the muscular activity of multifidus (p=0.084. The activity of langisimus thoracis was significantly increased (P=0.028 in kyphtic group after fatigue. Conclusion: erector spine muscles fatigue could not significantly affect the postural control in both groups, but the electrical activity of erector spine muscles during balance recovery following postural perturbation in kyphotic subjects was different than the controls.

  8. Effects of electrical stimulation of the hunger center in the lateral hypothalamus and food reinforcement on impulse activity of the mylohyoid muscle in rabbits under conditions of hunger and satiety. (United States)

    Ignatova, Ju P; Kromin, A A


    Effects of electrical stimulation of the hunger center in the lateral hypothalamus and food reinforcement on impulse activity of mylohyoid muscle were studied in chronic experiments under conditions of hunger and satiety. Threshold stimulation of the lateral hypothalamus in starving and satiated rabbits in the absence of food induced searching behavior associated with burst-like impulse activity with a bimodal distribution of interpulse intervals. Regular spike burst in the mylohyoid muscle during stimulation of the lateral hypothalamus in the absence of food serves as an example of the anticipatory type reaction. Increased food motivation during threshold stimulation of the lateral hypothalamus in starving and satiated rabbits with food offered led to successful food-procuring behavior, during which the frequency of spike bursts in the mylohyoid muscle became comparable with that under conditions of natural foraging behavior stimulated by the need in nutrients. Our results suggest that temporal structure of mylohyoid muscle impulse activity reflects convergent interactions of food-motivation excitation with reinforcement excitation on neurons of the masticatory and deglutitive centers.

  9. Hydrologic Engineering Center (United States)

    Federal Laboratory Consortium — The Hydrologic Engineering Center (HEC), an organization within the Institute for Water Resources, is the designated Center of Expertise for the U.S. Army Corps of...

  10. NIH Clinical Centers (United States)

    Federal Laboratory Consortium — The NIH Clinical Center consists of two main facilities: The Mark O. Hatfield Clinical Research Center, which opened in 2005, houses inpatient units, day hospitals,...

  11. Center for Women Veterans (United States)

    ... Aid & Attendance & Housebound Caregivers Community Living Centers (CLC) Community Nursing Homes Domiciliaries (Please contact your local VA Medical Center) Homemaker & Home Health Aid Care Hospice and Palliative Care State Veterans ...

  12. Day Care Centers (United States)

    Department of Homeland Security — This database contains locations of day care centers for 50 states and Washington D.C. and Puerto Rico. The dataset only includes center based day care locations...

  13. Poison Control Centers (United States)

    ... 1222 immediately. Name State American Association of Poison Control Centers Address AAPCC Central Office NOT A POISON ... not for emergency use. Arkansas ASPCA Animal Poison Control Center Address 1717 S. Philo Road, Suite 36 Urbana, ...

  14. Center of Attention. (United States)

    Coffey, J. Steven; Wood-Steed, Ruth


    Illustrates how college and university student centers are becoming the institution's marketing tools. Explores how the Millennium Center at the University of Missouri in St. Louis exemplifies this new trend. (GR)

  15. RSW Cell Centered Grids (United States)

    National Aeronautics and Space Administration — New cell centered grids are generated to complement the node-centered ones uploaded. Six tarballs containing the coarse, medium, and fine mixed-element and pure tet....


    Federal Laboratory Consortium — The Maryland Robotics Center is an interdisciplinary research center housed in the Institute for Systems Research (link is external)within the A. James Clark School...

  17. National Rehabilitation Information Center (United States)

    ... including News and Notes) Welcome to the National Rehabilitation Information Center! We are conducting improvements to the ... experience. We apologize for any inconvenience The National Rehabilitation Information Center ( NARIC ) is the library of the ...


    Federal Laboratory Consortium — The Maryland Robotics Center is an interdisciplinary research center housed in the Institute for Systems Research (link is external) within the A. James Clark School...

  19. Automating the Media Center. (United States)

    Holloway, Mary A.


    Discusses the need to develop more efficient information retrieval skills by the use of new technology. Lists four stages used in automating the media center. Describes North Carolina's pilot programs. Proposes benefits and looks at the media center's future. (MVL)

  20. Center for Functional Nanomaterials (United States)

    Federal Laboratory Consortium — The Center for Functional Nanomaterials (CFN) explores the unique properties of materials and processes at the nanoscale. The CFN is a user-oriented research center...

  1. Center of Excellence in laser medicine. Progress performance report

    Energy Technology Data Exchange (ETDEWEB)

    Parrish, J.A.


    Achievements during the last 12 months of funding to initiate a Center of Excellence in biomedical laser development include: seven specific research projects within the Center`s three broad interest areas, and program development to establish the MGH Laser Center and its activities. Progress in the three interest areas namely new medical laser systems development, optical diagnostics and photo sensitization is reported. Feasibility studies and prototype development were emphasized, to enhance establishing a substantial Center through future support. Specific projects are outlined below. In addition, the interdepartmental MGH Laser Center`s activities and accomplishments.

  2. Exposing the Data Center


    Sergejev, Ivan


    Given the rapid growth in the importance of the Internet, data centers - the buildings that store information on the web - are quickly becoming the most critical infrastructural objects in the world. However, so far they have received very little, if any, architectural attention. This thesis proclaims data centers to be the 'churches' of the digital society and proposes a new type of a publicly accessible data center. The thesis starts with a brief overview of the history of data centers ...

  3. Report: Review of Hotline Complaint on EPA’s Pre-Award Activities for Multiple Award Contracts at the National Computer Center (United States)

    Report #13-P-0220, April 15, 2013. We found no evidence to support allegations made in the complaint. However, we determined that the EPA could improve communications with vendors during pre-award activities.

  4. Colleges and Universities Highway Traffic and Safety Centers. (United States)

    Aaron, James E., Ed.; Ritzel, Dale O., Ed.

    After consideration of the organizing of university safety centers and the growth and role of such centers in the future, descriptions are presented of the activities and practices in each of 16 existing college and university highway traffic and safety centers. Information is presented regarding center objectives, programs, staff composition,…

  5. Data center cooling method

    Energy Technology Data Exchange (ETDEWEB)

    Chainer, Timothy J.; Dang, Hien P.; Parida, Pritish R.; Schultz, Mark D.; Sharma, Arun


    A method aspect for removing heat from a data center may use liquid coolant cooled without vapor compression refrigeration on a liquid cooled information technology equipment rack. The method may also include regulating liquid coolant flow to the data center through a range of liquid coolant flow values with a controller-apparatus based upon information technology equipment temperature threshold of the data center.

  6. 基于时间驱动作业成本法的配送中心作业优化%Operation optimization of distribution center based on time-driven activity-based costing

    Institute of Scientific and Technical Information of China (English)

    杨华龙; 陈志俊; 计莹峰; 张燕


    In order to improve the operation,efficiency and effectiveness of distribution center,this paper analyzes the operation optimization problem of distribution center by using time-driven activity-based costing(TDABC).An operation optimization model is established with the objectives of decreasing the number of workers and increasing the rate of time efficiency in distribution center.And the constraints of operation in distribution center are optimized and controlled based on theory of constraint.The process and its steps of the optimization model are designed.Numerical examples show that the model and its optimization process are easy to implement and solve the problems,and the application results are quite well,which verifies the feasibility and validity of the model and its optimization process.%为提高配送中心作业的效率和效益,应用时间驱动作业成本法,对配送中心各作业优化问题进行分析.以降低配送中心作业员工数额和提高有效时间利用率为优化目标,建立配送中心作业优化模型,并依据约束理论对配送中心作业的约束进行优化控制,设计模型的优化流程步骤.数值实验分析结果表明,该模型及优化流程易于实施求解,应用效果良好,从而验证了模型及其优化流程的可行性和有效性.

  7. Hard X-ray Morphological and Spectral Studies of The Galactic Center Molecular Cloud Sgr B2: Constraining Past Sgr A* Flaring Activity

    CERN Document Server

    Zhang, Shuo; Mori, Kaya; Clavel, Maïca; Terrier, Régis; Ponti, Gabriele; Goldwurm, Andrea; Bauer, Franz E; Boggs, Steven E; Craig, William W; Christensen, Finn E; Harrison, Fiona A; Hong, Jaesub; Nynka, Melania; Stern, Daniel; Soldi, Simona; Tomsick, John A; Zhang, William W


    Galactic Center (GC) molecular cloud Sgr B2 is the best manifestation of an X-ray reflection nebula (XRN) reprocessing a past giant outburst from the supermassive black hole Sgr A*. Alternatively, Sgr B2 could be illuminated by low-energy cosmic ray electrons (LECRe) or protons (LECRp). In 2013, NuSTAR for the first time resolved Sgr B2 hard X-ray emission on sub-arcminute scales. Two prominent features are detected above 10 keV - a newly emerging cloud G0.66-0.13 and the central 90" radius region containing two compact cores Sgr B2(M) and Sgr B2(N) surrounded by diffuse emission. It is inconclusive whether the remaining level of Sgr B2 emission is still decreasing or has reached a constant background level. A decreasing Fe K$\\alpha$ emission can be best explained by XRN while a constant background emission can be best explained by LECRp. In the XRN scenario, the 3-79 keV Sgr B2 spectrum can well constrain the past Sgr A* outburst, resulting in an outburst spectrum with a peak luminosity of $L_{3-79\\rm~keV} \\...

  8. The First 2 Years of Activity of a Specialized Organ Procurement Center: Report of an Innovative Approach to Improve Organ Donation. (United States)

    Marsolais, P; Durand, P; Charbonney, E; Serri, K; Lagacé, A-M; Bernard, F; Albert, M


    The number of patients requiring organ transplants continues to outgrow the number of organs donated each year. In an attempt to improve the organ donation process and increase the number of organs available, we created a specialized multidisciplinary team within a specialized organ procurement center (OPC) with dedicated intensive care unit (ICU) beds and operating rooms. The OPC was staffed with ICU nurses, operating room nurses, organ donor management ICU physicians, and multidisciplinary staff. All organ donors within a designated geographic area were transferred to and managed within the OPC. During the first 2 years of operation, 126 patients were referred to the OPC. The OPC was in use for a total of 3527 h and involved 253 health workers. We retrieved 173 kidneys, 95 lungs, 68 livers, 37 hearts, and 13 pancreases for a total of 386 organs offered for transplantation. This translates to a total of 124.6 persons transplanted per million population, which compares most favorably to recently published numbers in developed countries. The OPC clearly demonstrates potential to increase the number of deceased donor organs available for transplant. Further studies are warranted to better understand the exact influence of the different components of the OPC on organ procurement.


    Energy Technology Data Exchange (ETDEWEB)



    Computational Science is an integral component of Brookhaven's multi science mission, and is a reflection of the increased role of computation across all of science. Brookhaven currently has major efforts in data storage and analysis for the Relativistic Heavy Ion Collider (RHIC) and the ATLAS detector at CERN, and in quantum chromodynamics. The Laboratory is host for the QCDOC machines (quantum chromodynamics on a chip), 10 teraflop/s computers which boast 12,288 processors each. There are two here, one for the Riken/BNL Research Center and the other supported by DOE for the US Lattice Gauge Community and other scientific users. A 100 teraflop/s supercomputer will be installed at Brookhaven in the coming year, managed jointly by Brookhaven and Stony Brook, and funded by a grant from New York State. This machine will be used for computational science across Brookhaven's entire research program, and also by researchers at Stony Brook and across New York State. With Stony Brook, Brookhaven has formed the New York Center for Computational Science (NYCCS) as a focal point for interdisciplinary computational science, which is closely linked to Brookhaven's Computational Science Center (CSC). The CSC has established a strong program in computational science, with an emphasis on nanoscale electronic structure and molecular dynamics, accelerator design, computational fluid dynamics, medical imaging, parallel computing and numerical algorithms. We have been an active participant in DOES SciDAC program (Scientific Discovery through Advanced Computing). We are also planning a major expansion in computational biology in keeping with Laboratory initiatives. Additional laboratory initiatives with a dependence on a high level of computation include the development of hydrodynamics models for the interpretation of RHIC data, computational models for the atmospheric transport of aerosols, and models for combustion and for energy utilization. The CSC was formed to

  10. Operation of the power information center: Performance of secretariat functions and information exchange activities in the advanced power field of the interagency advanced power group (United States)


    Highlights of activities conducted during the reporting period to facilitate the exchange of technical information among scientists and engineers both within the federal government and within industry are cited. Interagency Advanced Power Group meetings and special efforts, project briefs, and organization development are considered.

  11. Student Perceptions of Learner-Centered Teaching (United States)

    Wohlfarth, DeDe; Sheras, Daniel; Bennett, Jessica L.; Simon, Bethany; Pimentel, Jody H.; Gabel, Laura E.


    The learner-centered paradigm departs from traditional teaching models by focusing on students more than teachers and learning more than teaching. Thus, classes are more egalitarian; they emphasize critical thinking, active learning, and real-world assignments. Graduate students in learner-centered classrooms were surveyed about perceptions of…

  12. Stennis Space Center celebrates Native American culture (United States)


    Famie Willis (left), 2009-2010 Choctaw Indian Princess, displays artifacts during Native American Heritage Month activities at Stennis Space Center on Nov. 24. The celebration featured various Native American cultural displays for Stennis employees to view. Shown above are (l to r): Willis, Elaine Couchman of NASA Shared Services Center, John Cecconi of NSSC and Lakeisha Robertson of the Environmental Protection Agency.

  13. 重心轨迹运动平衡训练和测试的实现及初步观察%Active control of the trajectory of the center of gravity in balance training

    Institute of Scientific and Technical Information of China (English)

    邹任玲; 胡秀枋; 徐秀林; 李放; 吴毅


    Objective To study the impact of active control of the trajectory of the center of gravity on the effectiveness of balance training and balance assessment. Methods Two groups of subjects ( group 1 30-45 years old, group 2 45-60 years old ) were evaluated and trained using both active center of gravity trajectory control and static balance methods. Results The percentages of success in controlling the center of gravity were the same when both groups were trained using static balance. Group 1's success percentage was higher than that of group 2 after active center of gravity trajectory training. Their affected lower limbs performed better in wave trace training than after static balance training, and performance improved with increased wave trace amplitude. Conclusions Wave tracing can stimulate the lower limbs of patients with active control force and improve their balance. The wave assessment is superior to static assessment, as it can objectively reflect ability in active center of gravity control and adjust the lower limbs of subjects whose static balance ability is at the same level.%目的 研究主动控制重心对平衡训练及平衡评估的影响.方法 设计重心轨迹运动平衡训练及评估系统,将受试者分别采用静态平衡和重心波浪轨迹运动两种方式进行测试评估.平衡训练的方法是将偏瘫患者在静态平衡和重心波浪轨迹运动两种方式进行训练.结果 2组受试者在静态平衡下,良好重心控制百分比结果相同,在重心轨迹运动站立平衡方式下,受试一组的良好重心控制百分比值均高于受试二组;偏瘫患者训练结果为波浪轨迹训练比静态平衡训练时的偏瘫侧下肢平均用力大,而且偏瘫侧下肢平均用力随着波浪轨迹幅度增大而增大.结论 运用波浪方式训练,能有效加强患者的偏瘫侧训练,提高平衡调节能力;运用波浪方式评估,能克服目前静态平衡时无法对患者主动控制重心训练评估

  14. Is [FeO](2+) the active center also in iron containing zeolites? A density functional theory study of methane hydroxylation catalysis by Fe-ZSM-5 zeolite. (United States)

    Rosa, Angela; Ricciardi, Giampaolo; Jan Baerends, Evert


    Arguments are put forward that the active alpha-oxygen site in the Fe-ZSM-5 catalyst consists of the FeO(2+) moiety. It is demonstrated that this zeolite site for FeO(2+) indeed obeys the design principles for high reactivity of the FeO(2+) moiety proposed earlier: a ligand environment consisting of weak equatorial donors (rather oxygen based than nitrogen based) and very weak or absent trans axial donor. The alpha-oxygen site would then owe its high reactivity to the same electronic structure features that lends FeO(2+) its high activity in biological systems, as well as in the classical Fenton chemistry.

  15. Student Perceptions of Learner-Centered Teaching

    Directory of Open Access Journals (Sweden)

    DeDe Wohlfarth


    Full Text Available The learner-centered paradigm departs from traditional teaching models by focusing on students more than teachers and learning more than teaching. Thus, classes are more egalitarian; they emphasize critical thinking, active learning, and real-world assignments. Graduate students in learner-centered classrooms were surveyed about perceptions of their experiences in relation to the key dimensions of the learner-centered paradigm and noted that the approach contributed to their feeling respected as learners, developed their critical thinking skills, and encouraged their self-directedness. Based on these findings, post-secondary instructors are encouraged to experiment with learning-centered approaches to further explore this promising model.

  16. Centering on Sea Life in the Classroom. (United States)

    Gruendike, Janis L.


    Describes an oceanography learning center for elementary/middle school students, focusing on use of games (review jeopardy), instructional tapes, flash cards, activity felt boards, picture puzzles, reading materials, science displays, and experiment stations. (JN)

  17. National Center for Advancing Translational Sciences (United States)

    ... activities. Licensing Opportunities NCATS makes it easy for industry and academia to interact and partner with Center laboratories and ... and Healthcare Products Regulatory Agency (“MHRA”) Designates VTS-270 as ...

  18. Carbon dioxide Information Analysis Center and World Data Center: A for Atmospheric trace gases. Annual progress report, FY 1994

    Energy Technology Data Exchange (ETDEWEB)

    Burtis, M.D. [comp.] [Tennessee Univ., Knoxville, TN (United States). Energy, Environment and Resources Center; Cushman, R.M.; Boden, T.A.; Jones, S.B.; Nelson, T.R.; Stoss, F.W. [Oak Ridge National Lab., TN (United States)


    This report summarizes the activities and accomplishments made by the Carbon Dioxide Information Analysis Center and World Data Center-A for Atmospheric Trace Gases during the fiscal year 1994. Topics discussed in this report include; organization and staff, user services, systems, communications, Collaborative efforts with China, networking, ocean data and activities of the World Data Center-A.

