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  1. APLICATIVO INFORMATIZADO COM O NURSING ACTIVITIES SCORE: INSTRUMENTO PARA GERENCIAMENTO DA ASSISTÊNCIA EM UNIDADE DE TERAPIA INTENSIVA

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    Meire Cristina Novelli e Castro

    2009-01-01

    Full Text Available La gravedad de la enfermedad del paciente o el número de intervenciones no son siempre proporcionales a la carga de trabajo de la enfermería. Este estudio descriptivo tuvo como objetivo demostrar la trayectoria de la construcción de un aplicativo (software con el contenido del Nursing Activities Score y sus características operacionales. Se realizó un test piloto con 12 pacientes y se recolectaron los datos por 90 días consecutivos en 123 pacientes. Hubo compatibilidad en la transmisión de datos del Personal Digital Assistent para la computadora de mesa inalámbrica. La construcción del aplicativo resultó en un sistema con recolección y administración de datos y permitió realizar la interfaz gráfica. La utilización del aplicativo posibilita el uso de un sistema tecnológico para aplicación diaria, con alimentación de un banco de datos sobre las características de los cuidados requeridos. Conociendo la evolución de estas variables durante la hospitalización, el enfermero podrá planificar, intervenir y evaluar la calidad del cuidado.

  2. Sítios assistenciais em Unidade de Terapia Intensiva e relação do nursing activities score com a infecção hospitalar Sitios asistenciales en la Unidad de Terapia Intensiva y la relación de nursing activities score con la infección hospitalaria Assistance sites in the Intensive Care Unit and the relation from nursing activities score with the hospital infection

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    Claudia Maria Silva Cyrino

    2012-12-01

    Full Text Available O Sistema de Classificação de Pacientes tornou-se essencial na prática gerencial e assistencial do enfermeiro. Este estudo analisou a implantação de Sítios Assistenciais na Unidade de Terapia Intensiva Adulto como forma de organização e classificação de pacientes, bem como suas implicações na qualidade do cuidado de acordo com o Nursing Activities Score e a relação com a Infecção Hospitalar. Trata-se de um estudo quantitativo, prospectivo, descritivo e transversal. A coleta foi realizada de julho a outubro de 2010. A amostra foi constituída por 214 pacientes, a maioria do sexo masculino, de neurocirurgia e com idade média de 57 anos. O Nursing Activities Score médio foi de 71,72%. Com relação à Infecção Hospitalar antes e após a implantação, houve redução nas taxas de pneumonia, porém, a carga de trabalho de enfermagem permaneceu constante. Ficou evidenciada a importância da utilização do Nursing Activities Score como indicador e da implantação de novas formas de classificação de pacientes para melhorar a organização da assistência.El Sistema de Clasificación de Pacientes se tornó esencial para la práctica gerencial y asistencial del enfermero. Este estudio analizó la implantación de Sitios Asistenciales en la Unidad de Terapia Intensiva Adulta como forma de organización y clasificación de pacientes, bien como sus implicaciones en la calidad del cuidado de acuerdo con el Nursing Activities Score y la relación con Infección Hospitalaria. Se trata del estudio cuantitativo, prospectivo, descriptivo y transversal. La colección de datos fue realizada de julio a octubre de 2010. La muestra fue constituida por 214 pacientes, la mayoría hombres, neurocirúrgicos y con edad media de 57 años. El Nursing Activities Score medio fue 71,72%. Con relación a la Infección Hospitalaria hubo reducción en los niveles de Neumonía, sin embargo, la carga de trabajo de enfermería permaneció constante. Qued

  3. Three New Myrsinol Diterpenes from <em>Euphorbia proliferaem> and Their Neuroprotective Activities

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    Yuanqiang Guo

    2012-08-01

    Full Text Available Three new myrsinol diterpenes were isolated from the roots of<em> em>>Euphorbia proliferaem>. Their structures were elucidated as 2<em>α-O>-isobutyryl-3<em>β>,5<em>α>,7<em>β>,10,15<em>β-penta-O>-acetyl-14<em>α-O>-benzoyl-10,18-dihydromyrsinol (1, 2<em>α-O>-isobutyryl-3<em>β-O>-propion-yl-5<em>α>,7<em>β>,10,15<em>β-tetra-O>-acetyl-10,18-dihydromyrsinol (2, and 2<em>α>,14<em>α-di-O>-benzoyl-3<em>β>,5<em>α>,7<em>β>,10,15<em>β-penta-O>-acetyl-10,18-dihydromyrsinol (3 on the basis of spectroscopic data analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR. Their neuroprotective activities were evaluated and compounds 1 and 2 showed neuroprotective effects against MPP+-induced neuronal cell death in SH-SY5Y cells.

  4. Antimicrobial Activity of Geranium Oil against Clinical Strains<em> em>of <em>Staphylococcus aureusem>

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    Monika Sienkiewicz

    2012-08-01

    Full Text Available The aim of this work was to investigate the antibacterial properties of geranium oil obtained from <em>Pelargonium graveolensem> Ait. (family <em>Geraniaceae>, against one standard <em>S. aureus em>strain ATCC 433000 and seventy clinical <em>S. aureusem> strains. The agar dilution method was used for assessment of bacterial growth inhibition at various concentrations of geranium oil. Susceptibility testing of the clinical strains to antibiotics was carried out using the disk-diffusion and E-test methods. The results of our experiment showed that the oil from <em>P. graveolensem> has strong activity against all of the clinical <em>S. aureusem> isolates—including multidrug resistant strains, MRSA strains and MLSB-positive strains—exhibiting MIC values of 0.25–2.50 μL/mL.

  5. The Disease Activity Score and the EULAR response criteria.

    NARCIS (Netherlands)

    Fransen, J.; Riel, P.L.C.M. van

    2005-01-01

    In rheumatoid arthritis (RA), inflammatory activity cannot be measured using one single variable. For this reason the Disease Activity Score (DAS). has been developed. The DAS is a clinical index of RA disease activity that combines information from swollen joints, tender joints, the acute phase res

  6. The Disease Activity Score and the EULAR response criteria.

    NARCIS (Netherlands)

    Fransen, J.; Riel, P.L.C.M. van

    2009-01-01

    The Disease Activity Score (DAS), its modified version the DAS28, and the DAS-based European League Against Rheumatism (EULAR) response criteria are well-known measures of disease activity in rheumatoid arthritis (RA). The DAS is a clinical index of RA disease activity that combines information from

  7. Neonatal Phosphate Nutrition Alters <em>in em>Vivo> and <em>in em>Vitro> Satellite Cell Activity in Pigs

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    Chad H. Stahl

    2012-05-01

    Full Text Available Satellite cell activity is necessary for postnatal skeletal muscle growth. Severe phosphate (PO4 deficiency can alter satellite cell activity, however the role of neonatal PO4 nutrition on satellite cell biology remains obscure. Twenty-one piglets (1 day of age, 1.8 ± 0.2 kg BW were pair-fed liquid diets that were either PO4 adequate (0.9% total P, supra-adequate (1.2% total P in PO4 requirement or deficient (0.7% total P in PO4 content for 12 days. Body weight was recorded daily and blood samples collected every 6 days. At day 12, pigs were orally dosed with BrdU and 12 h later, satellite cells were isolated. Satellite cells were also cultured <em>in vitroem> for 7 days to determine if PO4 nutrition alters their ability to proceed through their myogenic lineage. Dietary PO4 deficiency resulted in reduced (<em>P> < 0.05 sera PO4 and parathyroid hormone (PTH concentrations, while supra-adequate dietary PO4 improved (<em>P> < 0.05 feed conversion efficiency as compared to the PO4 adequate group. <em>In vivoem> satellite cell proliferation was reduced (<em>P> < 0.05 among the PO4 deficient pigs, and these cells had altered <em>in vitroem> expression of markers of myogenic progression. Further work to better understand early nutritional programming of satellite cells and the potential benefits of emphasizing early PO4 nutrition for future lean growth potential is warranted.

  8. Validity of the disease activity score in undifferentiated arthritis.

    NARCIS (Netherlands)

    Fransen, J.; Visser, K.; Dongen, H. van; Huizinga, T.; Riel, P.L.C.M. van; Heijde, D.M.F.M. van der

    2010-01-01

    OBJECTIVE: To study whether the Disease Activity Score (DAS) is a valid measure of disease activity in undifferentiated arthritis (UA). METHODS: Data from a randomized, double-blind, placebo-controlled trial of methotrexate (MTX) and placebo involving 110 patients with UA were used. Data included ba

  9. Pemphigus Vulgaris Activity Score and Assessment of Convergent Validity

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    Cheyda Chams-Davatchi

    2013-04-01

    Full Text Available Pemphigus is a rare autoimmune blistering disease with different phenotypes. The evaluation of therapeutic interventions requires a reliable, valid and feasible to use measurement. However, there is no gold standard to measure the disease activity in clinical trials. In this study we aimed to introduce the pemphigus vulgaris activity score (PVAS measurement and to assess the convergent validity with the experts’ opinion of disease activity. In PVAS scoring, the distribution of pemphigus vulgaris antigen expression in different anatomical regions is taking in to account with special consideration of the healing process. PVAS is a 0-18 scale, based on the extent of mucocutaneous involvement, type of lesion and the presence of Nikolsky’s sign. The sum of the scores of total number of lesions, number of different anatomic regions involvement and Nikolsky’s sign is weighted by the type of lesion. In the present study, PVAS was assessed in 50 patients diagnosed with pemphigus vulgaris by one dermatologist. Independently, five blinded experts scored all the patients through physician’s global assessment (PGA. The convergent validity with experts’ opinion was assessed. The Spearman coefficient of correlation showed the acceptable value of 0.751 (95%CI: 0.534- 0.876. PVAS is a valid, objective and simple-to-use scoring measurement. It showed a good correlation with PGA of pemphigus disease activity in Iranian patients with pemphigus vulgaris

  10. Pemphigus vulgaris activity score and assessment of convergent validity.

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    Chams-Davatchi, Cheyda; Rahbar, Ziba; Daneshpazhooh, Maryam; Mortazavizadeh, Seyed Mohammad Ali; Akhyani, Maryam; Esmaili, Nafiseh; Balighi, Kamran

    2013-05-07

    Pemphigus is a rare autoimmune blistering disease with different phenotypes. The evaluation of therapeutic interventions requires a reliable, valid and feasible to use measurement. However, there is no gold standard to measure the disease activity in clinical trials. In this study we aimed to introduce the pemphigus vulgaris activity score (PVAS) measurement and to assess the convergent validity with the experts' opinion of disease activity. In PVAS scoring, the distribution of pemphigus vulgaris antigen expression in different anatomical regions is taking in to account with special consideration of the healing process. PVAS is a 0-18 scale, based on the extent of mucocutaneous involvement, type of lesion and the presence of Nikolsky's sign. The sum of the scores of total number of lesions, number of different anatomic regions involvement and Nikolsky's sign is weighted by the type of lesion. In the present study, PVAS was assessed in 50 patients diagnosed with pemphigus vulgaris by one dermatologist. Independently, five blinded experts scored all the patients through physician's global assessment (PGA). The convergent validity with experts' opinion was assessed. The Spearman coefficient of correlation showed the acceptable value of 0.751 (95%CI: 0.534- 0.876). PVAS is a valid, objective and simple-to-use scoring measurement. It showed a good correlation with PGA of pemphigus disease activity in Iranian patients with pemphigus vulgaris.

  11. Study of the <em>in Vitroem> Antiplasmodial, Antileishmanial and Antitrypanosomal Activities of Medicinal Plants from Saudi Arabia

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    Nawal M. Al-Musayeib

    2012-09-01

    Full Text Available The present study investigated the <em>in vitroem> antiprotozoal activity of sixteen selected medicinal plants. Plant materials were extracted with methanol and screened <em>in vitroem> against erythrocytic schizonts of <em>Plasmodium falciparumem>, intracellular amastigotes of <em>Leishmania infantum em>and <em>Trypanosoma cruzi em>and free trypomastigotes of<em> T. bruceiem>. Cytotoxic activity was determined against MRC-5 cells to assess selectivity<em>. em>The criterion for activity was an IC50 < 10 µg/mL (4. Antiplasmodial activity was found in the<em> em>extracts of<em> em>>Prosopis julifloraem> and <em>Punica granatumem>. Antileishmanial activity> em>against <em>L. infantumem> was demonstrated in <em>Caralluma sinaicaem> and <em>Periploca aphylla.em> Amastigotes of<em> T. cruzi em>were affected by the methanol extract of<em> em>>Albizia lebbeckem>> em>pericarp, <em>Caralluma sinaicaem>,> Periploca aphylla em>and <em>Prosopius julifloraem>. Activity against<em> T. brucei em>was obtained in<em> em>>Prosopis julifloraem>. Cytotoxicity (MRC-5 IC50 < 10 µg/mL and hence non-specific activities were observed for<em> em>>Conocarpus lancifoliusem>.>

  12. Influence of activity on quality of life scores after RYGBP.

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    Forbush, Steven W; Nof, Leah; Echternach, John; Hill, Cheryl

    2011-08-01

    Gastric bypass is one of the medically acceptable interventions for weight loss for the obese. Quality of life greatly improves after surgery. Most improvements in quality of life (QOL) after these surgeries are attributed to the weight loss. Few studies have demonstrated any contribution of other variables to positive outcomes in QOL. The purpose of this study was to suggest variables that improve QOL in this post-surgical population. The Arizona Activity Frequency Questionnaire, the Arizona Food Frequency Questionnaire, and the SF-36 survey were sent to all of the Roux-en-Y gastric bypass procedure (RYGBP) patients who had surgery 1-5 years prior to the study and performed through the same bariatric surgery center (n = 805; respondents = 265; 33%). Analysis was performed through ANOVA testing to determine relationships between selected behaviors and the SF-36 of the respondents. Comparisons of differences in SF-36 scores were analyzed using the variables of hours of activity/day (HOAD) and energy in activity/day (EEAD). Patients with more EEAD and HOAD demonstrated significantly better SF-36 scores in both mental component and physical component scores (p = 0.05) when compared to those with less EEAD or HOAD. Outcomes measured by the SF-36 tool were improved after RYGBP, if the patient expended more energy/day or was active more hours/day. The post-bariatric surgery populations will have improved QOL if the patients expend more energy and are active more hours as demonstrated in activity/day after their surgery.

  13. Constituents from <em>Vigna em>vexillata> and Their Anti-Inflammatory Activity

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    Guo-Feng Chen

    2012-08-01

    Full Text Available The seeds of <em>Vigna em>genus are important food resources and there have already been many reports regarding their bioactivities. In our preliminary bioassay, the chloroform layer of methanol extracts of<em> V. vexillata em>demonstrated significant anti-inflammatory bioactivity. Therefore, the present research is aimed to purify and identify the anti-inflammatory principles of <em>V. vexillataem>. One new sterol (1 and two new isoflavones (2,3 were reported from the natural sources for the first time and their chemical structures were determined by the spectroscopic and mass spectrometric analyses. In addition, 37 known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. Among the isolates, daidzein (23, abscisic acid (25, and quercetin (40 displayed the most significant inhibition of superoxide anion generation and elastase release.

  14. [The NAS system: Nursing Activities Score in mobile technology].

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    Catalan, Vanessa Menezes; Silveira, Denise Tolfo; Neutzling, Agnes Ludwig; Martinato, Luísa Helena Machado; Borges, Gilberto Cabral de Mello

    2011-12-01

    The objective of this study was to present the computerized structure that enables the use of the Nursing Activities Score (NAS) in mobile technology. It is a project for the development of technology production based on software engineering, founded on the theory of systems development life cycle. The NAS system was built in two modules: the search module, which is accessed using a personal computer (PC), and Data Collection module, which is accessed through a mobile device (Smartphone). The NAS system was constructed to allow other forms, in addition to the NAS tool, to be included in the future. Thus, it is understood that the development of the NAS will bring nurses closer to mobile technology and facilitate their accessibility to the data of the instrument relating to patients, thus assisting in decision-making and in staffing to provide nursing care.

  15. Activity-Guided Isolation of Antioxidant Compounds from <em>Rhizophora apiculataem>

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    Hongbin Xiao

    2012-09-01

    Full Text Available <em>Rhizophora apiculataem> (<em>R. apiculataem> contains an abundance of biologically active compounds due its special salt-tolerant living surroundings. In this study, the total phenolic content and antioxidant activities of various extract and fractions of stem of <em>R. apiculataem> were investigated. Results indicated that butanol fraction possesses the highest total phenolic content (181.84 mg/g GAE/g dry extract with strongest antioxidant abilities. Following <em>in vitroem> antioxidant activity-guided phytochemical separation procedures, lyoniresinol-3α-<em>O>-β-arabinopyranoside (1, lyoniresinol-3α-<em>O>-β-rhamnoside (2, and afzelechin-3-<em>O>-L-rhamno-pyranoside (3 were separated from the butanol fraction. These compounds showed more noticeable antioxidant activity than a BHT standard in the DPPH, ABTS and hydroxyl radical scavenging assays. HPLC analysis results showed that among different plant parts, the highest content of 13 was located in the bark (0.068%, 0.066% and 0.011%, respectively. The results imply that the <em>R. apiculataem> might be a potential source of natural antioxidants and 13 are antioxidant ingredients in <em>R. apiculataem>.

  16. Auditory short-term memory activation during score reading.

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    Veerle L Simoens

    Full Text Available Performing music on the basis of reading a score requires reading ahead of what is being played in order to anticipate the necessary actions to produce the notes. Score reading thus not only involves the decoding of a visual score and the comparison to the auditory feedback, but also short-term storage of the musical information due to the delay of the auditory feedback during reading ahead. This study investigates the mechanisms of encoding of musical information in short-term memory during such a complicated procedure. There were three parts in this study. First, professional musicians participated in an electroencephalographic (EEG experiment to study the slow wave potentials during a time interval of short-term memory storage in a situation that requires cross-modal translation and short-term storage of visual material to be compared with delayed auditory material, as it is the case in music score reading. This delayed visual-to-auditory matching task was compared with delayed visual-visual and auditory-auditory matching tasks in terms of EEG topography and voltage amplitudes. Second, an additional behavioural experiment was performed to determine which type of distractor would be the most interfering with the score reading-like task. Third, the self-reported strategies of the participants were also analyzed. All three parts of this study point towards the same conclusion according to which during music score reading, the musician most likely first translates the visual score into an auditory cue, probably starting around 700 or 1300 ms, ready for storage and delayed comparison with the auditory feedback.

  17. Antioxidant Activity of Various Parts of <em>Cinnamomum> cassiaem> Extracted with Different Extraction Methods

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    Li-Yeh Chuang

    2012-06-01

    Full Text Available The aim of this study was to investigate the antioxidant activities of various parts (barks, buds, and leaves of <em>Cinnamomum cassia em>extracted with ethanol and supercritical fluid extraction (SFE. For the antioxidant activity comparison, IC50 values of the SFE and ethanol extracts in the DPPH scavenging assay were 0.562–10.090 mg/mL and 0.072–0.208 mg/mL, and the Trolox equivalent antioxidant capacity (TEAC values were 6.789–58.335 mmole Trolox/g and 133.039–335.779 mmole Trolox/g, respectively. In addition, the total flavonoid contents were 0.031–1.916 g/ 100 g dry weight of materials (DW and 2.030–3.348 g/ 100 g DW, and the total phenolic contents were 0.151–2.018 g/ 100 g DW and 6.313–9.534 g/ 100 g DW in the SFE and ethanol extracts, respectively. Based on the results, the ethanol extracts of <em>Cinnamon> barks have potential value as an antioxidant substitute and this study also provide a better technique to extract the natural antioxidant substances from <em>C. cassiaem>.

  18. <em>N>-Substituted 5-Chloro-6-phenylpyridazin-3(2<em>H>-ones: Synthesis, Insecticidal Activity Against <em>Plutella xylostella em>(L. and SAR Study

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    Song Yang

    2012-08-01

    Full Text Available A series of <em>N>-substituted 5-chloro-6-phenylpyridazin-3(2<em>H>-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for <em>in vitroem> insecticidal activity against <em>Plutella xylostellaem>. The results showed that the synthesized pyridazin-3(2<em>H>-one compounds possessed good insecticidal activities, especially the compounds 4b, 4d, and 4h which showed > 90% activity at 100 mg/L. The structure-activity relationships (SAR for these compounds were also discussed.

  19. Methodological issues in the design of a rheumatoid arthritis activity score and its cut-offs

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    Collignon O

    2014-07-01

    Full Text Available Olivier Collignon Centre de Recherche Public de la Santé (CRP-Santé, Competences Centre for Methodology and Statistics (CCMS, Strassen, Luxembourg Abstract: Activity of rheumatoid arthritis (RA can be evaluated using several scoring scales based on clinical features. The most widely used one is the Disease Activity Score involving 28 joint counts (DAS28 for which cut-offs were proposed to help physicians classify patients. However, inaccurate scoring can lead to inappropriate medical decisions. In this article some methodological issues in the design of such a score and its cut-offs are highlighted in order to further propose a strategy to overcome them. As long as the issues reviewed in this article are not addressed, results of studies based on standard disease activity scores such as DAS28 should be considered with caution. Keywords: DAS28, disease activity score, penalized logistic regression, clinical prediction, modeling

  20. Antifungal Activity, Toxicity and Chemical Composition of the Essential Oil of <em>Coriandrum sativumem> L. Fruits

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    Erika H. S. Brito

    2012-07-01

    Full Text Available The aims of this study were to test the antifungal activity, toxicity and chemical composition of essential oil from <em>C. sativumem> L. fruits. The essential oil, obtained by hydro-distillation, was analyzed by gas chromatography/mass spectroscopy. Linalool was the main constituent (58.22%. The oil was considered bioactive, showing an LC50 value of 23 µg/mL in the <em>Artemia salinaem> lethality test. The antifungal activity was evaluated against <em>Microsporum canisem> and <em>Candida> spp. by the agar-well diffusion method and the minimum inhibitory concentration (MIC and the minimum fungicidal concentration (MFC were established by the broth microdilution method. The essential oil induced growth inhibition zones of 28 ± 5.42 and 9.25 ± 0.5 for <em>M. canisem> and <em>Candida> spp. respectively. The MICs and MFCs for <em>M. canisem> strains ranged from 78 to 620 and 150 to 1,250 µg/mL, and the MICs and MFCs for <em>Candida> spp strains ranged from 310 to 620 and 620 to 1,250 µg/mL, respectively. <em>C. sativumem> essential oil is active> in vitroem> against <em>M. canis em>and> Candidaem> spp. demonstrating good antifungal activity.

  1. Development and validation of modified disease activity scores in rheumatoid arthritis

    DEFF Research Database (Denmark)

    Baker, Joshua F; Conaghan, Philip G; Smolen, Josef S

    2014-01-01

    -CDAI) were generated for each subject in the validation cohort. The M-DAS28, M-SDAI, and M-CDAI scores were compared to conventional scores of disease activity with regard to associations with MRI measures of synovitis and radiographic progression, assessed using Pearson's and Spearman's correlations, linear......OBJECTIVE: To develop and validate composite disease activity scores, based on widely available clinical measures, that would demonstrate improved correlation with detection of synovitis on magnetic resonance imaging (MRI) and radiographic progression, in comparison with conventional measures.......15 × SJC28 + 0.22 × EvGA + 1 and M-SDAI = CRP + SJC28 + EvGA. Both modified and conventional disease activity scores correlated significantly with MRI measures of synovitis. Modified scores showed superior correlation with synovitis, as compared to conventional scores, at all time points (P

  2. Scoring inflammatory activity of the spine by magnetic resonance imaging in ankylosing spondylitis: a multireader experiment

    DEFF Research Database (Denmark)

    Lukas, Cédric; Braun, Jürgen; van der Heijde, Désirée

    2007-01-01

    OBJECTIVE: Magnetic resonance imaging (MRI) of the spine is increasingly important in the assessment of inflammatory activity in clinical trials with patients with ankylosing spondylitis (AS). We investigated feasibility, inter-reader reliability, sensitivity to change, and discriminatory ability...... the Ankylosing Spondylitis spine Magnetic Resonance Imaging-activity [ASspiMRI-a, grading activity (0-6) per vertebral unit in 23 units]; the Berlin modification of the ASspiMRI-a; and the Spondyloarthritis Research Consortium of Canada (SPARCC) scoring system, which scores the 6 vertebral units considered......) assessed by Z-scores was good and comparable among methods. CONCLUSION: This experiment demonstrates the feasibility of multiple-reader MRI scoring exercises for method comparison, provides evidence for the feasibility, reliability, sensitivity to change, and discriminatory capacity of all 3 tested scoring...

  3. Valor prognóstico do Escore de Risco GRACE versus Escore de Risco TIMI em síndromes coronarianas agudas Valor pronóstico del score de riesgo GRACE versus score de riesgo TIMI en síndromes coronarios agudos Prognostic Value of GRACE Scores versus TIMI Score in acute coronary syndromes

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    Luis C. L. Correia

    2010-05-01

    Full Text Available FUNDAMENTO: Embora o Escore de Risco TIMI seja o mais utilizado em síndromes coronarianas agudas sem supradesnível do segmento ST (SCA, o Escore GRACE tem potencial superioridade prognóstica, pois foi criado a partir de um registro observacional, parte das variáveis são tratadas de forma semiquantitativa e a função renal é computada em seu cálculo. OBJETIVO: Testar a hipótese de que o Escore de Risco GRACE tem superior valor prognóstico hospitalar, comparado ao Escore TIMI em pacientes admitidos com SCA. MÉTODOS: Foram incluídos indivíduos com angina instável ou infarto do miocárdio sem supradesnível do segmento ST, consecutivamente internados em unidade coronariana entre agosto de 2007 e janeiro de 2009. RESULTADOS: Foram estudados 154 pacientes, idade 71 ± 13 anos, 56% do gênero feminino, mediana do GRACE de 117 e mediana do TIMI de 3. Durante o período de internamento, a incidência de eventos foi 8,4% (12 óbitos e 1 infarto não fatal. O teste de Hosmer-Lemeshow aplicado ao Escore GRACE apresentou χ2 de 5,3 (P = 0,72, enquanto Escore TIMI apresentou χ2 de 1,85 (P = 0,60. Desta forma, ambos os escores apresentaram boa calibração. Quanto à análise de discriminação, o Escore GRACE apresentou estatística-C de 0,91 (95% IC = 0,86 - 0,97, significativamente superior à estatística-C de 0,69 do Escore TIMI (95% IC = 0,55 - 0,84 - P = 0,02 para diferença entre os escores. CONCLUSÃO: Em relação à predição de eventos hospitalares em pacientes com SCA, o Escore GRACE tem superior capacidade prognóstica quando comparado ao Escore TIMI.FUNDAMENTO: Aunque el Score de Riesgo TIMI sea el más utilizado en síndromes coronarios agudos sin supradesnivel del segmento ST (SCA, el Score GRACE tiene potencial superioridad pronóstica, pues fue creado a partir de un registro observacional, parte de las variables son tratadas de forma semicuantitativa y la función renal se computa en su cálculo. OBJETIVO: Probar la hip

  4. Financial Distress Situation of Listed Malaysian Shipping Companies from 2008 to 2014: Using Altman’s Z- EM Score

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    Saravanan Venkadasalam

    2016-05-01

    Full Text Available The main purpose of this paper is to analyse the financial distress situation of Listed Malaysian shipping companies. This paper also analyses the relationship of the company performance with financial distress variables. A secondary data of selected shipping andtransportation service provider’s annual reports from 2008 to 2014 were retrieved from Kuala Lumpur Stock Exchange website. A panel data analysis using Altman’s Z- EM score model and least squares dummy variable (LSDV model were performed. Findings reveal that most of the shipping companies in Malaysia are suffering from the burden of the financial crisis. Ordinary least squares T-tests revealed a significant positive relationship between financial variables and company performance.

  5. Chemical Composition<em> em>of Hexane Extract of <em>Citrus aurantifoliaem> and<em> em>Anti->Mycobacterium tuberculosisem> Activity of Some of Its Constituents

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    María del Rayo Camacho-Corona

    2012-09-01

    Full Text Available The main aim of this study was to isolate and characterize the active compounds from the hexane extract of the fruit peels of <em>Citrus aurantiifoliaem>, which showed activity against one sensitive and three monoresistant (isoniazid, streptomycin or ethambutol strains of <em>Mycobacterium tuberculosis em>H37Rv. The active extract was fractionated by column chromatography, yielding the following major compounds: 5-geranyloxypsoralen (1; 5-geranyloxy-7-methoxycoumarin (2; 5,7-dimethoxycoumarin (3; 5-methoxypsoralen (4; and 5,8-dimethoxypsoralen (5. The structures of these compounds were elucidated by 1D and 2D NMR spectroscopy. In addition, GC-MS analysis of the hexane extract allowed the identification of 44 volatile compounds, being 5,7-dimethoxycoumarin (15.79%, 3-methyl-1,2-cyclopentanedione (8.27%, 1-methoxy-ciclohexene (8.0%, corylone (6.93%, palmitic acid (6.89%, 5,8-dimethoxypsoralen (6.08%, a-terpineol (5.97%, and umbelliferone (4.36%, the major constituents. Four isolated coumarins and 16 commercial compounds identified by GC-MS were tested against <em>M. tuberculosisem> H37Rv and three multidrug-resistant <em>M. tuberculosisem> strains using the Microplate Alamar Blue Assay. The constituents that showed activity against all strains were 5 (MICs = 25–50 mg/mL, 1 (MICs = 50–100 mg/mL, palmitic acid (MICs = 25–50 mg/mL, linoleic acid (MICs = 50–100 mg/mL, oleic acid (MICs = 100 mg/mL, 4-hexen-3-one (MICs = 50–100 mg/mL, and citral (MICs = 50–100 mg/mL. Compound 5 and palmitic acid were the most active ones. The antimycobacterial activity of the hexane extract of <em>C. aurantifoliaem> could be attributed to these compounds.

  6. Platelet-Activating Factor (PAF Antagonistic Activity of a New Biflavonoid from <em>Garcinia nervosaem> var. <em>pubescens> King

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    Azura Abdul Ghani

    2012-09-01

    Full Text Available The methanol extract of the leaves of <em>Garcinia nervosaem> var. <em>pubescens> King, which showed strong inhibitory effects on platelet-activating factor (PAF receptor binding, was subjected to bioassay-guided isolation to obtain a new biflavonoid, II-3,I-5, II-5,II-7,I-4',II-4'-hexahydroxy-(I-3,II-8-flavonylflavanonol together with two known flavonoids, 6-methyl-4'-methoxyflavone and acacetin. The structures of the compounds were elucidated by spectroscopic methods. The compounds were evaluated for their ability to inhibit PAF receptor binding to rabbit platelets using 3H-PAF as a ligand. The biflavonoid and acacetin showed strong inhibition with IC50 values of 28.0 and 20.4 µM, respectively. The results suggest that these compounds could be responsible for the strong PAF antagonistic activity of the plant.

  7. Phenolic Compounds and Antioxidant Activity of Bulb Extracts of Six <em>Lilium> Species Native to China

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    Lixin Niu

    2012-08-01

    Full Text Available Lily (<em>Lilium> is used as an important edible and medical plant species with a vague taxonomic classification and a long history in China. Bulbs of six <em>Lilium> species (<em>L. regaleem>,> L. concolorem>,> L. pumilumem>,> L. leucanthumem>,> L. davidii var. unicolorem> and <em>L. lancifoliumem> native to China were investigated with a view to their exploitation as a potential source of natural antioxidants due to their phenolic composition and dietary antioxidant potential. The results showed that all bulb extracts exhibited strong antioxidant activities, which generally correlated positively with the total phenolic contents (r = 0.68 to 0.94, total flavonoid contents (r = 0.51 to 0.89 and total flavanol contents (r = 0.54 to 0.95. High-performance liquid chromatography (HPLC analysis revealed that rutin and kaempferol were the major phenolic components in the extracts. Hierarchical cluster analysis showed that <em>L. regaleem> belonged to the group with high phenolic content and strong antioxidant power. <em>L. concolorem> and <em>L. pumilumem> were arranged in one group characterized by moderate phenolic content and antioxidant capacity, while <em>L. leucanthumem>, <em>L. davidii var. unicolorem> and <em>L. lancifoliumem> were clustered in the third group with low phenolic content and weak antioxidant activity. These strongly suggest that lily bulbs may serve as a potential source of natural antioxidant for food and pharmaceutical applications.

  8. Antimycobacterial Activity of Constituents from <em>Foeniculum vulgareem> Var. Dulce Grown in Mexico

    Directory of Open Access Journals (Sweden)

    María del Rayo Camacho-Corona

    2012-07-01

    Full Text Available Bioassay guided fractionation of an antimycobacterial extract of <em>Foeniculum vulgareem> var dulce (Apiaceae led to the isolation and characterization of 5-hydroxyfurano-coumarin. The chemical structure of this compound was elucidated by 1H and 13C (1D and 2D Nuclear Magnetic Resonance (NMR spectroscopy. In addition, the active fractions were analyzed by GC-MS and seventy eight compounds were identified; the major compounds were 1,3-benzenediol, 1-methoxycyclohexene, <em>o>-cymene, sorbic acid, 2-hydroxy-3-methyl-2-cyclopenten-1-one, estragole, limonene-10-ol and 3-methyl-2-cyclopenten-1-one. Twenty compounds identified in the active fractions were tested against one sensitive and three MDR strains of <em>Mycobacterium tuberculosis em>using the Alamar Blue microassay. Compounds that showed some degree of antimycobacterial activity against all strains tested were the following: linoleic acid (MIC 100 µg/mL, oleic acid (MIC 100 µg/mL, 1,3-benzenediol (MIC 100–200 µg/mL, undecanal (MIC 50–200 µg/mL, and 2,4-undecadienal (MIC 25–50 µg/mL, the last being the most active compound. To our knowledge, this is the first report of the presence of 5-hydroxy-furanocoumarin in <em>F. vulgareem>.

  9. Load-specific physical activity scores are related to tibia bone architecture.

    Science.gov (United States)

    Kindler, Joseph M; Ross, Hannah L; Laing, Emma M; Modlesky, Christopher M; Pollock, Norman K; Baile, Clifton A; Lewis, Richard D

    2015-04-01

    Assessment of physical activity in clinical bone studies is essential. Two bone-specific physical activity scoring methods, the Bone Loading History Questionnaire (BLHQ) and Bone-Specific Physical Activity Questionnaire (BPAQ), have shown correlations with bone density and geometry, but not architecture. The purpose of this study was to determine relationships between physical activity scoring methods and bone architecture in non-Hispanic white adolescent females (N = 24; 18-19 years of age). Bone loading scores (BLHQ [hip and spine] and past BPAQ) and energy expenditure (7-day physical activity recall) were determined from respective questionnaires. Estimates of trabecular and cortical bone architecture at the nondominant radius and tibia were assessed via magnetic resonance imaging. Total body and regional areal bone mineral density (aBMD), as well as total body fat mass and fat-free soft tissue (FFST) mass were assessed via dual energy X-ray absorptiometry. Pearson's correlations and partial correlations adjusting for height, total body fat mass, and FFST were performed. Hip BLHQ scores were correlated with midtibia cortical volume (r = .43; p = .03). Adjusted hip and spine BLHQ scores were correlated with all midtibia cortical measures (r = .50-0.58; p < .05) and distal radius apparent trabecular number (r = .46-0.53; p < .05). BPAQ scores were correlated with all midtibia cortical (r = .41-0.51; p < .05) and most aBMD (r = .47-0.53; p < .05) measures. Energy expenditure was inversely associated with femoral neck aBMD only after statistical adjustment (r = .49, p < .05). These data show that greater load-specific physical activity scores, but not energy expenditure, are indicative of greater midtibia cortical bone quality, thus supporting the utility of these instruments in musculoskeletal research.

  10. Phytochemical Composition, Antioxidant and Xanthine Oxidase Inhibitory Activities of <em>Amaranthus cruentusem> L. and <em>Amaranthus hybridusem> L. Extracts

    Directory of Open Access Journals (Sweden)

    Jeanne F. Millogo

    2012-06-01

    Full Text Available This paper describes a preliminary assessment of the nutraceutical value of <em>Amaranthus cruentus (A. cruentusem> and <em>Amaranthus hybridus (A. hybridusem>, two food plant species found in Burkina Faso. Hydroacetonic (HAE, methanolic (ME, and aqueous extracts (AE from the aerial parts were screened for <em>in vitroem> antioxidant and xanthine oxidase inhibitory activities. Phytochemical analyses revealed the presence of polyphenols, tannins, flavonoids, steroids, terpenoids, saponins and betalains. Hydroacetonic extracts have shown the most diversity for secondary metabolites. The TLC analyses of flavonoids from HAE extracts showed the presence of rutin and other unidentified compounds. The phenolic compound contents of the HAE, ME and AE extracts were determined using the Folin–Ciocalteu method and ranged from 7.55 to 10.18 mg Gallic acid equivalent GAE/100 mg. Tannins, flavonoids, and flavonols ranged from 2.83 to 10.17 mg tannic acid equivalent (TAE/100 mg, 0.37 to 7.06 mg quercetin equivalent (QE /100 mg, and 0.09 to 1.31 mg QE/100 mg, respectively. The betacyanin contents were 40.42 and 6.35 mg Amaranthin Equivalent/100 g aerial parts (dry weight in <em>A. cruentusem> and <em>A. hybridusem>, respectively. Free-radical scavenging activity expressed as IC50 (DPPH method and iron reducing power (FRAP method ranged from 56 to 423 µg/mL and from 2.26 to 2.56 mmol AAE/g, respectively. Xanthine oxidase inhibitory activities of extracts of <em>A. cruentus em>and <em>A. hybridusem> were 3.18% and 38.22%, respectively.<em> em>The> A. hybridusem> extract showed the best antioxidant and xanthine oxidase inhibition activities. The results indicated that the phytochemical contents of the two species justify their traditional uses as nutraceutical food plants.

  11. Chemical Composition and Biological Activities of the Essential Oils from <em>Duguetia lanceolataem> St. Hil. Barks

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    Maria A. C. Kaplan

    2012-09-01

    Full Text Available Essential oils of <em>Duguetia lanceolataem> barks, obtained at 2 (T2 and 4 h (T4, were identified by gas chromatography and gas chromatography/mass spectrometry. β-Elemene (12.7 and 14.9%, caryophyllene oxide (12.4 and 10.7% and β-selinene (8.4 and 10.4% were the most abundant components in T2 and T4, respectively. The essential oils inhibited the growth of <em>Staphylococcus aureusem>,> Streptococcus pyogenesem>, <em>Escherichia coliem> and <em>Candida albicansem>. The essential oils were cytotoxic against brine shrimp. The extraction time influenced the chemical composition and biological activities of essential oils obtained from the barks of <em>D. lanceolataem>.

  12. Evaluating Transcription Factor Activity Changes by Scoring Unexplained Target Genes in Expression Data

    Science.gov (United States)

    Berchtold, Evi; Csaba, Gergely; Zimmer, Ralf

    2016-01-01

    Several methods predict activity changes of transcription factors (TFs) from a given regulatory network and measured expression data. But available gene regulatory networks are incomplete and contain many condition-dependent regulations that are not relevant for the specific expression measurement. It is not known which combination of active TFs is needed to cause a change in the expression of a target gene. A method to systematically evaluate the inferred activity changes is missing. We present such an evaluation strategy that indicates for how many target genes the observed expression changes can be explained by a given set of active TFs. To overcome the problem that the exact combination of active TFs needed to activate a gene is typically not known, we assume a gene to be explained if there exists any combination for which the predicted active TFs can possibly explain the observed change of the gene. We introduce the i-score (inconsistency score), which quantifies how many genes could not be explained by the set of activity changes of TFs. We observe that, even for these minimal requirements, published methods yield many unexplained target genes, i.e. large i-scores. This holds for all methods and all expression datasets we evaluated. We provide new optimization methods to calculate the best possible (minimal) i-score given the network and measured expression data. The evaluation of this optimized i-score on a large data compendium yields many unexplained target genes for almost every case. This indicates that currently available regulatory networks are still far from being complete. Both the presented Act-SAT and Act-A* methods produce optimal sets of TF activity changes, which can be used to investigate the difficult interplay of expression and network data. A web server and a command line tool to calculate our i-score and to find the active TFs associated with the minimal i-score is available from https://services.bio.ifi.lmu.de/i-score. PMID:27723775

  13. Schizotypal perceptual aberrations of time: correlation between score, behavior and brain activity.

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    Shahar Arzy

    Full Text Available A fundamental trait of the human self is its continuum experience of space and time. Perceptual aberrations of this spatial and temporal continuity is a major characteristic of schizophrenia spectrum disturbances--including schizophrenia, schizotypal personality disorder and schizotypy. We have previously found the classical Perceptual Aberration Scale (PAS scores, related to body and space, to be positively correlated with both behavior and temporo-parietal activation in healthy participants performing a task involving self-projection in space. However, not much is known about the relationship between temporal perceptual aberration, behavior and brain activity. To this aim, we composed a temporal Perceptual Aberration Scale (tPAS similar to the traditional PAS. Testing on 170 participants suggested similar performance for PAS and tPAS. We then correlated tPAS and PAS scores to participants' performance and neural activity in a task of self-projection in time. tPAS scores correlated positively with reaction times across task conditions, as did PAS scores. Evoked potential mapping and electrical neuroimaging showed self-projection in time to recruit a network of brain regions at the left anterior temporal cortex, right temporo-parietal junction, and occipito-temporal cortex, and duration of activation in this network positively correlated with tPAS and PAS scores. These data demonstrate that schizotypal perceptual aberrations of both time and space, as reflected by tPAS and PAS scores, are positively correlated with performance and brain activation during self-projection in time in healthy individuals along the schizophrenia spectrum.

  14. Nursing Activities Score: an updated guideline for its application in the Intensive Care Unit

    Directory of Open Access Journals (Sweden)

    Katia Grillo Padilha

    2015-12-01

    Full Text Available ABSTRACT Objective To describe nursing workload in Intensive Care Units (ICU in different countries according to the scores obtained with Nursing Activities Score (NAS and to verify the agreement among countries on the NAS guideline interpretation. Method This cross-sectional study considered 1-day measure of NAS (November 2012 obtained from 758 patients in 19 ICUs of seven countries (Norway, the Netherlands, Spain, Poland, Egypt, Greece and Brazil. The Delphi technique was used in expertise meetings and consensus. Results The NAS score was 72.8% in average, ranging from 44.5% (Spain to 101.8% (Norway. The mean NAS score from Poland, Greece and Egypt was 83.0%, 64.6% and 57.1%, respectively. The NAS score was similar in Brazil (54.0% and in the Netherlands (51.0%. There were doubts in the understanding of five out 23 items of the NAS (21.7% which were discussed until researchers’ consensus. Conclusion NAS score were different in the seven countries. Future studies must verify if the fine standardization of the guideline can have a impact on differences in the NAS results.

  15. A cross-sectional study of the Birmingham Vasculitis Activity Score version 3 in systemic vasculitis

    NARCIS (Netherlands)

    Suppiah, Ravi; Mukhtyar, Chetan; Flossmann, Oliver; Alberici, Federico; Baslund, Bo; Batra, Rajbir; Brown, Denise; Holle, Julia; Hruskova, Zdenka; Jayne, David R. W.; Judge, Andrew; Little, Mark A.; Palmisano, Alessandra; Stegeman, Coen; Tesar, Vladimir; Vaglio, Augusto; Westman, Kerstin; Luqmani, Raashid

    2011-01-01

    Methods. A total of 238 patients with vasculitis from seven countries in Europe were evaluated at a single time point. Spearman's correlation coefficients were calculated between BVAS v. 3 scores, vasculitis activity index (VAI), physician's global assessment (PGA), the physician's treatment decisio

  16. Toward Development of a Fibromyalgia Responder Index and Disease Activity Score: OMERACT Module Update

    DEFF Research Database (Denmark)

    Mease, Philip J; Clauw, Daniel J; Christensen, Robin

    2011-01-01

    Following development of the core domain set for fibromyalgia (FM) in Outcome Measures in Rheumatology Clinical Trials (OMERACT) meetings 7 to 9, the FM working group has progressed toward the development of an FM responder index and a disease activity score based on these domains, utilizing...... outcome indices of these domains from archived randomized clinical trials in FM. Possible clinical domains that could be included in a responder index and disease activity score include pain, fatigue, sleep disturbance, cognitive dysfunction, mood disturbance, tenderness, stiffness, and functional...... spondylitis represents heuristic models for our work, but FM is challenging in that there is no clear algorithm of treatment that defines disease activity based on treatment decisions, nor are there objective markers that define thresholds of severity or response to treatment. The process of developing...

  17. Comparação dos escores dos protocolos QVV, IDV e PPAV em professores Comparison of V-RQOL, VHI and VAPP scores in teachers

    Directory of Open Access Journals (Sweden)

    Alessandra Sayuri Tutya

    2011-09-01

    Handicap Index and VAPP (Voice Activity and Participation Profile, and to analyze the correspondence of information obtained by these instruments. METHODS: Fourty six teachers with voice complaints that sought for speech-language pathology intervention and were diagnosed with behavioral dysphonia answered randomly the V-RQOL, VHI and VAPP questionnaires. RESULTS: Dysphonic teachers presented worse quality of life than the general dysphonic population on the V-RQOL. The VHI showed no significant handicap. On the VAPP, teachers had lower scores in the effects in social communication. The physical (VHI and physical functioning (V-RQOL domains were similar to each other. The VAPP provides information about aspects not contemplated by the other protocols; self-perception of the severity of dysphonia was correlated with all domains of the three protocols. The items with greatest impact on the V-RQOL were from the physical functioning domain, and, on the VHI, from the physical domain. On the VAPP, the two questions with greater occurrence were related to the effect of voice over emotion. Hence, for this population, it is suggested the use of the VAPP questionnaire, because it comprises aspects that the others don't; in addition, the V-RQOL should also be used, because it has fewer questions and more impact (total and emotional scores than the VHI. CONCLUSION: The protocols do not show the same information for dysphonic teachers. The physical functioning (V-RQOL and physical (VHI domains provide similar results, however social-emotional domain of the V-RQOL exhibited more evidently the impact of the voice disorder in dysphonic teachers than the VHI. The VAPP present information not contemplated by the other protocols.

  18. Development and First Validation of a Disease Activity Score for Gout

    Science.gov (United States)

    Carrara, Greta; Viroli, Cinzia; Cimmino, Marco A.; Taylor, William J.; Manara, Maria; Govoni, Marcello; Salaffi, Fausto; Punzi, Leonardo; Montecucco, Carlomaurizio; Matucci‐Cerinic, Marco; Minisola, Giovanni; Ariani, Alarico; Galossi, Alessandra; Lauriti, Ciro; Fracassi, Elena; Idolazzi, Luca; Bardelli, Marco; Selvi, Enrico; Tirri, Enrico; Furini, Federica; Inverardi, Flora; Calabrò, Andrea; Porta, Francesco; Bittelli, Raffaele; Venturino, Francesco; Capsoni, Franco; Prevete, Immacolata; Sebastiani, Giandomenico; Selmi, Carlo; Fabbriciani, Gianluigi; D'Avola, Giovanni; Botticella, Giulia; Serale, Francesca; Seminara, Giulia; D'Alessandro, Giuseppe; Santo, Leonardo; Longato, Lorena; Zaccara, Eleonora; Sinigaglia, Luigi; Atteritano, Marco; Broggini, Marco; Caprioli, Marta; Favero, Marta; Sallì, Salvatore; Scarati, Marco; Parisi, Simone; Malavolta, Nazzarena; Corvaglia, Stefania; Scarpato, Salvatore; Veneto, Vittorio

    2016-01-01

    Objective To develop a new composite disease activity score for gout and provide its first validation. Methods Disease activity has been defined as the ongoing presence of urate deposits that lead to acute arthritis and joint damage. Every measure for each Outcome Measures in Rheumatology core domain was considered. A 3‐step approach (factor analysis, linear discriminant analysis, and linear regression) was applied to derive the Gout Activity Score (GAS). Decision to change treatment or 6‐month flare count were used as the surrogate criteria of high disease activity. Baseline and 12‐month followup data of 446 patients included in the Kick‐Off of the Italian Network for Gout cohort were used. Construct‐ and criterion‐related validity were tested. External validation on an independent sample is reported. Results Factor analysis identified 5 factors: patient‐reported outcomes, joint examination, flares, tophi, and serum uric acid (sUA). Discriminant function analysis resulted in a correct classification of 79%. Linear regression analysis identified a first candidate GAS including 12‐month flare count, sUA, visual analog scale (VAS) of pain, VAS global activity assessment, swollen and tender joint counts, and a cumulative measure of tophi. Alternative scores were also developed. The developed GAS demonstrated a good correlation with functional disability (criterion validity) and discrimination between patient‐ and physician‐reported measures of active disease (construct validity). The results were reproduced in the external sample. Conclusion This study developed and validated a composite measure of disease activity in gout. Further testing is required to confirm its generalizability, responsiveness, and usefulness in assisting with clinical decisions. PMID:26815286

  19. Lack of physical activity in young children is related to higher composite risk factor score for cardiovascular disease

    DEFF Research Database (Denmark)

    Tanha, Tina; Wollmer, Per; Thorsson, Ola

    2011-01-01

    This study evaluates whether accelerometer-measured physical activity is related to higher composite risk factor scores for cardiovascular disease (CVD) in children.......This study evaluates whether accelerometer-measured physical activity is related to higher composite risk factor scores for cardiovascular disease (CVD) in children....

  20. Clinical performance of two visual scoring systems in detecting and assessing activity status of occlusal caries in primary teeth

    DEFF Research Database (Denmark)

    Braga, M M; Ekstrand, K R; Martignon, S

    2010-01-01

    This study aimed to compare the clinical performance of two sets of visual scoring criteria for detecting caries severity and assessing caries activity status in occlusal surfaces. Two visual scoring systems--the Nyvad criteria (NY) and the ICDAS-II including an adjunct system for lesion activity...

  1. A cross-sectional study of the Birmingham Vasculitis Activity Score version 3 in systemic vasculitis

    DEFF Research Database (Denmark)

    Suppiah, Ravi; Mukhtyar, Chetan; Flossmann, Oliver;

    2011-01-01

    Objective. Assessment of disease activity in vasculitis can be achieved using the BVAS, a clinical checklist of relevant symptoms, signs and features of active disease. The aim of this study was to revalidate the BVAS version 3 (BVAS v. 3) in a cohort of patients with systemic vasculitis. Methods....... A total of 238 patients with vasculitis from seven countries in Europe were evaluated at a single time point. Spearman's correlation coefficients were calculated between BVAS v. 3 scores, vasculitis activity index (VAI), physician's global assessment (PGA), the physician's treatment decision, CRP...... and the vasculitis damage index (VDI) to demonstrate that the BVAS v. 3 measures disease activity. Results. WG (63%), Churg-Strauss syndrome (9%) and microscopic polyangiitis (9%) were the most common diagnoses. The BVAS v. 3 showed convergent validity with the VAI [¿¿=¿0.82 (95% CI 0.77, 0.85)], PGA [¿¿=¿0.85 (95...

  2. The Reliability of Disease Activity Score in 28 Joints-C-Reactive Protein Might Be Overestimated in a Subgroup of Rheumatoid Arthritis Patients, When the Score Is Solely Based on Subjective Parameters

    DEFF Research Database (Denmark)

    Jensen Hansen, Inger Marie; Asmussen Andreasen, Rikke; Van Bui Hansen, Mark Nam;

    2016-01-01

    BACKGROUND: Disease Activity Score in 28 Joints (DAS28) is a scoring system to evaluate disease activity and treatment response in rheumatoid arthritis (RA). A DAS28 score of greater than 3.2 is a well-described limit for treatment intensification; however, the reliability of DAS28 might be overe...

  3. Translating DPYD genotype into DPD phenotype: using the DPYD gene activity score.

    Science.gov (United States)

    Henricks, Linda M; Lunenburg, Carin A T C; Meulendijks, Didier; Gelderblom, Hans; Cats, Annemieke; Swen, Jesse J; Schellens, Jan H M; Guchelaar, Henk-Jan

    2015-01-01

    The dihydropyrimidine dehydrogenase enzyme (DPD, encoded by the gene DPYD) plays a key role in the metabolism of fluoropyrimidines. DPD deficiency occurs in 4-5% of the population and is associated with severe fluoropyrimidine-related toxicity. Several SNPs in DPYD have been described that lead to absent or reduced enzyme activity, including DPYD*2A, DPYD*13, c.2846A>T and c.1236G>A/haplotype B3. Since these SNPs differ in their effect on DPD enzyme activity, a differentiated dose adaption is recommended. We propose the gene activity score for translating DPYD genotype into phenotype, accounting for differences in functionality of SNPs. This method can be used to standardize individualized fluoropyrimidine dose adjustments, resulting in optimal safety and effectiveness.

  4. Avaliação do EuroSCORE como preditor de mortalidade em cirurgia cardíaca valvar no Instituto do Coração de Pernambuco Assesment of the EuroSCORE as a predictor for mortality in valve cardiac surgery at the Heart Institute of Pernambuco

    Directory of Open Access Journals (Sweden)

    Isaac Newton Guimarães Andrade

    2010-03-01

    Full Text Available OBJETIVO: Avaliar a aplicabilidade do Sistema Europeu de Risco em Operações Cardíacas (EuroSCORE em pacientes submetidos à cirurgia valvar no Instituto do Coração de Pernambuco. MÉTODOS: Foram incluídos no estudo 840 pacientes operados entre 2001 e 2009. Os prontuários desses doentes continham todas as informações que permitiram calcular o EuroSCORE. O desfecho de interesse foi óbito na internação. Com o objetivo de avaliar a aplicabilidade do EuroSCORE, foi usado o teste não paramétrico de Mann-Whitney. A calibração do modelo foi medida pela comparação da mortalidade observada com a esperada, usando-se o teste de bondade de ajuste de Hosmer-Lemershow. A acurácia do modelo foi avaliada pela curva ROC (receiver operating characteristic curve. RESULTADOS: A comparação entre a mortalidade prevista e a observada, por meio do teste de Hosmer-Lemershow, evidenciou boa capacidade preditiva (P=0,767, assim como quando comparada para cada valor do EuroSCORE Aditivo (P=0,455. Obteve-se uma área sob a curva de ROC de 0,731 (IC95% 0,660 - 0,793, com valor de P6 incluiu 131 pacientes, com mortalidade foi 20,6%. A análise de regressão logística permitiu identificar os seguintes fatores de risco para o óbito: idade acima de 60 anos, sexo feminino, operação prévia, endocardite ativa, cirurgia associada da aorta torácica e arteriopatia extracardíaca. CONCLUSÕES: O EuroSCORE, um método simples e objetivo, revelou-se um preditor satisfatório de mortalidade operatória e, por ele, foram identificados fatores de risco para o óbito em pacientes submetidos à cirurgia valvar no Instituto do Coração de Pernambuco.OBJECTIVE: To assess the applicability of the European Rysk System in Cardiac Operations (EuroSCORE in patients undergoing cardiac valve surgery at the Heart Institute of Pernambuco. METHOD: 840 patients operated on between 2001 and 2009, who medical records contained all the informations to calculate the EuroSCORE were

  5. Alimentary Habits, Physical Activity, and Framingham Global Risk Score in Metabolic Syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Soares, Thays Soliman; Piovesan, Carla Haas; Gustavo, Andréia da Silva; Macagnan, Fabrício Edler; Bodanese, Luiz Carlos; Feoli, Ana Maria Pandolfo, E-mail: anamariafeoli@hotmail.com [Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS (Brazil)

    2014-04-15

    Metabolic syndrome is a complex disorder represented by a set of cardiovascular risk factors. A healthy lifestyle is strongly related to improve Quality of Life and interfere positively in the control of risk factors presented in this condition. To evaluate the effect of a program of lifestyle modification on the Framingham General Cardiovascular Risk Profile in subjects diagnosed with metabolic syndrome. A sub-analysis study of a randomized clinical trial controlled blind that lasted three months. Participants were randomized into four groups: dietary intervention + placebo (DIP), dietary intervention + supplementation of omega 3 (fish oil 3 g/day) (DIS3), dietary intervention + placebo + physical activity (DIPE) and dietary intervention + physical activity + supplementation of omega 3 (DIS3PE). The general cardiovascular risk profile of each individual was calculated before and after the intervention. The study included 70 subjects. Evaluating the score between the pre and post intervention yielded a significant value (p < 0.001). We obtained a reduction for intermediate risk in 25.7% of subjects. After intervention, there was a significant reduction (p < 0.01) on cardiovascular age, this being more significant in groups DIP (5.2%) and DIPE (5.3%). Proposed interventions produced beneficial effects for reducing cardiovascular risk score. This study emphasizes the importance of lifestyle modification in the prevention and treatment of cardiovascular diseases.

  6. Is there a preferred method for scoring activity of the spine by magnetic resonance imaging in ankylosing spondylitis?

    DEFF Research Database (Denmark)

    van der Heijde, Désirée; Landewé, Robert; Hermann, Kay-Geert

    2007-01-01

    This report summarizes the discussion during a module update at OMERACT 8 on scoring methods for activity in the spine on magnetic resonance imaging. The conclusion was that the 3 available scoring methods are all very good with respect to discrimination and feasibility: the Ankylosing Spondyliti...

  7. Scoring inflammatory activity of the spine by magnetic resonance imaging in ankylosing spondylitis: a multireader experiment

    DEFF Research Database (Denmark)

    Lukas, Cédric; Braun, Jürgen; van der Heijde, Désirée

    2007-01-01

    ) assessed by Z-scores was good and comparable among methods. CONCLUSION: This experiment demonstrates the feasibility of multiple-reader MRI scoring exercises for method comparison, provides evidence for the feasibility, reliability, sensitivity to change, and discriminatory capacity of all 3 tested scoring...... by the reader as the most abnormal, with additional scores for "depth" and "intensity." Both the order of the methods used by each reader and the timepoints (before/after treatment) were randomized. Feasibility of each scoring system was evaluated by measuring the mean time needed to score each set of MRI...

  8. Evaluation of Antioxidant and Immunity-Enhancing Activities of <em>Sargassum pallidumem> Aqueous Extract in Gastric Cancer Rats

    Directory of Open Access Journals (Sweden)

    Shen-Kang Zhou

    2012-07-01

    Full Text Available The effect of <em>Sargassum pallidumem> (brown seaweed aqueous extract on the immunity function and antioxidant activities in was studied gastric cancer rats. Treatment with <em>Sargassum pallidumem> aqueous extract at oral doses 400, 600 or 800 mg/kg body weight was found to provide a dose-dependent protection against <em>Nem>-methyl-N′-nitro-N>-nitrosoguanidine (MNNG-induced immunity damage and oxidative injury by enhancing serum interleukin-2 (IL-2, interleukin-4 (IL-4, interleukin-10 (IL-10 levels, decreasing interleukin-6 (IL-6, interleukin-1β (IL-1β, tumor necrosis factor-alpha (TNF-α levels, preserving normal antioxidant enzymes activities, and by inhibiting lipid peroxidation in gastric mucosa. It can be concluded that <em>Sargassum pallidumem> aqueous extract may enhance the immunity and antioxidant activities in gastric cancer rats.

  9. A multi-biomarker disease activity score for monitoring rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    Hirata S

    2015-10-01

    physicians with a convenient measurement tool to monitor patients in a clinical setting and support rapid treatment adjustment and tighter disease control. This article examines peer-reviewed publications cited in PubMed that describe the multi-biomarker disease activity score, its development and validation, and its applications as an objective disease assessment tool in patients with RA. Keywords: algorithm, multi-biomarker disease activity score, disease activity, rheumatoid arthritis, Vectra DA

  10. Nursing activities score (NAS): a proposal for practical application in intensive care units.

    Science.gov (United States)

    Gonçalves, Leilane Andrade; Padilha, Katia Grillo; Cardoso Sousa, Regina M

    2007-12-01

    For over 30 years in an attempt to demonstrate the cost-benefit ratio of the intensive care unit (ICU) a variety of tools have been developed to measure not only the severity of illness of the patient but also to capture the true cost of nursing workload. In this context, the nursing activities score (NAS) was developed as a result of modifications to the therapeutic interventions scoring system-28 (TISS-28). The NAS is a tool to measure nursing workload ICU and it has been shown to be twice as effective in measuring how nurses spend their time caring for critically ill patients than the TISS-28. This paper discuss the introduction of the NAS into everyday use in an intensive care unit in Brazil and highlights the challenges of standardisation of operational definitions, training requirements and accurate completion of the documentation when using such a tool. The rationale and steps undertaken to achieve this are outlined and the benefits of such a process are highlighted.

  11. Further optimization of the reliability of the 28-joint disease activity score in patients with early rheumatoid arthritis

    OpenAIRE

    Liseth Siemons; ten Klooster, Peter M.; Vonkeman, Harald E.; van de laar, Mart A. F. J.; Glas, Cees A. W.

    2014-01-01

    BACKGROUND: The 28-joint Disease Activity Score (DAS28) combines scores on a 28-tender and swollen joint count (TJC28 and SJC28), a patient-reported measure for general health (GH), and an inflammatory marker (either the erythrocyte sedimentation rate [ESR] or the C-reactive protein [CRP]) into a composite measure of disease activity in rheumatoid arthritis (RA). This study examined the reliability of the DAS28 in patients with early RA using principles from generalizability theory and evalua...

  12. Scoring inflammatory activity of the spine by magnetic resonance imaging in ankylosing spondylitis: a multireader experiment

    DEFF Research Database (Denmark)

    Lukas, C; Braun, J; van der Heijde, D;

    2007-01-01

    ) assessed by Z-scores was good and comparable among methods. CONCLUSION: This experiment demonstrates the feasibility of multiple-reader MRI scoring exercises for method comparison, provides evidence for the feasibility, reliability, sensitivity to change, and discriminatory capacity of all 3 tested scoring...

  13. Interpreting the multi-biomarker disease activity score in the context of tocilizumab treatment for patients with rheumatoid arthritis.

    Science.gov (United States)

    Reiss, William G; Devenport, Jenny N; Low, Jason M; Wu, George; Sasso, Eric H

    2016-02-01

    The multi-biomarker disease activity (MBDA) score measures 12 proteins involved in the pathophysiology of rheumatoid arthritis (RA) to assess disease activity (DA). Previous studies demonstrated correlations between MBDA and clinical DA scores with some RA therapies. In this analysis, the relationship between DA and MBDA scores and changes in MBDA component biomarkers were evaluated in tocilizumab (TCZ)-treated patients. Patients from the ACT-RAY study were included in this analysis if they had DA measures and serum collected at pre-specified time points with sufficient serum for MBDA testing at ≥1 visit. Descriptive statistics, associations between outcomes, and percentage agreement between DA categories were calculated. Seventy-eight patients were included and were similar to the ACT-RAY population. Correlations between MBDA score and DAS28-CRP were ρ = 0.50 at baseline and ρ = 0.26 at week 24. Agreement between low/moderate/high categories of MBDA score and DAS28-CRP was observed for 77.1 % of patients at baseline and 23.7 % at week 24. Mean changes from baseline to weeks 4, 12, and 24 were proportionately smaller for MBDA score than DAS28-CRP. Unlike some other MBDA biomarkers, interleukin-6 (IL-6) concentrations increased in most patients during TCZ treatment. Correlations and agreement between MBDA and DAS28-CRP or CDAI scores were lower at week 24 versus baseline. The proportionately smaller magnitude of response observed for MBDA score versus DAS28-CRP may be due to the influence of the increase in IL-6 concentrations on MBDA score. Thus, MBDA scores obtained during TCZ treatment should be interpreted cautiously and in the context of available clinical information.

  14. Disease activity in Graves' ophthalmopathy: diagnosis with orbital MR imaging and correlation with clinical score.

    Science.gov (United States)

    Tortora, Fabio; Cirillo, Mario; Ferrara, Marco; Belfiore, Maria Paola; Carella, Carlo; Caranci, Ferdinando; Cirillo, Sossio

    2013-10-01

    In Graves' ophthalmopathy (GO) it is important to distinguish acute inflammation at an early stage, responsive to immunosuppressive treatment, from inactive fibrotic end stage disease, unresponsive to the same treatment. The purpose of this study was to identify the most relevant signal intensities on orbital MR imaging with contrast administration both to classify patients according to their clinical activity score (defined by a cut-off value of 3) and to make a prediction of patient's CAS. Such threshold was considered as widely used in literature. Sixteen consecutive patients with a diagnosis of GO in different phases of thyroid disease based on clinical and orbital MR imaging signs, and six normal volunteers were examined. Orbital MR imaging was performed on a 1.5 Tesla MR Unit. MR scans were assessed by an experienced neuroradiologist, blinded to the clinical examinations. We found a statistical correlation between CAS and both STIR and contrast enhanced T1-weighted sequences. There was also a statistically significant correlation between STIR and contrast-enhanced T1 images disclosing the possibility of avoiding the injection of contrast medium. Our study proved that signal intensity values on STIR sequence increase in the inflammatory oedematous phase of disease. We confirmed the correlation between signal intensities on this sequence and CAS, showing an increase in signal intensity proportional to the CAS value. So we validated MRI use to establish the activity phase of disease more sensitively than CAS alone.

  15. Disease Activity in Graves' Ophthalmopathy: Diagnosis with Orbital MR Imaging and Correlation with Clinical Score

    Science.gov (United States)

    Tortora, Fabio; Cirillo, Mario; Ferrara, Marco; Belfiore, Maria Paola; Carella, Carlo; Caranci, Ferdinando; Cirillo, Sossio

    2013-01-01

    Summary In Graves' ophthalmopathy (GO) it is important to distinguish acute inflammation at an early stage, responsive to immunosuppressive treatment, from inactive fibrotic end stage disease, unresponsive to the same treatment. The purpose of this study was to identify the most relevant signal intensities on orbital MR imaging with contrast administration both to classify patients according to their clinical activity score (defined by a cut-off value of 3) and to make a prediction of patient's CAS. Such threshold was considered as widely used in literature. Sixteen consecutive patients with a diagnosis of GO in different phases of thyroid disease based on clinical and orbital MR imaging signs, and six normal volunteers were examined. Orbital MR imaging was performed on a 1.5 Tesla MR Unit. MR scans were assessed by an experienced neuroradiologist, blinded to the clinical examinations. We found a statistical correlation between CAS and both STIR and contrast enhanced T1-weighted sequences. There was also a statistically significant correlation between STIR and contrast-enhanced T1 images disclosing the possibility of avoiding the injection of contrast medium. Our study proved that signal intensity values on STIR sequence increase in the inflammatory oedematous phase of disease. We confirmed the correlation between signal intensities on this sequence and CAS, showing an increase in signal intensity proportional to the CAS value. So we validated MRI use to establish the activity phase of disease more sensitively than CAS alone. PMID:24199816

  16. Comparison of contemporary risk scores for predicting outcomes after surgery for active infective endocarditis.

    Science.gov (United States)

    Wang, Tom Kai Ming; Oh, Timothy; Voss, Jamie; Gamble, Greg; Kang, Nicholas; Pemberton, James

    2015-03-01

    Decision making regarding surgery for acute bacterial endocarditis is complex given its heterogeneity and often fatal course. Few studies have investigated the utility of operative risk scores in this setting. Endocarditis-specific scores have recently been developed. We assessed the prognostic utility of contemporary risk scores for mortality and morbidity after endocarditis surgery. Additive and logistic EuroSCORE I, EuroSCORE II, additive Society of Thoracic Surgeon's (STS) Endocarditis Score and additive De Feo-Cotrufo Score were retrospectively calculated for patients undergoing surgery for endocarditis during 2005-2011. Pre-specified primary outcomes were operative mortality, composite morbidity and mortality during follow-up. A total of 146 patients were included with an operative mortality of 6.8 % followed for 4.1 ± 2.4 years. Mean scores were additive EuroSCORE I: 8.0 ± 2.5, logistic EuroSCORE I: 13.2 ± 10.1 %, EuroSCORE II: 9.1 % ± 9.4 %, STS Score: 32.2 ± 13.5 and De Feo-Cotrufo Score: 14.6 ± 9.2. Corresponding areas under curve (AUC) for operative mortality 0.653, 0.645, 0.656, 0.699 and 0.744; for composite morbidity were 0.623, 0.625, 0.720, 0.714 and 0.774; and long-term mortality 0.588, 0.579, 0.686, 0.735 and 0.751. The best tool for post-operative stroke was EuroSCORE II: AUC 0.837; for ventilation >24 h and return to theatre the De Feo-Cotrufo Scores were: AUC 0.821 and 0.712. Pre-operative inotrope or intra-aortic balloon pump treatment, previous coronary bypass grafting and dialysis were independent predictors of operative and long-term mortality. In conclusion, risk models developed specifically from endocarditis surgeries and incorporating endocarditis variables have improved prognostic ability of outcomes, and can play an important role in the decision making towards surgery for endocarditis.

  17. Surface-active proteins from <em>Fusarium> spp. and their role in gushing in carbonated beverages<em>>

    OpenAIRE

    Lutterschmid, Georg

    2011-01-01

    Gushing is the spontaneous over-foaming of bottled carbonated beverages, particularly of beer. Due to its negative economical and image-damaging consequences it is of great interest for the beverage industry. To clarify the molecular causes of malt-related gushing, five surface-active proteins from filamentous fungi and from barley were heterologously expressed in Pichia pastoris. The proteins were isolated and their gushing-inducing activity was determined. The protein FcHyd5p was identified...

  18. Does body mass index (BMI) influence the Ankylosing Spondylitis Disease Activity Score in axial spondyloarthritis?

    Science.gov (United States)

    Rubio Vargas, Roxana; van den Berg, Rosaline; van Lunteren, Miranda; Ez-Zaitouni, Zineb; Bakker, Pauline A C; Dagfinrud, Hanne; Ramonda, Roberta; Landewé, Robert; Molenaar, Esmeralda; van Gaalen, Floris A; van der Heijde, Désirée

    2016-01-01

    Objective Obesity is associated with elevated C reactive protein (CRP) levels. The Ankylosing Spondylitis Disease Activity Score (ASDAS) combines patient-reported outcomes (PROs) and CRP. We evaluated the effect of body mass index (BMI) on CRP and on ASDAS, and studied if ASDAS can be used in obese axial spondyloarthritis (axSpA) patients to assess disease activity. Methods Baseline data of patients with chronic back pain of short duration included in the SPondyloArthritis Caught Early (SPACE) cohort were used. Collected data included BMI and ASDAS. Patients were classified according to the ASAS axSpA classification criteria and BMI (overweight ≥25 and obese ≥30). Correlation and linear regression analyses were performed to assess the relation between BMI and ASDAS. Linear regression models were performed to assess if age or gender were effect modifiers in the relation between BMI and CRP, and between BMI and ASDAS. Results In total, 428 patients were analysed (n=168 axSpA; n=260 no-axSpA). The mean age was 31.1 years, 36.9% were male, 26.4% were overweight and 13.3% obese, median CRP was 3 mg/L and the mean ASDAS was 2.6. Gender was the only factor modifying the relationship between BMI and CRP as BMI had an influence on CRP only in females (β=0.35; p<0.001). Correlations between BMI and CRP or PROs were generally weak, and only significant for CRP in female patients. BMI was not related to ASDAS in axSpA patients. Conclusions ASDAS is not affected by BMI in axSpA patients. Therefore, based on our data it is not necessary to take BMI in consideration when assessing disease activity using ASDAS in axSpA patients. PMID:27403336

  19. Terpene Glycosides from the Roots of <em>Sanguisorba officinalisem> L. and Their Hemostatic Activities

    Directory of Open Access Journals (Sweden)

    Wei Sun

    2012-06-01

    Full Text Available Guided by a hemostasis bioassay, seven terpene glycosides were isolated from the roots of <em>Sanguisorba officinalisem> L. by silica gel column chromatography and preparative HPLC. On the grounds of chemical and spectroscopic methods, their structures were identified as citronellol-1-<em>O>-α-l-arabinofuranosyl-(1→6-β-d-glucopyranoside (1, geraniol-1-<em>O>-α-l-arabinofuranosyl-(1→6-β-d-glucopyranoside (2, geraniol-1-<em>O>-α-l-arabinopyranosyl-(1→6-β-d-glucopyranoside (3, 3β-[(α-l-arabinopyranosyloxy]-19α-hydroxyolean-12-en-28-oic acid 28-β-d-glucopyranoside (4, 3β-[(α-l-arabinopyranosyl-oxy]-19α-hydroxyurs-12-en-28-oic acid 28-β-d-glucopyranoside (ziyu-glycoside I, 5, 3β,19α-hydroxyolean-12-en-28-oic acid 28-β-d-glucopyranoside (6 and 3β,19α-di-hydroxyurs-12-en-28-oic acid 28-β-d-glucopyranoside (7. Compound 1 is a new mono-terpene glycoside and compounds 2, 3 and 5 were isolated from the <em>Sanguisorba> genus for the first time. Compounds 17 were assayed for their hemostatic activities with a Goat Anti-Human α2-plasmin inhibitor ELISA kit, and ziyu-glycoside I (5 showed the strongest hemostatic activity among the seven terpene glycosides. This is the first report that ziyu-glycoside Ι has strong hemostatic activity.

  20. Hubungan antara Kadar Interleukin-6 (IL-6) dengan Disease Activity Score-28 (DAS28) pada Artritis Reumatoid

    OpenAIRE

    Ariestine, Dina Aprillia

    2012-01-01

    Background and Aim: Rheumatoid arthritis is a chronic inflammation disorder which various cytokines have important roles in inflammatory process and joint destruction. One of these is interleukin-6 (IL-6), abundantly expressed in the serum and synovial fibroblasts of patients with rheumatoid arthritis and its level correlates with the disease activity and joint destruction. Disease Activity Score-28 (DAS28) has been the most commonly used to measure the disease activity. This study aimed to d...

  1. Phenolics and Flavonoids Compounds, Phenylanine Ammonia Lyase and Antioxidant Activity Responses to Elevated CO2 in <em>Labisia pumilaem> (Myrisinaceae

    Directory of Open Access Journals (Sweden)

    Hawa Z.E. Jaafar

    2012-05-01

    Full Text Available A split plot 3 × 3 experiment was designed to examine the impact of three concentrations of CO2 (400, 800 and 1,200 µmol·mol−1 on the phenolic and flavonoid compound profiles, phenylalanine ammonia lyase (PAL and antioxidant activity in three varieties of <em>Labisia pumilaem> Benth. (var. <em>alata,> pumila em>and> lanceolataem> after 15 weeks of exposure. HPLC analysis revealed a strong influence of increased CO2 concentration on the modification of phenolic and flavonoid profiles, whose intensity depended on the interaction between CO2 levels and <em>L. pumilaem> varieties. Gallic acid and quercetin were the most abundant phenolics and flavonoids commonly present in all the varieties. With elevated CO2 (1,200 µmol·mol−1 exposure, gallic acid increased tremendously, especially in var. <em>alata> and <em>pumila em>(101–111%, whilst a large quercetin increase was noted in var. <em>lanceolata> (260%, followed closely by <em>alata> (201%. Kaempferol, although detected under ambient CO2 conditions, was undetected in all varieties after exposure. Instead, caffeic acid was enhanced tremendously in var. <em>alata> (338~1,100% and <em>pumila em>(298~433%. Meanwhile, pyragallol and rutin were only seen in var. <em>alata> (810 µg·g−1 DW and <em>pumila> (25 µg·g−1 DW, respectively, under ambient conditions; but the former compound went undetected in all varieties while rutin continued to increase by 262% after CO2 enrichment. Interestingly, naringenin that was present in all varieties under ambient conditions went undetected under enrichment, except for var. <em>pumila em>where it was enhanced by 1,100%. PAL activity, DPPH and FRAP also increased with increasing CO2 levels implying the possible improvement of health-promoting quality of Malaysian <em>L. pumilaem

  2. Activity of Spray-dried Microparticles Containing Pomegranate Peel Extract against <em>Candida albicansem>

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    Benedito Prado Dias Filho

    2012-08-01

    Full Text Available Pomegranate has attracted interest from researchers because of its chemical composition and biological properties. It possesses strong antioxidant activity, with potential health benefits, and also antimicrobial properties. The aim of this study was to produce microparticles containing pomegranate extract by the spray-drying technique, utilizing alginate or chitosan as encapsulating agents. Characterization and antifungal assays were carried out. Production yields were about 40% for alginate microparticles and 41% for chitosan. Mean diameters were 2.45 µm and 2.80 µm, and encapsulation efficiencies were 81.9% and 74.7% for alginate and chitosan microparticles, respectively. The spray-drying process preserved the antifungal activity against <em>Candida albicansem>. These results could be useful for developing dosage forms for treating candidiasis, and should be further investigated in <em>in vivoem> models.

