WorldWideScience

Sample records for active length verification

  1. Active Thermal Control Experiments for LISA Ground Verification Testing

    Science.gov (United States)

    Higuchi, Sei; DeBra, Daniel B.

    2006-11-01

    The primary mission goal of LISA is detecting gravitational waves. LISA uses laser metrology to measure the distance between proof masses in three identical spacecrafts. The total acceleration disturbance to each proof mass is required to be below 3 × 10-15 m/s2√Hz . Optical path length variations on each optical bench must be kept below 40 pm/√Hz over 1 Hz to 0.1 mHz. Thermal variations due to, for example, solar radiation or temperature gradients across the proof mass housing will distort the spacecraft causing changes in the mass attraction and sensor location. We have developed a thermal control system developed for the LISA gravitational reference sensor (GRS) ground verification testing which provides thermal stability better than 1 mK/√Hz to f control for the LISA spacecraft to compensate solar irradiation. Thermally stable environment is very demanded for LISA performance verification. In a lab environment specifications can be met with considerable amount of insulation and thermal mass. For spacecraft, the very limited thermal mass calls for an active control system which can meet disturbance rejection and stability requirements simultaneously in the presence of long time delay. A simple proportional plus integral control law presently provides approximately 1 mK/√Hz of thermal stability for over 80 hours. Continuing development of a model predictive feed-forward algorithm will extend performance to below 1 mK/√Hz at f < 1 mHz and lower.

  2. 76 FR 44088 - Agency Information Collection (Eligibility Verification Reports) Activity Under OMB Review

    Science.gov (United States)

    2011-07-22

    ... AFFAIRS Agency Information Collection (Eligibility Verification Reports) Activity Under OMB Review AGENCY... INFORMATION: Titles: Eligibility Verification Reports (EVR). a. Eligibility Verification Report Instructions... information abstracted below to the Office of Management and Budget (OMB) for review and comment. The PRA...

  3. 75 FR 60169 - Proposed Information Collection (Vetbiz Vendor Information Pages Verification Program) Activity...

    Science.gov (United States)

    2010-09-29

    ... AFFAIRS Proposed Information Collection (Vetbiz Vendor Information Pages Verification Program) Activity... use of other forms of information technology. Title: Vetbiz Vendor Information Pages Verification... collection. Abstract: Vetbiz Vendor Information Pages Verification Program is used to assist federal agencies...

  4. Formal Verification of Effectiveness of Control Activities in Business Processes

    Science.gov (United States)

    Arimoto, Yasuhito; Iida, Shusaku; Futatsugi, Kokichi

    It has been an important issue to deal with risks in business processes for achieving companies' goals. This paper introduces a method for applying a formal method to analysis of risks and control activities in business processes in order to evaluate control activities consistently, exhaustively, and to give us potential to have scientific discussion on the result of the evaluation. We focus on document flows in business activities and control activities and risks related to documents because documents play important roles in business. In our method, document flows including control activities are modeled and it is verified by OTS/CafeOBJ Method that risks about falsification of documents are avoided by control activities in the model. The verification is done by interaction between humans and CafeOBJ system with theorem proving, and it raises potential to discuss the result scientifically because the interaction gives us rigorous reasons why the result is derived from the verification.

  5. 77 FR 60714 - Information Collection Activities: Legacy Data Verification Process (LDVP); Submitted for Office...

    Science.gov (United States)

    2012-10-04

    ... the information. The subject of this information collection request is the ``Legacy Data Verification... Bureau of Safety and Environmental Enforcement Information Collection Activities: Legacy Data Verification Process (LDVP); Submitted for Office of Management and Budget (OMB) Review; Comment Request ACTION...

  6. 75 FR 78806 - Agency Information Collection (Residency Verification Report-Veterans and Survivors) Activity...

    Science.gov (United States)

    2010-12-16

    ... AFFAIRS Agency Information Collection (Residency Verification Report-- Veterans and Survivors) Activity.... 2900-0655.'' SUPPLEMENTARY INFORMATION: Title: Residency Verification Report--Veterans and Survivors... submit the collection of information abstracted below to the Office of Management and Budget (OMB) for...

  7. Experimental Verification of Comparability between Spin-Orbit and Spin-Diffusion Lengths

    OpenAIRE

    Niimi, Yasuhiro; Wei, Dahai; Idzuchi, Hiroshi; Wakamura, Taro; Kato, Takeo; Otani, YoshiChika

    2012-01-01

    We experimentally confirmed that the spin-orbit lengths of noble metals obtained from weak anti-localization measurements are comparable to the spin diffusion lengths determined from lateral spin valve ones. Even for metals with strong spin-orbit interactions such as Pt, we verified that the two methods gave comparable values which were much larger than those obtained from recent spin torque ferromagnetic resonance measurements. To give a further evidence for the comparability between the two...

  8. Relationship between physical activity level, telomere length, and telomerase activity.

    Science.gov (United States)

    Ludlow, Andrew T; Zimmerman, Jo B; Witkowski, Sarah; Hearn, Joe W; Hatfield, Bradley D; Roth, Stephen M

    2008-10-01

    The purpose of this study was to examine the relationship of exercise energy expenditure (EEE) with both telomere length and telomerase activity in addition to accounting for hTERT C-1327T promoter genotype. Sixty-nine (n = 34 males; n = 35 females) participants 50-70 yr were assessed for weekly EEE level using the Yale Physical Activity Survey. Lifetime consistency of EEE was also determined. Subjects were recruited across a large range of EEE levels and separated into quartiles: 0-990, 991-2340, 2341-3540, and >3541 kcal x wk(-1). Relative telomere length and telomerase activity were measured in peripheral blood mononuclear cells (PBMC). The second EEE quartile exhibited significantly longer telomere lengths [1.12 +/- 0.03 relative units (RU)] than both the first and fourth EEE quartiles (0.94 +/- 0.03 and 0.96 +/- 0.03 RU, respectively; P EEE quartiles. An association was observed between telomerase enzyme activity and hTERT genotype with the TT genotype (1.0 x 10(-2) +/- 4.0 x 10(-3) attomoles (amol) per 10,000 cells; n = 19) having significantly greater telomerase enzyme activity than both the CT (1.3 x 10(-3) +/- 3.2 x 10(-3); n = 30) and CC groups (5.0 x 10(-4) +/- 3.9 x 10(-3); n = 20; P = 0.01). These results indicate that moderate physical activity levels may provide a protective effect on PBMC telomere length compared with both low and high EEE levels.

  9. Length dependence of active force production in skeletal muscle.

    Science.gov (United States)

    Rassier, D E; MacIntosh, B R; Herzog, W

    1999-05-01

    The sliding filament and cross-bridge theories of muscle contraction provide discrete predictions of the tetanic force-length relationship of skeletal muscle that have been tested experimentally. The active force generated by a maximally activated single fiber (with sarcomere length control) is maximal when the filament overlap is optimized and is proportionally decreased when overlap is diminished. The force-length relationship is a static property of skeletal muscle and, therefore, it does not predict the consequences of dynamic contractions. Changes in sarcomere length during muscle contraction result in modulation of the active force that is not necessarily predicted by the cross-bridge theory. The results of in vivo studies of the force-length relationship suggest that muscles that operate on the ascending limb of the force-length relationship typically function in stretch-shortening cycle contractions, and muscles that operate on the descending limb typically function in shorten-stretch cycle contractions. The joint moments produced by a muscle depend on the moment arm and the sarcomere length of the muscle. Moment arm magnitude also affects the excursion (length change) of a muscle for a given change in joint angle, and the number of sarcomeres arranged in series within a muscle fiber determines the sarcomere length change associated with a given excursion.

  10. 78 FR 6852 - Agency Information Collection (Student Verification of Enrollment) Activity Under OMB Review

    Science.gov (United States)

    2013-01-31

    ... AFFAIRS Agency Information Collection (Student Verification of Enrollment) Activity Under OMB Review....'' SUPPLEMENTARY INFORMATION: Title: Student Verification of Enrollment, VA Form 22-8979. OMB Control Number: 2900... of information abstracted below to the Office of Management and Budget (OMB) for review and comment...

  11. 77 FR 325 - Agency Information Collection (Accelerated Payment Verification of Completion Letter): Activity...

    Science.gov (United States)

    2012-01-04

    ... AFFAIRS Agency Information Collection (Accelerated Payment Verification of Completion Letter): Activity... INFORMATION: Title: Accelerated Payment Verification of Completion Letter, VA Form 22-0840. OMB Control Number... collection of information abstracted below to the Office of Management and Budget (OMB) for review and...

  12. 77 FR 64596 - Proposed Information Collection (Income Verification) Activity: Comment Request

    Science.gov (United States)

    2012-10-22

    ... AFFAIRS Proposed Information Collection (Income Verification) Activity: Comment Request AGENCY: Veterans... techniques or the use of other forms of information technology. Title: Income Verification, VA Form 21-0161a... proposed collection of certain information by the agency. Under the Paperwork Reduction Act (PRA) of 1995...

  13. 75 FR 3541 - Agency Information Collection (Verification of VA Benefits) Activity Under OMB Review

    Science.gov (United States)

    2010-01-21

    ... AFFAIRS Agency Information Collection (Verification of VA Benefits) Activity Under OMB Review AGENCY... INFORMATION: Title: Verification of VA Benefits, VA Form 26-8937. OMB Control Number: 2900-0406. Type of... Veterans Benefits Administration, Department of Veterans Affairs will submit the collection of information...

  14. 78 FR 46424 - Proposed Information Collection (Residency Verification Report-Veterans and Survivors) Activity...

    Science.gov (United States)

    2013-07-31

    ... AFFAIRS Proposed Information Collection (Residency Verification Report-- Veterans and Survivors) Activity... techniques or the use of other forms of information technology. Title: Residency Verification Report... opportunity for public comment on the proposed collection of certain information by the agency. Under the...

  15. 75 FR 76080 - Agency Information Collection (VetBiz Vendor Information Pages Verification Program) Activity...

    Science.gov (United States)

    2010-12-07

    ... AFFAIRS Agency Information Collection (VetBiz Vendor Information Pages Verification Program) Activity... Information Pages Verification Program, VA Form 0877. OMB Control Number: 2900-0675. Type of Review: Extension...), Department of Veterans Affairs, will submit the collection of information abstracted below to the Office of...

  16. 77 FR 64383 - Proposed Information Collection (Verification of VA Benefits) Activity: Comment Request

    Science.gov (United States)

    2012-10-19

    ... AFFAIRS Proposed Information Collection (Verification of VA Benefits) Activity: Comment Request AGENCY... techniques or the use of other forms of information technology. Title: Verification of VA Benefits, VA Form... comment on the proposed collection of certain information by the agency. Under the Paperwork Reduction Act...

  17. 75 FR 62186 - Proposed Information Collection (Residency Verification Report-Veterans and Survivors) Activity...

    Science.gov (United States)

    2010-10-07

    ... AFFAIRS Proposed Information Collection (Residency Verification Report-- Veterans and Survivors) Activity... techniques or the use of other forms of information technology. Title: Residency Verification Report... opportunity for public comment on the proposed collection of certain information by the agency. Under the...

  18. 78 FR 6849 - Agency Information Collection (Verification of VA Benefits) Activity Under OMB Review

    Science.gov (United States)

    2013-01-31

    ... AFFAIRS Agency Information Collection (Verification of VA Benefits) Activity Under OMB Review AGENCY....gov . Please refer to ``OMB Control No. 2900-0406.'' SUPPLEMENTARY INFORMATION: Title: Verification of... Veterans Benefits Administration, Department of Veterans Affairs will submit the collection of information...

  19. 78 FR 76411 - Agency Information Collection (Residency Verification Report-Veterans and Survivors) Activity...

    Science.gov (United States)

    2013-12-17

    ... AFFAIRS Agency Information Collection (Residency Verification Report-- Veterans and Survivors) Activity... . Please refer to ``OMB Control No. 2900-0655.'' SUPPLEMENTARY INFORMATION: Title: Residency Verification... submit the collection of information abstracted below to the Office of Management and Budget (OMB) for...

  20. Correlation lengths in hydrodynamic models of active nematics.

    Science.gov (United States)

    Hemingway, Ewan J; Mishra, Prashant; Marchetti, M Cristina; Fielding, Suzanne M

    2016-09-28

    We examine the scaling with activity of the emergent length scales that control the nonequilibrium dynamics of an active nematic liquid crystal, using two popular hydrodynamic models that have been employed in previous studies. In both models we find that the chaotic spatio-temporal dynamics in the regime of fully developed active turbulence is controlled by a single active scale determined by the balance of active and elastic stresses, regardless of whether the active stress is extensile or contractile in nature. The observed scaling of the kinetic energy and enstrophy with activity is consistent with our single-length scale argument and simple dimensional analysis. Our results provide a unified understanding of apparent discrepancies in the previous literature and demonstrate that the essential physics is robust to the choice of model.

  1. QKD system with fast active optical path length compensation

    Science.gov (United States)

    Park, Byung Kwon; Lee, Min Soo; Woo, Min Ki; Kim, Yong-Su; Han, Sang-Wook; Moon, Sung

    2017-06-01

    We develop a quantum key distribution (QKD) system with fast active optical path length compensation. A rapid and reliable active optical path length compensation scheme is proposed and applied to a plug-and-play QKD system. The system monitors changes in key rates and controls it is own operation automatically. The system achieves its optimal performance within three seconds of operation, which includes a sifted key rate of 5.5 kbps and a quantum bit error rate of less than 2% after an abrupt temperature variation along the 25 km quantum channel. The system also operates well over a 24 h period while completing more than 60 active optical path length compensations.

  2. 76 FR 60132 - Proposed Information Collection (Accelerated Payment Verification of Completion Letter) Activity...

    Science.gov (United States)

    2011-09-28

    ... AFFAIRS Proposed Information Collection (Accelerated Payment Verification of Completion Letter) Activity... opportunity for public comment on the proposed collection of certain information by the agency. Under the... Register concerning each proposed collection of information, including each proposed extension of currently...

  3. 77 FR 67737 - Proposed Information Collection (Student Verification of Enrollment) Activity: Comment Request

    Science.gov (United States)

    2012-11-13

    ... AFFAIRS Proposed Information Collection (Student Verification of Enrollment) Activity: Comment Request... for public comment on the proposed collection of certain information by the agency. Under the... Register concerning each proposed collection of information, including each proposed extension of a...

  4. 77 FR 55486 - Agency Information Collection Activities: Employment Eligibility Verification, Form I-9, OMB...

    Science.gov (United States)

    2012-09-10

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Employment Eligibility Verification, Form I-9, OMB Control No. 1615-0047; Correction ACTION: 30-Day Notice of Information... and Immigration Services (USCIS) published a 30-day Notice of Information Collection Under Review (30...

  5. 78 FR 6852 - Agency Information Collection (Income Verification) Activity Under OMB Review

    Science.gov (United States)

    2013-01-31

    ... AFFAIRS Agency Information Collection (Income Verification) Activity Under OMB Review AGENCY: Veterans... Benefits Administration (VBA), Department of Veterans Affairs, will submit the collection of information... describes the nature of the information collection and its expected cost and burden; it includes the actual...

  6. 77 FR 56856 - Agency Information Collection Activities: Employment Eligibility Verification, Form I-9, OMB...

    Science.gov (United States)

    2012-09-14

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Employment Eligibility Verification, Form I-9, OMB Control No. 1615-0047; Correction ACTION: 30-Day Notice Correction... published to allow for a 30-day public comment period on the proposed revisions to the information...

  7. 77 FR 50710 - Agency Information Collection Activities: Employment Eligibility Verification, Form I-9, OMB...

    Science.gov (United States)

    2012-08-22

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Employment Eligibility Verification, Form I-9, OMB Control No. 1615-0047; Revision of an Existing Information Collection, Comment Request ACTION: 30-Day Notice of Information Collection Under Review: Employment Eligibility...

  8. 77 FR 20889 - Proposed Information Collection (Request One-VA Identification Verification Card) Activity...

    Science.gov (United States)

    2012-04-06

    ... AFFAIRS Proposed Information Collection (Request One-VA Identification Verification Card) Activity... certain information by the agency. Under the Paperwork Reduction Act (PRA) of 1995, Federal agencies are required to publish notice in the Federal Register concerning each proposed collection of information...

  9. 77 FR 38396 - Agency Information Collection (One-VA Identification Verification Card) Activities Under OMB Review

    Science.gov (United States)

    2012-06-27

    ... AFFAIRS Agency Information Collection (One-VA Identification Verification Card) Activities Under OMB... Affairs, will submit the collection of information abstracted below to the Office of Management and Budget (OMB) for review and comment. The PRA submission describes the nature of the information collection and...

  10. Active-passive path-length encoded (APPLE) Doppler OCT.

    Science.gov (United States)

    Wartak, Andreas; Haindl, Richard; Trasischker, Wolfgang; Baumann, Bernhard; Pircher, Michael; Hitzenberger, Christoph K

    2016-12-01

    We present a novel active-passive path-length encoded (APPLE) swept source Doppler optical coherence tomography (DOCT) approach, enabling three-dimensional velocity vector reconstruction of moving particles without prior knowledge of the orientation of motion. The developed APPLE DOCT setup allows for non-invasive blood flow measurements in vivo and was primarily designed for quantitative human ocular blood flow investigations. The system's performance was demonstrated by in vitro flow phantom as well as in vivo retinal vessel bifurcation measurements. Furthermore, total retinal blood flow - a biomarker aiding in diagnosis and monitoring of major ocular diseases such as glaucoma, diabetic retinopathy or central/branch retinal vein occlusion - was determined in the eyes of healthy human volunteers.

  11. First Exon Length Controls Active Chromatin Signatures and Transcription

    Directory of Open Access Journals (Sweden)

    Nicole I. Bieberstein

    2012-07-01

    Full Text Available Here, we explore the role of splicing in transcription, employing both genome-wide analysis of human ChIP-seq data and experimental manipulation of exon-intron organization in transgenic cell lines. We show that the activating histone modifications H3K4me3 and H3K9ac map specifically to first exon-intron boundaries. This is surprising, because these marks help recruit general transcription factors (GTFs to promoters. In genes with long first exons, promoter-proximal levels of H3K4me3 and H3K9ac are greatly reduced; consequently, GTFs and RNA polymerase II are low at transcription start sites (TSSs and exhibit a second, promoter-distal peak from which transcription also initiates. In contrast, short first exons lead to increased H3K4me3 and H3K9ac at promoters, higher expression levels, accuracy in TSS usage, and a lower frequency of antisense transcription. Therefore, first exon length is predictive for gene activity. Finally, splicing inhibition and intron deletion reduce H3K4me3 levels and transcriptional output. Thus, gene architecture and splicing determines transcription quantity and quality as well as chromatin signatures.

  12. Verification and disarmament

    Energy Technology Data Exchange (ETDEWEB)

    Blix, H. [IAEA, Vienna (Austria)

    1998-07-01

    The main features are described of the IAEA safeguards verification system that non-nuclear weapon states parties of the NPT are obliged to accept. Verification activities/problems in Iraq and North Korea are discussed.

  13. Modelling and Verification of Web Services Business Activity Protocol

    DEFF Research Database (Denmark)

    Ravn, Anders Peter; Srba, Jiri; Vighio, Saleem

    2011-01-01

    WS-Business Activity specification defines two coordination protocols in order to ensure a consistent agreement on the outcome of long-running distributed applications. We use the model checker Uppaal to analyse the Business Agreement with Coordination Completion protocol type. Our analyses show...

  14. One-Quarter-Car Active SuspensionModel Verification

    Directory of Open Access Journals (Sweden)

    Hyniova Katerina

    2017-01-01

    Full Text Available Suspension system influences both the comfort and safety of the passengers. In the paper, energy recuperation and management in automotive suspension systems with linear electric motors that are controlled by a designed H∞ controller to generate a variable mechanical force for a car damper is presented. Vehicle shock absorbers in which forces are generated in response to feedback signals by active elements obviously offer increased design flexibility compared to the conventional suspensions with passive elements (springs and dampers. The main advantage of the proposed solution that uses a linear AC motor is the possibility to generate desired forces acting between the unsprung (wheel and sprung (one-quarter of the car body mass masses of the car, providing good insulation of the car sprung mass from the road surface roughness and load disturbances. As shown in the paper, under certain circumstances linear motors as actuators enable to transform mechanical energy of the vertical car vibrations to electrical energy, accumulate it, and use it when needed. Energy flow control enables to reduce or even eliminate the demands on the external power source. In particular, the paper is focused on experiments with active shock absorber that has been taken on the designed test bed and the way we developed an appropriate input signal for the test bed that as real road disturbance acts upon the vibration absorber and the obtained results are evaluated at the end. Another important point the active suspension design should satisfy is energy supply control that is made via standard controller modification, and which allows changing amount of energy required by the system. Functionality of the designed controller modification was verified taking various experiments on the experiment stand as mentioned in the paper.

  15. Feasibility of proton-activated implantable markers for proton range verification using PET

    Science.gov (United States)

    Cho, Jongmin; Ibbott, Geoffrey; Gillin, Michael; Gonzalez-Lepera, Carlos; Titt, Uwe; Paganetti, Harald; Kerr, Matthew; Mawlawi, Osama

    2013-11-01

    Proton beam range verification using positron emission tomography (PET) currently relies on proton activation of tissue, the products of which decay with a short half-life and necessitate an on-site PET scanner. Tissue activation is, however, negligible near the distal dose fall-off region of the proton beam range due to their high interaction energy thresholds. Therefore Monte Carlo simulation is often supplemented for comparison with measurement; however, this also may be associated with systematic and statistical uncertainties. Therefore, we sought to test the feasibility of using long-lived proton-activated external materials that are inserted or infused into the target volume for more accurate proton beam range verification that could be performed at an off-site PET scanner. We irradiated samples of ≥98% 18O-enriched water, natural Cu foils, and >97% 68Zn-enriched foils as candidate materials, along with samples of tissue-equivalent materials including 16O water, heptane (C7H16), and polycarbonate (C16H14O3)n, at four depths (ranging from 100% to 3% of center of modulation (COM) dose) along the distal fall-off of a modulated 160 MeV proton beam. Samples were irradiated either directly or after being embedded in Plastic Water® or balsa wood. We then measured the activity of the samples using PET imaging for 20 or 30 min after various delay times. Measured activities of candidate materials were up to 100 times greater than those of the tissue-equivalent materials at the four distal dose fall-off depths. The differences between candidate materials and tissue-equivalent materials became more apparent after longer delays between irradiation and PET imaging, due to the longer half-lives of the candidate materials. Furthermore, the activation of the candidate materials closely mimicked the distal dose fall-off with offsets of 1 to 2 mm. Also, signals from the foils were clearly visible compared to the background from the activated Plastic Water® and balsa wood

  16. Verification of cardiac mechanics software: benchmark problems and solutions for testing active and passive material behaviour.

    Science.gov (United States)

    Land, Sander; Gurev, Viatcheslav; Arens, Sander; Augustin, Christoph M; Baron, Lukas; Blake, Robert; Bradley, Chris; Castro, Sebastian; Crozier, Andrew; Favino, Marco; Fastl, Thomas E; Fritz, Thomas; Gao, Hao; Gizzi, Alessio; Griffith, Boyce E; Hurtado, Daniel E; Krause, Rolf; Luo, Xiaoyu; Nash, Martyn P; Pezzuto, Simone; Plank, Gernot; Rossi, Simone; Ruprecht, Daniel; Seemann, Gunnar; Smith, Nicolas P; Sundnes, Joakim; Rice, J Jeremy; Trayanova, Natalia; Wang, Dafang; Jenny Wang, Zhinuo; Niederer, Steven A

    2015-12-08

    Models of cardiac mechanics are increasingly used to investigate cardiac physiology. These models are characterized by a high level of complexity, including the particular anisotropic material properties of biological tissue and the actively contracting material. A large number of independent simulation codes have been developed, but a consistent way of verifying the accuracy and replicability of simulations is lacking. To aid in the verification of current and future cardiac mechanics solvers, this study provides three benchmark problems for cardiac mechanics. These benchmark problems test the ability to accurately simulate pressure-type forces that depend on the deformed objects geometry, anisotropic and spatially varying material properties similar to those seen in the left ventricle and active contractile forces. The benchmark was solved by 11 different groups to generate consensus solutions, with typical differences in higher-resolution solutions at approximately 0.5%, and consistent results between linear, quadratic and cubic finite elements as well as different approaches to simulating incompressible materials. Online tools and solutions are made available to allow these tests to be effectively used in verification of future cardiac mechanics software.

  17. A Visual Analytics Approach to Structured Data Analysis to Enhance Nonproliferation and Arms Control Verification Activities

    Energy Technology Data Exchange (ETDEWEB)

    Gillen, David S.

    2014-08-07

    Analysis activities for Nonproliferation and Arms Control verification require the use of many types of data. Tabular structured data, such as Excel spreadsheets and relational databases, have traditionally been used for data mining activities, where specific queries are issued against data to look for matching results. The application of visual analytics tools to structured data enables further exploration of datasets to promote discovery of previously unknown results. This paper discusses the application of a specific visual analytics tool to datasets related to the field of Arms Control and Nonproliferation to promote the use of visual analytics more broadly in this domain. Visual analytics focuses on analytical reasoning facilitated by interactive visual interfaces (Wong and Thomas 2004). It promotes exploratory analysis of data, and complements data mining technologies where known patterns can be mined for. Also with a human in the loop, they can bring in domain knowledge and subject matter expertise. Visual analytics has not widely been applied to this domain. In this paper, we will focus on one type of data: structured data, and show the results of applying a specific visual analytics tool to answer questions in the Arms Control and Nonproliferation domain. We chose to use the T.Rex tool, a visual analytics tool developed at PNNL, which uses a variety of visual exploration patterns to discover relationships in structured datasets, including a facet view, graph view, matrix view, and timeline view. The facet view enables discovery of relationships between categorical information, such as countries and locations. The graph tool visualizes node-link relationship patterns, such as the flow of materials being shipped between parties. The matrix visualization shows highly correlated categories of information. The timeline view shows temporal patterns in data. In this paper, we will use T.Rex with two different datasets to demonstrate how interactive exploration of

  18. Active Mirror Predictive and Requirements Verification Software (AMP-ReVS)

    Science.gov (United States)

    Basinger, Scott A.

    2012-01-01

    This software is designed to predict large active mirror performance at various stages in the fabrication lifecycle of the mirror. It was developed for 1-meter class powered mirrors for astronomical purposes, but is extensible to other geometries. The package accepts finite element model (FEM) inputs and laboratory measured data for large optical-quality mirrors with active figure control. It computes phenomenological contributions to the surface figure error using several built-in optimization techniques. These phenomena include stresses induced in the mirror by the manufacturing process and the support structure, the test procedure, high spatial frequency errors introduced by the polishing process, and other process-dependent deleterious effects due to light-weighting of the mirror. Then, depending on the maturity of the mirror, it either predicts the best surface figure error that the mirror will attain, or it verifies that the requirements for the error sources have been met once the best surface figure error has been measured. The unique feature of this software is that it ties together physical phenomenology with wavefront sensing and control techniques and various optimization methods including convex optimization, Kalman filtering, and quadratic programming to both generate predictive models and to do requirements verification. This software combines three distinct disciplines: wavefront control, predictive models based on FEM, and requirements verification using measured data in a robust, reusable code that is applicable to any large optics for ground and space telescopes. The software also includes state-of-the-art wavefront control algorithms that allow closed-loop performance to be computed. It allows for quantitative trade studies to be performed for optical systems engineering, including computing the best surface figure error under various testing and operating conditions. After the mirror manufacturing process and testing have been completed, the

  19. Active stabilization of a fiber-optic two-photon interferometer using continuous optical length control

    National Research Council Canada - National Science Library

    Cho, Seok-Beom; Kim, Heonoh

    2016-01-01

    ... 6-km-long fiber-optic Hong-Ou-Mandel interferometer. The two-step active control techniques are applied for measuring highly stable two-photon interference fringes by scanning the optical path-length difference...

  20. Statistical analysis and verification of 3-hourly geomagnetic activity probability predictions

    Science.gov (United States)

    Wang, Jingjing; Zhong, Qiuzhen; Liu, Siqing; Miao, Juan; Liu, Fanghua; Li, Zhitao; Tang, Weiwei

    2015-12-01

    The Space Environment Prediction Center (SEPC) has classified geomagnetic activity into four levels: quiet to unsettled (Kp 6). The 3-hourly Kp index prediction product provided by the SEPC is updated half hourly. In this study, the statistical conditional forecast models for the 3-hourly geomagnetic activity level were developed based on 10 years of data and applied to more than 3 years of data, using the previous Kp index, interplanetary magnetic field, and solar wind parameters measured by the Advanced Composition Explorer as conditional parameters. The quality of the forecast models was measured and compared against verifications of accuracy, reliability, discrimination capability, and skill of predicting all geomagnetic activity levels, especially the probability of reaching the storm level given a previous "calm" (nonstorm level) or "storm" (storm level) condition. It was found that the conditional models that used the previous Kp index, the peak value of BtV (the product of the total interplanetary magnetic field and speed), the average value of Bz (the southerly component of the interplanetary magnetic field), and BzV (the product of the southerly component of the interplanetary magnetic field and speed) over the last 6 h as conditional parameters provide a relative operating characteristic area of 0.64 and can be an appropriate predictor for the probability forecast of geomagnetic activity level.

  1. Active stabilization of a fiber-optic two-photon interferometer using continuous optical length control.

    Science.gov (United States)

    Cho, Seok-Beom; Kim, Heonoh

    2016-05-16

    The practical realization of long-distance entanglement-based quantum communication systems strongly rely on the observation of highly stable quantum interference between correlated single photons. This task must accompany active stabilization of the optical path lengths within the single-photon coherence length. Here, we provide two-step interferometer stabilization methods employing continuous optical length control and experimentally demonstrate two-photon quantum interference using an actively stabilized 6-km-long fiber-optic Hong-Ou-Mandel interferometer. The two-step active control techniques are applied for measuring highly stable two-photon interference fringes by scanning the optical path-length difference. The obtained two-photon interference visibilities with and without accidental subtraction are found to be approximately 90.7% and 65.4%, respectively.

  2. Verification of relationships between anthropometric variables among ureteral stents recipients and ureteric lengths: a challenge for Vitruvian-da Vinci theory.

    Science.gov (United States)

    Acelam, Philip A

    2015-01-01

    To determine and verify how anthropometric variables correlate to ureteric lengths and how well statistical models approximate the actual ureteric lengths. In this work, 129 charts of endourological patients (71 females and 58 males) were studied retrospectively. Data were gathered from various research centers from North and South America. Continuous data were studied using descriptive statistics. Anthropometric variables (age, body surface area, body weight, obesity, and stature) were utilized as predictors of ureteric lengths. Linear regressions and correlations were used for studying relationships between the predictors and the outcome variables (ureteric lengths); P-value was set at 0.05. To assess how well statistical models were capable of predicting the actual ureteric lengths, percentages (or ratios of matched to mismatched results) were employed. The results of the study show that anthropometric variables do not correlate well to ureteric lengths. Statistical models can partially estimate ureteric lengths. Out of the five anthropometric variables studied, three of them: body frame, stature, and weight, each with a Pvariables: age (R (2)=0.01; P=0.20) and obesity (R (2)=0.03; P=0.06), were found to be poor estimators of ureteric lengths. None of the predictors reached the expected (match:above:below) ratio of 1:0:0 to qualify as reliable predictors of ureteric lengths. There is not sufficient evidence to conclude that anthropometric variables can reliably predict ureteric lengths. These variables appear to lack adequate specificity as they failed to reach the expected (match:above:below) ratio of 1:0:0. Consequently, selections of ureteral stents continue to remain a challenge. However, height (R (2)=0.68) with the (match:above:below) ratio of 3:3:4 appears suited for use as estimator, but on the basis of decision rule. Additional research is recommended for stent improvements and ureteric length determinations.

  3. Validation and Verification of Operational Land Analysis Activities at the Air Force Weather Agency

    Science.gov (United States)

    Shaw, Michael; Kumar, Sujay V.; Peters-Lidard, Christa D.; Cetola, Jeffrey

    2012-01-01

    The NASA developed Land Information System (LIS) is the Air Force Weather Agency's (AFWA) operational Land Data Assimilation System (LDAS) combining real time precipitation observations and analyses, global forecast model data, vegetation, terrain, and soil parameters with the community Noah land surface model, along with other hydrology module options, to generate profile analyses of global soil moisture, soil temperature, and other important land surface characteristics. (1) A range of satellite data products and surface observations used to generate the land analysis products (2) Global, 1/4 deg spatial resolution (3) Model analysis generated at 3 hours. AFWA recognizes the importance of operational benchmarking and uncertainty characterization for land surface modeling and is developing standard methods, software, and metrics to verify and/or validate LIS output products. To facilitate this and other needs for land analysis activities at AFWA, the Model Evaluation Toolkit (MET) -- a joint product of the National Center for Atmospheric Research Developmental Testbed Center (NCAR DTC), AFWA, and the user community -- and the Land surface Verification Toolkit (LVT), developed at the Goddard Space Flight Center (GSFC), have been adapted to operational benchmarking needs of AFWA's land characterization activities.

  4. Lack of correlation between telomere length and telomerase activity and expression in leukemic cells.

    Science.gov (United States)

    Januszkiewicz, Danuta; Wysoki, Jacek; Lewandowski, Krzysztof; Pernak, Monika; Nowicka, Karina; Rembowska, Jolanta; Nowak, Jerzy

    2003-12-01

    The expression of three components of telomerase complex (hTR, hTERT, TP1) along with telomerase activity and telomere length in leukemic cells was investigated. Cells were isolated from peripheral blood and/or bone marrow of children with acute lymphoblastic (ALL) and non-lymphoblastic (ANLL) leukemia. Expression of three components of telomerase as well as telomerase activity was found in all leukemic cells. Chemiluminescent detection of terminal restriction fragments (TRF) from DNA isolated from ALL cells showed variable patterns expressing considerable heterogeneity of telomere length. The ALL cells appeared to have both long and short telomere lengths, in contrast to normal peripheral lymphocytes, which produced limited pattern of TRF. The ANLL cells produced predominantly short telomere pattern despite high telomerase activity and expression. It can be concluded that high telomerase activity and expression in leukemic cells is not always correlated with long telomeres (TRF pattern).

  5. Verification of relationships between anthropometric variables among ureteral stents recipients and ureteric lengths: a challenge for Vitruvian-da Vinci theory

    Directory of Open Access Journals (Sweden)

    Acelam PA

    2015-08-01

    Full Text Available Philip A Acelam Walden University, College of Health Sciences, Minneapolis, MN, USA Objective: To determine and verify how anthropometric variables correlate to ureteric lengths and how well statistical models approximate the actual ureteric lengths. Materials and methods: In this work, 129 charts of endourological patients (71 females and 58 males were studied retrospectively. Data were gathered from various research centers from North and South America. Continuous data were studied using descriptive statistics. Anthropometric variables (age, body surface area, body weight, obesity, and stature were utilized as predictors of ureteric lengths. Linear regressions and correlations were used for studying relationships between the predictors and the outcome variables (ureteric lengths; P-value was set at 0.05. To assess how well statistical models were capable of predicting the actual ureteric lengths, percentages (or ratios of matched to mismatched results were employed. Results: The results of the study show that anthropometric variables do not correlate well to ureteric lengths. Statistical models can partially estimate ureteric lengths. Out of the five anthropometric variables studied, three of them: body frame, stature, and weight, each with a P<0.0001, were significant. Two of the variables: age (R2=0.01; P=0.20 and obesity (R2=0.03; P=0.06, were found to be poor estimators of ureteric lengths. None of the predictors reached the expected (match:above:below ratio of 1:0:0 to qualify as reliable predictors of ureteric lengths. Conclusion: There is not sufficient evidence to conclude that anthropometric variables can reliably predict ureteric lengths. These variables appear to lack adequate specificity as they failed to reach the expected (match:above:below ratio of 1:0:0. Consequently, selections of ureteral stents continue to remain a challenge. However, height (R2=0.68 with the (match:above:below ratio of 3:3:4 appears suited for use as

  6. Experimental verification of the effect of cable length on voltage distribution in stator winding of an induction motor under surge condition

    Energy Technology Data Exchange (ETDEWEB)

    Oyegoke, B.S. [Helsinki Univ. of Technology, Otaniemi (Finland). Lab. of Electromechanics

    1997-12-31

    This paper presents the results of surge distribution tests performed on a stator of a 6 kV induction motor. The primary aim of these tests was to determine the wave propagation properties of the machine winding fed via cables of different lengths. Considering the measured resorts, conclusions are derived regarding the effect of cable length on the surge distribution within the stator winding of an ac motor. (orig.) 15 refs.

  7. Influence of Amalaki Rasayana on telomerase activity and telomere length in human blood mononuclear cells.

    Science.gov (United States)

    Guruprasad, Kanive P; Dash, Sweta; Shivakumar, Marigowda B; Shetty, Pavithra R; Raghu, Kothanahalli S; Shamprasad, Bhanuvalli R; Udupi, Vishwanatha; Acharya, Raviraj V; Vidya, Prasanna B; Nayak, Jayakrishna; Mana, Anandan E; Moni, Rajesh; Sankaran, Muraleedharan T; Satyamoorthy, Kapaettu

    Indian traditional medicine practices use defined rasayana preparations to improve the quality of life in aged individuals. Amalaki Rasayana is one such rasayana prepared from the fruits of Phyllanthus emblica and is popularly used to prevent or treat various age related health conditions. Telomerase activity in the cells maintains telomere length and is implicated in ageing and various diseases wherein the shortening of telomere during ageing is controlled chiefly by the telomerase activity. In the present study, we investigated telomerase activity and telomere length in the peripheral blood mononuclear cells of aged individuals administered with Amalaki Rasayana. Amalaki Rasayana was administered to healthy, aged (45-60 years) volunteers for 45 days after koshta shuddhi procedure. The telomerase activity and telomere length were analyzed on 0, 45th and 90th days of Amalaki Rasayana administration in peripheral blood mononuclear cells from these individuals and compared with age-matched placebo group and young volunteers (22-30 years). The data were compared between the groups. The results indicated an increase in telomerase activity with no discernible change in telomere length in the Amalaki administered participants. The comparison between young and aged participants revealed higher telomerase activity in young participants with no significant differences in telomere length. The data indicate that the maintenance of telomere length is facilitated by an increase in telomerase activity upon rasayana administration in aged individuals and Amalaki Rasayana may prevent the erosion of telomeres over a period of time in aged individuals to promote healthy ageing. Copyright © 2017 Transdisciplinary University, Bangalore and World Ayurveda Foundation. Published by Elsevier B.V. All rights reserved.

  8. SU-E-J-141: Activity-Equivalent Path Length Approach for the 3D PET-Based Dose Reconstruction in Proton Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Attili, A; Vignati, A; Giordanengo, S [Istituto Nazionale di Fisica Nucleare, Sez. Torino, Torino (Italy); Kraan, A [Istituto Nazionale di Fisica Nucleare, Sez. Pisa, Pisa (Italy); Universita degli Studi di Pisa, Pisa (Italy); Dalmasso, F [Istituto Nazionale di Fisica Nucleare, Sez. Torino, Torino (Italy); Universita degli Studi di Torino, Torino (Italy); Battistoni, G [Istituto Nazionale di Fisica Nucleare, Sez. Milano, Milano (Italy)

    2015-06-15

    Purpose: Ion beam therapy is sensitive to uncertainties from treatment planning and dose delivery. PET imaging of induced positron emitter distributions is a practical approach for in vivo, in situ verification of ion beam treatments. Treatment verification is usually done by comparing measured activity distributions with reference distributions, evaluated in nominal conditions. Although such comparisons give valuable information on treatment quality, a proper clinical evaluation of the treatment ultimately relies on the knowledge of the actual delivered dose. Analytical deconvolution methods relating activity and dose have been studied in this context, but were not clinically applied. In this work we present a feasibility study of an alternative approach for dose reconstruction from activity data, which is based on relating variations in accumulated activity to tissue density variations. Methods: First, reference distributions of dose and activity were calculated from the treatment plan and CT data. Then, the actual measured activity data were cumulatively matched with the reference activity distributions to obtain a set of activity-equivalent path lengths (AEPLs) along the rays of the pencil beams. Finally, these AEPLs were used to deform the original dose distribution, yielding the actual delivered dose. The method was tested by simulating a proton therapy treatment plan delivering 2 Gy on a homogeneous water phantom (the reference), which was compared with the same plan delivered on a phantom containing inhomogeneities. Activity and dose distributions were were calculated by means of the FLUKA Monte Carlo toolkit. Results: The main features of the observed dose distribution in the inhomogeneous situation were reproduced using the AEPL approach. Variations in particle range were reproduced and the positions, where these deviations originated, were properly identified. Conclusions: For a simple inhomogeneous phantom the 3D dose reconstruction from PET-activity

  9. The Effect of Physical Activity agains the Telomere Length in the Leukocytes Cells of KONI Athletes

    Directory of Open Access Journals (Sweden)

    Endang Purwaningsih

    2017-07-01

    Full Text Available Telomeres are strands of non coding DNA at the ends of chromosomes that have the primary function to protect DNA from damage and maintain chromosomal stability. Physical exercise will increase the antioxidant activity can increase telomere proteins, lengthen telomeres and or protein networks associated with telomere so that the telomere remains long, or stopping telomere shortening. Telomere length was also associated with age. The purpose of the research was to determine telomere length of leukocyte cells in the KONI (Indonesian National Sports Committee athletes in Jakarta. The research method is descriptive, by measuring telomere length using quantitative PCR on leukocyte cells. Samples are KONI athletes from several sports, including men and women athletes, with ages between 15-20 years. Used a control group (not athletes is students of the Faculty of Medicine, University of YARSI. The results showed that there was no significant difference (p> 0.05 between telomere length group of athletes with the control group in both sexes. Similarly, telomere length between athlete male with female athletes also showed no significant difference (p> 0.05. It was concluded that physical exercise in athletes KONI at the age of 15- 20 years had no effect on telomere length in leukocytes. The results of this study provide information about the telomere length in Indonesian athletes at an early age.

  10. Length-force characteristics of the aponeurosis in the passive and active muscle condition and in the isolated condition

    NARCIS (Netherlands)

    Zuurbier, C. J.; Everard, A. J.; van der Wees, P.; Huijing, P. A.

    1994-01-01

    Length behaviour of the entire and designated parts of the proximal aponeurosis of the unipennate gastrocnemius medialis (GM) muscle of the rat was examined at muscle lengths ranging form muscle slack length to 4 mm above muscle optimum length in the passive and active (isometric contractions)

  11. Association of day length and weather conditions with physical activity levels in older community dwelling people.

    Directory of Open Access Journals (Sweden)

    Miles D Witham

    Full Text Available Weather is a potentially important determinant of physical activity. Little work has been done examining the relationship between weather and physical activity, and potential modifiers of any relationship in older people. We therefore examined the relationship between weather and physical activity in a cohort of older community-dwelling people.We analysed prospectively collected cross-sectional activity data from community-dwelling people aged 65 and over in the Physical Activity Cohort Scotland. We correlated seven day triaxial accelerometry data with daily weather data (temperature, day length, sunshine, snow, rain, and a series of potential effect modifiers were tested in mixed models: environmental variables (urban vs rural dwelling, percentage of green space, psychological variables (anxiety, depression, perceived behavioural control, social variables (number of close contacts and health status measured using the SF-36 questionnaire.547 participants, mean age 78.5 years, were included in this analysis. Higher minimum daily temperature and longer day length were associated with higher activity levels; these associations remained robust to adjustment for other significant associates of activity: age, perceived behavioural control, number of social contacts and physical function. Of the potential effect modifier variables, only urban vs rural dwelling and the SF-36 measure of social functioning enhanced the association between day length and activity; no variable modified the association between minimum temperature and activity.In older community dwelling people, minimum temperature and day length were associated with objectively measured activity. There was little evidence for moderation of these associations through potentially modifiable health, environmental, social or psychological variables.