  19. A longitudinal study of changes in asylum seekers ability regarding activities of daily living during their stay in the asylum center

    DEFF Research Database (Denmark)

    Morville, Anne-Le; Amris, Kirstine; Eklund, Mona;


    The aim was to assess change in activities of daily living (ADL) ability amongst asylum seekers and if there were any difference between tortured and non-torture following a 10 months post-arrival period, and if self-reported health and exposure to torture were factors related to change in ADL...... participated. ADL-ability was measured using Assessment of Motor and Process Skills and questionnaires about exposure to torture, self-reported mental health and pain. ADL motor and process measures, well-being and self-rated health declined from baseline to follow-up. Measures of pain and depression increased...

  20. Us'em: the user-centered design of a device for motivating stroke patients to use their impaired arm-hand in daily life activities. (United States)

    Markopoulos, Panos; Timmermans, Annick A A; Beursgens, Luuk; van Donselaar, Rik; Seelen, Henk A M


    Stroke leaves the majority of its survivors with an impairment of the upper extremity that affects their ability to live independently and their quality of life. Rehabilitation research shows that practice of everyday life activities in a natural context may sustain or even improve arm-hand performance, even during chronic stages after stroke. Based on this insight we designed, developed and evaluated Us'em; this consists of two watch-like accelerometry devices that provide feedback to stroke patients regarding the usage of their impaired versus their non-affected upper extremity. System usability and treatment credibility/expectancy were evaluated positively by therapists and patients.

  1. Test Control Center exhibit (United States)


    Have you ever wondered how the engineers at John C. Stennis Space Center in Hancock County, Miss., test fire a Space Shuttle Main Engine? The Test Control Center exhibit at StenniSphere can answer your questions by simulating the test firing of a Space Shuttle Main Engine. A recreation of one of NASA's test control centers, the exhibit explains and portrays the 'shake, rattle and roar' that happens during a real test firing.

  2. Relativistic Guiding Center Equations

    Energy Technology Data Exchange (ETDEWEB)

    White, R. B. [PPPL; Gobbin, M. [Euratom-ENEA Association


    In toroidal fusion devices it is relatively easy that electrons achieve relativistic velocities, so to simulate runaway electrons and other high energy phenomena a nonrelativistic guiding center formalism is not sufficient. Relativistic guiding center equations including flute mode time dependent field perturbations are derived. The same variables as used in a previous nonrelativistic guiding center code are adopted, so that a straightforward modifications of those equations can produce a relativistic version.

  3. Center of excellence in laser medicine

    Energy Technology Data Exchange (ETDEWEB)

    Parrish, J.A.


    Achievements during the first six months of funding to prepare for a Center of Excellence in biomedical laser development include limited specific research projects within the Center's three broad interest areas, and program development to establish the Center and its activities. Progress in the three interest areas -- new medical laser systems development, optical diagnostics, and photosensitization, is reported. Feasibility studies and prototype development were emphasized, to enhance establishing a substantial Center through future support. Specific projects are an optimized laser-catheter system for reversal of vasospasm; optical detection of major skin burn depth and cancers using fluorescent drugs, and photosensitization of vascular tissues. In addition, an interdepartmental Laser Center was established at MGH to enhance collaborations and institutional committment to the Center of Excellence. Competitive postdoctoral research fellowships, with provision for matching funds from other departments, have been announced.

  4. Great Lakes Science Center (United States)

    Federal Laboratory Consortium — Since 1927, Great Lakes Science Center (GLSC) research has provided critical information for the sound management of Great Lakes fish populations and other important...

  5. Small Business Development Center (United States)

    Small Business Administration — Small Business Development Centers (SBDCs) provide assistance to small businesses and aspiring entrepreneurs throughout the United States and its territories. SBDCs...

  6. Advanced Simulation Center (United States)

    Federal Laboratory Consortium — The Advanced Simulation Center consists of 10 individual facilities which provide missile and submunition hardware-in-the-loop simulation capabilities. The following...

  7. Environmental Modeling Center (United States)

    Federal Laboratory Consortium — The Environmental Modeling Center provides the computational tools to perform geostatistical analysis, to model ground water and atmospheric releases for comparison...

  8. Surgery center joint ventures. (United States)

    Zasa, R J


    Surgery centers have been accepted as a cost effective, patient friendly vehicle for delivery of quality ambulatory care. Hospitals and physician groups also have made them the vehicles for coming together. Surgery centers allow hospitals and physicians to align incentives and share benefits. It is one of the few types of health care businesses physicians can own without anti-fraud and abuse violation. As a result, many surgery center ventures are now jointly owned by hospitals and physician groups. This article outlines common structures that have been used successfully to allow both to own and govern surgery centers.

  9. Test Control Center (TCC) (United States)

    Federal Laboratory Consortium — The Test Control Center (TCC) provides a consolidated facility for planning, coordinating, controlling, monitoring, and analyzing distributed test events. ,The TCC...

  10. Data Center at NICT (United States)

    Ichikawa, Ryuichi; Sekido, Mamoru


    The Data Center at the National Institute of Information and Communications Technology (NICT) archives and releases the databases and analysis results processed at the Correlator and the Analysis Center at NICT. Regular VLBI sessions of the Key Stone Project VLBI Network were the primary objective of the Data Center. These regular sessions continued until the end of November 2001. In addition to the Key Stone Project VLBI sessions, NICT has been conducting geodetic VLBI sessions for various purposes, and these data are also archived and released by the Data Center.

  11. Chemical Security Analysis Center (United States)

    Federal Laboratory Consortium — In 2006, by Presidential Directive, DHS established the Chemical Security Analysis Center (CSAC) to identify and assess chemical threats and vulnerabilities in the...

  12. Airline Operation Center Workstation (United States)

    Department of Transportation — The Airline Operation Center Workstation (AOC Workstation) represents equipment available to users of the National Airspace system, outside of the FAA, that enables...

  13. Center for Deployment Psychology (United States)

    Federal Laboratory Consortium — The Center for Deployment Psychology was developed to promote the education of psychologists and other behavioral health specialists about issues pertaining to the...

  14. Electron Microscopy Center (EMC) (United States)

    Federal Laboratory Consortium — The Electron Microscopy Center (EMC) at Argonne National Laboratory develops and maintains unique capabilities for electron beam characterization and applies those...

  15. Audio Visual Center (United States)

    Federal Laboratory Consortium — The Audiovisual Services Center provides still photographic documentation with laboratory support, video documentation, video editing, video duplication, photo/video...

  16. [Effect of electrostimulation "hunger center" of lateral hypothalamus on the impulse activity of masticatory muscles in unfed and fed rabbits in the absence and the presence of food]. (United States)

    Ignatova, Iu P; Kromin, A A


    In chronic experiences on rabbits the influence of electrostimulation of "the hunger centres" of the lateral hypothalamus (LH) on impulse activity of chewing muscles of rabbits under the conditions of hunger and satiation was studied. It is established, threshold irritation of the LH of hungry and preliminary fed animals in the absence of food caused the occurrence of incessant search behavior which was followed by the regular generation of bursts of AP by masseter and mylohyoideus muscles with bimodal distributions of interpulse intervals. Such reaction of chewing muscles during irritation of the LH in the absence of food is an example of advancing type reaction. The increase of level of alimentary motivation, arising at threshold irritation of the LH of rabbits under the conditions of hunger and satiety during the resultant food-intake behavior, increased frequency of generation of bursts of AP in a phase of the capture of food, but did not influence on this indicator in a phase of chewing of food. The received results testify about descending stimulating influences of alimentary motivational excitation on neurons of the chewing centre in medulla and on impulse activity of chewing muscles.

  17. Postsynthetic Metal and Ligand Exchange in MFU-4l: A Screening Approach toward Functional Metal-Organic Frameworks Comprising Single-Site Active Centers. (United States)

    Denysenko, Dmytro; Jelic, Jelena; Reuter, Karsten; Volkmer, Dirk


    The isomorphous partial substitution of Zn(2+) ions in the secondary building unit (SBU) of MFU-4l leads to frameworks with the general formula [M(x)Zn(5-x)Cl4(BTDD)3], in which x≈2, M = Mn(II), Fe(II), Co(II), Ni(II), or Cu(II), and BTDD = bis(1,2,3-triazolato-[4,5-b],[4',5'-i])dibenzo-[1,4]-dioxin. Subsequent exchange of chloride ligands by nitrite, nitrate, triflate, azide, isocyanate, formate, acetate, or fluoride leads to a variety of MFU-4l derivatives, which have been characterized by using XRPD, EDX, IR, UV/Vis-NIR, TGA, and gas sorption measurements. Several MFU-4l derivatives show high catalytic activity in a liquid-phase oxidation of ethylbenzene to acetophenone with air under mild conditions, among which Co- and Cu derivatives with chloride side-ligands are the most active catalysts. Upon thermal treatment, several side-ligands can be transformed selectively into reactive intermediates without destroying the framework. Thus, at 300 °C, Co(II)-azide units in the SBU of Co-MFU-4l are converted into Co(II)-isocyanate under continuous CO gas flow, involving the formation of a nitrene intermediate. The reaction of Cu(II)-fluoride units with H2 at 240 °C leads to Cu(I) and proceeds through the heterolytic cleavage of the H2 molecule.

  18. Rationale and protocol of the MetNET-1 trial, a prospective, single center, phase II study to evaluate the activity and safety of everolimus in combination with octreotide LAR and metformin in patients with advanced pancreatic neuroendocrine tumors. (United States)

    Pusceddu, Sara; de Braud, Filippo; Concas, Laura; Bregant, Cristina; Leuzzi, Livia; Formisano, Barbara; Buzzoni, Roberto


    Abnormal PI3K-AKT-mTOR pathway signalling and autocrine activation of the mTOR pathway, mediated through insulin-like growth factor-1, have been implicated in the proliferation of pancreatic neuroendocrine tumor (pNET) cells. Everolimus, an mTOR inhibitor, has shown antitumor benefit in pNETs alone and in combination with octreotide LAR in RADIANT-1 and RADIANT-3 studies. Although everolimus-based phase II/III trials have improved progression-free survival for pNET, its use has not impacted on prolonging overall survival. Metformin has recently shown some anti-cancer activity in both in vitro and in vivo studies by its indirect properties to decrease insulin and insulin-like growth factor-1 (IGF-1) levels and by its antitumour effect to promote AMPK activation and consequently inhibition to TSC1-2/mTOR complex. In light of even more retrospective evidence of metformin's anticancer activity, a prospective evaluation is required to either confirm or discard these preliminary findings. With the aim to evaluate the antiproliferative effect of metformin in combination with everolimus and octreotide LAR in pancreatic well-differentiated neuroendocrine tumor patients, a single arm, prospective, single center phase II study was designed (MetNET-1 trial, NCT 02294006). Forty-three patients are expected to be evaluated. The study is ongoing, and recruitment is estimated to be completed in August 2016. The results will be anticipated in 2017.

  19. Modifications of laccase activities of copper efflux oxidase, CueO by synergistic mutations in the first and second coordination spheres of the type I copper center. (United States)

    Kataoka, Kunishige; Kogi, Hiroki; Tsujimura, Seiya; Sakurai, Takeshi


    The redox potential of type I copper in the Escherichia coli multicopper oxidase CueO was shifted in the positive or negative direction as a result of the single, double, and triple mutations in the first and second coordination spheres: the formation of the NH···S(-)(Cys500 ligand) hydrogen bond, the breakdown of the NH(His443 ligand)···O(-)(Asp439) hydrogen bond, and the substitution of the Met510 ligand for the non-coordinating Leu or coordinating Gln. Laccase activities of CueO were maximally enhanced 140-fold by virtue of the synergistic effect of mild mutations at and at around the ligand groups to type I copper.

  20. Effect of weight-bearing activity on the center of rotation in the lower lumbar vertebrae%负重状态对下腰椎椎体间旋转中心的影响

    Institute of Scientific and Technical Information of China (English)

    刘佳男; 夏群; 苗军; 李宏达; 魏冬


    BACKGROUND:Epidemiologic reports have indicated that excessive weight-bearing exercise is one of important risk factors for lumbar degeneration, but the effects of weight-bearing activity on normal lumbar motion pattern are stil not clear. OBJECTIVE:To measure the changing characteristics and rules of position at the center of rotation of the lower lumbar spine during a weight-lifting activity of normal person. METHODS: Fourteen asymptomatic subjects with a mean age of (25±5) years were recruited for this study. The L4-5 and L5-S1 segments of each subject were CT-scanned to construct 3D models using dual X-ray imaging system and spiral CT examination combined technology in the aid of computer software. The physiological load and lumbar spinal 3D motion under the loading condition were reproduced when matching the flexion, neutrality and extension in the dual X-ray imaging system and on dual oblique lumbar X-ray image. Coordinate systems were established at the vertebral body of L4-S1 to obtain the center of rotation during flexion-to-neutral, neutral-to-extension and the ful flexion-extension motion. RESULTS AND CONCLUSION: (1) Under physiological load, the center of rotation of L4-5 of normal person was located about 1.0 mm anterior to the central axis of the vertebral body, and the center of rotation of L5-S1 was located about 0.7 mm anterior to the central axis of the vertebral body. (2) With weight loading, the center of rotation of both two segments shifted backward about 0.5 mm. There was no statistical difference between these two loading conditions. (3) When the center of rotation in flexion and extension was calculated respectively, the moving range of the center of rotation at both L4-5and L5-S1 became larger due to taking loads of 10 kg (P < 0.05). In flexion, the center of rotation at L5-S1 significantly shifted forward during a weight-lifting activity (P < 0.05). (4) These results confirm that compared with non-weight-bearing condition, the trajectory

  1. Funding Opportunity: Genomic Data Centers (United States)

    Funding Opportunity CCG, Funding Opportunity Center for Cancer Genomics, CCG, Center for Cancer Genomics, CCG RFA, Center for cancer genomics rfa, genomic data analysis network, genomic data analysis network centers,

  2. Redox activation of Fe(III)-thiosemicarbazones and Fe(III)-bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping. (United States)

    Myers, Judith M; Cheng, Qing; Antholine, William E; Kalyanaraman, Balaraman; Filipovska, Aleksandra; Arnér, Elias S J; Myers, Charles R


    Thiosemicarbazones such as Triapine (Tp) and Dp44mT are tridentate iron (Fe) chelators that have well-documented antineoplastic activity. Although Fe-thiosemicarbazones can undergo redox cycling to generate reactive species that may have important roles in their cytotoxicity, there is only limited insight into specific cellular agents that can rapidly reduce Fe(III)-thiosemicarbazones and thereby promote their redox activity. Here we report that thioredoxin reductase-1 (TrxR1) and glutathione reductase (GR) have this activity and that there is considerable specificity to the interactions between specific redox centers in these enzymes and various Fe(III) complexes. Site-directed variants of TrxR1 demonstrate that the selenocysteine (Sec) of the enzyme is not required, whereas the C59 residue and the flavin have important roles. Although TrxR1 and GR have analogous C59/flavin motifs, TrxR is considerably faster than GR. For both enzymes, Fe(III)(Tp)2 is reduced faster than Fe(III)(Dp44mT)2. This reduction promotes redox cycling and the generation of hydroxyl radical (HO) in a peroxide-dependent manner, even with low-micromolar levels of Fe(Tp)2. TrxR also reduces Fe(III)-bleomycin and this activity is Sec-dependent. TrxR cannot reduce Fe(III)-EDTA at significant rates. Our findings are the first to demonstrate pro-oxidant reductive activation of Fe(III)-based antitumor thiosemicarbazones by interactions with specific enzyme species. The marked elevation of TrxR1 in many tumors could contribute to the selective tumor toxicity of these drugs by enhancing the redox activation of Fe(III)-thiosemicarbazones and the generation of reactive oxygen species such as HO.

  3. Solid Organ Transplantation in Patients with Inflammatory Bowel Diseases (IBD: Analysis of Transplantation Outcome and IBD Activity in a Large Single Center Cohort.

    Directory of Open Access Journals (Sweden)

    Fabian Schnitzler

    Full Text Available Currently, limited data of the outcome of inflammatory bowel disease (IBD in patients after solid organ transplantation (SOT are available. We aimed to analyze effects of SOT on the IBD course in a large IBD patient cohort.Clinical data from 1537 IBD patients were analyzed for patients who underwent SOT (n = 31 between July 2002 and May 2014. Sub-analyses included SOT outcome parameters, IBD activity before and after SOT, and efficacy of IBD treatment.4.74% of patients with ulcerative colitis (UC and 0.84% of patients with Crohn's disease (CD underwent SOT (p = 2.69 x 10(-6, UC vs. CD. 77.4% of patients with SOT underwent liver transplantation (LTx with tacrolimus-based immunosuppressive therapy after SOT. All LTx were due to primary sclerosing cholangitis (PSC or PSC overlap syndromes. Six patients (19.4% required renal transplantation and one patient (3.2% heart transplantation. A survival rate of 83.9% after a median follow-up period of 103 months was observed. Before SOT, 65.0% of patients were in clinical remission and 5 patients received immunosuppressive therapy (16.1%. After SOT, 61.0% of patients were in remission (p = 1.00 vs. before SOT and 29.0% required IBD-specific immunosuppressive or anti-TNF therapy (p = 0.54 vs. before SOT. 42.9% of patients with worsening of IBD after SOT were at higher risk of needing steroid therapy for increased IBD activity (p = 0.03; relative risk (RR: 10.29; 95% CI 1.26-84.06. Four patients (13.0% needed anti-TNF therapy after SOT (response rate 75%.SOT was more common in UC patients due to the higher prevalence of PSC-related liver cirrhosis in UC. Despite mainly tacrolimus-based immunosuppressive regimens, outcome of SOT and IBD was excellent in this cohort. In this SOT cohort, concomitant immunosuppressive therapy due to IBD was well tolerated.

