WorldWideScience

Sample records for activity centers

  1. Nucleation on active centers in confined volumes

    OpenAIRE

    Kožíšek, Zdeněk; Hikosaka, Masamichi; Okada, Kiyoka; Demo, Pavel

    2012-01-01

    Kinetic equations describing nucleation on active centers are solved numerically to determine the number of supercritical nuclei, nucleation rate, and the number density of nuclei for formation both of droplets from vapor and also crystalline phase from vapor, solution, and melt. Our approach follows standard nucleation model, when the exhaustion of active centers is taken into account via the boundary condition, and thus no additional equation (expressing exhaustion of active centers) is nee...

  2. Scientific activities 1980 Nuclear Research Center ''Democritos''

    International Nuclear Information System (INIS)

    The scientific activities and achievements of the Nuclear Research Center Democritos for the year 1980 are presented in the form of a list of 76 projects giving title, objectives, responsible of each project, developed activities and the pertaining lists of publications. The 16 chapters of this work cover the activities of the main Divisions of the Democritos NRC: Electronics, Biology, Physics, Chemistry, Health Physics, Reactor, Scientific Directorate, Radioisotopes, Environmental Radioactivity, Soil Science, Computer Center, Uranium Exploration, Medical Service, Technological Applications, Radioimmunoassay and Training. (N.C.)

  3. Activities of the NEDO information center

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    Under the situation where items of information related to energy and industrial technologies (including environmental technologies) are diversified and internationalized, the NEDO Information Center opens its book and data rooms, performs database service and information exchange activities with other countries, and issues information journals. These activities are intended to respond accurately and quickly to users` information needs. This paper reports the result of operations during fiscal 1994. Retained and provided for public reading at the Center are 2,200 reports on results of research and development works having been carried out by NEDO, 3,800 books and data published inside and outside Japan mainly on new energies, and 190 kinds of periodical publications. The first nationwide geothermal result charts are also reproduced and sold. Technological literature and information prepared by IEA which have been obtained based on the energy technological data exchange treaty and the implementation treaty on establishment of IEA coal research have been recorded as the NEDO-EDBS and offered on line. This paper also introduces the optical databases. The agreement on the IEA Information Centers for the Analysis and Dissemination of Demonstrated Energy Technologies (CADDET) is also available. Descriptions are given also on activities of the Greenhouse Gas Technology Information Exchange (GREENTIE).

  4. Training activities at the EPRI NDE Center

    International Nuclear Information System (INIS)

    The Electric Power Research Institute (EPRI), through its Nondestructive Examination (NDE) Center in Charlotte, North Carolina, has identified two specific categories of NDE training to best serve the industry's need for enhanced personnel qualification programs. These categories include in-service inspection (ISI) training and technical skills training. The ISI training provides operator training in new NDE technology areas that are ready for field application. The technical skills training is developed as part of a long-range plan to support all basic NDE methods typical to the electric power industry. The need for specific training and better documentation of NDE personnel qualifications is becoming more evident. ASME Section XI requirements for the qualification and certification of visual examiners and the recognition by the US Nuclear Regulatory Commission (NRC) of the importance of the ultrasonic (UT) operator in finding intergranular stress corrosion cracking (IGSCC) are two of the major issues being addressed by the training task of the EPRI NDE Center. The overall intent of the center's training is to meet the most critical utility needs with quality training that can be used by the trainee's employer as a part of their certification of that individual. To do this, the center has organized and activated a carefully maintained documentation and records systems built around the continuing education unit

  5. Research on the Activities of Urban Greenery Centers

    OpenAIRE

    Yamamoto, Satoshi; MASUDA, Noboru; SHIMOMURA, Yasuhiko; ABE, Daishu

    1992-01-01

    In this research, urban greenery centers are looked at as environmental education facilities for urban residents. The role of greenery centers in environmental education is considered by investigating their present activities. It was found that activities are centered on gardening classes and plant exhibits. Greenery centers are therefore fulfilling the original role set out for them by aiding the diffusion of urban greenery and enlightening the populace. As environmental concerns continue to...

  6. Supporting Human Activities - Exploring Activity-Centered Computing

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Bardram, Jakob

    2002-01-01

    In this paper we explore an activity-centered computing paradigm that is aimed at supporting work processes that are radically different from the ones known from office work. Our main inspiration is healthcare work that is characterized by an extreme degree of mobility, many interruptions, ad......-hoc collaboration based on shared material, and organized in terms of well-defined, recurring, work activities. We propose that this kind of work can be supported by a pervasive computing infrastructure together with domain-specific services, both designed from a perspective where work activities are first class...... objects. We also present an exploratory prototype design and first implementation and present some initial results from evaluations in a healthcare environment....

  7. Increased physical activity, physician recommendation, and senior center participation

    OpenAIRE

    Swan, James H.; Keith Turner; Shilpa Shashidhara; David Sanders

    2013-01-01

    Physical activity is a recognized preventive health measure for seniors and an important focus for senior centers. This paper employs the Andersen Behavioral Model to explore increased physical activity and participation in three types of senior center activities: physical fitness, dance/aerobic classes, and chair exercises. Data were collected in 2006 on 798 and in 2007 on 742 participants at 21 multipurpose senior centers in a large urban county. Logistic regression analysis (PROC RLOG...

  8. Activity report of Computing Research Center

    Energy Technology Data Exchange (ETDEWEB)

    1997-07-01

    On April 1997, National Laboratory for High Energy Physics (KEK), Institute of Nuclear Study, University of Tokyo (INS), and Meson Science Laboratory, Faculty of Science, University of Tokyo began to work newly as High Energy Accelerator Research Organization after reconstructing and converting their systems, under aiming at further development of a wide field of accelerator science using a high energy accelerator. In this Research Organization, Applied Research Laboratory is composed of four Centers to execute assistance of research actions common to one of the Research Organization and their relating research and development (R and D) by integrating the present four centers and their relating sections in Tanashi. What is expected for the assistance of research actions is not only its general assistance but also its preparation and R and D of a system required for promotion and future plan of the research. Computer technology is essential to development of the research and can communize for various researches in the Research Organization. On response to such expectation, new Computing Research Center is required for promoting its duty by coworking and cooperating with every researchers at a range from R and D on data analysis of various experiments to computation physics acting under driving powerful computer capacity such as supercomputer and so forth. Here were described on report of works and present state of Data Processing Center of KEK at the first chapter and of the computer room of INS at the second chapter and on future problems for the Computing Research Center. (G.K.)

  9. Adult Basic Learning in an Activity Center: A Demonstration Approach.

    Science.gov (United States)

    Metropolitan Adult Education Program, San Jose, CA.

    Escuela Amistad, an activity center in San Jose, California, is now operating at capacity, five months after its origin. Average daily attendance has been 125 adult students, 18-65, most of whom are females of Mexican-American background. Activities and services provided by the center are: instruction in English as a second language, home…

  10. Software package as an information center product. [Activities of Argonne Code Center

    Energy Technology Data Exchange (ETDEWEB)

    Butler, M. K.

    1977-01-01

    The Argonne Code Center serves as a software exchange and information center for the U.S. Energy Research and Development Administration and the Nuclear Regulatory Commission. The goal of the Center's program is to provide a means for sharing of software among agency offices and contractors, and for transferring computing applications and technology, developed within the agencies, to the information-processing community. A major activity of the Code Center is the acquisition, review, testing, and maintenance of a collection of software--computer systems, applications programs, subroutines, modules, and data compilations--prepared by agency offices and contractors to meet programmatic needs. A brief review of the history of computer program libraries and software sharing is presented to place the Code Center activity in perspective. The state-of-the-art discussion starts off with an appropriate definition of the term software package, together with descriptions of recommended package contents and the Carter's package evaluation activity. An effort is made to identify the various users of the product, to enumerate their individual needs, to document the Center's efforts to meet these needs and the ongoing interaction with the user community. Desirable staff qualifications are considered, and packaging problems, reviewed. The paper closes with a brief look at recent developments and a forecast of things to come. 2 tables. (RWR)

  11. CONGESTION AS A RESULT OF SCHOOL AND SHOPPING CENTER ACTIVITY

    Directory of Open Access Journals (Sweden)

    Meike Kumaat

    2015-12-01

    Full Text Available Development of land use in public facilities such as shopping center and school gives an impact on transportation problem in Manado City, North Sulawesi.  To determine factors which have causal relationship with congestion  as a result of school and shopping center activity then it need to be assessed and studied.  Descriptive study with observational survey was used in this study. The study ran Structural Equation Modelling (SEM by using AMOS program. Estimated method was used to calculate sample size then found 300 repondents, comprised : visitors and mall managers, school visitors, parents, school managers, Public Works department, and urban planning department .The study yielded a statistically significant correlation between  school and shopping center activity with congestion s. The result  indicated that school activity was positively related to congestion with p value  at p=0,000 (p ≤ 0,05. Shopping center activity was positively related to congestion with p value  at p=0,000 (p ≤ 0,05. The closer proximity from school to shooping center will causes severe traffic congestion. The relationship between school facility with proximity was found in p value at  p=0,000 (p ≤ 0,05 . The relationship between shopping center facility with proximity was found in p value at  p= 0,020 (p ≤ 0,05. While, the relationship between proximity with congestion was p= 0,008 (p ≤ 0,05. Monastery school and Mega Mall activity were affecting congestion because a closer proximity of two facilities. This indicates that the occurence of traffic congestion in Monastery School  may be dependent on existence of  Piere Tendean road link

  12. SOCIOCULTURAL ACTIVITY YOUTH CENTERS: THE SPIRITUAL AND MORAL CONTEXT

    Directory of Open Access Journals (Sweden)

    Svetlana Petrovna Shtumpf

    2015-12-01

    Full Text Available The reality of life today is set the challenge and create the preconditions for youth associations in the diverse groups and movements. Such unity is a unifying factor in shaping the collective consciousness of the group, the basic concepts of the spiritual and moral values of shared responsibility on the individual, group and societal levels. In this work the motives of familiarizing young people to the activities of such organizations, the specifics of the youth socialization issues of leadership in them. Peculiarities of organizational core movement – the youth center, its structural composition, mechanism of operation, providing the main areas of work - organizational, methodical and information. Is proposed the collection practices, subjects, activities implemented in the work of youth organizations. We discuss the possible risks related to the status of the leader and worker center, with a possible negative impact of group on the individual participant. Attention is drawn to the importance of personal competences of worker of youth centers.

  13. STUDY OF PASSIVE DIDACTIC TEACHER CENTERED APPROACH AND AN ACTIVE STUDENT CENTERED APPROACH IN TEACHING ANATOMY

    Directory of Open Access Journals (Sweden)

    Sharadkumar Pralhad Sawant

    2015-09-01

    Full Text Available The importance of Anatomy in undergraduate medical education cannot be adequately emphasised. For doctors, the human body is the focus of investigation and intervention on a daily basis; for this reason, the study of anatomy in some form, will continue to be essential to safe medical practice. It is necessary for core knowledge of anatomy to be assimilated by all doctors in order to practice medicine safely. It may be true that most doctors do not need to dissect a cadaver or study a prosection in order to practice, but if they do, it can improve their understanding and this surely has to be of benefit both for the safety of the patient and satisfaction of the doctor as a professional. Teacher-centered typically refers to learning situations in which the teacher asserts control over the material that students study. In contrast,to teacher centered learning, student-centered typically refers to forms of instruction that, for example, give students opportunities to lead learning activities, participate more actively in discussions, design their own learning projects, explore topics that interest them, and generally contribute to the design of their own course of study. Additionally, student-centered instruction is often associated with classrooms that feature desks arranged in circles or small groups (rather than rows of desks that face the teacher, with “self-guided” or “self-paced” learning, or with learning experiences that occur outside of traditional classroom settings. Anatomy teaching has undergone major changes due to time constraints and the rapid advances in computer technology. Also there has been a shift a teaching methodologies from a passive didactic teacher- centered approach to an active student - centered approach. Conclusion: We should develop and implement an instructional design that focuses on incorporating active-learning and student-centered pedagogy into what is previously a traditional lecture-based course. These

  14. Land processes distributed active archive center product lifecycle plan

    Science.gov (United States)

    Daucsavage, John C.; Bennett, Stacie D.

    2014-01-01

    The U.S. Geological Survey (USGS) Earth Resources Observation and Science (EROS) Center and the National Aeronautics and Space Administration (NASA) Earth Science Data System Program worked together to establish, develop, and operate the Land Processes (LP) Distributed Active Archive Center (DAAC) to provide stewardship for NASA’s land processes science data. These data are critical science assets that serve the land processes science community with potential value beyond any immediate research use, and therefore need to be accounted for and properly managed throughout their lifecycle. A fundamental LP DAAC objective is to enable permanent preservation of these data and information products. The LP DAAC accomplishes this by bridging data producers and permanent archival resources while providing intermediate archive services for data and information products.

  15. Data Information for Global Change Studies: NASA's Distributed Active Archive Centers and Cooperating Data Centers

    Science.gov (United States)

    2000-01-01

    The Earth Observing System (EOS) is an integral part of the National Aeronautics and Space Administration's (NASA's) Earth Science Enterprise (ESE). ESE is a long-term global change research program designed to improve our understanding of the Earth's interrelated processes involving the atmosphere, oceans, land surfaces, and polar regions. Data from EOS instruments and other Earth science measurement systems are useful in understanding the causes and processes of global climate change and the consequences of human activities. The EOS Data and Information System (EOSDIS) provides a structure for data management and user services for products derived from EOS satellite instruments and other NASA Earth science data. Within the EOSDIS framework, the Distributed Active Archive Centers (DAACs) have been established to provide expertise in one or more Earth science disciplines. The DAACs and cooperating data centers provide data and information services to support the global change research community. Much of the development of the DAACs has been in anticipation of the enormous amount of data expected from EOS instruments to be launched within the next two decades. Terra, the EOS flagship launched in December 1999, is the first of a series of EOS satellites to carry several instruments with multispectral capabilities. Some data products from these instruments are now available from several of the DAACs. These and other data products can be ordered through the EOS Data Gateway (EDG) and DAAC-specific online ordering systems.

  16. GHRC: NASAs Hazardous Weather Distributed Active Archive Center

    Science.gov (United States)

    Ramachandran, Rahul; Bugbee, Kaylin

    2016-01-01

    The Global Hydrology Resource Center (GHRC; ghrc.nsstc.nasa.gov) is one of NASA's twelve Distributed Active Archive Centers responsible for providing access to NASA's Earth science data to users worldwide. Each of NASA's twelve DAACs focuses on a specific science discipline within Earth science, provides data stewardship services and supports its research community's needs. Established in 1991 as the Marshall Space Flight Center DAAC and renamed GHRC in 1997, the data center's original mission focused on the global hydrologic cycle. However, over the years, data holdings, tools and expertise of GHRC have gradually shifted. In 2014, a User Working Group (UWG) was established to review GHRC capabilities and provide recommendations to make GHRC more responsive to the research community's evolving needs. The UWG recommended an update to the GHRC mission, as well as a strategic plan to move in the new direction. After a careful and detailed analysis of GHRC's capabilities, research community needs and the existing data landscape, a new mission statement for GHRC has been crafted: to provide a comprehensive active archive of both data and knowledge augmentation services with a focus on hazardous weather, its governing dynamical and physical processes, and associated applications. Within this broad mandate, GHRC will focus on lightning, tropical cyclones and storm-induced hazards through integrated collections of satellite, airborne, and in-situ data sets. The new mission was adopted at the recent 2015 UWG meeting. GHRC will retain its current name until such time as it has built substantial data holdings aligned with the new mission.

  17. 75 FR 49946 - National Drug Intelligence Center: Agency Information Collection Activities: Proposed Extension...

    Science.gov (United States)

    2010-08-16

    ... National Drug Intelligence Center: Agency Information Collection Activities: Proposed Extension With Change... Response System. The United States Department of Justice (DOJ), National Drug Intelligence Center (NDIC... Intelligence Center, Fifth Floor, 319 Washington Street, Johnstown, PA 15901. Written comments and...

  18. The 1988 activity report of the Strasbourg Nuclear Research Center

    International Nuclear Information System (INIS)

    The 1988 activity report of the Strasbourg Nuclear Research Center (France), concerning the Vivitron project, is presented. In 1988, the main Vivitron operation was the assembly of the generator structure. Problems related to the beam were analyzed by means of extensive measurements on ion sources beam emittances and beam transmissions through the MP Tandem. This report includes the following topics: the description of the project different development steps; scientific and technical work carried out by the Vivitron team; the reports of the Vivitron budget and planning meetings, as well as congress contributions and published papers

  19. The Land Processes Distributed Active Archive Center (LP DAAC)

    Science.gov (United States)

    Golon, Danielle K.

    2016-10-03

    The Land Processes Distributed Active Archive Center (LP DAAC) operates as a partnership with the U.S. Geological Survey and is 1 of 12 DAACs within the National Aeronautics and Space Administration (NASA) Earth Observing System Data and Information System (EOSDIS). The LP DAAC ingests, archives, processes, and distributes NASA Earth science remote sensing data. These data are provided to the public at no charge. Data distributed by the LP DAAC provide information about Earth’s surface from daily to yearly intervals and at 15 to 5,600 meter spatial resolution. Data provided by the LP DAAC can be used to study changes in agriculture, vegetation, ecosystems, elevation, and much more. The LP DAAC provides several ways to access, process, and interact with these data. In addition, the LP DAAC is actively archiving new datasets to provide users with a variety of data to study the Earth.

  20. Carbon Nanotube Activities at NASA-Johnson Space Center

    Science.gov (United States)

    Arepalli, Sivaram

    2006-01-01

    Research activities on carbon nanotubes at NASA-Johnson Space Center include production, purification, characterization and their applications for human space flight. In-situ diagnostics during nanotube production by laser oven process include collection of spatial and temporal data of passive emission and laser induced fluorescence from C2, C3 and Nickel atoms in the plume. Details of the results from the "parametric study" of the pulsed laser ablation process indicate the effect of production parameters including temperature, buffer gas, flow rate, pressure, and laser fluence. Improvement of the purity by a variety of steps in the purification process is monitored by characterization techniques including SEM, TEM, Raman, UV-VIS-NIR and TGA. A recently established NASA-JSC protocol for SWCNT characterization is undergoing revision with feedback from nanotube community. Efforts at JSC over the past five years in composites have centered on structural polymednanotube systems. Recent activities broadened this focus to multifunctional materials, supercapacitors, fuel cells, regenerable CO2 absorbers, electromagnetic shielding, radiation dosimetry and thermal management systems of interest for human space flight. Preliminary tests indicate improvement of performance in most of these applications because of the large surface area as well as high electrical and thermal conductivity exhibited by SWCNTs.

  1. Regulating the nitrite reductase activity of myoglobin by redesigning the heme active center.

    Science.gov (United States)

    Wu, Lei-Bin; Yuan, Hong; Gao, Shu-Qin; You, Yong; Nie, Chang-Ming; Wen, Ge-Bo; Lin, Ying-Wu; Tan, Xiangshi

    2016-07-01

    Heme proteins perform diverse functions in living systems, of which nitrite reductase (NIR) activity receives much attention recently. In this study, to better understand the structural elements responsible for the NIR activity, we used myoglobin (Mb) as a model heme protein and redesigned the heme active center, by introducing one or two distal histidines, and by creating a channel to the heme center with removal of the native distal His64 gate (His to Ala mutation). UV-Vis kinetic studies, combined with EPR studies, showed that a single distal histidine with a suitable position to the heme iron, i.e., His43, is crucial for nitrite (NO2(-)) to nitric oxide (NO) reduction. Moreover, creation of a water channel to the heme center significantly enhanced the NIR activity compared to the corresponding mutant without the channel. In addition, X-ray crystallographic studies of F43H/H64A Mb and its complexes with NO2(-) or NO revealed a unique hydrogen-bonding network in the heme active center, as well as unique substrate and product binding models, providing valuable structural information for the enhanced NIR activity. These findings enriched our understanding of the structure and NIR activity relationship of heme proteins. The approach of creating a channel in this study is also useful for rational design of other functional heme proteins. PMID:27108710

  2. 77 FR 20887 - Proposed Information Collection (National Acquisition Center Customer Response Survey) Activity...

    Science.gov (United States)

    2012-04-06

    ... solicits comments on the information needed to measure customer satisfaction with delivered products and... AFFAIRS Proposed Information Collection (National Acquisition Center Customer Response Survey) Activity...: Department of Veterans Affairs (VA) National Acquisition Center Customer Response Survey, VA Form 0863....

  3. Carbon Dioxide Information Analysis Center: FY 1992 activities

    Energy Technology Data Exchange (ETDEWEB)

    Cushman, R.M. [Oak Ridge National Lab., TN (United States). Carbon Dioxide Information Analysis Center; Stoss, F.W. [Tennessee Univ., Knoxville, TN (United States). Energy, Environment and Resources Center

    1993-03-01

    During the course of a fiscal year, Oak Ridge National Laboratory`s Carbon Dioxide Information Analysis Center (CDIAC) distributes thousands of specialty publications-numeric data packages (NDPs), computer model packages (CMPs), technical reports, public communication publications, newsletters, article reprints, and reference books-in response to requests for information related to global environmental issues, primarily those pertaining to climate change. CDIACs staff also provides technical responses to specific inquiries related to carbon dioxide (CO{sub 2}), other trace gases, and climate. Hundreds of referrals to other researchers, policy analysts, information specialists, or organizations are also facilitated by CDIAC`s staff. This report provides an account of the activities accomplished by CDIAC during the period October 1, 1991 to September 30, 1992. An organizational overview of CDIAC and its staff is supplemented by a detailed description of inquiries received and CDIAC`s response to those inquiries. As analysis and description of the preparation and distribution of numeric data packages, computer model packages, technical reports, newsletters, fact sheets, specialty publications, and reprints is provided. Comments and descriptions of CDIAC`s information management systems, professional networking, and special bilateral agreements are also described.

  4. Carbon Dioxide Information Analysis Center: FY 1991 activities

    Energy Technology Data Exchange (ETDEWEB)

    Cushman, R.M.; Stoss, F.W.

    1992-06-01

    During the course of a fiscal year, Oak Ridge National Laboratory`s Carbon Dioxide Information Analysis Center (CDIAC) distributes thousands of specially publications-numeric data packages (NDPs), computer model packages (CMPs), technical reports, public communication publications, newsletters, article reprints, and reference books-in response to requests for information related to global environmental issues, primarily those pertaining to climate change. CDIAC`s staff also provides technical responses to specific inquiries related to carbon dioxide (CO{sub 2}), other trace gases, and climate. Hundreds of referrals to other researchers, policy analysts, information specialists, or organizations are also facilitated by CDIAC`s staff. This report provides an account of the activities accomplished by CDIAC during the period October 1, 1990 to September 30, 1991. An organizational overview of CDIAC and its staff is supplemented by a detailed description of inquiries received and CDIAC`s response to those inquiries. An analysis and description of the preparation and distribution of numeric data packages, computer model packages, technical reports, newsletters, factsheets, specially publications, and reprints is provided. Comments and descriptions of CDIAC`s information management systems, professional networking, and special bilateral agreements are also described.

  5. Carbon Dioxide Information Analysis Center: FY 1991 activities

    Energy Technology Data Exchange (ETDEWEB)

    Cushman, R.M.; Stoss, F.W.

    1992-06-01

    During the course of a fiscal year, Oak Ridge National Laboratory's Carbon Dioxide Information Analysis Center (CDIAC) distributes thousands of specially publications-numeric data packages (NDPs), computer model packages (CMPs), technical reports, public communication publications, newsletters, article reprints, and reference books-in response to requests for information related to global environmental issues, primarily those pertaining to climate change. CDIAC's staff also provides technical responses to specific inquiries related to carbon dioxide (CO{sub 2}), other trace gases, and climate. Hundreds of referrals to other researchers, policy analysts, information specialists, or organizations are also facilitated by CDIAC's staff. This report provides an account of the activities accomplished by CDIAC during the period October 1, 1990 to September 30, 1991. An organizational overview of CDIAC and its staff is supplemented by a detailed description of inquiries received and CDIAC's response to those inquiries. An analysis and description of the preparation and distribution of numeric data packages, computer model packages, technical reports, newsletters, factsheets, specially publications, and reprints is provided. Comments and descriptions of CDIAC's information management systems, professional networking, and special bilateral agreements are also described.

  6. Hybrid vision activities at NASA Johnson Space Center

    Science.gov (United States)

    Juday, Richard D.

    1990-01-01

    NASA's Johnson Space Center in Houston, Texas, is active in several aspects of hybrid image processing. (The term hybrid image processing refers to a system that combines digital and photonic processing). The major thrusts are autonomous space operations such as planetary landing, servicing, and rendezvous and docking. By processing images in non-Cartesian geometries to achieve shift invariance to canonical distortions, researchers use certain aspects of the human visual system for machine vision. That technology flow is bidirectional; researchers are investigating the possible utility of video-rate coordinate transformations for human low-vision patients. Man-in-the-loop teleoperations are also supported by the use of video-rate image-coordinate transformations, as researchers plan to use bandwidth compression tailored to the varying spatial acuity of the human operator. Technological elements being developed in the program include upgraded spatial light modulators, real-time coordinate transformations in video imagery, synthetic filters that robustly allow estimation of object pose parameters, convolutionally blurred filters that have continuously selectable invariance to such image changes as magnification and rotation, and optimization of optical correlation done with spatial light modulators that have limited range and couple both phase and amplitude in their response.

  7. CD83 Modulates B Cell Activation and Germinal Center Responses.

    Science.gov (United States)

    Krzyzak, Lena; Seitz, Christine; Urbat, Anne; Hutzler, Stefan; Ostalecki, Christian; Gläsner, Joachim; Hiergeist, Andreas; Gessner, André; Winkler, Thomas H; Steinkasserer, Alexander; Nitschke, Lars

    2016-05-01

    CD83 is a maturation marker for dendritic cells. In the B cell lineage, CD83 is expressed especially on activated B cells and on light zone B cells during the germinal center (GC) reaction. The function of CD83 during GC responses is unclear. CD83(-/-) mice have a strong reduction of CD4(+) T cells, which makes it difficult to analyze a functional role of CD83 on B cells during GC responses. Therefore, in the present study we generated a B cell-specific CD83 conditional knockout (CD83 B-cKO) model. CD83 B-cKO B cells show defective upregulation of MHC class II and CD86 expression and impaired proliferation after different stimuli. Analyses of GC responses after immunization with various Ags revealed a characteristic shift in dark zone and light zone B cell numbers, with an increase of B cells in the dark zone of CD83 B-cKO mice. This effect was not accompanied by alterations in the level of IgG immune responses or by major differences in affinity maturation. However, an enhanced IgE response was observed in CD83 B-cKO mice. Additionally, we observed a strong competitive disadvantage of CD83-cKO B cells in GC responses in mixed bone marrow chimeras. Furthermore, infection of mice with Borrelia burgdorferi revealed a defect in bacterial clearance of CD83 B-cKO mice with a shift toward a Th2 response, indicated by a strong increase in IgE titers. Taken together, our results show that CD83 is important for B cell activation and modulates GC composition and IgE Ab responses in vivo. PMID:26983787

  8. 77 FR 70211 - Agency Information Collection Activities (Call Center Satisfaction Survey) Under OMB Review

    Science.gov (United States)

    2012-11-23

    ... AFFAIRS Agency Information Collection Activities (Call Center Satisfaction Survey) Under OMB Review AGENCY....'' SUPPLEMENTARY INFORMATION: Title: VBA Call Center Satisfaction Survey. OMB Control Number: 2900-0744. Type of... Veterans; (2) determine what to do to improve the call center experience; and (3) serve to guide...

  9. Activities and Products at IVS combination center at BKG

    Science.gov (United States)

    Bachmann, S.; Lösler, M.

    2013-08-01

    The IVS combination center is primarily responsible to provide rapid EOP products based on observation campaigns twice a week and a long-term EOP series which is updated four times a year. Besides EOP products, methods and analysis of combined station coordinates and source positions are evolving and new products are developed in order to expand the range of combined VLBI products. Within the last year the combination center continuously worked on several improvements and refinements of the combination procedure: outlier test have been improved, the detection of unsuitable sessions in order to improve the stability of the results, the modeling of station coordinates of the reference frame generation and the data presentation on the combination centers website. Besides the routine combination of 24h VLBI sessions, several other projects have been developed, e.g. the preparation of the latest VLBI reference frame (VTRF) including the calculation of station height variations and baseline lengths generation derived by the combination of station coordinates. The combination center is furthermore intensely working on the combination of source coordinates and on providing user friendly online analysis tools on the combination centers website in order to meet the user requirements.

  10. Learning by Doing: Engaging Students through Learner-Centered Activities

    Science.gov (United States)

    Smart, Karl L.; Csapo, Nancy

    2007-01-01

    With a shift of focus from teaching to learning in higher education, teachers often look for strategies to involve students actively in the learning process, especially since numerous studies have demonstrated that a student's active involvement in the learning process enhances learning. Active learning has resulted in positive learning outcomes.…

  11. Recent Activities of Tsukuba Correlator/Analysis Center

    Science.gov (United States)

    Kokado, K.; Kurihara, S.; Kawabata, R.; Nozawa, K.

    2012-12-01

    The Geospatial Information Authority of Japan (GSI) has been a member of IVS and taken charge of a Network Station and an IVS Correlator since 1998. In addition, GSI became an IVS Operational Analysis Center in January 2010.The Tsukuba Correlator takes charge of correlation work for approximately 100 IVS-INT02 (INT2) sessions and 10 Japanese domestic sessions every year. In 2011, the number of INT2 sessions dramatically increased, because INT2 sessions were observed twice a day during the weekend from April 2011 to January 2012 due to the change in position of the Tsukuba 32-m antenna by the 2011 earthquake off the Pacific coast of Tohoku. The role of the Tsukuba VLBI Analysis Center is to produce ultra-rapid dUT1 measurements, sessions with the goal of obtaining a dUT1 solution within 30 minutes after the end of the observation session. The data processing system at the Tsukuba Correlator and Analysis Center was dramatically improved to achieve rapid data processing. It enabled us to shorten the data processing time to one-sixth and to process the IVS VLBI data in near real-time. In 2011, we processed the ultra-rapid dUT1 measurements with the Onsala or Wettzell stations from INT2 sessions or IVS 24-hour sessions, such as R1, RD or T2 sessions. The most successful sessions for ultra-rapid dUT1 measurement was the CONT11 sessions which were a campaign of 15 days of continuous VLBI sessions. During these sessions, we succeeded in estimating continuous dUT1 solutions in near real-time for 15 days.

  12. Recent Activities on the Embrace Space Weather Regional Warning Center: the New Space Weather Data Center

    Science.gov (United States)

    Denardini, Clezio Marcos; Dal Lago, Alisson; Mendes, Odim; Batista, Inez S.; SantAnna, Nilson; Gatto, Rubens; Takahashi, Hisao; Costa, D. Joaquim; Banik Padua, Marcelo; Campos Velho, Haroldo

    2016-07-01

    On August 2007 the National Institute for Space Research started a task force to develop and operate a space weather program, which is known by the acronyms Embrace that stands for the Portuguese statement "Estudo e Monitoramento BRAasileiro de Clima Espacial" Program (Brazilian Space Weather Study and Monitoring program). The mission of the Embrace/INPE program is to monitor the Solar-Terrestrial environment, the magnetosphere, the upper atmosphere and the ground induced currents to prevent effects on technological and economic activities. The Embrace/INPE system monitors the physical parameters of the Sun-Earth environment, such as Active Regions (AR) in the Sun and solar radiation by using radio telescope, Coronal Mass Ejection (CME) information by satellite and ground-based cosmic ray monitoring, geomagnetic activity by the magnetometer network, and ionospheric disturbance by ionospheric sounders and using data collected by four GPS receiver network, geomagnetic activity by a magnetometer network, and provides a forecasting for Total Electronic Content (TEC) - 24 hours ahead - using a version of the SUPIM model which assimilates the two latter data using nudging approach. Most of these physical parameters are daily published on the Brazilian space weather program web portal, related to the entire network sensors available. Regarding outreach, it has being published a daily bulletin in Portuguese and English with the status of the space weather environment on the Sun, the Interplanetary Medium and close to the Earth. Since December 2011, all these activities are carried out at the Embrace Headquarter, a building located at the INPE's main campus. Recently, a comprehensive data bank and an interface layer are under commissioning to allow an easy and direct access to all the space weather data collected by Embrace through the Embrace web Portal. The information being released encompasses data from: (a) the Embrace Digisonde Network (Embrace DigiNet) that monitors

  13. Daily activities and living at a Therapeutic Residential Care Center

    Directory of Open Access Journals (Sweden)

    Luciane Prado Kantorki

    2014-12-01

    Full Text Available This study describes and analyzes day-to-day issues in a Therapeutic Residential Care Center and the daily life characteristics of its residents. This case study was conducted in Caxias do Sul, based on an evaluation of the fourth generation together with a Methodology for Analyzing Everyday Life Networks. The following categories emerged: possibilities in the territory, participation and flexibility in household tasks, situations that mark living, employees who are mediators in conflict resolution, staff committed to the resident, freedom as a therapeutic tool, difficulties in daily life, and building of alliances. This study helped to get to know the structure of everyday life experienced by the residents, identifying some difficulties they face and the mechanisms used to overcome them, in addition to noticing that the professionals can be instrumental in strengthening a daily living that can be pluralized, busy, and enriched, while still respecting the uniqueness of each resident. doi: 10.5216/ree.v16i4.22923.

  14. Robotics-Centered Outreach Activities: An Integrated Approach

    Science.gov (United States)

    Ruiz-del-Solar, Javier

    2010-01-01

    Nowadays, universities are making extensive efforts to attract prospective students to the fields of electrical, electronic, and computer engineering. Thus, outreach is becoming increasingly important, and activities with schoolchildren are being extensively carried out as part of this effort. In this context, robotics is a very attractive and…

  15. Annual activities report of Brazilian Aerospace Technical Center -CTA/IEAv - 1989

    International Nuclear Information System (INIS)

    This document reports the research activities on nuclear physics and reactors physics and engineering in the Brazilian Aerospace Technical Center/Advanced Studies Institute, Sao Paulo State, in the year of 1989

  16. Beyond active learning: a case study of teaching practices in an occupation-centered curriculum.

    Science.gov (United States)

    Hooper, Barbara

    2006-01-01

    Although occupation-centered curricula are highly promoted, the teaching processes that convey such designs remain unclear. This case study elucidated occupation-centered teaching practices. Interview and observational data were collected over 8 weeks, and analysis involved coding transcriptions, data matrices, concept maps, journaling, and writing. Participants augmented active learning strategies with strategies that linked course topics to the subject of occupation. The use of linking strategies suggested that: (a) course content was treated as two-tiered; (b) neither content nor instructional processes were inherently occupation-centered; and (c) subject-centered education strengthens social learning theories. Although curricula may appear occupation-centered based on a curriculum description and course content, ultimately "linking opportunities" in the classroom constitute an essential feature that demarcates a program as occupation-centered.

  17. Activities report 1991-1992: Nuclear Research Center of Strasbourg

    International Nuclear Information System (INIS)

    This activities report of the Nuclear Research Centre of Strasbourg for the years 1991 and 1992, presents nine research axis: theoretical physics, mechanisms of reactions and nuclear structure, extreme forms of nuclei, exotic nuclei, hot and dense nuclear matter, ultra-relativistic heavy ions, physics of LEP (European Large Electron-Positron storage ring) at 'DELPHI', chemistry and physics of radiations, physics and applications of semi-conductors

  18. Joint research center activity in thermonuclear fusion technology

    Energy Technology Data Exchange (ETDEWEB)

    Casini, G.; Rocco, P. (Commission of the European Communities, Ispra (Italy). Joint Research Centre)

    1984-04-01

    A review of the activities in progress in the field of thermonuclear fusion technology at the Joint Research Centre of the European Communities is presented. The research areas are: (I) reactor studies, including conceptual design studies of experimental Tokamak reactors (INTOR/NET) and safety analyses; (II) experimental investigation on first wall and blanket materials and components. Emphasis has been given to those topics which are not reported in detail in the following articles of the issue.

  19. Organization of accounting for expenditures connected with the environmental protection activity based on responsibility centers

    OpenAIRE

    Корнєєва, Тетяна Іванівна

    2015-01-01

    Organization of accounting for expenditures connected with environmental protection activity based on responsibility centers at the enterprises of coal industry depending on the level of influence and managerial decision-making has been improved. The detailed description of expenditures connected with environmental protection activity depending on the places of their origin and cost centers in the context of sources of contaminants’ appearance, technological processes and levels of danger for...

  20. Segmentation of visitors to shopping centers based on their activities through factor analysis and cluster analysis

    Directory of Open Access Journals (Sweden)

    reza soleymani-damaneh

    2013-08-01

    Full Text Available Knowing customers of shopping centers contributes greatly to increase profits of these centers. Segmentation of the customers is one of the most effective means of knowing the customers. The purpose of this study was to present a segmentation of the customers based on their activities in the shopping centers. The participants were 157 visitors to Milad-e-Noor Shopping Center who were required to answer the questions in the questionnaire. Data were analyzed in three steps. Through the use of factor analysis, in the first step, the number of variables was reduced to the four factors of entertainment activities, planned shopping, shopping information gathering and unplanned shopping. These factors were then inserted into K-mean cluster analysis and, in the second step and the visitors were divided into 4 segments on the basis of their activity as following: traditionalists, shopping center enthusiasts, wandering customers, and entertainment seekers. In the third step, the demographic and behavioral variables were investigated in the identified clusters. Considering the variables of age, academic status and accompanying persons in shopping centers, these clusters were significantly different. In respect to variables of sex, marital status, the length of presence in the shopping centers, occupations and monthly salary they were recognized as homogenous, however.

  1. DEPENDENCE OF THE DISTRIBUTION OF ACTIVE CENTERS ON MONOMER IN SUPPORTED ZIEGLER-NATTA CATALYSTS

    Institute of Scientific and Technical Information of China (English)

    Le-tian Zhang; Zhi-qiang Fan; Zhi-sheng Fu

    2008-01-01

    Distribution of active centers(ACD)of ethylene or 1-hexene homopolymerization and ethylene-1-hexene copolymerization with a MgCl2/TiCl4 type Z-N catalyst were studied by deconvolution of the polymer molecular weight distribution into multiple Flory components.Each Flory component is thought to be formed by a certain type of active center.ACD of ethylene-1-hexene copolymer with very low 1-hexene incorporation was compared with that of ethylene homopolymer to see the effect of introducing a-olefin on ethylene polymerization.On the other hand.ACD of ethylene-1-hexene copolymer with very low ethylene incorporation was compared with that of 1-hexene homopolymer.Adding small amount of 1-hexene in ethylene polymerization caused marked activation of all the Flory components of the polymer.in which the low molecular weight components are activated more than the high molecular weight components.In 1-hexene polymerization system,the activity can also be greatly enhanced by introducing small amount of ethylene.but the different Flory components(or active centers) are activated with similar extent,except a newly emerged active center producing polymer with the lowest molecular weight.The total number of active centers is markedly increased by adding small amount of ethylene in 1-hexene polymerization,but the average catalysis efficiency of the active centers decreased.The broad composition distribution of the ethylene-1-hexene copolymer Can be well understood from the ACD of catalyst and is dependence on the monomer.

  2. Physical activity in child-care centers: do teachers hold the key to the playground?

    OpenAIRE

    COPELAND, KRISTEN A.; Kendeigh, Cassandra A; Saelens, Brian E; Kalkwarf, Heidi J.; Sherman, Susan N.

    2011-01-01

    Many (56%) US children aged 3–5 years are in center-based childcare and are not obtaining recommended levels of physical activity. In order to determine what child-care teachers/providers perceived as benefits and barriers to children’s physical activity in child-care centers, we conducted nine focus groups and 13 one-on-one interviews with 49 child-care teachers/providers in Cincinnati, OH. Participants noted physical and socio-emotional benefits of physical activity particular to preschoole...

  3. Quality-Assurance Plan for Water-Quality Activities in the USGS Ohio Water Science Center

    Science.gov (United States)

    Francy, Donna S.; Shaffer, Kimberly H.

    2008-01-01

    In accordance with guidelines set forth by the Office of Water Quality in the Water Resources Discipline of the U.S. Geological Survey, a quality-assurance plan has been written for use by the Ohio Water Science Center in conducting water-quality activities. This quality-assurance plan documents the standards, policies, and procedures used by the Ohio Water Science Center for activities related to the collection, processing, storage, analysis, and publication of water-quality data. The policies and procedures documented in this quality-assurance plan for water-quality activities are meant to complement the Ohio Water Science Center quality-assurance plans for water-quality monitors, the microbiology laboratory, and surface-water and ground-water activities.

  4. Carbon Dioxide Information Analysis Center and World Data Center-A for atmospheric trace gases: FY 1993 activities

    International Nuclear Information System (INIS)

    During the course of a fiscal year, Oak Ridge National Laboratory's Carbon Dioxide Information Analysis Center (CDIAC) distributes thousands of specialty publications-numeric data packages (NDPs), computer model packages (CMPs), technical reports, public communication publications, newsletters, article reprints, and reference books-in response to requests for information related to global environmental issues, primarily those pertaining to climate change. CDIAC's staff also provide technical responses to specific inquiries related to carbon dioxide (CO2), other trace gases, and climate. Hundreds of referrals to other researchers, policy analysts, information specialists, or organizations are also facilitated by CDIAC's staff. This report provides an account of the activities accomplished by CDIAC (including World Data Center-A for Atmospheric Trace Gases) during the period October 1, 1992, to September 30, 1993. An organizational overview of CDIAC and its staff is supplemented by a detailed description of inquiries received and CDIAC's response to those inquiries. An analysis and description of the preparation and distribution of NDPS, CMPS, technical reports, newsletters, fact sheets, specialty publications, and reprints are provided. Comments and descriptions of CDIAC's information management systems, professional networking, and special bilateral agreements are also presented

  5. Carbon Dioxide Information Analysis Center and World Data Center-A for atmospheric trace gases: FY 1993 activities

    Energy Technology Data Exchange (ETDEWEB)

    Cushman, R.M. [Oak Ridge National Lab., TN (United States). Carbon Dioxide Information Analysis Center; Stoss, F.W. [Oak Ridge National Lab., TN (United States). Carbon Dioxide Information Analysis Center]|[Univ. of Tennessee, Knoxville, TN (United States). Energy, Environment, and Resources Center

    1994-01-01

    During the course of a fiscal year, Oak Ridge National Laboratory`s Carbon Dioxide Information Analysis Center (CDIAC) distributes thousands of specialty publications-numeric data packages (NDPs), computer model packages (CMPs), technical reports, public communication publications, newsletters, article reprints, and reference books-in response to requests for information related to global environmental issues, primarily those pertaining to climate change. CDIAC`s staff also provide technical responses to specific inquiries related to carbon dioxide (CO{sub 2}), other trace gases, and climate. Hundreds of referrals to other researchers, policy analysts, information specialists, or organizations are also facilitated by CDIAC`s staff. This report provides an account of the activities accomplished by CDIAC (including World Data Center-A for Atmospheric Trace Gases) during the period October 1, 1992, to September 30, 1993. An organizational overview of CDIAC and its staff is supplemented by a detailed description of inquiries received and CDIAC`s response to those inquiries. An analysis and description of the preparation and distribution of NDPS, CMPS, technical reports, newsletters, fact sheets, specialty publications, and reprints are provided. Comments and descriptions of CDIAC`s information management systems, professional networking, and special bilateral agreements are also presented.

  6. Inhibition of Heme Peroxidase During Phenol Derivatives Oxidation. Possible Molecular Cloaking of the Active Center

    Directory of Open Access Journals (Sweden)

    Juozas Kulys

    2005-10-01

    Full Text Available Abstract: Ab initio quantum chemical calculations have been applied to the study of the molecular structure of phenol derivatives and oligomers produced during peroxidasecatalyzed oxidation. The interaction of substrates and oligomers with Arthromyces ramosus peroxidase was analyzed by docking methods. The most possible interaction site of oligomers is an active center of the peroxidase. The complexation energy increases with increasing oligomer length. However, the complexed oligomers do not form a precise (for the reaction hydrogen bonding network in the active center of the enzyme. It seems likely that strong but non productive docking of the oligomers determines peroxidase inhibition during the reaction.

  7. Can a Satellite Galaxy Merger Explain the Active Past of the Galactic Center?

    CERN Document Server

    Lang, Meagan; Bogdanovic, Tamara; Amaro-Seoane, Pau; Sesana, Alberto

    2011-01-01

    Observations of the Galactic Center (GC) have accumulated a multitude of "forensic" evidence indicating that several million years ago the center of the Milky Way galaxy was teaming with starforming and accretion-powered activity -- this paints a rather different picture from the GC as we understand it today. We examine a possibility that this epoch of activity could have been triggered by the infall of a satellite galaxy into the Milky Way which began at the redshift of 10 and ended few million years ago with a merger of the Galactic supermassive black hole with an intermediate mass black hole brought in by the inspiralling satellite.

  8. 34 CFR 656.3 - What activities define a comprehensive or undergraduate National Resource Center?

    Science.gov (United States)

    2010-07-01

    ... basis; (d) Maintains linkages with overseas institutions of higher education and other organizations... 34 Education 3 2010-07-01 2010-07-01 false What activities define a comprehensive or undergraduate National Resource Center? 656.3 Section 656.3 Education Regulations of the Offices of the Department...

  9. Nutrition and Physical Activity Practices in Childcare Centers versus Family Childcare Homes

    Science.gov (United States)

    Natale, Ruby; Page, Monica; Sanders, Lee

    2014-01-01

    Obesity rates among preschool-aged children have doubled in the past 10 years, and 60% of these children spend the majority of their day in childcare facilities. Few studies have examined the quality of nutrition and physical activity practices in childcare centers as compared to family childcare homes. The purpose of this study is to determine if…

  10. Centro Regional de Ciencias Nucleares (a Brazilian regional center for nuclear sciences) - activities report - 1999

    International Nuclear Information System (INIS)

    The annual activities report of 1999 of nuclear sciences regional center - Brazilian organization - introduces the next main topics: institutional relations; sectorial actions - logistic support and training, laboratory of radiation protection and dosimetry, laboratory of metrology, laboratory of chemical characterization; technical and scientific events; and financial resources and perspectives for 2000

  11. Goods and services from the activities of the Constituyentes Atomic Center

    International Nuclear Information System (INIS)

    Technologies developed and used at the Constituyentes Atomic Center (CAC) are applied in Argentina in different fields, such as seamless pipes industry, non-destructive testing and quality assurance, food industry, microalloyed steels, medicine, space activities, air pollution studies, etc. The CAC has also a wide program of technical assistance to the industry

  12. EFFECTS OF EXTERNAL DONOR ON ACTIVE CENTER DISTRIBUTION OF SUPPORTED ZIEGLER-NATTA CATALYST

    Institute of Scientific and Technical Information of China (English)

    FAN Zhiqiang; M. Carmela Sacchi; Paolo Locatelli

    1997-01-01

    The composition distribution (CD) and microisotacticity distribution (ID) of propene/1-hexene copolymer synthesized by MgCl2/DIBP/TiCl4 (DIBP: diisobutyl phthalate) were determined by fractionating the copolymers according to crystallinity and characterizing the fractions by 13C NMR. The effects of two alkoxysilane donors, triethoxyphenylsilane (PTES) and dimethoxydi-tert-butylsilane (TBMS), on CD and ID of the copolymers were compared. Three main parts in the CD diagram of each copolymer were distinguished,which were correlated to active center distribution (ACD) based on three groups of different active centers. By studying the changes in 1-hexene content, microisotacticity and reactivity ratio product of three typical fractions, the effects of external donor on ACD were better elucidated. It was found that TBMS shows much stronger effects on ACD than PTES. In the former system, most fractions were produced on active centers with relatively lower r1r2, higher reactivity to 1-hexene, and higher stereospecificity as compared to the system without external donor. It is concluded that the observed very extensive changes in ACD are mainly resulted by the formation of new types of active centers, possibly by coordination of external donor to certain positions on the catalyst.

  13. Active Learning and Student-centered Pedagogy Improve Student Attitudes and Performance in Introductory Biology

    OpenAIRE

    Armbruster, Peter; Patel, Maya; Johnson, Erika; Weiss, Martha

    2009-01-01

    We describe the development and implementation of an instructional design that focused on bringing multiple forms of active learning and student-centered pedagogies to a one-semester, undergraduate introductory biology course for both majors and nonmajors. Our course redesign consisted of three major elements: 1) reordering the presentation of the course content in an attempt to teach specific content within the context of broad conceptual themes, 2) incorporating active and problem-based lea...

  14. Center for Multiscale Plasma Dynamics: Report on Activities (UCLA/MIT), 2009-2010

    Energy Technology Data Exchange (ETDEWEB)

    Troy Carter

    2011-04-18

    The final 'phaseout' year of the CMPD ended July 2010; a no cost extension was requested until May 2011 in order to enable the MIT subcontract funds to be fully utilized. Research progress over this time included verification and validation activities for the BOUT and BOUT++ code, studies of spontaneous reconnection in the VTF facility at MIT, and studies of the interaction between Alfven waves and drift waves in LAPD. The CMPD also hosted the 6th plasma physics winter school in 2010 (jointly with the NSF frontier center the Center for Magnetic Self-Organization, significant funding came from NSF for this most recent iteration of the Winter School).

  15. Distinct mechanisms for DNA cleavage by myoglobin with a designed heme active center.

    Science.gov (United States)

    Zhao, Yuan; Du, Ke-Jie; Gao, Shu-Qin; He, Bo; Wen, Ge-Bo; Tan, Xiangshi; Lin, Ying-Wu

    2016-03-01

    Heme proteins perform diverse biological functions, of which myoglobin (Mb) is a representative protein. In this study, the O2 carrier Mb was shown to cleave double stranded DNA upon aerobic dithiothreitol-induced reduction, which is fine-tuned by an additional distal histidine, His29 or His43, engineered in the heme active center. Spectroscopic (UV-vis and EPR) and inhibition studies suggested that free radicals including singlet oxygen and hydroxyl radical are responsible for efficient DNA cleavage via an oxidative cleavage mechanism. On the other hand, L29E Mb, with a distinct heme active center involving three water molecules in the met form, was found to exhibit an excellent DNA cleavage activity that was not depending on O2. Inhibition and ligation studies demonstrated for the first time that L29E Mb cleaves double stranded DNA into both the nicked circular and linear forms via a hydrolytic cleavage mechanism, which resembles native endonucleases. This study provides valuable insights into the distinct mechanisms for DNA cleavage by heme proteins, and lays down a base for creating artificial DNA endonucleases by rational design of heme proteins. Moreover, this study suggests that the diverse functions of heme proteins can be fine-tuned by rational design of the heme active center with a hydrogen-bonding network.

  16. Assessment of food, nutrition, and physical activity practices in Oklahoma child-care centers.

    Science.gov (United States)

    Sisson, Susan B; Campbell, Janis E; May, Kellie B; Brittain, Danielle R; Monroe, Lisa A; Guss, Shannon H; Ladner, Jennifer L

    2012-08-01

    The purpose of the current study was to determine the obesogenic practices in all-day child-care centers caring for preschool-aged children. This study used a cross-sectional, self-reported survey mailed to centers across Oklahoma (n=314). Frequency of responses and χ(2) were calculated comparing region and star rating. Items where the majority of centers frequently report best practices include: daily fruits served (76%), daily nonfried vegetables served (71%), rarely/never served sugary drinks (92%), rarely/never used food to encourage good behaviors (88%), staff join children at table most of the time (81%), staff rarely eat different foods in view of children (69%), visible self-serve or request availability of water (93%), regular informal communication about healthy eating (86%), opportunities for outdoor play (95%), not withholding activity for punishment (91%), accessible play equipment (59% to 80% for different types of equipment), and minimization of extended sitting time (78%). Practices where centers can improve include increasing variety of vegetables (18%), reducing frequency of high-fat meats served (74% serve more than once per week), increasing high-fiber and whole-grain foods (35% offer daily), serving style of "seconds" (28% help kids determine whether they are still hungry), nonfood holiday celebrations (44% use nonfood treats), having toys and books that encourage healthy eating (27%) and physical activity (25%) in all rooms in the center, a standard nutrition (21%) and physical education (50%) curriculum, and following a written physical activity policy (43%). Practitioners can use these data to develop benchmarks and interventions, as this was the first study to assess statewide obesogenic practices in child care.

  17. Societal Values and Policies May Curtail Preschool Children’s Physical Activity in Child Care Centers

    Science.gov (United States)

    Sherman, Susan N.; Kendeigh, Cassandra A.; Kalkwarf, Heidi J.; Saelens, Brian E.

    2012-01-01

    BACKGROUND AND OBJECTIVES: Three-fourths of US preschool-age children are in child care centers. Children are primarily sedentary in these settings, and are not meeting recommended levels of physical activity. Our objective was to identify potential barriers to children’s physical activity in child care centers. METHODS: Nine focus groups with 49 child care providers (55% African American) were assembled from 34 centers (inner-city, suburban, Head Start, and Montessori) in Cincinnati, Ohio. Three coders independently analyzed verbatim transcripts for themes. Data analysis and interpretation of findings were verified through triangulation of methods. RESULTS: We identified 3 main barriers to children’s physical activity in child care: (1) injury concerns, (2) financial, and (3) a focus on “academics.” Stricter licensing codes intended to reduce children's injuries on playgrounds rendered playgrounds less physically challenging and interesting. In addition, some parents concerned about potential injury, requested staff to restrict playground participation for their children. Small operating margins of most child care centers limited their ability to install abundant playground equipment. Child care providers felt pressure from state mandates and parents to focus on academics at the expense of gross motor play. Because children spend long hours in care and many lack a safe place to play near their home, these barriers may limit children's only opportunity to engage in physical activity. CONCLUSIONS: Societal priorities for young children—safety and school readiness—may be hindering children’s physical development. In designing environments that optimally promote children’s health and development, child advocates should think holistically about potential unintended consequences of policies. PMID:22218842

  18. Strategic Planning for Activation and Operation of the North Central Superpave Center (NCSC): Interim Report

    OpenAIRE

    Olek, J.; McDaniel, Rebecca

    1997-01-01

    The North Central Superpave Center (NCSC) was established to serve the needs of the states and industry in ten states and two Canadian provinces as they implement the Superpave system. Accomplishing this goal requires the cooperation and active support of a number of people and organizations. Organizational and operational issues related to infrastructure, personnel, equipment and finances also needed to be resolved. This project was designed to address those issues, develop a comprehensive s...

  19. Person-Centered, Physical Activity for Patients with Low Back Pain: Piloting Service Delivery

    Directory of Open Access Journals (Sweden)

    Saul Bloxham

    2016-05-01

    Full Text Available Low back pain (LBP is one of the most common and costly conditions in industrialized countries. Exercise therapy has been used to treat LBP, although typically using only one mode of exercise. This paper describes the method and initial findings of a person-centered, group physical activity programme which featured as part of a multidisciplinary approach to treating LBP. Six participants (aged 50.7 ± 17 years completed a six-week physical activity programme lasting two hours per week. A multicomponent approach to physical activity was adopted which included aerobic fitness, core activation, muscular strength and endurance, Nordic Walking, flexibility and exercise gaming. In addition, participants were required to use diary sheets to record physical activity completed at home. Results revealed significant (p < 0.05 improvements in back strength (23%, aerobic fitness (23%, negative wellbeing (32% and disability (16%. Person’s Correlation Coefficient analysis revealed significant (p < 0.05 relationships between improvement in perceived pain and aerobic fitness (r = 0.93. It was concluded that a person-centered, multicomponent approach to physical activity may be optimal for supporting patients who self-manage LBP.

  20. Communication between Thiamin Cofactors in the Escherichia coli Pyruvate Dehydrogenase Complex E1 Component Active Centers

    Science.gov (United States)

    Nemeria, Natalia S.; Arjunan, Palaniappa; Chandrasekhar, Krishnamoorthy; Mossad, Madouna; Tittmann, Kai; Furey, William; Jordan, Frank

    2010-01-01

    Kinetic, spectroscopic, and structural analysis tested the hypothesis that a chain of residues connecting the 4′-aminopyrimidine N1′ atoms of thiamin diphosphates (ThDPs) in the two active centers of the Escherichia coli pyruvate dehydrogenase complex E1 component provides a signal transduction pathway. Substitution of the three acidic residues (Glu571, Glu235, and Glu237) and Arg606 resulted in impaired binding of the second ThDP, once the first active center was filled, suggesting a pathway for communication between the two ThDPs. 1) Steady-state kinetic and fluorescence quenching studies revealed that upon E571A, E235A, E237A, and R606A substitutions, ThDP binding in the second active center was affected. 2) Analysis of the kinetics of thiazolium C2 hydrogen/deuterium exchange of enzyme-bound ThDP suggests half-of-the-sites reactivity for the E1 component, with fast (activated site) and slow exchanging sites (dormant site). The E235A and E571A variants gave no evidence for the slow exchanging site, indicating that only one of two active sites is filled with ThDP. 3) Titration of the E235A and E237A variants with methyl acetylphosphonate monitored by circular dichroism suggested that only half of the active sites were filled with a covalent predecarboxylation intermediate analog. 4) Crystal structures of E235A and E571A in complex with ThDP revealed the structural basis for the spectroscopic and kinetic observations and showed that either substitution affects cofactor binding, despite the fact that Glu235 makes no direct contact with the cofactor. The role of the conserved Glu571 residue in both catalysis and cofactor orientation is revealed by the combined results for the first time. PMID:20106967

  1. The 1988 activity report of the Nuclear Research Center of Strasbourg

    International Nuclear Information System (INIS)

    The 1988 activity report of Nuclear Research Center of Strasbourg (France) is presented. 1988 is characterized by significant technical development activities in the field of heavy ion collisions. Several aspects involving the Vivitron system development and objectives are underlined. The main research fields are those on high angular momentum and superplasticity, layer model and nucleon transfer, nuclei far from steady state, scattering model and fusion cross sections. The research programs of the Nuclear Physics, High Energies, Chemistry and Radiation Physics Divisions are presented. Concerning technology transfer, the investigations on accelerators and dosimetry are included. International cooperation main aspects, papers, congress communications and conferences are reported

  2. Reasearch Activities for the Establishment of The Center for Sustainable Energy

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Michael Seliger

    2005-08-08

    In 2003, Bronx Community College received a grant of $481,000 through the United States Department of Energy for the purpose of conducting research- related activities leading to the creation of the Center for Sustainable Energy at Bronx Community College. The award, which was administered on behalf of Bronx Community College by the Research Foundation of the City University of New York, was initially for one year, from October 2003 through September 30, 2004. It received a no-cost extension to June 30, 2005. This report presents a summary of the activities and accomplishments attributable to the award.