  12. Interim Letter Report - Verification Survey Results for Activities Performed in March 2009 for the Vitrification Test Facility Warehouse at the West Valley Demonstration Project, Ashford, New York

    Energy Technology Data Exchange (ETDEWEB)

    B.D. Estes

    2009-04-24

    The objective of the verification activities was to provide independent radiological surveys and data for use by the Department of Energy (DOE) to ensure that the building satisfies the requirements for release without radiological controls.

  13. Influence of Amalaki Rasayana on telomerase activity and telomere length in human blood mononuclear cells

    Directory of Open Access Journals (Sweden)

    Kanive P. Guruprasad

    2017-04-01

    Conclusion: The data indicate that the maintenance of telomere length is facilitated by an increase in telomerase activity upon rasayana administration in aged individuals and Amalaki Rasayana may prevent the erosion of telomeres over a period of time in aged individuals to promote healthy ageing.

  14. AN APPROACH FOR ACTIVE SEGMENTATION OF UNCONSTRAINED HANDWRITTEN KOREAN STRINGS USING RUN-LENGTH CODE

    NARCIS (Netherlands)

    JeongSuk, J.; Kim, G.

    2004-01-01

    We propose an active handwritten Hangul segmentation method. A manageable structure based on Run-length code is defined in order to apply to preprocessing and segmentation. Also three fundamental candidate estimation functions are in- troduced to detect the clues on touching points, and the

  15. A Method Based on Active Appearance Model and Gradient Orientation Pyramid of Face Verification as People Age

    Directory of Open Access Journals (Sweden)

    Ji-Xiang Du

    2014-01-01

    Full Text Available Face verification in the presence of age progression is an important problem that has not been widely addressed. In this paper, we propose to use the active appearance model (AAM and gradient orientation pyramid (GOP feature representation for this problem. First, we use the AAM on the dataset and generate the AAM images; we then get the representation of gradient orientation on a hierarchical model, which is the appearance of GOP. When combined with a support vector machine (SVM, experimental results show that our approach has excellent performance on two public domain face aging datasets: FGNET and MORPH. Second, we compare the performance of the proposed methods with a number of related face verification methods; the results show that the new approach is more robust and performs better.

  16. Validation and Verification of the Operational Land Analysis Activities at the Air Force Weather Agency

    Science.gov (United States)

    Shaw, M.; Kumar, S.; Peters-Lidard, C. D.; Cetola, J.

    2011-12-01

    The importance of operational benchmarking and uncertainty characterization of land surface modeling can be clear upon considering the wide range of performance characteristics of numerical land surface models realizable through various combinations of factors. Such factors might include model physics and numerics, resolution, and forcing datasets used in operational implementation versus those that might have been involved in any prior development benchmarking. Of course, decisions concerning operational implementation may be better informed through more effective benchmarking of performance under various blends of such aforementioned operational factors. To facilitate this and other needs for land analysis activities at the Air Force Weather Agency (AFWA), the Model Evaluation Toolkit (MET) - a joint product of the National Center for Atmospheric Research Developmental Testbed Center (NCAR DTC), AFWA, and the user community - and the land information system (LIS) Verification Toolkit (LVT) - developed at the Goddard Space Flight Center (GSFC) - have been adapted to the operational benchmarking needs of AFWA's land characterization activities in order to compare the performance of new land modeling and related activities with that of previous activities as well as observational or analyzed datasets. In this talk, three examples of adaptations of MET and LVT to evaluation of LIS-related operations at AFWA will be presented. One example will include comparisons of new surface rainfall analysis capabilities, towards forcing of AFWA's LIS, with previous capabilities. Comparisons will be relative to retrieval-, model-, and measurement-based precipitation fields. Results generated via MET's grid-stat, neighborhood, wavelet, and object based evaluation (MODE) utilities adapted to AFWA's needs will be discussed. This example will be framed in the context of better informing optimal blends of land surface model (LSM) forcing data sources - namely precipitation data- under

  17. Verification of the Microgravity Active Vibration Isolation System based on Parabolic Flight

    Science.gov (United States)

    Zhang, Yong-kang; Dong, Wen-bo; Liu, Wei; Li, Zong-feng; Lv, Shi-meng; Sang, Xiao-ru; Yang, Yang

    2017-12-01

    The Microgravity active vibration isolation system (MAIS) is a device to reduce on-orbit vibration and to provide a lower gravity level for certain scientific experiments. MAIS system is made up of a stator and a floater, the stator is fixed on the spacecraft, and the floater is suspended by electromagnetic force so as to reduce the vibration from the stator. The system has 3 position sensors, 3 accelerometers, 8 Lorentz actuators, signal processing circuits and a central controller embedded in the operating software and control algorithms. For the experiments on parabolic flights, a laptop is added to MAIS for monitoring and operation, and a power module is for electric power converting. The principle of MAIS is as follows: the system samples the vibration acceleration of the floater from accelerometers, measures the displacement between stator and floater from position sensitive detectors, and computes Lorentz force current for each actuator so as to eliminate the vibration of the scientific payload, and meanwhile to avoid crashing between the stator and the floater. This is a motion control technic in 6 degrees of freedom (6-DOF) and its function could only be verified in a microgravity environment. Thanks for DLR and Novespace, we get a chance to take the DLR 27th parabolic flight campaign to make experiments to verify the 6-DOF control technic. The experiment results validate that the 6-DOF motion control technique is effective, and vibration isolation performance perfectly matches what we expected based on theoretical analysis and simulation. The MAIS has been planned on Chinese manned spacecraft for many microgravity scientific experiments, and the verification on parabolic flights is very important for its following mission. Additionally, we also test some additional function by microgravity electromagnetic suspension, such as automatic catching and locking and working in fault mode. The parabolic flight produces much useful data for these experiments.

  18. Verification of the Microgravity Active Vibration Isolation System based on Parabolic Flight

    Science.gov (United States)

    Zhang, Yong-kang; Dong, Wen-bo; Liu, Wei; Li, Zong-feng; Lv, Shi-meng; Sang, Xiao-ru; Yang, Yang

    2017-09-01

    The Microgravity active vibration isolation system (MAIS) is a device to reduce on-orbit vibration and to provide a lower gravity level for certain scientific experiments. MAIS system is made up of a stator and a floater, the stator is fixed on the spacecraft, and the floater is suspended by electromagnetic force so as to reduce the vibration from the stator. The system has 3 position sensors, 3 accelerometers, 8 Lorentz actuators, signal processing circuits and a central controller embedded in the operating software and control algorithms. For the experiments on parabolic flights, a laptop is added to MAIS for monitoring and operation, and a power module is for electric power converting. The principle of MAIS is as follows: the system samples the vibration acceleration of the floater from accelerometers, measures the displacement between stator and floater from position sensitive detectors, and computes Lorentz force current for each actuator so as to eliminate the vibration of the scientific payload, and meanwhile to avoid crashing between the stator and the floater. This is a motion control technic in 6 degrees of freedom (6-DOF) and its function could only be verified in a microgravity environment. Thanks for DLR and Novespace, we get a chance to take the DLR 27th parabolic flight campaign to make experiments to verify the 6-DOF control technic. The experiment results validate that the 6-DOF motion control technique is effective, and vibration isolation performance perfectly matches what we expected based on theoretical analysis and simulation. The MAIS has been planned on Chinese manned spacecraft for many microgravity scientific experiments, and the verification on parabolic flights is very important for its following mission. Additionally, we also test some additional function by microgravity electromagnetic suspension, such as automatic catching and locking and working in fault mode. The parabolic flight produces much useful data for these experiments.

  19. Pneumatic Muscles Actuated Lower-Limb Orthosis Model Verification with Actual Human Muscle Activation Patterns

    Directory of Open Access Journals (Sweden)

    Dzahir M.A.M

    2017-01-01

    Full Text Available A review study was conducted on existing lower-limb orthosis systems for rehabilitation which implemented pneumatic muscle type of actuators with the aim to clarify the current and on-going research in this field. The implementation of pneumatic artificial muscle will play an important role for the development of the advanced robotic system. In this research a derivation model for the antagonistic mono- and bi-articular muscles using pneumatic artificial muscles of a lower limb orthosis will be verified with actual human’s muscle activities models. A healthy and young male 29 years old subject with height 174cm and weight 68kg was used as a test subject. Two mono-articular muscles Vastus Medialis (VM and Vastus Lateralis (VL were selected to verify the mono-articular muscle models and muscle synergy between anterior muscles. Two biarticular muscles Rectus Femoris (RF and Bicep Femoris (BF were selected to verify the bi-articular muscle models and muscle co-contraction between anterior-posterior muscles. The test was carried out on a treadmill with a speed of 4.0 km/h, which approximately around 1.25 m/s for completing one cycle of walking motion. The data was collected for about one minute on a treadmill and 20 complete cycles of walking motion were successfully recorded. For the evaluations, the mathematical model obtained from the derivation and the actual human muscle activation patterns obtained using the surface electromyography (sEMG system were compared and analysed. The results shown that, high correlation values ranging from 0.83 up to 0.93 were obtained in between the derivation model and the actual human muscle’s model for both mono- and biarticular muscles. As a conclusion, based on the verification with the sEMG muscle activities data and its correlation values, the proposed derivation models of the antagonistic mono- and bi-articular muscles were suitable to simulate and controls the pneumatic muscles actuated lower limb

  20. 77 FR 28401 - Information Collection Activities: Legacy Data Verification Process (LDVP); Submitted for Office...

    Science.gov (United States)

    2012-05-14

    ... Verification Process (LDVP); Submitted for Office of Management and Budget (OMB) Review; Comment Request ACTION... comments on a collection of information that we will submit to the Office of Management and Budget (OMB... to January 2000 that do not have an assigned API number. This notice announces our intention to...

  1. Compositional verification of multi-agent systems: A formal analysis of pro-activeness and reactiveness

    NARCIS (Netherlands)

    Jonker, C.M.; Treur, J.

    1998-01-01

    A compositional method is presented for the verification of multi-agent systems. The advantages of the method are the well-structuredness of the proofs and the reusability of parts of these proofs in relation to reuse of components. The method is illustrated for an example multi-agent system,

  2. Compositional verification of multi-agent systems: A formal analysis of pro-activeness and reactiveness.

    NARCIS (Netherlands)

    Jonker, C.M.; Treur, J.

    2002-01-01

    A compositional method is presented for the verification of multi-agent systems. The advantages of the method are the well-structuredness of the proofs and the reusability of parts of these proofs in relation to reuse of components. The method is illustrated for an example multi-agent system,

  3. Active aging as a way of keeping diseases at arm’s length

    DEFF Research Database (Denmark)

    Lassen, Aske Juul

    Active ageing has increasingly become the ideal of how to live later life. Concepts of activity, participation and independence are central to how elderly see themselves and practice aging (Katz 2000). The elderly are encouraged and expected to stay active and independent. This is believed...... to be good for their quality of life, health, functionality and the economy (Sundhedsstyrelsen 2008, EC 2006, WHO 2002). At the same time active aging is inscribed into a general health care focus, which individualizes the responsibility for health and disease. This requires subjects ready to self......-care, by paying attention to the signals of the body and leading healthy lives (Rose 2001). However, active aging seems to contain an ambiguity in this aspect, as the practice of active aging is often a way for elderly to keep diseases at arm’s length, and not a way to sense the possible abnormalities in the body...

  4. Influence of Amalaki Rasayana on telomerase activity and telomere length in human blood mononuclear cells

    OpenAIRE

    Guruprasad, Kanive P.; Sweta Dash; Shivakumar, Marigowda B.; Pavithra R. Shetty; Kothanahalli S. Raghu; Shamprasad, Bhanuvalli R.; Vishwanatha Udupi; Acharya, Raviraj V.; Vidya, Prasanna B.; Jayakrishna Nayak; Anandan E. Mana; Rajesh Moni; Sankaran, Muraleedharan T.; Kapaettu Satyamoorthy

    2017-01-01

    Background: Indian traditional medicine practices use defined rasayana preparations to improve the quality of life in aged individuals. Amalaki Rasayana is one such rasayana prepared from the fruits of Phyllanthus emblica and is popularly used to prevent or treat various age related health conditions. Telomerase activity in the cells maintains telomere length and is implicated in ageing and various diseases wherein the shortening of telomere during ageing is controlled chiefly by the telomera...

  5. The correlated evolution of Runx2 tandem repeats, transcriptional activity, and facial length in carnivora.

    Science.gov (United States)

    Sears, K E; Goswami, A; Flynn, J J; Niswander, L A

    2007-01-01

    To assess the ability of protein-coding mutations to contribute to subtle, inter-specific morphologic evolution, here, we test the hypothesis that mutations within the protein-coding region of runt-related transcription factor 2 (Runx2) have played a role in facial evolution in 30 species from a naturally evolving group, the mammalian order Carnivora. Consistent with this hypothesis, we find significant correlations between changes in Runx2 glutamine-alanine tandem-repeat ratio, and both Runx2 transcriptional activity and carnivoran facial length. Furthermore, we identify a potential evolutionary mechanism for the correlation between Runx2 tandem repeat ratio and facial length. Specifically, our results are consistent with the Runx2 tandem repeat system providing a flexible genetic mechanism to rapidly change the timing of ossification. These heterochronic changes, in turn, potentially act on existing allometric variation in carnivoran facial length to generate the disparity in adult facial lengths observed among carnivoran species. Our results suggest that despite potentially great pleiotropic effects, changes to the protein-coding regions of genes such as Runx2 do occur and have the potential to affect subtle morphologic evolution across a diverse array of species in naturally evolving lineages.

  6. Groundwater flow code verification ``benchmarking`` activity (COVE-2A): Analysis of participants` work

    Energy Technology Data Exchange (ETDEWEB)

    Dykhuizen, R.C.; Barnard, R.W.

    1992-02-01

    The Nuclear Waste Repository Technology Department at Sandia National Laboratories (SNL) is investigating the suitability of Yucca Mountain as a potential site for underground burial of nuclear wastes. One element of the investigations is to assess the potential long-term effects of groundwater flow on the integrity of a potential repository. A number of computer codes are being used to model groundwater flow through geologic media in which the potential repository would be located. These codes compute numerical solutions for problems that are usually analytically intractable. Consequently, independent confirmation of the correctness of the solution is often not possible. Code verification is a process that permits the determination of the numerical accuracy of codes by comparing the results of several numerical solutions for the same problem. The international nuclear waste research community uses benchmarking for intercomparisons that partially satisfy the Nuclear Regulatory Commission (NRC) definition of code verification. This report presents the results from the COVE-2A (Code Verification) project, which is a subset of the COVE project.

  7. Depth profiling of residual activity of ^{237}U fragments as a range verification technique for ^{238}U primary ion beam

    Directory of Open Access Journals (Sweden)

    I. Strašík

    2012-07-01

    Full Text Available Experimental and simulation data concerning fragmentation of ^{238}U ion beam in aluminum, copper, and stainless-steel targets with the initial energy 500 and 950  MeV/u are collected in the paper. A range-verification technique based on depth profiling of residual activity is presented. The irradiated targets were constructed in the stacked-foil geometry and analyzed using gamma-ray spectroscopy. One of the purposes of these experiments was depth profiling of residual activity of induced nuclides and projectile fragments. Among the projectile fragments, special attention is paid to the ^{237}U isotope that has a range very close to the range of the primary ^{238}U ions. Therefore, the depth profiling of the ^{237}U isotope can be utilized for experimental verification of the ^{238}U primary-beam range, which is demonstrated and discussed in the paper. The experimental data are compared with computer simulations by FLUKA, SRIM, and ATIMA, as well as with complementary experiments.

  8. Depth profiling of residual activity of U237 fragments as a range verification technique for U238 primary ion beam

    Science.gov (United States)

    Strašík, I.; Chetvertkova, V.; Mustafin, E.; Pavlovič, M.; Belousov, A.

    2012-07-01

    Experimental and simulation data concerning fragmentation of U238 ion beam in aluminum, copper, and stainless-steel targets with the initial energy 500 and 950MeV/u are collected in the paper. A range-verification technique based on depth profiling of residual activity is presented. The irradiated targets were constructed in the stacked-foil geometry and analyzed using gamma-ray spectroscopy. One of the purposes of these experiments was depth profiling of residual activity of induced nuclides and projectile fragments. Among the projectile fragments, special attention is paid to the U237 isotope that has a range very close to the range of the primary U238 ions. Therefore, the depth profiling of the U237 isotope can be utilized for experimental verification of the U238 primary-beam range, which is demonstrated and discussed in the paper. The experimental data are compared with computer simulations by FLUKA, SRIM, and ATIMA, as well as with complementary experiments.

  9. Length of Residence and Vehicle Ownership in Relation to Physical Activity Among U.S. Immigrants.

    Science.gov (United States)

    Terasaki, Dale; Ornelas, India; Saelens, Brian

    2017-04-01

    Physical activity among U.S. immigrants over time is not well understood. Transportation may affect this trajectory. Using a survey of documented immigrants (N = 7240), we performed simple, then multivariable logistic regression to calculate ORs and 95 % CIs between length of residence (LOR) and both light-to-moderate (LPA) and vigorous (VPA) activity. We adjusted for demographic variables, then vehicle ownership to assess changes in ORs. Compared to new arrivals, all four LOR time-intervals were associated with lower odds of LPA and higher odds of VPA in simple analysis. All ORs for LPA remained significant after including demographics, but only one remained significant after adding vehicle ownership. Two ORs for VPA remained significant after including demographics and after adding vehicle ownership. Immigrants lower their light-to-moderate activity the longer they reside in the U.S., partly from substituting driving for walking. Efforts to maintain walking for transportation among immigrants are warranted.

  10. Active Stream Length Dynamics in Headwater Catchments Spanning Physiographic Provinces in the Appalachian Highlands

    Science.gov (United States)

    Jensen, C.; McGuire, K. J.

    2015-12-01

    One of the most basic descriptions of streams is the presence of channelized flow. However, this seemingly simple query goes unanswered for the majority of headwater networks, as stream length expands and contracts with the wetness of catchments seasonally, interannually, and in response to storm events. Although streams are known to grow and shrink, a lack of information on longitudinal dynamics across different geographic regions precludes effective management. Understanding the temporal variation in temporary network length over a broad range of settings is critical for policy decisions that impact aquatic ecosystem health. This project characterizes changes in active stream length for forested headwater catchments spanning four physiographic provinces of the Appalachian Highlands: the New England at Hubbard Brook Experimental Forest, New Hampshire; Valley and Ridge at Poverty Creek and the North Fork of Big Stony Creek in Jefferson National Forest, Virginia; Blue Ridge at Coweeta Hydrologic Laboratory, North Carolina; and Appalachian Plateau at Fernow Experimental Forest, West Virginia. Multivariate statistical analysis confirms these provinces exhibit characteristic topographies reflecting differences in climate, geology, and environmental history and, thus, merit separate consideration. The active streams of three watersheds (<45 ha) in each study area were mapped six times to capture a variety of moderate flow conditions that can be expected most of the time (i.e., exceedance probabilities between 25 to 75%). The geomorphic channel and channel heads were additionally mapped to determine how active stream length variability relates to the development of the geomorphic network. We found that drainage density can vary up to four-fold with discharge. Stream contraction primarily proceeds by increasing disconnection and disintegration into pools, while the number of flow origins remains constant except at high and low extremes of discharge. This work demonstrates

  11. Verification and accreditation schemes for climate change activities: A review of requirements for verification of greenhouse gas reductions and accreditation of verifiers—Implications for long-term carbon sequestration

    Science.gov (United States)

    Roed-Larsen, Trygve; Flach, Todd

    The purpose of this chapter is to provide a review of existing national and international requirements for verification of greenhouse gas reductions and associated accreditation of independent verifiers. The credibility of results claimed to reduce or remove anthropogenic emissions of greenhouse gases (GHG) is of utmost importance for the success of emerging schemes to reduce such emissions. Requirements include transparency, accuracy, consistency, and completeness of the GHG data. The many independent verification processes that have developed recently now make up a quite elaborate tool kit for best practices. The UN Framework Convention for Climate Change and the Kyoto Protocol specifications for project mechanisms initiated this work, but other national and international actors also work intensely with these issues. One initiative gaining wide application is that taken by the World Business Council for Sustainable Development with the World Resources Institute to develop a "GHG Protocol" to assist companies in arranging for auditable monitoring and reporting processes of their GHG activities. A set of new international standards developed by the International Organization for Standardization (ISO) provides specifications for the quantification, monitoring, and reporting of company entity and project-based activities. The ISO is also developing specifications for recognizing independent GHG verifiers. This chapter covers this background with intent of providing a common understanding of all efforts undertaken in different parts of the world to secure the reliability of GHG emission reduction and removal activities. These verification schemes may provide valuable input to current efforts of securing a comprehensive, trustworthy, and robust framework for verification activities of CO2 capture, transport, and storage.

  12. Physical activity and telomere length in U.S. men and women: An NHANES investigation.

    Science.gov (United States)

    Tucker, Larry A

    2017-07-01

    The principal objective was to determine the extent to which physical activity (PA) accounts for differences in leukocyte telomere length (LTL) in a large random sample of U.S. adults. Another purpose was to assess the extent to which multiple demographic and lifestyle covariates affect the relationship between PA and LTL. A total of 5823 adults from the National Health and Nutrition Examination Survey (NHANES 1999-2002) were studied cross-sectionally. Employing the quantitative polymerase chain reaction method, LTL was compared to standard reference DNA. PA was indexed using MET-minutes using self-reported frequency, intensity, and duration of participation in 62 physical activities. Covariates were controlled statistically. Telomeres were 15.6 base pairs shorter for each year of chronological age (F=723.2, Paccounting for years of reduced cellular aging compared to their more sedentary counterparts. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. 'Length'at Length

    Indian Academy of Sciences (India)

    Admin

    Translation invariance, axiom of choice, continuum hypothesis, axiom of determinateness. B V Rao was a Professor at the Indian Statistical. Institute, Kolkata. Currently he is with the. Chennai Mathematical. Institute. This is the story of length, one of the simplest concepts. Starting with the concept of length for intervals, we ...

  14. Leukocyte Telomere Length in Healthy Caucasian and African-American Adolescents : Relationships with Race, Sex, Adiposity, Adipokines, and Physical Activity

    NARCIS (Netherlands)

    Zhu, Haidong; Wang, Xiaoling; Gutin, Bernard; Davis, Catherine L.; Keeton, Daniel; Thomas, Jeffrey; Stallmann-Jorgensen, Inger; Mooken, Grace; Bundy, Vanessa; Snieder, Harold; van der Harst, Pim; Dong, Yanbin

    Objective To examine the relationships of race, sex, adiposity, adipokines, and physical activity to telomere length in adolescents. Study design Leukocyte telomere length (T/S ratio) was assessed cross-sectionally in 667 adolescents (aged 14-18 years; 48% African-Americans; 51% girls) using a

  15. Verification of Ceramic Structures

    Science.gov (United States)

    Behar-Lafenetre, Stephanie; Cornillon, Laurence; Rancurel, Michael; De Graaf, Dennis; Hartmann, Peter; Coe, Graham; Laine, Benoit

    2012-07-01

    In the framework of the “Mechanical Design and Verification Methodologies for Ceramic Structures” contract [1] awarded by ESA, Thales Alenia Space has investigated literature and practices in affiliated industries to propose a methodological guideline for verification of ceramic spacecraft and instrument structures. It has been written in order to be applicable to most types of ceramic or glass-ceramic materials - typically Cesic®, HBCesic®, Silicon Nitride, Silicon Carbide and ZERODUR®. The proposed guideline describes the activities to be performed at material level in order to cover all the specific aspects of ceramics (Weibull distribution, brittle behaviour, sub-critical crack growth). Elementary tests and their post-processing methods are described, and recommendations for optimization of the test plan are given in order to have a consistent database. The application of this method is shown on an example in a dedicated article [7]. Then the verification activities to be performed at system level are described. This includes classical verification activities based on relevant standard (ECSS Verification [4]), plus specific analytical, testing and inspection features. The analysis methodology takes into account the specific behaviour of ceramic materials, especially the statistical distribution of failures (Weibull) and the method to transfer it from elementary data to a full-scale structure. The demonstration of the efficiency of this method is described in a dedicated article [8]. The verification is completed by classical full-scale testing activities. Indications about proof testing, case of use and implementation are given and specific inspection and protection measures are described. These additional activities are necessary to ensure the required reliability. The aim of the guideline is to describe how to reach the same reliability level as for structures made of more classical materials (metals, composites).

  16. Impact of Backbone Tether Length and Structure on the Electrochemical Performance of Viologen Redox Active Polymers

    Energy Technology Data Exchange (ETDEWEB)

    Burgess, Mark; Chénard, Etienne; Hernández-Burgos, Kenneth; Nagarjuna, Gavvalapalli; Assary, Rajeev S.; Hui, Jingshu; Moore, Jeffrey S.; Rodríguez-López, Joaquín

    2016-10-25

    The design of chemically stable and electrochemically reversible redox active polymers (RAPs) is of great interest for energy storage technologies. Particularly, RAPs are new players for flow batteries relying on a size-exclusion based mechanism of electrolyte separation, but few studies have provided detailed molecular understanding of redox polymers in solution. Here, we use a systematic molecular design approach to investigate the impact of linker and redox-pendant electronic interactions on the performance of viologen RAPs. We used scanning electrochemical microscopy, cyclic voltammetry, bulk electrolysis, temperature-dependent absorbance, and spectroelectrochemistry to study the redox properties, charge transfer kinetics, and self-exchange of electrons through redox active dimers and their equivalent polymers. Stark contrast was observed between the electrochemical properties of viologen dimers and their corresponding polymers. Electron self-exchange kinetics in redox active dimers that only differ by their tether length and rigidity influences their charge transfer properties. Predictions from the Marcus Hush theory were consistent with observations in redox active dimers, but they failed to fully capture the behavior of macromolecular systems. For example, polymer bound viologen pendants, if too close in proximity, do not retain chemical reversibility. In contrast to polymer films, small modifications to the backbone structure decisively impact the bulk electrolysis of polymer solutions. This first comprehensive study highlights the careful balance between electronic interactions and backbone rigidity required to design RAPs with superior electrochemical performance.

  17. Translating Activity Diagram from Duration Calculus for Modeling of Real-Time Systems and its Formal Verification using UPPAAL and DiVinE

    Directory of Open Access Journals (Sweden)

    Muhammad Abdul Basit Ur Rehman

    2016-01-01

    Full Text Available The RTS (Real-Time Systems are widely used in industry, home appliances, life saving systems, aircrafts, and automatic weapons. These systems need more accuracy, safety, and reliability. An accurate graphical modeling and verification of such systems is really challenging. The formal methods made it possible to model such systems with more accuracy. In this paper, we envision a strategy to overcome the inadequacy of SysML (System Modeling Language for modeling and verification of RTS, and illustrate the framework by applying it on a case study of fuel filling machine. We have defined DC (Duration Calculus implementaion based formal semantics to specify the functionality of RTS. The activity diagram in then generated from these semantics. Finally, the graphical model is verified using UPPAAL and DiVinE model checkers for validation of timed and untimed properties with accelerated verification speed. Our results suggest the use of methodology for modeling and verification of large scale real-time systems with reduced verification cost.

  18. Structural insights into the architecture and allostery of full-length AMP-activated protein kinase.

    Science.gov (United States)

    Zhu, Li; Chen, Lei; Zhou, Xiao-Ming; Zhang, Yuan-Yuan; Zhang, Yi-Jiong; Zhao, Jing; Ji, Shang-Rong; Wu, Jia-Wei; Wu, Yi

    2011-04-13

    AMP-activated protein kinase (AMPK) is a heterotrimeric complex composed of α catalytic subunit, β scaffolding subunit, and γ regulatory subunit with critical roles in maintaining cellular energy homeostasis. However, the molecular architecture of the intact complex and the allostery associated with the adenosine binding-induced regulation of kinase activity remain unclear. Here, we determine the three-dimensional reconstruction and subunit organization of the full-length rat AMPK (α1β1γ1) through single-particle electron-microscopy. By comparing the structures of AMPK in ATP- and AMP-bound states, we are able to visualize the sequential conformational changes underlying kinase activation that transmits from the adenosine binding sites in the γ subunit to the kinase domain of the α subunit. These results not only make substantial revision to the current model of AMPK assembly, but also highlight a central role of the linker sequence of the α subunit in mediating the allostery of AMPK. Copyright © 2011 Elsevier Ltd. All rights reserved.

  19. Synthesis, preferred conformation, protease stability, and membrane activity of heptaibin, a medium-length peptaibiotic.

    Science.gov (United States)

    De Zotti, Marta; Biondi, Barbara; Peggion, Cristina; Park, Yoonkyung; Hahm, Kyung-Soo; Formaggio, Fernando; Toniolo, Claudio

    2011-08-01

    The medium-length peptaibiotics are characterized by a primary structure of 14-16 amino acid residues. Despite the interesting antibiotic and antifungal properties exhibited by these membrane-active peptides, their exact mechanism of action is still unknown. Here, we present our results on heptaibin, a 14-amino acid peptaibiotic found to exhibit antimicrobial activity against Staphylococcus aureus. We carried out the very challenging synthesis of heptaibin on solid phase and a detailed conformational analysis in solution. The peptaibiotic is folded in a mixed 3₁₀-/α-helix conformation which exhibits a remarkable amphiphilic character. We also find that it is highly stable toward degradation by proteolytic enzymes and nonhemolytic. Finally, fluorescence leakage experiments using small unilamellar vesicles of three different compositions revealed that heptaibin, although uncharged, is a selective compound for permeabilization of model membranes mimicking the overall negatively charged surface of Gram-positive bacteria. This latter finding is in agreement with the originally published antimicrobial activity data. Copyright © 2011 European Peptide Society and John Wiley & Sons, Ltd.

  20. Purification and activity testing of the full-length YycFGHI proteins of Staphylococcus aureus.

    Directory of Open Access Journals (Sweden)

    Michael Türck

    Full Text Available BACKGROUND: The YycFG two-component regulatory system (TCS of Staphylococcus aureus represents the only essential TCS that is almost ubiquitously distributed in gram-positive bacteria with a low G+C-content. YycG (WalK/VicK is a sensor histidine-kinase and YycF (WalR/VicR is the cognate response regulator. Both proteins play an important role in the biosynthesis of the cell envelope and mutations in these proteins have been involved in development of vancomycin and daptomycin resistance. METHODOLOGY/PRINCIPAL FINDINGS: Here we present high yield expression and purification of the full-length YycG and YycF proteins as well as of the auxiliary proteins YycH and YycI of Staphylococcus aureus. Activity tests of the YycG kinase and a mutated version, that harbours an Y306N exchange in its cytoplasmic PAS domain, in a detergent-micelle-model and a phosholipid-liposome-model showed kinase activity (autophosphorylation and phosphoryl group transfer to YycF only in the presence of elevated concentrations of alkali salts. A direct comparison of the activity of the kinases in the liposome-model indicated a higher activity of the mutated YycG kinase. Further experiments indicated that YycG responds to fluidity changes in its microenvironment. CONCLUSIONS/SIGNIFICANCE: The combination of high yield expression, purification and activity testing of membrane and membrane-associated proteins provides an excellent experimental basis for further protein-protein interaction studies and for identification of all signals received by the YycFGHI system.

  1. Nuclear disarmament verification

    Energy Technology Data Exchange (ETDEWEB)

    DeVolpi, A.

    1993-12-31

    Arms control treaties, unilateral actions, and cooperative activities -- reflecting the defusing of East-West tensions -- are causing nuclear weapons to be disarmed and dismantled worldwide. In order to provide for future reductions and to build confidence in the permanency of this disarmament, verification procedures and technologies would play an important role. This paper outlines arms-control objectives, treaty organization, and actions that could be undertaken. For the purposes of this Workshop on Verification, nuclear disarmament has been divided into five topical subareas: Converting nuclear-weapons production complexes, Eliminating and monitoring nuclear-weapons delivery systems, Disabling and destroying nuclear warheads, Demilitarizing or non-military utilization of special nuclear materials, and Inhibiting nuclear arms in non-nuclear-weapons states. This paper concludes with an overview of potential methods for verification.

  2. RNA Remodeling Activity of DEAD Box Proteins Tuned by Protein Concentration, RNA Length, and ATP.

    Science.gov (United States)

    Kim, Younghoon; Myong, Sua

    2016-09-01

    DEAD box RNA helicases play central roles in RNP biogenesis. We reported earlier that LAF-1, a DEAD box RNA helicase in C. elegans, dynamically interacts with RNA and that the interaction likely contributes to the fluidity of RNP droplets. Here we investigate the molecular basis of the interaction of RNA with LAF-1 and its human homolog, DDX3X. We show that both LAF-1 and DDX3X, at low concentrations, are monomers that induce tight compaction of single-stranded RNA. At high concentrations, the proteins are multimeric and dynamically interact with RNA in an RNA length-dependent manner. The dynamic LAF-1-RNA interaction stimulates RNA annealing activity. ATP adversely affects the RNA remodeling ability of LAF-1 by suppressing the affinity, dynamics, and annealing activity of LAF-1, suggesting that ATP may promote disassembly of the RNP complex. Based on our results, we postulate a plausible molecular mechanism underlying the dynamic equilibrium of the LAF-1 RNP complex. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Physical Activity, Physical Fitness and Leukocyte Telomere Length: the Cardiovascular Health Study.

    Science.gov (United States)

    Soares-Miranda, Luisa; Imamura, Fumiaki; Siscovick, David; Jenny, Nancy Swords; Fitzpatrick, Annette L; Mozaffarian, Dariush

    2015-01-01

    Introduction The influence of physical activity (PA) and physical fitness (PF) at older ages on changes in telomere length (TL), repetitive DNA sequences that may mark biologic aging, is not well-established. Few prior studies have been conducted in older adults, these were mainly cross-sectional, and few evaluated PF. Methods We investigated cross-sectional and prospective associations of PA and PF with leukocyte TL among 582 older adults (age 73±5 y at baseline) in the Cardiovascular Health Study, having serial TL measures and PA and PF assessed multiple times. Cross-sectional associations were assessed using multivariable repeated-measures regression, in which cumulatively averaged PA and PF measures were related to TL. Longitudinal analyses assessed cumulatively averaged PA and PF against later changes in TL; and changes in cumulatively averaged PA and PF against changes in TL. Results Cross-sectionally, greater walking distance and chair test performance, but not other PA and PF measures, were each associated with longer TL (p-trend=0.007, 0.04 respectively). In longitudinal analyses, no significant associations of baseline PA and PF with change in TL were observed. In contrast, changes in leisure-time activity and chair test performance were each inversely associated with changes in TL. Conclusions Cross-sectional analyses suggest that greater PA and PF are associated with longer TL. Prospective analyses show that changes in PA and PF are associated with differences in changes in TL. Even later in life, changes in certain PA and PF measures are associated with changes in TL, suggesting that leisure-time activity and fitness could reduce leukocyte telomere attrition among older adults. PMID:26083773

  4. A self-centering active probing technique for kinematic parameter identification and verification of articulated arm coordinate measuring machines

    Science.gov (United States)

    Santolaria, J.; Brau, A.; Velázquez, J.; Aguilar, J. J.

    2010-05-01

    A crucial task in the procedure of identifying the parameters of a kinematic model of an articulated arm coordinate measuring machine (AACMM) or robot arm is the process of capturing data. In this paper a capturing data method is analyzed using a self-centering active probe, which drastically reduces the capture time and the required number of positions of the gauge as compared to the usual standard and manufacturer methods. The mathematical models of the self-centering active probe and AACMM are explained, as well as the mathematical model that links the AACMM global reference system to the probe reference system. We present a self-calibration method that will allow us to determine a homogeneous transformation matrix that relates the probe's reference system to the AACMM last reference system from the probing of a single sphere. In addition, a comparison between a self-centering passive probe and self-centering active probe is carried out to show the advantages of the latter in the procedures of kinematic parameter identification and verification of the AACMM.

  5. Verification and validation benchmarks.

    Energy Technology Data Exchange (ETDEWEB)

    Oberkampf, William Louis; Trucano, Timothy Guy

    2007-02-01

    Verification and validation (V&V) are the primary means to assess the accuracy and reliability of computational simulations. V&V methods and procedures have fundamentally improved the credibility of simulations in several high-consequence fields, such as nuclear reactor safety, underground nuclear waste storage, and nuclear weapon safety. Although the terminology is not uniform across engineering disciplines, code verification deals with assessing the reliability of the software coding, and solution verification deals with assessing the numerical accuracy of the solution to a computational model. Validation addresses the physics modeling accuracy of a computational simulation by comparing the computational results with experimental data. Code verification benchmarks and validation benchmarks have been constructed for a number of years in every field of computational simulation. However, no comprehensive guidelines have been proposed for the construction and use of V&V benchmarks. For example, the field of nuclear reactor safety has not focused on code verification benchmarks, but it has placed great emphasis on developing validation benchmarks. Many of these validation benchmarks are closely related to the operations of actual reactors at near-safety-critical conditions, as opposed to being more fundamental-physics benchmarks. This paper presents recommendations for the effective design and use of code verification benchmarks based on manufactured solutions, classical analytical solutions, and highly accurate numerical solutions. In addition, this paper presents recommendations for the design and use of validation benchmarks, highlighting the careful design of building-block experiments, the estimation of experimental measurement uncertainty for both inputs and outputs to the code, validation metrics, and the role of model calibration in validation. It is argued that the understanding of predictive capability of a computational model is built on the level of

  6. Telomerase activity is increased and telomere length shortened in T cells from blood of patients with atopic dermatitis and psoriasis

    DEFF Research Database (Denmark)

    Wu, Kehuai; Higashi, N; Hansen, E R

    2000-01-01

    We studied telomerase activity and telomere length in PBMC and purified CD4(+) and CD8(+) T cells from blood obtained from a total of 32 patients with atopic dermatitis, 16 patients with psoriasis, and 30 normal controls. The telomerase activity was significantly increased in PBMC from the patients......(+) T cell subsets from normal donors. In conclusion, the increased telomerase activity and shortened telomere length indicates that T lymphocytes in atopic dermatitis and psoriasis are chronically stimulated and have an increased cellular turnover in vivo....

  7. 3D active shape models using gradient descent optimization of description length.

    Science.gov (United States)

    Heimann, Tobias; Wolf, Ivo; Williams, Tomos; Meinzer, Hans-Peter

    2005-01-01

    Active Shape Models are a popular method for segmenting three-dimensional medical images. To obtain the required landmark correspondences, various automatic approaches have been proposed. In this work, we present an improved version of minimizing the description length (MDL) of the model. To initialize the algorithm, we describe a method to distribute landmarks on the training shapes using a conformal parameterization function. Next, we introduce a novel procedure to modify landmark positions locally without disturbing established correspondences. We employ a gradient descent optimization to minimize the MDL cost function, speeding up automatic model building by several orders of magnitude when compared to the original MDL approach. The necessary gradient information is estimated from a singular value decomposition, a more accurate technique to calculate the PCA than the commonly used eigendecomposition of the covariance matrix. Finally, we present results for several synthetic and real-world datasets demonstrating that our procedure generates models of significantly better quality in a fraction of the time needed by previous approaches.

  8. School Nutrition Employees' Perceptions of Farm to School (FTS) Activities Differ Based on Management Type and FTS Participation Length

    Science.gov (United States)

    Kang, Sangwook; Arendt, Susan W.; Stokes, Nathan M.

    2016-01-01

    Purpose: The purpose of this study was to explore school nutrition employees' perceptions of FTS activities and whether the numbers of activities differ based on management type of school foodservice operation and length of FTS participation. Methods: The state with the most FTS programs from each of the eight national FTS regions was selected. A…

  9. Verification Games: Crowd-Sourced Formal Verification

    Science.gov (United States)

    2016-03-01

    VERIFICATION GAMES : CROWD-SOURCED FORMAL VERIFICATION UNIVERSITY OF WASHINGTON MARCH 2016 FINAL TECHNICAL REPORT...DATES COVERED (From - To) JUN 2012 – SEP 2015 4. TITLE AND SUBTITLE VERIFICATION GAMES : CROWD-SOURCED FORMAL VERIFICATION 5a. CONTRACT NUMBER FA8750...clarification memorandum dated 16 Jan 09. 13. SUPPLEMENTARY NOTES 14. ABSTRACT Over the more than three years of the project Verification Games : Crowd-sourced

  10. Telomerase activity is increased and telomere length shortened in T cells from blood of patients with atopic dermatitis and psoriasis

    DEFF Research Database (Denmark)

    Wu, Kehuai; Higashi, H; Hansen, E R

    2000-01-01

    We studied telomerase activity and telomere length in PBMC and purified CD4(+) and CD8(+) T cells from blood obtained from a total of 32 patients with atopic dermatitis, 16 patients with psoriasis, and 30 normal controls. The telomerase activity was significantly increased in PBMC from the patients...... compared with PBMC from normal donors. This increase was most pronounced in the subpopulation of CD4(+) T cells, which were significantly above the activity of the CD8(+) T cells in atopic dermatitis, psoriasis patients, and control persons. The telomere length was significantly reduced in all T cell...... subsets from both atopic dermatitis and psoriasis patients compared with normal individuals. Furthermore, the telomere length was found to be significantly shorter in CD4(+) memory T cells compared with the CD4(+) naive T cells, and both of the cell subsets from diseases were shown to be of significantly...

  11. Impact of accelerometer epoch length on physical activity and sedentary behaviour outcomes for preschool-aged children.

    Science.gov (United States)

    Colley, Rachel C; Harvey, Alysha; Grattan, Kimberly P; Adamo, Kristi B

    2014-01-01

    The Canadian Health Measures Survey uses accelerometry to collect physical activity and sedentary behaviour data. Between cycles 2 and 3, a transition was made from 60-second to 15-second epochs in accelerometry data for children aged 3 to 5. This study examines the impact of epoch length on physical activity and sedentary behaviour outcomes. Twenty-nine children aged 3 to 5 wore two accelerometers at the same time, one initialized to collect data in 60-second epochs, and the other, in 15-second epochs. Comparisons between epoch settings were made for several physical activity variables. Compared with the 60-second epoch setting, the 15-second setting captured more moderate-to-vigorous physical activity (MVPA) and sedentary time, but fewer steps and less light and total physical activity. The correlation between epoch settings was high for all variables except steps. The epoch length used in accelerometer data collection affects physical activity and sedentary behaviour data for preschool-aged children.

  12. Methods of Software Verification

    Directory of Open Access Journals (Sweden)

    R. E. Gurin

    2015-01-01

    Full Text Available This article is devoted to the problem of software verification (SW. Methods of software verification designed to check the software for compliance with the stated requirements such as correctness, system security and system adaptability to small changes in the environment, portability and compatibility, etc. These are various methods both by the operation process and by the way of achieving result. The article describes the static and dynamic methods of software verification and paid attention to the method of symbolic execution. In its review of static analysis are discussed and described the deductive method, and methods for testing the model. A relevant issue of the pros and cons of a particular method is emphasized. The article considers classification of test techniques for each method. In this paper we present and analyze the characteristics and mechanisms of the static analysis of dependencies, as well as their views, which can reduce the number of false positives in situations where the current state of the program combines two or more states obtained both in different paths of execution and in working with multiple object values. Dependences connect various types of software objects: single variables, the elements of composite variables (structure fields, array elements, the size of the heap areas, the length of lines, the number of initialized array elements in the verification code using static methods. The article pays attention to the identification of dependencies within the framework of the abstract interpretation, as well as gives an overview and analysis of the inference tools.Methods of dynamic analysis such as testing, monitoring and profiling are presented and analyzed. Also some kinds of tools are considered which can be applied to the software when using the methods of dynamic analysis. Based on the work a conclusion is drawn, which describes the most relevant problems of analysis techniques, methods of their solutions and

  13. Finite element analysis of vibration-driven electro-active paper energy harvester with experimental verification

    Directory of Open Access Journals (Sweden)

    Zafar Abas

    2015-02-01

    Full Text Available In this research work, a coupled-field finite element model of electro-active paper energy harvester is presented, and the results are verified experimentally. Electro-active paper is a smart form of cellulose coated with electrodes on both sides. A finite element model was developed, and harmonic and transient analyses were performed using a commercial finite element analysis package. Two 80 mm × 50 mm and 100 mm × 50 mm aluminum cantilever benders bonded with electro-active paper were tested to validate the finite element model results. Displacement and voltage generated by the energy harvester at the electrode surfaces were measured. The electro-active paper energy harvesters were excited at their fundamental resonance frequencies by a sinusoidal force located 18 mm from the free end. The voltage obtained from the 80 mm × 50 mm and 100 mm × 50 mm electro-active paper energy harvester finite element model was 3.7 and 7 mV, respectively. Experimental results have shown good agreement with the finite element model. The direct piezoelectric effect of electro-active paper shows potential for a cellulose-based eco-friendly energy harvester.