  3. Escore de Framingham em motoristas de transportes coletivos urbanos de Teresina, Piauí Framingham score for public transportation drivers in the dity of Teresina, Piauí

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    Maurício Batista Paes Landim

    2006-09-01

    Full Text Available OBJETIVO: Estimar o risco absoluto de contração de doença arterial coronariana, nos próximos 10 anos, em motoristas de transportes coletivos urbanos de Teresina, Piauí, segundo o escore de risco de Framingham. MÉTODOS: Foi realizado um estudo observacional, descritivo, transversal, aplicando-se o escore de Framingham, em 107 motoristas de transportes coletivos urbanos de Teresina, Piauí, para avaliação do grau de risco e sua associação com as variáveis previstas no mesmo, que foram: idade, colesterol total, colesterol HDL, pressão arterial sistólica, pressão arterial diastólica, presença de diabete melito e tabagismo. O teste de significância usado foi o c². Utilizou-se a razão de prevalência como medida de associação. RESULTADOS: O risco médio foi de 5%, com a maior parte situando-se na categoria de baixo risco (85,05%. As médias obtidas foram: 42 anos para a idade, colesterol total 200 mg%, colesterol HDL 49 mg%, pressão arterial sistólica 130 mmHg e pressão arterial diastólica 85 mmHg. As associações diabete melito, tabagismo e colesterol HDL, com o risco, não foram estatisticamente significantes, diferente do ocorrido com as outras variáveis, que tiveram grande influência no risco obtido. CONCLUSÃO: O risco absoluto médio estimado para os próximos 10 anos de doença arterial coronariana, em motoristas de transportes coletivos urbanos de Teresina, calculado pelo escore de Framingham, apresentou-se baixo. Uma parte considerável dos participantes da pesquisa (85,05% situou-se na categoria de baixo risco, ou seja, igual ou inferior a 10%.OBJECTIVE: To estimate the absolute risk of the public transportation drivers in the city of Teresina, Piauí, to develop coronary heart disease over the course of ten years based on the Framingham risk score. METHODS: An observational, descriptive, cross-sectional study using the Framingham score was conducted with 107 public transportation drivers in the city of Teresina

  4. Chemical Composition and Biological Activity of Extracts from<em> Salvia bicolorem> Desf. Growing in Egypt

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    Taghreed A. Ibrahim

    2012-09-01

    Full Text Available A petroleum ether extract (PEE and a methanolic extract (ME of aerial parts of <em>Salvia bicolor em>Desf were prepared, and their chemical compositions and antioxidant, anti-inflammatory, analgesic and antimicrobial activities were evaluated. GC/MS analysis of the PEE revealed the presence of 20 compounds in the unsaponifiable matter, among which β-sitosterol and β-amyrin (constituting 24.75% and 15.62%, respectively were the main constituents, and 21 fatty acids, with linolenic acid and erucic acid being the main fatty acid constituents (21.65% and 16.65%, respectively. HPLC/MS analysis of the methanol extract for individual phenolics revealed the presence of 14 phenolic acids; protocatchuic acid was predominant (75.22 mg/g dry sample, followed by <em>p>-coumaric, gallic and synergic acids (70.27, 68.26 and 54.38 mg/g dry weight, respectively. HPLC/MS analysis of flavonoid contents revealed the presence of five flavonoid compounds, among which luteolin 7-<em>O>-glucoside and apigenin were the major constituents (120.25 mg/100g dry sample and 88.48 mg/100g dry sample, respectively. The antioxidant activities of both extracts were evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH assay, and the total antioxidant capacity was determined in terms of GAE (gallic acid equivalents. Anti-inflammatory and analgesic activities were evaluated using the rat paw edema and hot plate testing methods, respectively. The antimicrobial activities of both the PEE and ME were examined by means of the disk-diffusion method. The <em>Salvia bicolorem> PEE and ME exhibited significant antioxidant, anti-inflammatory, and analgesic properties, in addition to antimicrobial effects against the selected microorganisms.

  5. Psychometric Properties of the Scores on the Behavioral Inhibition and Activation Scales in a Sample of Norwegian Children

    Science.gov (United States)

    Bjornebekk, Gunnar

    2009-01-01

    The primary aim of this study was to examine the psychometric properties of the scores on a version for children of the Carver and White Behavioral Inhibition and Activation scales (the BIS-BAS scales). This involved administering the BIS-BAS scales, the Positive and Negative Affect Schedule, the Junior Eysenck Personality Questionnaire…

  6. Serum interleukin-18 and interleukin-10 levels in systemic lupus erythematosus: correlation with SLEDAI score and disease activity parameters

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    Sahar Abou El-Fetouh

    2014-01-01

    Conclusion The circulating IL-18 and IL-10 concentrations were significantly elevated in SLE patients and correlated with the SLEDAI score. The study emphasized that there exists an upregulated proinflammatory as well as anti-inflammatory responses in patients with active SLE; however, the anti-inflammatory response is not enough to suppress the active disease. Identifying the exact contribution of the currently studied cytokines might provide future insights for targeted therapeutic strategies in SLE.

  7. Amplitude-integrated electroencephalographic activity is suppressed in preterm infants with high scores on illness severity

    NARCIS (Netherlands)

    ter Horst, Hendrik J.; Jongbloed-Pereboom, Marjolein; van Eykern, Leo A.; Bos, Arend F.

    2011-01-01

    Background: The neonatal acute physiology score. SNAP-II, reflects the severity of illness in newborns. In term newborns, amplitude integrated EEG (aEEG), is depressed following asphyxia. In preterm infants aEEG is discontinuous, and therefore more difficult to assess compared to term infants. Aims:

  8. CORRELATION OF PEMPHIGUS VULGARIS ANTIBODY TITERS BY INDIRECT IMMUNOFLUORESCENCE WITH ACTIVITY OF DISEASE BASED ON PEMPHIGUS AREA AND ACTIVITY SCORE (PAAS

    Directory of Open Access Journals (Sweden)

    H. Mortazavi

    2008-06-01

    Full Text Available Indirect immunofluorescence (IIF has been used to identify and measure autoantibody levels in pemphigus vulgaris but data about relationship between clinical severity of disease and antibody titers by IIF have been conflicting. We conducted this cross-sectional study to correlate the severity of oral and/or cutaneous involvement in patients with pemphigus vulgaris based on Pemphigus Area and Activity Score with IIF titers. Sixty-one new pemphigus vulgaris patients were included in this study. Human prepuce was used as substrate for IIF and assessment of disease severity was based on Pemphigus Area and Activity Score. The mean±SD age was 44.04±30.46 years, with a range of 18 to 79 years. IIF was positive in 56 (91.8% patients. There was a significant relationship between total disease score and IIF titers ((P<0.001. Also a significant relationship was found between skin score (P=0.04 and mucosal score (P=0.04 with IIF titers. Our results show that there is a significant relationship between disease activity based on Pemphigus Area and Activity Score and antibody titers by IIF. Further studies are recommended to determine the usefulness of this technique for monitoring disease.

  9. The effects of activating prior topic and metacognitive knowledge on text comprehension scores

    NARCIS (Netherlands)

    Kostons, Danny; van der Werf, Margaretha

    2015-01-01

    Background Research on prior knowledge activation has consistently shown that activating learners' prior knowledge has beneficial effects on learning. If learners activate their prior knowledge, this activated knowledge serves as a framework for establishing relationships between the knowledge they

  10. Only the good... get pirated: game piracy activity vs. metacritic score

    DEFF Research Database (Denmark)

    Drachen, Anders; Bauer, Kevin; Veitch, Robert W. D.

    2011-01-01

    the substantial interest in game piracy, there is very little objective information available about its magnitude or its distribution across game titles and game genres. This paper presents a large-scale analysis of the illegal distribution of digital game titles, which was conducted by monitoring the Bit...... encompass 5.27 million aggregated unique peers alone. In addition to genre, review scores were found to be positively correlated with the logarithm of the number of unique peers per game (p

  11. Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants

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    Terrence M. Vance

    2015-01-01

    Full Text Available Background. Prostate cancer is the most common noncutaneous cancer and second leading cause of cancer-related mortality in men in the US. Growing evidence suggests that oxidative stress is involved in prostate cancer. Methods. In this study, thioredoxin 1 (Trx 1, an enzyme and subcellular indicator of redox status, was measured in prostate biopsy tissue from 55 men from the North Carolina-Louisiana Prostate Cancer Project. A pathologist blindly scored levels of Trx 1. The association between Trx 1 and the Gleason score, erythrocyte antioxidant enzyme activity, and dietary antioxidant intake was determined using Fisher’s exact test. Results. Trx 1 levels in benign prostate tissue in men with incident prostate cancer were positively associated with the Gleason score (P=0.01 and inversely associated with dietary antioxidant intake (P=0.03. In prostate cancer tissue, Trx 1 levels were associated with erythrocyte glutathione peroxidase activity (P=0.01. No association was found for other erythrocyte enzymes. Greater Gleason score of malignant tissue corresponds to a greater difference in Trx 1 levels between malignant and benign tissue (P=0.04. Conclusion. These results suggest that the redox status of prostate tissue is associated with prostate cancer grade and both endogenous and exogenous antioxidants.

  12. The Effects of Activating Prior Topic and Metacognitive Knowledge on Text Comprehension Scores

    Science.gov (United States)

    Kostons, Danny; van der Werf, Greetje

    2015-01-01

    Background: Research on prior knowledge activation has consistently shown that activating learners' prior knowledge has beneficial effects on learning. If learners activate their prior knowledge, this activated knowledge serves as a framework for establishing relationships between the knowledge they already possess and new information provided to…

  13. A melanoma risk score in a Brazilian population Um escore de risco para melanoma em uma população brasileira

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    Lucio Bakos

    2013-04-01

    Full Text Available BACKGROUND: Important risk factors for cutaneous melanoma (CM are recognized, but standardized scores for individual assessment must still be developed. OBJECTIVES: The objective of this study was to develop a risk score of CM for a Brazilian sample. METHODS: To verify the estimates of the main risk factors for melanoma, derived from a meta-analysis (Italian-based study, and externally validate them in a population in southern Brazil by means of a case-control study. A total of 117 individuals were evaluated. Different models were constructed combining the summary coefficients of different risk factors, derived from the meta-analysis, multiplied by the corresponding category of each variable for each participant according to a mathematical expression. RESULTS: the variable that best predicted the risk of CM in the studied population was hair color (AUC: 0.71; 95% CI: 0.62-0.79. Other important factors were freckles, sunburn episodes, and skin and eye color. Consideration of other variables such as common nevi, elastosis, family history, and premalignant lesions did not improve the predictive ability of the models. CONCLUSION: The discriminating capacity of the proposed model proved to be superior or comparable to that of previous risk models proposed for CM. FUNDAMENTOS: importantes fatores de risco para melanoma cutâneo são reconhecidos, mas escores padronizados para avaliação individual ainda precisam ser elaborados. OBJETIVOS: o objetivo deste estudo foi desenvolver um escore de risco de melanoma cutâneo para uma amostra brasileira. MÉTODOS: verificar as estimativas dos principais fatores de risco para melanoma, derivado de uma meta-análise (estudo de base italiano e, externamente, validar em uma população do sul do Brasil por um estudo caso-controle. Um total de 117 indivíduos foram avaliados. RESULTADOS: a variável com maior poder preditivo para o risco de melanoma cutâneo na população estudada foi a cor do cabelo (AUC: 0

  14. Apgar score

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/003402.htm Apgar score To use the sharing features on this page, ... birth. Virginia Apgar, MD (1909-1974) introduced the Apgar score in 1952. How the Test is Performed The ...

  15. The role of physical activity and fitness on the metabolic syndrome in adolescents: effect of different scores. The AFINOS Study.

    Science.gov (United States)

    Martínez-Gómez, D; Eisenmann, J C; Moya, J M; Gómez-Martínez, S; Marcos, A; Veiga, O L

    2009-09-01

    The aim of this study was to examine the associations of objectively measured physical activity (PA) and cardiorespiratory fitness (CRF) with different continuous metabolic syndrome (MetS) scores in adolescents. A cross-sectional sub-sample of 202 adolescents (99 girls), aged 13-17 years, were selected from the AFINOS Study. Body mass index, sum of 6 skindfold, waist circumference, systolic and diastolic blood pressure, insulin, glucose, triacylglycerol, and HDL-cholesterol levels were determined. Moderate PA (MPA), vigorous PA (VPA) and moderate to vigorous PA (MVPA) were assessed by the ActiGraph accelerometer for 7 consecutive days and CRF was estimated by the 20-m shuttle run test. Three continuous MetS scores were calculated according to the methodology of the Corpus Christi Child Heart Study (CCCHS), the Aerobic Center Longitudinal Study (ACLS), and the European Youth Heart Study (EYHS). VPA and MVPA were significantly related with CRF. Only CRF, and not patterns of PA, was inversely and independently associated with the three MetS scores although with different magnitudes (ranged: beta = 0.22 to 0.36, p < 0.05). A significant VPA x CRF interaction (p = 0.011) was found using the ACLS MetS score. Trends across VPA-CRF groups were significantly different with ACLS and EYHS (p = 0.002 and p = 0.006, respectively), but not with CCCHS (p = 0.313) continuous MetS scores. These findings support the key role of CRF on the MetS and the relevance of PA, especially VPA, to provide CRF in adolescents. A unified pediatric definition of MetS might minimize the discrepancies among studies.

  16. Associations of prepartum body condition score with occurrence of clinical endometritis and resumption of postpartum ovarian activity in dairy cattle.

    Science.gov (United States)

    Kadivar, Ali; Ahmadi, Mohammad Rahim; Vatankhah, Mahmood

    2014-01-01

    This study was performed to investigate the effect of periparturient body condition score on the occurrence of clinical endometritis and postpartum resumption of ovarian activity in dairy cows. Eighty-seven lactating Holstein cows, fed with a total mixed ration diet, were included into the study. Body condition scoring (using a 5-point scale with quarter-point divisions) was performed by the same investigator using the visual technique every 2 weeks, from 2 weeks before until 6 weeks after calving. Palpation of the reproductive tract and ultrasonographic assessment of ovaries for detection of corpus luteum using a rectal linear probe was also performed at 2, 4, and 6 weeks after calving. Cows with clinical endometritis had significantly lower body condition score (BCS) than normal cows at all weeks pre- and postcalving, and cows that did not ovulate until 45 days after calving had a significantly lower BCS pre- and postpartum. Cows that did not ovulate until 45 days after calving also lost more BCS from 2 weeks before to 4 weeks after calving. Besides, first ovulation after calving take occurred later in cows with clinical endometritis compared to normal cows (P BCS is a risk factor for postpartum endometritis and delayed cyclicity in dairy cows. BCS loss from dry-off to early lactation and occurrence of clinical endometritis can significantly affect postpartum ovarian activity.

  17. A cross-sectional study of the Birmingham Vasculitis Activity Score version 3 in systemic vasculitis.

    LENUS (Irish Health Repository)

    Suppiah, Ravi

    2011-05-01

    Assessment of disease activity in vasculitis can be achieved using the BVAS, a clinical checklist of relevant symptoms, signs and features of active disease. The aim of this study was to revalidate the BVAS version 3 (BVAS v. 3) in a cohort of patients with systemic vasculitis.

  18. Anti-Hepatitis B Virus Activity of Chickweed [<em>Stellaria mediaem> (L. Vill.] Extracts in HepG2.2.15 Cells

    Directory of Open Access Journals (Sweden)

    Donghao Xie

    2012-07-01

    Full Text Available <em>Stellaria media em>(Linn. Villars is a traditional Chinese medicine that has been used for over 200 years, mainly for the treatment of dermatitis and other skin diseases. It has also been used as an anti-viral agent. All the fresh chickweed juice samples used in this study were prepared using macroporous resin and ultrafiltration technology. The anti-hepatitis B virus (HBV activity of <em>S. media em>was evaluated<em> in vitroem> using the human HBV-transfected liver cell line HepG2.2.15. The concentrations of hepatitis B surface antigen (HBsAg and hepatitis B e antigen (HBeAg in HepG2.2.15 cell culture medium were determined by enzyme-linked immunosorbent assay (ELISA after <em>S. mediaem>-n (SM-n treatment for 6 or 9 days. HBV DNA was quantified using transcription-mediated amplification and real-time polymerase chain reaction. In HepG2.2.15 cells, 30 μg/mL SM-3 effectively suppressed the secretion of HBsAg and HBeAg with inhibition rates of 27.92% and 25.35% after 6 days of treatment, respectively. Consistent with the reduction in HBV antigens, SM-3 also reduced the level of HBV DNA in a dose-dependent manner. The characterization and quantitation of the chemical composition of SM-3 showed the presence of flavonoid C-glycosides, polysaccharides, and protein, which exhibited diverse antiviral activities. In conclusion, our results demonstrate that SM-3 possesses potential anti-HBV activity> in vitroem>. This is the first report demonstrating the anti-HBV effects of <em>S. mediaem>, which is currently under early development as a potential anti-HBV drug candidate.

  19. DAS28 score vs. ultrasound examination for assessment of rheumatoid arthritis disease activity: comparison and discussion of pros and cons.

    Science.gov (United States)

    Barczyńska, Tacjana Anna; Dura, Marta; Blumfield, Einat; Węgierska, Małgorzata; Żuchowski, Pawel; Wilińska-Jankowska, Arnika; Jeka, Sławomir

    2015-01-01

    Rheumatoid arthritis (RA) is a chronic systemic connective tissue disease which is characterized by symetrical multiple joints involvement and extra-articular symptoms. Current EULAR diagnostic criteria for RA include disease activity parameters, such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), which are used to calculate disease activity scores, including DAS and DAS28. Recently attempts have been made to assess disease activity using imaging diagnostic modalities, such as magnetic resonance imaging (MRI) and ultrasonography (US). Due to significant progress in therapy effectiveness and early RA diagnosis possibility, imaging modalities become increasingly meaningful and many clinical trials confirm their usefulness. However, there are no consistent criteria for objective assessment of therapy effectiveness based on US. Moreover, it is not US availability that limits its common use, but rather significant variability between operators. This is why US remains only an additional tool to assess therapy efficacy with regard to DAS/DAS28 index.

  20. Apgar Scores

    Science.gov (United States)

    ... Stages Listen Español Text Size Email Print Share Apgar Scores Page Content Article Body As soon as your ... the syringe, but is blue; her one minute Apgar score would be 8—two points off because she ...

  1. Lack of utility of risk score and gynecological examination for screening for sexually transmitted infections in sexually active adolescents

    Directory of Open Access Journals (Sweden)

    Côrtes Rejane LM

    2009-03-01

    Full Text Available Abstract Background Sexually transmitted infections constitute the main health risk among adolescents. In developing countries the diagnosis and treatment of cervical infections is based on the syndromic approach. In this study we estimated the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae among female adolescents from a Health Sector of the city of Goiânia, Brazil, and validated cervicitis diagnosis using World Health Organization/Ministry of Health risk score and gynecological examination. Methods A cross-sectional community-based sample of 914 15- to 19-year-old female teenagers was randomly selected and referred to the local Family Health Program. Of these, 472 (51.6% were sexually active and gynecological examinations were carried out for 427. Endocervical samples were collected to perform the polymerase chain reaction for C. trachomatis and N. gonorrhoeae. Performance of risk score, the presence of mucopurulent discharge, friability, ectopia and pain during cervical maneuver were compared with the presence of C. trachomatis or N. gonorrhoeae or both. Results The prevalence of C. trachomatis and N. gonorrhoeae was 14.5% and 2.1%, respectively. The risk score had a specificity of 31.9% (95% confidence interval, 21.2 to 44.2 and a positive predictive value of 20.8% (95% confidence interval, 13.5 to 29.7. Friability was the component of the gynecological examination that presented the best performance with a sensitivity of 43.5%, specificity of 81.0%, and 30.6% of positive predictive value. Conclusion The prevalence of infection by C. trachomatis and N. gonorrhoeae was high among these sexually active adolescents. The syndromic approach is clearly inadequate for screening and treating these infections in this population. Therefore, the implantation of other strategies to control these infections among adolescents is urgently required.

  2. UPDRS ACTIVITY OF DAILY LIVING SCORE AS MARKER OF PARKINSON’S DISEASE PROGRESSION

    OpenAIRE

    Harrison, Madaline B.; Wylie, Scott A.; Frysinger, Robert C.; Patrie, James T.; Huss, Diane S.; Currie, Lillian J.; Wooten, G. Frederick

    2009-01-01

    The Activities of Daily Living (ADL) subscore of the UPDRS captures the impact of Parkinson’s Disease (PD) on daily function and may be less affected than other subsections by variability associated with drug cycle and motor fluctuations. We examined UPDRS mentation, ADL and motor subscores in 888 patients with idiopathic PD. Multiple linear regression analyses determined the association between disease duration and UPDRS subscores as a function of medication status at examination and in a su...

  3. Systems view of adipogenesis via novel omics-driven and tissue-specific activity scoring of network functional modules

    Science.gov (United States)

    Nassiri, Isar; Lombardo, Rosario; Lauria, Mario; Morine, Melissa J.; Moyseos, Petros; Varma, Vijayalakshmi; Nolen, Greg T.; Knox, Bridgett; Sloper, Daniel; Kaput, Jim; Priami, Corrado

    2016-07-01

    The investigation of the complex processes involved in cellular differentiation must be based on unbiased, high throughput data processing methods to identify relevant biological pathways. A number of bioinformatics tools are available that can generate lists of pathways ranked by statistical significance (i.e. by p-value), while ideally it would be desirable to functionally score the pathways relative to each other or to other interacting parts of the system or process. We describe a new computational method (Network Activity Score Finder - NASFinder) to identify tissue-specific, omics-determined sub-networks and the connections with their upstream regulator receptors to obtain a systems view of the differentiation of human adipocytes. Adipogenesis of human SBGS pre-adipocyte cells in vitro was monitored with a transcriptomic data set comprising six time points (0, 6, 48, 96, 192, 384 hours). To elucidate the mechanisms of adipogenesis, NASFinder was used to perform time-point analysis by comparing each time point against the control (0 h) and time-lapse analysis by comparing each time point with the previous one. NASFinder identified the coordinated activity of seemingly unrelated processes between each comparison, providing the first systems view of adipogenesis in culture. NASFinder has been implemented into a web-based, freely available resource associated with novel, easy to read visualization of omics data sets and network modules.

  4. Validity of PALMS GPS Scoring of Active and Passive Travel Compared to SenseCam

    Science.gov (United States)

    Carlson, Jordan A.; Jankowska, Marta M.; Meseck, Kristin; Godbole, Suneeta; Natarajan, Loki; Raab, Fredric; Demchak, Barry; Patrick, Kevin; Kerr, Jacqueline

    2014-01-01

    Purpose To assess validity of the Personal Activity Location Measurement System (PALMS) for deriving time spent walking/running, bicycling, and in vehicle, using SenseCam as the comparison. Methods 40 adult cyclists wore a Qstarz BT-Q1000XT GPS data logger and SenseCam (camera worn around neck capturing multiple images every minute) for a mean of 4 days. PALMS used distance and speed between GPS points to classify whether each minute was part of a trip (yes/no), and if so, the trip mode (walking/running, bicycling, in vehicle). SenseCam images were annotated to create the same classifications (i.e., trip yes/no and mode). 2×2 contingency tables and confusion matrices were calculated at the minute-level for PALMS vs. SenseCam classifications. Mixed-effects linear regression models estimated agreement (mean differences and intraclass correlations [ICCs]) between PALMS and SenseCam with regards to minutes/day in each mode. Results Minute-level sensitivity, specificity, and negative predictive value were ≥88%, and positive predictive value was ≥75% for non mode-specific trip detection. 72–80% of outdoor walking/running minutes, 73% of bicycling minutes, and 74–76% of in-vehicle minutes were correctly classified by PALMS. For minutes/day, PALMS had a mean bias (i.e., amount of over or under estimation) of 2.4–3.1 minutes (11–15%) for walking/running, 2.3–2.9 minutes (7–9%) for bicycling, and 4.3–5 minutes (15–17%) for vehicle time. ICCs were ≥.80 for all modes. Conclusions PALMS has validity for processing GPS data to objectively measure time walking/running, bicycling, and in vehicle in population studies. Assessing travel patterns is one of many valuable applications of GPS in physical activity research that can improve our understanding of the determinants and health outcomes of active transportation as well as its impact on physical activity. PMID:25010407

  5. Effects of type of physical exercise and leisure activities on the depression scores of obese Brazilian adolescent girls

    Directory of Open Access Journals (Sweden)

    Stella S.G.

    2005-01-01

    Full Text Available Several studies have indicated that depressive states may lead to hypokinesia with diminished metabolic rate and energy use. Hypokinesia associated with certain eating behaviors may lead to an unfavorable energy balance that can contribute to the emergence and prevalence of obesity among children and adults. The purpose of the present study was to examine the possibility of reducing depression inventory scores in female adolescents with third-degree obesity while testing the effectiveness of different exercise programs in reducing anxiety and depression scores. The sample consisted of 40 female subjects (mean age 16 ± 1.56 years divided into 4 groups (aerobic training, anaerobic training, leisure activities, and control. Subjects had a body mass index of 95% or more in relation to the 50th percentile. The aerobic program consisted of three ergometric bicycle sessions per week over a 3-month period (12 weeks and the activities were prescribed after determining the anaerobic ventilatory threshold (VO2 threshold. Anaerobic training was based on the Wingate anaerobic power test. The leisure program consisted of a varied range of activities (games, exercises, etc.. A nutritionist interviewed the members of these two groups and the control group every week in order to adapt them to the nutritional guidelines proposed for the study. The study showed that all three programs (aerobic exercise, anaerobic exercise and leisure activities were effective in reducing body mass. However, we found a significant reduction when analyzing the depression scores only for aerobic exercise (18.9 ± 9.33 to 10.6 ± 9.56 or 43.9% but no significant alterations for anaerobic exercise (11.36 ± 5.23 to 9.63 ± 4.78 or 15.22% and leisure (17.28 ± 7.55 to 15.07 ± 7.54 or 12.78%, thus indicating that in principle this type of activity could be included to improve emotional well-being of obese adolescent girls.

  6. Association of a multibiomarker disease activity score at multiple time-points with radiographic progression in rheumatoid arthritis: results from the SWEFOT trial

    Science.gov (United States)

    Hambardzumyan, Karen; Bolce, Rebecca J; Saevarsdottir, Saedis; Forslind, Kristina; Wallman, Johan K; Cruickshank, Scott E; Sasso, Eric H; Chernoff, David; van Vollenhoven, Ronald F

    2016-01-01

    Objectives In rheumatoid arthritis (RA), predictive biomarkers for subsequent radiographic progression (RP) could improve therapeutic choices for individual patients. We previously showed that the multibiomarker disease activity (MBDA) score in patients with newly diagnosed RA identified patients at risk for RP. We evaluated the MBDA score at multiple time-points as a predictor of RP during 2 years of follow-up. Methods A subset of patients with RA (N=220) from the Swedish Farmacotherapy (SWEFOT) trial were analysed for MBDA score, disease activity score of 28 joints (DAS28), C reactive protein (CRP) and erythrocyte sedimentation rate (ESR) at baseline (BL), month 3 and year 1, for predicting RP based on modified Sharp/van der Heijde scores at BL, year 1 and year 2. Results Patients with persistently low MBDA (44) MBDA scores. Among methotrexate non-responders with a high MBDA score at BL or month 3, significantly more of those who received triple therapy had RP at year 2 compared with those who received antitumour necrosis factor therapy. Conclusions Measuring the MBDA score both before and during treatment in RA was useful for the assessment of individual patient risk for RP during 2 years of follow-up. In comparison with low CRP, ESR or DAS28, a low MBDA score at any time-point was associated with numerically lower proportions of RP. Trial registration number NCT00764725. PMID:26958364

  7. Comparação entre diferentes escores de risco de mortalidade em unidade de tratamento intensivo neonatal Comparison between different mortality risk scores in a neonatal intensive care unit

    Directory of Open Access Journals (Sweden)

    Mariani Schlabendorff Zardo

    2003-10-01

    Full Text Available OBJETIVO: Avaliar peso de nascimento e os escores como preditores de mortalidade neonatal em unidade de terapia intensiva neonatal, comparando os seus resultados. MÉTODOS: Foram avaliados 494 recém-nascidos admitidos em uma unidade de terapia intensiva neonatal (UTIN de um hospital geral de Porto Alegre, RS, logo após o nascimento, entre março de 1997 e junho de 1998. Foram avaliados o peso de nascimento e os escores considerando a variável óbito durante a internação na UTI. Os critérios de exclusão foram: alta ou óbito da UTIN com menos de 24 horas de internação, recém-nascidos cuja internação não ocorreu logo após o nascimento, protocolo de estudo incompleto e malformações congênitas incompatíveis com a vida. Para avaliação do CRIB (Clinical Risk Index for Babies foram considerados somente os pacientes com peso de nascimento inferior a 1.500 g. Foram calculadas as curvas ROC (Receiver Operating Characteristics Curve para SNAP (Score for Neonatal Acute, SNAP-PE (Score for Neonatal Acute Physiology Perinatal Extension, SNAP II, SNAP-PE II, CRIB e peso de nascimento. RESULTADOS: Dos 494 pacientes, 44 faleceram (8,9% de mortalidade. Dos 102 recém-nascidos com peso de até 1.500 g, 32 (31,3% faleceram. As áreas abaixo da curva ROC variaram de 0,81 a 0,94. Todos os escores avaliados mostraram áreas abaixo da curva ROC sem diferenças estatisticamente significativas. Os escores de risco de mortalidade estudados apresentaram um melhor desempenho que o peso de nascimento, especialmente em recém-nascidos com peso de nascimento igual ou menor que 1.500 g. CONCLUSÕES: Todos os escores de mortalidade neonatal apresentaram melhor desempenho e foram superiores ao peso de nascimento como medidores de risco de óbito hospitalar para recém-nascidos internados em UTIN.OBJECTIVES: To evaluate and compare birthweight and scores as predictors of neonatal mortality in a Neonatal Intensive Care Unit (NICU. METHODS: The survey included

  8. UPDRS activity of daily living score as a marker of Parkinson's disease progression.

    Science.gov (United States)

    Harrison, Madaline B; Wylie, Scott A; Frysinger, Robert C; Patrie, James T; Huss, Diane S; Currie, Lillian J; Wooten, G Frederick

    2009-01-30

    The activities of daily living (ADL) subscore of the Unified Parkinson's Disease Rating Scale (UPDRS) captures the impact of Parkinson's disease (PD) on daily function and may be less affected than other subsections by variability associated with drug cycle and motor fluctuations. We examined UPDRS mentation, ADL and motor subscores in 888 patients with idiopathic PD. Multiple linear regression analyses determined the association between disease duration and UPDRS subscores as a function of medication status at examination and in a subset of patients with multiple examinations. Independent of medication status and across cross-sectional and longitudinal analyses, ADL subscores showed a stronger and more stable association with disease duration than other UPDRS subscores after adjusting for age of disease onset. The association between disease duration and the motor subscore depended on medication status. The strong association between ADL subscore and disease duration in PD suggests that this measure may serve as a better marker of disease progression than signs and symptoms assessed in other UPDRS sections.

  9. Effects of a therapeutic climbing program on muscle activation and SF-36 scores of patients with lower back pain.

    Science.gov (United States)

    Kim, Se-Hun; Seo, Dong-Yel

    2015-03-01

    [Purpose] This study examined the effects of lumbar stability exercises on chronic lower back pain by using a therapeutic climbing program on lumbar muscle activity and function. [Subjects and Methods] Thirty adult subjects with chronic back pain participated. The subjects were assigned to 2 exercise groups, namely the lumbar stabilization (Mat Ex) and therapeutic climbing exercise groups (TC Ex). Each group trained for 30 minutes, 3 times a week for 4 weeks. The Short-form 36-item Questionnaire (SF-36) was administered and the surface electromyographic (sEMG) activities of the lumbar muscles were measured. [Results] Both therapy groups showed significant increases in the SF-36 score, and the increase was greater in the TC Ex group. Significant increases in the sEMG activities of the lumbar muscles were found in both groups. The increases in the sEMG activities of the rectus abdominis and internal and external oblique muscles of the abdomen were greater in the TC Ex group than in the Mat Ex group. [Conclusion] These findings demonstrate that TC Ex, which is similar to normal lumbar stabilization exercise, is effective at activating and improving the function of the lumbar muscles. These results suggest that TC Ex has a positive impact on the stabilization of the lumbar region.

  10. Modelling Cost-Effectiveness of Biologic Treatments Based on Disease Activity Scores for the Management of Rheumatoid Arthritis in Spain

    Directory of Open Access Journals (Sweden)

    Ariel Beresniak

    2011-01-01

    Full Text Available Background. The objective of this simulation model was to assess the cost-effectiveness of different biological treatment strategies based on levels of disease activity in Spain, in patients with moderate to severe active RA and an insufficient response to at least one anti-TNF agent. Methods. Clinically meaningful effectiveness criteria were defined using DAS28 scores: remission and Low Disease Activity State (LDAS thresholds. Monte-Carlo simulations were conducted to assess cost-effectiveness over 2 years of four biological sequential strategies composed of anti-TNF agents (adalimumab, infliximab, abatacept or rituximab, in patients with moderate to severe active RA and an insufficient response to etanercept as first biological agent. Results. The sequential strategy including etanercept, abatacept and adalimumab appeared more efficacious over 2 years (102 days in LDAS compared to the same sequence including rituximab as second biological option (82 days in LDAS. Cost-effectiveness ratios showed lower costs per day in LDAS with abatacept (427 € compared to rituximab as second biological option (508 €. All comparisons were confirmed when using remission criteria. Conclusion. Model results suggest that in patients with an insufficient response to anti-TNF agents, the biological sequences including abatacept appear more efficacious and cost-effective than similar sequences including rituximab or cycled anti-TNF agents.

  11. Evaluation of Crohn's disease activity: Initial validation of a magnetic resonance enterography global score (MEGS) against faecal calprotectin

    Energy Technology Data Exchange (ETDEWEB)

    Makanyanga, Jesica C.; Dikaios, Nikolaos [University College London, Centre for Medical Imaging, London (United Kingdom); Pendse, Doug; Atkins, Elaine; Cuthbertson, Terry [University College London Hospitals, Department of Specialist Radiology, London (United Kingdom); Bloom, Stuart; McCartney, Sara; Forbes, Alastair [University College London Hospitals, Department of Gastroenterology, London (United Kingdom); Helbren, Emma; Punwani, Shonit; Halligan, Steve; Taylor, Stuart A. [University College London, Centre for Medical Imaging, London (United Kingdom); University College London Hospitals, Department of Specialist Radiology, London (United Kingdom)

    2014-02-15

    To develop an MRI enterography global score (MEGS) of Crohn's disease (CD) activity compared with a reference standard of faecal calprotectin (fC), C-reactive protein (CRP) and Harvey-Bradshaw index (HBI). Calprotectin, CRP and HBI were prospectively recorded for 71 patients (median age 33, male 35) with known/suspected CD undergoing MRI enterography. Two observers in consensus scored activity for nine bowel segments, grading mural thickness, T2 signal, mesenteric oedema, T1 enhancement and pattern, and haustral loss. Segmental scores were multiplied according to disease length. Five points each were added for lymphadenopathy, comb sign, fistulae and abscesses to derive the MEGS. A previously validated MRI CD activity score (CDAS) was also calculated. MRI scores were correlated with clinical references using Spearman's rank. A logistic regression diagnostic model was built to discriminate active (fC > 100 μg/g) from inactive disease. MEGS and CDAS were significantly correlated with fC (r = 0.46, P < 0.001) and (r = 0.39, P = 0.001) respectively. MEGS correlated with CRP (r = 0.39, P = 0.002). The model for discriminating active from inactive disease achieved an area under the receiver-operating curve of 0.75 and 0.66 after leave-one-out analysis. A magnetic resonance enterography global score (MEGS) of CD activity correlated significantly with fC levels. (orig.)

  12. Avaliação da carga de trabalho no pós-operatório de cirurgia cardíaca segundo o Nursing Activities Score

    Directory of Open Access Journals (Sweden)

    Larissa Bertacchini de Oliveira

    2015-12-01

    Full Text Available RESUMO Objetivo Identificar os fatores associados à carga de trabalho de enfermagem no cuidado a pacientes no pós-operatório de cirurgia cardíaca. Método Estudo de coorte prospectivo, conduzido com 187 pacientes da Unidade de Terapia Intensiva Cirúrgica (UTI do Instituto do Coração. Os dados foram coletados nas primeiras 24 e 72 horas do paciente na UTI. A variável dependente foi a carga de trabalho calculada por meio do Nursing Activities Score (NAS e as independentes foram de natureza demográfico-clínicas e escores de morbimortalidade. Para análise dos dados utilizou-se os testes de Wilcoxon-Mann-Whitney e de correlação de Spearman, e a regressão linear com modelo de efeitos mistos. Resultados A maioria dos pacientes era do sexo masculino (59,4%, com média de idade de 61 anos (±12,7 e 43,9% desenvolveram algum tipo de complicação no pós-operatório. Nas 24 horas, a carga de trabalho foi de 82,4% (±3,4 e foi de 58,1% (±3,4 nas 72 horas. Os fatores associados ao aumento do NAS foram: tempo de internação do paciente na UTI (p=0,036 e a presença de complicações (p<0,001. Conclusão A gravidade do paciente nas 24 horas, em oposição a inúmeros estudos, não influenciou no aumento da carga de trabalho, a qual se mostrou associada ao tempo de internação e às complicações.

  13. Score Correlation

    OpenAIRE

    Fabián, Z. (Zdeněk)

    2010-01-01

    In this paper, we study a distribution-dependent correlation coefficient based on the concept of scalar score. This new measure of association of continuous random variables is compared by means of simulation experiments with the Pearson, Kendall and Spearman correlation coefficients.

  14. Multibiomarker disease activity score and C-reactive protein in a cross-sectional observational study of patients with rheumatoid arthritis with and without concomitant fibromyalgia

    Science.gov (United States)

    Hackett, James; Frits, Michelle; Iannaccone, Christine K.; Shadick, Nancy A.; Weinblatt, Michael E.; Segurado, Oscar G.; Sasso, Eric H.

    2016-01-01

    Objectives. To examine the association between a multibiomarker disease activity (MBDA) score, CRP and clinical disease activity measures among RA patients with and without concomitant FM. Methods. In an observational cohort of patients with established RA, we performed a cross-sectional analysis comparing MBDA scores with CRP by rank correlation and cross-classification. MBDA scores, CRP and clinical measures of disease activity were compared between patients with RA alone and RA with concomitant FM (RA and FM) by univariate and multivariate analyses. Results. CRP was ⩽1.0 mg/dl for 184 of 198 patients (93%). MBDA scores correlated with CRP (r = 0.755, P < 0.001), but were often discordant, being moderate or high for 19%, 55% and 87% of patients with CRP ⩽0.1, 0.1 to ⩽0.3, or 0.3 to ⩽1.0 mg/dl, respectively. Among patients with CRP ⩽1.0 mg/dl, swollen joint count (SJC) increased linearly across levels of MBDA score, both with (P = 0.021) and without (P = 0.004) adjustment for CRP, whereas CRP was not associated with SJC. The 28-joint-DAS-CRP, other composite measures, and their non-joint-count component measures were significantly greater for patients with RA and FM (n = 25) versus RA alone (n = 173) (all P ⩽ 0.005). MBDA scores and CRP were similar between groups. Conclusion. MBDA scores frequently indicated RA disease activity when CRP did not. Neither one was significantly greater among patients with RA and FM versus RA alone. Thus, MBDA score may be a useful objective measure for identifying RA patients with active inflammation when CRP is low (⩽1.0 mg/dl), including RA patients with concomitant FM. PMID:26608972

  15. Responsiveness of the Ankylosing Spondylitis Disease Activity Score (ASDAS) and clinical and MRI measures of disease activity in a 1-year follow-up study of patients with axial spondyloarthritis treated with tumour necrosis factor alpha inhibitors

    DEFF Research Database (Denmark)

    Pedersen, Susanne Juhl; Sørensen, Inge Juul; Hermann, Kay-Geert A

    2010-01-01

    To investigate construct validity and responsiveness of the novel ankylosing spondylitis (AS) disease activity score (ASDAS) in patients with spondyloarthritis (SpA).......To investigate construct validity and responsiveness of the novel ankylosing spondylitis (AS) disease activity score (ASDAS) in patients with spondyloarthritis (SpA)....

  16. An external validation study reporting poor correlation between the claims-based index for rheumatoid arthritis severity and the disease activity score

    OpenAIRE

    Desai, Rishi J.; Solomon, Daniel H.; Michael E Weinblatt; Shadick, Nancy; Kim, Seoyoung C.

    2015-01-01

    Introduction: We conducted an external validation study to examine the correlation of a previously published claims-based index for rheumatoid arthritis severity (CIRAS) with disease activity score in 28 joints calculated by using C-reactive protein (DAS28-CRP) and the multi-dimensional health assessment questionnaire (MD-HAQ) physical function score. Methods: Patients enrolled in the Brigham and Women’s Hospital Rheumatoid Arthritis Sequential Study (BRASS) and Medicare were identified and t...

  17. Aplicação do escore CRIB como preditor de óbito em unidade de terapia intensiva neonatal: uma abordagem ampliada The use of CRIB score as mortality predictor at neonatal intensive care unit: an extended approach

    Directory of Open Access Journals (Sweden)

    Luiz Fernando C. Nascimento

    2004-06-01

    Full Text Available OBJETIVOS: avaliar o uso do escore CRIB (Clinical Risk Index for Babies em todos os recém-nascidos internados em Unidade de Terapia Intensiva Neonatal (UTIN e comparar seus resultados com peso ao nascer e idade gestacional. MÉTODOS: estudo observacional, envolvendo todos os recém-nascidos internados na UTIN do Hospital Universitário de Taubaté. As variáveis foram escore CRIB, peso ao nascer, idade gestacional, uso de surfactante, cateterização umbilical, asfixia neonatal e óbito. Foram comparadas as médias do escore CRIB, peso ao nascer e idade gestacional segundo óbito. Foram estimados os valores da sensibilidade, especificidade, valores preditivos positivo e negativo e risco relativo e criadas curvas Receiver Operating Characteristic (ROC para CRIB, peso ao nascer e idade gestacional. Utilizou-se da técnica t de Student e qui-quadrado de tendência linear. A significância estatística foi alfa = 5%. RESULTADOS: óbito esteve associado a maiores valores do CRIB; houve tendência de mais casos com asfixia, uso de surfactante, cateterização umbilical e óbitos com as classes maiores do CRIB. A curva ROC relativa ao CRIB foi maior que as relativas ao peso ao nascer e idade gestacional. CONCLUSÕES: o escore CRIB foi bom preditor do óbito quando aplicado em todos os RN.OBJECTIVES: to evaluate the CRIB (Clinical Risk Index for Babies score as mortality predictor in all newborn at Neonatal Intensive Care Unit (NICU and to compare with birthweight and gestational age. METHODS: observational study with newborn admitted at NICU of University Hospital of Taubaté. The variables were CRIB score, birth weight, gestational age, use of surfactant, umbilical catheter, neonatal asphyxia and death. The association between CRIB score and other variables was estimated. The values of sensitivity, specificity, predictive and negative values and relative risk and 95% confidence interval of were estimated and created ROC (Receiver Operating

  18. Activity patterns of the stone marten <em>Martes foinaem> Erxleben, 1777, in relation to some environmental factors

    Directory of Open Access Journals (Sweden)

    Mario Posillico

    1995-12-01

    Full Text Available Abstract Three stone martens (2 males, 1 female <em>Martes foinaem> Erxleben, 1777, were radio-tracked for 4, 2.5 and 12 months respectively, in a rural hilly area in Siena County, Central Italy. Food habits were assessed by faecal analysis, as percentage of occurrence and estimated volume. Diel, nocturnal, diurnal and crepuscular activity were measured as the proportion of active fixes on a 48 hours/fortnight basis. Seasonal variation of all activities was assessed and correlated to mean T°C, daylength, food and trophic niche breadth. Daily time budgets were also measured and compared between months and seasons. Fruits were the staple food in summer/autumn, followed by vertebrates and invertebrates. Vertebrates and invertebrates were the main food source in winter and spring. No significant difference of activity could be found between the three animals. Diel activity reached its maximum in summer, and decreased significantly throughout the rest of the year. Die1 activity did not differ significantly between subsequent seasons, whereas a statistically significant difference was found between every other season. Nocturnal activity peaked in winter and dropped in summer. It significantly differed between seasons but for spring vs. summer and autumn vs. winter. Diurnal activity differed significantly between seasons, but for spring vs. summer, when it reached its maximum, and for autumn vs. winter when it was at its minimum. Crepuscular activity remained constant throughout the year. The 24-hour distribution of active fixes showed a bimodal pattern in spring and summer, while in autumn and winter the activity pattern was unimodal, with a nocturnal peak. Time budget differed between seasons, but for autumn and winter vs. spring. Significant correlations between activities and abiotical variables (except rainfall were direct, but for nocturnal activity. No significant correlation was found with precipitation. Activity was not

  19. Prehospital electrocardiographic acuteness score of ischemia is inversely associated with neurohormonal activation in STEMI patients with severe ischemia

    DEFF Research Database (Denmark)

    Fakhri, Yama; Schoos, Mikkel Malby; Sejersten-Ripa, Maria;

    2017-01-01

    BACKGROUND: Elevated levels of N-terminal pro brain natriuretic peptide (NT-proBNP) are associated with adverse cardiovascular outcome after ST elevation myocardial infarction (STEMI). We hypothesized that decreasing acuteness-score (based on the electrocardiographic score by Anderson-Wilkins acu...

  20. Prediction of Upper Limb Recovery, General Disability, and Rehabilitation Status by Activity Measurements Assessed by Accelerometers or the Fugl-Meyer Score in Acute Stroke

    NARCIS (Netherlands)

    Gebruers, Nick; Truijen, Steven; Engelborghs, Sebastiaan; De Deyn, Peter P.

    2014-01-01

    Objective This study investigated the clinical predictive value of the Fugl-Meyer Assessment (FMA) arm score and the upper limb activity assessed by accelerometers in patients with hemiparesis after acute stroke. Design The prospective cohort (n = 129) was recruited from a general hospital; activity

  1. Young Zanzibari Children with Iron Deficiency, Iron Deficiency Anemia, Stunting, or Malaria Have Lower Motor Activity Scores and Spend Less Time in Locomotion

    Science.gov (United States)

    Motor activity improves cognitive and social-emotional development through a child’s exploration of his or her physical and social environment. This study assessed anemia, iron deficiency, hemoglobin (Hb), length-for-age Z-score (LAZ), and malaria infection as predictors of motor activity in 771 chi...

  2. Genetic effect on apgar score

    Directory of Open Access Journals (Sweden)

    Carla Franchi-Pinto

    1999-03-01

    Full Text Available Intraclass correlation coefficients for one- and five-min Apgar scores of 604 twin pairs born at a southeastern Brazilian hospital were calculated, after adjusting these scores for gestational age and sex. The data support a genetic hypothesis only for 1-min Apgar score, probably because it is less affected by the environment than 4 min later, after the newborns have been under the care of a neonatology team. First-born twins exhibited, on average, better clinical conditions than second-born twins. The former showed a significantly lower proportion of Apgar scores under seven than second-born twins, both at 1 min (17.5% vs. 29.8% and at 5 min (7.2% vs. 11.9%. The proportion of children born with "good" Apgar scores was significantly smaller among twins than among 1,522 singletons born at the same hospital. Among the latter, 1- and 5-min Apgar scores under seven were exhibited by 9.2% and 3.4% newborns, respectively.Os coeficientes de correlação intraclasse foram calculados para os índices de Apgar 1 e 5 minutos após o nascimento de 604 pares de gêmeos em uma maternidade do sudeste brasileiro, depois que esses índices foram ajustados para idade gestacional e sexo. Os dados obtidos apoiaram a hipótese genética apenas em relação ao primeiro índice de Apgar, provavelmente porque ele é menos influenciado pelo ambiente do que 4 minutos depois, quando os recém-nascidos já estiveram sob os cuidados de uma equipe de neonatologistas. Os gêmeos nascidos em primeiro lugar apresentaram, em média, melhor estado clínico que os nascidos em segundo lugar, visto que os primeiros mostraram uma proporção de índices de Apgar inferiores a 7 significativamente menor do que os nascidos em segundo lugar, tanto um minuto (17,5% contra 29,8% quanto cinco minutos após o nascimento (7,2% contra 11,9%. A proporção de recém-nascidos com índices de Apgar que indicam bom prognóstico foi significativamente menor nos gêmeos do que em 1.522 conceptos

  3. Escores de consumo alimentar e níveis lipêmicos em população de São Paulo, Brasil Food consumption scores and serum lipids levels in the population of São Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Nélida Schmid de Fornés

    2002-02-01

    Full Text Available OBJETIVO: Analisar o padrão de consumo alimentar avaliado por meio de escores de consumo e relacionar esses escores com os níveis de colesterol total e de lipoproteínas de baixa e alta densidades em população da área metropolitana de São Paulo. MÉTODOS: Estudo transversal realizado no município de Cotia, São Paulo, em amostra representativa de 1.045 adultos, foram determinados níveis de lipídeos séricos e a ingestão de alimentos por meio da freqüência de consumo alimentar. Foram utilizados escores de padrão de consumo, estabelecendo um peso para cada categoria de consumo baseado na freqüência anual, obtendo-se, assim, a distribuição quintilar do escore I (alimentos considerados de risco para doenças cardiovasculares e escore II (alimentos protetores. Foram comparados os valores médios das lipoproteínas para cada um dos quintis pela análise de variância, e foram verificadas possíveis relações entre os escores de consumo e as frações de lipídeos séricos, mediante modelos de regressão linear múltipla (stepwise forward. RESULTADOS: Observou-se aumento significativo dos níveis médios de lipídeos, segundo quintis de consumo do escore I para colesterol total e para lipoproteína de baixa densidade-colesterol, e constatou-se um comportamento inverso e significativo dos níveis desses lipídeos séricos em relação ao escore II. O escore I correlacionou-se positivamente e significativamente a esses lipídeos, e o escore II apresentou correlação inversa e significativa com esses constituintes sangüíneos. CONCLUSÕES: Em estudos populacionais, a análise da freqüência de consumo de alimentos por meio de escores pode ser um método de escolha para avaliar qualidade de dieta e de seu potencial efeito nos níveis séricos de colesterol total e de lipoproteínas de baixa densidade.OBJECTIVE: To study food patterns assessed using scores of consumption and their relationship with serum total cholesterol (TOTAL-C, low

  4. Prebiotic activity score and bioactive compounds in longan (Dimocarpus longan Lour.): influence of pectinase in enzyme-assisted extraction.

    Science.gov (United States)

    Thitiratsakul, Boossara; Anprung, Pranee

    2014-09-01

    The optimal extraction of bioactive compounds from longan fruit pulp using Pectinex® Ultra SP-L pectinase hydrolysis of the fruit homogenate was evaluated. The highest degree of hydrolysis (DH), as determined by the amount of reducing sugars released from the longan pulp, was obtained at a pectinase concentration of 2.5 % (v/w) (257 polygalacturonase units/g fruit) for 4 h. The level of bioactive compounds obtained from the pectinase-treated longan pulp increased with increasing DH to a maximum at the highest DH (21 %) obtained, with an antioxidant activity of 0.083 EC50 μg fresh mass (FM)/μg diphenyl-(2,4,6-trinitrophenyl)iminoazanium and 92.7 μM Trolox equivalent/g FM, respectively. The total phenolic and flavonoid contents in the 21 % DH extract were 196.0 mg gallic acid equivalents/g FM and 19.6 mg catechin equivalents/g FM, respectively. The 21 % DH longan extract showed an enhanced (3.6- to 4.0-fold) inhibition of lipid peroxidation of oil compared to the untreated (0 % DH) extract. In addition, the 21 % DH longan extract had the highest soluble dietary fiber content, which was related to the decreased particle size of 345 μM, and displayed enhanced prebiotic activity scores of 1.69 and 1.44 for Lactobacillus acidophilus La5 and Bifidabacterium lactis Bb12, respectively. Most of the 33 detected volatile compounds differed in their relative proportions after enzymic extraction (15 increased, 15 decreased with three showing no significant change) with the 0 % and 21 % DH hydrolysates exhibiting 25 and 22 different volatile compounds, respectively, with 11 and eight unique compounds between them, respectively.

  5. Uma arquitetura para combinação de classificadores otimizada por métodos de poda com aplicação em credit scoring

    OpenAIRE

    Silva Filho, Luiz Vieira e

    2014-01-01

    Sistemas de Múltiplos Classificadores (Multiple Classifiers Systems - MCS) se baseiam na ideia de que combinar a opinião de vários especialistas pode produzir melhores resultados do que quando se usa apenas um especialista. Diversas técnicas de MCS foram desenvolvidas, apresentando pontos fortes e fracos, a depender do contexto em que são aplicadas. Este trabalho propõe uma arquitetura para MCS que visa potencializar a complementaridade entre essas técnicas, possuindo dois o...

  6. Validity and Agreement between the 28-Joint Disease Activity Score Based on C-Reactive Protein and Erythrocyte Sedimentation Rate in Patients with Rheumatoid Arthritis

    DEFF Research Database (Denmark)

    Nielung, Louise; Christensen, Robin; Danneskiold-Samsøe, Bente;

    2015-01-01

    Objective. To validate the agreement between the 28-joint disease activity score based on erythrocyte sedimentation rate (DAS28-ESR) and the 28-joint disease activity score based on C-reactive protein (DAS28-CRP) in a group of Danish patients with rheumatoid arthritis (RA). Methods. Data from 109...... Danish RA patients initiating biologic treatment were analysed at baseline and following one year of treatment. Participants were retrospectively enrolled from a previous cohort study and were considered eligible for this project if CRP and ESR were measured at baseline and at the follow-up visit...

  7. Aplicação do EuroSCORE na cirurgia de revascularização miocárdica em hospitais públicos do Rio de Janeiro Application of the EuroSCORE in coronary artery bypass surgery in public hospitals in Rio de Janeiro, Brazil

    Directory of Open Access Journals (Sweden)

    Márcio Roberto Moraes de Carvalho

    2010-06-01

    Full Text Available FUNDAMENTOS: Modelos de estratificação de risco são utilizados em cirurgia para avaliar risco de morte. OBJETIVO: Fazer análise crítica da aplicação do EuroSCORE (ES em amostras de prontuários de 2692 pacientes submetidos à cirurgia de revascularização miocárdica em 4 hospitais públicos do município do Rio de Janeiro, no período de 1999 a 2003. MÉTODOS: Foram selecionadas, em quatro hospitais públicos da cidade do Rio de Janeiro, amostras aleatórias de 150 prontuários de pacientes por hospital, sobreviventes e óbitos. Aplicou-se o ES utilizando-se o modelo logístico. A letalidade observada e prevista pelo modelo foi comparada. A aferição do poder discriminante foi estimada pela área sob a curva ROC. RESULTADOS: Localizados 546 dos 600 prontuários selecionados. Observou-se significativa diferença entre prevalências dos fatores de risco entre nossa população e européia. Letalidade prevista foi 3,62% (IC-95%: 3,47-3,78 e observada estimada foi 12,22% (IC-95%- 10,99-13,46. Em todas as faixas de risco, há subestimação da letalidade prevista, com diferenças notáveis entre prevista e observada.Área sob a curva ROC foi estimada em 0,62. CONCLUSÃO: Diferenças das prevalências dos fatores de risco que compõem o ES associado ao baixo poder discriminatório desaconselham a utilização do modelo em nosso meio sem devidos ajustes.BACKGROUND: Risk stratification models are used to assess the risk of death in surgery. OBJECTIVE: To conduct a critical analysis of the EuroSCORE logistic model (ES application in 2,692 patients undergoing Coronary Artery Bypass Grafting (CABG in four public hospitals in the Rio de Janeiro Municipality, from 1999 through to December 2003. METHODS: Random samples of 150 medical records for surviving and deceased patients were selected at four public hospitals in the City of Rio de Janeiro. The ES was applied, using the logistical model. The observed lethality rate and that forecast by the

  8. Aplicação do índice de intervenção terapêutica em unidade de terapia intensiva pediátrica = Therapeutic intervention scoring system application in a pediatric intensive care unit

    Directory of Open Access Journals (Sweden)

    Canabarro, Simone Travi

    2009-01-01

    Full Text Available Introdução: Índices de gravidade buscam estimar a severidade da doença, sendo o Therapeutic Intenvention Scoring System-28 (Sistema de Escore de Intervenção Terapêutica - TISS-28, usado em Unidades de Terapia Intensiva, um índice indireto para estimar intervalos de gravidade da doença que mais recentemente tem sido usado para relacionar a carga de trabalho de enfermagem. Objetivo: Revisar cada item/definição operacional do índice de intervenção terapêutica (TISS- 28 procedendo-se uma releitura com o objetivo de sistematizar a prática da coleta de dados em Unidade de Terapia Intensiva Pediátrica (UTIP. Materiais e Métodos: Pesquisa de revisão integrativa de literatura médica e de enfermagem por meio da base de dados Medical Literature Analysis and Retrieval System Online (MEDLINE e Scientific Electronic Library Online (SciELO usando os termos Unidades de terapia intensiva (Intensive care units, Escalas (scales e Therapeutic Intervention Scoring System-28 ou TISS-28. Os artigos foram selecionados de acordo com sua relevância, segundo a opinião dos autores. Resultados: Estudos prévios demonstram que o uso do TISS-28 em UTI de pacientes adultos têm contribuído na avaliação evolutiva clínica da piora do paciente, além de associações entre óbito e pontuações elevadas. Os itens/definições operacionais avaliados neste escore são revisados visando facilitar a interpretação de cada item na aplicação diária do TISS-28, em Unidade de Terapia Intensiva Pediátrica. Conclusão: A avaliação diária das 28 variáveis do TISS permite a obtenção de um perfil evolutivo das crianças internadas, podendo auxiliar no conhecimento do agravamento clínico do quadro da criança internada e de seu prognóstico

  9. Activation of human T lymphocytes by <em>Leishmania> lipophosphoglycan

    DEFF Research Database (Denmark)

    Kemp, M; Theander, T G; Handman, E

    1991-01-01

    This study describes Leishmania antigen-induced activation of lymphocytes isolated from Kenyan donors, previously treated for visceral leishmaniasis, and from Danish and Kenyan controls. Peripheral blood mononuclear cells (PBMC) from cured Kala-Azar patients proliferated and produced Interferon...... 63 failed to activate PBMC from any of the donors tested. These results show that the individuals cured from visceral leishmaniasis had expanded T-cell clones recognizing LPG, conceivably as a result of Leishmania infection. The LPG preparation was without detectable protein contamination. Thus...

  10. Blood monocyte oxidative burst activity in acute <em>P. falciparumem> malaria

    DEFF Research Database (Denmark)

    Nielsen, H; Theander, T G

    1989-01-01

    The release of superoxide anion from blood monocytes was studied in eight patients with acute primary attack P. falciparum malaria. Before treatment a significant enhancement of the oxidative burst prevailed, which contrasts with previous findings of a depressed monocyte chemotactic responsiveness....... During treatment and after clinical recovery the activity of superoxide anion release normalized in all patients....

  11. Nutritional Quality of Breakfast and Physical Activity Independently Predict the Literacy and Numeracy Scores of Children after Adjusting for Socioeconomic Status

    Science.gov (United States)

    O'Dea, Jennifer A.; Mugridge, Anna C.

    2012-01-01

    Health-related behaviors [physical activity (PA), nutritional quality of breakfast and sleep]; personal variables (self-esteem, attitudes to PA and gender) and socioeconomic status (SES) (school SES and parental education), were examined in relation to literacy and numeracy scores of 824 grade 3-7 children. Participants completed a questionnaire,…

  12. Structure-activity studies: in vitro antileishmanial and antimalarial activities of anthraquinones from <em>Morinda lucidaem>

    DEFF Research Database (Denmark)

    Sittie, A A; Lemmich, E; Olsen, C E

    1999-01-01

    Anthraquinones have been isolated by bioassay-guided fractionation from Morinda lucida. Structure-activity studies show that an aldehyde group at C-2 and a phenolic hydroxy group at C-3 enhance the activity of the anthraquinones against the growth of Plasmodium falciparum and promastigotes of Lei...

  13. Acetylcholinesterase inhibitory activity of lycopodane-type alkaloids from the Icelandic <em>Lycopodium annotinumem> ssp. <em>alpestre>

    DEFF Research Database (Denmark)

    Halldórsdóttir, Elsa Steinunn; Jaroszewski, Jerzy W; Olafsdottir, Elin Soffia

    2010-01-01

    determined. Conformation of acrifoline was characterized using NOESY spectroscopy and molecular modelling. The isolated alkaloids were evaluated for their in vitro inhibitory activity against acetylcholinesterase and butyrylcholinesterase. Ligand docking studies based on mutated 3D structure of Torpedo...

  14. Handedness and behavioural inhibition system/behavioural activation system (BIS/BAS) scores: A replication and extension of Wright, Hardie, and Wilson (2009).

    Science.gov (United States)

    Beaton, Alan A; Kaack, Imogen H; Corr, Philip J

    2015-01-01

    The Annett Hand Preference Questionnaire (AHPQ) as modified by Briggs and Nebes was administered along with Carver and White's behavioural inhibition system (BIS) and behavioural activation system (BAS) scale and a shortened form of the Big Five personality questionnaire to 92 university students. After eliminating the data from five respondents who reported having changed handedness and one outlier, there was a significant sex difference in mean BIS scores, with females (n = 43) scoring higher than males (n = 43). Replicating the results of Wright, Hardie and Wilson, non-right-handers (n = 36) had significantly higher mean BIS score than right-handers (n = 50). Controlling for sex of participant, neuroticism and BAS sub-scale scores in hierarchical regression analyses left this BIS effect substantially unaffected. There was no handedness or sex difference on any of the three BAS sub-scales. Further analyses revealed no association between strength, as distinct from direction, of handedness and BIS (or BAS) scores. The findings are discussed with reference to recent developments in reinforcement sensitivity theory on which BIS/BAS variables are based.

  15. The relationship between the acoustic behaviour and surface activity of killer whales (<em>Orcinus orcaem>) that feed on herring (<em>Clupea harengusem>)

    DEFF Research Database (Denmark)

    Simon, Malene Juul; McGregor, Peter K.; Ugarte, Fernando

    2007-01-01

    We describe the acoustic behaviour of piscivorous killer whales in Norwegian and Icelandic waters. Whales were assigned to one of three activities (feeding, travelling or other), and sound recordings were made in their proximity with a single hydrophone and a digital audiotape (DAT) recorder....... A quantitative analysis of the production of pulsed calls, whistles and echolocation clicks in the three activities revealed that there was a significant effect of activity on the production of these sound types. Both killer whales in Icelandic and Norwegian waters produced high rates of clicks and calls during...... behaviour, we suggest that the killer whales in Icelandic and Norwegian waters belong to the same ecotype: Scandinavian herring-eating killer whales. Udgivelsesdato: 18 April 2007...

  16. The apo structure of sucrose hydrolase from <em>Xanthomonas campestrisem> pv. <em>campestris em>shows an open active-site groove

    DEFF Research Database (Denmark)

    Champion, Elise; Remaud-Simeon, Magali; Skov, Lars Kobberøe;

    2009-01-01

    are reported. Sucrose hydrolysis catalyzed by the enzyme follows Michaelis-Menten kinetics, with a K(m) of 60.7 mM and a k(cat) of 21.7 s(-1). The structure of the enzyme was solved at a resolution of 1.9 A in the resting state with an empty active site. This represents the first apo structure from subfamily 4...

  17. Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines.

    Science.gov (United States)

    Hylsová, Michaela; Carbain, Benoit; Fanfrlík, Jindřich; Musilová, Lenka; Haldar, Susanta; Köprülüoğlu, Cemal; Ajani, Haresh; Brahmkshatriya, Pathik S; Jorda, Radek; Kryštof, Vladimír; Hobza, Pavel; Echalier, Aude; Paruch, Kamil; Lepšík, Martin

    2017-01-27

    We present comprehensive testing of solvent representation in quantum mechanics (QM)-based scoring of protein-ligand affinities. To this aim, we prepared 21 new inhibitors of cyclin-dependent kinase 2 (CDK2) with the pyrazolo[1,5-a]pyrimidine core, whose activities spanned three orders of magnitude. The crystal structure of a potent inhibitor bound to the active CDK2/cyclin A complex revealed that the biphenyl substituent at position 5 of the pyrazolo[1,5-a]pyrimidine scaffold was located in a previously unexplored pocket and that six water molecules resided in the active site. Using molecular dynamics, protein-ligand interactions and active-site water H-bond networks as well as thermodynamics were probed. Thereafter, all the inhibitors were scored by the QM approach utilizing the COSMO implicit solvent model. Such a standard treatment failed to produce a correlation with the experiment (R(2) = 0.49). However, the addition of the active-site waters resulted in significant improvement (R(2) = 0.68). The activities of the compounds could thus be interpreted by taking into account their specific noncovalent interactions with CDK2 and the active-site waters. In summary, using a combination of several experimental and theoretical approaches we demonstrate that the inclusion of explicit solvent effects enhance QM/COSMO scoring to produce a reliable structure-activity relationship with physical insights. More generally, this approach is envisioned to contribute to increased accuracy of the computational design of novel inhibitors.

  18. Rapid activity prediction of HIV-1 integrase inhibitors: harnessing docking energetic components for empirical scoring by chemometric and artificial neural network approaches

    Science.gov (United States)

    Thangsunan, Patcharapong; Kittiwachana, Sila; Meepowpan, Puttinan; Kungwan, Nawee; Prangkio, Panchika; Hannongbua, Supa; Suree, Nuttee

    2016-06-01

    Improving performance of scoring functions for drug docking simulations is a challenging task in the modern discovery pipeline. Among various ways to enhance the efficiency of scoring function, tuning of energetic component approach is an attractive option that provides better predictions. Herein we present the first development of rapid and simple tuning models for predicting and scoring inhibitory activity of investigated ligands docked into catalytic core domain structures of HIV-1 integrase (IN) enzyme. We developed the models using all energetic terms obtained from flexible ligand-rigid receptor dockings by AutoDock4, followed by a data analysis using either partial least squares (PLS) or self-organizing maps (SOMs). The models were established using 66 and 64 ligands of mercaptobenzenesulfonamides for the PLS-based and the SOMs-based inhibitory activity predictions, respectively. The models were then evaluated for their predictability quality using closely related test compounds, as well as five different unrelated inhibitor test sets. Weighting constants for each energy term were also optimized, thus customizing the scoring function for this specific target protein. Root-mean-square error (RMSE) values between the predicted and the experimental inhibitory activities were determined to be <1 (i.e. within a magnitude of a single log scale of actual IC50 values). Hence, we propose that, as a pre-functional assay screening step, AutoDock4 docking in combination with these subsequent rapid weighted energy tuning methods via PLS and SOMs analyses is a viable approach to predict the potential inhibitory activity and to discriminate among small drug-like molecules to target a specific protein of interest.

  19. Escore de cálcio na avaliação da aterosclerose em pacientes com HIV/AIDS Calcium score in the evaluation of atherosclerosis in patients with HIV/Aids

    Directory of Open Access Journals (Sweden)

    Verônica Soares Monteiro

    2011-11-01

    Full Text Available FUNDAMENTO: A terapia antirretroviral aumentou drasticamente a expectativa de vida em pacientes com HIV/AIDS, embora a aterosclerose esteja associada a uma terapia de longo prazo. OBJETIVO: Investigar a prevalência de aterosclerose em pacientes com AIDS submetidos à terapia antirretroviral e a influência de tratamentos de diferentes regimes e durações. MÉTODOS: Pacientes com HIV/AIDS foram abordados durante consultas de rotina. Aqueles que estiveram em terapia antirretroviral por, pelo menos, dois anos tiveram o sangue coletado para análise do perfil lipídico e da glicemia em jejum e foram submetidos à tomografia computadorizada cardíaca para quantificação do escore de cálcio dentro de seis dias, no máximo. A aterosclerose foi definida como escore de cálcio maior que zero (CAC > 0. Fatores de risco tradicionais, síndrome metabólica e o escore de Framingham foram analisados. RESULTADOS: Cinquenta e três pacientes realizaram tomografia computadorizada cardíaca: 50,94% eram do sexo masculino, com idade média de 43,4 anos; 20% tinham hipertensão; 3,77% tinham diabetes; 67,92% tinham hipercolesterolemia; 37,74% tinham hipertrigliceridemia; 47,17% tinham HDL baixo; 24,53% atenderam aos critérios para síndrome metabólica; 96,23% foram classificados no escore de Framingham como "baixo risco"; e 18,87% eram tabagistas. A duração média do tratamento antirretroviral foi de 58,98 meses. A aterosclerose coronária ocorreu em 11 pacientes (20,75%. A duração da terapia antirretroviral não se relacionou à aterosclerose (p = 0,41, e não houve diferenças significativas entre os diferentes esquemas antirretrovirais (p = 0,71. Entre os fatores de risco tradicionais, o tabagismo (OR = 27,20; p = 0,023 e a idade (OR = 20,59; p = 0,033 foram significativos na presença de aterosclerose. Havia tendência para uma associação positiva da aterosclerose com a hipercolesterolemia (OR = 8,30; p = 0,0668. CONCLUSÃO: Os fatores associados

  20. The Evolution of the EM Distribution in the Core of an Active Region

    CERN Document Server

    Del Zanna, Giulio; Mason, Helen; Subramanian, Srividya; O'Dwyer, Brendan

    2014-01-01

    We study the spatial distribution and evolution of the slope of the Emission Measure between 1 and 3~MK in the core active region NOAA~11193, first when it appeared near the central meridian and then again when it re-appeared after a solar rotation. We use observations recorded by the Extreme-ultraviolet Imaging Spectrometer (EIS) aboard Hinode, with a new radiometric calibration. We also use observations from the Atmospheric Imaging Assembly (AIA) aboard Solar Dynamics Observatory (SDO). We present the first spatially resolved maps of the EM slope in the 1--3~MK range within the core of the AR using several methods, both approximate and from the Differential Emission Measure (DEM). A significant variation of the slope is found at different spatial locations within the active region. We selected two regions that were not affected too much by any line-of-sight lower temperature emission. We found that the EM had a power law of the form EM~$\\propto T^{b}$, with b = 4.4$\\pm0.4$, and 4.6$\\pm0.4$, during the first...

  1. Discriminant validity of the Ankylosing Spondylitis Disease Activity Score (ASDAS) in patients with non-radiographic axial spondyloarthritis and ankylosing spondylitis: a cohort study.

    Science.gov (United States)

    Kilic, Erkan; Kilic, Gamze; Akgul, Ozgur; Ozgocmen, Salih

    2015-06-01

    The aim of this study was to assess discriminant validity of Ankylosing Spondylitis Disease Activity Score (ASDAS)-C-reactive protein (-CRP) and ASDAS-erythrocyte sedimentation rate (-ESR) and to compare with The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) as clinical tools for the measurement of disease activity in patients with non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS). Also, the cut-off values for ASDAS-CRP in nr-axSpA and AS is revisited. Patients with axSpA were recruited from Erciyes Spondyloarthritis Cohort (ESPAC) and were assessed for disease activity, quality of life and functional measures. The discriminatory ability of ASDAS-CRP and ASDAS-ESR was assessed using standardized mean differences and receiver operating characteristic (ROC) curves analysis. Optimal cut-off values for disease activity scores were calculated. Two hundred and eighty-seven patients with axSpA (nr-axSpA:132, AS:155) were included in this study. Two ASDAS versions and BASDAI had good correlations with patient's and physician's global assessment in both groups. Discriminatory ability of ASDAS-CRP, ASDAS-ESR and BASDAI were similar in patients with nr-axSpA and AS when the patients were assigned into low and high disease activity according to the ASAS partial remission, patient's and physician's global assessment scores (based on the comparison of ROC curves). ASDAS cut-off values are quite similar between groups indicating that ASDAS-CRP works similarly well in nr-axSpA and AS. The performance of ASDAS to discriminate low and high disease activity and cut-off values are quite similar in patients with AS and non-radiographic axial SpA.

  2. Diagnóstico da tuberculose em indígenas menores de quinze anos por meio de um sistema de pontuação em Mato Grosso do Sul Scoring system for the diagnosis of tuberculosis in indigenous children and adolescents under 15 years of age in the state of Mato Grosso do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Sandra Christo dos Santos

    2013-02-01

    Full Text Available OBJETIVO: Avaliar o processo diagnóstico da tuberculose pulmonar em indígenas menores de 15 anos, por meio do Sistema de Pontuação do Ministério da Saúde Modificado (SP-MSm, em crianças e adolescentes com resultados negativos na baciloscopia. MÉTODOS: Estudo descritivo retrospectivo de 49 casos de tuberculose em indígenas menores de 15 anos no estado do Mato Grosso do Sul entre 2007 e 2010. RESULTADOS: Dos 49 pacientes, 27 (56% eram menores de 5 anos, 33 (67% apresentavam sintomas sugestivos de tuberculose, 24 (49% tinham baixo peso, e 36 (73,5% haviam sido vacinados com BCG. O teste tuberculínico foi reator em 28 pacientes (57%. Dentre esses, 18 (64% apresentaram enduração > 10 mm. Foram realizadas radiografias de tórax em 37 pacientes (76%, sendo que 31 (84% fizeram apenas um exame. Desses 37 pacientes, os achados radiológicos eram sugestivos de tuberculose em 16 (43%, de infiltrado/condensação em 10 (27% e normais em 4 (11%. As Equipes de Saúde Indígena foram responsáveis pelo diagnóstico em 31 (63% dos casos, mas o SP-MS original só foi utilizado em 14 (45%. Os escores do SP-MSm foram determinados em 30 pacientes (61%. Dos 30 casos pontuados, os resultados dos escores indicaram diagnóstico de tuberculose muito provável, possível e pouco provável em 16 (53%, 11 (37% e 3 (10%, respectivamente. CONCLUSÕES: A proporção de diagnóstico muito provável e possível foi concordante com o diagnóstico padrão do serviço (90%, evidenciando a aplicabilidade epidemiológica do SP-MSm para o diagnóstico da tuberculose pulmonar em indígenas, de forma compatível com a realidade do serviço de saúde prestado.OBJECTIVE: To evaluate the process of diagnosing pulmonary tuberculosis in smear-negative indigenous children and adolescents under 15 years of age with the modified Brazilian National Ministry of Health Scoring System (mBNMH-SS. METHODS: This was a retrospective descriptive study involving 49 indigenous patients under

  3. Litter Control Achievement - Ohio 4-H Club Score Sheet [and] Activity Guides 1 through 7. 4-H Pilot Program 918.

    Science.gov (United States)

    Ohio State Univ., Columbus. Cooperative Extension Service.

    Seven activity guides, evaluation sheet, and club scoresheet have been prepared for Ohio 4-H clubs' litter education program. Topics of the seven activity guides include: (1) general guidelines and types of activities; (2) little known facts about waste/litter; (3) guidelines for a walking tour; (4) fact sheet (questionnaire) related to garbage;…

  4. Low bone mineral density in COPD patients with osteoporosis is related to low daily physical activity and high COPD assessment test scores

    Directory of Open Access Journals (Sweden)

    Liu WT

    2015-09-01

    Full Text Available Wen-Te Liu,1,2,* Han-Pin Kuo,3,* Tien-Hua Liao,4 Ling-Ling Chiang,1 Li-Fei Chen,3 Min-Fang Hsu,5 Hsiao-Chi Chuang,1 Kang-Yun Lee,2,6 Chien-Da Huang,3 Shu-Chuan Ho11School of Respiratory Therapy, College of Medicine, Taipei Medical University, 2Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, 3Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 4Department of Respiratory Therapy, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, 5Department of Healthcare Administration, Asia University, Wufeng, Taichung, 6Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan*These authors contributed equally to this workAbstract: COPD patients have an increased prevalence of osteoporosis (OP compared with healthy people. Physical inactivity in COPD patients is a crucial risk factor for OP; the COPD assessment test (CAT is the newest assessment tool for the health status and daily activities of COPD patients. This study investigated the relationship among daily physical activity (DPA, CAT scores, and bone mineral density (BMD in COPD patients with or without OP. This study included 30 participants. Ambulatory DPA was measured using actigraphy and oxygen saturation by using a pulse oximeter. BMD was measured using dual-energy X-ray absorptiometry. OP was defined as a T-score (standard deviations from a young, sex-specific reference mean BMD less than or equal to -2.5 SD for the lumbar spine, total hip, and femoral neck. We quantified oxygen desaturation during DPA by using a desaturation index and recorded all DPA, except during sleep. COPD patients with OP had lower DPA and higher CAT scores than those of patients without OP. DPA was significantly positively correlated with (lumbar spine, total hip, and femoral neck BMD (r=0.399, 0.602, 0.438, respectively

  5. Rocks: A Concrete Activity That Introduces Normal Distribution, Sampling Error, Central Limit Theorem and True Score Theory

    Science.gov (United States)

    Van Duzer, Eric

    2011-01-01

    This report introduces a short, hands-on activity that addresses a key challenge in teaching quantitative methods to students who lack confidence or experience with statistical analysis. Used near the beginning of the course, this activity helps students develop an intuitive insight regarding a number of abstract concepts which are key to…

  6. Nutritional quality of breakfast and physical activity independently predict the literacy and numeracy scores of children after adjusting for socioeconomic status.