  4. Information Centers at NAL. (United States)

    Frank, Robyn C.


    Descriptions of the 12 specialized information centers of the National Agricultural Library (NAL) include subject coverage, information services provided, information technologies used, and staffing. The development of the Rural Information Center, a joint venture between the Extension Service and NAL to provide information services to local…

  5. Assessing the Assessment Center. (United States)

    LaRue, James


    Describes the historical use of assessment centers as staff development and promotional tools and their current use in personnel selection. The elements that constitute a true assessment center are outlined, and a discussion of the advantages and disadvantages for employers and applicants focuses on positions in library administration. (10…

  6. Handbook for Learning Centers. (United States)

    Norwalk Board of Education, CT.

    The handbook for learning centers contains guidelines, forms, and supplementary information to be used with all children identified as having a learning disability, mild retardation, or sensory deprivation in the Norwalk, Connecticut public schools. It is stressed that the learning center should provide supportive services for at least 35 minutes…

  7. [Activities of the National Information Center for Biological Agents present at workplace and preliminary analysis of data collected by the National Register of Biological Agents]. (United States)

    Kozajda, Anna; Szadkowska-Stańczyk, Irena


    The National Information Centre for Biological Agents Present at Workplaces and the National Register of Biological Agents were established in the Nofer Institute of Occupational Medicine in 2005. The former carries out consultation and education activities concerned with occupational exposure and risk assessment, planning and implementation of preventive programs and accurate registration of reliable information about the use of biological agents. The latter aims at collecting and analyzing the aforesaid information obtained from employers for research, diagnostic or industrial purposes. The data base is a source of information for occupational environment supervising inspections and occupational health service. useful among others in planning various forms of prevention. As of December 10, 2008 there were 281 notifications from companies using biological agents (for the following purposes: research--34, diagnostic--225 and industrial--22). The majority of notifications were obtained from different diagnostic laboratories and universities/ research institutes. In total, 2197 workers, including 2011 (91.5%) women and 186 (8.5%) men were exposed to biological agents, were registered.

  8. A temperature-induced absorption band centered in the region of 666 nm related to the configuration of the active site in frozen cytochrome oxidase. (United States)

    Denis, M; Clore, G M


    The existence of a temperature-induced absorption band centred in the region of 666 nm is demonstrated for both membrane-bound and soluble cytochrome oxidase in the frozen state. The 666 nm band is generated solely by an increase in temperature of both fully reduced and mixed valence state cytochrome oxidase in the presence of CO or O2 within the 'pocket' containing the active site; it is not formed in the absence of both CO and O2 from the sample. The formation of the 666 nm band is entirely reversible when the temperature is decreased again and its formation is not dependent on the presence of liganded CO at the sixth coordination site of haem a3 in the low temperature range (below --120 degrees C) prior to photolysis. The shape and intensity of the 666 nm band are not affected by the extent of CO recombination following flash and photolysis and temperature increase and are not affected by changes in the valence states of the four metal centres when the O2 reaction is in progress.

  9. The DLESE Community Services Center (United States)

    Geary, E.; Aivazian, B.; Manduca, C.; Mogk, D.


    The DLESE Community Services Center (DCSC) is one of several centers recently funded by the National Science Foundation to promote greater and more effective use of Digital Library resources. The primary goals of the DCSC are to: (1) increase the current resource user and contributor base to include greater numbers of K-12, informal, and college educators and students, (2) diversify the DLESE user and contributor base to include rich and robust representation of ethnic, cultural, and differently-abled groups, (3) improve the ability of users and contributors to easily find, adapt, and use high quality digital resources in their classrooms, laboratories, and communities and (4) demonstrate how DLESE can support community activity addressing issues in geoscience education. During the course of the next three years we will: (a) solicit, create, and disseminate "exemplars" that highlight effective digital resource use in a variety of diverse educational settings, (b) continue to support and promote on-line DLESE community services, and (c) work to develop a DLESE ambassadors outreach program involving educators, scientists, and students working across the Earth, space, and environmental sciences. Collaborations with the DLESE Evaluation and Data Centers, collection builders, the DLESE Program Center staff, as well as diverse audience groups will be a key focus of our efforts. We invite you to join us as we work to build and support the next generation of digital services and resources for educators and students at all levels.

  10. Relative Lyapunov Center Bifurcations

    DEFF Research Database (Denmark)

    Wulff, Claudia; Schilder, Frank


    Relative equilibria (REs) and relative periodic orbits (RPOs) are ubiquitous in symmetric Hamiltonian systems and occur, for example, in celestial mechanics, molecular dynamics, and rigid body motion. REs are equilibria, and RPOs are periodic orbits of the symmetry reduced system. Relative Lyapunov...... center bifurcations are bifurcations of RPOs from REs corresponding to Lyapunov center bifurcations of the symmetry reduced dynamics. In this paper we first prove a relative Lyapunov center theorem by combining recent results on the persistence of RPOs in Hamiltonian systems with a symmetric Lyapunov...... center theorem of Montaldi, Roberts, and Stewart. We then develop numerical methods for the detection of relative Lyapunov center bifurcations along branches of RPOs and for their computation. We apply our methods to Lagrangian REs of the N-body problem....

  11. Effects of electrical stimulation of the hunger center in the lateral hypothalamus and food reinforcement on impulse activity of the proper masticatory muscle in rabbits under conditions of hunger and satiation. (United States)

    Ignatova, Ju P; Kromin, A A


    Threshold stimulation of the lateral hypothalamus in starving and preliminary fed (satiated) rabbits in the absence of feed induces searching behavior associated with burst-like impulse activity of proper masticatory muscle with a bimodal distribution of interpulse intervals, what represents an anticipatory type of reaction. The increase in the level of food motivation during threshold stimulation of the lateral hypothalamus in starving and satiated rabbits with the food offered led to successful food-procuring behavior, during which the frequency and amplitude of spike bursts in the proper masticatory muscle become comparable with those under conditions of natural foraging behavior stimulated by the need in nutrients. Motivational excitation and backward afferentation from food reward are addressed to the same neurons of the masticatory center in the medulla oblongata.

  12. CDBG Public Improvements Activity (United States)

    Department of Housing and Urban Development — CDBG activity related to public improvements, including senior centers, youth centers, parks, street improvements, water/sewer improvements, child care centers, fire...

  13. Survival of AIDS patients and characteristics of those who died over eight years of highly active antiretroviral therapy, at a referral center in northeast Brazil

    Directory of Open Access Journals (Sweden)

    Ladjane Santos Wolmer de Melo


    Full Text Available Introduction of highly active antiretroviral therapy has resulted in a significant reduction in morbimortality and significant changes in the causes of death among HIV/AIDS patients. For this reason, it has become essential to monitor survival and causes of death. We constructed a survival curve based on 597 adult patients notified as AIDS cases between 1997 and 2004, at the Hospital das Clínicas, Federal University of Pernambuco, Recife, Brazil. Among those patients, 150 (25% progressed to death by December, 2005. Of these, 119 were studied in detail. The data were collected from notification files of the State Health Department and the State Mortality Information System, and were complemented by analysis of medical records. These 597 patients had a survival rate of 88%, 86% and 82% after one, two and five years, respectively, and a 75% likelihood of surviving to 1,984 days (66 months. Most of the deaths occurred during the first months after the diagnosis (median, 129 days. Patients who died were predominantly young men who had sexual exposure and came from Recife (the state capital or its metropolitan region. When the patients were first seen, a large proportion had already presented severe signs of immunodeficiency. Comparing the patients within this group, the characteristics that were associated with lower survival were: male sex, hemoglobin < 10 mg/dL, lymphocytes < 1,000/mm³, use of fewer therapeutic drugs and antiretroviral regimens and non-introduction of protease inhibitors. Most of them died from AIDS-related diseases, particularly undefined respiratory infections.

  14. Assemblies of a new flexible multicarboxylate ligand and d10 metal centers toward the construction of homochiral helical coordination polymers: structures, luminescence, and NLO-active properties. (United States)

    Zang, Shuangquan; Su, Yang; Li, Yizhi; Ni, Zhaoping; Meng, Qingjin


    Hydro(solvo)thermal reactions between a new flexible multicarboxylate ligand of 2,2',3,3'-oxydiphthalic acid (2,2',3,3'-H(4)ODPA) and M(NO(3))(2).xH(2)O (M = Zn, x = 6; M = Cd, x = 4) in the presence of 4,4'-bipyridine (bpy) afford two novel homochiral helical coordination polymers [[Zn(2)(2,2',3,3'-ODPA)(bpy)(H(2)O)(3)].(H(2)O)(2) for 1 and [Cd(2)(2,2',3,3'-ODPA)(bpy)(H(2)O)(3)].(H(2)O)(2) for 2]. Though having almost the same chemical formula, they have different space groups (P2(1)2(1)2(1) for 1 and P2(1) for 2) and different bridging modes of the 2,2',3,3'-ODPA ligand. Two kinds of homochiral helices (right-handed) are found in both 1 and 2, each of which discriminates only one kind of crystallographical nonequivalent metal atom. 1 has a 2D metal-organic framework and can be seen as the unity of two parallel homochiral Zn1 and Zn2 helices, in which the nodes are etheric oxygen atoms. In contrast, 2 has a 3D metal-organic framework and consists of two partially overlapped homochiral Cd1 and Cd2 helices in the two dimensions. Moreover, metal-ODPA helices give a 2D chiral herringbone structural motif in both 1 and 2 in the two dimensions, which are further strengthened by the second ligand of bpy. Bulk materials for 1 and 2 all have good second-harmonic generation activity, approximately 1 and 0.8 times that of urea.

  15. Experience of the creative Space-Astrophysics Education in Israeli Science-Educational Center "Blossoms of Science" - creative activity from mini-projects in basic school to ASTROTOP-projects for graduates (United States)

    Pustil'Nik, L.; Pundak, D.

    We present 12 year experience of educational project in Space Astrophysics Environment field realized on the base of National Science-Educational Center Blossoms of Science of the Jordan Valley College Our approach is based on the natural curiosity of children as driver of their self-development from the first minutes of their life and even in adult state This approach shift center of the weight in educational process from direct lectures sermons explanation from teacher to children on own attempts of children to investigate problem what is interesting for them by themselves individually or in group Our approach includes four levels of the projects nano-projects for children garden and basic school up to 10-12 years micro-projects for intermediate school 12-16 years mini-projects for high school 16-18 years and macro-projects for the best graduates high schools and students of colleges 17-22 years These levels and projects are interconnected one with another and sometimes participants started on the micro-projects level in intermediate school continue their activity up to macro-projects of the graduate s diploma level For each level we organize courses for preparation of the teachers and instructors interested in the using of our receipts and published books and brochures for them The content of our activity for different levels a Level of kinder gardens-basic schools -- special software with interactive movie - - nano-projects b Level of intermediate school Days of Science in tens schools of Israel--

  16. Energy efficient data centers

    Energy Technology Data Exchange (ETDEWEB)

    Tschudi, William; Xu, Tengfang; Sartor, Dale; Koomey, Jon; Nordman, Bruce; Sezgen, Osman


    Data Center facilities, prevalent in many industries and institutions are essential to California's economy. Energy intensive data centers are crucial to California's industries, and many other institutions (such as universities) in the state, and they play an important role in the constantly evolving communications industry. To better understand the impact of the energy requirements and energy efficiency improvement potential in these facilities, the California Energy Commission's PIER Industrial Program initiated this project with two primary focus areas: First, to characterize current data center electricity use; and secondly, to develop a research ''roadmap'' defining and prioritizing possible future public interest research and deployment efforts that would improve energy efficiency. Although there are many opinions concerning the energy intensity of data centers and the aggregate effect on California's electrical power systems, there is very little publicly available information. Through this project, actual energy consumption at its end use was measured in a number of data centers. This benchmark data was documented in case study reports, along with site-specific energy efficiency recommendations. Additionally, other data center energy benchmarks were obtained through synergistic projects, prior PG&E studies, and industry contacts. In total, energy benchmarks for sixteen data centers were obtained. For this project, a broad definition of ''data center'' was adopted which included internet hosting, corporate, institutional, governmental, educational and other miscellaneous data centers. Typically these facilities require specialized infrastructure to provide high quality power and cooling for IT equipment. All of these data center types were considered in the development of an estimate of the total power consumption in California. Finally, a research ''roadmap'' was developed

  17. Treatment of bleeding in acquired hemophilia A with the proper administration of recombinant activated factor VII: single-center study of 7 cases (United States)

    Saito, Makoto; Kanaya, Minoru; Izumiyama, Koh; Mori, Akio; Irie, Tatsuro; Tanaka, Masanori; Morioka, Masanobu; Ieko, Masahiro


    Recombinant activated factor VII (rFVIIa) is the bypassing agent used in the first-line hemostatic therapy for acquired hemophilia A (AHA); however, the occurrence of thrombotic complications in rFVIIa-treated AHA patients was recently reported to be 2.9–6.5%. Therefore, the investigation of the proper administration of rFVIIa for AHA is needed. In the present study, we retrospectively investigated the clinical features of AHA with regards to the use of rFVIIa (presence or absence of use and total amount) in 7 AHA patients encountered in our department for 7 years between January 2008 and December 2014. Ages were 63–89 years old (median: 79 years old), and there were 5 male and 2 female patients. The coexistence of cardiovascular risk factors and arteriosclerotic diseases, such as hypertension, diabetes mellitus, and cerebral infarction were present in 6 patients. Anemia progressed to less than 7 g/dL of hemoglobin and required red blood cell transfusion in 5 patients, showing “severe” hemorrhage. Factor VIII inhibitors were removed by immunological treatments in 6 patients. As a hemostatic therapy, rFVIIa was used in 4 patients. rFVIIa was not administered or was administered at a very low dose (20 mg) to 3 and 1 patient, respectively, and bleeding stopped as inhibitor titers decreased and disappeared in these patients. Inhibitors did not disappear in 1 patient and the control of hemostasis became poor and was accompanied by intestinal hemorrhage. Although a large amount of rFVIIa (265 mg in total) was administered, the patient bled to death. Therefore, bleeding may be stopped without the administration of rFVIIa in some AHA cases, while the dose of rFVIIa is not necessarily related to hemostatic effects in other cases. Since the main aim of AHA treatments is the removal of inhibitors, caution is needed to ensure that more than the necessary amount of rFVIIa is not administered. PMID:27843336

  18. National Automotive Center - NAC (United States)

    Federal Laboratory Consortium — Encouraged by the advantages of collaboration, the U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC) worked with the Secretary of the...

  19. Test Control Center (United States)


    At the test observation periscope in the Test Control Center exhibit in StenniSphere at the John C. Stennis Space Center in Hancock County, Miss., visitors can observe a test of a Space Shuttle Main Engine exactly as test engineers might see it during a real engine test. The Test Control Center exhibit exactly simulates not only the test control environment, but also the procedure of testing a rocket engine. Designed to entertain while educating, StenniSphere includes informative dispays and exhibits from NASA's lead center for rocket propulsion and remote sensing applications. StenniSphere is open free of charge from 9 a.m. to 5 p.m. daily.

  20. Cooperative Tagging Center (CTC) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Cooperative Tagging Center (CTC) began as the Cooperative Game Fish Tagging Program (GTP) at Woods Hole Oceanographic Institute (WHOI) in 1954. The GTP was...

  1. NMA Analysis Center (United States)

    Kierulf, Halfdan Pascal; Andersen, Per Helge


    The Norwegian Mapping Authority (NMA) has during the last few years had a close cooperation with Norwegian Defence Research Establishment (FFI) in the analysis of space geodetic data using the GEOSAT software. In 2012 NMA has taken over the full responsibility for the GEOSAT software. This implies that FFI stopped being an IVS Associate Analysis Center in 2012. NMA has been an IVS Associate Analysis Center since 28 October 2010. NMA's contributions to the IVS as an Analysis Centers focus primarily on routine production of session-by-session unconstrained and consistent normal equations by GEOSAT as input to the IVS combined solution. After the recent improvements, we expect that VLBI results produced with GEOSAT will be consistent with results from the other VLBI Analysis Centers to a satisfactory level.

  2. Center for Contaminated Sediments (United States)

    Federal Laboratory Consortium — The U.S. Army Corps of Engineers Center for Contaminated Sediments serves as a clearinghouse for technology and expertise concerned with contaminated sediments. The...

  3. Reliability Centered Maintenance - Methodologies (United States)

    Kammerer, Catherine C.


    Journal article about Reliability Centered Maintenance (RCM) methodologies used by United Space Alliance, LLC (USA) in support of the Space Shuttle Program at Kennedy Space Center. The USA Reliability Centered Maintenance program differs from traditional RCM programs because various methodologies are utilized to take advantage of their respective strengths for each application. Based on operational experience, USA has customized the traditional RCM methodology into a streamlined lean logic path and has implemented the use of statistical tools to drive the process. USA RCM has integrated many of the L6S tools into both RCM methodologies. The tools utilized in the Measure, Analyze, and Improve phases of a Lean Six Sigma project lend themselves to application in the RCM process. All USA RCM methodologies meet the requirements defined in SAE JA 1011, Evaluation Criteria for Reliability-Centered Maintenance (RCM) Processes. The proposed article explores these methodologies.