  14. Design, Development and Delivery of Active Learning Tools in Software Verification & Validation Education

    Science.gov (United States)

    Acharya, Sushil; Manohar, Priyadarshan Anant; Wu, Peter; Maxim, Bruce; Hansen, Mary

    2018-01-01

    Active learning tools are critical in imparting real world experiences to the students within a classroom environment. This is important because graduates are expected to develop software that meets rigorous quality standards in functional and application domains with little to no training. However, there is a well-recognized need for the…

  15. Verification of a characterization method of the laser-induced selective activation based on industrial lasers

    DEFF Research Database (Denmark)

    Zhang, Yang; Hansen, Hans Nørgaard; Tang, Peter T.

    2013-01-01

    In this article, laser-induced selective activation (LISA) for subsequent autocatalytic copper plating is performed by several types of industrial scale lasers, including a Nd:YAG laser, a UV laser, a fiber laser, a green laser, and a short pulsed laser. Based on analysis of all the laser-machine...

  16. Sarcomere length-dependence of activity-dependent twitch potentiation in mouse skeletal muscle

    Directory of Open Access Journals (Sweden)

    MacIntosh Brian R

    2002-12-01

    Full Text Available Abstract Background It has been reported that potentiation of a skeletal muscle twitch response is proportional to muscle length with a negative slope during staircase, and a positive slope during posttetanic potentiation. This study was done to directly compare staircase and posttetanic responses with measurement of sarcomere length to compare their length-dependence. Methods Mouse extensor digitorum longus (EDL muscles were dissected to small bundles of fibers, which permit measurement of sarcomere length (SL, by laser diffraction. In vitro fixed-end contractions of EDL fiber bundles were elicited at 22°C and 35°C at sarcomere lengths ranging from 2.35 μm to 3.85 μm. Twitch contractions were assessed before and after 1.5 s of 75 Hz stimulation at 22°C or during 10 s of 10 Hz stimulation at 22°C or 35°C. Results Staircase potentiation was greater at 35°C than 22°C, and the relative magnitude of the twitch contraction (Pt*/Pt was proportional to sarcomere length with a negative slope, over the range 2.3 μm – 3.7 μm. Linear regression yielded the following: Pt*/Pt = -0.59·SL+3.27 (r2 = 0.74; Pt*/Pt = -0.39·SL+2.34 (r2 = 0.48; and Pt*/Pt = -0.50·SL+2.45 (r2 = 0.80 for staircase at 35°C, and 22°C and posttetanic response respectively. Posttetanic depression rather than potentiation was present at long SL. This indicates that there may be two processes operating in these muscles to modulate the force: one that enhances and a second that depresses the force. Either or both of these processes may have a length-dependence of its mechanism. Conclusion There is no evidence that posttetanic potentiation is fundamentally different from staircase in these muscles.

  17. Final Report - Independent Verification Survey Activities at the Seperations Process Research Unit Sites, Niskayuna, New York

    Energy Technology Data Exchange (ETDEWEB)

    Evan Harpenau

    2011-03-15

    The Separations Process Research Unit (SPRU) complex located on the Knolls Atomic Power Laboratory (KAPL) site in Niskayuna, New York, was constructed in the late 1940s to research the chemical separation of plutonium and uranium (Figure A-1). SPRU operated as a laboratory scale research facility between February 1950 and October 1953. The research activities ceased following the successful development of the reduction oxidation and plutonium/uranium extraction processes. The oxidation and extraction processes were subsequently developed for large scale use by the Hanford and Savannah River sites (aRc 2008a). Decommissioning of the SPRU facilities began in October 1953 and continued through the 1990s.

  18. Prompt {gamma}-ray activation analysis of Martian analogues at the FRM II neutron reactor and the verification of a Monte Carlo planetary radiation environment model

    Energy Technology Data Exchange (ETDEWEB)

    Skidmore, M.S. [Space Research Centre, Department of Physics and Astronomy, University of Leicester, University Road, Leicester LE1 7RH (United Kingdom)], E-mail: mss16@star.le.ac.uk; Ambrosi, R.M.; Vernon, D. [Space Research Centre, Department of Physics and Astronomy, University of Leicester, University Road, Leicester LE1 7RH (United Kingdom); Calzada, E. [Neutronentomographie ANTARES, Forschungsreaktor FRM II, Technische Universitaet Muenchen, D-85747 Garching (Germany); Benedix, G.K. [Department of Mineralogy, Natural History Museum, Cromwell Road, London SW7 5BD (United Kingdom); Buecherl, T. [Lehrstuhl fuer Radiochemie, TU Muenchen, Walther-Meissner-Str. 3, Garching 85748 (Germany); Schillinger, B. [Neutronentomographie ANTARES, Forschungsreaktor FRM II, Technische Universitaet Muenchen, D-85747 Garching (Germany)

    2009-08-11

    Planetary radiation environment modelling is important to assess the habitability of a planetary body. It is also useful when interpreting the {gamma}-ray data produced by natural emissions from radioisotopes or prompt {gamma}-ray activation analysis. {gamma}-ray spectra acquired in orbit or in-situ by a suitable detector can be converted into meaningful estimates of the concentration of certain elements on the surface of a planet. This paper describes the verification of a Monte Carlo model developed using the MCNPX code at University of Leicester. The model predicts the performance of a geophysical package containing a {gamma}-ray spectrometer operating at a depth of up to 5 m. The experimental verification of the Monte Carlo model was performed at the FRM II facility in Munich, Germany. The paper demonstrates that the model is in good agreement with the experimental data and can be used to model the performance of an in-situ {gamma}-ray spectrometer.

  19. Medial gastrocnemius muscle fascicle active torque-length and Achilles tendon properties in young adults with spastic cerebral palsy.

    Science.gov (United States)

    Barber, Lee; Barrett, Rod; Lichtwark, Glen

    2012-10-11

    Individuals with spastic cerebral palsy (CP) typically experience muscle weakness. The mechanisms responsible for muscle weakness in spastic CP are complex and may be influenced by the intrinsic mechanical properties of the muscle and tendon. The purpose of this study was to investigate the medial gastrocnemius (MG) muscle fascicle active torque-length and Achilles tendon properties in young adults with spastic CP. Nine relatively high functioning young adults with spastic CP (GMFCS I, 17±2 years) and 10 typically developing individuals (18±2 years) participated in the study. Active MG torque-length and Achilles tendon properties were assessed under controlled conditions on a dynamometer. EMG was recorded from leg muscles and ultrasound was used to measure MG fascicle length and Achilles tendon length during maximal isometric contractions at five ankle angles throughout the available range of motion and during passive rotations imposed by the dynamometer. Compared to the typically developing group, the spastic CP group had 33% lower active ankle plantarflexion torque across the available range of ankle joint motion, partially explained by 37% smaller MG muscle and 4% greater antagonistic co-contraction. The Achilles tendon slack length was also 10% longer in the spastic CP group. This study confirms young adults with mild spastic CP have altered muscle-tendon mechanical properties. The adaptation of a longer Achilles tendon may facilitate a greater storage and recovery of elastic energy and partially compensate for decreased force and work production by the small muscles of the triceps surae during activities such as locomotion. Copyright © 2012 Elsevier Ltd. All rights reserved.

  20. Availability verification of information for human system interface in automatic SG level control using activity diagram

    Energy Technology Data Exchange (ETDEWEB)

    Nuraslinda, Anuar; Kim, Dong Young; Kim, Jong Hyun [KEPCO International Nuclear Graduate School, Uljugun (Korea, Republic of)

    2012-10-15

    Steam Generator (SG) level control system in OPR 1000 is one of representative automatic systems that falls under the Supervisory Control level in Endsley's taxonomy. Supervisory control of automated systems is classified as a form of out of the loop (OOTL) performance due to passive involvement in the systems operation, which could lead to loss of situation awareness (SA). There was a reported event, which was caused by inadequate human automation communication that contributed to an unexpected reactor trip in July 2005. A high SG level trip occurred in Yeonggwang (YGN) Unit 6 Nuclear Power Plant (NPP) due to human operator failure to recognize the need to change the control mode of the economizer valve controller (EVC) to manual mode during swap over (the transition from low power mode to high power mode) after the loss of offsite power (LOOP) event was recovered. This paper models the human system interaction in NPP SG level control system using Unified Modeling Language (UML) Activity Diagram. Then, it identifies the missing information for operators in the OPR1000 Main Control Room (MCR) and suggests some means of improving the human system interaction.

  1. The primary culture of carp (Cyprinus carpio) macrophages and the verification of its phagocytosis activity.

    Science.gov (United States)

    Qiu, Wenhui; Liu, Shuai; Chen, Jingsi; Hu, Lei; Wu, Minghong; Yang, Ming

    2016-01-01

    This study establishes the primary culture method for red carp (Cyprinus carpio) macrophages in vitro and lays the foundation for further research in the fish immune system. The healthy adult red carp was chosen, and mechanical separation and cell adherent culture methods were used to isolate the primary macrophages. Compared to the traditional method of Percoll discontinuous density gradient isolation, the protocol we reported here makes cell isolation steps more concise and obtains more healthy cells with high macrophage purity. The cells were uniform in size with a clearly visible nucleus. Trypan blue staining and non-radioactive cell proliferation assay were used to detect the cell survival rate. Further, we provide optimum culture conditions which include cell density (1 × 10(7) cells/mL), culture medium (Leibovitz's L-15), pH (7.2-7.4), temperature (26°C), and adherent time (24 h). Macrophages have been identified by nonspecific esterase and Wright-Giemsa staining and have shown to grow very well. In addition, the macrophages have a very strong bactericidal activity against three kinds of bacteria, further verifying good growth conditions and proper function.

  2. Synthesis and antimicrobial activity of dimethyl- and trimethyl-substituted phosphonium salts with alkyl chains of various lengths.

    Science.gov (United States)

    Kanazawa, A; Ikeda, T; Endo, T

    1994-01-01

    Various phosphonium salts possessing single or double alkyl chains of various lengths (C10 to C18) were prepared as cationic biocides, and their antimicrobial activities against 11 typical strains of microorganisms including methicillin-resistant Staphylococcus aureus (MRSA) were evaluated. The phosphonium salts with long alkyl chains were found to show high levels of antimicrobial activity. Their activities depended strongly on the molecular structure, and a correlation between antimicrobial activity and molecular structure was observed. In the alkyltrimethylphosphonium salts, the bactericidal activity against S. aureus and Escherichia coli increased with increasing alkyl chain length, and the compound with the longest alkyl chain (C18) killed all the bacterial cells (ca. 10(7) cells per ml) within 30 min of contact at concentrations of 2.8 and 28 microM, respectively. In contrast, the bactericidal activity of dialkyldimethylphosphonium salts was found to decrease as the chain length of the substituents increased. It is significant that the phosphonium biocide containing double decyl groups exhibited the broadest spectrum of activity against microorganisms tested and showed the greatest bacteriostatic activity against MRSA (MIC = 0.78 micrograms/ml). Furthermore, we systematically investigated differences in bactericidal activity between the phosphonium salts and commonly available ammonium salts with the same hydrophobic structure. It was observed that the phosphonium salts showed an advantage over the corresponding ammonium salts in bactericidal activity and killing rate. For example, tetradecyltrimethyl- and didecyldimethylphosphonium chlorides killed all S. aureus organisms (ca. 10(7) cells per ml) within 60 and 30 min of exposure at 28 and 2.8 microM, respectively, while tetradecyltrimethyl- and didecyldimethylammonium chlorides which are representative of the existing cationic disinfectants did not kill all the bacteria even at the longest exposure time (120

  3. Effect of grass silage chop length on chewing activity and digestibility

    DEFF Research Database (Denmark)

    Garmo, T.H.; Randby, Å.T.; Eknæs, M.

    2008-01-01

    ad libitum and supplemented with 6 kg concentrate. Early harvested silage significantly decreased total ration eating (ET), rumination (RT) and chewing time (CT) per kg silage DM compared with normal harvested silage (CT = 38 vs. 46 min kg-1 DM). Chopping of silage reduced CT significantly, mainly...... due to reduced ET, CT = 45, 41 and 39 min kg-1 DM for rations with long, coarsely and finely chopped silage, respectively. Grass silage chop length did not influence diet digestibility, but there was a significant effect of harvesting time on digestibility. No interaction between harvesting time...

  4. Field Test and Performance Verification: Integrated Active Desiccant Rooftop Hybrid System Installed in a School - Final Report: Phase 4A

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, J

    2005-12-21

    This report summarizes the results of a field verification pilot site investigation that involved the installation of a hybrid integrated active desiccant/vapor-compression rooftop heating, ventilation, and air-conditioning (HVAC) unit at an elementary school in the Atlanta Georgia area. For years, the school had experienced serious humidity and indoor air quality (IAQ) problems that had resulted in occupant complaints and microbial (mold) remediation. The outdoor air louvers of the original HVAC units had been closed in an attempt to improve humidity control within the space. The existing vapor compression variable air volume system was replaced by the integrated active desiccant rooftop (IADR) system that was described in detail in an Oak Ridge National Laboratory (ORNL) report published in 2004 (Fischer and Sand 2004). The IADR system and all space conditions have been monitored remotely for more than a year. The hybrid system was able to maintain both the space temperature and humidity as desired while delivering the outdoor air ventilation rate required by American Society of Heating, Refrigerating and Air-Conditioning Engineers Standard 62. The performance level of the IADR unit and the overall system energy efficiency was measured and found to be very high. A comprehensive IAQ investigation was completed by the Georgia Tech Research Institute before and after the system retrofit. Before-and-after data resulting from this investigation confirmed a significant improvement in IAQ, humidity control, and occupant comfort. These observations were reported by building occupants and are echoed in a letter to ORNL from the school district energy manager. The IADR system was easily retrofitted in place of the original rooftop system using a custom curb adapter. All work was completed in-house by the school's maintenance staff over one weekend. A subsequent cost analysis completed for the school district by the design engineer of record concluded that the IADR

  5. Complete Functional Verification

    OpenAIRE

    Bormann, Joerg (Dr.)

    2017-01-01

    The dissertation describes a practically proven, particularly efficient approach for the verification of digital circuit designs. The approach outperforms simulation based verification wrt. final circuit quality as well as wrt. required verification effort. In the dissertation, the paradigm of transaction based verification is ported from simulation to formal verification. One consequence is a particular format of formal properties, called operation properties. Circuit descriptions are verifi...

  6. Immobilization of lipases on alkyl silane modified magnetic nanoparticles: effect of alkyl chain length on enzyme activity.

    Science.gov (United States)

    Wang, Jiqian; Meng, Gang; Tao, Kai; Feng, Min; Zhao, Xiubo; Li, Zhen; Xu, Hai; Xia, Daohong; Lu, Jian R

    2012-01-01

    Biocatalytic processes often require a full recycling of biocatalysts to optimize economic benefits and minimize waste disposal. Immobilization of biocatalysts onto particulate carriers has been widely explored as an option to meet these requirements. However, surface properties often affect the amount of biocatalysts immobilized, their bioactivity and stability, hampering their wide applications. The aim of this work is to explore how immobilization of lipases onto magnetite nanoparticles affects their biocatalytic performance under carefully controlled surface modification. Magnetite nanoparticles, prepared through a co-precipitation method, were coated with alkyl silanes of different alkyl chain lengths to modulate their surface hydrophobicity. Candida rugosa lipase was then directly immobilized onto the modified nanoparticles through hydrophobic interaction. Enzyme activity was assessed by catalytic hydrolysis of p-nitrophenyl acetate. The activity of immobilized lipases was found to increase with increasing chain length of the alkyl silane. Furthermore, the catalytic activities of lipases immobilized on trimethoxyl octadecyl silane (C18) modified Fe(3)O(4) were a factor of 2 or more than the values reported from other surface immobilized systems. After 7 recycles, the activities of the lipases immobilized on C18 modified nanoparticles retained 65%, indicating significant enhancement of stability as well through hydrophobic interaction. Lipase immobilized magnetic nanoparticles facilitated easy separation and recycling with high activity retaining. The activity of immobilized lipases increased with increasing alkyl chain length of the alkyl trimethoxy silanes used in the surface modification of magnetite nanoparticles. Lipase stability was also improved through hydrophobic interaction. Alkyl silane modified magnetite nanoparticles are thus highly attractive carriers for enzyme immobilization enabling efficient enzyme recovery and recycling.

  7. Immobilization of lipases on alkyl silane modified magnetic nanoparticles: effect of alkyl chain length on enzyme activity.

    Directory of Open Access Journals (Sweden)

    Jiqian Wang

    Full Text Available BACKGROUND: Biocatalytic processes often require a full recycling of biocatalysts to optimize economic benefits and minimize waste disposal. Immobilization of biocatalysts onto particulate carriers has been widely explored as an option to meet these requirements. However, surface properties often affect the amount of biocatalysts immobilized, their bioactivity and stability, hampering their wide applications. The aim of this work is to explore how immobilization of lipases onto magnetite nanoparticles affects their biocatalytic performance under carefully controlled surface modification. METHODOLOGY/PRINCIPAL FINDINGS: Magnetite nanoparticles, prepared through a co-precipitation method, were coated with alkyl silanes of different alkyl chain lengths to modulate their surface hydrophobicity. Candida rugosa lipase was then directly immobilized onto the modified nanoparticles through hydrophobic interaction. Enzyme activity was assessed by catalytic hydrolysis of p-nitrophenyl acetate. The activity of immobilized lipases was found to increase with increasing chain length of the alkyl silane. Furthermore, the catalytic activities of lipases immobilized on trimethoxyl octadecyl silane (C18 modified Fe(3O(4 were a factor of 2 or more than the values reported from other surface immobilized systems. After 7 recycles, the activities of the lipases immobilized on C18 modified nanoparticles retained 65%, indicating significant enhancement of stability as well through hydrophobic interaction. Lipase immobilized magnetic nanoparticles facilitated easy separation and recycling with high activity retaining. CONCLUSIONS/SIGNIFICANCE: The activity of immobilized lipases increased with increasing alkyl chain length of the alkyl trimethoxy silanes used in the surface modification of magnetite nanoparticles. Lipase stability was also improved through hydrophobic interaction. Alkyl silane modified magnetite nanoparticles are thus highly attractive carriers for

  8. The role of alkyl chain length in the inhibitory effect n-alkyl xanthates on mushroom tyrosinase activities.

    Science.gov (United States)

    Saboury, Ali Akbar; Alijanianzadeh, Mahdi; Mansoori-Torshizi, Hasan

    2007-01-01

    Sodium salts of four n-alkyl xanthate compounds, C2H5OCS2Na (I), C3H7OCS2Na (II), C4H9OCS2Na (III), and C6H13OCS2Na (IV) were synthesized and examined for inhibition of both cresolase and catecholase activities of mushroom tyrosinase (MT) in 10 mM sodium phosphate buffer, pH 6.8, at 293 K using UV spectrophotometry. 4-[(4-Methylbenzo)azo]-1,2-benzendiol (MeBACat) and 4-[(4-methylphenyl)azo]-phenol (MePAPh) were used as synthetic substrates for the enzyme for catecholase and cresolase reactions, respectively. Lineweaver-Burk plots showed different patterns of mixed, competitive or uncompetitive inhibition for the four xanthates. For the cresolase activity, I and II showed uncompetitive inhibition but III and IV showed competitive inhibition pattern. For the catecholase activity, I and II showed mixed inhibition but III and IV showed competitive inhibition. The synthesized compounds can be classified as potent inhibitors of MT due to their Ki values of 13.8, 11, 8 and 5 microM for the cresolase activity, and 1.4, 5, 13 and 25 microM for the catecholase activity for I, II, III and IV, respectively. For the catecholase activity both substrate and inhibitor can be bound to the enzyme with negative cooperativity between the binding sites (alpha > 1) and this negative cooperativity increases with increasing length of the aliphatic tail of these compounds. The length of the hydrophobic tail of the xanthates has a stronger effect on the Ki values for catecholase inhibition than for cresolase inhibition. Increasing the length of the hydrophobic tail leads to a decrease of the Ki values for cresolase inhibition and an increase of the Ki values for catecholase inhibition.

  9. Estimation of Active Stream Network Length in a Hilly Headwater Catchment Using Recession Flow Analysis

    National Research Council Canada - National Science Library

    Wei Li; Ke Zhang; Yuqiao Long; Li Feng

    2017-01-01

    .... Regarding the correlation between active stream networks and stream recession flow characteristics, we developed a new method to estimate the ASNL, under different wetness conditions, of a catchment...

  10. Saccharomyces cerevisiae Hrq1 helicase activity is affected by the sequence but not the length of single-stranded DNA.

    Science.gov (United States)

    Rogers, Cody M; Bochman, Matthew L

    2017-05-13

    Mutations in the human RecQ4 DNA helicase are associated with three different diseases characterized by genomic instability. To gain insight into how RecQ4 dysfunction leads to these pathologies, several groups have used the Saccharomyces cerevisiae RecQ4 homolog Hrq1 as an experimental model. Hrq1 displays many of the same functions as RecQ4 in vivo and in vitro. However, there is some disagreement in the literature about the effects of single-stranded DNA (ssDNA) length on Hrq1 helicase activity and the ability of Hrq1 to anneal complementary ssDNA oligonucleotides into duplex DNA. Here, we present a side-by-side comparison of Hrq1 and RecQ4 helicase activity, demonstrating that in both cases, long random-sequence 3' ssDNA tails inhibit DNA unwinding in vitro in a length-dependent manner. This appears to be due to the formation of secondary structures in the random-sequence ssDNA because Hrq1 preferentially unwound poly(dT)-tailed forks independent of ssDNA length. Further, RecQ4 is capable of ssDNA strand annealing and annealing-dependent strand exchange, but Hrq1 lacks these activities. These results establish the importance of DNA sequence in Hrq1 helicase activity, and the absence of Hrq1 strand annealing activity explains the previously identified discrepancies between S. cerevisiae Hrq1 and human RecQ4. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. The length of a lantibiotic hinge region has profound influence on antimicrobial activity and host specificity

    Directory of Open Access Journals (Sweden)

    Liang eZhou

    2015-01-01

    Full Text Available Lantibiotics are ribosomally synthesized (methyllanthionine containing peptides which can efficiently inhibit the growth of Gram-positive bacteria. As lantibiotics kill bacteria efficiently and resistance to them is difficult to be obtained, they have the potential to be used in many applications, e.g. in pharmaceutical industry or food industry. Nisin can inhibit the growth of Gram-positive bacteria by binding to lipid II and by making pores in their membrane. The C-terminal part of nisin is known to play an important role during translocation over the membrane and forming pore complexes. However, as the thickness of bacterial membranes varies between different species and environmental conditions, this property could have an influence on the pore forming activity of nisin. To investigate this, the so-called hinge region of nisin (residues NMK was engineered to vary from one to six amino acid residues and specific activity against different indicators was compared. Antimicrobial activity in liquid culture assays showed that wild type nisin is most active, while truncation of the hinge region dramatically reduced the activity of the peptide. However, one or two amino acids extensions showed only slightly reduced activity against most indicator strains. Notably, some variants (+2, +1, -1, -2 exhibited higher antimicrobial activity than nisin in agar well diffusion assays against Lactococcus lactis MG1363, Listeria monocytogenes, Enterococcus faecalis VE14089, Bacillus sporothermodurans IC4 and Bacillus cereus 4153 at certain temperatures.

  12. The Influence of Alcohol Consumption, Cigarette Smoking, and Physical Activity on Leukocyte Telomere Length

    National Research Council Canada - National Science Library

    Latifovic, Lidija; Peacock, Sarah D; Massey, Thomas E; King, Will D

    2016-01-01

    ...): alcohol consumption, smoking, and physical activity. This cross-sectional study included 477 healthy volunteers ages 20 to 50 years who completed a questionnaire and provided a fasting blood sample...

  13. Influence of posture and muscle length on stretch reflex activity in poststroke patients with spasticity

    NARCIS (Netherlands)

    Fleuren, J.F.M.; Fleuren, Judith F.; Nederhand, Marcus Johannes; Hermens, Hermanus J.

    Objective To investigate the influence of different positions on stretch reflex activity of knee flexors and extensors measured by electromyography in poststroke patients with spasticity and its expression in the Ashworth Scale.

  14. Model-based design and experimental verification of a monitoring concept for an active-active electromechanical aileron actuation system

    Science.gov (United States)

    Arriola, David; Thielecke, Frank

    2017-09-01

    Electromechanical actuators have become a key technology for the onset of power-by-wire flight control systems in the next generation of commercial aircraft. The design of robust control and monitoring functions for these devices capable to mitigate the effects of safety-critical faults is essential in order to achieve the required level of fault tolerance. A primary flight control system comprising two electromechanical actuators nominally operating in active-active mode is considered. A set of five signal-based monitoring functions are designed using a detailed model of the system under consideration which includes non-linear parasitic effects, measurement and data acquisition effects, and actuator faults. Robust detection thresholds are determined based on the analysis of parametric and input uncertainties. The designed monitoring functions are verified experimentally and by simulation through the injection of faults in the validated model and in a test-rig suited to the actuation system under consideration, respectively. They guarantee a robust and efficient fault detection and isolation with a low risk of false alarms, additionally enabling the correct reconfiguration of the system for an enhanced operational availability. In 98% of the performed experiments and simulations, the correct faults were detected and confirmed within the time objectives set.

  15. Synthesis and Antimicrobial Activity of Carboxylate Phosphabetaines Derivatives with Alkyl Chains of Various Lengths

    Directory of Open Access Journals (Sweden)

    Irina V. Galkina

    2013-01-01

    Full Text Available The purpose of the present study was to investigate the antibacterial activity of fifteen novel nanosized alkyl esters of carboxylate phosphabetaine: β-(carboxyalkylethyltriphenylphosphonium bromides 4–8, β-(carboxyalkyl-β-methylethyltriphenylphosphonium bromides 9–13, and β-(carboxyalkyl-α-methylethyltriphenylphosphonium bromides 14–18. The in vitro microbiological activity of the synthesized phosphonium bromides against gram-positive and gram-negative bacteria and the yeast Candida albicans was determined in comparison to standard agents. Microbiological results indicate that the synthesized phosphonium salts 4–18 possess a broad spectrum of activity against the tested microorganisms. Every newly synthesized compound was characterized by elemental analyses, IR, 1H NMR, and 31P NMR spectral studies.

  16. Influence of Day Length and Physical Activity on Sleep Patterns in Older Icelandic Men and Women

    DEFF Research Database (Denmark)

    Brychta, Robert J; Arnardóttir, Nanna Ýr; Jóhannsson, Erlingur

    2016-01-01

    Study Objectives: To identify cross-sectional and seasonal patterns of sleep and physical activity (PA) in community-dwelling, older Icelandic adults using accelerometers. Methods: A seven-day free-living protocol of 244 (110 female) adults aged 79.7 +/- 4.9 years was conducted as part of a larger...

  17. Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines.

    Science.gov (United States)

    Strahl, C; Blackburn, E H

    1996-01-01

    The ribonucleoprotein telomerase, a specialized cellular reverse transcriptase, synthesizes one strand of the telomeric DNA of eukaryotes. We analyzed telomere maintenance in two immortalized human cell lines: the B-cell line JY616 and the T-cell line Jurkat E6-1, and determined whether known inhibitors of retroviral reverse transcriptases could perturb telomere lengths and growth rates of these cells in culture. Dideoxyguanosine (ddG) caused reproducible, progressive telomere shortening over several weeks of passaging, after which the telomeres stabilized and remained short. However, the prolonged passaging in ddG caused no observable effects on cell population doubling rates or morphology. Azidothymidine (AZT) caused progressive telomere shortening in some but not all T- and B-cell cultures. Telomerase activity was present in both cell lines and was inhibited in vitro by ddGTP and AZT triphosphate. Prolonged passaging in arabinofuranyl-guanosine, dideoxyinosine (ddI), dideoxyadenosine (ddA), didehydrothymidine (d4T), or phosphonoformic acid (foscarnet) did not cause reproducible telomere shortening or decreased cell growth rates or viabilities. Combining AZT, foscarnet, and/or arabinofuranyl-guanosine with ddG did not significantly augment the effects of ddG alone. Strikingly, with or without inhibitors, telomere lengths were often highly unstable in both cell lines and varied between parallel cell cultures. We propose that telomere lengths in these T- and B-cell lines are determined by both telomerase and telomerase-independent mechanisms.

  18. Verification of ceramic structures

    NARCIS (Netherlands)

    Behar-Lafenetre, S.; Cornillon, L.; Rancurel, M.; Graaf, D. de; Hartmann, P.; Coe, G.; Laine, B.

    2012-01-01

    In the framework of the "Mechanical Design and Verification Methodologies for Ceramic Structures" contract [1] awarded by ESA, Thales Alenia Space has investigated literature and practices in affiliated industries to propose a methodological guideline for verification of ceramic spacecraft and

  19. Clinical application of in vivo treatment delivery verification based on PET/CT imaging of positron activity induced at high energy photon therapy

    Science.gov (United States)

    Janek Strååt, Sara; Andreassen, Björn; Jonsson, Cathrine; Noz, Marilyn E.; Maguire, Gerald Q., Jr.; Näfstadius, Peder; Näslund, Ingemar; Schoenahl, Frederic; Brahme, Anders

    2013-08-01

    The purpose of this study was to investigate in vivo verification of radiation treatment with high energy photon beams using PET/CT to image the induced positron activity. The measurements of the positron activation induced in a preoperative rectal cancer patient and a prostate cancer patient following 50 MV photon treatments are presented. A total dose of 5 and 8 Gy, respectively, were delivered to the tumors. Imaging was performed with a 64-slice PET/CT scanner for 30 min, starting 7 min after the end of the treatment. The CT volume from the PET/CT and the treatment planning CT were coregistered by matching anatomical reference points in the patient. The treatment delivery was imaged in vivo based on the distribution of the induced positron emitters produced by photonuclear reactions in tissue mapped on to the associated dose distribution of the treatment plan. The results showed that spatial distribution of induced activity in both patients agreed well with the delivered beam portals of the treatment plans in the entrance subcutaneous fat regions but less so in blood and oxygen rich soft tissues. For the preoperative rectal cancer patient however, a 2 ± (0.5) cm misalignment was observed in the cranial-caudal direction of the patient between the induced activity distribution and treatment plan, indicating a beam patient setup error. No misalignment of this kind was seen in the prostate cancer patient. However, due to a fast patient setup error in the PET/CT scanner a slight mis-position of the patient in the PET/CT was observed in all three planes, resulting in a deformed activity distribution compared to the treatment plan. The present study indicates that the induced positron emitters by high energy photon beams can be measured quite accurately using PET imaging of subcutaneous fat to allow portal verification of the delivered treatment beams. Measurement of the induced activity in the patient 7 min after receiving 5 Gy involved count rates which were about

  20. Microbial quantities and enzyme activity in soil irrigated with sewage for different lengths of time.

    Science.gov (United States)

    Guo, Xiaoming; Ma, Teng; Chen, Liuzhu; Cui, Yahui; Du, Peng; Liao, Yuan

    2014-12-01

    Sewage is widely used on agricultural soils in peri-urban areas of developing countries to meet shortages of water resource. Although sewage is a good source of plant nutrients, it also increases the heavy metals loads to soils. Microbial responses to these contaminants may serve as early warning indicators of adverse effects of sewage irrigation on soil quality. The purpose of this study was to assess the effect of time of sewage irrigation on soil microbial indicators. Soil samples were collected from seven soil sites (S1-S7) irrigated with 0 years, 16 years, 23 years, 25 years, 27 years, 32 years and 52 years, respectively in Shijiazhuang of China and analyzed. For each soil sample, we determined the quantities of bacteria, fungi and actinomycete, and enzyme activities of urease, sucrase, phosphatase, dehydrogenase and catalase. Our results showed that the soils of S2-S7 irrigated with sewage effluents for different times (ranged between 16 and 52 years) exhibited higher densities of bacteria, actinomycete, urease, sucrase and phosphatase but lower densities of fungi when compared with S1 irrigated with sewage effluents for 0 years. The soil S7 irrigated with sewage effluents for longest times (52 years) contained lowest activities of catalase when compared with the soils of S1-S6. The densities of bacteria (R = 0.877, p Soil fungi quantities and urease, dehydrogenase and catalase activities did not change significantly with irrigation time. This study confirms that sewage irrigation had negative effects on microbial properties including fungi, catalase and dehydrogenase in the long term, so there is a need for continuous monitoring for sustainable soil health.

  1. Load rather than length sensitive feedback contributes to soleus muscle activity during human treadmill walking

    DEFF Research Database (Denmark)

    af Klint, Richard; Mazzaro, Nazarena; Nielsen, Jens Bo

    2010-01-01

    .045), but no significant difference was observed for the SLR (P = 0.13). Similarly, the effect of the BWS was measured on the unload response, i.e., the depression in soleus activity following a plantar-flexion perturbation ( approximately 5.6 degrees, 203-247 degrees/s), quantified over a 50 ms analysis window....... The unload response decreased with decreased load (P > 0.001), but was not significantly affected (P = 0.45) by tizanidine induced depression of the MLR (P = 0.039, n = 6). Since tizanidine is believed to depress the group II afferent pathway, these results are consistent with the idea that force...

  2. To what extent does leg length discrepancy impair motor activity in patients after total hip arthroplasty?

    OpenAIRE

    Benedetti, Maria Grazia; Catani, Fabio; Benedetti, Emanuela; Berti, Lisa; Di Gioia, Annalisa; Giannini, Sandro

    2009-01-01

    The aim of this study was to evaluate the effects of limb lengthening up to 20 mm after THA on symmetry of hip kinematics and kinetics during common activities of daily living. Twenty patients (age range 49–80 years) operated on with Link Lubinus II THA, with lateral access and a mean follow-up of 16 months, were assessed by gait analysis during level walking, stair ascending and descending. The time-distance, hip kinetics and kinematics values were statistically compared between the operated...

  3. Dorsomedial hypothalamic lesions counteract decreases in locomotor activity in male Syrian hamsters transferred from long to short day lengths.

    Science.gov (United States)

    Jarjisian, Stephan G; Butler, Matthew P; Paul, Matthew J; Place, Ned J; Prendergast, Brian J; Kriegsfeld, Lance J; Zucker, Irving

    2015-02-01

    The dorsomedial nucleus (DMN) of the hypothalamus has been implicated in seasonal control of reproduction. Syrian hamsters with DMN lesions, unlike control hamsters, do not undergo testicular regression after transfer from a long day length (14 h of light per day; LD) to a short day length (8 h of light per day; SD). SDs also markedly reduce hamster locomotor activity (LMA). To assess whether the DMN is a component of the neural circuitry that mediates seasonal variation in LMA, neurologically intact males (controls) and hamsters that had sustained lesions of the DMN (DMNx) were housed in an LD or SD photoperiod for 26 weeks. DMNx that prevented testicular regression counteracted decreases in LMA during 8 to10 weeks of SD treatment; steroid-independent effects of SDs did not override high levels of LMA in DMNx males. As in previous studies, testosterone (T) restoration increased LMA in LD but not SD castrated control males. In the present study, T also failed to increase LMA in SD-DMNx hamsters. The DMN is not necessary to maintain decreased responsiveness of locomotor activity systems to T in SDs, which presumably is mediated by other central nervous system androgen target tissues. Finally, DMNx did not interfere with the spontaneous increase in LMA exhibited by photorefractory hamsters after 26 weeks of SD treatment. We propose that DMN is an essential part of the substrate that mediates seasonal decreases in LMA as day length decreases but is not required to sustain decreased SD responsiveness to T or for development of refractoriness to SDs. © 2014 The Author(s).

  4. TLR8 activation and inhibition by guanosine analogs in RNA: Importance of functional groups and chain length.

    Science.gov (United States)

    Hu, Tiannan; Suter, Scott R; Mumbleau, Madeline M; Beal, Peter A

    2018-01-01

    Toll-like receptor 8 (TLR8) is an important component of the human innate immune system that recognizes single stranded RNA (ssRNA). Recent X-ray crystal structures of TLR8 bound to ssRNA revealed a previously unrecognized binding site for a 5'-UpG-3' dinucleotide. Here we use an atomic mutagenesis strategy coupled with a cellular TLR8 activation assay to probe the importance of specific functional groups present on the guanine base in RNA-mediated receptor agonism and antagonism. Results from RNA analogs containing 7-deazaguanosine, 2-aminopurine and inosine confirm the importance of guanine N7, O6 and N2, respectively, in TLR8 activation. Nevertheless, these RNAs each retained TLR8 antagonism activity. RNA containing 7-deaza-8-azainosine (7d8aI) was prepared from a novel phosphoramidite and found to be a weaker TLR8 activator than guanosine-containing RNA. However, 7d8aI-containing RNA also retained TLR8 antagonism activity indicating that removal of multiple TLR8 H-bonding sites on guanine is insufficient for blocking TLR8 antagonism by guanine-containing RNA. We also identified an oligoribonucleotide length dependence on both TLR8 activation and antagonism. These studies extend our understanding of the effects of nucleobase modification on immune stimulation and will inform the design of novel RNA-based therapeutics. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. On the role of code comparisons in verification and validation.

    Energy Technology Data Exchange (ETDEWEB)

    Oberkampf, William Louis; Trucano, Timothy Guy; Pilch, Martin M.

    2003-08-01

    This report presents a perspective on the role of code comparison activities in verification and validation. We formally define the act of code comparison as the Code Comparison Principle (CCP) and investigate its application in both verification and validation. One of our primary conclusions is that the use of code comparisons for validation is improper and dangerous. We also conclude that while code comparisons may be argued to provide a beneficial component in code verification activities, there are higher quality code verification tasks that should take precedence. Finally, we provide a process for application of the CCP that we believe is minimal for achieving benefit in verification processes.

  6. Linker length and flexibility induces new cellobiohydrolase activity of PoCel6A from Penicillium oxalicum.

    Science.gov (United States)

    Gao, Le; Wang, Lushan; Jiang, Xukai; Qu, Yinbo

    2015-06-01

    In a previous study, a novel cellobiohydrolase, PoCel6A, with new enzymatic activity against p-nitrophenyl-β-D-cellobioside (pNPC), was purified from Penicillium oxalicum. The cellulose-binding module and catalytic domain of PoCel6A showed a high degree of sequence similarity with other fungal Cel6As. However, PoCel6A had 11 more amino acids in the linker region than other Cel6As. To evaluate the relationship between the longer linker of PoCel6A and its enzymatic activity, 11 amino acids were deleted from the linker region of PoCel6A. The shortened PoCel6A linker nullified the enzymatic activity against pNPC but dramatically increased the enzyme's capacity for crystalline cellulose degradation. The shortened linker segment appeared to have no effect on the secondary structural conformation of PoCel6A. Another variant (PoCel6A-6pro) with six consecutive proline residues in the interdomain linker had a higher rigid linker, and no enzymatic activity was observed against soluble and insoluble substrate. The flexibility of the linker had an important function in the formation of active cellulase. The length and flexibility of the linker is clearly able to modify the function of PoCel6A and induce new characteristics of Cel6A. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Flame Length

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Flame length was modeled using FlamMap, an interagency fire behavior mapping and analysis program that computes potential fire behavior characteristics. The tool...

  8. Weather, day length and physical activity in older adults: Cross-sectional results from the European Prospective Investigation into Cancer and Nutrition (EPIC Norfolk Cohort.

    Directory of Open Access Journals (Sweden)

    Yu-Tzu Wu

    Full Text Available A wide range of environmental factors have been related to active ageing, but few studies have explored the impact of weather and day length on physical activity in older adults. We investigate the cross-sectional association between weather conditions, day length and activity in older adults using a population-based cohort in England, the European Prospective Investigation into Cancer and Nutrition (EPIC Norfolk study.Physical activity was measured objectively over 7 days using an accelerometer and this was used to calculate daily total physical activity (counts per minute, daily minutes of sedentary behaviour and light, moderate and vigorous physical activity (LMVPA. Day length and two types of weather conditions, precipitation and temperature, were obtained from a local weather station. The association between these variables and physical activity was examined by multilevel first-order autoregressive modelling.After adjusting for individual factors, short day length and poor weather conditions, including high precipitation and low temperatures, were associated with up to 10% lower average physical activity (p<0.01 and 8 minutes less time spent in LMVPA but 15 minutes more sedentary time, compared to the best conditions.Day length and weather conditions appear to be an important factor related to active ageing. Future work should focus on developing potential interventions to reduce their impact on physical activity behaviours in older adults.

  9. On power consumption issues in FIR filters with application to communication receivers: complexity, word length, and switching activity

    Energy Technology Data Exchange (ETDEWEB)

    Havashki, Asghar

    2009-10-15

    channel estimation must be upheld, in particular at medium-to-high Channel Signal to Noise Ratios (CSNR). Furthermore, reducing the power consumption through word-length optimization, when realizing such estimators, is an attractive approach. Due to the characteristics of the input signal to such estimators, a special treatment of channel estimation error due to quantization of estimator filter coefficients is needed. In this thesis we investigate the impact of finite coefficient word length on channel estimator performance. A theoretical analysis of the increase in channel estimation error due to quantization of estimator coefficients is performed, and the behavior of this error in different fading environments and for different filter orders is studied. The power consumed in a channel estimator is also influenced by the switching activity in the input signal of the estimator. Characterizing the switching activity in the input signal, including how this activity changes in different environments, e.g., in the presence of noise, is a subject of the work performed in this thesis. In this study we give an expression for direct calculation of the correlation coefficient for the most significant bit in a signal, using the word-level correlation coefficient. We also derive expressions for accurately calculating the variance and word-level correlation coefficient for a correlated signal, when an additional noise of a given variance is added to the signal. This can be used to estimate the bit-level switching activity in a signal in the presence of noise, based on the Dual Bit Type (DBT) method. The impact the additional noise has on the switching activity of a correlated signal has also been studied. These results make it possible for a designer to model the actual input switching activity in different real life noisy environments, enabling realistic power consumption estimation. A study on switching activity reduction in estimator filters using a coefficient reordering method

  10. Physics Verification Overview

    Energy Technology Data Exchange (ETDEWEB)

    Doebling, Scott William [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-09-12

    The purpose of the verification project is to establish, through rigorous convergence analysis, that each ASC computational physics code correctly implements a set of physics models and algorithms (code verification); Evaluate and analyze the uncertainties of code outputs associated with the choice of temporal and spatial discretization (solution or calculation verification); and Develop and maintain the capability to expand and update these analyses on demand. This presentation describes project milestones.

  11. Baghouse filtration products verification

    Energy Technology Data Exchange (ETDEWEB)

    Mycock, J.C.; Turner, J.H.; VanOsdell, D.W.; Farmer, J.R.; Brna, T.G.

    1998-11-01

    The paper introduces EPA`s Air Pollution Control Technology Verification (APCT) program and then focuses on the immediate objective of the program: laboratory performance verification of cleanable filter media intended for the control of fine particulate emissions. Data collected during the laboratory verification testing, which simulates operation in full-scale fabric filters, will be used to show expected performance for collection of particles {le} 2.5 micrometers in diameter.