  3. The Solar Thermal Design Assistance Center report of its activities and accomplishments in Fiscal Year 1993

    Energy Technology Data Exchange (ETDEWEB)

    Menicucci, D.F.

    1994-03-01

    The Solar Thermal Design Assistance Center (STDAC) at Sandia National Laboratories is a resource provided by the US Department of Energy`s Solar Thermal Program. Its major objectives are to accelerate the use of solar thermal systems through (a) direct technical assistance to users, (b) cooperative test, evaluation, and development efforts with private industry, and (c) educational outreach activities. This report outlines the major activities and accomplishments of the STDAC in Fiscal Year 1993. The report also contains a comprehensive list of persons who contacted the STDAC by telephone for information or technical consulting.

  4. Quality-assurance plan for groundwater activities, U.S. Geological Survey, Washington Water Science Center

    Science.gov (United States)

    Kozar, Mark D.; Kahle, Sue C.

    2013-01-01

    This report documents the standard procedures, policies, and field methods used by the U.S. Geological Survey’s (USGS) Washington Water Science Center staff for activities related to the collection, processing, analysis, storage, and publication of groundwater data. This groundwater quality-assurance plan changes through time to accommodate new methods and requirements developed by the Washington Water Science Center and the USGS Office of Groundwater. The plan is based largely on requirements and guidelines provided by the USGS Office of Groundwater, or the USGS Water Mission Area. Regular updates to this plan represent an integral part of the quality-assurance process. Because numerous policy memoranda have been issued by the Office of Groundwater since the previous groundwater quality assurance plan was written, this report is a substantial revision of the previous report, supplants it, and contains significant additional policies not covered in the previous report. This updated plan includes information related to the organization and responsibilities of USGS Washington Water Science Center staff, training, safety, project proposal development, project review procedures, data collection activities, data processing activities, report review procedures, and archiving of field data and interpretative information pertaining to groundwater flow models, borehole aquifer tests, and aquifer tests. Important updates from the previous groundwater quality assurance plan include: (1) procedures for documenting and archiving of groundwater flow models; (2) revisions to procedures and policies for the creation of sites in the Groundwater Site Inventory database; (3) adoption of new water-level forms to be used within the USGS Washington Water Science Center; (4) procedures for future creation of borehole geophysics, surface geophysics, and aquifer-test archives; and (5) use of the USGS Multi Optional Network Key Entry System software for entry of routine water-level data

  5. The ORNL Controlled Fusion Atomic Data Center: Overview of Activities 2011

    International Nuclear Information System (INIS)

    The Controlled Fusion Atomic Data Center (CFADC) of the Oak Ridge National Laboratory continued operation aimed at collecting, evaluating, and disseminating atomic, molecular, and particle-surface interaction (AM and PSI) data needed by both the U.S. and international plasma science communities. This work has been carried out within an overarching atomic physics research group which produces much of the required data through an active experimental and theoretical science program. The production of an annotated bibliography of AM and PSI literature relevant to plasma science continues to be among the most important activities of the data center, forming the basis for the CFADC on-line bibliographic search engine and a significant part of the IAEA A+M Data Unit's 'International Bulletin on Atomic and Molecular Data for Fusion.' Also chief among the data center's activities are responses to specific data requests from the plasma science community, leading to either rapid feedback using existing data resources or long term data production projects, as well as participation in IAEA Coordinated Research Programs including recently 'Data for Surface Composition Dynamics Relevant to Erosion Processes' and 'Atomic and Molecular Data for Plasma Modeling.' Highlights of recent data production projects include the following: Experimental and theoretical data for inelastic electron-hydrocarbon reactions, large scale computational results for particle reflection from surfaces, measurements of chemical sputtering from carbon, inaugural experiments considering molecular ion collisions with neutral hydrogen, and expansion of the database of elastic and related transport cross sections calculated for intrinsic and extrinsic impurities in hydrogen plasmas. Progress is being hampered owing to news from the US Department of Energy that it plans to close out the program after a ramp down of funding in 2012, following a distinguished 52 year history of contributions to the US and

  6. STUDY ON THE MECHANISM OF 1-OCTENE ZIEGLER-NATTA POLYMERIZATION BASED ON THE NUMBER OF ACTIVE CENTERS

    Institute of Scientific and Technical Information of China (English)

    FAN Zhiqiang; FENG Linxian; YANG Shilin

    1991-01-01

    The number of active centers (Cp )-t and kp-t profiles of Solvay type TiCl3 - AlR3 (R= C2H5, i - C4H9 )or Stauffer AA TiCl3-Al (C2H5)3 catalyzed 1-octene polymerization were determined by using an acetyl chloride quenching method as well as kinetic data. The results show that in the studied systems kp decreases when Cp increases, indicating the presence of two or more types of different active centers. The Cp-t plots of the Solvay TiCl3- AlR3 systems show the presence of both stable active centers and unstable centers which decay in the polymerization process. The phenomena are explained based on a model of active center plurality. The increases of Cp in the induction periods are also discussed.

  7. Water-containing hydrogen-bonding network in the active center of channelrhodopsin.

    Science.gov (United States)

    Ito, Shota; Kato, Hideaki E; Taniguchi, Reiya; Iwata, Tatsuya; Nureki, Osamu; Kandori, Hideki

    2014-03-01

    Channelrhodopsin (ChR) functions as a light-gated ion channel in Chlamydomonas reinhardtii. Passive transport of cations by ChR is fundamentally different from the active transport by light-driven ion pumps such as archaerhodopsin, bacteriorhodopsin, and halorhodopsin. These microbial rhodopsins are important tools for optogenetics, where ChR is used to activate neurons by light, while the ion pumps are used for neural silencing. Ion-transport functions by these rhodopsins strongly depend on the specific hydrogen-bonding networks containing water near the retinal chromophore. In this work, we measured protein-bound water molecules in a chimeric ChR protein of ChR1 (helices A to E) and ChR2 (helices F and G) of Chlamydomonas reinhardtii using low-temperature FTIR spectroscopy at 77 K. We found that the active center of ChR possesses more water molecules (9 water vibrations) than those of other microbial (2-6 water vibrations) and animal (6-8 water vibrations) rhodopsins. We conclude that the protonated retinal Schiff base interacts with the counterion (Glu162) directly, without the intervening water molecule found in proton-pumping microbial rhodopsins. The present FTIR results and the recent X-ray structure of ChR reveal a unique hydrogen-bonding network around the active center of this light-gated ion channel. PMID:24512107

  8. Evaluation design of New York City's regulations on nutrition, physical activity, and screen time in early child care centers.

    Science.gov (United States)

    Breck, Andrew; Goodman, Ken; Dunn, Lillian; Stephens, Robert L; Dawkins, Nicola; Dixon, Beth; Jernigan, Jan; Kakietek, Jakub; Lesesne, Catherine; Lessard, Laura; Nonas, Cathy; O'Dell, Sarah Abood; Osuji, Thearis A; Bronson, Bernice; Xu, Ye; Kettel Khan, Laura

    2014-01-01

    This article describes the multi-method cross-sectional design used to evaluate New York City Department of Health and Mental Hygiene's regulations of nutrition, physical activity, and screen time for children aged 3 years or older in licensed group child care centers. The Center Evaluation Component collected data from a stratified random sample of 176 licensed group child care centers in New York City. Compliance with the regulations was measured through a review of center records, a facility inventory, and interviews of center directors, lead teachers, and food service staff. The Classroom Evaluation Component included an observational and biometric study of a sample of approximately 1,400 children aged 3 or 4 years attending 110 child care centers and was designed to complement the center component at the classroom and child level. The study methodology detailed in this paper may aid researchers in designing policy evaluation studies that can inform other jurisdictions considering similar policies. PMID:25321635

  9. Activation and implementation of a Federal Radiological Monitoring and Assessment Center

    International Nuclear Information System (INIS)

    The Nevada Operations Office of the U.S. Department of Energy (DOE/NV) has been assigned the primary responsibility for responding to a major radiological emergency. The initial response to any radiological emergency, however, will probably be conducted under the DOE regional radiological assistance plan (RAP). If the dimensions of the crisis demand federal assistance, the following sequence of events may be anticipated: (1) DOE regional RAP response, (2) activation of the Federal Radiological Monitoring and Assistance Center (FRMAC) requested, (3) aerial measuring systems and DOE/NV advance party respond, (4) FRMAC activated, (5) FRMAC responds to state(s) and cognizant federal agency (CFA), and (6) management of FRMAC transferred to the Environmental Protection Agency (EPA). The paper discusses activation channels, authorization, notification, deployment, and interfaces

  10. Clinical process analysis and activity-based costing at a heart center.

    Science.gov (United States)

    Ridderstolpe, Lisa; Johansson, Andreas; Skau, Tommy; Rutberg, Hans; Ahlfeldt, Hans

    2002-08-01

    Cost studies, productivity, efficiency, and quality of care measures, the links between resources and patient outcomes, are fundamental issues for hospital management today. This paper describes the implementation of a model for process analysis and activity-based costing (ABC)/management at a Heart Center in Sweden as a tool for administrative cost information, strategic decision-making, quality improvement, and cost reduction. A commercial software package (QPR) containing two interrelated parts, "ProcessGuide and CostControl," was used. All processes at the Heart Center were mapped and graphically outlined. Processes and activities such as health care procedures, research, and education were identified together with their causal relationship to costs and products/services. The construction of the ABC model in CostControl was time-consuming. However, after the ABC/management system was created, it opened the way for new possibilities including process and activity analysis, simulation, and price calculations. Cost analysis showed large variations in the cost obtained for individual patients undergoing coronary artery bypass grafting (CABG) surgery. We conclude that a process-based costing system is applicable and has the potential to be useful in hospital management. PMID:12118815

  11. Clinical process analysis and activity-based costing at a heart center.

    Science.gov (United States)

    Ridderstolpe, Lisa; Johansson, Andreas; Skau, Tommy; Rutberg, Hans; Ahlfeldt, Hans

    2002-08-01

    Cost studies, productivity, efficiency, and quality of care measures, the links between resources and patient outcomes, are fundamental issues for hospital management today. This paper describes the implementation of a model for process analysis and activity-based costing (ABC)/management at a Heart Center in Sweden as a tool for administrative cost information, strategic decision-making, quality improvement, and cost reduction. A commercial software package (QPR) containing two interrelated parts, "ProcessGuide and CostControl," was used. All processes at the Heart Center were mapped and graphically outlined. Processes and activities such as health care procedures, research, and education were identified together with their causal relationship to costs and products/services. The construction of the ABC model in CostControl was time-consuming. However, after the ABC/management system was created, it opened the way for new possibilities including process and activity analysis, simulation, and price calculations. Cost analysis showed large variations in the cost obtained for individual patients undergoing coronary artery bypass grafting (CABG) surgery. We conclude that a process-based costing system is applicable and has the potential to be useful in hospital management.

  12. Human Collagen Prolyl 4-Hydroxylase Is Activated by Ligands for Its Iron Center.

    Science.gov (United States)

    Vasta, James D; Raines, Ronald T

    2016-06-14

    Collagen is the most abundant protein in animals. The posttranslational hydroxylation of proline residues in collagen contributes greatly to its conformational stability. Deficient hydroxylation is associated with a variety of disease states, including scurvy. The hydroxylation of proline residues in collagen is catalyzed by an Fe(II)- and α-ketoglutarate-dependent dioxygenase, collagen prolyl 4-hydroxylase (CP4H). CP4H has long been known to suffer oxidative inactivation during catalysis, and the cofactor ascorbate (vitamin C) is required to reactivate the enzyme by reducing its iron center from Fe(III) to Fe(II). Herein, we report on the discovery of the first synthetic activators of CP4H. Specifically, we find that 2,2'-bipyridine-4-carboxylate and 2,2'-bipyridine-5-carboxylate serve as ligands for the iron center in human CP4H that enhance the rate of ascorbate-dependent reactivation. This new mode of CP4H activation is available to other biheteroaryl compounds but does not necessarily extend to other prolyl 4-hydroxylases. As collagen is weakened in many indications, analogous activators of CP4H could have therapeutic benefits. PMID:27183028

  13. JPL Physical Oceanography Distributed Active Archive Center (PO.DAAC) data availability, version 1-94

    Science.gov (United States)

    1994-01-01

    The Physical Oceanography Distributed Active Archive Center (PO.DAAC) archive at the Jet Propulsion Laboratory (JPL) includes satellite data sets for the ocean sciences and global-change research to facilitate multidisciplinary use of satellite ocean data. Parameters include sea-surface height, surface-wind vector, sea-surface temperature, atmospheric liquid water, and integrated water vapor. The JPL PO.DAAC is an element of the Earth Observing System Data and Information System (EOSDIS) and is the United States distribution site for Ocean Topography Experiment (TOPEX)/POSEIDON data and metadata.

  14. Galactic Center gamma-ray ``excess'' from an active past of the Galactic Centre?

    Science.gov (United States)

    Petrović, Jovana; Dario Serpico, Pasquale; Zaharijaš, Gabrijela

    2014-10-01

    Several groups have recently claimed evidence for an unaccounted gamma-ray excess over the diffuse backgrounds at few GeV in the Fermi-LAT data in a region around the Galactic Center, consistent with a dark matter annihilation origin. We demonstrate that the main spectral and angular features of this excess can be reproduced if they are mostly due to inverse Compton emission from high-energy electrons injected in a burst event of ~ 1052÷1053 erg roughly Script O(106) years ago. We consider this example as a proof of principle that time-dependent phenomena need to be understood and accounted for—together with detailed diffuse foregrounds and unaccounted ``steady state'' astrophysical sources—before any robust inference can be made about dark matter signals at the Galactic Center. In addition, we point out that the timescale suggested by our study, which controls both the energy cutoff and the angular extension of the signal, intriguingly matches (together with the energy budget) what is indirectly inferred by other evidences suggesting a very active Galactic Center in the past, for instance related to intense star formation and accretion phenomena.

  15. Discovery of the recombining plasma in the south of the Galactic center; a relic of the past Galactic center activity?

    CERN Document Server

    Nakashima, S; Uchida, H; Tanaka, T; Tsuru, T G; Koyama, K; Murakami, H; Uchiyama, H

    2013-01-01

    We report Suzaku results for soft X-ray emission to the south of the Galactic center (GC). The emission (hereafter "GC South") has an angular size of ~42' x 16' centered at (l, b) ~ (0.0, -1.4), and is located in the largely extended Galactic ridge X-ray emission (GRXE). The X-ray spectrum of GC South exhibits emission lines from highly ionized atoms. Although the X-ray spectrum of the GRXE can be well fitted with a plasma in collisional ionization equilibrium (CIE), that of GC South cannot be fitted with a plasma in CIE, leaving hump-like residuals at ~2.5 and 3.5 keV, which are attributable to the radiative recombination continua of the K-shells of Si and S, respectively. In fact, GC South spectrum is well fitted with a recombination-dominant plasma model; the electron temperature is 0.46 keV while atoms are highly ionized (kT = 1.6 keV) in the initial epoch, and the plasma is now in a recombining phase at a relaxation scale (plasma density x elapsed time) of 5.3 x 10^11 s cm^-3. The absorption column densi...

  16. Grounding Activity in People-Centered Smart Territories by Enhancing Community Awareness

    Directory of Open Access Journals (Sweden)

    John M. Carroll

    2014-05-01

    Full Text Available Contemporary life can seem rushed and overloaded. We argue this may be due not to merely having too much to do, but rather with experiencing fragmentation and inadequate meaning in one’s own activity. We suggest that a design approach to this challenge is to enhance awareness of significant and persistent activity, and the themes, values, places, and motivations that unifies it and gives it greater meaning. Specifically, we suggest that people-centered smart territories can enhance community awareness by reminding people of placed-based history, heritage, current issues and discussions, and plans for the future in the community through a smart social grid of community information services.

  17. Activity-based costing via an information system: an application created for a breast imaging center.

    Science.gov (United States)

    Hawkins, H; Langer, J; Padua, E; Reaves, J

    2001-06-01

    Activity-based costing (ABC) is a process that enables the estimation of the cost of producing a product or service. More accurate than traditional charge-based approaches, it emphasizes analysis of processes, and more specific identification of both direct and indirect costs. This accuracy is essential in today's healthcare environment, in which managed care organizations necessitate responsible and accountable costing. However, to be successfully utilized, it requires time, effort, expertise, and support. Data collection can be tedious and expensive. By integrating ABC with information management (IM) and systems (IS), organizations can take advantage of the process orientation of both, extend and improve ABC, and decrease resource utilization for ABC projects. In our case study, we have examined the process of a multidisciplinary breast center. We have mapped the constituent activities and established cost drivers. This information has been structured and included in our information system database for subsequent analysis.

  18. Activity-based costing via an information system: an application created for a breast imaging center.

    Science.gov (United States)

    Hawkins, H; Langer, J; Padua, E; Reaves, J

    2001-06-01

    Activity-based costing (ABC) is a process that enables the estimation of the cost of producing a product or service. More accurate than traditional charge-based approaches, it emphasizes analysis of processes, and more specific identification of both direct and indirect costs. This accuracy is essential in today's healthcare environment, in which managed care organizations necessitate responsible and accountable costing. However, to be successfully utilized, it requires time, effort, expertise, and support. Data collection can be tedious and expensive. By integrating ABC with information management (IM) and systems (IS), organizations can take advantage of the process orientation of both, extend and improve ABC, and decrease resource utilization for ABC projects. In our case study, we have examined the process of a multidisciplinary breast center. We have mapped the constituent activities and established cost drivers. This information has been structured and included in our information system database for subsequent analysis. PMID:11442093

  19. Passivation of electrically active centers by Hydrogen and Lithium in Semiconductors

    CERN Multimedia

    2002-01-01

    The hyperfine technique of Perturbed Angular Correlation Spectroscopy (PAC) has proven to be excellently suited for the microscopic investigation of impurity complexes in semiconductors. But this method is seriously limited by the small number of chemically different isotopes which are suitable for PAC measurements and represent electrically active centers in semiconductors. This bottleneck can be widely overcome by the ISOLDE facility which provides a great variety of shortliving PAC isotopes. The probe atom $^{111m}$Cd, provided by ISOLDE opened the first successful access to PAC investigations of III-V compounds and enabled also the first PAC experiments on double acceptors in silicon and germamum. \\\\ \\\\ At the new ISOLDE facility our experiments were concentrated on the passivation of electrically active centres by hydrogen and lithium in Si, Ge and III-V compounds. Experiments on $^{111m}$Cd in Ge revealed the formation of two different acceptor hydrogen and two different acceptor lithium complexes respe...

  20. Active learning and student-centered pedagogy improve student attitudes and performance in introductory biology.

    Science.gov (United States)

    Armbruster, Peter; Patel, Maya; Johnson, Erika; Weiss, Martha

    2009-01-01

    We describe the development and implementation of an instructional design that focused on bringing multiple forms of active learning and student-centered pedagogies to a one-semester, undergraduate introductory biology course for both majors and nonmajors. Our course redesign consisted of three major elements: 1) reordering the presentation of the course content in an attempt to teach specific content within the context of broad conceptual themes, 2) incorporating active and problem-based learning into every lecture, and 3) adopting strategies to create a more student-centered learning environment. Assessment of our instructional design consisted of a student survey and comparison of final exam performance across 3 years-1 year before our course redesign was implemented (2006) and during two successive years of implementation (2007 and 2008). The course restructuring led to significant improvement of self-reported student engagement and satisfaction and increased academic performance. We discuss the successes and ongoing challenges of our course restructuring and consider issues relevant to institutional change. PMID:19723815

  1. The main activities and scientific collaboration possibilities at Ankara Nuclear research and training center

    International Nuclear Information System (INIS)

    Full text: Founded in 1964, Ankara Nuclear Research and Training Center (ANRTC) conducts and facilitates the scientific activities including training (summer practice, MSc and Ph D studies in physics and chemistry, IAEA fellowship programs etc.), research and other studies in nuclear and related fields. As it's a part of main duties, ANRTC has analysis on the variety of samples, and radiation protection services commercially, for radiation workers in state, public and private sectors. Research, development and application projects implemented in this Center have mostly been supported by State Planning Organization (SPO) and Turkish Atomic Energy Authority (TAEA). In addition to the projects there are on going collaborative studies with some national Universities and International Atomic Energy Agency. The main activities carried out in ANRTC can be summarized as: studies on experimental nuclear physics, application of nuclear techniques such as XRF, XRD, Gamma, Alpha, etc. for environmental pollutants, archaeological and geological dating, elemental and crystal structural analyses, studies on the detection of irradiated foodstuff by ESR, development of accident dosimeters to be used in the case of a nuclear or radiological accident, and radiation matter interaction studies. In near future, for young scientists, there will be new collaboration possibilities related to accelerator-based applications, especially the new production methods of radioisotopes and their radiopharmaceuticals by using a cyclotron when our 30 MeVp / 15MeVd cyclotron facility project is underway

  2. Annual activities report of Brazilian Aerospace Technical Center -CTA/IEAv - 1989; Relatorio anual de atividades - CTA/IEAv - 1989

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1989-12-31

    This document reports the research activities on nuclear physics and reactors physics and engineering in the Brazilian Aerospace Technical Center/Advanced Studies Institute, Sao Paulo State, in the year of 1989.

  3. Ford/BASF/UM Activities in Support of the Hydrogen Storage Engineering Center of Excellence

    Energy Technology Data Exchange (ETDEWEB)

    Veenstra, Mike [Ford Scientific Research Lab., Dearborn, MI (United States); Purewal, Justin [Ford Scientific Research Lab., Dearborn, MI (United States); Xu, Chunchuan [Ford Scientific Research Lab., Dearborn, MI (United States); Yang, Jun [Ford Scientific Research Lab., Dearborn, MI (United States); Blaser, Rachel [Ford Scientific Research Lab., Dearborn, MI (United States); Sudik, Andrea [Ford Motor Company; Siegel, Don [University of Michigan; Ming, Yang [University of Michigan; Liu, Dong' an [University of Michigan; Chi, Hang [University of Michigan; Gaab, Manuela [BASF; Arnold, Lena [BASF; Muller, Ulrich [BASF

    2016-08-17

    revealed cost gaps and opportunities that identified a storage system that was lower cost than a 700 bar compressed system. Finally, we led the HSECoE efforts devoted to characterizing and enhancing metal organic framework (MOF) storage materials. This report serves as a final documentation of the Ford-UM-BASF project contributions to the HSECoE during the 6-year timeframe of the Center. The activities of the HSECoE have impacted the broader goals of the DOE-EERE and USDRIVE, leading to improved understanding in the engineering of materials-based hydrogen storage systems. This knowledge is a prerequisite to the development of a commercially-viable hydrogen storage system.

  4. Ford/BASF/UM Activities in Support of the Hydrogen Storage Engineering Center of Excellence

    Energy Technology Data Exchange (ETDEWEB)

    Veenstra, Mike [Ford Motor Company, Dearborn, MI (United States); Purewal, Justin [Ford Motor Company, Dearborn, MI (United States); Xu, Chunchuan [Ford Motor Company, Dearborn, MI (United States); Yang, Jun [Ford Motor Company, Dearborn, MI (United States); Blaser, Rachel [Ford Motor Company, Dearborn, MI (United States); Sudik, Andrea [Ford Motor Company, Dearborn, MI (United States); Siegel, Don [Univ. of Michigan, Ann Arbor, MI (United States); Ming, Yang [Univ. of Michigan, Ann Arbor, MI (United States); Liu, Dong' an [Univ. of Michigan, Ann Arbor, MI (United States); Chi, Hang [Univ. of Michigan, Ann Arbor, MI (United States); Gaab, Manuela [BASF SE, Ludwigshafen (Germany); Arnold, Lena [BASF SE, Ludwigshafen (Germany); Muller, Ulrich [BASF SE, Ludwigshafen (Germany)

    2015-06-30

    revealed cost gaps and opportunities that identified a storage system that was lower cost than a 700 bar compressed system. Finally, we led the HSECoE efforts devoted to characterizing and enhancing metal organic framework (MOF) storage materials. This report serves as a final documentation of the Ford-UM-BASF project contributions to the HSECoE during the 6-year timeframe of the Center. The activities of the HSECoE have impacted the broader goals of the DOE-EERE and USDRIVE, leading to improved understanding in the engineering of materials-based hydrogen storage systems. This knowledge is a prerequisite to the development of a commercially-viable hydrogen storage system.

  5. Home-Type Activities at the Day Care Center. (Tipos De Actividades Del Hogar En El Centro De Cuidado Diario.)

    Science.gov (United States)

    Aaronson, May; Moberg, Patricia E.

    This paper argues that home activities comprise a valuable unplanned curriculum and that many of these activities can be transferred to the day care center. It is suggested that these activities foster a closer relationship between child and caregiver and bridge the gap between familiar home environment and novel day care setting. Home activities…

  6. Introducing a 2-His-1-Glu Nonheme Iron Center into Myoglobin Confers Nitric Oxide Reductase Activity

    Energy Technology Data Exchange (ETDEWEB)

    Y Lin; N Yeung; Y Gao; K Miner; L Lei; H Robinson; Y Lu

    2011-12-31

    A conserved 2-His-1-Glu metal center, as found in natural nonheme iron-containing enzymes, was engineered into sperm whale myoglobin by replacing Leu29 and Phe43 with Glu and His, respectively (swMb L29E, F43H, H64, called Fe{sub B}Mb(-His)). A high resolution (1.65 {angstrom}) crystal structure of Cu(II)-CN{sup -}-Fe{sub B}Mb(-His) was determined, demonstrating that the unique 2-His-1-Glu metal center was successfully created within swMb. The Fe{sub B}Mb(-His) can bind Cu, Fe, or Zn ions, with both Cu(I)-Fe{sub B}Mb(-His) and Fe(II)-Fe{sub B}Mb(-His) exhibiting nitric oxide reductase (NOR) activities. Cu dependent NOR activity was significantly higher than that of Fe in the same metal binding site. EPR studies showed that the reduction of NO to N{sub 2}O catalyzed by these two enzymes resulted in different intermediates; a five-coordinate heme-NO species was observed for Cu(I)-Fe{sub B}Mb(-His) due to the cleavage of the proximal heme Fe-His bond, while Fe(II)-Fe{sub B}Mb(-His) remained six-coordinate. Therefore, both the metal ligand, Glu29, and the metal itself, Cu or Fe, play crucial roles in NOR activity. This study presents a novel protein model of NOR and provides insights into a newly discovered member of the NOR family, gNOR.

  7. Introducing a 2-His-1-Glu Nonheme Iron Center into Myoglobin Confers Nitric Oxide Reductase Activity

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Y.W.; Robinson, H.; Yeung, N.; Gao, Y.-G.; Miner, K. D.; Lei, L.; Lu, Y.

    2010-07-28

    A conserved 2-His-1-Glu metal center, as found in natural nonheme iron-containing enzymes, was engineered into sperm whale myoglobin by replacing Leu29 and Phe43 with Glu and His, respectively (swMb L29E, F43H, H64, called Fe{sub B}Mb(-His)). A high resolution (1.65 {angstrom}) crystal structure of Cu(II)-CN?-Fe{sub B}Mb(-His) was determined, demonstrating that the unique 2-His-1-Glu metal center was successfully created within swMb. The Fe{sub B}Mb(-His) can bind Cu, Fe, or Zn ions, with both Cu(I)-Fe{sub B}Mb(-His) and Fe(II)-Fe{sub B}Mb(-His) exhibiting nitric oxide reductase (NOR) activities. Cu dependent NOR activity was significantly higher than that of Fe in the same metal binding site. EPR studies showed that the reduction of NO to N{sub 2}O catalyzed by these two enzymes resulted in different intermediates; a five-coordinate heme-NO species was observed for Cu(I)-Fe{sub B}Mb(-His) due to the cleavage of the proximal heme Fe-His bond, while Fe(II)-Fe{sub B}Mb(-His) remained six-coordinate. Therefore, both the metal ligand, Glu29, and the metal itself, Cu or Fe, play crucial roles in NOR activity. This study presents a novel protein model of NOR and provides insights into a newly discovered member of the NOR family, gNOR.

  8. Galactic Center gamma-ray "excess" from an active past of the Galactic Centre?

    CERN Document Server

    Petrovic, Jovana; Zaharijas, Gabrijela

    2014-01-01

    Several groups have recently claimed evidence for unaccounted gamma-ray excesses over diffuse backgrounds at few GeV in Fermi-LAT data in a region around the Galactic Center, consistent with a dark matter annihilation origin. We demonstrate that the main spectral and angular features of this "excess" can be reproduced if they are mostly due to inverse Compton emission from high-energy electrons injected in a burst event of ~ 10^{52}-10^{53} erg roughly O(10^6) years ago. We consider this example as a proof of principle that time-dependent phenomena need to be understood and accounted for---together with detailed diffuse foregrounds and unaccounted "steady state" astrophysical sources---before any robust inference can be made about dark matter signals at the Galactic Center. In addition, we point out that the timescale suggested by our study, which controls both the energy cutoff and the angular extension of the signal, intriguingly matches what is inferred by other forensic evidences suggesting a very active ...

  9. Functional Magnetic Resonance Imaging of Different Genders in the Activation of Brain Emotional Centers

    Directory of Open Access Journals (Sweden)

    L. Podsiadło

    2011-05-01

    Full Text Available Background/Objective: The main aim of this study"nwas to reveal gender differences in the localization"nof brain emotional centers for positive and negative"nstimuli."nPatients and Methods: Forty right-handed young"nvolunteers (age range, 18-36 years, 21 men and 19"nwomen were examined using MR 1.5 T Signa Horizon"n(GEMS. Functional images were acquired using a"nspin-echo echoplanar sequence sensitive to blood"noxygenation level dependent (BOLD contrast, with"nthe following parameters: TR=3000 ms, TE= 60 ms,"nFOV=2821 cm, matrix 9696,1 NEX. For emotion induction, affectively negative, positive and neutral"npictures were used. Positive and negative cues were"ntaken from the International Affecive Picture System"n(IAPS. There were two runs, in the first run subjects"nsaw only negatively valenced pictures, during the"nsecond run only positive pictures were shown."nResults: For positive stimuli, the greatest differences"nin activation in women compared to men were"ndetected in the right superior temporal gyrus. For"nnegative stimuli, the greatest differences in activation"nin women compared to men were detected in the left"nthalamus. For positive stimuli, the greatest differences"nin activation in men compared to women were"ndetected in the bilateral occipital lobes as well as the"nbilateral fusiform gyrus. For negative stimuli, the"ngreatest differences in activation in men compared to"nwomen were detected in the left insula."nConclusion: There are statistically significant"ndifferences in activation of the emotional centers"nbetween females and males for the positive and"ndenoised, extracted and visualized. Follow-up CT"nexam and/or clinical pictures confirmed or excluded"nthe diagnosis. Based on preliminary results and"nconcluded efficiency limitations additional postprocessing"nbased on curvelets decomposition and"nimproved segmentation of stroke susceptible regions"nhas been designed and performed later on for selected"nexaminations regarded as

  10. Stereoselective bimolecular phenoxyl radical coupling by an auxiliary (dirigent) protein without an active center

    Energy Technology Data Exchange (ETDEWEB)

    Davin, L.B.; Wang, Huai-Bin; Crowell, A.L. [Washington State Univ., Pullman, WA (United States)] [and others

    1997-01-17

    The regio- and stereospecificity of bimolecular phenoxy radical coupling reactions, of especial importance in lignin and lignan biosynthesis, are clearly controlled in some manner in vivo; yet in vitro coupling by oxidases, such as laccases, only produce racemic products. In other words, laccases, peroxidases, and comparable oxidases are unable to control regio- or stereospecificity by themselves and thus some other agent must exist. A 78-kilodalton protein has been isolated that, in the presence of an oxidase or one electron oxidant, effects stereoselective bimolecular phenoxy radical coupling in vitro. Itself lacking a catalytically active (oxidative) center, its mechanism of action is presumed to involve capture of E-coniferyl alcohol-derived free-radical intermediates, with consequent stereoselective coupling to give (+)-pinoresinol. 25 refs., 6 figs., 3 tabs.

  11. Implicit trustworthiness ratings of self-resembling faces activate brain centers involved in reward.

    Science.gov (United States)

    Platek, Steven M; Krill, Austen L; Wilson, Benjamin

    2009-01-01

    On the basis of Hamilton's (Hamilton, W. D. (1964). The genetical evolution of social behavior I, II. Journal of Theoretical Biology, 7, 17-52) theory of inclusive fitness, self-facial resemblance is hypothesized as a mechanism for self-referent phenotypic matching by which humans can detect kin. To understand the mechanisms underlying pro-sociality toward self-resembling faces, we investigated the neural correlates of implicit trustworthiness ratings for self-resembling faces. Here we show that idiosyncratic trustworthiness ratings of self-resembling faces predict brain activation in the ventral inferior, middle and medial frontal gyri, substrates involved in reward processing. These findings demonstrate that neural reward centers are implicated in evaluating implicit pro-social behaviors toward self-resembling faces. These findings suggest that humans have evolved to use neurocomputational architecture dedicated to face processing and reward evaluation for the differentiation of kin, which drives implicit idiosyncratic affectively regulated social interactions. PMID:18761362

  12. Senior Centers

    Medline Plus

    Full Text Available ... variety of social and recreational activities. [Karen Albers] We provide a wide variety of activities -- physical, health, ... senior centers also offer exercise programs. [Karen Albers] We offer aerobics, tai chi, tap dancing, ballroom dancing, ...

  13. Overview of the National Atmospheric Release Advisory Center's urban research and development activities

    International Nuclear Information System (INIS)

    This presentation describes the tools and services provided by the National Atmospheric Release Advisory Center (NARAC) at Lawrence Livermore National Laboratory (LLNL) for modeling the impacts of airborne hazardous materials. NARAC provides atmospheric plume modeling tools and services for chemical, biological, radiological, and nuclear airborne hazards. NARAC can simulate downwind effects from a variety of scenarios, including fires, industrial and transportation accidents, radiation dispersal device explosions, hazardous material spills, sprayers, nuclear power plant accidents, and nuclear detonations. NARAC collaborates on radiological dispersion source terms and effects models with Sandia National Laboratories and the U.S. Nuclear Regulatory Commission. NARAC was designated the interim provider of capabilities for the Department of Homeland Security's Interagency Modeling and Atmospheric Assessment Center by the Homeland Security Council in April 2004. The NARAC suite of software tools include simple stand-alone, local-scale plume modeling tools for end-user's computers, and Web- and Internet-based software to access advanced modeling tools and expert analyses from the national center at LLNL. Initial automated, 3-D predictions of plume exposure limits and protective action guidelines for emergency responders and managers are available from the center in 5-10 minutes. These can be followed immediately by quality-assured, refined analyses by 24 x 7 on-duty or on-call NARAC staff. NARAC continues to refine calculations using updated on-scene information, including measurements, until all airborne releases have stopped and the hazardous threats are mapped and impacts assessed. Model predictions include the 3-D spatial and time-varying effects of weather, land use, and terrain, on scales from the local to regional to global. Real-time meteorological data and forecasts are provided by redundant communications links to the U.S. National Oceanic and Atmospheric

  14. Overview of the National Atmospheric Release Advisory Center's Urban Research and Development Activities

    Science.gov (United States)

    Lundquist, J. K.; Sugiyama, G.; Nasstrom, J.

    2007-12-01

    This presentation describes the tools and services provided by the National Atmospheric Release Advisory Center (NARAC) at Lawrence Livermore National Laboratory (LLNL) for modeling the impacts of airborne hazardous materials. NARAC provides atmospheric plume modeling tools and services for chemical, biological, radiological, and nuclear airborne hazards. NARAC can simulate downwind effects from a variety of scenarios, including fires, industrial and transportation accidents, radiation dispersal device explosions, hazardous material spills, sprayers, nuclear power plant accidents, and nuclear detonations. NARAC collaborates on radiological dispersion source terms and effects models with Sandia National Laboratories and the U.S. Nuclear Regulatory Commission. NARAC was designated the interim provider of capabilities for the Department of Homeland Security's Interagency Modeling and Atmospheric Assessment Center by the Homeland Security Council in April 2004. The NARAC suite of software tools include simple stand-alone, local-scale plume modeling tools for end-user's computers, and Web- and Internet-based software to access advanced modeling tools and expert analyses from the national center at LLNL. Initial automated, 3-D predictions of plume exposure limits and protective action guidelines for emergency responders and managers are available from the center in 5-10 minutes. These can be followed immediately by quality-assured, refined analyses by 24 x 7 on-duty or on-call NARAC staff. NARAC continues to refine calculations using updated on-scene information, including measurements, until all airborne releases have stopped and the hazardous threats are mapped and impacts assessed. Model predictions include the 3-D spatial and time-varying effects of weather, land use, and terrain, on scales from the local to regional to global. Real-time meteorological data and forecasts are provided by redundant communications links to the U.S. National Oceanic and Atmospheric

  15. Effects of supported metallocene catalyst active center multiplicity on antioxidant-stabilized ethylene homo- and copolymers

    KAUST Repository

    Atiqullah, Muhammad

    2014-10-09

    © 2014 Akadémiai Kiadó, Budapest, Hungary. A silica-supported bis(n-butylcyclopentadienyl) zirconium dichloride [( n BuCp)2ZrCl2] catalyst was synthesized. This was used to prepare an ethylene homopolymer and an ethylene-1-hexene copolymer. The active center multiplicity of this catalyst was modeled by deconvoluting the copolymer molecular mass distribution and chemical composition distribution. Five different active site types were predicted, which matched the successive self-nucleation and annealing temperature peaks. The thermo-oxidative melt stability, with and without Irganox 1010 and Irgafos 168, of the above polyethylenes was investigated using nonisothermal differential scanning calorimetric (DSC) experiments at 150 °C. This is a temperature that ensures complete melting of the samples and avoids the diffusivity of oxygen to interfere into polyethylene crystallinity and its thermo-oxidative melt degradation. The oxidation parameters such as onset oxidation temperature, induction period, protection factor, and S-factor were determined by combining theoretical modeling with the DSC experiments. Subsequently, these findings were discussed considering catalyst active center multiplicity and polymer microstructure, particularly average ethylene sequence length. Several insightful results, which have not been reported earlier in the literature, were obtained. The antioxidant effect, for each polymer, varied as (Irganox + Irgafos) ≈ Irganox > Irgafos > Neat polymer. The as-synthesized homopolymer turned out to be almost twice as stable as the corresponding copolymer. The antioxidant(s) in the copolymer showed higher antioxidant effectiveness (AEX) than those in the homopolymer. Irganox exhibited more AEX than Irgafos. To the best of our knowledge, such findings have not been reported earlier in the literature. However, mixed with Irganox or Irgafos, their melt oxidation stability was comparable. The homopolymer, as per the calculated S-factor, showed Irganox

  16. PERSON-CENTERED AND PERSON-ACTIVITY APPROACH AS A BASIS OF INTEGRATIVE LANGUAGE TEACHING TECHNOLOGY

    Directory of Open Access Journals (Sweden)

    Yulia N. KARPOVA

    2015-01-01

    Full Text Available The article touches upon one of the most acute and complex problems of the modern Russian society the problem of reforming the current system of professional education. The author emphasizes the fact that person – centered and person-activity approach should be the key elements in higher education system modernization as a student personality and his future professional activity should be highlighted in the process of education and upbringing. The author has developed and successfully implemented the integrative language teaching technology, which unites both linguistic and religious knowledge. The article provides a detailed description of the main stages of the process of the technology introduction, the literature and the video materials that were used in the course of the technology implementation in the educational process, as well as formulates conclusions at each stage of its implementation. The effectiveness of the integrative language teaching technology has been proven and is defined by the author as the effect of pedagogical synergy of mutual interaction of several disciplines, characterized by the fact that the influence of the tech nology use exceeds the influence exerted by each discipline as the component of the educational process taken separately.

  17. A parallelogram-based compliant remote-center-of-motion stage for active parallel alignment

    Science.gov (United States)

    Qu, Jianliang; Chen, Weihai; Zhang, Jianbin

    2014-09-01

    Parallel alignment stage with remote-center-of-motion (RCM) is of key importance in precision out-of-plane aligning since it can eliminate the harmful lateral displacement generated at the output platform. This paper presents the development of a parallelogram-based compliant RCM stage for active parallel alignment. Different from conventional parallelogram-based RCM mechanism, the proposed stage is designed with compliant mechanisms, which endows the stage with many attractive merits when used in precision micro-/nanomanipulations. A symmetric double-parallelogram mechanism (SDPM) based on flexure hinges is developed as the rotary guiding component to realize desired RCM function. Due to the geometrical constraint of the SDPM, the operating space of the stage can be easily adjusted by bending the input links without loss of rotational precision. The stage is driven by a piezoelectric actuator and its output motion is measured by non-contact displacement sensors. Based on pseudo-rigid-body simplification method, the analytical models predicting kinematics, statics, and dynamics of the RCM stage have been established. Besides, the dimensional optimization is conducted in order to maximize the first resonance frequency of the stage. After that, finite element analysis is conducted to validate the established models and the prototype of the stage is fabricated for performance tests. The experimental results show that the developed RCM stage has a rotational range of 1.45 mrad while the maximum center shift of the RCM point is as low as 1 μm, which validate the effectiveness of the proposed scheme.

  18. Cloud Computing Applications in Support of Earth Science Activities at Marshall Space Flight Center

    Science.gov (United States)

    Molthan, Andrew L.; Limaye, Ashutosh S.; Srikishen, Jayanthi

    2011-01-01

    Currently, the NASA Nebula Cloud Computing Platform is available to Agency personnel in a pre-release status as the system undergoes a formal operational readiness review. Over the past year, two projects within the Earth Science Office at NASA Marshall Space Flight Center have been investigating the performance and value of Nebula s "Infrastructure as a Service", or "IaaS" concept and applying cloud computing concepts to advance their respective mission goals. The Short-term Prediction Research and Transition (SPoRT) Center focuses on the transition of unique NASA satellite observations and weather forecasting capabilities for use within the operational forecasting community through partnerships with NOAA s National Weather Service (NWS). SPoRT has evaluated the performance of the Weather Research and Forecasting (WRF) model on virtual machines deployed within Nebula and used Nebula instances to simulate local forecasts in support of regional forecast studies of interest to select NWS forecast offices. In addition to weather forecasting applications, rapidly deployable Nebula virtual machines have supported the processing of high resolution NASA satellite imagery to support disaster assessment following the historic severe weather and tornado outbreak of April 27, 2011. Other modeling and satellite analysis activities are underway in support of NASA s SERVIR program, which integrates satellite observations, ground-based data and forecast models to monitor environmental change and improve disaster response in Central America, the Caribbean, Africa, and the Himalayas. Leveraging SPoRT s experience, SERVIR is working to establish a real-time weather forecasting model for Central America. Other modeling efforts include hydrologic forecasts for Kenya, driven by NASA satellite observations and reanalysis data sets provided by the broader meteorological community. Forecast modeling efforts are supplemented by short-term forecasts of convective initiation, determined by

  19. Integrating Field-Centered, Project Based Activities with Academic Year Coursework: A Curriculum Wide Approach

    Science.gov (United States)

    Kelso, P. R.; Brown, L. M.

    2015-12-01

    Based upon constructivist principles and the recognition that many students are motivated by hands-on activities and field experiences, we designed a new undergraduate curriculum at Lake Superior State University. One of our major goals was to develop stand-alone field projects in most of the academic year courses. Examples of courses impacted include structural geology, geophysics, and geotectonics, Students learn geophysical concepts in the context of near surface field-based geophysical studies while students in structural geology learn about structural processes through outcrop study of fractures, folds and faults. In geotectonics students learn about collisional and rifting processes through on-site field studies of specific geologic provinces. Another goal was to integrate data and samples collected by students in our sophomore level introductory field course along with stand-alone field projects in our clastic systems and sequence stratigraphy courses. Our emphasis on active learning helps students develop a meaningful geoscience knowledge base and complex reasoning skills in authentic contexts. We simulate the activities of practicing geoscientists by engaging students in all aspects of a project, for example: field-oriented project planning and design; acquiring, analyzing, and interpreting data; incorporating supplemental material and background data; and preparing oral and written project reports. We find through anecdotal evidence including student comments and personal observation that the projects stimulate interest, provide motivation for learning new concepts, integrate skill and concept acquisition vertically through the curriculum, apply concepts from multiple geoscience subdisiplines, and develop soft skills such as team work, problem solving, critical thinking and communication skills. Through this projected-centered Lake Superior State University geology curriculum students practice our motto of "learn geology by doing geology."

  20. Nutrition and physical activity randomized control trial in child care centers improves knowledge, policies, and children's body mass index.

    OpenAIRE

    Alkon, A; Crowley, AA; Neelon, SE; Hill, S.; Pan, Y.; Nguyen, V.; Rose, R.; Savage, E; Forestieri, N; Shipman, L; Kotch, JB

    2014-01-01

    BACKGROUND: To address the public health crisis of overweight and obese preschool-age children, the Nutrition And Physical Activity Self Assessment for Child Care (NAP SACC) intervention was delivered by nurse child care health consultants with the objective of improving child care provider and parent nutrition and physical activity knowledge, center-level nutrition and physical activity policies and practices, and children's body mass index (BMI). METHODS: A seven-month randomized control tr...

  1. Job center

    Science.gov (United States)

    To better meet the needs of AGU members, a program has been started to increase the effectiveness of the Job Center activity at the Spring and Fall Meetings. As a result, participation in the Job Center at the 1988 AGU Spring Meeting in Baltimore increased substantially compared to previous Spring Meetings. The number of employers, applicants, and interviews scheduled more than doubled compared to the 1987 Spring Job Center.In order to make the meeting Job Centers even better, a survey is being conducted of employers and applicants who participated in the 1988 Spring Job Center. Evaluation of this survey will be useful in continuing increased participation in and the effectiveness of the Job Center at the 1988 Fall Meeting. Past participants and those interested in the future of the Job Center are encouraged to forward comments and suggestions to AGU, Member Programs Division, 2000 Florida Ave., N.W., Washington, DC 20009.

  2. Probing the Active Massive Black Hole Candidate in the Center of NGC 404 with VLBI

    CERN Document Server

    Paragi, Z; Kaaret, P; Cseh, D; Overzier, R; Kharb, P

    2014-01-01

    Recently Nyland et al. (2012) argued that the radio emission observed in the center of the dwarf galaxy NGC 404 originates in a low-luminosity active galactic nucleus (LLAGN) powered by a massive black hole ($M\\sim<10^6$ M$_{\\odot}$). High-resolution radio detections of MBHs are rare. Here we present sensitive, contemporaneous Chandra X-ray, and very long baseline interferometry (VLBI) radio observations with the European VLBI Network (EVN). The source is detected in the X-rays, and shows no long-term variability. If the hard X-ray source is powered by accretion, the apparent low accretion efficiency would be consistent with a black hole in the hard state. Hard state black holes are known to show radio emission compact on the milliarcsecond scales. However, the central region of NGC 404 is resolved out on 10 milliarcsecond (0.15-1.5 pc) scales. Our VLBI non-detection of a compact, partially self-absorbed radio core in NGC 404 implies that either the black hole mass is smaller than $3^{+5}_{-2}\\times10^5$ M...

  3. Overview of the 1985 NASA Lewis Research Center SP-100 free-piston stirling engine activities

    International Nuclear Information System (INIS)

    An overview of the 1985 (NASA) Lewis Research Center free-piston Stirling engine activities in support of the SP-100 Program is presented. The SP-100 program is being conducted in support of the Department of Advanced Research Projects Agency (DARPA) and the Department of Energy (DOE), and NASA. This effort is keyed on the design, fabrication, assembly, and testing of a 25 kW /SUB e/ Stirling space-power technology-feasibility demonstrator engine. Another facet of the SP-100 project covers the status of a 9000-hr goal endurance test conducted on a 2 kW /SUB e/ free-piston Stirling/ linear alternator system employing hydrostatic gas bearings. Dynamic balancing of the RE-1000 engine (a 1 kW /SUB e/ free-piston Stirling engine) using a passive dynamic absorber will be discussed along with the results of a parametric study showing the relationships of Stirling power converter specific weight and efficiency as functions of Stirling engine heater to cooler temperature ratio. Planned tests will be described covering a hydrodynamic gas bearing concept for potential SP-100 application

  4. Bioprocess-centered molecular design (BMD) for the efficient production of an interfacially active peptide.

    Science.gov (United States)

    Morreale, Giacomo; Lee, Eun Gyo; Jones, Daniel B; Middelberg, Anton P J

    2004-09-30

    The efficient expression and purification of an interfacially active peptide (mLac21) was achieved by using bioprocess-centered molecular design (BMD), wherein key bioprocess considerations are addressed during the initial molecular biology work. The 21 amino acid mLac21 peptide sequence is derived from the lac repressor protein and is shown to have high affinity for the oil-water interface, causing a substantial reduction in interfacial tension following adsorption. The DNA coding for the peptide sequence was cloned into a modified pET-31(b) vector to permit the expression of mLac21 as a fusion to ketosteroid isomerase (KSI). Rational iterative molecular design, taking into account the need for a scaleable bioprocess flowsheet, led to a simple and efficient bioprocess yielding mLac21 at 86% purity following ion exchange chromatography (and >98% following chromatographic polishing). This case study demonstrates that it is possible to produce acceptably pure peptide for potential commodity applications using common scaleable bioprocess unit operations. Moreover, it is shown that BMD is a powerful strategy that can be deployed to reduce bioseparation complexity.

  5. The Student-Centered Active Learning Environment for Undergraduate Programs (SCALE-UP) Project

    Science.gov (United States)

    Beichner, Robert J.

    2011-04-01

    How do you keep a classroom of 100 undergraduates actively learning? Can students practice communication and teamwork skills in a large class? How do you boost the performance of underrepresented groups? The Student-Centered Active Learning Environment for Undergraduate Programs (SCALE-UP) Project has addressed these concerns. Because of their inclusion in a leading introductory physics textbook, project materials are used by more than 1/3 of all science, math, and engineering majors nationwide. The room design and pedagogy have been adopted at more than 100 leading institutions across the country. Physics, chemistry, math, astronomy, biology, engineering, earth sciences, and even literature classes are currently being taught this way. Educational research indicates that students should collaborate on interesting tasks and be deeply involved with the material they are studying. We promote active learning in a redesigned classroom for 100 students or more. (Of course, smaller classes can also benefit.) Class time is spent primarily on "tangibles" and "ponderables"--hands-on activities, simulations, and interesting questions. Nine students sit in three teams at round tables. Instructors circulate and engage in Socratic dialogues. The setting looks like a banquet hall, with lively interactions nearly all the time. Hundreds of hours of classroom video and audio recordings, transcripts of numerous interviews and focus groups, data from conceptual learning assessments (using widely-recognized instruments in a pretest/posttest protocol), and collected portfolios of student work are part of our rigorous assessment effort. Our findings (based on data from over 16,000 students collected over five years as well as replications at adopting sites) can be summarized as the following: 1) Female failure rate is 1/5 of previous levels, even though more is demanded of students. 2) Minority failure rate is 1/4 that seen in traditionally taught courses. 3) At-risk students are more

  6. Development of a national center for hydrogen technology. A summary report of activities completed at the national center hydrogen technology from 2005 to 2010

    Energy Technology Data Exchange (ETDEWEB)

    Holmes, Michael J. [Univ. of North Dakota, Grand Forks, ND (United States)

    2011-06-01

    The Energy & Environmental Research Center (EERC) located in Grand Forks, North Dakota, has operated the National Center for Hydrogen Technology® (NCHT®) since 2005 under a Cooperative Agreement with the U.S. Department of Energy's (DOE) National Energy Technology Laboratory (NETL). The EERC has a long history of hydrogen generation and utilization from fossil fuels, and under the NCHT Program, the EERC has accelerated its research of hydrogen generation and utilization topics. Since the NCHT's inception, the EERC has received more than $65 million in funding of hydrogen-related projects ($20 million for the NCHT project which includes federal and corporate development partner funds) involving more than 85 partners (27 with the NCHT). The NCHT project's 19 activities span a broad range of technologies that align well with the Advanced Fuels Program goals and, specifically, those described in the Hydrogen from Coal Program research, development, and demonstration (RD&D) plan. A number of projects have been completed which range from technical feasibility of several hydrogen generation and utilization technologies to public and technical education and outreach tools. Projects under the NCHT have produced hydrogen from natural gas, coal, liquid hydrocarbons, and biomass. The hydrogen or syngas generated by these processes has also been purified to transportation-grade quality in many of these instances or burned directly for power generation. Also, several activities are still undergoing research, development, demonstration, and commercialization at the NCHT. This report provides a summary overview of the projects completed in the first 5 years of the NCHT. Individual activity reports are referenced as a source of detailed information on each activity.

  7. Development of a National Center for Hydrogen Technology. A Summary Report of Activities Completed at the National Center for Hydrogen Technology - Year 6

    Energy Technology Data Exchange (ETDEWEB)

    Holmes, Michael [Univ. of North Dakota, Grand Forks, ND (United States)

    2012-08-01

    The Energy & Environmental Research Center (EERC) located in Grand Forks, North Dakota, has operated the National Center for Hydrogen Technology (NCHT) since 2005 under a Cooperative Agreement with the U.S. Department of Energy (DOE) National Energy Technology Laboratory (NETL). The EERC has a long history of hydrogen generation and utilization from fossil fuels, and under the NCHT Program, the EERC has accelerated its research on hydrogen generation and utilization topics. Since the NCHT's inception, the EERC has received more than $65 million in funding for hydrogen-related projects ($24 million for projects in the NCHT, which includes federal and corporate partner development funds) involving more than 85 partners (27 with the NCHT). The NCHT Program's nine activities span a broad range of technologies that align well with the Advanced Fuels Program goals and, specifically, those described in the Hydrogen from Coal Program research, development, and demonstration (RD&D) plan that refers to realistic testing of technologies at adequate scale, process intensification, and contaminant control. A number of projects have been completed that range from technical feasibility of several hydrogen generation and utilization technologies to public and technical education and outreach tools. Projects under the NCHT have produced hydrogen from natural gas, coal, liquid hydrocarbons, and biomass. The hydrogen or syngas generated by these processes has also been purified in many of these instances or burned directly for power generation. Also, several activities are still undergoing research, development, demonstration, and commercialization at the NCHT. This report provides a summary overview of the projects completed in Year 6 of the NCHT. Individual activity reports are referenced as a source of detailed information on each activity.

  8. Department of Energy Support for Operations of the WMO/GAW Quality Control/Science Activity Center for the Americas

    Energy Technology Data Exchange (ETDEWEB)

    Hicks, B. B.

    2003-11-13

    As a formal activity of the World Meteorological Organization's Global Atmosphere Watch, to provide, through agency collaboration, a center of excellence in the United States that would impose quality assurance techniques on data collected by national air and precipitation quality networks operating in the Americas (north, south, and central).

  9. Efficacy of a Web-Based, Center-Based or Combined Physical Activity Intervention among Older Adults

    Science.gov (United States)

    Mouton, Alexandre; Cloes, Marc

    2015-01-01

    With more social support and environment-centered interventions being recommended in web-based interventions, this study examined the efficacy of three intervention conditions aimed at promoting physical activity (PA) in older adults. The efficacy analyses included the self-reported PA level, stage of change for PA and awareness about PA among…

  10. Senior Centers

    Medline Plus

    Full Text Available ... Karen Albers] We provide a wide variety of activities -- physical, health, mental health programs with Senior Plus, cognitive ... of games. [Narrator] Many senior centers also offer exercise programs. [Karen Albers] We offer aerobics, tai chi, ...

  11. Discovery boxes for active spending of free time in the center for children and youth with special needs

    OpenAIRE

    Brbre, Irena

    2012-01-01

    Children and young people with minor mental health disorder who stay in the centers for children and youth with special needs, spend their free time in different ways. They have the option to take part in various extra-curricular activities depending on their interests, wishes, needs and abilities. I believe that one of such active spending of free time is also work with discovery boxes where children and young people can develop natural-historical procedures with their own experiences and ob...

  12. GOES-R Proving Ground Activities at the NASA Short-Term Prediction Research and Transition (SPoRT) Center

    Science.gov (United States)

    Molthan, Andrew

    2011-01-01

    SPoRT is actively involved in GOES-R Proving Ground activities in a number of ways: (1) Applying the paradigm of product development, user training, and interaction to foster interaction with end users at NOAA forecast offices national centers. (2) Providing unique capabilities in collaboration with other GOES-R Proving Ground partners (a) Hybrid GOES-MODIS imagery (b) Pseudo-GLM via regional lightning mapping arrays (c) Developing new RGB imagery from EUMETSAT guidelines

  13. Web Services Implementations at Land Process and Goddard Earth Sciences Distributed Active Archive Centers

    Science.gov (United States)

    Cole, M.; Bambacus, M.; Lynnes, C.; Sauer, B.; Falke, S.; Yang, W.

    2007-12-01

    NASA's vast array of scientific data within its Distributed Active Archive Centers (DAACs) is especially valuable to both traditional research scientists as well as the emerging market of Earth Science Information Partners. For example, the air quality science and management communities are increasingly using satellite derived observations in their analyses and decision making. The Air Quality Cluster in the Federation of Earth Science Information Partners (ESIP) uses web infrastructures of interoperability, or Service Oriented Architecture (SOA), to extend data exploration, use, and analysis and provides a user environment for DAAC products. In an effort to continually offer these NASA data to the broadest research community audience, and reusing emerging technologies, both NASA's Goddard Earth Science (GES) and Land Process (LP) DAACs have engaged in a web services pilot project. Through these projects both GES and LP have exposed data through the Open Geospatial Consortiums (OGC) Web Services standards. Reusing several different existing applications and implementation techniques, GES and LP successfully exposed a variety data, through distributed systems to be ingested into multiple end-user systems. The results of this project will enable researchers world wide to access some of NASA's GES & LP DAAC data through OGC protocols. This functionality encourages inter-disciplinary research while increasing data use through advanced technologies. This paper will concentrate on the implementation and use of OGC Web Services, specifically Web Map and Web Coverage Services (WMS, WCS) at GES and LP DAACs, and the value of these services within scientific applications, including integration with the DataFed air quality web infrastructure and in the development of data analysis web applications.