  4. The ORFEUS Data Center

    Directory of Open Access Journals (Sweden)

    B. Dost


    Full Text Available 1993 the ORFEUS Data Center (ODC; Dost, 1991 changed hosting organisation. It moved within the Netherlands from the University of Utrecht to the Royal Netherlands Meteorological Institute (KNM1 in de Bilt. This change in hosting organisation was necessary to ensure a longer term stability in the operation of the ODC. Key issues for the ODC are the rapid on-line data access and quality controlled, complete and efficient off-line data access. During 1992 the ODC became the European node in the international SPYDER system which provides near real-time access to digital broadband data from selected high quality stations. Electronic messages trigger soveral centers well distributed over the globe. These centers then collect the data by modem from selected stations in their region. Finally, data are distributed between data centers over internet.

  5. Advanced data center economy


    Sukhov, R.; Amzarakov, M.; E. Isaev


    The article addresses basic Data Centers (DC) drivers of price and engineering, which specify rules and price evaluation for creation and further operation. DC energy efficiency concept, its influence on DC initial price, operation costs and Total Cost of Ownership.

  6. Global Hydrology Research Center (United States)

    National Aeronautics and Space Administration — The GHRC is the data management and user services arm of the Global Hydrology and Climate Center. It encompasses the data and information management, supporting...

  7. National Farm Medicine Center (United States)

    Research Areas Applied Sciences Biomedical Informatics Clinical Research Epidemiology Farm Medicine Human Genetics Oral-Systemic Health Clinical ... Consulting Agritourism Farm MAPPER Lyme Disease ROPS Rebate Zika Virus National Farm Medicine Center The National Farm ...

  8. Hazardous Waste Research Center (United States)

    Federal Laboratory Consortium — A full-service research and evaluation center equipped with safety equipment, a high-bay pilot studies area, and a large-scale pilot studies facility The U.S. Army...

  9. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Community Outreach Resource Center Toy Recall Statistics CO Poster Contest Pool Safely Business & Manufacturing Business & Manufacturing Business ... Featured Resources CPSC announces winners of carbon monoxide poster contest Video View the blog Clues You Can ...

  10. World Trade Center

    Index Scriptorium Estoniae


    Esilinastus katastroofifilm "World Trade Center" : stsenarist Andrea Berloff : režissöör Oliver Stone : kunstnik Jan Roelfs : osades Nicholas Cage, Michael Pena, Stephen Dorff jpt : Ameerika Ühendriigid 2006. Ka filmi prototüüpidest

  11. Health Center Controlled Network (United States)

    U.S. Department of Health & Human Services — The Health Center Controlled Network (HCCN) tool is a locator tool designed to make data and information concerning HCCN resources more easily available to our...

  12. USU Patient Simulation Center (United States)

    Federal Laboratory Consortium — he National Capital Area (NCA) Medical Simulation Center is a state-of-the-art training facility located near the main USU campus. It uses simulated patients (i.e.,...

  13. HUD Homeownership Centers (United States)

    Department of Housing and Urban Development — HUD Homeownership Centers (HOCs) insure single family Federal Housing Administration (FHA) mortgages and oversee the selling of HUD homes. FHA has four Homeownership...

  14. Mental Health Screening Center (United States)

    ... Releases & Announcements Public Service Announcements Partnering with DBSA Mental Health Screening Center These online screening tools are not ... you have any concerns, see your doctor or mental health professional. Depression This screening form was developed from ...

  15. FEMA Disaster Recovery Centers (United States)

    Department of Homeland Security — This is a search site for FEMA's Disaster Recovery Centers (DRC). A DRC is a readily accessible facility or mobile office set up by FEMA where applicants may go for...

  16. Centering in Japanese Discourse

    CERN Document Server

    Walker, M; Côté, S; Walker, Marilyn; Iida, Masayo; Cote, Sharon


    In this paper we propose a computational treatment of the resolution of zero pronouns in Japanese discourse, using an adaptation of the centering algorithm. We are able to factor language-specific dependencies into one parameter of the centering algorithm. Previous analyses have stipulated that a zero pronoun and its cospecifier must share a grammatical function property such as {\\sc Subject} or {\\sc NonSubject}. We show that this property-sharing stipulation is unneeded. In addition we propose the notion of {\\sc topic ambiguity} within the centering framework, which predicts some ambiguities that occur in Japanese discourse. This analysis has implications for the design of language-independent discourse modules for Natural Language systems. The centering algorithm has been implemented in an HPSG Natural Language system with both English and Japanese grammars.

  17. Accredited Birth Centers (United States)

    ... 9743 Accredited since January 2016 98 Bright Eyes Midwifery and Wild Rivers Women's Health Accredited 29135 Ellensburg ... Accredited since November 2015 96 Footprints in Time Midwifery Services and Birth Center Accredited 351 N. Water ...

  18. Advanced Missile Signature Center (United States)

    Federal Laboratory Consortium — The Advanced Missile Signature Center (AMSC) is a national facility supporting the Missile Defense Agency (MDA) and other DoD programs and customers with analysis,...

  19. Understanding wellness center loyalty through lifestyle analysis. (United States)

    Suresh, Satya; Ravichandran, Swathi; P, Ganesan


    Many changes taking place at a macro-level in Indian society along with the popularity of services that are native to India, such as Yoga and Ayurveda, have generated significant interest in wellness services. To assist wellness centers in gaining loyal clients, the goal of this study was to understand the influence of customer lifestyle factors on wellness center loyalty. The activities, interests, and opinions model was used to understand the lifestyles of wellness center clients. Data were collected from clients of five wellness centers. Regression results indicate that overworked individuals and those seeking a balance between work and family life would be the most loyal to wellness centers. Managerial implications of results are discussed.

  20. Oil Reserve Center Established

    Institute of Scientific and Technical Information of China (English)


    Like other countries,China has started to grow its strategic oil reserve in case oil supplies are cut On December 18,2007,the National Development and Reform Commission(NDRC),China’s top economic planner,announced that the national oil reserve center has been officially launched.The supervisory system over the oil reserves has three levels: the energy department of the NDRC,the oil reserve center,and the reserve bases.

  1. Data center cooling system

    Energy Technology Data Exchange (ETDEWEB)

    Chainer, Timothy J; Dang, Hien P; Parida, Pritish R; Schultz, Mark D; Sharma, Arun


    A data center cooling system may include heat transfer equipment to cool a liquid coolant without vapor compression refrigeration, and the liquid coolant is used on a liquid cooled information technology equipment rack housed in the data center. The system may also include a controller-apparatus to regulate the liquid coolant flow to the liquid cooled information technology equipment rack through a range of liquid coolant flow values based upon information technology equipment temperature thresholds.

  2. National Biocontainment Training Center (United States)


    than ever before as scientists push to understand the pathology and develop diagnostics, vaccines and therapeutics for deadly diseases like Ebola...Hardcastle, Vickie Jones, Sheri Leavitt, and Belinda Rivera. Gulf Coast Consortium Postdoctoral Veterinary Training Program - A clinical veterinarian from...the Center for Comparative Medicine at Baylor College of Medicine in Houston and a veterinarian from the University of Texas Health Science Center

  3. Examination of center of pressure displacement and muscle activity of the hip girdle muscles on lateral movement in the sitting position, focusing on kinematic features before and after the start of exercise (United States)

    Ikeda, Kouji; Suehiro, Kenji; Kizu, Akito; Kunieda, Hideki; Takasaki, Hirokazu; Suzuki, Toshiaki


    [Purpose] This study aimed to evaluate the kinematic characteristics at the start of lateral movement in the sitting position, for application in physical therapy. [Subjects and Methods] Eleven healthy male subjects (mean age, 24.8 ± 3.7 years) were included in the study after they provided informed consent. The electromyographic activities of the tensor fascia lata, gluteus medius, and rectus femoris, and the center of pressure (COP) displacement during lateral reach in the sitting position were measured. The task was recorded on video for analysis. [Results] In almost all subjects, before the beginning of the task, the electromyographic activity in the opposite side of each studied muscle was recorded, and the opposite and anterior displacement of the COP was observed. The video analysis revealed that all subjects showed lateral displacement of the thoracic part of the trunk after the start of the task. However, the lumbar region and pelvis maintained their starting positions. [Conclusion] COP displacement occurred in the reverse reaction before the task, and this involved the hip girdle muscles of the opposite side. A reverse reaction displaced the pelvis to the opposite side to ensure instability of posture through side tilting of the trunk at the beginning of the task. PMID:28356627

  4. 77 FR 12845 - Centers for Disease Control and Prevention (CDC) (United States)


    ... HUMAN SERVICES Centers for Disease Control and Prevention (CDC) Disease, Disability, and Injury... Centers for Disease Control and Prevention/Agency for Toxic Substances and Disease Registry (CDC/ATSDR... meetings and other committee management activities, for both the Centers for Disease Control and...

  5. SHAO Analysis Center 2012 Annual Report (United States)

    Wang, Guangli; Li, Jinling; Xu, Minghui; Guo, Li; Liu, Li; Shu, Fengchun; Qian, Zhihan; Li, Liang


    The Shanghai Astronomical Observatory (SHAO) Analysis Center in 2012 continued routine VLBI data analysis and produced earth orientation parameter (EOP), terrestrial reference frame (TRF), and celestial reference frame (CRF) information, which was submitted to the IVS quarterly. The activities of SHAO also consisted of data reduction of the Chinese VLBI Network (CVN), spacecraft navigation using the VLBI technique, and some research activities.

  6. Active Center of Islamic Dialogue Civilizations

    Directory of Open Access Journals (Sweden)

    Ebrahim Moghimi


    Full Text Available It is obvious that an essay have introduced about Dialogue Civilizations, at first must be start with a definition about it. Obviously, this simple definition is almost difficult. Defining of Dialogue Civilizations is complex and difficult as far as it need to a vast range of definitions. In this essay will argue that how ever definition of Dialogue Civilization is different, can only seek as specific of intemporall and special situations that are in real-life. As well as this essay emphasize to practice of environmental (realm in Islamic countries. The philosophy of this essay is that, what is the share of Islamic environments with regard to looking at Civilizations special phenomena. The first attitude is that Islamic civilization includes different spaces around the globe. The second attitude is that Islamic Civilization includes developing of other Civilizations realm. The third is that in the realm of Islamic Civilization live different human life and this is an important starting point for Cultural Dialogue in the Islamic countries together. The fourth is that, there are expanding (space, population, political systems, organs and economic is different, that we will describe them in this essay.

  7. Human Centered Hardware Modeling and Collaboration (United States)

    Stambolian Damon; Lawrence, Brad; Stelges, Katrine; Henderson, Gena


    In order to collaborate engineering designs among NASA Centers and customers, to in clude hardware and human activities from multiple remote locations, live human-centered modeling and collaboration across several sites has been successfully facilitated by Kennedy Space Center. The focus of this paper includes innovative a pproaches to engineering design analyses and training, along with research being conducted to apply new technologies for tracking, immersing, and evaluating humans as well as rocket, vehic le, component, or faci lity hardware utilizing high resolution cameras, motion tracking, ergonomic analysis, biomedical monitoring, wor k instruction integration, head-mounted displays, and other innovative human-system integration modeling, simulation, and collaboration applications.

  8. [Theater in Brazilian science museums and centers]. (United States)

    Moreira, Leonardo Maciel; Marandino, Martha


    This qualitative research, based on a descriptive and exploratory study, examines how theater is used as a science communication strategy by Brazilian science museums and centers. Data was collected through a survey emailed to 24 Brazilian institutions identified as science museums and centers. Content analysis was performed, using cross-sectional thematic analysis. It was found that respondents' activities could be classified as approaching theater as an educational support.

  9. Microsoft System Center 2012 Orchestrator cookbook

    CERN Document Server

    Erskine, Samuel


    This book is written in a practical, Cookbook style with numerous chapters and recipes focusing on creating runbooks to automate mission critical and everyday administration tasks.System Center 2012 Orchestrator is for administrators who wish to simplify the process of automating systems administration tasks. This book assumes that you have a basic knowledge of Windows Server 2008 Administration, Active Directory, Network Systems, and Microsoft System Center technologies.

  10. Engineer Research and Development Center's Materials Testing Center (MTC) (United States)

    Federal Laboratory Consortium — The Engineer Research and Development Center's Materials Testing Center (MTC) is committed to quality testing and inspection services that are delivered on time and...

  11. Air Risk Information Support Center

    Energy Technology Data Exchange (ETDEWEB)

    Shoaf, C.R.; Guth, D.J. [Environmental Protection Agency, Washington, DC (United States)


    The Air Risk Information Support Center (Air RISC) was initiated in early 1988 by the US Environmental Protection Agency`s (EPA) Office of Health and Environmental Assessment (OHEA) and the Office of Air Quality Planning and Standards (OAQPS) as a technology transfer effort that would focus on providing information to state and local environmental agencies and to EPA Regional Offices in the areas of health, risk, and exposure assessment for toxic air pollutants. Technical information is fostered and disseminated by Air RISCs three primary activities: (1) a {open_quotes}hotline{close_quotes}, (2) quick turn-around technical assistance projects, and (3) general technical guidance projects. 1 ref., 2 figs.

  12. Hospitals report on cancer centers. (United States)

    Rees, T


    Woman's Hospital, Baton Rouge, La., is first-place winner among cancer centers. Holy Cross Hospital's Michael and Dianne Bienes Comprehensive Cancer Center, Ft. Lauderdale, Fla., is named second; and, Cardinal Health System's Ball Cancer Center, Muncie, Ind., third.

  13. NASA InterCenter Collaboration Increases ROI (United States)

    Lankford, Kimberly; Best, Susan; Felton, Larry; Newhouse, Marilyn


    Funding for National Aeronautics and Space Administration (NASA) space mission operations is tighter than ever in the current environment of federal government deficit reductions. Conventional wisdom would expect this environment to drive increasing competition between NASA centers for the limited available funds. However, recent inter-center activities at the Huntsville Operations Support Center (HOSC) at NASA's Marshall Space Flight Center emphasize collaboration rather than competition and demonstrate the value of partnerships to increase the return on shrinking investments. These efforts cover a variety of activities and potential returns. To facilitate sharing data from test and verification through operations without levying requirements on data format or software tools, the HOSC is working with multiple centers on an evolutionary path toward a distributed data architecture and archive. The approach reduces the required investment by allowing the partners to reuse their existing formats and tools, while facilitating gone ]stop h user visibility into and controlled access to the full complement of data regardless of user or data location. The HOSC is also working on two activities to promote sharing operations implementations and leveraging the experts and expertise across multiple NASA sites. In one, the use of Consultative Committee for Space Data Systems (CCSDS) standards for the message abstraction layer provides an interoperability layer on top of existing ground data system communication architectures. This allows missions to select the most appropriate solutions for their requirements with a minimal investment in rehosting the components in a coherent operational environment. The other emphasizes shared tools and increased remote access to minimize travel for tests and critical activities and reduce the floor space required for a dedicated operations center. This paper summarizes these and other inter-center collaboration activities at the HOSC and the

  14. International Water Center (United States)

    The urban district of Nancy and the Town of Nancy, France, have taken the initiative of creating an International Center of Water (Centre International de l'Eau à Nancy—NAN.C.I.E.) in association with two universities, six engineering colleges, the Research Centers of Nancy, the Rhine-Meuse Basin Agency, and the Chamber of Commerce and Industry. The aim of this center is to promote research and technology transfer in the areas of water and sanitation. In 1985 it will initiate a research program drawing on the experience of 350 researchers and engineers of various disciplines who have already been assigned to research in these fields. The research themes, the majority of which will be multidisciplinary, concern aspects of hygiene and health, the engineering of industrial processes, water resources, and the environment and agriculture. A specialist training program offering five types of training aimed at university graduates, graduates of engineering colleges, or experts, will start in October 1984.

  15. Lied Transplant Center

    Energy Technology Data Exchange (ETDEWEB)



    The Department of Energy has prepared an Environmental Assessment (DOE/EA-1143) evaluating the construction, equipping and operation of the proposed Lied Transplant Center at the University of Nebraska Medical Center in Omaha, Nebraska. Based on the analysis in the EA, the DOE has determined that the proposed action does not constitute a major federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act of 1969 (NEPA). Therefore, the preparation of an Environmental Statement in not required.

  16. Data Center Energy Retrofits


    PervilÀ, Mikko


    Within the field of computer science, data centers (DCs) are a major consumer of energy. A large part of that energy is used for cooling down the exhaust heat of the servers contained in the DCs. This thesis describes both the aggregate numbers of DCs and key flagship installations in detail. We then introduce the concept of Data Center Energy Retrofits, a set of low cost, easy to install techniques that may be used by the majority of DCs for reducing their energy consumption. The main c...

  17. User Centered Design

    DEFF Research Database (Denmark)

    Egbert, Maria; Matthews, Ben


    The interdisciplinary approach of User Centered Design is presented here with a focus on innovation in the design and use of hearing technologies as well as on the potential of innovation in interaction. This approach is geared towards developing new products, systems, technologies and practices...... based on an understanding of why so few persons with hearing loss use the highly advanced hearing technologies. In integrating Conversation Analysis (“CA”), audiology and User Centered Design, three disciplines which are collaborating together for the first time, we are addressing the following...


    Energy Technology Data Exchange (ETDEWEB)



    It is well known that beam position monitors (BPM) utilizing signals from pickup electrodes (PUE) provide good resolution and relative accuracy. The absolute accuracy (i.e. position of the orbit in the vacuum chamber) is not very good due to the various reasons. To overcome the limitation it was suggested to use magnetic centers of quadrupoles for the calibration of the BPM [1]. The proposed method provides accuracy better then 200 microns for centering of the beam position monitors using modulation of the whole quadrupole family.