    Science.gov (United States)

    O'Dea, Jennifer A; Mugridge, Anna C

    2012-12-01

    Health-related behaviors [physical activity (PA), nutritional quality of breakfast and sleep]; personal variables (self-esteem, attitudes to PA and gender) and socioeconomic status (SES) (school SES and parental education), were examined in relation to literacy and numeracy scores of 824 grade 3-7 children. Participants completed a questionnaire, and their national literacy and numeracy test scores were retrieved. Mothers (N = 755) completed a telephone interview. Students of highest school SES, maternal education, nutritional quality of breakfast, more sedentary time and female gender had higher literacy scores. SES, maternal education, male gender and total minutes of daily PA were predictors of numeracy with an interaction between greater total PA in boys and greater numeracy. Even though the socioeconomic factors that have predicted children's academic achievement for many decades are still clearly set in place, there are also other modifiable health influences that affect literacy and numeracy and are independent of SES. The current findings provide evidence for health educators and school administrators who may garner support for both breakfast programs and daily school PA for the dual purposes of health promotion as well as for the improvement of literacy and numeracy in settings in which social class may be acting against the educational interests of disadvantaged children.

  7. Fetal Biophysical Profile Scoring

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    H.R. HaghighatKhah

    2009-01-01

    significance. Fetal breathing movements, amniotic fluid volume, and the non-stress test are the most powerful variables. For example, when the biophysical profile score is 2, the perinatal mortality varies between 428/1000 with only fetal movement present to 66/1000 if the non-stress test is reactive and all of the ultrasound parameters are absent (Manning 1990b. Some authors have, therefore, proposed utilization of a modified biophysical profile that incorporates only the non-stress test and amniotic fluid volume (Miller 1996. Although the positive predictive value of these 2 tests is equivalent to a biophysical profile score of 6, the perinatal mortality is still increased over a normal test score of 8 or 10 (Manning 1990b. The false positive rate with the modified biophysical profile score is also substantially higher. "nConclusions: The fetus expresses its well being or compromised status through a number of different biophysical activities that are controlled by different central nervous system centers. The utilization of the biophysical score for antepartum surveillance in high-risk patients has resulted in a reduction in perinatal mortality when compared to historical controls. The appropriate management of the viable fetus with an abnormal biophysical profile score may also decrease long-term neurological morbidity (Manning 1998. "nIt is unlikely that in the future additional variables will be added to the biophysical profile score. However, perhaps the incorporation of the fetal state (i.e., eye movements and Doppler flow studies of specific fetal vessels (umbilical artery, middle cerebral artery, ductus venosus will be incorporated into a complete assessment of the fetal condition "n "nTable 1. Components of the 30 Minute Biophysical Profile Score "nComponent "nDefinition "nFetal movements "n> 3 body or limb movements "nFetal tone "nOne episode of active extension and flexion of the limbs; opening and closing of hand "nFetal breathing movements "n>1

  8. A clinically prognostic scoring system for patients receiving highly active antiretroviral therapy: results from the EuroSIDA study

    DEFF Research Database (Denmark)

    Lundgren, Jens Dilling; Mocroft, Amanda; Gatell, Jose M;

    2002-01-01

    The risk of clinical progression for human immunodeficiency virus (HIV)-infected persons receiving treatment with highly active antiretroviral therapy (HAART) is poorly defined. From an inception cohort of 8457 HIV-infected persons, 2027 patients who started HAART during prospective follow-up wer...

  9. Um novo escore para opacificação tomográfica dos seios paranasais em crianças A new score for tomographic opacificacation of paranasal sinuses in children

    Directory of Open Access Journals (Sweden)

    Severino Aires de Araújo Neto

    2010-08-01

    Full Text Available Vários escores foram criados para medir alterações dos seios paranasais pela tomografia computadorizada. Atualmente o sistema de Lund e Makcay é o mais aceito. Contudo, em crianças seu resultado pode sofrer interferência do processo de desenvolvimento. OBJETIVO: Medir precisão e acurácia de um novo escore tomográfico, denominado "razão opacificação-desenvolvimento", cujo resultado traduz a percentagem de opacificação da área sinusal. MATERIAL E MÉTODOS: Estudo prospectivo transversal em pacientes de até 18 anos, submetidos à tomografia computadorizada de seios paranasais para avaliação de rinossinusite. Dois radiologistas avaliaram independentemente cada exame, utilizando o sistema de Lund e o escore aqui proposto. RESULTADO: A razão opacificação-desenvolvimento apresentou concordância intra e interobservador, equivalentes àqueles atingidos pelo sistema de Lund (Kappa > 0,60. Utilizando o sistema de Lund como padrão-ouro, o ponto de corte da razão opacificação-desenvolvimento com melhor acurácia foi o valor de 15, com sensibilidade e especificidade próximas de 90%. Houve forte correlação linear entre as escalas dos dois métodos (r > 0,90. CONCLUSÃO: A razão opacificação-desenvolvimento é um método preciso, com boa correlação com o sistema de Lund. Um ponto de corte de 15 pode ser utilizado para definir teste positivo.Many score methods have been created to measure paranasal sinus abnormalities seen under CT scan. Currently, the Lund-Mackay staging system is widely accepted. However, its results may be affected by the development in children. AIM: To assess the precision and accuracy of a new tomography score, called "opacification-development ratio". It translates the percentage of sinus area that is opaque. MATERIALS AND METHODS: A cross-sectional study was prospectively conducted in patients ranging from 0-18 years of age who underwent CT scan assessment of rhinosinusitis. Two independent radiologists

  10. <em>α>-Glucosidase Inhibitory Constituents from <em>Acanthopanax senticosusem> Harm Leaves

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    Hai-Xue Kuang

    2012-05-01

    Full Text Available A new triterpene glycoside, 3-<em>O-[(α>-L-rhamnopyranosyl(1→2]-[<em>β>-D-glucuronopyranosyl-6-<em>O>-methyl ester]-olean-12-ene-28-olic acid (1 and a new indole alkaloid, 5-methoxy-2-oxoindolin-3-acetic acid methyl ester (5 were isolated from the leaves of <em>Acanthopanax senticosusem> Harms along with six known compounds. The structures of the new compounds were determined by means of 2D-NMR experiments and chemical methods. All the isolated compounds were evaluated for their glycosidase inhibition activities and compound 6 showed significant <em>α>-glucosidase inhibition activity.

  11. Peroxidase activity in Spondias dulcis = Atividade da peroxidase em Spondias dulcis

    Directory of Open Access Journals (Sweden)

    Lúcio Cardozo-Filho

    2010-10-01

    Full Text Available In this study, the best conditions to obtain crude extracts showingPeroxidase activity from Spondia dulcis (caja-mango were evaluated. Fresh fruits (25 g were blended in different sodium phosphate buffer (0.05 to 0.2 M with a pH varying from 3.0 to 9.0. The muddy material was centrifuged for 20 minutes. In order to improve POD activity, the crude extract was submitted to precipitation with ammonium sulfate at 90% saturation. This precipitated was re-suspended in sodium phosphate buffer 0.2 M pH 6.5 and then, optimum pH for activity assay (pH varying from 5.0 to 9.0 and thermal stability (exposure to different temperatures varying from 30 to 75ºC for periods between 0 to 15 minutes were determined. The best conditions for activity assay were in phosphate buffer 0.2 M at pH7.0. The results obtained for thermal inactivation study suggest that the heating at 75ºCfor 15 minutes inactivated 95% of initial POD activity.Foram avaliadas, neste trabalho, algumas condições para a obtenção de extratos brutos com atividade peroxidase de Spondias dulcis (cajá-manga. Frutas frescas (25 g foram trituradas com tampão fosfato de sódio (0,05 a 0,2 M em pHs diferentes (3,0 a 9,0. O material obtido foi centrifugado por 20 min. O extrato bruto foi submetido à precipitação com sulfato de amônio até 90% de saturação. Este precipitado foi ressuspenso em tampão fosfato de sódio 0,2 M pH 6,5 e, assim, o pH ótimo para o ensaio de atividade (pH que varia de 5,0 a 9,0 e a estabilidade térmica (exposição a temperaturas de 30, 60, 65, 70 e 75ºC por um período de 0 a 15 min. deste foram determinados. As melhores condições encontradas para o ensaio de atividade foram em tampão fosfato 0,2 M pH 7,0. Os resultados para a inativação térmica sugerem que o aquecimento a 75ºC por 15 mininativa 95% da atividade de POD inicial.

  12. Effect of ELF e.m. fields on metalloprotein redox-active sites

    CERN Document Server

    De Ninno, A; Ferrari, V; Gerardi, G; Barbaro, F; Badon, T; Bernardini, D

    2008-01-01

    The peculiarity of the distribution and geometry of metallic ions in enzymes pushed us to set the hypothesis that metallic ions in active-site act like tiny antennas able to pick up very feeble e.m. signals. Enzymatic activity of Cu2+, Zn2+ Superoxide Dismutase (SOD1) and Fe2+ Xanthine Oxidase (XO) has been studied, following in vitro generation and removal of free radicals. We observed that Superoxide radicals generation by XO is increased by a weak field having the Larmor frequency fL of Fe2+ while the SOD1 kinetics is sensibly reduced by exposure to a weak field having the frequency fL of Cu2+ ion.

  13. Tuberculose ativa entre profissionais de saúde em Portugal Active tuberculosis among health care workers in Portugal

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    José Castela Torres da Costa

    2011-10-01

    Full Text Available OBJETIVO: Determinar a incidência de tuberculose (TB ativa em uma coorte de profissionais de saúde (PS. MÉTODOS: Estudo descritivo dos casos de TB ativa identificados entre 2005 e 2010 no rastreio de medicina do trabalho efetuado em 6.112 PS. Casos de TB ativa foram definidos como aqueles com identificação de Mycobacterium tuberculosis por microscopia direta ou cultura; aqueles com sintomas ou sinais clínicos de TB e granuloma necrotizante, detectado por histologia; e aqueles com achados radiológicos consistentes com TB ativa. RESULTADOS: Dos 6.112 PS avaliados, houve 62 casos de TB ativa (TB pulmonar, em 43; TB pleural, em 15; TB ganglionar, em 2; TB do pericárdio, em 1; TB cutânea, em 1. Sete PS estavam assintomáticos no momento do diagnóstico. Dos 62 casos de TB ativa, a doença ocorreu nos primeiros 10 anos de exposição ocupacional em 48 e nos primeiros 5 anos em 36. A maioria dos casos verificou-se em médicos e enfermeiros (22 e 21, respectivamente. CONCLUSÕES: O impacto da TB em PS em Portugal é elevado. Os médicos e enfermeiros são os PS com o maior risco de desenvolver TB ativa. Tal como relatado em estudos prévios, parece haver um risco mais elevado de desenvolver essa doença nos primeiros anos de exposição. Em países de elevada incidência, o rastreio de TB nos PS é importante no controle da transmissão dessa doença.OBJECTIVE: To determine the incidence of active tuberculosis (TB in a cohort of health care workers (HCWs. METHODS: Descriptive study of active TB cases identified in an occupational health screening of 6,112 HCWs between 2005 and 2010. Cases of active TB were defined as those in which Mycobacterium tuberculosis was identified by direct microscopy or culture; those in which there were symptoms or clinical signs of TB and necrotizing granuloma, as detected by histology; and those in which the radiological findings were consistent with active TB. RESULTS: Among the 6,112 HCWs evaluated, we identified

  14. Screening and Analysis of the Potential Bioactive Components in Rabbit Plasma after Oral Administration of Hot-Water Extracts from Leaves of <em>B>ambusa em>>textilis em>McClure

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    Jia Sun

    2012-07-01

    Full Text Available <em>Bambusa textilisem> McClure is a traditional Chinese medicinal plant belonging to the Bambusoideae subfamily and used to treat chronic fever and infectious diseases. To investigate the bioactive compounds absorbed in the rabbit blood after oral administration of hot-<em>water extractem>>s from em>>the leaves of em>>B. textilisem> McClure, a validated chromatographic fingerprint method was established using LC-Q-TOF-MS. Twenty compounds in bamboo leaves and three potential bioactive compounds in rabbit plasma were detected. Of the twenty detected compounds <em>in vitroem>, fifteen of which were tentatively identified either by comparing the retention time and mass spectrometry data with that of reference compounds or by reviewing the literature. Three potential bioactive compounds, including (<em>E-p>-coumaric acid, (<em>Z-p>-coumaric acid, and apigenin-8-<em>C>-β-D-(2"-<em>O>-α-L-rhamnosyl-gluco-pyranoside, were detected in both <em>the leaves of em>>B. textilis em>McClure and rabbit plasma. Of the three compounds, apigenin-8-<em>C>-β-D-(2"-<em>O>-α-L-rhamnosylglucopyranoside was identified based on its UV, MS, and NMR spectra. This study provides helpful chemical information for further pharmacology and active mechanism research on <em>B. textilisem> McClure.

  15. Pharmacological Classification and Activity Evaluation of Furan and Thiophene Amide Derivatives Applying Semi-Empirical <em>ab initioem> Molecular Modeling Methods

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    Leszek Bober

    2012-05-01

    Full Text Available Pharmacological and physicochemical classification of the furan and thiophene amide derivatives by multiple regression analysis and partial least square (PLS based on semi-empirical <em>ab initioem> molecular modeling studies and high-performance liquid chromatography (HPLC retention data is proposed. Structural parameters obtained from the PCM (Polarizable Continuum Model method and the literature values of biological activity (antiproliferative for the A431 cells expressed as LD50 of the examined furan and thiophene derivatives was used to search for relationships. It was tested how variable molecular modeling conditions considered together, with or without HPLC retention data, allow evaluation of the structural recognition of furan and thiophene derivatives with respect to their pharmacological properties.

  16. Conclusion on the peer review of the pesticide risk assessment of the active substance [<em>Trichoderma atrovirideem> strain I-1237

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    European Food Safety Authority

    2012-10-01

    Full Text Available

    The conclusions of the European Food Safety Authority (EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State France, for the pesticide active substance <em>Trichoderma atrovirideem> strain I-1237 are reported. The context of the peer review was that required by Commission Regulation (EU No 188/2011. The conclusions were reached on the basis of the evaluation of the representative uses of Trichoderma atroviride strain I-1237 as a fungicide in vineyards and grapevine nursery. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are presented. Missing information identified as being required by the regulatory framework is listed.

  17. EM011 activates a survivin-dependent apoptotic program in human non-small cell lung cancer cells

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    Yates Clayton

    2009-10-01

    Full Text Available Abstract Background Lung cancer remains a leading cause of cancer death among both men and women in the United States. Treatment modalities available for this malignancy are inadequate and thus new drugs with improved pharmacological profiles and superior therapeutic indices are being continually explored. Noscapinoids constitute an emerging class of anticancer agents that bind tubulin but do not significantly alter the monomer/polymer ratio of tubulin. EM011, a rationally-designed member of this class of non-toxic agents, is more potent than the lead molecule, noscapine. Results Here we report that EM011 inhibited proliferation of a comprehensive panel of lung cancer cells with IC50's ranging from 4-50 μM. In A549 human non-small cell lung cancer cells, the antiproliferative activity was mediated through blockage of cell-cycle progression by induction of a transient but robust mitotic arrest accompanied by activation of the spindle assembly checkpoint. The mitotically-arrested A549 cells then override the activated mitotic checkpoint and aberrantly exit mitosis without cytokinesis resulting in pseudo G1-like multinucleated cells that either succumb directly to apoptosis or continue another round of the cell-cycle. The accumulated enormous DNA perhaps acts as genotoxic stress to trigger cell death. EM011-induced apoptotic cell death in A549 cells was associated with a decrease of the Bcl2/BAX ratio, activation of caspase-3 and cleavage of PARP. Furthermore, EM011 induced downregulation of survivin expression over time of treatment. Abrogation of survivin led to an increase of cell death whereas, overexpression caused decreased apoptosis. Conclusion These in vitro data suggest that EM011 mediates antiproliferative and proapoptotic activity in non-small cell A549 lung cancer cells by impeding cell-cycle progression and attenuating antiapoptotic signaling circuitries (viz. Bcl2, survivin. The study provides evidence for the potential usefulness of

  18. The Antimicrobial Efficacy of <em>Elaeis guineensisem>: Characterization, <em>in Vitroem> and <em>in Vivoem> Studies

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    Sreenivasan Sasidharan

    2012-04-01

    Full Text Available The urgent need to treat multi-drug resistant pathogenic microorganisms in chronically infected patients has given rise to the development of new antimicrobials from natural resources. We have tested <em>Elaeis guineensis em>Jacq> em>(Arecaceae methanol extract against a variety of bacterial, fungal and yeast strains associated with infections. Our studies have demonstrated that <em>E. guineensisem> exhibits excellent antimicrobial activity <em>in vitroem> and <em>in vivoem> against the bacterial and fungal strains tested. A marked inhibitory effect of the <em>E. guineensisem> extracts was observed against <em>C. albicansem> whereby <em>E. guineensisem> extract at ½, 1, or 2 times the MIC significantly inhibited <em>C. albicansem> growth with a noticeable drop in optical density (OD of the bacterial culture. This finding confirmed the anticandidal activity of the extract on <em>C. albicansem>. Imaging using scanning (SEM and transmission (TEM electron microscopy was done to determine the major alterations in the microstructure of the extract-treated <em>C. albicansem>. The main abnormalities noted via SEM and TEM studies were the alteration in morphology of the yeast cells. <em>In vivoem> antimicrobial activity was studies in mice that had been inoculated with <em>C. albicansem> and exhibited good anticandidal activity. The authors conclude that the extract may be used as a candidate for the development of anticandidal agent.<em> em>

  19. Greater Independence in Activities of Daily Living is Associated with Higher Health-Related Quality of Life Scores in Nursing Home Residents with Dementia

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    Charice S. Chan

    2015-06-01

    Full Text Available Health-related quality of life (HRQL for nursing home residents is important, however, the concept of quality of life is broad, encompasses many domains and is difficult to assess in people with dementia. Basic activities of daily living (ADL are measured routinely in nursing homes using the Resident Assessment Instrument-Minimum Data Set Version 2.0 (RAI-MDS and Functional Independence Measure (FIM instrument. We examined the relationship between HRQL and ADL to assess the future possibility of ADL dependency level serving as a surrogate measure of HRQL in residents with dementia. To assess ADL, measures derived from the RAI-MDS and FIM data were gathered for 111 residents at the beginning of our study and at 6-month follow-up. Higher scores for independence in ADL were correlated with higher scores for a disease-specific HRQL measure, the Quality of Life—Alzheimer’s Disease Scale. Preliminary evidence suggests that FIM-assessed ADL is associated with HRQL for these residents. The associations of the dressing and toileting items with HRQL were particularly strong. This finding suggests the importance of ADL function in HRQL. The RAI-MDS ADL scales should be used with caution to evaluate HRQL.

  20. Low Diversity Bacterial Community and the Trapping Activity of Metabolites from Cultivable Bacteria Species in the Female Reproductive System of the Oriental Fruit Fly, <em>Bactrocera dorsalisem> Hendel (Diptera: Tephritidae

    Directory of Open Access Journals (Sweden)

    Hongyu Zhang

    2012-05-01

    Full Text Available Our goal was to identify the bacteria inhabiting the reproductive system of the female oriental fruit fly, <em>Bactrocera dorsalisem> (Hendel, and evaluate the chemotaxis of <em>B>. <em>dorsalis> to the metabolites produced by the bacteria. Based on 16S rRNA-based polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE, 18 operational taxonomic units (OTUs were assigned to the five bacterial classes <em>Betaproteobacteria>, <em>Alphaproteobacteria>, <em>Gammaproteobacteria>, <em>Bacilli> and <em>Actinobacteria>. Nine OTUs were assigned to <em>Gammaproteobacteria>, which was the most highly represented class. <em>Enterobacteriaceae> constituted the dominant family, and within this family, three genera and five species were identified, including <em>Enterobacter sakazakiiem>, <em>Klebsiella> <em>oxytoca>, <em>Klebsiella> <em>pneumoniae,> Raoultellaem> <em>terrigena em>and <em>Enterobacter> <em>amnigenus>. In this set, the first two species were the dominant components, and the latter three species were the minor ones. Finally, we found that the metabolites produced by <em>R.> terrigenaem>, <em>K. oxytocaem> and <em>K.> pneumoniae em>were attractive to the <em>B.> dorsalisem> adults, and in field studies, <em>B.> dorsalisem> adults were most attracted to <em>K.> oxytocaem>. Collectively, our results suggest that the female reproductive system plays an important role in the transfer of enterobacteria from the gut to fruit. Our data may prompt the development of a female-targeted population control strategy for this fly.

  1. Relatieve validiteit van een vragenlijst naar lichamelijke activiteit volgens de beweegnorm [The relative validity of a questionnaire on physical activity according to the mean physical activity score

    NARCIS (Netherlands)

    Urlings, I.J.M.; Douwes, M.; Hildebrandt, V.H.; Stiggelbout, M.; Ooijendijk, W.T.M.

    2000-01-01

    The validity is explored of a short and simple questionnaire to differentiate populations into physical active and physical inactive persons according to recent guidelines on the required amount of physical activity (how many days a week they have physical activities for minimal 30 minutes a day). 2

  2. Mês de parição, condição corporal e resposta ao protocolo de inseminação artificial em tempo fixo em vacas de corte primíparas Calving date, body condition score, and response to a timed artificial insemination protocol in first-calving beef cows

    Directory of Open Access Journals (Sweden)

    M. Meneghetti

    2008-08-01

    Full Text Available No experimento I, foi avaliada a alteração da condição corporal (CC pré e pós-parto em 155 novilhas inseminadas para parir de setembro a dezembro. A CC foi avaliada mensalmente no pré e pós-parto, de junho a fevereiro. No experimento II, 538 vacas primíparas foram sincronizadas com o protocolo de inseminação artificial em tempo fixo (IATF que usou estradiol junto ao dispositivo intravaginal de progesterona (CIDR®. As taxas de ciclicidade, sincronização e concepção foram avaliadas por ultra-som. No experimento I, os animais que pariram primeiro tiveram maior (PIn experiment I, it was evaluated the body condition score (BCS change during pre and post-partum in 155 heifers, inseminated to calve from September to December. The BCS was monthly evaluated from June to February, during the pre and post-partum periods. In experiment II, 538 primiparous cows were synchronized with a timed artificial insemination (TAI protocol which used estradiol associated with an intravaginal progesterone device (CIDR®. The cyclicity, synchronization, and conception rates were evaluated by ultrasound. In experiment I, the animals that calved earlier had higher (P<0.001 reduction on BCS. In experiment II, it was observed higher BCS (P<0.0001 in cows with lower days in post-partum, higher (P<0.05 synchronization rate in cows with a better BCS, and also an increase (P<0.0001 in conception rate as BCS got better (increase in six percentual points in conception for each increase of 0.25 in BCS. Beef heifers should not calve earlier when is planned to submitt these animals to TAI at the beginning of the next breeding season.

  3. Avaliação da aplicabilidade de um modelo de credit scoring com varíaveis sistêmicas e não-sistêmicas em carteiras de crédito bancário rotativo de pessoas físicas An evaluation on the applicability of a credit scoring model, with systemic and non-systemic variables in revolving bank credit portfolio for individuals

    Directory of Open Access Journals (Sweden)

    José Odálio dos Santos

    2007-08-01

    Full Text Available As concessões de crédito rotativo às pessoas físicas (cheque especial e cartão de crédito vêm crescendo significativamente nos últimos anos, o que, em parte, é explicado pela relativa estabilização da economia, maior geração de empregos e êxito no controle da inflação - fatores que interferem diretamente na capacidade de pagamento dos tomadores. Paralelamente, observa-se uma maior exposição histórica dos Bancos ao risco de inadimplência, ou seja, o do não-recebimento (parcial ou total de créditos rotativos utilizados pelas pessoas físicas. Considerando o tamanho e a importância desse mercado aos grandes Bancos Comerciais e a economia como um todo, direciona-se essa pesquisa para: 1. detalhar os processos de análise subjetiva e objetiva de crédito realizada pelos principais Bancos privados nacionais; 2. abordar a função seletiva das taxas de juros em créditos rotativos; 3. destacar as principais características dos modelos de credit scoring e 4. propor um modelo de credit scoring para créditos rotativos composto por variáveis sistêmicas e não-sistêmicas, direcionado à redução do risco de inadimplência. A aplicabilidade do modelo proposto de credit scoring em uma amostra extraída da carteira de crédito de pessoas físicas de um importante Banco Comercial privado nacional de médio porte (Banco X - nome fictício, apresentou satisfatório índice de acerto na identificação de clientes prospectivos (96% e não-prospectivos (92%, levando à conclusão de que incluía e ponderava, adequadamente, as variáveis representativas da capacidade de pagamento dos tomadores.The concessions of revolving credit to consumers (guaranteed check and credit card have been growing significantly in the last few years, which is in part explained by the relative stabilization of the economy, higher levels of job creation and success in controlling inflation - factors that have a direct influence in the borrowers’ payment

  4. Efficient Heterologous Transformation of <em>Chlamydomonas> reinhardtiiem> <em>npq2em> Mutant with the Zeaxanthin Epoxidase Gene Isolated and Characterized from<em> Chlorella zofingiensisem>

    Directory of Open Access Journals (Sweden)

    Herminia Rodríguez

    2012-09-01

    Full Text Available In the violaxanthin cycle, the violaxanthin de-epoxidase and zeaxanthin epoxidase catalyze the inter-conversion between violaxanthin and zeaxanthin in both plants and green algae. The zeaxanthin epoxidase gene from the green microalga <em>Chlorella zofingiensisem> (<em>Czzep> has been isolated<em>. em>This gene encodes a polypeptide of 596 amino acids. A single copy of <em>Czzep> has been found in the <em>C. zofingiensisem> genome by Southern blot analysis. qPCR analysis has shown that transcript levels of <em>Czzep> were increased after zeaxanthin formation under high light conditions. The functionality of <em>Czzep> gene by heterologous genetic complementation in the <em>Chlamydomonas> mutant <em>npq2em>, which lacks zeaxanthin epoxidase (ZEP activity and accumulates zeaxanthin in all conditions, was analyzed. The <em>Czzep> gene was adequately inserted in the pSI105 vector and expressed in <em>npq2em>. The positive transformants were able to efficiently convert zeaxanthin into violaxanthin, as well as to restore their maximum quantum efficiency of the PSII (Fv/Fm. These results show that <em>Chlamydomonas> can be an efficient tool for heterologous expression and metabolic engineering for biotechnological applications.

  5. Duke Activity Status Index em Doenças Cardiovasculares: Validação de Tradução em Português

    Directory of Open Access Journals (Sweden)

    Mariana A. Coutinho-Myrrha

    2014-04-01

    Full Text Available Fundamentos: O Duke Activity Status Index (DASI avalia a capacidade funcional de pacientes com doença cardiovascular (DCV, mas não há versão validada em português para doenças cardiovasculares. Objetivos: Traduzir e adaptar culturalmente o DASI para o idioma português do Brasil, e verificar suas propriedades psicométricas na avaliação da capacidade funcional de pacientes com doenças cardiovasculares. Métodos: O DASI foi traduzido para o português, verificado pela retrotradução para o inglês e avaliado por um comitê de especialistas. A versão pré-teste foi avaliada pela primeira vez em 30 indivíduos. As propriedades psicométricas e a correlação com o teste de esforço foram verificadas em um segundo grupo de 67 indivíduos. Uma análise fatorial exploratória foi realizada em todos os 97 pacientes para verificar a validade de construto do DASI. Resultados: O coeficiente de correlação intraclasse para a confiabilidade teste-reteste foi de 0,87 e para a confiabilidade entre avaliadores foi de 0,84. O alfa de Cronbach para consistência interna foi de 0,93. A validade concorrente foi verificada por correlações positivas significativas de pontuações do DASI com o VO2 max (r = 0,51, p < 0,001. A análise fatorial mostrou dois fatores que explicaram 54% da variância total, com o fator 1 responsável por 40 % da variância. A aplicação do DASI requer entre um e três minutos e meio por paciente. Conclusão: A versão brasileira do DASI parece ser um instrumento válido, confiável, rápido e fácil de administrar para avaliar a capacidade funcional em pacientes com doenças cardiovasculares.

  6. Bioassay-Guided Isolation and Identification of Cytotoxic Compounds from <em>Gymnosperma> <em>glutinosum> Leaves

    Directory of Open Access Journals (Sweden)

    Cristina Rodríguez-Padilla

    2012-09-01

    Full Text Available Bioassay-guided fractionation of hexane extracts of<em> Gymnosperma glutinosumem> (Asteraceae leaves, collected in North Mexico, afforded the known compounds hentriacontane (1 and (+-13<em>S>,14<em>R>,15-trihydroxy-<em>ent>-labd-7-ene (2, as well as the new <em>ent>-labdane diterpene (−-13<em>S>,14<em>R>,15-trihydroxy-7-oxo-<em>ent>-labd-8(9-ene (3. In addition, D-glycero-D-galactoheptitol (4 was isolated from the methanolic extract of this plant. Their structures were established on the basis of high-field 1D- and 2D NMR methods supported by HR-MS data. The cytotoxic activity was determined by using the <em>in vitroem> L5178Y-R lymphoma murine model. Hentriacontane (1 and the new <em>ent>-labdane 3 showed weak cytotoxicity, whereas the <em>ent>-labdane 2 showed significant (<em>p> < 0.05 and concentration dependent cytotoxicity (up to 78% against L5178Y-R cells at concentrations ranging from 7.8 to 250 µg/mL.

  7. A preliminary score for the assessment of disease activity in hereditary recurrent fevers : results from the AIDAI (Auto-Inflammatory Diseases Activity Index) Consensus Conference

    NARCIS (Netherlands)

    Piram, Maryam; Frenkel, Joost; Gattorno, Marco; Ozen, Seza; Lachmann, Helen J.; Goldbach-Mansky, Raphaela; Hentgen, Veronique; Neven, Benedicte; Stojanovic, Katia Stankovic; Simon, Anna; Kuemmerle-Deschner, Jasmin; Hoffman, Hal; Stojanov, Silvia; Duquesne, Agnes; Pillet, Pascal; Martini, Alberto; Pouchot, Jacques; Kone-Paut, Isabelle

    2011-01-01

    Background The systemic autoinflammatory disorders (SAID) share many clinical manifestations, albeit with variable patterns, intensity and frequency. A common definition of disease activity would be rational and useful in the management of these lifelong diseases. Moreover, standardised disease acti

  8. A preliminary score for the assessment of disease activity in hereditary recurrent fevers: results from the AIDAI (Auto-Inflammatory Diseases Activity Index) Consensus Conference.

    NARCIS (Netherlands)

    Piram, M.; Frenkel, J.; Gattorno, M.; Ozen, S.; Lachmann, H.J.; Goldbach-Mansky, R.; Hentgen, V.; Neven, B.; Stojanovic, K.S.; Simon, A.; Kuemmerle-Deschner, J.; Hoffman, H.; Stojanov, S.; Duquesne, A.; Pillet, P.; Martini, A.; Pouchot, J.; Kone-Paut, I.

    2011-01-01

    BACKGROUND: The systemic autoinflammatory disorders (SAID) share many clinical manifestations, albeit with variable patterns, intensity and frequency. A common definition of disease activity would be rational and useful in the management of these lifelong diseases. Moreover, standardised disease act

  9. Fingerprinting of music scores

    Science.gov (United States)

    Irons, Jonathan; Schmucker, Martin

    2004-06-01

    Publishers of sheet music are generally reluctant in distributing their content via the Internet. Although online sheet music distribution's advantages are numerous the potential risk of Intellectual Property Rights (IPR) infringement, e.g. illegal online distributions, disables any innovation propensity. While active protection techniques only deter external risk factors, additional technology is necessary to adequately treat further risk factors. For several media types including music scores watermarking technology has been developed, which ebeds information in data by suitable data modifications. Furthermore, fingerprinting or perceptual hasing methods have been developed and are being applied especially for audio. These methods allow the identification of content without prior modifications. In this article we motivate the development of watermarking and fingerprinting technologies for sheet music. Outgoing from potential limitations of watermarking methods we explain why fingerprinting methods are important for sheet music and address potential applications. Finally we introduce a condept for fingerprinting of sheet music.

  10. Assessment of Disease Activity in Small Bowel Crohn’s Disease: Comparison between Endoscopy and Magnetic Resonance Enterography Using MRIA and Modified MRIA Score

    Directory of Open Access Journals (Sweden)

    Arnaldo Scardapane

    2015-01-01

    Full Text Available Objectives. To retrospectively compare the results of the MRIA (magnetic resonance index of activity with a modified MRIA (mMRIA, which was calculated excluding from MRIA formula the data of relative contrast enhancement (RCE. Materials and Methods. MR-E and corresponding endoscopic records of 100 patients were reviewed. MRIA, mMRIA, and SES endoscopic index were calculated for all the patients. Namely, MRIA was calculated as follows: (1.5 × wall thickening + 0.02 × RCE + 5 × intramural edema + 10 × ulcers, while mMRIA was calculated with the modified formula (1.5 × wall thickening + 5 × intramural edema + 10 × ulcers. Results. Mean MRIA and mMRIA values were 19.3 and 17.68, respectively p<0.0001. A significant correlation p<0.0001 was observed between MRIA and mMRIA scores and between both MR indexes and SES p<0.0001. Conclusions. mMRIA was comparable to MRIA in the evaluation of disease activity in Crohn’s disease.

  11. The Apgar Score.

    Science.gov (United States)

    2015-10-01

    The Apgar score provides an accepted and convenient method for reporting the status of the newborn infant immediately after birth and the response to resuscitation if needed. The Apgar score alone cannot be considered as evidence of, or a consequence of, asphyxia; does not predict individual neonatal mortality or neurologic outcome; and should not be used for that purpose. An Apgar score assigned during resuscitation is not equivalent to a score assigned to a spontaneously breathing infant. The American Academy of Pediatrics and the American College of Obstetricians and Gynecologists encourage use of an expanded Apgar score reporting form that accounts for concurrent resuscitative interventions.

  12. Humanized-Single Domain Antibodies (VH/VHH that Bound Specifically to<em> Naja kaouthiaem> Phospholipase A2 and Neutralized the Enzymatic Activity

    Directory of Open Access Journals (Sweden)

    Wanpen Chaicumpa

    2012-07-01

    Full Text Available <em>Naja kaouthiaem> (monocled cobra venom contains many isoforms of secreted phospholipase A2 (sPLA2. The PLA2 exerts several pharmacologic and toxic effects in the snake bitten subject, dependent or independent on the enzymatic activity. <em>N. kaouthiaem> venom appeared in two protein profiles, P3 and P5, after fractionating the venom by ion exchange column chromatography. In this study, phage clones displaying humanized-camel single domain antibodies (VH/VHH that bound specifically to the P3 and P5 were selected from a humanized-camel VH/VHH phage display library. Two phagemid transfected <em>E. coliem> clones (P3-1 and P3-3 produced humanized-VHH, while another clone (P3-7 produced humanized-VH. At the optimal venom:antibody ratio, the VH/VHH purified from the <em>E. coliem> homogenates neutralized PLA2 enzyme activity comparable to the horse immune serum against the <em>N. kaouthiaem> holo-venom. Homology modeling and molecular docking revealed that the VH/VHH covered the areas around the PLA2 catalytic groove and inserted their Complementarity Determining Regions (CDRs into the enzymatic cleft. It is envisaged that the VH/VHH would ameliorate/abrogate the principal toxicity of the venom PLA2 (membrane phospholipid catabolism leading to cellular and subcellular membrane damage which consequently causes hemolysis, hemorrhage, and dermo-/myo-necrosis, if they were used for passive immunotherapy of the cobra bitten victim. The speculation needs further investigations.

  13. Patient activation in Europe: an international comparison of psychometric properties and patients’ scores on the short form Patient Activation Measure (PAM-13)

    NARCIS (Netherlands)

    Rademakers, J.; Terkildsen Maindal, H.; Steinsbekk, A.; Gensichen, J.; Brenk-Franz, K.; Hendriks, M.

    2016-01-01

    Background: To allow better assessment of patients’ individual competencies for self-management, the Patient Activation Measure (PAM) has been developed in the USA. Because the American studies have shown the PAM to be a valuable tool, several European countries have translated the instrument into t

  14. Análise das propriedades psicométricas do American Orthopaedic Foot and Ankle Society Score (Aofas em pacientes com artrite reumatoide: aplicação do modelo Rasch

    Directory of Open Access Journals (Sweden)

    Cristiano Sena da Conceição

    2016-02-01

    Full Text Available Resumo Objetivo: Testar a confiabilidade e a validade do escore Aofas em uma amostra de pacientes com artrite reumatoide. Métodos: A escala foi aplicada a pacientes com artrite reumatoide, duas vezes pelo entrevistador 1 e uma vez pelo entrevistador 2. O Aofas foi submetido a exame de confiabilidade teste-reteste (com 20 indivíduos com artrite reumatoide. As propriedades psicométricas foram investigadas pela análise Rasch em 33 pacientes com artrite reumatoide. Resultados: O coeficiente de correlação intraclasse (CCI foi de 0,90 < CCI < 0,95 (p < 0,001 para a confiabilidade intraexaminador e 0,75 < CCI < 0,91 (p < 0,001 para a confiabilidade interexaminador. O índice de separação dos indivíduos foi de 1,9 e 4,75 para os itens. Isso demonstra que os pacientes se dividiam em três níveis de habilidade e os itens foram divididos em seis níveis de dificuldades. A análise Rasch mostrou que oito itens foram satisfatórios. Foi identificado um item errôneo, que mostrou percentuais acima dos 5% permitidos pelo modelo estatístico. Além disso, o modelo Rasch sugeriu a revisão do item 8 original. Conclusões: Os resultados sugerem que a versão brasileira do Aofas apresenta confiabilidade adequada, validade de constructo e estabilidade de resposta. Esses resultados indicam que a escala de tornozelo-retropé Aofas apresenta um potencial significativo de aplicabilidade clínica em indivíduos com artrite reumatoide. Outros estudos em populações com outras características já estão em andamento.

  15. Relação entre acuidade visual e atividades instrumentais de vida diária em idosos em seguimento ambulatorial Relationship between visual acuity and instrumental activities of daily living of the elderly in clinical segment

    Directory of Open Access Journals (Sweden)

    Sheila de Melo Borges

    2010-06-01

    Full Text Available OBJETIVO: Avaliar a influêrcia da acuidade visual nas atividades instrumentais de vida diária em idosos em seguimento ambulatorial. MÉTODOS: Foram entrevistados, por meio de instrumento próprio, 64 idosos em seguimento ambulatorial num hospital universitário de Campinas/SP. Os sujeitos foram divididos em dois grupos, conforme os valores obtidos na medida da AV: o grupo I, composto pelos idosos com visão normal ou próxima do normal; e o grupo II, formado por aqueles com baixa visão. Foram realizadas correlações bivariadas entre as variáveis, a fim de identificar as seguintes relações entre os grupos de acuidade visual e as atividades instrumentais de vida diária. RESULTADOS: Foram observadas diferenças significativas entre os idosos com visão normal ou próxima do normal (grupo I e aqueles com baixa visão (grupo II, com respeito às variáveis. O grupo II apresentou maior dificuldade do que o grupo I no escore total do instrumento, bem como nas seguintes tarefas: uso do telefone, preparo de refeições, trabalhos manuais, lavar e passar roupa e tomar corretamente os remédios. CONCLUSÃO: Neste estudo, idosos com baixa visão de ambos os sexos apresentam maior dificuldade para realizar as AIVDs do que idosos com visão normal ou próxima do normal.OBJECTIVE: To evaluate the influence of visual acuity in instrumental activities of daily living in elderly patients in follow-up period. METHODS: through own instruments, sixty-four elderly men and women were interviewed in clinical segment at an academic hospital of Campinas/SP. They were then divided into two groups in accordance to the values that were obtained through the measure of the VA: the first group consisted of elderly people with normal vision or close to the normal, and the second group was formed of those with low vision. Bivariate correlations were made between the variables in order to identify the following relations: between groups of visual and instrumental

  16. Carga de trabajo en tres grupos de pacientes de UCI Española según el Nursing Activities Score

    Directory of Open Access Journals (Sweden)

    Francisco Javier Carmona-Monge

    2013-04-01

    Full Text Available Se objetivó valorizar la carga de trabajo al ingreso y al alta en tres grupos de pacientes (síndrome coronario agudo, insuficiencia respiratoria aguda y sepsis en terapia intensiva. Estudio descriptivo, prospectivo, de 27 meses, incluyéndose 563 pacientes, valorando carga de trabajo según Nursing Activities Score. Existieron diferencias significativas en la carga de trabajo al ingreso y en el alta entre los grupos de pacientes, siendo superior en ambos momentos la de pacientes con insuficiencia respiratoria aguda y sepsis frente a pacientes coronarios. Durante los siete primeros días de estancia se mantuvo esta diferencia, desapareciendo a partir del octavo día, equilibrándose la carga de trabajo para los tres grupos. Para conseguir una adecuada dotación de personal es fundamental contar con instrumentos para medir las necesidades de cuidados y conocer la carga de trabajo de los distintos grupos de enfermos que ingresan con mayor frecuencia en las unidades de terapia intensiva.

  17. Aplicação do escore CRIB como preditor de óbito em unidade de terapia intensiva neonatal: uma abordagem ampliada The use of CRIB score as mortality predictor at neonatal intensive care unit: an extended approach

    OpenAIRE

    Nascimento,Luiz Fernando C.; Rosana dos Santos Ramos

    2004-01-01

    OBJETIVOS: avaliar o uso do escore CRIB (Clinical Risk Index for Babies) em todos os recém-nascidos internados em Unidade de Terapia Intensiva Neonatal (UTIN) e comparar seus resultados com peso ao nascer e idade gestacional. MÉTODOS: estudo observacional, envolvendo todos os recém-nascidos internados na UTIN do Hospital Universitário de Taubaté. As variáveis foram escore CRIB, peso ao nascer, idade gestacional, uso de surfactante, cateterização umbilical, asfixia neonatal e óbito. Foram comp...

  18. SCORE - A DESCRIPTION.

    Science.gov (United States)

    SLACK, CHARLES W.

    REINFORCEMENT AND ROLE-REVERSAL TECHNIQUES ARE USED IN THE SCORE PROJECT, A LOW-COST PROGRAM OF DELINQUENCY PREVENTION FOR HARD-CORE TEENAGE STREET CORNER BOYS. COMMITTED TO THE BELIEF THAT THE BOYS HAVE THE POTENTIAL FOR ETHICAL BEHAVIOR, THE SCORE WORKER FOLLOWS B.F. SKINNER'S THEORY OF OPERANT CONDITIONING AND REINFORCES THE DELINQUENT'S GOOD…

  19. An objective fluctuation score for Parkinson's disease.

    Directory of Open Access Journals (Sweden)

    Malcolm K Horne

    Full Text Available Establishing the presence and severity of fluctuations is important in managing Parkinson's Disease yet there is no reliable, objective means of doing this. In this study we have evaluated a Fluctuation Score derived from variations in dyskinesia and bradykinesia scores produced by an accelerometry based system.The Fluctuation Score was produced by summing the interquartile range of bradykinesia scores and dyskinesia scores produced every 2 minutes between 0900-1800 for at least 6 days by the accelerometry based system and expressing it as an algorithm.This Score could distinguish between fluctuating and non-fluctuating patients with high sensitivity and selectivity and was significant lower following activation of deep brain stimulators. The scores following deep brain stimulation lay in a band just above the score separating fluctuators from non-fluctuators, suggesting a range representing adequate motor control. When compared with control subjects the score of newly diagnosed patients show a loss of fluctuation with onset of PD. The score was calculated in subjects whose duration of disease was known and this showed that newly diagnosed patients soon develop higher scores which either fall under or within the range representing adequate motor control or instead go on to develop more severe fluctuations.The Fluctuation Score described here promises to be a useful tool for identifying patients whose fluctuations are progressing and may require therapeutic changes. It also shows promise as a useful research tool. Further studies are required to more accurately identify therapeutic targets and ranges.

  20. Estuarine morphometry governs optically active substances, <em>K>d(PAR) and beam attenuation

    DEFF Research Database (Denmark)

    Lund-Hansen, L. C.; Nielsen, J. M.; Blüthgen, J.;

    2013-01-01

    Data on optical properties such as diffuse attenuation coefficient Kd(PAR), beam attenuation coefficient (cp) and the optically active constituents (OACs) CDOM, Chl-a and suspended particulate matter were obtained in a Danish temperate coastal plain estuary (56°N) and a Vietnamese tropical ria (12...... this spatial distribution. Partition and multiple regression analyses showed that Chl-a governed Kd(PAR) and beam attenuation coefficient in both estuaries. Significant, high correlations were obtained by multiple regression analyses in the estimation of Kd(PAR) and beam attenuation coefficients in the two...

  1. Promoting an active form of learning out-of-class via answering online “study questions” leads to higher than expected exam scores in General Biology

    Directory of Open Access Journals (Sweden)

    Susan I. Gibson

    2015-10-01

    Full Text Available A rising need for workers in science, technology, engineering and mathematics (STEM fields has fueled interest in improving teaching within STEM disciplines. Numerous studies have demonstrated the benefits of active learning approaches on student learning outcomes. However, many of these studies have been conducted in experimental, rather than real-life class, settings. In addition, most of these studies have focused on in-class active learning exercises. This study tested the effects of answering questions outside of class on exam performance for General Biology students at the University of Minnesota. An online database of 1,020 multiple-choice questions covering material from the first half of the course was generated. Students in seven course sections (with an average of ∼265 students per section were given unlimited access to the online study questions. These students made extensive use of the online questions, with students answering an average of 1,323 questions covering material from the half of the semester for which the questions were available. After students answered a set of questions, they were shown the correct answers for those questions. More specific feedback describing how to arrive at the correct answer was provided for the 73% of the questions for which the correct answers were not deemed to be self-explanatory. The extent to which access to the online study questions improved student learning outcomes was assessed by comparing the performance on exam questions of students in the seven course sections with access to the online study questions with the performance of students in course sections without access to the online study questions. Student performance was analyzed for a total of 89 different exams questions that were not included in the study questions, but that covered the same material covered by the study questions. Each of these 89 questions was used on one to five exams given to students in course sections that

  2. Comparação entre dois escores de prognóstico (PRISM e PIM em unidade de terapia intensiva pediátrica Comparison of two prognostic scores (PRISM and PIM at a pediatric intensive care unit

    Directory of Open Access Journals (Sweden)

    Vanessa Feller Martha

    2005-06-01

    Full Text Available OBJETIVO: Comparar o desempenho do PRISM (Pediatric Risk of Mortality e o PIM (Pediatric Index of Mortality em uma unidade de terapia intensiva pediátrica geral investigando a relação existente entre a mortalidade e a sobrevivência observadas com a mortalidade e sobrevivência estimadas pelos dois escores. MÉTODOS: Estudo de coorte contemporâneo realizado entre 1° de junho de 1999 a 31 de maio de 2000 na unidade de terapia intensiva pediátrica do Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul. Os critérios de inclusão no estudo e o cálculo do PRISM e do PIM foram feitos conforme preconizado e utilizando as fórmulas de seus artigos originais. Para estatística, utilizou-se o teste z de Flora, teste de ajuste de Hosmer-Lemeshow, área sob a curva típica de um recebedor operador de características (curva ROC e teste de correlação de Spearman. O estudo foi aprovado pelo Comitê da instituição. RESULTADOS: Internaram na unidade de terapia intensiva pediátrica 498 pacientes, sendo 77 excluídos. Dos 421 pacientes estudados, 33 (7,83% foram a óbito. A mortalidade estimada pelo PRISM foi de 30,84 (7,22%, com standardized mortality rate 1,07 (0,74-1,50, z = -0,45. Pelo PIM, foi de 26,13 (6,21%, com standardized mortality rate 1,26 (0,87-1,77, z = -1,14. O teste de ajuste de Hosmer-Lemeshow obteve um qui-quadrado 9,23 (p = 0,100 para o PRISM e 27,986 (p OBJECTIVE: To compare the performance of the PRISM (Pediatric Risk of Mortality and the PIM (Pediatric Index of Mortality scores at a general pediatric intensive care unit, investigating the relation between observed mortality and survival and predicted mortality and survival. METHODS: A contemporary cohort study undertaken between 1 June 1999 and 31 May 2000 at the Pontifícia Universidade Católica do Rio Grande do Sul, Hospital São Lucas pediatric intensive care unit. The inclusion criteria and the PRISM and PIM calculations were performed as set out

  3. <em>Plasmodium bergheiem> ANKA: erythropoietin activates neural stem cells in an experimental cerebral malaria model

    DEFF Research Database (Denmark)

    Core, Andrew; Hempel, Casper; Kurtzhals, Jørgen A L;

    2011-01-01

    Cerebral malaria (CM) causes substantial mortality and neurological sequelae in survivors, and no neuroprotective regimens are currently available for this condition. Erythropoietin (EPO) reduces neuropathology and improves survival in murine CM. Using the Plasmodium berghei model of CM, we...... investigated if EPO's neuroprotective effects include activation of endogenous neural stem cells (NSC). By using immunohistochemical markers of different NSC maturation stages, we show that EPO increased the number of nestin(+) cells in the dentate gyrus and in the sub-ventricular zone of the lateral...... ventricles, relative to control-treatment. 75% of the EPO-treated CM mice displayed migration as nestin(+) NSC. The NSC showed differentiation towards a neural cell lineage as shown by PSA-NCAM binding and NSC maturation and lineage commitment was significantly affected by exogenous EPO and by CM in the sub...

  4. Relationship between the climbing up and climbing down stairs domain scores on the FES-DMD, the score on the Vignos Scale, age and timed performance of functional activities in boys with Duchenne muscular dystrophy

    Directory of Open Access Journals (Sweden)

    Lilian A. Y. Fernandes

    2014-12-01

    Full Text Available BACKGROUND: Knowing the potential for and limitations of information generated using different evaluation instruments favors the development of more accurate functional diagnoses and therapeutic decision-making. OBJECTIVE: To investigate the relationship between the number of compensatory movements when climbing up and going down stairs, age, functional classification and time taken to perform a tested activity (TA of going up and down stairs in boys with Duchenne muscular dystrophy (DMD. METHOD: A bank of movies featuring 30 boys with DMD performing functional activities was evaluated. Compensatory movements were assessed using the climbing up and going down stairs domain of the Functional Evaluation Scale for Duchenne Muscular Dystrophy (FES-DMD; age in years; functional classification using the Vignos Scale (VS, and TA using a timer. Statistical analyses were performed using the Spearman correlation test. RESULTS: There is a moderate relationship between the climbing up stairs domain of the FES-DMD and age (r=0.53, p=0.004 and strong relationships with VS (r=0.72, p=0.001 and TA for this task (r=0.83, p<0.001. There were weak relationships between the going down stairs domain of the FES-DMD-going down stairs with age (r=0.40, p=0.032, VS (r=0.65, p=0.002 and TA for this task (r=0.40, p=0.034. CONCLUSION: These findings indicate that the evaluation of compensatory movements used when climbing up stairs can provide more relevant information about the evolution of the disease, although the activity of going down stairs should be investigated, with the aim of enriching guidance and strengthening accident prevention. Data from the FES-DMD, age, VS and TA can be used in a complementary way to formulate functional diagnoses. Longitudinal studies and with broader age groups may supplement this information.

  5. The Bandim tuberculosis score

    DEFF Research Database (Denmark)

    Rudolf, Frauke; Joaquim, Luis Carlos; Vieira, Cesaltina

    2013-01-01

    Background: This study was carried out in Guinea-Bissau ’ s capital Bissau among inpatients and outpatients attending for tuberculosis (TB) treatment within the study area of the Bandim Health Project, a Health and Demographic Surveillance Site. Our aim was to assess the variability between 2...... physicians in performing the Bandim tuberculosis score (TBscore), a clinical severity score for pulmonary TB (PTB), and to compare it to the Karnofsky performance score (KPS). Method : From December 2008 to July 2009 we assessed the TBscore and the KPS of 100 PTB patients at inclusion in the TB cohort and...

  6. Prática de atividade física em adolescentes brasileiros Physical activity practice among brazilian adolescents

    Directory of Open Access Journals (Sweden)

    Pedro Curi Hallal

    2010-10-01

    Full Text Available O objetivo deste estudo é descrever a prática de atividade física em adolescentes, utilizando dados da Pesquisa Nacional de Saúde do Escolar (PeNSE, coletados em todas as capitais do Brasil e no Distrito Federal em 2009. A amostra incluiu escolares do 9º ano do ensino fundamental (n=60.973. Foram investigadas a prática de atividade física nos últimos sete dias, incluindo modo de deslocamento para a escola, prática de atividade física dentro e fora da escola e participação nas aulas de educação física. Consideraram-se ativos os jovens que acumularam > 300 min/sem de atividade física. A proporção de ativos foi de 43,1%, sendo maior nos meninos (56,2% em comparação às meninas (31,3%. Metade dos adolescentes (49,2% relatou ter tido duas ou mais aulas de educação física na semana anterior à entrevista; 79,2% relataram assistir a duas horas diárias de televisão ou mais. Os dados do PeNSE indicam baixa prevalência de jovens ativos e com duas ou mais aulas de educação física por semana, além de elevada prevalência de comportamento sedentário. Tais dados podem ser utilizados como linha de base para o monitoramento de atividade física em escolares brasileiros, mas desde já sugerem a necessidade de intervenções para a promoção de atividade física em adolescentes brasileiros.The aim of this study is to describe physical activity practice among Brazilian adolescents by using data from the National Adolescent School-based Health Survey (PeNSE collected in all state capitals and the Federal District in 2009. The sample included students of the ninth year (n=60,973. It was investigated the physical activity practice seven days prior to the interview, including transportation mode, physical activity practice inside and outside the school and participation in Physical Education classes. Adolescents were classified as active if performing > 300 min/wk of physical activity. The proportion of active adolescents was 43

  7. Volleyball Scoring Systems.

    Science.gov (United States)

    Calhoun, William; Dargahi-Noubary, G. R.; Shi, Yixun

    2002-01-01

    The widespread interest in sports in our culture provides an excellent opportunity to catch students' attention in mathematics and statistics classes. One mathematically interesting aspect of volleyball, which can be used to motivate students, is the scoring system. (MM)

  8. Numerical Tsunami Hazard Assessment of the Only Active Lesser Antilles Arc Submarine Volcano: Kick 'em Jenny.

    Science.gov (United States)

    Dondin, F. J. Y.; Dorville, J. F. M.; Robertson, R. E. A.

    2015-12-01

    The Lesser Antilles Volcanic Arc has potentially been hit by prehistorical regional tsunamis generated by voluminous volcanic landslides (volume > 1 km3) among the 53 events recognized so far. No field evidence of these tsunamis are found in the vincity of the sources. Such a scenario taking place nowadays would trigger hazardous tsunami waves bearing potentially catastrophic consequences for the closest islands and regional offshore oil platforms.Here we applied a complete hazard assessment method on the only active submarine volcano of the arc Kick 'em Jenny (KeJ). KeJ is the southernmost edifice with recognized associated volcanic landslide deposits. From the three identified landslide episodes one is associated with a collapse volume ca. 4.4 km3. Numerical simulations considering a single pulse collapse revealed that this episode would have produced a regional tsunami. An edifice current volume estimate is ca. 1.5 km3.Previous study exists in relationship to assessment of regional tsunami hazard related to shoreline surface elevation (run-up) in the case of a potential flank collapse scenario at KeJ. However this assessment was based on inferred volume of collapse material. We aim to firstly quantify potential initial volumes of collapse material using relative slope instability analysis (RSIA); secondly to assess first order run-ups and maximum inland inundation distance for Barbados and Trinidad and Tobago, i.e. two important economic centers of the Lesser Antilles. In this framework we present for seven geomechanical models tested in the RSIA step maps of critical failure surface associated with factor of stability (Fs) for twelve sectors of 30° each; then we introduce maps of expected potential run-ups (run-up × the probability of failure at a sector) at the shoreline.The RSIA evaluates critical potential failure surface associated with Fs sources characteristics are retrieved from numerical simulation using an hydraulic equations-based code (Volc

  9. Genotoxicity of <em>Euphorbia hirtaem>: An <em>Allium cepaem> Assay

    Directory of Open Access Journals (Sweden)

    Kwan Yuet Ping

    2012-06-01

    Full Text Available The potential genotoxic effects of methanolic extracts of <em>Euphorbia hirta em>which is commonly used in traditional medicine to treat a variety of diseased conditions including asthma, coughs, diarrhea and dysentery was investigated using <em>Allium cepaem> assay. The extracts of 125, 250, 500 and 1,000 µg/mL were tested on root meristems of <em>A. cepaem>. Ethylmethanesulfonate was used as positive control and distilled water was used as negative control. The result showed that mitotic index decreased as the concentrations of <em>E. hirtaem> extract increased. A dose-dependent increase of chromosome aberrations was also observed. Abnormalities scored were stickiness, c-mitosis, bridges and vagrant chromosomes. Micronucleated cells were also observed at interphase. Result of this study confirmed that the methanol extracts of <em>E. hirta em>exerted significant genotoxic and mitodepressive effects at 1,000 µg/mL.

  10. Increasing Active Student Responding in a University Applied Behavior Analysis Course: The Effect of Daily Assessment and Response Cards on End of Week Quiz Scores

    Science.gov (United States)

    Malanga, Paul R.; Sweeney, William J.

    2008-01-01

    The study compared the effects of daily assessment and response cards on average weekly quiz scores in an introduction to applied behavior analysis course. An alternating treatments design (Kazdin 1982, "Single-case research designs." New York: Oxford University Press; Cooper et al. 2007, "Applied behavior analysis." Upper Saddle River:…

  11. The macrophage activation marker sCD163 combined with markers of the Enhanced Liver Fibrosis (ELF) score predicts clinically significant portal hypertension in patients with cirrhosis

    DEFF Research Database (Denmark)

    Sandahl, T D; McGrail, R; Møller, Holger Jon;

    2016-01-01

    BACKGROUND: Noninvasive identification of significant portal hypertension in patients with cirrhosis is needed in hepatology practice. AIM: To investigate whether the combination of sCD163 as a hepatic inflammation marker and the fibrosis markers of the Enhanced Liver Fibrosis score (ELF) can pre...

  12. <em>Rhinacanthus nasutusem> Extracts Prevent Glutamate and Amyloid-β Neurotoxicity in HT-22 Mouse Hippocampal Cells: Possible Active Compounds Include Lupeol, Stigmasterol and β-Sitosterol

    Directory of Open Access Journals (Sweden)

    James M. Brimson

    2012-04-01

    Full Text Available The Herb <em>Rhinacanthus nasutusem> (L. Kurz, which is native to Thailand and Southeast Asia, has become known for its antioxidant properties. Neuronal loss in a number of diseases including Alzheimer’s disease is thought to result, in part, from oxidative stress. Glutamate causes cell death in the mouse hippocampal cell line, HT-22, by unbalancing redox homeostasis, brought about by a reduction in glutathione levels, and amyloid-β has been shown to induce reactive oxygen species (ROS production. Here in, we show that ethanol extracts of <em>R. nasutusem> leaf and root are capable of dose dependently attenuating the neuron cell death caused by both glutamate and amyloid-β treatment. We used free radical scavenging assays to measure the extracts antioxidant activities and as well as quantifying phenolic, flavonoid and sterol content. Molecules found in <em>R. nasutusem>, lupeol, stigmasterol and β-sitosterol are protective against glutamate toxicity.

  13. Periódicos em ciências agrárias: análise bibliométrica utilizando o Article Influence Score do Institute for Scientific Information

    OpenAIRE

    Gibrowski, Cristina

    2012-01-01

    This article presents a bibliometrical analysis held in the field of Agricultural Science in the subdivisions of Agronomy, Multidisciplinary Agronomy, Political and Economical Agronomy, Science of Soil, Agricultural Engineering and Horticulture. This paper uses the Article Influence Score of the Institute for Scientific Information published in the “Journal Citation Reports” in 2009, as the parameter to define the titles of the most important periodical with the goal of identifying which maga...

  14. Routine Assessment of Patient Index Data 3 score (RAPID3) correlates well with Bath Ankylosing Spondylitis Disease Activity index (BASDAI) in the assessment of disease activity and monitoring progression of axial spondyloarthritis.

    Science.gov (United States)

    Danve, Abhijeet; Reddy, Anusha; Vakil-Gilani, Kiana; Garg, Neha; Dinno, Alexis; Deodhar, Atul

    2015-01-01

    Routine Assessment of Patient Index Data 3 (RAPID3) is a composite index, very useful for assessment of disease activity of various rheumatic diseases including RA. If RAPID3 can also reliably measure disease activity in axial spondyloarthritis (axSpA), it may prove to be a practical and effective quantitative assessment tool in busy practices. We studied the association of RAPID3 with Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Patients with Ankylosing Spondylitis (AS) seen from 2007 to 2012 were classified as having AS or non-radiographic axial spondyloarthritis (nr-axSpA) using modified New York criteria and Assessment of SpondyloArthritis International Society criteria, respectively. Patients with simultaneous BASDAI and RAPID3 scores were enrolled (N = 112; 105 with AS, seven with nr-axSpA). Multiple regression and nonparametric receiver operating characteristics were used. Baseline mean (SD) BASDAI and RAPID3 were 4.2 (2.5) and 3.8 (2.3), respectively. Multiple linear regressions modeled a quadratic relationship between BASDAI and RAPID3 for 321 observations in 112 patients with axSpA (1) cross-sectionally: BASDAI predicted by RAPID3 (β = 1.171; s.e. = 0.113, p < 0.001) and RAPID3(2) (β = -0.037; s.e. = 0.014, p = 0.011) with an adjusted R (2) of 0.676; and (2) longitudinally: BASDAI predicted by RAPID3 (β = 1.196; s.e. = 0.111, p < 0.001), RAPID3(2) (β = -0.042; s.e. = 0.014, p = 0.004), and visit number (β = -0.142; s.e. = 0.038, p < 0.001) with an adjusted R (2) of 0.689. RAPID3 (correctly classified) corresponded to BASDAI scores of 2, 4, and 6: 1.40 (85.8 %), 3.33 (81.9 %), and 5.43 (87.1 %), respectively. RAPID3 correlates well with BASDAI in monitoring axSpA patients (including AS) in cross-sectional and longitudinal follow-up. Since it also correlates with measures of disease activity of other rheumatic diseases including RA, RAPID3 could be an attractive measure

  15. Efeitos ambientais e genéticos sobre peso, perímetro escrotal e escores de avaliação visual à desmama em bovinos da raça Canchim Environmental and genetic effects on weight, scrotal circumference and visual scores at weaning on Canchim beef cattle

    Directory of Open Access Journals (Sweden)

    Fabiana Barichello

    2011-02-01

    Full Text Available Os efeitos de ano e época de nascimento, propriedade, sexo do bezerro, regime alimentar, idade do bezerro e idade da vaca ao parto, os efeitos aditivos direto e materno da raça Charolesa e o efeito de heterose materna entre as raças Charolesa e zebu foram avaliados pelo método dos quadrados míninos sobre características de importância econômica, como peso, perímetro escrotal e escores visuais de conformação frigorífica, de umbigo e de pelame à desmama em bovinos da raça Canchim. Utilizaram-se dados de 12.334 animais Canchim nascidos de 1999 a 2005. O ano e a época de nascimento, a propriedade, o regime alimentar e a idade da vaca ao parto (linear e quadrático tiveram efeitos significativos sobre todas as características estudadas. Houve efeitos do sexo sobre o peso do bezerro à desmama e o escore de umbigo; da idade do bezerro sobre peso, perímetro escrotal e escores de conformação frigorífica e de pelame; e das proporções de Charolês no bezerro e na mãe sobre o peso, a conformação frigorífica e a qualidade de pelagem; e da heterozigose materna sobre peso, perímetro escrotal e escores de conformação frigorífica e de umbigo. Os efeitos aditivos diretos da raça Charolesa como desvio do zebu foram negativos sobre peso, conformação frigorífica e qualidade da pelagem à demama, enquanto os efeitos aditivos maternos foram positivos. Os efeitos heteróticos maternos foram positivos sobre peso, perímetro escrotal e escores de conformação frigorífica e de umbigo. Em geral, essas fontes de variação devem ser consideradas nas estimativas de parâmetros genéticos e nas avaliações genéticas dos animais Canchim para as características estudadas.The effects of calving year and season, property, sex of the calf, feeding regime, age of calf and age of dam at calving, maternal and direct additive effects of Charolais breed, and maternal heterosis effects among Charolais and zebu breeds were evaluated by the method

  16. Instant MuseScore

    CERN Document Server

    Shinn, Maxwell

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. Instant MuseScore is written in an easy-to follow format, packed with illustrations that will help you get started with this music composition software.This book is for musicians who would like to learn how to notate music digitally with MuseScore. Readers should already have some knowledge about musical terminology; however, no prior experience with music notation software is necessary.

  17. Validade e equivalência da versão em português do Veterans Specific Activity Questionnaire

    Directory of Open Access Journals (Sweden)

    Geraldo de Albuquerque Maranhão-Neto

    2011-08-01

    Full Text Available FUNDAMENTO: O Veterans Specific Activity Questionnaire (VSAQ tem sido utilizado para a individualização de testes ergométricos (TE e para avaliar indiretamente a aptidão cardiorrespiratória (ACR em estudos epidemiológicos. Apesar disso, ainda não há versão em português validada. OBJETIVO: Verificar a validade de critério da versão em português do VSAQ e examinar a equivalência de mensuração dessa versão em 95 indivíduos, sendo 8 mulheres (69 ± 7 anos, com indicação para a realização de TE. MÉTODOS: Os indivíduos realizaram teste cardiopulmonar de exercício progressivo máximo em ciclo-ergômetro. A correlação do escore do VSAQ com o MET Máximo Medido e Estimado foi comparada com os resultados de outros estudos. O Nomograma VSAQ foi calculado e seus resultados comparados com os valores reais da ACR por regressão linear. Limites de concordância e as diferenças médias (vieses foram avaliados segundo a metodologia proposta por Bland e Altman. RESULTADOS: Os escores obtidos através do VSAQ correlacionaram-se de forma significativa com o MET máximo medido (r = 0,64 e estimado (r = 0,67, resultados equivalentes àqueles obtidos com versões originais. O nomograma VSAQ obteve resultados com R múltiplo de 0,78 (para MET medido e 0,80 (para MET estimado. O nomograma, entretanto, parece subestimar os valores de indivíduos com ACR acima de 6 MET. CONCLUSÃO: A versão do VSAQ confirmou-se válida e equivalente à versão original, especialmente para avaliação de indivíduos cardiopatas e de idade avançada.

  18. Developing Scoring Algorithms

    Science.gov (United States)

    We developed scoring procedures to convert screener responses to estimates of individual dietary intake for fruits and vegetables, dairy, added sugars, whole grains, fiber, and calcium using the What We Eat in America 24-hour dietary recall data from the 2003-2006 NHANES.

  19. Tensorial Orientation Scores

    NARCIS (Netherlands)

    van de Gronde, Jasper J.; Azzopardi, George; Petkov, Nicolai

    2015-01-01

    Orientation scores are representations of images built using filters that only select on orientation (and not on the magnitude of the frequency). Importantly, they allow (easy) reconstruction, making them ideal for use in a filtering pipeline. Traditionally a specific set of orientations has to be c

  20. The lod score method.

    Science.gov (United States)

    Rice, J P; Saccone, N L; Corbett, J

    2001-01-01

    The lod score method originated in a seminal article by Newton Morton in 1955. The method is broadly concerned with issues of power and the posterior probability of linkage, ensuring that a reported linkage has a high probability of being a true linkage. In addition, the method is sequential, so that pedigrees or lod curves may be combined from published reports to pool data for analysis. This approach has been remarkably successful for 50 years in identifying disease genes for Mendelian disorders. After discussing these issues, we consider the situation for complex disorders, where the maximum lod score (MLS) statistic shares some of the advantages of the traditional lod score approach but is limited by unknown power and the lack of sharing of the primary data needed to optimally combine analytic results. We may still learn from the lod score method as we explore new methods in molecular biology and genetic analysis to utilize the complete human DNA sequence and the cataloging of all human genes.

  1. Atividade física e qualidade de vida em mulheres com 60 anos ou mais: fatores associados Physical activity and quality of life in women aged 60 or older: associated factors

    Directory of Open Access Journals (Sweden)

    Euller Duarte de Carvalho

    2010-09-01

    a boa autopercepção da saúde aumentou o escore de qualidade de vida em 7,3 pontos; o uso de maior número de medicamentos diminuiu em 4,4 pontos; e a prática de exercícios físicos moderados ou vigorosos aumentou em 4,8 pontos o referido escore. CONCLUSÕES: as mulheres despendem muito tempo na posição sentada. Evidenciou-se a importância da prática de exercícios físicos de intensidade moderada/vigorosa contribuindo para a obtenção de uma boa qualidade de vida.PURPOSE: to evaluate the level of physical activity, quality of life and associated factors in women aged 60 or older. METHODS: a cross-sectional study was conducted on 271 women who go to a Leisure Center and women attended at a menopause ambulatory in Campinas (SP. The women were invited to take part in the research, carried out through interviews. The instruments used were the version 8 of the International Physical Activity Questionnaire (IPAQ modified for the elderly population in order to evaluate their physical activity, and the World Health Organization Questionnaire of Quality of Life specific for this group (WHOQOL-OLD to evaluate their quality of life. IPAQ results were assessed using tertiles. The association between the WHOQOL-OLD and the IPAQ results and subject characteristics was assessed by the Student's t test, Mann-Whitney test and multiple analyses. RESULTS: the average age of women was 67.4±5.3 years. Among these women, 33% were classified as being less active. Analysis of each physical activity domain showed that 60.8% of the time was spent in sitting activities (1,701.6±986.1 minutes/week. Multiple analyses indicated that attending a leisure center in Campinas (SP and being 70 years old or older increased the chances of engaging in moderate-intensity or vigorous-intensity physical activity by 11.4 and 2.8 times, respectively. The average quality of life score was 66.9±11.7. The highest value was observed in the domain related to sensory abilities (72.0±18.8 and the

  2. Condição corporal, variação de peso e desempenho reprodutivo de vacas de cria em pastagem nativa no Pantanal Body condition score, weight variation and reproductive performance of beef cows in rangelands from the Pantanal region

    Directory of Open Access Journals (Sweden)

    Sandra Aparecida Santos

    2009-02-01

    Full Text Available Objetivou-se avaliar a influência do escore de condição corporal (ECC sobre a eficiência reprodutiva de vacas de cria nos períodos pré e pós-parto e a probabilidade de parição, usando o escore de condição corporal e a variação ponderal no período crítico do ciclo reprodutivo. Utilizaram-se 248 vacas multíparas mantidas em pastagens nativas distribuídas em quatro estratégias de suplementação: mistura mineral (controle; suplemento farelado; suplemento líquido; suplemento líquido para vacas e bezerros. As avaliações de peso e ECC, na escala de 1 a 9, foram realizadas no período crítico: em agosto (período pré-parto, 60-90 dias antes da parição e em janeiro (período pós-parto e reprodutivo durante quatro anos consecutivos. Para a análise dos anos consecutivos de reprodução, criou-se um escore de reprodução, ou seja, somou-se o número de parições de cada vaca durante os quatro anos pecuários avaliados. O escore de condição corporal nos períodos pré e pós-parto e a idade da vaca influenciaram o escore de reprodução. Portanto, para avaliação da probabilidade de parição, foram utilizadas todas as vacas, classificadas em paridas e vazias. Utilizando equações de estimação generalizadas (EEG, foi modelada a probabilidade de as matrizes serem classificadas como paridas considerando variáveis exploratórias ao longo do tempo. Para se obter probabilidade de parição superior a 80%, as vacas devem possuir escore de aproximadamente 5,5 no período pré-parto. Aproximadamente 60% das vacas paridas mantiveram ou ganharam peso no período crítico do ano, o que levou a maior probabilidade de reconcepção, similar ao observado para as vacas vazias, porém com probabilidade menor de parição. O período pré-parto é o melhor para estimar a probabilidade de parição das vacas por meio da avaliação do escore corporal. A seleção de vacas adaptadas às condições bioclimáticas do Pantanal aumenta a

  3. Automated Essay Scoring

    Directory of Open Access Journals (Sweden)

    Semire DIKLI

    2006-01-01

    Full Text Available Automated Essay Scoring Semire DIKLI Florida State University Tallahassee, FL, USA ABSTRACT The impacts of computers on writing have been widely studied for three decades. Even basic computers functions, i.e. word processing, have been of great assistance to writers in modifying their essays. The research on Automated Essay Scoring (AES has revealed that computers have the capacity to function as a more effective cognitive tool (Attali, 2004. AES is defined as the computer technology that evaluates and scores the written prose (Shermis & Barrera, 2002; Shermis & Burstein, 2003; Shermis, Raymat, & Barrera, 2003. Revision and feedback are essential aspects of the writing process. Students need to receive feedback in order to increase their writing quality. However, responding to student papers can be a burden for teachers. Particularly if they have large number of students and if they assign frequent writing assignments, providing individual feedback to student essays might be quite time consuming. AES systems can be very useful because they can provide the student with a score as well as feedback within seconds (Page, 2003. Four types of AES systems, which are widely used by testing companies, universities, and public schools: Project Essay Grader (PEG, Intelligent Essay Assessor (IEA, E-rater, and IntelliMetric. AES is a developing technology. Many AES systems are used to overcome time, cost, and generalizability issues in writing assessment. The accuracy and reliability of these systems have been proven to be high. The search for excellence in machine scoring of essays is continuing and numerous studies are being conducted to improve the effectiveness of the AES systems.

  4. Correlação dos índices de atividade da artrite reumatoide (Disease Activity Score 28 medidos com VHS, PCR, Simplified Disease Activity Index e Clinical Disease Activity Index e concordância dos estados de atividade da doença com vários pontos de corte numa população do nordeste brasileiro

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    Marta Maria das Chagas Medeiros

    2015-12-01

    Full Text Available Resumo Introdução: O Disease Activity Score 28 (DAS28 e versões têm sido usados para medir atividade da artrite reumatoide (AR, mas não existe consenso sobre qual é o melhor. Objetivos: Determinar a correlação entre os índices (DAS28 VHS, DAS28 PCR, SDAI e CDAI e avaliar a concordância dos estratos de atividade com o uso de diferentes pontos de corte. Métodos: Pacientes com artrite reumatoide foram avaliados transversalmente com coleta de dados para cálculo do DAS28 (VHS e PCR, SDAI e CDAI, com o uso de pontos de cortes diferentes para definição de remissão, atividade leve, moderada e alta. Correlações de Pearson foram calculadas para medidas contínuas e concordância (teste de kappa para os estratos (remissão, atividade leve, moderada e alta. Resultados: De 111 pacientes incluídos, 108 foram mulheres, média de 55,6 anos, tempo de doença de 11 anos. DAS28 (VHS foi significantemente maior do que DAS28 (PCR (4 vs. 3,5; p < 0,001 e os valores permaneceram maiores após estratificação por idade, sexo, tempo doença, fator reumatoide e HAQ. Correlações entre índices variaram de 0,84 a 0,99, com melhor correlação entre SDAI e CDAI. Concordâncias entre estratos de atividade variaram de 46,8% a 95,8%. DAS28 (PCR com ponto de corte para remissão de 2,3 subestimou atividade da doença em 45,8% quando comparado com DAS28 (VHS. SDAI e CDAI apresentaram concordância de 95,8%. Os quatro índices mostraram associação com tempo de doença e HAQ. Conclusões: Embora os índices de atividade apresentem boa correlação, mostram discrepâncias nos estratos de atividade. Tornam-se necessários mais estudos para definir melhor índice e melhores pontos de corte.