  12. Adsorption and biodegradation of 2-chlorophenol by mixed culture using activated carbon as a supporting medium-reactor performance and model verification

    Science.gov (United States)

    Lin, Yen-Hui

    2017-11-01

    A non-steady-state mathematical model system for the kinetics of adsorption and biodegradation of 2-chlorophenol (2-CP) by attached and suspended biomass on activated carbon process was derived. The mechanisms in the model system included 2-CP adsorption by activated carbon, 2-CP mass transport diffusion in biofilm, and biodegradation by attached and suspended biomass. Batch kinetic tests were performed to determine surface diffusivity of 2-CP, adsorption parameters for 2-CP, and biokinetic parameters of biomass. Experiments were conducted using a biological activated carbon (BAC) reactor system with high recycled rate to approximate a completely mixed flow reactor for model verification. Concentration profiles of 2-CP by model predictions indicated that biofilm bioregenerated the activated carbon by lowering the 2-CP concentration at the biofilm-activated carbon interface as the biofilm grew thicker. The removal efficiency of 2-CP by biomass was approximately 98.5% when 2-CP concentration in the influent was around 190.5 mg L-1 at a steady-state condition. The concentration of suspended biomass reached up to about 25.3 mg L-1 while the thickness of attached biomass was estimated to be 636 μm at a steady-state condition by model prediction. The experimental results agree closely with the results of the model predictions.

  13. Adsorption and biodegradation of 2-chlorophenol by mixed culture using activated carbon as a supporting medium-reactor performance and model verification

    Science.gov (United States)

    Lin, Yen-Hui

    2016-12-01

    A non-steady-state mathematical model system for the kinetics of adsorption and biodegradation of 2-chlorophenol (2-CP) by attached and suspended biomass on activated carbon process was derived. The mechanisms in the model system included 2-CP adsorption by activated carbon, 2-CP mass transport diffusion in biofilm, and biodegradation by attached and suspended biomass. Batch kinetic tests were performed to determine surface diffusivity of 2-CP, adsorption parameters for 2-CP, and biokinetic parameters of biomass. Experiments were conducted using a biological activated carbon (BAC) reactor system with high recycled rate to approximate a completely mixed flow reactor for model verification. Concentration profiles of 2-CP by model predictions indicated that biofilm bioregenerated the activated carbon by lowering the 2-CP concentration at the biofilm-activated carbon interface as the biofilm grew thicker. The removal efficiency of 2-CP by biomass was approximately 98.5% when 2-CP concentration in the influent was around 190.5 mg L-1 at a steady-state condition. The concentration of suspended biomass reached up to about 25.3 mg L-1 while the thickness of attached biomass was estimated to be 636 μm at a steady-state condition by model prediction. The experimental results agree closely with the results of the model predictions.

  14. Verification and Validation of Flight Critical Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Verification and Validation is a multi-disciplinary activity that encompasses elements of systems engineering, safety, software engineering and test. The elements...

  15. Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2.

    Science.gov (United States)

    Yin, Yaling; Wang, Yali; Gao, Di; Ye, Jinwang; Wang, Xin; Fang, Lin; Wu, Dongqin; Pi, Guilin; Lu, Chengbiao; Zhou, Xin-Wen; Yang, Ying; Wang, Jian-Zhi

    2016-06-09

    Cholinergic impairments and tau accumulation are hallmark pathologies in sporadic Alzheimer's disease (AD), however, the intrinsic link between tau accumulation and cholinergic deficits is missing. Here, we found that overexpression of human wild-type full-length tau (termed hTau) induced a significant reduction of α4 subunit of nicotinic acetylcholine receptors (nAChRs) with an increased cleavage of the receptor producing a ~55kDa fragment in primary hippocampal neurons and in the rat brains, meanwhile, the α4 nAChR currents decreased. Further studies demonstrated that calpains, including calpain-1 and calpain-2, were remarkably activated with no change of caspase-3, while simultaneous suppression of calpain-2 by selective calpain-2 inhibitor but not calpain-1 attenuated the hTau-induced degradation of α4 nAChR. Finally, we demonstrated that hTau accumulation increased the basal intracellular calcium level in primary hippocampal neurons. We conclude that the hTau accumulation inhibits nAChRs α4 by activating calpain-2. To our best knowledge, this is the first evidence showing that the intracellular accumulation of tau causes cholinergic impairments.

  16. Weather, day length and physical activity in older adults: Cross-sectional results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Norfolk Cohort.

    Science.gov (United States)

    Wu, Yu-Tzu; Luben, Robert; Wareham, Nicholas; Griffin, Simon; Jones, Andy P

    2017-01-01

    A wide range of environmental factors have been related to active ageing, but few studies have explored the impact of weather and day length on physical activity in older adults. We investigate the cross-sectional association between weather conditions, day length and activity in older adults using a population-based cohort in England, the European Prospective Investigation into Cancer and Nutrition (EPIC) Norfolk study. Physical activity was measured objectively over 7 days using an accelerometer and this was used to calculate daily total physical activity (counts per minute), daily minutes of sedentary behaviour and light, moderate and vigorous physical activity (LMVPA). Day length and two types of weather conditions, precipitation and temperature, were obtained from a local weather station. The association between these variables and physical activity was examined by multilevel first-order autoregressive modelling. After adjusting for individual factors, short day length and poor weather conditions, including high precipitation and low temperatures, were associated with up to 10% lower average physical activity (pweather conditions appear to be an important factor related to active ageing. Future work should focus on developing potential interventions to reduce their impact on physical activity behaviours in older adults.

  17. Verification Account Management System (VAMS)

    Data.gov (United States)

    Social Security Administration — The Verification Account Management System (VAMS) is the centralized location for maintaining SSA's verification and data exchange accounts. VAMS account management...

  18. Global-scale pattern of peatland Sphagnum growth driven by photosynthetically active radiation and growing season length

    Directory of Open Access Journals (Sweden)

    Z. Yu

    2012-07-01

    Full Text Available High-latitude peatlands contain about one third of the world's soil organic carbon, most of which is derived from partly decomposed Sphagnum (peat moss plants. We conducted a meta-analysis based on a global data set of Sphagnum growth measurements collected from published literature to investigate the effects of bioclimatic variables on Sphagnum growth. Analysis of variance and general linear models were used to relate Sphagnum magellanicum and S. fuscum growth rates to photosynthetically active radiation integrated over the growing season (PAR0 and a moisture index. We found that PAR0 was the main predictor of Sphagnum growth for the global data set, and effective moisture was only correlated with moss growth at continental sites. The strong correlation between Sphagnum growth and PAR0 suggests the existence of a global pattern of growth, with slow rates under cool climate and short growing seasons, highlighting the important role of growing season length in explaining peatland biomass production. Large-scale patterns of cloudiness during the growing season might also limit moss growth. Although considerable uncertainty remains over the carbon balance of peatlands under a changing climate, our results suggest that increasing PAR0 as a result of global warming and lengthening growing seasons, without major change in cloudiness, could promote Sphagnum growth. Assuming that production and decomposition have the same sensitivity to temperature, this enhanced growth could lead to greater peat-carbon sequestration, inducing a negative feedback to climate change.

  19. Global-scale pattern of peatland Sphagnum growth driven by photosynthetically active radiation and growing season length

    Science.gov (United States)

    Loisel, J.; Gallego-Sala, A. V.; Yu, Z.

    2012-07-01

    High-latitude peatlands contain about one third of the world's soil organic carbon, most of which is derived from partly decomposed Sphagnum (peat moss) plants. We conducted a meta-analysis based on a global data set of Sphagnum growth measurements collected from published literature to investigate the effects of bioclimatic variables on Sphagnum growth. Analysis of variance and general linear models were used to relate Sphagnum magellanicum and S. fuscum growth rates to photosynthetically active radiation integrated over the growing season (PAR0) and a moisture index. We found that PAR0 was the main predictor of Sphagnum growth for the global data set, and effective moisture was only correlated with moss growth at continental sites. The strong correlation between Sphagnum growth and PAR0 suggests the existence of a global pattern of growth, with slow rates under cool climate and short growing seasons, highlighting the important role of growing season length in explaining peatland biomass production. Large-scale patterns of cloudiness during the growing season might also limit moss growth. Although considerable uncertainty remains over the carbon balance of peatlands under a changing climate, our results suggest that increasing PAR0 as a result of global warming and lengthening growing seasons, without major change in cloudiness, could promote Sphagnum growth. Assuming that production and decomposition have the same sensitivity to temperature, this enhanced growth could lead to greater peat-carbon sequestration, inducing a negative feedback to climate change.

  20. Verification is experimentation!

    NARCIS (Netherlands)

    Brinksma, Hendrik

    2001-01-01

    The formal verification of concurrent systems is usually seen as an example par excellence of the application of mathematical methods to computer science. Although the practical application of such verification methods will always be limited by the underlying forms of combinatorial explosion, recent

  1. Verification Is Experimentation!

    NARCIS (Netherlands)

    Brinksma, Hendrik

    2000-01-01

    the formal verification of concurrent systems is usually seen as an example par excellence of the application of mathematical methods to computer science. although the practical application of such verification methods will always be limited by the underlying forms of combinatorial explosion, recent

  2. Environmental technology verification methods

    CSIR Research Space (South Africa)

    Szewczuk, S

    2016-03-01

    Full Text Available the performance of innovative environmental technologies can be verified by qualified third parties called "Verification Bodies". The "Statement of Verification" delivered at the end of the ETV process can be used as evidence that the claims made about...

  3. Moderate-duration static stretch reduces active and passive plantar flexor moment but not Achilles tendon stiffness or active muscle length.

    Science.gov (United States)

    Kay, Anthony D; Blazevich, Anthony J

    2009-04-01

    The effects of static stretch on muscle and tendon mechanical properties and muscle activation were studied in fifteen healthy human volunteers. Peak active and passive moment data were recorded during plantar flexion trials on an isokinetic dynamometer. Electromyography (EMG) monitoring of the triceps surae muscles, real-time motion analysis of the lower leg, and ultrasound imaging of the Achilles-medial gastrocnemius muscle-tendon junction were simultaneously conducted. Subjects performed three 60-s static stretches before being retested 2 min and 30 min poststretch. There were three main findings in the present study. First, peak concentric moment was significantly reduced after stretch; 60% of the deficit recovered 30 min poststretch. This was accompanied by, and correlated with (r = 0.81; P stretch and at 30 min poststretch; however, no change in tendon stiffness was detected. Third, passive joint moment was significantly reduced after stretch, and this was accompanied by significant reductions in medial gastrocnemius passive muscle stiffness; both measures fully recovered by 30 min poststretch. These data indicate that the stretching protocol used in this study induced losses in concentric moment that were accompanied by, and related to, reductions in neuromuscular activity, but they were not associated with alterations in tendon stiffness or shorter muscle operating length. Reductions in passive moment were associated with reductions in muscle stiffness, whereas tendon mechanics were unaffected by the stretch. Importantly, the impact on mechanical properties and neuromuscular activity was minimal at 30 min poststretch.

  4. Guidelines for Formal Verification Systems

    Science.gov (United States)

    1989-04-01

    This document explains the requirements for formal verification systems that are candidates for the NCSC’s Endorsed Tools List (ETL). This document...is primarily intended for developers of verification systems to use in the development of production-quality formal verification systems. It explains...the requirements and the process used to evaluate formal verification systems submitted to the NCSC for endorsement.

  5. PCB153 reduces telomerase activity and telomere length in immortalized human skin keratinocytes (HaCaT) but not in human foreskin keratinocytes (NFK)

    Energy Technology Data Exchange (ETDEWEB)

    Senthilkumar, P.K. [Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA (United States); Robertson, L.W. [Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA (United States); Department of Occupational and Environmental Health, The University of Iowa, Iowa City, IA (United States); Ludewig, G., E-mail: Gabriele-ludewig@uiowa.edu [Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA (United States); Department of Occupational and Environmental Health, The University of Iowa, Iowa City, IA (United States)

    2012-02-15

    Polychlorinated biphenyls (PCBs), ubiquitous environmental pollutants, are characterized by long term-persistence in the environment, bioaccumulation, and biomagnification in the food chain. Exposure to PCBs may cause various diseases, affecting many cellular processes. Deregulation of the telomerase and the telomere complex leads to several biological disorders. We investigated the hypothesis that PCB153 modulates telomerase activity, telomeres and reactive oxygen species resulting in the deregulation of cell growth. Exponentially growing immortal human skin keratinocytes (HaCaT) and normal human foreskin keratinocytes (NFK) were incubated with PCB153 for 48 and 24 days, respectively, and telomerase activity, telomere length, superoxide level, cell growth, and cell cycle distribution were determined. In HaCaT cells exposure to PCB153 significantly reduced telomerase activity, telomere length, cell growth and increased intracellular superoxide levels from day 6 to day 48, suggesting that superoxide may be one of the factors regulating telomerase activity, telomere length and cell growth compared to untreated control cells. Results with NFK cells showed no shortening of telomere length but reduced cell growth and increased superoxide levels in PCB153-treated cells compared to untreated controls. As expected, basal levels of telomerase activity were almost undetectable, which made a quantitative comparison of treated and control groups impossible. The significant down regulation of telomerase activity and reduction of telomere length by PCB153 in HaCaT cells suggest that any cell type with significant telomerase activity, like stem cells, may be at risk of premature telomere shortening with potential adverse health effects for the affected organism. -- Highlights: ► Human immortal (HaCaT) and primary (NFK) keratinocytes were exposed to PCB153. ► PCB153 significantly reduced telomerase activity and telomere length in HaCaT. ► No effect on telomere length and

  6. Voltage verification unit

    Science.gov (United States)

    Martin, Edward J [Virginia Beach, VA

    2008-01-15

    A voltage verification unit and method for determining the absence of potentially dangerous potentials within a power supply enclosure without Mode 2 work is disclosed. With this device and method, a qualified worker, following a relatively simple protocol that involves a function test (hot, cold, hot) of the voltage verification unit before Lock Out/Tag Out and, and once the Lock Out/Tag Out is completed, testing or "trying" by simply reading a display on the voltage verification unit can be accomplished without exposure of the operator to the interior of the voltage supply enclosure. According to a preferred embodiment, the voltage verification unit includes test leads to allow diagnostics with other meters, without the necessity of accessing potentially dangerous bus bars or the like.

  7. Standard Verification System (SVS)

    Data.gov (United States)

    Social Security Administration — SVS is a mainframe program that accesses the NUMIDENT to perform SSN verifications. This program is called by SSA Internal applications to verify SSNs. There is also...

  8. SSN Verification Service

    Data.gov (United States)

    Social Security Administration — The SSN Verification Service is used by Java applications to execute the GUVERF02 service using the WebSphere/CICS Interface. It accepts several input data fields...

  9. Bacterial membrane activity of a-peptide/b-peptoid chimeras: Influence of amino acid composition and chain length on the activity against different bacterial strains

    DEFF Research Database (Denmark)

    Hein-Kristensen, Line; Knapp, Kolja M; Franzyk, Henrik

    2011-01-01

    BACKGROUND: Characterization and use of antimicrobial peptides (AMPs) requires that their mode of action is determined. The interaction of membrane-active peptides with their target is often established using model membranes, however, the actual permeabilization of live bacterial cells and subseq...... of the bacterial cell envelope, and the outer membrane may act as a barrier in Gram-negative bacteria. The tolerance of S. marcescens to chimeras may be due to differences in the composition of the lipopolysaccharide layer also responsible for its resistance to polymyxin B.......BACKGROUND: Characterization and use of antimicrobial peptides (AMPs) requires that their mode of action is determined. The interaction of membrane-active peptides with their target is often established using model membranes, however, the actual permeabilization of live bacterial cells...... and subsequent killing is usually not tested. In this report, six α-peptide/β-peptoid chimeras were examined for the effect of amino acid/peptoid substitutions and chain length on the membrane perturbation and subsequent killing of food-borne and clinical bacterial isolates. RESULTS: All six AMP analogues...

  10. Increased in vitro glial fibrillary acidic protein expression, telomerase activity, and telomere length after productive human immunodeficiency virus-1 infection in murine astrocytes.

    Science.gov (United States)

    Ojeda, Diego; López-Costa, Juan José; Sede, Mariano; López, Ester María; Berria, María Isabel; Quarleri, Jorge

    2014-02-01

    Although HIV-associated neurocognitive disorders (HAND) result from injury and loss of neurons, productive infection routinely takes place in cells of macrophage lineage. In such a complex context, astrocytosis induced by local chemokines/cytokines is one of the hallmarks of HIV neuropathology. Whether this sustained astrocyte activation is able to alter telomere-aging process is unknown. We hypothesized that interaction of HIV with astrocytes may impact astrocyte telomerase activity (TA) and telomere length in a scenario of astrocytic activation measured by expression of glial fibrillary acidic protein (GFAP). To test this hypothesis, cultured murine astrocytes were challenged with pseudotyped HIV/vesicular stomatitis virus (HIV/VSV) to circumvent the absence of viral receptors; and GFAP, telomerase activity, and telomere length were quantified. As an early and transient event after HIV infection, both TA activity and telomere length were significantly augmented (P < 0.001). Later, a strong negative correlation (-0.8616, P < 0.0001) between virus production and telomerase activity was demonstrated. Once HIV production had reached a peak (7 dpi), the TA decreased, showing levels similar to those of noninfected cells. In contrast, the astrocyte became activated, exhibiting significantly increased levels of GFAP expression directly related to the level of HIV/VSV replication (P < 0.0001). Our results suggest that HIV-infected astrocytes exhibit early disturbance in their cellular functions, such as telomerase activity and telomere length, that may attenuate cell proliferation and enhance the astrocyte dysregulation, contributing to HIV neuropathogenesis. Understanding the mechanisms involved in HIV-mediated persistence by altering the telomere-related aging processes could aid in the development of therapeutic modalities for neurological complications of HIV infection. Copyright © 2013 Wiley Periodicals, Inc.

  11. Design verification and fabrication of active control systems for the DAST ARW-2 high aspect ratio wing, part 1

    Science.gov (United States)

    Mcgehee, C. R.

    1986-01-01

    A study was conducted under Drones for Aerodynamic and Structural Testing (DAST) program to accomplish the final design and hardware fabrication for four active control systems compatible with and ready for installation in the NASA Aeroelastic Research Wing No. 2 (ARW-2) and Firebee II drone flight test vehicle. The wing structure was designed so that Active Control Systems (ACS) are required in the normal flight envelope by integrating control system design with aerodynamics and structure technologies. The DAST ARW-2 configuration uses flutter suppression, relaxed static stability, and gust and maneuver load alleviation ACS systems, and an automatic flight control system. Performance goals and criteria were applied to individual systems and the systems collectively to assure that vehicle stability margins, flutter margins, flying qualities and load reductions are achieved.

  12. Development and verification of signal processing system of avalanche photo diode for the active shields onboard ASTRO-H

    Energy Technology Data Exchange (ETDEWEB)

    Ohno, M., E-mail: ohno@hep01.hepl.hiroshima-u.ac.jp [Department of Physical Sciences, Hiroshima University, Hiroshima 739-8526 (Japan); Kawano, T.; Edahiro, I.; Shirakawa, H.; Ohashi, N.; Okada, C.; Habata, S.; Katsuta, J.; Tanaka, Y.; Takahashi, H.; Mizuno, T.; Fukazawa, Y. [Department of Physical Sciences, Hiroshima University, Hiroshima 739-8526 (Japan); Murakami, H.; Kobayashi, S.; Miyake, K.; Ono, K.; Kato, Y.; Furuta, Y.; Murota, Y.; Okuda, K. [Department of Physics, University of Tokyo, Tokyo 113-0033 (Japan); and others

    2016-09-21

    The hard X-ray Imager and Soft Gamma-ray Detector onboard ASTRO-H demonstrate high sensitivity to hard X-ray (5–80 keV) and soft gamma-rays (60–600 keV), respectively. To reduce the background, both instruments are actively shielded by large, thick Bismuth Germanate scintillators. We have developed the signal processing system of the avalanche photodiode in the BGO active shields and have demonstrated its effectiveness after assembly in the flight model of the HXI/SGD sensor and after integration into the satellite. The energy threshold achieved is about 150 keV and anti-coincidence efficiency for cosmic-ray events is almost 100%. Installed in the BGO active shield, the developed signal processing system successfully reduces the room background level of the main detector. - Highlights: • A detail of development of signal processing system for ASTRO-H is presented. • Digital filer with FPGA instead of discrete analog circuit is applied. • Expected performance is verified after integration of the satellite.

  13. Embedded software verification and debugging

    CERN Document Server

    Winterholer, Markus

    2017-01-01

    This book provides comprehensive coverage of verification and debugging techniques for embedded software, which is frequently used in safety critical applications (e.g., automotive), where failures are unacceptable. Since the verification of complex systems needs to encompass the verification of both hardware and embedded software modules, this book focuses on verification and debugging approaches for embedded software with hardware dependencies. Coverage includes the entire flow of design, verification and debugging of embedded software and all key approaches to debugging, dynamic, static, and hybrid verification. This book discusses the current, industrial embedded software verification flow, as well as emerging trends with focus on formal and hybrid verification and debugging approaches. Includes in a single source the entire flow of design, verification and debugging of embedded software; Addresses the main techniques that are currently being used in the industry for assuring the quality of embedded softw...

  14. Augmented telomerase activity, reduced telomere length and the presence of alternative lengthening of telomere in renal cell carcinoma: plausible predictive and diagnostic markers.

    Science.gov (United States)

    Pal, Deeksha; Sharma, Ujjawal; Khajuria, Ragini; Singh, Shrawan Kumar; Kakkar, Nandita; Prasad, Rajendra

    2015-05-15

    In this study, we analyzed 100 cases of renal cell carcinoma (RCC) for telomerase activity, telomere length and alternative lengthening of telomeres (ALT) using the TRAP assay, TeloTTAGGG assay kit and immunohistochemical analysis of ALT associated promyelocytic leukemia (PML) bodies respectively. A significantly higher (P=0.000) telomerase activity was observed in 81 cases of RCC which was correlated with clinicopathological features of tumor for instance, stage (P=0.008) and grades (P=0.000) but not with the subtypes of RCC (P = 0.355). Notwithstanding, no correlation was found between telomerase activity and subtypes of RCC. Strikingly, the telomere length was found to be significantly shorter in RCC (P=0.000) to that of corresponding normal renal tissues and it is well correlated with grades (P=0.016) but not with stages (P=0.202) and subtypes (P=0.669) of RCC. In this study, telomere length was also negatively correlated with the age of patients (r(2)=0.528; P=0.000) which supports the notion that it could be used as a marker for biological aging. ALT associated PML bodies containing PML protein was found in telomerase negative cases of RCC. It suggests the presence of an ALT pathway mechanism to maintain the telomere length in telomerase negative RCC tissues which was associated with high stages of RCC, suggesting a prevalent mechanism for telomere maintenance in high stages. In conclusion, the telomerase activity and telomere length can be used as a diagnostic as well as a predictive marker in RCC. The prevalence of ALT mechanism in high stages of RCC is warranted for the development of anti-ALT inhibitors along with telomerase inhibitor against RCC as a therapeutic approach. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor ?4 via activating calpain-2

    OpenAIRE

    Yaling Yin; Yali Wang; Di Gao; Jinwang Ye; Xin Wang; Lin Fang; Dongqin Wu; Guilin Pi; Chengbiao Lu; Xin-Wen Zhou; Ying Yang; Jian-Zhi Wang

    2016-01-01

    Cholinergic impairments and tau accumulation are hallmark pathologies in sporadic Alzheimer?s disease (AD), however, the intrinsic link between tau accumulation and cholinergic deficits is missing. Here, we found that overexpression of human wild-type full-length tau (termed hTau) induced a significant reduction of ?4 subunit of nicotinic acetylcholine receptors (nAChRs) with an increased cleavage of the receptor producing a ~55kDa fragment in primary hippocampal neurons and in the rat brains...

  16. Automatic adjustment of cycle length and aeration time for improved nitrogen removal in an alternating activated sludge process

    DEFF Research Database (Denmark)

    Isaacs, Steven Howard

    1997-01-01

    The paper examines the nitrogen dynamics in the alternating BIODENITRO and BIODENIPHO processes with a focus on two control handles influencing now scheduling and aeration: the cycle length and the ammonia concentration at which a nitrifying period is terminated. A steady state analysis examining...... on a cycle by cycle single variable optimization rather than a more difficult multivariable optimization over a longer time horizon. Copyright (C) 1996 IAWQ....

  17. Multispectral reflectance imaging of brain activation in rodents: methodological study of the differential path length estimations and first in vivo recordings in the rat olfactory bulb

    Science.gov (United States)

    Renaud, Rémi; Martin, Claire; Gurden, Hirac; Pain, Frédéric

    2012-01-01

    Dynamic maps of relative changes in blood volume and oxygenation following brain activation are obtained using multispectral reflectance imaging. The technique relies on optical absorption modifications linked to hemodynamic changes. The relative variation of hemodynamic parameters can be quantified using the modified Beer-Lambert Law if changes in reflected light intensities are recorded at two wavelengths or more and the differential path length (DP) is known. The DP is the mean path length in tissues of backscattered photons and varies with wavelength. It is usually estimated using Monte Carlo simulations in simplified semi-infinite homogeneous geometries. Here we consider the use of multilayered models of the somatosensory cortex (SsC) and olfactory bulb (OB), which are common physiological models of brain activation. Simulations demonstrate that specific DP estimation is required for SsC and OB, specifically for wavelengths above 600 nm. They validate the hypothesis of a constant path length during activation and show the need for specific DP if imaging is performed in a thinned-skull preparation. The first multispectral reflectance imaging data recorded in vivo during OB activation are presented, and the influence of DP on the hemodynamic parameters and the pattern of oxymetric changes in the activated OB are discussed.

  18. Development and experimental verification of a robust active noise control system for a diesel engine in submarines

    Science.gov (United States)

    Sachau, D.; Jukkert, S.; Hövelmann, N.

    2016-08-01

    This paper presents the development and experimental validation of an ANC (active noise control)-system designed for a particular application in the exhaust line of a submarine. Thereby, tonal components of the exhaust noise in the frequency band from 75 Hz to 120 Hz are reduced by more than 30 dB. The ANC-system is based on the feedforward leaky FxLMS-algorithm. The observability of the sound pressure in standing wave field is ensured by using two error microphones. The noninvasive online plant identification method is used to increase the robustness of the controller. Online plant identification is extended by a time-varying convergence gain to improve the performance in the presence of slight error in the frequency of the reference signal.

  19. Investigating the role of chain and linker length on the catalytic activity of an H 2 production catalyst containing a β-hairpin peptide

    Energy Technology Data Exchange (ETDEWEB)

    Reback, Matthew L.; Ginovska, Bojana; Buchko, Garry W.; Dutta, Arnab; Priyadarshani, Nilusha; Kier, Brandon L.; Helm, Monte L.; Raugei, Simone; Shaw, Wendy J.

    2016-06-02

    Building on our recent report of an active H2 production catalyst [Ni(PPh2NProp-peptide)2]2+ (Prop=para-phenylpropionic acid, peptide (R10)=WIpPRWTGPR-NH2, p=D-proline, and P2N=1-aza-3,6-diphosphacycloheptane) that contains structured -hairpin peptides, here we investigate how H2 production is effected by: (1) the length of the hairpin (eight or ten residues) and (2) limiting the flexibility between the peptide and the core complex by altering the length of the linker: para-phenylpropionic acid (three carbons) or para-benzoic acid (one carbon). Reduction of the peptide chain length from ten to eight residues increases or maintains the catalytic current for H2 production for all complexes, suggesting a non-productive steric interaction at longer peptide lengths. While the structure of the hairpin appears largely intact for the complexes, NMR data are consistent with differences in dynamic behavior which may contribute to the observed differences in catalytic activity. Molecular dynamics simulations demonstrate that complexes with a one-carbon linker have the desired effect of restricting the motion of the hairpin relative to the complex; however, the catalytic currents are significantly reduced compared to complexes containing a three-carbon linker as a result of the electron withdrawing nature of the -COOH group. These results demonstrate the complexity and interrelated nature of the outer coordination sphere on catalysis.

  20. Liposome encapsulation of lipophilic N-alkyl-propanediamine platinum complexes: impact on their cytotoxic activity and influence of the carbon chain length

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Heveline; Fontes, Ana Paula S. [Universidade Federal de Juiz de Fora (UFJF), MG (Brazil). Dept. de Quimica; Lopes, Miriam Teresa P. [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Farmacologia; Frezard, Frederic, E-mail: frezard@icb.ufmg.b [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Fisiologia e Biofisica

    2010-07-01

    Antitumor platinum(II) complexes derived from N-alkyl-propanediamine differing in the length of their carbon chain (C8, C10, C12 and C14) were incorporated in liposomes and the cytotoxic activity of these formulations was evaluated against tumor (A{sub 549}, MDA-MB-231, B16-F1 and B16-F10) and non-tumor (BHK-21 and CHO) cell lines. Stable and monodisperse liposome suspensions incorporating the platinum complexes were obtained from the lipid composition consisting of distearoyl-sn-glycero-3-phosphocholine, cholesterol and 1,2-distearoyl-sn-glycero- 3-phosphoethanolamine-N-(methoxy(polyethylene glycol)-2000) at 5:3:0.3 molar ratio. The entrapment efficiency (EE%) of the platinum complexes in liposomes increased with the carbon chain length. EE% was higher than 80% in C12- and C14-derivatives. The effect of liposome encapsulation on the cytotoxic activity of the complexes was found to depend on the carbon chain length. These data indicate that the highest drug bioavailability from liposome formulations was achieved with the complex showing intermediate carbon chain length and partition between the liposome membrane and aqueous phase. (author)

  1. Verification of biological activity of irradiated Sopoongsan, an oriental medicinal prescription, for industrial application of functional cosmetic material

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jin-Young; Park, Tae-Soon; Ho Son, Jun [Department of Cosmeceutical Science, Daegu Haany University, Kyungsan 712-715 (Korea, Republic of); Jo, Cheorun [Department of Animal Science and Biotechnology, Chungnam National University, Daejeon 305-764 (Korea, Republic of); Woo Byun, Myung [Radiation Food Science and Biotechnology Team, Korea Atomic Energy Research Institute, Jeongeup 580-185 (Korea, Republic of); Jeun An, Bong [Department of Cosmeceutical Science, Daegu Haany University, Kyungsan 712-715 (Korea, Republic of)], E-mail: anbj@dhu.ac.kr

    2007-11-15

    Sopoongsan is an oriental medicinal prescription including 12 medicinal herbs. Sopoongsan is known to have anti-inflammatory, anti-microbial, anti-allergic, and anti-cancer effects on human skin. To use Sopoongsan extract for functional cosmetic composition, its dark color should be brighter for seeking consumer demand, clear products, without any adverse change in its function. Irradiation with doses 0, 5, 10, and 20 kGy was applied to improve color of ethanol- or water-extracted Sopoongsan and also superoxide dismutase (SOD), xanthine oxidase (XO), melanoma cell growth inhibition, and anti-microbial activity was investigated. Generally, ethanol extract was better than water extract in function and irradiation up to 20 kGy did not change any functional effect. Especially, the inhibition of melanin deposition on skin measured by inhibition of B16F10 (melanoma) cell growth was as high as arbutin, commercially available product, when the ethanol-extracted Sopoongsan was irradiated for 20 kGy. Results showed that when irradiation technology is used, the limitation of addition amount of natural materials for food or cosmetic composition caused by color problem can be decreased significantly with time saving and cost benefit compared to conventional color removal process. Therefore, irradiation would be one of the good methods to pose an additional value for related industry.

  2. Verification of biological activity of irradiated Sopoongsan, an oriental medicinal prescription, for industrial application of functional cosmetic material

    Science.gov (United States)

    Lee, Jin-Young; Park, Tae-Soon; Ho Son, Jun; Jo, Cheorun; Woo Byun, Myung; Jeun An, Bong

    2007-11-01

    Sopoongsan is an oriental medicinal prescription including 12 medicinal herbs. Sopoongsan is known to have anti-inflammatory, anti-microbial, anti-allergic, and anti-cancer effects on human skin. To use Sopoongsan extract for functional cosmetic composition, its dark color should be brighter for seeking consumer demand, clear products, without any adverse change in its function. Irradiation with doses 0, 5, 10, and 20 kGy was applied to improve color of ethanol- or water-extracted Sopoongsan and also superoxide dismutase (SOD), xanthine oxidase (XO), melanoma cell growth inhibition, and anti-microbial activity was investigated. Generally, ethanol extract was better than water extract in function and irradiation up to 20 kGy did not change any functional effect. Especially, the inhibition of melanin deposition on skin measured by inhibition of B16F10 (melanoma) cell growth was as high as arbutin, commercially available product, when the ethanol-extracted Sopoongsan was irradiated for 20 kGy. Results showed that when irradiation technology is used, the limitation of addition amount of natural materials for food or cosmetic composition caused by color problem can be decreased significantly with time saving and cost benefit compared to conventional color removal process. Therefore, irradiation would be one of the good methods to pose an additional value for related industry.

  3. The mechanical power output of the pectoralis muscle of cockatiel (Nymphicus hollandicus): the in vivo muscle length trajectory and activity patterns and their implications for power modulation.

    Science.gov (United States)

    Morris, Charlotte R; Askew, Graham N

    2010-08-15

    In order to meet the varying demands of flight, pectoralis muscle power output must be modulated. In birds with pectoralis muscles with a homogeneous fibre type composition, power output can be modulated at the level of the motor unit (via changes in muscle length trajectory and the pattern of activation), at the level of the muscle (via changes in the number of motor units recruited), and at the level of the whole animal (through the use of intermittent flight). Pectoralis muscle length trajectory and activity patterns were measured in vivo in the cockatiel (Nymphicus hollandicus) at a range of flight speeds (0-16 m s(-1)) using sonomicrometry and electromyography. The work loop technique was used to measure the mechanical power output of a bundle of fascicles isolated from the pectoralis muscle during simulated in vivo length change and activity patterns. The mechanical power-speed relationship was U-shaped, with a 2.97-fold variation in power output (40-120 W kg(-1)). In this species, modulation of neuromuscular activation is the primary strategy utilised to modulate pectoralis muscle power output. Maximum in vivo power output was 22% of the maximum isotonic power output (533 W kg(-1)) and was generated at a lower relative shortening velocity (0.28 V(max)) than the maximum power output during isotonic contractions (0.34 V(max)). It seems probable that the large pectoralis muscle strains result in a shift in the optimal relative shortening velocity in comparison with the optimum during isotonic contractions as a result of length-force effects.

  4. Active site modification of the β-ketoacyl-ACP synthase FabF3 of Streptomyces coelicolor affects the fatty acid chain length of the CDA lipopeptides.

    Science.gov (United States)

    Lewis, Richard A; Nunns, Laura; Thirlway, Jenny; Carroll, Kathleen; Smith, Colin P; Micklefield, Jason

    2011-02-14

    Using site directed mutagenesis we altered an active site residue (Phe107) of the enzyme encoded by fabF3 (SCO3248) in the Streptomyces coelicolor gene cluster required for biosynthesis of the calcium dependent antibiotics (CDAs), successfully generating two novel CDA derivatives comprising truncated (C4) lipid side chains and confirming that fabF3 encodes a KAS-II homologue that is involved in determining CDA fatty acid chain length.

  5. Investigation of double bond conversion, mechanical properties, and antibacterial activity of dental resins with different alkyl chain length quaternary ammonium methacrylate monomers (QAM).

    Science.gov (United States)

    He, Jingwei; Söderling, Eva; Vallittu, Pekka K; Lassila, Lippo V J

    2013-01-01

    In order to endow dental resin with antibacterial activity, a series of antibacterial quaternary ammonium methacrylate monomers (QAM) with different substituted alkyl chain length (from 10 to 18) were incorporated into commonly used 2,2-bis[4-(2'-hydroxy-3'-methacryloyloxy-propoxy)-phenyl]propane (Bis-GMA)/triethyleneglycol dimethacrylate (TEGDMA) (50 wt/50 wt) dental resin as immobilized antibacterial agents. Double bond conversion (DC), flexural strength (FS) and modulus (FM), and young and mature biofilms inhibition effectiveness of prepared dental resins were studied and Bis-GMA/TEGDMA without QAM was used as reference. Results showed that there was no significant difference on DC, FS, and FM between copolymer with and without 5 wt% QAM. Substituted alkyl chain length of QAM had no influence on DC, FS, and FM of copolymer, but had influence on antibacterial activity of copolymer. Antibacterial activity of copolymer increased with increasing of substituted alkyl chain length of QAM, and the sequence followed as 5%C10 < 5%C11 ≈ 5%C12 < 5%C16 ≈ 5%C18. Copolymers containing C18 and C16 had the best inhibition effectiveness on both young biofilm and mature biofilm, copolymers containing C12 and C11 only had inhibition effectiveness on young biofilm and copolymer containing C10 had none inhibition effectiveness on neither young biofilm nor mature biofilm.

  6. Relativistic Length Agony Continued

    Science.gov (United States)

    Redzic, D. V.

    2014-06-01

    We made an attempt to remedy recent confusing treatments of some basic relativistic concepts and results. Following the argument presented in an earlier paper (Redzic 2008b), we discussed the misconceptions that are recurrent points in the literature devoted to teaching relativity such as: there is no change in the object in Special Relativity, illusory character of relativistic length contraction, stresses and strains induced by Lorentz contraction, and related issues. We gave several examples of the traps of everyday language that lurk in Special Relativity. To remove a possible conceptual and terminological muddle, we made a distinction between the relativistic length reduction and relativistic FitzGerald-Lorentz contraction, corresponding to a passive and an active aspect of length contraction, respectively; we pointed out that both aspects have fundamental dynamical contents. As an illustration of our considerations, we discussed briefly the Dewan-Beran-Bell spaceship paradox and the 'pole in a barn' paradox.

  7. Writer identification and verification

    NARCIS (Netherlands)

    Schomaker, Lambert; Ratha, N; Govindaraju, V

    2008-01-01

    Writer identification and verification have gained increased interest recently, especially in the fields of forensic document examination and biometrics. Writer identification assigns a handwriting to one writer out of a set of writers. It determines whether or not a given handwritten text has in

  8. Integrated Java Bytecode Verification

    DEFF Research Database (Denmark)

    Gal, Andreas; Probst, Christian; Franz, Michael

    2005-01-01

    Existing Java verifiers perform an iterative data-flow analysis to discover the unambiguous type of values stored on the stack or in registers. Our novel verification algorithm uses abstract interpretation to obtain definition/use information for each register and stack location in the program...

  9. Active assistive forced exercise provides long-term improvement to gait velocity and stride length in patients bilaterally affected by Parkinson's disease.

    Science.gov (United States)

    Stuckenschneider, T; Helmich, I; Raabe-Oetker, A; Froböse, I; Feodoroff, B

    2015-10-01

    Forced exercise training presents a valid method of improving symptoms of Parkinson's disease such as rigor, dyskinesia and gait dysfunctions. Brain imaging data suggest that use of active assistive forced exercise could improve Parkinsonian symptoms more effectively than passive assistive forced exercise. However, the long-term effects of active versus passive assistive forced exercise on the symptoms of Parkinson's disease are unknown. Here, 24 patients showing bilateral effects of Parkinson's disease underwent a 12 week intervention of either passive or active assistive forced exercise. We analyzed tremor scores, gait patterns, and scores on the Unified Parkinson's Disease Rating Scale-III from three timepoints--before beginning the intervention, upon completion of the intervention, and twelve weeks after completion of the intervention. Participation in both passive and active assistive forced exercise increased gait velocity (0.5 km/h), swing phase (2%), monopedal stance phase (2%), elongated stride length (11 cm) and decreased double stance phase (4%). However, with participation in active assistive forced exercise, postural and kinetic tremor were also reduced and gait velocity and stride length were increased long-term. Given these findings, we conclude that future treatment for patients bilaterally affected by Parkinson's disease should carefully consider the type of assistive forced exercise intervention to be used. Copyright © 2015 Elsevier B.V. All rights reserved.

  10. DFT Study of the Oxygen Reduction Reaction Activity on Fe-N₄-Patched Carbon Nanotubes: The Influence of the Diameter and Length.

    Science.gov (United States)

    Chen, Xin; Hu, Rui; Bai, Fan

    2017-05-18

    The influences of diameter and length of the Fe-N₄-patched carbon nanotubes (Fe-N₄/CNTs) on oxygen reduction reaction (ORR) activity were investigated by density functional theory method using the BLYP/DZP basis set. The results indicate that the stability of the Fe-N₄ catalytic site in Fe-N₄/CNTs will be enhanced with a larger tube diameter, but reduced with shorter tube length. A tube with too small a diameter makes a Fe-N₄ site unstable in acid medium since Fe-N and C-N bonds must be significantly bent at smaller diameters due to hoop strain. The adsorption energy of the ORR intermediates, especially of the OH group, becomes weaker with the increase of the tube diameter. The OH adsorption energy of Fe-N₄/CNT with the largest tube diameter is close to that on Pt(111) surface, indicating that its catalytic property is similar to Pt. Electronic structure analysis shows that the OH adsorption energy is mainly controlled by the energy levels of Fe 3d orbital. The calculation results uncover that Fe-N₄/CNTs with larger tube diameters and shorter lengths will exhibit better ORR activity and stability.

  11. Influence of posterior dental arch length on brain activity during chewing in patients with mandibular distal extension removable partial dentures.

    Science.gov (United States)

    Shoi, K; Fueki, K; Usui, N; Taira, M; Wakabayashi, N

    2014-07-01

    It is well known that shortened dental arch decreases masticatory function. However, its potential to change brain activity during mastication is unknown. The present study investigates the effect of a shortened posterior dental arch with mandibular removable partial dentures (RPDs) on brain activity during gum chewing. Eleven subjects with missing mandibular molars (mean age, 66.1 years) on both sides received experimental RPDs with interchangeable artificial molars in a crossover trial design. Brain activity during gum chewing with RPDs containing (full dental arch) and lacking artificial molars (shortened dental arch) was measured using functional magnetic resonance imaging. Additionally, masticatory function was evaluated for each dental arch type. Food comminuting and mixing ability and the perceived chewing ability were significantly lower in subjects with a shortened dental arch than those with a full dental arch (P < 0.05). Brain activation during gum chewing with the full dental arch occurred in the middle frontal gyrus, primary sensorimotor cortex extending to the pre-central gyrus, supplementary motor area, putamen, insula and cerebellum. However, middle frontal gyrus activation was not observed during gum chewing with the shortened dental arch. These results suggest that shortened dental arch affects human brain activity in the middle frontal gyrus during gum chewing, and the decreased middle frontal gyrus activation may be associated with decreased masticatory function. © 2014 John Wiley & Sons Ltd.

  12. Measurement of muscle length-related electromyography activity of the hip flexor muscles to determine individual muscle contributions to the hip flexion torque.

    Science.gov (United States)

    Jiroumaru, Takumi; Kurihara, Toshiyuki; Isaka, Tadao

    2014-01-01

    This study aimed to investigate muscle length-related electromyography (EMG) of the iliopsoas (IL) and other hip flexor muscles to determine individual muscle contributions to the hip flexion torque. Ten healthy sedentary young men participated in the EMG experiment. A subgroup of six subjects underwent a magnetic resonance imaging (MRI) measurement to confirm the region of the skin over the IL. Surface EMG signals were sampled from the IL, rectus femoris (RF), sartorius (SA), and tensor fasciae latae (TFL) using an active electrode. The subjects performed maximum voluntary isometric hip flexion with the right hip joint set at -10°, 0°, 30°, and 60°. The root mean square (RMS) value for the TFL at 30° (0.81 ± 0.19, p muscle length changes were significantly correlated in the IL (r =0.39, p muscles.

  13. DNA methylation changes in response to active smoking exposure are associated with leukocyte telomere length among older adults.

    Science.gov (United States)

    Gao, Xu; Mons, Ute; Zhang, Yan; Breitling, Lutz Philipp; Brenner, Hermann

    2016-12-01

    Telomere length (TL) is associated with an increased risk of aging-related diseases. As a preventable environmental hazard of morbidity and mortality, smoking has been reported to promote TL attrition by producing a variety of oxidants and free radicals. Since DNA methylation has been demonstrated to play an important role in the pathways of smoking and smoking-induced diseases, this study aimed to address whether the smoking-associated DNA methylation changes could be associated with accelerated TL shortening. We obtained DNA methylation profiles in whole blood samples by Illumina Infinium Human Methylation 450 Beadchip array in two independent subsamples of the ESTHER study and measured their relative TL by quantitative PCR. Terminal Restriction Fragment analysis was additionally performed in a subsample to obtain absolute TL in base pairs. TL measurements across panels were standardized by z-transformation. After correction for multiple testing, we successfully confirmed that seven out of 151 smoking-related CpG sites were associated with TL (FDR smoking index based on the seven loci showed monotonic associations with TL, cumulative smoking exposure and time after smoking cessation. In conclusion, our study supports suggestions that epigenetic alterations could play a role in smoking-associated disproportionate aging as reflected by TL. Further research is required to examine whether the identified epigenetic signatures of smoking can be of value in clinical practice to assess individual aging across the lifespan.