  14. Attending an activity center: positive experiences of a group of home-dwelling persons with early-stage dementia

    Directory of Open Access Journals (Sweden)

    Söderhamn U

    2014-11-01

    Full Text Available Ulrika Söderhamn,1 Live Aasgaard,2 Bjørg Landmark2,3 1Centre for Caring Research Southern Norway, Faculty of Health and Sport Sciences, University of Agder, Grimstad, 2Institute of Research and Development for Nursing and Care Services, Municipality of Drammen, 3Faculty of Health, Buskerud and Vestfold University College, Drammen, Norway Background: In Norway, there is a focus on home-dwelling people with dementia receiving the opportunity to participate in organized meaningful activities. The aim of this study was to elucidate the experiences of home-dwelling persons with early-stage dementia who attend an activity center and participate in adapted physical and social activities delivered by nurses and volunteers.Methods: The study adopted a qualitative approach, with individual interviews conducted among eight people diagnosed with early-stage dementia. The interview texts were analyzed using manifest and latent content analysis.Results: Four categories, ie, “appreciated activities”, “praised nurses and volunteers”, “being more active”, and “being included in a fellowship”, as well as the overall theme “participation in appreciated activities and a sense of feeling included in a fellowship may have a positive influence on health and well-being” emerged in the analysis. The informants appreciated the adapted physical and social activities and expressed their enjoyment and gratitude. They found the physical activities useful, and they felt themselves to be included in a fellowship through cheerful nurses and volunteers. The nurses were able to create a good atmosphere and spread joy in the center together with the volunteers. The informants felt themselves valued as the persons they were. These findings indicated that such activities may have had a positive influence on the informants’ health and well-being.Conclusion: In order to succeed with this kind of activity center, it is decisive that the nurses are able to

  15. Spent fuel storage facility at science and technical center 'Sosny': Experience of ten years activity

    International Nuclear Information System (INIS)

    Spent fuel storage of the Academic Science and Technical Center in Minsk is in operation already more then 10 years. In the paper aspects of its design, operation practice, problems and decisions for future are discussed. (author)

  16. Evaluation of recombinant activated protein C for severe sepsis at a tertiary academic medical center

    Directory of Open Access Journals (Sweden)

    Anger KE

    2013-06-01

    Full Text Available Kevin E Anger,1 Jeremy R DeGrado,1 Bonnie C Greenwood,1 Steven A Cohen,2 Paul M Szumita1 1Department of Pharmacy, Brigham and Women’s Hospital, Boston, MA, USA; 2Department of Family Medicine and Population Health, Division of Epidemiology, Virginia Commonwealth University, Richmond, VA, USA Purpose: Early clinical trials of recombinant human activated protein C (rhAPC for severe sepsis excluded patients at high risk of bleeding. Recent literature suggests bleeding rates are higher in clinical practice and may be associated with worsened outcomes. Our objective was to evaluate baseline demographics; incidence, and risk factors for major bleeding; and mortality of patients receiving rhAPC for severe sepsis at our institution. Methods: A retrospective study was performed for all patients receiving rhAPC for treatment of severe sepsis at a tertiary academic medical center from January 2002 to June 2009. Demographic information, clinical variables, intensive care unit, and hospital outcomes were recorded. Results: Of the 156 patients that received rhAPC, 54 (34.6% did not meet institutional criteria for safe use at baseline due to bleeding precaution or contraindication. Twenty-three (14.7% patients experienced a major bleeding event. Multivariate analysis demonstrated baseline International Normalized Ratio ≥2.5 (odds ratio [OR] 3.68, 95% confidence interval [CI]: 1.28–10.56; P = 0.03 and platelet count ≤100 × 103/mm3 (OR 2.86, 95% CI: 1.07–7.67; P = 0.01 as significant predictors of a major bleed. Overall hospital mortality was 57.7%. Multivariate analysis demonstrated the presence of ≥3 organ dysfunctions (OR 2.46, 95% CI: 1.19–5.09; P < 0.05 and medical intensive care unit admission (OR 1.99, 95% CI: 1.00–3.98; P = 0.05 were independent variables associated with hospital mortality. Conclusion: Patients receiving rhAPC at our institution had higher APACHE II scores, mortality, and major bleeding events than published

  17. Binding of nitrite and its reductive activation to nitric oxide at biomimetic copper centers.

    Science.gov (United States)

    Monzani, E; Anthony, G J; Koolhaas, A; Spandre, A; Leggieri, E; Casella, L; Gullotti, M; Nardin, G; Randaccio, L; Fontani, M; Zanello, P; Reedijk, J

    2000-04-01

    The reactivity of nitrite towards the copper(II) and copper(I) centers of a series of complexes with tridentate nitrogen donor ligands has been investigated. The ligands are bis[(1-methylbenzimidazol-2-yl)methyl]amine (1-bb), bis[2-(1-methylbenzimidazol-2-yl)ethyl]amine (2-bb), and bis[2-(3,5-dimethyl-1-pyrazolyl)ethyl]amine (ddah) and carry two terminal benzimidazole (1-bb, 2-bb) or pyrazole (ddah) rings and a central amine donor residue. While 2-bb and ddah form two adjacent six-membered chelate rings on metal coordination, 1-bb forms two smaller rings of five members. The binding affinity of nitrite and azide to the Cu(II) complexes (ClO4- as counterion) has been determined in solution. The association constants for the two ligands are similar, but nitrite is a slightly stronger ligand than azide when it binds as a bidentate donor. The X-ray crystal structure of the nitrite complex [Cu(ddah)(NO2)]ClO4 (final R=0.056) has been determined: triclinic P1space group, a=8.200(2) A, b=9.582(3) A, c=15.541(4) A. It may be described as a perchlorate salt of a "supramolecular" species resulting from the assembly of two complex cations and one sodium perchlorate unit. The copper stereochemistry in the complex is intermediate between SPY and TBP, and nitrite binds to Cu(II) asymmetrically, with Cu-O distances of 2.037(2) and 2.390(3) A and a nearly planar CuO2N cycle. On standing, solutions of [Cu(ddah)(NO2)]ClO4 in methanol produce the dinuclear complex [Cu(ddah)(OMe)]2(ClO4)2, containing dibridging methoxy groups. In fact the crystal structure analysis (final R=0.083) showed that the crystals are built up by dinuclear cations, arranged on a crystallographic symmetry center, and perchlorate anions. Electrochemical analysis shows that binding of nitrite to the Cu(II) complexes of 2-bb and ddah shifts the reduction potential of the Cu(II)/Cu(I) couple towards negative values by about 0.3 V. The thermodynamic parameters of the Cu(II)/Cu(I) electron transfer have also been

  18. Construction of GPx active centers on natural protein nanodisk/nanotube: a new way to develop artificial nanoenzyme.

    Science.gov (United States)

    Hou, Chunxi; Luo, Quan; Liu, Jinliang; Miao, Lu; Zhang, Chunqiu; Gao, Yuzhou; Zhang, Xiyu; Xu, Jiayun; Dong, Zeyuan; Liu, Junqiu

    2012-10-23

    Construction of catalytic centers on natural protein aggregates is a challenging topic in biomaterial and biomedicine research. Here we report a novel construction of artificial nanoenzyme with glutathione peroxidase (GPx)-like function. By engineering the surface of tobacco mosaic virus (TMV) coat protein, the main catalytic components of GPx were fabricated on TMV protein monomers. Through direct self-assembly of the functionalized viral coat proteins, the multi-GPx centers were installed on these well-defined nanodisks or nanotubes. With the help of muti-selenoenzyme centers, the resulting organized nanoenzyme exhibited remarkable GPx activity, even approaching the level of natural GPx. The antioxidation study on subcell mitochondrial level demonstrated that virus-based nanoenzyme exerted excellent capacity for protecting cell from oxidative damage. This strategy represents a new way to develop artificial nanoenzymes. PMID:22992167

  19. Quality-assurance and data-management plan for water-quality activities in the Kansas Water Science Center, 2014

    Science.gov (United States)

    Rasmussen, Teresa J.; Bennett, Trudy J.; Foster, Guy M.; Graham, Jennifer L.; Putnam, James E.

    2014-01-01

    As the Nation’s largest water, earth, and biological science and civilian mapping information agency, the U.S. Geological Survey is relied on to collect high-quality data, and produce factual and impartial interpretive reports. This quality-assurance and data-management plan provides guidance for water-quality activities conducted by the Kansas Water Science Center. Policies and procedures are documented for activities related to planning, collecting, storing, documenting, tracking, verifying, approving, archiving, and disseminating water-quality data. The policies and procedures described in this plan complement quality-assurance plans for continuous water-quality monitoring, surface-water, and groundwater activities in Kansas.

  20. Idaho Nuclear Technology and Engineering Center Low-Activity Waste Process Technology Program FY-98 Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Herbst, Alan Keith; Mc Cray, John Alan; Rogers, Adam Zachary; Simmons, R. F.; Palethorpe, S. J.

    1999-03-01

    The Low-Activity Waste Process Technology Program at the Idaho Nuclear Technology and Engineering Center (INTEC) anticipates that large volumes of low-level/low-activity wastes will need to be grouted prior to near-surface disposal. During fiscal year 1998, three grout formulations were studied for low-activity wastes derived from INTEC liquid sodium-bearing waste. Compressive strength and leach results are presented for phosphate bonding cement, acidic grout, and alkaline grout formulations. In an additional study, grout formulations are recommended for stabilization of the INTEC underground storage tank residual heels.

  1. Idaho Nuclear Technology and Engineering Center Low-Activity Waste Process Technology Program, FY-98 Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Herbst, A.K.; Rogers, A.Z.; McCray, J.A.; Simmons, R.F.; Palethorpe, S.J.

    1999-03-01

    The Low-Activity Waste Process Technology Program at the Idaho Nuclear Technology and Engineering Center (INTEC) anticipates that large volumes of low-level/low-activity wastes will need to be grouted prior to near-surface disposal. During fiscal year 1998, three grout formulations were studied for low-activity wastes derived from INTEC liquid sodium-bearing waste. Compressive strength and leach results are presented for phosphate bonding cement, acidic grout, and alkaline grout formulations. In an additional study, grout formulations are recommended for stabilization of the INTEC underground storage tank residual heels.

  2. Implementation of a metrology programme to provide traceability for radionuclides activity measurements in the CNEN Radiopharmaceuticals Producers Centers

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, Erica A.L. de; Braghirolli, Ana M.S.; Tauhata, Luiz; Gomes, Regio S.; Silva, Carlos J., E-mail: erica@ien.gov.br [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Delgado, Jose U.; Oliveira, Antonio E.; Iwahara, Akira, E-mail: ealima@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2013-07-01

    The commercialization and use of radiopharmaceuticals in Brazil are regulated by Agencia Nacional de Vigilancia Sanitaria (ANVISA) which require Good Manufacturing Practices (GMP) certification for Radiopharmaceuticals Producer Centers. Quality Assurance Program should implement the GMP standards to ensure radiopharmaceuticals have requirements quality to proving its efficiency. Several aspects should be controlled within the Quality Assurance Programs, and one of them is the traceability of the Radionuclides Activity Measurement in radiopharmaceuticals doses. The quality assurance of activity measurements is fundamental to maintain both the efficiency of the nuclear medicine procedures and patient and exposed occupationally individuals safety. The radiation doses received by patients, during the nuclear medicine procedures, is estimated according to administered radiopharmaceuticals quantity. Therefore it is very important either the activity measurements performed in radiopharmaceuticals producer centers (RPC) as the measurements performed in nuclear medicine services are traceable to national standards. This paper aims to present an implementation program to provide traceability to radionuclides activity measurements performed in the dose calibrators(well type ionization chambers) used in Radiopharmaceuticals Producer Center placed in different states in Brazil. The proposed program is based on the principles of GM Pand ISO 17025 standards. According to dose calibrator performance, the RPC will be able to provide consistent, safe and effective radioactivity measurement to the nuclear medicine services. (author)

  3. Implementation of a metrology programme to provide traceability for radionuclides activity measurements in the CNEN Radiopharmaceuticals Producers Centers

    International Nuclear Information System (INIS)

    The commercialization and use of radiopharmaceuticals in Brazil are regulated by Agencia Nacional de Vigilancia Sanitaria (ANVISA) which require Good Manufacturing Practices (GMP) certification for Radiopharmaceuticals Producer Centers. Quality Assurance Program should implement the GMP standards to ensure radiopharmaceuticals have requirements quality to proving its efficiency. Several aspects should be controlled within the Quality Assurance Programs, and one of them is the traceability of the Radionuclides Activity Measurement in radiopharmaceuticals doses. The quality assurance of activity measurements is fundamental to maintain both the efficiency of the nuclear medicine procedures and patient and exposed occupationally individuals safety. The radiation doses received by patients, during the nuclear medicine procedures, is estimated according to administered radiopharmaceuticals quantity. Therefore it is very important either the activity measurements performed in radiopharmaceuticals producer centers (RPC) as the measurements performed in nuclear medicine services are traceable to national standards. This paper aims to present an implementation program to provide traceability to radionuclides activity measurements performed in the dose calibrators(well type ionization chambers) used in Radiopharmaceuticals Producer Center placed in different states in Brazil. The proposed program is based on the principles of GM Pand ISO 17025 standards. According to dose calibrator performance, the RPC will be able to provide consistent, safe and effective radioactivity measurement to the nuclear medicine services. (author)

  4. 75 FR 22357 - Center for Nutrition Policy and Promotion; Agency Information Collection Activities; Current...

    Science.gov (United States)

    2010-04-28

    ... legislation that established the Department of Agriculture (USDA) (the Organic Act of 1862, 7 U.S.C. 2201... to: Jackie Haven, Director, Nutrition Marketing and Communications Division, Center for Nutrition... the Food, Nutrition and Consumer Services during regular business hours (8:30 a.m. to 5 p.m....

  5. REMOTE SENSING DEVELOPMENTS, RESEARCH AND ACTIVITIES AT THE ENVIRONMENTAL PHOTOGRAPHIC INTERPRETATION CENTER

    Science.gov (United States)

    The Environmental Photographic Interpretation Center (EPIC) has a 30+ year history of providing remote sensing support to EPA Regional and Program Offices. In addition to the its standard Technical Support mission, EPIC has developed a research program related to emerging technol...

  6. A Gender Comparison of the Cooperation of 4-Year-Old Children in Classroom Activity Centers

    Science.gov (United States)

    Anderson, Genan T.; Hilton, Sterling C.; Wouden-Miller, Melissa

    2003-01-01

    This study examined the proportion of cooperative play in 4-year-old children across centers (housekeeping, block, manipulative, and computer) and gender in a natural classroom setting. Eighty-four white, middle-income children (41 boys and 43 girls, mean age = 55 months) were videotaped during free-play for 30 minutes per day for four weeks in…

  7. Rationale for New York City’s Regulations on Nutrition, Physical Activity, and Screen Time in Early Child Care Centers

    OpenAIRE

    Nonas, Cathy; Silver, Lynn D; Kettel Khan, Laura; Leviton, Laura

    2014-01-01

    Childhood obesity is associated with health risks in childhood, and it increases the risk of adult obesity, which is associated with many chronic diseases. Therefore, implementing policies that may prevent obesity at young ages is important. In 2007, the New York City Department of Health and Mental Hygiene implemented new regulations for early childhood centers to increase physical activity, limit screen time, and provide healthful beverage offerings (ie, restrict sugar-sweetened beverages f...

  8. The International Science and Technology Center: Scope of activities and scientific projects in the field of nuclear data

    International Nuclear Information System (INIS)

    The review of the ISTC (The International Science and Technology Center) Programs and activities including Science Project Program, Partner Program, Seminar Program and others is presented. Project funding by technology area, by funding Parties, by CIS (Commonwealth of Independent States) States etc. is demonstrated with emphasis on projects in the field of nuclear data. The ISTC opportunities for international cooperation in the fields of nuclear data measurements, calculation, evaluation and dissemination are discussed. (author)

  9. Biilliards, rhythms, collectives - Billiards at a Danish activity center as a culturally specific form of active ageing

    DEFF Research Database (Denmark)

    Lassen, Aske Juul

    2014-01-01

    Through an ethnographic study of older men playing billiards at an activity centre and a document study of how the concept of activity has changed during the last 60 years, this article argues that active ageing policies overlook that activities are culturally significant forms of practise situated...

  10. Idaho Nuclear Technology and Engineering Center Low-Activity Waste Process Technology Program FY-99 Status Report

    International Nuclear Information System (INIS)

    The Low-Activity Waste Process Technology Program at the Idaho Nuclear Technology and Engineering Center (INTEC) anticipates that large volumes of low-level/low-activity wastes will need to be grouted prior to near-surface disposal. During fiscal year 1999, grout formulations were studied for transuranic waste derived from INTEC liquid sodium-bearing waste and for projected newly generated low-level liquid waste. Additional studies were completed on radionuclide leaching, microbial degradation, waste neutralization, and a small mockup for grouting the INTEC underground storage tank residual heels

  11. Idaho Nuclear Technology and Engineering Center Low-Activity Waste Process Technology Program FY-99 Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Herbst, Alan Keith; Mc Cray, John Alan; Kirkham, Robert John; Pao, Jenn Hai; Hinckley, Steve Harold

    1999-10-01

    The Low-Activity Waste Process Technology Program at the Idaho Nuclear Technology and Engineering Center (INTEC) anticipates that large volumes of low-level/low-activity wastes will need to be grouted prior to near-surface disposal. During fiscal year 1999, grout formulations were studied for transuranic waste derived from INTEC liquid sodium-bearing waste and for projected newly generated low-level liquid waste. Additional studies were completed on radionuclide leaching, microbial degradation, waste neutralization, and a small mockup for grouting the INTEC underground storage tank residual heels.

  12. Idaho Nuclear Technology and Engineering Center Low-Activity Waste Process Technology Program FY-99 Status Report

    Energy Technology Data Exchange (ETDEWEB)

    A. K. Herbst; J. A. McCray; R. J. Kirkham; J. Pao; S. H. Hinckley

    1999-09-30

    The Low-Activity Waste Process Technology Program at the Idaho Nuclear Technology and Engineering Center (INTEC) anticipates that large volumes of low-level/low-activity wastes will need to be grouted prior to near-surface disposal. During fiscal year 1999, grout formulations were studied for transuranic waste derived from INTEC liquid sodium-bearing waste and for projected newly generated low-level liquid waste. Additional studies were completed on radionuclide leaching, microbial degradation, waste neutralization, and a small mockup for grouting the INTEC underground storage tank residual heels.

  13. Nature of active centers and mechanism of olefin metathesis on applied oxide catalysts of molybdenum, tungsten and rhenium

    Energy Technology Data Exchange (ETDEWEB)

    Kadushin, A.A. (USSR Academy of Sciences); Aliyev, R.K.; Krylov, O.V.; Andreyev, A.A.; Yedreva-Kardzhiyeva, R.M.; Shopov, D.M.

    1982-03-01

    The authors undertook a systematic study of the effects of the carrier, activation conditions and the reaction itself on the formation and structure of active centers. Spectral characteristics of the systems studied were compared by infrared, ultraviolet, X-ray-electron and electron absorption spectroscopy, and X-ray-phase and chromatographic analyses. Catalytic activity in a metathesis reaction of propylene and butene-1 was tested in a quartz flow reactor at atmospheric pressure in a temperature range of 25-600/sup 0/C, with contact time of 3-50 seconds. The deposited oxide catalysts of the title minerals are discussed in terms of preparing the catalysts, studying their activity, and observing optical spectra. Tungsten ions were found to reduce at higher temperatures than molbydenum ions. Olefin treatment brought reduction of rhenium to lower oxidation levels. The low activities of Re/sub 2/O/sub 7//MgO at low temperatures is related to difficult electron transfer. The studies indicated the presence of a mobile center in the metathesis of olefins for oxide catalysis of all 3 title minerals, which is dependent on the chemical nature of the carrier and its crystalline structure.

  14. Probing the active center of benzaldehyde lyase with substitutions and the pseudosubstrate analogue benzoylphosphonic acid methyl ester.

    Science.gov (United States)

    Brandt, Gabriel S; Nemeria, Natalia; Chakraborty, Sumit; McLeish, Michael J; Yep, Alejandra; Kenyon, George L; Petsko, Gregory A; Jordan, Frank; Ringe, Dagmar

    2008-07-22

    Benzaldehyde lyase (BAL) catalyzes the reversible cleavage of ( R)-benzoin to benzaldehyde utilizing thiamin diphosphate and Mg (2+) as cofactors. The enzyme is important for the chemoenzymatic synthesis of a wide range of compounds via its carboligation reaction mechanism. In addition to its principal functions, BAL can slowly decarboxylate aromatic amino acids such as benzoylformic acid. It is also intriguing mechanistically due to the paucity of acid-base residues at the active center that can participate in proton transfer steps thought to be necessary for these types of reactions. Here methyl benzoylphosphonate, an excellent electrostatic analogue of benzoylformic acid, is used to probe the mechanism of benzaldehyde lyase. The structure of benzaldehyde lyase in its covalent complex with methyl benzoylphosphonate was determined to 2.49 A (Protein Data Bank entry 3D7K ) and represents the first structure of this enzyme with a compound bound in the active site. No large structural reorganization was detected compared to the complex of the enzyme with thiamin diphosphate. The configuration of the predecarboxylation thiamin-bound intermediate was clarified by the structure. Both spectroscopic and X-ray structural studies are consistent with inhibition resulting from the binding of MBP to the thiamin diphosphate in the active centers. We also delineated the role of His29 (the sole potential acid-base catalyst in the active site other than the highly conserved Glu50) and Trp163 in cofactor activation and catalysis by benzaldehyde lyase.

  15. Quality-Assurance Plan for Water-Quality Activities in the U.S. Geological Survey Washington Water Science Center

    Science.gov (United States)

    Wagner, Richard J.; Kimbrough, Robert A.; Turney, Gary L.

    2007-01-01

    In accordance with guidelines set forth by the Office of Water Quality in the Water Resources Discipline of the U.S. Geological Survey (USGS), this quality-assurance plan has been created for use by the USGS Washington Water Science Center (WAWSC) in conducting water-quality activities. The plan documents the standards, policies, and procedures used by the personnel of the WAWSC for activities related to the collection, processing, storage, analysis, and publication of water-quality data. The policies and procedures that are documented in this quality-assurance plan for water-quality activities are meant to complement the WAWSC's quality-assurance plans for surface-water and ground-water activities and to supplement the WAWSC quality-assurance plan.

  16. The Center of Our Galaxy Activity and High-Energy Emission of the Closest Massive Black Hole

    CERN Document Server

    Goldwurm, A

    2001-01-01

    The Center of our Galaxy is a peculiar region where a number of crucial astrophysical phenomena take place, from star formation to SN explosions and accretion onto a massive black hole. The quest for a massive black hole in the Galactic Nucleus is of course of particular relevance because, it would be the closest of such extreme objects, which are now believed to reside in most of the galactic nuclei of the universe. I will review here the main observational characteristics of the Galactic Center with particular attention to the the problem of existence, physical condition and activity of the 3 10E6 Mo black hole coincident with the compact radio source Sgr A*. I will report historical and recent results of high energy observations of the central degree of our Galaxy, along with the specific accretion models proposed to account for the apparent lack of high energy activity from Sgr A*. The scientific perspectives of the next X and gamma-ray missions in the domain of the Galactic Center physics are also mentio...

  17. Vertical flows and structures excited by magnetic activity in the Galactic center region

    CERN Document Server

    Kakiuchi, Kensuke; Fukui, Yasuo; Torii, Kazufumi; Machida, Mami; Matsumoto, Ryoji

    2016-01-01

    The vertical flow structure in the galactic center region remains poorly understood. We analyzed the MHD simulation data by Suzuki et al. (2015) for better understanding. As a result, we found the fast downflows with a speed of ~100 km/s near the foot-points of magnetic loops. These downflows are flowing along a magnetic field line and accelerated by the gravity. The direction of the fast flows is changed by the magnetic loop geometry, as it moves. As a result, not only vertical motions but also azimuthal and radial motions are excited. This feature could be relevant to the observed high velocity dispersion in the position-velocity diagram.

  18. Nuclear Thermal Propulsion (NTP) Development Activities at the NASA Marshall Space Flight Center - 2006 Accomplishments

    Science.gov (United States)

    Ballard, Richard O.

    2007-01-01

    In 2005-06, the Prometheus program funded a number of tasks at the NASA-Marshall Space Flight Center (MSFC) to support development of a Nuclear Thermal Propulsion (NTP) system for future manned exploration missions. These tasks include the following: 1. NTP Design Develop Test & Evaluate (DDT&E) Planning 2. NTP Mission & Systems Analysis / Stage Concepts & Engine Requirements 3. NTP Engine System Trade Space Analysis and Studies 4. NTP Engine Ground Test Facility Assessment 5. Non-Nuclear Environmental Simulator (NTREES) 6. Non-Nuclear Materials Fabrication & Evaluation 7. Multi-Physics TCA Modeling. This presentation is a overview of these tasks and their accomplishments

  19. Integrative Student Learning: An Effective Team Learning Activity in a Learner-Centered Paradigm

    OpenAIRE

    Reza Karimi, RPh, PhD; Fawzy Elbarbry, PhD; Jeff Fortner, PharmD

    2011-01-01

    Purpose: An Integrative Student Learning (ISL) activity was developed with the intent to enhance the dynamic of student teamwork and enhance student learning by fostering critical-thinking skills, self-directed learning skills, and active learning. Case Study: The ISL activity consists of three portions: teambuilding, teamwork, and a facilitator driven “closing the loop” feedback discussion. For teambuilding, a set of clue sheets or manufacturer‘s drug containers were distributed among studen...

  20. Active Living: development and quasi-experimental evaluation of a school-centered physical activity intervention for primary school children

    NARCIS (Netherlands)

    Kann, D.H.H. van; Jansen, M.W.J.; Vries, S.I. de; Vries, N.K. de; Kremers, S.P.J.

    2015-01-01

    Background The worldwide increase in the rates of childhood overweight and physical inactivity requires successful prevention and intervention programs for children. The aim of the Active Living project is to increase physical activity and decrease sedentary behavior of Dutch primary school children

  1. Integrative Student Learning: An Effective Team Learning Activity in a Learner-Centered Paradigm

    Directory of Open Access Journals (Sweden)

    Reza Karimi, RPh, PhD

    2011-01-01

    Full Text Available Purpose: An Integrative Student Learning (ISL activity was developed with the intent to enhance the dynamic of student teamwork and enhance student learning by fostering critical-thinking skills, self-directed learning skills, and active learning. Case Study: The ISL activity consists of three portions: teambuilding, teamwork, and a facilitator driven “closing the loop” feedback discussion. For teambuilding, a set of clue sheets or manufacturer‘s drug containers were distributed among student pairs who applied their pharmaceutical knowledge to identify two more student pairs with similar clues or drugs, thus building a team of six. For teamwork, each team completed online exams, composed of integrated pharmaceutical science questions with clinical correlates, using only selected online library resources. For the feedback discussion, facilitators evaluated student impressions, opened a discussion about the ISL activity, and provided feedback to teams’ impressions and questions. This study describes three different ISL activities developed and implemented over three days with first year pharmacy students. Facilitators’ interactions with students and three surveys indicated a majority of students preferred ISL over traditional team activities and over 90% agreed ISL activities promoted active learning, critical-thinking, self-directed learning, teamwork, and student confidence in online library searches. Conclusions: The ISL activity has proven to be an effective learning activity that promotes teamwork and integration of didactic pharmaceutical sciences to enhance student learning of didactic materials and confidence in searching online library resources. It was found that all of this can be accomplished in a short amount of class time with a very reasonable amount of preparation.

  2. Designing a knowledge management system for distributed activities: a human centered approach.

    Science.gov (United States)

    Rinkus, Susan; Johnson-Throop, Kathy A; Zhang, Jiajie

    2003-01-01

    In this study we use the principles of distributed cognition and the methodology of human-centered distributed information design to analyze a complex distributed human-computer system, identify its problems, and generate design requirements and implementation specifications of a replacement prototype for effective organizational memory and knowledge management. We argue that a distributed human-computer information system has unique properties, structures and processes that are best described in the language of distributed cognition. Distributed cognition provides researchers a richer theoretical understanding of human-computer interactions and enables re-searchers to capture the phenomenon that emerges in social interactions as well as the interactions between people and structures in their environment.

  3. Accelerating Energy Efficiency in Indian Data Centers. Final Report for Phase I Activities

    Energy Technology Data Exchange (ETDEWEB)

    Ganguly, Suprotim [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Raje, Sanyukta [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Kumar, Satish [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sartor, Dale [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Greenberg, Steve [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2016-01-01

    This report documents Phase 1 of the “Accelerating Energy Efficiency in Indian Data Centers” initiative to support the development of an energy efficiency policy framework for Indian data centers. The initiative is being led by the Confederation of Indian Industry (CII), in collaboration with Lawrence Berkeley National Laboratory (LBNL)-U.S. Department of Energy’s Office of Energy Efficiency and Renewable Energy, and under the guidance of Bureau of Energy Efficiency (BEE). It is also part of the larger Power and Energy Efficiency Working Group of the US-India Bilateral Energy Dialogue. The initiative consists of two phases: Phase 1 (November 2014 – September 2015) and Phase 2 (October 2015 – September 2016).

  4. RECENT ACTIVITIES AT THE CENTER FOR SPACE NUCLEAR RESEARCH FOR DEVELOPING NUCLEAR THERMAL ROCKETS

    Energy Technology Data Exchange (ETDEWEB)

    Robert C. O' Brien

    2001-09-01

    Nuclear power has been considered for space applications since the 1960s. Between 1955 and 1972 the US built and tested over twenty nuclear reactors/ rocket-engines in the Rover/NERVA programs. However, changes in environmental laws may make the redevelopment of the nuclear rocket more difficult. Recent advances in fuel fabrication and testing options indicate that a nuclear rocket with a fuel form significantly different from NERVA may be needed to ensure public support. The Center for Space Nuclear Research (CSNR) is pursuing development of tungsten based fuels for use in a NTR, for a surface power reactor, and to encapsulate radioisotope power sources. The CSNR Summer Fellows program has investigated the feasibility of several missions enabled by the NTR. The potential mission benefits of a nuclear rocket, historical achievements of the previous programs, and recent investigations into alternatives in design and materials for future systems will be discussed.

  5. Atominform's activities as the information and analytical center of nuclear industry and power of Russia

    International Nuclear Information System (INIS)

    The Central Research Institute of Management, Economics and Information, Atominform, is a division of information-analytical support of scientific, production and commercial efforts of the nuclear industry and is also involved in the most ''traditional'' information activity. These ''traditional'' lines of activity include: compilation and maintenance of all types of data bases and their reference facilities; library activities; information support; information flows both between the nuclear industry enterprises and through exchange with information bodies of the state system of scientific and technical information and other branches of the national economy; introduction of the state-of-the-art information technologies into the information practice. (orig.)

  6. Direct observation of the active center for methane dehydroaromatization using an ultrahigh field 95Mo NMR spectroscopy.

    Science.gov (United States)

    Zheng, Heng; Ma, Ding; Bao, Xinhe; Hu, Jian Zhi; Kwak, Ja Hun; Wang, Yong; Peden, Charles H F

    2008-03-26

    The use of an ultrahigh magnetic field spectrometer and 95Mo isotope enrichment facilitate the direct observation of the local structure of Mo species on Mo/zeolite catalysts by 95Mo NMR. Top trace: The experimental 95Mo NMR spectrum of 6Mo/HZSM-5. Bottom traces: The simulated overall spectrum (orange), the spectral component corresponding to MoO3 (purple), and the component corresponding to the exchanged Mo species (green). The exchanged Mo species proved to be the active center for the methane dehydroaromatization (MDA) reaction.

  7. Senior Centers

    Medline Plus

    Full Text Available ... dancing. [Narrator] These centers can provide entree to new activities and expand a person’s social contacts. [Karen ... meeting all their interests and introducing them to new things; whether it’s an arts and crafts project, ...

  8. Validation of Using Fitness Center Attendance Electronic Records to Assess the Frequency of Moderate/Vigorous Leisure-Time Physical Activity among Adults

    Science.gov (United States)

    Amireault, Steve; Godin, Gaston

    2014-01-01

    The purpose of this study was to provide three construct validity evidence for using fitness center attendance electronic records to objectively assess the frequency of leisure-time physical activity among adults. One hundred members of a fitness center (45 women and 55 men; aged 18 to 64 years) completed a self-report leisure-time physical…

  9. A dicopper complex with distant metal centers. Structure, magnetic properties, electrochemistry and catecholase activity.

    Science.gov (United States)

    Gasque, Laura; Ugalde-Saldívar, Víctor Manuel; Membrillo, Ingrid; Olguín, Juan; Mijangos, Edgar; Bernès, Sylvain; González, Ignacio

    2008-01-01

    The crystal structure and magnetic properties of a dinuclear copper(II) complex of the ligand [2,8-dimethyl-5,11-di-(dimethylethyleneamine) 1,4,5,6,7,10,11,12-octahydroimidazo [4,5-h] imidazo [4,5-c] [1,6]diazecine] dimeim have been investigated. Also, its catecholase activity has been explored in different solvent mixtures: MeCN/H2O and OH/H2O, each at several pH values. In CH3OH/H2O, where the activity was superior, the optimal pH value for the catalytic activity was found to be lower than in CH3CN/H2O. The study of the complex's electrochemical behavior (cyclic voltammetry) which was also investigated in these various media, revealed that although an increase in pH in both solvent mixtures results in an increase both in Me oxidizing power (E(1/2)) and reversibility (ipa/ipc) the change of solvent system seems to be a more influencing factor. The superior catalytic activity found in MeOH/H2O pH=8.0, is associated with a significantly more reversible behavior displayed in this medium. Potentiometric determination of the overall formation constant and three successive pKas for the complex, suggest the formation of stable hydroxo complexes which could be the catalytically active species.

  10. A New Perspective of the Radio Bright Zone at The Galactic Center: Feedback from Nuclear Activities

    CERN Document Server

    Zhao, Jun-Hui; Goss, W M

    2015-01-01

    New observations of Sgr A have been carried out with the VLA using the broadband (2 GHz) continuum mode at 5.5 GHz, covering the central 30 pc region of the RBZ at the Galactic center. Using the MS-MFS algorithms in CASA, we have imaged Sgr A with a resolution of 1", achieving an rms 8 $\\mu$Jy/beam, and a dynamic range 100,000:1.The radio image is compared with X-ray, CN emission-line and Paschen-$\\alpha$ images obtained using Chandra, SMA and HST/NICMOS, respectively. We discuss several prominent radio features. The "Sgr A West Wings" extend 5 pc from the NW and SE tips of the ionized "Mini-spiral" in Sgr A West to positions located 2.9 and 2.4 arc min to the NW and SE of Sgr A*, respectively. The NW wing, along with several other prominent features, including the "NW Streamers", form an elongated radio lobe (NW lobe), oriented nearly perpendicular to the Galactic plane. This radio lobe, with a size of 14.4 pc x 7.3 pc, has a known X-ray counterpart. A row of three thermally emitting rings is observed in the...

  11. Diffuse gamma-ray emission from the Galactic center and implications of its past activities

    CERN Document Server

    Fujita, Yutaka; Murase, Kohta

    2016-01-01

    It has been indicated that low-luminosity active galactic nuclei (LLAGNs) are accelerating high-energy cosmic-ray (CR) protons in their radiatively inefficient accretion flows (RIAFs). If this is the case, Sagittarius A* (Sgr A*) should also be generating CR protons, because Sgr A* is a LLAGN. Based on this scenario, we calculate a production rate of CR protons in Sgr A* and their diffusion in the central molecular zone (CMZ) around Sgr A*. The CR protons diffusing in the CMZ create gamma-rays through pp interaction. We show that the gamma-ray luminosity and spectrum are consistent with observations if Sgr A* was active in the past.

  12. Conceptualizing a Theoretical Model for School-Centered Adolescent Physical Activity Intervention Research

    Science.gov (United States)

    Chen, Ang; Hancock, Gregory R.

    2006-01-01

    Adolescent physical inactivity has risen to an alarming rate. Several theoretical frameworks (models) have been proposed and tested in school-based interventions. The results are mixed, indicating a similar weakness as that observed in community-based physical activity interventions (Baranowski, Lin, Wetter, Resnicow, & Hearn, 1997). The…

  13. Direct Observation of the Active Center for Methane Dehydroaromatization Using an Ultrahigh Field 95Mo NMR Spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, Heng; Ma, Ding; Bao, Xinhe; Hu, Jian Zhi; Kwak, Ja Hun; Wang, Yong; Peden, Charles HF

    2008-03-26

    Direct conversion of methane to value-added chemicals remains a challenge from both scientific and industrial points of view. In 1993, Wang et al. reported that methane can be transformed into aromatics on Mo/HZSM-5 catalysts under non-oxidative condition.1 Although remarkable progress has been made in the studies of the methane dehydroaromatization (MDA) reaction since that time, the reaction mechanism is still being debated,2 mainly due to the lack of understanding of the active center on Mo/HZSM-5 catalysts.3 It has been hypothesized that molybdenum may migrate into zeolitic channels and anchor on Brönsted acid sites during the synthesis. However, it is unclear whether the active molybdenum species are small crystallites or isolated exchanged species.

  14. Epiphyseal chondrocyte secondary ossification centers require thyroid hormone activation of Indian hedgehog and osterix signaling.

    Science.gov (United States)

    Xing, Weirong; Cheng, Shaohong; Wergedal, Jon; Mohan, Subburaman

    2014-10-01

    Thyroid hormones (THs) are known to regulate endochondral ossification during skeletal development via acting directly in chondrocytes and osteoblasts. In this study, we focused on TH effects on the secondary ossification center (SOC) because the time of appearance of SOCs in several species coincides with the time when peak levels of TH are attained. Accordingly, micro-computed tomography (µCT) evaluation of femurs and tibias at day 21 in TH-deficient and control mice revealed that endochondral ossification of SOCs is severely compromised owing to TH deficiency and that TH treatment for 10 days completely rescued this phenotype. Staining of cartilage and bone in the epiphysis revealed that whereas all of the cartilage is converted into bone in the prepubertal control mice, this conversion failed to occur in the TH-deficient mice. Immunohistochemistry studies revealed that TH treatment of thyroid stimulating hormone receptor mutant (Tshr(-/-) ) mice induced expression of Indian hedgehog (Ihh) and Osx in type 2 collagen (Col2)-expressing chondrocytes in the SOC at day 7, which subsequently differentiate into type 10 collagen (Col10)/osteocalcin-expressing chondro/osteoblasts at day 10. Consistent with these data, treatment of tibia cultures from 3-day-old mice with 10 ng/mL TH increased expression of Osx, Col10, alkaline phosphatase (ALP), and osteocalcin in the epiphysis by sixfold to 60-fold. Furthermore, knockdown of the TH-induced increase in Osx expression using lentiviral small hairpin RNA (shRNA) significantly blocked TH-induced ALP and osteocalcin expression in chondrocytes. Treatment of chondrogenic cells with an Ihh inhibitor abolished chondro/osteoblast differentiation and SOC formation. Our findings indicate that TH regulates the SOC initiation and progression via differentiating chondrocytes into bone matrix-producing osteoblasts by stimulating Ihh and Osx expression in chondrocytes. PMID:24753031

  15. Education of natural science in the work of the Municipal Center for Extracurricular Activities

    Science.gov (United States)

    Jokin, I.

    2012-04-01

    In the description of my work I presented my own experience in the organizing and carrying out of extracurricular activities with the students, the used modes and methods of work, the obtained results and some good practices in the field of natural sciences. Organizing and carrying out of scientific festivals, participation in joint projects together with scientific organizations. Key words: European dimension, interactive methods, key competences, natural sciences, extracurricular activities. We are witnesses of a fundamental change in the pedagogical culture and practice in our schools to establish the parameters of the quality of training. The good scientific culture is an important part of the students' education. Unfortunately, at the present time the scientific and technological culture is on a low level. One of the contemporary problems and realities of the education in natural science school subjects, as a whole and in particular in the secondary education, is the decreased interest for the training in them and in particular in physics, as well as synchronization of the interrelations: school environment - society. In many countries there is a drop in the orientation of the students towards the science and technology - the problem of Science and Technology (S&T). The training of the young people often creates some problems. The teachers meet with the problem of insufficient motivation of the learners for study and difficulties that they encounter in the process of training. The students find it difficult to apply the mastered knowledge to an applied context. The knowledge is rather academic and rather remote from the context, in which the children live and communicate, which makes it nonfunctional. At present there are not enough extracurricular activities that should meet these necessities of the Bulgarian school. The reasons are various, but they mainly consist in the lack of a material base, an exchange of experience and good practices and motivation

  16. Activity-based costing via an information system: an application created for a breast imaging center

    OpenAIRE

    Hawkins, Hugh; Langer, Jennifer; Padua, Eric; Reaves, Jason

    2001-01-01

    Activity-based costing (ABC) is a process that enables the estimation of the cost of producing a product or service. More accurate than traditional charge-based approaches, it emphasizes analysis of processes, and more specific identification of both direct and indirect costs. This accuracy is essential in today’s healthcare environment, in which managed care organizations necessitate responsible and accountable costing. However, to be successfully utilized, it requires time, effort, expertis...

  17. A research program in active control/aeroelasticity in the JIAFS at NASA Langley Research Center

    Science.gov (United States)

    Whitesides, J. L.

    1984-01-01

    A control law synthesis methodology for multifunctional active control system to satisfy root-mean-square load and response constraints as well as to meet stability robustness requirements at plant input and output was developed. Modern control theory, singular value analysis and optimization techniques were utilized. All stability and response derivative expressions were derived analytically for sensitivity study. The software is incorporated as an update to the AB/LAD general control design software package PADLOCS.

  18. A brief overview of computational structures technology related activities at NASA Lewis Research Center

    Science.gov (United States)

    Hopkins, Dale A.

    1992-01-01

    The presentation gives a partial overview of research and development underway in the Structures Division of LeRC, which collectively is referred to as the Computational Structures Technology Program. The activities in the program are diverse and encompass four major categories: (1) composite materials and structures; (2) probabilistic analysis and reliability; (3) design optimization and expert systems; and (4) computational methods and simulation. The approach of the program is comprehensive and entails exploration of fundamental theories of structural mechanics to accurately represent the complex physics governing engine structural performance, formulation, and implementation of computational techniques and integrated simulation strategies to provide accurate and efficient solutions of the governing theoretical models by exploiting the emerging advances in computer technology, and validation and verification through numerical and experimental tests to establish confidence and define the qualities and limitations of the resulting theoretical models and computational solutions. The program comprises both in-house and sponsored research activities. The remainder of the presentation provides a sample of activities to illustrate the breadth and depth of the program and to demonstrate the accomplishments and benefits that have resulted.

  19. Taking a Stand as a Student-Centered Research University: Active and Collaborative Learning Meets Scholarship of Teaching at the University of Alabama

    Science.gov (United States)

    Bonner, Judy

    2010-01-01

    This article introduces the University of Alabama, outlines efforts in the scholarship of teaching and active and collaborative learning, and describes plans for continuing the instructional focus as a student-centered research university, where teaching is viewed as a scholarly activity and students are actively engaged in their learning.

  20. Structure and catalytic activities of ferrous centers confined on the interface between carbon nanotubes and humic acid

    Science.gov (United States)

    Wang, Bing; Zhou, Xiaoyan; Wang, Dongqi; Yin, Jun-Jie; Chen, Hanqing; Gao, Xingfa; Zhang, Jing; Ibrahim, Kurash; Chai, Zhifang; Feng, Weiyue; Zhao, Yuliang

    2015-01-01

    Preparation of heterogeneous catalysts with active ferrous centers is of great significance for industrial and environmental catalytic processes. Nanostructured carbon materials (NCM), which possess free-flowing π electrons, can coordinate with transition metals, provide a confinement environment for catalysis, and act as potential supports or ligands to construct analogous complexes. However, designing such catalysts using NCM is still seldom studied to date. Herein, we synthesized a sandwich structured ternary complex via the coordination of Fe-loaded humic acid (HA) with C&z.dbd;C bonds in the aromatic rings of carbon nanotubes (CNTs), in which the O/N-Fe-C interface configuration provides the confinement environment for the ferrous sites. The experimental and theoretical results revealed octahedrally/tetrahedrally coordinated geometry at Fe centers, and the strong hybridization between CNT C π* and Fe 3d orbitals induces discretization of the atomic charges on aromatic rings of CNTs, which facilitates O2 adsorption and electron transfer from carbon to O2, which enhances O2 activation. The O2 activation by the novel HA/Fe-CNT complex can be applied in the oxidative degradation of phenol red (PR) and bisphenol A (BPA) in aqueous media.Preparation of heterogeneous catalysts with active ferrous centers is of great significance for industrial and environmental catalytic processes. Nanostructured carbon materials (NCM), which possess free-flowing π electrons, can coordinate with transition metals, provide a confinement environment for catalysis, and act as potential supports or ligands to construct analogous complexes. However, designing such catalysts using NCM is still seldom studied to date. Herein, we synthesized a sandwich structured ternary complex via the coordination of Fe-loaded humic acid (HA) with C&z.dbd;C bonds in the aromatic rings of carbon nanotubes (CNTs), in which the O/N-Fe-C interface configuration provides the confinement environment for the

  1. A New Perspective of the Radio Bright Zone at The Galactic Center: Feedback from Nuclear Activities

    Science.gov (United States)

    Zhao, Jun-Hui; Morris, Mark R.; Goss, W. M.

    2016-02-01

    New observations of Sgr A have been carried out with the Jansky VLA in the B and C arrays using the broadband (2 GHz) continuum mode at 5.5 GHz. The field of view covers the central 13‧ (30 pc) region of the radio-bright zone at the Galactic center. Using the multi-scale and multi-frequency-synthesis (MS-MFS) algorithms in CASA, we have imaged Sgr A with a resolution of 1″, achieving an rms noise of 8 μJy beam-1, and a dynamic range of 100,000:1. Both previously known and newly identified radio features in this region are revealed, including numerous filamentary sources. The radio continuum image is compared with Chandra X-ray images, with a CN emission-line image obtained with the Submillimeter Array and with detailed Paschen-α images obtained with Hubble Space Telescope/NICMOS. We discuss several prominent features in the radio image. The “Sgr A west Wings” extend 2‧ (5 pc) from the NW and SE tips of the Sgr A west H ii region (the “Mini-spiral”) to positions located 2.9 and 2.4 arcmin to the northwest and southeast of Sgr A*, respectively. The NW wing, along with several other prominent features, including the previously identified “NW Streamers,” form an elongated radio lobe (NW lobe), oriented nearly perpendicular to the Galactic plane. This radio lobe, with a size of 6.‧3 × 3.‧2 (14.4 pc × 7.3 pc), has a known X-ray counterpart. In the outer region of the NW lobe, a row of three thermally emitting rings is observed. A field containing numerous amorphous radio blobs extends for a distance of ˜2 arcmin beyond the tip of the SE wing; these newly recognized features coincide with the SE X-ray lobe. Most of the amorphous radio blobs in the NW and SE lobes have Paschen-α counterparts. We propose that they have been produced by shock interaction of ambient gas concentrations with a collimated nuclear wind or an outflow that originated from within the circumnuclear disk (CND). We also discuss the possibility that the ionized wind or

  2. The German Brown Boveri, a center of the company's nuclear activities

    International Nuclear Information System (INIS)

    The main activity of the German Brown Boveri Comp. is the pebble-bed reactor system. The experimental power unit AVR-15 went into operation in 1967 and has been demonstrating for the last 20 years the excellent behaviour of a helium-cooled pebble-bed reactor (15 MWe). The 300 MWe Thorium High Temperature Reactor (THTR-300) has been in full operation since September 1986. The follow-up projects HTR-500 (550 MWe) and HTR-100 (100 MWe) are under development. The Gas-Cooled Heating Reactor of 10 MW thermal power (GHR-10th) is under evaluation in Switzerland together with two other concepts of small heating reactors. LWR systems were also taken up by Brown Boveri in the mid sixties when BBC, as an experienced supplier of turbine generators and electrical and control equipment, formed partnerships with experienced reactor suppliers for example, Westinghouse and General Electric, to deliver turnkey nuclear power plants

  3. DNA damage-centered signaling pathways are effectively activated during low dose-rate Auger radioimmunotherapy

    International Nuclear Information System (INIS)

    Introduction: Low dose-rate radioimmunotherapy (RIT) using 125I-labelled monoclonal antibodies (125I-mAbs) is associated with unexpected high cytotoxicity per Gy. Methods: We investigated whether this hypersensitivity was due to lack of detection of DNA damage by the targeted cells. DNA damage was measured with the alkaline comet assay, gamma-H2AX foci and the micronucleus test in p53−/− and p53+/+ HCT116 cells exposed to increasing activities of internalizing anti-HER1 125I-mAbs or non-internalizing anti-CEA 125I-mAbs. The expression of proteins involved in radiation response and progression of cells through the cycle were determined. Results: Cell hypersensitivity to low absorbed doses of anti-CEA 125I-mAbs was not due to defect in DNA damage detection, since ATM (ataxia telangiectasia mutated gene), gamma-H2AX, p53 and p21 were activated in RIT-treated HCT116 cells and G2/M cell cycle arrest was observed. Moreover, the alkaline comet assay showed that DNA breaks accumulated when cells were placed at 4 °C during exposure but were repaired under standard RIT conditions (37 °C), suggesting that lesions detected under alkaline conditions (mostly DNA single strand breaks and alkali-labile sites) are efficiently repaired in treated cells. The level of gamma-H2AX protein corroborated by the level of foci measured in nuclei of treated cells was shown to accumulate with time thereby suggesting the continuous presence of DNA double strand breaks. This was accompanied by the formation of micronuclei. Conclusion: Hypersensitivity to non-internalizing 125I-mAbs is not due to lack of detection of DNA damage after low absorbed dose-rates. However, DNA double strand breaks accumulate in cells exposed both to internalizing and non-internalizing 125I-mAbs and lead to micronuclei formation. These results suggest impairment in DNA double strand breaks repair after low absorbed doses of 125I-mAbs

  4. Luminescence induced by dehydration of kaolin - Association with electron-spin-active centers and with surface activity for dehydration-polymerization of glycine

    Science.gov (United States)

    Coyne, L.; Hovatter, W.; Sweeney, M.

    1983-01-01

    Experimental data concerning emission of light upon dehydration as a function of preheating and pre-gamma-irradiation are correlated with reported studies of electron-spin resonance (ESR) activity after similar pretreatments. The effect of these pretreatments on the kaolin-promoted incorporation of glycine into peptide oligomers in a wet/cold, hot/dry fluctuating environment is compared to their effect on the ESR and luminescent signals. The existence of spectroscopically active centers appears to be loosely anticorrelated with reaction yield; these yields are increased by increasing the overall energy content of the material. It is concluded that some part of the chemical yield is produced by a mechanism involving intrinsic, excited electronic states of the clay crystal lattice. These states may be derived from thermally, interfacially, and/or mechanically induced charge reorganization within interspersed energy levels in the band structure of the material.

  5. Tornadoes: A Center Approach.

    Science.gov (United States)

    Christman-Rothlein, Liz; Meinbach, Anita M.

    1981-01-01

    Information is given on how to put together a learning center. Discusses information and activity packets for a complete learning center on tornadoes including objectives, directions, materials, photographs of physical arrangements, and posttest. (DC)

  6. BKG Data Center

    Science.gov (United States)

    Thorandt, Volkmar; Wojdziak, Reiner

    2013-01-01

    This report summarizes the activities and background information of the IVS Data Center for the year 2012. Included is information about functions, structure, technical equipment, and staff members of the BKG Data Center.

  7. Activity based costing of diagnostic procedures at a nuclear medicine center of a tertiary care hospital

    International Nuclear Information System (INIS)

    Escalating health care expenses pose a new challenge to the health care environment of becoming more cost-effective. There is an urgent need for more accurate data on the costs of health care procedures. Demographic changes, changing morbidity profile, and the rising impact of noncommunicable diseases are emphasizing the role of nuclear medicine (NM) in the future health care environment. However, the impact of emerging disease load and stagnant resource availability needs to be balanced by a strategic drive towards optimal utilization of available healthcare resources. The aim was to ascertain the cost of diagnostic procedures conducted at the NM Department of a tertiary health care facility by employing activity based costing (ABC) method. A descriptive cross-sectional study was carried out over a period of 1 year. ABC methodology was utilized for ascertaining unit cost of different diagnostic procedures and such costs were compared with prevalent market rates for estimating cost effectiveness of the department being studied. The cost per unit procedure for various procedures varied from Rs. 869 (USD 14.48) for a thyroid scan to Rs. 11230 (USD 187.16) for a meta-iodo-benzyl-guanidine (MIBG) scan, the most cost-effective investigations being the stress thallium, technetium-99 m myocardial perfusion imaging (MPI) and MIBG scan. The costs obtained from this study were observed to be competitive when compared to prevalent market rates. ABC methodology provides precise costing inputs and should be used for all future costing studies in NM Departments

  8. Hypothetical biotechnology companies: A role-playing student centered activity for undergraduate science students.

    Science.gov (United States)

    Chuck, Jo-Anne

    2011-01-01

    Science students leaving undergraduate programs are entering the biotechnology industry where they are presented with issues which require integration of science content. Students find this difficult as through-out their studies, most content is limited to a single subdiscipline (e.g., biochemistry, immunology). In addition, students need knowledge of the ethical, economic, and legal frame work in which the industry operates. This article presents an approach to deliver these outcomes in a collaborative and active learning modality which promotes deep learning. In the model, groups of final year undergraduate students form hypothetical biotechnology companies and identify real issues of interest to industry, make integrative team decisions, use professional level technology, and develop appropriate communication skills. The final successful teaching paradigm was based on self reflection, observation, and student feedback to ensure appropriate attainment of content, group work skills and increased confidence in professional decision-making. It is these outcomes which will facilitate life long learning skills, a major outcome applicable for all tertiary education.

  9. (BB)-Carboryne Complex of Ruthenium: Synthesis by Double B-H Activation at a Single Metal Center.

    Science.gov (United States)

    Eleazer, Bennett J; Smith, Mark D; Popov, Alexey A; Peryshkov, Dmitry V

    2016-08-24

    The first example of a transition metal (BB)-carboryne complex containing two boron atoms of the icosahedral cage connected to a single exohedral metal center (POBBOP)Ru(CO)2 (POBBOP = 1,7-OP(i-Pr)2-2,6-dehydro-m-carborane) was synthesized by double B-H activation within the strained m-carboranyl pincer framework. Theoretical calculations revealed that the unique three-membered (BB)>Ru metalacycle is formed by two bent B-Ru σ-bonds with the concomitant increase of the bond order between the two metalated boron atoms. The reactivity of the highly strained electron-rich (BB)-carboryne fragment with small molecules was probed by reactions with electrophiles. The carboryne-carboranyl transformations reported herein represent a new mode of cooperative metal-ligand reactivity of boron-based complexes. PMID:27526855

  10. Modeling crustal deformation near active faults and volcanic centers: a catalog of deformation models and modeling approaches

    Science.gov (United States)

    Battaglia, Maurizio; ,; Peter, F.; Murray, Jessica R.

    2013-01-01

    This manual provides the physical and mathematical concepts for selected models used to interpret deformation measurements near active faults and volcanic centers. The emphasis is on analytical models of deformation that can be compared with data from the Global Positioning System (GPS) receivers, Interferometric synthetic aperture radar (InSAR), leveling surveys, tiltmeters and strainmeters. Source models include pressurized spherical, ellipsoidal, and horizontal penny-shaped geometries in an elastic, homogeneous, flat half-space. Vertical dikes and faults are described following the mathematical notation for rectangular dislocations in an elastic, homogeneous, flat half-space. All the analytical expressions were verified against numerical models developed by use of COMSOL Multyphics, a Finite Element Analysis software (http://www.comsol.com). In this way, typographical errors present were identified and corrected. Matlab scripts are also provided to facilitate the application of these models.

  11. Environmental systems and management activities on the Kennedy Space Center, Merritt Island, Florida: results of a modeling workshop

    Science.gov (United States)

    Hamilton, David B.; Andrews, Austin K.; Auble, Gregor T.; Ellison, Richard A.; Farmer, Adrian H.; Roelle, James E.

    1985-01-01

    In the early 1960's, the National Aeronautics and Space Administration (NASA) began purchasing 140,000 acres on Merritt Island, Florida, in order to develop a center for space exploration. Most of this land was acquired to provide a safety and security buffer around NASA facilities. NASA, as the managing agency for the Kennedy Space Center (KSC), is responsible for preventing or controlling environmental pollution from the Federal facilities and activities at the Space Center and is committed to use all practicable means to protect and enhance the quality of the surrounding environment. The Merritt Island National Wildlife Refuge was established in 1963 when management authority for undeveloped lands at KSC was transferred to the U.S. Fish and Wildlife Service. In addition to manage for 11 Federally-listed threatened and endangered species and other resident and migratory fish and wildlife populations, the Refuge has comanagement responsibility for 19,000 acres of mosquito control impoundments and 2,500 acres of citrus groves. The Canaveral National Seashore was developed in 1975 when management of a portion of the coastal lands was transferred from NASA to the National Park Service. This multiagency jurisdiction on Merritt Island has resulted in a complex management environment. The modeling workshop described in this report was conducted May 21-25, 1984, at the Kennedy Space Center to: (1) enhance communication among the agencies with management responsibilities on Merritt Island; (2) integrate available information concerning the development, management, and ecology of Merritt Island; and (3) identify key research and monitoring needs associated with the management and use of the island's resources. The workshop was structured around the formulation of a model that would simulate primary management and use activities on Merritt Island and their effects on upland, impoundment, and estuarine vegetation and associated wildlife. The simulation model is composed of

  12. Study on the distribution of active centers in novel low Ti-loading MgCl2-supported Ziegler-Natta catalyst

    Institute of Scientific and Technical Information of China (English)

    王剑峰; 王立; 赵振荣; 王文钦; 陈涛

    2004-01-01

    Novel MgCl2-supported Ziegler-Natta (Z-N) catalysts prepared using a new one-pot ball milling method can effectively control the amounts of Ti-loading in the catalysts. Complex GPC data on polypropylene synthesized by these novel catalysts were analyzed using the method of fitting the molecular weight distribution (MWD) curves with a multiple Flory-Schulz function. It was found that multiple active centers exist in these novel catalysts. Detailed study of the effects of the Ti-loadings in the catalysts on the distribution of the active centers showed that the Ti-loadings in the novel MgCl2-supported Z-N catalysts might affect the proportion of each type of active centers; and might be the main factor responsible for the effect of the Ti-loadings on the microstructure, the molecular weight and molecular weight distribution width of the resultant polymer, the catalytic activity and polymerization kinetics.