  5. <em>An entem>-Kaurane-Type Diterpene in <em>Croton antisyphiliticusem> Mart.

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    Ana Maria Pereira

    2012-07-01

    Full Text Available <em>Croton antisyphiliticus em>is a medicinal plant widely used in the treatment of microbial infections, especially those affecting the genital tract. Crude extract, fractions and pure compound isolated from roots of this species were investigated to validate their antimicrobial activity against <em>Escherichia coliem> and <em>Staphylococcus aureusem>. The compound <em>ent>-kaur-16-en-18-oic acid was isolated as a major component (0.7% of crude extract, and its MIC value determined against <em>S. aureusem> (ATCC 6538 was 250 μg/mL. This is the first phytochemical work on the species monitored with antimicrobial assay.

  6. Risk factors for sternal wound infections and application of the STS score in coronary artery bypass graft surgery Fatores de risco para infecção de ferida esternal e aplicação do escore da STS em pacientes submetidos à cirurgia de revascularização miocárdica

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    Pedro Silvio Farsky

    2011-12-01

    Full Text Available BACKGROUND: Sternal wound infection (SWI after coronary artery bypass graft (CABG surgery is a major complication. Identifying patients at risk of SWI is essential for the application of preventive measures. OBJECTIVE: To identify the pre- and intra-operative risk factors, apply the STS risk score and determine the correlation between the risk score and microorganisms isolated from surgical wounds in a Brazilian hospital. METHODS: This is a retrospective analysis of a database of all CABG surgeries performed in a single institution from 2006 to 2008. Chi-square analysis was used for categorical variables and Student's t-test was used for quantitative variables. Multivariate logistic regression model was used to identify independent risk factors for SWI. P 40 kg/m² (OR 6.27, 95%CI 2.53-15.48; P40 kg/m², number of affected coronary arteries and use of bilateral internal thoracic artery were associated with a higher risk of infection. The STS risk score can be successfully used and there was no correlation between microorganisms, the score and risk factors at our institution.FUNDAMENTO: A infecção de ferida operatória esternal após cirurgia de revascularização miocárdica (CRM é uma grave complicação. Identificar pacientes com risco elevado é fundamental para introdução de medidas de preventivas. OBJETIVO: Identificar os fatores de risco pré e intra-operatórios, avaliar o escore de risco da STS e correlação entre o escore e os microorganismos isolados em ferida operatória em hospital brasileiro. MÉTODOS: Análise retrospectiva de um banco de dados prospectivamente coletado de todas as CRM realizadas em centro único, no período de 2006 a 2008. Teste do qui-quadrado foi utilizado para variáveis categóricas e teste t-Student, para variáveis quantitativas. Modelo multivariado por regressão logística foi utilizado para identificação de fatores de risco independente para infecção de ferida esternal. P40 kg/m² (OR 5,38; IC

  7. New Trifluoromethyl Triazolopyrimidines as Anti-<em>Plasmodium> <em>falciparum> Agents

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    Núbia Boechat

    2012-07-01

    Full Text Available According to the World Health Organization, half of the World’s population, approximately 3.3 billion people, is at risk for developing malaria. Nearly 700,000 deaths each year are associated with the disease. Control of the disease in humans still relies on chemotherapy. Drug resistance is a limiting factor, and the search for new drugs is important. We have designed and synthesized new 2-(trifluoromethyl[1,2,4]triazolo[1,5-<em>a>]pyrimidine derivatives based on bioisosteric replacement of functional groups on the anti-malarial compounds mefloquine and amodiaquine. This approach enabled us to investigate the impact of: (i ring bioisosteric replacement; (ii a CF3 group substituted at the 2-position of the [1,2,4]triazolo[1,5-<em>a>]pyrimidine scaffold and (iii a range of amines as substituents at the 7-position of the of heterocyclic ring; on <em>in vitroem> activity against <em>Plasmodium falciparumem>. According to docking simulations, the synthesized compounds are able to interact with <em>P. falciparumem> dihydroorotate dehydrogenase (<em>Pf>DHODH through strong hydrogen bonds. The presence of a trifluoromethyl group at the 2-position of the [1,2,4]triazolo[1,5-<em>a>]pyrimidine ring led to increased drug activity. Thirteen compounds were found to be active, with IC50 values ranging from 0.023 to 20 µM in the anti-HRP2 and hypoxanthine assays. The selectivity index (SI of the most active derivatives 5, 8, 11 and 16 was found to vary from 1,003 to 18,478.

  8. EM International. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    1993-07-01

    It is the intent of EM International to describe the Office of Environmental Restoration and Waste Management`s (EM`s) various roles and responsibilities within the international community. Cooperative agreements and programs, descriptions of projects and technologies, and synopses of visits to international sites are all highlighted in this semiannual journal. Focus on EM programs in this issue is on international collaboration in vitrification projects. Technology highlights covers: in situ sealing for contaminated sites; and remote sensors for toxic pollutants. Section on profiles of countries includes: Arctic contamination by the former Soviet Union, and EM activities with Germany--cooperative arrangements.

  9. Credit scoring for individuals

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    Maria DIMITRIU

    2010-12-01

    Full Text Available Lending money to different borrowers is profitable, but risky. The profits come from the interest rate and the fees earned on the loans. Banks do not want to make loans to borrowers who cannot repay them. Even if the banks do not intend to make bad loans, over time, some of them can become bad. For instance, as a result of the recent financial crisis, the capability of many borrowers to repay their loans were affected, many of them being on default. That’s why is important for the bank to monitor the loans. The purpose of this paper is to focus on credit scoring main issues. As a consequence of this, we presented in this paper the scoring model of an important Romanian Bank. Based on this credit scoring model and taking into account the last lending requirements of the National Bank of Romania, we developed an assessment tool, in Excel, for retail loans which is presented in the case study.

  10. Publishing medical schools’ USMLE Step 1 scores: increase preclinical education accountability and national standards

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    Eltorai AE

    2013-08-01

    Full Text Available Adam EM Eltorai Brown University, Warren Alpert Medical School, Providence, RI, USA Medical education innovation is a field of active investigation.1,2 Whether it is problem-based learning, lectures, discussion groups, systems-based blocks, integrated courses, video-captured, pass-fail, or iPad-requiring, every medical school approaches preclinical education differently. Which combination of these methods is most effective?To answer this, I propose that medical schools ought to be required to publish their average United States Medical Licensing Examination (USMLE Step 1 scores annually. In doing so, the most effective education methods will emerge.

  11. Escalas de Ramsay e Richmond são equivalentes para a avaliação do nível de sedação em pacientes gravemente enfermos Ramsay and Richmond's scores are equivalent to assessment sedation level on critical patients

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    Ciro Leite Mendes

    2008-12-01

    Full Text Available OBJETIVO: O objetivo principal deste estudo foi comparar o desempenho das escalas de sedação de Ramsay e Richmond em pacientes críticos sob ventilação mecânica em um hospital universitário. MÉTODOS: Estudo prospectivo onde foram incluídos todos os pacientes sob ventilação mecânica com pelo menos 48 horas de internação, durante quatro meses, totalizando 45 pacientes. Foram avaliados diariamente a modalidade de sedação, dose dos sedativos e analgésicos e o nível de sedação através das escalas de Ramsay e Richmond. O teste T de Student, os índices de correlação de Pearson e Spearman, e a elaboração de curvas Receiver Operating Characteristic (ROC foram utilizados para a análise estatística. RESULTADOS: A mortalidade geral observada foi de 60%. Nesta série, o tempo de sedação e a dose de sedativos utilizada não se correlacionaram com a mortalidade. Sedação profunda (Ramsay > 4 ou Richmond 0,78. Níveis adequados de sedação (Ramsay 2 a 4 ou Richmond 0 a -3 correlacionaram-se sensivelmente à probabilidade de sobrevivência, com uma ASC > 0,80. Em 63 evoluções (8,64% foram observados níveis baixos de sedação, porém não se evidenciou nenhuma correlação entre a ocorrência de agitação e prognósticos desfavoráveis. Houve uma boa correlação entre as escalas Ramsay e Richmond (Pearson > 0,810 - pOBJECTIVE: The main purpose of this study was to compare performance of the Ramsay and Richmond sedation scores on mechanically ventilated critically ill patients, in a university-affiliated hospital. METHODS: This was a 4-month prospective study, which included a total of 45 patients mechanically ventilated, with at least 48 hours stay in the intensive care unit. Each patient was assessed daily for sedation mode, sedative and analgesic doses and sedation level using the Ramsay and Richmond scores. Statistical analysis was made using Student's t-test, Pearson's and Spearman's correlation, and constructing ROC

  12. Estimativa do potencial produtivo em trigo utilizando sensor óptico ativo para adubação nitrogenada em taxa variável Wheat yield potential estimation using active optical sensor for site-specific nitrogen fertilization

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    Christian Bredemeier

    2013-01-01

    Full Text Available A adubação nitrogenada em trigo é baseada no potencial produtivo da cultura, teor de matéria orgânica do solo e cultura antecessora. A definição do potencial produtivo é complexa, pois este varia com as condições meteorológicas de cada ano específico. O objetivo deste trabalho foi avaliar a relação entre o índice de vegetação por diferença normalizada (NDVI, medido por sensor óptico ativo e o rendimento de grãos em quatro cultivares de trigo, visando a desenvolver procedimentos para a adubação nitrogenada em cobertura em taxa variável. O experimento foi realizado em campo em 2009. Foram avaliados o NDVI em diferentes estádios de desenvolvimento e o rendimento de grãos. As leituras do NDVI ao longo do ciclo ativo foram eficientes em identificar variações de produtividade do trigo. Assim, o potencial de produtividade pode ser estimado através de medições desse índice durante a ontogenia da planta. Pode-se adotar um modelo único para descrever a relação entre NDVI e potencial produtivo para as cultivares testadas neste trabalho.Nitrogen fertilization in spring wheat is based on yield potential, soil organic matter content and previous crop. Yield potential definition is difficult, since it is affected by weather conditions. The objective of this research was to evaluate the relationship between Normalized Difference Vegetation Index (NDVI measured by an active sensor and grain yield of four wheat cultivars. The experiment was carried out at field conditions in 2009. NDVI in different growth stages and grain yield were evaluated. NDVI measured was efficient to detect growth variability generated by N availability and correlated well with grain yield for all cultivars tested, indicating that yield potential can be estimated by NDVI evaluations during crop ontogeny. One single model for the relationship between NDVI and yield potential can be used considering cultivars used in this research.

  13. Scoring clinical competencies of learners: A quantitative descriptive study

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    Ann Müller

    2011-02-01

    Full Text Available This article reports the correlation between different clinical assessors’ scoring of learners’ clinical competencies in order to exclude any possible extraneous variables with regard to reasons for poor clinical competencies of learners. A university in Gauteng, South Africa provides a learning programme that equips learners with clinical knowledge, skills and values in the assessment, diagnosis, treatment and care of patients presenting at primary health care (PHC facilities. The researcher observed that, despite additional clinical teaching and guidance, learners still obtained low scores in clinical assessments at completion of the programme. This study sought to determine possible reason(s for this observation. The objectives were to explore and describe the demographic profile of learners and the correlation between different clinical assessors’ scoring of learners. A purposive convenience sample consisted of learners (<em>n> = 34 and clinical assessors (<em>n> = 6. Data were collected from learners using a self-administered questionnaire and analysed using a nominal and ordinal scale measurement. Data from clinical assessors were collected using a checklist, which was statistically analysed using a software package. The variables were correlated to determine the nature of the relationship between the different clinical assessors’ scores on the checklist to ensure inter-rater reliability. Findings showed that there was no significant difference in the mean of the scoring of marks between clinical assessors after correlation (<em>p> < 0.05. Thus, scoring of marks did not contribute to poor clinical competencies exhibited by learners.

    Opsomming

    Hierdie artikel beskryf die ondersoek na die korrelasie tussen verskillende kliniese assesseerders se puntetoekenning tydens assessering van leerders se kliniese vaardighede ten einde enige moontlike vreemde veranderlikes met betrekking tot redes vir swak

  14. [Scoring--criteria for operability].

    Science.gov (United States)

    Oestern, H J

    1997-01-01

    For therapeutic recommendations three different kinds of scores are essential: 1. The severity scores for trauma; 2. Severity scores for mangled extremities; 3. Intensive care scores. The severity of polytrauma patients is measurable by the AIS, ISS, RTS, PTS and TRISS which is a combination of RTS, ISS, age, and mechanism of injury. For mangled extremities there are also different scores available: MESI (Mangled Extremity Syndrome Index) and MESS (Mangled Extremity Severity Score). The aim of these scores is to assist in the indication with regard to amputate or to save the extremity. These scoring indices can be used to evaluate the severity of a systemic inflammatory reaction syndrome with respect to multiple organ failure. All scores are dynamic values which are variable with improvement of therapy.

  15. Observation on Intestinal Inflammatory Activity Index Score Before and after Changyuning Treatment%观察肠愈宁治疗溃疡性结肠炎前后肠炎症活动指数评分

    Institute of Scientific and Technical Information of China (English)

    谢晶日; 许明月; 刘朝霞; 李明

    2012-01-01

    目的:观察肠愈宁对活动期溃疡性结肠炎患者疗前与疗后肠炎症活动指数评分的影响.方法:活动期溃疡性结肠炎患者90例,1随机分为中药组、西药组及中药+西药组3组,分别予以口服肠愈宁颗粒,关沙拉嗪及肠愈宁颗粒和美沙拉嗪同时服用,疗前肠炎症活动指数(DAI)评分,分别服用药物治疗8周后对患者再次进行肠炎症活动指数(DAI)评分.结果:经药物治疗后通过肠炎症活动指数(DAI)评分表明中药+西药组治疗效果明显好于中药组,中药组治疗效果明显好于西药组.结论:肠愈宁治疗溃疡性结肠炎疗效显著.%Objective:To observe intestinal inflammatory activity index score before and after treatment of active ulcerative colitis patients treated with Changyuning granules. Methods :90 cases of active ulcerative colitis patients were randomly divided into TCM group,the western medicine group and TCM plus western medicine group,in which Changyuning granules,mesalamine and Changyuning granules and mesalazine only were respectively used. The intestinal inflammatory activity index ( DAI) score was measured before treatment,eight weeks after treatment,the score was measured again. Results: After drug treatment, intestinal inflammatory activity index( DAI) score showed that the treatment effect of TCM plus Western medicine group was significantly better than that of the TCM group,and the effect of TCM group treatment was significantly better than that of the Western medicine group. Conclusion: Changyuning could treat wlcerative colitis effectively.

  16. A comparison of manual therapy and active rehabilitation in the treatment of non specific low back pain with particular reference to a patient's Linton & Hallden psychological screening score: a pilot study

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    Stephenson Richard

    2007-11-01

    Full Text Available Abstract Background Clinical guidelines for the management of back pain frequently recommend 'manual therapy' as a first line intervention, with psychosocial screening and 'active rehabilitation' for those not improving at 6 weeks post onset. The potential for psychosocial factors to predict treatment response and therefore outcome has not been adequately explored. The purpose of this pilot study was to determine the feasibility of a study to compare manual therapy and active rehabilitation outcomes for subjects with sub-acute/chronic back pain, investigate whether any difference in outcome was related to psychosocial factors, and to inform the design of a main study. Methods A convenience sample of 39 patients with non-specific low back pain referred to the physiotherapy department of an acute NHS Trust hospital was recruited over a nine month period. Patients completed the Linton and Hallden psychological screening questionnaire (LH and were allocated to a low LH (105 or below or high LH (106 or above scoring group. The low or high LH score was used to sequentially allocate patients to one of two treatment groups – Manual Therapy comprising physiotherapy based on manual means as chosen by the treating therapist or Active Rehabilitation comprising a progressive exercise and education programme – with the first low LH scoring patient being allocated to active rehabilitation and the next to manual therapy and so on. Treatment was administered for eight sessions over a four-week period and outcome measures were taken at baseline and at four weeks. Measures used were the Roland Morris Questionnaire (RMQ, two components of the Short Form McGill (total pain rating index [PRI] and pain intensity via visual analogue scale [VAS], and the LH. Results The manual therapy group demonstrated a greater treatment effect compared with active rehabilitation for RMQ (mean difference 3.6, 95% CI 1.1 – 6.2, p = 0.006 and PRI (7.1, 95% CI 2.0 – 12.2, p = 0

  17. A Comparison between Two Instruments for Assessing Dependency in Daily Activities: Agreement of the Northwick Park Dependency Score with the Functional Independence Measure

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    Siv Svensson

    2012-01-01

    Full Text Available Background. There is a need for tools to assess dependency among persons with severe impairments. Objectives. The aim was to compare the Functional Independence Measure (FIM and the Northwick Park Dependency Score (NPDS, in a sample from in-patient rehabilitation. Material and Methods. Data from 115 persons (20 to 65 years of age with neurological impairments was gathered. Analyses were made of sensitivity, specificity, positive predictive value, and negative predictive value. Agreement of the scales was assessed with kappa and concordance with Goodman-Kruskal’s gamma. Scale structures were explored using the Rank-Transformable Pattern of Agreement (RTPA. Content validation was performed. Results. The sensitivity of the NPDS as compared to FIM varied between 0.53 (feeding and 1.0 (mobility and specificity between 0.64 (mobility and 1.0 (bladder. The positive predictive value varied from 0.62 (mobility to 1.0 (bladder, and the negative predictive value varied from 0.48 (bowel to 1.0 (mobility. Agreement between the scales was moderate to good (four items and excellent (three items. Concordance was good, with a gamma of −.856, an asymptotic error (ase of .025, and P<.000. The parallel reliability between the FIM and the NPDS showed a tendency for NPDS to be more sensitive (having more categories when dependency is high. Conclusion. FIM and NPDS complement each other. NPDS can be used as a measure for severely injured patients who are sensitive when there is a high need of nursing time.

  18. Relationship of Apgar Scores and Bayley Mental and Motor Scores

    Science.gov (United States)

    Serunian, Sally A.; Broman, Sarah H.

    1975-01-01

    Examined the relationship of newborns' 1-minute Apgar scores to their 8-month Bayley mental and motor scores and to 8-month classifications of their development as normal, suspect, or abnormal. Also investigated relationships between Apgar scores and race, longevity, and birth weight. (JMB)

  19. Oxidative enzymes activities from Lentinula edodes on agribusiness substrate / Atividade de enzimas oxidativas do Lentinula edodes em substratos agroindustriais

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    Claudio Perani

    2009-12-01

    Full Text Available Basidyomycete Lentinula edodes has its related enzymatic activity mainly on the agribusiness waste kind used as a substrate. The objective of this work was to verify the activity of oxidative enzymes lacase (Lac, lignina peroxidase (LiP and manganese peroxidase (MnP of three L. edodes strains, in stationary system, cultivated the 25 ºC, in the absence of light, in substrates wtih 20% of bran of rice, 1% of CaCO3 and 79% of rice husk (CA, eucalyptus sawdust (SE, cassava bagasse (BM and sugarcane bagasse (BC, adjusted to 60% of humidity. The Lac and MnP activities were bigger in eucalyptus sawdust (SE and sugarcane bagasse (BC. The LiP activity was not induced for tested substrates. The rice husk (CA and cassava bagasse (BM substrates, although are not adequate to produce Lac or MnP, can be used as additives to increase the porosity, air availability and easy metabolism polysaccharides.O basidiomiceto Lentinula edodes tem sua atividade enzimática relacionada, principalmente, ao tipo de resíduo agroindustrial utilizado como substrato. O objetivo deste trabalho foi verificar a atividade das enzimas oxidativas lacase (Lac, lignina peroxidase (LiP e manganês peroxidase (MnP de três linhagens de L. edodes, em sistema estacionário, cultivadas a 25 ºC, na ausência de luz, em substratos compostos de 20% de farelo de arroz, 1% de CaCO3 e 79% de casca de arroz (CA, serragem de eucalipto (SE, bagaço de mandioca (BM e bagaço de cana-de-açúcar (BC, ajustados à 60% de umidade. As atividades de Lac e MnP foram maiores nos substratos a base de serragem de eucalipto (SE e bagaço de cana-de-açúcar (BC. A atividade de LiP não foi induzida pelos substratos testados. Os substratos à base de casca de arroz (CA e bagaço de mandioca (BM, não se mostraram adequados na indução da produção de Lac ou MnP, mas podem ser utilizados como aditivos para aumentar a porosidade, disponibilidade de ar e fornecer polissacarídeos de fácil metabolização.

  20. There Is No Further Gain from Calculating Disease Activity Score in 28 Joints with High Sensitivity Assays of C-Reactive Protein Because of High Intraindividual Variability of CRP

    DEFF Research Database (Denmark)

    Jensen Hansen, Inger Marie; Asmussen Andreasen, Rikke; Antonsen, Steen

    2016-01-01

    Background/Purpose: The threshold for reporting of C-reactive protein (CRP) differs from laboratory to laboratory. Moreover, CRP values are affected by the intra individual biological variability.[1] With respect to disease activity score in 28 joints (DAS28) and Rheumatoid Arthritis (RA), precise...... reporting limit for CRP to minimumFigure 1). The logarithmic transformation of CRP in DAS28 formula has an important role Cross sectional study: 769 patients fulfilled the ACR criteria for RA were included, 107 excluded due to missing parameter used...

  1. There Is No Further Gain from Calculating Disease Activity Score in 28 Joints with High Sensitivity Assays of C-Reactive Protein Because of High Intraindividual Variability of CRP: A Cross Sectional Study and Theoretical Consideration

    DEFF Research Database (Denmark)

    Jensen Hansen, Inger Marie; Asmussen Andreasen, Rikke; Antonsen, Steen

    Background/Purpose: The threshold for reporting of C-reactive protein (CRP) differs from laboratory to laboratory. Moreover, CRP values are affected by the intra individual biological variability.[1] With respect to disease activity score in 28 joints (DAS28) and Rheumatoid Arthritis (RA), precise...... reporting limit for CRP to minimumFigure 1). The logarithmic transformation of CRP in DAS28 formula has an important role Cross sectional study: 769 patients fulfilled the ACR criteria for RA were included, 107 excluded due to missing parameter used...

  2. Atividade microbiana do solo em sistemas agroflorestais, monoculturas, mata natural e área desmatada Soil microbial activity in agroforest, monocultures, natural forest and deforested area systems

    Directory of Open Access Journals (Sweden)

    Sebastião Lourenço de Assis Júnior

    2003-02-01

    Full Text Available Este trabalho foi desenvolvido na Unidade Agroflorestal da Companhia Mineira de Metais (CMM, em Vazante, Estado de Minas Gerais, com o objetivo de estudar a atividade microbiana em diferentes ecossistemas, como sistemas agroflorestais (SAFs, monoculturas, área desmatada e mata natural, utilizando os métodos da respirometria no laboratório e da medida não-instantânea da taxa de evolução de CO2 no campo. A atividade biológica apresentou valores acumulados das taxas de respiração do solo, aos 20 dias, de 3,56 a 6,03 meq C-CO2/100 g de solo no laboratório e de 165,16 a 559,37 mg CO2/m-2.h no campo, na área desmatada e na mata nativa, respectivamente. Em ambos os ensaios, a atividade foi maior na mata nativa e nas pastagens, tanto em monocultivo quanto em SAFs. A atividade microbiana foi maior em SAF com arroz e eucalipto do que em arroz em monocultivo, pelo método no campo.This research was developed in the Agroforestry Unit of the "Companhia Mineira de Metais (CMM", Vazante, Minas Gerais, Brazil, to study microbial activity in different ecosystems such as agroforests, monocultures, deforested areas and native forests using the method of respirometry under laboratory conditions and CO2 evaluation rate evolution under field conditions. Biological activity showed accumulated values of respiration rates at 20 days of 3.56 to 6.03 meq C-CO2/100 g of soil in the laboratory, and 165.16 to 559.37 mg CO2/m-2.h in the field, in deforested area and native forest, respectively. Activity was higher in native forest and pasture than in monoculture or agroforestry, in both experiments. Microbial activity was higher in agroforestry with rice and eucalypt than with rice in monoculture, under field conditions.

  3. Arctic Animals of Alaska. First Grade Activity. Schools of California Online Resources for Education (SCORE): Connecting California's Classrooms to the World.

    Science.gov (United States)

    Boe, Sandra

    The Arctic is covered with ice and snow for most of the year. Animals that live in Alaska's arctic region must be able to survive long winters and very cold temperatures. Surprisingly, many animals live in the harsh, cold climate. This first-grade activity plan helps students learn about the animals of the far north. The plan gives six steps for…

  4. Using Momentary Time Sampling to Estimate Minutes of Physical Activity in Physical Education: Validation of Scores for the System for Observing Fitness Instruction Time

    Science.gov (United States)

    Heath, Edward M.; Coleman, Karen J.; Lensegrav, Tera L.; Fallon, Jennifer A.

    2006-01-01

    The System for Observing Fitness Instruction Time (SOFIT) is a direct observation system specifically developed for use during physical education (PE; McKenzie, 1991; McKenzie, Sallis, & Nader, 1991). The purpose of this study was to validate the estimates of time spent in various physical activity intensities obtained with the paper and pencil…

  5. Orange Juice--From the Tree to the Glass! Second Grade Activity. Schools of California Online Resources for Education (SCORE): Connecting California's Classrooms to the World.

    Science.gov (United States)

    Ricchiuti, Linda M.

    The goal of this lesson plan is for second-grade students to understand the steps in how food is made and delivered to the grocery store. Students create a play where each person plays a part in the production and distribution of food. The lesson suggests that the class perform the play on parents' night. It provides five activities for students…

  6. Suppression of EM Fields using Active Control Algorithms and MIMO Antenna System

    Directory of Open Access Journals (Sweden)

    A. Mohammed

    2004-09-01

    Full Text Available Active methods for attenuating acoustic pressure fields have beensuccessfully used in many applications. In this paper we investigatesome of these active control methods in combination with a MIMO antennasystem in order to assess their validity and performance when appliedto electromagnetic fields. The application that we evaluated in thispaper is a model of a mobile phone equipped with one ordinarytransmitting antenna and two actuator-antennas which purpose is toreduce the electromagnetic field at a specific area in space (e.g. atthe human head. Simulation results show the promise of using theadaptive active control algorithms and MIMO system to attenuate theelectromagnetic field power density.

  7. Line Lengths and Starch Scores.

    Science.gov (United States)

    Moriarty, Sandra E.

    1986-01-01

    Investigates readability of different line lengths in advertising body copy, hypothesizing a normal curve with lower scores for shorter and longer lines, and scores above the mean for lines in the middle of the distribution. Finds support for lower scores for short lines and some evidence of two optimum line lengths rather than one. (SKC)

  8. Developmental Sentence Scoring for Japanese

    Science.gov (United States)

    Miyata, Susanne; MacWhinney, Brian; Otomo, Kiyoshi; Sirai, Hidetosi; Oshima-Takane, Yuriko; Hirakawa, Makiko; Shirai, Yasuhiro; Sugiura, Masatoshi; Itoh, Keiko

    2013-01-01

    This article reports on the development and use of the Developmental Sentence Scoring for Japanese (DSSJ), a new morpho-syntactical measure for Japanese constructed after the model of Lee's English Developmental Sentence Scoring model. Using this measure, the authors calculated DSSJ scores for 84 children divided into six age groups between 2;8…

  9. Radionuclides incorporation in activated natural nanotubes; Incorporacao de radionuclideos em nanotubos naturais ativados

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Jose Parra

    2016-11-01

    Natural palygorskite nanotubes show suitable physical and chemical properties and characteristics to be use as potential nanosorbent and immobilization matrix for the concentration and solidification of radionuclides present in nuclear wastes. In the development process of materials with sorption properties for the incorporation and subsequent immobilization of radionuclides, the most important steps are related with the generation of active sites simultaneously to the increase of the specific surface area and suitable heat treatment to producing the structural folding. This study evaluated the determining parameters and conditions for the activation process of the natural palygorskite nanotubes aiming at the sorption of radionuclides in the nanotubes structure and subsequent evaluation of the parameters involve in the structural folding by heat treatments. The optimized results about the maximum sorption capacity of nickel in activated natural nanotubes show that these structures are apt and suitable for incorporation of radionuclides similar to nickel. By this study is verified that the optimization of the acid activation process is fundamental to improve the sorption capacities for specifics radionuclides by activated natural nanotubes. Acid activation condition optimized maintaining structural integrity was able to remove around 33.3 wt.% of magnesium cations, equivalent to 6.30·10{sup -4} g·mol{sup -1}, increasing in 42.8% the specific surface area and incorporating the same molar concentration of nickel present in the liquid radioactive waste at 80 min. (author)

  10. The association between physical activity, sedentary behavior, sleep, and body mass index z-scores in different settings among toddlers and preschoolers

    OpenAIRE

    Kuzik, Nicholas; Carson, Valerie

    2016-01-01

    Background Physical activity, sedentary behavior, and sleep are all movement behaviors that range on a continuum from no or low movement, to high movement. Consistent associations between movement behaviors and adiposity indicators have been observed in school-age children. However, limited information exists in younger children. Since approximately 50 % of Canadian children ≤5 years of age attend non-parental care, movement behaviors within and outside of the child care setting are important...

  11. Credit Scoring Modeling

    Directory of Open Access Journals (Sweden)

    Siana Halim

    2014-01-01

    Full Text Available It is generally easier to predict defaults accurately if a large data set (including defaults is available for estimating the prediction model. This puts not only small banks, which tend to have smaller data sets, at disadvantage. It can also pose a problem for large banks that began to collect their own historical data only recently, or banks that recently introduced a new rating system. We used a Bayesian methodology that enables banks with small data sets to improve their default probability. Another advantage of the Bayesian method is that it provides a natural way for dealing with structural differences between a bank’s internal data and additional, external data. In practice, the true scoring function may differ across the data sets, the small internal data set may contain information that is missing in the larger external data set, or the variables in the two data sets are not exactly the same but related. Bayesian method can handle such kind of problem.

  12. Aplicação do escore MELD em pacientes submetidos a transplante de fígado: análise retrospectiva da sobrevida e dos fatores preditivos a curto e longo prazo The application of MELD score in patients submitted to liver transplantation: a retrospective analysis of survival and the predictive factors in the short and long term

    Directory of Open Access Journals (Sweden)

    Ilka de Fátima Santana Ferreira Boin

    2008-12-01

    (65,16% vs 44,44%. A sobrevida aos 5 e 10 anos também seguiu o mesmo padrão. O uso de doadores limítrofes não alterou a sobrevida, mas quando se utilizou o índice de risco do doador observou-se que a sobrevida foi maior para pacientes com índice de risco do doador menor que 1,7 (63,62% vs 53,70%. A associação deste índice com o escore MELD não mostrou diferença estatística em relação à sobrevida. Observou-se que a falência e disfunção do enxerto foram associadas ao número crescente de critérios expandidos do doador. Os receptores de doadores maiores de 50 anos tiveram menor sobrevida (65,58% vs 38,40% e o escore delta-MELD não discriminou a sobrevida. CONCLUSÃO: A sobrevida dos receptores a curto e longo prazo é associada a escores MELD acima de 25, ao volume de sangue transfundido, à disfunção do enxerto, à hiponatremia, à idade do doador acima de 50 anos e àqueles doadores com índice de risco do doador acima de 1,7.BACKGROUND: The model for end-stage liver disease (MELD was developed to predict short-term mortality in patients with cirrhosis. There are few reports studying the correlation between MELD and long-term posttransplantation survival. AIM: To assess the value of pretransplant MELD in the prediction of posttransplant survival. METHODS: The adult patients (age >18 years who underwent liver transplantation were examined in a retrospective longitudinal cohort of patients, through the prospective data base. We excluded acute liver failure, retransplantation and reduced or split-livers. The liver donors were evaluated according to: age, sex, weight, creatinine, bilirubin, sodium, aspartate aminotransferase, personal antecedents, brain death cause, steatosis, expanded criteria donor number and index donor risk. The recipients' data were: sex, age, weight, chronic hepatic disease, Child-Turcotte-Pugh points, pretransplant and initial MELD score, pretransplant creatinine clearance, sodium, cold and warm ischemia times, hospital length

  13. Track score processing of multiple dissimilar sensors

    OpenAIRE

    Patsikas, Dimitrios

    2007-01-01

    In this thesis, a data fusion problem when a number of different types of sensors are deployed in the vicinity of a ballistic missile launch is studied. An objective of this thesis is to calculate a scoring function for each sensor track, and the track file with the best (optimum) track score can then be used for guiding an interceptor to the threat within the boost phase. Seven active ground-based radars, two space-based passive infrared sensors and two active light detection and rangin...

  14. O uso do custeio baseado em atividades: ABC (Activity Based Costing nas maiores empresas de Santa Catarina

    Directory of Open Access Journals (Sweden)

    Ilse Maria Beuren

    2002-12-01

    Full Text Available Devido à globalização da economia, as empresas evoluíram para a produção de enormes variedades de produtos personalizados. Com o intuito de atender às exigências dos clientes, surgiu a necessidade de grandes alterações nos processos tecnológicos. Como conseqüência, os custos indiretos passaram a ser mais significativos, o que implicou um novo método de distribuição desses custos, capaz de distribuir melhor os custos indiretos aos produtos e serviços. A esse método foi dado o nome de custeio baseado em atividades - ABC (Activity Based Costing. Esse método foi investigado por Carlos Yorghi Khoury em 1996, numa pesquisa aplicada às 500 maiores empresas do Brasil. O objetivo deste trabalho foi replicar essa pesquisa nas maiores empresas catarinenses, a fim de observar se esses resultados obtidos assemelham-se aos obtidos na pesquisa com as empresas catarinenses.Nesta pesquisa, dos 200 questionários enviados para as maiores empresas de Santa Catarina, 81 retornaram com as questões respondidas. O trabalho levou a conclusões importantes, como: as empresas de Santa Catarina têm amplo conhecimento do sistema ABC; algumas empresas que implantaram esse sistema já estão desistindo de seu uso, em função da complexidade para apropriar os custos indiretos e as despesas às atividades e estas aos produtos.Due to the economic globalization, enterprises have started to produce enormous varieties of personalized products. In order to attend to the requirements of their clients, huge changes in the technological process were needed. Consequently, indirect costs became more significant, which led to a new method for distributing the indirect costs, capable of better distributing the indirect costs of products and services.This method was called Activity Based Costing and was investigated by Carlos Yorghi Khoury in 1996 through a research applied in the 500 biggest companies in Brazil. This paper aims to replicate the 1996 research in the

  15. Parâmetros genéticos para escore de umbigo e características de produção em bovinos da raça Nelore Genetics parameters for umbilicus score and production characteristics in Nellore breed beef cattle

    Directory of Open Access Journals (Sweden)

    W. Koury Filho

    2003-10-01

    Full Text Available Utilizaram-se 11.310 medidas de escore visual da característica umbigo, medida aos 18 meses em bovinos, para estimar os componentes de variância, a herdabilidade e as correlações genéticas entre escore do umbigo e peso à desmama (PD e ganho de peso da desmama ao sobreano (GP345, utilizando-se modelo animal bi-característica Os escores de umbigo (EU variaram de 1 (mais pendulosos a 5 (mais curtos. Os valores de herdabilidade foram 0,31 (PD, 0,14 (GP345 e 0,29 (EU, e as correlações genéticas foram -0,05 (EU×PD e 0,14 (EU×GP345. A correlação entre avaliação do umbigo de machos e fêmeas foi de 0,80. Conclui-se que a característica umbigo é passível de seleção e que ela não compromete a seleção para melhores PD e GP345.In this study 11,310 visual score measurements of navel characteristic, collected from bovines, were used. Visual scores for navel (NS, ranged from 1 (the longest to 5 (the shortest. Variance components, genetic parameters and genetic correlations between navel characteristic of 18-month old animals and growth characteristics (weaning weight -WW and weight gain from weaning to over year -WG345 were estimated using a two-traits animal model. Heritability estimates were 0.31 (NS abd 0.14 (WG345, and the genetic correlation estimates were: -0.05 (NS×WW and 0.14 (WW×WG345 and the estimated correlation between navel (female ´ navel (male was 0.80. Score navel can be object of selection and selection for shorter navel does not apparently significantly affect animal performance for WW and WG345.

  16. Avaliação de dietas para eqüinos de uso militar em atividade física moderada Evaluation of diets for military horses in moderate activity

    Directory of Open Access Journals (Sweden)

    Patrícia Maia Galvão

    2004-12-01

    Full Text Available Objetivou-se, com o presente trabalho, avaliar dietas de cavalos de uso militar em atividade física moderada. O experimento foi realizado no Regimento Escola de Cavalaria do Exército Brasileiro, onde foram avaliadas as dietas dos eqüinos do Esquadrão de Cerimonial. No ensaio de desempenho, foi utilizado delineamento experimental em blocos casualizados, compostos de três tratamentos, sendo o bloco a idade dos animais e os tratamentos, as dietas experimentais. Na dieta I, quinze animais receberam dietas com ração comercial com feno de alfafa e coastcross incorporados ao pelete; na dieta II, quinze animais receberam ração comercial peletizada e, na dieta III, quatorze animais receberam ração comercial peletizada semelhante à dieta II, acrescida de 3,0 kg de aveia hidropônica. Em todas as dietas, foram adicionados 3,0 kg de feno de coastcross. Em seguida, foi conduzido o ensaio de digestão em delineamento inteiramente casualizado, com os três tratamentos supracitados e quatro repetições, além da coleta total de fezes, para avaliação da digestibilidade dos nutrientes das dietas experimentais. Os valores obtidos foram submetidos à análise de variância e as médias, comparadas pelo teste de Tukey, a 5% de probabilidade. Os animais alimentados com as dietas experimentais tiveram o peso vivo e escore corporal inalterados pelas variações dos conteúdos de nutrientes das mesmas. Os coeficientes de digestibilidade foram afetados pela dietas experimentais e, de acordo com os resultados observados, a dieta contendo ração comercial com feno incorporado ao pelete, mostrou-se mais digestível. O consumo de energia e proteína digestível nas dietas avaliadas foi adequado às atividades militares e o consumo de fibra dietética (expressa em FDN e FDA foi adequado às recomendações mínimas necessárias para os eqüinos.This study aims to evaluate diets for military horses in moderate activity. This experiment was conducted at Cavalry

  17. A high-resolution computed tomography-based scoring system to differentiate the most infectious active pulmonary tuberculosis from community-acquired pneumonia in elderly and non-elderly patients

    Energy Technology Data Exchange (ETDEWEB)

    Yeh, Jun-Jun [Ditmanson Medical Foundation Chia-Yi Christian Hospital, Section of Thoracic Imaging, Department of Chest Medicine and Family Medicine, Chiayi City (China); Chia Nan University of Pharmacy and Science, Tainan (China); Meiho University, Pingtung (China); Pingtung Christian Hospital, Pingtung (China); Chen, Solomon Chih-Cheng; Chen, Cheng-Ren [Ditmanson Medical Foundation Chia-Yi Christian Hospital, Department of Medical Research, Chiayi City (China); Yeh, Ting-Chun; Lin, Hsin-Kai; Hong, Jia-Bin; Wu, Bing-Tsang [Ditmanson Medical Foundation Chia-Yi Christian Hospital, Department of Family Medicine, Chiayi City (China); Wu, Ming-Ting [Department of Radiology, Kaohsiung Veterans General Hospital, Section of Thoracic and Circulation Imaging, Kaohsiung (China); School of Medicine, National Yang Ming University, Faculty of Medicine, Taipei (China)

    2014-10-15

    The objective of this study was to use high-resolution computed tomography (HRCT) imaging to predict the presence of smear-positive active pulmonary tuberculosis (PTB) in elderly (at least 65 years of age) and non-elderly patients (18-65 years of age). Patients with active pulmonary infections seen from November 2010 through December 2011 received HRCT chest imaging, sputum smears for acid-fast bacilli and sputum cultures for Mycobacterium tuberculosis. Smear-positive PTB was defined as at least one positive sputum smear and a positive culture for M. tuberculosis. Multivariate logistic regression analyses were performed to determine the HRCT predictors of smear-positive active PTB, and a prediction score was developed on the basis of receiver operating characteristic curve analysis. Of 1,255 patients included, 139 were diagnosed with smear-positive active PTB. According to ROC curve analysis, the sensitivity, specificity, positive predictive value, negative predictive value, false positive rates and false negative rates were 98.6 %, 95.8 %, 78.5 %, 99.8 %, 4.2 % and 1.4 %, respectively, for diagnosing smear-positive active PTB in elderly patients, and 100.0 %, 96.9 %, 76.5 %, 100.0 %, 3.1 % and 0.0 %, respectively, for non-elderly patients. HRCT can assist in the early diagnosis of the most infectious active PTB, thereby preventing transmission and minimizing unnecessary immediate respiratory isolation. (orig.)

  18. Predictive values at risk of falling in physically active and no active elderly with Berg Balance Scale Valores preditivos para o risco de queda em idosos praticantes e não praticantes de atividade física por meio do uso da Escala de Equilíbrio de Berg

    Directory of Open Access Journals (Sweden)

    Gilmar M. Santos

    2011-04-01

    Full Text Available BACKGROUND: The consequences of falls are a major cause of autonomy and independence loss among the elderly. In this context, the Berg Balance Scale (BBS has been widely used to detect the risk of falls in elderly. OBJECTIVE: To evaluate the predictive value of the BBS for fall risk in physically active and inactive elderly subjects. METHODS: The sample included 188 older adults with a mean age of 66 (±9 years. Of these, 91 participated in a regular physical activity program and 96 did not. We analyzed the cut-off scores of 45, 47, 49, 51 and 53 in both groups regarding the sensitivity (S, specificity (Sp, positive predictive value (PPV and negative predictive value (NPV of the test, including the positive likelihood ratio (PLR and negative likelihood ratio (RVN for diagnosing the risk of falls. RESULTS: The mean BBS score was 54.7 in physically active subjects and 50.8 in inactive subjects, which was statistically significant (ρ=0.001. The best cut-off was a score of 49 for physically inactive subjects, with a sensitivity of 91% and a specificity of 92%. On the other hand, the BBS had low sensitivity (from 0 to 15% and high specificity (between 83% and 100% for physically active subjects at the cut-off points analyzed. CONCLUSION: The scale did not achieve sufficient sensitivity to individual differences among physically active older people with higher levels of functional balance ability.CONTEXTUALIZAÇÃO: Umas das principais causas da perda da autonomia e independência do idoso são as consequências geradas pelas quedas. Nesse contexto, a Escala de Equilíbrio de Berg (EEB vem sendo amplamente utilizada para detectar o risco de queda em idosos. Objetivo: Analisar os valores preditivos para o risco de queda em idosos praticantes e não-praticantes de atividade física por meio do uso da EEB. MÉTODOS: Participaram 188 idosos, com média de idade de 66 (±9 anos. Desses, 91 participavam de projetos de atividades físicas, e 96 n

  19. Validação de um escore para predição de eventos hemorrágicos em síndromes coronarianas agudas Validación de un escore para predicción de eventos hemorrágicos en síndromes coronarios agudos Validation of a score for predicting bleeding events during acute coronary syndromes

    Directory of Open Access Journals (Sweden)

    Luis C. L. Correia

    2010-10-01

    Full Text Available FUNDAMENTO: Sangramento é uma complicação grave em pacientes tratados para síndromes coronarianas agudas (SCA com antitrombóticos e terapias invasivas. Consequentemente, o benefício dessas terapias deve ser analisado contra os potenciais riscos de complicações hemorrágicas. Desta forma, a determinação de um escore para estimar o risco individual de sangramento pode representar uma importante ferramenta na tomada de decisões clínicas. OBJETIVO: Criar e validar um escore de risco de sangramento para pacientes com SCA. MÉTODOS: Foram utilizados preditores independentes de sangramento relatados pelo Registro GRACE. Variáveis com odds ratio (OR > 2,5 nesse Registro somaram 3 pontos (histórico anterior de sangramento, OR=1,5-2,4 somaram 2 pontos (clearance de creatinina 30, infra ou supra-desnivelamento do segmento ST, doença arterial periférica e fumo. O escore foi validado em uma coorte de 383 indivíduos com SCA. Sangramento hospitalar foi definido como queda de hematócrito > 10%, transfusão de sangue > 2 unidades, sangramento intracerebral ou sangramento fatal. RESULTADOS: A incidência de eventos hemorrágicos foi de 3,1% e a estatística-C do escore foi 0,66 (IC95% = 0,52-0,80, indicando capacidade preditiva para esses eventos. Aqueles com escore > 7 apresentaram 6% de incidência de sangramento, comparados com 1,9% se o escore era 7 e um maior risco imposto pelo tratamento com Clopidogrel (p=0,02, bloqueadores IIb/IIIa (p=0,06 e revascularização cirúrgica (p FUNDAMENTO: Sangrado es una complicación grave en pacientes tratados por síndromes coronarios agudos (SCA con antitrombóticos y terapias invasivas. Consecuentemente, el beneficio de esas terapias debe ser analizado contra los potenciales riesgos de complicaciones hemorrágicas. De esta forma, la determinación de un escore para estimar el riesgo individual de sangrado puede representar una importante herramienta en la toma de decisiones clínicas. OBJETIVO: Crear y

  20. Atividade física e desempenho em tarefas de funções executivas em idosos saudáveis: dados preliminares Physical activity and performance in executive function tasks in healthy older adults: preliminary data

    Directory of Open Access Journals (Sweden)

    Andreza Giuliane Guimarães Moreira

    2010-01-01

    Full Text Available CONTEXTO: A atividade física parece exercer um efeito positivo sobre vários processos cognitivos em idosos. Entretanto, pouco se sabe sobre o impacto da atividade física sequencial, como a dança, sobre as funções executivas dos idosos. OBJETIVO: Avaliar a relação entre o tipo de atividade física praticada e o desempenho em tarefas de funções executivas em idosos. MÉTODOS: Participaram do estudo 35 idosos entre 60 e 69 anos de idade. O grupo controle (GC foi composto por idosos sedentários; o grupo ativos (GA foi composto por idosos praticantes de atividade física; o grupo dança (GD foi composto por idosos praticantes de atividade física idêntica ao GA acrescido da prática de dança sênior. Após uma triagem inicial, todos os participantes foram submetidos a testes de funções executivas. RESULTADOS: Comparado aos demais grupos, o GD apresentou melhor desempenho em termos de (1 planejamento, medida essa observada no teste da Torre de Londres e (2 controle inibitório, por meio do teste de Stroop. CONCLUSÕES: Os resultados preliminares encontrados sugerem uma especificidade da atividade física sobre o desempenho de determinadas funções executivas. A perspectiva é de que com uma maior amostra esses achados sejam mantidos.BACKGROUND: Physical activity seems to produce positive effects on many cognitive processes in elderly people. Nevertheless, little is known about the impact of sequential physical activity, such as dancing, on the executive functions in older adults. OBJECTIVE: To evaluate, in elderly people, the relation between the type of physical practice and the performance in executive functions. METHODS: Thirty five older adults, age 60-69, participated in this study. The control group (CD was composed by sedentary participants; the physical activity group (PAG was composed by practitioners of physical activity; the dance group (DG was composed by practitioner of identical physical activity to the PAG plus practice

  1. <em>In Vitro em>and <em>in em>Vivo> Antitumor Effect of Trachylobane-360, a Diterpene from<em> Xylopia langsdorffianaem>

    Directory of Open Access Journals (Sweden)

    João Carlos Lima Rodrigues Pita

    2012-08-01

    Full Text Available Trachylobane-360 (<em>ent>-7α-acetoxytrachyloban-18-oic acid was isolated from <em>Xylopia langsdorffianaem>. Studies have shown that it has weak cytotoxic activity against tumor and non-tumor cells. This study investigated the <em>in vitroem>> em>and <em>in vivoem> antitumor effects of trachylobane-360, as well as its cytotoxicity in mouse erythrocytes. In order to evaluate the <em>in vivoem> toxicological aspects related to trachylobane-360 administration, hematological, biochemical and histopathological analyses of the treated animals were performed. The compound exhibited a concentration-dependent effect in inducing hemolysis with HC50 of 273.6 µM, and a moderate <em>in vitroem>> em>concentration-dependent inhibitory effect on the proliferation of sarcoma 180 cells with IC50 values of 150.8 µM and 150.4 µM, evaluated by the trypan blue exclusion test and MTT reduction assay, respectively. The <em>in vivoem> inhibition rates of sarcoma 180 tumor development were 45.60, 71.99 and 80.06% at doses of 12.5 and 25 mg/kg of trachylobane-360 and 25 mg/kg of 5-FU, respectively. Biochemical parameters were not altered. Leukopenia was observed after 5-FU treatment, but this effect was not seen with trachylobane-360 treatment. The histopathological analysis of liver and kidney showed that both organs were mildly affected by trachylobane-360 treatment. Trachylobane-360 showed no immunosuppressive effect. In conclusion, these data reinforce the anticancer potential of this natural diterpene.

  2. Flavonoides e atividade antioxidante em Palicourea rigida Kunth, Rubiaceae Flavonoids and antioxidant activity in Palicourea rigida Kunth, Rubiaceae

    Directory of Open Access Journals (Sweden)

    Elisa A. da Rosa

    2010-09-01

    Full Text Available A atividade antioxidante, avaliada pelo método DPPH (1,1-difenil-2-picrilidrazila, e o teor em compostos fenólicos totais do extrato bruto metanólico e frações das folhas da espécie Palicourea rigida Kunth, Rubiaceae, foram quantificadas neste trabalho. Apesar da baixa atividade apresentada pelo extrato bruto (500 ppm, a fração acetato de etila apresentou atividade moderada (192 ppm e o maior teor de fenólicos totais dentre as frações ensaiadas. Assim, a fração acetato de etila foi submetida a procedimentos cromatográficos o que resultou no isolamento dos flavonoides quercetina 3-O-β-D-glicosídeo, quercetina 3-O-soforosídeo e isoraminetina 3-glicosídeo, cujas estruturas foram elucidadas por análise espectroscópica, incluindo RMN (1D e 2D e comparação com os dados da literatura.The antioxidant activity, evaluated by DPPH (1,1-difenil-2-picrilidrazila method, and the determination of the total phenolic compounds of the crude methanolic extract and fractions of the Palicourea rigida Kunth, Rubiaceae, leaves were quantified in this work. Despite weak activity exhibited by crude extract (500 ppm, the fraction ethyl acetate showed moderate activity (192 ppm, and the largest value for the phenolic compounds among all the assayed fractions. Then, the ethyl acetate fraction was submitted to the chromatography procedures which led to the isolation of the flavonoid quercetin 3-O-D-glicoside, quercetin 3-O-sophoroside and isorhamnetin 3-glicoside, which had the structures elucidated by spectroscopy analysis, including RMN (1D and 2D and comparison with literature data.

  3. <em>In Vitroem> Antioxidant Properties of Flavonoids and Polysaccharides Extract from Tobacco (<em>Nicotiana> em>tabacum> L. Leaves

    Directory of Open Access Journals (Sweden)

    Jing-Lu Wang

    2012-09-01

    Full Text Available In the present study, antioxidant properties of flavonoids and polysaccharides from tobacco (<em>Nicotiana> tabacumem> L. leaves were evaluated in several <em>in vitroem> systems, e.g., scavenging activities on hydroxyl, superoxide anion, 1,1-diphenyl-2-picrylhydrazyl (DPPH and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid (ABTS radicals, and reducing power. Flavonoids showed much better activity than polysaccharides in scavenging activities on free radicals. When compared to the positive control, ascorbic acid, both showed weaker antioxidant potential. However, flavonoids possessed comparable superoxide anion, DPPH and ABTS radical scavenging abilities to ascorbic acid at high concentration (600 μg/mL. Meanwhile, it was found that flavonoids had prominent effects on the reducing power, which was equivalent to ascorbic acid, and was significantly higher than polysaccharides. These results clearly indicate that flavonoids are effective in scavenging free radicals and have the potential to be powerful antioxidants. Thus, tobacco leaves could be considered as a potential source of natural antioxidants for food, pharmaceutical, cosmetics or nutraceutical industries.

  4. Objective assessment of topical anti-inflammatory drug activity on experimentally induced nickel contact dermatitis: comparison between visual scoring, colorimetry, laser Doppler velocimetry and transepidermal water loss.

    Science.gov (United States)

    Queille-Roussel, C; Duteil, L; Padilla, J M; Poncet, M; Czernielewski, J

    1990-01-01

    Four topical anti-inflammatory drugs were investigated for their effect on allergic contact dermatitis. Nickel dermatitis was chosen for its high incidence in European healthy volunteers. Experimental lesions were treated twice daily with two steroids, two non-steroidal anti-inflammatory drugs and a blank base for 4.5 days without occlusion. The influence of treatments was assessed by daily visual grading and one site was left untreated for comparison over the same period. To quantify drug activities objectively, skin colour (colorimetry), skin blood flow (laser Doppler velocimetry) and transepidermal water loss (evaporimetry) were measured before drugs were first applied, then 6 hr after the last application. As expected, only Dermoval cream significantly improved the spontaneous clinical evolution in comparison with the other creams (Hydrocortisone Aster à 1%. Parfenac, indomethacin 2.5% and Skinbase) and the untreated site. Colorimetric parameter a* (redness) and L* (luminance) showed more differences between treatments than the other criteria and a close relationship was obtained between these two parameters and skin blood flow, all three being highly correlated to visual grading. Transepidermal water loss appeared less related to clinical improvement but this parameter could prove helpful for detecting compounds which could be irritant to diseased skin.

  5. Short and Long-Term Effects of <em>Baccharis articulataem> on Glucose Homeostasis

    Directory of Open Access Journals (Sweden)

    Flávio H. Reginatto

    2012-06-01

    Full Text Available In this study, the<em> in vivoem> effect of the crude extract and <em>n>-butanol and aqueous residual fractions of <em>Baccharis articulataem> (Lam. Pers. on serum glucose levels, insulin secretion and liver and muscle glycogen content, as well as<em> in vitroem> action on serum intestinal disaccharidase activity and albumin glycation were investigated. Oral administration of the extract and fractions reduced glycemia in hyperglycemic rats. Additionally, the <em>n>-butanol fraction, which has high flavonoids content, stimulated insulin secretion, exhibiting an insulinogenic index similar to that of glipizide. Also, the <em>n>-butanol fraction treatment significantly increased glycogen content in both liver and muscle tissue. <em>In vitroem> incubation with the crude extract and <em>n>-butanol and aqueous residual fractions inhibited maltase activity and the formation of advanced glycation end-products (AGEs. Thus, the results demonstrated that <em>B. articulataem> exhibits a significant antihyperglycemic and insulin-secretagogue role. These effects on the regulation of glucose homeostasis observed for <em>B. articulataem> indicate potential anti-diabetic properties.

  6. Estudo comparativo entre o teste do pH e do KOH versus escore de Nugent para diagnóstico da vaginose bacteriana em gestantes Comparative study between the pH test and of the KOH versus Nugent score for diagnosis of bacterial vaginosis in pregnant women

    Directory of Open Access Journals (Sweden)

    Ana Aurélia Salles Campos

    2012-05-01

    Full Text Available OBJETIVO: Aquilatar a prevalência da vaginose bacteriana e comparar a acurácia dos testes do pH e do KOH com o gradiente de Nugent, método padrão-ouro, no diagnóstico da vaginose bacteriana (VB em gestantes assintomáticas e sintomáticas de baixo risco. MÉTODOS: Foi realizado um estudo de corte transversal em 321 grávidas, com idade gestacional entre 14ª e 26ª semanas, 218 assintomáticas e 103 com queixa de secreção vaginal sugestiva de vaginose bacteriana. Todas as gestantes foram avaliadas pelos critérios de Nugent e submetidas à pHmetria vaginal e ao teste do KOH a 10%. O coeficiente de Kappa foi utilizado para avaliar os métodos quanto à concordância diagnóstica. RESULTADO: A maioria das gestantes era adolescente (média etária 21,0±5,6 anos, nulípara e parda. A prevalência da vaginose bacteriana foi de 33,3% pelo método de pH e KOH e de 35,5% pelo Nugent. Entre as grávidas assintomáticas, foi observada ótima concordância dos métodos, com 72,5% delas apresentando resultados negativos para ambos os métodos, o que resultou em um elevado coeficiente de Kappa (k=0,82. No grupo de gestantes sintomáticas, houve 49,5% de positividade para ambos os métodos diagnósticos, demonstrando ótima concordância (k=0,74. CONCLUSÃO: A prevalência da vaginose bacteriana foi elevada tanto pelo método de pH e KOH quanto pelo Nugent. O método do pH e KOH é tão capaz em diagnosticar a vaginose bacteriana quanto os critérios de Nugent.PURPOSE: To assess the prevalence of bacterial vaginosis and to compare the accuracy of testing pH and KOH with the Nugent gradient, the gold standard for the diagnosis of bacterial vaginosis (BV in asymptomatic and symptomatic pregnant women at low risk. METHODS: We conducted a cross-sectional study on 321 pregnant women with gestational age between 14 and 26 weeks, 218 of them asymptomatic and 103 with vaginal complaints suggestive of bacterial vaginosis. All women were assessed by the

  7. Desempenho e atividade de amilase em tilápias-do-nilo submetidas a diferentes temperaturas Performance and amylase activity in Nile tilapia submitted to different temperatures

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    Guilherme de Souza Moura

    2007-11-01

    Full Text Available O objetivo deste trabalho foi avaliar o desempenho e a atividade de amilase em quimo de tilápias-do-nilo macho, linhagem tailandesa, submetidas a quatro diferentes temperaturas. O experimento foi conduzido em delineamento inteiramente casualizado, com quatro tratamentos (20, 24, 28 e 32ºC, seis repetições e dez peixes por unidade experimental. A dieta utilizada foi igual para todos os tratamentos. Aos 55 dias do experimento, o consumo de ração aparente, ganho de peso, conversão alimentar aparente, atividade de amilase e atividade específica da amilase foram avaliados. O consumo de ração aparente e o ganho de peso aumentaram linearmente com o aumento da temperatura. Na conversão alimentar aparente, foi observado efeito quadrático em função da temperatura com melhora na conversão de 1,79 a 1,00 com o aumento da temperatura até 29,15ºC. Observou-se efeito linear na atividade da amilase e na atividade específica da amilase em função da temperatura, com maior atividade de amilase e menor atividade específica de amilase a 32ºC. A temperatura da água influencia o desempenho e a atividade da amilase em tilápias-do-nilo.The objective of this work was to evaluate the performance and amylase activity in chime of Nile tilapia male, Thai line, submitted to four different temperatures. The experimental design was completely randomized with four treatments (20, 24, 28 and 32ºC, six replicates and ten fishes per experimental unit. The diet was the same for all treatments. At 55 days of experiment, apparent feed intake, weight gain, apparent feed conversion, amylase activity and specific amylase activity were evaluated. The apparent feed intake and weight gain increased linearly with temperature increase. For apparent feed conversion, quadratic effect was observed as a function of temperature, showing a conversion improvement of 1.79 to 1.00 with the increase of the temperature until 29,15ºC. Linear effect in amylase activity and

  8. E/M impedance modeling and experimentation for the piezoelectric wafer active sensor

    Science.gov (United States)

    Kamas, Tuncay; Giurgiutiu, Victor; Lin, Bin

    2015-11-01

    This study aimed to develop theoretical models to accurately predict the in-plane (longitudinal) and out-of-plane (thickness-wise) modes of the electromechanical impedance spectroscopy (EMIS) of a piezoelectric wafer active sensor (PWAS). Two main electrical assumptions are applied for both in-plane and thickness mode PWAS-EMIS in one-dimensional simplified analytical models. These assumptions are 1) constant electrical field assumption and 2) constant electrical displacement assumption. The analytical models with two assumptions are compared with one another to understand the prediction accuracy of the models in different vibration modes. Coupled field finite element analysis (CF-FEA) is also conducted with 2D PWAS model under stress-free boundary conditions. The simulations of the simplified analytical models for free PWAS-EMIS under these two assumptions are carried out. The analytical models are validated by corresponding finite element simulations as well as experimental measurements.

  9. Confidence scores for prediction models

    DEFF Research Database (Denmark)

    Gerds, Thomas Alexander; van de Wiel, MA

    2011-01-01

    modelling strategy is applied to different training sets. For each modelling strategy we estimate a confidence score based on the same repeated bootstraps. A new decomposition of the expected Brier score is obtained, as well as the estimates of population average confidence scores. The latter can be used...... to distinguish rival prediction models with similar prediction performances. Furthermore, on the subject level a confidence score may provide useful supplementary information for new patients who want to base a medical decision on predicted risk. The ideas are illustrated and discussed using data from cancer...

  10. Role of physical activity on the maintenance of cognition and activities of daily living in elderly with Alzheimer's disease Papel da atividade física na manutenção da cognição e atividades de vida diária em idosos com doença de Alzheimer

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    Cynthia Arcoverde

    2008-06-01

    Full Text Available BACKGROUND: The practice of physical activities has proved to be an efficient strategy in the improvement of independency and cognitive functions in the elderly with Alzheimer's disease (AD. OBJECTIVE: To evaluate the relation between the practice of physical activity, cognition and activities of daily living (ADL of patients with AD. METHOD: The cognitive and physical aspects and ADL were evaluated of 37 elders (19 normal controls, 11 sedentary with AD and 7 active with AD. RESULTS: The variable that best predicts the cognitive state (MMSE is the duration of disease for the AD sedentary group and Lawton's Scale for the AD active group. We observed a correlation between MMSE score and duration of disease in the sedentary group and between MMSE and ADL in the active group. CONCLUSION: Our study showed that physical and cognitive stimulation in patients with AD can contribute to decrease cognitive and functional decline.FUNDAMENTO: A prática de atividade física tem se mostrado uma estratégia eficaz na melhora da independência e das funções cognitivas em idosos com doença de Alzheimer (DA. OBJETIVO: Avaliar a relação entre a prática de atividade física, a cognição e as atividades de vida diária (AVD em pacientes com DA. MÉTODO: Foram avaliados os aspectos cognitivos, físicos e as AVD de 37 idosos (19 controles normais, 11 com DA sedentários e 7 com DA ativos. RESULTADOS: A variável que melhor prediz o estado cognitivo (MEEM foi o tempo de doença para o grupo DA sedentários e a Escala de Lawton para o grupo DA ativo. Observou-se correlação entre MEEM e tempo de doença no grupo sedentário e MEEM e AVD no grupo ativo. CONCLUSÃO: O nosso estudo mostrou que a estimulação física e cognitiva em pacientes com DA pode contribuir na diminuição do declínio cognitivo e funcional.

  11. Thermal effect on E/M impedance spectroscopy of piezoelectric wafer active sensors

    Science.gov (United States)

    Kamas, Tuncay; Frankforter, Erik; Yu, Lingyu Lucy; Lin, Bin; Giurgiutiu, Victor

    2015-03-01

    This paper presents theoretical predictive modeling and experimental evaluation of the structural health monitoring capability of piezoelectric wafer active sensors (PWAS) at elevated temperatures. Electromechanical impedance spectroscopy (EMIS) method is first qualified using circular PWAS resonators under traction-free boundary condition and in an ambience with increasing temperature. The theoretical study is conducted regarding temperature dependence of the electrical parameters, the capacitance C0, d31 and g31; and the elastic parameters, the in-plane compliance s11 and Young's modulus c11, of piezoelectric materials. The Curie transition temperature must be well above the operating temperature; otherwise, the piezoelectric material may depolarize under combined temperature and pressure conditions. The material degradation is investigated by introducing the temperature effects on the material parameters that are obtained from experimental observations as well as from related work in literature. The preliminary results from the analytical 2-D circular PWAS-EMIS simulations are presented and validated by the experimental PWAS-EMIS measurements at elevated temperatures. Temperature variation may produce pyro-electric charges, which may interfere with the piezoelectric effect. Therefore, analytical simulations are carried out to simulate the pyro-electric response from the temperature effects on a free circular PWAS-EMIS in in-plane mode. For the experimental validation, PWAS transducers are placed in a fixture that provides the traction-free boundary condition. The fixture is then located in an oven integrated with PID temperature controller. The EMIS measurement is conducted during the temperature increase and the first resonance frequency peak in admittance and impedance spectra was acquired.

  12. Estimativas de correlações genéticas entre escores visuais e características de carcaça medidas por ultrassonografia em bovinos Nelore utilizando modelos bayesianos linear-limiar Genetic correlation estimates between visual scores and carcass traits measured by ultrasound in Nelore cattle using linear-threshold bayesian models

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    Carina Ubirajara de Faria

    2009-11-01

    Full Text Available O objetivo neste estudo foi estimar as correlações genéticas entre escores visuais e características de carcaça medidas por ultrassonografia em bovinos da raça Nelore utilizando a estatística bayesiana por meio da Amostragem de Gibbs, sob modelo animal linear-limiar. Foram estudadas as características categóricas morfológicas de musculosidade, estrutura física, conformação e sacro, avaliadas aos 15 e 22 meses de idade. Para as características de carcaça, foram avaliadas as características área de olho-de-lombo, espessura de gordura subcutânea, espessura de gordura subcutânea na garupa e altura na garupa. Os escores visuais devem ser empregados como critérios de seleção para aumentar o progresso genético para a característica área de olhode-lombo e, consequentemente, melhorar o rendimento de carcaça. As estimativas de correlação genética obtidas para musculosidade com espessura de gordura subcutânea e espessura de gordura subcutânea na garupa indicaram que a seleção para musculosidade pode levar a animais com melhor acabamento de carcaça. A seleção para a estrutura física e conformação aos 15 e 22 meses de idade pode promover resposta correlacionada para o aumento da altura na garupa.The objective of this study was to estimate the genetic correlations between visual scores and the carcass traits measured by ultrasound, in Nellore breed cattle, using the bayesian statistics by Gibbs Sampling, in the linear-threshold model. The morphological categorical traits of musculature, physical structure, conformation and sacrum were studied, evaluated at 15 and 22 months. The carcass traits of the longissimus muscle area, backfat thickness, rump fat thickness and hip height were evaluated. Visual scores should be used as selection criterion to increase genetic progress for the longissumus muscle area. The estimates of genetic correlations obtained between musculature and backfat thickness and rump fat thickness

  13. Modelling sequentially scored item responses

    NARCIS (Netherlands)

    Akkermans, W.

    2000-01-01

    The sequential model can be used to describe the variable resulting from a sequential scoring process. In this paper two more item response models are investigated with respect to their suitability for sequential scoring: the partial credit model and the graded response model. The investigation is c

  14. Skyrocketing Scores: An Urban Legend

    Science.gov (United States)

    Krashen, Stephen

    2005-01-01

    A new urban legend claims, "As a result of the state dropping bilingual education, test scores in California skyrocketed." Krashen disputes this theory, pointing out that other factors offer more logical explanations of California's recent improvements in SAT-9 scores. He discusses research on the effects of California's Proposition 227,…

  15. The Machine Scoring of Writing

    Science.gov (United States)

    McCurry, Doug

    2010-01-01

    This article provides an introduction to the kind of computer software that is used to score student writing in some high stakes testing programs, and that is being promoted as a teaching and learning tool to schools. It sketches the state of play with machines for the scoring of writing, and describes how these machines work and what they do.…

  16. Trends in Classroom Observation Scores

    Science.gov (United States)

    Casabianca, Jodi M.; Lockwood, J. R.; McCaffrey, Daniel F.

    2015-01-01

    Observations and ratings of classroom teaching and interactions collected over time are susceptible to trends in both the quality of instruction and rater behavior. These trends have potential implications for inferences about teaching and for study design. We use scores on the Classroom Assessment Scoring System-Secondary (CLASS-S) protocol from…

  17. Classification of current scoring functions.

    Science.gov (United States)

    Liu, Jie; Wang, Renxiao

    2015-03-23

    Scoring functions are a class of computational methods widely applied in structure-based drug design for evaluating protein-ligand interactions. Dozens of scoring functions have been published since the early 1990s. In literature, scoring functions are typically classified as force-field-based, empirical, and knowledge-based. This classification scheme has been quoted for more than a decade and is still repeatedly quoted by some recent publications. Unfortunately, it does not reflect the recent progress in this field. Besides, the naming convention used for describing different types of scoring functions has been somewhat jumbled in literature, which could be confusing for newcomers to this field. Here, we express our viewpoint on an up-to-date classification scheme and appropriate naming convention for current scoring functions. We propose that they can be classified into physics-based methods, empirical scoring functions, knowledge-based potentials, and descriptor-based scoring functions. We also outline the major difference and connections between different categories of scoring functions.

  18. D-score: a search engine independent MD-score.

    Science.gov (United States)

    Vaudel, Marc; Breiter, Daniela; Beck, Florian; Rahnenführer, Jörg; Martens, Lennart; Zahedi, René P

    2013-03-01

    While peptides carrying PTMs are routinely identified in gel-free MS, the localization of the PTMs onto the peptide sequences remains challenging. Search engine scores of secondary peptide matches have been used in different approaches in order to infer the quality of site inference, by penalizing the localization whenever the search engine similarly scored two candidate peptides with different site assignments. In the present work, we show how the estimation of posterior error probabilities for peptide candidates allows the estimation of a PTM score called the D-score, for multiple search engine studies. We demonstrate the applicability of this score to three popular search engines: Mascot, OMSSA, and X!Tandem, and evaluate its performance using an already published high resolution data set of synthetic phosphopeptides. For those peptides with phosphorylation site inference uncertainty, the number of spectrum matches with correctly localized phosphorylation increased by up to 25.7% when compared to using Mascot alone, although the actual increase depended on the fragmentation method used. Since this method relies only on search engine scores, it can be readily applied to the scoring of the localization of virtually any modification at no additional experimental or in silico cost.

  19. Efeito do cobre na atividade da enzima pirogalol peroxidase em plantas de Myriophyllum aquaticum cultivadas em solução nutritiva Effect of copper on the activity of pirogalol peroxidase in Myriophyllum aquaticum plants cultivated in nutritives solution

    Directory of Open Access Journals (Sweden)

    V.D. Domingos

    2005-06-01

    Full Text Available Myriophyllum aquaticum é uma planta perene, herbácea, que pode se desenvolver totalmente submersa ou com a porção terminal dos ramos acima da superfície da água. É também considerada uma planta daninha que possui elevado potencial de colonização, o qual, dependendo da densidade populacional, pode causar aumento no teor de matéria orgânica e redução de oxigênio na água, comprometendo a qualidade da água e seus usos múltiplos. O objetivo do presente trabalho foi verificar a influência do cobre na atividade da pirogalol peroxidase de plantas de M. aquaticum submetidas à solução nutritiva contendo concentrações de cobre de 1,2; 11,2; 21,2; 31,2; e 41,2 µg L-1. O experimento foi conduzido em um delineamento experimental inteiramente casualizado, com quatro repetições e cinco tratamentos, aos quais as plantas foram submetidas durante 21 dias. Aos 81 dias após a instalação das mudas em solução nutritiva contendo os diferentes níveis de cobre, as folhas foram colhidas a partir do ápice da planta até o final do ramo, que não estavam em contato com a solução. Esse material fresco foi envolvido por plástico transparente e papel-alumínio e, a seguir, congelado em nitrogênio líquido, sendo armazenado em freezer a -20 ºC até o momento da determinação da atividade da enzima pirogalol peroxidase. A atividade da enzima foi progressiva com o aumento das doses de cobre. As plantas cultivadas com 40 µg L-1 de Cu2+ após três semanas, com base em avaliação visual, apresentaram redução no desenvolvimento.Myriophyllum aquaticum is a perennial, herbaceous plant which grows totally submerged or with the terminal portion of the branches above the surface of the water. It is also considered to be a harmful plant, possessing a high colonization potential which, depending on population density, can increase the organic matter content and reduce oxygen in the water, compromising the quality of water and its multiple uses

  20. Freqüência da atividade sexual em mulheres menopausadas Factors related to frequency of sexual activity of postmenopausal women

    Directory of Open Access Journals (Sweden)

    Dino Roberto Soares De Lorenzi

    2006-08-01

    Full Text Available OBJETIVO: Identificar os fatores relacionados à freqüência da atividade sexual entre mulheres pós-menopáusicas. MÉTODOS: Estudo transversal de 206 mulheres pós-menopáusicas entre 45 e 60 anos atendidas em um serviço universitário da região Sul do Brasil entre junho e outubro de 2002. A atividade sexual foi avaliada pelo número de relações sexuais no último mês e a sintomatologia climatérica pelo Índice de Kupperman. Na análise estatística, fez-se regressão linear múltipla. RESULTADOS: Das mulheres pesquisadas, 176 (85% eram sexualmente ativas. Cerca de 60,6% relataram diminuição da atividade sexual após a menopausa, o que atribuíram principalmente à impotência sexual do parceiro (41,7%. Aproximadamente 25,7% negaram satisfação com o intercurso sexual. Na análise por regressão linear múltipla, associaram-se à atividade sexual a idade (pOBJECTIVE: To identify factors related to the frequency of sexual activity of postmenopausal women METHODS: A cross-section study of 206 postmenopausal women between 45 and 60 years of age was made at a university health care service in the South of Brazil between June and October 2002. Evaluations were made of sexual activity according to the number of sexual intercourses in the previous month and the climacteric symptoms using the Kupperman index. Statistical analysis was performed with multiple linear regression analysis. RESULTS: Of those surveyed 176 (85% women were sexually active. Although 60.6% reported a decrease in sexual activity after menopause, mostly attributing it to the husband's sexual impotence (41.7%. Approximately 25.7% stated they had no satisfaction with sexual intercourse. By means of multiple linear regression analysis the following aspects were associated to sexual activity: age (p<0.1, degree of sexual satisfaction (p=0.01, and climacteric symptomatology (p=0.02. As age increased the climacteric symptoms were more intense and sexual activity was less

  1. Ultra-high Resolution Mapping of the Inner Crater of the Active Kick'em Jenny Volcano

    Science.gov (United States)

    Hart, L.; Scott, C.; Tominaga, M.; Smart, C.; Vaughn, I.; Roman, C.; Carey, S.; German, C. R.; Participants, T.

    2015-12-01

    We conducted high-resolution geological characterization of a 0.015km^2 region of the inner crater of the most active submarine volcano in the Caribbean, Kick'em Jenny, located 8 km off Grenada in the Lesser Antilles Island Arc. We obtained digital still images and microbathymetery at an altitude of 3 m from the seafloor by using stereo cameras and a BlueView system mounted on Remotely Operated Vehicle (ROV) Hercules during the NA054 cruise on E/V Nautilus (Sept. - Oct. 2014). The seafloor images were processed to construct 2-D photo mosaics of the survey area using Standard Hercules Imaging Suite. We systematically classified the photographed seafloor geology based on the distribution of seafloor morphology and the observable rock fragment and outcrop sizes. The center of the crater floor shows a smooth, coherent texture with little variation in sea floor morphology. From immediately outside this area toward the crater rim, we observe an extensive area covered with outcrops, small rocks, and sediment: and within this area, (1) the north section is partially covered by uneven outcrops with elongated lineaments and a course, rugged seafloor with individual rock fragments observable; (2) the middle section contains high variability and heterogeneity in seafloor morphology in a non-systematic manner; and (3) overall, the southern most section displays subdued seafloor features both in space and variability compared to the other areas. The distributions of rock fragments were classified into four distinct sizes. We observe: (i) little variation in size distribution near the center of the crater floor; and (ii) rock fragment size increasing toward the rim of the crater. To obtain a better understanding of the link between variation in seafloor morphology, rock size distribution, and other in situ processes, we compare our observations on the digital photo mosaic to bathymetry data and ROV visuals (e.g. vents and bacterial mats).

  2. Synthesis of 1,2,3-Triazole Derivatives and <em>in Vitroem> Antifungal Evaluation on <em>Candida> Strains

    Directory of Open Access Journals (Sweden)

    Almir G. Wanderley

    2012-05-01

    Full Text Available 1,2,3-Triazoles have been extensively studied as compounds possessing important biological activities. In this work, we describe the synthesis of ten 2-(1-aryl-1<em>H>-1,2,3-triazol-4-ylpropan-2-ols via copper catalyzed azide alkyne cycloaddition (CuAAc or <em>click chemistryem>. Next the<em> in vitroem> antifungal activity of these ten compounds was evaluated using the microdilution broth method against 42 isolates of four different <em>Candida> species. Among all tested compounds, the halogen substituted triazole 2-[1-(4-chlorophenyl-1<em>H>-(1,2,3triazol-4-yl]propan-2-ol, revealed the best antifungal profile, showing that further modifications could be done in the structure to obtain a better drug candidate in the future.