  19. Xichang Satellite Launch Center

    Institute of Scientific and Technical Information of China (English)



    Xichang Satellite Launch Center(XSLC) is mainly for geosynchronous orbit launches. The main purpose of XSLC is to launch spacecraft, such as broadcasting,communications and meteorological satellites, into geo-stationary orbit.Most of the commercial satellite launches of Long March vehicles have been from Xichang Satellite Launch Center. With 20 years' development,XSLC can launch 5 kinds of launch vehicles and send satellites into geostationary orbit and polar orbit. In the future, moon exploration satellites will also be launched from XSLC.

  20. Center for Botanical Interaction Studies (United States)

    Federal Laboratory Consortium — Research Area: Dietary Supplements, Herbs, Antioxidants Program:Centers for Dietary Supplements Research: Botanicals Description:This center will look at safety and...

  1. Data Analysis and Assessment Center (United States)

    Federal Laboratory Consortium — The DoD Supercomputing Resource Center (DSRC) Data Analysis and Assessment Center (DAAC) provides classified facilities to enhance customer interactions with the ARL...

  2. When teacher-centered instructors are assigned to student-centered classrooms (United States)

    Lasry, Nathaniel; Charles, Elizabeth; Whittaker, Chris


    Technology-rich student-centered classrooms such as SCALE-UP and TEAL are designed to actively engage students. We examine what happens when the design of the classroom (conventional or teacher-centered versus student-centered classroom spaces) is consistent or inconsistent with the teacher's epistemic beliefs about learning and teaching (traditional or teacher-centered versus student-centered pedagogies). We compare two types of pedagogical approaches and two types of classroom settings through a quasiexperimental 2×2 factorial design. We collected data from 214 students registered in eight sections of an introductory calculus-based mechanics course given at a Canadian publicly funded two-year college. All students were given the Force Concept Inventory at the beginning and at the end of the 15-week-long course. We then focused on six teachers assigned to teach in the student-centered classroom spaces. We used qualitative observations and the Approaches to Teaching Inventory (ATI), a self-reported questionnaire, to determine the teachers' epistemic beliefs (teacher-centered or student-centered) and how these beliefs affected their use of the space and their students' conceptual learning. We report four main findings. First, the student-centered classroom spaces are most effective when used with student-centered pedagogies. Second, student-centered classrooms are ineffective when used with teacher-centered pedagogies and may have negative effects for students with low prior knowledge. Third, we find a strong correlation between six instructors' self-reported epistemic beliefs of student centeredness and their classes' average normalized gain (r =0.91; p =0.012). Last, we find that some instructors are more willing to adopt student-centered teaching practices after using student-centered classroom spaces. These data suggest that student-centered classrooms are effective only when instructors' epistemic framework of teaching and learning is consistent with a student-centered

  3. Operating and Managing a Backup Control Center (United States)

    Marsh, Angela L.; Pirani, Joseph L.; Bornas, Nicholas


    Due to the criticality of continuous mission operations, some control centers must plan for alternate locations in the event an emergency shuts down the primary control center. Johnson Space Center (JSC) in Houston, Texas is the Mission Control Center (MCC) for the International Space Station (ISS). Due to Houston s proximity to the Gulf of Mexico, JSC is prone to threats from hurricanes which could cause flooding, wind damage, and electrical outages to the buildings supporting the MCC. Marshall Space Flight Center (MSFC) has the capability to be the Backup Control Center for the ISS if the situation is needed. While the MSFC Huntsville Operations Support Center (HOSC) does house the BCC, the prime customer and operator of the ISS is still the JSC flight operations team. To satisfy the customer and maintain continuous mission operations, the BCC has critical infrastructure that hosts ISS ground systems and flight operations equipment that mirrors the prime mission control facility. However, a complete duplicate of Mission Control Center in another remote location is very expensive to recreate. The HOSC has infrastructure and services that MCC utilized for its backup control center to reduce the costs of a somewhat redundant service. While labor talents are equivalent, experiences are not. Certain operations are maintained in a redundant mode, while others are simply maintained as single string with adequate sparing levels of equipment. Personnel at the BCC facility must be trained and certified to an adequate level on primary MCC systems. Negotiations with the customer were done to match requirements with existing capabilities, and to prioritize resources for appropriate level of service. Because some of these systems are shared, an activation of the backup control center will cause a suspension of scheduled HOSC activities that may share resources needed by the BCC. For example, the MCC is monitoring a hurricane in the Gulf of Mexico. As the threat to MCC

  4. User-Centered Design through Learner-Centered Instruction (United States)

    Altay, Burçak


    This article initially demonstrates the parallels between the learner-centered approach in education and the user-centered approach in design disciplines. Afterward, a course on human factors that applies learner-centered methods to teach user-centered design is introduced. The focus is on three tasks to identify the application of theoretical and…

  5. Economics of data center optics (United States)

    Huff, Lisa


    Traffic to and from data centers is now reaching Zettabytes/year. Even the smallest of businesses now rely on data centers for revenue generation. And, the largest data centers today are orders of magnitude larger than the supercomputing centers of a few years ago. Until quite recently, for most data center managers, optical data centers were nice to dream about, but not really essential. Today, the all-optical data center - perhaps even an all-single mode fiber (SMF) data center is something that even managers of medium-sized data centers should be considering. Economical transceivers are the key to increased adoption of data center optics. An analysis of current and near future data center optics economics will be discussed in this paper.

  6. vCenter troubleshooting

    CERN Document Server

    Mills, Chuck


    The book is designed for the competent vCenter administrator or anyone who is responsible for the vSphere environment. It can be used as a guide by vSphere architects and VMware consultants for a successful vSphere solution. You should have good knowledge and an understanding of core elements and applications of the vSphere environment.

  7. Mobile PET Center Project (United States)

    Ryzhikova, O.; Naumov, N.; Sergienko, V.; Kostylev, V.


    Positron emission tomography is the most promising technology to monitor cancer and heart disease treatment. Stationary PET center requires substantial financial resources and time for construction and equipping. The developed mobile solution will allow introducing PET technology quickly without major investments.

  8. Data Center Site Redundancy


    Brotherton, H M; Dietz, J. Eric


    Commonly, disaster contingency calls for separation of location for redundant locations to maintain the needed redundancy. This document addresses issues for the data center redundancy, including limits to the distribution, distance and location that may impact on the efficiency or energy.

  9. Alternative Fuels Data Center

    Energy Technology Data Exchange (ETDEWEB)



    Fact sheet describes the Alternative Fuels Data Center, which provides information, data, and tools to help fleets and other transportation decision makers find ways to reduce petroleum consumption through the use of alternative and renewable fuels, advanced vehicles, and other fuel-saving measures.

  10. School Based Health Centers (United States)

    Children's Aid Society, 2012


    School Based Health Centers (SBHC) are considered by experts as one of the most effective and efficient ways to provide preventive health care to children. Few programs are as successful in delivering health care to children at no cost to the patient, and where they are: in school. For many underserved children, The Children's Aid Society's…

  11. Carolinas Energy Career Center

    Energy Technology Data Exchange (ETDEWEB)

    Classens, Anver; Hooper, Dick; Johnson, Bruce


    Central Piedmont Community College (CPCC), located in Charlotte, North Carolina, established the Carolinas Energy Career Center (Center) - a comprehensive training entity to meet the dynamic needs of the Charlotte region's energy workforce. The Center provides training for high-demand careers in both conventional energy (fossil) and renewable energy (nuclear and solar technologies/energy efficiency). CPCC completed four tasks that will position the Center as a leading resource for energy career training in the Southeast: • Development and Pilot of a New Advanced Welding Curriculum, • Program Enhancement of Non-Destructive Examination (NDE) Technology, • Student Support through implementation of a model targeted toward Energy and STEM Careers to support student learning, • Project Management and Reporting. As a result of DOE funding support, CPCC achieved the following outcomes: • Increased capacity to serve and train students in emerging energy industry careers; • Developed new courses and curricula to support emerging energy industry careers; • Established new training/laboratory resources; • Generated a pool of highly qualified, technically skilled workers to support the growing energy industry sector.

  12. Starting a sleep center. (United States)

    Epstein, Lawrence J; Valentine, Paul S


    The demand for sleep medicine services has grown tremendously during the last decade and will likely continue. To date, growth in demand has been met by growth in the number of new sleep centers. The need for more new centers will be dependent on market drivers that include increasing regulatory requirements, personnel shortages, integration of home sleep testing, changes in reimbursement, a shift in emphasis from diagnostics to treatment, and an increased consumer focus on sleep. The decision to open a new center should be based on understanding the market dynamics, completing a market analysis, and developing a business plan. The business plan should include an overview of the facility, a personnel and organizational structure, an evaluation of the business environment, a financial plan, a description of services provided, and a strategy for obtaining, managing, and extending a referral base. Implementation of the business plan and successful operation require ongoing planning and monitoring of operational parameters. The need for new sleep centers will likely continue, but the shifting market dynamics indicate a greater need for understanding the marketplace and careful planning.

  13. Memorial Alexander Center

    Directory of Open Access Journals (Sweden)

    AECK Associates, Arquitectos


    Full Text Available En Atlanta, el Instituto Tecnológico de Georgia acaba de ampliar sus instalaciones deportivas, construyendo el Alexander Memorial Center. Consta este nuevo Centro de dos edificios: una pista de baloncesto cubierta y un edificio anejo con vestuarios, duchas, una pista de entrenamiento, equipos técnicos y la emisora de radio Georgia Tech W. G. S. T.

  14. Graduate Automotive Technology Education (GATE) Center

    Energy Technology Data Exchange (ETDEWEB)

    Jeffrey Hodgson; David Irick


    The Graduate Automotive Technology Education (GATE) Center at the University of Tennessee, Knoxville has completed its sixth year of operation. During this period the Center has involved thirteen GATE Fellows and ten GATE Research Assistants in preparing them to contribute to advanced automotive technologies in the center's focus area: hybrid drive trains and control systems. Eighteen GATE students have graduated, and three have completed their course work requirements. Nine faculty members from three departments in the College of Engineering have been involved in the GATE Center. In addition to the impact that the Center has had on the students and faculty involved, the presence of the center has led to the acquisition of resources that probably would not have been obtained if the GATE Center had not existed. Significant industry interaction such as internships, equipment donations, and support for GATE students has been realized. The value of the total resources brought to the university (including related research contracts) exceeds $4,000,000. Problem areas are discussed in the hope that future activities may benefit from the operation of the current program.

  15. Center for beam physics 1996-1997

    Energy Technology Data Exchange (ETDEWEB)



    The Center for Beam Physics (CBP) is a multidisciplinary research and development unit in the Accelerator and Fusion Research Division at the Ernest Orlando Lawrence Berkeley National Laboratory of the University of California. At the heart of the Center`s mission is the fundamental quest for mechanisms of acceleration, radiation, transport, and focusing of energy and information. Special features of the Center`s program include addressing R&D issues needing long development time and providing a platform for conception, initiation, and support of institutional projects based on beams. The Center brings to bear a significant amount of diverse, complementary, and self-sufficient expertise in accelerator physics, synchrotron radiation, advanced microwave techniques, plasma physics, optics, and lasers on the forefront R&D issues in particle and photon beam research. In addition to functioning as a clearinghouse for novel ideas and concepts and related R&D (e.g., various theoretical and experimental studies in beam physics such as nonlinear dynamics, phase space control, laser-beam-plasma interaction, free-electron lasers, optics, and instrumentation), the Center provides significant support to Laboratory facilities and initiatives. This roster and annual report provides a glimpse of the scientists, engineers, technical support, students, and administrative staff that make up the CBP`s outstanding team and gives a flavor of their multifaceted activities during 1996 and 1997.

  16. EERC Center for Biomass Utilization 2006

    Energy Technology Data Exchange (ETDEWEB)

    Zygarlicke, Christopher J. [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center; Hurley, John P. [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center; Aulich, Ted R. [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center; Folkedahl, Bruce C. [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center; Strege, Joshua R. [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center; Patel, Nikhil [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center; Shockey, Richard E. [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center


    The Center for Biomass Utilization® 2006 project at the Energy & Environmental Research Center (EERC) consisted of three tasks related to applied fundamental research focused on converting biomass feedstocks to energy, liquid transportation fuels, and chemicals. Task 1, entitled Thermochemical Conversion of Biomass to Syngas and Chemical Feedstocks, involved three activities. Task 2, entitled Crop Oil Biorefinery Process Development, involved four activities. Task 3, entitled Management, Education, and Outreach, focused on overall project management and providing educational outreach related to biomass technologies through workshops and conferences.


    Directory of Open Access Journals (Sweden)



    Full Text Available The financial performance of a responsibility center is measured on the basis of specific indicators of the nature center. To obtain a relevant and consistent images relating to the performance of an entity is required to use a system of indicators. Performance indicators of the structure it needs to capture at the same time, at least the following aspects: the objectives of the entity, its strategy, efficacy and effectiveness of activities carried out, the entity's ability to adapt to the requirements of the market in which they operate. Financial indicators of performance are the most objective, because most businesses give important resources for the activities of audit and control.

  18. Assessment of adherence to highly active antiretroviral therapy and associated factors among people living with HIV at Debrebrihan Referral Hospital and Health Center, Northeast Ethiopia: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Ketema AK


    Full Text Available Abush Kebede Ketema,1 Zewdu Shewangizaw Weret21Regional Monitoring and Evaluation Advisor, Management Sciences for Health, Addis Ababa, Ethiopia; 2College of Medicine and Health Sciences, Arbaminch University, Arbaminch, EthiopiaAbstract: Patient adherence to antiretroviral combination therapy is a critical component to successful treatment outcome. Nonadherence to antiretroviral therapy (ART is a major challenge to AIDS care, and the risks associated with it are extensive. The intention of this study was to determine prevalence and associated factors with adherence to highly active ART among people living with HIV/AIDS (PLWHA at the Debrebrihan Referral Hospital and Health Center, Northeast Ethiopia. A cross-sectional study design with systematic random sampling conducted by the use of a structured, pretested self-rating adherence questionnaire was used to conduct the study among 422 respondents from the Debrebrihan Referral Hospital and Health Center. A single population proportion formula at 95% CI with 5% of marginal error at 50% of prevalence of occurrence was used to determine sample size. Adherence was defined as not missing a single ART dose during the 30-day period prior to filling out the self-report. Adherence was measured by self-reports by the patients. These results were then used in binary logistic regression analysis. Covariates were analyzed by bivariate and multivariate logistic regression with SPSS statistical software. The total number of respondents in this study was 422; their median age was 35 years. Among the participants, 95.5% were taking their medication without missing a dose. Factors such as having emotional or practical support positively encouraged ART adherence (adjusted odds ratio 0.16 [95% CI 0.05–0.49]. However, users of traditional, complementary, and alternative medicine (TCAM (adjusted odds ratio 4.7 [95% CI 1.06–21.22] had nearly a five times higher risk for ART nonadherence (P<0.05 than those not using

  19. Properties of inactive Photosystem II centers. (United States)

    Lavergne, J; Leci, E


    A fraction (usually in the range of 10-25%) of PS II centers is unable to transfer electrons from the primary quinone acceptor QA to the secondary acceptor QB. These centers are inactive with respect to O2 evolution since their reopening after photochemical charge separation to the S2OA (-) state involves predominantly a back reaction to S1QA in the few seconds time range (slower phases are also occurring). Several properties of these centers are analyzed by fluorescence and absorption change experiments. The initial rise phase Fo-Fpl of fluorescence induction under weak illumination reflects both the closure of inactive centers and the modulation of the fluorescence yield by the S-states of the oxygen-evolving system: We estimate typical relative amplitudes of these contributions as, respectively, 65 and 35% of the Fo-Fpl amplitude. The half-rise time of this phase is significantly shorter than for the fluorescence induction in the presence of DCMU (in which all centers are involved). This finding is shown to be consistent with inactive centers sharing the same light-harvesting antenna as normal centers, a view which is also supported by comparing the dependence of the fluorescence yield on the amount of closed active or inactive centers estimated through absorption changes. It is argued that the exponential kinetics of the Fo-Fpl phase does not indicate absence of excitation energy transfer between the antennas of inactive and active centers. We show that the acceptor dichlorobenzoquinone does not restore electron transfer in inactive centers, in disagreement with previous suggestions. We confirm, however, the enhancement of steady-state electron flow caused by this quinone and suggest that it acts by relieving a blocking step involved in the reoxidation of a fraction of the plastoquinone pool. Part of the discrepancies between the present results and those from previous literature may arise from the confusion of inactive centers characterized on a single

  20. Antifungal prophylaxis in stem cell transplantation centers in Turkey

    Directory of Open Access Journals (Sweden)

    Hamdi Akan


    Full Text Available Objective: This study aimed to determine the current state of antifungal prophylaxis in Turkish stem cell transplantation (SCT centers. Materials and Methods: The were 38 active stem cell transplantation centers in Turkey, 28 of which were registered with the European Group for Blood and Marrow Transplantation (EBMT. Survey questionnaires were sent to the 28 EBMT centers in an effort to collect data on antifungal prophylaxis in different settings. In all, 24 of the centers completed the survey; 1 of the 24 centers was excluded from the study, as it was under construction at the time and was not performing transplantation.Results: In all, 15 (65% of the 23 centers were adult SCT centers, 7 (31% were pediatric SCT centers, and 1 center treated both adult and pediatric patients. All centers (23/23 performed both allogeneic and autologous transplants, 20 centers performed non-myeloablative transplants, 8 performed cord blood transplants, and 7 performed unrelated transplants. Primary antifungal prophylaxis was used at all 23 centers during allogeneic transplants, whereas 18 of the 23 centers used it during every autologous transplant and 2 of the 23 centers used it during autologous transplants on a per case basis. The most common drug used for prophylaxis was fluconazole (F (21/23, followed by itraconazole (I (3/23, amphotericin-B (2/23, and posaconazole (1/23. Among the 23 centers, 3 reported that for allogenic transplants they changed the antifungal prophylactic in cases of graft versus host disease (GVHD, and 12 of the 23 centers reported that they changed the antifungal prophylactic in case of nearby construction. All 23 centers performed secondary prophylaxis. Conclusion: Antifungal prophylaxis for hematopoetic SCT patients was the standard protocol in the 23 centers included in the study, usually with such azoles as F. The introduction of posaconazole in Turkey and the potential approval of voriconazole for antifungal prophylaxis will

  1. Entanglement with Centers

    CERN Document Server

    Ma, Chen-Te


    Entanglement is a physical phenomenon that each state cannot be described individually. Entanglement entropy gives quantitative understanding to the entanglement. We use decomposition of the Hilbert space to discuss properties of the entanglement. Therefore, partial trace operator becomes important to define the reduced density matrix from different centers, which commutes with all elements in the Hilbert space, corresponding to different entanglement choices or different observations on entangling surface. Entanglement entropy is expected to satisfy the strong subadditivity. We discuss decomposition of the Hilbert space for the strong subadditivity and other related inequalities. The entanglement entropy with centers can be computed from the Hamitonian formulations systematically, provided that we know wavefunctional. In the Hamitonian formulation, it is easier to obtain symmetry structure. We consider massless $p$-form theory as an example. The massless $p$-form theory in ($2p+2)$-dimensions has global symm...