  13. Annual report of R and D activities in center for promotion of computational science and engineering from April 1, 2003 to March 31, 2004

    International Nuclear Information System (INIS)

    Major Research and development activities of Center for Promotion of Computational Science and Engineering (CCSE), JAERI, have focused on ITBL (IT Based Laboratory) project, computational material science and Quantum Bioinformatics. This report provides an overview of research and development activities in (CCSE) in the fiscal year 2003 (April 1, 2003 - March 31, 2004). (author)

  14. Designing a functional type 2 copper center that has nitrite reductase activity within α-helical coiled coils.

    Science.gov (United States)

    Tegoni, Matteo; Yu, Fangting; Bersellini, Manuela; Penner-Hahn, James E; Pecoraro, Vincent L

    2012-12-26

    One of the ultimate objectives of de novo protein design is to realize systems capable of catalyzing redox reactions on substrates. This goal is challenging as redox-active proteins require design considerations for both the reduced and oxidized states of the protein. In this paper, we describe the spectroscopic characterization and catalytic activity of a de novo designed metallopeptide Cu(I/II)(TRIL23H)(3)(+/2+), where Cu(I/II) is embeded in α-helical coiled coils, as a model for the Cu(T2) center of copper nitrite reductase. In Cu(I/II)(TRIL23H)(3)(+/2+), Cu(I) is coordinated to three histidines, as indicated by X-ray absorption data, and Cu(II) to three histidines and one or two water molecules. Both ions are bound in the interior of the three-stranded coiled coils with affinities that range from nano- to micromolar [Cu(II)], and picomolar [Cu(I)]. The Cu(His)(3) active site is characterized in both oxidation states, revealing similarities to the Cu(T2) site in the natural enzyme. The species Cu(II)(TRIL23H)(3)(2+) in aqueous solution can be reduced to Cu(I)(TRIL23H)(3)(+) using ascorbate, and reoxidized by nitrite with production of nitric oxide. At pH 5.8, with an excess of both the reductant (ascorbate) and the substrate (nitrite), the copper peptide Cu(II)(TRIL23H)(3)(2+) acts as a catalyst for the reduction of nitrite with at least five turnovers and no loss of catalytic efficiency after 3.7 h. The catalytic activity, which is first order in the concentration of the peptide, also shows a pH dependence that is described and discussed. PMID:23236170

  15. Laboratory-confirmed HIV and sexually transmitted infection seropositivity and risk behavior among sexually active transgender patients at an adolescent and young adult urban community health center

    OpenAIRE

    Reisner, Sari L.; Vetters, Ralph; White, Jaclyn M.; Cohen, Elijah L.; Leclerc, M; Zaslow, Shayne; Wolfrum, Sarah; Mimiaga, Matthew J.

    2015-01-01

    The sexual health of transgender adolescents and young adults who present for health care in urban community health centers is understudied. A retrospective review of electronic health record (EHR) data was conducted from 180 transgender patients aged 12–29 years seen for one or more health-care visits between 2001 and 2010 at an urban community health center serving youth in Boston, MA. Analyses were restricted to 145 sexually active transgender youth (87.3% of the sample). Laboratory-confir...

  16. Excellence in Physics Education Award: SCALE-UP, Student Centered Active Learning Environment with Upside-down Pedagogies

    Science.gov (United States)

    Beichner, Robert

    2016-03-01

    The Student-Centered Active Learning Environment with Upside-down Pedagogies (SCALE-UP) Project combines curricula and a specially-designed instructional space to enhance learning. SCALE-UP students practice communication and teamwork skills while performing activities that enhance their conceptual understanding and problem solving skills. This can be done with small or large classes and has been implemented at more than 250 institutions. Educational research indicates that students should collaborate on interesting tasks and be deeply involved with the material they are studying. SCALE-UP classtime is spent primarily on ``tangibles'' and ``ponderables''--hands-on measurements/observations and interesting questions. There are also computer simulations (called ``visibles'') and hypothesis-driven labs. Students sit at tables designed to facilitate group interactions. Instructors circulate and engage in Socratic dialogues. The setting looks like a banquet hall, with lively interactions nearly all the time. Impressive learning gains have been measured at institutions across the US and internationally. This talk describes today's students, how lecturing got started, what happens in a SCALE-UP classroom, and how the approach has spread. The SCALE-UP project has greatly benefitted from numerous Grants made by NSF and FIPSE to NCSU and other institutions.

  17. Technology Information Center

    International Nuclear Information System (INIS)

    A Transportation Technology Center (TTC) has been established at Sandia to address the transportation of nuclear waste and spent fuel. The Technology Information Center (TIC) acts as TTC's clearing house for nuclear material transportation information. TIC's activities are divided into three activities: public information, policy information, and technical information. Some of the uses of TIC's activities are briefly outlined

  18. JPSS Proving Ground Activities with NASA's Short-term Prediction Research and Transition (SPoRT) Center

    Science.gov (United States)

    Schultz, L. A.; Smith, M. R.; Fuell, K.; Stano, G. T.; LeRoy, A.; Berndt, E.

    2015-12-01

    Instruments aboard the Joint Polar Satellite System (JPSS) series of satellites will provide imagery and other data sets relevant to operational weather forecasts. To prepare current and future weather forecasters in application of these data sets, Proving Ground activities have been established that demonstrate future JPSS capabilities through use of similar sensors aboard NASA's Terra and Aqua satellites, and the S-NPP mission. As part of these efforts, NASA's Short-term Prediction Research and Transition (SPoRT) Center in Huntsville, Alabama partners with near real-time providers of S-NPP products (e.g., NASA, UW/CIMSS, UAF/GINA, etc.) to demonstrate future capabilities of JPSS. This includes training materials and product distribution of multi-spectral false color composites of the visible, near-infrared, and infrared bands of MODIS and VIIRS. These are designed to highlight phenomena of interest to help forecasters digest the multispectral data provided by the VIIRS sensor. In addition, forecasters have been trained on the use of the VIIRS day-night band, which provides imagery of moonlit clouds, surface, and lights emitted by human activities. Hyperspectral information from the S-NPP/CrIS instrument provides thermodynamic profiles that aid in the detection of extremely cold air aloft, helping to map specific aviation hazards at high latitudes. Hyperspectral data also support the estimation of ozone concentration, which can highlight the presence of much drier stratospheric air, and map its interaction with mid-latitude or tropical cyclones to improve predictions of their strengthening or decay. Proving Ground activities are reviewed, including training materials and methods that have been provided to forecasters, and forecaster feedback on these products that has been acquired through formal, detailed assessment of their applicability to a given forecast threat or task. Future opportunities for collaborations around the delivery of training are proposed

  19. New Horizons at Pluto: An Overview of Educational Activities / Outreach at Fernbank Science Center, Atlanta, Georgia (USA)

    Science.gov (United States)

    Albin, Edward F.; Harris, R. Scott

    2015-11-01

    We report on educational activities and associated outreach at Fernbank Science Center (Atlanta, GA) in conjunction with the July 2015 New Horizons spacecraft encounter at Pluto. On encounter day, a public lecture about the dwarf planet was presented by Georgia’s NASA Solar System ambassador to kick off the arrival of the space probe at Pluto. In the months following the flyby, we presented a program called “Exploring New Horizons” in the Science Center’s Zeiss planetarium. This program is a digital full-dome presentation about the discovery of Pluto and its subsequent exploration - including an overview of the New Horizons mission. Since NASA continues to receive data from the probe, a brief update (tribute) is included at the end of each planetarium program that features the latest imagery and data from the dwarf planet. We anticipate running the planetarium program throughout the fall semester of 2015. With Pluto visible in the early evening autumn sky, observations are possible with Center’s 0.9 m telescope, which is open for public viewing on clear Thursday and Friday nights following the planetarium program. Although Pluto is somewhat faint through the telescope's eyepiece, it is visible and clearly identified within the surrounding starfield. Intermittent post-encounter lectures ("Messages from the Outer Solar System") have been given on Friday evenings as well. Finally, due to the continued interest in Pluto, we have developed a new outreach program about dwarf planets in general, geared towards 4th - 6th students.

  20. Lessons learned from four years of actively using River Forecast Center Ensemble Streamflow Predictions to inform reservoir management

    Science.gov (United States)

    Polebitski, A.; Palmer, R.; Meaker, B.

    2012-12-01

    The National Weather Service's River Forecast Centers (RFCs), located throughout the US, produce operational streamflow forecasts for short term application and long-term lead forecasts at selected locations. These forecasts are targeted for a variety of users, including water supply management, flood control, hydropower production, navigation, and recreation. This presentation highlights the challenges and successes associated with the use of RFC produced ensemble streamflow predictions (ESP) in generating system operations forecasts over the past four years for Snohomish County Public Utility District #1's (SnoPUD) Henry Jackson hydropower system. This research documents a multiyear collaboration between SnoPUD and academic researchers. The collaboration began with a proof of concept study in 2007 and evolved into a weekly decision support activity that has been ongoing since 2008 ( documented in Alemu et al. 2010). The Alemu et al. paper demonstrates the usefulness of ESP forecasts in hydropower operations decision making. This paper focuses on the value of forecasts and a decision support system (DSS) in improving skills in operating reservoir systems. During the application period, the model provided weekly guidance on meeting operational objectives and a probabilistic approach to quantifying system vulnerability during critical periods such as floods and drought. The ESP forecasts and the DSS were heavily used during periods of uncertainty and less so during periods of high system constraint or low system risk.

  1. Structures and Metal-Binding Properties of Helicobacter pylori Neutrophil-Activating Protein with a Di-Nuclear Ferroxidase Center

    Directory of Open Access Journals (Sweden)

    Hideshi Yokoyama

    2014-06-01

    Full Text Available Helicobacter pylori causes severe diseases, such as chronic gastritis, peptic ulcers, and stomach cancers. H. pylori neutrophil-activating protein (HP-NAP is an iron storage protein that forms a dodecameric shell, promotes the adhesion of neutrophils to endothelial cells, and induces the production of reactive oxygen radicals. HP-NAP belongs to the DNA-protecting proteins under starved conditions (Dps family, which has significant structural similarities to the dodecameric ferritin family. The crystal structures of the apo form and metal-ion bound forms, such as iron, zinc, and cadmium, of HP-NAP have been determined. This review focused on the structures and metal-binding properties of HP-NAP. These metal ions bind at the di-nuclear ferroxidase center (FOC by different coordinating patterns. In comparison with the apo structure, metal loading causes a series of conformational changes in conserved residues among HP-NAP and Dps proteins (Trp26, Asp52, and Glu56 at the FOC. HP-NAP forms a spherical dodecamer with 23 symmetry including two kinds of pores. Metal ions have been identified around one of the pores; therefore, the negatively-charged pore is suitable for the passage of metal ions.

  2. A Broadly-Based Training Program in Volcano Hazards Monitoring at the Center for the Study of Active Volcanoes

    Science.gov (United States)

    Thomas, D. M.; Bevens, D.

    2015-12-01

    The Center for the Study of Active Volcanoes, in cooperation with the USGS Volcano Hazards Program at HVO and CVO, offers a broadly based volcano hazards training program targeted toward scientists and technicians from developing nations. The program has been offered for 25 years and provides a hands-on introduction to a broad suite of volcano monitoring techniques, rather than detailed training with just one. The course content has evolved over the life of the program as the needs of the trainees have changed: initially emphasizing very basic monitoring techniques (e.g. precise leveling, interpretation of seismic drum records, etc.) but, as the level of sophistication of the trainees has increased, training in more advanced technologies has been added. Currently, topics of primary emphasis have included volcano seismology and seismic networks; acquisition and modeling of geodetic data; methods of analysis and monitoring of gas geochemistry; interpretation of volcanic deposits and landforms; training in LAHARZ, GIS mapping of lahar risks; and response to and management of volcanic crises. The course also provides training on public outreach, based on CSAV's Hawaii-specific hazards outreach programs, and volcano preparedness and interactions with the media during volcanic crises. It is an intensive eight week course with instruction and field activities underway 6 days per week; it is now offered in two locations, Hawaii Island, for six weeks, and the Cascades volcanoes of the Pacific Northwest, for two weeks, to enable trainees to experience field conditions in both basaltic and continental volcanic environments. The survival of the program for more than two decades demonstrates that a need for such training exists and there has been interaction and contribution to the program by the research community, however broader engagement with the latter continues to present challenges. Some of the reasons for this will be discussed.

  3. IRASM Center

    International Nuclear Information System (INIS)

    IRASM is a national center for radiation processing developed around an industrial Co60 gamma irradiator. Being a department in an R and D national institute, IRASM Center is dealing with radiation treatment, pre/post microbiological control, validation of irradiation sterilization, detection of irradiated foodstuffs. Training is available for operators of new irradiation facilities focused on radiation technologies, dosimetry, sterilization, food treatment, conservation by irradiation of cultural heritage, quality assurance. Expertise on proper choosing the plastics for packaging versus dose is offered to the potential clients. IRASM Center is also involved in interdisciplinary applied research like chitosan treatment, sterile male technique or implementation of irradiation step in production of pharmaceuticals. All important activities: irradiation treatment, dosimetry, microbiology, detection of irradiated food, radioprotection, nuclear safety, physical protection. are performed in accordance with the proper standards in the frame of a certified quality management system. In this way Co60 industrial sources, a byproduct of certain nuclear power plants like Candu type, appear to be the key of a large technical and R and D domain. (authors)

  4. Centro Regional de Ciencias Nucleares (a Brazilian regional center for nuclear sciences) - activities report - 1999; Centro Regional de Ciencias Nucleares - relatorio de atividades - 1999

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-12-01

    The annual activities report of 1999 of nuclear sciences regional center - Brazilian organization - introduces the next main topics: institutional relations; sectorial actions - logistic support and training, laboratory of radiation protection and dosimetry, laboratory of metrology, laboratory of chemical characterization; technical and scientific events; and financial resources and perspectives for 2000.

  5. Prediction of attendance at fitness center : a comparison between the theory of planned behavior, the social cognitive theory, and the physical activity maintenance theory

    OpenAIRE

    Jekauc, Darko; Völkle, Manuel; Wagner, Matthias O.; Mess, Filip; Reiner, Miriam; Renner, Britta

    2015-01-01

    In the processes of physical activity (PA) maintenance specific predictors are effective, which differ from other stages of PA development. Recently, Physical Activity Maintenance Theory (PAMT) was specifically developed for prediction of PA maintenance. The aim of the present study was to evaluate the predictability of the future behavior by the PAMT and compare it with the Theory of Planned Behavior (TPB) and Social Cognitive Theory (SCT). Participation rate in a fitness center was observed...

  6. Hematopoietic Stem Cell Transplantation Activity and Trends at a Pediatric Transplantation Center in Turkey During 1998-2008

    Directory of Open Access Journals (Sweden)

    Volkan Hazar

    2012-06-01

    Full Text Available OBJECTIVE: The aim of this study was to document hematopoietic stem cell transplantation (HSCT activity and trends at our treatment center. METHODS: Data collected over a 10-year period were retrospectively analyzed, concentrating primarily on types of HSCT, transplant-related mortality (TRM, stem cell sources, indications for HSCT, and causes of death following HSCT. RESULTS: In total, 222 allogeneic (allo-HSCT (87.4% and 32 autologous (auto-HSCT (12.6% procedures were performed between 1998 and 2008. Stem cells obtained from unrelated donors were used in 22.6% (50/222 of the allo- HSCTs. Cord blood was the source of hematopoietic stem cells (HSC in 12.2% of all transplants. The most common indication for allo-HSCT was hemoglobinopathy (43.2%, versus neuroblastoma (53.1% for auto-HSCT. The TRM rate 1 year post transplantation was 18.3% ± 2.5% for all transplants, but differed according to transplantation type (23.5% ± 7.9% for auto-HSCT and 17.5% ± 2.6% for allo-HSCT. The most common cause of death 1 year post HSCT was infection (35.9%. CONCLUSION: The TRM rate in the patients that underwent allo-HSCT was similar to that which has been previously reported; however, the TRM rate in the patients that underwent auto-HSCT was higher than previously reported in developed countries. The selection of these patients to be transplanted must be made attentively.

  7. Customer Support Operations In Support Of The NASA/JPL Physical Oceanography Distributed Active Archive Center (PO.DAAC)

    Science.gov (United States)

    Heinz, S. L.; Chen, Y. M.

    2004-12-01

    PO.DAAC is responsible for the ingest, archive and distribution of data relevant to the physical state of the ocean. The PO.DAAC provides a level of service for customer support for core Earth Observing System Data Information System (EOSDIS) missions such as TOPEX/POSEIDON, Jason, SeaWinds on QuikSCAT, SeaWinds on ADEOS-II, NOAA AVHRR and MODIS. PO.DAAC's level of support has broadened recently to include missions outside of the EOSDIS including, WindSat, GHRSST, Naval Oceanographic, Monterey Bay Aquarium, AirSAR and GOES. Customer support operations is managed and conducted in partnership between Raytheon ITSS and JPL and includes a full complement of services to accommodate the various PO.DAAC and Earth Observing System user communities. Customer support activities are ubiquitous to service industries from banking to shopping and this presentation will detail how two operational applications have been adopted for use in Earth Science data communities. Customer Response Management Operations System Integrated system that combines PO.DAAC's communications channels including web, email, phone and personal interactions into one intelligent knowledge base. The knowledge is shared with customers and the entire team to deliver consistent and timely information. The system allows 24 x 7 customer support service via extensive on-line searchable knowledge base. PO.DAAC has customized the system to fully integrate with PO.DAAC's existing legacy database and order tracking system. Website Communication Channel The newly redesigned PO.DAAC website (http://podaac.jpl.nasa.gov) is the central gateway to all of the Data, Tools and Services offered at the data center. The consistent look and feel was developed to enhance the ease of searching and ordering earth science data in particular. Data is accessible within a few clicks using the improved dynamic data catalog interface. New data products and information are delivered quickly to customers via the dynamic system and

  8. Site Energies of Active and Inactive Pheophytins in the Reaction Center of Photosystem II from Chlamydomonas Reinhardtii

    International Nuclear Information System (INIS)

    It is widely accepted that the primary electron acceptor in various Photosystem II (PSII) reaction center (RC) preparations is pheophytin α (Pheo α) within the D1 protein (PheoD1), while PheoD2 (within the D2 protein) is photochemically inactive. The Pheo site energies, however, have remained elusive, due to inherent spectral congestion. While most researchers over the past two decades placed the Qy-states of PheoD1 and PheoD2 bands near 678-684 and 668-672 nm, respectively, recent modeling (Raszewski et al. Biophys. J. 2005, 88, 986-998; Cox et al. J. Phys. Chem. B 2009, 113, 12364-12374) of the electronic structure of the PSII RC reversed the assignment of the active and inactive Pheos, suggesting that the mean site energy of PheoD1 is near 672 nm, whereas PheoD2 (∼677.5 nm) and ChlD1 (∼680 nm) have the lowest energies (i.e., the PheoD2-dominated exciton is the lowest excited state). In contrast, chemical pigment exchange experiments on isolated RCs suggested that both pheophytins have their Qy absorption maxima at 676-680 nm (Germano et al. Biochemistry 2001, 40, 11472-11482; Germano et al. Biophys. J. 2004, 86, 1664-1672). To provide more insight into the site energies of both PheoD1 and PheoD2 (including the corresponding Qx transitions, which are often claimed to be degenerate at 543 nm) and to attest that the above two assignments are most likely incorrect, we studied a large number of isolated RC preparations from spinach and wild-type Chlamydomonas reinhardtii (at different levels of intactness) as well as the Chlamydomonas reinhardtii mutant (D2-L209H), in which the active branch PheoD1 is genetically replaced with chlorophyll α (Chl α). We show that the Qx-/Qy-region site energies of PheoD1 and PheoD2 are ∼545/680 nm and ∼541.5/670 nm, respectively, in good agreement with our previous assignment (Jankowiak et al. J. Phys. Chem. B 2002, 106, 8803?8814). The latter values should be used to model excitonic structure and excitation energy

  9. Evaluation of Anatomical and Functional Hip Joint Center Methods: The Effects of Activity Type, Gender, and Proximal Reference Segment.

    Science.gov (United States)

    McGibbon, C A; Fowler, J; Chase, S; Steeves, K; Landry, J; Mohamed, A

    2016-01-01

    Accurate hip joint center (HJC) location is critical when studying hip joint biomechanics. The HJC is often determined from anatomical methods, but functional methods are becoming increasingly popular. Several studies have examined these methods using simulations and in vivo gait data, but none has studied high-range of motion activities, such a chair rise, nor has HJC prediction been compared between males and females. Furthermore, anterior superior iliac spine (ASIS) marker visibility during chair rise can be problematic, requiring a sacral cluster as an alternative proximal segment; but functional HJC has not been explored using this approach. For this study, the quality of HJC measurement was based on the joint gap error (JGE), which is the difference in global HJC between proximal and distal reference segments. The aims of the present study were to: (1) determine if JGE varies between pelvic and sacral referenced HJC for functional and anatomical methods, (2) investigate which functional calibration motion results in the lowest JGE and if the JGE varies depending on movement type (gait versus chair rise) and gender, and (3) assess whether the functional HJC calibration results in lower JGE than commonly used anatomical approaches and if it varies with movement type and gender. Data were collected on 39 healthy adults (19 males and 20 females) aged 14-50 yr old. Participants performed four hip "calibration" tests (arc, cross, star, and star-arc), as well as gait and chair rise (activities of daily living (ADL)). Two common anatomical methods were used to estimate HJC and were compared to HJC computed using a published functional method with the calibration motions above, when using pelvis or sacral cluster as the proximal reference. For ADL trials, functional methods resulted in lower JGE (12-19 mm) compared to anatomical methods (13-34 mm). It was also found that women had significantly higher JGE compared to men and JGE was significantly higher for

  10. Site Energies of Active and Inactive Pheophytins in the Reaction Center of Photosystem II from Chlamydomonas Reinhardtii

    Energy Technology Data Exchange (ETDEWEB)

    Acharya, K.; Neupane, B.; Zazubovich, V.; Sayre, R. T.; Picorel, R.; Seibert, M.; Jankowiak, R.

    2012-03-29

    It is widely accepted that the primary electron acceptor in various Photosystem II (PSII) reaction center (RC) preparations is pheophytin {alpha} (Pheo {alpha}) within the D1 protein (Pheo{sub D1}), while Pheo{sub D2} (within the D2 protein) is photochemically inactive. The Pheo site energies, however, have remained elusive, due to inherent spectral congestion. While most researchers over the past two decades placed the Q{sub y}-states of Pheo{sub D1} and Pheo{sub D2} bands near 678-684 and 668-672 nm, respectively, recent modeling [Raszewski et al. Biophys. J. 2005, 88, 986-998; Cox et al. J. Phys. Chem. B 2009, 113, 12364-12374] of the electronic structure of the PSII RC reversed the assignment of the active and inactive Pheos, suggesting that the mean site energy of Pheo{sub D1} is near 672 nm, whereas Pheo{sub D2} ({approx}677.5 nm) and Chl{sub D1} ({approx}680 nm) have the lowest energies (i.e., the Pheo{sub D2}-dominated exciton is the lowest excited state). In contrast, chemical pigment exchange experiments on isolated RCs suggested that both pheophytins have their Q{sub y} absorption maxima at 676-680 nm [Germano et al. Biochemistry 2001, 40, 11472-11482; Germano et al. Biophys. J. 2004, 86, 1664-1672]. To provide more insight into the site energies of both Pheo{sub D1} and Pheo{sub D2} (including the corresponding Q{sub x} transitions, which are often claimed to be degenerate at 543 nm) and to attest that the above two assignments are most likely incorrect, we studied a large number of isolated RC preparations from spinach and wild-type Chlamydomonas reinhardtii (at different levels of intactness) as well as the Chlamydomonas reinhardtii mutant (D2-L209H), in which the active branch Pheo{sub D1} is genetically replaced with chlorophyll {alpha} (Chl {alpha}). We show that the Q{sub x}-/Q{sub y}-region site energies of Pheo{sub D1} and Pheo{sub D2} are {approx}545/680 nm and {approx}541.5/670 nm, respectively, in good agreement with our previous assignment

  11. A proposal for improving data center management through strategic implementation of Server virtualization technology to support Malaysian Nuclear Agency's activities

    International Nuclear Information System (INIS)

    Management of servers in Nuclear Malaysia's data center poses a big challenge to IT Center as well as to the general management. Traditional server management techniques have been used to provide reliable and continuous support for the ever increasing services and applications demanded by researchers and the other staffs of Nuclear Malaysia. Data centers are cost centers which need logistical support such as electricity, air conditioning, room space, manpower and other resources. To save cost and comply with Green Technology while maintaining or improving the level of services, a new concept called server virtualization is proposed and a feasibility study of this technology has been initiated to explore its potential to accommodate IT centers ever demanding services while reducing the need for such logistical supports, hence adhering to the Green IT concept. Server virtualization is a new technology where a single high performance physical server can host multiple high processing services, and different types operating systems with different hardware and software requirements which are traditionally performed by multiple server machines. This paper briefly explains server virtualization concepts, tools and techniques and proposes an implementation strategy of the technology for Nuclear Malaysia's data center. (author)

  12. Effects of supported (nBuCp)2ZrCl2 catalyst active center multiplicity on crystallization kinetics of ethylene homo- and copolymers

    KAUST Repository

    Atiqullah, Muhammad

    2014-07-01

    Two different supported zirconocene, that is, bis(n-butylcyclopentadienyl) zirconium dichloride (nBuCp)2ZrCl2, catalysts were synthesized. Each catalyst was used to prepare one ethylene homopolymer and one ethylene-1-hexene copolymer. Catalyst active center multiplicity and polymer crystallization kinetics were modeled. Five separate active center types were predicted, which matched the successive self-nucleation and annealing (SSA) peak temperatures. The predicted crystallinity well matched the differential scanning calorimetric (DSC) values for a single Avrami-Erofeev index, which ranged between 2 and 3 for the polymers experimented. The estimated apparent crystallization activation energy Ea did not vary with cooling rates, relative crystallinity α, and crystallization time or temperature. Therefore, the concept of variable/instantaneous activation energy was not found to hold. Ea linearly increased with the weight average lamellar thickness Lwav DSC-GT; and for each homopolymer, it exceeded that of the corresponding copolymer. Higher Ea, hence slower crystallization, was identified as a pre-requisite to attain higher crystallinity. Crystallization parameters were correlated to polymer backbone parameters, which are influenced by catalyst active center multiplicity. © 2013 Taiwan Institute of Chemical Engineers.

  13. Silica-supported (nBuCp)2ZrCl2: Effect of catalyst active center distribution on ethylene-1-hexene copolymerization

    KAUST Repository

    Atiqullah, Muhammad

    2013-08-12

    Metallocenes are a modern innovation in polyolefin catalysis research. Therefore, two supported metallocene catalysts-silica/MAO/(nBuCp)2ZrCl2 (Catalyst 1) and silica/nBuSnCl3/MAO/(nBuCp)2ZrCl2 (Catalyst 2), where MAO is methylaluminoxane-were synthesized, and subsequently used to prepare, without separate feeding of MAO, ethylene-1-hexene Copolymer 1 and Copolymer 2, respectively. Fouling-free copolymerization, catalyst kinetic stability and production of free-flowing polymer particles (replicating the catalyst particle size distribution) confirmed the occurrence of heterogeneous catalysis. The catalyst active center distribution was modeled by deconvoluting the measured molecular weight distribution and copolymer composition distribution. Five different active center types were predicted for each catalyst, which was corroborated by successive self-nucleation and annealing experiments, as well as by an extended X-ray absorption fine structure spectroscopy report published in the literature. Hence, metallocenes impregnated particularly on an MAO-pretreated support may be rightly envisioned to comprise an ensemble of isolated single sites that have varying coordination environments. This study shows how the active center distribution and the design of supported MAO anions affect copolymerization activity, polymerization mechanism and the resulting polymer microstructures. Catalyst 2 showed less copolymerization activity than Catalyst 1. Strong chain transfer and positive co-monomer effect-both by 1-hexene-were common. Each copolymer demonstrated vinyl, vinylidene and trans-vinylene end groups, and compositional heterogeneity. All these findings were explained, as appropriate, considering the modeled active center distribution, MAO cage structure repeat units, proposed catalyst surface chemistry, segregation effects and the literature that concerns and supports this study. While doing so, new insights were obtained. Additionally, future research, along the direction

  14. Annual report of R and D activities in Center for Computational Science and e-Systems from April 1, 2006 to March 31, 2007

    International Nuclear Information System (INIS)

    This report provides an overview of the research and development activities of the Center for Computational Science and e-Systems (CCSE), JAEA in fiscal year 2006 (April 1, 2006 - March 31, 2007). These research and development activities have been performed by the Simulation Technology Research and Development Office and the Computer Science Research and Development Office. The primary results of the research and development activities are the development of simulation techniques for a virtual earthquake testbed, an intelligent infrastructure for atomic energy research, computational biological disciplines to predict DNA repair function of protein, and material models for a neutron detection device, crack propagation, and gas bubble formation in nuclear fuel. (author)

  15. Hastings Center

    Science.gov (United States)

    ... Public Events October 19, Hastings Center Seminar, Garrison : Human Genetic Engineering: Wh at Can We Do? What Should We ... Public Events October 19, Hastings Center Seminar, Garrison : Human Genetic Engineering: Wh at Can We Do? What Should We ...

  16. Sugar beet activities of the USDA-ARS East Lansing conducted in cooperation with Saginaw Research & Extension Center during 2014

    Science.gov (United States)

    Evaluation and rating plots were planted at the Saginaw Valley Research & Extension Center (SVREC) in Frankenmuth, MI in 2014 that focused on Cercospora leaf spot (CLS) and Rhizoctonia crown and root rot (CRR) disease performance of a wide range of Beta vulgaris materials. CLS and CRR trials were co...

  17. Asymmetric Desymmetrization via Metal-Free C-F Bond Activation: Synthesis of 3,5-Diaryl-5-fluoromethyloxazolidin-2-ones with Quaternary Carbon Centers.

    Science.gov (United States)

    Tanaka, Junki; Suzuki, Satoru; Tokunaga, Etsuko; Haufe, Günter; Shibata, Norio

    2016-08-01

    We disclose the first asymmetric activation of a non-activated aliphatic C-F bond in which a conceptually new desymmetrization of 1,3-difluorides by silicon-induced selective C-F bond scission is a key step. The combination of a cinchona alkaloid based chiral ammonium bifluoride catalyst and N,O-bis(trimethylsilyl)acetoamide (BSA) as the silicon reagent enabled the efficient catalytic cycle of asymmetric Csp3 -F bond cleavage under mild conditions with high enantioselectivities. The ortho effect of the aryl group at the prostereogenic center is remarkable. This concept was applied for the asymmetric synthesis of promising agrochemical compounds, 3,5-diaryl-5-fluoromethyloxazolidin-2-ones bearing a quaternary carbon center.

  18. Excel Center

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Citigroup,one of the World top 500 companies,has now settled in Excel Center,Financial Street. The opening ceremony of Excel Center and the entry ceremony of Citigroup in the center were held on March 31.Government leaders of Xicheng District,the Excel CEO and the heads of Asia-Pacific Region leaders of Citibank all participated in the ceremony.

  19. Trunk muscle co-activation using functional electrical stimulation modifies center of pressure fluctuations during quiet sitting by increasing trunk stiffness

    OpenAIRE

    Milosevic, Matija; Masani, Kei; Wu, Noel; McConville, Kristiina M. V.; Popovic, Milos R.

    2015-01-01

    Background The purpose of this study was to examine the impact of functional electrical stimulation (FES) induced co-activation of trunk muscles during quiet sitting. We hypothesized that FES applied to the trunk muscles will increase trunk stiffness. The objectives of this study were to: 1) compare the center of pressure (COP) fluctuations during unsupported and FES-assisted quiet sitting - an experimental study and; 2) investigate how FES influences sitting balance - an analytical (simulati...

  20. A student-centered approach for developing active learning: the construction of physical models as a teaching tool in medical physiology

    OpenAIRE

    Rezende-Filho, F.M.; da Fonseca, L.J.S.; Nunes-Souza, V.; Da Silva Guedes, G.; Rabelo, L.A.

    2014-01-01

    BACKGROUND: Teaching physiology, a complex and constantly evolving subject, is not a simple task. A considerable body of knowledge about cognitive processes and teaching and learning methods has accumulated over the years, helping teachers to determine the most efficient way to teach, and highlighting student's active participation as a means to improve learning outcomes. In this context, this paper describes and qualitatively analyzes an experience of a student-centered teaching-learning met...

  1. Flip flops, dress clothes, and no coat: clothing barriers to children's physical activity in child-care centers identified from a qualitative study

    Directory of Open Access Journals (Sweden)

    Saelens Brian E

    2009-11-01

    Full Text Available Abstract Background Three-quarters of 3-6 year-old children in the U.S. spend time in childcare; many spend most of their waking hours in these settings. Daily physical activity offers numerous health benefits, but activity levels vary widely across centers. This study was undertaken to explore reasons why physical activity levels may vary. The purpose of this paper is to summarize an unexpected finding that child-care providers cited was a key barrier to children's physical activity. Methods Nine focus groups with 49 child-care providers (55% black from 34 centers (including inner-city, suburban, Head Start and Montessori were conducted in Cincinnati, OH. Three independent raters analyzed verbatim transcripts for themes. Several techniques were used to increase credibility of findings, including interviews with 13 caregivers. Results Two major themes about clothing were: 1 children's clothing was a barrier to children's physical activity in child-care, and 2 clothing choices were a significant source of conflict between parents and child-care providers. Inappropriate clothing items included: no coat/hat/gloves in the wintertime, flip flops or sandals, dress/expensive clothes, jewelry, and clothes that were either too loose or too tight. Child-care providers explained that unless there were enough extra coats at the center, a single child without a coat could prevent the entire class from going outside. Caregivers suggested several reasons why parents may dress their child inappropriately, including forgetfulness, a rushed morning routine, limited income to buy clothes, a child's preference for a favorite item, and parents not understanding the importance of outdoor play. Several child-care providers favored specific policies prohibiting inappropriate clothing, as many reported limited success with verbal or written reminders to bring appropriate clothing. Conclusion Inappropriate clothing may be an important barrier to children's physical

  2. Communication between thiamin cofactors in the Escherichia coli pyruvate dehydrogenase complex E1 component active centers: evidence for a "direct pathway" between the 4'-aminopyrimidine N1' atoms.

    Science.gov (United States)

    Nemeria, Natalia S; Arjunan, Palaniappa; Chandrasekhar, Krishnamoorthy; Mossad, Madouna; Tittmann, Kai; Furey, William; Jordan, Frank

    2010-04-01

    Kinetic, spectroscopic, and structural analysis tested the hypothesis that a chain of residues connecting the 4'-aminopyrimidine N1' atoms of thiamin diphosphates (ThDPs) in the two active centers of the Escherichia coli pyruvate dehydrogenase complex E1 component provides a signal transduction pathway. Substitution of the three acidic residues (Glu(571), Glu(235), and Glu(237)) and Arg(606) resulted in impaired binding of the second ThDP, once the first active center was filled, suggesting a pathway for communication between the two ThDPs. 1) Steady-state kinetic and fluorescence quenching studies revealed that upon E571A, E235A, E237A, and R606A substitutions, ThDP binding in the second active center was affected. 2) Analysis of the kinetics of thiazolium C2 hydrogen/deuterium exchange of enzyme-bound ThDP suggests half-of-the-sites reactivity for the E1 component, with fast (activated site) and slow exchanging sites (dormant site). The E235A and E571A variants gave no evidence for the slow exchanging site, indicating that only one of two active sites is filled with ThDP. 3) Titration of the E235A and E237A variants with methyl acetylphosphonate monitored by circular dichroism suggested that only half of the active sites were filled with a covalent predecarboxylation intermediate analog. 4) Crystal structures of E235A and E571A in complex with ThDP revealed the structural basis for the spectroscopic and kinetic observations and showed that either substitution affects cofactor binding, despite the fact that Glu(235) makes no direct contact with the cofactor. The role of the conserved Glu(571) residue in both catalysis and cofactor orientation is revealed by the combined results for the first time. PMID:20106967

  3. Simple Machine Science Centers

    Science.gov (United States)

    Chessin, Debby

    2007-01-01

    Science centers can engage students; accommodate different learning styles and individual interests; help students become independent and confident learners; and encourage social skills among students. In this article, the author worked with third-grade students as they completed activities at learning centers during a week-long unit on simple…

  4. The 3 Ms Chandra Campaign on Sgr A*: A Census of X-ray Flaring Activity from the Galactic Center

    CERN Document Server

    Neilsen, J; Gammie, C; Dexter, J; Markoff, S; Haggard, D; Nayakshin, S; Wang, Q D; Grosso, N; Porquet, D; Tomsick, J A; Degenaar, N; Fragile, P C; Houck, J C; Wijnands, R; Miller, J M; Baganoff, F K

    2013-01-01

    Over the last decade, X-ray observations of Sgr A* have revealed a black hole in a deep sleep, punctuated roughly once per day by brief flares. The extreme X-ray faintness of this supermassive black hole has been a long-standing puzzle in black hole accretion. To study the accretion processes in the Galactic Center, Chandra (in concert with numerous ground- and space-based observatories) undertook a 3 Ms campaign on Sgr A* in 2012. With its excellent observing cadence, sensitivity, and spectral resolution, this Chandra X-ray Visionary Project (XVP) provides an unprecedented opportunity to study the behavior of the closest supermassive black hole. We present a progress report from our ongoing study of X-ray flares, including the brightest flare ever seen from Sgr A*. Focusing on the statistics of the flares and the quiescent emission, we discuss the physical implications of X-ray variability in the Galactic Center.

  5. MONITORING OF THE EDUCATIONAL ADULT CENTER: SEEKING WAYS FOR IMPROVING THE ACTIVITY WITH PEOPLE OF "THE THIRD AGE"

    Directory of Open Access Journals (Sweden)

    Isimbaev Erkin

    2015-12-01

    Full Text Available The authors discuss the experience of the educational adult center in the context of the idea - "education throughout the life". In the frame of the last three years the Centre organized the monitoring and analytical work to create a system of education and finding ways to improve the efficiency of working with people of "the third age". The article presents the facts and analytical conclusions on the results of the monitoring.

  6. Center Innovation Fund Program

    Data.gov (United States)

    National Aeronautics and Space Administration — To stimulate and encourage creativity and innovation within the NASA Centers. The activities are envisioned to fall within the scope of NASA Space Technology or...

  7. Center for Beam Physics, 1992

    International Nuclear Information System (INIS)

    This report contains the following information on the center for beam physics: Facilities; Organizational Chart; Roster; Profiles of Staff; Affiliates; Center Publications (1991--1993); and 1992 Summary of Activities

  8. Center for Beam Physics, 1992

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    This report contains the following information on the center for beam physics: Facilities; Organizational Chart; Roster; Profiles of Staff; Affiliates; Center Publications (1991--1993); and 1992 Summary of Activities.

  9. Italy INAF Data Center Report

    Science.gov (United States)

    Negusini, M.; Sarti, P.

    2013-01-01

    This report summarizes the activities of the Italian INAF VLBI Data Center. Our Data Center is located in Bologna, Italy and belongs to the Institute of Radioastronomy, which is part of the National Institute of Astrophysics.

  10. Functional Centering

    CERN Document Server

    Hahn, M

    1996-01-01

    Based on empirical evidence from a free word order language (German) we propose a fundamental revision of the principles guiding the ordering of discourse entities in the forward-looking centers within the centering model. We claim that grammatical role criteria should be replaced by indicators of the functional information structure of the utterances, i.e., the distinction between context-bound and unbound discourse elements. This claim is backed up by an empirical evaluation of functional centering.

  11. Multi-frequency EDMR studies of light-activated paramagnetic centers in μc-Si:H thin-film solar cells

    International Nuclear Information System (INIS)

    This thesis presents a comprehensive study of paramagnetic centers in fully-processed microcrystalline silicon (μc-Si:H) thin-film solar cells. The heterogeneous material gives rise to a complex band structure with deep defects in the middle of the energy band gap as well as localized states close to the energy band edges. They can act as recombination centers and traps and, thereby, influence the charge transport of photogenerated charge carriers. Thus, they diminish the performance of the cell. To reduce the disadvantageous influence of the defect states on the cell efficiency, a detailed understanding of the charge transport processes via these states is necessary. In this work, light-activated paramagnetic centers are studied with electrically detected magnetic resonance (EDMR) at various microwave frequencies. This technique combines electron paramagnetic resonance spectroscopy (EPR) with the photocurrent measurement in the solar cell, thus, delivering information about the transport processes and magnetic parameters of the involved defect states. Multi-frequency EDMR at low temperatures reveals four paramagnetic states in μc-Si:H. Dangling bond (db) defects and holes in valence band tail (h) states are located in the disordered phase, whereas so-called CE and V states originate from the crystalline phase. The multi-frequency approach allows for a separation of field-dependent and -independent line widths. All EDMR signals are affected by line broadening due to spin-spin interaction, which could be used to estimate mean inter-spin distances of around ∼ 0.5 nm for the V center and of ∼ 1-2 nm for the remaining centers. Based on the strong spin-spin coupling and on transient nutation experiments the V signal could be correlated with a vacancy site in its excited triplet state. From the particular properties of the CE line it was concluded that the corresponding states are located in inversion layers and potential wells close to the conduction band of

  12. Activities of the Radiation Shielding Information Center and a report on codes/data for high energy radiation transport

    International Nuclear Information System (INIS)

    From the very early days in its history Radiation Shielding Information Center (RSIC) has been involved with high energy radiation transport. The National Aeronautics and Space Administration was an early sponsor of RSIC until the completion of the Apollo Moon Exploration Program. In addition, the intranuclear cascade work of Bertini at Oak Ridge National Laboratory provided valuable resources which were made available through RSIC. Over the years, RSIC has had interactions with many of the developers of high energy radiation transport computing technology and data libraries and has been able to collect and disseminate this technology. The current status of this technology will be reviewed and prospects for new advancements will be examined

  13. A Longitudinal Study of Changes in Asylum Seekers Ability Regarding Activities of Daily Living During Their Stay in the Asylum Center

    DEFF Research Database (Denmark)

    Morville, Anne-Le; Amris, Kirstine; Eklund, Mona;

    2015-01-01

    The aim was to assess change in activities of daily living (ADL) ability amongst asylum seekers and if there were any difference between tortured and non-torture following a 10 months post-arrival period, and if self-reported health and exposure to torture were factors related to change in ADL...... participated. ADL-ability was measured using Assessment of Motor and Process Skills and questionnaires about exposure to torture, self-reported mental health and pain. ADL motor and process measures, well-being and self-rated health declined from baseline to follow-up. Measures of pain and depression increased......-ability. The study was a combined baseline, follow-up correlational study amongst individuals from Afghanistan, Iran and Syria, living in Danish asylum centers. Forty-three persons aged 20-50, were invited and participated in the baseline study. Twenty-two were still in asylum center at the follow-up and 17 of them...

  14. Distribution center

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    Distribution center is a logistics link fulfill physical distribution as its main functionGenerally speaking, it's a large and hiahly automated center destined to receive goods from various plants and suppliers,take orders,fill them efficiently,and deliver goods to customers as quickly as possible.

  15. Annual report of R and D activities in Center for Computational Science and e-Systems from April 1, 2007 to March 31, 2009

    International Nuclear Information System (INIS)

    This report provides an overview of research and development activities in Center for Computational Science and e-Systems (CCSE), JAEA, during the fiscal years 2007 and 2008 (Apr 1, 2007 - March 31, 2009). These research and development activities have been performed by the Simulation Technology R and D Office and Computer Science R and D Office. These activities include development of secure computational infrastructure for atomic energy research based on the grid technology, large scale seismic analysis of an entire nuclear reactor structure, large scale fluid dynamics simulation of J-PARC mercury target, large scale plasma simulation for nuclear fusion reactor, large scale atomic and subatomic simulations of nuclear fuels and materials for safety assessment, large scale quantum simulations of superconductor for the design of new devices and fundamental understanding of superconductivity, development of protein database for the identification of radiation-resistance gene, and large scale atomic simulation of proteins. (author)

  16. Activities 2009-2011 at the Atomic Spectroscopy Data Center at the National Institute of Standards and Technology (NIST)

    International Nuclear Information System (INIS)

    The work of the Atomic Spectroscopy Data Center team at the National Institute of Standards and Technology (NIST) in Gaithersburg, MD USA centered in the last two years on two main subjects: First, the data center completed and issued a new, significantly improved version of its principal product, the Atomic Spectra Database (ASD Version 4.0 in September 2010, with an update 4.1.0 in May 2011). These versions contain new data for a good number of additional spectra as well as new, better quality and more extensive data replacing the earlier material. They are also for the first time completely integrated with the two NIST bibliographies on atomic energy levels and spectra, and on atomic transition probabilities. The sources of the material selected in ASD for the various spectra and transitions are identified there by their numbers in the respective bibliographies, so that the original papers can be directly accessed by users if they desire more background material. Secondly, new tabulations of atomic energy levels and wavelengths were completed for hydrogen and its isotopes (H, D, T), for argon (Ar II through Ar XVIII), cesium (Cs I through Cs LV), barium (Ba III through Ba LVI) and tungsten (W III through W LXXIV). Compilations of energy levels and spectral lines are in progress on neon (Ne IV), chlorine (Cl I through Cl XVII), and nickel (Ni I through Ni VIII). Data assessments and compilations of atomic transition probabilities were completed for hydrogen and its isotopes (H,D,T), for helium(He I and He II), for lithium (Li I through Li III), beryllium (Be I through Be IV), boron (B I through B V), sulfur (S I through S XVI), cesium (Cs I through Cs LV), and barium (Ba III through Ba LVI). Additional compilations for the higher fluorine and neon ions (F V through F IX, Ne VI through Ne X), chlorine (Cl I through Cl XVII) and nickel (Ni I through Ni VIII) are in progress. As in all our earlier work, the NIST data tables are limited to reference data, i.e. data

  17. 物流中心作业成本通用模型研究%General Activity-based Cost Model for Logistics Center

    Institute of Scientific and Technical Information of China (English)

    朱燕春; 李洋

    2012-01-01

    为了实现流通企业物流中心的精细化成本管理,在分析作业成本法原理的基础上,结合流通企业物流中心的业务流程及其生产成本构成特点,本文构建了物流中心作业成本通用模型,并对通用模型中资源池的建立、作业池模型设计、确认成本核算对象、成本动因模型设计四大主要环节的成本核算过程和方法进行了研究和阐述,最后通过实例说明了作业成本法的应用.%In order to realize fine cost accounting and management in logistic center of circulation enterprise, with the analysis of the basic principles of Activity-based Costing as well as the combination of the operation process of the logistic center and the characteristics of its cost structure, this paper constructs a general model for the activity-based costs of logistic center, in this model, we will study and elaborate the process and method of cost accounting which consists of four links of the establishment of resource pool, the designing of activity pool model, the confirmation of cost accounting object and the designing of cost driver model and finally exemplify the application of ABC.

  18. Binding stability of peptides derived from 1ALA residue and 7GLY residues to sites near active center of fluctuating papain

    Science.gov (United States)

    Nishiyama, Katsuhiko

    2012-05-01

    We investigated the binding stability of peptides derived from 1ALA residue and 7GLY residues to sites near active center of fluctuating papain via molecular dynamics and docking simulations. Replacing GLY residue in 8GLY with ALA residue had a positive effect on binding stability to the sites in some cases although the replacing had a negative effect on it in other cases. Furthermore the replacing had a negative effect on the chance of binding to the sites. Residue in peptide should be replaced on the basis of systematic exploration of its position.

  19. Effects of Supported ( n BuCp) 2 ZrCl 2 Catalyst Active-Center Distribution on Ethylene–1-Hexene Copolymer Backbone Heterogeneity and Thermal Behaviors

    KAUST Repository

    Atiqullah, Muhammad

    2013-07-10

    Two catalysts, denoted as catalyst 1 [silica/MAO/(nBuCp) 2ZrCl2] and catalyst 2 [silica/nBuSnCl 3/MAO/(nBuCp)2ZrCl2] were synthesized and subsequently used to prepare, without separate feeding of methylaluminoxane (MAO), ethylene homopolymer 1 and homopolymer 2, respectively, and ethylene-1-hexene copolymer 1 and copolymer 2, respectively. Gel permeation chromatography (GPC), Crystaf, differential scanning calorimetry (DSC) [conventional and successive self-nucleation and annealing (SSA)], and 13C nuclear magnetic resonance (NMR) polymer characterization results were used, as appropriate, to model the catalyst active-center distribution, ethylene sequence (equilibrium crystal) distribution, and lamellar thickness distribution (both continuous and discrete). Five different types of active centers were predicted in each catalyst, as corroborated by the SSA experiments and complemented by an extended X-ray absorption fine structure (EXAFS) report published in the literature. 13C NMR spectroscopy also supported this active-center multiplicity. Models combined with experiments effectively illustrated how and why the active-center distribution and the variance in the design of the supported MAO anion, having different electronic and steric effects and coordination environments, influence the concerned copolymerization mechanism and polymer properties, including inter- and intrachain compositional heterogeneity and thermal behaviors. Copolymerization occurred according to the first-order Markovian terminal model, producing fairly random copolymers with minor skewedness toward blocky character. For each copolymer, the theoretical most probable ethylene sequences, nE MPDSC-GT and n E MPNMR-Flory, as well as the weight-average lamellar thicknesses, Lwav DSC-GT and Lwav SSA DSC, were found to be comparable. To the best of our knowledge, such a match has not previously been reported. The percentage crystallinities of the homo- and copolymers increased linearly as a function of

  20. Using fMRI to Detect Activation of the Cortical and Subcortical Auditory Centers: Development of a Standard Protocol for a Conventional 1.5-T MRI Scanner

    Energy Technology Data Exchange (ETDEWEB)

    Tae, Woo Suk; Kim, Sam Soo; Lee, Kang Uk; Lee, Seung Hwan; Nam, Eui Cheol [Kangwon National University School of Medicine, Chuncheon (Korea, Republic of); Choi, Hyun Kyung [Kangwon National University Hospital, Chuncheon (Korea, Republic of)

    2009-11-15

    We wanted to develop a standard protocol for auditory functional magnetic resonance imaging (fMRI) for detecting blood oxygenation level-dependent (BOLD) responses at the cortical and subcortical auditory centers with using a 1.5-T MRI scanner. Fourteen normal volunteers were enrolled in the study. The subjects were stimulated by four repetitions of 32 sec each with broadband white noise and silent period blocks as a run (34 echo planar images [EPIs]). Multiple regression analysis for the individual analysis and one-sample t-tests for the group analysis were applied (FDR, p <0.05). The auditory cortex was activated in most of the volunteers (left 100% and right 92.9% at an uncorrected p value <0.05, and left 92.9% and right 92.9% at an uncorreced p value <0.01). The cochlear nuclei (100%, 85.7%), inferior colliculi (71.4%, 64.3%), medial geniculate bodies (64.3%, 35.7%) and superior olivary complexes (35.7%, 35.7%) showed significant BOLD responses at uncorrected p values of <0.05 and p <0.01, respectively. On the group analysis, the cortical and subcortical auditory centers showed significant BOLD responses (FDR, p <0.05), except for the superior olivary complex. The signal intensity time courses of the auditory centers showed biphasic wave forms. We successfully visualized BOLD responses at the cortical and subcortical auditory centers using appropriate sound stimuli and an image acquisition method with a 1.5-T MRI scanner.

  1. Evaluation of macrophage activation syndrome associated with systemic juvenile idiopathic arthritis: single center experience over a one-year period

    Science.gov (United States)

    Barut, Kenan; Yücel, Gözde; Sinoplu, Ada Bulut; Şahin, Sezgin; Adroviç, Amra; Kasapçopur, Özgür

    2015-01-01

    Aim: This study aimed to evaluate the demographic, clinical, laboratory properties of patients with macrophage activation syndrome and treatment outcomes. Material and Methods: The data of the patients who were diagnosed with macrophage activation syndrome secondary to systemic juvenile idiopathic arthritis between June 2013–May 2014 were evaluated by screening patient records. Results: Ten patients with macrophage activation syndrome were followed up in one year. The mean age at the time of diagnosis was found to be 7.6±4.5 years. The most common clinical finding at presentation (80%) was increased body temperature. Hepatosplenomegaly was found in half of the patients. The most common hematological finding (90%) was anemia. The mean erythrocyte sedimentation rate was found to be 71.8±36.2 mm/h, whereas it was measured to be lower (31.2±25.2 mm/h) at the time of the diagnosis of macrophage activation syndrome. Increased ferritin level was found in all of our patients (the mean ferritin level was found to be 23 957±15 525 ng/mL). Hypertriglyceridemia was found in nine patients (90%). The mean triglyceride level was found to be 397±332 mg/dL. Systemic steroid treatment was administered to all patients. Cyclosporine A was given to eight patients (80%), canakinumab was given to four patients (40%) and anakinra was given to five patients (50%). Plasmapheresis was performed in two patients. Improvement was found in all patients except for one patient. The patient in whom no improvement was observed showed a chronic course. Conclusions: The diagnosis of macrophage activation syndrome should be considered in presence of sudden disturbance in general condition, resistant high fever and systemic inflammation findings in children with active rheumatic disease. Complete recovery can be provided with early and efficient treatment in macrophage activation syndrome which develops secondary to systemic juvenil idiopathic arthritis. PMID:26884689

  2. Antimicrobial activity of tigecycline against community-acquired methicillin-resistant Staphylococcus aureus isolates recovered from North American medical centers.

    Science.gov (United States)

    Mendes, Rodrigo E; Sader, Helio S; Deshpande, Lalitagauri; Jones, Ronald N

    2008-04-01

    A total of 1989 community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) were susceptibility tested by broth microdilution. Pulsed-field gel electrophoresis, SCCmec type, and polymerase chain reaction for Panton-Valentine leukocidin (PVL) genes were also performed. The overall tigecycline susceptibility rate was 98.2%. Glycopeptides, quinupristin/dalfopristin, linezolid, and chloramphenicol were also active against this collection (< or =0.7% resistant). The vast majority (70.8%) of the CA-MRSA was SCCmec type IV, from which 88.4% belonged to the USA300-0114 clone and 94.7% were PVL positive. Tigecycline showed in vitro activity comparable with other highly active parenteral agents and represents an option for treating complicated infections caused by CA-MRSA. PMID:18068326

  3. Distribution of histaminergic neurons and their modulatory effects on oscillatory activity in the olfactory center of the terrestrial slug Limax.

    Science.gov (United States)

    Matsuo, Ryota; Fukata, Rena; Kumagai, Moeko; Kobayashi, Asuka; Kobayashi, Suguru; Matsuo, Yuko

    2016-01-01

    Terrestrial mollusks can form an odor aversion memory following the simultaneous presentation of a food odor and an aversive stimulus. The local field potential oscillation recorded on the surface of the procerebrum (PC; the higher olfactory center) exhibits a frequency change in response to the detection of a learned odor; such a change is thus considered to reflect the internal state of the brain during memory recall. Thus far, dopamine and serotonin have been demonstrated to change the oscillatory frequency. Other monoamines, however, have not yet been studied. In the present study, we investigated the possible involvement of histamine (HA). Immunohistochemical staining of HA and in situ hybridization against histidine decarboxylase revealed the location of the cell bodies of HAergic neurons in all ganglia of the brain. The majority of them were located at the medial aspect of the pedal ganglia, and the cerebral ganglia also contained numerous HAergic neurons in their posterior regions. The neuropil layers of the PC received HAergic innervation from the neurons in the cerebral ganglion, as well as from a few neurons located in the dorsomedial part of the cell mass layer of the PC. The HAergic fibers, however, innervated spatially limited regions of the PC, and seemed to affect a small fraction of the PC neurons. HA exerted accelerating effects on the LFP oscillation in a dose-dependent manner, and this effect was suppressed by an H2 blocker, cimetidine. Our results support the involvement of HA in the functioning of the PC. PMID:26105566

  4. Organisational structure and its effect on the therapeutic activity and effectiveness in an american mental health center.

    Science.gov (United States)

    Andersen, T

    1975-01-01

    The mental health center movement represents a new mode of care for the mentally ill. People are treated on an out-patient basis rather than in institutions. The therapeutic work is mainly carried out by so-called paraprofessionals who seem to be well qualified for the job. However, when organizing such a treatment system there appear to be several important factors which need to be taken into account: (1) the therapist's need to work individually and independently, (2) the therapist's need for personal training, (3) the therapist's need to be heard when they channel information from the community to the service system, (4) the need for open and direct communication in the system to ensure that the therapists work within the frame of accepted therapeutic procedures, (5) the importance of the therapists' being represented at the highest decision-making level in the system in order to ensure that their needs are met. The author stresses this as an inevitable necessitiy in order to give the therapists the appropriate working-background.

  5. Antenna Technology and other Radio Frequency (RF) Communications Activities at the Glenn Research Center in Support of NASA's Exploration Vision

    Science.gov (United States)

    Miranda, Felix A.

    2007-01-01

    NASA s Vision for Space Exploration outlines a very ambitious program for the next several decades of the Space Agency endeavors. Ahead is the completion of the International Space Station (ISS); safely flight the shuttle (STS) until 2010; develop and fly the Crew Exploration Vehicle (Orion) by no later than 2014; return to the moon by no later than 2020; extend human presence across the solar system and beyond; implement a sustainable and affordable human and robotic program; develop supporting innovative technologies, knowledge and infrastructure; and promote international and commercial participation in exploration. To achieve these goals, a series of enabling technologies must be developed or matured in a timely manner. Some of these technologies are: spacecraft RF technology (e.g., high power sources and large antennas which using surface receive arrays can get up to 1 Gbps from Mars), uplink arraying (reduce reliance on large ground-based antennas and high operation costs; single point of failure; enable greater data-rates or greater effective distance; scalable, evolvable, flexible scheduling), software define radio (i.e., reconfigurable, flexible interoperability allows for in flight updates open architecture; reduces mass, power, volume), and optical communications (high capacity communications with low mass/power required; significantly increases data rates for deep space). This presentation will discuss some of the work being performed at the NASA Glenn Research Center, Cleveland, Ohio, in antenna technology as well as other on-going RF communications efforts.

  6. Senior Centers

    Medline Plus

    Full Text Available ... Living independently at home is something many older adults would like to do as long as they can. Senior centers, adult day care, transportation, and meals programs are long- ...

  7. Senior Centers

    Medline Plus

    Full Text Available ... transportation, and meals programs are long-term care services available in the community which make it easier ... about senior centers and other long-term care services available in your community, contact the Eldercare Locator ...

  8. Senior Centers

    Medline Plus

    Full Text Available ... of games. [Narrator] Many senior centers also offer exercise programs. [Karen Albers] We offer aerobics, tai chi, ... chi, tap dancing, ballroom dancing, square dancing, chair exercise, arthritis classes, yoga, and lots of dancing. [Narrator] ...