  14. Solar cycle length hypothesis appears to support the IPCC on global warming

    DEFF Research Database (Denmark)

    Laut, Peter; Gundermann, Jesper

    1999-01-01

    lengths with the "corrected" temperature anomalies is substantially better than with the historical anomalies. Therefore our findings support a total reversal of the common assumption that a verification of the solar hypothesis would challenge the IPCC assessment of man-made global warming.......Since the discovery of a striking correlation between 1-2-2-2-1 filtered solar cycle lengths and the 11-year running average of Northern Hemisphere land air temperatures there have been widespread speculations as to whether these findings would rule out any significant contributions to global...... warming from the enhanced concentrations of greenhouse gases. The "solar hypothesis" claims that solar activity causes a significant component of the global mean temperature to vary in phase opposite to the filtered solar cycle lengths. In an earlier paper we have demonstrated that for data covering...

  15. The Presence of Telomere Fusion in Sporadic Colon Cancer Independently of Disease Stage, TP53/KRAS Mutation Status, Mean Telomere Length, and Telomerase Activity

    Directory of Open Access Journals (Sweden)

    Hiromi Tanaka

    2014-10-01

    Full Text Available Defects in telomere maintenance can result in telomere fusions that likely play a causative role in carcinogenesis by promoting genomic instability. However, this proposition remains to be fully understood in human colon carcinogenesis. In the present study, the temporal sequence of telomere dysfunction dynamics was delineated by analyzing telomere fusion, telomere length, telomerase activity, hotspot mutations in KRAS or BRAF, and TP53 of tissue samples obtained from 18 colon cancer patients. Our results revealed that both the deficiency of p53 and the shortening of mean telomere length were not necessary for producing telomere fusions in colon tissue. In five cases, telomere fusion was observed even in tissue adjacent to cancerous lesions, suggesting that genomic instability is initiated in pathologically non-cancerous lesions. The extent of mean telomere attrition increased with lymph node invasiveness of tumors, implying that mean telomere shortening correlates with colon cancer progression. Telomerase activity was relatively higher in most cancer tissues containing mutation(s in KRAS or BRAF and/or TP53 compared to those without these hotspot mutations, suggesting that telomerase could become fully active at the late stage of colon cancer development. Interestingly, the majority of telomere fusion junctions in colon cancer appeared to be a chromatid-type containing chromosome 7q or 12q. In sum, this meticulous correlative study not only highlights the concept that telomere fusion is present in the early stages of cancer regardless of TP53/KRAS mutation status, mean telomere length, and telomerase activity, but also provides additional insights targeting key telomere fusion junctions which may have significant implications for colon cancer diagnoses.

  16. The effects of speed on the in vivo activity and length of a limb muscle during the locomotion of the iguanian lizard Dipsosaurus dorsalis.

    Science.gov (United States)

    Nelson, F E; Jayne, B C

    2001-10-01

    The caudofemoralis muscle is the largest muscle that inserts onto the hindlimb of most ectothermic tetrapods, and previous studies hypothesize that it causes several movements that characterize the locomotion of vertebrates with a sprawling limb posture. Predicting caudofemoralis function is complicated because the muscle spans multiple joints with movements that vary with speed. Furthermore, depending on when any muscle is active relative to its change in length, its function can change from actively generating mechanical work to absorbing externally applied forces. We used synchronized electromyography, sonomicrometry and three-dimensional kinematics to determine in vivo caudofemoralis function in the desert iguana Dipsosaurus dorsalis for a wide range of speeds of locomotion from a walk to nearly maximal sprinting (50-350 cm s(-1)). Strain of the caudofemoralis increased with increasing tail elevation and long-axis rotation and protraction of the femur. However, knee extension only increased caudofemoralis strain when the femur was protracted. The maximum and minimum length of the caudofemoralis muscle and its average shortening velocity increased from the slowest speed up to the walk-run transition, but changed little with further increases in speed. The times of muscle shortening and lengthening were often not equal at higher locomotor speeds. Some (20-25 ms) activity occurred during lengthening of the caudofemoralis muscle before footfall. However, most caudofemoralis activity was consistent with performing positive mechanical work to flex the knee shortly after foot contact and to retract and rotate the femur throughout the propulsive phase.

  17. Locomotor changes in length and EMG activity of feline medial gastrocnemius muscle following paralysis of two synergists

    NARCIS (Netherlands)

    Maas, H.; Gregor, R.J.; Hodson-Tole, E.F.; Farrell, B.J.; English, A.W.; Prilutsky, B.I.

    2010-01-01

    The mechanism of the compensatory increase in electromyographic activity (EMG) of a cat ankle extensor during walking shortly after paralysis of its synergists is not fully understood. It is possible that due to greater ankle Xexion in stance in this situation, muscle spindles are stretched to a

  18. Distorted Fingerprint Verification System

    Directory of Open Access Journals (Sweden)

    Divya KARTHIKAESHWARAN

    2011-01-01

    Full Text Available Fingerprint verification is one of the most reliable personal identification methods. Fingerprint matching is affected by non-linear distortion introduced in fingerprint impression during the image acquisition process. This non-linear deformation changes both the position and orientation of minutiae. The proposed system operates in three stages: alignment based fingerprint matching, fuzzy clustering and classifier framework. First, an enhanced input fingerprint image has been aligned with the template fingerprint image and matching score is computed. To improve the performance of the system, a fuzzy clustering based on distance and density has been used to cluster the feature set obtained from the fingerprint matcher. Finally a classifier framework has been developed and found that cost sensitive classifier produces better results. The system has been evaluated on fingerprint database and the experimental result shows that system produces a verification rate of 96%. This system plays an important role in forensic and civilian applications.

  19. GRAVITY Science Verification

    Science.gov (United States)

    Mérand, A.; Berger, J.-P.; de Wit, W.-J.; Eisenhauer, F.; Haubois, X.; Paumard, T.; Schoeller, M.; Wittkowski, M.; Woillez, J.; Wolff, B.

    2017-12-01

    In the time between successfully commissioning an instrument and before offering it in the Call for Proposals for the first time, ESO gives the community at large an opportunity to apply for short Science Verification (SV) programmes. In 2016, ESO offered SV time for the second-generation Very Large Telescope Interferometer instrument GRAVITY. In this article we describe the selection process, outline the range of science cases covered by the approved SV programmes, and highlight some of the early scientific results.

  20. EFFECT OF RESTRICTED HIP FLEXOR MUSCLE LENGTH ON HIP EXTENSOR MUSCLE ACTIVITY AND LOWER EXTREMITY BIOMECHANICS IN COLLEGE-AGED FEMALE SOCCER PLAYERS.

    Science.gov (United States)

    Mills, Matthew; Frank, Barnett; Goto, Shiho; Blackburn, Troy; Cates, Samantha; Clark, Michael; Aguilar, Alain; Fava, Nicole; Padua, Darin

    2015-12-01

    Hip flexor tightness is theorized to alter antagonist muscle function through reciprocal inhibition and synergistic dominance mechanisms. Synergistic dominance may result in altered movement patterns and increased risk of lower extremity injury. To compare hip extensor muscle activation, internal hip and knee extension moments during double-leg squatting, and gluteus maximus strength in those with and without clinically restricted hip flexor muscle length. Causal-comparative cross-sectional laboratory study. Using a modified Thomas Test, female soccer athletes were assigned to a restricted (>0 ° of sagittal plane hip motion above the horizontal; n=20, age=19.9 ± 1 years, ht=167.1 ± 6.4 cm, mass=64.7 ± 8.2kg) or normal (>15 ° of sagittal plane hip motion below horizontal; n=20, age=19.4 ± 1 years, ht=167.2 ± 5.5 cm, mass=61.2 ± 8.6 kg) hip flexor muscle length group. Surface electromyographic (sEMG) activity of the gluteus maximus and biceps femoris, and net internal hip and knee extension moments were measured between groups during a double-leg squat. Isometric gluteus maximus strength was assessed using handheld dynamometry. Individuals with restricted hip flexor muscle length demonstrated less gluteus maximus activation (p=0.008) and a lower gluteus maximus : biceps femoris co-activation ratio (p=0.004). There were no significant differences (p>0.05) in hip or knee extension moments, isometric gluteus maximus strength, or biceps femoris activation between groups. Female soccer athletes with hip flexor muscle tightness exhibit less gluteus maximus activation and lower gluteus maximus : biceps femoris co-activation while producing similar net hip and knee extension moments. Thus, individuals with hip flexor muscle tightness appear to utilize different neuromuscular strategies to control lower extremity motion. 3.

  1. Telomerase-Associated Protein TEP1 Is Not Essential for Telomerase Activity or Telomere Length Maintenance In Vivo

    OpenAIRE

    Liu, Yie; Snow, Bryan E.; Hande, M. Prakash; Baerlocher, Gabriela; Kickhoefer, Valerie A.; Yeung, David; Wakeham, Andrew; Itie, Annick; Siderovski, David P.; Lansdorp, Peter M.; Robinson, Murray O.; Harrington, Lea

    2000-01-01

    TEP1 is a mammalian telomerase-associated protein with similarity to the Tetrahymena telomerase protein p80. Like p80, TEP1 is associated with telomerase activity and the telomerase reverse transcriptase, and it specifically interacts with the telomerase RNA. To determine the role of mTep1 in telomerase function in vivo, we generated mouse embryonic stem (ES) cells and mice lacking mTep1. The mTep1-deficient (mTep1−/−) mice were viable and were bred for seven successive generations with no ob...

  2. Influenza activity in Europe during eight seasons (1999–2007: an evaluation of the indicators used to measure activity and an assessment of the timing, length and course of peak activity (spread across Europe

    Directory of Open Access Journals (Sweden)

    Meijer Adam

    2007-11-01

    Full Text Available Abstract Background The European Influenza Surveillance Scheme (EISS has collected clinical and virological data on influenza since 1996 in an increasing number of countries. The EISS dataset was used to characterise important epidemiological features of influenza activity in Europe during eight winters (1999–2007. The following questions were addressed: 1 are the sentinel clinical reports a good measure of influenza activity? 2 how long is a typical influenza season in Europe? 3 is there a west-east and/or south-north course of peak activity ('spread' of influenza in Europe? Methods Influenza activity was measured by collecting data from sentinel general practitioners (GPs and reports by national reference laboratories. The sentinel reports were first evaluated by comparing them to the laboratory reports and were then used to assess the timing and spread of influenza activity across Europe during eight seasons. Results We found a good match between the clinical sentinel data and laboratory reports of influenza collected by sentinel physicians (overall match of 72% for +/- 1 week difference. We also found a moderate to good match between the clinical sentinel data and laboratory reports of influenza from non-sentinel sources (overall match of 60% for +/- 1 week. There were no statistically significant differences between countries using ILI (influenza-like illness or ARI (acute respiratory disease as case definition. When looking at the peak-weeks of clinical activity, the average length of an influenza season in Europe was 15.6 weeks (median 15 weeks; range 12–19 weeks. Plotting the peak weeks of clinical influenza activity reported by sentinel GPs against the longitude or latitude of each country indicated that there was a west-east spread of peak activity (spread of influenza across Europe in four winters (2001–2002, 2002–2003, 2003–2004 and 2004–2005 and a south-north spread in three winters (2001–2002, 2004–2005 and 2006

  3. Relationship between Initial Telomere Length, Initial Telomerase Activity, Age, and Replicative Capacity of Nucleus Pulposus Chondrocytes in Human Intervertebral Discs: What Is a Predictor of Replicative Potential?

    Science.gov (United States)

    Lee, Jun-Seok; Jeong, Seo-Won; Cho, Sung-Wook; Juhn, Joon-Pyo; Kim, Ki-Won

    2015-01-01

    There is evidence that telomere length (TL), telomerase activity (TA), and age are related to the replicative potential of human nucleus pulposus chondrocytes (NPCs). However, it has not yet been established if any of these factors can serve as predictors of the replicative potential of NPCs. To establish predictors of the replicative potential of NPCs, we evaluated potential relationships between replicative capacity of NPCs, initial TL (telomere length at the first passage), initial TA (telomerase activity at the first passage), and age. Nucleus pulposus specimens were obtained from 14 patients of various ages undergoing discectomy. NPCs were serially cultivated until the end of their replicative lifespans. Relationships among cumulative population doubling level (PDL), initial TL, initial TA, and age were analyzed. Initial TA was negatively correlated with age (r = -0.674, P = 0.008). However, no correlation between initial TL and age was observed. Cumulative PDL was also negatively correlated with age (r = -0.585, P = 0.028). Although the cumulative PDL appeared to increase with initial TL or initial TA, this trend was not statistically significant. In conclusion, age is the sole predictor of the replicative potential of human NPCs, and replicative potential decreases with age. Initial TL and initial TA are not predictors of replicative potential, and can serve only as reference values.

  4. Formal Verification of UML Profil

    DEFF Research Database (Denmark)

    Bhutto, Arifa; Hussain, Dil Muhammad Akbar

    2011-01-01

    The Unified Modeling Language (UML) is based on the Model Driven Development (MDD) approach which capturing the system functionality using the platform-independent model (PMI) and appropriate domain-specific languages. In UML base system notations, structural view is model by the class, components...... and object diagrams and behavioral view model by the activity, use case, state, and sequence diagram. However, UML does not provide the formal syntax, therefore its semantics is not formally definable, so for assure of correctness, we need to incorporate semantic reasoning through verification, specification......, refinement, and incorporate into the development process. Our motivation of research is to make an easy structural view and suggest formal technique/ method which can be best applied or used for the UML based development system. We investigate the tools and methods, which broadly used for the formal...

  5. Scalable Techniques for Formal Verification

    CERN Document Server

    Ray, Sandip

    2010-01-01

    This book presents state-of-the-art approaches to formal verification techniques to seamlessly integrate different formal verification methods within a single logical foundation. It should benefit researchers and practitioners looking to get a broad overview of the spectrum of formal verification techniques, as well as approaches to combining such techniques within a single framework. Coverage includes a range of case studies showing how such combination is fruitful in developing a scalable verification methodology for industrial designs. This book outlines both theoretical and practical issue

  6. Survey on Offline Finger Print Verification System

    NARCIS (Netherlands)

    Suman, R.; Kaur, R.

    2012-01-01

    The fingerprint verification, means where "verification" implies a user matching a fingerprint against a single fingerprint associated with the identity that the user claims. Biometrics can be classified into two types Behavioral (signature verification, keystroke dynamics, etc.) And Physiological

  7. Relativistic length agony continued

    Directory of Open Access Journals (Sweden)

    Redžić D.V.

    2014-01-01

    Full Text Available We made an attempt to remedy recent confusing treatments of some basic relativistic concepts and results. Following the argument presented in an earlier paper (Redžić 2008b, we discussed the misconceptions that are recurrent points in the literature devoted to teaching relativity such as: there is no change in the object in Special Relativity, illusory character of relativistic length contraction, stresses and strains induced by Lorentz contraction, and related issues. We gave several examples of the traps of everyday language that lurk in Special Relativity. To remove a possible conceptual and terminological muddle, we made a distinction between the relativistic length reduction and relativistic FitzGerald-Lorentz contraction, corresponding to a passive and an active aspect of length contraction, respectively; we pointed out that both aspects have fundamental dynamical contents. As an illustration of our considerations, we discussed briefly the Dewan-Beran-Bell spaceship paradox and the ‘pole in a barn’ paradox. [Projekat Ministarstva nauke Republike Srbije, br. 171028

  8. High-level verification

    CERN Document Server

    Lerner, Sorin; Kundu, Sudipta

    2011-01-01

    Given the growing size and heterogeneity of Systems on Chip (SOC), the design process from initial specification to chip fabrication has become increasingly complex. This growing complexity provides incentive for designers to use high-level languages such as C, SystemC, and SystemVerilog for system-level design. While a major goal of these high-level languages is to enable verification at a higher level of abstraction, allowing early exploration of system-level designs, the focus so far for validation purposes has been on traditional testing techniques such as random testing and scenario-based

  9. Keeping disease at arm's length

    DEFF Research Database (Denmark)

    Lassen, Aske Juul

    2015-01-01

    Many older people live with a range of chronic diseases. However, these diseases do not necessarily impede an active lifestyle. In this article the author analyses the relation between the active ageing discourse and the way older people at two Danish activity centres handle disease. How does...... active ageing change everyday life with chronic disease, and how do older people combine an active life with a range of chronic diseases? The participants in the study use activities to keep their diseases at arm’s length, and this distancing of disease at the same time enables them to engage in social...... and physical activities at the activity centre. In this way, keeping disease at arm’s length is analysed as an ambiguous health strategy. The article shows the importance of looking into how active ageing is practised, as active ageing seems to work well in the everyday life of the older people by not giving...

  10. TFE Verification Program

    Energy Technology Data Exchange (ETDEWEB)

    1993-05-01

    The objective of the semiannual progress report is to summarize the technical results obtained during the latest reporting period. The information presented herein will include evaluated test data, design evaluations, the results of analyses and the significance of results. The program objective is to demonstrate the technology readiness of a TFE (thermionic fuel element) suitable for use as the basic element in a thermionic reactor with electric power output in the 0.5 to 5.0 MW(e) range, and a full-power life of 7 years. The TFE Verification Program builds directly on the technology and data base developed in the 1960s and early 1970s in an AEC/NASA program, and in the SP-100 program conducted in 1983, 1984 and 1985. In the SP-100 program, the attractive features of thermionic power conversion technology were recognized but concern was expressed over the lack of fast reactor irradiation data. The TFE Verification Program addresses this concern.

  11. Using SysML for verification and validation planning on the Large Synoptic Survey Telescope (LSST)

    Science.gov (United States)

    Selvy, Brian M.; Claver, Charles; Angeli, George

    2014-08-01

    This paper provides an overview of the tool, language, and methodology used for Verification and Validation Planning on the Large Synoptic Survey Telescope (LSST) Project. LSST has implemented a Model Based Systems Engineering (MBSE) approach as a means of defining all systems engineering planning and definition activities that have historically been captured in paper documents. Specifically, LSST has adopted the Systems Modeling Language (SysML) standard and is utilizing a software tool called Enterprise Architect, developed by Sparx Systems. Much of the historical use of SysML has focused on the early phases of the project life cycle. Our approach is to extend the advantages of MBSE into later stages of the construction project. This paper details the methodology employed to use the tool to document the verification planning phases, including the extension of the language to accommodate the project's needs. The process includes defining the Verification Plan for each requirement, which in turn consists of a Verification Requirement, Success Criteria, Verification Method(s), Verification Level, and Verification Owner. Each Verification Method for each Requirement is defined as a Verification Activity and mapped into Verification Events, which are collections of activities that can be executed concurrently in an efficient and complementary way. Verification Event dependency and sequences are modeled using Activity Diagrams. The methodology employed also ties in to the Project Management Control System (PMCS), which utilizes Primavera P6 software, mapping each Verification Activity as a step in a planned activity. This approach leads to full traceability from initial Requirement to scheduled, costed, and resource loaded PMCS task-based activities, ensuring all requirements will be verified.

  12. Mesenchymal stem cells with high telomerase expression do not actively restore their chromosome arm specific telomere length pattern after exposure to ionizing radiation

    DEFF Research Database (Denmark)

    Graakjaer, Jesper; Christensen, Rikke; Kolvraa, Steen

    2007-01-01

    investigate the existence and maintenance of the telomere length pattern in stem cells. For this aim we studied telomere length in primary human mesenchymal stem cells (hMSC) and their telomerase-immortalised counterpart (hMSC-telo1) during extended proliferation as well as after irradiation. Telomere lengths...

  13. Compositional Verification of Multi-Station Interlocking Systems

    DEFF Research Database (Denmark)

    Macedo, Hugo Daniel dos Santos; Fantechi, Alessandro; Haxthausen, Anne Elisabeth

    2016-01-01

    Because interlocking systems are highly safety-critical complex systems, their automated safety verification is an active research topic investigated by several groups, employing verification techniques to produce important cost and time savings in their certification. However, such systems also...... pose a big challenge to current verification methodologies, due to the explosion of state space size as soon as large, if not medium sized, multi-station systems have to be controlled. For these reasons, verification techniques that exploit locality principles related to the topological layout...... method to verify the size of rather large networks, we propose a compositional approach that is particularly suitable to address multi-station interlocking systems which control a whole line composed of stations linked by mainline tracks. Indeed, it turns out that for such networks, and for the adopted...

  14. Shift Verification and Validation

    Energy Technology Data Exchange (ETDEWEB)

    Pandya, Tara M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Evans, Thomas M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Davidson, Gregory G [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Johnson, Seth R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Godfrey, Andrew T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-09-07

    This documentation outlines the verification and validation of Shift for the Consortium for Advanced Simulation of Light Water Reactors (CASL). Five main types of problems were used for validation: small criticality benchmark problems; full-core reactor benchmarks for light water reactors; fixed-source coupled neutron-photon dosimetry benchmarks; depletion/burnup benchmarks; and full-core reactor performance benchmarks. We compared Shift results to measured data and other simulated Monte Carlo radiation transport code results, and found very good agreement in a variety of comparison measures. These include prediction of critical eigenvalue, radial and axial pin power distributions, rod worth, leakage spectra, and nuclide inventories over a burn cycle. Based on this validation of Shift, we are confident in Shift to provide reference results for CASL benchmarking.

  15. Overview of Code Verification

    Science.gov (United States)

    1983-01-01

    The verified code for the SIFT Executive is not the code that executes on the SIFT system as delivered. The running versions of the SIFT Executive contain optimizations and special code relating to the messy interface to the hardware broadcast interface and to packing of data to conserve space in the store of the BDX930 processors. The running code was in fact developed prior to and without consideration of any mechanical verification. This was regarded as necessary experimentation with the SIFT hardware and special purpose Pascal compiler. The Pascal code sections cover: the selection of a schedule from the global executive broadcast, scheduling, dispatching, three way voting, and error reporting actions of the SIFT Executive. Not included in these sections of Pascal code are: the global executive, five way voting, clock synchronization, interactive consistency, low level broadcasting, and program loading, initialization, and schedule construction.

  16. Online fingerprint verification.

    Science.gov (United States)

    Upendra, K; Singh, S; Kumar, V; Verma, H K

    2007-01-01

    As organizations search for more secure authentication methods for user access, e-commerce, and other security applications, biometrics is gaining increasing attention. With an increasing emphasis on the emerging automatic personal identification applications, fingerprint based identification is becoming more popular. The most widely used fingerprint representation is the minutiae based representation. The main drawback with this representation is that it does not utilize a significant component of the rich discriminatory information available in the fingerprints. Local ridge structures cannot be completely characterized by minutiae. Also, it is difficult quickly to match two fingerprint images containing different number of unregistered minutiae points. In this study filter bank based representation, which eliminates these weakness, is implemented and the overall performance of the developed system is tested. The results have shown that this system can be used effectively for secure online verification applications.

  17. Parking Space Verification

    DEFF Research Database (Denmark)

    Høg Peter Jensen, Troels; Thomsen Schmidt, Helge; Dyremose Bodin, Niels

    2018-01-01

    With the number of privately owned cars increasing, the issue of locating an available parking space becomes apparant. This paper deals with the verification of vacant parking spaces, by using a vision based system looking over parking areas. In particular the paper proposes a binary classifier...... system, based on a Convolutional Neural Network, that is capable of determining if a parking space is occupied or not. A benchmark database consisting of images captured from different parking areas, under different weather and illumination conditions, has been used to train and test the system....... The system shows promising performance on the database with an accuracy of 99.71% overall and is robust to the variations in parking areas and weather conditions....

  18. Reconfigurable system design and verification

    CERN Document Server

    Hsiung, Pao-Ann; Huang, Chun-Hsian

    2009-01-01

    Reconfigurable systems have pervaded nearly all fields of computation and will continue to do so for the foreseeable future. Reconfigurable System Design and Verification provides a compendium of design and verification techniques for reconfigurable systems, allowing you to quickly search for a technique and determine if it is appropriate to the task at hand. It bridges the gap between the need for reconfigurable computing education and the burgeoning development of numerous different techniques in the design and verification of reconfigurable systems in various application domains. The text e

  19. Formal Verification of Circuits and Systems

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    methods in the verification task. Today formal verification is finding increasing acceptance ... approaches that are major research issues in formal verification research today. There are four articles in this issue, which show up the different flavours in the approach to formal methods in verification. The first paper by Supratik ...

  20. Verification methodology manual for SystemVerilog

    CERN Document Server

    Bergeron, Janick; Hunter, Alan

    2006-01-01

    SystemVerilog is a unified language that serves both design and verification engineers by including RTL design constructs, assertions and a rich set of verification constructs. This book is based upon best verification practices by ARM, Synopsys and their customers. It is useful for those involved in the design or verification of a complex chip.

  1. On the Relationship Between the Length of Season and Tropical Cyclone Activity in the North Atlantic Basin During the Weather Satellite Era, 1960-2013

    Science.gov (United States)

    Wilson, Robert M.

    2014-01-01

    Officially, the North Atlantic basin tropical cyclone season runs from June 1 through November 30 of each year. During this 183-day interval, the vast majority of tropical cyclone onsets are found to occur. For example, in a study of the 715 tropical cyclones that occurred in the North Atlantic basin during the interval 1945-2010, it was found that about 97 percent of them had their onsets during the conventional hurricane season, with the bulk (78 percent) having had onset during the late summer-early fall months of August, September, and October and with none having had onset in the month of March. For the 2014 hurricane season, it already has had the onset of its first named storm on July 1 (day of year (DOY) 182), Arthur, which formed off the east coast of Florida, rapidly growing into a category-2 hurricane with peak 1-minute sustained wind speed of about 90 kt and striking the coast of North Carolina as a category-2 hurricane on July 3. Arthur is the first hurricane larger than category-1 to strike the United States (U.S.) since the year 2008 when Ike struck Texas as a category-2 hurricane and there has not been a major hurricane (category-3 or larger) to strike the U.S. since Wilma struck Florida as a category-3 hurricane in 2005. Only two category-1 hurricanes struck the U.S. in the year 2012 (Isaac and Sandy, striking Louisiana and New York, respectively) and there were no U.S. land-falling hurricanes in 2013 (also true for the years 1962, 1973, 1978, 1981, 1982, 1990, 1994, 2000, 2001, 2006, 2009, and 2010). In recent years it has been argued that the length of season (LOS), determined as the inclusive elapsed time between the first storm day (FSD) and the last storm day (LSD) of the yearly hurricane season (i.e., when peak 1-minute sustained wind speed of at least 34 kt occurred and the tropical cyclone was not classified as 'extratropical'), has increased in length with the lengthening believed to be due to the FSD occurring sooner and the LSD occurring

  2. Numident Online Verification Utility (NOVU)

    Data.gov (United States)

    Social Security Administration — NOVU is a mainframe application that accesses the NUMIDENT to perform real-time SSN verifications. This program is called by other SSA online programs that serve as...

  3. Formal Verification of Continuous Systems

    DEFF Research Database (Denmark)

    Sloth, Christoffer

    2012-01-01

    to the high complexity of both the dynamical system and the specification. Therefore, there is a need for methods capable of verifying complex specifications of complex systems. The verification of high dimensional continuous dynamical systems is the key to verifying general systems. In this thesis......, an abstraction approach is taken to the verification problem. A method is developed for abstracting continuous dynamical systems by timed automata. This method is based on subdividing the state space into cells by use of subdivisioning functions that are decreasing along the vector field. To allow....... It is shown that dual decomposition can be applied on the problem of generating barrier certificates, resulting in a compositional formulation of the safety verification problem. This makes the barrier certificate method applicable to the verification of high dimensional systems, but at the cost...

  4. FINAL REPORT –INDEPENDENT VERIFICATION SURVEY SUMMARY AND RESULTS FOR THE ARGONNE NATIONAL LABORATORY BUILDING 330 PROJECT FOOTPRINT, ARGONNE, ILLINOIS

    Energy Technology Data Exchange (ETDEWEB)

    ERIKA N. BAILEY

    2012-02-29

    ORISE conducted onsite verification activities of the Building 330 project footprint during the period of June 6 through June 7, 2011. The verification activities included technical reviews of project documents, visual inspections, radiation surface scans, and sampling and analysis. The draft verification report was issued in July 2011 with findings and recommendations. The contractor performed additional evaluations and remediation.

  5. Trajectory Based Behavior Analysis for User Verification

    Science.gov (United States)

    Pao, Hsing-Kuo; Lin, Hong-Yi; Chen, Kuan-Ta; Fadlil, Junaidillah

    Many of our activities on computer need a verification step for authorized access. The goal of verification is to tell apart the true account owner from intruders. We propose a general approach for user verification based on user trajectory inputs. The approach is labor-free for users and is likely to avoid the possible copy or simulation from other non-authorized users or even automatic programs like bots. Our study focuses on finding the hidden patterns embedded in the trajectories produced by account users. We employ a Markov chain model with Gaussian distribution in its transitions to describe the behavior in the trajectory. To distinguish between two trajectories, we propose a novel dissimilarity measure combined with a manifold learnt tuning for catching the pairwise relationship. Based on the pairwise relationship, we plug-in any effective classification or clustering methods for the detection of unauthorized access. The method can also be applied for the task of recognition, predicting the trajectory type without pre-defined identity. Given a trajectory input, the results show that the proposed method can accurately verify the user identity, or suggest whom owns the trajectory if the input identity is not provided.

  6. Stretching position can affect levator scapular muscle activity, length, and cervical range of motion in people with a shortened levator scapulae.

    Science.gov (United States)

    Jeong, Hyo-Jung; Cynn, Heon-Seock; Yi, Chung-Hwi; Yoon, Jang-Whon; Lee, Ji-Hyun; Yoon, Tae-Lim; Kim, Bo-Been

    2017-07-01

    Levator scapulae (LS) muscle stretching exercises are a common method of lengthening a shortened muscle; however, the appropriate stretching position for lengthening the LS in people with a shortened LS remains unclear. The purpose of this study was to compare the effects of different stretching exercise positions on the LS and introduce effective stretching exercise methods to clinicians. Twenty-four university students (12 men, 12 women) with a shortened LS were recruited. LS muscle activity, LS index (LSI), and cervical range of motion (ROM) were measured pre (baseline) and post three different stretching exercise positions (sitting, quadruped, and prone). The LSI and cervical ROM exceeded the minimal detectable change and had significant changes. The LSI was greater in the sitting position than at the baseline (p = 0.01), quadruped position (p Stretching the LS in the sitting position was the most effective exercise for improving LS muscle length and cervical ROM. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Telomere length is short in PCOS and oral contraceptive does not affect the telomerase activity in granulosa cells of patients with PCOS.

    Science.gov (United States)

    Li, Ying; Deng, Bingbing; Ouyang, Nengyong; Yuan, Ping; Zheng, Lingyan; Wang, Wenjun

    2017-07-01

    Our study aimed to investigate the association of telomerase activity (TA) and telomere length (TL) in granulosa cells (GCs) with IVF outcomes of polycystic ovary syndrome (PCOS) patients, and the effects of oral contraceptive pill (OCP) pretreatment on these two parameters. One hundred sixty-three infertile women were enrolled and divided into a PCOS group (n = 65) and a non-PCOS group (n = 98). The PCOS group was further divided into an OCP pretreatment group (n = 35) and a non-OCP pretreatment group (n = 30), a TA PCOS group and 1.118 in non-PCOS group (P = 0.005). The patients with TL ≥1 accounted for 36.9% in PCOS group and 54.1% in non-PCOS group (P = 0.032). The average duration of infertility for PCOS patients was 5 years in TA PCOS patients. Shorter TL was found in PCOS patients. The TA levels did not change significantly in PCOS patients. PCOS patients with a lower TA level and shorter telomeres had an earlier onset of infertility symptoms. No predictive value was found for TA and TL in terms of embryo quality or IVF outcomes in PCOS patients, and no effect OCP pretreatment was observed on either TA and TL.

  8. Diacyltransferase Activity and Chain Length Specificity of Mycobacterium tuberculosis PapA5 in the Synthesis of Alkyl β-Diol Lipids

    Energy Technology Data Exchange (ETDEWEB)

    Touchette, Megan H.; Bommineni, Gopal R.; Delle Bovi, Richard J.; Gadbery, John; Nicora, Carrie D.; Shukla, Anil K.; Kyle, Jennifer E.; Metz, Thomas O.; Martin, Dwight W.; Sampson, Nicole S.; Miller, W. T.; Tonge, Peter J.; Seeliger, Jessica C.

    2015-09-08

    Although classified as Gram-positive bacteria, Corynebacterineae possess an asymmetric outer membrane that imparts structural and thereby physiological similarity to more distantly related Gram-negative bacteria. Like lipopolysaccharide in Gram-negative bacteria, lipids in the outer membrane of Corynebacterineae have been associated with the virulence of pathogenic species such as Mycobacterium tuberculosis (Mtb). For example, Mtb strains that lack long, branched-chain alkyl esters known as dimycocerosates (DIMs) are significantly attenuated in model infections. The resultant interest in the biosynthetic pathway of these unusual virulence factors has led to the elucidation of many of the steps leading to the final esterification of the alkyl beta-diol, phthiocerol, with branched-chain fatty acids know as mycocerosates. PapA5 is an acyltransferase implicated in these final reactions. We here show that PapA5 is indeed the terminal enzyme in DIM biosynthesis by demonstrating its dual esterification activity and chain-length preference using synthetic alkyl beta-diol substrate analogues. Applying these analogues to a series of PapA5 mutants, we also revise a model for the substrate binding within PapA5. Finally, we demonstrate that the Mtb Ser/Thr kinase PknB modifies PapA5 on three Thr residues, including two (T196, T198) located on an unresolved loop. These results clarify the DIM biosynthetic pathway and suggest possible mechanisms by which DIM biosynthesis may be regulated by the post-translational modification of PapA5.

  9. ALMA Science Verification

    Science.gov (United States)

    Hills, R.

    2011-01-01

    As many of you are aware, ALMA has reached a very exciting point in the construction phase. After a year of testing the basic functionality of antennas and small arrays at the Chajnantor site at 5000m, we are now able to run full observations of scientific targets using at least 8 antennas and 4 receiver bands. We recently had a series of reviews of all aspects of the ALMA Project, resulting in a consensus that we will be ready to issue a Call for Proposals for Early Science projects at the end of the first quarter of 2011, with an expectation of starting these Early Science observations toward the end of 2011. ALMA Science Verification is the process by which we will demonstrate that the data that will be produced by ALMA during Early Science is valid. This is done by running full "end to end" tests of ALMA as a telescope. We will observe objects for which similar data are already available for other telescopes. This allows us to make direct quantitative comparisons of all aspects of the data cubes, in order to determine whether the ALMA instrumentation or software is introducing any artifacts.

  10. Solid waste operations complex engineering verification program plan

    Energy Technology Data Exchange (ETDEWEB)

    Bergeson, C.L.

    1994-09-28

    This plan supersedes, but does not replace, the previous Waste Receiving and Processing/Solid Waste Engineering Development Program Plan. In doing this, it does not repeat the basic definitions of the various types or classes of development activities nor provide the rigorous written description of each facility and assign the equipment to development classes. The methodology described in the previous document is still valid and was used to determine the types of verification efforts required. This Engineering Verification Program Plan will be updated on a yearly basis. This EVPP provides programmatic definition of all engineering verification activities for the following SWOC projects: (1) Project W-026 - Waste Receiving and Processing Facility Module 1; (2) Project W-100 - Waste Receiving and Processing Facility Module 2A; (3) Project W-112 - Phase V Storage Facility; and (4) Project W-113 - Solid Waste Retrieval. No engineering verification activities are defined for Project W-112 as no verification work was identified. The Acceptance Test Procedures/Operational Test Procedures will be part of each project`s Title III operation test efforts. The ATPs/OTPs are not covered by this EVPP.

  11. SEMI-AUTOMATIC SPEAKER VERIFICATION SYSTEM

    Directory of Open Access Journals (Sweden)

    E. V. Bulgakova

    2016-03-01

    Full Text Available Subject of Research. The paper presents a semi-automatic speaker verification system based on comparing of formant values, statistics of phone lengths and melodic characteristics as well. Due to the development of speech technology, there is an increased interest now in searching for expert speaker verification systems, which have high reliability and low labour intensiveness because of the automation of data processing for the expert analysis. System Description. We present a description of a novel system analyzing similarity or distinction of speaker voices based on comparing statistics of phone lengths, formant features and melodic characteristics. The characteristic feature of the proposed system based on fusion of methods is a weak correlation between the analyzed features that leads to a decrease in the error rate of speaker recognition. The system advantage is the possibility to carry out rapid analysis of recordings since the processes of data preprocessing and making decision are automated. We describe the functioning methods as well as fusion of methods to combine their decisions. Main Results. We have tested the system on the speech database of 1190 target trials and 10450 non-target trials, including the Russian speech of the male and female speakers. The recognition accuracy of the system is 98.59% on the database containing records of the male speech, and 96.17% on the database containing records of the female speech. It was also experimentally established that the formant method is the most reliable of all used methods. Practical Significance. Experimental results have shown that proposed system is applicable for the speaker recognition task in the course of phonoscopic examination.

  12. Organics Verification Study for Sinclair and Dyes Inlets, Washington

    Energy Technology Data Exchange (ETDEWEB)

    Kohn, Nancy P.; Brandenberger, Jill M.; Niewolny, Laurie A.; Johnston, Robert K.

    2006-09-28

    Sinclair and Dyes Inlets near Bremerton, Washington, are on the State of Washington 1998 303(d) list of impaired waters because of fecal coliform contamination in marine water, metals in sediment and fish tissue, and organics in sediment and fish tissue. Because significant cleanup and source control activities have been conducted in the inlets since the data supporting the 1998 303(d) listings were collected, two verification studies were performed to address the 303(d) segments that were listed for metal and organic contaminants in marine sediment. The Metals Verification Study (MVS) was conducted in 2003; the final report, Metals Verification Study for Sinclair and Dyes Inlets, Washington, was published in March 2004 (Kohn et al. 2004). This report describes the Organics Verification Study that was conducted in 2005. The study approach was similar to the MVS in that many surface sediment samples were screened for the major classes of organic contaminants, and then the screening results and other available data were used to select a subset of samples for quantitative chemical analysis. Because the MVS was designed to obtain representative data on concentrations of contaminants in surface sediment throughout Sinclair Inlet, Dyes Inlet, Port Orchard Passage, and Rich Passage, aliquots of the 160 MVS sediment samples were used in the analysis for the Organics Verification Study. However, unlike metals screening methods, organics screening methods are not specific to individual organic compounds, and are not available for some target organics. Therefore, only the quantitative analytical results were used in the organics verification evaluation. The results of the Organics Verification Study showed that sediment quality outside of Sinclair Inlet is unlikely to be impaired because of organic contaminants. Similar to the results for metals, in Sinclair Inlet, the distribution of residual organic contaminants is generally limited to nearshore areas already within the

  13. NDA techniques for spent fuel verification and radiation monitoring. Report on activities 6a and 6b of Task JNT C799 (SAGOR). Finnish support programme to the IAEA safeguards

    Energy Technology Data Exchange (ETDEWEB)

    Tarvainen, M. [Finnish Centre for Radiation and Nuclear Safety, Helsinki (Finland); Levai, F. [Technical Univ., Budabest (Hungary); Valentine, T.E. [Oak Ridge National Lab., TN (United States); Abhold, M. [Los Alamos National Lab., NM (United States); Moran, B. [USNRC, Washington, DC (United States)

    1997-08-01

    A variety of NDA methods exist for measurement of spent fuel at various stages of the disposition process. Each of the methods has weaknesses and strengths that make them applicable to one or more stages in disposition. Both passive and active methods are, under favorable conditions, capable of providing either a mapping of an assembly to identify missing fuel pins or a measurement of the fissile content and some are capable of providing a mapping of a canister to identify missing assemblies or a measurement of the fissile content. However, a spent fuel measurement system capable of making routine partial defect tests of spent fuel assemblies is missing. The active NDA methods, in particular, the active neutron methods, hold the most promise for providing quantitative measurements on fuel assemblies and canisters. Application of NDA methods to shielded casks may not be practical or even possible due to the extent of radiation attenuation by the shielding materials, and none of these methods are considered to have potential for quantitative measurements once the spent fuel cask has been placed in a repository. The most practical approach to spent fuel verification is to confirm the characteristics of the spent fuel prior to loading in a canister or cask at the conditioning facility. Fissile material tracking systems in addition to containment and surveillance methods have the capability to assure continuity of the verified knowledge of the sample from loading of the canisters to final disposal and closing of the repository. (orig.). 49 refs.

  14. Telomerase activity, telomere length and hTERT DNA methylation in peripheral blood mononuclear cells from monozygotic twins with discordant smoking habits.

    Science.gov (United States)

    Marcon, Francesca; Siniscalchi, Ester; Andreoli, Cristina; Allione, Alessandra; Fiorito, Giovanni; Medda, Emanuela; Guarrera, Simonetta; Matullo, Giuseppe; Crebelli, Riccardo

    2017-10-01

    Increased telomerase expression has been implicated in the pathogenesis of lung cancer and, since the primary cause of lung cancer is smoking, an association between telomerase reactivation and tobacco smoke has been proposed. In this work an investigation has been performed to assess the relationship between tobacco smoke exposure and telomerase activity (TA) in peripheral blood mononuclear cells of healthy smokers. The methylation status of the catalytic subunit of telomerase hTERT was concurrently investigated to assess the possible association between epigenetic modifications of hTERT and TA. Besides, the association between smoke and telomere length (TL) has been evaluated. Healthy monozygotic twins with discordant smoking habits were selected as study population to minimize inter-individual differences because of demographic characteristics and genetic heterogeneity. Statistically significant higher values of TA and TL were observed in smokers compared to nonsmoker co-twins. The multivariate analysis of data showed, besides smoking habits (P = 0.02), an influence of gender (P = 0.006) and BMI (P = 0.001) on TA and a borderline effect of gender (P = 0.05) on TL. DNA methylation analysis, focused on 100 CpG sites mapping in hTERT, highlighted nine CpG sites differentially methylated in smokers. When co-twins were contrasted, selecting as variables the intra-twin difference in TA and hTERT DNA methylation, a statistically significant inverse correlation (P = 0.003) was observed between TA and DNA methylation at the cg05521538 site. In conclusion, these results indicate an association of tobacco smoke with TA and TL and suggest a possible association between smoke-induced epigenetic effects and TA in healthy smokers. Environ. Mol. Mutagen. 58:551-559, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  15. Age verification of the longest lived man in the world.

    Science.gov (United States)

    Gondo, Yasuyuki; Hirose, Nobuyoshi; Yasumoto, Saori; Arai, Yasumichi; Saito, Yasuhiko

    2017-12-01

    Identifying the correct length of life for long-lived individuals is highly important for the social and natural sciences, as well as for policymaking. The purposes of this paper are to propose a standardized age verification procedure and to report on the age verification case of Jiroemon Kimura (J.K.), who is assumed to be the longest lived man in the world. We propose two verification processes that we have named face validity and concurrent validity of age verification. We collected official documents, and non-official records to check face validity. We also gathered life episodes told by J.K. and historical records to evaluate concurrent validity. Although we found several date inconsistencies among documents and mismatches between told episodes and actual dates of events, no critical discordances were discovered. In conclusion, we could verify that J.K. was born on April 19, 1897 and passed away on June 12, 2013 at the age of 116years and 54days. Copyright © 2017. Published by Elsevier Inc.

  16. Neandertal clavicle length

    Science.gov (United States)

    Trinkaus, Erik; Holliday, Trenton W.; Auerbach, Benjamin M.