  2. Home media center


    Valverde Martinez, Juan Miguel


    One of the most popular indoor entertainment systems nowadays is related to playing multimedia files, not only at home but also in public events such as watching movies in cinemas or playing music in nightclubs or pubs. Developers are responsible for making this easier and innovating in the development of these systems in different ways. This project's goal was to develop a home media center which allows the user to play multimedia files easily. In addition, the development was intended t...


    Energy Technology Data Exchange (ETDEWEB)



    The Brookhaven Computational Science Center brings together researchers in biology, chemistry, physics, and medicine with applied mathematicians and computer scientists to exploit the remarkable opportunities for scientific discovery which have been enabled by modern computers. These opportunities are especially great in computational biology and nanoscience, but extend throughout science and technology and include for example, nuclear and high energy physics, astrophysics, materials and chemical science, sustainable energy, environment, and homeland security.

  4. Strategic Project Management at the NASA Kennedy Space Center (United States)

    Lavelle, Jerome P.


    This paper describes Project Management at NASA's Kennedy Space Center (KSC) from a strategic perspective. It develops the historical context of the agency and center's strategic planning process and illustrates how now is the time for KSC to become a center which has excellence in project management. The author describes project management activities at the center and details observations on those efforts. Finally the author describes the Strategic Project Management Process Model as a conceptual model which could assist KSC in defining an appropriate project management process system at the center.

  5. Radiological protection and calibration of an activity meter with cesium and barium sources in a nuclear medicine center; Proteccion radiologica y calibracion de un activimetro con fuentes de cesio y bario en un centro de medicina nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Morales L, M.E. [IPEN INEN Centro de Medicina Nuclear, Av. Aviacion 3799, Lima 34 (Peru)


    Presently work is shown the results when gauging a team Deluxe Isotope (Caliper 11) with some sources of Cesium 137 and Barium 133, in a Center of Medicine Nuclear that operates from the anus 1983 in a modern building inside the one Institute of Illnesses Neoplasia (Inn). This Center was equipped initially with teams donated by the International Organism of Atomic Energy (Oa) with those that it develops assistance, educational works and of investigation, giving services to patient of the Inn and other public and private medical centers. (Author)

  6. Reinventing the academic health center. (United States)

    Kirch, Darrell G; Grigsby, R Kevin; Zolko, Wayne W; Moskowitz, Jay; Hefner, David S; Souba, Wiley W; Carubia, Josephine M; Baron, Steven D


    Academic health centers have faced well-documented internal and external challenges over the last decade, putting pressure on organizational leaders to develop new strategies to improve performance while simultaneously addressing employee morale, patient satisfaction, educational outcomes, and research growth. In the aftermath of a failed merger, new leaders of The Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center encountered a climate of readiness for a transformational change. In a case study of this process, nine critical success factors are described that contributed to significant performance improvement: performing a campus-wide cultural assessment and acting decisively on the results; making values explicit and active in everyday decisions; aligning corporate structure and governance to unify the academic enterprise and health system; aligning the next tier of administrative structure and function; fostering collaboration and accountability-the creation of unified campus teams; articulating a succinct, highly focused, and compelling vision and strategic plan; using the tools of mission-based management to realign resources; focusing leadership recruitment on organizational fit; and "growing your own" through broad-based leadership development. Outcomes assessment data for academic, research, and clinical performance showed significant gains between 2000 and 2004. Organizational transformation as a result of the nine factors is possible in other institutional settings and can facilitate a focus on crucial quality initiatives.

  7. Solar thermal activation study of the Land of Hessen. Study on solar options for municipal swimming pools, gymnasia and sports centers in Hessen. Solarthermische Aktivierungsstudie Hessen. Studie zur solaren Eignung von kommunalen Freibaedern sowie Turn- und Sporthallen in Hessen

    Energy Technology Data Exchange (ETDEWEB)


    This study is to give communities and districts in the Land of Hessen a decision aid on whether solar service water or pool water heating would be an economically efficient alternative in numerical swimming pools or sports centers. (orig.)

  8. Advantage from Funding Durable Centers Leasing

    Directory of Open Access Journals (Sweden)

    Alina Zając


    Full Text Available In present market conditions huge number of businessmen has problems from gain over from banks capital on purchase of durable centers not only, but also on develop - ment and operating activity Individual can use with different forms funding investment, it which is between different leasing.

  9. Merging a Library and a Computing Center. (United States)

    Plane, Robert A.


    Details are provided of the development of a new library at Clarkson College. It was seen from the start that the new center needed to be viewed as the hub of a campus-wide system to provide integrated informational support for instructional, research, and administrative activities of the entire college. (MP)

  10. Cosmos, an international center for advanced studies (United States)

    Ryzhov, Iurii; Alifanov, Oleg; Sadin, Stanley; Coleman, Paul


    The concept of Cosmos, a Soviet operating center for aerospace activities, is presented. The main Cosmos participants are the Institute for Aerospace Education, the Institute for Research and Commercial Development, and the Department of Space Policy and Socio-Economic Studies. Cosmos sponsors a number of educational programs, basic research, and studies of the social impact of space-related technologies.

  11. Does an Integrated Care Intervention for COPD Patients Have Long-Term Effects on Quality of Life and Patient Activation? A Prospective, Open, Controlled Single-Center Intervention Study (United States)

    Bentsen, Signe Berit; Sunde, Synnøve; Steinshamn, Sigurd


    Background Implementation of the COPD-Home integrated disease management (IDM) intervention at discharge after hospitalizations for acute exacerbations of COPD (AECOPD) led to reduced hospital utilization during the following 24 months compared to the year prior to study start. Aims To analyze the impact of the COPD-Home IDM intervention on health related quality of life, symptoms of anxiety and depression, and the degree of patient activation during 24 months of follow-up and to assess the association between these outcomes. Methods A single center, prospective, open, controlled clinical study. Changes in The St. George Respiratory Questionnaire (SGRQ), the Hospital anxiety (HADS-A) and depression (HADS-D) and the patient activation measure (PAM) scores were compared between the patients in the integrated care group (ICG) and the usual care group (UCG) 6, 12 and 24 months after enrolment. Results The questionnaire response rate was 80–96%. There were no statistically significant differences in the change of the SGRQ scores between the groups during follow up. After 12 months of follow-up there was a trend towards a reduction in the mean HADS–A score in the ICG compared to the UCG. The HADS-D scores remained stable in the ICG compared with an increasing trend in the UCG. Clinically significant difference in the PAM score was achieved only in the ICG, 6.7 (CI95% 0.7 to 7.5) compared to 3.6 (CI95% -1.4 to 8.6) in the UCG. In a logistic regression model a higher HADS-D score and current smoking significantly increased the odds for a low PAM score. Conclusion The COPD–Home IDM intervention did not result in any statistically significant changes in mean SGRQ, HADS-A, HADS- D or PAM scores during the 24 months of follow-up. Trial registration The ID number for the study in the registration system is 17417. Identifier: NCT 00702078 PMID:28060921

  12. Health risks of workers fish farming center

    Directory of Open Access Journals (Sweden)

    Jorge L. Minchola Gallardo


    Full Text Available In this study we evaluated the ergonomic risks in workers' health Fish Farming Center. The sample universe consisted of the 15 workers of Motil Fish Farming Center, Department of La Libertad, Peru. Samples were taken every month. The methods used to assess ergonomic ergonomic risk were: Job Strain Index (JSI, Rapid Entire Body Assessment (REBA and Oako Working Analysis System (OWAS. The Results demonstrated by the methods of JSI and REBA that selection and maintenance activities are generating greater risks, and, according to the method OWAS, the activity that generates higher risks is that of selection, followed by selection activities of gravid females and maintenance. It was concluded that the activities that need immediate corrective measures are the selection and maintenance.

  13. Memorial Center - Milwaukee

    Directory of Open Access Journals (Sweden)

    Saarinen, Eero


    Full Text Available El Memorial Center de Milwaukee ha sido erigido en la parte más alta de la ciudad, coronando una enorme colina que domina ampliamente el conjunto urbano y un hermoso lago. Su emplazamiento, al final de un puente de grandes dimensiones, exigía que fuese tratado en armonía con éste, habiéndose adoptado por ello el sistema de colocar la edificación reposando sobre una planta totalmente diáfana que deja vista la estructura, cuyos esbeltos soportes dan sensación de monumentalidad.


    Energy Technology Data Exchange (ETDEWEB)



    The Brookhaven Computational Science Center brings together researchers in biology, chemistry, physics, and medicine with applied mathematicians and computer scientists to exploit the remarkable opportunities for scientific discovery which have been enabled by modern computers. These opportunities are especially great in computational biology and nanoscience, but extend throughout science and technology and include, for example, nuclear and high energy physics, astrophysics, materials and chemical science, sustainable energy, environment, and homeland security. To achieve our goals we have established a close alliance with applied mathematicians and computer scientists at Stony Brook and Columbia Universities.

  15. 固体催化剂活性中心的分子设计及其XAFS表征%Molecular Design and XAFS Characterization of Active Centers of Solid-State Catalysts

    Institute of Scientific and Technical Information of China (English)

    龙金林; 顾泉; 张子重; 王绪绪


    Surface organometallic chemistry(SOMC) is an effective route to design and prepare surface metal species with well-defined composition and molecular structure.Synchrotron radiation X-ray absorption fine structure spectroscopy(XAFS) technique is currently a powerful tool to characterize geometrical structure of active sites of solid-state catalysts.Their combination provided a method to design and construct in molecular level catalytic active centres,which was established to be one of the important goals in the field of heterogeneous catalysis.This article reviews the recent advancements in construction of single-site active metallic centre in the channels and cages of zeolite molecular sieves by the SOMC method and in characterizing geometrical structure of active sites of heterogeneous catalytic materials with XAFS,the physical fundament,experimental methods,and data analysis of XAFS technique and its merits and demerits in characterization of catalytic materials,the chemical fundament of SOMC.Single-site mononuclear or polynuclear Ti,Cu,and Fe active centers were successfully constructed in molecular level in the channels and cages of zeolite molecular sieves by the SOMC method.Their micro-structures were characterized in detail with XAFS combined other spectroscopic techniques and their catalytic properties were evaluated.The catalytic nature of these metallic centers was elucidated by establishing the inherent relationship among structure,activity,and composition.The study results revealed in molecular level the pyrolysis mechanism of Cu2 over the MCM-41 surface,and showed a novel route to prepare CuO,Cu2O and Cu(0)/MCM-41 materials with well-defined composition and micro-structure,clarifying the hydroxylation mechanism of phenol over copper active sites and the nuclearity-dependent catalytic function of iron-oxo species;based on the binuclear diiron [FeIII-(μ-O)(μ-OH)-FeⅢ] clusters with well-defined structure and composition constructed

  16. Data center coolant switch

    Energy Technology Data Exchange (ETDEWEB)

    Iyengar, Madhusudan K.; Parida, Pritish R.; Schultz, Mark D.


    A data center cooling system is operated in a first mode; it has an indoor portion wherein heat is absorbed from components in the data center, and an outdoor heat exchanger portion wherein outside air is used to cool a first heat transfer fluid (e.g., water) present in at least the outdoor heat exchanger portion of the cooling system during the first mode. The first heat transfer fluid is a relatively high performance heat transfer fluid (as compared to the second fluid), and has a first heat transfer fluid freezing point. A determination is made that an appropriate time has been reached to switch from the first mode to a second mode. Based on this determination, the outdoor heat exchanger portion of the data cooling system is switched to a second heat transfer fluid, which is a relatively low performance heat transfer fluid, as compared to the first heat transfer fluid. It has a second heat transfer fluid freezing point lower than the first heat transfer fluid freezing point, and the second heat transfer fluid freezing point is sufficiently low to operate without freezing when the outdoor air temperature drops below a first predetermined relationship with the first heat transfer fluid freezing point.

  17. National Center for Biotechnology Information (United States)

    ... to NCBI Sign Out NCBI National Center for Biotechnology Information Search database All Databases Assembly BioProject BioSample ... Search Welcome to NCBI The National Center for Biotechnology Information advances science and health by providing access ...

  18. Daugherty Memorial Assessment Center (DMAC) (United States)

    Federal Laboratory Consortium — Daugherty Memorial Assessment Center (DMAC) is a 39,000-square-foot facility that doubles the warfare center's high-secured performance assessment capabilities. DMAC...

  19. VT Designated Village Centers Boundary (United States)

    Vermont Center for Geographic Information — This community revitalization program helps maintain or evolve small to medium-sized historic centers with existing civic and commercial buildings. The designation...

  20. Center for Veterinary Medicine (CVM) (United States)

    Federal Laboratory Consortium — As seen on the center's logo, the mission statement for FDA's Center for Veterinary Medicine (CVM) reads: "Protecting Human and Animal Health." To achieve this broad...

  1. Center for Prostate Disease Research (United States)

    Federal Laboratory Consortium — The Center for Prostate Disease Research is the only free-standing prostate cancer research center in the U.S. This 20,000 square foot state-of-the-art basic science...

  2. Contact Center Manager Administration (CCMA) (United States)

    Social Security Administration — CCMA is the server that provides a browser-based tool for contact center administrators and supervisors. It is used to manage and configure contact center resources...

  3. National Center on Family Homelessness (United States)

    ... You are here Home National Center on Family Homelessness Center A staggering 2.5 million children are ... raise awareness of the current state of child homelessness in the United States, documents the number of ...

  4. Center of excellence in laser medicine. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Parrish, J.A.


    Achievements during the first six months of funding to prepare for a Center of Excellence in biomedical laser development include limited specific research projects within the Center`s three broad interest areas, and program development to establish the Center and its activities. Progress in the three interest areas -- new medical laser systems development, optical diagnostics, and photosensitization, is reported. Feasibility studies and prototype development were emphasized, to enhance establishing a substantial Center through future support. Specific projects are an optimized laser-catheter system for reversal of vasospasm; optical detection of major skin burn depth and cancers using fluorescent drugs, and photosensitization of vascular tissues. In addition, an interdepartmental Laser Center was established at MGH to enhance collaborations and institutional committment to the Center of Excellence. Competitive postdoctoral research fellowships, with provision for matching funds from other departments, have been announced.

  5. Light saturation response of inactive photosystem II reaction centers in spinach. (United States)

    Chylla, R A; Whitmarsh, J


    The effective absorption cross section of inactive photosystem II (PS II) centers, which is the product of the effective antenna size and the quantum yield for photochemistry, was investigated by comparing the light saturation curves of inactive PS II and active reaction centers in intact chloroplasts and thylakoid membranes of spinach (Spinacia oleracea). Inactive PS II centers are defined as the impaired PS II reaction centers that require greater than 50 ms for the reoxidation of QA (-) subsequent to a single turnover flash. Active reaction centers are defined as the rapidly turning over PS II centers (recovery time less than 50 ms) and all of the PS I centers. The electrochromic shift, measured by the flash-induced absorbance increase at 518 nm, was used to probe the activity of the reaction centers. Light saturation curves were generated for inactive PS II centers and active reaction centers by measuring the extent of the absorbance increase at 518 nm induced by red actinic flashes of variable energy. The light saturation curves show that inactive PS II centers required over twice as many photons as active reaction centers to achieve the same yield. The ratio of the flash energy required for 50% saturation for active reaction centers (PS II active + PS I) compared to inactive PS II centers was 0.45±0.04 in intact chloroplasts, and 0.54±0.11 in thylakoid membranes. Analysis of the light saturation curves using a Poisson statistical model in which the ratio of the antenna size of active PS II centers to that of PS I is considered to range from 1 to 1.5, indicates that the effective absorption cross section of inactive PS II centers was 0.54-0.37 times that of active PS II centers. If the quantum yield for photochemistry is assumed to be one, we estimate that the antenna system serving the inactive PS II centers contains approx. 110 chlorophyll molecules.

  6. On chains of centered valuations

    Directory of Open Access Journals (Sweden)

    Rachid Chibloun


    Full Text Available We study chains of centered valuations of a domain A and chains of centered valuations of A [X1,…,Xn] corresponding to valuations of A. Finally, we make some applications to chains of valuations centered on the same ideal of A [X1,…,Xn] and extending the same valuation of A.


    California State Dept. of Education, Sacramento.