  9. Radiopharmaceutical activities administered for diagnostic procedures in nuclear medicine in the first six months of the gamma camera use in the Clinical Center of Montenegro - Podgorica

    International Nuclear Information System (INIS)

    Nuclear medicine procedures have carried out in the Clinical Center of Montenegro - Podgorica since 2006 by the dual-headed SPECT and Digital gamma camera NUCLINE Spirit DH-V. In the first six months of the gamma camera use (from September 2006 to March 2007) examinations of skeleton, kidneys, thyroid and lung were performed. For diagnostic skeletal imaging (102 patients) the radiopharmaceutical 99mTc-MDP is used, and administered activities were in the range from 555 to 740 MBq. For thyroid imaging (203 patients) 99mTc-pertechnetate is used, and administered activities were in the range (37-111) MBq. Lung imaging is performed for 3 patients, using 99mTc-MAA and administered activities in the range (111-185) MBq. Renal imaging is carried out for 72 patients: 42 dynamic studies of kidneys were performed with 99mTc-DTPA and administered activities from 207 to 282 MBq, and 30 static kidneys scintigraphies were performed using the radiopharmaceutical 99mTc-DMSA. 6 patients in the last mentioned group were children with year of birth between 2000 and 2006, and administered activities were from 16.6 to 55.5 MBq. In the same group, activities 28.5 MBq, 74.4 MBq and 120 MBq were administered to three patients with age between 6 and 18 years, and in the other cases, administered activities to the patients (adults) were in the range (59.2 to 196) MBq. The administered activities presented here are basis for further estimations of cumulated activity and absorbed dose to the various organs, which is useful for comparison of the average dose to patient organs in various nuclear medicine procedures and calculation of effective dose equivalent and total effective dose, significant for an estimation of potential risk due to the radioactivity administered to a patient during nuclear medicine procedures. It is very important for procedures optimization and improvement of the radiation protection. (author)

  10. Effects of a humor-centered activity on disruptive behavior in patients in a general hospital psychiatric ward

    OpenAIRE

    Higueras, Antonio; Carretero-Dios, Hugo; Mu??oz, Jos?? P.; Idini, Esther; Ortiz, Ana; Rinc??n, Francisco; Prieto-Merino, David

    2006-01-01

    This study would not have been possible without the professional collaboration and enthusiasm of the Titiritas Clown group, who were the stars of the humor-based activities on the ward. We offer special thanks to the members of this group: Jos?? P??rez de la Blanca, Francisco Parera, and Fernando P??rez de la Blanca.

  11. Screening of antimutagenicity via antioxidant activity in different extracts from the leaves of Acacia salicina from the center of Tunisia.

    Science.gov (United States)

    Bouhlel, Ines; Mansour, Hedi Ben; Limem, Ilef; Sghaier, Mohamed Ben; Mahmoud, Amor; Chibani, Jemni Ben; Ghedira, Kamel; Chekir-Ghedira, Leila

    2007-01-01

    The effect of extracts obtained from Acacia salicina on genotoxicity and SOS response induced by Benzo(a)pyrene (B[a]P) as well as nifuroxazide was investigated in a bacterial assay system, i.e., the SOS chromotest with Escherichia coli PQ37. Preparations obtained from the leaves of A. salicina exhibited no genotoxicity either with or without the external S9 activation mixture. However, all extracts significantly decreased the genotoxicity induced by (B[a]P) and nifuroxazide. Ethyl acetate, methanol and TOF extracts exhibited the highest inhibition level of the SOS response induced by the direct mutagen nifuroxazide. Whereas, aqueous, ethyl acetate and methanol extracts displayed the greatest level of protection towards the indirect mutagen, (B[a]P), induced response. In addition to their antigenotoxic activity, TOF, aqueous, methanol and chloroform extracts showed an important free radical scavenging activity towards the 1,1-diphenyl 2-picrylhydrazyl (DPPH) free radical. These extracts showed IC(50) value of 36, 73, 65, and 87μg/ml respectively. Taken together, our finding showed that A. salicina exhibits significant antioxidant and antigenotoxic activities. PMID:21783737

  12. 整合设计在少年活动中心中应用%The Application of Integrated Design in the Youth Activity Center

    Institute of Scientific and Technical Information of China (English)

    徐青; 金丽燕

    2014-01-01

    本文根据德令哈青少年活动中心的使用特点,结合当地的气候条件和地形地势,坚持“以人为本”的设计理念。通过整合设计方法,打造出一个多样、活泼的青少年活动空间。%This article bases on the functional characteristics of Delingha youth activity center, combines with the local cli-mate and terrain and topography to adhere the"people-oriente-d"design concept. The author bases on the method of integrat-ed design to create a diverse and lively youth activity space.

  13. Annual report of R and D activities in Center for Computational Science and e-Systems from April 1, 2009 to March 31, 2010

    International Nuclear Information System (INIS)

    This report overviews the activity of research and development (R and D) in Center for Computational Science and e-Systems (CCSE) of the Japan Atomic Energy Agency (JAEA), during the fiscal year 2009 (April 1, 2009 - March 31, 2010). The work has been accomplished by the Simulation Technology R and D Office and Computer Science R and D Office in CCSE. The activity includes researches of secure computational infrastructure for the use in atomic energy research, which is based on the grid technology, a seismic response analysis for the structure of nuclear power plants, materials science, and quantum bioinformatics. The materials science research includes large scale atomic and subatomic simulations of nuclear fuels and materials for safety assessment, large scale quantum simulations of superconductor for the design of new devices and fundamental understanding of superconductivity. The quantum bioinformatics research focuses on the development of technology for large scale atomic simulations of proteins. (author)

  14. Body mass index, physical activity, and dietary behaviors among members of an urban community fitness center: a questionnaire survey

    Directory of Open Access Journals (Sweden)

    O'Neil Amy E

    2007-07-01

    Full Text Available Abstract Background Development of effective behavioral interventions to promote weight control and physical activity among diverse, underserved populations is a public health priority. Community focused wellness organizations, such as YMCAs, could provide a unique channel with which to reach such populations. This study assessed health behaviors and related characteristics of members of an urban YMCA facility. Methods We surveyed 135 randomly selected members of an urban YMCA facility in Massachusetts to examine self-reported (1 physical activity, (2 dietary behaviors, (3 body mass index, and (4 correlates of behavior change among short-term (i.e., one year or less and long-term (i.e., more than one year members. Chi-square tests were used to assess bivariate associations between variables, and multivariate linear regression models were fit to examine correlates of health behaviors and weight status. Results Eighty-nine percent of short-term and 94% of long-term members reported meeting current physical activity recommendations. Only 24% of short-term and 19% of long-term members met fruit and vegetable consumption recommendations, however, and more than half were overweight or obese. Length of membership was not significantly related to weight status, dietary behaviors, or physical activity. Most respondents were interested in changing health behaviors, in the preparation stage of change, and had high levels of self-efficacy to change behaviors. Short-term members had less education (p = 0.02, lower household incomes (p = 0.02, and were less likely to identify as white (p = 0.005 than long-term members. In multivariate models, females had lower BMI than males (p = 0.003 and reported less physical activity (p = 0.008. Physical activity was also inversely associated with age (p = 0.0004 and education (p = 0.02. Conclusion Rates of overweight/obesity and fruit and vegetable consumption suggested that there is a need for a weight control

  15. Crystal structure of Helicobacter pylori neutrophil-activating protein with a di-nuclear ferroxidase center in a zinc or cadmium-bound form

    Energy Technology Data Exchange (ETDEWEB)

    Yokoyama, Hideshi, E-mail: h-yokoya@u-shizuoka-ken.ac.jp [School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526 (Japan); Tsuruta, Osamu; Akao, Naoya; Fujii, Satoshi [School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526 (Japan)

    2012-06-15

    Highlights: Black-Right-Pointing-Pointer Structures of a metal-bound Helicobacter pylori neutrophil-activating protein were determined. Black-Right-Pointing-Pointer Two zinc ions were tetrahedrally coordinated by ferroxidase center (FOC) residues. Black-Right-Pointing-Pointer Two cadmium ions were coordinated in a trigonal-bipyramidal and octahedral manner. Black-Right-Pointing-Pointer The second metal ion was more weakly coordinated than the first at the FOC. Black-Right-Pointing-Pointer A zinc ion was found in one negatively-charged pore suitable as an ion path. -- Abstract: Helicobacter pylori neutrophil-activating protein (HP-NAP) is a Dps-like iron storage protein forming a dodecameric shell, and promotes adhesion of neutrophils to endothelial cells. The crystal structure of HP-NAP in a Zn{sup 2+}- or Cd{sup 2+}-bound form reveals the binding of two zinc or two cadmium ions and their bridged water molecule at the ferroxidase center (FOC). The two zinc ions are coordinated in a tetrahedral manner to the conserved residues among HP-NAP and Dps proteins. The two cadmium ions are coordinated in a trigonal-bipyramidal and distorted octahedral manner. In both structures, the second ion is more weakly coordinated than the first. Another zinc ion is found inside of the negatively-charged threefold-related pore, which is suitable for metal ions to pass through.

  16. Analysis of Family Structures Reveals Robustness or Sensitivity of Bursting Activity to Parameter Variations in a Half-Center Oscillator (HCO) Model.

    Science.gov (United States)

    Doloc-Mihu, Anca; Calabrese, Ronald L

    2016-01-01

    The underlying mechanisms that support robustness in neuronal networks are as yet unknown. However, recent studies provide evidence that neuronal networks are robust to natural variations, modulation, and environmental perturbations of parameters, such as maximal conductances of intrinsic membrane and synaptic currents. Here we sought a method for assessing robustness, which might easily be applied to large brute-force databases of model instances. Starting with groups of instances with appropriate activity (e.g., tonic spiking), our method classifies instances into much smaller subgroups, called families, in which all members vary only by the one parameter that defines the family. By analyzing the structures of families, we developed measures of robustness for activity type. Then, we applied these measures to our previously developed model database, HCO-db, of a two-neuron half-center oscillator (HCO), a neuronal microcircuit from the leech heartbeat central pattern generator where the appropriate activity type is alternating bursting. In HCO-db, the maximal conductances of five intrinsic and two synaptic currents were varied over eight values (leak reversal potential also varied, five values). We focused on how variations of particular conductance parameters maintain normal alternating bursting activity while still allowing for functional modulation of period and spike frequency. We explored the trade-off between robustness of activity type and desirable change in activity characteristics when intrinsic conductances are altered and identified the hyperpolarization-activated (h) current as an ideal target for modulation. We also identified ensembles of model instances that closely approximate physiological activity and can be used in future modeling studies. PMID:27595135

  17. Analysis of Family Structures Reveals Robustness or Sensitivity of Bursting Activity to Parameter Variations in a Half-Center Oscillator (HCO) Model.

    Science.gov (United States)

    Doloc-Mihu, Anca; Calabrese, Ronald L

    2016-01-01

    The underlying mechanisms that support robustness in neuronal networks are as yet unknown. However, recent studies provide evidence that neuronal networks are robust to natural variations, modulation, and environmental perturbations of parameters, such as maximal conductances of intrinsic membrane and synaptic currents. Here we sought a method for assessing robustness, which might easily be applied to large brute-force databases of model instances. Starting with groups of instances with appropriate activity (e.g., tonic spiking), our method classifies instances into much smaller subgroups, called families, in which all members vary only by the one parameter that defines the family. By analyzing the structures of families, we developed measures of robustness for activity type. Then, we applied these measures to our previously developed model database, HCO-db, of a two-neuron half-center oscillator (HCO), a neuronal microcircuit from the leech heartbeat central pattern generator where the appropriate activity type is alternating bursting. In HCO-db, the maximal conductances of five intrinsic and two synaptic currents were varied over eight values (leak reversal potential also varied, five values). We focused on how variations of particular conductance parameters maintain normal alternating bursting activity while still allowing for functional modulation of period and spike frequency. We explored the trade-off between robustness of activity type and desirable change in activity characteristics when intrinsic conductances are altered and identified the hyperpolarization-activated (h) current as an ideal target for modulation. We also identified ensembles of model instances that closely approximate physiological activity and can be used in future modeling studies.

  18. Analysis of Family Structures Reveals Robustness or Sensitivity of Bursting Activity to Parameter Variations in a Half-Center Oscillator (HCO) Model

    Science.gov (United States)

    2016-01-01

    The underlying mechanisms that support robustness in neuronal networks are as yet unknown. However, recent studies provide evidence that neuronal networks are robust to natural variations, modulation, and environmental perturbations of parameters, such as maximal conductances of intrinsic membrane and synaptic currents. Here we sought a method for assessing robustness, which might easily be applied to large brute-force databases of model instances. Starting with groups of instances with appropriate activity (e.g., tonic spiking), our method classifies instances into much smaller subgroups, called families, in which all members vary only by the one parameter that defines the family. By analyzing the structures of families, we developed measures of robustness for activity type. Then, we applied these measures to our previously developed model database, HCO-db, of a two-neuron half-center oscillator (HCO), a neuronal microcircuit from the leech heartbeat central pattern generator where the appropriate activity type is alternating bursting. In HCO-db, the maximal conductances of five intrinsic and two synaptic currents were varied over eight values (leak reversal potential also varied, five values). We focused on how variations of particular conductance parameters maintain normal alternating bursting activity while still allowing for functional modulation of period and spike frequency. We explored the trade-off between robustness of activity type and desirable change in activity characteristics when intrinsic conductances are altered and identified the hyperpolarization-activated (h) current as an ideal target for modulation. We also identified ensembles of model instances that closely approximate physiological activity and can be used in future modeling studies. PMID:27595135

  19. Activation in brain energy regulation and reward centers by food cues varies with choice of visual stimulus

    OpenAIRE

    Schur, Ellen; Kleinhans, Natalia; Goldberg, Jack; Buchwald, Dedra; Schwartz, Michael; Maravilla, Ken

    2009-01-01

    Objective To develop a noninvasive method of studying brain mechanisms involved in energy homeostasis and appetite regulation in humans by using visual food cues that are relevant to individuals attempting weight loss. Design Functional magnetic resonance imaging (fMRI) was used to compare brain activation in regions of interest between groups of food photographs. Participants 10 healthy, nonobese women who were not dieting for weight loss. Measurements Independent raters viewed food photogra...

  20. A step towards realizing a pan-European Climate Service - Activities of the Climate Service Center in the ECLISE project

    Science.gov (United States)

    Weber, B.

    2012-04-01

    The overall objective of the EU funded project ECLISE (Enabling Climate Information Service for Europe) is to take the first step towards the realisation of a European Climate Service. The approach of this pan-European effort is to conduct 26 case studies in which researchers closely cooperate with users of climate information to develop and demonstrate local climate services to support climate adaption policies. ECLISE focuses on climate-vulnerable regions in Europe, and analyzes four sectoral levels: cities, water resources, coastal defence and energy production. The ECLISE approach covers all elements of flow of information including climate modelling, impact modelling and implementation of simulations into the decision making process on adaptation measures development. The Climate Service Center Germany (CSC) is one of 12 project partners and leads the work package integration and synthesis of project results. CSC contributes to the maintenance of dialogue between researchers and users and conducts climate simulation. One main task of CSC in ECLISE is to provide an outline and proof of concept for a pan-European Climate Service as a key outcome of the project. To reach this objective the first step is to provide an inventory of existing Climate Service initiatives around the globe. The ECLISE case study results will be analysed to investigate the functionality of local Climate Services within these demonstrations. In cooperation with other modelling groups CSC conducts climate simulations for whole Europe with a spatial resolution of 10 Km and for climate-vulnerable regions in particular with high spatial resolution (2-4 Km). These results will be implemented for further local impact and adaptation studies which will be done in close cooperation with local decision makers. The users of climate information in ECLISE are representatives from local and regional authorities, municipalities and decision makers from enterprises. In 2012 a broader set of European

  1. Acetylene hydratase: a non-redox enzyme with tungsten and iron-sulfur centers at the active site.

    Science.gov (United States)

    Kroneck, Peter M H

    2016-03-01

    In living systems, tungsten is exclusively found in microbial enzymes coordinated by the pyranopterin cofactor, with additional metal coordination provided by oxygen and/or sulfur, and/or selenium atoms in diverse arrangements. Prominent examples are formate dehydrogenase, formylmethanofuran dehydrogenase, and aldehyde oxidoreductase all of which catalyze redox reactions. The bacterial enzyme acetylene hydratase (AH) stands out of its class as it catalyzes the conversion of acetylene to acetaldehyde, clearly a non-redox reaction and a reaction distinct from the reduction of acetylene to ethylene by nitrogenase. AH harbors two pyranopterins bound to W, and a [4Fe-4S] cluster. W is coordinated by four dithiolene sulfur atoms, one cysteine sulfur, and one oxygen ligand. AH activity requires a strong reductant suggesting W(IV) as the active oxidation state. Two different types of reaction pathways have been proposed. The 1.26 Å structure reveals a water molecule coordinated to W which could gain a partially positive net charge by the adjacent protonated Asp-13, enabling a direct attack of C2H2. To access the W-Asp site, a substrate channel was evolved distant from where it is found in other members of the DMSOR family. Computational studies of this second shell mechanism led to unrealistically high energy barriers, and alternative pathways were proposed where C2H2 binds directly to W. The architecture of the catalytic cavity, the specificity for C2H2 and the results from site-directed mutagenesis do not support this first shell mechanism. More investigations including structural information on the binding of C2H2 are needed to present a conclusive answer. PMID:26790879

  2. Hampshire College Center for Science Education. Final Report on Activities Supported by the Department of Energy Grant No. DE-FG02-06ER64256

    Energy Technology Data Exchange (ETDEWEB)

    Stillings, Neil; Wenk, Laura

    2009-12-30

    Hampshire College's Center for Science Education (Center) focuses on teacher professional development, curriculum development, and student enrichment programs. The Center also maintains research programs on teacher change, student learning and instructional effectiveness. The Center's work promotes learning that persists over time and transfers to new situations in and out of school. The projects develop the implications of the increasing agreement among teachers and researchers that effective learning involves active concept mastery and consistent practice with inquiry and critical thinking. The Center's objective is to help strengthen the pipeline of U.S. students pursuing postsecondary study in STEM fields. The Center achieves this by fostering an educational environment in which science is taught as an active, directly experienced endeavor across the K-16 continuum. Too often, young people are dissuaded from pursuing science because they do not see its relevance, instead experiencing it as dry, rote, technical. In contrast, when science is taught as a hands-on, inquiry-driven process, students are encouraged to ask questions grounded in their own curiosity and seek experimental solutions accordingly. In this way, they quickly discover both the profound relevance of science to their daily lives and its accessibility to them. Essentially, they learn to think and act like real scientists. The Center’s approach is multi-faceted: it includes direct inquiry-based science instruction to secondary and postsecondary students, educating the next generation of teachers, and providing new educational opportunities for teachers already working in the schools. Funding from the Department of Energy focused on the last population, enabling in-service teachers to explore and experience the pedagogy of inquiry-based science for themselves, and to take it back to their classrooms and students. The Center has demonstrated that the inquiry-based approach to science

  3. Lens auto-centering

    Science.gov (United States)

    Lamontagne, Frédéric; Desnoyers, Nichola; Doucet, Michel; Côté, Patrice; Gauvin, Jonny; Anctil, Geneviève; Tremblay, Mathieu

    2015-09-01

    In a typical optical system, optical elements usually need to be precisely positioned and aligned to perform the correct optical function. This positioning and alignment involves securing the optical element in a holder or mount. Proper centering of an optical element with respect to the holder is a delicate operation that generally requires tight manufacturing tolerances or active alignment, resulting in costly optical assemblies. To optimize optical performance and minimize manufacturing cost, there is a need for a lens mounting method that could relax manufacturing tolerance, reduce assembly time and provide high centering accuracy. This paper presents a patent pending lens mounting method developed at INO that can be compared to the drop-in technique for its simplicity while providing the level of accuracy close to that achievable with techniques using a centering machine (usually innovative auto-centering method is based on the use of geometrical relationship between the lens diameter, the lens radius of curvature and the thread angle of the retaining ring. The autocentering principle and centering test results performed on real optical assemblies are presented. In addition to the low assembly time, high centering accuracy, and environmental robustness, the INO auto-centering method has the advantage of relaxing lens and barrel bore diameter tolerances as well as lens wedge tolerances. The use of this novel lens mounting method significantly reduces manufacturing and assembly costs for high performance optical systems. Large volume productions would especially benefit from this advancement in precision lens mounting, potentially providing a drastic cost reduction.

  4. Fusion engineering design center

    International Nuclear Information System (INIS)

    In the spring of 1985, the Department of Energy (DOE) directed the Design Center to take a lead responsibility in assessing the engineering feasibility of a very compact tokamak experiment with copper coils. Following this assessment, the Design Center studied the Ignitor concept at the request of DOE and arrived at a design configuration. Many features of this configuration have been incorporated into the national baseline conceptual design for a Compact Ignition Tokamak (CIT). The Design Center continued to participate in the mirror program by contributing to the Minimars design effort, a two-year program to develop and describe an attractive tandem mirror reactor concept. The Design Center's principal role is in configuration definition of the candidate concepts. The Design Center continues to lead the engineering activities for the International Tokamak Reactor program. Advanced commercial tokamaks were studied by the Design Center as part of the Tokamak Power Systems Studies project coordinated by the DOE Office of Fusion Energy. The Design Center also provided design integration of the US effort. A cost accounting system that is applicable to all magnetic fusion reactor design studies was developed and applied to different confinement concepts and types of projects. The system provides the structure for development of a fusion cost database and validated cost estimating procedures

  5. Integrated real-time information to use in commercial, logistics and operational activities provide by the national control center operation of Transpetro

    Energy Technology Data Exchange (ETDEWEB)

    Aniceto, Hello A. R. [National Control Center Operation Transpetro, Rio de Janeiro, (Brazil)

    2010-07-01

    TRANSPETRO needed real time computational tools to manage its commercial, logistics and operational activities more efficiently. TRANSPETRO's National Control Center Operation developed an information site that provides information in real time on the process plans involved in each operation, using a Plant Information Management System (PIMS). SCADA systems were introduced during 2009 and 2010. This paper reports on the global introduction of the site and its basic architecture. Every screen displays the overall data in real time on movement in volume in pipeline operated by TRANSPETRO. The products transported are tracked for each infrastructure and are shown on dynamic geographic maps. Applications have been developed to improve the quality of information available to customers. It was found that the development of this site using PIMS technology brought gains in support to decision-making at the strategic and tactical levels for TRANSPETRO.

  6. Drought Management Activities of the National Drought Mitigation Center (NDMC): Contributions Toward a Global Drought Early Warning System (GDEWS)

    Science.gov (United States)

    Stumpf, A.; Lachiche, N.; Malet, J.; Kerle, N.; Puissant, A.

    2011-12-01

    VHR satellite images have become a primary source for landslide inventory mapping after major triggering events such as earthquakes and heavy rainfalls. Visual image interpretation is still the prevailing standard method for operational purposes but is time-consuming and not well suited to fully exploit the increasingly better supply of remote sensing data. Recent studies have addressed the development of more automated image analysis workflows for landslide inventory mapping. In particular object-oriented approaches that account for spatial and textural image information have been demonstrated to be more adequate than pixel-based classification but manually elaborated rule-based classifiers are difficult to adapt under changing scene characteristics. Machine learning algorithm allow learning classification rules for complex image patterns from labelled examples and can be adapted straightforwardly with available training data. In order to reduce the amount of costly training data active learning (AL) has evolved as a key concept to guide the sampling for many applications. The underlying idea of AL is to initialize a machine learning model with a small training set, and to subsequently exploit the model state and data structure to iteratively select the most valuable samples that should be labelled by the user. With relatively few queries and labelled samples, an AL strategy yields higher accuracies than an equivalent classifier trained with many randomly selected samples. This study addressed the development of an AL method for landslide mapping from VHR remote sensing images with special consideration of the spatial distribution of the samples. Our approach [1] is based on the Random Forest algorithm and considers the classifier uncertainty as well as the variance of potential sampling regions to guide the user towards the most valuable sampling areas. The algorithm explicitly searches for compact regions and thereby avoids a spatially disperse sampling pattern

  7. Self-assembly of cobalt-centered metal organic framework and multiwalled carbon nanotubes hybrids as a highly active and corrosion-resistant bifunctional oxygen catalyst

    Science.gov (United States)

    Fang, Yiyun; Li, Xinzhe; Li, Feng; Lin, Xiaoqing; Tian, Min; Long, Xuefeng; An, Xingcai; Fu, Yan; Jin, Jun; Ma, Jiantai

    2016-09-01

    Metal organic frameworks (MOF) derived carbonaceous materials have emerged as promising bifunctional oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) catalysts for electrochemical energy conversion and storage. But previous attempts to overcome the poor electrical conductivity of MOFs hybrids involve a harsh high-template pyrolytic process to in situ form carbon, which suffer from extremely complex operation and inevitable carbon corrosion at high positive potentials when OER is operated. Herein, a self-assembly approach is presented to synthesize a non-precious metal-based, high active and strong durable Co-MOF@CNTs bifunctional catalyst for OER and ORR. CNTs not only improve the transportation of the electrons but also can sustain the harsh oxidative environment of OER without carbon corrosion. Meanwhile, the unique 3D hierarchical structure offers a large surface area and stable anchoring sites for active centers and CNTs, which enables the superior durability of hybrid. Moreover, a synergistic catalysis of Co(II), organic ligands and CNTs will enhance the bifunctional electrocatalytic performance. Impressively, the hybrid exhibits comparable OER and ORR catalytic activity to RuO2 and 20 wt% Pt/C catalysts and superior stability. This facile and versatile strategy to fabricating MOF-based hybrids may be extended to other electrode materials for fuel cell and water splitting applications.

  8. Evaluation of 2,4-D removal via activated carbon from pomegranate husk/polymer composite hydrogel: Optimization of process parameters through face centered composite design

    Energy Technology Data Exchange (ETDEWEB)

    Taktak, Fulya; Ilbay, Zeynep [Usak Univ, Usak (Turkmenistan); Sahin, Selin [Istanbul University, Istanbul (Turkmenistan)

    2015-09-15

    A new type of polymer composite hydrogel was prepared by introducing activated carbons from pomegranate husk into poly ((2-dimethylamino) ethyl methacrylate) network. The removal of 2,4-dichlorophenoxyacetic acid (2,4-D) from aqueous solution was studied with respect to pH of the media, initial 2,4-D concentration and activated carbon content into the polymeric network. Face centered composite design (FCCD) through response surface methodology (RSM) was used for designing the experiments as well as for studying the effects of the process parameters. A quadratic model and a two factor interaction design model were developed for the removal of 2,4-D and adsorption capacity, respectively. The optimum pH of the pesticide solution, activated carbon content into the polymeric network and initial concentration of 2,4-D were found as 3, 2.5 wt% and 100mg/L. 63.245% and 68.805 (mg/g) for the removal of 2,4-D and adsorption capacity were obtained by using Simplex optimization method. Furthermore, the surface characteristics of the adsorbent prepared under optimized conditions were examined by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR).

  9. Attivita del Centro di Linguistica Applicata nel campo della lingua e della cultura italiana all'estero (Activities of the Italian Center for Applied Linguistics concerning Italian Language and Culture Abroad).

    Science.gov (United States)

    Boriosi Katerinov, Maria Clotilde

    1979-01-01

    Outlines the activities of a recently created section of the Italian Center for Applied Linguistics (CILA), dealing with "Teaching Italian Abroad." Describes these activities as encompassing four areas: research, teaching methodology, consultation, teachers' training and bibliographical information. Lists statistical surveys, research papers, and…

  10. Status of Activities on Rehabilitation Of Radioactively Contaminated Facilities and the Site of Russian Research Center ''Kurchatov Institute''

    Energy Technology Data Exchange (ETDEWEB)

    Volkov, V. G.; Ponomarev-Stepnoi, N. N.; Melkov, E. S; Ryazantsev, E. P.; Dikarev, V. S.; Gorodetsky, G. G.; Zverkov, Yu. A.; Kuznetsov, V. V.; Kuznetsova, T. I.

    2003-02-25

    This paper describes the program, the status, and the course of activities on rehabilitation of radioactively contaminated facilities and the territory of temporary radioactive waste (radwaste) disposal at the Russian Research Center ''Kurchatov Institute'' (RRC KI) in Moscow as performed in 2001-2002. The accumulation of significant amounts of radwaste at RRC KI territory is shown to be the inevitable result of Institute's activity performed in the days of former USSR nuclear weapons project and multiple initial nuclear power projects (performed from 1950's to early 1970's). A characterization of RRC KI temporary radwaste disposal site is given. Described is the system of radiation control and monitoring as implemented on this site. A potential hazard of adverse impacts on the environment and population of the nearby housing area is noted, which is due to possible spread of the radioactive plume by subsoil waters. A description of the concept and project of the RRC KI temporary radwaste disposal site is presented. Specific nature of the activities planned and performed stems from the nearness of housing area. This paper describes main stages of the planned activities for rehabilitation, their expected terms and sources of funding, as well as current status of the project advancement. Outlined are the problems faced in the performance and planning of works. The latter include: diagnostics of the concrete-grouted repositories, dust-suppression technologies, packaging of the fragmented ILW and HLW, soil clean-up, radioactive plume spread prevention, broad radiation monitoring of the work zone and environment in the performance of rehabilitation works. Noted is the intention of RRC KI to establish cooperation with foreign, first of all, the U.S. partners for the solution of problems mentioned above.

  11. Living Together in Space: The International Space Station Internal Active Thermal Control System Issues and Solutions-Sustaining Engineering Activities at the Marshall Space Flight Center From 1998 to 2005

    Science.gov (United States)

    Wieland, P. O.; Roman, M. C.; Miller, L.

    2007-01-01

    On board the International Space Station, heat generated by the crew and equipment is removed by the internal active thermal control system to maintain a comfortable working environment and prevent equipment overheating. Test facilities simulating the internal active thermal control system (IATCS) were constructed at the Marshall Space Flight Center as part of the sustaining engineering activities to address concerns related to operational issues, equipment capability, and reliability. A full-scale functional simulator of the Destiny lab module IATCS was constructed and activated prior to launch of Destiny in 2001. This facility simulates the flow and thermal characteristics of the flight system and has a similar control interface. A subscale simulator was built, and activated in 2000, with special attention to materials and proportions of wetted surfaces to address issues related to changes in fluid chemistry, material corrosion, and microbial activity. The flight issues that have arisen and the tests performed using the simulator facilities are discussed in detail. In addition, other test facilities at the MSFC have been used to perform specific tests related to IATCS issues. Future testing is discussed as well as potential modifications to the simulators to enhance their utility.

  12. Senior Centers

    Medline Plus

    Full Text Available ... Karen Albers] We provide a wide variety of activities -- physical, health, mental health programs with Senior Plus, cognitive programs, a wide variety of general activities, billiards, Bingo, lots of games. [Narrator] Many senior ...

  13. Prediction of attendance at fitness center: a comparison between theory of planned behavior, social cognitive theory, and physical activity maintenance theory

    Directory of Open Access Journals (Sweden)

    Darko eJekauc

    2015-02-01

    Full Text Available In the processes of physical activity (PA maintenance specific predictors are effective, which differ from other stages of PA development. Recently, Physical Activity Maintenance Theory (PAMT was specifically developed for prediction of PA maintenance. The aim of the present study was to evaluate the predictability of the future behavior by the PAMT and compare it with the Theory of Planned Behavior (TPB and Social Cognitive Theory (SCT. Participation rate in a fitness center was observed for 101 college students (53 female aged between 19 and 32 years (M = 23.6; SD = 2.9 over 20 weeks using a magnetic card. In order to predict the pattern of participation TPB, SCT and PAMT were used. A latent class zero-inflated Poisson growth curve analysis identified two participation patterns: regular attenders and intermittent exercisers. SCT showed the highest predictive power followed by PAMT and TPB. Impeding aspects as life stress and barriers were the strongest predictors suggesting that overcoming barriers might be an important aspect for exercise maintenance. Self-efficacy, perceived behavioral control, and social support could also significantly differentiate between the participation patterns.

  14. Prediction of attendance at fitness center: a comparison between the theory of planned behavior, the social cognitive theory, and the physical activity maintenance theory.

    Science.gov (United States)

    Jekauc, Darko; Völkle, Manuel; Wagner, Matthias O; Mess, Filip; Reiner, Miriam; Renner, Britta

    2015-01-01

    In the processes of physical activity (PA) maintenance specific predictors are effective, which differ from other stages of PA development. Recently, Physical Activity Maintenance Theory (PAMT) was specifically developed for prediction of PA maintenance. The aim of the present study was to evaluate the predictability of the future behavior by the PAMT and compare it with the Theory of Planned Behavior (TPB) and Social Cognitive Theory (SCT). Participation rate in a fitness center was observed for 101 college students (53 female) aged between 19 and 32 years (M = 23.6; SD = 2.9) over 20 weeks using a magnetic card. In order to predict the pattern of participation TPB, SCT and PAMT were used. A latent class zero-inflated Poisson growth curve analysis identified two participation patterns: regular attenders and intermittent exercisers. SCT showed the highest predictive power followed by PAMT and TPB. Impeding aspects as life stress and barriers were the strongest predictors suggesting that overcoming barriers might be an important aspect for working out on a regular basis. Self-efficacy, perceived behavioral control, and social support could also significantly differentiate between the participation patterns.

  15. Effects of electric stimulation of the hunger center in the lateral hypothalamus on slow electric activity and spike activity of fundal and antral stomach muscles in rabbits under conditions of hunger and satiation.

    Science.gov (United States)

    Kromin, A A; Zenina, O Yu

    2013-09-01

    In chronic experiments on rabbits, the effect of electric stimulation of the hunger center in the lateral hypothalamus on myoelectric activity of the fundal and antral parts of the stomach was studied under conditions of hunger and satiation in the absence of food. Stimulation of the lateral hypothalamus in rabbits subjected to 24-h food deprivation and in previously fed rabbits produced incessant seeking behavior, which was followed by reorganization of the structure of temporal organization of slow wave electric activity of muscles of the stomach body and antrum specific for hungry and satiated animals. Increased hunger motivation during electric stimulation of the lateral hypothalamus manifested in the structure of temporal organization of slow wave electric activity of the stomach body and antrum muscles in rabbits subjected to 24-h food deprivation in the replacement of bimodal distribution of slow wave periods to a trimodal type typical of 2-day deprivation, while transition from satiation to hunger caused by electric stimulation of the lateral hypothalamus was associated with a shift from monomodal distributions of slow wave periods to a bimodal type typical of 24-h deprivation. Reorganization of the structure of temporal organization of slow wave electric activity of the stomach body and antrum muscles during electric stimulation of the lateral hypothalamus was determined by descending inhibitory influences of food motivational excitation on activity of the myogenic pacemaker of the lesser curvature of the stomach.

  16. Impact of the marketing activities related to service offer an the Nuclear Information Center of the brazilian National Nuclear Energy Commission

    International Nuclear Information System (INIS)

    Exploratory field research confirms the marketing administration philosophy in Nuclear Information Center (CIN) of National Commission of Nuclear Energy (CNEN), analyzing marketing activities referring to SONAR-INIS (current awareness) and SERVIR-INIS (provision of copies) promotion, in order to evaluate the impact of these activities relating to the use of the services by real users. The data collecting took place using a technique of documental analysis, semi-structured interviews with five managers of the Center, simple no-participant observation accomplished by the researcher in CIN, questionnaires about the administration philosophy applied to the managers, and questionnaires sent by mail to 176 users of the international sample. The 122 users'answers (69,31% of answers rate) were analyzed according to the statistical procedures of Statistical Package of Social Sciences (SPSS), with 0,05% of error margin, and 95% of confidence level. Nine assumptions of research were tested. It was concluded that: the first knowledge of the services was by circulars or letters; SONAR-INIS was not considered as the principal service by its information contents in order to develop professional activities by 60,5% of the users; SERVIR-INIS was considered the main service to access the documents related to the interest of 47,8% of the user; to the majority the most important reason to use both services was the convenience and facilities to access the services; suitability of interest was the most important criterion in order to accomplish the appropriate service; the CIN inquiry frequency to know about users' satisfaction level, their information interests, needs and expectation in order to adapt information offer to demand was irregular and seldom; CIN's concerns about knowing users' critics, complaints and suggestions was recognized by users; the majority of the users was interested in receiving information about the benefits of the services; the price of the copies obtained in

  17. Communication between Thiamin Cofactors in the Escherichia coli Pyruvate Dehydrogenase Complex E1 Component Active Centers: EVIDENCE FOR A “DIRECT PATHWAY” BETWEEN THE 4′-AMINOPYRIMIDINE N1′ ATOMS*

    OpenAIRE

    Nemeria, Natalia S.; Arjunan, Palaniappa; Chandrasekhar, Krishnamoorthy; Mossad, Madouna; Tittmann, Kai; Furey, William; Jordan, Frank

    2010-01-01

    Kinetic, spectroscopic, and structural analysis tested the hypothesis that a chain of residues connecting the 4′-aminopyrimidine N1′ atoms of thiamin diphosphates (ThDPs) in the two active centers of the Escherichia coli pyruvate dehydrogenase complex E1 component provides a signal transduction pathway. Substitution of the three acidic residues (Glu571, Glu235, and Glu237) and Arg606 resulted in impaired binding of the second ThDP, once the first active center was filled, suggesting a pathway...

  18. Distributed H2 Supply for Fuel Cell Utility Vehicles Year 6 - Activity 3.5 - Development fo a National Center for Hydrogen Technology

    Energy Technology Data Exchange (ETDEWEB)

    Almlie, Jay

    2012-04-15

    The Energy & Environmental Research Center (EERC) has developed a high-pressure hydrogen production system that reforms a liquid organic feedstock and water at operating pressures up to 800 bar (~12,000 psig). The advantages of this system include the elimination of energy-intensive hydrogen compression, a smaller process footprint, and the elimination of gaseous or liquid hydrogen transport. This system could also potentially enable distributed hydrogen production from centralized coal. Processes have been investigated to gasify coal and then convert the syngas into alcohol or alkanes. These alcohols and alkanes could then be easily transported in bulk to distributed high-pressure water-reforming (HPWR)-based systems to deliver hydrogen economically. The intent of this activity was to utilize the EERC’s existing HPWR hydrogen production process, previously designed and constructed in a prior project phase, as a basis to improve operational and production performance of an existing demonstration unit. Parameters to be pursued included higher hydrogen delivery pressure, higher hydrogen production rates, and the ability to refill within a 5-minute time frame.

  19. Phosphoenolpyruvate-dependent protein kinase enzyme I of Streptococcus faecalis: purification and properties of the enzyme and characterization of its active center

    International Nuclear Information System (INIS)

    Enzyme I, the phosphoenolpyruvate:protein phosphotransferase (EC 2.7.3.9), which is part of the bacterial phosphoenolpyruvate-(PEP) dependent phosphotransferase system, has been purified from Streptococcus faecalis by using a large-scale preparation. Size exclusion chromatography revealed a molecular weight of 140,000. On sodium dodecyl sulfate gels, enzyme I gave one band with a molecular weight of 70,000, indicating that enzyme I consists of two identical subunits. The first 59 amino acids of the amino-terminal part of the protein have been sequenced. It showed some similarities with enzyme I of Salmonella typhimurium. The active center of enzyme I has also been determined. After phosphorylation with [32P]PEP, the enzyme was cleaved by using different proteases. Labeled peptides were isolated by high-performance liquid chromatography on a reversed-phase column. The amino acid composition or amino acid sequence of the peptides has been determined. The largest labeled peptide was obtained with Lys-C protease and had the following sequence: -Ala-Phe-Val-Thr-Asp-Ile-Gly- Gly-Arg-Thr-Ser-His*-Ser-Ala-Ile-Met-Ala-Arg-Ser-Leu-Glu-Ile-Pro-Ala- Ile-Val-Gly-Thr-Lys-. It has previously been shown that the phosphoryl group is bound to the N-3 position of a histidyl residue in phosphorylated enzyme I. The single His in position 12 of the above peptide must therefore carry the phosphoryl group

  20. Exploring clouds, weather, climate, and modeling using bilingual content and activities from the Windows to the Universe program and the Center for Multiscale Modeling of Atmospheric Processes

    Science.gov (United States)

    Foster, S. Q.; Johnson, R. M.; Randall, D.; Denning, S.; Russell, R.; Gardiner, L.; Hatheway, B.; Genyuk, J.; Bergman, J.

    2008-12-01

    The need for improving the representation of cloud processes in climate models has been one of the most important limitations of the reliability of climate-change simulations. Now in its third year, the National Science Foundation-funded Center for Multi-scale Modeling of Atmospheric Processes (CMMAP) at Colorado State University is addressing this problem through a revolutionary new approach to representing cloud processes on their native scales, including the cloud-scale interaction processes that are active in cloud systems. CMMAP has set ambitious education and human-resource goals to share basic information about the atmosphere, clouds, weather, climate, and modeling with diverse K-12 and public audiences through its affiliation with the Windows to the Universe (W2U) program at University Corporation for Atmospheric Research (UCAR). W2U web pages are written at three levels in English and Spanish. This information targets learners at all levels, educators, and families who seek to understand and share resources and information about the nature of weather and the climate system, and career role models from related research fields. This resource can also be helpful to educators who are building bridges in the classroom between the sciences, the arts, and literacy. Visitors to the W2U's CMMAP web portal can access a beautiful new clouds image gallery; information about each cloud type and the atmospheric processes that produce them; a Clouds in Art interactive; collections of weather-themed poetry, art, and myths; links to games and puzzles for children; and extensive classroom- ready resources and activities for K-12 teachers. Biographies of CMMAP scientists and graduate students are featured. Basic science concepts important to understanding the atmosphere, such as condensation, atmosphere pressure, lapse rate, and more have been developed, as well as 'microworlds' that enable students to interact with experimental tools while building fundamental knowledge

  1. Assessment of nutritional activities under integrated child development services at anganwadi centers of different districts of Gujarat from April 2012 to March 2015

    Directory of Open Access Journals (Sweden)

    Rajesh K Chudasama

    2016-01-01

    Full Text Available Background: The Integrated Child Development Service (ICDS program aims at enhancing survival and development of children from the vulnerable sections of the society. Aim: The present study was conducted to assess various nutritional activities at anganwadi centers (AWCs in different districts of Gujarat state. Settings and Design: AWCs, cross-sectional study. Materials and Methods: A total of 130 AWCs were selected including 95 from rural and 35 from urban area from April 2012 to March 2015 including 12 districts of Gujarat and union territory, Diu. Five AWCs were selected from one district randomly. Detailed information about various nutritional activities including growth monitoring, preschool education (PSE and nutrition and health education (NHED, coverage for supplementary nutrition (SN, type of food provided under SN, and its issues at AWCs was collected. Statistical Analysis: Percentages, proportions, Chi-square/Fischer's exact test. Results: Growth chart was available in 96.9% AWCs. The malnutrition was reported among 14.9% children. PSE received by all children was only in 14.6% AWCs. NHED meeting was conducted in 73.8% AWCs. High coverage of receiving SN among enrolled was reported in pregnant and lactating mothers (84.6% and adolescents (79.2%. SN was fully acceptable in 91.5% AWCs. Interruption in SN supply during last 6 months was reported in 55.4% AWCs. Conclusion: Regular workshops should be conducted for ICDS staff to sensitize them about the importance of and practices on PSE. Interruption in supply of SN should be corrected by regular and adequate provision of SN foods to the beneficiaries.

  2. Laboratory-confirmed HIV and sexually transmitted infection seropositivity and risk behavior among sexually active transgender patients at an adolescent and young adult urban community health center.

    Science.gov (United States)

    Reisner, Sari L; Vetters, Ralph; White, Jaclyn M; Cohen, Elijah L; LeClerc, M; Zaslow, Shayne; Wolfrum, Sarah; Mimiaga, Matthew J

    2015-01-01

    The sexual health of transgender adolescents and young adults who present for health care in urban community health centers is understudied. A retrospective review of electronic health record (EHR) data was conducted from 180 transgender patients aged 12-29 years seen for one or more health-care visits between 2001 and 2010 at an urban community health center serving youth in Boston, MA. Analyses were restricted to 145 sexually active transgender youth (87.3% of the sample). Laboratory-confirmed HIV and sexually transmitted infections (STIs) seroprevalence, demographics, sexual risk behavior, and structural and psychosocial risk indicators were extracted from the EHR. Analyses were descriptively focused for HIV and STIs. Stratified multivariable logistic regression models were fit for male-to-female (MTF) and female-to-male (FTM) patients separately to examine factors associated with any unprotected anal and/or vaginal sex (UAVS). The mean age was 20.0 (SD=2.9); 21.7% people of color, 46.9% white (non-Hispanic), 21.4% race/ethnicity unknown; 43.4% MTF, and 56.6% FTM; and 68.3% were on cross-sex hormones. Prevalence of STIs: 4.8% HIV, 2.8% herpes simplex virus, 2.8% syphilis, 2.1% chlamydia, 2.1% gonorrhea, 2.8% hepatitis C, 1.4% human papilloma virus. Only gonorrhea prevalence significantly differed by gender identity (MTF 2.1% vs. 0.0% FTM; p=0.046). Nearly half (47.6%) of the sample engaged in UAVS (52.4% MTF, 43.9% FTM, p=0.311). FTM more frequently had a primary sex partner compared to MTF (48.8% vs. 25.4%; p=0.004); MTF more frequently had a casual sex partner than FTM (69.8% vs. 42.7% p=0.001). In multivariable models, MTF youth who were younger in age, white non-Hispanic, and reported a primary sex partner had increased odds of UAVS; whereas, FTM youth reporting a casual sex partner and current alcohol use had increased odds of UAVS (all psexual risk differ for MTF and FTM youth. Partner type appears pivotal to understanding sexual risk in transgender

  3. Laboratory-confirmed HIV and sexually transmitted infection seropositivity and risk behavior among sexually active transgender patients at an adolescent and young adult urban community health center.

    Science.gov (United States)

    Reisner, Sari L; Vetters, Ralph; White, Jaclyn M; Cohen, Elijah L; LeClerc, M; Zaslow, Shayne; Wolfrum, Sarah; Mimiaga, Matthew J

    2015-01-01

    The sexual health of transgender adolescents and young adults who present for health care in urban community health centers is understudied. A retrospective review of electronic health record (EHR) data was conducted from 180 transgender patients aged 12-29 years seen for one or more health-care visits between 2001 and 2010 at an urban community health center serving youth in Boston, MA. Analyses were restricted to 145 sexually active transgender youth (87.3% of the sample). Laboratory-confirmed HIV and sexually transmitted infections (STIs) seroprevalence, demographics, sexual risk behavior, and structural and psychosocial risk indicators were extracted from the EHR. Analyses were descriptively focused for HIV and STIs. Stratified multivariable logistic regression models were fit for male-to-female (MTF) and female-to-male (FTM) patients separately to examine factors associated with any unprotected anal and/or vaginal sex (UAVS). The mean age was 20.0 (SD=2.9); 21.7% people of color, 46.9% white (non-Hispanic), 21.4% race/ethnicity unknown; 43.4% MTF, and 56.6% FTM; and 68.3% were on cross-sex hormones. Prevalence of STIs: 4.8% HIV, 2.8% herpes simplex virus, 2.8% syphilis, 2.1% chlamydia, 2.1% gonorrhea, 2.8% hepatitis C, 1.4% human papilloma virus. Only gonorrhea prevalence significantly differed by gender identity (MTF 2.1% vs. 0.0% FTM; p=0.046). Nearly half (47.6%) of the sample engaged in UAVS (52.4% MTF, 43.9% FTM, p=0.311). FTM more frequently had a primary sex partner compared to MTF (48.8% vs. 25.4%; p=0.004); MTF more frequently had a casual sex partner than FTM (69.8% vs. 42.7% p=0.001). In multivariable models, MTF youth who were younger in age, white non-Hispanic, and reported a primary sex partner had increased odds of UAVS; whereas, FTM youth reporting a casual sex partner and current alcohol use had increased odds of UAVS (all prisk differ for MTF and FTM youth. Partner type appears pivotal to understanding sexual risk in transgender adolescents

  4. CDBG Public Improvements Activity

    Data.gov (United States)

    Department of Housing and Urban Development — CDBG activity related to public improvements, including senior centers, youth centers, parks, street improvements, water/sewer improvements, child care centers,...

  5. ENVIRONMENTAL BIOINFORMATICS AND COMPUTATIONAL TOXICOLOGY CENTER

    Science.gov (United States)

    The Center activities focused on integrating developmental efforts from the various research projects of the Center, and collaborative applications involving scientists from other institutions and EPA, to enhance research in critical areas. A representative sample of specif...

  6. Italy INAF Analysis Center Report

    Science.gov (United States)

    Negusini, M.; Sarti, P.

    2013-01-01

    This report summarizes the activity of the Italian INAF VLBI Analysis Center. Our Analysis Center is located in Bologna, Italy and belongs to the Institute of Radioastronomy, which is part of the National Institute of Astrophysics. IRA runs the observatories of Medicina and Noto, where two 32-m VLBI AZ-EL telescopes are situated. This report contains the AC's VLBI data analysis activities and shortly outlines the investigations into the co-locations of space geodetic instruments.

  7. Senior Centers

    Medline Plus

    Full Text Available ... to new activities and expand a person’s social contacts. [Karen Albers] Participants’ needs are fulfilled by receiving ... long-term care services available in your community, contact the Eldercare Locator at 1-800-677-1116. ...

  8. Patient-centered Care.

    Science.gov (United States)

    Reynolds, April

    2009-01-01

    Patient-centered care focuses on the patient and the individual's particular health care needs. The goal of patient-centered health care is to empower patients to become active participants in their care. This requires that physicians, radiologic technologists and other health care providers develop good communication skills and address patient needs effectively. Patient-centered care also requires that the health care provider become a patient advocate and strive to provide care that not only is effective but also safe. For radiologic technologists, patient-centered care encompasses principles such as the as low as reasonably achievable (ALARA) concept and contrast media safety. Patient-centered care is associated with a higher rate of patient satisfaction, adherence to suggested lifestyle changes and prescribed treatment, better outcomes and more cost-effective care. This article is a Directed Reading. Your access to Directed Reading quizzes for continuing education credit is determined by your area of interest. For access to other quizzes, go to www.asrt.org/store. According to one theory, most patients judge the quality of their healthcare much like they rate an airplane flight. They assume that the airplane is technically viable and is being piloted by competent people. Criteria for judging a particular airline are personal and include aspects like comfort, friendly service and on-time schedules. Similarly, patients judge the standard of their healthcare on nontechnical aspects, such as a healthcare practitioner's communication and "soft skills." Most are unable to evaluate a practitioner's level of technical skill or training, so the qualities they can assess become of the utmost importance in satisfying patients and providing patient-centered care.(1). PMID:19901351

  9. The vascular disrupting agent STA-9584 exhibits potent antitumor activity by selectively targeting microvasculature at both the center and periphery of tumors.

    Science.gov (United States)

    Foley, Kevin P; Zhou, Dan; Borella, Chris; Wu, Yaming; Zhang, Mei; Jiang, Jun; Li, Hao; Sang, Jim; Korbut, Tim; Ye, Josephine; Zhang, Xuemei; Barsoum, James; Sonderfan, Andrew J

    2012-11-01

    Vascular disrupting agents (VDAs) are an emerging class of therapeutics targeting the existing vascular network of solid tumors. However, their clinical progression has been hampered because of limited single-agent efficacy, primarily caused by the persistence of surviving cells at the well perfused "viable rim" of tumors, which allows rapid tumor regrowth to occur. In addition, off-target adverse events, including cardiovascular toxicities, underscore a need for compounds with improved safety profiles. Here, we characterize the mechanism of action, antitumor efficacy, and cardiovascular safety profile of (S)-2-amino-N-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)isoxazol-4-yl)phenyl)-3-phenylpropanamide hydrochloride (STA-9584), a novel tubulin-binding VDA. In vitro, 2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)isoxazol-4-yl)aniline (STA-9122) (active metabolite of STA-9584) displayed increased potency relative to other tubulin-binding agents and was highly cytotoxic to tumor cells. STA-9584 induced significant tumor regressions in prostate and breast xenograft models in vivo and, in an aggressive syngeneic model, demonstrated superior tumor growth inhibition and a positive therapeutic index relative to combretastatin A-4 phosphate (CA4P). It is noteworthy that histological analysis revealed that STA-9584 disrupted microvasculature at both the center and periphery of tumors. Compared with CA4P, STA-9584 induced a 73% increase in central necrotic area, 77% decrease in microvasculature, and 7-fold increase in tumor cell apoptosis in the remaining viable rim 24 h post-treatment. Ultrasound imaging confirmed that STA-9584 rapidly and efficiently blocked blood flow in highly perfused tumor regions. Moreover, cardiovascular effects were evaluated in the Langendorff assay and telemetered dogs, and cardiovascular toxicity was not predicted to be dose-limiting. This bioactivity profile distinguishes STA-9584 from the combretastatin class and identifies the compound as a promising new

  10. Cytokine-Independent Detection of Antigen-Specific Germinal Center T Follicular Helper Cells in Immunized Nonhuman Primates Using a Live Cell Activation-Induced Marker Technique.

    Science.gov (United States)

    Havenar-Daughton, Colin; Reiss, Samantha M; Carnathan, Diane G; Wu, Jennifer E; Kendric, Kayla; Torrents de la Peña, Alba; Kasturi, Sudhir Pai; Dan, Jennifer M; Bothwell, Marcella; Sanders, Rogier W; Pulendran, Bali; Silvestri, Guido; Crotty, Shane

    2016-08-01

    A range of current candidate AIDS vaccine regimens are focused on generating protective HIV-neutralizing Ab responses. Many of these efforts rely on the rhesus macaque animal model. Understanding how protective Ab responses develop and how to increase their efficacy are both major knowledge gaps. Germinal centers (GCs) are the engines of Ab affinity maturation. GC T follicular helper (Tfh) CD4 T cells are required for GCs. Studying vaccine-specific GC Tfh cells after protein immunizations has been challenging, as Ag-specific GC Tfh cells are difficult to identify by conventional intracellular cytokine staining. Cytokine production by GC Tfh cells may be intrinsically limited in comparison with other Th effector cells, as the biological role of a GC Tfh cell is to provide help to individual B cells within the GC, rather than secreting large amounts of cytokines bathing a tissue. To test this idea, we developed a cytokine-independent method to identify Ag-specific GC Tfh cells. RNA sequencing was performed using TCR-stimulated GC Tfh cells to identify candidate markers. Validation experiments determined CD25 (IL-2Rα) and OX40 to be highly upregulated activation-induced markers (AIM) on the surface of GC Tfh cells after stimulation. In comparison with intracellular cytokine staining, the AIM assay identified >10-fold more Ag-specific GC Tfh cells in HIV Env protein-immunized macaques (BG505 SOSIP). CD4 T cells in blood were also studied. In summary, AIM demonstrates that Ag-specific GC Tfh cells are intrinsically stingy producers of cytokines, which is likely an essential part of their biological function. PMID:27335502

  11. State Institution "National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine" - research activities and scientific advance in 2013.

    Science.gov (United States)

    Bazyka, D; Sushko, V; Chumak, A; Buzunov, V; Talko, V; Yanovych, L

    2014-09-01

    Research activities and scientific advance achieved in 2013 at the State Institution "National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine" (NRCRM) concerning medical problems of the Chornobyl disaster, radiation medicine, radiobiology, radiation hygiene and epidemiology in collaboration with the WHO network of medical preparedness and assistance in radiation accidents are outlined in the annual report. Key points include the research results of XRCC1 and XPD gene polymorphism in thyroid cancer patients, CD38 gene GG genotype as a risk factor for chronic lymphocytic leukemia, frequency of 185delAG and 5382insC mutations in BRCA1 gene in women with breast cancer, cognitive function and TERF1, TERF2, TERT gene expression both with telomere length in human under the low dose radiation exposure. The "source-scattering/shielding structures- man" models for calculation of partial dose values to the eye lens and new methods for radiation risk assessment were developed and adapted. Radiation risks of leukemia including chronic lymphocytic leukemia in the cohort of liquidators were published according to the "case-control" study results after 20 years of survey. Increase of non-tumor morbidity in liquidators during the 1988-2011 with the maximum level 12-21 years upon irradiation was found. Incidence in evacuees appeared being of two-peak pattern i.e. in the first years after the accident and 12 years later. Experimental studies have concerned the impact of radio-modifiers on cellular systems, reproductive function in the population, features of the child nutrition in radiation contamination area were studied. Report also shows the results of scientific and organizational, medical and preventive work, staff training, and implementation of innovations. The NRCRM Annual Report was approved at the Scientific Council meeting of NAMS on March 3, 2014.

  12. Quality Assurance Plan for Field Activities at the Natural and Accelerated Bioremediation Research (NABIR) Field Research Center (FRC), Oak Ridge, Tennessee

    Energy Technology Data Exchange (ETDEWEB)

    Brandt, C.C.

    2002-02-28

    The Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) has established a Natural and Accelerated Bioremediation Research (NABIR) program Field Research Center (FRC) for the U.S. Department of Energy (DOE) Office of Biological and Environmental Research. The FRC is located in Bear Creek Valley within the Y-12 Plant area of responsibility on DOE's Oak Ridge Reservation in Tennessee. The NABIR program is a long-term effort designed to increase the understanding of fundamental biogeochemical processes that would allow the use of bioremediation approaches for cleaning up DOE's contaminated legacy waste sites. The FRC provides a site for investigators in the NABIR program to conduct research and obtain samples related to in situ bioremediation. The FRC is integrated with existing and future laboratory and field research and provides a means of examining the biogeochemical processes that influence bioremediation under controlled small-scale field conditions. This Quality Assurance Plan (QAP) documents the quality assurance protocols for field and laboratory activities performed by the FRC staff. It supplements the requirements in the ORNL Nuclear Quality Assurance Program and the ESD Quality Assurance Program. The QAP addresses the requirements in Title 10 CFR, Part 830 Subpart A, ''Quality Assurance Requirements'', using a graded approach appropriate for Research and Development projects based on guidance from ''Implementation Guide for Quality Assurance Programs for Basic and Applied Research'' (DOE-ER-STD-6001-92). It also supports the NABIR FRC Management Plan (Watson and Quarles 2000a) which outlines the overall procedures, roles and responsibilities for conducting research at the FRC. The QAP summarizes the organization, work activities, and qualify assurance and quality control protocols that will be used to generate scientifically defensible data at the FRC. The QAP pertains to field

  13. CENTER AS A TOOL FOR LOGISTICS ACTIVITIES IN SUPPORT OF THE COMPANY ON THE EXAMPLE OF SME’s ENTERPRISE X

    OpenAIRE

    Janusz Grabara; Paula Bajdor; Bartlomiej Okwiet

    2010-01-01

    Costs are in all aspects of each company. Some of the most noticeable costs of business are the costs associated with storage, transportation and distribution the products of the company. In this case a significant impact on reducing these costs is to use the services of logistics centers, specializing in trading all kinds of goods. The purpose of this article is to show how the transfer of logistical supplies from the distribution center logistics contributes to a significant reduction in co...