  3. Pontas evocadas por estímulos somatossensitivos e atividade epileptiforme no eletrencefalograma em crianças "normais" Somatosensory evoked spikes and epileptiform activity in "normal" children

    Directory of Open Access Journals (Sweden)

    Lineu C. Fonseca

    2003-09-01

    Full Text Available Estudamos a ocorrência de potenciais de alta voltagem evocados por estímulos somatossensitivos - pontas evocadas (PE - e de atividade epileptiforme espontânea (AE no EEG de 173 crianças normais de 7 a 11 anos de idade. Durante o EEG, dez percussões foram realizadas nas mãos e pés. Foi avaliada a ocorrência de PE acompanhando cada um dos estímulos e a presença de AE. AE foi observada em quatro crianças (2,3%: pontas centroparietais em duas, complexos de ponta-onda lenta generalizados em uma e pontas parietais e temporais médias em uma. Uma menina de 10 anos de idade (0,58% teve ao EEG pontas parietais medianas evocadas pela percussão do pé esquerdo. Este EEG era normal quanto a outros aspectos. Nossos achados de AE em crianças normais são similares aos encontrados em estudos de outros países. Constatamos que espículas somatossensitivas podem ser observadas em crianças normais o que sugere uma natureza funcional ligada à idade.Little is known about somatosensory evoked spikes (SES in the EEG of normal children. We studied the occurrence of SES and spontaneous epileptiform activity (SEA in 173 normal children ageg 7 to 11 years. During the EEG ten taps were applied to both hands and feet. The occurrence of high voltage potentials evoked by each stimulation of one or both heels or hands (SES and the occurrence of SEA were evaluated. SEA was observed in four children (2.3 %: central/parietal spikes in two cases, generalized spike-and-wave in one, and parietal/midtemporal spikes in one case. A ten years old girl (0,58% had SES on median parietal region by tapping the left foot. This EEG was otherwise normal. Our findings of SEA are similar to those obtained in other normal populations. SES can be observed in normal children. These SES suggest that we are dealing with an age-related functional phenomenon.

  4. Influência da condição corporal e da concentração de energia nas dietas no periparto sobre o desempenho de cabras em lactação Body condition score and peripartum energy density on performance of dairy goats

    Directory of Open Access Journals (Sweden)

    Carla Aparecida Florentino Rodrigues

    2006-08-01

    Full Text Available Este trabalho foi realizado com o objetivo de avaliar os efeitos da interação nível de energia líquida (EL nas dietas × condição corporal (CC no periparto sobre o desempenho de cabras nos primeiros 60 dias da lactação e as concentrações plasmáticas de ácidos graxos não-esterificados (AGNE no pós-parto. Os animais foram distribuídos em delineamento inteiramente casualizado, em esquema fatorial 2 x 3 x 2 com quatro repetições, composto de duas condições corporais, três níveis de EL (baixo, médio, alto na dieta no pré-parto e dois níveis de EL (médio, alto no pós-parto. Inicialmente, os animais foram separados em dois grupos, de acordo com a CC, adotando-se o valor de 3,25 como mediano. Dietas no pré e no pós-parto foram isoprotéicas, com 13 e 16% de PB, respectivamente. No período pré-parto, os níveis de energia das dietas foram 1,1; 1,4 e 1,6 Mcal de EL/kg de MS e, no período pós-parto, de 1,4 e 1,6 Mcal de EL/kg de MS. A interação CC × níveis de EL no pós-parto influenciou o consumo de FDN, de modo que cabras com menor CC consumiram mais fibra (FDN com a redução da concentração de EL nas dietas. Os níveis de EL fornecidos durante o pós-parto influenciaram o consumo de nutrientes e a produção de leite, pois a presença de níveis elevados de FDN na dieta com 1,4 Mcal EL/kg MS limitou a expressão do potencial produtivo dos animais. Não foram observados efeitos das CC e dos níveis de EL nas dietas sobre a concentração plasmática de AGNE no pós-parto, indicando pequena mobilização de reservas de lipídios do tecido adiposo.The objective of this trial was to evaluate the effect of body condition score (BCS and different dietary net energy (NE levels during prepartum on performance and concentration of plasma non-esterified fatty acids (NEFA in early lactating dairy goats. Animals (four replicates per treatment were assigned to a completely randomized design in a 2 x 3 x 2 factorial arrangement

  5. Carga de trabalho de enfermagem em unidades de terapia intensiva publicas e privadas

    Directory of Open Access Journals (Sweden)

    Lilia de Souza Nogueira

    2013-09-01

    Full Text Available OBJETIVO: Comparar pacientes de unidades de terapia intensiva públicas e privadas segundo carga de trabalho e intervenções de enfermagem. MÉTODOS: Estudo comparativo, tipo coorte retrospectivo, com 600 pacientes internados em 4 unidades de terapia intensiva localizadas em São Paulo. A carga de trabalho e as intervenções de enfermagem foram identificadas pelo Nursing Activities Score nas primeiras e últimas 24 horas de permanência do paciente na unidade de terapia intensiva. Os testes do qui-quadrado de Pearson, exato de Fisher, t de Student e Mann-Whitney foram utilizados na comparação dos grupos. RESULTADOS: A média do Nursing Activities Score calculado na admissão da unidades de terapia intensiva foi 61,9 e, na saída, de 52,8. Diferenças significativas foram encontradas entre os pacientes admitidos nas unidades de terapia intensiva públicas e privadas em relação ao Nursing Activities Score médio na admissão e em 12 das 23 intervenções de enfermagem realizadas nas primeiras 24 horas de internação na unidade crítica. Os pacientes internados nas unidades de terapia intensiva públicas apresentaram maior valor médio do escore e, em geral, tiveram maior frequência de intervenções, exceto àquelas relacionadas a "cuidados com drenos", "mobilização e posicionamento", e "hiperalimentação intravenosa". Os grupos também diferiram em relação à evolução do Nursing Activities Score entre admissão e saída da unidade de terapia intensiva na casuística total e entre os sobreviventes. CONCLUSÃO: Pacientes internados em unidades de terapia intensiva públicas e privadas apresentam particularidades em relação à demanda de cuidados requerida e tal achado pode subsidiar os gestores na busca de um adequado dimensionamento da equipe de enfermagem.

  6. Determinação de escore e nota de corte do módulo de asma do International Study of Asthma and Allergies in Childhood para discriminação de adultos asmáticos em estudos epidemiológicos Determining the score and cut-off point that would identify asthmatic adults in epidemiological studies using the asthma module of the International Study of Asthma and Allergies in Childhood questionnaire

    Directory of Open Access Journals (Sweden)

    Elayne de Fátima Maçãira

    2005-12-01

    Full Text Available OBJETIVO: Validar o questionário padronizado escrito do International Study of Asthma and Allergies in Childhood, módulo sobre asma, para pesquisa de prevalência de asma, estabelecendo seu escore e a nota de corte para discriminação de adultos asmáticos. MÉTODOS: Entrevistamos pacientes ambulatoriais adultos, 40 asmáticos e 38 controles, pareados por sexo e idade, utilizando o módulo de asma do International Study of Asthma and Allergies in Childhood, composto por oito aspectos dicotômicos de asma. Determinamos o escore e a nota de corte para discriminação de asmáticos, definindo sua sensibilidade, especificidade e índice de Youden. Validamos o método em contraposição ao diagnóstico clínico e funcional. A reprodutibilidade das questões individuais foi testada por meio de reentrevistas de metade dos pacientes após algumas semanas. RESULTADOS: O escore variou de 0 a 14 pontos. Um escore = 5 pontos permitiu discriminar pacientes asmáticos (sensibilidade = 93%, especificidade = 100% e índice de Youden = 0,93. A maioria das questões apresentou boa reprodutibilidade, observada em reentrevista após 48,2 ± 11,1 dias (Kappa e Kappa ponderado variando de 0,43 a 1,00 para as questões individuais. CONCLUSÃO: A validação de uma nota de corte permite uma interpretação alternativa às informações fornecidas pelo módulo de asma do International Study of Asthma and Allergies in Childhood, levando em conta o conjunto das informações e não somente as respostas individuais de cada questão em estudos de prevalência de asma em adultos.OBJECTIVE: To validate, for use in asthma prevalence studies, the asthma module of the standardized written questionnaire developed for use in the International Study of Asthma and Allergies in Childhood, establishing the score and cut-off point that would identify asthmatic adults. METHODS: We interviewed 78 adult outpatients (40 adult asthmatics and 38 age-matched and gender-matched controls

  7. Two New Compounds Isolated from<em> Liriope muscariem>

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    Rui-Chao Lin

    2012-07-01

    Full Text Available Two new compounds, (2<em>S>,3<em>R>-methyl 7-hydroxy-2-(4-hydroxy-3-methoxy-phenyl-3-(hydroxymethyl-2,3-dihydrobenzofuran-5-carboxylate (1 and (4<em>R,>5<em>S>-5-(3-hydroxy-2,6-dimethylphenyl-4-isopropyldihydrofuran-2-one (2, tentatively named norcurlignan and limlactone, respectively, were isolated from <em>Liriope muscariem>, together with the known compound (−-pinoresinol (3. The structures of these compounds were elucidated and characterized on the basis of 1D NMR, 2D NMR, CD and MS data. The <em>in vitroem> antioxidant activities of compounds 13 were assessed by the DPPH and ABTS scavenging methods.

  8. ACCUMULATION OF NITROGEN COMPOUNDS AND NITRATE REDUCTASE ACTIVITY IN LETTUCE CULTIVATED IN DIFFERENT CROP SYSTEMS ACÚMULO DE COMPOSTOS NITROGENADOS E ATIVIDADE DA REDUTASE DO NITRATO EM ALFACE PRODUZIDA EM DIFERENTES SISTEMAS DE CULTIVO

    Directory of Open Access Journals (Sweden)

    Fernanda Nunes Ibrahim

    2008-09-01

    Full Text Available

    Nitrate content determination is important for food quality evaluation, therefore when ingested nitrate is reduced the nitrite, which can generate harmful compounds to the human organism. Ahead of this, the present work had as objective to study the transport and accumulation of nitrogen compounds and the nitrate reductase activity in lettuce cultivar 'Vera' produced in Registro (SP in different cropping systems. Were collected samples of the xylem sap, aerial part and root for quantification of nitrogen compounds and of the reductase activity <em>in vivoem>. The nitrate concentration in the xylem sap, the nitrate and amino acids contents, as well as the nitrate reductase activity, demonstrated more intense transport, accumulation and assimilation in plants cultivated in in hydroponic solution, followed of the conventional system and finally, of the organic. The stem of the plant in the three systems of culture presented high capacity of accumulation and assimilation the nitrogen compounds. The nitrate reductase activity in leaves was superior of the root. The content nitrate, independent of the culture system, varied of 24.32 the 800.06 mg kg-1 of FW in the different parts of the plant. However, it did not exceed the maximum

  9. Foliar application of chlorocholine chloride improves leaf mineral nutrition, antioxidant enzyme activity, and tuber yield of potato (<em>Solanum tuberosumem> L.)

    DEFF Research Database (Denmark)

    Wang, Huigun; Xiao, Langtao; Tong, Jianhua;

    2010-01-01

    activity. Results showed that 1.5 and 2.0 g l-1 CCC treatments significantly increased the contents of P, K, Ca, Mg, Fe, Mn, Zn and Cu in potato leaves. These treatments also increased superoxide dismutase (SOD), peroxidases (POD) and catalase (CAT) activities in the leaves. A positive linear relationship...

  10. Atividade microbiana, carbono e nitrogênio da biomassa microbiana em plantações de eucalipto, em seqüência de idades Activity, carbon and nitrogen of microbial biomass in eucalypt plantations in an age sequence

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    Patrícia Anjos Bittencourt Barreto

    2008-04-01

    Full Text Available Em plantações florestais, a atividade microbiana tem grande relevância para a ciclagem de nutrientes e a fertilidade do solo, uma vez que esses ecossistemas, devido a seus característicos longos períodos de rotação, proporcionam um contínuo aporte de serapilheira e morte de raízes, que contribuem para a manutenção e elevação do teor de matéria orgânica do solo. O objetivo deste trabalho foi caracterizar a atividade e a biomassa microbiana em solos sob plantações de eucalipto em distintas idades de cultivo. Foram avaliadas alterações na biomassa e atividade microbiana em solo e serapilheira de plantações de eucalipto com 1, 3, 5 e 13 anos de idade crescendo sob condições edafoclimáticas semelhantes. Encontraram-se maiores teores de C e N microbiano da serapilheira do que no solo, sugerindo que a serapilheira seria uma importante reserva de C e N microbiano em povoamentos de eucalipto. Não se verificou tendência de aumento ou diminuição da biomassa e da atividade microbiana com as idades das plantações, o que, provavelmente, decorreu do fato dos povoamentos estudados corresponderem a áreas de reforma. A qualidade orgânica da serapilheira influenciou diretamente a atividade, o C e N da biomassa microbiana da serapilheira. Os indicadores mais sensíveis para aferir variações dos solos das plantações de eucalipto foram os teores de C orgânico e N total, e na serapilheira foram os atributos microbianos, os teores de celulose, lignina e N.Microbial activity is highly relevant for nutrient cycling and soil fertility in forest plantations. Due to the long growth cycles, continuous litter production and dead roots contribute to storage and increase of soil organic matter. Changes in soil and litter microbial biomass and activity under 1, 3, 5 and 13-year-old eucalypt plantations were evaluated. Soil and climate conditions were the same at the sites. Microbial biomass C and N were higher in litter than in soil. Then

  11. Atributos químicos e atividade microbiana em solos convertidos de savana para plantios de Acacia mangium Willd em Roraima. = Chemical attribuites and microbial activity in soils converted to savanna for plantations of Acacia mangium Willd. in Roraima, Brazil.

    Directory of Open Access Journals (Sweden)

    Moisés Mourão Júnior

    2011-04-01

    Full Text Available A atividade microbiana tem sido empregada na avaliação de solos manejados, sendo um indicador importante na caracterização de solos alterados. Nesse sentido, objetivou-se com o presente trabalho avaliar o efeito de plantios de Acacia mangium com diferentes idades sobre os atributos químicos e atividade microbiana em solos representativos da Savana do Estado de Roraima. Os plantios de A. mangium de três e cinco anos encontravam-se em áreas de LATOSSOLO AMARELO Distrófico e os de quatro e seis anos em ARGISSOLO AMARELO Distrófico. As áreas próximas aos plantios com as mesmas condições de solos e com cobertura vegetal primária (savana natural constituiram as testemunhas. Foram amostrados os horizontes A e B sendo avaliados os atributos químicos dos solos e a atividade microbiana. A pobreza química e elevadasaturação por alumínio (%m dos solos estudados influenciaram significativamente nos menores valores de C-CO2 evoluído pela atividade microbiana. A maior atividade microbiana ocorreu em áreas plantadas independentemente do tipo de solo, em função das melhores condições químicas. Os maiores valores de C-CO2 evoluído correlacionaram-se melhor com os teores de carbono orgânico e matéria orgânica do solo. = Microbial activity has been used in the evaluation of soils, an important indicator in the characterization of alteredsoils. Therefore, this study has as aim to evaluate the effect of replacing natural vegetation to plantations of Acacia mangium onmicrobial activity in soils of savannas in Roraima state. The areas studied consisted of plantations of acacia with three and fiveyears in Yellow Latosol with four and six years in yellow Alfisols. Areas near the plantations with the same conditions of soiland vegetation (natural savanna were considered control. Were sampled the A and B horizons, corresponding depths 0-30 and 30-60 cm respectively, with three replications for a total of 36 experimental units. The results

  12. Hypolipidemic activity of Moringa oleifera Lam., Moringaceae, on high fat diet induced hyperlipidemia in albino rats Atividade hipolipidemica de Moringa oleifera Lam., Moringaceae, na hiperlipidemia induzida por dieta rica em gordura em ratos albinos

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    Pankaj G. Jain

    2010-12-01

    Full Text Available The leaves of Moringa oleifera Lam., Moringaceae, are used by the Indians in their herbal medicine as a hypolipidemic agent in obese patients. Albino Wistar rats were fed with methanolic extract of M. oleifera (150, 300 and 600 mg/kg, p.o. and simvastatin (4 mg/kg, p.o. along with hyperlipidemic diet for 30 days. Moringa oleifera and simvastatin were found to lower the serum cholesterol, triacylglyceride, VLDL, LDL, and atherogenic index, but were found to increase the HDL as compared to the corresponding high fed cholesterol diet group (control. The Moringa oleifera methanolic extract was also investigated for its mechanism of action by estimating HMG CO-A reductase activity. Moringa oleifera was found to increase the excretion of fecal cholesterol. Thus, the study demonstrates that M. oleifera possesses a hypolipidemic effect.As folhas de Moringa oleifera Lam., Moringaceae, são usados na medicina natural da Índia como um agente hipolipemiante em pacientes obesos. Ratos albinos Wistar foram alimentados com extrato metanólico de M. oleifera (150, 300 e 600 mg/kg, p.o. e sinvastatina (4 mg/kg, p.o., juntamente com dieta hiperlipídica por 30 dias. Moringa oleifera e sinvastatina reduziram o colesterol, triacilglicerídeoss, VLDL, LDL e índice aterogênico, mas não aumentaram o HDL em comparação com o grupo controle, com dieta rica em colesterol. O mecanismo de ação do extrato metanólico de Moringa oleifera foi também investigado estimando atividade de HMG CO-A redutase. Moringa oleifera aumentou a excreção fecal de colesterol. Assim, o estudo demonstra que a M. oleifera parece ter efeito hipolipemiante.

  13. Rationale and study protocol for the supporting children’s outcomes using rewards, exercise and skills (SCORES group randomized controlled trial: A physical activity and fundamental movement skills intervention for primary schools in low-income communities

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    Lubans David R

    2012-06-01

    Full Text Available Abstract Background Many Australian children are insufficiently active to accrue health benefits and physical activity (PA levels are consistently lower among youth of low socio-economic position. PA levels decline dramatically during adolescence and evidence suggests that competency in a range of fundamental movement skills (FMS may serve as a protective factor against this trend. Methods/design The Supporting Children’s Outcomes Using Rewards Exercise and Skills (SCORES intervention is a multi-component PA and FMS intervention for primary schools in low-income communities, which will be evaluated using a group randomized controlled trial. The socio-ecological model provided a framework for the 12-month intervention, which includes the following components: teacher professional learning, student leadership workshops (including leadership accreditation and rewards, e.g., stickers, water bottles, PA policy review, PA equipment packs, parental engagement via newsletters, FMS homework and a parent evening, and community partnerships with local sporting organizations. Outcomes will be assessed at baseline, 6- and 12-months. The primary outcomes are PA (accelerometers, FMS (Test of Gross Motor Development II and cardiorespiratory fitness (multi-stage fitness test. Secondary outcomes include body mass index [using weight (kg/height (m2], perceived competence, physical self-esteem, and resilience. Individual and environmental mediators of behavior change (e.g. social support and enjoyment will also be assessed. The System for Observing Fitness Instruction Time will be used to assess the impact of the intervention on PA within physical education lessons. Statistical analyses will follow intention-to-treat principles and hypothesized mediators of PA behavior change will be explored. Discussion SCORES is an innovative primary school-based PA and FMS intervention designed to support students attending schools in low-income communities to be more skilled

  14. Correlation of signal intensity ratio on orbital MRI-TIRM and clinical activity score as a possible predictor of therapy response in Graves' orbitopathy - a pilot study at 1.5 T

    Energy Technology Data Exchange (ETDEWEB)

    Kirsch, Eberhard C.; Kaim, Achim H. [Hirslanden Clinic Aarau, Neuroradiology and Cranio-Facial-Center Hirslanden, Aarau (Switzerland); Oliveira, Marion Gregorio de [University Eye Clinic Basel, Basel (Switzerland); Arx, Georg von [basedow.ch, Interdiscipinary Centre for Graves' Orbitopathy, Olten (Switzerland)

    2010-02-15

    This study seeks to describe the predictive value of the signal intensity ratio (SIR) in magnetic resonance imaging-turbo inversion recovery magnitude (MRI-TIRM) in patients with Graves' orbitopathy (GO) with regard to predictability of therapy response. Included in this prospective pilot study were 36 consecutive patients with GO and 25 control subjects. Patients were clinically assessed according to the European Group on Graves' Orbitopathy recommendations with active GO defined by a clinical activity score (CAS) {>=} 3. On magnetic resonance (MR) imaging, muscle inflammation was measured with a region of interest set within the brightest extra-ocular muscle both on coronal turbo inversion recovery magnitude (TIRM) and on fat suppressed gadolinium-enhanced T1-weighted sequences. To calculate the SIR, the measured signal intensity was set in proportion to that of the ipsilateral temporalis muscle. Signal intensity ratio in coronal T2-weighted TIRM sequences in either group ranged from 1.22 to 4.92 (mean 2.04) in patients with GO and from 1.18 to 2.4 (mean 1.63) in controls without GO. The observed differences were significant on the TIRM sequences (right eye p = 0.023; left eye p = 0.022), whereas, no significant differences could be detected on the T1-weighted sequences (right eye p = 0.396; left eye p = 0.498). A cut off value of SIR > 2.5 for a CAS {>=} 4 to discriminate active from inactive patients was statistically calculated. T2 relaxation time is a reliable tool in detecting active GO. The difference in T2-SIR versus T1-SIR is helpful to distinguish inflammatory oedema of the extra ocular muscles from intra-orbital congestion due to reduced venous outflow. (orig.)

  15. Protease activity of legumain is inhibited by an increase of cystatin E/M in the DJ-1-knockout mouse spleen, cerebrum and heart

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    Takuya Yamane

    2017-03-01

    Full Text Available Legumain (EC 3.4.22.34 is an asparaginyl endopeptidase. Legumain activity has been detected in various mouse tissues including the kidney, spleen and epididymis. Legumain is overexpressed in the majority of human solid tumors and transcription of the legumain gene is regulated by the p53 tumor suppressor in HCT116 cells. The legumain activity is also increased under acid conditions in Alzheimer's disease brains. DJ-1/PARK7, a cancer- and Parkinson's disease-associated protein, works as a coactivator to various transcription factors, including the androgen receptor, p53, PSF, Nrf2, SREBP and RREB1. Recently, we found that legumain expression, activation and cleavage of annexin A2 are regulated by DJ-1 through p53. In this study, we found that the expression levels of legumain mRNA were increased in the cerebrum, kidney, spleen, heart, lung, epididymis, stomach, small intestine and pancreas from DJ-1-knockout mice, although legumain activity levels were decreased in the cerebrum, spleen and heart from DJ-1-knockout mice. Furthermore, we found that cystatin E/M expression was increased in the spleen, cerebrum and heart from DJ-1-knockout mice. These results suggest that reduction of legumain activity is caused by an increase of cystatin E/M expression in the spleen, cerebrum and heart from DJ-1-knockout mice.

  16. What Is the Apgar Score?

    Science.gov (United States)

    ... Development Infections Diseases & Conditions Pregnancy & Baby Nutrition & Fitness Emotions & Behavior School & Family Life First Aid & Safety Doctors & ... 2 being the best score: A ppearance (skin color) P ulse (heart rate) G rimace response (reflexes) ...

  17. Obstetrical disseminated intravascular coagulation score.

    Science.gov (United States)

    Kobayashi, Takao

    2014-06-01

    Obstetrical disseminated intravascular coagulation (DIC) is usually a very acute, serious complication of pregnancy. The obstetrical DIC score helps with making a prompt diagnosis and starting treatment early. This DIC score, in which higher scores are given for clinical parameters rather than for laboratory parameters, has three components: (i) the underlying diseases; (ii) the clinical symptoms; and (iii) the laboratory findings (coagulation tests). It is justifiably appropriate to initiate therapy for DIC when the obstetrical DIC score reaches 8 points or more before obtaining the results of coagulation tests. Improvement of blood coagulation tests and clinical symptoms are essential to the efficacy evaluation for treatment after a diagnosis of obstetrical DIC. Therefore, the efficacy evaluation criteria for obstetrical DIC are also defined to enable follow-up of the clinical efficacy of DIC therapy.

  18. From Rasch scores to regression

    DEFF Research Database (Denmark)

    Christensen, Karl Bang

    2006-01-01

    Rasch models provide a framework for measurement and modelling latent variables. Having measured a latent variable in a population a comparison of groups will often be of interest. For this purpose the use of observed raw scores will often be inadequate because these lack interval scale propertie....... This paper compares two approaches to group comparison: linear regression models using estimated person locations as outcome variables and latent regression models based on the distribution of the score....

  19. A pesquisa em cognição e as atividades escolares de leitura Research on cognition and reading activities in school

    Directory of Open Access Journals (Sweden)

    Ana Flávia Lopes Magela Gerhardt

    2010-06-01

    Full Text Available Este artigo reúne pressupostos teóricos da Linguística Cognitiva e da Psicolinguística, em especial os estudos em metacognição, a fim de discutir problemas relacionados à leitura nas aulas de língua materna e estrangeira, principalmente no que tange à validação das questões de interpretação de textos. Para tanto, analisamos questões presentes em materiais didáticos de língua materna e estrangeira, a fim de sugerir formas de trabalhar a interpretação de textos, a partir da visão de que a cognição humana opera em basicamente dois planos de percepção/conceptualização. Conscientes da necessidade de abordar em várias frentes o problema da má qualidade de leitura do aluno brasileiro, apresentamos nossa proposta como parte de um projeto de pesquisa maior, que inclui o que o aluno pode aprender acerca do funcionamento de sua própria mente, e como pode utilizá-la satisfatoriamente para realizar as atividades de leitura que lhe são solicitadas, na escola e fora dela.This paper assembles theoretical assumptions on Cognitive Linguistics and Psycholinguistics, especially those related to studies on Metacognition, in order to discuss problems on reading in native and foreign languages, mainly reading comprehension activities. We analyze activities of native and foreign language textbooks, in order to suggest interesting and relevant ways to work with reading comprehension, considering that human cognition basically operates in two levels of perception/conceptualization. Due to the need to address the problem of low quality of reading in Brazilian school in several ways, we present our proposal as a part of a greater research project, which includes how students can learn about their mind's work and how they can use it to accomplish reading activities in school and beyond.

  20. ANTIBACTERIAL ACTIVITY OF LENTINULA EDODES GROWN IN LIQUID MEDIUM Atividade antibacteriana de Lentinula edodes cultivado em meio líquido

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    Noemia Kazue Ishikawa

    2001-10-01

    Full Text Available The antibacterial activity of 35 isolates of Lentinula edodes, a shiitake mushroom, against Bacillus subtilis was evaluated by diffusion technique in agar with a semi-solid overlay. All isolates inhibited B. subtilis and the isolate Le1 promoted the formation of the largest inhibition zone. L. edodes Le1 also presented antibacterial activity against foodborne pathogens and food contaminant bacteria, particularly Gram-positive species. The antibacterial activity of the culture filtrate after 18-25 days of cultivation of L. edodes in broth at 25ºC was high. The inhibitory activity was observed only in the organic layer when the culture filtrate was partitioned between ethyl acetate and water, suggesting that the inhibitory substances have low polarity. The silica gel thin-layer zone at Rf values of 0.63-0.80, developed in chloroform - acetone - ethyl acetate - methanol = 40:5:5:2, was responsible for the antibacterial activity against B. subtilis. The inhibitory activity of L. edodes was detectable in the culture filtrate after heat treatment at 100ºC for 10 min and after storage at 4ºC for 120 days.A atividade antibacteriana de 35 isolados de Lentinula edodes (shiitake contra Bacillus subtilis foi avaliada pela técnica de difusão em sobrecamada de ágar semi-sólido. Todos os isolados avaliados inibiram o crescimento de B. subtilis sendo o isolado Le1 o que apresentou maior halo de inibição. L. edodes Le1 também inibiu o crescimento de bactérias patogênicas e deterioradoras de alimentos, especialmente as Gram-positivas. Maior atividade antibacteriana do filtrado da cultura de L. edodes em meio líquido foi observada entre 18-25 dias de incubação, a 25ºC. O fracionamento do filtrado da cultura com acetato de etila e água permitiu evidenciar a atividade antagonista somente na fase orgânica, sugerindo que as substâncias inibitórias apresentam baixa poloridade. A cromatografia em camada fina, com o sistema de solventes clorof

  1. Imobilização da pancreatina em carvão ativado e em alumina para o preparo de hidrolisados de soro de leite = Immobilization of pancreatin in activated carbon and in alumina for preparing whey hydrolysates

    Directory of Open Access Journals (Sweden)

    Viviane Dias Medeiros Silva

    2005-07-01

    Full Text Available Tendo como objetivo a redução de custos do processo de fabricação dehidrolisados protéicos, estudou-se neste trabalho a imobilização da pancreatina, por adsorção, em carvão ativado e em alumina. Para isso, foram testadas diferentes condições de imobilização (30, 60 e 90min a 25°C, e 12h a 5°C. Para verificar a taxa de imobilização, determinou-se indiretamente a enzima não adsorvida nos suportes. Ao se utilizar o carvão ativado, não foi observada diferença significativa entre as condições testadas, tendo-se obtido 100% de imobilização enzimática. Para a alumina, a melhor condição foi a de 90min, na qual se obteve 37% de imobilização. A medida do grau de exposição da fenilalanina, pela espectrofotometria derivada segunda, foi empregada para a determinação da estabilidade operacional da enzima, tendo sido mostrado que a imobilização em carvão ativado e emalumina permitiu a reutilização da pancreatina por até 5 vezes e 2 vezes, respectivamente.Immobilization of pancreatin in activated carbon and in alumina was studied for producing protein hydrolysates, in order to reduce the process costs. Different immobilization conditions were tested (30, 60 and 90min at 25°C, and 12h at 5°C. For estimating the immobilization rate the amount of the non-adsorbed enzyme on the supports was indirectly determined. When activated carbon was used, no significant difference was observed among the tested conditions, obtaining 100% of enzymatic immobilization. In case of alumina, the best condition showed to be the 90min treatment which produced 37% of immobilization. The evaluation of the degree of exposition ofphenylalanine, by second derivative spectrophotometry, was used for the determination of the enzyme operational stability, and showed that the immobilization in activated carbon and in alumina allowed the reusability of the pancreatin for 5 times and 2 times,respectively.

  2. Rapid shifts in <em>Atta cephalotesem> fungus-garden enzyme activity after a change in fungal substrate (Attini, Formicidae)

    DEFF Research Database (Denmark)

    Kooij, P W; Schiøtt, M; Boomsma, J J;

    2011-01-01

    the backbone structure of pectin molecules, relative to a pure diet of bramble leaves, and this happened predominantly in the most recently established top sections of fungus gardens. However, fungus-garden amylase activity did not significantly increase despite the substantial increase in starch availability......Fungus gardens of the basidiomycete Leucocoprinus gongylophorus sustain large colonies of leaf-cutting ants by degrading the plant material collected by the ants. Recent studies have shown that enzyme activity in these gardens is primarily targeted toward starch, proteins and the pectin matrix...... activity to provide a better match with substrate availability and that excess starch that is not protected by cell walls may be digested by the ants rather than by the fungus-garden symbiont. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00040-010-0127-9) contains...

  3. Correlation of the National Board of Medical Examiners Emergency Medicine Advanced Clinical Examination given in July to intern American Board of Emergency Medicine in-training examination scores, a predictor of performance?

    Directory of Open Access Journals (Sweden)

    Katherine Hiller

    2015-11-01

    Full Text Available Introduction: There is great variation in the knowledge base of Emergency Medicine (EM interns in July. The first objective knowledge assessment during residency does not occur until eight months later, in February, when the American Board of EM (ABEM administers the in-training examination (ITE. In 2013, the National Board of Medical Examiners (NBME released the EM Advanced Clinical Examination (EM-ACE, an assessment intended for fourth-year medical students. Administration of the EM-ACE to interns at the start of residency may provide an earlier opportunity to assess the new EM residents’ knowledge base. The primary objective of this study was to determine the correlation of the NBME EM-ACE, given early in residency, with the EM ITE. Secondary objectives included determination of the correlation of the United States Medical Licensing Examination (USMLE Step 1 or 2 scores with early intern EM-ACE and ITE scores and the effect, if any, of clinical EM experience on examination correlation. Methods: This was a multi-institutional, observational study. Entering EM interns at six residencies took the EM-ACE in July 2013 and the ABEM ITE in February 2014. We collected scores for the EMACE and ITE, age, gender, weeks of clinical EM experience in residency prior to the ITE, and USMLE Step 1 and 2 scores. Pearson’s correlation and linear regression were performed. Results: Sixty-two interns took the EM-ACE and the ITE. The Pearson’s correlation coefficient between the ITE and the EM-ACE was 0.62. R-squared was 0.5 (adjusted 0.4. The coefficient of determination was 0.41 (95% CI [0.3-0.8]. For every increase of one in the scaled EM-ACE score, we observed a 0.4% increase in the EM in-training score. In a linear regression model using all available variables (EM-ACE, gender, age, clinical exposure to EM, and USMLE Step 1 and Step 2 scores, only the EM-ACE score was significantly associated with the ITE (p<0.05. We observed significant colinearity

  4. Correlation of the National Board of Medical Examiners Emergency Medicine Advanced Clinical Examination Given in July to Intern American Board of Emergency Medicine in-training Examination Scores: A Predictor of Performance?

    Science.gov (United States)

    Hiller, Katherine; Franzen, Doug; Heitz, Corey; Emery, Matthew; Poznanski, Stacy

    2015-01-01

    Introduction There is great variation in the knowledge base of Emergency Medicine (EM) interns in July. The first objective knowledge assessment during residency does not occur until eight months later, in February, when the American Board of EM (ABEM) administers the in-training examination (ITE). In 2013, the National Board of Medical Examiners (NBME) released the EM Advanced Clinical Examination (EM-ACE), an assessment intended for fourth-year medical students. Administration of the EM-ACE to interns at the start of residency may provide an earlier opportunity to assess the new EM residents’ knowledge base. The primary objective of this study was to determine the correlation of the NBME EM-ACE, given early in residency, with the EM ITE. Secondary objectives included determination of the correlation of the United States Medical Licensing Examination (USMLE) Step 1 or 2 scores with early intern EM-ACE and ITE scores and the effect, if any, of clinical EM experience on examination correlation. Methods This was a multi-institutional, observational study. Entering EM interns at six residencies took the EM-ACE in July 2013 and the ABEM ITE in February 2014. We collected scores for the EM-ACE and ITE, age, gender, weeks of clinical EM experience in residency prior to the ITE, and USMLE Step 1 and 2 scores. Pearson’s correlation and linear regression were performed. Results Sixty-two interns took the EM-ACE and the ITE. The Pearson’s correlation coefficient between the ITE and the EM-ACE was 0.62. R-squared was 0.5 (adjusted 0.4). The coefficient of determination was 0.41 (95% CI [0.3–0.8]). For every increase of one in the scaled EM-ACE score, we observed a 0.4% increase in the EM in-training score. In a linear regression model using all available variables (EM-ACE, gender, age, clinical exposure to EM, and USMLE Step 1 and Step 2 scores), only the EM-ACE score was significantly associated with the ITE (pUSMLE scores. Gender, age and number of weeks of EM prior

  5. Structural and kinetic studies of the allosteric transition in <em>Sulfolobus solfataricusem> uracil phosphoribosyltransferase: Permanent activation by engineering of the C-terminus

    DEFF Research Database (Denmark)

    Christoffersen, Stig; Kadziola, Anders; Johansson, Eva

    2009-01-01

    Uracil phosphoribosyltransferase catalyzes the conversion of 5-phosphoribosyl- a-1-diphosphate (PRPP) and uracil to uridine monophosphate (UMP) and diphosphate (PPi). The tetrameric enzyme from Sulfolobus solfataricus has a unique type of allosteric regulation by cytidine triphosphate (CTP......) and guanosine triphosphate (GTP). Here we report two structures of the activated state in complex with GTP. One structure (refined at 2.8-Å resolution) contains PRPP in all active sites, while the other structure (refined at 2.9-Å resolution) has PRPP in two sites and the hydrolysis products, ribose-5-phosphate...

  6. Soil enzyme activities under long-term tillage and crop rotation systems in subtropical agro-ecosystems Atividade enzimática em solo sob plantio direto e rotações de culturas em agro-ecossistema subtropical

    Directory of Open Access Journals (Sweden)

    Elcio Liborio Balota

    2004-12-01

    Full Text Available Agricultural practices that reduce soil degradation and improve agricultural sustainability are needed particularly for tropical/subtropical soils. No-tillage planting causes minimal soil disturbance and combined with crop rotation may hold potential to meet these goals. Soil enzyme activities can provide information on how soil management is affecting the potential to perform the processes in soils such as decomposition and nutrient cycling. Soil enzyme activities were investigated in a split-plot experiment (3 replications where tillage (no till and conventional was the main plot and crop rotation (soybean/wheat, S/W; maize/wheat, M/W or cotton/wheat, C/W was the subplot. The experiment was established in 1976 in southern Brazil. Soil samples were taken at 0-5, 5-10 and 10-20 cm depths in 1997 and 1998. The 0-5 cm layer under NT system showed increases up 68% for amylase, 90% for cellulase, 219% for arylsulfatase, 46% for acid phosphatase, and 61% for alkaline phosphatase. There were significant correlations of soil enzyme activities with total organic C, and C and N microbial biomass. These results showed that NT increased microbial activity and that soil enzyme activity is a sensitive indicator of alteration soil quality by management.Práticas agrícolas que reduzam a degradação do solo e promovam sustentabilidade são importantes para os agrossistemas tropicais/subtropicais. O plantio direto (PD diminui as perdas de solo e, se combinado com rotação de culturas pode proteger o solo da degradação físico-química provocada pela agricultura intensiva. A atividade enzimática do solo pode fornecer importantes informações de como o manejo do solo está afetando a decomposição da material orgânica e a ciclagem dos nutrientes. Assim, avaliou-se a atividade das enzimas amilase, celulose, arilsulfatase, fosfatase ácida e fosfatase alcalina em um experimento a campo, instalado em 1976 em Londrina, PR, que tem como tratamentos o preparo

  7. Allosteric regulation of the GTP activated and CTP inhibited uracil phosphoribosyltransferase from the thermophilic archaeon <em>Sulfolobus solfataricusem>

    DEFF Research Database (Denmark)

    Jensen, Kaj Frank; Arent, Susan; Larsen, Sine;

    2005-01-01

    The upp gene, encoding uracil phosphoribosyltransferase (UPRTase) from the thermoacidophilic archaeon Sulfolobus solfataricus, was cloned and expressed in Escherichia coli. The enzyme was purified to homogeneity. It behaved as a tetramer in solution and showed optimal activity at pH 5.5 when...

  8. Atividade do sistema antioxidante e desenvolvimento de aerênquima em raízes de milho 'Saracura' Antioxidant system activity and aerenchyma formation in 'Saracura' maize roots

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    Fabricio José Pereira

    2010-05-01

    Full Text Available Este trabalho teve como objetivo avaliar a influência de sucessivos ciclos de seleção do milho 'Saracura' na atividade das enzimas do sistema antioxidante, e a relação dessas enzimas com a capacidade dessa variedade em desenvolver aerênquima. Sementes de 18 ciclos de seleção intercalados do milho 'Saracura' e da cultivar BR 107, sensível à hipoxia, foram semeadas em vasos e em casa de vegetação. As plantas foram submetidas ao alagamento intermitente de dois em dois dias. As amostras de raízes foram coletadas após 60 dias e analisaram-se as atividades das enzimas peroxidase do guaiacol, peroxidase do ascorbato e catalase, além da capacidade das plantas de cada ciclo desenvolverem aerênquima. Ao longo dos ciclos, as plantas apresentaram modificações na atividade das enzimas, com aumento na de peroxidase do ascorbato e diminuição na de catalase e de peroxidase do guaiacol. Observou-se, ainda, maior capacidade de desenvolver aerênquima nos últimos ciclos de seleção. A redução na atividade das enzimas do sistema antioxidante parece estar relacionada a um desbalanço na decomposição de H2O2.This work aimed to assess the influence of successive selection cycles in 'Saracura' maize on the enzyme activity of the antioxidant system and the relationship of these enzymes with the aerenchyma development capacity of this variety. Seeds of 18 intercalated selection cycles of the 'Saracura' maize and of the cultivar BR 107, sensitive to hipoxia, were sown in pots in the greenhouse. Plants were submitted to intermittent soil flooding each two days. After 60 days, the roots were sampled and analysis were done for the guaiacol peroxidase, ascorbate peroxidase, and catalase activities and for the capacity of the plants of each cycle to develop aerenchyma. The plants showed modifications in enzyme activity along the cycles, increasing the ascorbate peroxidase activity and decreasing the catalase and guaiacol peroxidase ones. A greater

  9. Low Apgar scores at 5 minutes in a low risk population: maternal and obstetrical factors and postnatal outcome Baixos índices de Apgar no quinto minuto de vida em população de baixo risco: fatores maternos e obstétricos e resultados pós-natais

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    Eugenia Maria Assunção Salustiano

    2012-10-01

    Full Text Available OBJECTIVE: To evaluate the association between Apgar scores of less than seven at five minutes (AS5min 7 at 5 minutes who were randomly selected by a computer program. The main outcomes were neonatal death, newborn respiratory distress, need for orotracheal intubation and neonatal intensive care unit (NICU, and hypoxic-ischemic-encephalopathy. RESULTS: After multiple regression analysis, repeated late decelerations on cardiotocography (OR: 2.4; 95% CI: 1.4-4.1 and prolonged second stage of labor (OR: 3.3; 95% CI: 1.3-8.3 were associated with AS5min 0.05. CONCLUSION: Repeated late decelerations and prolonged second stage of labor in the low-risk population are predictors of AS5min OBJETIVO: Avaliar a associação entre índice de Apgar menor que sete no 5º minuto, os fatores pré-natais e resultados pós-natais. MÉTODOS: Trata-se de estudo retrospectivo com 27.252 recém-nascidos em maternidade escola com população de baixo risco obstétrico, de janeiro de 2003 a dezembro de 2010. Prontuários de todos os casos com índice de Apgar 7 no 5º minuto, escolhidos ao acaso, foram revisados. Os principais desfechos estudados foram: óbito neonatal, insuficiência respiratória neonatal, necessidade de intubação orotraqueal e de unidade terapia intensiva (UTI neonatal e encefalopatia hipóxico-isquêmica. RESULTADOS: Após análise de regressão múltipla, desacelerações tardias (DIP II (OR: 2,4; IC95%: 1,4-4,1 e período expulsivo prolongado (OR: 3,3; IC 95%: 1,3-8,3 se associaram com Apgar < 7 no 5º minuto; assim como com insuficiência respiratória ao nascimento (OR: 3,0; IC 95%: 1,3-6,9, intubação traqueal (OR: 2,5; IC 95%: 1,2-4,8, necessidade de UTI neonatal (OR: 9,5; IC 95%: 6,7-16,8 e encefalopatia hipóxico-isquêmica (OR: 14,1; IC 95%: 3,6-54,7. Nenhuma outra variável prénatal se associou com Apgar < 7 no 5º minuto (p < 0,05. CONCLUSÃO: DIP II e período expulsivo prolongado estão associados com Apgar < 7 no 5º minuto em

  10. Prognóstico do duke-escore versus cintilografia em pacientes com fatores de risco para doença arterial coronariana: seguimento de um ano Prognosis of duke treadmill score versus scintilography in patients at risk for coronary artery disease: one year follow-up

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Gasperin

    2006-08-01

    Full Text Available OBJETIVO: Determinar a sensibilidade, a especificidade e o risco de eventos cardiovasculares em pacientes com Duke-escore (DE baixo, intermediário e alto risco, em comparação com a presença (ou não de defeitos de perfusão à cintilografia do miocárdio. MÉTODOS: Estudo prospectivo, consecutivo, com 173 pacientes com 2 ou mais fatores de risco para doença arterial coronariana (DAC, que foram submetidos à cintilografia de perfusão do miocárdio com tetrofosmin marcado com tecnécio-Tc 99m (CPM e ao teste ergométrico (aplicando-se o DE, de um bairro de Curitiba, entre janeiro de 2003 a fevereiro de 2004. Os pacientes tiveram seguimento de 13±1 meses e 162 completaram o acompanhamento. Foi avaliada a presença de morte, angina, infarto agudo do miocárdio, angioplastia coronariana e revascularização do miocárdio. RESULTADOS: A média do DE dos pacientes que apresentaram eventos (18 foi de -0,27 (95% IC= -3,97 a +3,91 e daqueles livres de eventos (144 foi de +4,92 (95% IC= +4,03 a +5,81, com pOBJECTIVE: The purpose was to determine the sensitivity, the specificity and a year-long risk of subsequent cardiovascular events in patients with low, intermediate and high risk prognostic Duke treadmill score (DTS in comparison with the presence (or not of the myocardial perfusion defects on radionuclide images. METHODS: A prospective study, with 173 consecutive patients with 02 or more risk factors to coronary artery disease (CAD, who underwent to exercise single photon - emission computed tomographic myocardial perfusion images using technetium-99m tetrophosmin (SPECT and treadmill test (with DTS, from one neighbourhood of Curitiba city, between January 2003 and February 2004, were followed up for cardiac-cause mortality and major cardiac events. Follow-up was performed in 13± 1 months and in 162 patients was complete. RESULTS: The DTS mean those patients with cardiac event (18 over a year was -0.27 (95% CI= -3.97 to +3.91 and those free

  11. Actividades enzimáticas antioxidativas em Cistus Ladanifer L. provenientes de áreas não contaminadas em elementos vestigiais Antioxidant enzymes activity of Cistus Ladanifer L. from areas non contaminated in trace elements

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    Erika Santos

    2011-07-01

    Full Text Available Avaliou-se a actividade das enzimas antioxidativas (catalase, peroxidase e superóxido dismutase e as concentrações em As, Cu, Pb e Zn nas folhas de duas populações de Cistus ladanifer L. colhidas, na Primavera e no Verão, em solos não contaminados em elementos vestigiais (Caldeirão e Pomarão e com condições climáticas diferentes. Nos solos das duas áreas, as concentrações totais e disponíveis (extracção com DTPA em elementos vestigiais foram baixas. A distribuição dos elementos pelas folhas novas e maduras foi semelhante entre áreas e estações do ano. As actividades enzimáticas variaram consoante a população. As folhas colhidas nas duas estações do ano, excepto as folhas novas de Verão do Pomarão, apresentaram actividade enzimática na fracção solúvel e iónica. Comparando as estações do ano e áreas de amostragem, constatou-se que as actividades enzimáticas representam um mecanismo de tolerância a vários factores de stresse (radiação UV, temperatura do ar elevada no verão, défice hídrico no verão, baixa-média fertilidade do solo e conteúdo de elementos vestigiais no solo, o que confere uma elevada plasticidade à espécie.The aim of this study was to evaluate the antioxidant enzymes activity (catalase, peroxidase and superoxide dismutase and the concentrations of As, Cu, Pb and Zn in leaves from two populations of Cistus ladanifer growing on soils non-contaminated with trace elements (Caldeirco and Pomarco, but with different climatic conditions and in two different seasons (spring and summer. In both areas, total and available concentrations (DTPA extraction of trace elements in soils were low. The distribution of elements for young and mature leaves was similar between areas and seasons. The enzyme activities varied with the plant population. Leaves collected in the two seasons, except young leaves from Pomarco collected in summer, showed enzymatic activity in the soluble and ionic fractions

  12. Evaluation of the antibacterial activity of Chilean plants traditionally used for wound healing therapy against multidrug-resistant <em>Staphylococcus aureusem>

    DEFF Research Database (Denmark)

    Holler, Jes Gitz; Søndergaard, Karen; Slotved, Hans-Christian

    2012-01-01

    Anti-staphylococcal activity of Chilean medicinal plants traditionally used by the Huilliche people for wound healing therapy was evaluated against nine STAPHYLOCOCCUS AUREUS strains. Three extracts of 26 plant samples (20 species) were evaluated by agar overlay bioautography and MIC determination...... of Huilliche medicinal plants and the hypothesis that these plants are promising sources of potential anti-staphylococcal agents towards multidrug-resistant strains....

  13. Us'em: the user-centered design of a device for motivating stroke patients to use their impaired arm-hand in daily life activities.

    Science.gov (United States)

    Markopoulos, Panos; Timmermans, Annick A A; Beursgens, Luuk; van Donselaar, Rik; Seelen, Henk A M

    2011-01-01

    Stroke leaves the majority of its survivors with an impairment of the upper extremity that affects their ability to live independently and their quality of life. Rehabilitation research shows that practice of everyday life activities in a natural context may sustain or even improve arm-hand performance, even during chronic stages after stroke. Based on this insight we designed, developed and evaluated Us'em; this consists of two watch-like accelerometry devices that provide feedback to stroke patients regarding the usage of their impaired versus their non-affected upper extremity. System usability and treatment credibility/expectancy were evaluated positively by therapists and patients.

  14. Human platelet nitric oxide synthase activity: an optimized method Atividade da óxido nítrico sintase em plaquetas humanas: um método otimizado

    Directory of Open Access Journals (Sweden)

    Elisa Mitiko Kawamato

    2002-09-01

    Full Text Available We investigated the kinetic analysis of human platelet Nitric Oxide Synthase (NOS activity by the rate of conversion of [³H] arginine to [³H]-citrulline in unstimulated fresh platelets. NOS activity was present in the membrane fraction and cytosol, and was Ca2+- and calmodulin dependent which is a characteristic of endothelial NOS. NOS activity was also dependent of NADPH since the omission of this cofactor induced an important decrease (85,2% in the enzyme activity. The kinetic varied with protein and arginine concentration but optimum concentrations were found up to 60 minutes, and up to 80 µg of protein at 120 nM of arginine and 0.5 µCi of ³H-arginine. NOS activity in the absence of FAD (flavin adenine dinucleotide, FMN (flavin mononucleotide and BH4 (tetrahydrobiopterin was only 2.8% of the activity measured in the presence of these three cofactors. The enzyme activity was completely inhibited by L-NAME (1 mM (98.1 % and EGTA (5 mM (98.8 %. Trifluoperazine (TFP caused 73.2% inhibition of the enzyme activity at 200 µM and 83.8 % at 500 µM. Under basal conditions, NOS Km for L-arginine was 0.84 ± 0.08 µM and mean Vmax values were 0.122 ± 0.025 pmol.mg-1.min-1. Mean human NOS platelet activity was 0.020 ± 0.010 pmol.mg-1.min-1. Results indicate that the eNOS in human platelet can be evaluated by conversion of [³H]-arginine to [³H]citrulline in an optimized method, which provide reproducible and accurate results with good sensitivity to clinical experiments involving neurological and psychiatric diseases.A análise cinética da atividade da óxido nítrico sintase (NOS plaquetária foi avaliada pela conversão de [³H]-arginina em [³H]-citrulina em plaquetas humanas frescas não estimuladas. A atividade da NOS foi detectada na fração citosólica e na membrana, além de ser dependente de Ca2+-calmodulina, que é uma característica da NOS endotelial (eNOS. A omissão de NADPH levou à diminuição da atividade da NOS dependente da

  15. 5种ANCA相关性血管炎活动性评分量表的比较%Comparison of Five Different Disease Activity Scoring Scales for ANCA-associated Vasculitis

    Institute of Scientific and Technical Information of China (English)

    张立民; 吴庆军; 冯胜; 曾小峰

    2010-01-01

    目的 比较5种系统性血管炎活动性评分量表的可靠性及相关性,以指导临床应用.方法 以45例抗中性粒细胞胞浆抗体(anti-neutrophil cytoplasmic autoantibody,ANCA)相关性血管炎(ANCA-associated vasculitis,AAV)患者为研究对象,其中包括韦格纳肉芽肿(wegener's granulomatosis,WG)患者30例和显微镜下多血管炎(microscopic polyangitis,MPA)患者15例.由2名评测者分别根据下述5种目前国际上常用的活动指数评价量表进行计分:伯明翰血管炎活动性评分(the Birmingham Vasculitis Activity Score,BVAS1994),韦格纳肉芽肿专用的BVAS(the BVAS for Wegener granulomatosis,BVAS/WG) ,BVAS2003,疾病累及范围指数(the Disease Extent Index,DEI),5因子评分(the Five Factor Score,FFS).结果 5种评分量表均有很高的重复信度(ICC 0.97~0.98)和评测者间信度(ICC 0.93~0.98).BVAS1994与BVAS2003(rs=0.961)、BVAS/WG(rs =0.872)、及DEI(rs=0.818),BVAS2003与BVAS/WG(rs=0.872)、DEI(rs=0.826),BVAS/WG与DEI(rs=0.776)间有较高的相关性,P值均小于0.001.FFS与其他评分量表之间无相关性.结论 目前AAV活动性评分量表是可靠、有效的.应用不同评分量表所得数据之间可以相互比较.

  16. Skin scoring in systemic sclerosis

    DEFF Research Database (Denmark)

    Zachariae, Hugh; Bjerring, Peter; Halkier-Sørensen, Lars

    1994-01-01

    Forty-one patients with systemic sclerosis were investigated with a new and simple skin score method measuring the degree of thickening and pliability in seven regions together with area involvement in each region. The highest values were, as expected, found in diffuse cutaneous systemic sclerosis...... (type III SS) and the lowest in limited cutaneous systemic sclerosis (type I SS) with no lesions extending above wrists and ancles. A positive correlation was found to the aminoterminal propeptide of type III procollagen, a serological marker for synthesis of type III collagen. The skin score...

  17. Prevalence and correlates of physical activity among adolescents from Southern Brazil Prevalencia de actividad física en adolescentes y factores asociados Prevalência de atividade física em adolescentes e fatores associados

    Directory of Open Access Journals (Sweden)

    Samuel C Dumith

    2010-06-01

    Full Text Available OBJECTIVE: To estimate the prevalence and identify correlates of physical activity among adolescents. METHODS: Cross-sectional study nested within a cohort of 4,325 subjects from the city of Pelotas, Southern Brazil, aged 14-15 years in 2008. Physical activity was analyzed using three different approaches: (1 prevalence of any leisure-time physical activity; (2 prevalence of any active commuting to school; and (3 prevalence of engaging in at least 300 minutes per week of both (1 and (2 combined. Independent variables included sociodemographic, behavioral, social, and biological characteristics, and number of different leisure-time physical activites practiced. Statistical analyses were carried out using Poisson regression. RESULTS: The proportion of adolescents involved in any type of leisure-time physical activity was 75.6%, while 73.4% displayed some form of active commuting to school. Prevalence of total physical activity score (> 300 min/week was 48.2%, being greater among boys (62.6% than among girls (34.5%. Furthermore, prevalence increased along with the number of physical activity modalities practiced (pOBJETIVO: Estimar la prevalencia de actividad física entre adolescentes y identificar los factores asociados. MÉTODOS: Estudio transversal anidado en una cohorte con 4.325 individuos de 14-15 años en Pelota, Sur de Brasil, en 2008. La actividad física fue analizada por medio de tres diferentes abordajes: 1 prevalencia de alguna actividad física de ocio; 2 prevalencia de algún traslado activo para la escuela; 3 prevalencia de compromiso de por lo menos 300 minutos por semana en la combinación de ambos (1 y 2. Variables independientes incluyeron características demográficas, socioeconómicas, comportamentales, sociales y biológicas y número de actividades físicas practicadas en el tiempo de ocio. Los análisis estadísticos fueron hechos por la regresión de Poisson. RESULTADOS: La proporción de adolescentes envueltos en alguna

  18. Serotonin transporter protein (SERT) and P-glycoprotein (P-gp) binding activity of montanine and coccinine from three species of <em>Haemanthus> L. (Amaryllidaceae)

    DEFF Research Database (Denmark)

    Stafford, Gary Ivan; Birer, C.; Brodin, Birger;

    2013-01-01

    % montanine. The three extracts and two isolated alkaloids were evaluated for binding to the serotonin transporter protein (SERT) in vitro. Affinity to SERT was highest in H. coccineus (IC50 = 2.0 ± 1.1 μg/ml) followed by H. montanus (IC50 = 6.8 ± 1.0 μg/ml) and H. sanguineus (IC50 = 28.7 ± 1.1 μg....../ml). Montanine (IC50 = 121.3 ± 3.6 μM or 36.56 ± 1.14 μg/ml; Ki = 66.01 μM) was more active than coccinine (IC50 = 196.3 ± 3.8 μM or 59.15 ± 1.08 μg/ml; Ki = 106.8 μM), both of which were less active than the total alkaloid extracts of each species investigated. The possible synergistic effects of two coccinine...

  19. Development of the Crohn's disease digestive damage score, the Lémann score

    DEFF Research Database (Denmark)

    Pariente, Benjamin; Cosnes, Jacques; Danese, Silvio

    2011-01-01

    Crohn's disease (CD) is a chronic progressive destructive disease. Currently available instruments measure disease activity at a specific point in time. An instrument to measure cumulative structural damage to the bowel, which may predict long-term disability, is needed. The aim of this article...... is to outline the methods to develop an instrument that can measure cumulative bowel damage. The project is being conducted by the International Program to develop New Indexes in Crohn's disease (IPNIC) group. This instrument, called the Crohn's Disease Digestive Damage Score (the Lémann score), should take...

  20. Impactos Ambientais das Atividades Agrícolas em Roraima. = Environmental Impacts of Agriculture Activity in Roraima State.

    Directory of Open Access Journals (Sweden)

    Valdinar Ferreira Melo

    2008-07-01

    Full Text Available A agricultura foi a grande responsável pelo processo de colonização do Brasil. No entanto, estas atividades se desenvolveram ás expensas de ações negativamente impactantes ao meio ambiente. Este trabalho tem com objetivo abordar os impactos ambientais causados pela atividade agrícola no estado de Roraima, despertando o interesse da comunidade para o uso de uma agricultura fundamentada no conceito de sustentabilidade. A prática agropecuária no Brasil, inicialmente de forma empírica, sem muito conhecimento e preocupação com seus efeitos no ambiente, causou a dizimação de grande parte das florestas e a biodiversidade, mas, também, possibilitou a ocupação da terra e a definição dos limites territoriais brasileiros, definindo-se como de grande importância para a sustentação da economia, imprimindo ao Brasil sua vocação agrícola. A atividade nos anos 60 foi concebida para a validação de pacotes tecnológicos importados, contribuiu para a execução de práticas socialmente excludentes e ambientalmente danosas, com reflexos positivos na produção agrícola e comércio de insumos, à custa da implantação de sistemas monoculturais, com motomecanização, irrigação e emprego intensivo de fertilizantes químicos e pesticidas. A impropriedade ambiental deste modelo originou movimentos que culminaram com a conscientização para estas questões, tendo como respostas a elaboração de instrumentos técnicos e jurídicos, e formulação de propostas para avaliar e mitigar os impactos ambientais e modificar as ações humanas, tornando-as mais condizentes com novos paradigmas da sociedade. Em Roraima, esta atividade sofre uma nova mudança, onde as técnicas primitivas de exploração agrícola começam a ser substituídas por atividades tecnificadas com o uso intensivo de tecnologias, com risco de improbidade ambiental que pode culminar com a degradação do meio, caso não haja uma perícia profunda das caracter

  1. Estimating Decision Indices Based on Composite Scores

    Science.gov (United States)

    Knupp, Tawnya Lee

    2009-01-01

    The purpose of this study was to develop an IRT model that would enable the estimation of decision indices based on composite scores. The composite scores, defined as a combination of unidimensional test scores, were either a total raw score or an average scale score. Additionally, estimation methods for the normal and compound multinomial models…

  2. Formamido-Diterpenes from the South China Sea Sponge <em>Acanthella cavernosaem>

    Directory of Open Access Journals (Sweden)

    Bao-Hua Zhang

    2012-07-01

    Full Text Available Seven new formamido-diterpenes, cavernenes A–D (14, kalihinenes E and F (56, and kalihipyran C (7, together with five known compounds (812, were isolated from the South China Sea sponge <em>Acanthella cavernosaem>. Structures were established using IR, HRESIMS, 1D and 2D NMR, and single X-ray diffraction techniques. The isolated compounds were assessed for their cytotoxicity against a small panel of human cancer cell lines (HCT-116, A549, HeLa, QGY-7701, and MDA-MB-231 with IC50 values in the range of 6–18 μM. In addition, compound 9 showed weak antifungal activity against <em>Trichophyton rubrumem> and <em>Microsporum gypseumem> with MIC values of 8 and 32 μg/mL, respectively, compound 10 displayed weak antifungal activity against fungi <em>Candida albicansem>, <em>C>ryptococcus neoformansem>, <em>T. rubrumem>, and<em> M. gypseum em>with MIC values of 8, 8, 4, and 8 μg/mL, respectively.

  3. Conclusion on the peer review of the pesticide risk assessment of the active substance <em>Pseudomonas sp.em> strain DSMZ 13134

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2012-12-01

    Full Text Available The conclusions of the European Food Safety Authority (EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State the Netherlands, for the pesticide active substance Pseudomonas sp. strain DSMZ 13134 are reported. The context of the peer review was that required by Commission Regulation (EU No 188/2011. The conclusions were reached on the basis of the evaluation of the representative uses of Pseudomonas sp. strain DSMZ 13134 as a fungicide on seed potatoes, flowers, tomatoes, cucumbers, peppers, eggplant, lettuce and cabbage. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.

  4. 3 D localization system for inspection activities in metallic plates; Sistema de localizacao em tres dimensoes para auxilio na atividade de inspecao em chapas metalicas

    Energy Technology Data Exchange (ETDEWEB)

    Bonacin, Mario Vicente; Polli, Helton Luis; Czaikowski, Daniel Irineu; Arruda, Lucia Valeria Ramos de; Neves Junior, Flavio; Oliveira, Daniel Rossato de [Universidade Tecnologica Federal do Parana (UTFPR), Curitiba, Parana (Brazil)

    2008-07-01

    This work presents the development of a 3D localization system based on inertial sensors. The prototype aims for its application in the oil and gas industry, which presents deficiencies on automation of inspection procedures. Recent advances on the field of Nondestructive Testing (NDT) have contributed to automation of these inspections, but installation and removal of NDT equipment, as well as location measurements and data acquired processing, are still highly dependent on labour-human. However, only the double integration of data from the inertial sensors - position determination - does not reach the precision level required by inspection activity. It requires the use of techniques and methods to minimize errors. Different models and techniques can be applied to minimize these undesired effects in addition with filters as the Kalman filter, widely used on problems of estimation of trajectories and fusion of sensors. This paper presents the modeling and implementation of some of these techniques, obtaining interesting results. (author)

  5. Production of barley endoprotease B2 in <em>Pichia pastorisem> and its proteolytic activity against native and recombinant hordeins

    DEFF Research Database (Denmark)

    Rosenkilde, Anne Lind; Dionisio, Giuseppe; Holm, Preben Bach

    2014-01-01

    Barley (Hordeum vulgare L.) cysteine proteases are of fundamental biological importance during germination but may also have a large potential as commercial enzyme. Barley cysteine endoprotease B2 (HvEPB2) was expressed in Pichia pastoris from a pPICZαA based construct encoding a HvEPB2 C......-terminal truncated version (HvEPB2ΔC) and a proteolytic resistant His6 tag. Maximum yield was obtained after 4 days of induction. Recombinant HvEPB2ΔC (r-HvEPB2ΔC) was purified using a single step of Ni2+-affinity chromatography. Purified protein was evaluated by SDS–PAGE, Western blotting and activity assays...

  6. Multiple heat priming enhances thermo-tolerance to a later high temperature stress <em>via em>improving subcellular antioxidant activities in wheat seedlings

    DEFF Research Database (Denmark)

    Wang, Xiao; Cai, Jian; Liu, Fulai

    2014-01-01

    Seedlings of winter wheat (Triticum aestivum L.) were firstly twice heat-primed at 32/24 °C, and subsequently subjected to a more severe high temperature stress at 35/27 °C. The later high temperature stress significantly decreased plant biomass and leaf total soluble sugars concentration. However...... an improvement of light use efficiency due to the priming pre-treatment. Under the later high temperature stress, PH could be maintained a better redox homeostasis than NH, as exemplified by the higher activities of superoxide dismutase (SOD) in chloroplasts and glutathione reductase (GR), and of peroxidase (POD......, heat priming effectively improved thermo-tolerance of wheat seedlings subjected to a later high temperature stress, which could be largely ascribed to the enhanced anti-oxidation at the subcellular level....

  7. Developing Scoring Algorithms (Earlier Methods)

    Science.gov (United States)

    We developed scoring procedures to convert screener responses to estimates of individual dietary intake for fruits and vegetables, dairy, added sugars, whole grains, fiber, and calcium using the What We Eat in America 24-hour dietary recall data from the 2003-2006 NHANES.

  8. Avaliação da extensão da neoplasia em câncer da próstata: valor do PSA, da percentagem de fragmentos positivos e da escala de Gleason Extraprostatic disease prediction in patients with carcinoma of the prostate: role of PSA, prostatic biopsy fragments percentage and Gleason score

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Calvete

    2003-09-01

    Full Text Available OBJETIVOS: Avaliar o comportamento da percentagem de fragmentos da biópsia prostática, guiada por ultra-sonografia transretal, na previsão de doença extraprostática em pacientes com adenocarcinoma localizado de próstata e, também, comparar a eficiência deste parâmetro com aqueles obtidos pela avaliação do PSA sérico e escala de Gleason pré-operatórios. MÉTODOS: Foi realizado estudo retrospectivo não controlado de 522 pacientes portadores de adenocarcinoma localizado de próstata e submetidos a tratamento cirúrgico através da prostatectomia radical retropúbica. A idade dos pacientes variou entre 42 a 76 anos, média de 62,44 anos. Todos os pacientes foram submetidos à ultra-sonografia transretal com biópsia prostática (direta da lesão e/ou área suspeita e sextante antes da prostatectomia radical retropúbica. Os 522 pacientes foram divididos em grupos quanto à percentagem de fragmentos positivos encontrados na biópsia, que foram correlacionados com os achados anatomopatológicos de doença intraprostática (confinada à glândula e extraprostática (invasão tumoral da gordura periprostática e/ou invasão de colo vesical e/ou invasão das vesículas seminais e/ou linfonodos pélvicos positivos, do espécime cirúrgico. RESULTADOS: Na análise da percentagem de fragmentos positivos os grupos G1(0-25%, G2(26-50% e G3(51-75% apresentaram incidência de doença intraprostática duas a três vezes maior do que extraprostática. No entanto, quando mais de 75% dos fragmentos de biópsia foram positivos (G4 76-100%, a relação se inverteu, ocorrendo uma predominância de doença extraprostática sobre a doença intraprostática. Neste grupo 56,98% dos pacientes evidenciaram doença extraprostática. Houve diferença, estatisticamente, significativa da doença extraprostática entre os grupos G3 e G4 (p = 0,0068. CONCLUSÕES: Quando comparamos os três parâmetros para avaliar a ordem de eficiência em prever doença extraprost

  9. Measurement of plasma levels of vascular endothelial growth factor in prostate cancer patients: relationship with clinical stage, Gleason score, prostate volume, and serum prostate-specific antigen Medida da concentração plasmática do fator de crescimento do endotélio vascular em pacientes com câncer prostático: relação com estado clinico, gleason score, volume prostático e PSA sérico

    Directory of Open Access Journals (Sweden)

    José Luis Ferreira Duque

    2006-10-01

    Full Text Available PURPOSE: This study focused on circulating levels of vascular endothelial growth factor in patients with prostate cancer compared to a normal population. METHODS: We analyzed 26 normal individuals and 80 patients with prostate cancer. Blood was drawn from all subjects, and plasma was extracted to determine the concentration of vascular endothelial growth factor using a quantitative immunoassay technique (ELISA-enzyme-linked immunosorbent assay. RESULTS: The median plasma level of vascular endothelial growth factor was significantly elevated in patients with metastatic disease compared to patients with localized disease and with healthy controls. Patients with serum prostate-specific antigen > 20 ng/mL had significantly higher levels of plasma vascular endothelial growth factor than patients with serum prostate-specific antigen OBJETIVO: Analisar os níveis circulantes do fator de crescimento do endotélio vascular em pacientes com câncer prostático comparados com uma população de indivíduos eutróficos. MÉTODOS: Vinte e seis indivíduos eutróficos e oitenta pacientes com câncer de próstata foram analisados nesse estudo. A coleta sangüínea foi realizada da mesma maneira em todos os pacientes e o plasma foi extraído para a determinação dos níveis do fator de crescimento do endotélio vascular, utilizando-se o método quantitativo ELISA (enzyme-linked immunosorbent assay. RESULTADOS: Os níveis de fator de crescimento do endotélio vascular plasmático encontraram-se significativamente elevados nos pacientes com doença metastática quando comparados com pacientes com doença localizada e com indivíduos sadios. Pacientes com PSA sérico maior que 20 ng/ml apresentaram níveis maiores de fator de crescimento do endotélio vascular plasmático quando comparados com pacientes com PSA menor que 20 ng/ml. Houve uma tendência dos pacientes com escore de Gleason de 8 a 10 apresentarem níveis maiores do fator de crescimento do endot

  10. Nitrogen nutrition of <em>Canna indicaem>: Effects of ammonium versus nitrate on growth, biomass allocation, photosynthesis, nitrate reductase activity and N uptake rates

    DEFF Research Database (Denmark)

    Konnerup, Dennis; Brix, Hans

    2010-01-01

    and plant morphology of C. indica were indifferent to N nutrition. However, NH4+ fed plants had higher concentrations of N in the tissues, lower concentrations of mineral cations and higher contents of chlorophylls in the leaves compared to NO3- fed plants suggesting a slight advantage of NH4+ nutrition...... and was induced by NO3- in the culture solutions corresponding to the pattern seen in fast growing terrestrial species. Plants fed with only NO3- had high NRA (22 and 8 μmol NO2- g-1 DW h-1 in leaves and roots, respectively) whereas NRA in NH4+ fed plants was close to zero. Plants supplied with both forms of N......The effects of inorganic nitrogen (N) source (NH4+, NO3- or both) on growth, biomass allocation, photosynthesis, N uptake rate, nitrate reductase activity and mineral composition of Canna indica were studied in hydroponic culture. The relative growth rates (0.05-0.06 g g-1 d-1), biomass allocation...

  11. Conclusion on the peer review of the pesticide risk assessment of the active substances <em>Beauveria bassianaem> strains ATCC-74040 and GHA

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2013-01-01

    Full Text Available The conclusions of the European Food Safety Authority (EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State Germany, for the pesticide active substances Beauveria bassiana strains ATCC-74040 and GHA are reported. The context of the peer review was that required by Commission Regulation (EC No 2229/2004, as amended by Commission Regulation (EC No 1095/2007 and Commission Regulation (EU No 114/2010. The conclusions were reached on the basis of the evaluation of the representative uses of Beauveria bassiana strains ATCC-74040 and GHA as an insecticide on tomatoes for strain ATCC-74040 and on tomatoes, cucumbers and ornamentals for strain GHA. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.

  12. Physical activity and depressive symptoms in community-dwelling elders from southern Brazil Atividade física e sintomas depressivos em idosos sul-brasileiros da comunidade

    Directory of Open Access Journals (Sweden)

    César L. Reichert

    2011-06-01

    Full Text Available OBJECTIVE: To determine the existence of a relationship between physical activity and depressive symptoms in community-dwelling elders. METHOD: This is a cross-sectional, population-based study, which included 379 community-dwelling elders from Novo Hamburgo, state of RS, Brazil. The level of physical activity was estimated using the International Physical Activity Questionnaire and depressive symptoms were diagnosed according to the Yesavage Geriatric Depression Scale. The association between the level of physical activity and depressive symptoms was analyzed by logistic regression. RESULTS: A tendency towards a lower prevalence of depressive symptoms was observed in individuals with higher levels of physical activity, both in the sample as a whole as well as among men, but not among women (p for linear trend 0.04, 0.03 and 0.36, respectively. The odds ratio of the presence of depressive symptoms in the very active group as compared against that of the insufficiently active group was 0.32 (95% CI: 0.12-0.86 for men and 0.76 (95% CI: 0.39-1.46 for women. CONCLUSION: In this population of aged individuals, more intense physical activity is related to a lower prevalence of depressive symptoms. As shown by gender stratification, physical activity is inversely related to depressive symptoms in men, albeit not in women.OBJETIVO: Avaliar a relação entre atividade física e sintomas depressivos em idosos da comunidade. MÉTODO: Estudo transversal de base populacional que incluiu 379 idosos da comunidade da cidade de Novo Hamburgo-RS, Brasil. O nível de atividade física foi estimado pelo Questionário Internacional de Atividade Física e os sintomas depressivos foram diagnosticados por meio da Escala de Depressão Geriátrica de Yesavage. A associação entre nível de atividade física e sintomas depressivos foi analisada por regressão logística. RESULTADOS: Foi observada uma tendência a menor prevalência de sintomas depressivos em indiv

  13. Physical activity and depressive symptoms in community-dwelling elders from southern Brazil Atividade física e sintomas depressivos em idosos sul-brasileiros da comunidade

    Directory of Open Access Journals (Sweden)

    César L. Reichert

    2011-01-01

    Full Text Available OBJECTIVE: To determine the existence of a relationship between physical activity and depressive symptoms in community-dwelling elders. METHOD: This is a cross-sectional, population-based study, which included 379 community-dwelling elders from Novo Hamburgo, state of RS, Brazil. The level of physical activity was estimated using the International Physical Activity Questionnaire and depressive symptoms were diagnosed according to the Yesavage Geriatric Depression Scale. The association between the level of physical activity and depressive symptoms was analyzed by logistic regression. RESULTS: A tendency towards a lower prevalence of depressive symptoms was observed in individuals with higher levels of physical activity, both in the sample as a whole as well as among men, but not among women (p for linear trend 0.04, 0.03 and 0.36, respectively. The odds ratio of the presence of depressive symptoms in the very active group, as compared against that of the insufficiently active group was 0.32 (95% CI: 0.12-0.86 for men and 0.76 (95% CI: 0.39-1.46 for women. CONCLUSION: In this population of aged individuals, more intense physical activity is related to a lower prevalence of depressive symptoms. As shown by gender stratification, physical activity is inversely related to depressive symptoms in men, albeit not in women.OBJETIVO: Avaliar a relação entre atividade física e sintomas depressivos em idosos da comunidade. MÉTODO: Estudo transversal de base populacional que incluiu 379 idosos da comunidade da cidade de Novo Hamburgo-RS, Brasil. O nível de atividade física foi estimado pelo Questionário Internacional de Atividade Física e os sintomas depressivos foram diagnosticados por meio da Escala de Depressão Geriátrica de Yesavage. A associação entre nível de atividade física e sintomas depressivos foi analisada por regressão logística. RESULTADOS: Foi observada uma tendência a menor prevalência de sintomas depressivos em indiv

  14. Dosagem sérica de adenosina deaminase em lúpus eritematoso sistêmico: ausência de associação com atividade de doença Levels of serum adenosine deaminase in systemic lupus erythematosus: lack of association with disease activity

    Directory of Open Access Journals (Sweden)

    Isabella Lima

    2005-10-01

    Full Text Available O lúpus eritematoso sistêmico (LES é uma doença inflamatória auto-imune, que evolui intercalando períodos de atividade e remissão. OBJETIVO: avaliar a associação da dosagem sérica de adenosina deaminase (ADA e atividade do LES, segundo os critérios do SLEDAI 2K - Systemic lupus erythematosus disease activity index. MÉTODOS: avaliou-se 82 pacientes com LES atendidos em um hospital de referência para o tratamento do LES em Salvador, BA, Brasil. A atividade de doença foi determinada pelo SLEDAI 2K e a dosagem sérica da ADA realizada por colorimetria. RESULTADOS: oitenta e uma pacientes (98,78% eram do sexo feminino e a idade média foi de 35,07±11,73 anos. O escore de SLEDAI médio foi de 11,66±5,89; a média de ADA sérica foi de 38,24±13,61U/l; C3 de 91,93±27,39 mg/dl; C4 de 15,17±5,77 mg/dl e a pesquisa de anticorpos anti-DNA nativo (aDNAn foi positiva em 31 casos (37,8%. Não houve correlação entre os níveis séricos de ADA e escore do SLEDAI. A ADA sérica correlacionou-se inversamente com C4 (r=-0,336 e p=0,001. CONCLUSÕES: no presente estudo a dosagem sérica de ADA não se associou a atividade de doença segundo os critérios do SLEDAI 2K, sugerindo que esse teste não deve ser utilizado como marcador de atividade de doença em LES. Esse resultado diverge da maioria dos trabalhos publicados, o que pode ser explicado pela dificuldade de padronização da técnica de dosagem da ADA ou por diferença nas diversas populações estudadas.Systemic lupus erythematosus (SLE is an autoimmune inflammatory disease, with a variable course and characterized by periods of remissions and exacerbations. OBJECTIVE: To evaluate the association between serum adenosine deaminase (ADA levels and disease activity in SLE. METHODS: Eighty two SLE patients seen at Santa Izabel Hospital in Salvador, BA, Brazil, were studied. Disease activity was measured by SLEDAI 2K- Systemic Lupus Erythematosus Disease Activity Index, and serum ADA was

  15. Rules activation system in real time (SARTRE): a contribution to operational quality; Sistema de ativacao de regras em tempo real (SARTRE): uma contribuicao para a qualidade operativa

    Energy Technology Data Exchange (ETDEWEB)

    Soares, Paulo David Campos; Torino, Celso Villar; Gimenez Isasi, Ramon Antonio; Davalos Martinez, Luis Concepcion; Soto Santacruz, Heriberto [Itaipu Binacional, Foz do Iguacu, PR (Brazil)]. E-mail: david@fnn.net

    2000-07-01

    This paper is a technical proposal for the real time activation of hydroelectric power plant operational rules, from acquired events of a SCADA/EMS digital system. Messages will be automatically activated whenever the acquired data, added to each implanted rule logical structure, identify any violation whatsoever of the in force instruction. Those messages will contain, in a standard way, information on the violation identified by the system, the address of the instruction generating the rule, and the action that will be taken by operator for regularization of the situation. This paper presents the three types of rules identified in the Itaipu power plant operation instructions, examples of the rules application, and also the type of available technical and management reports allowing training actions, improvement of instructions writing, identification of conflicting norm restrictions, and requests of priority actions from the maintenance area.