  8. Citizen centered design

    Directory of Open Access Journals (Sweden)

    Ingrid Mulder


    Full Text Available Today architecture has to design for rapidly changing futures, in a citizen-centered way. That is, architecture needs to embrace meaningful design. Societal challenges ask for a new paradigm in city-making, which combines top-down public management with bottom-up social innovation to reach meaningful design. The biggest challenge is indeed to embrace a new collaborative attitude, a participatory approach, and to have the proper infrastructure that supports this social fabric. Participatory design and transition management are future-oriented, address people and institutions. Only through understanding people in context and the corresponding dynamics, one is able to design for liveable and sustainable urban environments, embracing the human scale.

  9. Mi Pueblo Food Center

    Directory of Open Access Journals (Sweden)

    Alexis A. Babb


    Full Text Available This case describes a current growth opportunity for Mi Pueblo Food Center, a Hispanic grocery chain with locations throughout the Bay Area, California. The CEO of Mi Pueblo is contemplating opening a new store location in East Palo Alto, CA, which has been without a local, full-service grocery store for over 20 years. Case objectives are for students to develop an understanding of how the grocery industry operates, the risks and opportunities associated with opening a new grocery store location, and the impact on social, environmental, and economic sustainability. The SWOT (Strengths, Weaknesses, Opportunities, Threats framework is used to analyze whether or not it is feasible for Mi Pueblo to open a new location in East Palo Alto. This case may be used with students in graduate and advanced undergraduate courses.

  10. Supernova Science Center

    Energy Technology Data Exchange (ETDEWEB)

    S. E. Woosley


    The Supernova Science Center (SNSC) was founded in 2001 to carry out theoretical and computational research leading to a better understanding of supernovae and related transients. The SNSC, a four-institutional collaboration, included scientists from LANL, LLNL, the University of Arizona (UA), and the University of California at Santa Cruz (UCSC). Intitially, the SNSC was funded for three years of operation, but in 2004 an opportunity was provided to submit a renewal proposal for two years. That proposal was funded and subsequently, at UCSC, a one year no-cost extension was granted. The total operational time of the SNSC was thus July 15, 2001 - July 15, 2007. This document summarizes the research and findings of the SNSC and provides a cummulative publication list.

  11. Industrial Assessment Center Program

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Dereje Agonafer


    The work described in this report was performed under the direction of the Industrial Assessment Center (IAC) at University of Texas at Arlington. The IAC at The University of Texas at Arlington is managed by Rutgers University under agreement with the United States Department of Energy Office of Industrial Technology, which financially supports the program. The objective of the IAC is to identify, evaluate, and recommend, through analysis of an industrial plant’s operations, opportunities to conserve energy and prevent pollution, thereby reducing the associated costs. IAC team members visit and survey the plant. Based upon observations made in the plant, preventive/corrective actions are recommended. At all times we try to offer specific and quantitative recommendations of cost savings, energy conservation, and pollution prevention to the plants we serve.

  12. The Center is Everywhere

    CERN Document Server

    Weinberg, David H


    "The Center is Everywhere" is a sculpture by Josiah McElheny, currently (through October 14, 2012) on exhibit at the Institute of Contemporary Art, Boston. The sculpture is based on data from the Sloan Digital Sky Survey (SDSS), using hundreds of glass crystals and lamps suspended from brass rods to represent the three-dimensional structure mapped by the SDSS through one of its 2000+ spectroscopic plugplates. This article describes the scientific ideas behind this sculpture, emphasizing the principle of the statistical homogeneity of cosmic structure in the presence of local complexity. The title of the sculpture is inspired by the work of the French revolutionary Louis Auguste Blanqui, whose 1872 book "Eternity Through The Stars: An Astronomical Hypothesis" was the first to raise the spectre of the infinite replicas expected in an infinite, statistically homogeneous universe. Puzzles of infinities, probabilities, and replicas continue to haunt modern fiction and contemporary discussions of inflationary cosmo...

  13. Actions Needed to Ensure Scientific and Technical Information is Adequately Reviewed at Goddard Space Flight Center, Johnson Space Center, Langley Research Center, and Marshall Space Flight Center (United States)


    This audit was initiated in response to a hotline complaint regarding the review, approval, and release of scientific and technical information (STI) at Johnson Space Center. The complainant alleged that Johnson personnel conducting export control reviews of STI were not fully qualified to conduct those reviews and that the reviews often did not occur until after the STI had been publicly released. NASA guidance requires that STI, defined as the results of basic and applied scientific, technical, and related engineering research and development, undergo certain reviews prior to being released outside of NASA or to audiences that include foreign nationals. The process includes technical, national security, export control, copyright, and trade secret (e.g., proprietary data) reviews. The review process was designed to preclude the inappropriate dissemination of sensitive information while ensuring that NASA complies with a requirement of the National Aeronautics and Space Act of 1958 (the Space Act)1 to provide for the widest practicable and appropriate dissemination of information resulting from NASA research activities. We focused our audit on evaluating the STI review process: specifically, determining whether the roles and responsibilities for the review, approval, and release of STI were adequately defined and documented in NASA and Center-level guidance and whether that guidance was effectively implemented at Goddard Space Flight Center, Johnson Space Center, Langley Research Center, and Marshall Space Flight Center. Johnson was included in the review because it was the source of the initial complaint, and Goddard, Langley, and Marshall were included because those Centers consistently produce significant amounts of STI.

  14. A Computer Learning Center for Environmental Sciences (United States)

    Mustard, John F.


    In the fall of 1998, MacMillan Hall opened at Brown University to students. In MacMillan Hall was the new Computer Learning Center, since named the EarthLab which was outfitted with high-end workstations and peripherals primarily focused on the use of remotely sensed and other spatial data in the environmental sciences. The NASA grant we received as part of the "Centers of Excellence in Applications of Remote Sensing to Regional and Global Integrated Environmental Assessments" was the primary source of funds to outfit this learning and research center. Since opening, we have expanded the range of learning and research opportunities and integrated a cross-campus network of disciplines who have come together to learn and use spatial data of all kinds. The EarthLab also forms a core of undergraduate, graduate, and faculty research on environmental problems that draw upon the unique perspective of remotely sensed data. Over the last two years, the Earthlab has been a center for research on the environmental impact of water resource use in and regions, impact of the green revolution on forest cover in India, the design of forest preserves in Vietnam, and detailed assessments of the utility of thermal and hyperspectral data for water quality analysis. It has also been used extensively for local environmental activities, in particular studies on the impact of lead on the health of urban children in Rhode Island. Finally, the EarthLab has also served as a key educational and analysis center for activities related to the Brown University Affiliated Research Center that is devoted to transferring university research to the private sector.

  15. Genetic Science Learning Center (United States)

    ... Mouse Party on Students doing the Tree of Genetic Traits activity Learn.Genetics is one of the most widely used science education websites in the world The Community Genetics ...

  16. Current Practice and Infrastructures for Campus Centers of Community Engagement (United States)

    Welch, Marshall; Saltmarsh, John


    This article provides an overview of current practice and essential infrastructure of campus community engagement centers in their efforts to establish and advance community engagement as part of the college experience. The authors identified key characteristics and the prevalence of activities of community engagement centers at engaged campuses…

  17. Cervical helical axis characteristics and its center of rotation during active head and upper arm movements-comparisons of whiplash-associated disorders, non-specific neck pain and asymptomatic individuals. (United States)

    Grip, Helena; Sundelin, Gunnevi; Gerdle, Björn; Stefan Karlsson, J


    The helical axis model can be used to describe translation and rotation of spine segments. The aim of this study was to investigate the cervical helical axis and its center of rotation during fast head movements (side rotation and flexion/extension) and ball catching in patients with non-specific neck pain or pain due to whiplash injury as compared with matched controls. The aim was also to investigate correlations with neck pain intensity. A finite helical axis model with a time-varying window was used. The intersection point of the axis during different movement conditions was calculated. A repeated-measures ANOVA model was used to investigate the cervical helical axis and its rotation center for consecutive levels of 15 degrees during head movement. Irregularities in axis movement were derived using a zero-crossing approach. In addition, head, arm and upper body range of motion and velocity were observed. A general increase of axis irregularity that correlated to pain intensity was observed in the whiplash group. The rotation center was superiorly displaced in the non-specific neck pain group during side rotation, with the same tendency for the whiplash group. During ball catching, an anterior displacement (and a tendency to an inferior displacement) of the center of rotation and slower and more restricted upper body movements implied a changed movement strategy in neck pain patients, possibly as an attempt to stabilize the cervical spine during head movement.

  18. Recycling of solid wastes at kindergartens centers

    Directory of Open Access Journals (Sweden)

    Mohamed R.M.S.R.


    Full Text Available The present study aimed to conduct an activity on environmental awareness campaign at a kindergarten center, with the children age 4-6 years old. The activity included identify the various types of waste generated at the kindergarten and to realize the conservation practice by participating in simple waste management strategies and an explanation about recycling, reusing and reducing waste (3R. The activity provided the children more awareness about the importance of minimizing the plastic wastes. The activity had created an interesting experience to the young generation through practice activity and has given a light on the nature conservation along their growing years. It can be concluded that the awareness of environmental issues among children have risen up as noted by looking at students physical expression. Children have understood the potential to conserve nature from a simple action which is recycling. After the activity, children’s were able to identify and divide the rubbish.

  19. Global Challenges in People-Centered E-Health. (United States)

    Quintana, Yuri; Safran, Charles


    People-centered health care seeks an active role for the patient while empowering all other members of the health care team. By promoting greater patient responsibility and optimal usage, patient-centered health care leads to improved health outcomes, quality of life and optimal value for health care investment. This paper reviews some definitions of people-centered health care and various e-health approaches around the world used to implement this vision. The barriers and enablers to implementation this type of approach are explored. This paper provides a proposed research agenda for future implementations of people-centered e-health.


    This presentation provides an overview of the remote sensing technical support and research and development activities of the Environmental Photographic Interprettion Center (EPIC). It is the basis for a presentation given at the EPA's Office of Acquisition Management's Annual C...

  1. University of Illinois at Chicago Health Policy Center - Funding (United States)

    U.S. Department of Health & Human Services — 1991-2014. Centers for Disease Control and Prevention (CDC). State Tobacco Activities Tracking and Evaluation (STATE) System. Funding Data, Appropriations...

  2. Satellite medical centers project (United States)

    Aggarwal, Arvind


    World class health care for common man at low affordable cost: anywhere, anytime The project envisages to set up a national network of satellite Medical centers. Each SMC would be manned by doctors, nurses and technicians, six doctors, six nurses, six technicians would be required to provide 24 hour cover, each SMC would operate 24 hours x 7 days. It would be equipped with the Digital telemedicine devices for capturing clinical patient information and investigations in the form of voice, images and data and create an audiovisual text file - a virtual Digital patient. Through the broad band connectivity the virtual patient can be sent to the central hub, manned by specialists, specialists from several specialists sitting together can view the virtual patient and provide a specialized opinion, they can see the virtual patient, see the examination on line through video conference or even PCs, talk to the patient and the doctor at the SMC and controlle capturing of information during examination and investigations of the patient at the SMC - thus creating a virtual Digital consultant at the SMC. Central hub shall be connected to the doctors and consultants in remote locations or tertiary care hospitals any where in the world, thus creating a virtual hub the hierarchical system shall provide upgradation of knowledge to thedoctors in central hub and smc and thus continued medical education and benefit the patient thru the world class treatment in the smc located at his door step. SMC shall be set up by franchisee who shall get safe business opportunity with high returns, patients shall get Low cost user friendly worldclass health care anywhere anytime, Doctors can get better meaningful selfemplyment with better earnings, flexibility of working time and place. SMC shall provide a wide variety of services from primary care to world class Global consultation for difficult patients.

  3. Center for Rehabilitation Sciences Research (United States)

    Federal Laboratory Consortium — The Center for Rehabilitation Sciences Research (CRSR) was established as a research organization to promote successful return to duty and community reintegration of...

  4. Energetics Manufacturing Technology Center (EMTC) (United States)

    Federal Laboratory Consortium — The Energetics Manufacturing Technology Center (EMTC), established in 1994 by the Office of Naval Research (ONR) Manufacturing Technology (ManTech) Program, is Navy...

  5. Center for Environmental Health Sciences (United States)

    Federal Laboratory Consortium — The primary research objective of the Center for Environmental Health Sciences (CEHS) at the University of Montana is to advance knowledge of environmental impacts...

  6. Consolidated Copayment Processing Center (CCPC) (United States)

    Department of Veterans Affairs — The Consolidated Copayment Processing Center (CCPC) database contains Veteran patient contact and billing information in order to support the printing and mailing of...

  7. Center for Neuroscience & Regenerative Medicine (United States)

    Federal Laboratory Consortium — The Center for Neuroscience and Regenerative Medicine (CNRM) was established as a collaborative intramural federal program involving the U.S. Department of Defense...

  8. Molecular Science Research Center 1992 annual report

    Energy Technology Data Exchange (ETDEWEB)

    Knotek, M.L.


    The Molecular Science Research Center is a designated national user facility, available to scientists from universities, industry, and other national laboratories. After an opening section, which includes conferences hosted, appointments, and projects, this document presents progress in the following fields: chemical structure and dynamics; environmental dynamics and simulation; macromolecular structure and dynamics; materials and interfaces; theory, modeling, and simulation; and computing and information sciences. Appendices are included: MSRC staff and associates, 1992 publications and presentations, activities, and acronyms and abbreviations.

  9. The Galactic Center compared with nuclei of nearby galaxies (United States)

    Combes, Francoise


    Understanding our Galactic Center is easier with insights from nearby galactic nuclei. Both the star formation activity in nuclear gas disks, driven by bars and nuclear bars, and the fueling of low-luminosity AGN, followed by feedback of jets, driving molecular outflows, were certainly present in our Galactic Center, which appears now quenched. Comparisons and diagnostics are reviewed, in particular of m = 2 and m = 1 modes, lopsidedness, different disk orientations, and fossil evidences of activity and feedback.

  10. The Galactic Center compared with nuclei of nearby galaxies

    CERN Document Server

    Combes, F


    Understanding our Galactic Center is easier with insights from nearby galactic nuclei. Both the star formation activity in nuclear gas disks, driven by bars and nuclear bars, and the fueling of low-luminosity AGN, followed by feedback of jets, driving molecular outflows, were certainly present in our Galactic Center, which appears now quenched. Comparisons and diagnostics are reviewed, in particular of m=2 and m=1 modes, lopsidedness, different disk orientations, and fossil evidences of activity and feedback.

  11. Integrative Medicine Program- MD Anderson Cancer Center

    Directory of Open Access Journals (Sweden)

    Richard T Lee


    Full Text Available The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integrative Medicine Center provides clinical services to patients through individual and group programs.  The clinical philosophy of the center is to work collaboratively with the oncology teams to build comprehensive and integrative care plans that are personalized, evidence-based, and safe with the goal of improving clinical outcomes.  The individual services comprise of integrative oncology consultation, acupuncture, meditation, music therapy, nutrition, and oncology massage.  The center also provides a variety of group programs including meditation, yoga, tai chi, cooking classes and others.  Over the past 13 years, over 70,000 patients and families have participated in services and programs offered by the center.  The research portfolio focuses on three main areas: mind-body interventions, acupuncture, and meditation.  This lecture will focus on providing an overview of the Integrative Medicine Program at MD Anderson with a focus on the clinical services provided.  Participants will learn about the integrative clinical model and how this is applied to the care of cancer patients at MD Anderson Cancer Center.  Current and future research topics will be discussed as well as patient cases.


    Energy Technology Data Exchange (ETDEWEB)

    M.A. Ebadian


    The Deactivation and Decommissioning (D&D) Technology Assessment Program (TAP) was developed to provide detailed, comparable data for environmental technologies and to disseminate this data to D&D professionals in a manner that will facilitate the review and selection of technologies to perform decontamination and decommissioning. The objectives for this project include the following: Determine technology needs through review of the Site Technology Coordination Group (STCG) information and other applicable websites and needs databases; Perform a detailed review of industries that perform similar activities as those required in D&D operations to identify additional technologies; Define the technology assessment program for characterization and waste management problem sets; Define the data management program for characterization, dismantlement, and waste management problem sets; Evaluate baseline and innovative technologies under standard test conditions at Florida International University's Hemispheric Center for Environmental Technology (FIU-HCET) and other locations and collect data in the areas of performance, cost, health and safety, operations and maintenance, and primary and secondary waste generation; Continue to locate, verify, and incorporate technology performance data from other sources into the multimedia information system; and Develop the conceptual design for a dismantlement technology decision analysis tool for dismantlement technologies.