    2014-01-01

    The Late Pleistocene archaic humans from western Eurasia (the Neandertals) have been described for a century as exhibiting absolutely and relatively long clavicles. This aspect of their body proportions has been used to distinguish them from modern humans, invoked to account for other aspects of their anatomy and genetics, used in assessments of their phylogenetic polarities, and used as evidence for Late Pleistocene population relationships. However, it has been unclear whether the usual scaling of Neandertal clavicular lengths to their associated humeral lengths reflects long clavicles, short humeri, or both. Neandertal clavicle lengths, along with those of early modern humans and latitudinally diverse recent humans, were compared with both humeral lengths and estimated body masses (based on femoral head diameters). The Neandertal do have long clavicles relative their humeri, even though they fall within the ranges of variation of early and recent humans. However, when scaled to body masses, their humeral lengths are relatively short, and their clavicular lengths are indistinguishable from those of Late Pleistocene and recent modern humans. The few sufficiently complete Early Pleistocene Homo clavicles seem to have relative lengths also well within recent human variation. Therefore, appropriately scaled clavicular length seems to have varied little through the genus Homo, and it should not be used to account for other aspects of Neandertal biology or their phylogenetic status. PMID:24616525

  17. Neandertal clavicle length.

    Science.gov (United States)

    Trinkaus, Erik; Holliday, Trenton W; Auerbach, Benjamin M

    2014-03-25

    The Late Pleistocene archaic humans from western Eurasia (the Neandertals) have been described for a century as exhibiting absolutely and relatively long clavicles. This aspect of their body proportions has been used to distinguish them from modern humans, invoked to account for other aspects of their anatomy and genetics, used in assessments of their phylogenetic polarities, and used as evidence for Late Pleistocene population relationships. However, it has been unclear whether the usual scaling of Neandertal clavicular lengths to their associated humeral lengths reflects long clavicles, short humeri, or both. Neandertal clavicle lengths, along with those of early modern humans and latitudinally diverse recent humans, were compared with both humeral lengths and estimated body masses (based on femoral head diameters). The Neandertal do have long clavicles relative their humeri, even though they fall within the ranges of variation of early and recent humans. However, when scaled to body masses, their humeral lengths are relatively short, and their clavicular lengths are indistinguishable from those of Late Pleistocene and recent modern humans. The few sufficiently complete Early Pleistocene Homo clavicles seem to have relative lengths also well within recent human variation. Therefore, appropriately scaled clavicular length seems to have varied little through the genus Homo, and it should not be used to account for other aspects of Neandertal biology or their phylogenetic status.

  18. Biometric Technologies and Verification Systems

    CERN Document Server

    Vacca, John R

    2007-01-01

    Biometric Technologies and Verification Systems is organized into nine parts composed of 30 chapters, including an extensive glossary of biometric terms and acronyms. It discusses the current state-of-the-art in biometric verification/authentication, identification and system design principles. It also provides a step-by-step discussion of how biometrics works; how biometric data in human beings can be collected and analyzed in a number of ways; how biometrics are currently being used as a method of personal identification in which people are recognized by their own unique corporal or behavior

  19. Runtime Verification Through Forward Chaining

    Directory of Open Access Journals (Sweden)

    Alan Perotti

    2014-12-01

    Full Text Available In this paper we present a novel rule-based approach for Runtime Verification of FLTL properties over finite but expanding traces. Our system exploits Horn clauses in implication form and relies on a forward chaining-based monitoring algorithm. This approach avoids the branching structure and exponential complexity typical of tableaux-based formulations, creating monitors with a single state and a fixed number of rules. This allows for a fast and scalable tool for Runtime Verification: we present the technical details together with a working implementation.

  20. Formal verification of mathematical software

    Science.gov (United States)

    Sutherland, D.

    1984-01-01

    Methods are investigated for formally specifying and verifying the correctness of mathematical software (software which uses floating point numbers and arithmetic). Previous work in the field was reviewed. A new model of floating point arithmetic called the asymptotic paradigm was developed and formalized. Two different conceptual approaches to program verification, the classical Verification Condition approach and the more recently developed Programming Logic approach, were adapted to use the asymptotic paradigm. These approaches were then used to verify several programs; the programs chosen were simplified versions of actual mathematical software.

  1. Verification of computational models of cardiac electro-physiology.

    Science.gov (United States)

    Pathmanathan, Pras; Gray, Richard A

    2014-05-01

    For computational models of cardiac activity to be used in safety-critical clinical decision-making, thorough and rigorous testing of the accuracy of predictions is required. The field of 'verification, validation and uncertainty quantification' has been developed to evaluate the credibility of computational predictions. The first stage, verification, is the evaluation of how well computational software correctly solves the underlying mathematical equations. The aim of this paper is to introduce novel methods for verifying multi-cellular electro-physiological solvers, a crucial first stage for solvers to be used with confidence in clinical applications. We define 1D-3D model problems with exact solutions for each of the monodomain, bidomain, and bidomain-with-perfusing-bath formulations of cardiac electro-physiology, which allow for the first time the testing of cardiac solvers against exact errors on fully coupled problems in all dimensions. These problems are carefully constructed so that they can be easily run using a general solver and can be used to greatly increase confidence that an implementation is correct, which we illustrate by testing one major solver, 'Chaste', on the problems. We then perform case studies on calculation verification (also known as solution verification) for two specific applications. We conclude by making several recommendations regarding verification in cardiac modelling. Copyright © 2013 John Wiley & Sons, Ltd.

  2. Algebraic verification of a distributed summation algorithm

    OpenAIRE

    Groote, Jan Friso; Springintveld, J.G.

    1996-01-01

    textabstractIn this note we present an algebraic verification of Segall's Propagation of Information with Feedback (PIF) algorithm. This algorithm serves as a nice benchmark for verification exercises (see [2, 13, 8]). The verification is based on the methodology presented in [7] and demonstrates its applicability to distributed algorithms.

  3. Guidance for the verification and validation of neural networks

    CERN Document Server

    Pullum, L; Darrah, M

    2007-01-01

    Guidance for the Verification and Validation of Neural Networks is a supplement to the IEEE Standard for Software Verification and Validation, IEEE Std 1012-1998. Born out of a need by the National Aeronautics and Space Administration's safety- and mission-critical research, this book compiles over five years of applied research and development efforts. It is intended to assist the performance of verification and validation (V&V) activities on adaptive software systems, with emphasis given to neural network systems. The book discusses some of the difficulties with trying to assure adaptive systems in general, presents techniques and advice for the V&V practitioner confronted with such a task, and based on a neural network case study, identifies specific tasking and recommendations for the V&V of neural network systems.

  4. Telomerase inhibitor imetelstat has preclinical activity across the spectrum of non-small cell lung cancer oncogenotypes in a telomere length dependent manner.

    Science.gov (United States)

    Frink, Robin E; Peyton, Michael; Schiller, Joan H; Gazdar, Adi F; Shay, Jerry W; Minna, John D

    2016-05-31

    Telomerase was evaluated as a therapeutic oncotarget by studying the efficacy of the telomerase inhibitor imetelstat in non-small cell lung cancer (NSCLC) cell lines to determine the range of response phenotypes and identify potential biomarkers of response. A panel of 63 NSCLC cell lines was studied for telomere length and imetelstat efficacy in inhibiting colony formation and no correlation was found with patient characteristics, tumor histology, and oncogenotypes. While there was no overall correlation between imetelstat efficacy with initial telomere length (ranging from 1.5 to 20 kb), the quartile of NSCLC lines with the shortest telomeres was more sensitive than the quartile with the longest telomeres. Continuous long-term treatment with imetelstat resulted in sustained telomerase inhibition, progressive telomere shortening and eventual growth inhibition in a telomere-length dependent manner. Cessation of imetelstat therapy before growth inhibition was followed by telomere regrowth. Likewise, in vivo imetelstat treatment caused tumor xenograft growth inhibition in a telomere-length dependent manner. We conclude from these preclinical studies of telomerase as an oncotarget tested by imetelstat response that imetelstat has efficacy across the entire oncogenotype spectrum of NSCLC, continuous therapy is necessary to prevent telomere regrowth, and short telomeres appears to be the best treatment biomarker.

  5. Program Verification and System Dependability

    Science.gov (United States)

    Jackson, Michael

    Formal verification of program correctness is a long-standing ambition, recently given added prominence by a “Grand Challenge” project. Major emphases have been on the improvement of languages for program specification and program development, and on the construction of verification tools. The emphasis on tools commands general assent, but while some researchers focus on narrow verification aimed only at program correctness, others want to pursue wide verification aimed at the larger goal of system dependability. This paper presents an approach to system dependability based on problem frames and suggests how this approach can be supported by formal software tools. Dependability is to be understood and evaluated in the physical and human problem world of a system. The complexity and non-formal nature of the problem world demand the development and evolution of normal designs and normal design practices for specialised classes of systems and subsystems. The problem frames discipline of systems analysis and development that can support normal design practices is explained and illustrated. The role of formal reasoning in achieving dependability is discussed and some conceptual, linguistic and software tools are suggested.

  6. Ultrasonic verification of composite structures

    NARCIS (Netherlands)

    Pelt, Maurice; de Boer, Robert Jan; Schoemaker, Christiaan; Sprik, Rudolf

    2014-01-01

    Ultrasonic Verification is a new method for the monitoring large surface areas of CFRP by ultrasound with few sensors. The echo response of a transmitted pulse through the structure is compared with the response of an earlier obtained reference signal to calculate a fidelity parameter.

  7. A verification environment for bigraphs

    DEFF Research Database (Denmark)

    Perrone, Gian David; Debois, Søren; Hildebrandt, Thomas

    2013-01-01

    We present the BigMC tool for bigraphical reactive systems that may be instantiated as a verification tool for any formalism or domain-specific modelling language encoded as a bigraphical reactive system. We introduce the syntax and use of BigMC, and exemplify its use with two small examples: a t...

  8. Private Verification for FPGA Bitstreams

    Science.gov (United States)

    2017-03-20

    security risks. Keywords: Trust, Privacy, Hardware Trojan, Hardware Security, ASIC, FPGA, Bitstream Introduction Many effective verification...devices but also to integrate PV-Bit, other Graf Research tools, and other commercial EDA tools into our overarching forward design trust flow philosophy

  9. Improved method for coliform verification.

    OpenAIRE

    Diehl, J D

    1991-01-01

    Modification of a method for coliform verification presented in Standard Methods for the Examination of Water and Wastewater is described. Modification of the method, which is based on beta-galactosidase production, involves incorporation of a lactose operon inducer in medium upon which presumptive coliform isolates are cultured prior to beta-galactosidase assay.

  10. Automated Verification of Virtualized Infrastructures

    DEFF Research Database (Denmark)

    Bleikertz, Sören; Gross, Thomas; Mödersheim, Sebastian Alexander

    2011-01-01

    Virtualized infrastructures and clouds present new challenges for security analysis and formal verification: they are complex environments that continuously change their shape, and that give rise to non-trivial security goals such as isolation and failure resilience requirements. We present...

  11. Experimental verification of proton beam monitoring in a human body by use of activity image of positron-emitting nuclei generated by nuclear fragmentation reaction.

    Science.gov (United States)

    Nishio, Teiji; Miyatake, Aya; Inoue, Kazumasa; Gomi-Miyagishi, Tomoko; Kohno, Ryosuke; Kameoka, Satoru; Nakagawa, Keiichi; Ogino, Takashi

    2008-01-01

    Proton therapy is a form of radiotherapy that enables concentration of dose on a tumor by use of a scanned or modulated Bragg peak. Therefore, it is very important to evaluate the proton-irradiated volume accurately. The proton-irradiated volume can be confirmed by detection of pair-annihilation gamma rays from positron-emitting nuclei generated by the nuclear fragmentation reaction of the incident protons on target nuclei using a PET apparatus. The activity of the positron-emitting nuclei generated in a patient was measured with a PET-CT apparatus after proton beam irradiation of the patient. Activity measurement was performed in patients with tumors of the brain, head and neck, liver, lungs, and sacrum. The 3-D PET image obtained on the CT image showed the visual correspondence with the irradiation area of the proton beam. Moreover, it was confirmed that there were differences in the strength of activity from the PET-CT images obtained at each irradiation site. The values of activity obtained from both measurement and calculation based on the reaction cross section were compared, and it was confirmed that the intensity and the distribution of the activity changed with the start time of the PET imaging after proton beam irradiation. The clinical use of this information about the positron-emitting nuclei will be important for promoting proton treatment with higher accuracy in the future.

  12. INDEPENDENT VERIFICATION SURVEY REPORT FOR ZONE 1 OF THE EAST TENNESSEE TECHNOLOGY PARK IN OAK RIDGE, TENNESSEE

    Energy Technology Data Exchange (ETDEWEB)

    King, David A.

    2012-08-16

    Oak Ridge Associated Universities (ORAU) conducted in-process inspections and independent verification (IV) surveys in support of DOE's remedial efforts in Zone 1 of East Tennessee Technology Park (ETTP) in Oak Ridge, Tennessee. Inspections concluded that the remediation contractor's soil removal and survey objectives were satisfied and the dynamic verification strategy (DVS) was implemented as designed. Independent verification (IV) activities included gamma walkover surveys and soil sample collection/analysis over multiple exposure units (EUs).

  13. INDEPENDENT VERIFICATION OF THE BUILDING 3550 SLAB AT OAK RIDGE NATIONAL LABORATORY OAK RIDGE, TENNESSEE

    Energy Technology Data Exchange (ETDEWEB)

    Weaver, Phyllis C.

    2012-05-08

    The Oak Ridge Institute for Science and Education (ORISE) has completed the independent verification survey of the Building 3550 Slab. The results of this effort are provided. The objective of this verification survey is to provide independent review and field assessment of remediation actions conducted by Safety and Ecology Corporation (SEC) to document that the final radiological condition of the slab meets the release guidelines. Verification survey activities on the Building 3550 Slab that included scans, measurements, and the collection of smears. Scans for alpha, alpha plus beta, and gamma activity identified several areas that were investigated.

  14. Nonintrusive verification attributes for excess fissile materials

    Energy Technology Data Exchange (ETDEWEB)

    Nicholas, N.J.; Eccleston, G.W.; Fearey, B.L. [and others

    1997-10-01

    Under US initiatives, over two hundred metric tons of fissile materials have been declared to be excess to national defense needs. These excess materials are in both classified and unclassified forms. The US has expressed the intent to place these materials under international inspections as soon as practicable. To support these commitments, members of the US technical community are examining a variety of nonintrusive approaches (i.e., those that would not reveal classified or sensitive information) for verification of a range of potential declarations for these classified and unclassified materials. The most troublesome and potentially difficult issues involve approaches for international inspection of classified materials. The primary focus of the work to date has been on the measurement of signatures of relevant materials attributes (e.g., element, identification number, isotopic ratios, etc.), especially those related to classified materials and items. The authors are examining potential attributes and related measurement technologies in the context of possible verification approaches. The paper will discuss the current status of these activities, including their development, assessment, and benchmarking status.

  15. Telomere length and depression

    DEFF Research Database (Denmark)

    Wium-Andersen, Marie Kim; Ørsted, David Dynnes; Rode, Line

    2017-01-01

    as prospectively and genetically. METHOD: Telomere length and three polymorphisms, TERT, TERC and OBFC1, were measured in 67 306 individuals aged 20-100 years from the Danish general population and associated with register-based attendance at hospital for depression and purchase of antidepressant medication.......0-21.5). The genetic analyses suggested that telomere length was not causally associated with attendance at hospital for depression or with purchase of antidepressant medication. CONCLUSIONS: Short telomeres were not associated with depression in prospective or in causal, genetic analyses.......BACKGROUND: Depression has been cross-sectionally associated with short telomeres as a measure of biological age. However, the direction and nature of the association is currently unclear. AIMS: We examined whether short telomere length is associated with depression cross-sectionally as well...

  16. Telomere Length and Mortality

    DEFF Research Database (Denmark)

    Kimura, Masayuki; Hjelmborg, Jacob V B; Gardner, Jeffrey P

    2008-01-01

    Leukocyte telomere length, representing the mean length of all telomeres in leukocytes, is ostensibly a bioindicator of human aging. The authors hypothesized that shorter telomeres might forecast imminent mortality in elderly people better than leukocyte telomere length. They performed mortality...... telomeres predicted the death of the first co-twin better than the mTRFL did (mTRFL: 0.56, 95% confidence interval (CI): 0.49, 0.63; mTRFL(50): 0.59, 95% CI: 0.52, 0.66; mTRFL(25): 0.59, 95% CI: 0.52, 0.66; MTRFL: 0.60, 95% CI: 0.53, 0.67). The telomere-mortality association was stronger in years 3-4 than...

  17. Verification of operational solar flare forecast: Case of Regional Warning Center Japan

    Science.gov (United States)

    Kubo, Yûki; Den, Mitsue; Ishii, Mamoru

    2017-08-01

    In this article, we discuss a verification study of an operational solar flare forecast in the Regional Warning Center (RWC) Japan. The RWC Japan has been issuing four-categorical deterministic solar flare forecasts for a long time. In this forecast verification study, we used solar flare forecast data accumulated over 16 years (from 2000 to 2015). We compiled the forecast data together with solar flare data obtained with the Geostationary Operational Environmental Satellites (GOES). Using the compiled data sets, we estimated some conventional scalar verification measures with 95% confidence intervals. We also estimated a multi-categorical scalar verification measure. These scalar verification measures were compared with those obtained by the persistence method and recurrence method. As solar activity varied during the 16 years, we also applied verification analyses to four subsets of forecast-observation pair data with different solar activity levels. We cannot conclude definitely that there are significant performance differences between the forecasts of RWC Japan and the persistence method, although a slightly significant difference is found for some event definitions. We propose to use a scalar verification measure to assess the judgment skill of the operational solar flare forecast. Finally, we propose a verification strategy for deterministic operational solar flare forecasting. For dichotomous forecast, a set of proposed verification measures is a frequency bias for bias, proportion correct and critical success index for accuracy, probability of detection for discrimination, false alarm ratio for reliability, Peirce skill score for forecast skill, and symmetric extremal dependence index for association. For multi-categorical forecast, we propose a set of verification measures as marginal distributions of forecast and observation for bias, proportion correct for accuracy, correlation coefficient and joint probability distribution for association, the

  18. Verification of an optimized stimulation point on the abdominal wall for transcutaneous neuromuscular electrical stimulation for activation of deep lumbar stabilizing muscles.

    Science.gov (United States)

    Baek, Seung Ok; Cho, Hee Kyung; Jung, Gil Su; Son, Su Min; Cho, Yun Woo; Ahn, Sang Ho

    2014-09-01

    Transcutaneous neuromuscular electrical stimulation (NMES) can stimulate contractions in deep lumbar stabilizing muscles. An optimal protocol has not been devised for the activation of these muscles by NMES, and information is lacking regarding an optimal stimulation point on the abdominal wall. The goal was to determine a single optimized stimulation point on the abdominal wall for transcutaneous NMES for the activation of deep lumbar stabilizing muscles. Ultrasound images of the spinal stabilizing muscles were captured during NMES at three sites on the lateral abdominal wall. After an optimal location for the placement of the electrodes was determined, changes in the thickness of the lumbar multifidus (LM) were measured during NMES. Three stimulation points were investigated using 20 healthy physically active male volunteers. A reference point R, 1 cm superior to the iliac crest along the midaxillary line, was used. Three study points were used: stimulation point S1 was located 2 cm superior and 2 cm medial to the anterior superior iliac spine, stimulation point S3 was 2 cm below the lowest rib along the same sagittal plane as S1, and stimulation point S2 was midway between S1 and S3. Sessions were conducted stimulating at S1, S2, or S3 using R for reference. Real-time ultrasound imaging (RUSI) of the abdominal muscles was captured during each stimulation session. In addition, RUSI images were captured of the LM during stimulation at S1. Thickness, as measured by RUSI, of the transverse abdominis (TrA), obliquus internus, and obliquus externus was greater during NMES than at rest for all three study points (pRUSI. The authors recommend this optimal stimulation point be used for NMES in the course of lumbar spine stabilization training in patients having difficulty initiating contraction of these muscles. Copyright © 2014 Elsevier Inc. All rights reserved.

  19. REVISED FINAL REPORT – INDEPENDENT VERIFICATION SURVEY ACTIVITIES AT THE SEPARATIONS PROCESS RESEARCH UNIT SITES, NISKAYUNA, NEW YORK – DCN 0496-SR-06-1

    Energy Technology Data Exchange (ETDEWEB)

    Evan Harpenau

    2011-10-10

    The Separations Process Research Unit (SPRU) complex located on the Knolls Atomic Power Laboratory (KAPL) site in Niskayuna, New York, was constructed in the late 1940s to research the chemical separation of plutonium and uranium (Figure A-1). SPRU operated as a laboratory scale research facility between February 1950 and October 1953. The research activities ceased following the successful development of the reduction oxidation and plutonium/uranium extraction processes. The oxidation and extraction processes were subsequently developed for large scale use by the Hanford and Savannah River sites (aRc 2008a). Decommissioning of the SPRU facilities began in October 1953 and continued through the 1990s.

  20. Design verification and validation plan for the cold vacuum drying facility

    Energy Technology Data Exchange (ETDEWEB)

    NISHIKAWA, L.D.

    1999-06-03

    The Cold Vacuum Drying Facility (CVDF) provides the required process systems, supporting equipment, and facilities needed for drying spent nuclear fuel removed from the K Basins. This document presents the both completed and planned design verification and validation activities.

  1. The mitogenic activities of phosphatidate are acyl-chain-length dependent and calcium independent in C3H/10T1/2 cells.

    Science.gov (United States)

    Krabak, M J; Hui, S W

    1991-01-01

    Phosphatidates (PA or phosphatidic acid) were shown to have mitogenic properties, including the stimulation of DNA synthesis and calcium mobilization in C3H/10T1/2 cells. Their continuous presence for a minimum of 7 h induced DNA synthesis with kinetics similar to that observed when 10% fetal bovine serum was used as a mitogen. PAs with long chain saturated fatty acid moieties were more mitogenic, in a dose-dependent fashion, than PAs with short saturated or unsaturated fatty acid moieties. When compared with lysostearoyl-PA (LSPA), distearoyl-PA (DSPA) was as potent with respect to the induction of DNA synthesis. Lysooleoyl-PA (LOPA) was slightly more potent than dioleoyl-PA (DOPA), but much weaker than DSPA and LSPA. Preincubation with dilauroyl-PA (DLPA) reduces the mitogenic effect of DSPA by 85%. The pattern of mitogenic inhibition suggests that a chain-length-independent, yet PA-specific, mechanism is involved. Both DSPA and DLPA are equally taken up by the cells after 30 min. LOPA, but not LSPA, produced a large calcium transient (1.3 microM), which we found to be derived from intracellular sources. DSPA, the most mitogenic PA tested, produced a weaker transient (0.6 microM). Interestingly, LSPA did not produce any detectable calcium transient. These results suggest that the chain-length-specific step in the signaling mechanism of PA occurs after the initial chain-length-independent partitioning and/or binding to the membrane and that the induction of DNA synthesis is not related to the observed calcium transients.

  2. Decay Lengths for Diffusive Transport Activated by Andreev Reflections in Al/n-GaAs/Al Superconductor-Semiconductor-Superconductor Junctions

    DEFF Research Database (Denmark)

    Kutchinsky, Jonatan; Taboryski, Rafael Jozef; Clausen, Thomas

    1997-01-01

    In a highly doped GaAs semiconductor with superconducting contacts of Al, clear conductance peaks are observed at zero voltage bias and at V = +/-2 Delta/e, +/-Delta/e. The subharmonic energy gap structure originates from Andreev scattering with diffusive, but energy conserving, transport in the Ga......As. The zero bias excess conductance is due to phase-coherent transport. Both effects are suppressed when the distance between the superconducting electrodes exceeds the inelastic diffusion length in the GaAs normal channel....

  3. Land surface Verification Toolkit (LVT)

    Science.gov (United States)

    Kumar, Sujay V.

    2017-01-01

    LVT is a framework developed to provide an automated, consolidated environment for systematic land surface model evaluation Includes support for a range of in-situ, remote-sensing and other model and reanalysis products. Supports the analysis of outputs from various LIS subsystems, including LIS-DA, LIS-OPT, LIS-UE. Note: The Land Information System Verification Toolkit (LVT) is a NASA software tool designed to enable the evaluation, analysis and comparison of outputs generated by the Land Information System (LIS). The LVT software is released under the terms and conditions of the NASA Open Source Agreement (NOSA) Version 1.1 or later. Land Information System Verification Toolkit (LVT) NOSA.

  4. Verification of the viability of virions detection using neutron activation analysis; Verificacao da viabilidade de deteccao de virions atraves da analise por ativacao com neutrons

    Energy Technology Data Exchange (ETDEWEB)

    Wacha, R.; Silva, A.X. da; Crispim, V.R [Universidade Federal, Rio de Janeiro, RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia. Programa de Engenharia Nuclear; Couceiro, J.N.S.S. [Universidade Federal, Rio de Janeiro, RJ (Brazil). Inst. de Microbiologia Professor Paulo de Goes. Dept. de Virologia

    2002-07-01

    The use of nuclear techniques, as Neutron Activation Analysis, can be an alternative way for the microbiological diagnosis, bringing a significant profit in the analysis time, for not needing pre cultivated samples in appropriate way. In this technique, the samples are collected and submitted to a thermal neutron beam. The interaction of these neutrons with the samples generates gamma rays whose energy spectre is a characteristic of the elemental composition of these samples. Of this done one, a virus presence can be detected in the sample through the distinction of its respective elemental compositions allowing, also, carrying through the analysis in real time. In this work, computational simulations had been become fulfilled using the radiation transport code based on the Monte Carlo Method, MCNP4B, to verify the viability of the application of this system for the virus particle detection in its natural collection environment. (author)

  5. Verification of key odorants in rose oil by gas chromatography-olfactometry/aroma extract dilution analysis, odour activity value and aroma recombination.

    Science.gov (United States)

    Xiao, Zuobing; Li, Jing; Niu, Yunwei; Liu, Qiang; Liu, Junhua

    2017-10-01

    Rose oil is much too expensive but very popular. It's well known that the flower oil's aroma profile hasn't been intensively investigated. In order to verify the aroma profile of rose oil, the synthetic blend of odorants was prepared and then compared with the original rose oil using electronic nose analysis (ENA) combined with quantitative descriptive analysis (QDA). The odorants from rose oils were screened out by Gas Chromatography-Olfactometry/aroma extract dilution analysis (GC-O/AEDA) combined with odour activity value (OAV). Both ENA and QDA indicated the recombination model derived from OAV and GC-O/AEDA closely resembled the original rose oil. The experiment results show that rose oxide, linalool, α-pinene, β-pinene, nonanal, heptanal citronellal, phenyl ethyl alcohol, benzyl alcohol, eugenol, methyl eugenol, β-citronellol, hexyl acetate, β-ionone, nerol, etc. are very important constituent to rose oil aroma profile.

  6. Formal verification of AI software

    Science.gov (United States)

    Rushby, John; Whitehurst, R. Alan

    1989-01-01

    The application of formal verification techniques to Artificial Intelligence (AI) software, particularly expert systems, is investigated. Constraint satisfaction and model inversion are identified as two formal specification paradigms for different classes of expert systems. A formal definition of consistency is developed, and the notion of approximate semantics is introduced. Examples are given of how these ideas can be applied in both declarative and imperative forms.

  7. Kleene Algebra and Bytecode Verification

    Science.gov (United States)

    2016-04-27

    Bytecode 2005 Preliminary Version Kleene Algebra and Bytecode Verification Lucja Kot 1 Dexter Kozen 2 Department of Computer Science Cornell...first-order methods that inductively annotate program points with abstract values. In [6] we introduced a second-order approach based on Kleene algebra ...form a left-handed Kleene algebra . The dataflow labeling is not achieved by inductively labeling the program with abstract values, but rather by

  8. Nuclear Data Verification and Standardization

    Energy Technology Data Exchange (ETDEWEB)

    Karam, Lisa R.; Arif, Muhammad; Thompson, Alan K.

    2011-10-01

    The objective of this interagency program is to provide accurate neutron interaction verification and standardization data for the U.S. Department of Energy Division of Nuclear Physics programs which include astrophysics, radioactive beam studies, and heavy-ion reactions. The measurements made in this program are also useful to other programs that indirectly use the unique properties of the neutron for diagnostic and analytical purposes. These include homeland security, personnel health and safety, nuclear waste disposal, treaty verification, national defense, and nuclear based energy production. The work includes the verification of reference standard cross sections and related neutron data employing the unique facilities and capabilities at NIST and other laboratories as required; leadership and participation in international intercomparisons and collaborations; and the preservation of standard reference deposits. An essential element of the program is critical evaluation of neutron interaction data standards including international coordinations. Data testing of critical data for important applications is included. The program is jointly supported by the Department of Energy and the National Institute of Standards and Technology.

  9. Structure of physical activity in inhabitants of the Moravian-Silesian region between 2005-2009 with regard to formal length of education

    Directory of Open Access Journals (Sweden)

    Igor Fojtík

    2012-03-01

    Full Text Available BACKGROUND: Regular physical activity is an important factor in human health status. The fact, that the physical activity will be regular, is influenced by many internal and external individual factors. Education is considered to be an important factor that influences physical activity. There has not been fully clarified the relationship between physical activity and education in pursuit of regional indicators yet. AIM: The aim of this study was to analyze the physical activity of adult inhabitants of the Moravian-Silesian region with regard to the number of years spent in formal education. METHODS: The research sample consisted of 759 residents of MoravianSilesian region (419 women and 340 men aged 25-58. The IPAQ questionnaire was used to obtain the data, which was distributed by trained university students in the spring and autumn periods of 2005-2009. Kruskal Wallis ANOVA test was used for the statistical evaluation of the data. The effect size was calculated to clarify the internal differences in results. RESULTS: Significant differences in the structure of physical activity were found only in men in the job related physical activity (H = 6.277; p = 0.05; η2 = 0.019 and in vigorous physical activity (H = 6.230; p = 0.05; η2 = 0.018. Physically most active are men with lowest level of education. No significant difference was found in the monitored parameters for women. Job related physical activity means the highest part of the total physical activity in respondents with lowest education. CONCLUSION: The results of the survey point to the fact, that different level of education is not an important factor associated with physical activity in Moravian-Silesian region. To promote physical activity we would recommend focusing on physical activity in leisure time, during transport and on vigorous physical activity in all groups of respondents based on educational level.

  10. Gender verification in competitive sports.

    Science.gov (United States)

    Simpson, J L; Ljungqvist, A; de la Chapelle, A; Ferguson-Smith, M A; Genel, M; Carlson, A S; Ehrhardt, A A; Ferris, E

    1993-11-01

    The possibility that men might masquerade as women and be unfair competitors in women's sports is accepted as outrageous by athletes and the public alike. Since the 1930s, media reports have fuelled claims that individuals who once competed as female athletes subsequently appeared to be men. In most of these cases there was probably ambiguity of the external genitalia, possibly as a result of male pseudohermaphroditism. Nonetheless, beginning at the Rome Olympic Games in 1960, the International Amateur Athletics Federation (IAAF) began establishing rules of eligibility for women athletes. Initially, physical examination was used as a method for gender verification, but this plan was widely resented. Thus, sex chromatin testing (buccal smear) was introduced at the Mexico City Olympic Games in 1968. The principle was that genetic females (46,XX) show a single X-chromatic mass, whereas males (46,XY) do not. Unfortunately, sex chromatin analysis fell out of common diagnostic use by geneticists shortly after the International Olympic Committee (IOC) began its implementation for gender verification. The lack of laboratories routinely performing the test aggravated the problem of errors in interpretation by inexperienced workers, yielding false-positive and false-negative results. However, an even greater problem is that there exist phenotypic females with male sex chromatin patterns (e.g. androgen insensitivity, XY gonadal dysgenesis). These individuals have no athletic advantage as a result of their congenital abnormality and reasonably should not be excluded from competition. That is, only the chromosomal (genetic) sex is analysed by sex chromatin testing, not the anatomical or psychosocial status. For all the above reasons sex chromatin testing unfairly excludes many athletes. Although the IOC offered follow-up physical examinations that could have restored eligibility for those 'failing' sex chromatin tests, most affected athletes seemed to prefer to 'retire'. All

  11. Block 2 SRM conceptual design studies. Volume 1, Book 2: Preliminary development and verification plan

    Science.gov (United States)

    1986-01-01

    Activities that will be conducted in support of the development and verification of the Block 2 Solid Rocket Motor (SRM) are described. Development includes design, fabrication, processing, and testing activities in which the results are fed back into the project. Verification includes analytical and test activities which demonstrate SRM component/subassembly/assembly capability to perform its intended function. The management organization responsible for formulating and implementing the verification program is introduced. It also identifies the controls which will monitor and track the verification program. Integral with the design and certification of the SRM are other pieces of equipment used in transportation, handling, and testing which influence the reliability and maintainability of the SRM configuration. The certification of this equipment is also discussed.

  12. Propagation length enhancement of surface plasmon polaritons in gold nano-/micro-waveguides by the interference with photonic modes in the surrounding active dielectrics

    Directory of Open Access Journals (Sweden)

    Suárez Isaac

    2017-02-01

    Full Text Available In this work, the unique optical properties of surface plasmon polaritons (SPPs, i.e. subwavelength confinement or strong electric field concentration, are exploited to demonstrate the propagation of light signal at 600 nm along distances in the range from 17 to 150 μm for Au nanostripes 500 nm down to 100 nm wide (30 nm of height, respectively, both theoretically and experimentally. A low power laser is coupled into an optical fiber tip that is used to locally excite the photoluminescence of colloidal quantum dots (QDs dispersed in their surroundings. Emitted light from these QDs is generating the SPPs that propagate along the metal waveguides. Then, the above-referred propagation lengths were directly extracted from this novel experimental technique by studying the intensity of light decoupled at the output edge of the waveguide. Furthermore, an enhancement of the propagation length up to 0.4 mm is measured for the 500-nm-wide metal nanostripe, for which this effect is maximum. For this purpose, a simultaneous excitation of the same QDs dispersed in poly(methyl methacrylate waveguides integrated with the metal nanostructures is performed by end-fire coupling an excitation laser energy as low as 1 KW/cm2. The proposed mechanism to explain such enhancement is a non-linear interference effect between dielectric and plasmonic (supermodes propagating in the metal-dielectric structure, which can be apparently seen as an effective amplification or compensation effect of the gain material (QDs over the SPPs, as previously reported in literature. The proposed system and the method to create propagating SPPs in metal waveguides can be of interest for the application field of sensors and optical communications at visible wavelengths, among other applications, using plasmonic interconnects to reduce the dimensions of photonic chips.

  13. PROCEED and Crowd-sourced Formal Verification

    Science.gov (United States)

    2011-11-07

    VA November 7, 2011 PROCEED and Crowd-sourced Formal Verification Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting...TITLE AND SUBTITLE PROCEED and Crowd-sourced Formal Verification 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d... Formal Verification (CSFV) Approved for Public Release, Distribution Unlimited. The Problem Application specific functions Are there fundamental

  14. Formal Verification of Mathematical Software. Volume 2

    Science.gov (United States)

    1990-05-01

    copy RAfJC-TR-90-53, Vol I (of twol Final Techrical Report ?"ay 1990 AD-A223 633 FORMAL VERIFICATION OF MATHEMATICAL SOFTWARE DTIC ELECTE Odyssey...copies of this report unless contractual obligations or notices on a specific document require that it be returned. FORMAL VERIFICATION OF...1 May 1986 Contract Expiration Date: 31 July 1989 Short Title of Work: Formal Verification of SDI Mathematical Software Period of Work Covered: May 86

  15. Automatic Verification of Autonomous Robot Missions

    Science.gov (United States)

    2014-01-01

    for a mission related to the search for a biohazard. Keywords: mobile robots, formal verification , performance guarantees, automatic translation 1...tested. 2 Related Work Formal verification of systems is critical when failure creates a high cost, such as life or death scenarios. A variety of...robot. 3.3 PARS Process algebras are specification languages that allow for formal verification of concurrent systems. Process Algebra for Robot

  16. Verification-based Software-fault Detection

    OpenAIRE

    Gladisch, Christoph David

    2011-01-01

    Software is used in many safety- and security-critical systems. Software development is, however, an error-prone task. In this dissertation new techniques for the detection of software faults (or software "bugs") are described which are based on a formal deductive verification technology. The described techniques take advantage of information obtained during verification and combine verification technology with deductive fault detection and test generation in a very unified way.

  17. Online Signature Verification Using Fourier Descriptors

    Directory of Open Access Journals (Sweden)

    Berrin Yanikoglu

    2009-01-01

    Full Text Available We present a novel online signature verification system based on the Fast Fourier Transform. The advantage of using the Fourier domain is the ability to compactly represent an online signature using a fixed number of coefficients. The fixed-length representation leads to fast matching algorithms and is essential in certain applications. The challenge on the other hand is to find the right preprocessing steps and matching algorithm for this representation. We report on the effectiveness of the proposed method, along with the effects of individual preprocessing and normalization steps, based on comprehensive tests over two public signature databases. We also propose to use the pen-up duration information in identifying forgeries. The best results obtained on the SUSIG-Visual subcorpus and the MCYT-100 database are 6.2% and 12.1% error rate on skilled forgeries, respectively. The fusion of the proposed system with our state-of-the-art Dynamic Time Warping (DTW system lowers the error rate of the DTW system by up to about 25%. While the current error rates are higher than state-of-the-art results for these databases, as an approach using global features, the system possesses many advantages. Considering also the suggested improvements, the FFT system shows promise both as a stand-alone system and especially in combination with approaches that are based on local features.

  18. Towards the Verification of Human-Robot Teams

    Science.gov (United States)

    Fisher, Michael; Pearce, Edward; Wooldridge, Mike; Sierhuis, Maarten; Visser, Willem; Bordini, Rafael H.

    2005-01-01

    Human-Agent collaboration is increasingly important. Not only do high-profile activities such as NASA missions to Mars intend to employ such teams, but our everyday activities involving interaction with computational devices falls into this category. In many of these scenarios, we are expected to trust that the agents will do what we expect and that the agents and humans will work together as expected. But how can we be sure? In this paper, we bring together previous work on the verification of multi-agent systems with work on the modelling of human-agent teamwork. Specifically, we target human-robot teamwork. This paper provides an outline of the way we are using formal verification techniques in order to analyse such collaborative activities. A particular application is the analysis of human-robot teams intended for use in future space exploration.

  19. Towards Formal Verification of a Separation Microkernel

    Science.gov (United States)

    Butterfield, Andrew; Sanan, David; Hinchey, Mike

    2013-08-01

    The best approach to verifying an IMA separation kernel is to use a (fixed) time-space partitioning kernel with a multiple independent levels of separation (MILS) architecture. We describe an activity that explores the cost and feasibility of doing a formal verification of such a kernel to the Common Criteria (CC) levels mandated by the Separation Kernel Protection Profile (SKPP). We are developing a Reference Specification of such a kernel, and are using higher-order logic (HOL) to construct formal models of this specification and key separation properties. We then plan to do a dry run of part of a formal proof of those properties using the Isabelle/HOL theorem prover.

  20. MOV reliability evaluation and periodic verification scheduling

    Energy Technology Data Exchange (ETDEWEB)

    Bunte, B.D.

    1996-12-01

    The purpose of this paper is to establish a periodic verification testing schedule based on the expected long term reliability of gate or globe motor operated valves (MOVs). The methodology in this position paper determines the nominal (best estimate) design margin for any MOV based on the best available information pertaining to the MOVs design requirements, design parameters, existing hardware design, and present setup. The uncertainty in this margin is then determined using statistical means. By comparing the nominal margin to the uncertainty, the reliability of the MOV is estimated. The methodology is appropriate for evaluating the reliability of MOVs in the GL 89-10 program. It may be used following periodic testing to evaluate and trend MOV performance and reliability. It may also be used to evaluate the impact of proposed modifications and maintenance activities such as packing adjustments. In addition, it may be used to assess the impact of new information of a generic nature which impacts safety related MOVs.

  1. NEUTRON ALGORITHM VERIFICATION TESTING

    Energy Technology Data Exchange (ETDEWEB)

    COWGILL,M.; MOSBY,W.; ARGONNE NATIONAL LABORATORY-WEST

    2000-07-19

    Active well coincidence counter assays have been performed on uranium metal highly enriched in {sup 235}U. The data obtained in the present program, together with highly enriched uranium (HEU) metal data obtained in other programs, have been analyzed using two approaches, the standard approach and an alternative approach developed at BNL. Analysis of the data with the standard approach revealed that the form of the relationship between the measured reals and the {sup 235}U mass varied, being sometimes linear and sometimes a second-order polynomial. In contrast, application of the BNL algorithm, which takes into consideration the totals, consistently yielded linear relationships between the totals-corrected reals and the {sup 235}U mass. The constants in these linear relationships varied with geometric configuration and level of enrichment. This indicates that, when the BNL algorithm is used, calibration curves can be established with fewer data points and with more certainty than if a standard algorithm is used. However, this potential advantage has only been established for assays of HEU metal. In addition, the method is sensitive to the stability of natural background in the measurement facility.

  2. Design, Implementation, and Verification of the Reliable Multicast Protocol. Thesis

    Science.gov (United States)

    Montgomery, Todd L.

    1995-01-01

    This document describes the Reliable Multicast Protocol (RMP) design, first implementation, and formal verification. RMP provides a totally ordered, reliable, atomic multicast service on top of an unreliable multicast datagram service. RMP is fully and symmetrically distributed so that no site bears an undue portion of the communications load. RMP provides a wide range of guarantees, from unreliable delivery to totally ordered delivery, to K-resilient, majority resilient, and totally resilient atomic delivery. These guarantees are selectable on a per message basis. RMP provides many communication options, including virtual synchrony, a publisher/subscriber model of message delivery, a client/server model of delivery, mutually exclusive handlers for messages, and mutually exclusive locks. It has been commonly believed that total ordering of messages can only be achieved at great performance expense. RMP discounts this. The first implementation of RMP has been shown to provide high throughput performance on Local Area Networks (LAN). For two or more destinations a single LAN, RMP provides higher throughput than any other protocol that does not use multicast or broadcast technology. The design, implementation, and verification activities of RMP have occurred concurrently. This has allowed the verification to maintain a high fidelity between design model, implementation model, and the verification model. The restrictions of implementation have influenced the design earlier than in normal sequential approaches. The protocol as a whole has matured smoother by the inclusion of several different perspectives into the product development.

  3. The SeaHorn Verification Framework

    Science.gov (United States)

    Gurfinkel, Arie; Kahsai, Temesghen; Komuravelli, Anvesh; Navas, Jorge A.

    2015-01-01

    In this paper, we present SeaHorn, a software verification framework. The key distinguishing feature of SeaHorn is its modular design that separates the concerns of the syntax of the programming language, its operational semantics, and the verification semantics. SeaHorn encompasses several novelties: it (a) encodes verification conditions using an efficient yet precise inter-procedural technique, (b) provides flexibility in the verification semantics to allow different levels of precision, (c) leverages the state-of-the-art in software model checking and abstract interpretation for verification, and (d) uses Horn-clauses as an intermediate language to represent verification conditions which simplifies interfacing with multiple verification tools based on Horn-clauses. SeaHorn provides users with a powerful verification tool and researchers with an extensible and customizable framework for experimenting with new software verification techniques. The effectiveness and scalability of SeaHorn are demonstrated by an extensive experimental evaluation using benchmarks from SV-COMP 2015 and real avionics code.

  4. Turbulence Modeling Verification and Validation

    Science.gov (United States)

    Rumsey, Christopher L.