  16. Phenolic compounds, carotenoids and antioxidant activity in plant products / Compostos fenólicos, carotenóides e atividade antioxidante em produtos vegetais

    Directory of Open Access Journals (Sweden)

    Maria Gabriela Bello Koblitz

    2010-09-01

    Full Text Available The respiratory process and several aerobic cells oxidative reactions lead to the formation of free radicals which contribute to the appearance of different diseases. The human cells depend on their antioxidant ability to provide protection against the prejudicial effects of free radical and reactive oxygen species that are inevitable consequences of aerobic life. Several epidemiologic studies indicate that high plant products ingestion is associated to a reduction in the hazard of a variety of cronical diseases such as arteriosclerosis and cancer. These effects have been specifically attributed to the plant compounds that have antioxidant activity: vitamin C and E, phenolic compounds, specially flavonoids, and carotenoids. Phenolic compounds act as antioxidants, not only for their ability to donate hydrogen atoms or electrons, but also because of their stable intermediary radicals, that prevent the oxidation of many food ingredients, especially lipids. Carotenoids are built by polyene chains in a long conjugated double bonds system, electron rich, which is responsible for the antioxidant activity of these compounds, by the absorption of singlet oxygen and free radicals, to interrupt the chain reaction they are involved in. This paper had as a goal to review the different qualitative and quantitative evaluation methods of the main non-nutrient antioxidants in plant originated foods: phenolic compounds and carotenoids.O processo respiratório e diversas reações oxidativas das células aeróbicas levam à formação de radicais livres, que contribuem para o aparecimento de diversas doenças. As células humanas dependem de sua capacidade antioxidante para fornecer proteção contra os efeitos prejudiciais de radicais livres e espécies reativas do oxigênio, que são conseqüências inevitáveis da vida aeróbica. Vários estudos epidemiológicos indicam que a alta ingestão de produtos vegetais está associada com uma redução no risco de uma

  17. Atividade antimicrobiana in vitro de produtos vegetais em otite externa aguda In vitro antimicrobial activity of plants in Acute Otitis Externa

    Directory of Open Access Journals (Sweden)

    Janaina Cândida Rodrigues Nogueira

    2008-02-01

    Full Text Available Otite externa aguda é a inflamação do conduto auditivo externo, e plantas medicinais podem ser utilizadas, na cultura popular, para seu tratamento. OBJETIVO: Avaliar atividade antimicrobiana in vitro de Aleolanthus suaveolens, Caryophyllus aromaticus, Cymbopogon citratus, Matricaria chamomila, Pithecellobium avaremotemo, Plectranthus amboinicus e Ruta graveolens sobre agentes etiológicos de otite externa. CASUÍSTICA E MÉTODOS: A concentração inibitória mínima de extratos e óleos destas plantas foi obtida em amostras de otite externa. RESULTADOS: Staphylococcus aureus em 10 culturas, Pseudomonas aeruginosa em 8, Pseudomonas aeruginosa e Staphylococcus aureus, em associação, em 5 culturas e Candida albicans e Candida krusei em 4 culturas. P. aeruginosa foi resistente a todos os extratos e óleos essenciais testados; os extratos de A. suaveolens, P. avaremotemo e de R. graveolens foram inativos, o óleo essencial de C. aromaticus e M. chamomila foram ativos contra 3 cepas de S. aureus e as cepas de Candida; Sete das cepas de S. aureus foram sensíveis ao extrato de P. amboinicus, mas o óleo não mostrou atividade, 4 cepas de S.aureus e as cepas de Candida foram sensíveis ao óleo essencial de R. graveolens. CONCLUSÃO: Algumas plantas apresentaram resultados satisfatórios, dependendo do agente etiológico, porém se faz necessário estudos mais detalhados, para melhorar o aproveitamento destas plantas.Acute Otitis Externa is an inflammation of the outer auditory meatus, and according to popular saying, medicinal plant extracts can be used in its treatment. AIM: to assess the in vitro antimicrobial activity of the following plants: Aleolanthus suaveolens; Caryophyllus aromaticus; Cymbopogon citratus; Matricaria chamomila; Pithecellobium avaremotemo; Plectranthus amboinicus and Ruta graveolens on the germs that cause otitis externa. MATERIALS AND METHODS: the minimum inhibitory concentration of extracts and oils from these plants was

  18. Redução da dor em mulheres com osteoporose submetidas a um programa de atividade física Pain relief in women with osteoporosis after a physical activity program

    Directory of Open Access Journals (Sweden)

    Patricia Driusso

    2008-09-01

    Full Text Available Este estudo teve por objetivo avaliar a dor e o consumo de analgésicos em mulheres com osteoporose, após a realização de um programa de atividade física. Participaram do estudo 15 mulheres com média de idade 59±7,6 anos, com diagnóstico densitométrico em L2-L4 de osteoporose e que haviam feito uso de analgésicos para dorsalgia pelo menos três vezes por semana no mês precedente à avaliação inicial. A dor foi avaliada por questões extraídas do Osteoporosis Assessment Questionnaire, aplicadas antes e após um programa de atividade física; o escore variou de 0 (melhor, sem dor a 10 (pior, dor diária. O programa, que consistiu em caminhadas, exercícios livres de membros superiores e inferiores e relaxamento, foi realizado duas vezes por semana durante 28 semanas consecutivas. Os dados foram tratados estatisticamente. Comparando-se as pontuações obtidas, a dor apresentou uma diminuição significativa entre a avaliação inicial (7,33±3,05 e final (4,17±2,61, p=0,0007. Observou-se também uma redução no consumo de analgésicos. Esses resultados sugerem que o programa de atividade física foi efetivo para a diminuição da dor, contribuindo para a melhora da qualidade de vida das mulheres com osteoporose.This paper aimed at evaluating the effect of a physical activity program onto the level of pain as perceived by women with osteoporosis. Fifteen women (mean age 59±7.6 years old with bone-densitometry diagnosis of lumbar osteoporosis took part in the study; they all took analgesics at least thrice a week in the month prior to the study. Pain was assessed by questions extracted from the Osteoporosis Assessment Questionnaire both before and after the program; scores ranged from 0 (no pain to 10 (pain everyday. The program consisted of walking, lower and upper limb free exercises, massage, and relaxation, twice a week, during 28 weeks. Data were statistically analysed. A significant decrease in pain was found after the program

  19. Redox-active labile iron in fortified flours from the Brazilian market Ferro lábil redox-ativo em farinhas fortificadas do mercado brasileiro

    Directory of Open Access Journals (Sweden)

    Breno Pannia Espósito

    2007-08-01

    Full Text Available OBJECTIVE: To quantify the fraction of redox-active labile iron in iron-fortified flours acquired on the Brazilian market. METHODS: Samples of wheat flour, maize flour and breadcrumbs were extracted with buffers that mimic gastric juice, saliva and intestinal juice. Redox-active labile iron levels were assessed through the reaction of autoxidation of ascorbic acid catalyzed by iron in the presence of a fluorescence probe. RESULTS: Redox-active labile iron represents 1% to 9% of the total iron in the flour and breadcrumb samples, with the lowest values found under gastric juice conditions and the highest in the more alkaline media. Redox-active labile iron possibly arises from the decomposition of an iron-phytic acid complex. A positive correlation between redox-active labile iron and total iron was found in saline biomimetic fluids. CONCLUSION: Redox-active labile iron may be a risk factor for people with impaired antioxidant defenses, such as those who are atransferrinemic or iron overloaded (e.g. thalassemic. Total iron can be used to predict redox-active labile iron absorption at each stage of the gastrointestinal tract after ingestion of iron-fortified flours.OBJETIVO: Quantificar a porcentagem de ferro lábil redox ativo em farinhas fortificadas adquiridas no comércio popular. MÉTODOS: Amostras de farinha de trigo, fubá e rosca foram extraídas com tampões miméticos de suco gástrico, saliva e suco intestinal. Os níveis de ferro lábil redox ativo foram determinados por meio da reação de auto-oxidação do ácido ascórbico catalisada pelo ferro, em presença de uma sonda fluorimétrica. RESULTADOS: A fração de ferro lábil redox ativo representa entre 1% e 9% do ferro total nas farinhas estudadas, sendo os menores valores encontrados em condições miméticas do suco gástrico e os maiores nos meios mais alcalinos. Há indícios de que o ferro lábil redox ativo origina-se da decomposição de um complexo entre ferro e ácido f

  20. Benzyl 2-β-Glucopyranosyloxybenzoate, a New Phenolic Acid Glycoside from <em>Sarcandra glabraem>

    Directory of Open Access Journals (Sweden)

    Xudong Xu

    2012-05-01

    Full Text Available From the whole plant of <em>Sarcandra glabraem>, a new phenolic acid glycoside, benzyl 2-β-glucopyranosyloxybenzoate (1, together with seven known compounds including eleutheroside B1 (2, 5-<em>O>-caffeoylshikimic acid (3, (–-(7<em>S>, 8<em>R>-dihydrodehydro-diconiferyl alcohol (4, (–-(7<em>S>, 8<em>R>-dihydrodehydrodiconiferyl alcohol 9-, 9′- and 4-<em>O>-â-D-glucopyranoside (57, and (–-(7<em>S>, 8<em>R>-5-methoxydihydrodehydrodiconiferyl alcohol 4-<em>O>-β-D-glucopyranoside (8 was isolated. Their structures were elucidated by spectral analysis including 1D-, 2D-NMR and HR-ESI-MS. Compound 2 was found to exhibit potent cytotoxic activity against BGC-823 and A2780 cancer cell lines using MTT method with IC50 value of 2.53 and 1.85 µM, respectively.

  1. [Nine Equivalents of Nursing Manpower Use Score (NEMS): a study of its historical process].

    Science.gov (United States)

    Canabarro, Simone Travi; Velozo, Kelly Dayane Stochero; Eidt, Olga Rosária; Piva, Jefferson Pedro; Garcia, Pedro Celiny Ramos

    2010-09-01

    This study aims to describe, through an integrative review of literature, the historical trajectory of therapeutic intervention scores with emphasis on Nine Equivalents of Nursing Manpower Use Score in Intensive Care Units. The descriptors "Intensive care units" and "scales" were looked up in publications issued between 2000 and 2009. The terms selected were: "Nine Equivalents of Nursing Manpower Use Score" or "NEMS", "Unidade de Terapia Intensiva", "Therapeutic Intervention Scoring System-76", "Therapeutic Intervention Scoring System-28 or "TISS-28". As to the publications, "Medical Literature Analysis and Retrieval System Online" (MEDLINE) and "Literatura Latino-Americana e do Caribe em Ciências da Saúde" (LILACS) were selected Among the 295 papers reviewed, 18 were chosen, of which 55,5% were in English. The studies deal with NEMS (33,3%), Therapeutic Intervention Scoring System-76 (11,1%), TISS-28 (33,3%), among others. Research emphasized that NEMS has been a useful, operational and succinct tool.

  2. Interpreting force concept inventory scores: Normalized gain and SAT scores

    Directory of Open Access Journals (Sweden)

    Jeffrey J. Steinert

    2007-05-01

    Full Text Available Preinstruction SAT scores and normalized gains (G on the force concept inventory (FCI were examined for individual students in interactive engagement (IE courses in introductory mechanics at one high school (N=335 and one university (N=292 , and strong, positive correlations were found for both populations ( r=0.57 and r=0.46 , respectively. These correlations are likely due to the importance of cognitive skills and abstract reasoning in learning physics. The larger correlation coefficient for the high school population may be a result of the much shorter time interval between taking the SAT and studying mechanics, because the SAT may provide a more current measure of abilities when high school students begin the study of mechanics than it does for college students, who begin mechanics years after the test is taken. In prior research a strong correlation between FCI G and scores on Lawson’s Classroom Test of Scientific Reasoning for students from the same two schools was observed. Our results suggest that, when interpreting class average normalized FCI gains and comparing different classes, it is important to take into account the variation of students’ cognitive skills, as measured either by the SAT or by Lawson’s test. While Lawson’s test is not commonly given to students in most introductory mechanics courses, SAT scores provide a readily available alternative means of taking account of students’ reasoning abilities. Knowing the students’ cognitive level before instruction also allows one to alter instruction or to use an intervention designed to improve students’ cognitive level.

  3. Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate

    NARCIS (Netherlands)

    Wells, G.; Becker, J-C; Teng, J.; Dougados, M.; Schiff, M.; Smolen, J.; Aletaha, D.; van Riel, P. L. C. M.

    2009-01-01

    Objective: To validate and compare the definition of the Disease Activity Score 28 based on C-reactive protein (DAS28 (CRP)) to the definition based on erythrocyte sedimentation rate (ESR). Methods: Data were analysed from two randomised, double-blind, placebo-controlled trials of abatacept of 6-mon

  4. Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate.

    NARCIS (Netherlands)

    Wells, G.; Becker, J.C.; Teng, J.; Dougados, M.; Schiff, M.; Smolen, J.; Aletaha, D.; Riel, P.L.C.M. van

    2009-01-01

    OBJECTIVE: To validate and compare the definition of the Disease Activity Score 28 based on C-reactive protein (DAS28 (CRP)) to the definition based on erythrocyte sedimentation rate (ESR). METHODS: Data were analysed from two randomised, double-blind, placebo-controlled trials of abatacept of 6-mon

  5. Evaluating Damage Potential in Security Risk Scoring Models

    Directory of Open Access Journals (Sweden)

    Eli Weintraub

    2016-05-01

    Full Text Available A Continuous Monitoring System (CMS model is presented, having new improved capabilities. The system is based on the actual real-time configuration of the system. Existing risk scoring models assume damage potential is estimated by systems' owner, thus rejecting the information relying in the technological configuration. The assumption underlying this research is based on users' ability to estimate business impacts relating to systems' external interfaces which they use regularly in their business activities, but are unable to assess business impacts relating to internal technological components. According to the proposed model systems' damage potential is calculated using technical information on systems' components using a directed graph. The graph is incorporated into the Common Vulnerability Scoring Systems' (CVSS algorithm to produce risk scoring measures. Framework presentation includes system design, damage potential scoring algorithm design and an illustration of scoring computations.

  6. Healing activity of laser InGaAlP (660nm in rats Atividade cicatrizante do laser AlGaInP (660nm em ratos

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    Kelly Cristina Borges Tacon

    2011-10-01

    Full Text Available PURPOSE: To evaluate the effect the healing activity of diode laser Indium Gallium Aluminum Phosphorus (InGaAlP ë660nm on healing of surgical wounds in rats. METHODS: Fifty-four female Wistar rats were used, divided into three groups (n=18 and subdivided into three subgroups (n=6 to be studied in 5, 10 and 15th days after surgical procedures. The wound was induced in the dorsal-cervical using punch. The lesions were irradiated on alternate days with InGaAlP laser, the energy densities of 3J/cm² (L3 or 6J/cm² (L6. The control group received no irradiation. At 5, 10 and 15th days after surgery the animals were euthanized and the repair area was removed and histological sections were stained with hematoxylin-eosin and picrossírius. We evaluated macroscopic and histological lesions in the times cited, as well as morphometric analysis of angiogenesis and collagen content. RESULTS: The wound healing activity InGaAlP laser was evidenced by increased angiogenesis group L3 and L6 in relation to control group (CG at the 5th day (p=0.0001 and decreased polymorphonuclear infiltrate and hemorrhage (p=0.045 and p=0.07 respectively in the groups L3 and L6 in relation to control group (GC. On the 10 and 15th days was also observed in groups treated with laser L3 and L6 stimulation was pronounced fibroplasia (p=0.0003 and p=0.034 respectively when compared with the control group (CG. CONCLUSION: The InGaAlP laser acted positively on the healing of skin wounds in rats.OBJETIVO: Avaliar a atividade cicatrizante do laser diodo Alumínio Gálio Índio Fósforo (AlGaInP, ë660nm em feridas cutâneas induzida em ratos. MÉTODOS: Foram utilizados 54 ratos Wistar, fêmeas, divididos em três grupos (n=18 e subdivididos em três subgrupos (n=6 animais para serem estudados no 5, 10 e 15º dias após o procedimento cirúrgico. A ferida foi induzida em região dorso-cervical utilizando punch. As lesões foram irradiadas em dias alternados com laser AlGaInP, nas

  7. Gluteus maximus and semitendinosus activation during active prone hip extension exercises Ativação do glúteo máximo e semitendinoso durante exercícios de extensão do quadril em prono

    Directory of Open Access Journals (Sweden)

    ACL Sakamoto

    2009-08-01

    Full Text Available BACKGROUND: Gluteus maximus strengthening exercises are employed in clinical practice as options for the treatment of low back and sacroiliac disorders. However, no studies were found that investigated which were the best exercises to activate this muscle and justify its employment in physical therapy practice. OBJECTIVE: To quantify the electromyographic (EMG activity of the gluteus maximus and semitendinosus muscles during four modalities of therapeutic exercises. METHODS: Thirty-one participants (16 men, 15 women were selected. The EMG activities of the gluteus maximus and semitendinosus was recorded and quantified while the participants performed four modalities of therapeutic exercises, involving active prone hip extension in four positions: knee extension (KE, knee flexion (KF, lateral hip rotation and knee extension (LHRKE, and lateral hip rotation and knee flexion (LHR-KF. RESULTS: Repeated-measures ANOVAs showed that the addition of KF or LHR increased gluteus maximus activity, whereas, KE decreased the activation of this muscle. In contrast, the exercises performed with KE increased semitendinosus activity. CONCLUSIONS: Exercises performed with KF or LHR, or a combination of the two, may be effective choices for gluteus maximus strengthening, however both KF and LHR decreased semitendinosus activity. The exercises performed with KE appeared to be an acceptable choice for semitendinosus activation.CONTEXTUALIZAÇÃO: Exercícios para fortalecimento do glúteo máximo são empregados na prática clínica para tratamento de disfunções da coluna lombar e sacroilíaca. Entretanto, não foram encontrados estudos que investigaram os melhores exercícios para ativar esse músculo de forma a justificar a sua utilização na prática fisioterapêutica. OBJETIVO: Quantificar a atividade eletromiográgica (EMG dos músculos glúteo máximo e semitendinoso durante quatro modalidades de exercícios terapêuticos. MÉTODOS: Trinta e um

  8. The HEART score for chest pain patients

    NARCIS (Netherlands)

    Backus, B.E.

    2012-01-01

    The HEART score was developed to improve risk stratification in chest pain patients in the emergency department (ED). This thesis describes series of validation studies of the HEART score and sub studies for individual elements of the score. The predictive value of the HEART score for the occurrence

  9. Scoring and Standard Setting with Standardized Patients.

    Science.gov (United States)

    Norcini, John J.; And Others

    1993-01-01

    The continuous method of scoring a performance test composed of standardized patients was compared with a derivative method that assigned each of the 131 examinees (medical residents) a dichotomous score, and use of Angoff's method with these scoring methods was studied. Both methods produce reasonable means and distributions of scores. (SLD)

  10. Correlação entre Inventário de Depressão de Beck e cortisol urinário em diabéticos tipo 2 Correlación entre el inventario de Depresión de Beck y el cortisol urinario en diabeticos tipo 2 Correlation between urine cortisol and scores on the Beck Depression inventory in patients with type 2 diabetes

    Directory of Open Access Journals (Sweden)

    Alexandra Bulgarelli do Nascimento

    2009-01-01

    Full Text Available OBJETIVO: Verificar a correlação entre o cortisol urinário e o Inventário de Depressão de Beck em diabéticos do tipo 2. MÉTODOS: O cortisol urinário foi avaliado em uma amostra composta por 40 pacientes da Liga de Controle de Diabetes da Disciplina de Endocrinologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo e para a avaliação dos sintomas de depressão foi aplicado o Inventário de Depressão de Beck. RESULTADOS: Alta confiabilidade para o Inventário de Depressão de Beck(Alfa de Cronbach=0,920e correlação significativa foi observada entre cortisol urinário e Inventário de Depressão de Beck(Spearman,r=0.523,pOBJETIVO: Verificar la correlación entre el cortisol urinario y el Inventario de Depresión de Beck en diabéticos del tipo 2. MÉTODOS: El cortisol urinario fue evaluado en una muestra compuesta por 40 pacientes de la Liga de Control de Diabetes de la Disciplina de Endocrinología del Hospital de las Clínicas de la Facultad de Medicina de la Universidad de Sao Paulo y para la evaluación de los síntomas de depresión fue aplicado el Inventario de Depresión de Beck. RESULTADOS: Alta confiabilidad para el Inventario de Depresión de Beck(Alfa de Cronbach=0,920 y correlación significativa observada entre el cortisol urinario e Inventario de Depresión de Beck (Spearman,r=0.523,pOBJECTIVE: To determine the relationship between urinary cortisol and scores on the Beck Depression Inventory in type 2 diabetics. METHODS: The sample consisted of 40 patients with type 2 diabetes from the diabetes control league of the discipline of endocrinology of the HCFM-USP. Measures consisted of urinary cortisol and depression symptoms using the Beck Depression Inventory. RESULTS: The Beck Depression Inventory had a Cronbach's alpha of 0.92. There was a statistically significant correlation between urinary cortisol and scores on the Beck Depression Inventory (Spearman r = 0.52, p < .001. CONCLUSIONS: The

  11. A Comparison of the Diabetes Risk Score in HIV/AIDS Patients on Highly Active Antiretroviral Therapy (HAART and HAART-Naive Patients at the Limbe Regional Hospital, Cameroon.

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    Christian Akem Dimala

    Full Text Available Highly active antiretroviral therapy (HAART has been associated with dysglycaemia. However, there is scarce data on the risk of developing diabetes mellitus (DM in HIV/AIDS patients in Africa.Primarily to quantify and compare the risk of having diabetes mellitus in HIV/AIDS patients on HAART and HAART-naïve patients in Limbe, Cameroon; and secondarily to determine if there is an association between HAART and increased DM risk.A cross-sectional study was conducted at the Limbe Regional Hospital HIV treatment center between April and June 2013, involving 200 HIV/AIDS patients (100 on first-line HAART regimens for at least 12 months matched by age and gender to 100 HAART-naïve patients. The Diabetes Risk Score (DRS was calculated using a clinically validated model based on routinely recorded primary care parameters. A DRS ≥ 7% was considered as indicative of an increased risk of developing DM.The median DRS was significantly higher in patients on HAART (2.30% than in HAART-naïve patients (1.62%, p = 0.002. The prevalence of the increased DM risk (DRS ≥ 7% was significantly higher in patients on HAART, 31% (95% CI: 22.13-41.03 than in HAART-naïve patients, 17% (95% CI: 10.23-25.82, p = 0.020. HAART was significantly associated with an increased DM risk, the odds ratio of the HAART group compared to the HAART-naïve group was 2.19 (95% CI: 1.12-4.30, p = 0.020. However, no association was found after adjusting for BMI-defined overweight, hypertension, age, sex, family history of DM and smoking (Odds ratio = 1.22, 95% CI: 0.42-3.59, p = 0.708. Higher BMI and hypertension accounted for the increased risk of DM in patients on HAART. Also, more than 82% of the participants were receiving or had ever used Zidovudine based HAART regimens.HIV/AIDS patients on HAART could be at a greater risk of having DM than HAART-naïve patients as a result of the effect of HAART on risk factors of DM such as BMI and blood pressure.

  12. Bias Adjusted Precipitation Threat Scores

    Directory of Open Access Journals (Sweden)

    F. Mesinger

    2008-04-01

    Full Text Available Among the wide variety of performance measures available for the assessment of skill of deterministic precipitation forecasts, the equitable threat score (ETS might well be the one used most frequently. It is typically used in conjunction with the bias score. However, apart from its mathematical definition the meaning of the ETS is not clear. It has been pointed out (Mason, 1989; Hamill, 1999 that forecasts with a larger bias tend to have a higher ETS. Even so, the present author has not seen this having been accounted for in any of numerous papers that in recent years have used the ETS along with bias "as a measure of forecast accuracy".

    A method to adjust the threat score (TS or the ETS so as to arrive at their values that correspond to unit bias in order to show the model's or forecaster's accuracy in extit{placing} precipitation has been proposed earlier by the present author (Mesinger and Brill, the so-called dH/dF method. A serious deficiency however has since been noted with the dH/dF method in that the hypothetical function that it arrives at to interpolate or extrapolate the observed value of hits to unit bias can have values of hits greater than forecast when the forecast area tends to zero. Another method is proposed here based on the assumption that the increase in hits per unit increase in false alarms is proportional to the yet unhit area. This new method removes the deficiency of the dH/dF method. Examples of its performance for 12 months of forecasts by three NCEP operational models are given.

  13. Habituation of exploratory activity in aged rats: effects of pyritinol Habituação da atividade exploratória em ratos idosos: efeitos do piritinol

    Directory of Open Access Journals (Sweden)

    Roberto DeLucia

    2005-03-01

    Full Text Available Acetylcholine (Ach is a neurotransmitter considered to play a critical role in processes underlying behavior, learning, and memory. Pyritinol (pyrithioxine, Encephabolâ, PRT is a nootropic drug that increases cholinergic transmission in the central nervous system. Behavioral habituation following multiple exposures to an open field is an experimental paradigm frequently used to assess the cognitive actions of drugs. In this paradigm the decrease of exploratory activity as a function of repeated exposure to the same environment is taken as an index memory. In the present study, effects PRT administrated to aged rats in powder form added to the diet (200 mg /kg / day, p.o., for 14 days were evaluated in the habituation to an open field. A total of 18 aged rats were randomly assigned to one of two groups control (vehicle-treated rats, n = 8 and experimental group (PRT-treated rats, n = 10 and were used in the following procedure. In the exploratory task, the post-training treatment with PRT significantly decreased the number of total area crossings and rears when compared to the control group, indicating habituation. PRT treatment enhanced retention in the total number of area crossings and rears when compared with control animals. Taken together, the data of present study suggest that muscarinic cholinergic systems could be involved in the effect of PRT in habituation of exploratory activity to an open field in aged rats.A acetilcolina é um neurotransmissor que desempenha considerável papel crítico nos processos subjacentes ao comportamento, aprendizagem e memória. Piritinol (piritioxina, Encefabolâ, PRT é um fármaco nootrópico que aumenta a transmissão colinérgica no sistema nervoso central. Habituação comportamental seguida de múltipla exposição no campo aberto é um paradigma experimental freqüentemente usado na avaliação das ações cognitivas de fármacos. Neste paradigma, a diminuição da atividade exploratória em fun

  14. Training for Defense? From Stochastic Traits to Synchrony in Giant Honey Bees (<em>Apis dorsataem>

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    Gerald Kastberger

    2012-08-01

    Full Text Available In Giant Honey Bees, abdomen flipping happens in a variety of contexts. It can be either synchronous or cascaded, such as in the collective defense traits of shimmering and rearing-up, or it can happen as single-agent behavior. Abdomen flipping is also involved in flickering behavior, which occurs regularly under quiescent colony state displaying singular or collective traits, with stochastic, and (semi- synchronized properties. It presumably acts via visual, mechanoceptive, and pheromonal pathways and its goals are still unknown. This study questions whether flickering is preliminary to shimmering which is subject of the <em>fs em>(flickering-shimmering-transition> hypothesis? We tested the respective prediction that trigger sites (<em>ts> at the nest surface (where shimmering waves had been generated show higher flickering activity than the alternative non-trigger sites (<em>nts>. We measured the flickering activity of <em>ts>- and <em>nts>-surface bees from two experimental nests, before and after the colony had been aroused by a dummy wasp. Arousal increased rate and intensity of the flickering activity of both <em>ts>- and <em>nts> cohorts (P < 0.05, whereby the flickering intensity of <em>ts>-bees were higher than that of <em>nts>-bees (P < 0.05. Under arousal, the colonies also increased the number of flickering-active <em>ts>- and <em>nts>-cohorts (P < 0.05. This provides evidence that cohorts which are specialist at launching shimmering waves are found across the quiescent nest zone. It also proves that arousal may reinforce the responsiveness of quiescent curtain bees for participating in shimmering, practically by recruiting additional trigger site bees for expanding repetition of rate and intensity of shimmering waves. This finding confirms the <em>fs-transition> hypothesis and constitutes evidence that flickering is part of a basal colony-intrinsic information system

  15. Violência e atividade sexual desprotegida em adolescentes menores de 15 anos Violence and unsafe sexual activity of adolescents under 15 years of age

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    Sérgio Araujo Martins Teixeira

    2010-01-01

    Full Text Available OBJETIVO: Identificar fatores associados à atividade sexual desprotegida em adolescentes femininas menores de 15 anos. MÉTODOS: Estudo observacional de corte transversal com adolescentes femininas menores de 15 anos e sexualmente ativas, atendidas em um ambulatório público de ginecologia. Os instrumentos de coleta de dados foram: entrevista semiestruturada para dados pessoais e de sexualidade, e exame clínico-laboratorial para diagnóstico de doenças sexualmente transmissíveis. Os dados foram analisados por meio de testes de frequência, de associação de variáveis com p OBJECTIVE: To identify factors associated with unprotected sexual activity in female adolescents younger than 15 years. METHODS: Observational cross-sectional trial with female teenagers less than 15 years-old and sexually active, attended at a public gynecology clinic. Instruments for data collection were: semi-structured interviews for personal data and about sexuality as well as clinical examination and laboratory tests for diagnosis of sexually transmitted diseases. Data were analyzed by testing of frequency, association of variables with p <0.05 and multiple correspondence analysis. RESULTS: One hundred adolescents between 11 and 14 years of age sexually active were interviewed and examined, 71% declared themselves black, one-third were behind in school, 80% began sexual activity before 13 years of age , 58% reported having been victims of violence in the intrafamily environment and 13% had suffered sexual abuse, 77% did not use condoms regularly and 22% had STDs. Unprotected sexual activity occurred more frequently with the first sexual intercourse before 13 years of age, commercial sexual exploitaion, multiple sexual partners, intrafamily violence and school delay, in addition to be black, to unexpected pregnancy and have STDs. CONCLUSION: The multiple violence suffered by teenagers, including structural, intrafamily and sexual, contribute to increase their

  16. Fall-related factors among less and more active older outpatients Fatores associados a quedas em pacientes idosos ambulatoriais menos ativos e mais ativos

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    Monica R. Perracini

    2012-04-01

    Full Text Available BACKGROUND: Fall-related factors in older adults with different levels of physical activity, within a multidimensional approach, have not been widely investigated. OBJECTIVE: To explore fall-related factors among older adults with different physical activity levels. METHODS: A cross-sectional, exploratory study with 118 older adult outpatients. Participants who reported at least one fall in the previous 12 months were considered fallers. The activity level was assessed through the Human Activity Profile. A cutoff of 54 points was used to define the less active group and the more active group. A multidimensional questionnaire and a set of physical functioning tests were applied. RESULTS: Fall prevalence was lower among the more active older adults (47.4% when compared with the less active older adults (71.4% (pCONTEXTUALIZAÇÃO: Fatores relacionados a quedas em idosos com diferentes níveis de atividade física, por meio de uma abordagem multidimensional, não têm sido amplamente investigados. OBJETIVO: Explorar os fatores relacionados a quedas em idosos com diferentes níveis de atividade física. MÉTODOS: Estudo transversal exploratório com 118 pacientes idosos ambulatoriais. Participantes que relataram ao menos uma queda nos últimos 12 meses foram considerados caidores. O nível de atividade física foi avaliado por meio do Perfil de Atividade Humana (PAH. O ponto de corte de 54 pontos foi usado para definir o grupo menos ativo e o grupo mais ativo. Um questionário multidimensional e uma bateria de testes físico-funcionais foram utilizados. RESULTADOS: A prevalência de quedas foi menor no grupo de idosos mais ativos (47,4% quando comparada à dos idosos menos ativos (71,4% (p<0,013. A análise de regressão logística multivariada identificou que, no grupo mais ativo, ter caído estava associado a sintomas depressivos (OR=0,747, IC95%=0,575-0,970; p=0,029, preocupação em cair (OR=1,17, IC95%=1,072-1,290; p=0,001 e velocidade de

  17. Re-Scoring the Game’s Score

    DEFF Research Database (Denmark)

    Gasselseder, Hans-Peter

    2014-01-01

    that a compatible integration of global and local goals in the ludonarrative contributes to a motivational-emotional reinforcement that can be gained through musical feedback. Shedding light on the implications of music dramaturgy within a semantic ecology paradigm, the perception of varying relational attributes......This study explores immersive presence as well as emotional valence and arousal in the context of dynamic and non-dynamic music scores in the 3rd person action-adventure video game genre while also considering relevant personality traits of the player. 60 subjects answered self......-report questionnaires of experiential states each time after playing the game 'Batman: Arkham City' in one of three randomized conditions accounting for [1] dynamic music, [2] non-dynamic music/low arousal potential and [3] non-dynamic music/high arousal potential, aiming to manipulate emotional arousal and structural...

  18. Disclosure Risk from Factor Scores

    Directory of Open Access Journals (Sweden)

    Drechsler Jörg

    2014-03-01

    Full Text Available Remote access can be a powerful tool for providing data access for external researchers. Since the microdata never leave the secure environment of the data-providing agency, alterations of the microdata can be kept to a minimum. Nevertheless, remote access is not free from risk. Many statistical analyses that do not seem to provide disclosive information at first sight can be used by sophisticated intruders to reveal sensitive information. For this reason the list of allowed queries is usually restricted in a remote setting. However, it is not always easy to identify problematic queries. We therefore strongly support the argument that has been made by other authors: that all queries should be monitored carefully and that any microlevel information should always be withheld. As an illustrative example, we use factor score analysis, for which the output of interest - the factor loading of the variables - seems to be unproblematic. However, as we show in the article, the individual factor scores that are usually returned as part of the output can be used to reveal sensitive information. Our empirical evaluations based on a German establishment survey emphasize that this risk is far from a purely theoretical problem.

  19. Score lists in multipartite hypertournaments

    CERN Document Server

    Pirzada, Shariefuddin; Iványi, Antal

    2010-01-01

    Given non-negative integers $n_{i}$ and $\\alpha_{i}$ with $0 \\leq \\alpha_{i} \\leq n_i$ $(i=1,2,...,k)$, an $[\\alpha_{1},\\alpha_{2},...,\\alpha_{k}]$-$k$-partite hypertournament on $\\sum_{1}^{k}n_{i}$ vertices is a $(k+1)$-tuple $(U_{1},U_{2},...,U_{k},E)$, where $U_{i}$ are $k$ vertex sets with $|U_{i}|=n_{i}$, and $E$ is a set of $\\sum_{1}^{k}\\alpha_{i}$-tuples of vertices, called arcs, with exactly $\\alpha_{i}$ vertices from $U_{i}$, such that any $\\sum_{1}^{k}\\alpha_{i}$ subset $\\cup_{1}^{k}U_{i}^{\\prime}$ of $\\cup_{1}^{k}U_{i}$, $E$ contains exactly one of the $(\\sum_{1}^{k} \\alpha_{i})!$ $\\sum_{1}^{k}\\alpha_{i}$-tuples whose entries belong to $\\cup_{1}^{k}U_{i}^{\\prime}$. We obtain necessary and sufficient conditions for $k$ lists of non-negative integers in non-decreasing order to be the losing score lists and to be the score lists of some $k$-partite hypertournament.

  20. Haemolytic activity of Actinobacillus actinomycetemcomitans strains on different blood types Atividade hemolítica de cepas de Actinobacillus actinomycetemcomitans em diferentes tipos sanguíneos

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    Mario Julio Avila-Campos

    1995-06-01

    Full Text Available Haemolytic activity of sixty nine Actinobacillus actinomycetemcomitans strains on different animal and human blood types was examined by using a trypticase soy agar supplemented with yeast extract (0.5%. Blood types used were: rabbit, sheep and human (A, Rh+; A, Rh-; B, Rh+; B, Rh-; O, Rh+; O, Rh-; AB, Rh+; AB, Rh- groups. Plates were inoculated and, incubated in microaerophilic conditions, at 37ºC, for 48 h. The haemolytic activity of the tested strains was characterized as alpha-haemolysis. Only two isolates were not haemolytic on all blood types (2.9%, two strains were haemolytic only on human blood (one strain on AB, Rh+ group and another one on A, Rh+ and AB, Rh+ groups. No specificity between haemolysin produced by the tested strains and blood type was observed.A atividade hemolítica de 69 cepas de Actinobacillus actinomycetemcomitans foi determinada em diferentes tipos de sangue animal e humano, usando como meio base ágar de soja tripticaseina, suplementado com extrato de levedura (0,5%. Foram utilizados sangue de coelho, carneiro e humano (grupos A, Rh+; A, Rh-; B, Rh+; B, Rh-; O, Rh+; O, Rh-; AB, Rh+ e AB, Rh-. As placas foram inoculadas e, incubadas em condições de microaerofilia, a 37ºC, por 48 h. A atividade hemolítica das cepas testadas foi caracterizada como alfa-hemólise. Somente dois (2,9% isolados não hemolisaram todos os tipos sanguíneos, duas cepas hemolisaram somente sangue humano (uma o grupo AB, Rh+ e outra os grupos A, Rh+ e AB, Rh+. Não foi observada alguma especificidade entre as hemolisinas produzidas e os tipos de sangue utilizados.

  1. Physical activity and eating habits in public high schools from different regions in Brazil: the Saude na Boa project Atividade física e hábitos alimentares em escolas públicas do ensino médio em diferentes regiões do Brasil: o projeto Saúde na Boa

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    Markus Vinicius Nahas

    2009-06-01

    Full Text Available PURPOSE: To analyze physical activity and dietary patterns of adolescents and young adults attending evening classes in high schools at two socioeconomic and culturally contrasting Cities in Brazil: Recife (in northern Brazil and Florianopolis (in southern Brazil. METHODS: This is a cross-sectional analysis (baseline data of a school-based randomized trial (the Saude na Boa project, including 2,147 students (15-24 years of age; 55.7% females from 10 schools in each city, pair-matched by size and location. Data were collected by questionnaire. RESULTS: Males were more active than females (pOBJETIVO: Analisar os padrões de atividade física e hábitos alimentares de adolescentes e jovens adultos matriculados no ensino noturno de escolas públicas do ensino médio em duas cidades com características culturais e socioeconômicas diversas no Brasil: Recife (Região Nordeste e Florianópolis (Região Sul. MÉTODOS: Estudo observacional transversal dos dados de base de uma intervenção escolar randomizada (Projeto Saúde na Boa, incluindo 2.147 estudantes (15-24 anos; 55,7% do sexo feminino de 10 escolas em cada uma das cidades, pareadas por tamanho e localização. Os dados foram coletados por questionário. RESULTADOS: Os rapazes foram mais ativos que as moças (p<0,001 em todas as três medidas de atividade física no questionário: dias/sem com 60+min de atividade física moderada a vigorosa (AFMV - rapazes 3,8 d/sem (DP=2,3, moças 3,2 d/sem (DP=2,4; caminhar ou pedalar para a escola - rapazes 4,5 d/sem (DP=2,4, moças 4,1 d/sem (DP=2,4; e exercícios de força muscular - rapazes 2,3 d/sem (DP=2,5, moças 0,8 d/sem (DP=1,7. A prevalência de inatividade física (zero dias/sem com 60+min de AFMV foi significativamente mais alta em Recife (p<0,001. A frequência de consumo de frutas foi mais elevada em Recife do que em Florianópolis (p<0,001, não havendo diferença no consumo de legumes e verduras (p=0,28 e consumo de refrigerantes (p=0,09. Em

  2. Haemophilia Joint Health Score in healthy adults playing sports.

    Science.gov (United States)

    Sluiter, D; Foppen, W; de Kleijn, P; Fischer, K

    2014-03-01

    To evaluate outcome of prophylactic clotting factor replacement in children with haemophilia, the Haemophilia Joint Health Score (HJHS) was developed aiming at scoring early joint changes in children aged 4-18. The HJHS has been used for adults on long-term prophylaxis but interpretation of small changes remains difficult. Some changes in these patients may be due to sports-related injuries. Evaluation of HJHS score in healthy adults playing sports could improve the interpretation of this score in haemophilic patients. The aim of this study was to evaluate the HJHS scores in a cohort of young, healthy men participating in sports. Concomitant with a project collecting MRI images of ankles and knees in normal young adults, HJHS scores were assessed in 30 healthy men aged 18-26, participating in sports one to three times per week. One physiotherapist assessed their clinical function using the HJHS 2.1. History of joint injuries was documented. MRI images were scored by a single radiologist, using the International Prophylaxis Study Group additive MRI score. Median age of the study group was 24.3 years (range 19.0-26.4) and median frequency of sports activities was three times per week (range 1-4). Six joints (five knees, one ankle) had a history of sports-related injury. The median overall HJHS score was 0 out of 124 (range 0-3), with 60% of subjects showing no abnormalities on HJHS. All joints were normal on MRI. These results suggest that frequent sports participation and related injuries are not related with abnormalities in HJHS scores.

  3. Relações entre atributos do solo e atividade de formigas em restingas Relationship among soil attributes and ant activity in restinga soils

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    João Bosco Vasconcellos Gomes

    2010-02-01

    Full Text Available Em solos de restinga de constituição areno-quartzosa aumenta a influência da fração orgânica e da atividade biológica em funções-chave dos solos, como a capacidade de reciclar e armazenar nutrientes. A análise de atributos do solo e da fauna edáfica em sítios sob diferentes coberturas vegetais é importante para entender o comportamento desses ambientes. Neste estudo, avaliaram-se atributos químicos, físicos e microbiológicos do solo e suas relações com a população de formigas de sítios de restinga sob diferentes coberturas vegetais no Estado de Sergipe. Foram coletadas amostras em seis coberturas vegetais (três sítios por cobertura, sendo quatro na área Caju (mata, capim-gengibre, coqueiral e capoeira e duas na área Pirambu (mata de topo de duna e mata de sopé de duna. As análises químicas foram feitas em amostras coletadas nas camadas de 0-5 e 5-20 cm, e a atividade microbiana, avaliada por meio da hidrólise do diacetato de fluoresceína, foi determinada em amostras coletadas a 0-10 cm. A massa de fragmentos orgânicos foi avaliada em diferentes profundidades. Na avaliação das comunidades de formigas foram consideradas aquelas com atividade na superfície do solo. Na comparação entre os sítios foi utilizada a análise de componentes principais. Os atributos de compartimentos orgânicos (C orgânico, C orgânico dissolvido e fragmentos orgânicos foram muito sensíveis à modificação da cobertura vegetal nos sítios do Caju, isolando os sítios sob mata dos alterados e os sítios sob capim-gengibre daqueles sob capoeira e coqueiral. Atributos da solução do solo influenciáveis pelo spray marinho (condutividade elétrica e concentração de K, Na e Mg isolaram os sítios de Pirambu dos sítios do Caju. Os grupos de formiga mostraram elevado nível de especialização. A análise de correspondência canônica apontou baixa percentagem da variância da distribuição desses grupos e isolou os sítios de mata

  4. Biomassa e atividades microbianas em solo sob pastagem com diferentes lotações de ovinos Biomass and microbial activity in pasture soil under different sheep grazing pressure

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    Martha Regina Lucizano Garcia

    2007-04-01

    Full Text Available Os efeitos da lotação de animais na produção de ovinos têm sido bastante estudados. No entanto, informações sobre seus efeitos na biomassa e nas atividades microbianas e, em conseqüência, na fertilidade do solo de pastagens são escassas. Neste trabalho, os efeitos da lotação de ovinos (LO na biomassa e nas atividades microbianas responsáveis pela transformação dos compostos do C e N em solo de clima subtropical foram avaliados. As amostras de solo foram coletadas nas camadas de 0-10 e 10-20 cm de pastos com baixa LO (5 animais ha-1, alta LO (40-50 animais ha-1 e com ausência de animais, em um delineamento inteiramente casualizado em parcelas subdivididas, com seis repetições. Os maiores valores de biomassa microbiana e das atividades respiratória, nitrificante e enzimática (urease e protease foram encontrados nos solos dos pastos com baixa LO. Estes pastos também acumularam as maiores quantidades de matéria orgânica e N total. Essas variáveis foram reduzidas nos pastos sem animais ou com alta LO. Vegetação descontínua e intensa mineralização podem ter acarretado a diminuição dessas variáveis nos pastos com alta LO. Alta correlação foi obtida entre matéria orgânica, C orgânico e N total com as quantidades de biomassa microbiana e a atividade enzimática. A camada de 0-10 cm apresentou valores maiores das variáveis estudadas do que os encontrados na camada de 10-20 cm.The effect of grazing pressure in sheep production has been studied, but not in relation to soil microbiological parameters or the consequences on soil fertility. The effect of grazing pressure (GP by sheep on biomass and microbial activity related to C and N compounds cycling in subtropical region soil was studied. Soil samples were collected from the 0-10 cm and 10-20 cm layers in pastures with low GP (5 animals ha-1, high GP (40-50 animals ha-1 and in absence of animals, in a completely randomized design with 6 replicates. The highest values

  5. Antioxidant Profile of <em>Trifolium pratenseem> L.

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    Heidy Schwartsova

    2012-09-01

    Full Text Available In order to examine the antioxidant properties of five different extracts of <em>Trifolium pratenseem> L. (Leguminosae leaves, various assays which measure free radical scavenging ability were carried out: 1,1-diphenyl-2-picrylhydrazyl, hydroxyl, superoxide anion and nitric oxide radical scavenger capacity tests and lipid peroxidation assay. In all of the tests, only the H2O and (to some extent the EtOAc extracts showed a potent antioxidant effect compared with BHT and BHA, well-known synthetic antioxidants. In addition, <em>in vivo em>experiments were conducted with antioxidant systems (activities of GSHPx, GSHR, Px, CAT, XOD, GSH content and intensity of LPx in liver homogenate and blood of mice after their treatment with extracts of <em>T. pratenseem> leaves, or in combination with CCl4. Besides, in the extracts examined the total phenolic and flavonoid amounts were also determined, together with presence of the selected flavonoids: quercetin, luteolin, apigenin, naringenin and kaempferol, which were studied using a HPLC-DAD technique. HPLC-DAD analysis showed a noticeable content of natural products according to which the examined <em>Trifolium pratenseem> species could well be regarded as a promising new source of bioactive natural compounds, which can be used both as a food supplement and a remedy.

  6. Efeitos fisiológicos agudos da taurina contida em uma bebida energética em indivíduos fisicamente ativos Acute physiological effects of taurine content of an energy drink in physically active subjects

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    Tatyana Dall' Agnol

    2009-04-01

    Full Text Available Segundo a Secretaria de Vigilância Sanitária do Ministério da Saúde, bebidas energéticas são identificadas como compostos líquidos prontos para o consumo, sendo estas constituídas de carboidratos, taurina, cafeína, glucoronolactona, inositol e vitaminas do complexo B. Existem poucas pesquisas sobre o uso de taurina contida em bebidas energéticas relacionado com a melhora de desempenho. Este trabalho teve como objetivo analisar as respostas metabólicas e hemodinâmicas decorrentes da administração da associação de taurina e cafeína durante teste ergoespirométrico em indivíduos fisicamente ativos. Para esse fim, 20 indivíduos do sexo masculino, 26 ± 4,32 anos e índice de massa corporal 23,79 ± 2,95, praticantes de atividades aeróbicas, foram submetidos a duas sessões de testes em cicloergômetro ligado a analisador metabólico de gases. O esquema das sessões foi duplo- cego e 60 minutos antes do início dos testes foi oferecida bebida experimental ou bebida placebo. Durante os testes, foram mensuradas: frequência cardíaca (FC, pressão arterial sistólica (PAS e diastólica (PAD, lactato sanguíneo (Lac, percepção subjetiva de esforço por escala de Borg (PSE, consumo máximo de oxigênio (VO2máx, consumo de oxigênio no ponto de compensação respiratório (RCP, tempo de exercício (TE e carga de trabalho (CAR. Para a análise dos dados, foi realizado um teste t pareado (p ≤ 0,05. Na carga de trabalho, os resultados indicaram que houve aumento de 10 watts com a administração da bebida experimental, contudo, sem significância estatística (BE: 342 ± 40,60; P: 332,50 ± 56,83. Os principais resultados deste estudo indicam que a administração de taurina contida em bebida energética não influenciou os resultados das variáveis investigadas. Assim, podemos concluir que a dose de 2g utilizada não foi capaz de aumentar o desempenho.According to the Sanitary Surveillance Agency of the Ministry of Health

  7. Effect of Dieckol, a Component of <em>Ecklonia cavaem>, on the Promotion of Hair Growth

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    Sang-Cheol Kim

    2012-05-01

    Full Text Available This study was conducted to evaluate the effect of <em>Ecklonia cavaem>, a marine alga native to Jeju Island in Korea, on the promotion of hair growth. When vibrissa follicles were cultured in the presence of <em>E. cavaem> enzymatic extract (which contains more than 35% of dieckol for 21 days, <em>E. cavaem> enzymatic extract increased hair-fiber length. In addition, after topical application of the 0.5% <em>E. cavaem> enzymatic extract onto the back of C57BL/6 mice, anagen progression of the hair-shaft was induced. The treatment with <em>E. cavaem> enzymatic extract resulted in the proliferation of immortalized vibrissa dermal papilla cells (DPC. Especially, dieckol, among the isolated compounds from the <em>E. cavaem> enzymatic extract, showed activity that increased the proliferation of DPC. When NIH3T3 fibroblasts were treated with the <em>E. cavaem> enzymatic extract and the isolated compounds from the <em>E. cava> enzymatic extract, the <em>E. cavaem> enzymatic extract increased the proliferation of NIH3T3 fibroblasts, but the isolated compounds such as eckol, dieckol, phloroglucinol and triphlorethol-A did not affect the proliferation of NIH3T3 fibroblasts. On the other hand, the <em>E. cavaem> enzymatic extract and dieckol significantly inhibited 5α-reductase activity. These results suggest that dieckol from <em>E. cavaem> can stimulate hair growth by the proliferation of DPC and/or the inhibition of 5α-reductase activity.

  8. Atividades citotóxica e hemolítica em Escherichia coli uropatogênicas Citotoxic and hemolytic activities of uropathogenic Escherichia coli

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    João Ramos Costa Andrade

    1988-06-01

    Full Text Available Estudamos 59 Escherichia coli uropatogênicas (ECUP obtidas de pacientes com infecção urinária e 30 E. coli originárias das fezes de indivíduos normais. Cada amostra originou-se de um paciente ou controle. Verificamos que 44% e 3,3% respectivamente eram hemolíticas em meio sólido segundo a origem. Apenas 15% das ECUP hemolíticas produziram alfa-hemolisina, isoladamente ou em associação com ß-hemolisina. A alfa-hemolisina correspondeu a 92% das amostras com atividade hemolítica. Não encontramos correlação entre títulos de alfa-hemolisina e o sítio de origem das ECUP (infecção alta ou baixa. Em 71% das ECUP e 30% das E. coli fecais detectamos a produção de citotoxina com ação citocida para linhagens celulares epitelióides como Vero, He-La e Hep-2 e pouco ativa para fibroblastos de embrião de galinha. A produção desta citotoxina não apresenta correlação com a síntese de hemolisinas. Não verificamos associação entre títulos citotóxicos e origem das ECUP. Certas características biológicas desta citotoxina como a resposta morfológica que determina nas células, o aumento dos títulos citotóxicos com o tempo, sua atividade citocida irreversível e sua termolabilidade sugerem analogia com a Verotoxina (VT de E. coli. As células afetadas pela citoxina inicialmente mostram aspecto estrelado, tornam-se arredondadas e finalmente desprendem-se do seu suporte. É sugerido que a produção de citotoxina por E. coli aderidas às mucosas do trato urinário possa contribuir para a agressão ao uroepitélio.Fifty nine Escherichia coli strains obtained from patients with upper or lower urinary tract infections (UTI and 30 E. coli strains isolated from stools of healthy individuals were tested for hemolytic and totoxic activities. Forty four percent of uropathologenic e. coli (UPEC and 3.3% of fecal E. coli were hemolytic. Among the hemolytic UPEC, 92% produced x-hemolysin. A cytotoxic activity was detected in culture

  9. Atividade da redutase do nitrato e fluorescência da clorofila a em mamoeiro Nitrate reductase activity and chlorophyll a fluorescence in papaya

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    Renata Venturim Fontes

    2008-03-01

    Full Text Available O objetivo do presente trabalho foi correlacionar a atividade da redutase do nitrato e a eficiência fotoquímica máxima do fotossistema II (FSII, expressa pela razão F V/F M (F V = fluorescência variável e F M = fluorescência máxima, em mamoeiro (Carica papaya L. cv. Tainung 01 e Sunrise Solo 72/12 em condições de campo. O potencial fotoquímico do FSII foi medido in situ em folhas adaptadas ao escuro. Depois, nas mesmas folhas, foi medida a atividade da enzima. Não houve diferença significativa entre a eficiência fotoquímica máxima do FSII entre as cultivares Tainung 01 e Sunrise Solo 72/12, porém a atividade da redutase do nitrato foi notoriamente maior na primeira. A atividade da redutase do nitrato foi altamente correlacionada à eficiência fotoquímica máxima do FS II tanto na cv. Tainung 01 (coeficiente de correlação r= 0,740 e coeficiente de determinação r²= 0,706 quanto na Sunrise Solo 72/12 (coeficiente de correlação r= 0,960 e coeficiente de determinação r²= 0,945. Esses resultados sugerem que há uma correlação entre a fluorescência da clorofila a e a atividade da redutase do nitrato nessas plantas.The objective of the present work was to connect the nitrate reductase activity and the photochemical efficiency of the photosystem II (PSII, measured as F V/F M, in papaya (Carica papaya L. cv. Tainung 01 and Sunrise Solo 72/12 in field conditions. The photochemical potential of PSII was measured in situ on attached leaves that had been dark adapted, prior to the fluorescence measurement. After, in same leaves, the enzyme activity was measured. There was not significant difference among the photochemical efficiency of PSII between cv. Tainung 01 and Sunrise Solo 72/12, even so, the activity of the enzyme was markedly higher in cv. Tainung 01 than in cv. Sunrise Solo 72/12. The nitrate redutase activity was highly correlated with the photochemical efficiency of the PSII in both cv. Tainung 01 (coefficient of

  10. Briareolate Esters from the Gorgonian <em>Briareum asbestinumem>

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    Lyndon M. West

    2012-08-01

    Full Text Available Two new briarane diterpenoids briareolate esters J (1 and K (2 were isolated from the methanolic extract of the octocoral <em>Briareum> asbestinum em>collected off the coast of Boca Raton, Florida. The structures of briaranes 1 and 2 were elucidated by interpretation of spectroscopic data. Briareolate ester K (2 showed weak growth inhibition activity against human embryonic stem cells (BG02.

  11. Manejo do etileno em ameixas 'Laetitia' armazenadas sob atmosferas controlada e modificada ativa 'Laetitia' plums stored in controlled atmosphere and active modified atmosphere packing with ethylene management

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    Thais Roseli Corrêa

    2011-09-01

    Full Text Available O objetivo deste trabalho foi avaliar o efeito de condições de atmosfera controlada (AC e atmosfera modificada (AM ativa (filme PEBD de 40 µm, com duas perfurações de 1,0 mm de diâmetro, associadas ao manejo do etileno, sobre a manutenção da qualidade em ameixas 'Laetitia'. Os tratamentos avaliados consistiram no armazenamento refrigerado (60 dias a 0,5±0,1ºC em: atmosfera refrigerada (AR; 21,0 kPa O2 + The objective of this work was to evaluate the effect of controlled atmosphere (CA and active modified atmosphere packing (MAP [LDPE film (40 µm, with two perforations (diameter = 1.0 mm with ethylene management, on quality preservation of 'Laetitia' plums. The cold storage (60 days at 0.5±0.1ºC treatments evaluated were: stored atmosphere (SA; 21.0 kPa O2 + <0.03 kPa CO2; MAP; MAP + low ethylene (LE; CA; and CA + treatment with 1-MCP (1,0 µL L-1. The partial pressures of O2 + CO2 (kPa were 1.0 + 1.0and 2.5 + <0.1, in CA and MAP, respectively. Fruits stored in CA, regardless of ethylene removal, showed ripening delay compared to fruit in CS. However, the best preservation of flesh texture and titratable acidity was achieved in CA + 1-MCP. The incidences of decay, skin cracking and flesh browning were not different between treatments. Fruits stored in MAP + LE and CA + 1-MCP had lower of internal darkening and higher acceptability for color and taste compared to fruit stored in SA.

  12. Evaluation of Stress Scores Throughout Radiological Biopsies

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    Turkoglu

    2016-06-01

    with neck biopsy had the highest anxiety score. Conclusion We believe that active briefing of patients who need to undergo neck and bone biopsies and have high anxiety score by healthcare personnel is an effective method to control psychological mood and increase the efficiency of treatment.

  13. Atendimento ambulatorial individualizado versus programa de educação em grupo: qual oferece mais mudança de hábitos alimentares e de atividade física em crianças obesas? Individual outpatient care versus group education programs: which leads to greater change in dietary and physical activity habits for obese children?

    Directory of Open Access Journals (Sweden)

    Elza D. de Mello

    2004-12-01

    Full Text Available OBJETIVO: Comparar duas estratégias de manejo da obesidade infantil: atendimento ambulatorial (individual e programa de educação (em grupo. MÉTODO: Foram recrutados aleatoriamente crianças e adolescentes de 7 a 13 anos de idade, divididos em dois grupos: atendimento individual e atendimento em grupo. Foi criado um programa de educação em obesidade infantil, com encontros mensais que consistiam em aulas expositivas com a participação dos pais e trabalhos em grupos. Simultaneamente, o outro grupo era acompanhado individualmente em ambulatório. O acompanhamento ocorreu por 6 meses, sendo avaliados composição corporal, hábitos alimentares e atividade física, antes e depois das intervenções. RESULTADOS: A amostra foi constituída por 38 crianças e adolescentes com média de idade de 9,9 anos. O programa foi mais efetivo no aumento da atividade física (p = 0,003, especialmente caminhadas (p = 0,003, e na redução do colesterol total (p = 0,038. A redução do índice de massa corporal, do índice de obesidade e do consumo energético foi semelhante para os dois grupos. Quanto aos hábitos alimentares, o grupo acompanhado em ambulatório aumentou o consumo de frutas (p = 0,033 e hortaliças (p = 0,002 e reduziu o de salgadinho e batata frita (p = 0,041, enquanto o grupo que participou do programa reduziu o consumo de refrigerantes (p = 0,022, sanduíches, pizza e fast food (p = 0,006. CONCLUSÕES: Ambas as estratégias de manejo da obesidade infantil foram favoráveis a mudanças de hábitos alimentares e de atividade física. O atendimento em grupo, em um programa de educação em nutrição e saúde, foi tão ou mais efetivo que o atendimento individualizado em um ambulatório de referência, firmando-se como alternativa de tratamento à obesidade.OBJECTIVE: To compare two strategies for childhood obesity management: ambulatory assistance (individual and educational program (in group. METHOD: Children and adolescents from 7 to 13

  14. EMS provider determinations of necessity for transport and reimbursement for EMS response, medical care, and transport: combined resource document for the National Association of EMS Physicians position statements.

    Science.gov (United States)

    Millin, Michael G; Brown, Lawrence H; Schwartz, Brian

    2011-01-01

    With increasing demands for emergency medical services (EMS), many EMS jurisdictions are utilizing EMS provider-initiated nontransport policies as a method to offload potentially nonemergent patients from the EMS system. EMS provider determination of medical necessity, resulting in nontransport of patients, has the potential to avert unnecessary emergency department visits. However, EMS systems that utilize these policies must have additional education for the providers, a quality improvement process, and active physician oversight. In addition, EMS provider determination of nontransport for a specific situation should be supported by evidence in the peer-reviewed literature that the practice is safe. Further, EMS systems that do not utilize these programs should not be financially penalized. Payment for EMS services should be based on the prudent layperson standard. EMS systems that do utilize nontransport policies should be appropriately reimbursed, as this represents potential cost savings to the health care system.

  15. Endoscopic scoring systems for inflammatory bowel disease: pros and cons.

    Science.gov (United States)

    Tontini, Gian Eugenio; Bisschops, Raf; Neumann, Helmut

    2014-07-01

    Endoscopy plays a pivotal role for diagnosis and assessment of disease activity and extent in patients with inflammatory bowel diseases. International guidelines recommend the use of endoscopic scoring systems for evaluation of the prognosis and efficacy of medical treatments. Ideal scoring systems are easy to use, reproducible, reliable, responsive to changes, and validated in different clinical settings in order to guide therapeutic strategies. However, currently available endoscopic scoring systems often appear as complex for routine endoscopy and suffer from insufficient interobserver agreement and lack of formal validation which often limit their use in clinical trials. Here, we describe the role of endoscopic scoring systems in inflammatory bowel diseases focusing on pros and cons in the era of advanced endoscopic imaging and mucosal healing.

  16. Adaptação transcultral e qualidades psicométricas do recordatório de três dias de atividade física (three day physical activity recall) em escolares de 10 a 12 anos

    OpenAIRE

    Vinicius de Oliveira Damasceno

    2013-01-01

    Introdução: A utilização de questionários para mensurar o nível de atividade física e dispêndio energético diário (DED) em crianças e adolescentes é de fácil aplicação e baixo custo em estudos populacionais. Entretanto, a maioria dos instrumentos utilizados no Brasil não possuem adaptação transcultural, e portanto, não tiveram suas qualidades psicométricas testadas para a população alvo. Objetivo: Adaptadar, validar e testar a reprodutibilidade do Three Day Physical Activity Recall (3DPAR) em...

  17. Reference Gene Selection in the Desert Plant <em>Eremosparton songoricuem>m>

    Directory of Open Access Journals (Sweden)

    Dao-Yuan Zhang

    2012-06-01

    Full Text Available <em>Eremosparton songoricum em>(Litv. Vass. (<em>E. songoricumem> is a rare and extremely drought-tolerant desert plant that holds promise as a model organism for the identification of genes associated with water deficit stress. Here, we cloned and evaluated the expression of eight candidate reference genes using quantitative real-time reverse transcriptase polymerase chain reactions. The expression of these candidate reference genes was analyzed in a diverse set of 20 samples including various <em>E. songoricumem> plant tissues exposed to multiple environmental stresses. GeNorm analysis indicated that expression stability varied between the reference genes in the different experimental conditions, but the two most stable reference genes were sufficient for normalization in most conditions.<em> EsEFem> and <em>Esα-TUB> were sufficient for various stress conditions, <em>EsEF> and <em>EsACT> were suitable for samples of differing germination stages, and <em>EsGAPDH>and <em>Es>UBQ em>were most stable across multiple adult tissue samples. The <em>Es18Sem> gene was unsuitable as a reference gene in our analysis. In addition, the expression level of the drought-stress related transcription factor <em>EsDREB2em>> em>verified the utility of<em> E. songoricumem> reference genes and indicated that no single gene was adequate for normalization on its own. This is the first systematic report on the selection of reference genes in <em>E. songoricumem>, and these data will facilitate future work on gene expression in this species.

  18. An ultrasound score for knee osteoarthritis

    DEFF Research Database (Denmark)

    Riecke, B F; Christensen, R.; Torp-Pedersen, S

    2014-01-01

    OBJECTIVE: To develop standardized musculoskeletal ultrasound (MUS) procedures and scoring for detecting knee osteoarthritis (OA) and test the MUS score's ability to discern various degrees of knee OA, in comparison with plain radiography and the 'Knee injury and Osteoarthritis Outcome Score' (KOOS...

  19. Developing Score Reports for Cognitive Diagnostic Assessments

    Science.gov (United States)

    Roberts, Mary Roduta; Gierl, Mark J.

    2010-01-01

    This paper presents a framework to provide a structured approach for developing score reports for cognitive diagnostic assessments ("CDAs"). Guidelines for reporting and presenting diagnostic scores are based on a review of current educational test score reporting practices and literature from the area of information design. A sample diagnostic…

  20. Semiparametric score sevel susion: Gaussian sopula approach

    NARCIS (Netherlands)

    Susyanyo, N.; Klaassen, C.A.J.; Veldhuis, R.N.J.; Spreeuwers, L.J.

    2015-01-01

    Score level fusion is an appealing method for combining multi-algorithms, multi- representations, and multi-modality biometrics due to its simplicity. Often, scores are assumed to be independent, but even for dependent scores, accord- ing to the Neyman-Pearson lemma, the likelihood ratio is the opti

  1. Credit Scores, Race, and Residential Sorting

    Science.gov (United States)

    Nelson, Ashlyn Aiko

    2010-01-01

    Credit scores have a profound impact on home purchasing power and mortgage pricing, yet little is known about how credit scores influence households' residential location decisions. This study estimates the effects of credit scores on residential sorting behavior using a novel mortgage industry data set combining household demographic, credit, and…

  2. Breaking of scored tablets : a review

    NARCIS (Netherlands)

    van Santen, E; Barends, D M; Frijlink, H W

    2002-01-01

    The literature was reviewed regarding advantages, problems and performance indicators of score lines. Scored tablets provide dose flexibility, ease of swallowing and may reduce the costs of medication. However, many patients are confronted with scored tablets that are broken unequally and with diffi

  3. Auto-rotação cefálica ativa em pacientes com tontura/ vertigem Active cephalic auto-rotation in patients with dizziness/ vertigo

    Directory of Open Access Journals (Sweden)

    Aída R.M. de Assunção

    Full Text Available Introdução: A auto-rotação cefálica ativa é um teste rápido, de simples realização, não invasivo, que não causa desconforto ao paciente, pode ser realizado com facilidade em crianças e avalia o reflexo vestíbulo-ocular nas freqüências fisiológicas de movimentação da cabeça, utilizadas na vida cotidiana (de 1 a 4 Hz. Forma de estudo: clínico retrospectivo não randomizado. Objetivo: Avaliar pacientes com queixas de tontura/vertigem através da auto-rotação cefálica ativa comparando os sintomas com as alterações encontradas. Material e método: Um grupo de 1281 pacientes com queixa de tontura/vertigem foi submetido ao teste de auto-rotação cefálica ativa horizontal com alvo fixo, como uma etapa da avaliação otoneurológica. Resultados: As idades variaram de três a 93 anos com média de 49,6 anos, sendo 946 (73,8% do sexo feminino e 335 (26,2% do sexo masculino. A queixa de vertigem foi relatada por 896 (69,9% dos pacientes e a tontura por 385 (30,1%. A faixa de freqüência de resposta à prova de auto-rotação cefálica variou de 1,5 a 7,5Hz com média de 3,5Hz. A prova de auto-rotação cefálica ativa foi normal em 937 (73,1% e alterada em 344 (26,9% dos pacientes. As alterações mais freqüentes foram as relacionadas ao ganho (aumento, redução isoladas ou associadas a alterações de fase e simetria, em 241 (19% pacientes. O aumento do ganho isolado foi verificado em 92 pacientes (7,2%. Conclusão: Não houve relação entre as alterações na prova de auto-rotação cefálica ativa horizontal e as queixas de tontura e vertigem.Introduction: Active cephalic auto-rotation is a rapid, easy, painless and comfort test, that can be done in children and evaluate the vestibulo-ocular reflex in the physiologic frequencies of head, used in the every day life (from one to four hertz. Study design: clinical retrospective not randomized. Aim: Evaluate patients with complaints of dizziness/vertigo through the active

  4. Comparative Antioxidant Activity of Water Extract of ,em>Azadiractha indica Stem Bark and Telfairia occidentalis Leaf

    OpenAIRE

    C.P. Anokwuru; O. Ajibaye; A. Adesuyi

    2011-01-01

    The antioxidant activity of Azadirachta indica stem bark and Telfairia occidentalis leaf aqueous extract was studied. The Total Phenolic Content (TPC) was determined using folin Ciocalteu method while the Total Flavonoid Content (TFC) was determined using aluminum chloride method. Antioxidant activity was determined using 2, 2-diphenyl-1-picryl hydrazine (DPPH) inhibition. Telfairia occidentalis extracted more phenols (11.32g GAE/ 100g) than Azadirachta indica stem bark (10.74g GAE/100g) but ...

  5. <em>Ipomoea aquaticaem> Extract Shows Protective Action Against Thioacetamide-Induced Hepatotoxicity

    Directory of Open Access Journals (Sweden)

    A. Hamid A. Hadi

    2012-05-01

    Full Text Available In the Indian system of traditional medicine (Ayurveda it is recommended to consume <em>Ipomoea em>aquatica> to mitigate disorders like jaundice. In this study, the protective effects of ethanol extract of <em>I. aquaticaem> against liver damage were evaluated in thioacetamide (TAA-induced chronic hepatotoxicity in rats. There was no sign of toxicity in the acute toxicity study, in which Sprague-Dawley (SD rats were orally fed with <em>I. aquaticaem> (250 and 500 mg/kg for two months along with administration of TAA (i.p injection 200 mg/kg three times a week for two months. The results showed that the treatment of <em>I. aquaticaem> significantly lowered the TAA-induced serum levels of hepatic enzyme markers (ALP, ALT, AST, protein, albumin, bilirubin and prothrombin time. The hepatic content of activities and expressions SOD and CAT that were reduced by TAA were brought back to control levels by the plant extract supplement. Meanwhile, the rise in MDA level in the TAA receiving groups also were significantly reduced by <em>I. aquaticaem> treatment. Histopathology of hepatic tissues by H&E and Masson trichrome stains displayed that <em>I. aquaticaem> has reduced the incidence of liver lesions, including hepatic cells cloudy swelling, infiltration, hepatic necrosis, and fibrous connective tissue proliferation induced by TAA in rats. Therefore, the results of this study show that the protective effect of <em>I. aquaticaem> in TAA-induced liver damage might be contributed to its modulation on detoxification enzymes and its antioxidant and free radical scavenger effects. Moreover, it confirms a scientific basis for the traditional use of <em>I. aquaticaem> for the treatment of liver disorders.

  6. Test–retest reliability of the Disease Activity Score 28 CRP (DAS28-CRP), the Simplified Disease Activity Index (SDAI) and the Clinical Disease Activity Index (CDAI) in rheumatoid arthritis when based on patient self-assessment of tender and swollen joints

    DEFF Research Database (Denmark)

    Heegaard, Cecilie; Dreyer, Lene; Egsmose, Charlotte

    2013-01-01

    and physician-derived scores. Thirty out-clinic RA patients with stable disease were included. A joint count was performed two times 1 week apart by the patient and by an experienced physician. Test-retest reliability was expressed as the least significant difference (LSD), as the LSD in percent of the mean...... score (%LSD) and as intra-individual coefficients of variation (CVi). Mean scores based on physician vs. patient joint counts (visit 1) were: DAS28-CRP(4v) 3.5 ± 1.0 vs. 3.6 ± 1.1 (not significant (NS)), DAS28-CRP(3v) 3.4 ± 0.9 vs. 3.5 ± 0.9 (NS), SDAI 14.2 ± 9.4 vs.14.1 ± 9.4 (NS) and CDAI 13.4 ± 9.......3 vs. 13.3 ± 9.4 (NS). The LSDs (%LSD) for duplicate assessments of patient-derived scores (visit 2 vs. 1) were: DAS28-CRP(4v) 0.8 (23.2), DAS28-CRP(3v) 0.9 (25.2), SDAI 8.3 (59.9) and CDAI 8.4 (63.8). Similar LSDs were found for differences between duplicate assessments of physician-derived scores...

  7. O PAPEL DA MEDIAÇÃO E DA INTENCIONALIDADE EM ATIVIDADES DE MODELAGEM MATEMÁTICA. THE ROLE OF MEDIATION AND INTENTIONALITY IN MATHEMATICAL MODELLING ACTIVITIES

    Directory of Open Access Journals (Sweden)

    Vertuan, Rodolfo Eduardo

    2013-12-01

    Full Text Available Com o propósito de voltar a atenção ao processo de aprendizagem dos alunos quando envolvidos em atividades de Modelagem Matemática, este texto busca associar aspectos teóricos da Mediação Semiótica, do ponto de vista de Vygotsky, bem como da Intencionalidade como atributo para a aprendizagem. A atividade de Modelagem que analisamos é oriunda de um trabalho de pesquisa desenvolvida com alunos durante um curso de extensão e será analisada tomando elementos dos referenciais teóricos mencionados, a partir de registros escritos dos alunos e de transcrições de diálogos ocorridos durante o desenvolvimento da atividade. Considerando um ambiente de sala de aula com atividades de Modelagem, inferimos que, a mediação leva à intencionalidade e a intencionalidade leva a mediação e é por meio da “interação” desses dois elementos que a internalização de conceitos se torna possível, favorecendo a aprendizagem. In order to pay attention to the process of learning, when involved in mathematical modelling activities, this text seeks to associate the theoretical aspects of Semiotic Mediation, from the standpoint of Vygotsky, and Intentionality as an attribute to learning. The modelling activity present in the text is derived from a research conducted with students during a course of extension, which will be analyzed by taking elements of the theoretical frameworks mentioned from students' written records and transcripts of conversations that occurred during the activity development. Taking into consideration a classroom environment with modelling activities, we infer that the mediation leads to intentionality and intentionality leads to mediation and it is through the "interaction" of these two elements that the internalization of concepts becomes possible, encouraging learning.

  8. Committee Opinion No. 644: The Apgar Score.

    Science.gov (United States)

    2015-10-01

    The Apgar score provides an accepted and convenient method for reporting the status of the newborn infant immediately after birth and the response to resuscitation if needed. The Apgar score alone cannot be considered to be evidence of or a consequence of asphyxia, does not predict individual neonatal mortality or neurologic outcome, and should not be used for that purpose. An Apgar score assigned during a resuscitation is not equivalent to a score assigned to a spontaneously breathing infant. The American Academy of Pediatrics and the American College of Obstetricians and Gynecologists encourage use of an expanded Apgar score reporting form that accounts for concurrent resuscitative interventions.

  9. Comparative Antioxidant Activity of Water Extract of ,em>Azadiractha indica Stem Bark and Telfairia occidentalis Leaf

    Directory of Open Access Journals (Sweden)

    C.P. Anokwuru

    2011-07-01

    Full Text Available The antioxidant activity of Azadirachta indica stem bark and Telfairia occidentalis leaf aqueous extract was studied. The Total Phenolic Content (TPC was determined using folin Ciocalteu method while the Total Flavonoid Content (TFC was determined using aluminum chloride method. Antioxidant activity was determined using 2, 2-diphenyl-1-picryl hydrazine (DPPH inhibition. Telfairia occidentalis extracted more phenols (11.32g GAE/ 100g than Azadirachta indica stem bark (10.74g GAE/100g but not significantly different (p<0.05. Azadirachta indica stem bark extracted more flavonoid content (5.21g QE/100g than Telfairia occidentalis leaf (0.96g QE/100g. Azadirachta indica stem bark inhibited more free radicals (83% than Telfairia occidentalis leaf (65%. This study showed that Azadirachta indica stem bark had higher antioxidant activity compared to Telfairia occidentalis leaf.