  13. NASA New England Outreach Center (United States)


    The NASA New England Outreach Center in Nashua, New Hampshire was established to serve as a catalyst for heightening regional business awareness of NASA procurement, technology and commercialization opportunities. Emphasis is placed on small business participation, with the highest priority given to small disadvantaged businesses, women-owned businesses, HUBZone businesses, service disabled veteran owned businesses, and historically black colleges and universities and minority institutions. The Center assists firms and organizations to understand NASA requirements and to develop strategies to capture NASA related procurement and technology opportunities. The establishment of the NASA Outreach Center serves to stimulate business in a historically underserved area. NASA direct business awards have traditionally been highly present in the West, Midwest, South, and Southeast areas of the United States. The Center guides and assists businesses and organizations in the northeast to target opportunities within NASA and its prime contractors and capture business and technology opportunities. The Center employs an array of technology access, one-on-one meetings, seminars, site visits, and targeted conferences to acquaint Northeast firms and organizations with representatives from NASA and its prime contractors to learn about and discuss opportunities to do business and access the inventory of NASA technology. This stimulus of interaction also provides firms and organizations the opportunity to propose the use of their developed technology and ideas for current and future requirements at NASA. The Center provides a complement to the NASA Northeast Regional Technology Transfer Center in developing prospects for commercialization of NASA technology. In addition, the Center responds to local requests for assistance and NASA material and documents, and is available to address immediate concerns and needs in assessing opportunities, timely support to interact with NASA Centers on

  14. Clean Energy Application Center

    Energy Technology Data Exchange (ETDEWEB)

    Freihaut, Jim


    The Mid Atlantic Clean Energy Application Center (MACEAC), managed by The Penn State College of Engineering, serves the six states in the Mid-Atlantic region (Pennsylvania, New Jersey, Delaware, Maryland, Virginia and West Virginia) plus the District of Columbia. The goals of the Mid-Atlantic CEAC are to promote the adoption of Combined Heat and Power (CHP), Waste Heat Recovery (WHR) and District Energy Systems (DES) in the Mid Atlantic area through education and technical support to more than 1,200 regional industry and government representatives in the region. The successful promotion of these technologies by the MACEAC was accomplished through the following efforts; (1)The MACEAC developed a series of technology transfer networks with State energy and environmental offices, Association of Energy Engineers local chapters, local community development organizations, utilities and, Penn State Department of Architectural Engineering alumni and their firms to effectively educate local practitioners about the energy utilization, environmental and economic advantages of CHP, WHR and DES; (2) Completed assessments of the regional technical and market potential for CHP, WHR and DE technologies application in the context of state specific energy prices, state energy and efficiency portfolio development. The studies were completed for Pennsylvania, New Jersey and Maryland and included a set of incentive adoption probability models used as a to guide during implementation discussions with State energy policy makers; (3) Using the technical and market assessments and adoption incentive models, the Mid Atlantic CEAC developed regional strategic action plans for the promotion of CHP Application technology for Pennsylvania, New Jersey and Maryland; (4) The CHP market assessment and incentive adoption model information was discussed, on a continuing basis, with relevant state agencies, policy makers and Public Utility Commission organizations resulting in CHP favorable incentive

  15. Stennis Visitors Center and Administrative Complex (United States)


    This aerial view shows the John C. Stennis Space Center Visitors Center and main Administrative complex. The Stennis Space Center in Hancock County, Mississippi is NASA's lead center for rocket propulsion testing and for commercial remote sensing.

  16. Allegheny County Kane Regional Center Census (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Total number of residents in each Kane Regional Center facility by race and gender. The Kane Regional Centers are skilled nursing and rehabilitation centers run by...

  17. USGS Colorado Water Science Center bookmark (United States)



    The U.S. Geological Survey Colorado Water Science Center conducts its water-resources activities primarily in Colorado in cooperation with more than 125 different entities. These activities include extensive data-collection efforts and studies of streamflow, water quality, and groundwater to address many specific issues of concern to Colorado water-management entities and citizens. The collected data are provided in the National Water Information System, and study results are documented in reports and information served on the Internet.

  18. The generation of germinal centers

    NARCIS (Netherlands)

    Kroese, Fransciscus Gerardus Maria


    Germinal centers are clusters of B lymphoblastoid cells that develop after antigenic stimulation in follicles of peripheral lymphoid organs. These structures are thought to play a major role in the generation of B memory cells. This thesis is dealing with several aspects of these germinal centers. I

  19. Learning Centers: Development and Operation. (United States)

    Bennie, Frances

    There has been in recent years a growing acceptance of individualized learning concepts. Learning Centers have come to be viewed as an economical and viable strategy for accommodating diverse learning styles and needs. This book provides the educator with an understanding of the learning center concept, its origins, present manifestations, and…

  20. Danish Chinese Center for Nanometals

    DEFF Research Database (Denmark)

    Winther, Grethe

    The Danish-Chinese Center for Nanometals is funded by the Danish National Research Foundation and the National Natural Science Foundation of China. The Chinese partners in the Center are Institute of Metal Research in Shenyang, Tsinghua University and Chongqing University. The Danish part...

  1. Acoustic Center or Time Origin?

    DEFF Research Database (Denmark)

    Staffeldt, Henrik


    The paper discusses the acoustic center in relation to measurements of loudspeaker polar data. Also, it presents the related concept time origin and discusses the deviation that appears between positions of the acoustic center found by wavefront based and time based measuring methods....

  2. PTSD: National Center for PTSD

    Medline Plus

    Full Text Available ... Section Home PTSD Overview PTSD Basics Return from War Specific to Women Types of Trauma War Terrorism Violence and Abuse Disasters Is it PTSD? ... Combat Veterans & their Families Readjustment Counseling (Vet Centers) War Related Illness & Injury Study Center Homeless Veterans Returning ...

  3. User-Centered Design Gymkhana


    Garreta Domingo, Muriel; Almirall Hill, Magí; Mor Pera, Enric


    The User-centered design (UCD) Gymkhana is a tool for human-computer interaction practitioners to demonstrate through a game the key user-centered design methods and how they interrelate in the design process.The target audiences are other organizational departments unfamiliar with UCD but whose work is related to the definition, cretaion, and update of a product service.

  4. Information Sciences: Information Centers and Special Libraries. (United States)


  5. From Periphery To Center

    DEFF Research Database (Denmark)

    Carré, David


    are ‘imported’ into the self as pre-packaged ways of relating, thinking, acting, etc. Therefore, these studies have neglected the unique, developmental and dialogical nature of these transitional processes (Zittoun, 2006). In this vein, becoming-a-scientist is understood here as a dialogical process, guided...... by meaning-making persons oriented towards others (Marková, 2003). This process not only entails the active construction of novel I-Other positions, but also the meaningful re-construction of multiple previous I-positions. Hence, I look to advance existing dialogical approaches on this topic by exploring...

  6. Pengembangan Model Manajemen ICT Center

    Directory of Open Access Journals (Sweden)

    Hakkun Elmunsyah


    Full Text Available Abstrak: Pengembangan Model Manajemen ICT Center. Kemendiknas telah melakukan investasi  cukup besar berupa pembangunan Jejaring komputer pendidikan nasional yang disebut Jaringan Pendidikan Nasional (Jardiknas, pada sekolah menengah kejuruan (SMK di seluruh Indonesia yang dikenal dengan nama ICT center. Penelitian ini bertujuan untuk menemukan model manajemen ICT center sesuai karakteristik SMK sehingga dapat memberikan kontribusi mutu pada SMK tersebut. Penelitian ini merupakan penelitian pengembangan atau Research and Development yang dikembangkan oleh Borg and Gall. Hasil secara keseluruhan penelitian menunjukkan berdasarkan uji coba keefektivan kinerja manajemen pada skala terbatas dan lebih luas menunjukkan bahwa model manajemen ICT center memenuhi kriteria sangat efektif. Kata-kata kunci: Jardiknas, SMK, model manajemen ICT center, kontribusi mutu

  7. Marine Renewable Energy Center

    Energy Technology Data Exchange (ETDEWEB)

    Vigeant, Paul [Univ. of Massachusetts, Dartmouth, MA (United States); Miller, John [Univ. of Massachusetts, Dartmouth, MA (United States); Howes, Brian [Univ. of Massachusetts, Dartmouth, MA (United States); McGowan, Jon G. [Univ. of Massachusetts, Amherst, MA (United States); Baldwin, Kenneth [Univ. of New Hampshire, Durham, NH (United States); Grilli, Annette [Univ. of Rhode Island, Kingston, RI (United States); Terray, Eugene [Woods Hole Oceanographic Inst., Woods Hole, MA (United States)


    Project Goals: The funding provided by this contract supported the following activities: A) Test Site Development; B) Seed Grant Funded Technology Development; C) Stakeholder Activities The first year of funding was dedicated to the formation of the NE MREC University Consortium which was comprised of University of Massachusetts Dartmouth (UMD) and Amherst (UMA), Massachusetts Institute of Technology (MIT), Woods Hole Oceanographic Institution (WHOI), University of New Hampshire (UNH), and the University of Rhode Island (URI). The consortium worked together to encourage research and promote benefits of obtaining energy from ocean wind, waves, tides and currents. In addition, NE MREC’s goal was to fund projects aimed at potential test sites with the first year funding going to studies of the potential for tidal device testing in Muskeget Channel, at the General Sullivan Bridge in New Hampshire, and for wave device testing at the proposed National Offshore Renewable Energy Innovation Zone (NOREIZ) located off the Massachusetts coast. The project spanned 4.5 years and addressed three specific tasks that are interrelated but also served as independent investigations.

  8. National audit of drug information centers. (United States)

    Dombrowski, S R; Visconti, J A


    A comprehensive audit of drug information centers (DICs) was conducted to obtain information on sources of funding, staffing, information resources, computerization, workload, and scope of services and activities and to examine the role of DICs in education, patient care, and research. Responses were obtained from 98 of the 121 DICs surveyed. The scope of activities and services varied considerably between centers and depended on such factors as source of funding, size of institution, academic affiliation, staffing, and workload. Many DICs are involved in writing newsletters, preparing information for pharmacy and therapeutics committee meetings, developing and updating formularies, and providing contract services to other organizations. The patient-care activities of DICs include providing consultations, performing drug-use reviews, monitoring adverse drug reactions, and coordinating investigational drug studies; DICs are also involved in training undergraduate and graduate pharmacy students and residents and conducting research projects. Large workloads and lack of time were cited most often as factors limiting DIC participation in patient-care, educational, and research activities. Because DICs are involved in a wide variety of educational, research, and patient-care activities, more emphasis should be placed on documenting the costs of these services in relation to their benefits to the institution.

  9. Sustainable Technology Research and Demonstration Center for Earth Structures

    Directory of Open Access Journals (Sweden)

    Judy Ueda


    Full Text Available This is a discussion paper that the authors presented at the International Workshop on Rammed Earth Materials and Sustainable Structures and Hakka Tulou Forum 2011: Structures of Sustainability, 28–31 October 2011, Xiamen University, China. A Sustainable Technology Research and Demonstration Center for Earth Structures is proposed to study, preserve, advance, promote, and implement rammed earth structures. The Center concept including the objectives, scope of activities and benefits of the proposed center are outlined. The Center for Alternative Technology in Wales, UK has been examined as a good base model along with a few successful environmental sustainability initiatives in China. The funding options to establish the proposed center have been discussed. The breadth of activities ultimately depends on funding capability. It is believed that the proposed center development will require significant government support at the initial stage but once corporate sponsorships are in place, the proposed center will potentially become self-supporting. The strategies, for the establishment of the proposed center are also addressed.

  10. The National Center for Ecological Analysis and Synthesis (United States)

    Reichman, O. J.


    The National Center for Ecological Analysis and Synthesis was created in May 1995 with funding from NSF, the State of California, and UCSB. The Center is based on the premise that a significant amount is known about the environment, but that it is scattered in many places and formats. The purpose of the Center is to obtain and utilize existing information to address important ecological questions. The Center was recently funded by NSF for an additional 6 years. The Center supports several types of research activities. A primary mode of research is through Working Groups, projects made up of approximately a dozen scientists who come to NCEAS to concentrate on specific issues that require in-depth analysis of data and synthesis of ideas. In addition, up to six sabbatical visitors (Center Fellows) and 18 Postdoctoral Associates are in residence at the Center. Since the Center began, over 2,400 scientists (including hundreds of students) from the US and 40 other countries have participated in research activities. These scientists have produced more than 380 scientific articles published in 65 journals and 8 books. The topics addressed by research projects at the Center range from the value of the planet's ecosystem services to the ecological impacts of global climate change. The Center is actively involved in developing a Knowledge Network for Biocomplexity ( involving information management tools for access to ecological data, which are highly dispersed and heterogeneous. The research and implementation involves developing a desktop data management system for individuals researchers and research groups. Embedded in the system would be capabilities for developing metadata (data about data), making both the metadata and raw data available to the broad community interested in such information, and data query tools (

  11. Emergency Operations Center ribbon cutting (United States)


    Center Director Gene Goldman and special guests celebrate the opening of the site's new Emergency Operations Center on June 2. Participants included (l t r): Steven Cooper, deputy director of the National Weather Service Southern Region; Tom Luedtke, NASA associate administrator for institutions and management; Charles Scales, NASA associate deputy administrator; Mississippi Gov. Haley Barbour; Gene Goldman, director of Stennis Space Center; Jack Forsythe, NASA assistant administrator for the Office of Security and Program Protection; Dr. Richard Williams, NASA chief health and medical officer; and Weldon Starks, president of Starks Contracting Company Inc. of Biloxi.

  12. Automated Data Submission for the Data Center (United States)

    Wright, D.; Beaty, T.; Wei, Y.; Shanafield, H.; Santhana Vannan, S. K.


    Data centers struggle with difficulties related to data submission. Data are acquired through many avenues by many people. Many data submission activities involve intensive manual processes. During the submission process, data end up on varied storage devices. The situation can easily become chaotic. Collecting information on the status of pending data sets is arduous. For data providers, the submission process can be inconsistent and confusing. Scientists generally provide data from previous projects, and archival can be a low priority. Incomplete or poor documentation accompanies many data sets. However, complicated questionnaires deter busy data providers. At the ORNL DAAC, we have semi-automated the data set submission process to create a uniform data product and provide a consistent data provider experience. The formalized workflow makes archival faster for the data center and data set submission easier for data providers. Software modules create a flexible, reusable submission package. Formalized data set submission provides several benefits to the data center. A single data upload area provides one point of entry and ensures data are stored in a consistent location. A central dashboard records pending data set submissions in a single table and simplifies reporting. Flexible role management allows team members to readily coordinate and increases efficiency. Data products and metadata become uniform and easily maintained. As data and metadata standards change, modules can be modified or re-written without affecting workflow. While each data center has unique challenges, the data ingestion process is generally the same: get data from the provider, scientist, or project and capture metadata pertinent to that data. The ORNL DAAC data set submission workflow and software modules can be reused entirely or in part by other data centers looking for a data set submission solution. These data set submission modules will be available on NASA's Earthdata Code

  13. Marshall Space Flight Center Technology Investments Overview (United States)

    Tinker, Mike


    NASA is moving forward with prioritized technology investments that will support NASA's exploration and science missions, while benefiting other Government agencies and the U.S. aerospace enterprise. center dotThe plan provides the guidance for NASA's space technology investments during the next four years, within the context of a 20-year horizon center dotThis plan will help ensure that NASA develops technologies that enable its 4 goals to: 1.Sustain and extend human activities in space, 2.Explore the structure, origin, and evolution of the solar system, and search for life past and present, 3.Expand our understanding of the Earth and the universe and have a direct and measurable impact on how we work and live, and 4.Energize domestic space enterprise and extend benefits of space for the Nation.

  14. Telemetry Computer System at Wallops Flight Center (United States)

    Bell, H.; Strock, J.


    This paper describes the Telemetry Computer System in operation at NASA's Wallops Flight Center for real-time or off-line processing, storage, and display of telemetry data from rockets and aircraft. The system accepts one or two PCM data streams and one FM multiplex, converting each type of data into computer format and merging time-of-day information. A data compressor merges the active streams, and removes redundant data if desired. Dual minicomputers process data for display, while storing information on computer tape for further processing. Real-time displays are located at the station, at the rocket launch control center, and in the aircraft control tower. The system is set up and run by standard telemetry software under control of engineers and technicians. Expansion capability is built into the system to take care of possible future requirements.

  15. Offshore Space Center (offshore launch site) (United States)

    Harvey, D. G.


    Any activity requiring the development of the HLLV can benefit by operations from an offshore space center (OSC) since operating near the equator provides a twenty percent increase in payload in an ecliptic plan orbit. Some OSC concepts considered include a moored floating (semisubmersible) design, a stationary design supported by fixed piles, and a combination of these two. The facility supports: a 15,000 foot long, 300 foot wide runway, designed to accommodate a two staged winged launch vehicle, with a one million pound payload capacity to low earth orbit; an industrial area for HLLV maintenance; an airport terminal, control and operation center, and observation tower; liquid hydrogen and liquid oxygen production and storage, and fuel storage platforms; a power generation station, docks with an unloading area; two separate launch sites; and living accommodations for 10,000 people. Potential sites include the Paramount Seamount in the Pacific Ocean off the north coast of South America. Cost estimates are considered.

  16. Industrial Assessment Center Program Impact Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Martin, M.A.


    This report presents the results of an evaluation of the U.S. Department of Energy's Industrial Assessment Center (IAC) Program. The purpose of this program is to conduct energy, waste, and productivity assessments for small to medium-sized industrial firms. Assessments are conducted by 30 university-based industrial assessment centers. The purpose of this project was to evaluate energy and cost savings attributable to the assessments, the trained alumni, and the Websites sponsored by this program. How IAC assessments, alumni, and Web-based information may influence industrial energy efficiency decision making was also studied. It is concluded that appreciable energy and cost savings may be attributed to the IAC Program and that the IAC Program has resulted in more active and improved energy-efficiency decision making by industrial firms.

  17. Shopping Malls - ShoppingCenters (United States)

    NSGIC GIS Inventory (aka Ramona) — Collected from a variety of sources both commercial and internal, this layer represents shopping center locations within Volusia County and is maintained by the...

  18. Clean Energy Solutions Center Services

    Energy Technology Data Exchange (ETDEWEB)


    The Solutions Center offers no-cost expert policy assistance, webinars and training forums, clean energy policy reports, data, and tools provided in partnership with more than 35 leading international and regional clean energy organizations.

  19. Center for Creative Studies, Detroit (United States)

    AIA Journal, 1976


    One of the ten buildings chosen to receive 1976 AIA honor awards, the arts center houses the departments of sculpture, painting, graphics, advertising art, photography, and industrial design. (Author/MLF)

  20. Electricity Infrastructure Operations Center (EIOC) (United States)

    Federal Laboratory Consortium — The Electricity Infrastructure Operations Center (EIOC) at PNNL brings together industry-leading software, real-time grid data, and advanced computation into a fully...