    2014-01-01

    Computational fluid dynamics (CFD) software that solves the Reynolds-averaged Navier-Stokes (RANS) equations has been in routine use for more than a quarter of a century. It is currently employed not only for basic research in fluid dynamics, but also for the analysis and design processes in many industries worldwide, including aerospace, automotive, power generation, chemical manufacturing, polymer processing, and petroleum exploration. A key feature of RANS CFD is the turbulence model. Because the RANS equations are unclosed, a model is necessary to describe the effects of the turbulence on the mean flow, through the Reynolds stress terms. The turbulence model is one of the largest sources of uncertainty in RANS CFD, and most models are known to be flawed in one way or another. Alternative methods such as direct numerical simulations (DNS) and large eddy simulations (LES) rely less on modeling and hence include more physics than RANS. In DNS all turbulent scales are resolved, and in LES the large scales are resolved and the effects of the smallest turbulence scales are modeled. However, both DNS and LES are too expensive for most routine industrial usage on today's computers. Hybrid RANS-LES, which blends RANS near walls with LES away from walls, helps to moderate the cost while still retaining some of the scale-resolving capability of LES, but for some applications it can still be too expensive. Even considering its associated uncertainties, RANS turbulence modeling has proved to be very useful for a wide variety of applications. For example, in the aerospace field, many RANS models are considered to be reliable for computing attached flows. However, existing turbulence models are known to be inaccurate for many flows involving separation. Research has been ongoing for decades in an attempt to improve turbulence models for separated and other nonequilibrium flows. When developing or improving turbulence models, both verification and validation are important

  5. Code Verification Capabilities and Assessments in Support of ASC V&V Level 2 Milestone #6035

    Energy Technology Data Exchange (ETDEWEB)

    Doebling, Scott William [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Budzien, Joanne Louise [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Ferguson, Jim Michael [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Harwell, Megan Louise [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hickmann, Kyle Scott [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Israel, Daniel M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Magrogan, William Richard III [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Singleton, Jr., Robert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Srinivasan, Gowri [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Walter, Jr, John William [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Woods, Charles Nathan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-09-26

    This document provides a summary of the code verification activities supporting the FY17 Level 2 V&V milestone entitled “Deliver a Capability for V&V Assessments of Code Implementations of Physics Models and Numerical Algorithms in Support of Future Predictive Capability Framework Pegposts.” The physics validation activities supporting this milestone are documented separately. The objectives of this portion of the milestone are: 1) Develop software tools to support code verification analysis; 2) Document standard definitions of code verification test problems; and 3) Perform code verification assessments (focusing on error behavior of algorithms). This report and a set of additional standalone documents serve as the compilation of results demonstrating accomplishment of these objectives.

  6. Numerical Verification of Industrial Numerical Codes

    Directory of Open Access Journals (Sweden)

    Montan Sethy

    2012-04-01

    Full Text Available Several approximations occur during a numerical simulation: physical effects mapy be discarded, continuous functions replaced by discretized ones and real numbers replaced by finite-precision representations. The use of the floating point arithmetic generates round-off errors at each arithmetical expression and some mathematical properties are lost. The aim of the numerical verification activity at EDF R&D is to study the effect of the round-off error propagation on the results of a numerical simulation. It is indeed crucial to perform a numerical verification of industrial codes such as developped at EDF R&D even more for code running in HPC environments. This paper presents some recent studies around the numerical verification at EDF R&D. Le résultat d’un code de simulation numérique subit plusieurs approximations effectuées lors de la modélisation mathématique du problème physique, de la discrétisation du modèle mathématique et de la résolution numérique en arithmétique flottante. L’utilisation de l’arithmétique flottante génère en effet des erreurs d’arrondi lors de chaque opération flottante et des propriétés mathématiques sont perdues. Il existe à EDF R&D une activité transverse de vérification numérique consistant à étudier l’effet de la propagation des erreurs d’arrondi sur les résultats des simulations. Il est en effet important de vérifier numériquement des codes industriels et ce d’autant plus s’ils sont éxécutés dans environnements de calcul haute performance. Ce papier présente des études récentes autour de la vérification numérique à EDF R&D.

  7. Formal Verification at System Level

    Science.gov (United States)

    Mazzini, S.; Puri, S.; Mari, F.; Melatti, I.; Tronci, E.

    2009-05-01

    System Level Analysis calls for a language comprehensible to experts with different background and yet precise enough to support meaningful analyses. SysML is emerging as an effective balance between such conflicting goals. In this paper we outline some the results obtained as for SysML based system level functional formal verification by an ESA/ESTEC study, with a collaboration among INTECS and La Sapienza University of Roma. The study focuses on SysML based system level functional requirements techniques.

  8. Atomistic Simulation of Polymer Crystallization at Realistic Length Scales

    Energy Technology Data Exchange (ETDEWEB)

    Gee, R H; Fried, L E

    2005-01-28

    Understanding the dynamics of polymer crystallization during the induction period prior to crystal growth is a key goal in polymer physics. Here we present the first study of primary crystallization of polymer melts via molecular dynamics simulations at physically realistic (about 46 nm) length scales. Our results show that the crystallization mechanism involves a spinodal decomposition microphase separation caused by an increase in the average length of rigid trans segments along the polymer backbone during the induction period. Further, the characteristic length of the growing dense domains during the induction period is longer than predicted by classical nucleation theory. These results indicate a new 'coexistence period' in the crystallization, where nucleation and growth mechanisms coexist with a phase separation mechanism. Our results provide an atomistic verification of the fringed micelle model.

  9. discouraged by queue length

    Directory of Open Access Journals (Sweden)

    P. R. Parthasarathy

    2001-01-01

    Full Text Available The transient solution is obtained analytically using continued fractions for a state-dependent birth-death queue in which potential customers are discouraged by the queue length. This queueing system is then compared with the well-known infinite server queueing system which has the same steady state solution as the model under consideration, whereas their transient solutions are different. A natural measure of speed of convergence of the mean number in the system to its stationarity is also computed.

  10. Energy-Length Rule

    OpenAIRE

    Mihul, Alexandru C; Mihul, Eleonora A

    2006-01-01

    Lorentz ordering (causality) implies the following rule: for any given energy p0 of a system there is a certain interval c0 on x0 so that their product is the Lorentz ordering constant L It means p0c0 = L. The constant L=hc. Hence Planck constant h in a similar way as c are both consequences of Lorentz metric. The basic ideas are: 1. Lorentz metric implies that x0 must represent a length like the other components of x in X 2. The dual metric space X* is well defined since the Lorentz metric t...

  11. Particularities of Verification Processes for Distributed Informatics Applications

    Directory of Open Access Journals (Sweden)

    Ion IVAN

    2013-01-01

    Full Text Available This paper presents distributed informatics applications and characteristics of their development cycle. It defines the concept of verification and there are identified the differences from software testing. Particularities of the software testing and software verification processes are described. The verification steps and necessary conditions are presented and there are established influence factors of quality verification. Software optimality verification is analyzed and some metrics are defined for the verification process.

  12. Repair activity of oxidatively damaged DNA and telomere length in human lung epithelial cells after exposure to multi-walled carbon nanotubes

    DEFF Research Database (Denmark)

    Borghini, Andrea; Roursgaard, Martin; Andreassi, Maria Grazia

    2017-01-01

    the cells toward replicative senescence, assessed by attrition of telomeres. To investigate this, H2O2 and KBrO3 were used to induce DNA damage in the cells and the effect of pre-exposure to MWCNT tested for a change in repair activity inside the cells or in the extract of treated cells. The effect of MWCNT...... at times longer than 24h, but this decrease was not concentration dependent. The results suggest that the seemingly low mutagenicity of CNTs in cultured cells may be associated with an increased DNA repair activity and a replicative senescence, which may counteract the manifestation of DNA lesions...... in cultured cells, whereas these materials appear to induce low or no mutagenicity. Therefore, the present study aimed to investigate whether in vitro exposure of cultured airway epithelial cells (A549) to multi-walled CNTs (MWCNTs) could increase the DNA repair activity of oxidatively damaged DNA and drive...

  13. On Verification Modelling of Embedded Systems

    NARCIS (Netherlands)

    Brinksma, Hendrik; Mader, Angelika H.

    Computer-aided verification of embedded systems hinges on the availability of good verification models of the systems at hand. Such models must be much simpler than full design models or specifications to be of practical value, because of the unavoidable combinatorial complexities in the

  14. 9 CFR 417.8 - Agency verification.

    Science.gov (United States)

    2010-01-01

    ... ANALYSIS AND CRITICAL CONTROL POINT (HACCP) SYSTEMS § 417.8 Agency verification. FSIS will verify the adequacy of the HACCP plan(s) by determining that each HACCP plan meets the requirements of this part and all other applicable regulations. Such verification may include: (a) Reviewing the HACCP plan; (b...

  15. On the organisation of program verification competitions

    NARCIS (Netherlands)

    Huisman, Marieke; Klebanov, Vladimir; Monahan, Rosemary; Klebanov, Vladimir; Beckert, Bernhard; Biere, Armin; Sutcliffe, Geoff

    In this paper, we discuss the challenges that have to be addressed when organising program verification competitions. Our focus is on competitions for verification systems where the participants both formalise an informally stated requirement and (typically) provide some guidance for the tool to

  16. 78 FR 58492 - Generator Verification Reliability Standards

    Science.gov (United States)

    2013-09-24

    ... Synchronous Condenser Reactive Power Capability), MOD- 026-1 (Verification of Models and Data for Generator... (Verification and Data Reporting of Generator Real and Reactive Power Capability and Synchronous Condenser... Registry, NERC has registered 901 generator owners within the United States. Currently, synchronous...

  17. A correlation-based fingerprint verification system

    NARCIS (Netherlands)

    Bazen, A.M.; Gerez, Sabih H.; Veelenturf, L.P.J.; van der Zwaag, B.J.; Verwaaijen, G.T.B.

    In this paper, a correlation-based fingerprint verification system is presented. Unlike the traditional minutiae-based systems, this system directly uses the richer gray-scale information of the fingerprints. The correlation-based fingerprint verification system first selects appropriate templates

  18. A Model for Collaborative Runtime Verification

    NARCIS (Netherlands)

    Testerink, Bas; Bulling, Nils; Dastani, Mehdi

    2015-01-01

    Runtime verification concerns checking whether a system execution satisfies a given property. In this paper we propose a model for collaborative runtime verification where a network of local monitors collaborates in order to verify properties of the system. A local monitor has only a local view on

  19. Quantitative reactive modeling and verification.

    Science.gov (United States)

    Henzinger, Thomas A

    Formal verification aims to improve the quality of software by detecting errors before they do harm. At the basis of formal verification is the logical notion of correctness, which purports to capture whether or not a program behaves as desired. We suggest that the boolean partition of software into correct and incorrect programs falls short of the practical need to assess the behavior of software in a more nuanced fashion against multiple criteria. We therefore propose to introduce quantitative fitness measures for programs, specifically for measuring the function, performance, and robustness of reactive programs such as concurrent processes. This article describes the goals of the ERC Advanced Investigator Project QUAREM. The project aims to build and evaluate a theory of quantitative fitness measures for reactive models. Such a theory must strive to obtain quantitative generalizations of the paradigms that have been success stories in qualitative reactive modeling, such as compositionality, property-preserving abstraction and abstraction refinement, model checking, and synthesis. The theory will be evaluated not only in the context of software and hardware engineering, but also in the context of systems biology. In particular, we will use the quantitative reactive models and fitness measures developed in this project for testing hypotheses about the mechanisms behind data from biological experiments.

  20. Cognitive Bias in Systems Verification

    Science.gov (United States)

    Larson, Steve

    2012-01-01

    Working definition of cognitive bias: Patterns by which information is sought and interpreted that can lead to systematic errors in decisions. Cognitive bias is used in diverse fields: Economics, Politics, Intelligence, Marketing, to name a few. Attempts to ground cognitive science in physical characteristics of the cognitive apparatus exceed our knowledge. Studies based on correlations; strict cause and effect is difficult to pinpoint. Effects cited in the paper and discussed here have been replicated many times over, and appear sound. Many biases have been described, but it is still unclear whether they are all distinct. There may only be a handful of fundamental biases, which manifest in various ways. Bias can effect system verification in many ways . Overconfidence -> Questionable decisions to deploy. Availability -> Inability to conceive critical tests. Representativeness -> Overinterpretation of results. Positive Test Strategies -> Confirmation bias. Debiasing at individual level very difficult. The potential effect of bias on the verification process can be managed, but not eliminated. Worth considering at key points in the process.

  1. RISKIND verification and benchmark comparisons

    Energy Technology Data Exchange (ETDEWEB)

    Biwer, B.M.; Arnish, J.J.; Chen, S.Y.; Kamboj, S.

    1997-08-01

    This report presents verification calculations and benchmark comparisons for RISKIND, a computer code designed to estimate potential radiological consequences and health risks to individuals and the population from exposures associated with the transportation of spent nuclear fuel and other radioactive materials. Spreadsheet calculations were performed to verify the proper operation of the major options and calculational steps in RISKIND. The program is unique in that it combines a variety of well-established models into a comprehensive treatment for assessing risks from the transportation of radioactive materials. Benchmark comparisons with other validated codes that incorporate similar models were also performed. For instance, the external gamma and neutron dose rate curves for a shipping package estimated by RISKIND were compared with those estimated by using the RADTRAN 4 code and NUREG-0170 methodology. Atmospheric dispersion of released material and dose estimates from the GENII and CAP88-PC codes. Verification results have shown the program to be performing its intended function correctly. The benchmark results indicate that the predictions made by RISKIND are within acceptable limits when compared with predictions from similar existing models.

  2. Workgroup for Hydraulic laboratory Testing and Verification of Hydroacoustic Instrumentation

    Science.gov (United States)

    Fulford, Janice M.; Armstrong, Brandy N.; Thibodeaux, Kirk G.

    2015-01-01

    An international workgroup was recently formed for hydraulic laboratory testing and verification of hydroacoustic instrumentation used for water velocity measurements. The activities of the workgroup have included one face to face meeting, conference calls and an inter-laboratory exchange of two acoustic meters among participating laboratories. Good agreement was found among four laboratories at higher tow speeds and poorer agreement at the lowest tow speed.

  3. Kinetic analysis of anionic surfactant adsorption from aqueous solution onto activated carbon and layered double hydroxide with the zero length column method

    NARCIS (Netherlands)

    Schouten, N.; van der Ham, Aloysius G.J.; Euverink, G.J.W.; de Haan, A.B.

    2009-01-01

    Low cost adsorption technology offers high potential to clean-up laundry rinsing water. From an earlier selection of adsorbents, layered double hydroxide (LDH) and granular activated carbon (GAC) proved to be interesting materials for the removal of anionic surfactant, linear alkyl benzene sulfonate

  4. Comparing formal verification approaches of interlocking systems

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth; Nguyen, Hoang Nga; Roggenbach, Markus

    2016-01-01

    The verification of railway interlocking systems is a challenging task, and therefore several research groups have suggested to improve this task by using formal methods, but they use different modelling and verification approaches. To advance this research, there is a need to compare these appro......The verification of railway interlocking systems is a challenging task, and therefore several research groups have suggested to improve this task by using formal methods, but they use different modelling and verification approaches. To advance this research, there is a need to compare...... these approaches. As a first step towards this, in this paper we suggest a way to compare different formal approaches for verifying designs of route-based interlocking systems and we demonstrate it on modelling and verification approaches developed within the research groups at DTU/Bremen and at Surrey...

  5. Influenza activity in Europe during eight seasons (1999-2007): an evaluation of the indicators used to measure activity and an assessment of the timing, length and course of peak activity (spread) across Europe.

    NARCIS (Netherlands)

    Paget, J.; Marquet, R.; Meijer, A.; Velden, L. van der

    2007-01-01

    BACKGROUND: The European Influenza Surveillance Scheme (EISS) has collected clinical and virological data on influenza since 1996 in an increasing number of countries. The EISS dataset was used to characterise important epidemiological features of influenza activity in Europe during eight winters

  6. BEval: A Plug-in to Extend Atelier B with Current Verification Technologies

    Directory of Open Access Journals (Sweden)

    Valério Medeiros Jr.

    2014-01-01

    Full Text Available This paper presents BEval, an extension of Atelier B to improve automation in the verification activities in the B method or Event-B. It combines a tool for managing and verifying software projects (Atelier B and a model checker/animator (ProB so that the verification conditions generated in the former are evaluated with the latter. In our experiments, the two main verification strategies (manual and automatic showed significant improvement as ProB's evaluator proves complementary to Atelier B built-in provers. We conducted experiments with the B model of a micro-controller instruction set; several verification conditions, that we were not able to discharge automatically or manually with AtelierB's provers, were automatically verified using BEval.

  7. Gender verification of female athletes.

    Science.gov (United States)

    Elsas, L J; Ljungqvist, A; Ferguson-Smith, M A; Simpson, J L; Genel, M; Carlson, A S; Ferris, E; de la Chapelle, A; Ehrhardt, A A

    2000-01-01

    The International Olympic Committee (IOC) officially mandated gender verification for female athletes beginning in 1968 and continuing through 1998. The rationale was to prevent masquerading males and women with "unfair, male-like" physical advantage from competing in female-only events. Visual observation and gynecological examination had been tried on a trial basis for two years at some competitions leading up to the 1968 Olympic Games, but these invasive and demeaning processes were jettisoned in favor of laboratory-based genetic tests. Sex chromatin and more recently DNA analyses for Y-specific male material were then required of all female athletes immediately preceding IOC-sanctioned sporting events, and many other international and national competitions following the IOC model. On-site gender verification has since been found to be highly discriminatory, and the cause of emotional trauma and social stigmatization for many females with problems of intersex who have been screened out from competition. Despite compelling evidence for the lack of scientific merit for chromosome-based screening for gender, as well as its functional and ethical inconsistencies, the IOC persisted in its policy for 30 years. The coauthors of this manuscript have worked with some success to rescind this policy through educating athletes and sports governors regarding the psychological and physical nature of sexual differentiation, and the inequities of genetic sex testing. In 1990, the International Amateur Athletics Federation (IAAF) called for abandonment of required genetic screening of women athletes, and by 1992 had adopted a fairer, medically justifiable model for preventing only male "impostors" in international track and field. At the recent recommendation of the IOC Athletes Commission, the Executive Board of the IOC has finally recognized the medical and functional inconsistencies and undue costs of chromosome-based methods. In 1999, the IOC ratified the abandonment of on

  8. A Cache System Design for CMPs with Built-In Coherence Verification

    Directory of Open Access Journals (Sweden)

    Mamata Dalui

    2016-01-01

    Full Text Available This work reports an effective design of cache system for Chip Multiprocessors (CMPs. It introduces built-in logic for verification of cache coherence in CMPs realizing directory based protocol. It is developed around the cellular automata (CA machine, invented by John von Neumann in the 1950s. A special class of CA referred to as single length cycle 2-attractor cellular automata (TACA has been planted to detect the inconsistencies in cache line states of processors’ private caches. The TACA module captures coherence status of the CMPs’ cache system and memorizes any inconsistent recording of the cache line states during the processors’ reference to a memory block. Theory has been developed to empower a TACA to analyse the cache state updates and then to settle to an attractor state indicating quick decision on a faulty recording of cache line status. The introduction of segmentation of the CMPs’ processor pool ensures a better efficiency, in determining the inconsistencies, by reducing the number of computation steps in the verification logic. The hardware requirement for the verification logic points to the fact that the overhead of proposed coherence verification module is much lesser than that of the conventional verification units and is insignificant with respect to the cost involved in CMPs’ cache system.

  9. Task-specific style verification

    Science.gov (United States)

    Pataki, Norbert; Cséri, Tamás; Szügyi, Zalán

    2012-09-01

    Programming antipatterns are commonly used patterns that make the code unnecessary complex and unmaintainable. However, beginner programmers such as students, often use them. Usage of antipatterns should be eliminated from source code. Many antipatterns can be detected at compilation-time with an appropriate parser tool. In this paper we argue for a new lint-like tool that does detect typical programming antipatterns, and it is extensible to task-specific verifications. This tool mainly developed to evaluate students' programs, however it can be used in industrial projects as well. Our approach based on pattern matching on abstract syntax tree provided by Clang parser. We present our description language that specifies the antipatterns.

  10. SU-E-J-138: On the Ion Beam Range and Dose Verification in Hadron Therapy Using Sound Waves

    Energy Technology Data Exchange (ETDEWEB)

    Fourkal, E [Fox Chase Cancer Center, Philadelphia, PA (United States); Allegheny General Hospital, Pittsburgh, PA (United States); Veltchev, I [Fox Chase Cancer Center, Philadelphia, PA (United States); Gayou, O [Allegheny General Hospital, Pittsburgh, PA (United States); Nahirnyak, V [Bukovinian State Medical University, Chernivtsi (Ukraine)

    2015-06-15

    Purpose: Accurate range verification is of great importance to fully exploit the potential benefits of ion beam therapies. Current research efforts on this topic include the use of PET imaging of induced activity, detection of emerging prompt gamma rays or secondary particles. It has also been suggested recently to detect the ultrasound waves emitted through the ion energy absorption process. The energy absorbed in a medium is dissipated as heat, followed by thermal expansion that leads to generation of acoustic waves. By using an array of ultrasound transducers the precise spatial location of the Bragg peak can be obtained. The shape and intensity of the emitted ultrasound pulse depend on several variables including the absorbed energy and the pulse length. The main objective of this work is to understand how the ultrasound wave amplitude and shape depend on the initial ion energy and intensity. This would help guide future experiments in ionoacoustic imaging. Methods: The absorbed energy density for protons and carbon ions of different energy and field sizes were obtained using Fluka Monte Carlo code. Subsequently, the system of coupled equations for temperature and pressure is solved for different ion pulse intensities and lengths to obtain the pressure wave shape, amplitude and spectral distribution. Results: The proposed calculations show that the excited pressure wave amplitude is proportional to the absorbed energy density and for longer ion pulses inversely proportional to the ion pulse duration. It is also shown that the resulting ionoacoustic pressure distribution depends on both ion pulse duration and time between the pulses. Conclusion: The Bragg peak localization using ionoacoustic signal may eventually lead to the development of an alternative imaging method with sub-millimeter resolution. It may also open a way for in-vivo dose verification from the measured acoustic signal.

  11. Formal verification of algorithms for critical systems

    Science.gov (United States)

    Rushby, John M.; Von Henke, Friedrich

    1993-01-01

    We describe our experience with formal, machine-checked verification of algorithms for critical applications, concentrating on a Byzantine fault-tolerant algorithm for synchronizing the clocks in the replicated computers of a digital flight control system. First, we explain the problems encountered in unsynchronized systems and the necessity, and criticality, of fault-tolerant synchronization. We give an overview of one such algorithm, and of the arguments for its correctness. Next, we describe a verification of the algorithm that we performed using our EHDM system for formal specification and verification. We indicate the errors we found in the published analysis of the algorithm, and other benefits that we derived from the verification. Based on our experience, we derive some key requirements for a formal specification and verification system adequate to the task of verifying algorithms of the type considered. Finally, we summarize our conclusions regarding the benefits of formal verification in this domain, and the capabilities required of verification systems in order to realize those benefits.

  12. Δ6-fatty acid desaturase and fatty acid elongase mRNA expression, phagocytic activity and weight-to-length relationships in channel catfish (Ictalurus punctatus) fed alternative diets with soy oil and a probiotic.

    Science.gov (United States)

    Santerre, A; Téllez-Bañuelos, M C; Casas-Solís, J; Castro-Félix, P; Huízar-López, M R; Zaitseva, G P; Horta-Fernández, J L; Trujillo-García, E A; de la Mora-Sherer, D; Palafox-Luna, J A; Juárez-Carrillo, E

    2015-09-22

    A time-course feeding trial was conducted for 120 days on juvenile channel catfish (Ictalurus punctatus) to study the effects of diets differing in oil source (fish oil or soy oil) and supplementation with a commercial probiotic. Relative levels of Δ6-fatty acid desaturase (Δ6-FAD) and fatty acid elongase (FAE) expression were assessed in brain and liver tissues. Both genes showed similar expression levels in all groups studied. Fish weight-to-length relationships were evaluated using polynomial regression analyses, which identified a burst in weight and length in the channel catfish on day 105 of treatment; this increase was related to an increase in gene expression. Mid-intestinal lactic acid bacterium (LAB) count was determined according to morphological and biochemical criteria using API strips. There was no indication that intestinal LAB count was affected by the modified diets. The Cunningham glass adherence method was applied to evaluate phagocytic cell activity in peripheral blood. Reactive oxygen species (ROS) generation was assessed through the respiratory burst activity of spleen macrophages by the NBT reduction test. Probiotic-supplemented diets provided a good substrate for innate immune system function; the phagocytic index was significantly enhanced in fish fed soy oil and the probiotic, and at the end of the experimental period, ROS production increased in fish fed soy oil. The substitution of fish oil by soy oil is recommended for food formulation and will contribute to promoting sustainable aquaculture. Probiotics are also recommended for channel catfish farming as they may act as immunonutrients.

  13. Code Verification of the HIGRAD Computational Fluid Dynamics Solver

    Energy Technology Data Exchange (ETDEWEB)

    Van Buren, Kendra L. [Los Alamos National Laboratory; Canfield, Jesse M. [Los Alamos National Laboratory; Hemez, Francois M. [Los Alamos National Laboratory; Sauer, Jeremy A. [Los Alamos National Laboratory

    2012-05-04

    The purpose of this report is to outline code and solution verification activities applied to HIGRAD, a Computational Fluid Dynamics (CFD) solver of the compressible Navier-Stokes equations developed at the Los Alamos National Laboratory, and used to simulate various phenomena such as the propagation of wildfires and atmospheric hydrodynamics. Code verification efforts, as described in this report, are an important first step to establish the credibility of numerical simulations. They provide evidence that the mathematical formulation is properly implemented without significant mistakes that would adversely impact the application of interest. Highly accurate analytical solutions are derived for four code verification test problems that exercise different aspects of the code. These test problems are referred to as: (i) the quiet start, (ii) the passive advection, (iii) the passive diffusion, and (iv) the piston-like problem. These problems are simulated using HIGRAD with different levels of mesh discretization and the numerical solutions are compared to their analytical counterparts. In addition, the rates of convergence are estimated to verify the numerical performance of the solver. The first three test problems produce numerical approximations as expected. The fourth test problem (piston-like) indicates the extent to which the code is able to simulate a 'mild' discontinuity, which is a condition that would typically be better handled by a Lagrangian formulation. The current investigation concludes that the numerical implementation of the solver performs as expected. The quality of solutions is sufficient to provide credible simulations of fluid flows around wind turbines. The main caveat associated to these findings is the low coverage provided by these four problems, and somewhat limited verification activities. A more comprehensive evaluation of HIGRAD may be beneficial for future studies.

  14. Privacy Preserving Iris Based Biometric Identity Verification

    Directory of Open Access Journals (Sweden)

    Przemyslaw Strzelczyk

    2011-08-01

    Full Text Available Iris biometrics is considered one of the most accurate and robust methods of identity verification. Individually unique iris features can be presented in a compact binary form easily compared with reference template to confirm identity. However, when templates or features are disclosed, iris biometrics is no longer suitable for verification. Therefore, there is a need to perform iris feature matching without revealing the features itself and reference template. The paper proposes an extension of the standard iris-based verification protocol that introduces features and a template locking mechanism, which guarantees that no sensitive information is exposed.Article in English

  15. Expression of Telomeres in Astrocytoma WHO Grade 2 to 4: TERRA Level Correlates with Telomere Length, Telomerase Activity, and Advanced Clinical Grade12

    Science.gov (United States)

    Sampl, Sandra; Pramhas, Sibylle; Stern, Christian; Preusser, Matthias; Marosi, Christine; Holzmann, Klaus

    2012-01-01

    Cancer cells bypass replicative senescence, the major barrier to tumor progression, by using telomerase or alternative lengthening of telomeres (ALT) as telomere maintenance mechanisms (TMMs). Correlation between ALT and patient survival was demonstrated for high-grade astrocytomas. Transcription from subtelomeres produces telomeric repeat-containing RNA (TERRA), a natural inhibitor of telomerase activity (TA). This led us to evaluate correlations of TERRA and TMM with tumor grade and outcome in astrocytoma patients. SYBR Green real-time reverse transcription-polymerase chain reaction assays for quantitation of total and chromosome 2p and 18p specific TERRA levels were developed. Tumor samples from 46 patients with astrocytoma grade 2 to 4, tissue controls, and cell lines were assessed. TMMs were evaluated by measuring TA and by detecting long telomeres due to ALT. In glioblastoma multiforme (GBM) grade 4, total TERRA levels were similar to cell lines but 14-, 31-, and 313-fold lower compared with grade 3, grade 2, and nonmalignant tissue, respectively. Total TERRA levels differed from chromosomal levels. Low 2p TERRA levels correlated with dense promoter methylation of subtelomeric CpG islands, indicating that TERRA expression in gliomas may be chromosome specific and epigenetically regulated. Total TERRA levels correlated with diagnosis, with low or absent TA and the presence of ALT, and were tentatively associated with favorable patient prognosis in our cohort (P = .06). TA and short telomeres identified a subset of GBM with a median survival of only 14.8 months. TERRA and TA may be prognostic in astrocytic tumors. PMID:22348177

  16. Expression of telomeres in astrocytoma WHO grade 2 to 4: TERRA level correlates with telomere length, telomerase activity, and advanced clinical grade.

    Science.gov (United States)

    Sampl, Sandra; Pramhas, Sibylle; Stern, Christian; Preusser, Matthias; Marosi, Christine; Holzmann, Klaus

    2012-02-01

    Cancer cells bypass replicative senescence, the major barrier to tumor progression, by using telomerase or alternative lengthening of telomeres (ALT) as telomere maintenance mechanisms (TMMs). Correlation between ALT and patient survival was demonstrated for high-grade astrocytomas. Transcription from subtelomeres produces telomeric repeat-containing RNA (TERRA), a natural inhibitor of telomerase activity (TA). This led us to evaluate correlations of TERRA and TMM with tumor grade and outcome in astrocytoma patients. SYBR Green real-time reverse transcription-polymerase chain reaction assays for quantitation of total and chromosome 2p and 18p specific TERRA levels were developed. Tumor samples from 46 patients with astrocytoma grade 2 to 4, tissue controls, and cell lines were assessed. TMMs were evaluated by measuring TA and by detecting long telomeres due to ALT. In glioblastoma multiforme (GBM) grade 4, total TERRA levels were similar to cell lines but 14-, 31-, and 313-fold lower compared with grade 3, grade 2, and nonmalignant tissue, respectively. Total TERRA levels differed from chromosomal levels. Low 2p TERRA levels correlated with dense promoter methylation of subtelomeric CpG islands, indicating that TERRA expression in gliomas may be chromosome specific and epigenetically regulated. Total TERRA levels correlated with diagnosis, with low or absent TA and the presence of ALT, and were tentatively associated with favorable patient prognosis in our cohort (P = .06). TA and short telomeres identified a subset of GBM with a median survival of only 14.8 months. TERRA and TA may be prognostic in astrocytic tumors.

  17. Carbon Nanotubes: Measuring Dispersion and Length

    Energy Technology Data Exchange (ETDEWEB)

    Fagan, Jeffrey A.; Bauer, Barry J.; Hobbie, Erik K.; Becker, Matthew L.; Hight-Walker, Angela; Simpson, Jeffrey R.; Chun, Jaehun; Obrzut, Jan; Bajpai, Vardhan; Phelan, Fred R.; Simien, Daneesh; Yeon Huh, Ji; Migler, Kalman B.

    2011-03-01

    Advanced technological uses of single-wall carbon nanotubes (SWCNTs) rely on the production of single length and chirality populations that are currently only available through liquid phase post processing. The foundation of all of these processing steps is the attainment of individualized nanotube dispersion in solution; an understanding of the collodial properties of the dispersed SWCNTs can then be used to designed appropriate conditions for separations. In many instances nanotube size, particularly length, is especially active in determining the achievable properties from a given population, and thus there is a critical need for measurement technologies for both length distribution and effective separation techniques. In this Progress Report, we document the current state of the art for measuring dispersion and length populations, including separations, and use examples to demonstrate the desirability of addressing these parameters.

  18. Integrated safety management system verification: Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Christensen, R.F.

    1998-08-12

    Department of Energy (DOE) Policy (P) 450.4, Safety Management System Policy, commits to institutionalizing an Integrated Safety Management System (ISMS) throughout the DOE complex. The DOE Acquisition Regulations (DEAR 48 CFR 970) requires contractors to manage and perform work in accordance with a documented Integrated Safety Management System. The Manager, Richland Operations Office (RL), initiated a combined Phase 1 and Phase 2 Integrated Safety Management Verification review to confirm that PNNL had successfully submitted a description of their ISMS and had implemented ISMS within the laboratory facilities and processes. A combined review was directed by the Manager, RL, based upon the progress PNNL had made in the implementation of ISM. This report documents the results of the review conducted to verify: (1) that the PNNL integrated safety management system description and enabling documents and processes conform to the guidance provided by the Manager, RL; (2) that corporate policy is implemented by line managers; (3) that PNNL has provided tailored direction to the facility management; and (4) the Manager, RL, has documented processes that integrate their safety activities and oversight with those of PNNL. The general conduct of the review was consistent with the direction provided by the Under Secretary`s Draft Safety Management System Review and Approval Protocol. The purpose of this review was to provide the Manager, RL, with a recommendation to the adequacy of the ISMS description of the Pacific Northwest Laboratory based upon compliance with the requirements of 49 CFR 970.5204(-2 and -78); and, to provide an evaluation of the extent and maturity of ISMS implementation within the Laboratory. Further, this review was intended to provide a model for other DOE Laboratories. In an effort to reduce the time and travel costs associated with ISM verification the team agreed to conduct preliminary training and orientation electronically and by phone. These

  19. Full Length Research Article

    African Journals Online (AJOL)

    Administrator

    engines to give good performance. Key words: Ethyl ester, synthesis, catalytic activity, common oils, biodiesel potential. INTRODUCTION. Reaction of a low molecular weight alcohol (usually methanol to butanol) with either fresh or used vegetable oil/fat is an industrial chemical process that transforms the triglyceride esters ...

  20. Flammable Gas Refined Safety Analysis Tool Software Verification and Validation Report for Resolve Version 2.5

    Energy Technology Data Exchange (ETDEWEB)

    BRATZEL, D.R.

    2000-09-28

    The purpose of this report is to document all software verification and validation activities, results, and findings related to the development of Resolve Version 2.5 for the analysis of flammable gas accidents in Hanford Site waste tanks.

  1. Field Verification Project for Small Wind Turbines, Quarterly Report: April - June 2001; 2nd Quarter, Issue No.5

    Energy Technology Data Exchange (ETDEWEB)

    2002-04-01

    This newsletter provides a brief overview of the Field Verification Project for Small Wind Turbines conducted out of the NWTC and a description of current activities. The newsletter also contains case studies of current projects.

  2. Field Verification Program for Small Wind Turbines: Quarterly Report for January-March 2001; 1st Quarter, Issue No.4

    Energy Technology Data Exchange (ETDEWEB)

    Forsyth, T.; Cardinal, J.

    2001-10-30

    This newsletter provides a brief overview of the Field Verification Program for Small Wind Turbines conducted out of the NWTC and a description of current activities. The newsletter also contains case studies of current projects.

  3. Field Verification Program for Small Wind Turbines: Quarterly Report for October-December 2000; 4th Quarter, Iss. No.3

    Energy Technology Data Exchange (ETDEWEB)

    Cardinal, J.

    2001-07-03

    This newsletter provides a brief overview of the Field Verification Program for Small Wind Turbines conducted out of the NWTC and a description of current activities. The newsletter also contains case studies of current projects.

  4. Field Verification Project for Small Wind Turbines Quarterly Report; July-September 2001, 3rd Quarter, Issue#6

    Energy Technology Data Exchange (ETDEWEB)

    2003-04-01

    This newsletter provides a brief overview of the Field Verification Project for Small Wind Turbines conducted at the NWTC and a description of current activities. The newsletter also contains case studies of current projects.

  5. Field Verification Program for Small Wind Turbines, Quarterly Report: 3rd Quarter, Issue No.2, July-September 2000

    Energy Technology Data Exchange (ETDEWEB)

    Cardinal. J.; Tu, P.

    2001-05-16

    This newsletter provides a brief overview of the Field Verification Program for Small Wind Turbines conducted out of the NWTC and a description of current activities. The newsletter also contains case studies of current projects.

  6. INFLUENCE OF THE THICKNESS OF JOINED ELEMENTS ON LAP LENGTH OF ALUMINIUM ALLOY SHEET BONDED JOINTS

    Directory of Open Access Journals (Sweden)

    Anna Rudawska

    2015-08-01

    Full Text Available This work features the results of experimental research in determining the limiting length of the bonded single-lap joint of materials of the same thickness, different thicknesses and of hybrid systems of different aluminium alloy sheets. The length of the bonded lap joint is just one of the structural features, critical to the strength of bonded joints, this length depending on the thickness and type of the bonded elements. In the case of single-lap bonded joints there is a limiting lap length exceeding of which should not increase the strength of such joints. This is why the length of a bonded lap joint is critical in terms of strength and application concerns. The length of the lap is not always reflected in practice due to simplification of the analytical relations. What is required is experimental verification of the derived theoretical relations. The tested materials are aluminium alloy sheets, widely used in the machinery, aviation and construction industries.

  7. Standard Verification System Lite (SVS Lite)

    Data.gov (United States)

    Social Security Administration — SVS Lite is a mainframe program used exclusively by the Office of Child Support Enforcement (OCSE) to perform batch SSN verifications. This process is exactly the...

  8. Short communication: Parentage verification of South African ...

    African Journals Online (AJOL)

    Short communication: Parentage verification of South African Angora goats, using microsatellite markers. ... South African Journal of Animal Science. Journal Home ... Eighteen markers were tested in 192 South African Angora goats representing different family structures with known and unknown parent information.

  9. Automated continuous verification for numerical simulation

    Directory of Open Access Journals (Sweden)

    P. E. Farrell

    2011-05-01

    Full Text Available Verification is a process crucially important for the final users of a computational model: code is useless if its results cannot be relied upon. Typically, verification is seen as a discrete event, performed once and for all after development is complete. However, this does not reflect the reality that many geoscientific codes undergo continuous development of the mathematical model, discretisation and software implementation. Therefore, we advocate that in such cases verification must be continuous and happen in parallel with development: the desirability of their automation follows immediately. This paper discusses a framework for automated continuous verification of wide applicability to any kind of numerical simulation. It also documents a range of test cases to show the possibilities of the framework.

  10. Tackling Verification and Validation for Prognostics

    Data.gov (United States)

    National Aeronautics and Space Administration — Verification and validation (V&V) has been identified as a critical phase in fielding systems with Integrated Systems Health Management (ISHM) solutions to...

  11. Seismic design verification of LMFBR structures

    Energy Technology Data Exchange (ETDEWEB)

    1977-07-01

    The report provides an assessment of the seismic design verification procedures currently used for nuclear power plant structures, a comparison of dynamic test methods available, and conclusions and recommendations for future LMFB structures.

  12. ENVIRONMENTAL TECHNOLOGY VERIFICATION (ETV) PROGRAM: FUEL CELLS

    Science.gov (United States)

    The U.S. Environmental Protection Agency (EPA) Environmental Technology Verification (ETV) Program evaluates the performance of innovative air, water, pollution prevention and monitoring technologies that have the potential to improve human health and the environment. This techno...

  13. Language dependence in multilingual speaker verification

    CSIR Research Space (South Africa)

    Kleynhans, NT

    2005-11-01

    Full Text Available An investigation into the performance of current speaker verification technology within a multilingual context is presented. Using the Oregon Graduate Institute (OGI) Multi-Language Telephone Speech Corpus (MLTS) database, the authors found...

  14. Data Exchanges and Verifications Online (DEVO)

    Data.gov (United States)

    Social Security Administration — DEVO is the back-end application for processing SSN verifications and data exchanges. DEVO uses modern technology for parameter driven processing of both batch and...

  15. Polarimetric and Interferometric SAR Calibration Verification Methods

    Science.gov (United States)

    Kim, Y.; Zyl, J van

    2001-01-01

    It is necessary to calibrate SAR data in order to use the data for science applications. When both polarimetric and interferometric data are collected simultaneously, these SAR data can be used for cross-calibration and verification.

  16. Procedure Verification and Validation Toolset Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed research is aimed at investigating a procedure verification and validation toolset, which will allow the engineers who are responsible for developing...

  17. Model Checking, Abstraction, and Compositional Verification

    Science.gov (United States)

    1993-07-01

    a mathematical model of the design is proved to satisfy a precise specification. Model checking is one formal verification technique. It consists of...involving the sequencing of events in time. One of the main drawbacks of model checking is the state explosion problem. This problem occurs in systems...considers two methods for avoiding the state explosion problem in the context of model checking : compositional verification and abstraction

  18. Verification and Validation in Systems Engineering

    CERN Document Server

    Debbabi, Mourad; Jarraya, Yosr; Soeanu, Andrei; Alawneh, Luay

    2010-01-01

    "Verification and validation" represents an important process used for the quality assessment of engineered systems and their compliance with the requirements established at the beginning of or during the development cycle. Debbabi and his coauthors investigate methodologies and techniques that can be employed for the automatic verification and validation of systems engineering design models expressed in standardized modeling languages. Their presentation includes a bird's eye view of the most prominent modeling languages for software and systems engineering, namely the Unified Model

  19. Transmutation Fuel Performance Code Thermal Model Verification

    Energy Technology Data Exchange (ETDEWEB)

    Gregory K. Miller; Pavel G. Medvedev

    2007-09-01

    FRAPCON fuel performance code is being modified to be able to model performance of the nuclear fuels of interest to the Global Nuclear Energy Partnership (GNEP). The present report documents the effort for verification of the FRAPCON thermal model. It was found that, with minor modifications, FRAPCON thermal model temperature calculation agrees with that of the commercial software ABAQUS (Version 6.4-4). This report outlines the methodology of the verification, code input, and calculation results.

  20. Scalable hardware verification with symbolic simulation

    CERN Document Server

    Bertacco, Valeria

    2006-01-01

    An innovative presentation of the theory of disjoint support decomposition, presenting novel results and algorithms, plus original and up-to-date techniques in formal verificationProvides an overview of current verification techniques, and unveils the inner workings of symbolic simulationFocuses on new techniques that narrow the performance gap between the complexity of digital systems and the limited ability to verify themAddresses key topics in need of future research.

  1. State of the Art in the Research of Formal Verification

    Directory of Open Access Journals (Sweden)

    Serna-M. Edgar

    2014-10-01

    Full Text Available In recent years research in formal verification of hardware and software has reached important progresses in the development of methodologies and tools to meet the increasing complexity of systems. The explicit role of Formal Verification is to find errors and to improve the reliability on the accuracy of system design, which implies a challenge for software engineering of this century. The purpose of this research is to perform a systematic review of the literature to establish the state of the art of research in formal verification during the last 10 years and to identify the approaches, methods, techniques and methodologies used, as well as the intensity of those research activities. During the process it was found that research in this field has doubled since 2005, and that the mean value of researches conducted year after year remains the same and that prevail the application in control and interaction systems. Additionally it was found that, the case study is the most used method and that empirical research is the most applied type.

  2. Verification and validation guidelines for high integrity systems. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Hecht, H.; Hecht, M.; Dinsmore, G.; Hecht, S.; Tang, D. [SoHaR, Inc., Beverly Hills, CA (United States)

    1995-03-01

    High integrity systems include all protective (safety and mitigation) systems for nuclear power plants, and also systems for which comparable reliability requirements exist in other fields, such as in the process industries, in air traffic control, and in patient monitoring and other medical systems. Verification aims at determining that each stage in the software development completely and correctly implements requirements that were established in a preceding phase, while validation determines that the overall performance of a computer system completely and correctly meets system requirements. Volume I of the report reviews existing classifications for high integrity systems and for the types of errors that may be encountered, and makes recommendations for verification and validation procedures, based on assumptions about the environment in which these procedures will be conducted. The final chapter of Volume I deals with a framework for standards in this field. Volume II contains appendices dealing with specific methodologies for system classification, for dependability evaluation, and for two software tools that can automate otherwise very labor intensive verification and validation activities.

  3. Reactive system verification case study: Fault-tolerant transputer communication

    Science.gov (United States)

    Crane, D. Francis; Hamory, Philip J.