  10. Thermodynamic analysis of hydrates formation in drilling activities; Analise termodinamica da formacao de hidratos em atividades de perfuracao

    Energy Technology Data Exchange (ETDEWEB)

    Baptista, Joao Marcelo Mussi; Rossi, Luciano Fernando dos Santos; Morales, Rigoberto E.M. [Universidade Tecnologica Federal do Parana (UTFPR), Curitiba, PR (Brazil)], e-mail: joaommussi@yahoo.com.br, e-mail: lfrossi@cefetpr.br, e-mail: rmorales@cefetpr.br

    2006-07-01

    The present work has for objective to present an analysis of hydrates formation in drilling activities. This analysis presents a study of the state conditions for gas hydrates formation in inhibitors containing systems (salts and alcohols, separately). To describe the nonidealities of liquid phase in electrolytic solutions, the activity coefficient model of Debye-Hueckel is used, as [4], and to describe the influence of alcohols in the activity of water, the UNQUAC model is used, as Parrish and Prausnitz. The hydrate phase is described by thermodynamic statistic model of van der Waals and Platteeuw, and the gaseous phase fugacities are modeled by the Peng-Robinson Equation of State. Some results are presented for saline inhibitors, and for methanol and ethyleneglycol. (author)

  11. Comparação do risco de queda em idosos sedentários e ativos por meio da escala de equilíbrio de Berg Comparison of fall risk between sedentary and active aged by means of the Berg balance scale

    Directory of Open Access Journals (Sweden)

    Renata Martins Pimentel

    2009-03-01

    Full Text Available O envelhecimento da população é um fenômeno mundial, do qual o Brasil apresenta um dos mais agudos processos. A prática regular de exercícios por idosos pode melhorar a capacidade física, proporcionar ganho de auto-estima e confiança, contribuindo para diminuição do risco de quedas, comuns em idosos. Este estudo visou comparar o risco de quedas entre idosos sedentários e ativos, verificando como a prática de exercício físico se reflete no desempenho dos sujeitos na escala de Berg. Foram avaliados por esse instrumento 70 idosos, divididos em 2 grupos: sedentários (n=35 e ativos (n=35. Os escores médios na escala de Berg dos grupos sedentário e ativo foram 47,7±5,6 pontos e 53,6±3,7, respectivamente (pPopulation aging is a worldwide phenomenon which is particularly acute in Brazil. Regular physical exercise by the aged may improve physical capacity, provide gains in self-esteem and confidence, and contribute to reducing the number of falls, which are common among the elderly. This study aimed at comparing fall risk between sedentary and active elderly subjects, by assessing how the regular practice of physical exercises is reflected by subjects' performance at the Berg balance scale. Seventy elderly subjects were divided into 2 groups, sedentary (n=35 and active (n=35, and submitted to the Berg test. The sedentary group mean score at the Berg scale was 47.7±5.6, and the active groups', 53.6±3.7 (p<0.0001. The odds ratio analysis showed that fall risk was 15.6 times higher for the sedentary group as compared to the active group (p=0.002. Since the performance of the sedentary group at the Berg scale was worse than the active group's, it may be said that regular practice of physical activities affects such performance, and that physically active subjects present less fall risk than sedentary ones.

  12. Use of remazol blue dyed avicel for the determination of cellulolytic activity in basidiomycetes Uso de Avicel colorida com Remazol Blue para determinação da atividade celulolítica em Basidiomycetos

    Directory of Open Access Journals (Sweden)

    Marcos José Correia

    1998-10-01

    Full Text Available A modified method for direct determination of cellulolytic activity using Avicel colored with Remazol Brilliant Blue R (RBBR in Agar test tubes is discussed. Refinements were introduced in a simple method for quantitation of cellulase activity, based on the release of dye from Avicel-RBBR medium by the enzymatic hydrolysis. Modifications in Avicel-dye preparation were enhanced and a spectrophotometer for direct OD measurement in agar test tubes used. The use of a spectrophotometer improved the precision of the collected data, since absorbance measurements could be done at the maximum wavelenght for RBBR (595 nm.Neste trabalho, é discutido um método modificado para determinação da atividade celulolítica em fungos utilizando Avicel colorida com Remazol Brilliant Blue R (RBBR, diretamente em tubos com ágar, a partir de refinamentos introduzidos em uma metodologia simples e baseada na liberação deste corante pela ação hidrolítica em Avicel colorida com o RBBR. Foram feitas modificações no preparo da Avicel colorida, bem como um espectrofotômetro para medição direta da absorbância nos tubos com ágar foi usado. O uso de espectrofotômetro aumentou a precisão dos dados coletados, pois permitiu leituras de absorbância no comprimento de onda máximo para RBBR (595 nm.

  13. <em>Helicobacter pyloriem> Disrupts Host Cell Membranes, Initiating a Repair Response and Cell Proliferation

    Directory of Open Access Journals (Sweden)

    Hsueh-Fen Juan

    2012-08-01

    Full Text Available <em>Helicobacter pyloriem> (<em>H. pyloriem>, the human stomach pathogen, lives on the inner surface of the stomach and causes chronic gastritis, peptic ulcer, and gastric cancer. Plasma membrane repair response is a matter of life and death for human cells against physical and biological damage. We here test the hypothesis that <em>H. pyloriem> also causes plasma membrane disruption injury, and that not only a membrane repair response but also a cell proliferation response are thereby activated. Vacuolating cytotoxin A (VacA and cytotoxin-associated gene A (CagA have been considered to be major <em>H. pyloriem> virulence factors. Gastric cancer cells were infected with <em>H. pyloriem> wild type (vacA+/cagA+, single mutant (ΔvacA or ΔcagA or double mutant (ΔvacA/ΔcagA strains and plasma membrane disruption events and consequent activation of membrane repair components monitored. <em>H. pyloriem> disrupts the host cell plasma membrane, allowing localized dye and extracellular Ca2+ influx. Ca2+-triggered members of the annexin family, A1 and A4, translocate, in response to injury, to the plasma membrane, and cell surface expression of an exocytotic maker of repair, LAMP-2, increases. Additional forms of plasma membrane disruption, unrelated to <em>H.> pylori em>exposure, also promote host cell proliferation. We propose that <em>H. pyloriem> activation of a plasma membrane repair is pro-proliferative. This study might therefore provide new insight into potential mechanisms of <em>H. pyloriem>-induced gastric carcinogenesis.

  14. Atividade microbiana em um Latossolo degradado tratado com lodo de esgoto Microbial activity in a degraded Latosol treated with sewage sludge

    Directory of Open Access Journals (Sweden)

    Gilberto Colodro

    2007-04-01

    Full Text Available Em geral, os solos degradados se apresentam com fraca atividade biológica, tendo em vista suas características físicas, baixa fertilidade e teores de matéria orgânica, devido principalmente à remoção ou degradação de sua camada superficial. O elevado teor de matéria orgânica facilmente decomposta do lodo de esgoto, que é uma fonte alternativa de resíduos orgânicos, aliado à sua elevada taxa dos principais elementos nutrientes às plantas, pode ser um fator importante do retorno ou incremento da atividade biológica dos solos degradados. Com a finalidade de se estudar as ações do lodo de esgoto na recuperação de um Latossolo degradado, utilizaram-se, como indicadores dos efeitos, o carbono na biomassa microbiana (Cmic, o carbono do CO2 (C-CO2 liberado e a relação entre o carbono microbiano e o carbono orgânico (Cmic/Corg; para isto, foram definidas duas doses de lodo de esgoto aplicadas em cobertura e incorporada, de 30 e 60 Mg ha-1 à base seca, juntamente com um tratamento com fertilizante mineral, utilizando-se o eucalipto como cultura teste. O delineamento experimental foi o inteiramente casualizado, com 4 tratamentos e 4 repetições. O lodo de esgoto promove aumento do C-CO2 liberado e do Cmic, os quais constituem indicativos de qualidade adequados ao monitoramento da recuperação do solo.The degraded soil shows, in general, poor biological activity, considering its physical characteristics, low fertility and organic matter, mainly due to removal or degradation of its superficial layer. The sewage sludge, due to its high content of easily decomposed organic matter can be an alternate source of organic residues and combined to its high content of the principal nutrients for the plants can be an important factor to promote biological activities in degraded soil. In order to study the actions of the sewage sludge in the recovery of a degraded Latosol, the carbon in the microbial biomass (Cmic, the carbon released CO2 (C

  15. Synthesis, Crystal Structure and Luminescent Property of Cd (II Complex with <em>N-Benzenesulphonyl-L>-leucine

    Directory of Open Access Journals (Sweden)

    Xishi Tai

    2012-09-01

    Full Text Available A new trinuclear Cd (II complex [Cd3(L6(2,2-bipyridine3] [L =<em> Nem>-phenylsulfonyl-L>-leucinato] has been synthesized and characterized by elemental analysis, IR and X-ray single crystal diffraction analysis. The results show that the complex belongs to the orthorhombic, space group<em> Pem>212121 with<em> aem> = 16.877(3 Å, <em>b> em>= 22.875(5 Å, <em>c em>= 29.495(6 Å, <em>α> em>= <emem>= <emem>= 90°, <em>V> em>= 11387(4 Å3, <em>Z> em>= 4, <em>Dc>= 1.416 μg·m−3, <emem>= 0.737 mm−1, <em>F> em>(000 = 4992, and final <em>R>1 = 0.0390, <em>ωR>2 = 0.0989. The complex comprises two seven-coordinated Cd (II atoms, with a N2O5 distorted pengonal bipyramidal coordination environment and a six-coordinated Cd (II atom, with a N2O4 distorted octahedral coordination environment. The molecules form one dimensional chain structure by the interaction of bridged carboxylato groups, hydrogen bonds and p-p interaction of 2,2-bipyridine. The luminescent properties of the Cd (II complex and <em>N-Benzenesulphonyl-L>-leucine in solid and in CH3OH solution also have been investigated.

  16. The Mystery of the Z-Score.

    Science.gov (United States)

    Curtis, Alexander E; Smith, Tanya A; Ziganshin, Bulat A; Elefteriades, John A

    2016-08-01

    Reliable methods for measuring the thoracic aorta are critical for determining treatment strategies in aneurysmal disease. Z-scores are a pragmatic alternative to raw diameter sizes commonly used in adult medicine. They are particularly valuable in the pediatric population, who undergo rapid changes in physical development. The advantage of the Z-score is its inclusion of body surface area (BSA) in determining whether an aorta is within normal size limits. Therefore, Z-scores allow us to determine whether true pathology exists, which can be challenging in growing children. In addition, Z-scores allow for thoughtful interpretation of aortic size in different genders, ethnicities, and geographical regions. Despite the advantages of using Z-scores, there are limitations. These include intra- and inter-observer bias, measurement error, and variations between alternative Z-score nomograms and BSA equations. Furthermore, it is unclear how Z-scores change in the normal population over time, which is essential when interpreting serial values. Guidelines for measuring aortic parameters have been developed by the American Society of Echocardiography Pediatric and Congenital Heart Disease Council, which may reduce measurement bias when calculating Z-scores for the aortic root. In addition, web-based Z-score calculators have been developed to aid in efficient Z-score calculations. Despite these advances, clinicians must be mindful of the limitations of Z-scores, especially when used to demonstrate beneficial treatment effect. This review looks to unravel the mystery of the Z-score, with a focus on the thoracic aorta. Here, we will discuss how Z-scores are calculated and the limitations of their use.

  17. Protease activated receptors (PARS) mediation in gyroxin biological activity; Mediacao dos receptores ativados por proteases (PARs) em atividades biologicas da giroxina

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Jose Alberto Alves da

    2009-07-01

    Gyroxin is a serine protease enzyme from the South American rattlesnake (Crotalus durissus terrificus) venom; it is only partially characterized and has multiple activities. Gyroxin induces blood coagulation, blood pressure decrease and a neurotoxic behavior named barrel rotation. The mechanisms involved in this neurotoxic activity are not known. Whereas gyroxin is a member of enzymes with high potential to become a new drug with clinical applications such as thrombin, batroxobin, ancrod, tripsyn and kalicrein, it is important to find out how gyroxin works. The analysis on agarose gel electrophoresis and circular dichroism confirmed the molecules' integrity and purity. The gyroxin intravenous administration in mice proved its neurotoxicity (barrel rotation). In vivo studies employing intravital microscopy proved that gyroxin induces vasodilation with the participation of protease activated receptors (PARs), nitric oxide and Na+K+ATPase. The leukocytes' adherence and rolling counting indicated that gyroxin has no pro inflammatory activity. Gyroxin induced platelet aggregation, which was blocked by inhibitors of PAR1 and PAR4 receptors (SCH 79797 and tcY-NH{sub 2}, respectively). Finally, it was proved that the gyroxin temporarily alter the permeability of the blood brain barrier (BBB). Our study has shown that both the protease-activated receptors and nitric oxide are mediators involved in the biological activities of gyroxin. (author)

  18. The relationship between second-year medical students' OSCE scores and USMLE Step 1 scores.

    Science.gov (United States)

    Simon, Steven R; Volkan, Kevin; Hamann, Claus; Duffey, Carol; Fletcher, Suzanne W

    2002-09-01

    The relationship between objective structured clinical examinations (OSCEs) and standardized tests is not well known. We linked second-year medical students' physical diagnosis OSCE scores from 1998, 1999 and 2000 (n = 355) with demographic information, Medical College Admission Test (MCAT) scores, and United States Medical Licensing Examination (USMLE) Step 1 scores. The correlation coefficient for the total OSCE score with USMLE Step 1 score was 0.41 (p USMLE Step 1 score. OSCE station scores accounted for approximately 22% of the variability in USMLE Step 1 scores. A second-year OSCE in physical diagnosis is correlated with scores on the USMLE Step 1 exam, with skills that foreshadow the clinical clerkships most predictive of USMLE scores. This correlation suggests predictive validity of this OSCE and supports the use of OSCEs early in medical school.

  19. Random Walk Picture of Basketball Scoring

    CERN Document Server

    Gabel, Alan

    2011-01-01

    We present evidence, based on play-by-play data from all 6087 games from the 2006/07--2009/10 seasons of the National Basketball Association (NBA), that basketball scoring is well described by a weakly-biased continuous-time random walk. The time between successive scoring events follows an exponential distribution, with little memory between different scoring intervals. Using this random-walk picture that is augmented by features idiosyncratic to basketball, we account for a wide variety of statistical properties of scoring, such as the distribution of the score difference between opponents and the fraction of game time that one team is in the lead. By further including the heterogeneity of team strengths, we build a computational model that accounts for essentially all statistical features of game scoring data and season win/loss records of each team.

  20. Activity of fungal phytases stored in two ways in response to the period of storage at room temperature Atividade de fitases fúngicas armazenadas de duas maneiras em resposta ao período de armazenamento à temperatura ambiente

    Directory of Open Access Journals (Sweden)

    Luciana de Paula Naves

    2012-01-01

    Full Text Available Two distinct experiments were conducted simultaneously with phytases of Aspergillus oryzae and A. niger for determining enzyme activity in response to storage period (up to 180 days at room temperature - RT. In the first experiment, enzymes were stored as they were acquired (pure form and the activity was measured periodically during 180 days of storage at RT. In the second experiment, the phytases were incorporated to a supplement containing vitamins, minerals, and amino acids; and then this supplement was stored at RT up to 180 days, so that every 30 days of storage was collected one aliquot from each replicate for determining enzymatic activity. In conclusion, the phytase activity is affected by storage duration. To ensure 80% of the initial activity, the phytases of A. oryzae and A. niger can be stored in the pure forms for up to 53 and 135 days at RT, respectively. However, if the phytases of A. oryzae and A. niger are incorporated to a supplement containing vitamins, minerals, and amino acids then the storage period at RT should not exceed 67 and 77 days, respectively.Dois experimentos distintos foram realizados simultaneamente com fitases de Aspergillus oryzae e A. niger para a determinação da atividade enzimática em resposta ao período de armazenamento (por até 180 dias em temperatura ambiente - TA. No primeiro experimento, as enzimas foram armazenadas como adquiridas (forma pura e a atividade foi determinada periodicamente durante 180 dias de armazenamento em TA. No segundo experimento, as fitases foram incorporadas a um suplemento contendo vitaminas, minerais e aminoácidos. Então este suplemento foi armazenado em TA por até 180 dias, de modo que, a cada 30 dias de armazenamento, uma alíquota de cada repetição foi coletada para a determinação da atividade enzimática. Conclui-se que a atividade da fitase é afetada pela duração do armazenamento. Para assegurar 80% da atividade inicial, as fitases de A. oryzae e A. niger

  1. Determinação do teor de princípios ativos em matérias-primas vegetais Determination of active principles in vegetable raw materials

    Directory of Open Access Journals (Sweden)

    Maria Teresa F. Bara

    2006-06-01

    Full Text Available Castanha-da-índia (Aesculus hippocastanum L., hipérico (Hypericum perforatum L., guaraná (Paullinia cupana H.B.K. e ginkgo (Ginkgo biloba L. fazem parte de formulações de medicamentos fitoterápicos muito comercializados no Brasil. Neste trabalho foi avaliada a qualidade de amostras de pós e extratos destas plantas. Para a determinação do teor de princípios ativos foram aplicados métodos farmacopéicos ou citados na literatura científica e os resultados demonstraram serem adequados para a análise destes produtos farmacêuticos. Verificou-se que 60% das amostras analisadas de guaraná e ginkgo estavam em desacordo com as especificações farmacopéicas ou as declaradas pelos laudos dos fabricantes, em relação ao teor de princípios ativos. Além disso, 100% e 20%, respectivamente, das amostras de hipérico e de castanha-da-índia apresentaram teores abaixo das especificações. Os dados obtidos mostraram ser de grande importância e necessidade a implementação de técnicas quantitativas no controle de qualidade físico-químico de matérias-primas vegetais.Pharmaceutical preparations containing Aesculus hippocastanum L., Hypericum perforatum L., Paullinia cupana H.B.K. and Ginkgo biloba L. have large market. In this work the quality of the powder or extracts of these plants were evaluated. Pharmacopoeia methods or those cited on cientific literature for quantification of active substances were employed and the data showed them to be adequate for these analyses. The analytical results demonstrated that 60% of the samples of P. cupana and G. biloba, and 100% and 20%, respectively of samples of H. perforatum and A. hippocastanum were not in agreement with the specifications. This analysis showed to be valuable for herbal medicines quality control.

  2. <em>Cassia spectabilis em>(DC Irwin et Barn: A Promising Traditional Herb in Health Improvement

    Directory of Open Access Journals (Sweden)

    Subramanian Deivanai

    2012-08-01

    Full Text Available The genus <em>Cassia>, comprising about 600 species widely distributed worldwide is well known for its diverse biological and pharmacological properties. <em>Cassia spectabilis em>(sin <em>Senna spectabilisem> (DC Irwin et Barn (Fabaceae is widely grown as an ornamental plant in tropical and subtropical areas. <em>C. spectabilis em>has been commonly used in traditional medicine for many years. Information in the biomedical literature has indicated the presence of a variety of medicinally-important chemical constituents in <em>C. spectabilisem>. Pharmacological studies by various groups of investigators have shown that <em>C. spectabilisem> possesses significant biological activity, such as antibacterial, antibiofilm, antifungal and antioxidant properties. Beside this, toxicity studies of this plant have revealed no toxic effect on mice. In view of the immense medicinal importance of <em>C. spectabilisem>, this review aimed at compiling all currently available information on <em>C. spectabilisem>’s botany, phytochemistry, pharmacology, and mechanism of actions, toxicology and its ethnomedicinal uses.

  3. Correlation of the score for subjective pain with physical disability, clinical and radiographic scores in recent onset rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    Turiel Maurizio

    2002-07-01

    Full Text Available Abstract Background To analyse the relationship between subjective pain score and other measures of clinical, radiographic and functional status; in particular Larsen radiographic scores and Health Assessment Questionnaire (HAQ; in patients with severe rheumatoid arthritis (RA with a disease duration of less than 3 years. Methods In this cross sectional study of 105 patients with RA (76 women, 29 men: mean age 50.93; mean disease duration 15.86 months; 71% rheumatoid factor positive subjective pain was assessed according to the Visual Analog Scale (VAS. Correlation coefficients between pain score and disease activity measures (patients' global assessment of disease by VAS, number of tender and swollen joints, morning stiffness, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP] and titre of rheumatoid factor, radiographic evaluations (Larsen-Dale scores for radiographic damage of the small joints of the hands, wrist and feet, disability measures (health assessment questionnaire [HAQ], and demographic variables were calculated; hierarchical regression analysis was done with subjective pain score as the dependent variable. Results The Spearman's correlation coefficient comparing subjective pain and HAQ was 0.421 (p 0.05. In regression analysis, global assessment of disease by patients explained 32.8% of the variation in pain intensity score, morning stiffness 10.7%, CRP 4.0%, HAQ 3.8% and Larsen-Dale scores explained 2.1%; other variables were not significant in the model. Conclusions Pain scores of patients with early severe rheumatoid arthritis are correlated at higher levels with patients' global assessment of disease and with morning stiffness rather than with radiographic or other clinical variables such as number of tender and swollen joints.

  4. Comparison of Sports Sciences and Education Faculty Students' Aggression Scores

    Science.gov (United States)

    Atan, Tülin

    2016-01-01

    The aim of this study was to compare the aggression scores of Sports Sciences Faculty and Education Faculty students and also to examine the effects of some demographic variables on aggression. Two hundred Sports Sciences Faculty students (who engage in sporting activities four days a week for two hours) and 200 Education Faculty students (who do…

  5. [The cardiovascular surgeon and the Syntax score].

    Science.gov (United States)

    Gómez-Sánchez, Mario; Soulé-Egea, Mauricio; Herrera-Alarcón, Valentín; Barragán-García, Rodolfo

    2015-01-01

    The Syntax score has been established as a tool to determine the complexity of coronary artery disease and as a guide for decision-making among coronary artery bypass surgery and percutaneous coronary intervention. The purpose of this review is to systematically examine what the Syntax score is, and how the surgeon should integrate the information in the selection and treatment of patients. We reviewed the results of the SYNTAX Trial, the clinical practice guidelines, as well as the benefits and limitations of the score. Finally we discuss the future directions of the Syntax score.

  6. Security Risk Scoring Incorporating Computers' Environment

    Directory of Open Access Journals (Sweden)

    Eli Weintraub

    2016-04-01

    Full Text Available A framework of a Continuous Monitoring System (CMS is presented, having new improved capabilities. The system uses the actual real-time configuration of the system and environment characterized by a Configuration Management Data Base (CMDB which includes detailed information of organizational database contents, security and privacy specifications. The Common Vulnerability Scoring Systems' (CVSS algorithm produces risk scores incorporating information from the CMDB. By using the real updated environmental characteristics the system enables achieving accurate scores compared to existing practices. Framework presentation includes systems' design and an illustration of scoring computations.

  7. Pneumonia severity scores in resource poor settings

    Directory of Open Access Journals (Sweden)

    Jamie Rylance

    2014-06-01

    Full Text Available Clinical prognostic scores are increasingly used to streamline care in well-resourced settings. The potential benefits of identifying patients at risk of clinical deterioration and poor outcome, delivering appropriate higher level clinical care, and increasing efficiency are clear. In this focused review, we examine the use and applicability of severity scores applied to patients with community acquired pneumonia in resource poor settings. We challenge clinical researchers working in such systems to consider the generalisability of existing severity scores in their populations, and where performance of scores is suboptimal, to promote efforts to develop and validate new tools for the benefit of patients and healthcare systems.

  8. Use of active dosemeters as a optimization tool in hemodynamics; Uso de dosimetros ativos como ferramenta de otimizacao em hemodinamica

    Energy Technology Data Exchange (ETDEWEB)

    Nunes, Rafael; Pereira, Dirceu D. [Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ (Brazil). Inst. de Fisica; Canevaro, Lucia V. [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Rodrigues, Barbara B.D. [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil); Ferreira, Esmeralci [Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ (Brazil). Faculdade de Medicina. Servico de Hemodinamica

    2016-07-01

    Interventional cardiology procedures are, in general, associated with high doses in patients and professionals. The objective of this study is to measure the radiation levels received by professionals .The professional dosimetry was performed in a department of Hemodynamics of University Hospital in Rio de Janeiro. were followed 331 coronary angiography (CA) and 26 percutaneous transluminal coronary angioplasty (PTCA) procedures. For this, were used active dosemeters to measure the radiation levels at the chest of interventional professionals. The results show that average personal equivalent dose of doctors, per procedure was 100 e 154 μSv. On average, nursing technicians and radiologist receive 12 and 10% of doses of physicians, respectively, during CA procedures. From the results, it appears that the doses of hemodynamics exceed the annual dose limit of the standards. The use of lead shielding is presented as an effective action to reduce doses in these workers. (author)

  9. Application of consensus scoring and principal component analysis for virtual screening against β-secretase (BACE-1.

    Directory of Open Access Journals (Sweden)

    Shu Liu

    Full Text Available BACKGROUND: In order to identify novel chemical classes of β-secretase (BACE-1 inhibitors, an alternative scoring protocol, Principal Component Analysis (PCA, was proposed to summarize most of the information from the original scoring functions and re-rank the results from the virtual screening against BACE-1. METHOD: Given a training set (50 BACE-1 inhibitors and 9950 inactive diverse compounds, three rank-based virtual screening methods, individual scoring, conventional consensus scoring and PCA, were judged by the hit number in the top 1% of the ranked list. The docking poses were generated by Surflex, five scoring functions (Surflex_Score, D_Score, G_Score, ChemScore, and PMF_Score were used for pose extraction. For each pose group, twelve scoring functions (Surflex_Score, D_Score, G_Score, ChemScore, PMF_Score, LigScore1, LigScore2, PLP1, PLP2, jain, Ludi_1, and Ludi_2 were used for the pose rank. For a test set, 113,228 chemical compounds (Sigma-Aldrich® corporate chemical directory were docked by Surflex, then ranked by the same three ranking methods motioned above to select the potential active compounds for experimental test. RESULTS: For the training set, the PCA approach yielded consistently superior rankings compared to conventional consensus scoring and single scoring. For the test set, the top 20 compounds according to conventional consensus scoring were experimentally tested, no inhibitor was found. Then, we relied on PCA scoring protocol to test another different top 20 compounds and two low micromolar inhibitors (S450588 and 276065 were emerged through the BACE-1 fluorescence resonance energy transfer (FRET assay. CONCLUSION: The PCA method extends the conventional consensus scoring in a quantitative statistical manner and would appear to have considerable potential for chemical screening applications.

  10. Adaptação transcultural da Escala de Independência em Atividades da Vida Diária (Escala de Katz Cross-cultural adaptation of the Independence in Activities of Daily Living Index (Katz Index

    Directory of Open Access Journals (Sweden)

    Valéria Teresa Saraiva Lino

    2008-01-01

    Full Text Available Desenvolvimento e análise do desempenho de uma adaptação transcultural para o português da Escala de Katz de independência em atividades da vida diária. Duas traduções e duas retrotraduções analisaram as equivalências conceitual, de itens e semântica para a escolha da versão final. A equivalência operacional foi avaliada em um estudo piloto, testando-se a confiabilidade e a consistência interna da versão adaptada por meio de reteste no mesmo dia em 156 pacientes ou após sete dias da primeira entrevista. A resolução de diferenças sutis em alguns itens levou à equivalência cultural. A versão final foi considerada fácil de se entender e de aplicar. A concordância corrigida para o acaso (kappa ponderado foi de 0,91. O alfa de Chronbach variou de 0,80 a 0,92. A versão em português da Escala de Katz de independência em atividades da vida diária, completamente desenvolvida e testada, provou ser equivalente à original em inglês. Os itens apresentaram consistência interna e as taxa foram confiáveis.This study involved the development and performance assessment of a cultural adaptation of the Katz scale of independence in activities of daily living, translated into Portuguese in Brazil. Two translations and two back-translations of the items were analyzed by experts in order to decide on the final version. Operational equivalence was assessed in a pilot study. The reliability and internal consistency of the adapted version were assessed by retesting 156 patients on the same day or 7 days after the first interview. Cultural equivalence was achieved after resolving subtle differences in some items. The final version was considered easy to understand and use. Chance-corrected agreement (weighted kappa was 0.91. Cronbach's alpha ranged from 0.80 to 0.92. CONCLUSIONS: a Portuguese version of the Katz scale of independence in activities of daily living, thoroughly developed and tested, proved equivalent to the original version

  11. Bioremediation process in impacted area of petroleum activities; Processos de biorremediacao em areas influenciadas por atividades petroliferas

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Olivia Maria Cordeiro de; Trigueis, Jorge Alberto; Queiroz, Antonio Fernando de Souza; Celino, Joil Jose; Lima, Danusia Ferreira; Santana, Robson Carneiro [Universidade Federal da Bahia (UFBA), Salvador, BA (Brazil). Inst. de Geociencias

    2008-07-01

    The present work's objective is to test sampling methodologies applied on the bioremediation processes in situ, involving the establishment of sample replicates, specific laboratory procedures and its results, inedited on the referred technique. Agricultural fertilizers were used, NPK and OSMOCOTE, as biostimulants on mangroves substrates affected by petroleum activities. The tested methodology used on the experiment was based on the monitoring of this technology in aquarium with water from Sao Paulo's river and sediment contaminated by oil, realized in three steps (first pre-test, second pre-test and third pre-test) that happened between the months of August and November of 2007. The physical-chemical parameters were measured with portable devices carefully calibrated and the oil analyzed with gas chromatography. The saturated hydrocarbons (n-alkenes) had an increase on the concentrations for some aquariums and these found results do not permit to confirm if the inhibition of the degradation of the saturated hydrocarbons are somehow related to the usage of the nutrients NPK or OSMOCOTE. The time interval applied on the procedure, the sampling methodology used and even the intrinsic heterogeneity of the mangrove substrate are in the evaluation stage with new tests in order to make better the technique delineation, inedited, utilized in the area. (author)

  12. Widening clinical applications of the SYNTAX Score.

    Science.gov (United States)

    Farooq, Vasim; Head, Stuart J; Kappetein, Arie Pieter; Serruys, Patrick W

    2014-02-01

    The SYNTAX Score (http://www.syntaxscore.com) has established itself as an anatomical based tool for objectively determining the complexity of coronary artery disease and guiding decision-making between coronary artery bypass graft (CABG) surgery and percutaneous coronary intervention (PCI). Since the landmark SYNTAX (Synergy between PCI with Taxus and Cardiac Surgery) Trial comparing CABG with PCI in patients with complex coronary artery disease (unprotected left main or de novo three vessel disease), numerous validation studies have confirmed the clinical validity of the SYNTAX Score for identifying higher-risk subjects and aiding decision-making between CABG and PCI in a broad range of patient types. The SYNTAX Score is now advocated in both the European and US revascularisation guidelines for decision-making between CABG and PCI as part of a SYNTAX-pioneered heart team approach. Since establishment of the SYNTAX Score, widening clinical applications of this clinical tool have emerged. The purpose of this review is to systematically examine the widening applications of tools based on the SYNTAX Score: (1) by improving the diagnostic accuracy of the SYNTAX Score by adding a functional assessment of lesions; (2) through amalgamation of the anatomical SYNTAX Score with clinical variables to enhance decision-making between CABG and PCI, culminating in the development and validation of the SYNTAX Score II, in which objective and tailored decisions can be made for the individual patient; (3) through assessment of completeness of revascularisation using the residual and post-CABG SYNTAX Scores for PCI and CABG patients, respectively. Finally, the future direction of the SYNTAX Score is covered through discussion of the ongoing development of a non-invasive, functional SYNTAX Score and review of current and planned clinical trials.

  13. Desempenho e atividades enzimáticas em girinos de rã-touro Performance and enzymatic activities of the bullfrog tadpoles

    Directory of Open Access Journals (Sweden)

    José Teixeira de Seixas Filho

    2008-11-01

    Full Text Available O objetivo deste trabalho foi avaliar o desempenho e as atividades das enzimas digestivas de girinos de rã-touro, alimentados com ração comercial durante 60 dias, com um girino por litro, em caixas com 30 L de água. Os parâmetros medidos quinzenalmente foram: sobrevivência, comprimento, peso final, consumo de ração, e a atividade de amilase, lipase e tripsina. O maior crescimento dos girinos foi do 15º ao 45º dia - 20,61 mm. Durante os primeiros 15 dias, os girinos apresentaram a maior taxa de crescimento específico, 16,73% por dia. Do 45º ao 60º dia, os girinos apresentaram o maior ganho de peso, 3,98±0,73 g, o maior consumo de ração, 14,40±1,14 g, e a melhor conversão alimentar, 3,67:1,0±0,18. Houve aumento significativo da atividade enzimática depois do 30º dia. Observaram-se relações entre as atividades específicas das enzimas e os distintos estágios de desenvolvimento dos girinos.The objective of this study was to evaluate the performance and the digestive enzyme activity in bullfrog tadpoles, fed with commercial ration during 60 days, at the density of one tadpole per liter in 30 L boxes. The parameters measured fortnightly were: survival, length, weight, ration consumption, and amylase, lipase and trypsin activities. There larger growth of the tadpoles occurred from the 15th to the 45th day - 20.61 mm. During the first 15 days, the tadpoles had the largest specific growth rate, 16.7% per day. From the 45th to the 60th day, the tadpoles had the largest weight gain, 3.98±0.73 g, the largest ration consumption, 14.40±1.14 g and the best feed conversion, 3.67:1.0±0.18. There was significant increase in enzyme activities after the 30th day. Relationships were observed between the specific enzyme activities and the different development phases of the tadpoles.

  14. Extraction of Dihydroquercetin<em> em>from <em>Larix gmeliniem>i> em>with Ultrasound-Assisted and Microwave-Assisted Alternant Digestion

    Directory of Open Access Journals (Sweden)

    Yuangang Zu

    2012-07-01

    Full Text Available An ultrasound and microwave assisted alternant extraction method (UMAE was applied for extracting dihydroquercetin (DHQ from <em>Larix gmeliniem>i> wood. This investigation was conducted using 60% ethanol as solvent, 1:12 solid to liquid ratio, and 3 h soaking time. The optimum treatment time was ultrasound 40 min, microwave 20 min, respectively, and the extraction was performed once. Under the optimized conditions, satisfactory extraction yield of the target analyte was obtained. Relative to ultrasound-assisted or microwave-assisted method, the proposed approach provides higher extraction yield. The effect of DHQ of different concentrations and synthetic antioxidants on oxidative stability in soy bean oil stored for 20 days at different temperatures (25 °C and 60 °C was compared. DHQ was more effective in restraining soy bean oil oxidation, and a dose-response relationship was observed. The antioxidant activity of DHQ was a little stronger than that of BHA and BHT. Soy bean oil supplemented with 0.08 mg/g DHQ exhibited favorable antioxidant effects and is preferable for effectively avoiding oxidation. The <em>L. gmeliniiem> wood samples before and after extraction were characterized by scanning electron microscopy. The results showed that the UMAE method is a simple and efficient technique for sample preparation.

  15. POLIAMINAS E ATIVIDADE DA PEROXIDASE EM FEIJÃO (Phaseolus vulgaris L. CULTIVADO SOB ESTRESSE SALINO POLYAMINES AND PEROXIDASE ACTIVITY IN BEAN (Phaseolus vulgaris L. GROWN UNDER SALINE STRESS

    Directory of Open Access Journals (Sweden)

    Giuseppina Pace Pereira Lima

    1999-01-01

    Full Text Available O teor de poliaminas (putrescina, espermidina e espermina e a atividade enzimática da peroxidase (EC 1.11.1.7 foram determinados em plantas de Phaseolus vulgaris L. cv Carioquinha, após terem sido submetidas a estresse salino (50 e 100 mM de NaCl. Foram observadas alterações nos teores das poliaminas, principalmente putrescina, que aumentou com o tempo e a concentração de NaCl. Também ocorreu aumento na atividade da peroxidase em ambas concentrações de NaCl utilizadas. Os resultados mostraram alterações no metabolismo de poliaminas e peroxidases nas plantas de feijão cultivadas em meio salino.Putrescine, spermidine and spermine contents and peroxidase activity (EC 1.11.1.7 were determined in plants of Phaseolus vulgaris L. cv Carioquinha submitted to saline stress (50 and 100 mM NaCl. Changes were observed in polyamine contents, mainly in putrescine. Increase in peroxidase activity also occurred with NaCl concentration, for both concentrations used. The results showed alterations in the polyamines contents and peroxidase activity in plants of Phaseolus vulgaris grown under salinity.

  16. Bayesian Model Averaging for Propensity Score Analysis

    Science.gov (United States)

    Kaplan, David; Chen, Jianshen

    2013-01-01

    The purpose of this study is to explore Bayesian model averaging in the propensity score context. Previous research on Bayesian propensity score analysis does not take into account model uncertainty. In this regard, an internally consistent Bayesian framework for model building and estimation must also account for model uncertainty. The…

  17. Starreveld scoring method in diagnosing childhood constipation

    NARCIS (Netherlands)

    Kokke, F.T.; Sittig, J.S.; de Bruijn, A.; Wiersma, T.; van Rijn, R.R.; Limpen, J.L.; Houwen, R.H.; Fischer, K.; Benninga, M.A.

    2010-01-01

    Four scoring methods exist to assess severity of fecal loading on plain abdominal radiographs in constipated patients (Barr-, Starreveld-, Blethyn- and Leech). So far, the Starreveld score was used only in adult patients. To determine accuracy and intra- and inter-observer agreement of the Starrevel

  18. Causal Moderation Analysis Using Propensity Score Methods

    Science.gov (United States)

    Dong, Nianbo

    2012-01-01

    This paper is based on previous studies in applying propensity score methods to study multiple treatment variables to examine the causal moderator effect. The propensity score methods will be demonstrated in a case study to examine the causal moderator effect, where the moderators are categorical and continuous variables. Moderation analysis is an…

  19. ON HOW CULTURAL KNOWLEDGE AFFECTS TOEFL SCORES

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    This paper presents a study of the effect of cultur-al background on TOEFL scores.It proceeds from therelation between culture and language,then illus-trates with actual questions from various sections ofTOEFL tests how American cultural background exertsa remarkable influence on TOEFL scores,and con-cludes with revelations with regard to English teachingin this country.

  20. Clinical scoring scales in thyroidology: A compendium

    Directory of Open Access Journals (Sweden)

    Sanjay Kalra

    2011-01-01

    Full Text Available This compendium brings together traditional as well as contemporary scoring and grading systems used for the screening and diagnosis of various thyroid diseases, dysfunctions, and complications. The article discusses scores used to help diagnose hypo-and hyperthyroidism, to grade and manage goiter and ophthalmopathy, and to assess the risk of thyroid malignancy.

  1. On k-hypertournament losing scores

    CERN Document Server

    Pirzada, Shariefuddin

    2010-01-01

    We give a new and short proof of a theorem on k-hypertournament losing scores due to Zhou et al. [G. Zhou, T. Yao, K. Zhang, On score sequences of k-tournaments, European J. Comb., 21, 8 (2000) 993-1000.

  2. Artificial metaplasticity neural network applied to credit scoring.

    Science.gov (United States)

    Marcano-Cedeño, Alexis; Marin-de-la-Barcena, A; Jimenez-Trillo, J; Piñuela, J A; Andina, D

    2011-08-01

    The assessment of the risk of default on credit is important for financial institutions. Different Artificial Neural Networks (ANN) have been suggested to tackle the credit scoring problem, however, the obtained error rates are often high. In the search for the best ANN algorithm for credit scoring, this paper contributes with the application of an ANN Training Algorithm inspired by the neurons' biological property of metaplasticity. This algorithm is especially efficient when few patterns of a class are available, or when information inherent to low probability events is crucial for a successful application, as weight updating is overemphasized in the less frequent activations than in the more frequent ones. Two well-known and readily available such as: Australia and German data sets has been used to test the algorithm. The results obtained by AMMLP shown have been superior to state-of-the-art classification algorithms in credit scoring.

  3. A Bayesian Approach to Learning Scoring Systems.

    Science.gov (United States)

    Ertekin, Şeyda; Rudin, Cynthia

    2015-12-01

    We present a Bayesian method for building scoring systems, which are linear models with coefficients that have very few significant digits. Usually the construction of scoring systems involve manual effort-humans invent the full scoring system without using data, or they choose how logistic regression coefficients should be scaled and rounded to produce a scoring system. These kinds of heuristics lead to suboptimal solutions. Our approach is different in that humans need only specify the prior over what the coefficients should look like, and the scoring system is learned from data. For this approach, we provide a Metropolis-Hastings sampler that tends to pull the coefficient values toward their "natural scale." Empirically, the proposed method achieves a high degree of interpretability of the models while maintaining competitive generalization performances.

  4. Propensity score weighting with multilevel data.

    Science.gov (United States)

    Li, Fan; Zaslavsky, Alan M; Landrum, Mary Beth

    2013-08-30

    Propensity score methods are being increasingly used as a less parametric alternative to traditional regression to balance observed differences across groups in both descriptive and causal comparisons. Data collected in many disciplines often have analytically relevant multilevel or clustered structure. The propensity score, however, was developed and has been used primarily with unstructured data. We present and compare several propensity-score-weighted estimators for clustered data, including marginal, cluster-weighted, and doubly robust estimators. Using both analytical derivations and Monte Carlo simulations, we illustrate bias arising when the usual assumptions of propensity score analysis do not hold for multilevel data. We show that exploiting the multilevel structure, either parametrically or nonparametrically, in at least one stage of the propensity score analysis can greatly reduce these biases. We applied these methods to a study of racial disparities in breast cancer screening among beneficiaries of Medicare health plans.

  5. Emerald zoyzia grass development regarding photosynthetically active radiation in different slopes Desenvolvimento da grama-esmeralda em relação à radiação fotossinteticamente ativa em diferentes declividades

    Directory of Open Access Journals (Sweden)

    Ruchele M. Coan

    2012-06-01

    Full Text Available With this study, the objective was to estimate the photosynthetically active radiation (PAR and to correlate it with the dry matter (MMSPA of the emerald zoysia (Zoysia japonica Steud. on surfaces with different expositions and slopes. The research was conducted at the Experimental Watershed of the Agricultural Engineering Department, School of Agriculture and Veterinary Sciences of São Paulo State University (FCAV/UNESP, Brazil, where the surfaces (H, 10 N, 30 N, 50 N, 10 S, 30 S, 50 S, 10 L, 30 L, 50 L, 10 O, 30 O and 50 O were used. To obtain the global solar radiation, it was installed an automated weather station where the PAR (dependent variable was obtained by the equation y = a + bx, and the global radiation was independent. To compare means of MMSPA, it was used the Tukey test at 5% probability, and to assess the relation PAR/MMSPA, the simple linear correlation coefficient. The result showed that the accumulation of these effects in the PAR increases with North exposure and decreases with the South, and exposure to 50N is most suitable for slopes, not having correlation between the PAR and the MMSPA for the surfaces evaluated for the study period.Com este trabalho, o objetivo foi estimar a radiação fotossinteticamente ativa (PAR e correlacioná-la com a massa de matéria seca (MMSPA da grama-esmeralda (Zoysia japonica Steud., em superfícies com diferentes exposições e declividades. A pesquisa foi desenvolvida na Bacia Hidrográfica Experimental do Departamento de Engenharia Rural, FCAV/UNESP, Brasil, onde foram utilizadas as superfícies (H; 10 N; 30 N; 50 N; 10 S; 30 S; 50 S; 10 L; 30 L; 50 L; 10 O; 30 O e 50 O. Para a obtenção da radiação solar global, foi instalada uma estação meteorológica automatizada, onde a PAR (variável dependente foi obtida por meio da equação y = a + bx, e a radiação global foi a independente. Para comparação de médias da MMSPA, utilizou-se o teste de Tukey, a 5% de probabilidade, e para

  6. Synthesis and Cytotoxicity Evaluation of 13-<em>n>-Alkyl Berberine and Palmatine Analogues as Anticancer Agents

    Directory of Open Access Journals (Sweden)

    Lei Zhang

    2012-09-01

    Full Text Available By introducing long carbon-chain alkyl groups at the C-13 position of berberine and palmatine, 13-<em>n>-hexyl/13-<em>n>-octyl berberine and palmatine chloride analogues 4ad were synthesized and examined by MTT assays for cytotoxic activity in seven human cancer cell lines (7701QGY, SMMC7721, HepG2, CEM, CEM/VCR, KIII, Lewis, yielding IC50 values of 0.02 ± 0.01–13.58 ± 2.84 μM. 13-<em>n>-Octyl palmatine (compound 4d gave the most potent inhibitor activity, with an IC50 of 0.02 ± 0.01 μM for SMMC7721. In all cases, the 13-<em>n>-alkyl berberine and palmatine analogues 4ad were more cytotoxic than berberine and palmatine. In addition, compounds 4ad also exhibited more potent cytotoxicity than berberine and palmatine in mice with S180 sarcoma xenografted<em> in vivoem>. The primary screening results indicated that the 13-<em>n>-hexyl/13-<em>n>-octyl berberine and palmatine analogues might be valuable source for new potent anticancer drug candidates.

  7. The application of matrix metalloproteinase-3 and 7 joints ultrasonic score in assessment of disease activity in patients with rheumatoid arthritis%血清基质金属蛋白酶-3和7个关节超声评分在类风湿关节炎病情活动性评估中的应用

    Institute of Scientific and Technical Information of China (English)

    周凌; 宋婧; 陈凌; 徐沪济

    2016-01-01

    目的 探讨血清基质金属蛋白酶-3(MMP-3)和7个关节超声评分(US7评分)在类风湿关节炎(RA)患者病情活动性评估中的应用.方法 选2014年12月-2015年6月第二军医大学附属长征医院风湿免疫科确诊的RA患者133例,根据28个关节疾病活动指数(DAS28)分为稳定期(DAS28<2.6)、轻度活动期(DAS 28≥2.6 ~ <3.2)、中度活动期(DAS 28≥3.2~ <5.1)、重度活动期(DAS28 ≥5.1).另选同期健康体检者53例.免疫比浊法测所有受试者血清MMP-3水平.彩色多普勒超声观察RA患者7个关节,并进行US7评分.采用ROC曲线评判MMP-3、US7评分及MMP-3联合US7评分对RA疾病活动评估的效能.结果 中度活动期RA患者血清MMP-3水平为105.1(61.70,172.70) μg/L,重度活动期RA患者血清MMP-3水平为363.1(161.50,475.90) μg/L,高于健康体检者[35.20(25.90,48.90) μg/L;P<0.001]和稳定期RA患者[33.40(22.60,678.40)μg/L;P <0.001].重度活动期RA患者US7评分高于稳定期RA患者[7.0(2.5,11.0)比0(0,2.0);P<0.001].RA患者MMP-3水平与US7评分呈正相关(r=0.566,P<0.001).对RA病情活动评估,MMP-3联合US7评分(AUC为0.863 2)与MMP-3(AUC为0.854 3)比,差异无统计学意义(P>0.05);与US7评分(AUC为0.764 3)比,差异有统计学意义(P<0.01).结论 MMP-3和US7评分可以作为RA活动性的评价指标,特别是对中重度活动性RA患者.MMP-3与US7评分密切相关,但MMP-3和US7评分联合使用并未提高RA活动性的评价效能.%Objective To evaluate the significance of serum matrix metalloproteinase-3 (MMP-3) and joint ultrasonography in assessing the activity of rheumatoid arthritis (RA) by comparing MMP-3 level and the ultrasonic 7 joints (US7) score in RA patients.Methods Serum MMP-3 level and US7 score were measured in 133 RA patients by immune turbidity and Doppler ultrasound.Synchronous 53 healthy subjects were recruited as controls.Clinical data were collected.Erythrocyte sedimentation rate (ESR),serum level of

  8. Antioxidantes, atividade física e estresse oxidativo em mulheres idosas Antioxidants, physical activity and oxidative stress in older women

    Directory of Open Access Journals (Sweden)

    José Rubens Rebelatto

    2008-02-01

    Full Text Available OBJETIVO: Verificar a influência da suplementação de vitaminas antioxidantes na dieta de mulheres idosas que praticam exercícios físicos regulares, sobre o estresse oxidativo, indicadores da saúde física e risco de enfermidades cardiovasculares (ECV. MÉTODO: Foram observados dois grupos (S e C de mulheres com idades entre 60 e 80 anos participantes de um programa de atividades físicas durante 58 semanas, com freqüência de três vezes por semana e duração de 50 a 55 minutos cada sessão. A dieta habitual do Grupo S (n=36 foi suplementada diariamente com 330 ml de uma bebida antioxidante (FuncionaTM; o Grupo C (n=32 ingeriu água e se caracterizou como controle. Como indicadores do estresse oxidativo foram determinadas as concentrações plasmáticas de glutationa reduzida (GSH e oxidada (GSSG, calculada a relação molar GSH/GSSG, e identificado o dano oxidativo em lipídios e proteínas. As condições físicas e cardiovasculares foram avaliadas por meio dos parâmetros antropométricos habituais (peso, altura e índice de massa corporal e da pressão arterial. RESULTADOS: O Grupo C apresentou aumentos significativos do estresse oxidativo, redução da pressão arterial e dos valores médios de indicadores de risco de ECV. O Grupo S teve o estresse oxidativo reduzido significativamente e apresentou incremento dos ganhos cardiovasculares. Não foram identificadas significâncias em relação aos efeitos ergogênicos. CONCLUSÃO: Os dados indicam que mulheres idosas que realizam exercícios físicos freqüentes melhoram suas condições físicas e cardiovasculares e que o suplemento dietético continuado de alimentos funcionais antioxidantes podem minimizar os efeitos danosos das espécies reativas de oxigênio.OBJECTIVE: To verify the influence of dietary antioxidant supplementation in older women who regularly practice physical activities, on the occurrence of oxidative stress, physical health and risk of cardiovascular diseases

  9. Frontal and anterior cingulate activation during overt verbal fluency in patients with first episode psychosis Ativação frontal e do cíngulo anterior durante tarefa de fluência verbal em pacientes em primeiro episódio psicótico

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    Maristela Schaufelberger

    2005-09-01

    Full Text Available OBJECTIVE: Functional neuroimaging studies using phonological verbal fluency tasks allow the assessment of neural circuits relevant to the neuropsychology of psychosis. There is evidence that the prefrontal cortex and anterior cingulate gyrus present different activation patterns in subjects with chronic schizophrenia relative to healthy controls. We assessed the functioning in these brain regions during phonological verbal fluency in subjects with recent-onset functional psychoses, using functional magnetic resonance imaging (FMRI. METHODS: Seven patients with functional psychoses (3 schizophreniform, 4 affective and 9 healthy controls were studied. We compared functional magnetic resonance images acquired during articulation of words beginning with letters classified as easy for word production in Portuguese. Statistical comparisons were performed using non-parametric tests. RESULTS: There were no differences between patients and controls in task performance. Controls showed greater activation than patients in the left rostral anterior cingulate gyrus and right inferior prefrontal cortex, whereas patients showed stronger activation than controls in a more dorsal part of the anterior cingulate gyrus bilaterally and in a more superior portion of the right prefrontal cortex. CONCLUSION: Our preliminary findings of attenuated engagement of inferior prefrontal cortex and anterior cingulate gyrus in patients with recent onset psychosis during phonological verbal fluency are consistent with those of previous studies. The greater activation found in other parts of the anterior cingulate gyrus and prefrontal cortex in patients may be related to a compensatory response that is required to maintain normal task performance, and suggests a pattern of disorganized activity of different functional anterior cingulate gyrus units in association with psychotic conditions.OBJETIVO: Estudos de neuroimagem funcional empregando tarefa de fluência verbal fonol

  10. Estimativas de parâmetros genéticos para os escores visuais e suas associações com peso corporal em bovinos de corte Genetic parameters estimates for visual scores and their association with body weight in beef cattle

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    William Koury Filho

    2010-05-01

    effect and permanent maternal environment effect. Restricted maximum likelihood was employed for the estimation of genetic parameters. The heritability estimates of visual scores at weaning were 0.13, 0.25, 0.23 for conformation, finishing precocity, and musculature respectively. The heritability estimates of visual scores one year after weaning were greater: 0.24, 0.32 and 0.27 for conformation, finishing precocity, and musculature, respectively. The genetic correlations estimates among scores at the same ages were: 0.67 and 0.75 between conformation and finishing precocity; 0.61 and 0.71 between conformation and musculature; 0.95 and 0.95 between finishing precocity and musculature, considering weaning and one year further, respectively. The genetic correlations estimated between weaning weight and conformation, finishing precocity, and musculature, were 0.97, 0.67 and 0.62, respectively. The estimates among conformation, finishing precocity, musculature at year after weaning and body weight were 0.83, 0.59, 0.58, respectively. The results indicated that the visual scores can be used as selection criteria. Body weight increases can be expected as a correlated response for selection of such traits.

  11. Do MCAT scores predict USMLE scores? An analysis on 5 years of medical student data

    OpenAIRE

    Gauer, Jacqueline L.; Wolff, Josephine M.; Jackson, J. Brooks

    2016-01-01

    Introduction: The purpose of this study was to determine the associations and predictive values of Medical College Admission Test (MCAT) component and composite scores prior to 2015 with U.S. Medical Licensure Exam (USMLE) Step 1 and Step 2 Clinical Knowledge (CK) scores, with a focus on whether students scoring low on the MCAT were particularly likely to continue to score low on the USMLE exams.Method: Multiple linear regression, correlation, and chi-square analyses were performed to determi...

  12. Do MCAT scores predict USMLE scores? An analysis on 5 years of medical student data

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    Jacqueline L. Gauer

    2016-09-01

    Full Text Available Introduction: The purpose of this study was to determine the associations and predictive values of Medical College Admission Test (MCAT component and composite scores prior to 2015 with U.S. Medical Licensure Exam (USMLE Step 1 and Step 2 Clinical Knowledge (CK scores, with a focus on whether students scoring low on the MCAT were particularly likely to continue to score low on the USMLE exams. Method: Multiple linear regression, correlation, and chi-square analyses were performed to determine the relationship between MCAT component and composite scores and USMLE Step 1 and Step 2 CK scores from five graduating classes (2011–2015 at the University of Minnesota Medical School (N=1,065. Results: The multiple linear regression analyses were both significant (p<0.001. The three MCAT component scores together explained 17.7% of the variance in Step 1 scores (p<0.001 and 12.0% of the variance in Step 2 CK scores (p<0.001. In the chi-square analyses, significant, albeit weak associations were observed between almost all MCAT component scores and USMLE scores (Cramer's V ranged from 0.05 to 0.24. Discussion: Each of the MCAT component scores was significantly associated with USMLE Step 1 and Step 2 CK scores, although the effect size was small. Being in the top or bottom scoring range of the MCAT exam was predictive of being in the top or bottom scoring range of the USMLE exams, although the strengths of the associations were weak to moderate. These results indicate that MCAT scores are predictive of student performance on the USMLE exams, but, given the small effect sizes, should be considered as part of the holistic view of the student.

  13. A double-blind comparison of two creams containing urea as the active ingredient. Assessment of efficacy and side-effects by non-invasive techniques and a clinical scoring scheme.

    Science.gov (United States)

    Serup, J

    1992-01-01

    From a group of 72 healthy individuals, 47 with evidence of dry skin according to measurements by non-invasive techniques were enrolled for a 3-week study with double-blind and randomized treatment of one forearm, using either 3% urea cream (HTH lotion 'light') or 10% urea cream (HTH lotion 'Original'). The contralateral forearm served as an untreated control. Two volunteers had to be excluded because measurements of skin surface lipids gave evidence of vehicle components on the skin surface at the time of final evaluations. Evaluations took place not less than 12 h after the last application. According to questionnaire replies, the two creams were equally effective. This was confirmed by "blind" evaluation of the skin hydration state by a dermatologist, measurements of electrical capacitance and conductance indicating epidermal and skin surface hydration, and by D-Squame tape assessments including optical transmission of tapes with stratum corneum and scales from adhering skin, as well as visual scoring of the tapes. The methods showed a high degree of correlation, i.a. a definite relation between increase in electrical hydration parameters, reduced scaling according to the D-Squame tape evaluations, and clinical improvement of dryness. In skin treated with 10% urea cream the transepidermal water loss (TEWL) decreased, indicating an improved water barrier function. Skin colour measurement according to the CIE colour system showed that skin treated with the 3% urea cream turned in the direction of yellow, and there was generally a tendency for the brightness to decrease. Thus, the 3% urea cream gave the skin a more golden colour. There was no change in redness with any of the creams. Neither data from the questionnaire, the clinical examination, nor results of TEWL and colour measurements indicated any local irritant effect of urea causing water barrier damage or inflammation. In conclusion, the 3% and 10% urea creams were both found efficient, resulting in

  14. THE EFFICIENCY OF TENNIS DOUBLES SCORING SYSTEMS

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    Geoff Pollard

    2010-09-01

    Full Text Available In this paper a family of scoring systems for tennis doubles for testing the hypothesis that pair A is better than pair B versus the alternative hypothesis that pair B is better than A, is established. This family or benchmark of scoring systems can be used as a benchmark against which the efficiency of any doubles scoring system can be assessed. Thus, the formula for the efficiency of any doubles scoring system is derived. As in tennis singles, one scoring system based on the play-the-loser structure is shown to be more efficient than the benchmark systems. An expression for the relative efficiency of two doubles scoring systems is derived. Thus, the relative efficiency of the various scoring systems presently used in doubles can be assessed. The methods of this paper can be extended to a match between two teams of 2, 4, 8, …doubles pairs, so that it is possible to establish a measure for the relative efficiency of the various systems used for tennis contests between teams of players.

  15. Atividade antibacteriana de óleos essenciais em cepas isoladas de infecção urinária Antibacterial activity of essential oils on microorganisms isolated from urinary tract infection

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    Rogério Santos Pereira

    2004-04-01

    Full Text Available A análise da atividade antibacteriana de óleos essenciais de ervas medicinais (Ocimum gratissimum, L., Cybopogum citratus (DC Stapf. e Salvia officinalis, L. foi verificada frente a 100 cepas de bactérias isoladas de indivíduos da comunidade com diagnóstico de infecção urinária. Os microrganismos foram semeados em ágar Muller Hinton e os extratos aplicados com replicador de Steers e incubados a 37°C por 24 horas. Verificou-se que Salvia officinalis, L. apresentou ação inibitória superior às outras ervas, tendo eficácia de 100% quando testadas em espécies de Klebsiella e Enterobacter, 96% em Escherichia coli, 83% contra Proteus mirabilis e 75% contra Morganella morganii.The antibacterial activity of essential oils extracted from medicinal plants (Ocimum gratissimum, L., Cybopogum citratus (DC Stapf., and Salvia officinalis, L. was assessed on bacterial strains derived from 100 urine samples. Samples were taken from subjects diagnosed with urinary tract infection living in the community. Microorganisms were plated on Müller Hinton agar. Plant extracts were applied using a Steers replicator and petri dishes were incubated at 37°C for 24 hours. Salvia officinalis, L. showed enhanced inhibitory activity compared to the other two herbs, with 100% efficiency against Klebsiella and Enterobacter species, 96% against Escherichia coli, 83% against Proteus mirabilis, and 75% against Morganella morganii.

  16. CÁLCULO DO CUSTO DAS ATIVIDADES DE GESTÃO AMBIENTAL: APLICAÇÃO DO CUSTEIO BASEADO EM ATIVIDADES NUMA MONTADORA DE ÔNIBUS ENVIRONMENTAL MANAGEMENT COST CALCULATION: ACTIVITY BASED COSTING APPLIED TO BUS ASSEMBLY PROCESS

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    Orlando Durán

    2007-08-01

    Full Text Available Este trabalho apresenta os resultados da aplicação da metodologia de custeio baseado em atividades para medir o impacto que as atividades de gestão ambiental podem ter no custo industrial dos produtos. Um estudo de caso é apresentado junto com a utilização de um software comercial para o cálculo dos custos.This manuscript presents an Activity Based Costing application in an environmental protection context. The aim of this work is measuring the impact of environmental management activities on product costs. Also, a case study is discussed and the utilization of commercial software is presented.

  17. N-partitioning, nitrate reductase and glutamine synthetase activities in two contrasting varieties of maize Partição de nitrogênio e atividade das enzimas nitrato redutase e glutamina sintetase em duas cultivares contrastantes de milho

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    Altair Toledo Machado

    2001-02-01

    Full Text Available In order to identify useful parameters for maize genetic breeding programs aiming at a more efficient use of N, two maize varieties of contrasting N efficiency, Sol da Manhã NF (efficient and Catetão (inefficient were compared. Experiments were carried out under field and greenhouse conditions, at low and high N levels. The parameters analysed included total and relative plant and grain N content, biomass and the activities of nitrate reductase and glutamine synthetase in different parts of the plant. It was found that the translocation efficiency of N and photoassimilates to the developing seeds and the source-sink relations were significantly different for the two varieties. N content of the whole plant and grain, cob weight and the relative ear dry weight were useful parameters for characterizing the variety Sol da Manhã NF as to its efficient use of N. Enzymes activity of glutamine synthetase (transferase reaction and nitrate reductase did not differ among the varieties.Com o objetivo de identificar parâmetros que possam ser utilizados em programas de melhoramento genético em milho para uso eficiente de N, duas cultivares de milho contrastantes quanto ao uso deste nutriente, Sol da Manhã NF (eficiente e Catetão (não-eficiente, foram avaliadas em dois experimentos conduzidos no campo e em casa de vegetação, respectivamente, sob nível baixo e alto de N. Os caracteres avaliados foram: teor e conteúdo de N em diferentes partes da planta; massa seca; peso dos grãos e de diferentes partes da planta; biomassa, e atividade das enzimas nitrato redutase e glutamina sintetase. O mecanismo de translocação de N e de fotoassimilados para os grãos e a relação fonte/dreno foram importantes para diferenciar a cultivar eficiente da não-eficiente. Conteúdo de N nos grãos e total das plantas, peso do sabugo e relação peso de espiga/matéria seca foram importantes para caracterizar a cultivar Sol da Manhã NF eficiente no uso do N. A

  18. Kernel score statistic for dependent data.

    Science.gov (United States)

    Malzahn, Dörthe; Friedrichs, Stefanie; Rosenberger, Albert; Bickeböller, Heike

    2014-01-01

    The kernel score statistic is a global covariance component test over a set of genetic markers. It provides a flexible modeling framework and does not collapse marker information. We generalize the kernel score statistic to allow for familial dependencies and to adjust for random confounder effects. With this extension, we adjust our analysis of real and simulated baseline systolic blood pressure for polygenic familial background. We find that the kernel score test gains appreciably in power through the use of sequencing compared to tag-single-nucleotide polymorphisms for very rare single nucleotide polymorphisms with <1% minor allele frequency.

  19. Phenolic Antioxidants Isolated from the Flowers of <em>Osmanthus fragransem>

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    Kuo-Yu Li

    2012-09-01

    Full Text Available <em>O. fragransem> has slightly less antioxidative activity than green tea. Five phenolic compounds, tyrosyl acetate (1, (+-phillygenin (2, (8<em>E>-ligustroside (3, rutin (4, and verbascoside (5, were isolated from the CHCl3 sub-extract of <em>O. fragransem>. The structures were elucidated by interpreting their spectral data. Evaluation of the antioxidative property of the isolated (+-phillygenin (2, rutin (4, and verbascoside (5 revealed strong DPPH radical scavenging activity, with IC50 values of 19.1, 10.3, and 6.2 μM, respectively. These isolates also exhibited an H2O2 scavenging ability, with IC50 values of 10.5, 23.4, and 13.4 μM, respectively.

  20. A atividade de ensino e o desenvolvimento do pensamento teórico em matemática The learning activity and the development of theoretical thought in Mathematics

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    Wellington Lima Cedro

    2010-01-01

    Full Text Available Neste artigo, buscamos refletir sobre a formação do pensamento teórico-matemático nos estudantes, tomando por base os pressupostos da perspectiva histórico-cultural. Apoiando-nos em estudos de Vigotski, Leontiev, Davídov e, mais recentemente, de Moura e Lanner de Moura, discutimos a relação entre o ensino, a aprendizagem e a formação do pensamento teórico em Matemática, tendo como base a atividade de ensino.In this paper we looked for reflecting on the mathematical theoretical thought development in students, taking into consideration a historical-cultural approach. With support on studies of Vigotski, Leontiev, Davídov and, more recently, Moura and Lanner de Moura, we discuss the relation between teaching, learning and the development of theoretical thought in Mathematics, having as basis the learning activity.

  1. Tuberculose pulmonar: achados na tomografia computadorizada de alta resolução do tórax em pacientes com doença em atividade comprovada bacteriologicamente Pulmonary tuberculosis: findings on high resolution computerized tomography of active disease on patients with bacteriological confirmation

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    CRISTIANE ALÓ CAMPOS

    2002-01-01

    Full Text Available Objetivo: Descrever os achados em pacientes com tuberculose pulmonar em atividade na tomografia computadorizada de alta resolução e o padrão de distribuição das lesões pelo parênquima pulmonar. Casuística e método: Foram analisadas retrospectivamente as tomografias de alta resolução de 42 pacientes com diagnóstico bacteriológico de tuberculose pulmonar ou forte suspeita clínica, com posterior confirmação bacteriológica. Resultados: Os principais sinais sugestivos de atividade encontrados foram nódulos do espaço aéreo (83%, nódulos centrolobulares (74%, aspecto de árvore em brotamento (67%, cavitações (67%, espessamento das paredes brônquicas (55%, consolidações (48%, opacidade em vidro fosco (21%, e espessamento do interstício pulmonar (9%. Conclusão: A tomografia computadorizada de alta resolução do tórax pode sugerir fortemente atividade da doença, sendo particularmente útil nos pacientes com baciloscopias negativas e/ou radiografias indeterminadas, permitindo a instituição de tratamento adequado, antes mesmo do crescimento da micobactéria em meio de cultura.Background: The aim of this study was to describe the signs of active tuberculosis in patients submitted to high resolution computerized tomography and the distribution of lesions along the pulmonary parenchyma. Material and methods: The high resolution CTs performed on 42 patients with tuberculosis either bacteriologically diagnosed or clinical suspected and later confirmed by bacteriological tests were studied. Results: The signs of disease activity observed were airspace nodule (83%, centrilobular nodule (74%, tree-in-bud pattern (67%, cavitations (67%, bronchial thickening (55%, parenchymal consolidations (48%, ground glass opacity (21% and thickening of the inter and intralobular septa (9%. Conclusion: High resolution computed tomography can be strongly suggestive of disease activity, is particularly helpful in patients with negative smear and

  2. Pós-alta em Hanseníase no Ceará: limitação da atividade funcional, consciência de risco e participação social Pos-alta hospitalária en Lepra en Ceará: limitación de actividad funcional, conciencia de riesgo y participación social Post-treatment of Leprosy in Ceará: activity and functional limitation, safety awareness and social participation

    Directory of Open Access Journals (Sweden)

    Jaqueline Caracas Barbosa

    2008-11-01

    Full Text Available Caracterizar a limitação funcional, de atividade, consciência de risco, e restrição à participação social em pessoas atingidas pela hanseníase no pós-alta. Estudo seccional-descritivo com 69 residentes em Sobral, Ceará, com alta entre 2003 a 2005. Foram realizados exame físico dermato-neurológico, avaliação demográfica, de limitação funcional-atividade-consciência de risco e de restrição à participação social. Vinte (28,9% apresentaram escores SALSA 19 e 20 e escore EHF zero. O maior escore EHF foi alcançado por dois participantes, com 25 e 28 na escala SALSA. Na escala de participação 37 (53,6% não apresentaram restrição e tinham escore EHF zero. Dois (2,9% com escore EHF zero tinham leve restrição e 1 (1,5%, grande restrição. Reafirma-se a potencialidade destas ferramentas para a atenção integral aos portadores.Caracterizar la limitación funcional de actividad, conciencia de riesgo y restricción a la participación social en personas atingidas por la lepra en el post-alta. Estudio seccional y descriptivo con 69 sitiados en Sobral, Ceará, con alta entre 2003 y 2005. Fueron hechos examen físico dermatológico y además neurológico, evaluación demográfica, de limitación funcional, actividad y conciencia de riesgo y de restricción a la participación social. Veinte (28,9% presentaron escores SALSA 19 y 20 escore EHF cero. La mayor EHF fue alcanzada por dos participantes, con 25 y 28 años en la escala SALSA. En la categoría participación, 37 (53,6% no presentaron restricción y tenían escore EHF cero. Dos (2,9% con EHF cero tenían poca restricción y 1 (1,5%, gran restricción. Delante de eso, se afirma una vez más la potencialidad de éstas herramientas para la atención integral a los portadores.To characterize the functional limitation, activity limitation, risk conscience, and the social participation in people reached by hansen's disease in the post-MDT period. Cross-sectional, descriptive

  3. Scoring sacroiliac joints by magnetic resonance imaging. A multiple-reader reliability experiment

    DEFF Research Database (Denmark)

    Landewe, Robert B.M.; Hermann, Kay Geert A; Van Der Heijde, Desiree M.F.M

    2005-01-01

    Magnetic resonance imaging (MRI) of the sacroiliac (SI) joints and the spine is increasingly important in the assessment of inflammatory activity and structural damage in clinical trials with patients with ankylosing spondylitis (AS). We investigated inter-reader reliability and sensitivity...... electronically to 7 experienced readers from different countries (Europe, Canada). Readers scored the MRI by 3 different methods including: a global score (grading activity per SI joint); a more comprehensive global score (grading activity per SI joint per quadrant); and a detailed scoring system...... and sensitivity to change of scoring systems to be used in assessing activity of SI joints in clinical trials, and sets the conditions for further validation research in this field...

  4. Termite activity in relation to natural grassland soil attributes Atividade de térmitas em relação a atributos de solos sob campo nativo

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    Glaciela Kaschuk

    2006-12-01

    Full Text Available Soil-feeding termites transport soil for mound building, and this process can affect soil characteristics. To verify the influence of soil termite activity on soil characteristics, samples were collected from top, bottom and center of termite mounds, and of the adjacent area, to assess chemical and physical properties and mineralogical composition. Four replicates of termite mounds and respective adjacent areas were randomly sampled in Lages, Capão Alto, Painel, São José do Cerrito and Coxilha Rica (State of Santa Catarina, southern Brazil. Results of chemical analyses showed a greater content of K, P, Ca, Mg and organic C in the inner part of termite mounds, accompanied by lower pH in relation to soil of the adjacent area. There were no differences regarding clay mineral composition between termite mounds and adjacent soil, however the proportion of sand and clay differed between them. It is concluded that termites modify soil characteristics due to great volume of soil transported per ascensum for mound construction (varying from 20.9 m³ ha-1 to 136.6 m³ ha-1, in this study which promotes a strong pedo-bio-perturbation and affects nutrient cycling and soil physical properties.Os térmitas (cupins do solo carregam partículas de solo para construção de seus ninhos e desta forma, podem afetar algumas características pedológicas. Este estudo teve como objetivo verificar a influência da atividade de térmitas nas características do solo através de análises das propriedades químicas e físicas e da composição mineralógica de amostras coletadas na base, topo e centro dos ninhos e área de solo adjacente. Quatro cupinzeiros e suas respectivas áreas adjacentes foram aleatoriamente amostrados em Lages, Capão Alto, Painel, São José do Cerrito e Coxilha Rica (Santa Catarina. Os resutados das análises químicas mostraram que o conteúdo de K, P, Ca, Mg e C orgânico no centro dos ninhos foi maior e o pH menor em relação à área de

  5. Anti-inflammatory activity of Adenanthera pavonina L., Fabaceae, in experimental animals Atividade anti-inflamatória de Adenanthera pavonina L., Fabaceae, em animais experimentais

    Directory of Open Access Journals (Sweden)

    Arzumand Ara

    2010-12-01

    Full Text Available Adenanthera pavonina L, Fabaceae alt. Leguminosae, Bengali name 'rakta kombol', is an Indian medicinal plant. It is endemic to Southern China and India, and widely naturalized in Malaysia, Western and Eastern Africa as well as in most islands of both the Pacific and Caribbean regions. This plant has been used in traditional medicine for the treatment of asthma, boil, diarrhoea, gout, inflammations, rheumatism, tumour and ulcers, and as a tonic. The dried and ground bark of A. pavonina L. was extracted, successively, with petroleum ether (PE, dichloromethane (DCM, ethyl acetate (EtOAc and methanol (MeOH, and the resulting extracts were assessed in vivo for anti-inflammatory activity on carrageenan-induced rat hind paw oedema as a model of inflammation. The extracts were administered orally at the doses of 200 and 400 mg/kg body weight, and statistically significant (pAdenanthera pavonina L, Fabaceae, conhecida na região de Bengala por "rakta kombol", é uma planta medicinal endêmica do sul da China e da Índia e amplamente difundida na Malásia, África Ocidental e Oriental, bem como na maioria das ilhas de ambas as regiões do Pacífico e Caribe. Esta planta tem sido utilizada na medicina tradicional para o tratamento da asma, febre, diarréia, gota, inflamações, reumatismo tumor, úlceras, e como tônico. Cascas secas e moídas de A. pavonina foi submetida a extração sucessiva com éter de petróleo (PE, diclorometano (DCM, acetato de etila (AcOEt e metanol (MeOH, e os extratos foram avaliados in vivo para atividade anti-inflamatória induzida por carragenina tendo como ensaio modelo de inflamação edema de pata em ratos.. Os extratos foram administrados por via oral em doses de 200 e 400 mg/kg de peso corporal, e foram observadas efeitos anti-inflamatórios de maneira dose-dependente, estatisticamente significativos (p<0,001. O extrato metanólico (400 mg/kg apresentou 37,10% (p<0,01 de inibição da inflamação na primeira hora do

  6. Perspectives on EM metamaterials

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    Christophe Caloz

    2009-03-01

    Full Text Available Electromagnetic (EM metamaterials have become a field of intense research activities. This paper presents a critical perspective of the field, with emphasis on fundamental concepts and practical applications. Metamaterials are explained in the general context of periodic structures. Resonant particle type and transmission line type metamaterials are compared, and their fundamental connection is established. Exotic phenomena recently reported and associated challenges are briefly reviewed. Practical applications are enumerated and illustrated by an example. The paper concludes with an optimistic outlook regarding the future of metamaterials.

  7. GMAT Scores of Undergraduate Economics Majors

    Science.gov (United States)

    Nelson, Paul A.; Monson, Terry D.

    2008-01-01

    The average score of economics majors on the Graduate Management Admission Test (GMAT) exceeds those of nearly all humanities and arts, social sciences, and business undergraduate majors but not those of most science, engineering, and mathematics majors. (Contains 1 table.)

  8. Film scoring today - Theory, practice and analysis

    OpenAIRE

    Flach, Paula Sophie

    2012-01-01

    This thesis considers film scoring by taking a closer look at the theoretical discourse throughout the last decades, examining current production practice of film music and showcasing a musical analysis of the film Inception (2010).

  9. Multifactor Screener in OPEN: Scoring Procedures & Results

    Science.gov (United States)

    Scoring procedures were developed to convert a respondent's screener responses to estimates of individual dietary intake for percentage energy from fat, grams of fiber, and servings of fruits and vegetables.

  10. Use score card to boost quality.

    Science.gov (United States)

    2002-10-01

    Keeping a score card can identify problem areas and track improvements. When specific goals are reached, staff are given rewards such as thank-you letters, tokens, or pizza parties. Staff are kept informed about the results of the score card through bulletin board postings, staff meetings, and the hospital Intranet. Data are collected with manual entry by nursing staff, chart review by performance improvement, and a computerized program.