  14. Non-tuberculous mycobacteria I: one year clinical isolates identification in Tertiary Hospital Aids Reference Center, Rio de Janeiro, Brazil, in pre highly active antiretroviral therapy era

    Directory of Open Access Journals (Sweden)

    Ferreira Rosa Maria Carvalho

    2002-01-01

    Full Text Available The aim of this study was to determine the prevalence of non-tuberculous mycobacteria (NTM isolates at University Hospital, Reference Center for Aids in Rio de Janeiro, Brazil, during one year. We used standard biochemical tests for species identification and IS1245 PCR amplification was applied as a Mycobacterium avium specific identification marker. Four hundred and four specimens from 233 patients yielded acid-fast bacilli growth. M. tuberculosis was identified in 85% of the patients and NTM in 15%. NTM disseminated infection was a common event correlated with human immunodeficiency virus (HIV infected patients and only in HIV negative patients the source of NTM was non sterile site. M. avium complex (MAC was biochemically identified in 57.8% (49/83 of NTM isolates, most of them from sterile sites (75.5%, and in 94% (46/49 the IS 1245 marker specific for M. avium was present. Twenty NTM strains showed a MAC biochemical pattern with the exception of a urease-positive (99% of MAC are urease-negative, however IS1245 was detected in 96% of the strains leading to their identification as M. avium. In this group differences in NTM source was not significant. The second most frequently isolated NTM was identified as M. scrofulaceum (7.2%, followed by M. terrae (3.6%, M. gordonae (2.4%, M. chelonae (1.2%, M. fortuitum (1.2% and one strain which could not be identified. All were IS1245 negative except for one strain identified as M. scrofulaceum. It is interesting to note that non-sterile sites were the major source of these isolates (92.8%. Our finding indicated that M. avium is still the major atypical species among in the MAC isolates recovered from Brazilian Aids patients without highty active antiretroviral therapy schema. Some discrepancies were seen between the identification methods and further investigations must be done to better characterize NTM isolates using other phenotypic and genotypic methods.

  15. Une maison de culture (A Culture Center).

    Science.gov (United States)

    Mourlevat, Alain

    1980-01-01

    Describes the "Culture Center" designed by Le Corbusier and located in Firminy, France. The role of the center in arousing intellectual curiosity in people living in a technological age is discussed. The audience of this culture center, young people, and the types of activities directed toward them are described. (AMH)

  16. Report on the Center for Spatial Studies

    OpenAIRE

    Hegarty, Mary; GOODCHILD Michael; Janelle, Donald; Doehner, Karen

    2013-01-01

    This report documents the education, research, and outreach activities of the Center for the period beginning in July 2010. In addition, it presents a vision for the center based on plans set forth by the incoming (Dec. 2013) Director of the Center, Dr. Werner Kuhn.

  17. Information on the Karlsruhe Nuclear Research Center

    International Nuclear Information System (INIS)

    A short overview is given about the origins of Karlsruhe Nuclear Research Center. The historical development of the different companies operating the Center is shown. Because the original task assigned to the Center was the construction and testing of the first German reactor exclusively built by German companies, a detailed description of this reactor and the changes made afterwards is presented. Next, today's organizational structure of the Center is outlined and the development of the Center's financing since its foundation is shown. A short overview about the structure of employees from the Center's beginning up to now is also included as well as a short description of today's main activities. (orig.)

  18. Call Center ist nicht gleich Call Center

    OpenAIRE

    Baumgartner, Marc; Udris, Ivars

    2005-01-01

    Untersuchungen in 14 Schweizer Call Centers erbrachten vier Call Center-Typen, die sich hinsichtlich Arbeitstätigkeiten und Kommunikationsrichtung voneinander unterscheiden: (a) Beratungs- und Beschwerdemanagement, (b) Informationsmanagement, (c) Auftragsmanagement und (d) Kunden- und Kampagnenmanagement. Dies hat auch Auswirkungen auf die Personalstruktur, -selektion und -entwicklung der Call Center. Es wird der Frage nachgegangen, welche Kompetenzanforderungen in den unterschiedlichen Call ...

  19. Sustainable Biofuels Development Center

    Energy Technology Data Exchange (ETDEWEB)

    Reardon, Kenneth F. [Colorado State Univ., Fort Collins, CO (United States)

    2015-03-01

    The mission of the Sustainable Bioenergy Development Center (SBDC) is to enhance the capability of America’s bioenergy industry to produce transportation fuels and chemical feedstocks on a large scale, with significant energy yields, at competitive cost, through sustainable production techniques. Research within the SBDC is organized in five areas: (1) Development of Sustainable Crops and Agricultural Strategies, (2) Improvement of Biomass Processing Technologies, (3) Biofuel Characterization and Engine Adaptation, (4) Production of Byproducts for Sustainable Biorefining, and (5) Sustainability Assessment, including evaluation of the ecosystem/climate change implication of center research and evaluation of the policy implications of widespread production and utilization of bioenergy. The overall goal of this project is to develop new sustainable bioenergy-related technologies. To achieve that goal, three specific activities were supported with DOE funds: bioenergy-related research initiation projects, bioenergy research and education via support of undergraduate and graduate students, and Research Support Activities (equipment purchases, travel to attend bioenergy conferences, and seminars). Numerous research findings in diverse fields related to bioenergy were produced from these activities and are summarized in this report.

  20. Sustainable Biofuels Development Center

    Energy Technology Data Exchange (ETDEWEB)

    SRIVASTAVA, PREM

    2015-03-02

    The mission of the Sustainable Bioenergy Development Center (SBDC) is to enhance the capability of America’s bioenergy industry to produce transportation fuels and chemical feedstocks on a large scale, with significant energy yields, at competitive cost, through sustainable production techniques. Research within the SBDC is organized in five areas: (1) Development of Sustainable Crops and Agricultural Strategies, (2) Improvement of Biomass Processing Technologies, (3) Biofuel Characterization and Engine Adaptation, (4) Production of Byproducts for Sustainable Biorefining, and (5) Sustainability Assessment, including evaluation of the ecosystem/climate change implication of center research and evaluation of the policy implications of widespread production and utilization of bioenergy. The overall goal of this project is to develop new sustainable bioenergy-related technologies. To achieve that goal, three specific activities were supported with DOE funds: bioenergy-related research initiation projects, bioenergy research and education via support of undergraduate and graduate students, and Research Support Activities (equipment purchases, travel to attend bioenergy conferences, and seminars). Numerous research findings in diverse fields related to bioenergy were produced from these activities and are summarized in this report.

  1. The Expositional Activity of the Public State Institution of the Volgograd Region “Documentation Center of the Modern History of the Volgograd Region” Devoted to the 70th Anniversary of the Great Victory

    Directory of Open Access Journals (Sweden)

    Natalya A. Nasonova

    2015-09-01

    Full Text Available The article considers the exhibition activity of the Public State Institution of the Volgograd Region “Documentation Center of the Modern History of the Volgograd Region” in 2014–2015 devoted to the Great Patriotic War. The article describes the composition and content of archival funds of this institution, where the documents concerning different aspects of the Stalingrad Region life during the Great Patriotic War and the Stalingrad battle are held.

  2. Sexually Active Teenagers Are More Likely To Be Depressed and To Attempt Suicide. A Report of the Heritage Center for Data Analysis.

    Science.gov (United States)

    Rector, Robert E.; Johnson, Kirk A.; Noyes, Lauren R.

    Although teen sexual activity has declined in recent years, the overall rate is still high. The problems associated with teen sexual activity are well known. Less widely known are the psychological and emotional problems associated with this activity. The present study examines the linkage between teenage sexual activity and emotional health. The…

  3. Children's cancer centers

    Science.gov (United States)

    Pediatric cancer center; Pediatric oncology center; Comprehensive cancer center ... Treating childhood cancer is not the same as treating adult cancer. The cancers are different. So are the treatments and the ...

  4. Communication between Thiamin Cofactors in the Escherichia coli Pyruvate Dehydrogenase Complex E1 Component Active Centers EVIDENCE FOR A DIRECT PATHWAY BETWEEN THE 4′-AMINOPYRIMIDINE N1′ ATOMS

    Energy Technology Data Exchange (ETDEWEB)

    Nemeria, Natalia S; Arjunan, Palaniappa; Chandrasekhar, Krishnamoorthy; Mossad, Madouna; Tittmann, Kai; Furey, William; Jordan, Frank [Pitt; (Goettingen); (VA); (Rutgers)

    2010-11-03

    Kinetic, spectroscopic, and structural analysis tested the hypothesis that a chain of residues connecting the 4{prime}-aminopyrimidine N1{prime} atoms of thiamin diphosphates (ThDPs) in the two active centers of the Escherichia coli pyruvate dehydrogenase complex E1 component provides a signal transduction pathway. Substitution of the three acidic residues (Glu{sup 571}, Glu{sup 235}, and Glu{sup 237}) and Arg{sup 606} resulted in impaired binding of the second ThDP, once the first active center was filled, suggesting a pathway for communication between the two ThDPs. (1) Steady-state kinetic and fluorescence quenching studies revealed that upon E571A, E235A, E237A, and R606A substitutions, ThDP binding in the second active center was affected. (2) Analysis of the kinetics of thiazolium C2 hydrogen/deuterium exchange of enzyme-bound ThDP suggests half-of-the-sites reactivity for the E1 component, with fast (activated site) and slow exchanging sites (dormant site). The E235A and E571A variants gave no evidence for the slow exchanging site, indicating that only one of two active sites is filled with ThDP. (3) Titration of the E235A and E237A variants with methyl acetylphosphonate monitored by circular dichroism suggested that only half of the active sites were filled with a covalent predecarboxylation intermediate analog. (4) Crystal structures of E235A and E571A in complex with ThDP revealed the structural basis for the spectroscopic and kinetic observations and showed that either substitution affects cofactor binding, despite the fact that Glu{sup 235} makes no direct contact with the cofactor. The role of the conserved Glu{sup 571} residue in both catalysis and cofactor orientation is revealed by the combined results for the first time.

  5. OPPORTUNITIES OF EXERCISING THE ROLE OF AN ACTIVE STUDENT AS A PREMISE OF STUDENT-CENTERED EDUCATION IN THE ECONOMIC SCIENCES FACULTY OF THE UNIVERSITY OF ORADEA

    Directory of Open Access Journals (Sweden)

    Rosca Remus Dorel

    2014-07-01

    The ideas presented in this paper are to represent a part of a good practice guide on implementing student-centered education within a high educational institution. The concern for this concept is determined by the current context of the high educational system in Romania characterized by: the intensification of the competitive environment; increasing employers’ demands; increasing high school graduates and students’ demands towards the quality offered by a high educational institution; the performance indicators used by ARACIS in the evaluation of the universities, a very relevant example being the graduates’ professional route in the labour field. We are convinced that the ideas presented in this paper are important to the decision factors from the academic environment, factors that should initiate and facilitate the implementation of the student- centered education concept.

  6. Caring for people with dementia in residential aged care: successes with a composite person-centered care model featuring Montessori-based activities.

    Science.gov (United States)

    Roberts, Gail; Morley, Catherine; Walters, Wendy; Malta, Sue; Doyle, Colleen

    2015-01-01

    Person-centered models of dementia care commonly merge aspects of existing models with additional influences from published and unpublished evidence and existing government policy. This study reports on the development and evaluation of one such composite model of person-centered dementia care, the ABLE model. The model was based on building the capacity and ability of residents living with dementia, using environmental changes, staff education and organizational and community engagement. Montessori principles were also used. The evaluation of the model employed mixed methods. Significant behavior changes were evident among residents of the dementia care Unit after the model was introduced, as were reductions in anti-psychotic and sedative medication. Staff reported increased knowledge about meeting the needs of people with dementia, and experienced organizational culture change that supported the ABLE model of care. Families were very satisfied with the changes. PMID:25499658

  7. Enhancement of laccase activity through the construction and breakdown of a hydrogen bond at the type I copper center in Escherichia coli CueO and the deletion mutant Δα5-7 CueO.

    Science.gov (United States)

    Kataoka, Kunishige; Hirota, Shun; Maeda, Yasuo; Kogi, Hiroki; Shinohara, Naoya; Sekimoto, Madoka; Sakurai, Takeshi

    2011-02-01

    CueO is a multicopper oxidase involved in a copper efflux system of Escherichia coli and has high cuprous oxidase activity but little or no oxidizing activity toward various organic substances. However, its activity toward oxidization of organic substrates was found to be considerably increased by the removal of the methionine-rich helical segment that covers the substrate-binding site (Δα5-7 CueO) [Kataoka, K., et al. (2007) J. Mol. Biol. 373, 141]. In the study presented here, mutations at Pro444 to construct a second NH-S hydrogen bond between the backbone amide and coordinating Cys500 thiolate of the type I copper are shown to result in positive shifts in the redox potential of this copper center and enhanced oxidase activity in CueO. Analogous enhancement of the activity of Δα5-7 CueO has been identified only in the Pro444Gly mutant because Pro444 mutants limit the incorporation of copper ions into the trinuclear copper center. The activities of both CueO and Δα5-7 CueO were also enhanced by mutations to break down the hydrogen bond between the imidazole group of His443 that is coordinated to the type I copper and the β-carboxy group of Asp439 that is located in the outer sphere of the type I copper center. A synergetic effect of the positive shift in the redox potential of the type I copper center and the increase in enzyme activity has been achieved by the double mutation of Pro444 and Asp439 of CueO. Absorption, circular dichroism, and resonance Raman spectra indicate that the characteristics of the Cu(II)-S(Cys) bond were only minimally perturbed by mutations involving formation or disruption of a hydrogen bond from the coordinating groups to the type I copper. This study provides widely applicable strategies for tuning the activities of multicopper oxidases.

  8. Synthesis of the First Example of the 12-Vertex-closo/12-Vertex-nido Biscarborane Cluster by a Metal-Free B-H Activation at a Phosphorus(III) Center.

    Science.gov (United States)

    Wong, Yuen Onn; Smith, Mark D; Peryshkov, Dmitry V

    2016-05-10

    An unusual 12-vertex-closo-C2 B10 /12-vertex-nido-C2 B10 biscarborane cluster was synthesized through an unprecedented regioselective metal-free B-H activation by a sterically hindered P(III) center under mild conditions accompanied by cage-opening rearrangement. A combination of the electron-accepting properties of a carborane cage and steric enforcement of close interatomic contacts represent a new synthetic strategy for the activation of strong B-H bonds in carboranes. PMID:26990216

  9. Enhancement of laccase activity through the construction and breakdown of a hydrogen bond at the type I copper center in Escherichia coli CueO and the deletion mutant Δα5-7 CueO.

    Science.gov (United States)

    Kataoka, Kunishige; Hirota, Shun; Maeda, Yasuo; Kogi, Hiroki; Shinohara, Naoya; Sekimoto, Madoka; Sakurai, Takeshi

    2011-02-01

    CueO is a multicopper oxidase involved in a copper efflux system of Escherichia coli and has high cuprous oxidase activity but little or no oxidizing activity toward various organic substances. However, its activity toward oxidization of organic substrates was found to be considerably increased by the removal of the methionine-rich helical segment that covers the substrate-binding site (Δα5-7 CueO) [Kataoka, K., et al. (2007) J. Mol. Biol. 373, 141]. In the study presented here, mutations at Pro444 to construct a second NH-S hydrogen bond between the backbone amide and coordinating Cys500 thiolate of the type I copper are shown to result in positive shifts in the redox potential of this copper center and enhanced oxidase activity in CueO. Analogous enhancement of the activity of Δα5-7 CueO has been identified only in the Pro444Gly mutant because Pro444 mutants limit the incorporation of copper ions into the trinuclear copper center. The activities of both CueO and Δα5-7 CueO were also enhanced by mutations to break down the hydrogen bond between the imidazole group of His443 that is coordinated to the type I copper and the β-carboxy group of Asp439 that is located in the outer sphere of the type I copper center. A synergetic effect of the positive shift in the redox potential of the type I copper center and the increase in enzyme activity has been achieved by the double mutation of Pro444 and Asp439 of CueO. Absorption, circular dichroism, and resonance Raman spectra indicate that the characteristics of the Cu(II)-S(Cys) bond were only minimally perturbed by mutations involving formation or disruption of a hydrogen bond from the coordinating groups to the type I copper. This study provides widely applicable strategies for tuning the activities of multicopper oxidases. PMID:21142169

  10. Womens Business Center

    Data.gov (United States)

    Small Business Administration — Women's Business Centers (WBCs) represent a national network of nearly 100 educational centers throughout the United States and its territories, which are designed...

  11. Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas.

    Directory of Open Access Journals (Sweden)

    Sarah K Knutson

    Full Text Available Patients with non-Hodgkin lymphoma (NHL are treated today with a cocktail of drugs referred to as CHOP (Cyclophosphamide, Hydroxyldaunorubicin, Oncovin, and Prednisone. Subsets of patients with NHL of germinal center origin bear oncogenic mutations in the EZH2 histone methyltransferase. Clinical testing of the EZH2 inhibitor EPZ-6438 has recently begun in patients. We report here that combining EPZ-6438 with CHOP in preclinical cell culture and mouse models results in dramatic synergy for cell killing in EZH2 mutant germinal center NHL cells. Surprisingly, we observe that much of this synergy is due to Prednisolone - a glucocorticoid receptor agonist (GRag component of CHOP. Dramatic synergy was observed when EPZ-6438 is combined with Prednisolone alone, and a similar effect was observed with Dexamethasone, another GRag. Remarkably, the anti-proliferative effect of the EPZ-6438+GRag combination extends beyond EZH2 mutant-bearing cells to more generally impact germinal center NHL. These preclinical data reveal an unanticipated biological intersection between GR-mediated gene regulation and EZH2-mediated chromatin remodeling. The data also suggest the possibility of a significant and practical benefit of combining EZH2 inhibitors and GRag that warrants further investigation in a clinical setting.

  12. The human capacity building support activities of the Integrated Support Center for Nuclear Nonproliferation and Nuclear Security and the cooperation with the international or foreign organizations which handles human capacity building support

    International Nuclear Information System (INIS)

    The Integrated Support Center for Nuclear Nonproliferation and Nuclear Security (ISCN) of the Japan Atomic Energy Agency has started its human capacity building activities, domestically and internationally, for the government officials and employees of companies of emerging nuclear power countries mainly in Asia. In this paper, we will describe the activities of ISCN on capacity building for these countries and also I will briefly describe, focusing on nuclear security, the activities of IAEA, Sandia National Laboratory of United States, Russia and the development of human capacity building support activities of neighboring countries of China and Korea. By doing this, we will describe the relationship and cooperation of ISCN with these organizations and hope that this would help us for the future development with these organizations and ISCN. (author)

  13. Center for Beam Physics, 1993

    Energy Technology Data Exchange (ETDEWEB)

    1994-05-01

    The Center for Beam Physics is a multi-disciplinary research and development unit in the Accelerator and Fusion Research Division at Lawrence Berkeley Laboratory. At the heart of the Center`s mission is the fundamental quest for mechanisms of acceleration, radiation and focusing of energy. Dedicated to exploring the frontiers of the physics of (and with) particle and photon beams, its primary mission is to promote the science and technology of the production, manipulation, storage and control systems of charged particles and photons. The Center serves this mission via conceptual studies, theoretical and experimental research, design and development, institutional project involvement, external collaborations, association with industry and technology transfer. This roster provides a glimpse at the scientists, engineers, technical support, students, and administrative staff that make up this team and a flavor of their multifaceted activities during 1993.

  14. Student Success Center Toolkit

    Science.gov (United States)

    Jobs For the Future, 2014

    2014-01-01

    "Student Success Center Toolkit" is a compilation of materials organized to assist Student Success Center directors as they staff, launch, operate, and sustain Centers. The toolkit features materials created and used by existing Centers, such as staffing and budgeting templates, launch materials, sample meeting agendas, and fundraising…

  15. The Self-Assessment of Role-Performance and Activities of Daily Living Abilities (SARA™): Development and Clinical Utility of a Client-Centered Screening Tool and Outcome Measure.

    Science.gov (United States)

    Watkins, Sarah L; Lounsbury, Peggy A; Fleming-Castaldy, Rita P

    2016-01-01

    This article describes the development and use of the Self-Assessment of Role-performance and activities of daily living Abilities (SARA™), a standardized client-centered index of functional abilities. Developed in four phases, this article describes the initial development, pilot testing and revision, examination of psychometric properties, and finalization. Pilot studies found the SARA™ to be reliable, valid, and responsive to change. The use of the SARA™ in clinical practice and for outcome monitoring promotes client-centered goal setting and client-valued rehabilitation. It is a viable alternative to deficit-focused measures. The SARA™ is a promising new tool that warrants increased utilization and further research. PMID:26115016

  16. The 10th Anniversary Of Daejeon Environmental Technology Development Center

    International Nuclear Information System (INIS)

    This book describes the Daejeon Environment Technology Development Center with pictures for ten years. It also introduces the purpose of the foundation and background of center, structure of the center, main project and role of the center, center logo, current situation of cost of project, research business for 10 years, business supporting the environmental corporate, environment education, public relations activity and vision and prospect of the Daejeon Environmental Technology Development Center.

  17. Solar Technology Center

    Energy Technology Data Exchange (ETDEWEB)

    Boehm, Bob

    2011-04-27

    The Department of Energy, Golden Field Office, awarded a grant to the UNLV Research Foundation (UNLVRF) on August 1, 2005 to develop a solar and renewable energy information center. The Solar Technology Center (STC) is to be developed in two phases, with Phase I consisting of all activities necessary to determine feasibility of the project, including design and engineering, identification of land access issues and permitting necessary to determine project viability without permanently disturbing the project site, and completion of a National Environmental Policy Act (NEPA) Environmental Assessment. Phase II is the installation of infrastructure and related structures, which leads to commencement of operations of the STC. The STC is located in the Boulder City designated 3,000-acre Eldorado Valley Energy Zone, approximately 15 miles southwest of downtown Boulder City and fronting on Eldorado Valley Drive. The 33-acre vacant parcel has been leased to the Nevada Test Site Development Corporation (NTSDC) by Boulder City to accommodate a planned facility that will be synergistic with present and planned energy projects in the Zone. The parcel will be developed by the UNLVRF. The NTSDC is the economic development arm of the UNLVRF. UNLVRF will be the entity responsible for overseeing the lease and the development project to assure compliance with the lease stipulations established by Boulder City. The STC will be operated and maintained by University of Nevada, Las Vegas (UNLV) and its Center for Energy Research (UNLV-CER). Land parcels in the Eldorado Valley Energy Zone near the 33-acre lease are committed to the construction and operation of an electrical grid connected solar energy production facility. Other projects supporting renewable and solar technologies have been developed within the energy zone, with several more developments in the horizon.

  18. The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells.

    Science.gov (United States)

    Whisenant, Thomas C; Peralta, Eigen R; Aarreberg, Lauren D; Gao, Nina J; Head, Steven R; Ordoukhanian, Phillip; Williamson, Jamie R; Salomon, Daniel R

    2015-01-01

    Activation of CD4 T cells is a reaction to challenges such as microbial pathogens, cancer and toxins that defines adaptive immune responses. The roles of T cell receptor crosslinking, intracellular signaling, and transcription factor activation are well described, but the importance of post-transcriptional regulation by RNA-binding proteins (RBPs) has not been considered in depth. We describe a new model expanding and activating primary human CD4 T cells and applied this to characterizing activation-induced assembly of splicing factors centered on U2AF2. We immunoprecipitated U2AF2 to identify what mRNA transcripts were bound as a function of activation by TCR crosslinking and costimulation. In parallel, mass spectrometry revealed the proteins incorporated into the U2AF2-centered RNA/protein interactome. Molecules that retained interaction with the U2AF2 complex after RNAse treatment were designated as "central" interactome members (CIMs). Mass spectrometry also identified a second class of activation-induced proteins, "peripheral" interactome members (PIMs), that bound to the same transcripts but were not in physical association with U2AF2 or its partners. siRNA knockdown of two CIMs and two PIMs caused changes in activation marker expression, cytokine secretion, and gene expression that were unique to each protein and mapped to pathways associated with key aspects of T cell activation. While knocking down the PIM, SYNCRIP, impacts a limited but immunologically important set of U2AF2-bound transcripts, knockdown of U2AF1 significantly impairs assembly of the majority of protein and mRNA components in the activation-induced interactome. These results demonstrated that CIMs and PIMs, either directly or indirectly through RNA, assembled into activation-induced U2AF2 complexes and play roles in post-transcriptional regulation of genes related to cytokine secretion. These data suggest an additional layer of regulation mediated by the activation-induced assembly of RNA

  19. The Life Cycles of Stars: An Information & Activity Booklet Grades K-8, 1997-1998. Star-Child--A Learning Center for Young Astronomers.

    Science.gov (United States)

    Truelove, Elizabeth; Dejoie, Joyce

    This booklet contains information and activities on the life cycle of stars. Materials can be adapted for kindergarten through grade 8 classrooms. Background information on massive stars and medium stars and activities with subjects such as star life, constellation shapes, nebula terminology, astronomical distances, and pulsars is included. The 12…

  20. Starting Right: Using "Biophilia," Organism Cards, & Key Themes in Biology to Introduce Student-Centered Active-Learning Strategies at the Beginning of a Course

    Science.gov (United States)

    Metzger, Kelsey

    2013-01-01

    To create rich learning experiences, it is important to engage students from the very beginning of a course and lay the foundation for constructing a community of active learners. The activities described here using "organism cards" connect students' previous knowledge to course goals and address key themes in biology while initiating…

  1. Starchild Presents...StarChild: A Learning Center for Young Astronomers. Black Holes. An Information and Activity Booklet. Grades K-8, 1998-1999.

    Science.gov (United States)

    Truelove, Elizabeth; Dejoie, Joyce

    The information provided in this booklet is meant to give the necessary background information so that the science of black holes can be taught confidently to elementary students. The featured activities can be used to engage and excite students about the topic of black holes in different disciplines and in a number of ways. Activities include:…

  2. Coal Ash Behavior in Reducing Environments (CABRE) III Year 6 - Activity 1.10 - Development of a National Center for Hydrogen

    Energy Technology Data Exchange (ETDEWEB)

    Stanislowski, Joshua; Azenkeng, Alexander; McCollor, Donald; Galbreath, Kevin; Jensen, Robert; Lahr, Brent

    2012-03-31

    The Energy & Environmental Research Center (EERC) has been conducting research on gasification for six decades. One of the objectives of this gasification research has been to maximize carbon conversion and the water–gas shift process for optimal hydrogen production and syngas quality. This research focus and experience were a perfect fit for the National Center for Hydrogen Technology ® (NCHT®) Program at the EERC for improving all aspects of coal gasification, which ultimately aids in the production and purification of hydrogen. A consortia project was developed under the NCHT Program to develop an improved predictive model for ash formation and deposition under the project entitled “Coal Ash Behavior in Reducing Environments (CABRE) III: Development of the CABRE III Model.” The computer-based program is now applicable to the modeling of coal and ash behavior in both entrained-flow and fluidized-bed gasification systems to aid in overall gasification efficiency. This model represents a significant improvement over the CABRE II model and runs on a Microsoft Windows PC platform. The major achievements of the CABRE III model are partitioning of inorganic transformations between various phases for specific gas cleanup equipment; slag property predictions, including standard temperature–viscosity curves and slag flow and thickness; deposition rates in gasification cleanup equipment; provision for composition analysis for all input and output streams across all process equipment, including major elements and trace elements of interest; composition analysis of deposit streams for various deposit zones, including direct condensation on equipment surfaces (Zone A), homogeneous particulate deposition (Zone B), and entrained fly ash deposition (Zone C); and physical removal of ash in cyclones based on D50 cut points. Another new feature of the CABRE III model is a user-friendly interface and detailed reports that are easily exportable into Word documents, Excel

  3. A center open to the public

    Science.gov (United States)

    Cuesta, L.; Vaquerizo, A.; García-Villadangos, M.

    2015-05-01

    The view to the public of a research center depends, of course, on the quality of its scientific activity but also, to a large extent, on the communication of results and spreading from the center itself. The Center for Astrobiology (CAB, CSIC-INTA) has maintained for some years a place among the leading Spanish scientific centers and the proof is his continued appearance in the media. In this communication we will give an overview of the activities of the Unit for Scientific Culture of CAB to achieve that goal.

  4. Patient-centered Radiology.

    Science.gov (United States)

    Itri, Jason N

    2015-10-01

    Patient-centered care (ie, care organized around the patient) is a model in which health care providers partner with patients and families to identify and satisfy patients' needs and preferences. In this model, providers respect patients' values and preferences, address their emotional and social needs, and involve them and their families in decision making. Radiologists have traditionally been characterized as "doctor-to-doctor" consultants who are distanced from patients and work within a culture that does not value patient centeredness. As medicine becomes more patient driven and the trajectory of health care is toward increasing patient self-reliance, radiologists must change the perception that they are merely consultants and become more active participants in patient care by embracing greater patient interaction. The traditional business model for radiology practices, which devalues interaction between patients and radiologists, must be transformed into a patient-centered model in which radiologists are reintegrated into direct patient care and imaging processes are reorganized around patients' needs and preferences. Expanding radiology's core assets to include direct patient care may be the most effective deterrent to the threat of commoditization. As the assault on the growth of Medicare spending continues, with medical imaging as a highly visible target, radiologists must adapt to the changing landscape by focusing on their most important consumer: the patient. This may yield substantial benefits in the form of improved quality and patient safety, reduced costs, higher-value care, improved patient outcomes, and greater patient and provider satisfaction. PMID:26466190

  5. INTEGRAL/JEM-X sees enhanced activity in the Galactic center region: SAX J1747.0-2853 and IGR J17454-2919

    DEFF Research Database (Denmark)

    Chenevez, Jérôme; Brandt, Søren; Budtz-Jørgensen, Carl;

    2014-01-01

    February 2012 (see, e.g., ATels #3183 and #3930). The measured fluxes are: 14 ± 1mCrab between 3-10 keV and 3.5 ± 2mCrab between 10-25 keV. In the same observation the new source IGR J17454-2919 (ATels #6530) and likely black hole candidate (ATel #6574) is also seen about a factor two brighter compared to......During INTEGRAL observations of the Galactic Center region performed between 2014 October 18 UTC 16:43 and Oct. 20 UTC 18:36, the JEM-X monitor has detected the transient source and X-ray superburster SAX J1747.0-2853 in a new outburst. The last time this source has been seen in outburst was in...

  6. Long-Term Demonstration of Hydrogen Production from Coal at Elevated Temperatures Year 6 - Activity 1.12 - Development of a National Center for Hydrogen Technology

    Energy Technology Data Exchange (ETDEWEB)

    Stanislowski, Joshua; Tolbert, Scott; Curran, Tyler; Swanson, Michael

    2012-04-30

    The Energy & Environmental Research Center (EERC) has continued the work of the National Center for Hydrogen Technology® (NCHT®) Program Year 6 Task 1.12 project to expose hydrogen separation membranes to coal-derived syngas. In this follow-on project, the EERC has exposed two membranes to coal-derived syngas produced in the pilot-scale transport reactor development unit (TRDU). Western Research Institute (WRI), with funding from the State of Wyoming Clean Coal Technology Program and the North Dakota Industrial Commission, contracted with the EERC to conduct testing of WRI’s coal-upgrading/gasification technology for subbituminous and lignite coals in the EERC’s TRDU. This gasifier fires nominally 200–500 lb/hour of fuel and is the pilot-scale version of the full-scale gasifier currently being constructed in Kemper County, Mississippi. A slipstream of the syngas was used to demonstrate warm-gas cleanup and hydrogen separation using membrane technology. Two membranes were exposed to coal-derived syngas, and the impact of coal-derived impurities was evaluated. This report summarizes the performance of WRI’s patent-pending coalupgrading/ gasification technology in the EERC’s TRDU and presents the results of the warm-gas cleanup and hydrogen separation tests. Overall, the WRI coal-upgrading/gasification technology was shown to produce a syngas significantly lower in CO2 content and significantly higher in CO content than syngas produced from the raw fuels. Warm-gas cleanup technologies were shown to be capable of reducing sulfur in the syngas to 1 ppm. Each of the membranes tested was able to produce at least 2 lb/day of hydrogen from coal-derived syngas.

  7. Concurrent engineering research center

    Science.gov (United States)

    Callahan, John R.

    1995-01-01

    The projects undertaken by The Concurrent Engineering Research Center (CERC) at West Virginia University are reported and summarized. CERC's participation in the Department of Defense's Defense Advanced Research Project relating to technology needed to improve the product development process is described, particularly in the area of advanced weapon systems. The efforts committed to improving collaboration among the diverse and distributed health care providers are reported, along with the research activities for NASA in Independent Software Verification and Validation. CERC also takes part in the electronic respirator certification initiated by The National Institute for Occupational Safety and Health, as well as in the efforts to find a solution to the problem of producing environment-friendly end-products for product developers worldwide. The 3M Fiber Metal Matrix Composite Model Factory Program is discussed. CERC technologies, facilities,and personnel-related issues are described, along with its library and technical services and recent publications.

  8. 基于时间驱动作业成本法的配送中心作业优化%Operation optimization of distribution center based on time-driven activity-based costing

    Institute of Scientific and Technical Information of China (English)

    杨华龙; 陈志俊; 计莹峰; 张燕

    2012-01-01

    In order to improve the operation,efficiency and effectiveness of distribution center,this paper analyzes the operation optimization problem of distribution center by using time-driven activity-based costing(TDABC).An operation optimization model is established with the objectives of decreasing the number of workers and increasing the rate of time efficiency in distribution center.And the constraints of operation in distribution center are optimized and controlled based on theory of constraint.The process and its steps of the optimization model are designed.Numerical examples show that the model and its optimization process are easy to implement and solve the problems,and the application results are quite well,which verifies the feasibility and validity of the model and its optimization process.%为提高配送中心作业的效率和效益,应用时间驱动作业成本法,对配送中心各作业优化问题进行分析.以降低配送中心作业员工数额和提高有效时间利用率为优化目标,建立配送中心作业优化模型,并依据约束理论对配送中心作业的约束进行优化控制,设计模型的优化流程步骤.数值实验分析结果表明,该模型及优化流程易于实施求解,应用效果良好,从而验证了模型及其优化流程的可行性和有效性.

  9. Day Care Centers

    Data.gov (United States)

    Department of Homeland Security — This database contains locations of day care centers for 50 states and Washington D.C. and Puerto Rico. The dataset only includes center based day care locations...

  10. Poison Control Centers

    Science.gov (United States)

    ... 1222 immediately. Name State American Association of Poison Control Centers Address AAPCC Central Office NOT A POISON ... not for emergency use. Arkansas ASPCA Animal Poison Control Center Address 1717 S. Philo Road, Suite 36 Urbana, ...

  11. New Mexico Convention Centers

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset provides an initial version of the locations of convention centers in New Mexico, in point form, with limited attributes, compiled using available data...

  12. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Education / Safety Education Centers En Español Carbon Monoxide Information Center The Invisible Killer Carbon monoxide, also known ... Install one and check its batteries regularly. View Information About CO Alarms Other CO Topics Safety Tips ...

  13. Hydrologic Engineering Center

    Data.gov (United States)

    Federal Laboratory Consortium — The Hydrologic Engineering Center (HEC), an organization within the Institute for Water Resources, is the designated Center of Expertise for the U.S. Army Corps of...

  14. RSW Cell Centered Grids

    Data.gov (United States)

    National Aeronautics and Space Administration — New cell centered grids are generated to complement the node-centered ones uploaded. Six tarballs containing the coarse, medium, and fine mixed-element and pure...

  15. ACTS data center

    Science.gov (United States)

    Syed, Ali; Vogel, Wolfhard J.

    1993-01-01

    Viewgraphs on ACTS Data Center status report are included. Topics covered include: ACTS Data Center Functions; data flow overview; PPD flow; RAW data flow; data compression; PPD distribution; RAW Data Archival; PPD Audit; and data analysis.

  16. NIH Clinical Centers

    Data.gov (United States)

    Federal Laboratory Consortium — The NIH Clinical Center consists of two main facilities: The Mark O. Hatfield Clinical Research Center, which opened in 2005, houses inpatient units, day hospitals,...

  17. Center for Functional Nanomaterials

    Data.gov (United States)

    Federal Laboratory Consortium — The Center for Functional Nanomaterials (CFN) explores the unique properties of materials and processes at the nanoscale. The CFN is a user-oriented research center...

  18. Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults.

    Science.gov (United States)

    Salaverria, Itziar; Philipp, Claudia; Oschlies, Ilske; Kohler, Christian W; Kreuz, Markus; Szczepanowski, Monika; Burkhardt, Birgit; Trautmann, Heiko; Gesk, Stefan; Andrusiewicz, Miroslaw; Berger, Hilmar; Fey, Miriam; Harder, Lana; Hasenclever, Dirk; Hummel, Michael; Loeffler, Markus; Mahn, Friederike; Martin-Guerrero, Idoia; Pellissery, Shoji; Pott, Christiane; Pfreundschuh, Michael; Reiter, Alfred; Richter, Julia; Rosolowski, Maciej; Schwaenen, Carsten; Stein, Harald; Trümper, Lorenz; Wessendorf, Swen; Spang, Rainer; Küppers, Ralf; Klapper, Wolfram; Siebert, Reiner

    2011-07-01

    The prognosis of germinal center-derived B-cell (GCB) lymphomas, including follicular lymphoma and diffuse large-B-cell lymphoma (DLBCL), strongly depends on age. Children have a more favorable outcome than adults. It is not known whether this is because of differences in host characteristics, treatment protocols, or tumor biology, including the presence of chromosomal alterations. By screening for novel IGH translocation partners in pediatric and adult lymphomas, we identified chromosomal translocations juxtaposing the IRF4 oncogene next to one of the immunoglobulin (IG) loci as a novel recurrent aberration in mature B-cell lymphoma. FISH revealed 20 of 427 lymphomas to carry an IG/IRF4-fusion. Those were predominantly GCB-type DLBCL or follicular lymphoma grade 3, shared strong expression of IRF4/MUM1 and BCL6, and lacked PRDM1/BLIMP1 expression and t(14;18)/BCL2 breaks. BCL6 aberrations were common. The gene expression profile of IG/IRF4-positive lymphomas differed from other subtypes of DLBCL. A classifier for IG/IRF4 positivity containing 27 genes allowed accurate prediction. IG/IRF4 positivity was associated with young age and a favorable outcome. Our results suggest IRF4 translocations to be primary alterations in a molecularly defined subset of GCB-derived lymphomas. The probability for this subtype of lymphoma significantly decreases with age, suggesting that diversity in tumor biology might contribute to the age-dependent differences in prognosis of lymphoma. PMID:21487109

  19. LEADER surveillance program results for 2006: an activity and spectrum analysis of linezolid using clinical isolates from the United States (50 medical centers).

    Science.gov (United States)

    Jones, Ronald N; Fritsche, Thomas R; Sader, Helio S; Ross, James E

    2007-11-01

    Surveillance for emerging linezolid resistance among commonly occurring Gram-positive pathogens in the United States began with the 2002 ZAAPS program and more recently (2004) expanded as the LEADER program. The 2006 LEADER program processed 5374 strains from 50 medical centers (100 per site) located within the 9 US census regions; species and number tested by broth microdilution (% linezolid susceptible) included Staphylococcus aureus (2913, >99.9), coagulase-negative staphylococci (CoNSs) (808, 98.4), enterococci (547, 97.4), Streptococcus pneumoniae (546, 100.0), viridans group streptococci (189, 100.0), and beta-hemolytic streptococci (371, 100.0). In addition to 1 linezolid-nonsusceptible S. aureus, 3 strains were daptomycin-nonsusceptible, 4 were quinupristin/dalfopristin-intermediate, 2 were vancomycin-intermediate (vancomycin MIC values, 4 mug/mL), and all were methicillin-resistant S. aureus. Among the linezolid-resistant isolates (1 S. aureus, 13 CoNSs, 3 Enterococcus faecalis, and 10 Enterococcus faecium isolates), all but 3 Staphylococcus epidermidis isolates had the G2567T mutation. Overall, 99.55% of the tested 2006 LEADER program isolates remained susceptible to linezolid at current Clinical and Laboratory Standards Institute breakpoints. PMID:17720350

  20. Hard X-ray Morphological and Spectral Studies of The Galactic Center Molecular Cloud Sgr B2: Constraining Past Sgr A* Flaring Activity

    CERN Document Server

    Zhang, Shuo; Mori, Kaya; Clavel, Maïca; Terrier, Régis; Ponti, Gabriele; Goldwurm, Andrea; Bauer, Franz E; Boggs, Steven E; Craig, William W; Christensen, Finn E; Harrison, Fiona A; Hong, Jaesub; Nynka, Melania; Stern, Daniel; Soldi, Simona; Tomsick, John A; Zhang, William W

    2015-01-01

    Galactic Center (GC) molecular cloud Sgr B2 is the best manifestation of an X-ray reflection nebula (XRN) reprocessing a past giant outburst from the supermassive black hole Sgr A*. Alternatively, Sgr B2 could be illuminated by low-energy cosmic ray electrons (LECRe) or protons (LECRp). In 2013, NuSTAR for the first time resolved Sgr B2 hard X-ray emission on sub-arcminute scales. Two prominent features are detected above 10 keV - a newly emerging cloud G0.66-0.13 and the central 90" radius region containing two compact cores Sgr B2(M) and Sgr B2(N) surrounded by diffuse emission. It is inconclusive whether the remaining level of Sgr B2 emission is still decreasing or has reached a constant background level. A decreasing Fe K$\\alpha$ emission can be best explained by XRN while a constant background emission can be best explained by LECRp. In the XRN scenario, the 3-79 keV Sgr B2 spectrum can well constrain the past Sgr A* outburst, resulting in an outburst spectrum with a peak luminosity of $L_{3-79\\rm~keV} \\...

  1. History of the Cretaceous Osbourn spreading center

    OpenAIRE

    Downey, Nathan J.; Stock, Joann M.; Clayton, Robert W.; Cande, Steven C.

    2007-01-01

    The Osbourn Trough is a fossil spreading center that rifted apart the Manihiki and Hikurangi Plateaus during Cretaceous time. Previous models of the Osbourn spreading center are based on data collected near the trough axis, and therefore only constrain the history of the Osbourn spreading center during the last few Ma of spreading. Our data set includes multibeam data collected northward to the Manihiki Plateau, allowing us to examine seafloor morphology created during the entire active perio...

  2. Student Perceptions of Learner-Centered Teaching

    OpenAIRE

    DeDe Wohlfarth; Daniel Sheras; Jessica L. Bennett; Bethany Simon; Jody H. Pimentel; Laura E. Gabel

    2008-01-01

    The learner-centered paradigm departs from traditional teaching models by focusing on students more than teachers and learning more than teaching. Thus, classes are more egalitarian; they emphasize critical thinking, active learning, and real-world assignments. Graduate students in learner-centered classrooms were surveyed about perceptions of their experiences in relation to the key dimensions of the learner-centered paradigm and noted that the approach contributed to their feeling respected...

  3. Center of buoyancy definition

    International Nuclear Information System (INIS)

    The center of buoyancy of an arbitrary shaped body is defined in analogy to the center of gravity. The definitions of the buoyant force and center of buoyancy in terms of integrals over the area of the body are converted to volume integrals and shown to have simple intuitive interpretations

  4. Center for Beam Physics, 1993

    International Nuclear Information System (INIS)

    The Center for Beam Physics is a multi-disciplinary research and development unit in the Accelerator and Fusion Research Division at Lawrence Berkeley Laboratory. At the heart of the Center's mission is the fundamental quest for mechanisms of acceleration, radiation and focusing of energy. Dedicated to exploring the frontiers of the physics of (and with) particle and photon beams, its primary mission is to promote the science and technology of the production, manipulation, storage and control systems of charged particles and photons. The Center serves this mission via conceptual studies, theoretical and experimental research, design and development, institutional project involvement, external collaborations, association with industry and technology transfer. This roster provides a glimpse at the scientists, engineers, technical support, students, and administrative staff that make up this team and a flavor of their multifaceted activities during 1993

  5. Is [FeO](2+) the active center also in iron containing zeolites? A density functional theory study of methane hydroxylation catalysis by Fe-ZSM-5 zeolite.

    Science.gov (United States)

    Rosa, Angela; Ricciardi, Giampaolo; Jan Baerends, Evert

    2010-04-19

    Arguments are put forward that the active alpha-oxygen site in the Fe-ZSM-5 catalyst consists of the FeO(2+) moiety. It is demonstrated that this zeolite site for FeO(2+) indeed obeys the design principles for high reactivity of the FeO(2+) moiety proposed earlier: a ligand environment consisting of weak equatorial donors (rather oxygen based than nitrogen based) and very weak or absent trans axial donor. The alpha-oxygen site would then owe its high reactivity to the same electronic structure features that lends FeO(2+) its high activity in biological systems, as well as in the classical Fenton chemistry. PMID:20302356

  6. Stennis Space Center celebrates Native American culture

    Science.gov (United States)

    2009-01-01

    Famie Willis (left), 2009-2010 Choctaw Indian Princess, displays artifacts during Native American Heritage Month activities at Stennis Space Center on Nov. 24. The celebration featured various Native American cultural displays for Stennis employees to view. Shown above are (l to r): Willis, Elaine Couchman of NASA Shared Services Center, John Cecconi of NSSC and Lakeisha Robertson of the Environmental Protection Agency.

  7. Student Perceptions of Learner-Centered Teaching

    Science.gov (United States)

    Wohlfarth, DeDe; Sheras, Daniel; Bennett, Jessica L.; Simon, Bethany; Pimentel, Jody H.; Gabel, Laura E.

    2008-01-01

    The learner-centered paradigm departs from traditional teaching models by focusing on students more than teachers and learning more than teaching. Thus, classes are more egalitarian; they emphasize critical thinking, active learning, and real-world assignments. Graduate students in learner-centered classrooms were surveyed about perceptions of…

  8. INIS National Center in Syria

    International Nuclear Information System (INIS)

    International Nuclear Information System (INIS) is the world's leading information system on the peaceful uses of nuclear science and technology and it is operated by the International Atomic Energy Agency (IAEA) in Vienna, Austria. An overview of INIS products, services, philosophy and operation is given. INIS hold a database containing over 2.5 million references increasing at approximately 85,000 references per year and a collection of full text non-conventional, or grey literature that would be hard to obtain elsewhere. In addition, the PC-based software for inputs preparation (WinFIBRE) is demonstrated. INIS national center in Syria is considered as a regional center for INIS inputs preparation. The center is responsible for selecting the relevant nuclear literature produced and published in Syria and preparing the national inputs and send them to INIS Secretariat to be included in the INIS database. The center also provides INIS services and products to users within Syria. Availability of INIS Database on CD-ROMs, which updated monthly, and the internet version, which updated weekly, and the NCL collections are also presented. Finally, translation activity of the center, such as INIS Booklet entitled Presenting INIS, and the INIS Thesaurus into Arabic were mentioned. This was an in-kind contribution from the Atomic Energy Commission of Syria to support the valuable work of the INIS and Nuclear Knowledge Management (NKM) section and will contribute significantly the dissemination of information among the researchers and scientists in the Arab Countries. (author)

  9. COMPUTATIONAL SCIENCE CENTER

    Energy Technology Data Exchange (ETDEWEB)

    DAVENPORT, J.

    2006-11-01

    Computational Science is an integral component of Brookhaven's multi science mission, and is a reflection of the increased role of computation across all of science. Brookhaven currently has major efforts in data storage and analysis for the Relativistic Heavy Ion Collider (RHIC) and the ATLAS detector at CERN, and in quantum chromodynamics. The Laboratory is host for the QCDOC machines (quantum chromodynamics on a chip), 10 teraflop/s computers which boast 12,288 processors each. There are two here, one for the Riken/BNL Research Center and the other supported by DOE for the US Lattice Gauge Community and other scientific users. A 100 teraflop/s supercomputer will be installed at Brookhaven in the coming year, managed jointly by Brookhaven and Stony Brook, and funded by a grant from New York State. This machine will be used for computational science across Brookhaven's entire research program, and also by researchers at Stony Brook and across New York State. With Stony Brook, Brookhaven has formed the New York Center for Computational Science (NYCCS) as a focal point for interdisciplinary computational science, which is closely linked to Brookhaven's Computational Science Center (CSC). The CSC has established a strong program in computational science, with an emphasis on nanoscale electronic structure and molecular dynamics, accelerator design, computational fluid dynamics, medical imaging, parallel computing and numerical algorithms. We have been an active participant in DOES SciDAC program (Scientific Discovery through Advanced Computing). We are also planning a major expansion in computational biology in keeping with Laboratory initiatives. Additional laboratory initiatives with a dependence on a high level of computation include the development of hydrodynamics models for the interpretation of RHIC data, computational models for the atmospheric transport of aerosols, and models for combustion and for energy utilization. The CSC was formed to

  10. Anti-karoshi activism in a corporate-centered society : medical, legal, and housewife activist collaborations in constructing death from overwork in Japan

    OpenAIRE

    Morioka, Rika

    2008-01-01

    The claim that excessive work can cause death is increasingly recognized in Japan, where over 10,000 victims are believed to die annually from karoshi, death from overworking. This study explores the process in which the issue of karoshi became a major social problem in 1990s and continues to be a source of legal disputes in Japan. Through a year long participant observation of anti -karoshi activism and over 120 in-depth interviews with medical and legal professionals, labor unions, victims'...

  11. Student Perceptions of Learner-Centered Teaching

    Directory of Open Access Journals (Sweden)

    DeDe Wohlfarth

    2008-08-01

    Full Text Available The learner-centered paradigm departs from traditional teaching models by focusing on students more than teachers and learning more than teaching. Thus, classes are more egalitarian; they emphasize critical thinking, active learning, and real-world assignments. Graduate students in learner-centered classrooms were surveyed about perceptions of their experiences in relation to the key dimensions of the learner-centered paradigm and noted that the approach contributed to their feeling respected as learners, developed their critical thinking skills, and encouraged their self-directedness. Based on these findings, post-secondary instructors are encouraged to experiment with learning-centered approaches to further explore this promising model.

  12. Chiral hydroxylation at the mononuclear nonheme Fe(II center of 4-(S hydroxymandelate synthase--a structure-activity relationship analysis.

    Directory of Open Access Journals (Sweden)

    Cristiana M L Di Giuro

    Full Text Available (S-Hydroxymandelate synthase (Hms is a nonheme Fe(II dependent dioxygenase that catalyzes the oxidation of 4-hydroxyphenylpyruvate to (S-4-hydroxymandelate by molecular oxygen. In this work, the substrate promiscuity of Hms is characterized in order to assess its potential for the biosynthesis of chiral α-hydroxy acids. Enzyme kinetic analyses, the characterization of product spectra, quantitative structure activity relationship (QSAR analyses and in silico docking studies are used to characterize the impact of substrate properties on particular steps of catalysis. Hms is found to accept a range of α-oxo acids, whereby the presence of an aromatic substituent is crucial for efficient substrate turnover. A hydrophobic substrate binding pocket is identified as the likely determinant of substrate specificity. Upon introduction of a steric barrier, which is suspected to obstruct the accommodation of the aromatic ring in the hydrophobic pocket during the final hydroxylation step, the racemization of product is obtained. A steady state kinetic analysis reveals that the turnover number of Hms strongly correlates with substrate hydrophobicity. The analysis of product spectra demonstrates high regioselectivity of oxygenation and a strong coupling efficiency of C-C bond cleavage and subsequent hydroxylation for the tested substrates. Based on these findings the structural basis of enantioselectivity and enzymatic activity is discussed.

  13. Postsynthetic Metal and Ligand Exchange in MFU-4l: A Screening Approach toward Functional Metal-Organic Frameworks Comprising Single-Site Active Centers.

    Science.gov (United States)

    Denysenko, Dmytro; Jelic, Jelena; Reuter, Karsten; Volkmer, Dirk

    2015-05-26

    The isomorphous partial substitution of Zn(2+) ions in the secondary building unit (SBU) of MFU-4l leads to frameworks with the general formula [M(x)Zn(5-x)Cl4(BTDD)3], in which x≈2, M = Mn(II), Fe(II), Co(II), Ni(II), or Cu(II), and BTDD = bis(1,2,3-triazolato-[4,5-b],[4',5'-i])dibenzo-[1,4]-dioxin. Subsequent exchange of chloride ligands by nitrite, nitrate, triflate, azide, isocyanate, formate, acetate, or fluoride leads to a variety of MFU-4l derivatives, which have been characterized by using XRPD, EDX, IR, UV/Vis-NIR, TGA, and gas sorption measurements. Several MFU-4l derivatives show high catalytic activity in a liquid-phase oxidation of ethylbenzene to acetophenone with air under mild conditions, among which Co- and Cu derivatives with chloride side-ligands are the most active catalysts. Upon thermal treatment, several side-ligands can be transformed selectively into reactive intermediates without destroying the framework. Thus, at 300 °C, Co(II)-azide units in the SBU of Co-MFU-4l are converted into Co(II)-isocyanate under continuous CO gas flow, involving the formation of a nitrene intermediate. The reaction of Cu(II)-fluoride units with H2 at 240 °C leads to Cu(I) and proceeds through the heterolytic cleavage of the H2 molecule.

  14. Carbon dioxide Information Analysis Center and World Data Center: A for Atmospheric trace gases. Annual progress report, FY 1994

    Energy Technology Data Exchange (ETDEWEB)

    Burtis, M.D. [comp.] [Tennessee Univ., Knoxville, TN (United States). Energy, Environment and Resources Center; Cushman, R.M.; Boden, T.A.; Jones, S.B.; Nelson, T.R.; Stoss, F.W. [Oak Ridge National Lab., TN (United States)

    1995-03-01

    This report summarizes the activities and accomplishments made by the Carbon Dioxide Information Analysis Center and World Data Center-A for Atmospheric Trace Gases during the fiscal year 1994. Topics discussed in this report include; organization and staff, user services, systems, communications, Collaborative efforts with China, networking, ocean data and activities of the World Data Center-A.

  15. National Center for Advancing Translational Sciences

    Science.gov (United States)

    ... activities. Licensing Opportunities NCATS makes it easy for industry and academia to interact and partner with Center laboratories and ... and Healthcare Products Regulatory Agency (“MHRA”) Designates VTS-270 as ...

  16. Center of excellence in laser medicine

    Energy Technology Data Exchange (ETDEWEB)

    Parrish, J.A.

    1992-01-01

    Achievements during the first six months of funding to prepare for a Center of Excellence in biomedical laser development include limited specific research projects within the Center's three broad interest areas, and program development to establish the Center and its activities. Progress in the three interest areas -- new medical laser systems development, optical diagnostics, and photosensitization, is reported. Feasibility studies and prototype development were emphasized, to enhance establishing a substantial Center through future support. Specific projects are an optimized laser-catheter system for reversal of vasospasm; optical detection of major skin burn depth and cancers using fluorescent drugs, and photosensitization of vascular tissues. In addition, an interdepartmental Laser Center was established at MGH to enhance collaborations and institutional committment to the Center of Excellence. Competitive postdoctoral research fellowships, with provision for matching funds from other departments, have been announced.

  17. Effect of weight-bearing activity on the center of rotation in the lower lumbar vertebrae%负重状态对下腰椎椎体间旋转中心的影响

    Institute of Scientific and Technical Information of China (English)

    刘佳男; 夏群; 苗军; 李宏达; 魏冬

    2016-01-01

    BACKGROUND:Epidemiologic reports have indicated that excessive weight-bearing exercise is one of important risk factors for lumbar degeneration, but the effects of weight-bearing activity on normal lumbar motion pattern are stil not clear. OBJECTIVE:To measure the changing characteristics and rules of position at the center of rotation of the lower lumbar spine during a weight-lifting activity of normal person. METHODS: Fourteen asymptomatic subjects with a mean age of (25±5) years were recruited for this study. The L4-5 and L5-S1 segments of each subject were CT-scanned to construct 3D models using dual X-ray imaging system and spiral CT examination combined technology in the aid of computer software. The physiological load and lumbar spinal 3D motion under the loading condition were reproduced when matching the flexion, neutrality and extension in the dual X-ray imaging system and on dual oblique lumbar X-ray image. Coordinate systems were established at the vertebral body of L4-S1 to obtain the center of rotation during flexion-to-neutral, neutral-to-extension and the ful flexion-extension motion. RESULTS AND CONCLUSION: (1) Under physiological load, the center of rotation of L4-5 of normal person was located about 1.0 mm anterior to the central axis of the vertebral body, and the center of rotation of L5-S1 was located about 0.7 mm anterior to the central axis of the vertebral body. (2) With weight loading, the center of rotation of both two segments shifted backward about 0.5 mm. There was no statistical difference between these two loading conditions. (3) When the center of rotation in flexion and extension was calculated respectively, the moving range of the center of rotation at both L4-5and L5-S1 became larger due to taking loads of 10 kg (P < 0.05). In flexion, the center of rotation at L5-S1 significantly shifted forward during a weight-lifting activity (P < 0.05). (4) These results confirm that compared with non-weight-bearing condition, the trajectory

  18. Modifications of laccase activities of copper efflux oxidase, CueO by synergistic mutations in the first and second coordination spheres of the type I copper center.

    Science.gov (United States)

    Kataoka, Kunishige; Kogi, Hiroki; Tsujimura, Seiya; Sakurai, Takeshi

    2013-02-15

    The redox potential of type I copper in the Escherichia coli multicopper oxidase CueO was shifted in the positive or negative direction as a result of the single, double, and triple mutations in the first and second coordination spheres: the formation of the NH···S(-)(Cys500 ligand) hydrogen bond, the breakdown of the NH(His443 ligand)···O(-)(Asp439) hydrogen bond, and the substitution of the Met510 ligand for the non-coordinating Leu or coordinating Gln. Laccase activities of CueO were maximally enhanced 140-fold by virtue of the synergistic effect of mild mutations at and at around the ligand groups to type I copper.

  19. Modifications of laccase activities of copper efflux oxidase, CueO by synergistic mutations in the first and second coordination spheres of the type I copper center.