  11. Cardiovascular risk score in Rheumatoid Arthritis

    Science.gov (United States)

    Wagan, Abrar Ahmed; Mahmud, Tafazzul E Haque; Rasheed, Aflak; Zafar, Zafar Ali; Rehman, Ata ur; Ali, Amjad

    2016-01-01

    Objective: To determine the 10-year Cardiovascular risk score with QRISK-2 and Framingham risk calculators in Rheumatoid Arthritis and Non Rheumatoid Arthritis subjects and asses the usefulness of QRISK-2 and Framingham calculators in both groups. Methods: During the study 106 RA and 106 Non RA patients age and sex matched participants were enrolled from outpatient department. Demographic data and questions regarding other study parameters were noted. After 14 hours of fasting 5 ml of venous blood was drawn for Cholesterol and HDL levels, laboratory tests were performed on COBAS c III (ROCHE). QRISK-2 and Framingham risk calculators were used to get individual 10-year CVD risk score. Results: In this study the mean age of RA group was (45.1±9.5) for Non RA group (43.7±8.2), with female gender as common. The mean predicted 10-year score with QRISK-2 calculator in RA group (14.2±17.1%) and Non RA group was (13.2±19.0%) with (p-value 0.122). The 10-year score with Framingham risk score in RA group was (12.9±10.4%) and Non RA group was (8.9±8.7%) with (p-value 0.001). In RA group QRISK-2 (24.5%) and FRS (31.1%) cases with predicted score were in higher risk category. The maximum agreement scores between both calculators was observed in both groups (Kappa = 0.618 RA Group; Kappa = 0.671 Non RA Group). Conclusion: QRISK-2 calculator is more appropriate as it takes RA, ethnicity, CKD, and Atrial fibrillation as factors in risk assessment score. PMID:27375684

  12. Busca ativa de casos de leishmaniose cutânea em humanos e cães em área periférica do município de Campo Mourão - PR, Brasil Active search of cutaneous leishmaniasis in humans and canines in the peripherical area of Campo Mourão - PR - Brazil

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    Luís Antonio Sangioni

    2007-10-01

    Full Text Available Foi realizada uma busca ativa de casos de leishmaniose cutânea em humanos e cães, em área periférica da cidade de Campo Mourão - PR. No período de 01 a 30 de junho de 2004, uma equipe multidisciplinar visitou todas as residências e estabelecimentos comerciais situadas até 150m da margem superior e inferior do rio 119, que delimita o município. Todos os casos humanos suspeitos de Leishmaniose Tegumentar Americana (LTA foram encaminhados para o Posto de Saúde de referência para receberem os devidos tratamentos e orientação profilática. Foram encontrados 6 (seis casos de pessoas suspeitas de LTA, sendo que 04 (quatro resultaram em diagnóstico negativo e 02 (dois em diagnóstico positivo. Nenhum cão apresentou lesão suspeita de LTA.An active search was done to identify cases of leishmaniasis in humans and dogs in a peripherical area of Campo Mourão, PR, Brazil. From the first to thirtieth June of 2004, a multidisciplinary professional team visited all residences located within 150 meters from the superior and inferior margins of the river 119, which delimits the city. All human cases of American Tegumentary Leishmaniasis (ATL were directed to reference health care center for the appropriated treatment and prophylactic orientation. Six cases of persons suspected of ATL were found; four patients resulted in a negative diagnosis while two cases were positive. No dogs demonstrated lesions that were suggestive of ATL.

  13. Atividades amilolítica e pectinolítica de Alternaria solani e a relação com a agressividade em tomateiro Amilolytic and pectinolytic activities of Alternaria solani and aggressiveness in tomato plants

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    Carlos Eduardo Marchi

    2006-09-01

    Full Text Available As atividades amilolítica e pectinolítica de 45 isolados de Alternaria solani, provenientes de diferentes hospedeiros, foram estimadas por meio da difusão enzimática em meio sólido específico e mensuração do halo de degradação do substrato. Todos os isolados degradaram pectina. Apenas 17 isolados apresentaram atividade amilolítica, sendo nove isolados provenientes de batateira. Somente o isolado AS18 se destacou como bom produtor de ambas as enzimas. Uma vez que a atividade pectinolítica foi mais evidente, avaliou-se a influência de pectinases na agressividade de A. solani ao tomateiro. Para isso, cinco isolados (2 de berinjela, 2 de tomateiro e 1 de batateira contrastantes quanto à produção de pectinases foram selecionados para testes em folíolos destacados e plantas inteiras. Quatro isolados foram utilizados no teste em folíolos destacados (AS6, AS7, AS12 e AS26, e constatou-se haver variabilidade patogênica. A correlação obtida entre o tamanho das lesões e a atividade pectinolítica foi de r = 0,963 (P = 0,087. Cinco isolados (AS6, AS7, AS12, AS25 e AS26 foram inoculados em plantas inteiras de tomate. Os isolados não diferiram quanto ao número de lesões/cm² de área foliar, porém variaram em agressividade. Houve correlação (r = 0,916; P = 0,042 entre a atividade de pectinases e o índice de doença, sugerindo possível papel para as enzimas pécticas durante a infecção de A. solani em tomateiro. É provável que as diferenças no perfil enzimático dos isolados estejam associadas ao hospedeiro original de onde os mesmos foram obtidos. Os resultados reforçaram evidências de especificidade por hospedeiro em populações de A. solani.Amilolytic and pectinolytic activities of 45 isolates of Alternaria solani from distinct hosts were investigated. Enzyme secretion was evaluated in glucose-free medium amended with pectin or starch as carbon source. All isolates degraded pectin. Only 17 isolates had amilolytic

  14. Grau de satisfação discente frente à utilização de métodos ativos de aprendizagem em uma disciplina de Ética em saúde. Degree of student satisfaction with the use of active learning methodology in a discipline of Ethics in Health

    Directory of Open Access Journals (Sweden)

    Christofoletti, Gustavo

    2014-08-01

    Full Text Available O processo de ensino envolvendo os cursos da área da saúde é de extrema complexidade, por remeter à responsabilidade de formar profissionais qualificados para atender às necessidades da população. O modelo tradicional de ensino, centrado na figura do docente, vem sendo discutido e criticado, pelo fato de o aluno ser sujeito passivo na aquisição de conhecimento. O objetivo deste estudo foi aplicar técnicas de metodologia ativa de aprendizagem em uma disciplina de Ética em Saúde – modalidade semipresencial –, além de analisar o grau de satisfação dos alunos frente às atividades realizadas em sala de aula e em ambiente virtual. Sobre os métodos, foi realizado um estudo quali-quantitativo envolvendo 37 alunos que, delimitados sob situações-problemas e objetivos de aprendizagem, realizaram atividades presenciais e à distância em ambiente Moodle. Um instrumento foi aplicado para analisar o grau de satisfação do acadêmico e seu desempenho nas atividades. A técnica do Discurso do Sujeito Coletivo foi utilizada para realizar uma análise qualitativa dos resultados e o teste t de Student independente, para comparar, de forma quantitativa, as respostas dos alunos que aprovaram ou não a metodologia ativa. Sobre os resultados, 89,2% dos alunos aprovaram a metodologia ativa de aprendizagem, alegando melhor desempenho nas discussões. Mesmo diante da boa aceitação, alguns alunos relataram dificuldades adaptativas ao método, apesar não ter sido constatada diferença de rendimento entre os alunos (p=0,18. Os resultados reforçam a importância de se aplicarem métodos ativos de ensino em ambiente universitário e apontam para a necessidade de políticas que capacitem o docente nesta nova realidade. The process of teaching involving health care courses is extremely complex, and remits the responsibility to train qualified professionals to the needs of the population. The traditional model of education, centered on the figure of

  15. Factors associated to quality of life in active elderly Factores asociados a la calidad de vida en ancianos activos Fatores associados à qualidade de vida em idosos ativos

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    Tiago da Silva Alexandre

    2009-08-01

    TODOS: Estudo com amostra de 120 idosos ativos participantes de duas universidades abertas à terceira idade, nas cidades de São Paulo e São José dos Campos (SP, entre 2005 e 2006. A qualidade de vida foi mensurada utilizando a versão brasileira e reduzida do World Health Organization Quality Of Life (WHOQOL-bref. As variáveis sociodemográficas, clínicas e funcionais foram medidas por meio do Mini Mental State Examination, Geriatric Depression Scale, Functional Reach, One Leg Balance Test, Timed Up and Go Test, Six-Minute Walking Test, Human Activity Profile e questionário complementar. Foi realizada a análise descritiva simples, o coeficiente de correlação de Pearson, o teste T para amostras não relacionadas, a análise de variância, a análise de regressão linear e o cálculo do fator de inflação da variância. O nível de significância para todos os testes foi fixado em 0,05. RESULTADOS: A análise de regressão linear mostrou relação independente e sem colinearidade entre os quatro domínios do WHOQOL-bref e sintomas depressivos avaliados pela Geriatric Depression Scale. Não possuir vida conjugal implicou melhor percepção no domínio social; desenvolver atividades de lazer e possuir renda superior a cinco salários mínimos implicou melhor percepção no domínio meio ambiente. CONCLUSÕES: O estado funcional não foi capaz de influenciar o comportamento da variável qualidade de vida nos modelos de análise em idosos ativos, ao contrário dos fatores psicológicos avaliados pela Geriatric Depression Scale e das características sociodemográficas como estado civil, renda e prática de atividades de lazer.

  16. Trainee Occupational Therapists Scoring the Barthel ADL.

    Science.gov (United States)

    Martin, Elizabeth; Nugent, Chris; Bond, Raymond; Martin, Suzanne

    2015-09-01

    Within medical applications there are two main types of information design; paper-based and digital information [1]. As technology is constantly changing, information within healthcare management and delivery is continually being transitioned from traditional paper documents to digital and online resources. Activity of Daily Living (ADL) charts are still predominantly paper based and are therefore prone to "human error" [2]. In light of this, an investigation has taken place into the design for reducing the amount of human error, between a paper based ADL, specifically the Barthel Index, and the same ADL created digitally. The digital ADL was developed as an online platform as this offers the best method of data capture for a large group of participants all together [3]. The aim of the study was to evaluate the usability of the Barthel Index ADL in paper format and then reproduce the same ADL digitally. This paper presents the findings of a study involving 26 participants who were familiar with ADL charts, and used three scenarios requiring them to complete both a paper ADL and a digital ADL. An evaluation was undertaken to ascertain if there were any 'human errors' in completing the paper ADL and also to find similarities/differences through using the digital ADL. The results from the study indicated that 22/26 participants agreed that the digital ADL was better, if not the same as a paper based ADL. Further results indicated that participants rate highly the added benefit of the digital ADL being easy to use and also that calculation of assessment scores were performed automatically. Statistically the digital BI offered a 100 % correction rate in the total calculation, in comparison to the paper based BI where it is more common for users to make mathematical calculation errors. Therefore in order to minimise handwriting and calculation errors, the digital BI proved superior than the traditional paper based method.

  17. Avaliação da ação extensionista em universidades católicas e comunitárias Evaluation of extension activities in catholic and communitarian universities

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    Fabiana Marques Pereira Bartnik

    2009-07-01

    Full Text Available O presente artigo tem por objetivo compreender e analisar como as Universidades Católicas e Comunitárias estudadas realizam a avaliação de suas ações extensionistas. Entendemos que a avaliação do compromisso social da Ação Extensionista constitui um avanço na medida em que propicia a valorização e institucionalização da Extensão. Os resultados obtidos mostraram que em sua maioria, a avaliação da Ação Extensionista nestas Instituições é realizada de maneira informal e não concebida como um instrumento pedagógico que deveria avaliar os efeitos concretos dessas ações que se estendem à sociedade. Apesar disso, observa-se uma Extensão transformando-se em prática acadêmica interligada ao ensino e à pesquisa e significadas de aspectos que caracterizam as Instituições enquanto Católica e Comunitária.The purpose of the present article is to understand and analyze how the Catholic and Communitarian Universities perform the evaluation of their extension activities. The authors believe that the evaluation of the social commitment of these activities constitutes an advance since it values and institutionalizes Extension. The results obtained show that, in the majority of the institutions, the evaluation of the extension activities is performed informally and is not conceived as a pedagogical instrument that should evaluate the effects of these actions upon society. Nevertheless, one can observe that the Extension activities are being transformed into an academic practice in connection with education and research, with aspects that characterize the institutions as catholic and communitarian.

  18. Alimentazione di <em>Marmota marmotaem> in praterie altimontane delle dolomiti bellunesi

    Directory of Open Access Journals (Sweden)

    Alessandro Rudatis

    2006-03-01

    Full Text Available Abstract The diet of <em>Marmota marmotaem> in the mountain prairie of south-eastern Italian Alps. Diet composition of two family groups of alpine marmots was investigated in two areas of the Agordino’s Dolomites (Italian Alps in June-September 2001, by means of microscopic analysis of faeces and of direct observation of feeding activity. During the whole period of activity, a high consume of Angiosperms was confirmed, especially plants in flower; among them the “graminoids” seemed to play an important role only during the initial part of the active period. Generally vegetative parts predominated over flowers. The ingestion of animal preys was not confirmed by the analysis of droppings. Comparing diet composition of the two groups, Graminaceae (<em>Poa>, <em>Phleum>, Compositae (<em>Achillea>, Cyperaceae/Juncaceae, Leguminosae (<em>Anthyllis>, Rosaceae, and Labiatae (<em>Prunella>, <em>Stachys> formed the bulk of marmot diet in the study areas. Diet showed low diversity considering the abundance of plant species in the surrounding environment. Food resources were probably used in relation to their easy digestibility, with a high content in proteins, sugar and water. The knowledge of vegetation features in relation to marmot trophic habits can represent a useful tool for the management of this species. Riassunto Il regime alimentare di due gruppi di Marmotta alpina è stato studiato in giugno-settembre 2001 in due aree delle Dolomiti agordine (SE Italia, attraverso l’analisi microscopica delle feci e l’osservazione diretta dell’attività alimentare. Durante tutto il periodo di attività si è notato un forte consumo di Angiosperme, specialmente piante a fiore, mentre le ”graminoidi” sembra giochino un ruolo importante all’inizio della stagione. In generale le parti vegetali predominano sui fiori. L’ingestione di prede animali non è stata

  19. Estrutura foliar de curauá em diferentes intensidades de radiação fotossinteticamente ativa Leaf structure of curaua in different intensities of photosynthetically active radiation

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    Elaine Cristina Pacheco de Oliveira

    2008-02-01

    Full Text Available O objetivo deste trabalho foi caracterizar a anatomia foliar de Ananas comosus var. erectifolius e comparar as características anatômicas de suas fibras foliares, quando submetidas a dois índices de radiação fotossinteticamente ativa (54 e 100%. Para a análise das estruturas anatômicas, especialmente as fibras, foram utilizadas técnicas de dissociação da epiderme foliar, contagem do número de estômatos por milímetro quadrado, cortes histológicos e microscopia eletrônica de varredura no material botânico fixado. A epiderme estava revestida por cutícula espessa e bem desenvolvida nas folhas nos dois índices de radiação. Nas folhas a 100% de radiação fotossinteticamente ativa, foi observado aumento de espessura nas regiões apical e basal. Foram observadas diferenças no número de camadas e altura do parênquima paliçádico e na quantidade de feixes fibrosos relativas aos índices de radiação. A quantidade de feixes fibrosos foi maior na condição de 54% do que em 100% de radiação fotossinteticamente ativa.The aim of this work was to characterize the leaf anatomy of Ananas comosus var. erectifolius and to compare the anatomical characterists of its leaf fibres, when submitted to two levels of photosynthetically active radiation (54 and 100%. For the analysis of the anatomical structures, specially the fibres, the settled botanical material was submitted to techniques of dissociation of the foliar epidermis, microscopic number of stomata per square millimeter, cuts and scanning electron microscopy. The epidermis was coated for thick cuticle and developed well in leaves in the two intensity indexes of radiation. For leaves at 100% PAR a fast increase of thickness was observed in the apical and basal regions. Regarding the radiation levels, differences were observed in the number of layers, the height of palisade parenchyma, and in the amount of fibre beams. The amount of fibre beams was bigger at 54% than at 100% PAR.

  20. Atividade isoenzimática em plantas de trigo infectadas com o vírus SBWMV Isoenzymatic activity in wheat plants infected by virus SBWMV

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    Rocheli de Souza

    2005-09-01

    Full Text Available O objetivo deste trabalho foi elucidar a atividade e a expressão isoenzimática das esterases, das peroxidases e das aspartato aminotransferases em função da infecção de plantas de trigo pelo Soil-borne wheat mosaic virus (SBWMV. Foram analisadas, aos 45 dias após a emergência, quatro cultivares e uma linhagem de trigo, com diferentes níveis de resistência ao SBWMV: BRS Guabiju, BRS 194, BRS 179, BR 23 e PF 980524. De modo geral, ocorreram diferenças qualitativas e quantitativas intra e interpopulacional, quando comparadas plantas assintomáticas e sintomáticas ao SBWMV. Para o sistema esterase, nove padrões de bandas foram determinados e para peroxidase e aspartato aminotransferase foram detectados três padrões de bandas, para ambas as condições. Padrões eletroforéticos foram observados para plantas infectadas, quando comparadas com as não infectadas, destacando-se a atividade da esterase, o que permitiu identificar com maior precisão o estado metabólico e diferenciado das células.The aim of this work was to elucidate the effect of the Soil-borne wheat mosaic virus (SBWMV on the activity and on the isoenzymatic expression of esterases, peroxidases, and aspartate aminotranferases in wheat plants. Biochemical analyses were carried out for four cultivars and one line of wheat, 45 days after emergence with different levels of resistance to SBWMV: BRS Guabiju, BRS 194, BRS 179, BR 23 and PF 980524. In general, intra and interpopulation differences in quality and quantity were detected, when comparing plants with and without symptoms of SBWMV. Nine band patterns were determined in both situations for esterase. To peroxidase and aspartato aminotransferase, three band patterns were detected for both conditions. Eletrophoretic patterns of SBWMV infected plants were observed, when compared with noninfected ones, notably for esterase, which provides a more precise identification of cell metabolic condition.

  1. Avaliação da atividade antiinflamatória do coentro (Coriandrum sativum L. em roedores Evaluation of the anti-inflammatory activity of coriander (Coriandrum sativum L. in rodents

    Directory of Open Access Journals (Sweden)

    G Zanusso-Junior

    2011-01-01

    Full Text Available Coriandrum sativum L. (Umbelliferae, conhecido popularmente por coentro, é uma planta doméstica cultivada nas diversas partes do mundo, inclusive no Brasil. As folhas e frutos do coentro são utilizados como condimento em culinária e na medicina popular como analgésica, antirreumática, carminativa e colagoga. O objetivo deste estudo foi avaliar o efeito do tratamento com o óleo essencial (OEC e o extrato hidroalcóolico (EHC do coentro em modelos experimentais de inflamação em roedores. A atividade antiinflamatória do coentro foi avaliada por meio dos testes de pleurisia em ratos e formação do edema de orelha em camundongos. A pleurisia foi induzida pela carragenina em animais tratados ou não com EHC. O edema de orelha induzido pela aplicação tópica de óleo de cróton e a atividade da mieloperoxidase foi avaliada em camundongos tratados ou não com OEC ou EHC. No teste da pleurisia o tratamento com EHC promoveu significativa diminuição no edema pleural, mas não sobre a migração leucocitária. Além disso, diferentemente ao observado com o tratamento com OEC, o uso tópico de EHC diminui significativamente o edema de orelha e a migração celular induzidos pela aplicação do óleo de cróton. Os dados indicam que EHC apresenta atividade antiinflamatória quando administrado pelas via oral e tópica, enquanto que OEC não apresenta atividade antiinflamatória tópica.Commonly known as coriander, Coriandrum sativum L. (Umbelliferae is a home plant grown in several parts of the world, including Brazil. Its leaves and fruits have been used as condiment in cooking and in folk medicine as analgesic, antirheumatic, carminative and cholagogue. The aim of this study was to evaluate the effect of essential oil (EO and hydroalcoholic extract (HE from coriander on experimental inflammation models in rodents. Coriander anti-inflammatory activity was evaluated by pleurisy tests in rats and ear edema formation in mice. Pleurisy was induced

  2. Physiological-Social Scores in Predicting Outcomes of Prehospital Internal Patients

    Directory of Open Access Journals (Sweden)

    Abbasali Ebrahimian

    2014-01-01

    Full Text Available The physiological-social modified early warning score system is a newly developed instrument for the identification of patients at risk. The aim of this study was to investigate the feasibility of using the physiological-social modified early warning score system for the identification of patients that needed prehospital emergency care. This prospective cohort study was conducted with 2157 patients. This instrument was used as a measure to detect critical illness in patients hospitalised in internal wards. Judgment by an emergency medicine specialist was used as a measure of standard. Data were analyzed by using receiver operating characteristics curves and the area under the curve with 95% confidence interval. The mean score of the physiological-social modified early warning score system was 2.71 ± 3.55. Moreover, 97.6% patients with the score ≥ 4 needed prehospital emergency services. The area under receiver operating characteristic curve was 0.738 (95% CI = 0.708–0.767. Emergency medical staffs can use PMEWS ≥ 4 to identify those patients hospitalised in the internal ward as at risk patients. The physiological-social modified early warning score system is suggested to be used for decision-making of emergency staff about internal patients’ wards in EMS situations.

  3. Physiological-social scores in predicting outcomes of prehospital internal patients.

    Science.gov (United States)

    Ebrahimian, Abbasali; Seyedin, Hesam; Jamshidi-Orak, Roohangiz; Masoumi, Gholamreza

    2014-01-01

    The physiological-social modified early warning score system is a newly developed instrument for the identification of patients at risk. The aim of this study was to investigate the feasibility of using the physiological-social modified early warning score system for the identification of patients that needed prehospital emergency care. This prospective cohort study was conducted with 2157 patients. This instrument was used as a measure to detect critical illness in patients hospitalised in internal wards. Judgment by an emergency medicine specialist was used as a measure of standard. Data were analyzed by using receiver operating characteristics curves and the area under the curve with 95% confidence interval. The mean score of the physiological-social modified early warning score system was 2.71 ± 3.55. Moreover, 97.6% patients with the score ≥ 4 needed prehospital emergency services. The area under receiver operating characteristic curve was 0.738 (95% CI = 0.708-0.767). Emergency medical staffs can use PMEWS ≥ 4 to identify those patients hospitalised in the internal ward as at risk patients. The physiological-social modified early warning score system is suggested to be used for decision-making of emergency staff about internal patients' wards in EMS situations.

  4. Metodologias ativas de ensino-aprendizagem na formação profissional em saúde: debates atuais Active teaching-learning methodologies in health education: current debates

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    Sandra Minardi Mitre

    2008-12-01

    Full Text Available As vertiginosas transformações das sociedades contemporâneas têm colocado em questão, de modo cada vez mais incisivo, os aspectos relativos à formação profissional. Este debate ganha contornos próprios no trabalho em saúde, na medida em que a indissociabilidade entre teoria e prática, o desenvolvimento de uma visão integral do homem e a ampliação da concepção de cuidado tornam-se prementes para o adequado desempenho laboral. Com base nestas considerações, o objetivo do presente artigo é discutir as principais transformações metodológicas no processo de formação dos profissionais de saúde, com ênfase na apreciação das metodologias ativas de ensino-aprendizagem.The vertiginous transformations of the contemporary societies have been raising questions concerning aspects of professional education. Such questions have been raised in a more and more incisive way. This debate gains a new shape when applied to health work, where theory and practice cannot be dissociated, and where the development of an integral vision of the human being and the amplification of the concept care are essential for a proper performance. Based on these considerations, this article aims to discuss the main methodological transformations in the education process of health professionals, with emphasis to active teaching-learning methodologies.

  5. Avaliação da atividade elétrica atrial em pacientes submetidos ao tratamento cirúrgico da valvopatia mitral Evaluation of atrial electrical activity in patients operated on mitral valve disease

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    Cesar Augusto Ferreira

    2002-01-01

    Full Text Available INTRODUÇÃO: O acesso cirúrgico por esternotomia mediana e atriotomia subseptal clássica pode, em certos casos, resultar em má exposição da valva mitral. Incisões atriais alternativas otimizam a exposição da valva mitral mas podem interferir na atividade elétrica atrial pós-operatória. OBJETIVO: Padronizar método para investigar a atividade elétrica atrial para emprego em estudos comparativos de diferentes atriotomias em cardiopatas sumetidos à cirurgia cardíaca. MÉTODOS: Análise com eletrocardiograma convencional e de 24 h (sistema Holter, pré e pós-operatória, e cardioestimulação epicárdica pós-operatória pelo método de Narula, em 10 pacientes submetidos à correção de valvopatias mitrais. RESULTADOS: No pré-op., os pacientes em ritmo sinusal apresentaram ectopias supraventriculares, com episódios de taquicardia supraventricular em 57% dos casos, "flutter" atrial em 10% e ritmo juncional em 10%. Todos apresentaram ectopias ventriculares, de baixa incidência em 70% dos casos, e taquicardia ventricular não sustentada foi detectada em 30% dos pacientes. No pós-operatório, houve 40% de novas arritmias supraventriculares (fibrilação atrial, ritmo juncional, ritmo atrial baixo e taquicardia supraventricular paroxística, mas não ocorreram arritmias ventriculares. No pós-op. a função do nó sinusal não se alterou, ocorreu redução significativa das ectopias supraventriculares, com reversão de FA para ritmo sinusal em 1 paciente, mas não houve redução significativa das ectopias ventriculares. O tempo de condução inter-atrial correlacionou-se com o tamanho do átrio esquerdo. CONCLUSÃO: A metodologia mostrou-se adequada e segura, e poderá ser empregada na comparação de diferentes incisões atriais para exposição valvar mitral.INTRODUCTION: The selection of the surgical approach to the mitral valve is a critical factor in obtaining good exposure and minimizing lesions of the surrounding structures

  6. Atividade residual de herbicidas aplicados em pós-emergência na cultura da soja sobre o milheto cultivado em sucessão Effect of the residual activity of herbicides applied in post-emergence soybean on pearl millet grown in succession

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    H.A Dan

    2011-09-01

    Full Text Available O objetivo deste trabalho foi avaliar a atividade residual de herbicidas utilizados em pós-emergência da cultura da soja sobre o milheto cultivado em sucessão. O experimento foi realizado em Latossolo Vermelho distroférrico de textura argilosa em região de cerrado. Os herbicidas chlorimuron-ethyl (0,015 kg ha-1, imazethapyr (0,060 kg ha-1, imazethapyr (0,100 kg ha-1 e fomesafen (0,250 kg ha-1 foram utilizados em pós-emergência do cultivar de soja Msoy-6101. Utilizou-se o delineamento de blocos casualizados, com quatro repetições, em esquema de parcelas subdivididas (5 x 4. Nas subparcelas, realizou-se a semeadura do milheto (híbrido ADR-7010 em quatro períodos, correspondendo a 0, 40, 80 e 120 dias após a aplicação dos herbicidas (DAA. Durante a condução do ensaio, avaliou-se a intoxicação da cultura aos 7 e 28 dias após a emergência, o estande, a altura e a matéria seca da parte aérea das plantas de milheto. Ao final do ciclo da cultura, determinou-se o rendimento de grãos. O imazethapyr (0,060 kg ha-1 e chlorimuron-ethyl (0,015 kg ha-1 não alteraram significativamente o rendimento da cultura do milheto em semeaduras posteriores a 80 DAA. Para fomesafen, o intervalo mínimo de segurança entre a aplicação e a semeadura do milheto foi de 100 dias. Por outro lado, maior persistência foi observada para imazethapyr na dose 0,100 kg ha-1, chegando a 120 dias de bioatividade sobre o milheto, que teve seu rendimento de grãos alterando mesmo quando semeado durante esse período.The objective of this study was to evaluate the residual activity of herbicides used in post-emergence soybean on Pearl Millet grown in succession. The experiment was conducted in clay soil in cerrado region. The herbicides chlorimuron-ethyl (0.015 kg ha-1, imazethapyr (0.060 kg ha-1, imazethapyr (0.100 kg ha-1 and fomesafen (0.250 kg ha-1 were used in post-emergence soybean cultivar Msoy-6101, in plots of 80 m² that were subdivided into sub-plots of

  7. Heart valve surgery: EuroSCORE vs. EuroSCORE II vs. Society of Thoracic Surgeons score

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    Muhammad Sharoz Rabbani

    2014-12-01

    Full Text Available Background This is a validation study comparing the European System for Cardiac Operative Risk Evaluation (EuroSCORE II with the previous additive (AES and logistic EuroSCORE (LES and the Society of Thoracic Surgeons’ (STS risk prediction algorithm, for patients undergoing valve replacement with or without bypass in Pakistan. Patients and Methods Clinical data of 576 patients undergoing valve replacement surgery between 2006 and 2013 were retrospectively collected and individual expected risks of death were calculated by all four risk prediction algorithms. Performance of these risk algorithms was evaluated in terms of discrimination and calibration. Results There were 28 deaths (4.8% among 576 patients, which was lower than the predicted mortality of 5.16%, 6.96% and 4.94% by AES, LES and EuroSCORE II but was higher than 2.13% predicted by STS scoring system. For single and double valve replacement procedures, EuroSCORE II was the best predictor of mortality with highest Hosmer and Lemmeshow test (H-L p value (0.346 to 0.689 and area under the receiver operating characteristic (ROC curve (0.637 to 0.898. For valve plus concomitant coronary artery bypass grafting (CABG patients actual mortality was 1.88%. STS calculator came out to be the best predictor of mortality for this subgroup with H-L p value (0.480 to 0.884 and ROC (0.657 to 0.775. Conclusions For Pakistani population EuroSCORE II is an accurate predictor for individual operative risk in patients undergoing isolated valve surgery, whereas STS performs better in the valve plus CABG group.

  8. Peroxidase activity in roots of arracacha affected by pH and temperature = Atividade da peroxidase em raízes de batata-baroa afetada pelo pH e temperatura

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    Luciana Nunes Menolli

    2011-07-01

    Full Text Available In this paper, roots of arracacha (Arracacia xanthorrhyza Bancroft were stored at 5ºC to induce chilling injury symptoms and stress-related peroxidase activity. Later, peroxidase kinetic activity was determined in different pH and temperature conditions. For this, soluble crude extract was sequentially saturated with ammonium sulfate, obtaining a semi-purified enzyme solution used for the analysis. Activity of peroxidase induced by the chilling at 5oC was determined from pH 2.5 to 9.0 and at temperature ranging from 10 to80oC. The peroxidase had higher activity when the reaction occurred between pH 5.5 and 6.0 and at temperature of 30oC. Complete inactivation of the activity was observed in pH 2.5 after 60 minutes of pre-incubation or at 60oC for 10 minutes or alternatively at 70oCafter 5 minutes of pre-incubation. The enzyme is more susceptible to inactivation in acid than alkaline pHs or alternatively using heat treatment.Neste trabalho, raízes de batata-baroa (Arracacia xanthorrhiza Bancroft foram armazenadas a 5oC para induzir injúria por frio e expressar atividade da peroxidase de estresse. Posteriormente, a cinética de atividade foi determinada em diferentes condições depHs e temperatura. Para isto, extrato solúvel da raiz foi sequencialmente saturado com sulfato de amônio, obtendo-se uma preparação semi-purificada para a análise enzimática. Atividade peroxidativa induzida pela temperatura de armazenamento de 5oC foideterminada em pHs de 2,5 a 9,0 e a temperaturas de 10 a 80oC. A atividade da peroxidase foi maior quando a reação foi realizada nos pHs de 5,5 e 6,0 e temperatura de 30oC. A inativação completa da enzima ocorreu em pH de 2,5 após 60 min. de pré-incubação ou a60oC por 10 min., e alternativamente a 70oC após 5 min. de pré-incubação. A enzima foi mais susceptível à inativação em pH ácido do que alcalino, podendo também ser inativada pelo tratamento de calor.

  9. Five Ochna species have high antibacterial activity and more than ten antibacterial compounds

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    Jacobus N. Eloff

    2012-01-01

    Full Text Available New measures to control infections in humans and other animals are continuously being sought because of the increasing resistance of bacteria to antibiotics. In a wide tree screening survey of the antimicrobial activity of extracts of tree leaves (www.up.ac.za/phyto, <em>Ochna pulchraem>, a small tree found widely in southern Africa, had good antibacterial activity. We therefore investigated the antibacterial activity of acetone leaf extracts of some other available <em>Ochna> spp. Antibacterial activity and the number of antibacterial compounds in acetone leaf extracts of <em>Ochna natalitiaem>, <em>Ochna pretoriensisem>, <em>O. pulchraem>, <em>Ochna gamostigmataem> and <em>Ochna serullataem> were determined with a tetrazolium violet serial microplate dilution assay and bioautography against <em>Staphylococcus aureusem>, <em>Escherichia coliem>, <em>Enterococcus faecalisem> and <em>Pseudomonas aeruginosaem>, bacteria commonly associated with nosocomial infections. The percentage yields of the extracts varied from 2.5% to 8%. The minimum inhibitory concentrations of the five species ranged from 40 µg/mL to 1250 µg/mL. <em>E. coliem> was sensitive to all the extracts. The <em>O. pretoriensisem> extract was the most active with minimum inhibitory concentrations of 0.065 mg/mL and 0.039 mg/mL against <em>E. coliem> and <em>E. faecalisem>, respectively. The <em>O. pretoriensisem> extract also had the highest total activities of 923 mL/g and 1538 mL/g, indicating that the acetone extract from 1 g of dried plant material could be diluted to 923 mL or 1538 mL and would still kill these bacteria. Based on the bioautography results, the two most active species, <em>O. pretoriensisem> and <em>O. pulchraem>, contained at least 10 antibacterial compounds with similar Rf values. Some of these antibacterial compounds were polar and others were non-polar. Variation in the chemical composition of the species

  10. See It, Be It, Write It: Using Performing Arts to Improve Writing Skills and Test Scores

    Science.gov (United States)

    Blecher-Sass, Hope Sara; Moffitt, Maryellen

    2010-01-01

    Improve students' writing skills and boost their assessment scores while adding arts education, creativity, and fun to your writing curriculum. With this vibrant resource, improving writing skills goes hand-in-hand with improving test scores. Students learn how to use acting and visualization as prewriting activities to help them connect writing…

  11. Um estudo de impactos do roteamento dinâmico de veículos em atividades de prestação de serviço A study of impacts of dynamic vehicle routing on services production activities

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    Vitória Pureza

    2010-12-01

    Full Text Available Neste trabalho, é analisado o impacto da utilização de métodos de roteamento dinâmico de veículos em ambientes de prestação de serviço, onde a satisfação dos prazos de atendimento do cliente é prioritária. Com esse objetivo, é proposta uma heurística construtiva/desconstrutiva, que, quando acionada por um módulo de despacho de veículos, elabora rotas em tempo real. O impacto da aplicação da heurística é medido frente a outros métodos, utilizando- se conjuntos de instâncias geradas aleatoriamente, com base em dados fornecidos por uma empresa do setor de bebidas do interior do Estado de São Paulo. Os resultados indicam benefícios substanciais em termos de nível de serviço oferecido.In this paper we evaluate the impacts resulting from the incorporation of dynamic vehicle routing and scheduling in service production systems where due dates for service are a priority issue. We propose a constructive/deconstructive heuristic, which is activated by a dispatcher module in order to obtain routes in real time. The relative impact of the heuristic application to other methods is analyzed by means of sets of randomly generated instances, based on the data supplied by a drinks company in São Paulo State. The results indicate significant gains in terms of service level.

  12. Anthelmintic activity of Melia azedarach fruits in lambs naturally infected with gastrointestinal nematodes / Atividade anti-helmíntica do fruto da Melia azedarach em cordeiros naturalmente infectados com nematódeos gastrintestinais

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    Daniela Guzzo

    2008-08-01

    Full Text Available The aim of this study was to evaluate the anthelmintic activity of Melia azedarach grounded dry fruits, in lambs naturally infected with gastrointestinal nematodes. Twenty four (24 mixed-breed Ile de France x Corriedale, male lambs, aged 3 month, were separeted into three (3 groups of eight (8 animals: the first group was medicated with 5mg.Kg-1 of albendazole orally, in a single dose, the second group was medicated with 2g.Kg-1 of Melia azedarach fruits orally, in a single dose, and the third group remained untreated, as control. The results showed that the group that presented the best efficacy was the one treated with albendazole (51.96%, followed by the group treated with Melia azedarach fruits that presented 33.21% of efficacy.Objetivou-se neste trabalho avaliar a atividade anti-helmíntica dos frutos secos e moídos da planta Melia azedarach, em cordeiros naturalmente infectados com nematódeos gastrintestinais. Utilizou-se 24 cordeiros, com 90 dias de idade, machos, mestiços Ile de France x Corridale, os quais foram divididos em 3 grupos de oito animais cada, sendo: grupo 1, medicado com 5mg.Kg-1 em dose única, de albendazole pela via oral (V.O; grupo 2, com 2g.Kg-1 (V.O, em dose única, do fruto do cinamomo (Melia azedarach e o grupo 3, controle, não recebeu nenhum tipo de tratamento. Os resultados encontrados demonstraram que o grupo tratado com albendazole foi o que apresentou melhor eficácia 51.96%, seguido do grupo tratado com frutos de cinamomo o qual apresentou eficácia de 33.21%.

  13. Modificações nas atividades da poligalacturonase e pectinametilesterase em morangos armazenados a temperatura ambiente Modifications in the activities of poligalacturonase and pectinametilesterase in stored strawberries the ambient temperature

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    Polyanna Alves Silva

    2009-01-01

    Full Text Available Objetivou-se, neste trabalho, avaliar as modificações da poligalacturonase (PG e da pectinametilesterase (PME em morangos cultivados na região de Lavras, MG, e armazenados em temperatura ambiente. Foram utilizados morangos das cultivares 'Oso-grande', 'Toyorrinho' e 'Tudla'. Utilizou-se o delineamento inteiramente casualizado com 4 repetições, sendo os tratamentos arranjados em esquema fatorial (3X2, sendo 3 cultivares e 2 dias de análises (0 e 5 dias. A parcela experimental foi constituída por 10 frutos. Durante o armazenamento houve uma diminuição nos teores de pectina total e um aumento nos de pectina solúvel em todas as variedades analisadas. A atividade da PG e PME aumentaram com o período de armazenamento, independente da cultivar.The objective of this research was to evaluate the modifications of the polygalacturonase (PG and the pectinmethilesterase (PME in strawberries cultivated in the region of Lavras, MG, and stored at room temperature. Strawberries of the research were used for plantation of 'Oso-grande', 'Toyorrinho' and 'Tudla'. The entirely randomized design with 4 replicates was used, being the treatments arranged in factorial (3x2, being 3 plantations and 2 days of analyses (0 and 5 days. The experimental parcel was consisted by 10 fruits. During the storage there was a reduction in the levels of total pectin and an increase in the ones of soluble pectin in all the analyzed varieties. With the period of storage the PG and PME activity grew, independent of the cultivar.

  14. <em>luxS> Mutant Regulation: Quorum Sensing Impairment or Methylation Disorder?

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    Zhengwei Huang

    2012-05-01

    Full Text Available AI-2–mediated quorum sensing has been identified in various bacteria, including both Gram-negative and Gram-positive species, and numerous phenotypes have been reported to be regulated by this mechanism, using the <em>luxS>-mutant strain. But the AI-2 production process confused this regulatory function; some considered this regulation as the result of a metabolic change, which refers to an important metabolic cycle named activated methyl cycle (AMC, caused by<em> luxSem>-mutant simultaneously with the defect of AI-2. Herein we hypothesized that the quorum sensing system—not the metabolic aspect—is responsible for such a regulatory function. In this study, we constructed plasmids infused with<em> sahHem> and induced protein expression in the <em>luxS>-mutant strain to make the quorum-sensing system and metabolic system independent. The biofilm-related genes were investigated by real-time polymerase chain reaction (PCR, and the results demonstrated that the quorum-sensing completed strain restored the gene expression of the defective strain, but the metabolically completed one did not. This evidence supported our hypothesis that the autoinducer-2-mediated, quorum-sensing system, not the AMC, was responsible for <em>luxS> mutant regulation.

  15. Cultivo de embriões imaturos de citros em diferentes concentrações de carvão ativado e ácido giberélico Activated charcoal and giberellic acid concentrations on immature embryos culture

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    Edvan Alves Chagas

    2005-12-01

    Full Text Available Adição de carvão ativado e giberelina no meio de cultura podem proporcionar melhores condições no desenvolvimento de embriões imaturos de citros. Objetivou-se avaliar o efeito de carvão ativado e GA3 (ácido giberélico no cultivo de embriões imaturos provenientes do cruzamento entre laranjeira 'Pêra Rio' x tangerineira 'Poncã'. Após 118 dias da polinização, frutos imaturos, com 3 a 4 cm de diâmetro, foram coletados, suas sementes removidas e tratadas com álcool (70% por cinco minutos, hipoclorito de sódio (2% por 20 minutos e, posteriormente, lavadas três vezes em água destilada e autoclavada. Em condições assépticas, os tegumentos das sementes foram separados, os embriões globulares excisados e inoculados em tubos de ensaio contendo 15 mL do meio MT, acrescido de carvão ativado (0; 0,5; 1; 1,5 e 2 g L-1 e GA3 (0; 0,01; 0,1; 1 e 10 mg L-1. Após a inoculação, os embriões permaneceram por 90 dias em sala de crescimento a 27+1ºC, fotoperíodo de 16 horas e irradiância de 32 mmol m-2 s-1. Maior comprimento da parte aérea foi obtido em meio MT, acrescido de 0,1 e 1 mg L-1 de GA3, combinado com 2 g L-1 de carvão ativado. Maior comprimento do sistema radicular, massa da matéria fresca e número de folhas de plântulas foram obtidos em meio MT, acrescido de 0,01 mg L-1 de GA3, na ausência de carvão ativado. A adição de carvão ativado influenciou na concentração de ácido giberélico acrescido no meio de cultura.Activated charcoal and gibberelin provides better conditions on development of citrus immature embryos. Activated charcoal and GA3 (gibberelic acid on 'Pêra Rio' sweet orange x 'Poncã' mandarin immature embryos culture was evaluated. After 118 days-pollination, imature fruits with 3 to 4 cm of diameter were collected, seeds removed and treated with alcohol (70% for five min., sodium hypoclorite (2% for 20 min. and three times washed with distilled and autoclaved water. In aseptic conditions, the teguments

  16. RISK FACTOR DIAGNOSTIC SCORE IN DIABETIC FOOT

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    Mohamed Shameem P. M

    2016-09-01

    Full Text Available INTRODUCTION Diabetic foot ulcers vary in their clinical presentation and nature of severity and therefore create a challenging problem to the treating surgeon regarding the prediction of the clinical course and the end result of the treatment. Clinical studies have shown that there are certain risk factors for the progression of foot ulcers in diabetics and it may therefore be possible to predict the course of an ulcer foot at presentation itself, thus instituting proper therapy without delay. Spoken otherwise clinical scoring may tell that this particular ulcer is having highest chance of amputation, then one may be able to take an early decision for the same and avoid the septic complications, inconvenience to the patient, long hospital stay and cost of treatments. AIM OF THE STUDY Aim of the study is to evaluate the above-mentioned scoring system in predicting the course the diabetic foot ulcers. MATERIALS AND METHODS 50 patients with Diabetic Foot attending the OPD of Department of Surgery of Government Hospital attached to Calicut Medical College are included in the present study. After thorough history taking and clinical examination, six risk factors like Age, pedal vessels, renal function, neuropathy, radiological findings and ulcers were observed in the patients by giving certain scoring points to each of them. The total number of points scored by the patients at the time of admission or OPD treatment was correlated with the final outcome in these patients, whether leading to amputation or conservative management. All the data was analysed using standard statistical methods. OBSERVATIONS AND RESULTS There were 12 females and 38 males with a female to male ratio 1:3.1. All were aged above 30 years. Twenty-four (48% of them were between 30-60 years and twenty six (52% were above 60 years. 10 patients were treated conservatively with risk score range: 10 to 35. Six had single toe loss with risk score: 25 to 35. Six had multiple toe loss

  17. Combination of Oxyanion Gln114 Mutation and Medium Engineering to Influence the Enantioselectivity of Thermophilic Lipase from <em>Geobacillus zalihaeem>

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    Thean Chor Leow

    2012-09-01

    Full Text Available The substitution of the oxyanion Q114 with Met and Leu was carried out to investigate the role of Q114 in imparting enantioselectivity on T1 lipase. The mutation improved enantioselectivity in Q114M over the wild-type, while enantioselectivity in Q114L was reduced. The enantioselectivity of the thermophilic lipases, T1, Q114L and Q114M correlated better with log <em>p> as compared to the dielectric constant and dipole moment of the solvents. Enzyme activity was good in solvents with log <em>p> < 3.5, with the exception of hexane which deviated substantially. Isooctane was found to be the best solvent for the esterification of (<em>R,S>-ibuprofen with oleyl alcohol for lipases Q114M and Q114L, to afford <em>E> values of 53.7 and 12.2, respectively. Selectivity of T1 was highest in tetradecane with <em>E> value 49.2. Solvents with low log <em>p> reduced overall lipase activity and dimethyl sulfoxide (<em>DMSO> completely inhibited the lipases. Ester conversions, however, were still low. Molecular sieves employed as desiccant were found to adversely affect catalysis in the lipase variants, particularly in Q114M. The higher desiccant loading also increased viscosity in the reaction and further reduced the efficiency of the lipase-catalyzed esterifications.

  18. Estudos de QSAR-3D em derivados 5-nitro-2-tiofilidênicos com atividade frente a Staphylococcus aureus multi-resistente 3D QSAR studies of 5-nitrothiophene derivatives with antimicrobial activity against multidrug-resistant Staphylococcus aureus

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    Andrea Masunari

    2007-06-01

    Full Text Available Campos moleculares extraídos de aplicativos utilizados em estudos de QSAR-3D apresentam, em geral, grande número de informações, muitas vezes irrelevantes na expressão da atividade biológica. O programa Volsurf converte as informações presentes em mapas de energia de interação tridimensionais em número reduzido de descritores bidimensionais que se caracterizam como de fácil entendimento e interpretação. Assim, foram avaliados, neste estudo, dezoito derivados 5-nitro-2-tiofilidênicos com atividade antimicrobiana frente a Staphylococcus aureus multi-resistente, correlacionando as características tridimensionais destes ligantes com a referida atividade. Para o desenho e conversão tridimensional dos ligantes foram utilizados os aplicativos Sybyl (Tripos Inc e CORINA (Molecular Networks GmbH Computerchemie, respectivamente. Os campos de interação molecular foram calculados no programa GRID (Molecular Discovery Ltd. A aplicação do programa Volsurf (Molecular Discovery Ltd resultou em modelo estatisticamente robusto (r² = 0,93, q² = 0,87 com 48 descritores estruturais, mostrando ser a hidrofobicidade propriedade fundamental no condicionamento da atividade antimicrobiana.Studies in three-dimensional molecular fields generally contain a large amount of data, some of which are redundant or not relevant. The program Volsurf, a quite fast method, is able to compress the relevant information present in 3D molecular structures into a few easy bidimensional descriptors. This study correlates the antimicrobial activity of eighteen 5-nitro-2-thiophylidene derivatives against multidrug-resistant Staphylococcus aureus with three-dimensional molecular fields of these ligands. For molecular structures sketching and 3D conversion, Sybyl and CORINA programs were used, respectively. The GRID force field was applied to generate the 3D interaction energies. The Volsurf characterization results on significant statistic model with 48 descriptors (r

  19. Lectin from <em>Canavalia brasiliensisem> Seeds (ConBr Is a Valuable Biotechnological Tool to Stimulate the Growth of <em>Rhizobium tropiciem> <em>in Vitroem>

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    Ricardo Pires dos Santos

    2012-05-01

    Full Text Available To study the interactions between a <em>Rhizobium tropiciem> strain and lectins isolated from the seeds of <em>Canavalia ensiformisem> (ConA and <em>Canavalia brasiliensisem> (ConBr, a lectin fluorescence assay was performed. In addition, an experiment was designed to evaluate the effect of the two lectins on bacterial growth. Both lectins were found to bind to <em>R. tropiciem> cells, but the interactions were inhibited by D-mannose. Interestingly, only ConBr stimulated bacterial growth in proportion to the concentrations used (15.6–500 µg/mL, and the bacterial growth stimulation was inhibited by D-mannose as well. Structure/Function analyses by bioinformatics were carried out to evaluate the volume and carbohydrate recognition domain (CRD configuration of ConA and ConBr. The difference of spatial arrangement and volume of CRD may indicate the variation between biological activities of both lectins. The results suggest that ConBr could be a promising tool for studies focusing on the interactions between rhizobia and host plants.

  20. Gambling scores for earthquake predictions and forecasts

    Science.gov (United States)

    Zhuang, Jiancang

    2010-04-01

    This paper presents a new method, namely the gambling score, for scoring the performance earthquake forecasts or predictions. Unlike most other scoring procedures that require a regular scheme of forecast and treat each earthquake equally, regardless their magnitude, this new scoring method compensates the risk that the forecaster has taken. Starting with a certain number of reputation points, once a forecaster makes a prediction or forecast, he is assumed to have betted some points of his reputation. The reference model, which plays the role of the house, determines how many reputation points the forecaster can gain if he succeeds, according to a fair rule, and also takes away the reputation points betted by the forecaster if he loses. This method is also extended to the continuous case of point process models, where the reputation points betted by the forecaster become a continuous mass on the space-time-magnitude range of interest. We also calculate the upper bound of the gambling score when the true model is a renewal process, the stress release model or the ETAS model and when the reference model is the Poisson model.

  1. Disease severity scoring systems in dermatology

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    Cemal Bilaç

    2016-06-01

    Full Text Available Scoring systems have been developed to interpret the disease severity objectively by evaluating the parameters of the disease. Body surface area, visual analogue scale, and physician global assessment are the most frequently used scoring systems for evaluating the clinical severity of the dermatological diseases. Apart from these scoring systems, many specific scoring systems for many dermatological diseases, including acne (acne vulgaris, acne scars, alopecia (androgenetic alopecia, tractional alopecia, bullous diseases (autoimmune bullous diseases, toxic epidermal necrolysis, dermatitis (atopic dermatitis, contact dermatitis, dyshidrotic eczema, hidradenitis suppurativa, hirsutismus, connective tissue diseases (dermatomyositis, skin involvement of systemic lupus erythematosus (LE, discoid LE, scleroderma, lichen planoplaris, mastocytosis, melanocytic lesions, melasma, onychomycosis, oral lichen planus, pityriasis rosea, psoriasis (psoriasis vulgaris, psoriatic arthritis, nail psoriasis, sarcoidosis, urticaria, and vitiligo, have also been developed. Disease severity scoring methods are ever more extensively used in the field of dermatology for clinical practice to form an opinion about the prognosis by determining the disease severity; to decide on the most suitable treatment modality for the patient; to evaluate the efficacy of the applied medication; and to compare the efficiency of different treatment methods in clinical studies.

  2. SCORE SETS IN ORIENTED 3-PARTITE GRAPHS

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Let D(U, V, W) be an oriented 3-partite graph with |U|=p, |V|=q and |W|= r. For any vertex x in D(U, V, W), let d+x and d-x be the outdegree and indegree of x respectively. Define aui (or simply ai) = q + r + d+ui - d-ui, bvj(or simply bj) = p + r + d+vj - d-vj and Cwk (or simply ck) = p + q + d+wk - d-wk as the scores of ui in U, vj in V and wk in Wrespectively. The set A of distinct scores of the vertices of D(U, V, W) is called its score set. In this paper, we prove that if a1 is a non-negative integer, ai(2≤i≤n - 1) are even positive integers and an is any positive integer, then for n≥3, there exists an oriented 3-partite graph with the score set A = {a1,2∑i=1 ai,…,n∑i=1 ai}, except when A = {0,2,3}. Some more results for score sets in oriented 3-partite graphs are obtained.

  3. [Overview of regulatory aspects guiding tablet scoring].

    Science.gov (United States)

    Teixeira, Maíra Teles; Sá-Barreto, Lívia Cristina Lira; Silva, Dayde Lane Mendonça; Cunha-Filho, Marcílio Sergio Soares

    2016-06-01

    Tablet scoring is a controversial but common practice used to adjust doses, facilitate drug intake, or lower the cost of drug treatment, especially in children and the elderly. The risks of tablet scoring are mainly related to inaccuracies in the resulting dose and stability problems. The aim of this article is to provide an overview of worldwide guidelines regarding tablet scoring. We found that regulatory health agencies in Mercosur countries as well as other South American countries do not have published standards addressing tablet splitting. Among the surveyed health agencies, the Food and Drug Administration (FDA) in the United States is the only one to present standards, ranging from splitting instructions to regulation of the manufacturing process. The concept of functional scoring implemented by the FDA has introduced some level of guarantee as to the ability of tablets to be split. In conclusion, technical and scientific bases are still insufficient to guide health rules on this subject, making the decision on scoring, in certain situations, random and highly risky to public health. The need for more detailed regulation is vital to ensure the safety of tablet medications.

  4. A scoring framework for predicting protein structures

    Science.gov (United States)

    Zou, Xiaoqin

    2013-03-01

    We have developed a statistical mechanics-based iterative method to extract statistical atomic interaction potentials from known, non-redundant protein structures. Our method circumvents the long-standing reference state problem in deriving traditional knowledge-based scoring functions, by using rapid iterations through a physical, global convergence function. The rapid convergence of this physics-based method, unlike other parameter optimization methods, warrants the feasibility of deriving distance-dependent, all-atom statistical potentials to keep the scoring accuracy. The derived potentials, referred to as ITScore/Pro, have been validated using three diverse benchmarks: the high-resolution decoy set, the AMBER benchmark decoy set, and the CASP8 decoy set. Significant improvement in performance has been achieved. Finally, comparisons between the potentials of our model and potentials of a knowledge-based scoring function with a randomized reference state have revealed the reason for the better performance of our scoring function, which could provide useful insight into the development of other physical scoring functions. The potentials developed in the present study are generally applicable for structural selection in protein structure prediction.

  5. Antibacterial Secondary Metabolites from the Cave Sponge <em>Xestospongia em>sp.

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    Sridevi Ankisetty

    2012-05-01

    Full Text Available Chemical investigation of the cave sponge <em>Xestospongia em>sp. resulted in the isolation of three new polyacetylenic long chain compounds along with two known metabolites. The structures of the new metabolites were established by NMR and MS analyses. The antibacterial activity of the new metabolites was also evaluated.

  6. Atividade de enzimas associadas ao estado de indução em mudas de cacaueiro expostas a dois actinomicetos residentes de filoplano Activity of enzymes associates of induced resistance on cocoa seedlings exposed of two actinomycetes phylloplane residents

    Directory of Open Access Journals (Sweden)

    Dirceu Macagnan

    2008-02-01

    Full Text Available Dois antagonistas selecionados para o biocontrole da vassoura-de-bruxa do cacaueiro foram avaliados quanto à capacidade em ativar mecanismos de defesa de plantas contra patógenos. Para tanto, mudas seminais de cacaueiro "comum" foram cultivadas em casa-de-vegetação por 30 dias e expostas aos antagonistas aplicados a mudas de cacaueiro por atomização, individualmente e em associação. O primeiro par de folhas das mudas dos diferentes tratamentos foi coletado aos dois, quatro, 12 e 24 dias após a exposição aos antagonistas. Foi quantificada a atividade de peroxidases, polifenoloxidases, quitinases e beta-1,3-glucanases no material coletado. Observou-se um aumento na atividade de peroxidases e polifenoloxidases nos primeiros dias após a exposição das mudas, especialmente ao isolado Ac26. Não foi observado efeito aditivo ou sinergístico nas mudas expostas aos dois isolados simultaneamente.Two antagonists selected for the biocontrol of cocoa witches' broom were investigated for their ability in triggering increases in the activity of enzymes associated to induced resistance. In a greenhouse, thirty days old cocoa seedlings were exposed t antagonists by spraying a propagule suspension of every antagonist or a mixture of them. At two, four 12 and 24 days exposing plants to the antagonists, the first leaf pair of every plant was excised and used for quantifying the activity of peroxidases, poly-phenol-oxidases, chitinases and beta-1,3-glucanases. There were increases in activity of peroxidases, poly-phenol-oxidases, mainly in the case of isolate Ac26. Additive or synergistic effects were not observed as a consequence of exposing plants to both antagonists together.

  7. "SIGA OS EXEMPLOS" DOS ALUNOS: APRENDIZAGENS EM AULAS EXPLORATÓRIO-INVESTIGATIVAS NO 4o. ANO DO ENSINO FUNDAMENTAL. "FOLLOW THE EXAMPLES" OF STUDENTS: LEARNING IN EXPLORATORY-INVESTIGATIVE ACTIVITIES IN THE 4TH GRADE OF ELEMENTARY SCHOOL

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    Lamonato, Maiza

    2012-05-01

    Full Text Available Trata-se de uma pesquisa com abordagem qualitativa, que objetiva analisar as aprendizagens de uma professora e de seus alunos a partir de aulas exploratório-investigativas com conteúdo geométrico, desenvolvidas em um 4º ano do Ensino Fundamental. A professora participava de um curso de formação contínua e parte das aulas realizou-se junto com a primeira autora desse artigo que era formadora no referido curso. Os dados foram constituídos em videogravações e respectivas transcrições, narrativas orais e escritas da professora, diários de campo da pesquisadora, registros escritos dos alunos e fotografias. O diálogo com a literatura teve como interlocutor diversas pesquisas que tratam da exploração-investigação matemática em aulas do Ensino Fundamental e da aprendizagem do professor adulto, sujeito de sua permanente formação. O foco da análise deu-se em três atividades desenvolvidas. Os resultados apontam que para os alunos houve aprendizagens de conteúdos geométricos, envolvendo conceitos de figuras geométricas planas, ao uso da régua e a novos modos de participação em um contexto de argumentação e negociação de significados, permeados pela oralidade e pela escrita. Além disso, para a professora as aprendizagens centraram-se nos modos de conduzir tais aulas, favorecendo a participação das crianças para questionar e argumentar sobre as suas próprias produções ou de seus colegas e relacionaram-se à sua autonomia em decidir as prioridades na escolha das atividades e no gerenciamento do tempo em sala de aula. Destaca-se que as aulas sobre figuras geométricas planas podem partir dos exemplos feitos pelos próprios alunos, distanciando-se de um ensino de representações prontas.The aim of this study was to evaluate the learning of a teacher and her students in classes with exploratory-investigative geometrical content, developed in the 4th year of primary education. The teacher participated of a continuous

  8. Prognostic Value of TIMI Score versus GRACE Score in ST-segment Elevation Myocardial Infarction

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    Luis C. L. Correia

    2014-08-01

    Full Text Available Background: The TIMI Score for ST-segment elevation myocardial infarction (STEMI was created and validated specifically for this clinical scenario, while the GRACE score is generic to any type of acute coronary syndrome. Objective: Between TIMI and GRACE scores, identify the one of better prognostic performance in patients with STEMI. Methods: We included 152 individuals consecutively admitted for STEMI. The TIMI and GRACE scores were tested for their discriminatory ability (C-statistics and calibration (Hosmer-Lemeshow in relation to hospital death. Results: The TIMI score showed equal distribution of patients in the ranges of low, intermediate and high risk (39 %, 27 % and 34 %, respectively, as opposed to the GRACE Score that showed predominant distribution at low risk (80 %, 13 % and 7%, respectively. Case-fatality was 11%. The C-statistics of the TIMI score was 0.87 (95%CI = 0.76 to 0.98, similar to GRACE (0.87, 95%CI = 0.75 to 0.99 - p = 0.71. The TIMI score showed satisfactory calibration represented by χ2 = 1.4 (p = 0.92, well above the calibration of the GRACE score, which showed χ2 = 14 (p = 0.08. This calibration is reflected in the expected incidence ranges for low, intermediate and high risk, according to the TIMI score (0 %, 4.9 % and 25 %, respectively, differently to GRACE (2.4%, 25% and 73%, which featured middle range incidence inappropriately. Conclusion: Although the scores show similar discriminatory capacity for hospital death, the TIMI score had better calibration than GRACE. These findings need to be validated populations of different risk profiles.

  9. The rat whole embryo culture assay using the Dysmorphology Score system.

    Science.gov (United States)

    Zhang, Cindy; Panzica-Kelly, Julie; Augustine-Rauch, Karen

    2013-01-01

    The rat whole embryo culture (WEC) system has been used extensively for characterizing teratogenic properties of test chemicals. In this chapter, we describe the methodology for culturing rat embryos as well as a new morphological score system, the Dysmorphology Score (DMS) system for assessing morphology of mid gestation (gestational day 11) rat embryos. In contrast to the developmental stage focused scoring associated with the Brown and Fabro score system, this new score system assesses the respective degree of severity of dysmorphology, which delineates normal from abnormal morphology of specific embryonic structures and organ systems. This score system generates an approach that allows rapid identification and quantification of adverse developmental findings, making it conducive for characterization of compounds for teratogenic properties and screening activities.

  10. Imobilização da pancreatina em carvão ativado e em alumina para o preparo de hidrolisados de soro de leite - DOI: 10.4025/actascihealthsci.v27i2.1417 Immobilization of pancreatin in activated carbon and in alumina for preparing whey hydrolysates - DOI: 10.4025/actascihealthsci.v27i2.1417

    Directory of Open Access Journals (Sweden)

    Marialice Pinto Coelho Silvestre

    2005-03-01

    Full Text Available Tendo como objetivo a redução de custos do processo de fabricação de hidrolisados protéicos, estudou-se neste trabalho a imobilização da pancreatina, por adsorção, em carvão ativado e em alumina. Para isso, foram testadas diferentes condições de imobilização (30, 60 e 90min a 25°C, e 12h a 5°C. Para verificar a taxa de imobilização, determinou-se indiretamente a enzima não adsorvida nos suportes. Ao se utilizar o carvão ativado, não foi observada diferença significativa entre as condições testadas, tendo-se obtido 100% de imobilização enzimática. Para a alumina, a melhor condição foi a de 90min, na qual se obteve 37% de imobilização. A medida do grau de exposição da fenilalanina, pela espectrofotometria derivada segunda, foi empregada para a determinação da estabilidade operacional da enzima, tendo sido mostrado que a imobilização em carvão ativado e em alumina permitiu a reutilização da pancreatina por até 5 vezes e 2 vezes, respectivamenteImmobilization of pancreatin in activated carbon and in alumina was studied for producing protein hydrolysates, in order to reduce the process costs. Different immobilization conditions were tested (30, 60 and 90min at 25°C, and 12h at 5°C. For estimating the immobilization rate the amount of the non-adsorbed enzyme on the supports was indirectly determined. When activated carbon was used, no significant difference was observed among the tested conditions, obtaining 100% of enzymatic immobilization. In case of alumina, the best condition showed to be the 90min treatment which produced 37% of immobilization. The evaluation of the degree of exposition of phenylalanine, by second derivative spectrophotometry, was used for the determination of the enzyme operational stability, and showed that the immobilization in activated carbon and in alumina allowed the reusability of the pancreatin for 5 times and 2 times, respectively

  11. What Do Test Scores Really Mean? A Latent Class Analysis of Danish Test Score Performance

    DEFF Research Database (Denmark)

    Munk, Martin D.; McIntosh, James

    2014-01-01

    Latent class Poisson count models are used to analyze a sample of Danish test score results from a cohort of individuals born in 1954-55, tested in 1968, and followed until 2011. The procedure takes account of unobservable effects as well as excessive zeros in the data. We show that the test scores...... of intelligence explain a significant proportion of the variation in test scores. This adds to the complexity of interpreting test scores and suggests that school culture and possible incentive problems make it more di¢ cult to understand what the tests measure....

  12. NCACO-score: An effective main-chain dependent scoring function for structure modeling

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    Dong Xiaoxi

    2011-05-01

    Full Text Available Abstract Background Development of effective scoring functions is a critical component to the success of protein structure modeling. Previously, many efforts have been dedicated to the development of scoring functions. Despite these efforts, development of an effective scoring function that can achieve both good accuracy and fast speed still presents a grand challenge. Results Based on a coarse-grained representation of a protein structure by using only four main-chain atoms: N, Cα, C and O, we develop a knowledge-based scoring function, called NCACO-score, that integrates different structural information to rapidly model protein structure from sequence. In testing on the Decoys'R'Us sets, we found that NCACO-score can effectively recognize native conformers from their decoys. Furthermore, we demonstrate that NCACO-score can effectively guide fragment assembly for protein structure prediction, which has achieved a good performance in building the structure models for hard targets from CASP8 in terms of both accuracy and speed. Conclusions Although NCACO-score is developed based on a coarse-grained model, it is able to discriminate native conformers from decoy conformers with high accuracy. NCACO is a very effective scoring function for structure modeling.

  13. Protein sources and digestive enzyme activities in jundiá (Rhamdia quelen Fontes protéicas e atividade de enzimas digestivas em jundiás (Rhamdia quelen

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    Rafael Lazzari

    2010-01-01

    Full Text Available Digestive enzymes activity influence feed utilization by fish, and its understanding is important to optimize diet formulation. This study reports the digestive enzyme activities of jundiá juveniles fed diets with protein sources. Fish were fed six experimental diets for 90 days: MBY (meat and bone meal + sugar cane yeast, SY (soybean meal + sugar cane yeast, S (soybean meal, MBS (meat and bone meal + soybean meal, FY (fish meal + sugar cane yeast and FS (fish meal + soybean meal, and then sampled every 30 days and assayed in two intestine sections for digestive enzymes - trypsin, chymotrypsin and amylase - activities; gastric protease was assayed in the stomach. Digestive and hepatosomatic index, intestinal quotient, digestive tract length and weight gain were also measured. Trypsin and chymotrypsin activities were higher (p As enzimas digestivas influenciam a utilização dos alimentos em peixes, e seu conhecimento é importante para otimizar a formulação de dietas. Este trabalho descreve a atividade de enzimas digestivas em juvenis de jundiá alimentados com fontes protéicas. Os peixes foram alimentados com seis dietas (90 dias: MBY (farinha de carne e ossos + levedura de cana, SY (farelo de soja + levedura de cana, S (farelo de soja, MBS (farinha de carne e ossos + farelo de soja, FY (farinha de peixe + levedura de cana e FS (farinha de peixe + farelo de soja. A cada 30 dias, foram analisadas as enzimas digestivas (tripsina, quimiotripsina e amilase no intestino. No estômago, foi mensurada a protease ácida. Foram estimados os índices digestivo e hepato-somático, quociente intestinal, comprimento do trato digestório e ganho em peso. As atividades de tripsina e quimiotripsina foram maiores (p < 0,0001 nos peixes alimentados com as dietas com fontes de origem animal (MBY, MBS, FY e FS. As proteases alcalinas foram afetadas negativamente pelo farelo de soja nas dietas. A atividade de amilase apresentou grandes variações. Os peixes

  14. Ativação da proteína TGFbetaI latente em pulmão irradiado in vivo Latent TGFbeta1 activation in the lung irradiated in vivo

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    MARCOS DUARTE MATTOS

    2002-12-01

    Full Text Available OBJETIVO: Investigar no pulmão, por imunohistoquímica, a localização das proteínas TGFbeta1 latente e TGFbeta1 ativa, se ocorre ativação radioinduzida da proteína TGFbeta1 latente e a distribuição das fibras colágenas em diversos períodos de tempo após irradiação. MÉTODOS: 32 camundongos isogênicos (C57BL foram divididos em dois grupos: GI (não irradiado com 12 animais e GII (irradiado com 20 animais. Os animais do GII receberam radiação gama (telecobaltoterapia, 60Co, com rendimento de 0,97Gy/min, dose única de 7Gy em corpo inteiro. Os camundongos dos grupos I e II foram sacrificados por estiramento cervical nos períodos de 1, 14, 30 e 90 dias após irradiação. RESULTADOS: Os pulmões irradiados apresentaram: 1 congestão vascular e espessamento dos septos alveolares aos 30 dias e mais intensamente aos 90 dias depois da irradiação; 2 aumento significante da deposição de colágeno em todos os períodos de tempo após irradiação; 3 fraca ativação da proteína TGFbeta1 latente em um dia e intensa aos 14 dias depois da irradiação em brônquios e alvéolos. Nossos resultados sugerem que células dos brônquios e alvéolos podem participar do complexo mecanismo de fibrose pulmonar radioinduzida atuando como fontes da proteína TGFbeta1 ativa.PURPOSE: assess the latent and active TGFb1 localization in the lung, whether or not radiation induces latent TGFbeta1 activation, and the distribution of collagen fibers in the irradiated lung. METHODS: Thirty two C57BL mice were randomly assigned in two groups: GI (non irradiated animals and GII (irradiated animals. The mice from GII received a single whole ¾ body radiation dose of 7Gy, using a 60Co source at a dose rate of 0.97 Gy/min. They were sacrificed by cervical dislocation at 1, 14, 30 and 90 days after radiation. RESULTS: The irradiated lungs showed: 1 vascular congestion and thickness of the alveolar septa 30 days and more intense 90 days after irradiation; 2

  15. Eficácia terapêutica e segurança de metotrexato + leflunomida em pacientes colombianos com artrite reumatoide ativa refratária ao tratamento convencional Therapeutic efficacy and safety of methotrexate + leflunomide in Colombian patients with active rheumatoid arthritis refractory to conventional treatment

    Directory of Open Access Journals (Sweden)

    John Londono

    2012-12-01

    Full Text Available INTRODUÇÃO: A combinação de metotrexato (MTX + leflunomida (LFN demonstrou ser efetiva no tratamento da artrite reumatoide (AR, mas sua segurança tem sido questionada. OBJETIVO: Avaliar a eficácia e a segurança terapêutica da combinação de MTX + LFN em pacientes com AR ativa. MÉTODOS: Estudo multicêntrico com 24 semanas de duração envolvendo 88 pacientes com doença ativa, apesar do tratamento regular com MTX e prednisolona. RESULTADOS: Participaram do estudo 78 mulheres (88% e 10 homens. A idade foi de 51,3 ± 12,4 anos, e o tempo de evolução da doença, 8,0 ± 6,8 anos. Os pacientes tinham doença ativa evidenciada por IQR média de 10 (7,0-13,0 nas articulações inflamadas e 14,0 (18,0-10,0 nas articulações dolorosas. As respostas ACR obtidas na semana 24 foram: ACR20: 76%; ACR50: 67,1%; e ACR70: 23,9%. Houve melhora na atividade da doença, medida pelo escore DAS-28: 5,8 ± 1,2 no início do estudo vs. 3,8 ± 1,6 na semana 24 (P = 0,000. O evento adverso mais significativo foi elevação das transaminases, ocorrida em oito (26% pacientes. Oito pacientes descontinuaram o estudo devido a eventos adversos: quatro por elevação das transaminases, um por diabetes insípido, um por erupção cutânea, um por diabetes mellitus e um por dor osteomuscular. CONCLUSÃO: A combinação de MTX + LFN é efetiva para o tratamento de AR em pacientes que não obtiveram sucesso com o tratamento convencional. Há necessidade de rígido controle médico e laboratorial para segurança terapêutica.INTRODUCTION: The combination of methotrexate (MTX + leflunomide (LFN has been shown to be effective in the treatment of RA. Its safety has been questioned. OBJECTIVE: To evaluate the effectiveness and safety of the combination of MTX + LFN in patients with active RA. METHODS: This was a 24-week multicenter study, which included 88 patients with active disease despite consistent treatment with methotrexate and prednisolone. RESULTS: We included 78

  16. Nutrient input on rocket growth and soil microbial activity in alley cropping of pigeon pea Aporte de nutrientes em rúcula e atividade microbiana do solo em cultivo com aléias de guandu

    Directory of Open Access Journals (Sweden)

    Márcio Sampaio Pimentel

    2012-03-01

    Full Text Available The effects of organic fertilization combining cattle manure and pigeon pea shoots on the culture of rocket, planted with one or two plants per hole, including soil microbial biomass carbon, soil respiration, the metabolic quotient, soil fumigation labile carbon, and the dry matter content and total N, K, P, Ca and Mg contents in the leaves and roots of rocket were investigated. The experimental design was randomized blocks in a 2 × 2 × 2 factorial experiment: 0 and 160 kg ha-1 N from cattle manure, 0 and 160 kg ha-1 N from pigeon pea shoots, and one or two plants per hole, with three replicates. The most significant and positive correlations were obtained between leaf K × soil respiration, microbial biomass × leaf N and root Ca × metabolic quotient. The use of 160 kg ha-1 N from cattle manure along with 160 kg ha-1 N from pigeon pea shoots with two plants per hole resulted in a lower relative loss of C-CO2; the same result was found for the treatment of two plants per hole fertilized with 160 kg ha-1 N from cattle manure. Increased leaf and root N contents were observed in the treatment that combined two plants in each plot, fertilized with 160 kg ha-1 N from pigeon pea shoots, whereas the highest dry matter content was obtained by using one plant per hole, specifically: combining one plant per hole without fertilization; one plant per hole fertilized with 160 kg ha-1 N from pigeon pea shoots; and one plant per hole fertilized with 160 kg ha-1 N from cattle manure and pigeon pea shoots.Investigou-se o efeito da adubação orgânica combinando esterco bovino, ramas de guandu e densidade populacional por cova na cultura da rúcula sobre carbono da biomassa microbiana do solo, respiração do solo, quociente metabólico, carbono lábil de solo fumigado, teor de matéria seca e conteúdo de N-total, K, P, Ca e Mg foliar e radicular de rúcula. O delineamento experimental adotado foi blocos ao acaso em ensaio fatorial 2 x 2 x 2 e três repeti

  17. A lumbar disc surgery predictive score card.

    Science.gov (United States)

    Finneson, B E

    1978-06-01

    A lumbar disc surgery predictive score card or questionnaire has been developed to assess potential candidates for excision of a herniated lumbar disc who have not previously undergone lumbar spine surgery. It is not designed to encompass patients who are being considered for other types of lumbar spine surgery, such as decompressive laminectomy or fusion. In an effort to make the "score card" usable by almost all physicians who are involved in lumbar disc surgery, only studies which have broad acceptance and are generally employed are included. Studies which have less widespread use such as electromyogram, discogram, venogram, special psychologic studies (MMPI, pain drawings) have been purposely excluded.

  18. Dermatoses em renais cronicos em terapia dialitica

    Directory of Open Access Journals (Sweden)

    Luis Alberto Batista Peres

    2014-03-01

    Full Text Available Objetivo: As desordens cutâneas e das mucosas são comuns em pacientes em hemodiálise a longo prazo. A diálise prolonga a expectativa de vida, dando tempo para a manifestação destas anormalidades. Os objetivos deste estudo foram avaliar a prevalência de problemas dermatológicos em pacientes com doença renal crônica (DRC em hemodiálise. Métodos: Cento e quarenta e cinco pacientes com doença renal crônica em hemodiálise foram estudados. Todos os pacientes foram completamente analisados para as alterações cutâneas, de cabelos, mucosas e unhas por um único examinador e foram coletados dados de exames laboratoriais. Os dados foram armazenados em um banco de dados do Microsolft Excel e analisados por estatística descritiva. As variáveis contínuas foram comparadas pelo teste t de Student e as variáveis categóricas utilizando o teste do qui-quadrado ou o teste Exato de Fischer, conforme adequado. Resultados: O estudo incluiu 145 pacientes, com idade média de 53,6 ± 14,7 anos, predominantemente do sexo masculino (64,1% e caucasianos (90,0%. O tempo médio de diálise foi de 43,3 ± 42,3 meses. As principais doenças subjacentes foram: hipertensão arterial em 33,8%, diabetes mellitus em 29,6% e glomerulonefrite crônica em 13,1%. As principais manifestações dermatológicas observadas foram: xerose em 109 (75,2%, equimose em 87 (60,0%, prurido em 78 (53,8% e lentigo em 33 (22,8% pacientes. Conclusão: O nosso estudo mostrou a presença de mais do que uma dermatose por paciente. As alterações cutâneas são frequentes em pacientes em diálise. Mais estudos são necessários para melhor caracterização e manejo destas dermatoses.

  19. Atividade da enzima acetil-hidrolase do fator ativador de plaquetas (PAF-AH em pacientes com diabete melito tipo 1 Platelet-activating factor acetylhydrolase (PAF-AH activity in patients with type 1 diabetes mellitus

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    Simone Henriques de Castro

    2007-02-01

    Full Text Available OBJETIVO: Avaliar a atividade da acetil-hidrolase do fator ativador de plaquetas (PAF-AH e sua relação com variáveis clinicodemográficas, com o controle metabólico, os níveis de apolipoproteínas A e B e a suscetibilidade da lipoproteína de baixa densidade (LDL à oxidação in vitro em pacientes com DM tipo 1 (DM 1. MÉTODOS: Foram avaliados 42 pacientes com DM1 (27 mulheres e 48 não-diabéticos (16 mulheres, pareados por sexo, idade e índice de massa corporal (IMC. Os exames realizados foram: glicemia de jejum (GJ e pós-prandial (GPP, lipidograma, ácido úrico (AU, hemoglobina glicosilada (HbA1c e coeficiente de oxidação da lipoproteína de baixa densidade (LDL por espectrofotometria. A análise da atividade da PAF-AH foi realizada por espectrofotometria (Cayman Chemical. RESULTADOS: A análise da atividade da PAF-AH mostrou haver maior atividade enzimática nos pacientes com DM 1 do que nos não-diabéticos (0,0150 ± 0,0051 versus 0,0116 ± 0,0041; p OBJECTIVE: To evaluate platelet-activating factor acetylhydrolase (PAF-AH activity and its relationship with clinical and demographic variables, metabolic control, apolipoprotein A and B levels and the susceptibility of low-density lipoprotein