    Science.gov (United States)

    Kataoka, Kunishige; Kogi, Hiroki; Tsujimura, Seiya; Sakurai, Takeshi

    2013-02-15

    The redox potential of type I copper in the Escherichia coli multicopper oxidase CueO was shifted in the positive or negative direction as a result of the single, double, and triple mutations in the first and second coordination spheres: the formation of the NH···S(-)(Cys500 ligand) hydrogen bond, the breakdown of the NH(His443 ligand)···O(-)(Asp439) hydrogen bond, and the substitution of the Met510 ligand for the non-coordinating Leu or coordinating Gln. Laccase activities of CueO were maximally enhanced 140-fold by virtue of the synergistic effect of mild mutations at and at around the ligand groups to type I copper. PMID:23337502

  20. 铁路局级客票系统双活架构的研究%Double active centers architecture of Ticketing and Reservation System for level of railway administration

    Institute of Scientific and Technical Information of China (English)

    徐东平; 李琪; 刘相坤; 李聚宝

    2015-01-01

    Generally, the Ticketing and Reservation System ( TRS ) for level of railway administration was arranged in the same server rooms, accordingly, the System worked under the pattern of single center. It meant that the continuity work of the System couldn’t be guaranteed if the environment of the server rooms were breakdown. This paper researched on the business, structure and relationship of data synchronization about the System. Combined with virtualization, a double active centers architecture of the System was designed. This architecture was with the advantages of high reliability, lfexible to expand and rapid processing capacity.%铁路局级客票系统目前部署于铁路局的同一物理机房,系统处于单中心运行状态,一旦机房环境出现故障,客票业务连续性难以保障。本文着重分析和研究铁路局级客票系统业务、结构和数据同步关系;结合虚拟化技术,设计了铁路局级客票系统双中心双活架构,该架构具备系统可靠性高、系统规模扩展灵活、系统处理能力快速等优点。

  1. Green Hill· Strolling: Design of Elderly Activity Center in Yijinhuoluoqi%绿丘·漫步——伊金霍洛旗老年活动中心设计

    Institute of Scientific and Technical Information of China (English)

    胡斌; 张明子; 张雅娟

    2012-01-01

    该文以伊金霍洛旗老年活动中心为例探讨了老年活动中心人性化的设计方法.以“绿丘·漫步”为设计理念,与场地条件、地域特征相契合.从场地设计、空间组织、功能排布、环境塑造、文脉表达等方面构建符合老年人身心健康需求特点和生活习性,同时兼顾地方文化与居住习惯、地域特点的文化家园,从而获得使用者的认同感和归属感.%The paper explores design techniques of activity center for aged people by the case of Yijinhuoluoqi. The design concept is "Green Hill · Strolling" and the architecture fits with site conditions and geographical features. The design aims to create a culture family that can satisfy the aged people's physical and psychological needs, as well as with consideration of local culture and living habits from the aspect of site designing, space organizing, function arranging, environment shaping, context expressing and so on. We hope this center can offer aged people sense of identity and belonging by the above way.

  2. Relativistic Guiding Center Equations

    Energy Technology Data Exchange (ETDEWEB)

    White, R. B. [PPPL; Gobbin, M. [Euratom-ENEA Association

    2014-10-01

    In toroidal fusion devices it is relatively easy that electrons achieve relativistic velocities, so to simulate runaway electrons and other high energy phenomena a nonrelativistic guiding center formalism is not sufficient. Relativistic guiding center equations including flute mode time dependent field perturbations are derived. The same variables as used in a previous nonrelativistic guiding center code are adopted, so that a straightforward modifications of those equations can produce a relativistic version.

  3. Chemical Security Analysis Center

    Data.gov (United States)

    Federal Laboratory Consortium — In 2006, by Presidential Directive, DHS established the Chemical Security Analysis Center (CSAC) to identify and assess chemical threats and vulnerabilities in the...

  4. Surgery center joint ventures.

    Science.gov (United States)

    Zasa, R J

    1999-01-01

    Surgery centers have been accepted as a cost effective, patient friendly vehicle for delivery of quality ambulatory care. Hospitals and physician groups also have made them the vehicles for coming together. Surgery centers allow hospitals and physicians to align incentives and share benefits. It is one of the few types of health care businesses physicians can own without anti-fraud and abuse violation. As a result, many surgery center ventures are now jointly owned by hospitals and physician groups. This article outlines common structures that have been used successfully to allow both to own and govern surgery centers.

  5. Electron Microscopy Center (EMC)

    Data.gov (United States)

    Federal Laboratory Consortium — The Electron Microscopy Center (EMC) at Argonne National Laboratory develops and maintains unique capabilities for electron beam characterization and applies those...

  6. Test Control Center (TCC)

    Data.gov (United States)

    Federal Laboratory Consortium — The Test Control Center (TCC) provides a consolidated facility for planning, coordinating, controlling, monitoring, and analyzing distributed test events. ,The TCC...

  7. Center for Deployment Psychology

    Data.gov (United States)

    Federal Laboratory Consortium — The Center for Deployment Psychology was developed to promote the education of psychologists and other behavioral health specialists about issues pertaining to the...

  8. Airline Operation Center Workstation

    Data.gov (United States)

    Department of Transportation — The Airline Operation Center Workstation (AOC Workstation) represents equipment available to users of the National Airspace system, outside of the FAA, that enables...

  9. Environmental Modeling Center

    Data.gov (United States)

    Federal Laboratory Consortium — The Environmental Modeling Center provides the computational tools to perform geostatistical analysis, to model ground water and atmospheric releases for comparison...

  10. Data Center at NICT

    Science.gov (United States)

    Ichikawa, Ryuichi; Sekido, Mamoru

    2013-01-01

    The Data Center at the National Institute of Information and Communications Technology (NICT) archives and releases the databases and analysis results processed at the Correlator and the Analysis Center at NICT. Regular VLBI sessions of the Key Stone Project VLBI Network were the primary objective of the Data Center. These regular sessions continued until the end of November 2001. In addition to the Key Stone Project VLBI sessions, NICT has been conducting geodetic VLBI sessions for various purposes, and these data are also archived and released by the Data Center.

  11. Small Business Development Center

    Data.gov (United States)

    Small Business Administration — Small Business Development Centers (SBDCs) provide assistance to small businesses and aspiring entrepreneurs throughout the United States and its territories. SBDCs...

  12. Solid Organ Transplantation in Patients with Inflammatory Bowel Diseases (IBD: Analysis of Transplantation Outcome and IBD Activity in a Large Single Center Cohort.

    Directory of Open Access Journals (Sweden)

    Fabian Schnitzler

    Full Text Available Currently, limited data of the outcome of inflammatory bowel disease (IBD in patients after solid organ transplantation (SOT are available. We aimed to analyze effects of SOT on the IBD course in a large IBD patient cohort.Clinical data from 1537 IBD patients were analyzed for patients who underwent SOT (n = 31 between July 2002 and May 2014. Sub-analyses included SOT outcome parameters, IBD activity before and after SOT, and efficacy of IBD treatment.4.74% of patients with ulcerative colitis (UC and 0.84% of patients with Crohn's disease (CD underwent SOT (p = 2.69 x 10(-6, UC vs. CD. 77.4% of patients with SOT underwent liver transplantation (LTx with tacrolimus-based immunosuppressive therapy after SOT. All LTx were due to primary sclerosing cholangitis (PSC or PSC overlap syndromes. Six patients (19.4% required renal transplantation and one patient (3.2% heart transplantation. A survival rate of 83.9% after a median follow-up period of 103 months was observed. Before SOT, 65.0% of patients were in clinical remission and 5 patients received immunosuppressive therapy (16.1%. After SOT, 61.0% of patients were in remission (p = 1.00 vs. before SOT and 29.0% required IBD-specific immunosuppressive or anti-TNF therapy (p = 0.54 vs. before SOT. 42.9% of patients with worsening of IBD after SOT were at higher risk of needing steroid therapy for increased IBD activity (p = 0.03; relative risk (RR: 10.29; 95% CI 1.26-84.06. Four patients (13.0% needed anti-TNF therapy after SOT (response rate 75%.SOT was more common in UC patients due to the higher prevalence of PSC-related liver cirrhosis in UC. Despite mainly tacrolimus-based immunosuppressive regimens, outcome of SOT and IBD was excellent in this cohort. In this SOT cohort, concomitant immunosuppressive therapy due to IBD was well tolerated.

  13. Ligand centered radical pathway in catechol oxidase activity with a trinuclear zinc-based model: Synthesis, structural characterization and luminescence properties

    Science.gov (United States)

    Pal, Sukanta; Chowdhury, Biswajit; Patra, Moumita; Maji, Milan; Biswas, Bhaskar

    2015-06-01

    A new trinuclear zinc(II) complex, [Zn3(L)(NCS)2](NO3)2·CH3OH·H2O (1), of a (N,O)-donor compartmental Schiff base ligand (H2L = N,N‧-bis(3-methoxysalicylidene)-1,3-diamino-2-propanol), has been synthesized in crystalline phase. The zinc(II) complex has been characterized by elemental analysis, IR spectroscopy, UV-Vis spectroscopy, powder X-ray diffraction study (PXRD), 1H NMR, EI mass spectrometry and thermogravimetric analysis. PXRD revealed that 1 crystallizes in P - 1 space group with a = 9.218 Å, b = 10.849 Å, c = 18.339 Å, with unit cell volume is 2179.713 (Å)3. Fluorescence spectra in methanolic solution reflect that intensity of emission for 1 is much higher compared to H2L and both the compounds exhibit good fluorescence properties. The complex 1 exhibits significant catalytic activities of biological relevance, viz. catechol oxidase. In methanol, it efficiently catalyzes the oxidation of 3,5-di-tert-butylcatechol (3,5-DTBC) to corresponding quinone via formation of a dinuclear species as [Zn2(L)(3,5-DTBC)]. Electron Paramagnetic Resonance (EPR) experiment suggests generation of radicals in the presence of 3,5-DTBC and it may be proposed that the radical pathway is probably responsible for conversion of 3,5-DTBC to 3,5-DTBQ promoted by complex of redox-innocent Zn(II) ion.

  14. [Securitization of the bi-site radiotherapy activity as part of the resumption of treatments in the Hospital of Epinal by the team of Alexis Vautrin Nancy Cancer Center].

    Science.gov (United States)

    Marchesi, V; Aigle, D; Peiffert, D; Noel, A; Simon, J-M

    2009-12-01

    In February 2007, the radiation therapy department of the Jean Monnet Hospital in Epinal (France) has stopped the radiotherapy treatments after the discovery of a radiotherapy accident and bad practices leading to overexposure of patients between 1987 and 2006. The Regional Cancer Center "Centre Alexis Vautrin" in Nancy (France) was given the task of the new start of treatment activity. From February 2007 to January 2008, actions of training, updates of equipments and practices have been performed in the Epinal Hospital, guided by the quality approach, allowing the treatment of new patients in February 2008, with the radiation oncologists and the medical physicists of the Centre Alexis Vautrin, with the highest conditions of security and confidence. PMID:19692280

  15. ROSAT Science Data Center

    Science.gov (United States)

    Murray, Stephen; Pisarski, Ryszard L. (Technical Monitor)

    2001-01-01

    This report provides a summary of the Smithsonian Astrophysical Observatory (SAO) ROSAT SCIENCE DATA CENTER (RSDC) activities for the recent years of our contract. Details have already been reported in the monthly reports. The SAO was responsible for the High Resolution Imager (HRI) detector on ROSAT. We also provided and supported the HRI standard analysis software used in the pipeline processing (SASS). Working with our colleagues at the Max Planck in Garching Germany (MPE), we fixed bugs and provided enhancements. The last major effort in this area was the port from VMS/VAX to VMS/ALPHA architecture. In 1998, a timing bug was found in the HRI standard processing system which degraded the positional accuracy because events accessed incorrect aspect solutions. The bug was fixed and we developed off-line correction routines and provided them to the community. The Post Reduction Off-line Software (PROS) package was developed by SAO and runs in the IRAF environment. Although in recent years PROS was not a contractual responsibility of the RSDC, we continued to maintain the system and provided new capabilities such as the ability to deal with simulated AXAF data in preparation for the NASA call for proposals for Chandra. Our most recent activities in this area included the debugging necessary for newer versions of IRAF which broke some of our software. At SAO we have an operating version of PROS and hope to release a patch even though almost all functionality that was lost was subsequently recovered via an IRAF patch (i.e. most of our problems were caused by an IRAF bug).

  16. Assemblies of a new flexible multicarboxylate ligand and d10 metal centers toward the construction of homochiral helical coordination polymers: structures, luminescence, and NLO-active properties.

    Science.gov (United States)

    Zang, Shuangquan; Su, Yang; Li, Yizhi; Ni, Zhaoping; Meng, Qingjin

    2006-01-01

    Hydro(solvo)thermal reactions between a new flexible multicarboxylate ligand of 2,2',3,3'-oxydiphthalic acid (2,2',3,3'-H(4)ODPA) and M(NO(3))(2).xH(2)O (M = Zn, x = 6; M = Cd, x = 4) in the presence of 4,4'-bipyridine (bpy) afford two novel homochiral helical coordination polymers [[Zn(2)(2,2',3,3'-ODPA)(bpy)(H(2)O)(3)].(H(2)O)(2) for 1 and [Cd(2)(2,2',3,3'-ODPA)(bpy)(H(2)O)(3)].(H(2)O)(2) for 2]. Though having almost the same chemical formula, they have different space groups (P2(1)2(1)2(1) for 1 and P2(1) for 2) and different bridging modes of the 2,2',3,3'-ODPA ligand. Two kinds of homochiral helices (right-handed) are found in both 1 and 2, each of which discriminates only one kind of crystallographical nonequivalent metal atom. 1 has a 2D metal-organic framework and can be seen as the unity of two parallel homochiral Zn1 and Zn2 helices, in which the nodes are etheric oxygen atoms. In contrast, 2 has a 3D metal-organic framework and consists of two partially overlapped homochiral Cd1 and Cd2 helices in the two dimensions. Moreover, metal-ODPA helices give a 2D chiral herringbone structural motif in both 1 and 2 in the two dimensions, which are further strengthened by the second ligand of bpy. Bulk materials for 1 and 2 all have good second-harmonic generation activity, approximately 1 and 0.8 times that of urea.

  17. Survival of AIDS patients and characteristics of those who died over eight years of highly active antiretroviral therapy, at a referral center in northeast Brazil

    Directory of Open Access Journals (Sweden)

    Ladjane Santos Wolmer de Melo

    2008-08-01

    Full Text Available Introduction of highly active antiretroviral therapy has resulted in a significant reduction in morbimortality and significant changes in the causes of death among HIV/AIDS patients. For this reason, it has become essential to monitor survival and causes of death. We constructed a survival curve based on 597 adult patients notified as AIDS cases between 1997 and 2004, at the Hospital das Clínicas, Federal University of Pernambuco, Recife, Brazil. Among those patients, 150 (25% progressed to death by December, 2005. Of these, 119 were studied in detail. The data were collected from notification files of the State Health Department and the State Mortality Information System, and were complemented by analysis of medical records. These 597 patients had a survival rate of 88%, 86% and 82% after one, two and five years, respectively, and a 75% likelihood of surviving to 1,984 days (66 months. Most of the deaths occurred during the first months after the diagnosis (median, 129 days. Patients who died were predominantly young men who had sexual exposure and came from Recife (the state capital or its metropolitan region. When the patients were first seen, a large proportion had already presented severe signs of immunodeficiency. Comparing the patients within this group, the characteristics that were associated with lower survival were: male sex, hemoglobin < 10 mg/dL, lymphocytes < 1,000/mm³, use of fewer therapeutic drugs and antiretroviral regimens and non-introduction of protease inhibitors. Most of them died from AIDS-related diseases, particularly undefined respiratory infections.

  18. Annual report on the activities of National Reference Centers established on the basis of regional public health authorities of the Slovak Republic and the Office of Public Health of the Slovak Republic in 2008

    International Nuclear Information System (INIS)

    A brief account of activities carried out by the National Reference Centers (NRC) established on the basis of regional public health authorities of the Slovak Republic and the Office of Public Health of the Slovak Republic in 2008 is presented. These activities are reported under the headings: (1) NRC for influenza; (2) NRC for arbovirus and hemorrhagic fever; (3) NRC for poliomyelitis; (4) NRC for meningococci; (5) NRC to monitor the resistance of microorganisms to antibiotics; (6) NRC for evaluation of late effects of chemical substances, methods of genetic toxicology; (7) NRC for hydrobiology; (8) NRC for ecotoxicology; (9) NRC for non-ionizing radiation; (10) NRC for hydrothermal microclimate; (11) NRC for exposure tests xenobiotics; (12) NRC for morbilli, rubella and parotitis; (13) NRC for environmental microbiology; (14) NRC on pesticide residues; (15) NRC for salmonella; (16) NRC for microbial autovaccines; (17) NRC health issues for urban air pollution; (18) NRC for noise and vibration; (19) Information Center for bacteriological (biological) and toxin weapons; (20) NRC for impact assessment of ambient air and air of enclosed spaces non-productive nature of population health; (21) NRC for toxoplasmosis; (22) NRC for exposure assessment and health risk; (23) NRC for pertussis and parapertussis; (24) NRC for syphilis; (25) NRC for hygienic drinking water problems; (26) NRC for listeriosis; (27) NRC for intestinal parasitosis; (28) NRC for diphtheria; (29) NRC for vibrionaceae; (30) NRC for environmental mycology; (31) NRC issues for fibrous dusts; (32) NRC for thermotolerant amoebae; (33) NRC issues for coal mines; (34) NRC for packaging materials; (35) NRC for haemophilus infections; (36) NRC for Legionella.

  19. Annual report on the activities of National Reference Centers established on the basis of regional public health authorities of the Slovak Republic and the Office of Public Health of the Slovak Republic in 2009

    International Nuclear Information System (INIS)

    A brief account of activities carried out by the National Reference Centers (NRC) established on the basis of regional public health authorities of the Slovak Republic and the Office of Public Health of the Slovak Republic in 2009 is presented. These activities are reported under the headings: (1) NRC for influenza; (2) NRC for arbovirus and hemorrhagic fever; (3) NRC for poliomyelitis; (4) NRC for meningococci; (5) NRC to monitor the resistance of microorganisms to antibiotics; (6) NRC for evaluation of late effects of chemical substances, methods of genetic toxicology; (7) NRC for hydrobiology; (8) NRC for ecotoxicology; (9) NRC for non-ionizing radiation; (10) NRC for hydrothermal microclimate; (11) NRC for exposure tests xenobiotics; (12) NRC for morbilli, rubella and parotitis; (13) NRC for environmental microbiology; (14) NRC on pesticide residues; (15) NRC for salmonella; (16) NRC health issues for urban air pollution; (17) NRC for microbial autovaccines; (18) NRC for noise and vibration; (19) Information Center for bacteriological (biological) and toxin weapons; (20) NRC for impact assessment of ambient air and air of enclosed spaces non-productive nature of population health; (21) NRC for toxoplasmosis; (22) NRC for exposure assessment and health risk; (23) NRC for pertussis and parapertussis; (24) NRC for syphilis; (25) NRC for hygienic drinking water problems; (26) NRC for listeriosis; (27) NRC for intestinal parasitosis; (28) NRC for diphtheria; (29) NRC for vibrionaceae; (30) NRC for environmental mycology; (31) NRC issues for fibrous dusts; (32) NRC for thermotolerant amoebae; (33) NRC issues for coal mines; (34) NRC for articles of daily use and packing materials; (35) NRC for haemophilus infections; (36) NRC for Legionella in the environment.

  20. Funding Opportunity: Genomic Data Centers

    Science.gov (United States)

    Funding Opportunity CCG, Funding Opportunity Center for Cancer Genomics, CCG, Center for Cancer Genomics, CCG RFA, Center for cancer genomics rfa, genomic data analysis network, genomic data analysis network centers,

  1. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Consumers Businesses Contact CPSC Website Design Feedback Consumers: Español Businesses: Español , 中文 , Tiếng Việt Connect with Us : Twitter YouTube ... Safely Home / Safety Education / Safety Education Centers En Español Carbon Monoxide Information Center The Invisible Killer Carbon ...

  2. Center for Women Veterans

    Science.gov (United States)

    ... VA » Center for Women Veterans (CWV) Center for Women Veterans (CWV) 10/27/2016 #VeteranOfTheDay Army Veteran ... Meet the Veteran of the Day » Employment and Women Veterans An interview with the Women Veteran Program ...

  3. Call Center Capacity Planning

    DEFF Research Database (Denmark)

    Nielsen, Thomas Bang

    The main topics of the thesis are theoretical and applied queueing theory within a call center setting. Call centers have in recent years become the main means of communication between customers and companies, and between citizens and public institutions. The extensively computerized infrastructu...

  4. NASA propagation information center

    Science.gov (United States)

    Smith, Ernest K.; Flock, Warren L.

    1990-07-01

    The NASA Propagation Information Center became formally operational in July 1988. It is located in the Department of Electrical and Computer Engineering of the University of Colorado at Boulder. The center is several things: a communications medium for the propagation with the outside world, a mechanism for internal communication within the program, and an aid to management.

  5. Relative Lyapunov Center Bifurcations

    DEFF Research Database (Denmark)

    Wulff, Claudia; Schilder, Frank

    2014-01-01

    Relative equilibria (REs) and relative periodic orbits (RPOs) are ubiquitous in symmetric Hamiltonian systems and occur, for example, in celestial mechanics, molecular dynamics, and rigid body motion. REs are equilibria, and RPOs are periodic orbits of the symmetry reduced system. Relative Lyapunov...... center bifurcations are bifurcations of RPOs from REs corresponding to Lyapunov center bifurcations of the symmetry reduced dynamics. In this paper we first prove a relative Lyapunov center theorem by combining recent results on the persistence of RPOs in Hamiltonian systems with a symmetric Lyapunov...... center theorem of Montaldi, Roberts, and Stewart. We then develop numerical methods for the detection of relative Lyapunov center bifurcations along branches of RPOs and for their computation. We apply our methods to Lagrangian REs of the N-body problem....

  6. Energy efficient data centers

    Energy Technology Data Exchange (ETDEWEB)

    Tschudi, William; Xu, Tengfang; Sartor, Dale; Koomey, Jon; Nordman, Bruce; Sezgen, Osman

    2004-03-30

    Data Center facilities, prevalent in many industries and institutions are essential to California's economy. Energy intensive data centers are crucial to California's industries, and many other institutions (such as universities) in the state, and they play an important role in the constantly evolving communications industry. To better understand the impact of the energy requirements and energy efficiency improvement potential in these facilities, the California Energy Commission's PIER Industrial Program initiated this project with two primary focus areas: First, to characterize current data center electricity use; and secondly, to develop a research ''roadmap'' defining and prioritizing possible future public interest research and deployment efforts that would improve energy efficiency. Although there are many opinions concerning the energy intensity of data centers and the aggregate effect on California's electrical power systems, there is very little publicly available information. Through this project, actual energy consumption at its end use was measured in a number of data centers. This benchmark data was documented in case study reports, along with site-specific energy efficiency recommendations. Additionally, other data center energy benchmarks were obtained through synergistic projects, prior PG&E studies, and industry contacts. In total, energy benchmarks for sixteen data centers were obtained. For this project, a broad definition of ''data center'' was adopted which included internet hosting, corporate, institutional, governmental, educational and other miscellaneous data centers. Typically these facilities require specialized infrastructure to provide high quality power and cooling for IT equipment. All of these data center types were considered in the development of an estimate of the total power consumption in California. Finally, a research ''roadmap'' was developed

  7. User-centered design

    International Nuclear Information System (INIS)

    The simplification philosophy, as an example, that both of EPRI-URD and EUR emphasize is treated mostly for the cost reduction of the nuclear power plants, but not for the simplification of the structure of user's tasks, which is one of the principles of user-centered design. A user-centered design is a philosophy based on the needs and interests of the user, with an emphasis on making products usable and understandable. However, the nuclear power plants offered these days by which the predominant reactor vendors are hardly user-centered but still designer-centered or technology-centered in viewpoint of fulfilling user requirements. The main goal of user-centered design is that user requirements are elicited correctly, reflected properly into the system requirements, and verified thoroughly by the tests. Starting from the user requirements throughout to the final test, each requirement should be traceable. That's why requirement traceability is a key to the user-centered design, and main theme of a requirement management program, which is suggested to be added into EPRI-URD and EUR in the section of Design Process. (author)

  8. Structure refinement and one-center luminescence of Eu{sup 3+} activated ZnBi{sub 2}B{sub 2}O{sub 7} under UV excitation

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Liwei; Zhang, Fangxin [The MOE Key Laboratory of Weak-Light Nonlinear Photonics, School of Physics, Nankai University, Tianjin 300071 (China); Wu, Li, E-mail: lwu@nankai.edu.cn [The MOE Key Laboratory of Weak-Light Nonlinear Photonics, School of Physics, Nankai University, Tianjin 300071 (China); Yi, Huan [The MOE Key Laboratory of Weak-Light Nonlinear Photonics, School of Physics, Nankai University, Tianjin 300071 (China); Wang, Hongrun [Institute of Photo-electronic Thin Film Devices and Technology, Tianjin Key Laboratory of Photo-electronic Thin Film Devices and Technology, and Key Laboratory of Optoelectronic Information Science and Technology, Ministry of Education, Nankai University, Tianjin 300071 (China); Zhang, Yi, E-mail: yizhang@nankai.edu.cn [Institute of Photo-electronic Thin Film Devices and Technology, Tianjin Key Laboratory of Photo-electronic Thin Film Devices and Technology, and Key Laboratory of Optoelectronic Information Science and Technology, Ministry of Education, Nankai University, Tianjin 300071 (China); Kong, Yongfa; Xu, Jingjun [The MOE Key Laboratory of Weak-Light Nonlinear Photonics, School of Physics, Nankai University, Tianjin 300071 (China)

    2015-11-05

    A series of Eu{sup 3+}-activated red phosphors ZnBi{sub 2}B{sub 2}O{sub 7}:xEu{sup 3+} were synthesized by high temperature solid-state reaction method. Rietveld refinement on the powder X-ray diffraction (XRD) data was performed to study the local crystal environment of Eu{sup 3+} in ZnBi{sub 2}B{sub 2}O{sub 7} host. The refinement results disclose that the doped Eu{sup 3+} do not change the host structure. Although two different cation sites are available, the doped Eu{sup 3+} is inclined to occupy Zn site instead of Bi site. This indicates that there is only one luminescent center when Eu{sup 3+} is doped into ZnBi{sub 2}B{sub 2}O{sub 7} phosphor, which is further confirmed by the luminescence properties of ZnBi{sub 2}B{sub 2}O{sub 7}:xEu{sup 3+}. The influences of the doping concentration and the excitation wavelength on the one-center luminescence of Eu{sup 3+} in ZnBi{sub 2}B{sub 2}O{sub 7} are discussed along with the decay characteristics. Based on the temperature-dependent PL spectra, the fast decrease of emission intensity with the increase of temperature is due to the non-radiative relaxation. - Highlights: • New red-emitting ZnBi{sub 2}B{sub 2}O{sub 7}:xEu{sup 3+} phosphors excited by near ultraviolet light were synthesized. • The doped Eu{sup 3+} prefers to occupy Zn{sup 2+} site and there is only one-center luminescence of Eu{sup 3+} in ZnBi{sub 2}B{sub 2}O{sub 7} host. • CIE coordinates are very much closer to that of standard red light (0.67, 0.33)

  9. Understanding wellness center loyalty through lifestyle analysis.

    Science.gov (United States)

    Suresh, Satya; Ravichandran, Swathi; P, Ganesan

    2011-01-01

    Many changes taking place at a macro-level in Indian society along with the popularity of services that are native to India, such as Yoga and Ayurveda, have generated significant interest in wellness services. To assist wellness centers in gaining loyal clients, the goal of this study was to understand the influence of customer lifestyle factors on wellness center loyalty. The activities, interests, and opinions model was used to understand the lifestyles of wellness center clients. Data were collected from clients of five wellness centers. Regression results indicate that overworked individuals and those seeking a balance between work and family life would be the most loyal to wellness centers. Managerial implications of results are discussed. PMID:21347940

  10. Reliability Centered Maintenance - Methodologies

    Science.gov (United States)

    Kammerer, Catherine C.

    2009-01-01

    Journal article about Reliability Centered Maintenance (RCM) methodologies used by United Space Alliance, LLC (USA) in support of the Space Shuttle Program at Kennedy Space Center. The USA Reliability Centered Maintenance program differs from traditional RCM programs because various methodologies are utilized to take advantage of their respective strengths for each application. Based on operational experience, USA has customized the traditional RCM methodology into a streamlined lean logic path and has implemented the use of statistical tools to drive the process. USA RCM has integrated many of the L6S tools into both RCM methodologies. The tools utilized in the Measure, Analyze, and Improve phases of a Lean Six Sigma project lend themselves to application in the RCM process. All USA RCM methodologies meet the requirements defined in SAE JA 1011, Evaluation Criteria for Reliability-Centered Maintenance (RCM) Processes. The proposed article explores these methodologies.

  11. National Farm Medicine Center

    Science.gov (United States)

    Research Areas Applied Sciences Biomedical Informatics Clinical Research Epidemiology Farm Medicine Human Genetics Oral-Systemic Health Clinical ... Consulting Agritourism Farm MAPPER Lyme Disease ROPS Rebate Zika Virus National Farm Medicine Center The National Farm ...

  12. Cooperative Tagging Center (CTC)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Cooperative Tagging Center (CTC) began as the Cooperative Game Fish Tagging Program (GTP) at Woods Hole Oceanographic Institute (WHOI) in 1954. The GTP was...

  13. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Chairman Commissioners Contact Information Agency Reports Legislative Affairs Job Opportunities Inspector General Safety Guides Safety Education Centers OnSafety Blog Neighborhood Safety Network Community Outreach ...

  14. FEMA Disaster Recovery Centers

    Data.gov (United States)

    Department of Homeland Security — This is a search site for FEMA's Disaster Recovery Centers (DRC). A DRC is a readily accessible facility or mobile office set up by FEMA where applicants may go for...

  15. Health Center Controlled Network

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Health Center Controlled Network (HCCN) tool is a locator tool designed to make data and information concerning HCCN resources more easily available to our...

  16. Centering in Japanese Discourse

    CERN Document Server

    Walker, M; Côté, S; Walker, Marilyn; Iida, Masayo; Cote, Sharon

    1996-01-01

    In this paper we propose a computational treatment of the resolution of zero pronouns in Japanese discourse, using an adaptation of the centering algorithm. We are able to factor language-specific dependencies into one parameter of the centering algorithm. Previous analyses have stipulated that a zero pronoun and its cospecifier must share a grammatical function property such as {\\sc Subject} or {\\sc NonSubject}. We show that this property-sharing stipulation is unneeded. In addition we propose the notion of {\\sc topic ambiguity} within the centering framework, which predicts some ambiguities that occur in Japanese discourse. This analysis has implications for the design of language-independent discourse modules for Natural Language systems. The centering algorithm has been implemented in an HPSG Natural Language system with both English and Japanese grammars.

  17. HUD Homeownership Centers

    Data.gov (United States)

    Department of Housing and Urban Development — HUD Homeownership Centers (HOCs) insure single family Federal Housing Administration (FHA) mortgages and oversee the selling of HUD homes. FHA has four...

  18. Accredited Birth Centers

    Science.gov (United States)

    ... 717-933-9743 Accredited since January 2016 100 Bright Eyes Midwifery and Wild Rivers Women's Health Accredited ... Birthing Center-Cedar Park Accredited 1130 Cottonwood Creek Trail Building D Suite 2 Cedar Park, TX 78613 ...

  19. ADVANCED DATA CENTER ECONOMY

    OpenAIRE

    Sukhov, R.; Amzarakov, M.; Isaev, E.

    2013-01-01

    The article addresses basic Data Centers (DC) drivers of price and engineering, which specify rules and price evaluation for creation and further operation. DC energy efficiency concept, its influence on DC initial price, operation costs and Total Cost of Ownership.

  20. National Automotive Center - NAC

    Data.gov (United States)

    Federal Laboratory Consortium — Encouraged by the advantages of collaboration, the U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC) worked with the Secretary of the...

  1. World Trade Center

    Index Scriptorium Estoniae

    2006-01-01

    Esilinastus katastroofifilm "World Trade Center" : stsenarist Andrea Berloff : režissöör Oliver Stone : kunstnik Jan Roelfs : osades Nicholas Cage, Michael Pena, Stephen Dorff jpt : Ameerika Ühendriigid 2006. Ka filmi prototüüpidest

  2. Center for Contaminated Sediments

    Data.gov (United States)

    Federal Laboratory Consortium — The U.S. Army Corps of Engineers Center for Contaminated Sediments serves as a clearinghouse for technology and expertise concerned with contaminated sediments. The...

  3. USU Patient Simulation Center

    Data.gov (United States)

    Federal Laboratory Consortium — he National Capital Area (NCA) Medical Simulation Center is a state-of-the-art training facility located near the main USU campus. It uses simulated patients (i.e.,...

  4. Hazardous Waste Research Center

    Data.gov (United States)

    Federal Laboratory Consortium — A full-service research and evaluation center equipped with safety equipment, a high-bay pilot studies area, and a large-scale pilot studies facility The U.S. Army...

  5. Advanced Missile Signature Center

    Data.gov (United States)

    Federal Laboratory Consortium — The Advanced Missile Signature Center (AMSC) is a national facility supporting the Missile Defense Agency (MDA) and other DoD programs and customers with analysis,...

  6. CNPC International Research Center

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ CNPC International Research Center (CNPCIRC), jointly managed by CNODC and RIPED of China National Petroleum Corporation (CNPC), was established in 1999 for providing technical research support to all the overseas oil and gas projects of CNPC.

  7. Physical Oceanography Distributed Active Archive Center

    Science.gov (United States)

    Benada, J. Robert

    1997-01-01

    This new TOPEX/POSEIDON product provides the full mission data set in a new format with many data quality improvements brought about by the work of many scientists during the mission. It is a revised form to the MGDR-A CD-ROM set which covered data from the beginning of the mission, Septermber 22, 1992 to April 23, 1996.

  8. Active Center of Islamic Dialogue Civilizations

    Directory of Open Access Journals (Sweden)

    Ebrahim Moghimi

    2005-01-01

    Full Text Available It is obvious that an essay have introduced about Dialogue Civilizations, at first must be start with a definition about it. Obviously, this simple definition is almost difficult. Defining of Dialogue Civilizations is complex and difficult as far as it need to a vast range of definitions. In this essay will argue that how ever definition of Dialogue Civilization is different, can only seek as specific of intemporall and special situations that are in real-life. As well as this essay emphasize to practice of environmental (realm in Islamic countries. The philosophy of this essay is that, what is the share of Islamic environments with regard to looking at Civilizations special phenomena. The first attitude is that Islamic civilization includes different spaces around the globe. The second attitude is that Islamic Civilization includes developing of other Civilizations realm. The third is that in the realm of Islamic Civilization live different human life and this is an important starting point for Cultural Dialogue in the Islamic countries together. The fourth is that, there are expanding (space, population, political systems, organs and economic is different, that we will describe them in this essay.

  9. The John Wesley Powell Center for Analysis and Synthesis

    Science.gov (United States)

    Baron, Jill; Goldhaber, Martin

    2011-01-01

    The Powell Center provides an environment for cross-disciplinary scientific collaboration. The Center expands U.S. Geological Survey earth system science synthesis research activities by fostering the innovation that results from accumulated knowledge, constructive errors, and the "information spillover" that emerges from collaborative settings. Working Groups at the Powell Center use existing data to produce new knowledge..

  10. The Galactic Center

    OpenAIRE

    R. Genzel; Karas, V.

    2007-01-01

    In the past decade high resolution measurements in the infrared employing adaptive optics imaging on 10m telescopes have allowed determining the three dimensional orbits stars within ten light hours of the compact radio source at the center of the Milky Way. These observations show the presence of a three million solar mass black hole in Sagittarius A* beyond any reasonable doubt. The Galactic Center thus constitutes the best astrophysical evidence for the existence of black holes which have ...

  11. Oil Reserve Center Established

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Like other countries,China has started to grow its strategic oil reserve in case oil supplies are cut On December 18,2007,the National Development and Reform Commission(NDRC),China’s top economic planner,announced that the national oil reserve center has been officially launched.The supervisory system over the oil reserves has three levels: the energy department of the NDRC,the oil reserve center,and the reserve bases.

  12. Human Centered Hardware Modeling and Collaboration

    Science.gov (United States)

    Stambolian Damon; Lawrence, Brad; Stelges, Katrine; Henderson, Gena

    2013-01-01

    In order to collaborate engineering designs among NASA Centers and customers, to in clude hardware and human activities from multiple remote locations, live human-centered modeling and collaboration across several sites has been successfully facilitated by Kennedy Space Center. The focus of this paper includes innovative a pproaches to engineering design analyses and training, along with research being conducted to apply new technologies for tracking, immersing, and evaluating humans as well as rocket, vehic le, component, or faci lity hardware utilizing high resolution cameras, motion tracking, ergonomic analysis, biomedical monitoring, wor k instruction integration, head-mounted displays, and other innovative human-system integration modeling, simulation, and collaboration applications.

  13. Neutral Atomic Carbon in Centers of Galaxies

    OpenAIRE

    Israel, F.P.; Baas, F

    2001-01-01

    We present measurements of the emission from the centers of fifteen spiral galaxies in the 3P1-3P0 [CI] fine-structure transition at 492 GHz. Observed galaxy centers range from quiescent to starburst to active. The intensities of neutral carbon, the J=2-1 transition of 13CO and the J=4-3 transition of 12CO are compared in matched beams. Most galaxy centers emit more strongly in [CI] than in 13CO, completely unlike the situation pertaining to Galactic molecular cloud regions. [CI] intensities ...

  14. Microsoft System Center 2012 Orchestrator cookbook

    CERN Document Server

    Erskine, Samuel

    2013-01-01

    This book is written in a practical, Cookbook style with numerous chapters and recipes focusing on creating runbooks to automate mission critical and everyday administration tasks.System Center 2012 Orchestrator is for administrators who wish to simplify the process of automating systems administration tasks. This book assumes that you have a basic knowledge of Windows Server 2008 Administration, Active Directory, Network Systems, and Microsoft System Center technologies.

  15. [Theater in Brazilian science museums and centers].

    Science.gov (United States)

    Moreira, Leonardo Maciel; Marandino, Martha

    2015-12-01

    This qualitative research, based on a descriptive and exploratory study, examines how theater is used as a science communication strategy by Brazilian science museums and centers. Data was collected through a survey emailed to 24 Brazilian institutions identified as science museums and centers. Content analysis was performed, using cross-sectional thematic analysis. It was found that respondents' activities could be classified as approaching theater as an educational support.

  16. Activities.

    Science.gov (United States)

    Moody, Mally

    1992-01-01

    A series of four activities are presented to enhance students' abilities to appreciate and use trigonometry as a tool in problem solving. Activities cover problems applying the law of sines, the law of cosines, and matching equivalent trigonometric expressions. A teacher's guide, worksheets, and answers are provided. (MDH)

  17. Air Risk Information Support Center

    Energy Technology Data Exchange (ETDEWEB)

    Shoaf, C.R.; Guth, D.J. [Environmental Protection Agency, Washington, DC (United States)

    1990-12-31

    The Air Risk Information Support Center (Air RISC) was initiated in early 1988 by the US Environmental Protection Agency`s (EPA) Office of Health and Environmental Assessment (OHEA) and the Office of Air Quality Planning and Standards (OAQPS) as a technology transfer effort that would focus on providing information to state and local environmental agencies and to EPA Regional Offices in the areas of health, risk, and exposure assessment for toxic air pollutants. Technical information is fostered and disseminated by Air RISCs three primary activities: (1) a {open_quotes}hotline{close_quotes}, (2) quick turn-around technical assistance projects, and (3) general technical guidance projects. 1 ref., 2 figs.

  18. NASA InterCenter Collaboration Increases ROI

    Science.gov (United States)

    Lankford, Kimberly; Best, Susan; Felton, Larry; Newhouse, Marilyn

    2012-01-01

    Funding for National Aeronautics and Space Administration (NASA) space mission operations is tighter than ever in the current environment of federal government deficit reductions. Conventional wisdom would expect this environment to drive increasing competition between NASA centers for the limited available funds. However, recent inter-center activities at the Huntsville Operations Support Center (HOSC) at NASA's Marshall Space Flight Center emphasize collaboration rather than competition and demonstrate the value of partnerships to increase the return on shrinking investments. These efforts cover a variety of activities and potential returns. To facilitate sharing data from test and verification through operations without levying requirements on data format or software tools, the HOSC is working with multiple centers on an evolutionary path toward a distributed data architecture and archive. The approach reduces the required investment by allowing the partners to reuse their existing formats and tools, while facilitating gone ]stop h user visibility into and controlled access to the full complement of data regardless of user or data location. The HOSC is also working on two activities to promote sharing operations implementations and leveraging the experts and expertise across multiple NASA sites. In one, the use of Consultative Committee for Space Data Systems (CCSDS) standards for the message abstraction layer provides an interoperability layer on top of existing ground data system communication architectures. This allows missions to select the most appropriate solutions for their requirements with a minimal investment in rehosting the components in a coherent operational environment. The other emphasizes shared tools and increased remote access to minimize travel for tests and critical activities and reduce the floor space required for a dedicated operations center. This paper summarizes these and other inter-center collaboration activities at the HOSC and the

  19. UCSF Center for HIV Information

    Science.gov (United States)

    ... Program For providers and patients VA National Viral Hepatitis Program For providers and patients TARGET Center Technical assistance tools for the Ryan White Community AETC National Resource Center Education and training for clinicians UCSF-Gladstone Center for ...

  20. Northeast Regional Planetary Data Center

    Science.gov (United States)

    Schultz, Peter H.; Saunders, Stephen (Technical Monitor)

    2005-01-01

    In 1980, the Northeast Planetary Data Center (NEPDC) was established with Tim Mutch as its Director. The Center was originally located in the Sciences Library due to space limitations but moved to the Lincoln Field Building in 1983 where it could serve the Planetary Group and outside visitors more effectively. In 1984 Dr. Peter Schultz moved to Brown University and became its Director after serving in a similar capacity at the Lunar and Planetary Institute since 1976. Debbie Glavin has served as the Data Center Coordinator since 1982. Initially the NEPDC was build around Tim Mutch's research collection of Lunar Orbiter and Mariner 9 images with only partial sets of Apollo and Viking materials. Its collection was broadened and deepened as the Director (PHS) searched for materials to fill in gaps. Two important acquisitions included the transfer of a Viking collection from a previous PI in Tucson and the donation of surplused lunar materials (Apollo) from the USGS/Menlo Park prior to its building being torn down. Later additions included the pipeline of distributed materials such as the Viking photomosaic series and certain Magellan products. Not all materials sent to Brown, however, found their way to the Data Center, e.g., Voyager prints and negatives. In addition to the NEPDC, the planetary research collection is separately maintained in conjunction with past and ongoing mission activities. These materials (e.g., Viking, Magellan, Galileo, MGS mission products) are housed elsewhere and maintained independently from the NEPDC. They are unavailable to other researchers, educators, and general public. Consequently, the NEPDC represents the only generally accessible reference collection for use by researchers, students, faculty, educators, and general public in the Northeast corridor.

  1. International Water Center

    Science.gov (United States)

    The urban district of Nancy and the Town of Nancy, France, have taken the initiative of creating an International Center of Water (Centre International de l'Eau à Nancy—NAN.C.I.E.) in association with two universities, six engineering colleges, the Research Centers of Nancy, the Rhine-Meuse Basin Agency, and the Chamber of Commerce and Industry. The aim of this center is to promote research and technology transfer in the areas of water and sanitation. In 1985 it will initiate a research program drawing on the experience of 350 researchers and engineers of various disciplines who have already been assigned to research in these fields. The research themes, the majority of which will be multidisciplinary, concern aspects of hygiene and health, the engineering of industrial processes, water resources, and the environment and agriculture. A specialist training program offering five types of training aimed at university graduates, graduates of engineering colleges, or experts, will start in October 1984.

  2. Center for Botanical Interaction Studies

    Data.gov (United States)

    Federal Laboratory Consortium — Research Area: Dietary Supplements, Herbs, Antioxidants Program:Centers for Dietary Supplements Research: Botanicals Description:This center will look at safety and...

  3. When teacher-centered instructors are assigned to student-centered classrooms

    Science.gov (United States)

    Lasry, Nathaniel; Charles, Elizabeth; Whittaker, Chris

    2014-06-01

    Technology-rich student-centered classrooms such as SCALE-UP and TEAL are designed to actively engage students. We examine what happens when the design of the classroom (conventional or teacher-centered versus student-centered classroom spaces) is consistent or inconsistent with the teacher's epistemic beliefs about learning and teaching (traditional or teacher-centered versus student-centered pedagogies). We compare two types of pedagogical approaches and two types of classroom settings through a quasiexperimental 2×2 factorial design. We collected data from 214 students registered in eight sections of an introductory calculus-based mechanics course given at a Canadian publicly funded two-year college. All students were given the Force Concept Inventory at the beginning and at the end of the 15-week-long course. We then focused on six teachers assigned to teach in the student-centered classroom spaces. We used qualitative observations and the Approaches to Teaching Inventory (ATI), a self-reported questionnaire, to determine the teachers' epistemic beliefs (teacher-centered or student-centered) and how these beliefs affected their use of the space and their students' conceptual learning. We report four main findings. First, the student-centered classroom spaces are most effective when used with student-centered pedagogies. Second, student-centered classrooms are ineffective when used with teacher-centered pedagogies and may have negative effects for students with low prior knowledge. Third, we find a strong correlation between six instructors' self-reported epistemic beliefs of student centeredness and their classes' average normalized gain (r =0.91; p =0.012). Last, we find that some instructors are more willing to adopt student-centered teaching practices after using student-centered classroom spaces. These data suggest that student-centered classrooms are effective only when instructors' epistemic framework of teaching and learning is consistent with a student-centered

  4. User Centered Design

    DEFF Research Database (Denmark)

    Egbert, Maria; Matthews, Ben

    2012-01-01

    The interdisciplinary approach of User Centered Design is presented here with a focus on innovation in the design and use of hearing technologies as well as on the potential of innovation in interaction. This approach is geared towards developing new products, systems, technologies and practices...... based on an understanding of why so few persons with hearing loss use the highly advanced hearing technologies. In integrating Conversation Analysis (“CA”), audiology and User Centered Design, three disciplines which are collaborating together for the first time, we are addressing the following...

  5. QUAD FAMILY CENTERING.

    Energy Technology Data Exchange (ETDEWEB)

    PINAYEV, I.

    2005-11-01

    It is well known that beam position monitors (BPM) utilizing signals from pickup electrodes (PUE) provide good resolution and relative accuracy. The absolute accuracy (i.e. position of the orbit in the vacuum chamber) is not very good due to the various reasons. To overcome the limitation it was suggested to use magnetic centers of quadrupoles for the calibration of the BPM [1]. The proposed method provides accuracy better then 200 microns for centering of the beam position monitors using modulation of the whole quadrupole family.

  6. Lied Transplant Center

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    The Department of Energy has prepared an Environmental Assessment (DOE/EA-1143) evaluating the construction, equipping and operation of the proposed Lied Transplant Center at the University of Nebraska Medical Center in Omaha, Nebraska. Based on the analysis in the EA, the DOE has determined that the proposed action does not constitute a major federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act of 1969 (NEPA). Therefore, the preparation of an Environmental Statement in not required.

  7. Xichang Satellite Launch Center

    Institute of Scientific and Technical Information of China (English)

    LiuJie

    2004-01-01

    Xichang Satellite Launch Center(XSLC) is mainly for geosynchronous orbit launches. The main purpose of XSLC is to launch spacecraft, such as broadcasting,communications and meteorological satellites, into geo-stationary orbit.Most of the commercial satellite launches of Long March vehicles have been from Xichang Satellite Launch Center. With 20 years' development,XSLC can launch 5 kinds of launch vehicles and send satellites into geostationary orbit and polar orbit. In the future, moon exploration satellites will also be launched from XSLC.

  8. Operating and Managing a Backup Control Center

    Science.gov (United States)

    Marsh, Angela L.; Pirani, Joseph L.; Bornas, Nicholas

    2010-01-01

    Due to the criticality of continuous mission operations, some control centers must plan for alternate locations in the event an emergency shuts down the primary control center. Johnson Space Center (JSC) in Houston, Texas is the Mission Control Center (MCC) for the International Space Station (ISS). Due to Houston s proximity to the Gulf of Mexico, JSC is prone to threats from hurricanes which could cause flooding, wind damage, and electrical outages to the buildings supporting the MCC. Marshall Space Flight Center (MSFC) has the capability to be the Backup Control Center for the ISS if the situation is needed. While the MSFC Huntsville Operations Support Center (HOSC) does house the BCC, the prime customer and operator of the ISS is still the JSC flight operations team. To satisfy the customer and maintain continuous mission operations, the BCC has critical infrastructure that hosts ISS ground systems and flight operations equipment that mirrors the prime mission control facility. However, a complete duplicate of Mission Control Center in another remote location is very expensive to recreate. The HOSC has infrastructure and services that MCC utilized for its backup control center to reduce the costs of a somewhat redundant service. While labor talents are equivalent, experiences are not. Certain operations are maintained in a redundant mode, while others are simply maintained as single string with adequate sparing levels of equipment. Personnel at the BCC facility must be trained and certified to an adequate level on primary MCC systems. Negotiations with the customer were done to match requirements with existing capabilities, and to prioritize resources for appropriate level of service. Because some of these systems are shared, an activation of the backup control center will cause a suspension of scheduled HOSC activities that may share resources needed by the BCC. For example, the MCC is monitoring a hurricane in the Gulf of Mexico. As the threat to MCC

  9. Assessment of adherence to highly active antiretroviral therapy and associated factors among people living with HIV at Debrebrihan Referral Hospital and Health Center, Northeast Ethiopia: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Ketema AK

    2015-03-01

    Full Text Available Abush Kebede Ketema,1 Zewdu Shewangizaw Weret21Regional Monitoring and Evaluation Advisor, Management Sciences for Health, Addis Ababa, Ethiopia; 2College of Medicine and Health Sciences, Arbaminch University, Arbaminch, EthiopiaAbstract: Patient adherence to antiretroviral combination therapy is a critical component to successful treatment outcome. Nonadherence to antiretroviral therapy (ART is a major challenge to AIDS care, and the risks associated with it are extensive. The intention of this study was to determine prevalence and associated factors with adherence to highly active ART among people living with HIV/AIDS (PLWHA at the Debrebrihan Referral Hospital and Health Center, Northeast Ethiopia. A cross-sectional study design with systematic random sampling conducted by the use of a structured, pretested self-rating adherence questionnaire was used to conduct the study among 422 respondents from the Debrebrihan Referral Hospital and Health Center. A single population proportion formula at 95% CI with 5% of marginal error at 50% of prevalence of occurrence was used to determine sample size. Adherence was defined as not missing a single ART dose during the 30-day period prior to filling out the self-report. Adherence was measured by self-reports by the patients. These results were then used in binary logistic regression analysis. Covariates were analyzed by bivariate and multivariate logistic regression with SPSS statistical software. The total number of respondents in this study was 422; their median age was 35 years. Among the participants, 95.5% were taking their medication without missing a dose. Factors such as having emotional or practical support positively encouraged ART adherence (adjusted odds ratio 0.16 [95% CI 0.05–0.49]. However, users of traditional, complementary, and alternative medicine (TCAM (adjusted odds ratio 4.7 [95% CI 1.06–21.22] had nearly a five times higher risk for ART nonadherence (P<0.05 than those not using

  10. User-Centered Design through Learner-Centered Instruction

    Science.gov (United States)

    Altay, Burçak

    2014-01-01

    This article initially demonstrates the parallels between the learner-centered approach in education and the user-centered approach in design disciplines. Afterward, a course on human factors that applies learner-centered methods to teach user-centered design is introduced. The focus is on three tasks to identify the application of theoretical and…

  11. Economics of data center optics

    Science.gov (United States)

    Huff, Lisa

    2016-03-01

    Traffic to and from data centers is now reaching Zettabytes/year. Even the smallest of businesses now rely on data centers for revenue generation. And, the largest data centers today are orders of magnitude larger than the supercomputing centers of a few years ago. Until quite recently, for most data center managers, optical data centers were nice to dream about, but not really essential. Today, the all-optical data center - perhaps even an all-single mode fiber (SMF) data center is something that even managers of medium-sized data centers should be considering. Economical transceivers are the key to increased adoption of data center optics. An analysis of current and near future data center optics economics will be discussed in this paper.

  12. MEASURING FINANCIAL PERFORMANCE TYPES OF RESPONSIBILITY CENTERS

    Directory of Open Access Journals (Sweden)

    LOREDANA CIURLĂU

    2012-11-01

    Full Text Available The financial performance of a responsibility center is measured on the basis of specific indicators of the nature center. To obtain a relevant and consistent images relating to the performance of an entity is required to use a system of indicators. Performance indicators of the structure it needs to capture at the same time, at least the following aspects: the objectives of the entity, its strategy, efficacy and effectiveness of activities carried out, the entity's ability to adapt to the requirements of the market in which they operate. Financial indicators of performance are the most objective, because most businesses give important resources for the activities of audit and control.

  13. EERC Center for Biomass Utilization 2006

    Energy Technology Data Exchange (ETDEWEB)

    Zygarlicke, Christopher J. [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center; Hurley, John P. [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center; Aulich, Ted R. [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center; Folkedahl, Bruce C. [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center; Strege, Joshua R. [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center; Patel, Nikhil [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center; Shockey, Richard E. [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center

    2009-05-27

    The Center for Biomass Utilization® 2006 project at the Energy & Environmental Research Center (EERC) consisted of three tasks related to applied fundamental research focused on converting biomass feedstocks to energy, liquid transportation fuels, and chemicals. Task 1, entitled Thermochemical Conversion of Biomass to Syngas and Chemical Feedstocks, involved three activities. Task 2, entitled Crop Oil Biorefinery Process Development, involved four activities. Task 3, entitled Management, Education, and Outreach, focused on overall project management and providing educational outreach related to biomass technologies through workshops and conferences.

  14. Graduate Automotive Technology Education (GATE) Center

    Energy Technology Data Exchange (ETDEWEB)

    Jeffrey Hodgson; David Irick

    2005-09-30

    The Graduate Automotive Technology Education (GATE) Center at the University of Tennessee, Knoxville has completed its sixth year of operation. During this period the Center has involved thirteen GATE Fellows and ten GATE Research Assistants in preparing them to contribute to advanced automotive technologies in the center's focus area: hybrid drive trains and control systems. Eighteen GATE students have graduated, and three have completed their course work requirements. Nine faculty members from three departments in the College of Engineering have been involved in the GATE Center. In addition to the impact that the Center has had on the students and faculty involved, the presence of the center has led to the acquisition of resources that probably would not have been obtained if the GATE Center had not existed. Significant industry interaction such as internships, equipment donations, and support for GATE students has been realized. The value of the total resources brought to the university (including related research contracts) exceeds $4,000,000. Problem areas are discussed in the hope that future activities may benefit from the operation of the current program.

  15. Center for beam physics 1996-1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-02-01

    The Center for Beam Physics (CBP) is a multidisciplinary research and development unit in the Accelerator and Fusion Research Division at the Ernest Orlando Lawrence Berkeley National Laboratory of the University of California. At the heart of the Center`s mission is the fundamental quest for mechanisms of acceleration, radiation, transport, and focusing of energy and information. Special features of the Center`s program include addressing R&D issues needing long development time and providing a platform for conception, initiation, and support of institutional projects based on beams. The Center brings to bear a significant amount of diverse, complementary, and self-sufficient expertise in accelerator physics, synchrotron radiation, advanced microwave techniques, plasma physics, optics, and lasers on the forefront R&D issues in particle and photon beam research. In addition to functioning as a clearinghouse for novel ideas and concepts and related R&D (e.g., various theoretical and experimental studies in beam physics such as nonlinear dynamics, phase space control, laser-beam-plasma interaction, free-electron lasers, optics, and instrumentation), the Center provides significant support to Laboratory facilities and initiatives. This roster and annual report provides a glimpse of the scientists, engineers, technical support, students, and administrative staff that make up the CBP`s outstanding team and gives a flavor of their multifaceted activities during 1996 and 1997.

  16. Starting a sleep center.

    Science.gov (United States)

    Epstein, Lawrence J; Valentine, Paul S

    2010-05-01

    The demand for sleep medicine services has grown tremendously during the last decade and will likely continue. To date, growth in demand has been met by growth in the number of new sleep centers. The need for more new centers will be dependent on market drivers that include increasing regulatory requirements, personnel shortages, integration of home sleep testing, changes in reimbursement, a shift in emphasis from diagnostics to treatment, and an increased consumer focus on sleep. The decision to open a new center should be based on understanding the market dynamics, completing a market analysis, and developing a business plan. The business plan should include an overview of the facility, a personnel and organizational structure, an evaluation of the business environment, a financial plan, a description of services provided, and a strategy for obtaining, managing, and extending a referral base. Implementation of the business plan and successful operation require ongoing planning and monitoring of operational parameters. The need for new sleep centers will likely continue, but the shifting market dynamics indicate a greater need for understanding the marketplace and careful planning. PMID:20442123

  17. INTERMOUNTAIN INDUSTRIAL ASSESSMENT CENTER

    Energy Technology Data Exchange (ETDEWEB)

    MELINDA KRAHENBUHL

    2010-05-28

    The U. S. Department of Energy’s Intermountain Industrial Assessment Center (IIAC) at the University of Utah has been providing eligible small- and medium-sized manufacturers with no-cost plant assessments since 2001, offering cost-effective recommendations for improvements in the areas of energy efficiency, pollution prevention, and productivity improvement.

  18. The Rural Information Center.

    Science.gov (United States)

    John, Patricia La Caille

    1989-01-01

    Describes the events that led to the creation of the Rural Information Center (RIC), a joint venture between the Extension Service and the National Agricultural Library to provide information to government officials involved in rural development. The databases accessed by RIC are described, and plans for a gateway system and network of all…

  19. Carolinas Energy Career Center

    Energy Technology Data Exchange (ETDEWEB)

    Classens, Anver; Hooper, Dick; Johnson, Bruce

    2013-03-31

    Central Piedmont Community College (CPCC), located in Charlotte, North Carolina, established the Carolinas Energy Career Center (Center) - a comprehensive training entity to meet the dynamic needs of the Charlotte region's energy workforce. The Center provides training for high-demand careers in both conventional energy (fossil) and renewable energy (nuclear and solar technologies/energy efficiency). CPCC completed four tasks that will position the Center as a leading resource for energy career training in the Southeast: • Development and Pilot of a New Advanced Welding Curriculum, • Program Enhancement of Non-Destructive Examination (NDE) Technology, • Student Support through implementation of a model targeted toward Energy and STEM Careers to support student learning, • Project Management and Reporting. As a result of DOE funding support, CPCC achieved the following outcomes: • Increased capacity to serve and train students in emerging energy industry careers; • Developed new courses and curricula to support emerging energy industry careers; • Established new training/laboratory resources; • Generated a pool of highly qualified, technically skilled workers to support the growing energy industry sector.

  20. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Flickr SlideShare All Pages & Documents Recalls & News Releases Home Recalls CPSC Recall API Recall Lawsuits Recalls by ... CO Poster Contest Toy Recall Statistics Pool Safely Home / Safety Education / Safety Education Centers En Español Carbon ...

  1. DISABILITY STATISTICS CENTER

    Science.gov (United States)

    The purpose of the Disability Statistics Center is to produce and disseminate statistical information on disability and the status of people with disabilities in American society and to establish and monitor indicators of how conditions are changing over time to meet their health...

  2. Memorial Alexander Center

    Directory of Open Access Journals (Sweden)

    AECK Associates, Arquitectos

    1958-05-01

    Full Text Available En Atlanta, el Instituto Tecnológico de Georgia acaba de ampliar sus instalaciones deportivas, construyendo el Alexander Memorial Center. Consta este nuevo Centro de dos edificios: una pista de baloncesto cubierta y un edificio anejo con vestuarios, duchas, una pista de entrenamiento, equipos técnicos y la emisora de radio Georgia Tech W. G. S. T.

  3. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... an Unsafe Product Consumers Businesses Contact CPSC Website Design Feedback Consumers: Español Businesses: Español , 中文 , Tiếng Việt ... Chairman Commissioners Contact Information Agency Reports Legislative Affairs Job Opportunities Inspector General Safety Guides Safety Education Centers ...

  4. Precision Joining Center

    Energy Technology Data Exchange (ETDEWEB)

    Powell, J.W.; Westphal, D.A.

    1991-08-01

    A workshop to obtain input from industry on the establishment of the Precision Joining Center (PJC) was held on July 10--12, 1991. The PJC is a center for training Joining Technologists in advanced joining techniques and concepts in order to promote the competitiveness of US industry. The center will be established as part of the DOE Defense Programs Technology Commercialization Initiative, and operated by EG G Rocky Flats in cooperation with the American Welding Society and the Colorado School of Mines Center for Welding and Joining Research. The overall objectives of the workshop were to validate the need for a Joining Technologists to fill the gap between the welding operator and the welding engineer, and to assure that the PJC will train individuals to satisfy that need. The consensus of the workshop participants was that the Joining Technologist is a necessary position in industry, and is currently used, with some variation, by many companies. It was agreed that the PJC core curriculum, as presented, would produce a Joining Technologist of value to industries that use precision joining techniques. The advantage of the PJC would be to train the Joining Technologist much more quickly and more completely. The proposed emphasis of the PJC curriculum on equipment intensive and hands-on training was judged to be essential.

  5. vCenter troubleshooting

    CERN Document Server

    Mills, Chuck

    2015-01-01

    The book is designed for the competent vCenter administrator or anyone who is responsible for the vSphere environment. It can be used as a guide by vSphere architects and VMware consultants for a successful vSphere solution. You should have good knowledge and an understanding of core elements and applications of the vSphere environment.

  6. Antifungal prophylaxis in stem cell transplantation centers in Turkey

    Directory of Open Access Journals (Sweden)

    Hamdi Akan

    2011-12-01

    Full Text Available Objective: This study aimed to determine the current state of antifungal prophylaxis in Turkish stem cell transplantation (SCT centers. Materials and Methods: The were 38 active stem cell transplantation centers in Turkey, 28 of which were registered with the European Group for Blood and Marrow Transplantation (EBMT. Survey questionnaires were sent to the 28 EBMT centers in an effort to collect data on antifungal prophylaxis in different settings. In all, 24 of the centers completed the survey; 1 of the 24 centers was excluded from the study, as it was under construction at the time and was not performing transplantation.Results: In all, 15 (65% of the 23 centers were adult SCT centers, 7 (31% were pediatric SCT centers, and 1 center treated both adult and pediatric patients. All centers (23/23 performed both allogeneic and autologous transplants, 20 centers performed non-myeloablative transplants, 8 performed cord blood transplants, and 7 performed unrelated transplants. Primary antifungal prophylaxis was used at all 23 centers during allogeneic transplants, whereas 18 of the 23 centers used it during every autologous transplant and 2 of the 23 centers used it during autologous transplants on a per case basis. The most common drug used for prophylaxis was fluconazole (F (21/23, followed by itraconazole (I (3/23, amphotericin-B (2/23, and posaconazole (1/23. Among the 23 centers, 3 reported that for allogenic transplants they changed the antifungal prophylactic in cases of graft versus host disease (GVHD, and 12 of the 23 centers reported that they changed the antifungal prophylactic in case of nearby construction. All 23 centers performed secondary prophylaxis. Conclusion: Antifungal prophylaxis for hematopoetic SCT patients was the standard protocol in the 23 centers included in the study, usually with such azoles as F. The introduction of posaconazole in Turkey and the potential approval of voriconazole for antifungal prophylaxis will

  7. American Overseas Research Centers Program

    Science.gov (United States)

    Office of Postsecondary Education, US Department of Education, 2012

    2012-01-01

    The American Overseas Research Centers Program provides grants to overseas research centers that are consortia of U.S. institutions of higher education to enable the centers to promote postgraduate research, exchanges, and area studies. Eligible applicants are those consortia of U.S. institutions of higher education centers that: (1) Receive more…

  8. Radiological protection and calibration of an activity meter with cesium and barium sources in a nuclear medicine center; Proteccion radiologica y calibracion de un activimetro con fuentes de cesio y bario en un centro de medicina nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Morales L, M.E. [IPEN INEN Centro de Medicina Nuclear, Av. Aviacion 3799, Lima 34 (Peru)

    2005-07-01

    Presently work is shown the results when gauging a team Deluxe Isotope (Caliper 11) with some sources of Cesium 137 and Barium 133, in a Center of Medicine Nuclear that operates from the anus 1983 in a modern building inside the one Institute of Illnesses Neoplasia (Inn). This Center was equipped initially with teams donated by the International Organism of Atomic Energy (Oa) with those that it develops assistance, educational works and of investigation, giving services to patient of the Inn and other public and private medical centers. (Author)

  9. Strategic Project Management at the NASA Kennedy Space Center

    Science.gov (United States)

    Lavelle, Jerome P.

    2000-01-01

    This paper describes Project Management at NASA's Kennedy Space Center (KSC) from a strategic perspective. It develops the historical context of the agency and center's strategic planning process and illustrates how now is the time for KSC to become a center which has excellence in project management. The author describes project management activities at the center and details observations on those efforts. Finally the author describes the Strategic Project Management Process Model as a conceptual model which could assist KSC in defining an appropriate project management process system at the center.

  10. Application Center 2000

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@ 在NET Enterprise Servers中,Application Center 2000扮演着企业管理电子商务分布式应用程序的重要角色.ApplicationCenter 2000是可以建立在Windows 2000上的网站应用程序,能够有效率地管理、降低企业成本.它也是一个向外拓展的技术,且通过丛集服务(Cluster Service),可随需求增加其扩展性与可用性,以此降低随之而来的高成本和管理方式,以及提供配置(Deploy)丛集服务器的能力.

  11. Entanglement with Centers

    CERN Document Server

    Ma, Chen-Te

    2015-01-01

    Entanglement is a physical phenomenon that each state cannot be described individually. Entanglement entropy gives quantitative understanding to the entanglement. We use decomposition of the Hilbert space to discuss properties of the entanglement. Therefore, partial trace operator becomes important to define the reduced density matrix from different centers, which commutes with all elements in the Hilbert space, corresponding to different entanglement choices or different observations on entangling surface. Entanglement entropy is expected to satisfy the strong subadditivity. We discuss decomposition of the Hilbert space for the strong subadditivity and other related inequalities. The entanglement entropy with centers can be computed from the Hamitonian formulations systematically, provided that we know wavefunctional. In the Hamitonian formulation, it is easier to obtain symmetry structure. We consider massless $p$-form theory as an example. The massless $p$-form theory in ($2p+2)$-dimensions has global symm...

  12. 4 Exhibition Centers

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    China's convention and exhibition industry has grown rapidly in recent years, with some of the nation's key cities becoming hubs of internationally renowned expositions, spurred by the construction of new exhibition centers.In 2003, a total of 3,298 conventions and exhibitions were held in China, up from 3,075 in the previous year. The number is estimated to have hit 4,000 in 2004.

  13. COMPUTATIONAL SCIENCE CENTER

    Energy Technology Data Exchange (ETDEWEB)

    DAVENPORT,J.

    2004-11-01

    The Brookhaven Computational Science Center brings together researchers in biology, chemistry, physics, and medicine with applied mathematicians and computer scientists to exploit the remarkable opportunities for scientific discovery which have been enabled by modern computers. These opportunities are especially great in computational biology and nanoscience, but extend throughout science and technology and include for example, nuclear and high energy physics, astrophysics, materials and chemical science, sustainable energy, environment, and homeland security.

  14. Advantage from Funding Durable Centers Leasing

    Directory of Open Access Journals (Sweden)

    Alina Zając

    2009-09-01

    Full Text Available In present market conditions huge number of businessmen has problems from gain over from banks capital on purchase of durable centers not only, but also on develop - ment and operating activity Individual can use with different forms funding investment, it which is between different leasing.

  15. Schiffert Health Center issues campus flu update

    OpenAIRE

    Owczarski, Mark

    2010-01-01

    Cases of seasonal flu virus infection on campus have diminished, and so far the flu season has been less active than health authorities expected. Schiffert Health Center reports a much lower number of students seeking treatment for seasonal flu infections compared to the fall semester.

  16. [Communication center in public health].

    Science.gov (United States)

    George, W; Grimminger, F; Krause, B

    2002-06-01

    The Communications Center's portfolio covers areas such as marketing, contacts, distribution of information, sales activities and collection of bills by telephone (encashment). A special emphasis is Customer Care Management (Customer Relationship Management) to the patient and his caregivers (relatives), the customers, especially the physicians who send their patients to the hospital and the hospital doctor. By providing communication centers, the hospital would be able to improve the communication with the G.P.s, and identify the wishes and requirements more accurately and easily from the beginning. Dealing effectively with information and communication is already also of special importance for hospital doctors today. One can assume that the demands on doctors in this respect will become even more complex in the future. Doctors who are involved in scientific research are of course fully aware of the growing importance of the Internet with its new information and communication channels. Therefore analysing the current situation, the demands on a future information management system can be formulated: A system that will help doctors to avoid dealing with little goal-oriented information and thus setting up effective communication channels; an information system which is multi-media oriented towards the interests and needs of the patients and patient's relatives and which is further developed continually and directly by those involved. PMID:12094467

  17. Reinventing the academic health center.

    Science.gov (United States)

    Kirch, Darrell G; Grigsby, R Kevin; Zolko, Wayne W; Moskowitz, Jay; Hefner, David S; Souba, Wiley W; Carubia, Josephine M; Baron, Steven D

    2005-11-01

    Academic health centers have faced well-documented internal and external challenges over the last decade, putting pressure on organizational leaders to develop new strategies to improve performance while simultaneously addressing employee morale, patient satisfaction, educational outcomes, and research growth. In the aftermath of a failed merger, new leaders of The Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center encountered a climate of readiness for a transformational change. In a case study of this process, nine critical success factors are described that contributed to significant performance improvement: performing a campus-wide cultural assessment and acting decisively on the results; making values explicit and active in everyday decisions; aligning corporate structure and governance to unify the academic enterprise and health system; aligning the next tier of administrative structure and function; fostering collaboration and accountability-the creation of unified campus teams; articulating a succinct, highly focused, and compelling vision and strategic plan; using the tools of mission-based management to realign resources; focusing leadership recruitment on organizational fit; and "growing your own" through broad-based leadership development. Outcomes assessment data for academic, research, and clinical performance showed significant gains between 2000 and 2004. Organizational transformation as a result of the nine factors is possible in other institutional settings and can facilitate a focus on crucial quality initiatives. PMID:16249294

  18. Reinventing the academic health center.

    Science.gov (United States)

    Kirch, Darrell G; Grigsby, R Kevin; Zolko, Wayne W; Moskowitz, Jay; Hefner, David S; Souba, Wiley W; Carubia, Josephine M; Baron, Steven D

    2005-11-01

    Academic health centers have faced well-documented internal and external challenges over the last decade, putting pressure on organizational leaders to develop new strategies to improve performance while simultaneously addressing employee morale, patient satisfaction, educational outcomes, and research growth. In the aftermath of a failed merger, new leaders of The Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center encountered a climate of readiness for a transformational change. In a case study of this process, nine critical success factors are described that contributed to significant performance improvement: performing a campus-wide cultural assessment and acting decisively on the results; making values explicit and active in everyday decisions; aligning corporate structure and governance to unify the academic enterprise and health system; aligning the next tier of administrative structure and function; fostering collaboration and accountability-the creation of unified campus teams; articulating a succinct, highly focused, and compelling vision and strategic plan; using the tools of mission-based management to realign resources; focusing leadership recruitment on organizational fit; and "growing your own" through broad-based leadership development. Outcomes assessment data for academic, research, and clinical performance showed significant gains between 2000 and 2004. Organizational transformation as a result of the nine factors is possible in other institutional settings and can facilitate a focus on crucial quality initiatives.

  19. 固体催化剂活性中心的分子设计及其XAFS表征%Molecular Design and XAFS Characterization of Active Centers of Solid-State Catalysts

    Institute of Scientific and Technical Information of China (English)

    龙金林; 顾泉; 张子重; 王绪绪

    2011-01-01

    Surface organometallic chemistry(SOMC) is an effective route to design and prepare surface metal species with well-defined composition and molecular structure.Synchrotron radiation X-ray absorption fine structure spectroscopy(XAFS) technique is currently a powerful tool to characterize geometrical structure of active sites of solid-state catalysts.Their combination provided a method to design and construct in molecular level catalytic active centres,which was established to be one of the important goals in the field of heterogeneous catalysis.This article reviews the recent advancements in construction of single-site active metallic centre in the channels and cages of zeolite molecular sieves by the SOMC method and in characterizing geometrical structure of active sites of heterogeneous catalytic materials with XAFS,the physical fundament,experimental methods,and data analysis of XAFS technique and its merits and demerits in characterization of catalytic materials,the chemical fundament of SOMC.Single-site mononuclear or polynuclear Ti,Cu,and Fe active centers were successfully constructed in molecular level in the channels and cages of zeolite molecular sieves by the SOMC method.Their micro-structures were characterized in detail with XAFS combined other spectroscopic techniques and their catalytic properties were evaluated.The catalytic nature of these metallic centers was elucidated by establishing the inherent relationship among structure,activity,and composition.The study results revealed in molecular level the pyrolysis mechanism of Cu2 over the MCM-41 surface,and showed a novel route to prepare CuO,Cu2O and Cu(0)/MCM-41 materials with well-defined composition and micro-structure,clarifying the hydroxylation mechanism of phenol over copper active sites and the nuclearity-dependent catalytic function of iron-oxo species;based on the binuclear diiron [FeIII-(μ-O)(μ-OH)-FeⅢ] clusters with well-defined structure and composition constructed

  20. The MAGIC Data Center

    OpenAIRE

    Reichardt, Ignasi; Rico, Javier; Carmona, Emiliano; Contreras, Jose Luis; Cortina, Juan; Firpo, Roger; Font, Lluis; Moralejo, Abelardo; Nieto, Daniel; Oya, Igor; Reyes, Raquel de los

    2009-01-01

    The MAGIC I telescope produces currently around 100TByte of raw data per year that is calibrated and reduced on-site at the Observatorio del Roque de los Muchachos (La Palma). Since February 2007 most of the data have been stored and further processed in the Port d'Informacio Cientifica (PIC), Barcelona. This facility, which supports the GRID Tier 1 center for LHC in Spain, provides resources to give the entire MAGIC Collaboration access to the reduced telescope data. It is expected that the ...

  1. COMPUTATIONAL SCIENCE CENTER

    Energy Technology Data Exchange (ETDEWEB)

    DAVENPORT, J.

    2005-11-01

    The Brookhaven Computational Science Center brings together researchers in biology, chemistry, physics, and medicine with applied mathematicians and computer scientists to exploit the remarkable opportunities for scientific discovery which have been enabled by modern computers. These opportunities are especially great in computational biology and nanoscience, but extend throughout science and technology and include, for example, nuclear and high energy physics, astrophysics, materials and chemical science, sustainable energy, environment, and homeland security. To achieve our goals we have established a close alliance with applied mathematicians and computer scientists at Stony Brook and Columbia Universities.

  2. Center of excellence in laser medicine. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Parrish, J.A.

    1992-09-01

    Achievements during the first six months of funding to prepare for a Center of Excellence in biomedical laser development include limited specific research projects within the Center`s three broad interest areas, and program development to establish the Center and its activities. Progress in the three interest areas -- new medical laser systems development, optical diagnostics, and photosensitization, is reported. Feasibility studies and prototype development were emphasized, to enhance establishing a substantial Center through future support. Specific projects are an optimized laser-catheter system for reversal of vasospasm; optical detection of major skin burn depth and cancers using fluorescent drugs, and photosensitization of vascular tissues. In addition, an interdepartmental Laser Center was established at MGH to enhance collaborations and institutional committment to the Center of Excellence. Competitive postdoctoral research fellowships, with provision for matching funds from other departments, have been announced.

  3. National Center for Biotechnology Information

    Science.gov (United States)

    ... to NCBI Sign Out NCBI National Center for Biotechnology Information Search database All Databases Assembly BioProject BioSample ... Search Welcome to NCBI The National Center for Biotechnology Information advances science and health by providing access ...

  4. Contact Center Manager Administration (CCMA)

    Data.gov (United States)

    Social Security Administration — CCMA is the server that provides a browser-based tool for contact center administrators and supervisors. It is used to manage and configure contact center resources...

  5. Oceans and Human Health Center

    Science.gov (United States)

    ... through a deeper understanding of the causes of ocean-related health threats About Find out more about our Center ... research taking place at the University of Miami Oceans & Human Health Center More Gallery Check out our photo and ...

  6. Dialysis centers - what to expect

    Science.gov (United States)

    ... what to expect; Renal replacement therapy - dialysis centers; End-stage renal disease - dialysis centers; Kidney failure - dialysis ... swells and the hand on that side feels cold Your hand gets cold, numb, or weak Also ...

  7. The MAGIC Data Center

    CERN Document Server

    Reichardt, Ignasi; Carmona, Emiliano; Contreras, Jose Luis; Cortina, Juan; Firpo, Roger; Font, Lluis; Moralejo, Abelardo; Nieto, Daniel; Oya, Igor; Reyes, Raquel de los

    2009-01-01

    The MAGIC I telescope produces currently around 100TByte of raw data per year that is calibrated and reduced on-site at the Observatorio del Roque de los Muchachos (La Palma). Since February 2007 most of the data have been stored and further processed in the Port d'Informacio Cientifica (PIC), Barcelona. This facility, which supports the GRID Tier 1 center for LHC in Spain, provides resources to give the entire MAGIC Collaboration access to the reduced telescope data. It is expected that the data volume will increase by a factor 3 after the start-up of the second telescope, MAGIC II. The project to improve the MAGIC Data Center to meet these requirements is presented. In addition, we discuss the production of high level data products that will allow a more flexible analysis and will contribute to the international network of astronomical data (European Virtual Observatory). For this purpose, we will have to develop a new software able to adapt the analysis process to different data taking conditions, such as ...

  8. Core Research Center

    Science.gov (United States)

    Hicks, Joshua; Adrian, Betty

    2009-01-01

    The Core Research Center (CRC) of the U.S. Geological Survey (USGS), located at the Denver Federal Center in Lakewood, Colo., currently houses rock core from more than 8,500 boreholes representing about 1.7 million feet of rock core from 35 States and cuttings from 54,000 boreholes representing 238 million feet of drilling in 28 States. Although most of the boreholes are located in the Rocky Mountain region, the geologic and geographic diversity of samples have helped the CRC become one of the largest and most heavily used public core repositories in the United States. Many of the boreholes represented in the collection were drilled for energy and mineral exploration, and many of the cores and cuttings were donated to the CRC by private companies in these industries. Some cores and cuttings were collected by the USGS along with other government agencies. Approximately one-half of the cores are slabbed and photographed. More than 18,000 thin sections and a large volume of analytical data from the cores and cuttings are also accessible. A growing collection of digital images of the cores are also becoming available on the CRC Web site Internet http://geology.cr.usgs.gov/crc/.

  9. The Backgrounds Data Center

    Science.gov (United States)

    Snyder, W. A.; Gursky, H.; Heckathorn, H. M.; Lucke, R. L.; Berg, S. L.; Dombrowski, E. G.; Kessel, R. A.

    1993-01-01

    The Strategic Defense Initiative Organization has created data centers for midcourse, plumes, and backgrounds phenomenologies. The Backgrounds Data Center (BDC) has been designated as the prime archive for data collected by SDIO programs. The BDC maintains a Summary Catalog that contains 'metadata,' that is, information about data, such as when the data were obtained, what the spectral range of the data is, and what region of the Earth or sky was observed. Queries to this catalog result in a listing of all data sets (from all experiments in the Summary Catalog) that satisfy the specified criteria. Thus, the user can identify different experiments that made similar observations and order them from the BDC for analysis. On-site users can use the Science Analysis Facility (SAFE for this purpose. For some programs, the BDC maintains a Program Catalog, which can classify data in as many ways as desired (rather than just by position, time, and spectral range as in the Summary Catalog). For example, data sets could be tagged with such diverse parameters as solar illumination angle, signal level, or the value of a particular spectral ratio, as long as these quantities can be read from the digital record or calculated from it by the ingest program. All unclassified catalogs and unclassified data will be remotely accessible.

  10. Operative center of the geophysical prognosis in Izmiran

    OpenAIRE

    Belov, A. V.; Gaidash, S. P.; K. D. Kanonidi; K. K. Kanonidi; Kuznetsov, V. D.; E. A. Eroshenko

    2005-01-01

    IZMIRAN was founded about 65 years ago with one of the goals of carrying out geomagnetic prognoses. More or less, this activity has been developed during its entire history, but about 6 years ago this aim became sufficiently feasible due to the organization of the Forecasting Center of helio-geo-physical conditions. This Center appeared in response to new technologies, numerous new data available and new social demand. The Center uses the extended experimental basis of IZMIRAN and all availab...

  11. On chains of centered valuations

    Directory of Open Access Journals (Sweden)

    Rachid Chibloun

    2003-01-01

    Full Text Available We study chains of centered valuations of a domain A and chains of centered valuations of A [X1,…,Xn] corresponding to valuations of A. Finally, we make some applications to chains of valuations centered on the same ideal of A [X1,…,Xn] and extending the same valuation of A.

  12. CURRICULUM GUIDE, CHILD CARE CENTERS.

    Science.gov (United States)

    California State Dept. of Education, Sacramento.

    CALIFORNIA CHILD CARE CENTERS WERE ESTABLISHED IN 1943 TO SUPPLY SERVICES TO CHILDREN OF WORKING MOTHERS. THE CHILD CARE PROGRAM PROVIDES, WITHIN NURSERY AND SCHOOLAGE CENTERS, CARE AND EDUCATIONAL SUPERVISION FOR PRESCHOOL AND ELEMENTARY SCHOOL AGE CHILDREN. THE PHILOSOPHY OF THE CHILD CENTER PROGRAM IS BASED UPON THE BELIEF THAT EACH CHILD…

  13. The double luminescence of Color Centers

    International Nuclear Information System (INIS)

    An experiment on the luminescence of Color Centers (CCs) carried out in 1987 at the ENEA Laboratories in Frascati had a negative result, but subsequent investigations showed that it was not a failure but rather a discovery of a new phenomenon. Since the coming of lasers, CCs in alkali halides have been successfully used as optically active materials, in particular FA Centers. One of these centers, well known for its medium infrared laser emission at 77 K, cooled further to 2 K emitted in the near infrared and without laser effect. Further investigations showed that the double luminescence was a fundamental property unknown until that time. This important discovery was achieved in Frascati because of the existence since 1973 of a solid and extensive expertise in the field of CCs, which continued over time and later on applied to the modern miniaturized photonic devices

  14. Center for Beam Physics: 1994--95

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-05-01

    The Center for Beam Physics is a multidisciplinary research and development unit in the Accelerator and Fusion Research Division at the Lawrence Berkeley Laboratory of the University of California. At the heart of the Center`s mission is a fundamental quest for mechanisms of acceleration, radiation, transport, and focusing of energy and information. Dedicated to exploring the frontiers of particle and photon beam physics, its primary mission is to promote the science and technology of the production, manipulation, storage, and control of systems of charged particles and photons. This roster and annual report provides a glimpse of the scientists, engineers, technical support, students, and administrative staff that make up the CBP`s team and gives a brief review of the multifaceted activities during 1994 and 1995.

  15. The Activity of Archive to Preserve the Memory of the Events and Participants of the Great Patriotic War: the Experience of the Documentation Center of the Modern History of the Rostov Region

    Directory of Open Access Journals (Sweden)

    Olga V. Valuyskova

    2015-07-01

    Full Text Available The article characterizes the forms of use of archival documents about World War II in order to popularize scientific knowledge and patriotic education. This article was prepared on the basis of experience of the Documentation Center of the Modern History of the Rostov Region.

  16. Citizen centered design

    Directory of Open Access Journals (Sweden)

    Ingrid Mulder

    2015-11-01

    Full Text Available Today architecture has to design for rapidly changing futures, in a citizen-centered way. That is, architecture needs to embrace meaningful design. Societal challenges ask for a new paradigm in city-making, which combines top-down public management with bottom-up social innovation to reach meaningful design. The biggest challenge is indeed to embrace a new collaborative attitude, a participatory approach, and to have the proper infrastructure that supports this social fabric. Participatory design and transition management are future-oriented, address people and institutions. Only through understanding people in context and the corresponding dynamics, one is able to design for liveable and sustainable urban environments, embracing the human scale.

  17. Interactive design center.

    Energy Technology Data Exchange (ETDEWEB)

    Pomplun, Alan R. (Sandia National Laboratories, Livermore, CA)

    2005-07-01

    Sandia's advanced computing resources provide researchers, engineers and analysts with the ability to develop and render highly detailed large-scale models and simulations. To take full advantage of these multi-million data point visualizations, display systems with comparable pixel counts are needed. The Interactive Design Center (IDC) is a second generation visualization theater designed to meet this need. The main display integrates twenty-seven projectors in a 9-wide by 3-high array with a total display resolution of more than 35 million pixels. Six individual SmartBoard displays offer interactive capabilities that include on-screen annotation and touch panel control of the facility's display systems. This report details the design, implementation and operation of this innovative facility.

  18. Mi Pueblo Food Center

    Directory of Open Access Journals (Sweden)

    Alexis A. Babb

    2016-04-01

    Full Text Available This case describes a current growth opportunity for Mi Pueblo Food Center, a Hispanic grocery chain with locations throughout the Bay Area, California. The CEO of Mi Pueblo is contemplating opening a new store location in East Palo Alto, CA, which has been without a local, full-service grocery store for over 20 years. Case objectives are for students to develop an understanding of how the grocery industry operates, the risks and opportunities associated with opening a new grocery store location, and the impact on social, environmental, and economic sustainability. The SWOT (Strengths, Weaknesses, Opportunities, Threats framework is used to analyze whether or not it is feasible for Mi Pueblo to open a new location in East Palo Alto. This case may be used with students in graduate and advanced undergraduate courses.

  19. Industrial Assessment Center Program

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Dereje Agonafer

    2007-11-30

    The work described in this report was performed under the direction of the Industrial Assessment Center (IAC) at University of Texas at Arlington. The IAC at The University of Texas at Arlington is managed by Rutgers University under agreement with the United States Department of Energy Office of Industrial Technology, which financially supports the program. The objective of the IAC is to identify, evaluate, and recommend, through analysis of an industrial plant’s operations, opportunities to conserve energy and prevent pollution, thereby reducing the associated costs. IAC team members visit and survey the plant. Based upon observations made in the plant, preventive/corrective actions are recommended. At all times we try to offer specific and quantitative recommendations of cost savings, energy conservation, and pollution prevention to the plants we serve.

  20. Supernova Science Center

    Energy Technology Data Exchange (ETDEWEB)

    S. E. Woosley

    2008-05-05

    The Supernova Science Center (SNSC) was founded in 2001 to carry out theoretical and computational research leading to a better understanding of supernovae and related transients. The SNSC, a four-institutional collaboration, included scientists from LANL, LLNL, the University of Arizona (UA), and the University of California at Santa Cruz (UCSC). Intitially, the SNSC was funded for three years of operation, but in 2004 an opportunity was provided to submit a renewal proposal for two years. That proposal was funded and subsequently, at UCSC, a one year no-cost extension was granted. The total operational time of the SNSC was thus July 15, 2001 - July 15, 2007. This document summarizes the research and findings of the SNSC and provides a cummulative publication list.

  1. Data-analysis center

    International Nuclear Information System (INIS)

    Changes at the data analysis center are summarized. The most dramatic change in the operation of the Data-Analysis Center (DAC) has been the implementation of a VAX cluster. The cluster is a network of loosely coupled VAX computers tied together with a high-speed network and sharing common disks. System software was enhanced with the addition of DECalc, a spread-sheet program for the VAX. EUNICE, a UNIX environment package that is layered on VMS, was added to VAX machine MPFG0. Networking capabilities in the DAC were significantly increased during 1984. Specifically, access to remote networks, such as TELENET, was made easier through the C-Division computers. In addition, the DAC acquired dial-out modems and software so that users could transfer files between DAC machines and other computers over phone lines. A major project in the data-acquisition section in the past year was a special-purpose multiprocessor system to analyze data generated at LAMPF. During the year requirements for the system have been defined, hardware for a prototype system (PDP-11/730s and Ethernet) has been selected, and the system software has been designed. During 1984 both Q replay and data acquisition using VAXes and the VMS operating system were fully implemented and released to users. VAX data acquisition was used successfully in experiments at EPICS at LAMPF, at the Bates Linear Accelerator in Massachusetts, and at the Bevalac at Lawrence Berkeley National Laboratory. The EPICS VAX-11/730 system was upgraded to a VAX-11/750 at the end of 1984 to improve on-line response and performance. Another VAX-11/750 is being purchased for HRS

  2. Actions Needed to Ensure Scientific and Technical Information is Adequately Reviewed at Goddard Space Flight Center, Johnson Space Center, Langley Research Center, and Marshall Space Flight Center

    Science.gov (United States)

    2008-01-01

    This audit was initiated in response to a hotline complaint regarding the review, approval, and release of scientific and technical information (STI) at Johnson Space Center. The complainant alleged that Johnson personnel conducting export control reviews of STI were not fully qualified to conduct those reviews and that the reviews often did not occur until after the STI had been publicly released. NASA guidance requires that STI, defined as the results of basic and applied scientific, technical, and related engineering research and development, undergo certain reviews prior to being released outside of NASA or to audiences that include foreign nationals. The process includes technical, national security, export control, copyright, and trade secret (e.g., proprietary data) reviews. The review process was designed to preclude the inappropriate dissemination of sensitive information while ensuring that NASA complies with a requirement of the National Aeronautics and Space Act of 1958 (the Space Act)1 to provide for the widest practicable and appropriate dissemination of information resulting from NASA research activities. We focused our audit on evaluating the STI review process: specifically, determining whether the roles and responsibilities for the review, approval, and release of STI were adequately defined and documented in NASA and Center-level guidance and whether that guidance was effectively implemented at Goddard Space Flight Center, Johnson Space Center, Langley Research Center, and Marshall Space Flight Center. Johnson was included in the review because it was the source of the initial complaint, and Goddard, Langley, and Marshall were included because those Centers consistently produce significant amounts of STI.

  3. A Computer Learning Center for Environmental Sciences

    Science.gov (United States)

    Mustard, John F.

    2000-01-01

    In the fall of 1998, MacMillan Hall opened at Brown University to students. In MacMillan Hall was the new Computer Learning Center, since named the EarthLab which was outfitted with high-end workstations and peripherals primarily focused on the use of remotely sensed and other spatial data in the environmental sciences. The NASA grant we received as part of the "Centers of Excellence in Applications of Remote Sensing to Regional and Global Integrated Environmental Assessments" was the primary source of funds to outfit this learning and research center. Since opening, we have expanded the range of learning and research opportunities and integrated a cross-campus network of disciplines who have come together to learn and use spatial data of all kinds. The EarthLab also forms a core of undergraduate, graduate, and faculty research on environmental problems that draw upon the unique perspective of remotely sensed data. Over the last two years, the Earthlab has been a center for research on the environmental impact of water resource use in and regions, impact of the green revolution on forest cover in India, the design of forest preserves in Vietnam, and detailed assessments of the utility of thermal and hyperspectral data for water quality analysis. It has also been used extensively for local environmental activities, in particular studies on the impact of lead on the health of urban children in Rhode Island. Finally, the EarthLab has also served as a key educational and analysis center for activities related to the Brown University Affiliated Research Center that is devoted to transferring university research to the private sector.

  4. Program strategy document for the Nuclear Materials Transportation Technology Center

    International Nuclear Information System (INIS)

    A multiyear program plan is presented which describes the program of the Nuclear Materials Transportation Technology Center (TIC) at Sandia Laboratories. The work element plans, along with their corresponding work breakdown structures, are presented for TTC activities in the areas of Technology and Information Center, Systems Development, Technology, and Institutional Issues for the years from 1979 to 1985

  5. Center for beam physics 1996-1997

    International Nuclear Information System (INIS)

    The Center for Beam Physics (CBP) is a multidisciplinary research and development unit in the Accelerator and Fusion Research Division at the Ernest Orlando Lawrence Berkeley National Laboratory of the University of California. At the heart of the Center's mission is the fundamental quest for mechanisms of acceleration, radiation, transport, and focusing of energy and information. Special features of the Center's program include addressing R ampersand D issues needing long development time and providing a platform for conception, initiation, and support of institutional projects based on beams. The Center brings to bear a significant amount of diverse, complementary, and self-sufficient expertise in accelerator physics, synchrotron radiation, advanced microwave techniques, plasma physics, optics, and lasers on the forefront R ampersand D issues in particle and photon beam research. In addition to functioning as a clearinghouse for novel ideas and concepts and related R ampersand D (e.g., various theoretical and experimental studies in beam physics such as nonlinear dynamics, phase space control, laser-beam-plasma interaction, free-electron lasers, optics, and instrumentation), the Center provides significant support to Laboratory facilities and initiatives. This roster and annual report provides a glimpse of the scientists, engineers, technical support, students, and administrative staff that make up the CBP's outstanding team and gives a flavor of their multifaceted activities during 1996 and 1997

  6. Global Challenges in People-Centered E-Health.

    Science.gov (United States)

    Quintana, Yuri; Safran, Charles

    2015-01-01

    People-centered health care seeks an active role for the patient while empowering all other members of the health care team. By promoting greater patient responsibility and optimal usage, patient-centered health care leads to improved health outcomes, quality of life and optimal value for health care investment. This paper reviews some definitions of people-centered health care and various e-health approaches around the world used to implement this vision. The barriers and enablers to implementation this type of approach are explored. This paper provides a proposed research agenda for future implementations of people-centered e-health.

  7. University of Illinois at Chicago Health Policy Center - Funding

    Data.gov (United States)

    U.S. Department of Health & Human Services — 1991-2013. Centers for Disease Control and Prevention (CDC). State Tobacco Activities Tracking and Evaluation (STATE) System. Funding Data, Appropriations...

  8. ORAL PRESENTATION:EPA'S ENVIRONMENTAL PHOTOGRAPHIC INTERPRETATION CENTER (EPIC)

    Science.gov (United States)

    This presentation provides an overview of the remote sensing technical support and research and development activities of the Environmental Photographic Interprettion Center (EPIC). It is the basis for a presentation given at the EPA's Office of Acquisition Management's Annual C...

  9. Environmental Geographic Information Systems (EGIS) at Stennis Space Center (SSC)

    Science.gov (United States)

    Carr, Hugh; Smoot, James; Parikh, Joy

    2004-01-01

    This viewgraph presentation includes: 1) Background of SSC Environmental GIS (EGIS); 2) Principal Center Activities; 3) SSC's GIS Applications: a) Environmental Emergency Response Tool, b) CERCLA, c) Facilities Master Planning, d) Natural Resource Management and Site Assessment.

  10. University of Illinois at Chicago Health Policy Center - Funding

    Data.gov (United States)

    U.S. Department of Health & Human Services — 1991-2014. Centers for Disease Control and Prevention (CDC). State Tobacco Activities Tracking and Evaluation (STATE) System. Funding Data, Appropriations...

  11. Kennedy Space Center

    Science.gov (United States)

    Griffin, Amanda

    2012-01-01

    Among 2011's many accomplishments, we safely retired the Space Shuttle Program after 30 incredible years; completed the International Space Station and are taking steps to enable it to reach its full potential as a multi-purpose laboratory; and helped to expand scientific knowledge with missions like Aquarius, GRAIL, and the Mars Science Laboratory. Responding to national budget challenges, we are prioritizing critical capabilities and divesting ourselves of assets no longer needed for NASA's future exploration programs. Since these facilities do not have to be maintained or demolished, the government saves money. At the same time, our commercial partners save money because they do not have to build new facilities. It is a win-win for everyone. Moving forward, 2012 will be even more historically significant as we celebrate the 50th Anniversary of Kennedy Space Center. In the coming year, KSC will facilitate commercial transportation to low-Earth orbit and support the evolution of the Space Launch System and Orion crew vehicle as they ready for exploration missions, which will shape how human beings view the universe. While NASA's Vision is to lead scientific and technological advances in aeronautics and space for a Nation on the frontier of discovery KSC's vision is to be the world's preeminent launch complex for government and commercial space access, enabling the world to explore and work in space. KSC's Mission is to safely manage, develop, integrate, and sustain space systems through partnerships that enable innovative, diverse access to space and inspires the Nation's future explorers.

  12. The Galactic Center compared with nuclei of nearby galaxies

    CERN Document Server

    Combes, F

    2016-01-01

    Understanding our Galactic Center is easier with insights from nearby galactic nuclei. Both the star formation activity in nuclear gas disks, driven by bars and nuclear bars, and the fueling of low-luminosity AGN, followed by feedback of jets, driving molecular outflows, were certainly present in our Galactic Center, which appears now quenched. Comparisons and diagnostics are reviewed, in particular of m=2 and m=1 modes, lopsidedness, different disk orientations, and fossil evidences of activity and feedback.

  13. CDDIS Data Center Report

    Science.gov (United States)

    Noll, Carey E.

    2001-01-01

    This report summarizes activities for the year 2000 and future plans of the Crustal Dynamics Data Information System (CDDIS) with respect to the International Very Long Base Interferometry (VLBI) Service for Geodesy and Astrometry (IVS). Included in this report are background information about the CDDIS, the computer architecture, staffing supporting the system, archive contents, and future plans for the CDDIS within the IVS.

  14. TRAINING CENTERS OF A NEW TYPE

    OpenAIRE

    Roza Rakhmanbaeva

    2010-01-01

    Necessity for innovative production development sets the new requirements for content, organization, forms and methods of management activity. Non-traditional tasks faced by the present system of human resources management require the similar type of non-traditional methodological approaches and tools for social diagnosis, training and management of people in new situations. Therefore special attention should be also given to development of new type training centers that act as concentration ...

  15. Integrative Medicine Program- MD Anderson Cancer Center

    OpenAIRE

    Lee, Richard T.

    2012-01-01

    The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integr...

  16. Molecular Science Research Center 1992 annual report

    Energy Technology Data Exchange (ETDEWEB)

    Knotek, M.L.

    1994-01-01

    The Molecular Science Research Center is a designated national user facility, available to scientists from universities, industry, and other national laboratories. After an opening section, which includes conferences hosted, appointments, and projects, this document presents progress in the following fields: chemical structure and dynamics; environmental dynamics and simulation; macromolecular structure and dynamics; materials and interfaces; theory, modeling, and simulation; and computing and information sciences. Appendices are included: MSRC staff and associates, 1992 publications and presentations, activities, and acronyms and abbreviations.

  17. Stennis Space Center celebrates Diversity Day

    Science.gov (United States)

    2009-01-01

    Kendall Mitchell of the Naval Oceanographic Office (right) learns about the culture of Bolivia from Narda Inchausty, president of the Foreign Born Wives Association in Slidell, La., during 2009 Diversity Day events at NASA's John Stennis Space Center. Stennis hosted Diversity Day activities for employees on Oct. 7. The day's events included cultural and agency exhibits, diversity-related performances, a trivia contest and a classic car and motorcycle show. It also featured the first-ever sitewide Stennis Employee Showcase.

  18. Center for Neuroscience & Regenerative Medicine

    Data.gov (United States)

    Federal Laboratory Consortium — The Center for Neuroscience and Regenerative Medicine (CNRM) was established as a collaborative intramural federal program involving the U.S. Department of Defense...

  19. Consolidated Copayment Processing Center (CCPC)

    Data.gov (United States)

    Department of Veterans Affairs — The Consolidated Copayment Processing Center (CCPC) database contains Veteran patient contact and billing information in order to support the printing and mailing...

  20. Center for Environmental Health Sciences

    Data.gov (United States)

    Federal Laboratory Consortium — The primary research objective of the Center for Environmental Health Sciences (CEHS) at the University of Montana is to advance knowledge of environmental impacts...

  1. Energetics Manufacturing Technology Center (EMTC)

    Data.gov (United States)

    Federal Laboratory Consortium — The Energetics Manufacturing Technology Center (EMTC), established in 1994 by the Office of Naval Research (ONR) Manufacturing Technology (ManTech) Program, is Navy...

  2. Integrative Medicine Program- MD Anderson Cancer Center

    Directory of Open Access Journals (Sweden)

    Richard T Lee

    2012-06-01

    Full Text Available The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integrative Medicine Center provides clinical services to patients through individual and group programs.  The clinical philosophy of the center is to work collaboratively with the oncology teams to build comprehensive and integrative care plans that are personalized, evidence-based, and safe with the goal of improving clinical outcomes.  The individual services comprise of integrative oncology consultation, acupuncture, meditation, music therapy, nutrition, and oncology massage.  The center also provides a variety of group programs including meditation, yoga, tai chi, cooking classes and others.  Over the past 13 years, over 70,000 patients and families have participated in services and programs offered by the center.  The research portfolio focuses on three main areas: mind-body interventions, acupuncture, and meditation.  This lecture will focus on providing an overview of the Integrative Medicine Program at MD Anderson with a focus on the clinical services provided.  Participants will learn about the integrative clinical model and how this is applied to the care of cancer patients at MD Anderson Cancer Center.  Current and future research topics will be discussed as well as patient cases.

  3. Satellite medical centers project

    Science.gov (United States)

    Aggarwal, Arvind

    2002-08-01

    World class health care for common man at low affordable cost: anywhere, anytime The project envisages to set up a national network of satellite Medical centers. Each SMC would be manned by doctors, nurses and technicians, six doctors, six nurses, six technicians would be required to provide 24 hour cover, each SMC would operate 24 hours x 7 days. It would be equipped with the Digital telemedicine devices for capturing clinical patient information and investigations in the form of voice, images and data and create an audiovisual text file - a virtual Digital patient. Through the broad band connectivity the virtual patient can be sent to the central hub, manned by specialists, specialists from several specialists sitting together can view the virtual patient and provide a specialized opinion, they can see the virtual patient, see the examination on line through video conference or even PCs, talk to the patient and the doctor at the SMC and controlle capturing of information during examination and investigations of the patient at the SMC - thus creating a virtual Digital consultant at the SMC. Central hub shall be connected to the doctors and consultants in remote locations or tertiary care hospitals any where in the world, thus creating a virtual hub the hierarchical system shall provide upgradation of knowledge to thedoctors in central hub and smc and thus continued medical education and benefit the patient thru the world class treatment in the smc located at his door step. SMC shall be set up by franchisee who shall get safe business opportunity with high returns, patients shall get Low cost user friendly worldclass health care anywhere anytime, Doctors can get better meaningful selfemplyment with better earnings, flexibility of working time and place. SMC shall provide a wide variety of services from primary care to world class Global consultation for difficult patients.

  4. HEMISPHERIC CENTER FOR ENVIRONMENTAL TECHNOLOGY

    Energy Technology Data Exchange (ETDEWEB)

    M.A. Ebadian

    1999-10-31

    The Deactivation and Decommissioning (D&D) Technology Assessment Program (TAP) was developed to provide detailed, comparable data for environmental technologies and to disseminate this data to D&D professionals in a manner that will facilitate the review and selection of technologies to perform decontamination and decommissioning. The objectives for this project include the following: Determine technology needs through review of the Site Technology Coordination Group (STCG) information and other applicable websites and needs databases; Perform a detailed review of industries that perform similar activities as those required in D&D operations to identify additional technologies; Define the technology assessment program for characterization and waste management problem sets; Define the data management program for characterization, dismantlement, and waste management problem sets; Evaluate baseline and innovative technologies under standard test conditions at Florida International University's Hemispheric Center for Environmental Technology (FIU-HCET) and other locations and collect data in the areas of performance, cost, health and safety, operations and maintenance, and primary and secondary waste generation; Continue to locate, verify, and incorporate technology performance data from other sources into the multimedia information system; and Develop the conceptual design for a dismantlement technology decision analysis tool for dismantlement technologies.

  5. Clean Energy Application Center

    Energy Technology Data Exchange (ETDEWEB)

    Freihaut, Jim

    2013-09-30

    The Mid Atlantic Clean Energy Application Center (MACEAC), managed by The Penn State College of Engineering, serves the six states in the Mid-Atlantic region (Pennsylvania, New Jersey, Delaware, Maryland, Virginia and West Virginia) plus the District of Columbia. The goals of the Mid-Atlantic CEAC are to promote the adoption of Combined Heat and Power (CHP), Waste Heat Recovery (WHR) and District Energy Systems (DES) in the Mid Atlantic area through education and technical support to more than 1,200 regional industry and government representatives in the region. The successful promotion of these technologies by the MACEAC was accomplished through the following efforts; (1)The MACEAC developed a series of technology transfer networks with State energy and environmental offices, Association of Energy Engineers local chapters, local community development organizations, utilities and, Penn State Department of Architectural Engineering alumni and their firms to effectively educate local practitioners about the energy utilization, environmental and economic advantages of CHP, WHR and DES; (2) Completed assessments of the regional technical and market potential for CHP, WHR and DE technologies application in the context of state specific energy prices, state energy and efficiency portfolio development. The studies were completed for Pennsylvania, New Jersey and Maryland and included a set of incentive adoption probability models used as a to guide during implementation discussions with State energy policy makers; (3) Using the technical and market assessments and adoption incentive models, the Mid Atlantic CEAC developed regional strategic action plans for the promotion of CHP Application technology for Pennsylvania, New Jersey and Maryland; (4) The CHP market assessment and incentive adoption model information was discussed, on a continuing basis, with relevant state agencies, policy makers and Public Utility Commission organizations resulting in CHP favorable incentive

  6. Danish Chinese Center for Nanometals

    DEFF Research Database (Denmark)

    Winther, Grethe

    The Danish-Chinese Center for Nanometals is funded by the Danish National Research Foundation and the National Natural Science Foundation of China. The Chinese partners in the Center are Institute of Metal Research in Shenyang, Tsinghua University and Chongqing University. The Danish part...

  7. Acoustic Center or Time Origin?

    DEFF Research Database (Denmark)

    Staffeldt, Henrik

    1999-01-01

    The paper discusses the acoustic center in relation to measurements of loudspeaker polar data. Also, it presents the related concept time origin and discusses the deviation that appears between positions of the acoustic center found by wavefront based and time based measuring methods....

  8. Learning Centers: Development and Operation.

    Science.gov (United States)

    Bennie, Frances

    There has been in recent years a growing acceptance of individualized learning concepts. Learning Centers have come to be viewed as an economical and viable strategy for accommodating diverse learning styles and needs. This book provides the educator with an understanding of the learning center concept, its origins, present manifestations, and…

  9. National audit of drug information centers.

    Science.gov (United States)

    Dombrowski, S R; Visconti, J A

    1985-04-01

    A comprehensive audit of drug information centers (DICs) was conducted to obtain information on sources of funding, staffing, information resources, computerization, workload, and scope of services and activities and to examine the role of DICs in education, patient care, and research. Responses were obtained from 98 of the 121 DICs surveyed. The scope of activities and services varied considerably between centers and depended on such factors as source of funding, size of institution, academic affiliation, staffing, and workload. Many DICs are involved in writing newsletters, preparing information for pharmacy and therapeutics committee meetings, developing and updating formularies, and providing contract services to other organizations. The patient-care activities of DICs include providing consultations, performing drug-use reviews, monitoring adverse drug reactions, and coordinating investigational drug studies; DICs are also involved in training undergraduate and graduate pharmacy students and residents and conducting research projects. Large workloads and lack of time were cited most often as factors limiting DIC participation in patient-care, educational, and research activities. Because DICs are involved in a wide variety of educational, research, and patient-care activities, more emphasis should be placed on documenting the costs of these services in relation to their benefits to the institution. PMID:4014232

  10. Pengembangan Model Manajemen ICT Center

    Directory of Open Access Journals (Sweden)

    Hakkun Elmunsyah

    2013-01-01

    Full Text Available Abstrak: Pengembangan Model Manajemen ICT Center. Kemendiknas telah melakukan investasi  cukup besar berupa pembangunan Jejaring komputer pendidikan nasional yang disebut Jaringan Pendidikan Nasional (Jardiknas, pada sekolah menengah kejuruan (SMK di seluruh Indonesia yang dikenal dengan nama ICT center. Penelitian ini bertujuan untuk menemukan model manajemen ICT center sesuai karakteristik SMK sehingga dapat memberikan kontribusi mutu pada SMK tersebut. Penelitian ini merupakan penelitian pengembangan atau Research and Development yang dikembangkan oleh Borg and Gall. Hasil secara keseluruhan penelitian menunjukkan berdasarkan uji coba keefektivan kinerja manajemen pada skala terbatas dan lebih luas menunjukkan bahwa model manajemen ICT center memenuhi kriteria sangat efektif. Kata-kata kunci: Jardiknas, SMK, model manajemen ICT center, kontribusi mutu

  11. The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells

    OpenAIRE

    Whisenant, Thomas C.; Peralta, Eigen R.; Aarreberg, Lauren D.; Gao, Nina J.; Head, Steven R; Phillip Ordoukhanian; Jamie R Williamson; Salomon, Daniel R.

    2015-01-01

    Activation of CD4 T cells is a reaction to challenges such as microbial pathogens, cancer and toxins that defines adaptive immune responses. The roles of T cell receptor crosslinking, intracellular signaling, and transcription factor activation are well described, but the importance of post-transcriptional regulation by RNA-binding proteins (RBPs) has not been considered in depth. We describe a new model expanding and activating primary human CD4 T cells and applied this to characterizing act...

  12. Marine Renewable Energy Center

    Energy Technology Data Exchange (ETDEWEB)

    Vigeant, Paul [Univ. of Massachusetts, Dartmouth, MA (United States); Miller, John [Univ. of Massachusetts, Dartmouth, MA (United States); Howes, Brian [Univ. of Massachusetts, Dartmouth, MA (United States); McGowan, Jon G. [Univ. of Massachusetts, Amherst, MA (United States); Baldwin, Kenneth [Univ. of New Hampshire, Durham, NH (United States); Grilli, Annette [Univ. of Rhode Island, Kingston, RI (United States); Terray, Eugene [Woods Hole Oceanographic Inst., Woods Hole, MA (United States)

    2013-10-08

    Project Goals: The funding provided by this contract supported the following activities: A) Test Site Development; B) Seed Grant Funded Technology Development; C) Stakeholder Activities The first year of funding was dedicated to the formation of the NE MREC University Consortium which was comprised of University of Massachusetts Dartmouth (UMD) and Amherst (UMA), Massachusetts Institute of Technology (MIT), Woods Hole Oceanographic Institution (WHOI), University of New Hampshire (UNH), and the University of Rhode Island (URI). The consortium worked together to encourage research and promote benefits of obtaining energy from ocean wind, waves, tides and currents. In addition, NE MREC’s goal was to fund projects aimed at potential test sites with the first year funding going to studies of the potential for tidal device testing in Muskeget Channel, at the General Sullivan Bridge in New Hampshire, and for wave device testing at the proposed National Offshore Renewable Energy Innovation Zone (NOREIZ) located off the Massachusetts coast. The project spanned 4.5 years and addressed three specific tasks that are interrelated but also served as independent investigations.

  13. Sustainable Technology Research and Demonstration Center for Earth Structures

    Directory of Open Access Journals (Sweden)

    Judy Ueda

    2012-10-01

    Full Text Available This is a discussion paper that the authors presented at the International Workshop on Rammed Earth Materials and Sustainable Structures and Hakka Tulou Forum 2011: Structures of Sustainability, 28–31 October 2011, Xiamen University, China. A Sustainable Technology Research and Demonstration Center for Earth Structures is proposed to study, preserve, advance, promote, and implement rammed earth structures. The Center concept including the objectives, scope of activities and benefits of the proposed center are outlined. The Center for Alternative Technology in Wales, UK has been examined as a good base model along with a few successful environmental sustainability initiatives in China. The funding options to establish the proposed center have been discussed. The breadth of activities ultimately depends on funding capability. It is believed that the proposed center development will require significant government support at the initial stage but once corporate sponsorships are in place, the proposed center will potentially become self-supporting. The strategies, for the establishment of the proposed center are also addressed.

  14. Automated Data Submission for the Data Center

    Science.gov (United States)

    Wright, D.; Beaty, T.; Wei, Y.; Shanafield, H.; Santhana Vannan, S. K.

    2014-12-01

    Data centers struggle with difficulties related to data submission. Data are acquired through many avenues by many people. Many data submission activities involve intensive manual processes. During the submission process, data end up on varied storage devices. The situation can easily become chaotic. Collecting information on the status of pending data sets is arduous. For data providers, the submission process can be inconsistent and confusing. Scientists generally provide data from previous projects, and archival can be a low priority. Incomplete or poor documentation accompanies many data sets. However, complicated questionnaires deter busy data providers. At the ORNL DAAC, we have semi-automated the data set submission process to create a uniform data product and provide a consistent data provider experience. The formalized workflow makes archival faster for the data center and data set submission easier for data providers. Software modules create a flexible, reusable submission package. Formalized data set submission provides several benefits to the data center. A single data upload area provides one point of entry and ensures data are stored in a consistent location. A central dashboard records pending data set submissions in a single table and simplifies reporting. Flexible role management allows team members to readily coordinate and increases efficiency. Data products and metadata become uniform and easily maintained. As data and metadata standards change, modules can be modified or re-written without affecting workflow. While each data center has unique challenges, the data ingestion process is generally the same: get data from the provider, scientist, or project and capture metadata pertinent to that data. The ORNL DAAC data set submission workflow and software modules can be reused entirely or in part by other data centers looking for a data set submission solution. These data set submission modules will be available on NASA's Earthdata Code

  15. Industrial Assessment Center Program Impact Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Martin, M.A.

    2000-01-26

    This report presents the results of an evaluation of the U.S. Department of Energy's Industrial Assessment Center (IAC) Program. The purpose of this program is to conduct energy, waste, and productivity assessments for small to medium-sized industrial firms. Assessments are conducted by 30 university-based industrial assessment centers. The purpose of this project was to evaluate energy and cost savings attributable to the assessments, the trained alumni, and the Websites sponsored by this program. How IAC assessments, alumni, and Web-based information may influence industrial energy efficiency decision making was also studied. It is concluded that appreciable energy and cost savings may be attributed to the IAC Program and that the IAC Program has resulted in more active and improved energy-efficiency decision making by industrial firms.

  16. Telemetry Computer System at Wallops Flight Center

    Science.gov (United States)

    Bell, H.; Strock, J.

    1980-01-01

    This paper describes the Telemetry Computer System in operation at NASA's Wallops Flight Center for real-time or off-line processing, storage, and display of telemetry data from rockets and aircraft. The system accepts one or two PCM data streams and one FM multiplex, converting each type of data into computer format and merging time-of-day information. A data compressor merges the active streams, and removes redundant data if desired. Dual minicomputers process data for display, while storing information on computer tape for further processing. Real-time displays are located at the station, at the rocket launch control center, and in the aircraft control tower. The system is set up and run by standard telemetry software under control of engineers and technicians. Expansion capability is built into the system to take care of possible future requirements.

  17. Apparatuses and methods for tuning center frequencies

    Energy Technology Data Exchange (ETDEWEB)

    Wojciechowski, Kenneth; Olsson, Roy H.

    2016-02-23

    Apparatuses and methods for tuning center frequencies are described herein. Examples of tuning described herein including tuning using feedback from the resonator. Variable gain feedback for tuning of acoustic wave resonators is provided in some examples. An example apparatus may include a resonator and a feedback loop. The resonator may be configured to receive a tuning signal and to provide a feedback signal. The feedback signal may be based on the tuning signal. The feedback loop may be configured to receive the feedback signal from the resonator. The feedback loop further may be configured to provide the tuning signal to actively tune a center frequency of the resonator. The tuning signal may be based on the feedback signal.

  18. Marshall Space Flight Center Technology Investments Overview

    Science.gov (United States)

    Tinker, Mike

    2014-01-01

    NASA is moving forward with prioritized technology investments that will support NASA's exploration and science missions, while benefiting other Government agencies and the U.S. aerospace enterprise. center dotThe plan provides the guidance for NASA's space technology investments during the next four years, within the context of a 20-year horizon center dotThis plan will help ensure that NASA develops technologies that enable its 4 goals to: 1.Sustain and extend human activities in space, 2.Explore the structure, origin, and evolution of the solar system, and search for life past and present, 3.Expand our understanding of the Earth and the universe and have a direct and measurable impact on how we work and live, and 4.Energize domestic space enterprise and extend benefits of space for the Nation.

  19. Offshore Space Center (offshore launch site)

    Science.gov (United States)

    Harvey, D. G.

    1980-07-01

    Any activity requiring the development of the HLLV can benefit by operations from an offshore space center (OSC) since operating near the equator provides a twenty percent increase in payload in an ecliptic plan orbit. Some OSC concepts considered include a moored floating (semisubmersible) design, a stationary design supported by fixed piles, and a combination of these two. The facility supports: a 15,000 foot long, 300 foot wide runway, designed to accommodate a two staged winged launch vehicle, with a one million pound payload capacity to low earth orbit; an industrial area for HLLV maintenance; an airport terminal, control and operation center, and observation tower; liquid hydrogen and liquid oxygen production and storage, and fuel storage platforms; a power generation station, docks with an unloading area; two separate launch sites; and living accommodations for 10,000 people. Potential sites include the Paramount Seamount in the Pacific Ocean off the north coast of South America. Cost estimates are considered.

  20. Center for Beam Physics: 1994--95

    International Nuclear Information System (INIS)

    The Center for Beam Physics is a multidisciplinary research and development unit in the Accelerator and Fusion Research Division at the Lawrence Berkeley Laboratory of the University of California. At the heart of the Center's mission is a fundamental quest for mechanisms of acceleration, radiation, transport, and focusing of energy and information. Dedicated to exploring the frontiers of particle and photon beam physics, its primary mission is to promote the science and technology of the production, manipulation, storage, and control of systems of charged particles and photons. This roster and annual report provides a glimpse of the scientists, engineers, technical support, students, and administrative staff that make up the CBP's team and gives a brief review of the multifaceted activities during 1994 and 1995