    1993-01-01

    A reactive program is one which engages in an ongoing interaction with its environment. A system which is controlled by an embedded reactive program is called a reactive system. Examples of reactive systems are aircraft flight management systems, bank automatic teller machine (ATM) networks, airline reservation systems, and computer operating systems. Reactive systems are often naturally modeled (for logical design purposes) as a composition of autonomous processes which progress concurrently and which communicate to share information and/or to coordinate activities. Formal (i.e., mathematical) frameworks for system verification are tools used to increase the users' confidence that a system design satisfies its specification. A framework for reactive system verification includes formal languages for system modeling and for behavior specification and decision procedures and/or proof-systems for verifying that the system model satisfies the system specifications. Using the Ostroff framework for reactive system verification, an approach to achieving fault-tolerant communication between transputers was shown to be effective. The key components of the design, the decoupler processes, may be viewed as discrete-event-controllers introduced to constrain system behavior such that system specifications are satisfied. The Ostroff framework was also effective. The expressiveness of the modeling language permitted construction of a faithful model of the transputer network. The relevant specifications were readily expressed in the specification language. The set of decision procedures provided was adequate to verify the specifications of interest. The need for improved support for system behavior visualization is emphasized.

  4. Performing Verification and Validation in Reuse-Based Software Engineering

    Science.gov (United States)

    Addy, Edward A.

    1999-01-01

    The implementation of reuse-based software engineering not only introduces new activities to the software development process, such as domain analysis and domain modeling, it also impacts other aspects of software engineering. Other areas of software engineering that are affected include Configuration Management, Testing, Quality Control, and Verification and Validation (V&V). Activities in each of these areas must be adapted to address the entire domain or product line rather than a specific application system. This paper discusses changes and enhancements to the V&V process, in order to adapt V&V to reuse-based software engineering.

  5. Standard practice for verification and classification of extensometer systems

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2010-01-01

    1.1 This practice covers procedures for the verification and classification of extensometer systems, but it is not intended to be a complete purchase specification. The practice is applicable only to instruments that indicate or record values that are proportional to changes in length corresponding to either tensile or compressive strain. Extensometer systems are classified on the basis of the magnitude of their errors. 1.2 Because strain is a dimensionless quantity, this document can be used for extensometers based on either SI or US customary units of displacement. Note 1—Bonded resistance strain gauges directly bonded to a specimen cannot be calibrated or verified with the apparatus described in this practice for the verification of extensometers having definite gauge points. (See procedures as described in Test Methods E251.) 1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish app...

  6. MODEL-BASED VALIDATION AND VERIFICATION OF ANOMALIES IN LEGISLATION

    Directory of Open Access Journals (Sweden)

    Vjeran Strahonja

    2006-12-01

    Full Text Available An anomaly in legislation is absence of completeness, consistency and other desirable properties, caused by different semantic, syntactic or pragmatic reasons. In general, the detection of anomalies in legislation comprises validation and verification. The basic idea of research, as presented in this paper, is modelling legislation by capturing domain knowledge of legislation and specifying it in a generic way by using commonly agreed and understandable modelling concepts of the Unified Modelling Language (UML. Models of legislation enable to understand the system better, support the detection of anomalies and help to improve the quality of legislation by validation and verification. By implementing model-based approach, the object of validation and verification moves from legislation to its model. The business domain of legislation has two distinct aspects: a structural or static aspect (functionality, business data etc., and a behavioural or dynamic part (states, transitions, activities, sequences etc.. Because anomalism can occur on two different levels, on the level of a model, or on the level of legislation itself, a framework for validation and verification of legal regulation and its model is discussed. The presented framework includes some significant types of semantic and syntactic anomalies. Some ideas for assessment of pragmatic anomalies of models were found in the field of software quality metrics. Thus pragmatic features and attributes can be determined that could be relevant for evaluation purposes of models. Based on analogue standards for the evaluation of software, a qualitative and quantitative scale can be applied to determine the value of some feature for a specific model.

  7. Telomere Length in Elite Athletes.

    Science.gov (United States)

    Muniesa, Carlos A; Verde, Zoraida; Diaz-Ureña, Germán; Santiago, Catalina; Gutiérrez, Fernando; Díaz, Enrique; Gómez-Gallego, Félix; Pareja-Galeano, Helios; Soares-Miranda, Luisa; Lucia, Alejandro

    2017-08-01

    Growing evidence suggests that regular moderate-intensity physical activity is associated with an attenuation of leukocyte telomere length (LTL) shortening. However, more controversy exists regarding higher exercise loads such as those imposed by elite-sport participation. The authors investigated LTL differences between young elite athletes (n = 61, 54% men, age [mean ± SD] 27.2 ± 4.9 y) and healthy nonsmoker, physically inactive controls (n = 64, 52% men, 28.9 ± 6.3 y) using analysis of variance (ANOVA). Elite athletes had, on average, higher LTL than control subjects, 0.89 ± 0.26 vs 0.78 ± 0.31, P = .013 for the group effect, with no significant sex (P = .995) or age effect (P = .114). The results suggest that young elite athletes have longer telomeres than their inactive peers. Further research might assess the LTL of elite athletes of varying ages compared with both age-matched active and inactive individuals.

  8. Context-aware approach for formal verification

    Directory of Open Access Journals (Sweden)

    Amel Benabbou

    2016-02-01

    Full Text Available The Context-aware approach has proven to be an effective technique for software model-checking verification. It focuses on the explicit modelling of environment as one or more contexts. In this area, specifying precise requirement is a challenged task for engineer since often environmental conditions lack of precision. A DSL, called CDL, has been proposed to facilitate the specification of requirement and context. However, such language is still low-level and error prone, difficult to grasp on complex models and assessment about its usability is still mitigated. In this paper, we propose a high level formalism of CDL to facilitate specifying contexts based on interaction overview diagrams that orchestrate activity diagrams automatically transformed from textual use cases. Our approach highlights the boundaries between the system and its environment. It is qualified as model checking context-aware that aims to reduce the semantic gap between informal and formal requirements, hence the objective is to assist and encourage engineers to put sufficient details to accomplish effectively the specification process.

  9. Field verification of CO sub 2 -foam

    Energy Technology Data Exchange (ETDEWEB)

    Martin, F.D.; Heller, J.P.; Weiss, W.W.

    1992-05-01

    In September 1989, the Petroleum Recovery Research Center (PRRC), a division of New Mexico Institute of Mining and Technology, received a grant from the US Department of Energy (DOE) for a project entitled Field Verification of CO{sub 2} Foam.'' The grant provided for an extension of the PRRC laboratory work to a field testing stage to be performed in collaboration with an oil producer actively conducting a CO{sub 2} flood. The objectives of this project are to: (1) conduct reservoir studies, laboratory tests, simulation runs, and field tests to evaluate the use of foam for mobility control or fluid diversion in a New Mexico CO{sub 2} flood, and (2) evaluate the concept of CO{sub 2}-foam in the field by using a reservoir where CO{sub 2} flooding is ongoing, characterizing the reservoir, modeling the process, and monitoring performance of the field test. Seven tasks were identified for the successful completion of the project: (1) evaluate and select a field site, (2) develop an initial site- specific plan, (3) conduct laboratory CO{sub 2}-foam mobility tests, (4) perform reservoir simulations, (5) design the foam slug, (6) implement a field test, and (7) evaluate results.

  10. STAR-CCM+ Verification and Validation Plan

    Energy Technology Data Exchange (ETDEWEB)

    Pointer, William David [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-09-30

    The commercial Computational Fluid Dynamics (CFD) code STAR-CCM+ provides general purpose finite volume method solutions for fluid dynamics and energy transport. This document defines plans for verification and validation (V&V) of the base code and models implemented within the code by the Consortium for Advanced Simulation of Light water reactors (CASL). The software quality assurance activities described herein are port of the overall software life cycle defined in the CASL Software Quality Assurance (SQA) Plan [Sieger, 2015]. STAR-CCM+ serves as the principal foundation for development of an advanced predictive multi-phase boiling simulation capability within CASL. The CASL Thermal Hydraulics Methods (THM) team develops advanced closure models required to describe the subgrid-resolution behavior of secondary fluids or fluid phases in multiphase boiling flows within the Eulerian-Eulerian framework of the code. These include wall heat partitioning models that describe the formation of vapor on the surface and the forces the define bubble/droplet dynamic motion. The CASL models are implemented as user coding or field functions within the general framework of the code. This report defines procedures and requirements for V&V of the multi-phase CFD capability developed by CASL THM. Results of V&V evaluations will be documented in a separate STAR-CCM+ V&V assessment report. This report is expected to be a living document and will be updated as additional validation cases are identified and adopted as part of the CASL THM V&V suite.

  11. INNOVATIVE TECHNOLOGY VERIFICATION REPORT XRF ...

    Science.gov (United States)

    The Niton XLt 700 Series (XLt) XRF Services x-ray fluorescence (XRF) analyzer was demonstrated under the U.S. Environmental Protection Agency (EPA) Superfund Innovative Technology Evaluation (SITE) Program. The field portion of the demonstration was conducted in January 2005 at the Kennedy Athletic, Recreational and Social Park (KARS) at Kennedy Space Center on Merritt Island, Florida. The demonstration was designed to collect reliable performance and cost data for the XLt analyzer and seven other commercially available XRF instruments for measuring trace elements in soil and sediment. The performance and cost data were evaluated to document the relative performance of each XRF instrument. This innovative technology verification report describes the objectives and the results of that evaluation and serves to verify the performance and cost of the XLt analyzer. Separate reports have been prepared for the other XRF instruments that were evaluated as part of the demonstration. The objectives of the evaluation included determining each XRF instrument’s accuracy, precision, sample throughput, and tendency for matrix effects. To fulfill these objectives, the field demonstration incorporated the analysis of 326 prepared samples of soil and sediment that contained 13 target elements. The prepared samples included blends of environmental samples from nine different sample collection sites as well as spiked samples with certified element concentrations. Accuracy

  12. Visual inspection for CTBT verification

    Energy Technology Data Exchange (ETDEWEB)

    Hawkins, W.; Wohletz, K.

    1997-03-01

    On-site visual inspection will play an essential role in future Comprehensive Test Ban Treaty (CTBT) verification. Although seismic and remote sensing techniques are the best understood and most developed methods for detection of evasive testing of nuclear weapons, visual inspection can greatly augment the certainty and detail of understanding provided by these more traditional methods. Not only can visual inspection offer ``ground truth`` in cases of suspected nuclear testing, but it also can provide accurate source location and testing media properties necessary for detailed analysis of seismic records. For testing in violation of the CTBT, an offending party may attempt to conceal the test, which most likely will be achieved by underground burial. While such concealment may not prevent seismic detection, evidence of test deployment, location, and yield can be disguised. In this light, if a suspicious event is detected by seismic or other remote methods, visual inspection of the event area is necessary to document any evidence that might support a claim of nuclear testing and provide data needed to further interpret seismic records and guide further investigations. However, the methods for visual inspection are not widely known nor appreciated, and experience is presently limited. Visual inspection can be achieved by simple, non-intrusive means, primarily geological in nature, and it is the purpose of this report to describe the considerations, procedures, and equipment required to field such an inspection.

  13. Monitoring and verification R&D

    Energy Technology Data Exchange (ETDEWEB)

    Pilat, Joseph F [Los Alamos National Laboratory; Budlong - Sylvester, Kory W [Los Alamos National Laboratory; Fearey, Bryan L [Los Alamos National Laboratory

    2011-01-01

    The 2010 Nuclear Posture Review (NPR) report outlined the Administration's approach to promoting the agenda put forward by President Obama in Prague on April 5, 2009. The NPR calls for a national monitoring and verification R&D program to meet future challenges arising from the Administration's nonproliferation, arms control and disarmament agenda. Verification of a follow-on to New START could have to address warheads and possibly components along with delivery capabilities. Deeper cuts and disarmament would need to address all of these elements along with nuclear weapon testing, nuclear material and weapon production facilities, virtual capabilities from old weapon and existing energy programs and undeclared capabilities. We only know how to address some elements of these challenges today, and the requirements may be more rigorous in the context of deeper cuts as well as disarmament. Moreover, there is a critical need for multiple options to sensitive problems and to address other challenges. There will be other verification challenges in a world of deeper cuts and disarmament, some of which we are already facing. At some point, if the reductions process is progressing, uncertainties about past nuclear materials and weapons production will have to be addressed. IAEA safeguards will need to continue to evolve to meet current and future challenges, and to take advantage of new technologies and approaches. Transparency/verification of nuclear and dual-use exports will also have to be addressed, and there will be a need to make nonproliferation measures more watertight and transparent. In this context, and recognizing we will face all of these challenges even if disarmament is not achieved, this paper will explore possible agreements and arrangements; verification challenges; gaps in monitoring and verification technologies and approaches; and the R&D required to address these gaps and other monitoring and verification challenges.

  14. Zinc sulfate contributes to promote telomere length extension via increasing telomerase gene expression, telomerase activity and change in the TERT gene promoter CpG island methylation status of human adipose-derived mesenchymal stem cells.

    Directory of Open Access Journals (Sweden)

    Raheleh Farahzadi

    Full Text Available The use of mesenchymal stem cells (MSCs for cell therapy and regenerative medicine has received widespread attention over the past few years, but their application can be complicated by factors such as reduction in proliferation potential, the senescent tendency of the MSCs upon expansion and their age-dependent decline in number and function. It was shown that all the mentioned features were accompanied by a reduction in telomerase activity and telomere shortening. Furthermore, the role of epigenetic changes in aging, especially changes in promoter methylation, was reported. In this study, MSCs were isolated from the adipose tissue with enzymatic digestion. In addition, immunocytochemistry staining and flow cytometric analysis were performed to investigate the cell-surface markers. In addition, alizarin red-S, sudan III, toluidine blue, and cresyl violet staining were performed to evaluate the multi-lineage differentiation of hADSCs. In order to improve the effective application of MSCs, these cells were treated with 1.5 × 10-8 and 2.99 × 10-10 M of ZnSO4 for 48 hours. The length of the absolute telomere, human telomerase reverse transcriptase (hTERT gene expression, telomerase activity, the investigation of methylation status of the hTERT gene promoter and the percentage of senescent cells were analyzed with quantitative real-time PCR, PCR-ELISA TRAP assay, methylation specific PCR (MSP, and beta-galactosidase (SA-β-gal staining, respectively. The results showed that the telomere length, the hTERT gene expression, and the telomerase activity had significantly increased. In addition, the percentage of senescent cells had significantly decreased and changes in the methylation status of the CpG islands in the hTERT promoter region under treatment with ZnSO4 were seen. In conclusion, it seems that ZnSO4 as a proper antioxidant could improve the aging-related features due to lengthening of the telomeres, increasing the telomerase gene expression

  15. Java bytecode verification via static single assignment form

    DEFF Research Database (Denmark)

    Gal, Andreas; Probst, Christian W.; Franz, Michael

    2008-01-01

    Java Virtual Machines (JVMs) traditionally perform bytecode verification by way of an iterative data-flow analysis. Bytecode verification is necessary to ensure type safety because temporary variables in the JVM are not statically typed. We present an alternative verification mechanism that trans......Java Virtual Machines (JVMs) traditionally perform bytecode verification by way of an iterative data-flow analysis. Bytecode verification is necessary to ensure type safety because temporary variables in the JVM are not statically typed. We present an alternative verification mechanism...... the additional benefit of generating SSA as a side effect, which may be immediately useful for a subsequent dynamic compilation stage....

  16. Specified gas emitters regulation : offset credit verification guidance document

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-09-15

    In response to concerns about global warming, the Alberta Government has committed to taking effective action on climate change. One of actions was the development of a carbon compliance system which allows emission offsets as a compliance option. As of July 2007, Alberta's regulatory system for managing greenhouse gases has enabled a compliance-based carbon market to develop in the province. However, in order to be effective, the compliance-based carbon market must reflect Alberta's environmental and economic circumstances, and must also demonstrate consistency with national efforts to reduce climate change. Regulated firms in Alberta can now buy verified emission reductions or removal of greenhouse gases from voluntary actions arising from unregulated activities in the province. This market-based approach offers flexibility for emitters, since markets generally determine the most cost-effective emission reduction opportunities. In addition, the ability to sell offsets provides an incentive to innovate and invest in activities that will reduce greenhouse gas emissions beyond regulated activities. Since this approach is new, this guidance document was prepared to help buyers and sellers regarding their investments. In particular, it outlined the process requirements for undertaking offset projects in Alberta. Verification is a mandatory requirement for Alberta-based offsets that will be used for compliance purposes under the Alberta Regulation. This guide explained how to prepare for, and what to expect during verification. The offset verification process ensures that Alberta Environment receives emission offsets in compliance reports which are credible and of sufficient quality to use as a compliance option under the system. 2 tabs., 3 figs., 4 appendices.

  17. An integrated user-oriented laboratory for verification of digital flight control systems: Features and capabilities

    Science.gov (United States)

    Defeo, P.; Doane, D.; Saito, J.

    1982-01-01

    A Digital Flight Control Systems Verification Laboratory (DFCSVL) has been established at NASA Ames Research Center. This report describes the major elements of the laboratory, the research activities that can be supported in the area of verification and validation of digital flight control systems (DFCS), and the operating scenarios within which these activities can be carried out. The DFCSVL consists of a palletized dual-dual flight-control system linked to a dedicated PDP-11/60 processor. Major software support programs are hosted in a remotely located UNIVAC 1100 accessible from the PDP-11/60 through a modem link. Important features of the DFCSVL include extensive hardware and software fault insertion capabilities, a real-time closed loop environment to exercise the DFCS, an integrated set of software verification tools, and a user-oriented interface to all the resources and capabilities.

  18. Comparison of intensities and rest periods for VO2max verification testing procedures.

    Science.gov (United States)

    Nolan, P B; Beaven, M L; Dalleck, L

    2014-11-01

    We sought to determine the incidence of 'true' VO2max confirmation with the verification procedure across different protocols. 12 active participants (men n=6, women n=6) performed in random order 4 different maximal graded exercises tests (GXT) and verification bout protocols on 4 separate days. Conditions for the rest period and verification bout intensity were: A - 105% intensity, 20 min rest; B - 105% intensity, 60 min rest; C - 115% intensity, 20 min rest; D - 115% intensity, 60 min rest. VO2max confirmation (difference between peak VO2 GXT and verification trialVO2max confirmation across all exercise test conditions (intensity effect within recovery 20 min (χ(2) (1)=4.800, pVO2max confirmation with different rest periods. We recommend the use of 105% of the maximal GXT workload and 20 min rest periods when using verification trials to confirm VO2max in normally active populations. © Georg Thieme Verlag KG Stuttgart · New York.

  19. Fibre operating lengths of human lower limb muscles during walking.

    Science.gov (United States)

    Arnold, Edith M; Delp, Scott L

    2011-05-27

    Muscles actuate movement by generating forces. The forces generated by muscles are highly dependent on their fibre lengths, yet it is difficult to measure the lengths over which muscle fibres operate during movement. We combined experimental measurements of joint angles and muscle activation patterns during walking with a musculoskeletal model that captures the relationships between muscle fibre lengths, joint angles and muscle activations for muscles of the lower limb. We used this musculoskeletal model to produce a simulation of muscle-tendon dynamics during walking and calculated fibre operating lengths (i.e. the length of muscle fibres relative to their optimal fibre length) for 17 lower limb muscles. Our results indicate that when musculotendon compliance is low, the muscle fibre operating length is determined predominantly by the joint angles and muscle moment arms. If musculotendon compliance is high, muscle fibre operating length is more dependent on activation level and force-length-velocity effects. We found that muscles operate on multiple limbs of the force-length curve (i.e. ascending, plateau and descending limbs) during the gait cycle, but are active within a smaller portion of their total operating range.

  20. High-level Synthesis Integrated Verification

    Directory of Open Access Journals (Sweden)

    M. Dossis

    2015-10-01

    Full Text Available It is widely known in the engineering community that more than 60% of the IC design project time is spent on verification. For the very complex contemporary chips, this may prove prohibitive for the IC to arrive at the correct time in the market and therefore, valuable sales share may be lost by the developing industry. This problem is deteriorated by the fact that most of conventional verification flows are highly repetitive and a great proportion of the project time is spent on last-moment simulations. In this paper we present an integrated approach to rapid, high-level verification, exploiting the advantages of a formal High-level Synthesis tool, developed by the author. Verification in this work is supported at 3 levels: high-level program code, RTL simulation and rapid, generated C testbench execution. This paper is supported by strong experimental work with 3-4 popular design synthesis and verification that proves the principles of our methodology.

  1. Cleanup Verification Package for the 116-K-2 Effluent Trench

    Energy Technology Data Exchange (ETDEWEB)

    J. M. Capron

    2006-04-04

    This cleanup verification package documents completion of remedial action for the 116-K-2 effluent trench, also referred to as the 116-K-2 mile-long trench and the 116-K-2 site. During its period of operation, the 116-K-2 site was used to dispose of cooling water effluent from the 105-KE and 105-KW Reactors by percolation into the soil. This site also received mixed liquid wastes from the 105-KW and 105-KE fuel storage basins, reactor floor drains, and miscellaneous decontamination activities.

  2. Simulator Semantics for System Level Formal Verification

    Directory of Open Access Journals (Sweden)

    Toni Mancini

    2015-09-01

    Full Text Available Many simulation based Bounded Model Checking approaches to System Level Formal Verification (SLFV have been devised. Typically such approaches exploit the capability of simulators to save computation time by saving and restoring the state of the system under simulation. However, even though such approaches aim to (bounded formal verification, as a matter of fact, the simulator behaviour is not formally modelled and the proof of correctness of the proposed approaches basically relies on the intuitive notion of simulator behaviour. This gap makes it hard to check if the optimisations introduced to speed up the simulation do not actually omit checking relevant behaviours of the system under verification. The aim of this paper is to fill the above gap by presenting a formal semantics for simulators.

  3. PECULIARITIES OF MORPHOLOGICAL VERIFICATION IN BREAST CANCER

    Directory of Open Access Journals (Sweden)

    L.F. Zhandarova

    2008-06-01

    Full Text Available 80 case histories of patients with breast cancer were analyzed. During the preoperative examination with objective and instrumental examination methods used the malignant process was suspected but no morphological verification was received. Physical examination revealed 75% cases of cancer. Roentgenologic evidence of malignant tumor was found in 43.5% women. Ultrasound examination of mammary glands showed that 57.7% of patients had cancer symptoms. Despite the repeated puncture aspiration biopsy, preoperative morphological examination proved to be negative. The reasons of morphological verification failure are connected with technical difficulties and morphological features of tumor structure. Negative malignant process verification necessitated the diagnostic partial mastectomy. To achieve ablasticity ofexcisional biopsyit is necessary to keep 2 cm from the tumor. Staged morphological diagnosis verifies the diagnosis in all patients, allowing to choose the adequate extentof surgical procedures.

  4. Constraint Specialisation in Horn Clause Verification

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick

    2015-01-01

    We present a method for specialising the constraints in constrained Horn clauses with respect to a goal. We use abstract interpretation to compute a model of a query-answer transformation of a given set of clauses and a goal. The effect is to propagate the constraints from the goal top-down and p......We present a method for specialising the constraints in constrained Horn clauses with respect to a goal. We use abstract interpretation to compute a model of a query-answer transformation of a given set of clauses and a goal. The effect is to propagate the constraints from the goal top...... results on verification problems show that this is an effective transformation, both in our own verification tools (convex polyhedra analyser) and as a pre-processor to other Horn clause verification tools....

  5. Constraint specialisation in Horn clause verification

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick

    2017-01-01

    We present a method for specialising the constraints in constrained Horn clauses with respect to a goal. We use abstract interpretation to compute a model of a query–answer transformed version of a given set of clauses and a goal. The constraints from the model are then used to compute a speciali......We present a method for specialising the constraints in constrained Horn clauses with respect to a goal. We use abstract interpretation to compute a model of a query–answer transformed version of a given set of clauses and a goal. The constraints from the model are then used to compute...... underlying the clauses. Experimental results on verification problems show that this is an effective transformation, both in our own verification tools (based on a convex polyhedra analyser) and as a pre-processor to other Horn clause verification tools....

  6. Software Verification of Orion Cockpit Displays

    Science.gov (United States)

    Biswas, M. A. Rafe; Garcia, Samuel; Prado, Matthew; Hossain, Sadad; Souris, Matthew; Morin, Lee

    2017-01-01

    NASA's latest spacecraft Orion is in the development process of taking humans deeper into space. Orion is equipped with three main displays to monitor and control the spacecraft. To ensure the software behind the glass displays operates without faults, rigorous testing is needed. To conduct such testing, the Rapid Prototyping Lab at NASA's Johnson Space Center along with the University of Texas at Tyler employed a software verification tool, EggPlant Functional by TestPlant. It is an image based test automation tool that allows users to create scripts to verify the functionality within a program. A set of edge key framework and Common EggPlant Functions were developed to enable creation of scripts in an efficient fashion. This framework standardized the way to code and to simulate user inputs in the verification process. Moreover, the Common EggPlant Functions can be used repeatedly in verification of different displays.

  7. Length-weight and length-length relationships for six fish species from Zohreh River, Iran

    Directory of Open Access Journals (Sweden)

    Yazdan Keivany

    2017-01-01

    Full Text Available The present study reports Length-weight and length-length parameters for six fish species belonging to four families from the Zohreh River. The weight-length relationships were estimated using the equation W= Lb. The values of the slope parameter (b varied between 2.72 and 3.72, with a mean±SD of 3.015±0.18. The values b parameter in the length-weight relationship equations were calculated as 2.72 for Arabibarbus grypus (Heckel, 1843, 2.96 for Capoeta trutta (Heckel, 1843, 2.72 for Garra rufa (Heckel, 1843, 3.25 for Aphanius dispar (Rüppell, 1829, 2.91 for Sillago sihama (Forsskål, 1775 and 3.15 for Glyptothorax silviae Coad, 1981. This study presents the first reference on LWR and LLR for these species in Zohreh River.

  8. Specification and Automated Verification of Real-Time Behaviour

    DEFF Research Database (Denmark)

    Andersen, J.H.; Kristensen, C.H.; Skou, A.

    1996-01-01

    In this paper we sketch a method for specification and automatic verification of real-time software properties.......In this paper we sketch a method for specification and automatic verification of real-time software properties....

  9. Specification and Automated Verification of Real-Time Behaviour

    DEFF Research Database (Denmark)

    Kristensen, C.H.; Andersen, J.H.; Skou, A.

    1995-01-01

    In this paper we sketch a method for specification and automatic verification of real-time software properties.......In this paper we sketch a method for specification and automatic verification of real-time software properties....

  10. Verification and quality control of routine hematology analyzers

    NARCIS (Netherlands)

    Vis, J Y; Huisman, A|info:eu-repo/dai/nl/255170653

    Verification of hematology analyzers (automated blood cell counters) is mandatory before new hematology analyzers may be used in routine clinical care. The verification process consists of several items which comprise among others: precision, accuracy, comparability, carryover, background and

  11. Numerical Weather Predictions Evaluation Using Spatial Verification Methods

    Science.gov (United States)

    Tegoulias, I.; Pytharoulis, I.; Kotsopoulos, S.; Kartsios, S.; Bampzelis, D.; Karacostas, T.

    2014-12-01

    During the last years high-resolution numerical weather prediction simulations have been used to examine meteorological events with increased convective activity. Traditional verification methods do not provide the desired level of information to evaluate those high-resolution simulations. To assess those limitations new spatial verification methods have been proposed. In the present study an attempt is made to estimate the ability of the WRF model (WRF -ARW ver3.5.1) to reproduce selected days with high convective activity during the year 2010 using those feature-based verification methods. Three model domains, covering Europe, the Mediterranean Sea and northern Africa (d01), the wider area of Greece (d02) and central Greece - Thessaly region (d03) are used at horizontal grid-spacings of 15km, 5km and 1km respectively. By alternating microphysics (Ferrier, WSM6, Goddard), boundary layer (YSU, MYJ) and cumulus convection (Kain-­-Fritsch, BMJ) schemes, a set of twelve model setups is obtained. The results of those simulations are evaluated against data obtained using a C-Band (5cm) radar located at the centre of the innermost domain. Spatial characteristics are well captured but with a variable time lag between simulation results and radar data. Acknowledgements: This research is co­financed by the European Union (European Regional Development Fund) and Greek national funds, through the action "COOPERATION 2011: Partnerships of Production and Research Institutions in Focused Research and Technology Sectors" (contract number 11SYN_8_1088 - DAPHNE) in the framework of the operational programme "Competitiveness and Entrepreneurship" and Regions in Transition (OPC II, NSRF 2007-­-2013).

  12. Exploring implementation practices in results-based financing: the case of the verification in Benin.

    Science.gov (United States)

    Antony, Matthieu; Bertone, Maria Paola; Barthes, Olivier

    2017-03-14

    Results-based financing (RBF) has been introduced in many countries across Africa and a growing literature is building around the assessment of their impact. These studies are usually quantitative and often silent on the paths and processes through which results are achieved and on the wider health system effects of RBF. To address this gap, our study aims at exploring the implementation of an RBF pilot in Benin, focusing on the verification of results. The study is based on action research carried out by authors involved in the pilot as part of the agency supporting the RBF implementation in Benin. While our participant observation and operational collaboration with project's stakeholders informed the study, the analysis is mostly based on quantitative and qualitative secondary data, collected throughout the project's implementation and documentation processes. Data include project documents, reports and budgets, RBF data on service outputs and on the outcome of the verification, daily activity timesheets of the technical assistants in the districts, as well as focus groups with Community-based Organizations and informal interviews with technical assistants and district medical officers. Our analysis focuses on the actual practices of quantitative, qualitative and community verification. Results show that the verification processes are complex, costly and time-consuming, and in practice they end up differing from what designed originally. We explore the consequences of this on the operation of the scheme, on its potential to generate the envisaged change. We find, for example, that the time taken up by verification procedures limits the time available for data analysis and feedback to facility staff, thus limiting the potential to improve service delivery. Verification challenges also result in delays in bonus payment, which delink effort and reward. Additionally, the limited integration of the verification activities of district teams with their routine tasks

  13. The formal verification of generic interpreters

    Science.gov (United States)

    Windley, P.; Levitt, K.; Cohen, G. C.

    1991-01-01

    The task assignment 3 of the design and validation of digital flight control systems suitable for fly-by-wire applications is studied. Task 3 is associated with formal verification of embedded systems. In particular, results are presented that provide a methodological approach to microprocessor verification. A hierarchical decomposition strategy for specifying microprocessors is also presented. A theory of generic interpreters is presented that can be used to model microprocessor behavior. The generic interpreter theory abstracts away the details of instruction functionality, leaving a general model of what an interpreter does.

  14. On Backward-Style Anonymity Verification

    Science.gov (United States)

    Kawabe, Yoshinobu; Mano, Ken; Sakurada, Hideki; Tsukada, Yasuyuki

    Many Internet services and protocols should guarantee anonymity; for example, an electronic voting system should guarantee to prevent the disclosure of who voted for which candidate. To prove trace anonymity, which is an extension of the formulation of anonymity by Schneider and Sidiropoulos, this paper presents an inductive method based on backward anonymous simulations. We show that the existence of an image-finite backward anonymous simulation implies trace anonymity. We also demonstrate the anonymity verification of an e-voting protocol (the FOO protocol) with our backward anonymous simulation technique. When proving the trace anonymity, this paper employs a computer-assisted verification tool based on a theorem prover.

  15. Time Optimal Reachability Analysis Using Swarm Verification

    DEFF Research Database (Denmark)

    Zhang, Zhengkui; Nielsen, Brian; Larsen, Kim Guldstrand

    2016-01-01

    and planning problems, response time optimization etc. We propose swarm verification to accelerate time optimal reachability using the real-time model-checker Uppaal. In swarm verification, a large number of model checker instances execute in parallel on a computer cluster using different, typically randomized...... search strategies. We develop four swarm algorithms and evaluate them with four models in terms scalability, and time- and memory consumption. Three of these cooperate by exchanging costs of intermediate solutions to prune the search using a branch-and-bound approach. Our results show that swarm...

  16. Towards Verification and Validation for Increased Autonomy

    Science.gov (United States)

    Giannakopoulou, Dimitra

    2017-01-01

    This presentation goes over the work we have performed over the last few years on verification and validation of the next generation onboard collision avoidance system, ACAS X, for commercial aircraft. It describes our work on probabilistic verification and synthesis of the model that ACAS X is based on, and goes on to the validation of that model with respect to actual simulation and flight data. The presentation then moves on to identify the characteristics of ACAS X that are related to autonomy and to discuss the challenges that autonomy pauses on VV. All work presented has already been published.

  17. Structural verification of an aged composite reflector

    Science.gov (United States)

    Lou, Michael C.; Tsuha, Walter S.

    1991-01-01

    A structural verification program applied to qualifying two heritage composite antenna reflectors for flight on the TOPEX satellite is outlined. The verification requirements and an integrated analyses/test approach employed to meet these requirements are described. Structural analysis results and qualification vibration test data are presented and discussed. It was determined that degradation of the composite and bonding materials caused by long-term exposure to an uncontrolled environment had not severely impaired the integrity of the reflector structures. The reflectors were assessed to be structurally adequate for the intended TOPEX application.

  18. Hybrid Enrichment Verification Array: Module Characterization Studies

    Energy Technology Data Exchange (ETDEWEB)

    Zalavadia, Mital A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Smith, Leon E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); McDonald, Benjamin S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Kulisek, Jonathan A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Mace, Emily K. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Deshmukh, Nikhil S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-03-01

    The work presented in this report is focused on the characterization and refinement of the Hybrid Enrichment Verification Array (HEVA) approach, which combines the traditional 186-keV 235U signature with high-energy prompt gamma rays from neutron capture in the detector and surrounding collimator material, to determine the relative enrichment and 235U mass of the cylinder. The design of the HEVA modules (hardware and software) deployed in the current field trial builds on over seven years of study and evolution by PNNL, and consists of a ø3''×3'' NaI(Tl) scintillator coupled to an Osprey digital multi-channel analyzer tube base from Canberra. The core of the HEVA methodology, the high-energy prompt gamma-ray signature, serves as an indirect method for the measurement of total neutron emission from the cylinder. A method for measuring the intrinsic efficiency of this “non-traditional” neutron signature and the results from a benchmark experiment are presented. Also discussed are potential perturbing effects on the non-traditional signature, including short-lived activation of materials in the HEVA module. Modeling and empirical results are presented to demonstrate that such effects are expected to be negligible for the envisioned implementation scenario. In comparison to previous versions, the new design boosts the high-energy prompt gamma-ray signature, provides more flexible and effective collimation, and improves count-rate management via commercially available pulse-processing electronics with a special modification prompted by PNNL.

  19. Alignment Verification in the Early Stage of Service Design

    OpenAIRE

    Tapandjieva, Gorica; Filipponi, Matteo; Wegmann, Alain

    2017-01-01

    Verification is a costly task, sometimes burdensome and tedious, requiring strong formal background. To reduce the effort and cost invested in verification, we developed a model-driven approach for automatic verification of service properties, done in the early service design phase. Our approach is based on SEAM, a service modeling method, and it incorporates a verification system called Leon. With our approach service designers do not need substantial understanding of specific formal and ver...

  20. Three-step method for menstrual and oral contraceptive cycle verification.

    Science.gov (United States)

    Schaumberg, Mia A; Jenkins, David G; Janse de Jonge, Xanne A K; Emmerton, Lynne M; Skinner, Tina L

    2017-11-01

    Fluctuating endogenous and exogenous ovarian hormones may influence exercise parameters; yet control and verification of ovarian hormone status is rarely reported and limits current exercise science and sports medicine research. The purpose of this study was to determine the effectiveness of an individualised three-step method in identifying the mid-luteal or high hormone phase in endogenous and exogenous hormone cycles in recreationally-active women and determine hormone and demographic characteristics associated with unsuccessful classification. Cross-sectional study design. Fifty-four recreationally-active women who were either long-term oral contraceptive users (n=28) or experiencing regular natural menstrual cycles (n=26) completed step-wise menstrual mapping, urinary ovulation prediction testing and venous blood sampling for serum/plasma hormone analysis on two days, 6-12days after positive ovulation prediction to verify ovarian hormone concentrations. Mid-luteal phase was successfully verified in 100% of oral contraceptive users, and 70% of naturally-menstruating women. Thirty percent of participants were classified as luteal phase deficient; when excluded, the success of the method was 89%. Lower age, body fat and longer menstrual cycles were significantly associated with luteal phase deficiency. A step-wise method including menstrual cycle mapping, urinary ovulation prediction and serum/plasma hormone measurement was effective at verifying ovarian hormone status. Additional consideration of age, body fat and cycle length enhanced identification of luteal phase deficiency in physically-active women. These findings enable the development of stricter exclusion criteria for female participants in research studies and minimise the influence of ovarian hormone variations within sports and exercise science and medicine research. Copyright © 2016 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  1. Fast, simple, and informative patient-specific dose verification method for intensity modulated total marrow irradiation with helical tomotherapy.

    Science.gov (United States)

    Takahashi, Yutaka; Hui, Susanta K

    2014-01-25

    Patient-specific dose verification for treatment planning in helical tomotherapy is routinely performed using a homogeneous virtual water cylindrical phantom of 30 cm diameter and 18 cm length (Cheese phantom). Because of this small length, treatment with total marrow irradiation (TMI) requires multiple deliveries of the dose verification procedures to cover a wide range of the target volumes, which significantly prolongs the dose verification process. We propose a fast, simple, and informative patient-specific dose verification method which reduce dose verification time for TMI with helical tomotherapy. We constructed a two-step solid water slab phantom (length 110 cm, height 8 cm, and two-step width of 30 cm and 15 cm), termed the Whole Body Phantom (WB phantom). Three ionization chambers and three EDR-2 films can be inserted to cover extended field TMI treatment delivery. Three TMI treatment plans were conducted with a TomoTherapy HiArt Planning Station and verified using the WB phantom with ion chambers and films. Three regions simulating the head and neck, thorax, and pelvis were covered in a single treatment delivery. The results were compared to those with the cheese phantom supplied by Accuray, Inc. following three treatment deliveries to cover the body from head to pelvis. Use of the WB phantom provided point doses or dose distributions from head and neck to femur in a single treatment delivery of TMI. Patient-specific dose verification with the WB phantom was 62% faster than with the cheese phantom. The average pass rate in gamma analysis with the criteria of a 3-mm distance-to-agreement and 3% dose differences was 94% ± 2% for the three TMI treatment plans. The differences in pass rates between the WB and cheese phantoms at the upper thorax to abdomen regions were within 2%. The calculated dose agreed with the measured dose within 3% for all points in all five cases in both the WB and cheese phantoms. Our dose verification method with the WB phantom

  2. 30 CFR 50.41 - Verification of reports.

    Science.gov (United States)

    2010-07-01

    ..., INJURIES, ILLNESSES, EMPLOYMENT, AND COAL PRODUCTION IN MINES Maintenance of Records; Verification of Information § 50.41 Verification of reports. Upon request by MSHA, an operator shall allow MSHA to inspect and... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Verification of reports. 50.41 Section 50.41...

  3. 19 CFR 351.307 - Verification of information.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Verification of information. 351.307 Section 351... COUNTERVAILING DUTIES Information and Argument § 351.307 Verification of information. (a) Introduction. Prior to... verify relevant factual information. This section clarifies when verification will occur, the contents of...

  4. 7 CFR 1260.550 - Verification of information.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Verification of information. 1260.550 Section 1260... Cattlemen's Beef Promotion and Research Board § 1260.550 Verification of information. The Secretary may require verification of the information to determine eligibility for certification to make nominations...

  5. The Construction of Verification Models for Embedded Systems

    NARCIS (Netherlands)

    Mader, Angelika H.; Wupper, H.; Boon, Mieke

    2007-01-01

    The usefulness of verification hinges on the quality of the verification model. Verification is useful if it increases our confidence that an artefact bahaves as expected. As modelling inherently contains non-formal elements, the qualityof models cannot be captured by purely formal means. Still, we

  6. 34 CFR 668.54 - Selection of applications for verification.

    Science.gov (United States)

    2010-07-01

    ... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION STUDENT ASSISTANCE GENERAL PROVISIONS Verification of Student Aid Application Information § 668.54 Selection of applications for verification. (a) General... 34 Education 3 2010-07-01 2010-07-01 false Selection of applications for verification. 668.54...

  7. Automated Verification of Mesoscale Forecasts using Image Processing Techniques

    Science.gov (United States)

    2005-09-30

    human-machine interaction, and model and forecast verification with an emphasis on mesoscale ensembles and visualization of uncertainty . The... uncertainty . The verification effort?s long-term goal is to develop an automated, objective verification technique for assessment of very high-resolution...into the MVT framework. These include agglomerative cluster analysis (Marzban and Sandgathe, 2005) and variograms . WORK COMPLETED FY2003

  8. 24 CFR 5.512 - Verification of eligible immigration status.

    Science.gov (United States)

    2010-04-01

    ... immigration status. 5.512 Section 5.512 Housing and Urban Development Office of the Secretary, Department of... Noncitizens § 5.512 Verification of eligible immigration status. (a) General. Except as described in paragraph...) Primary verification—(1) Automated verification system. Primary verification of the immigration status of...

  9. Multi-Modal Human Verification Using Face and Speech

    OpenAIRE

    Park, Changhan; Paik, Joonki

    2007-01-01

    In this chapter, we present a human verification method using combined face and speech information in order to improve the problem of single biometric verification. Single biometric verification has the fundamental problems of high FAR and FRR. So we present a

  10. 19 CFR 181.72 - Verification scope and method.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Verification scope and method. 181.72 Section 181... THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Origin Verifications and Determinations § 181.72 Verification scope and method. (a) General. Subject to paragraph (e) of this section, Customs...

  11. Verification of automata-based programs (supervised by Anatoly Shalyto)

    OpenAIRE

    Evgeny, Kurbatsky

    2008-01-01

    This paper describes a verification method of automata based programs [1] based on symbolic model checking algorithms [2]. Author makes an attempt to develop verification method that can automate process of verification and can be useful for peoples unacquainted with model checking algorithms or tools.

  12. 40 CFR 1065.342 - Sample dryer verification.

    Science.gov (United States)

    2010-07-01

    ...-membrane dryer or thermal chiller. (d) Sample dryer verification procedure. Use the following method to... specifications plus 0.002 mol/mol. (e) Alternate sample dryer verification procedure. The following method may be... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Sample dryer verification. 1065.342...

  13. A Domain-specific Framework for Automated Construction and Verification of Railway Control Systems

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth

    2009-01-01

    The development of modern railway and tramway control systems represents a considerable challenge to both systems and software engineers: The goal to increase the traffic throughput while at the same time increasing the availability and reliability of railway operations leads to a demand for more...... in a demand for a higher degree of automation for the development verification, validation and test phases of projects, without impairing the thoroughness of safety-related quality measures and certification activities. Motivated by these considerations, this presentation describes an approach for automated...... construction and verification of railway control systems....

  14. Integrated Disposal Facility FY 2016: ILAW Verification and Validation of the eSTOMP Simulator

    Energy Technology Data Exchange (ETDEWEB)

    Freedman, Vicky L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bacon, Diana H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Fang, Yilin [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-05-13

    This document describes two sets of simulations carried out to further verify and validate the eSTOMP simulator. In this report, a distinction is made between verification and validation, and the focus is on verifying eSTOMP through a series of published benchmarks on cementitious wastes, and validating eSTOMP based on a lysimeter experiment for the glassified waste. These activities are carried out within the context of a scientific view of validation that asserts that models can only be invalidated, and that model validation (and verification) is a subjective assessment.

  15. A Methodology for Evaluating Artifacts Produced by a Formal Verification Process

    Science.gov (United States)

    Siminiceanu, Radu I.; Miner, Paul S.; Person, Suzette

    2011-01-01

    The goal of this study is to produce a methodology for evaluating the claims and arguments employed in, and the evidence produced by formal verification activities. To illustrate the process, we conduct a full assessment of a representative case study for the Enabling Technology Development and Demonstration (ETDD) program. We assess the model checking and satisfiabilty solving techniques as applied to a suite of abstract models of fault tolerant algorithms which were selected to be deployed in Orion, namely the TTEthernet startup services specified and verified in the Symbolic Analysis Laboratory (SAL) by TTTech. To this end, we introduce the Modeling and Verification Evaluation Score (MVES), a metric that is intended to estimate the amount of trust that can be placed on the evidence that is obtained. The results of the evaluation process and the MVES can then be used by non-experts and evaluators in assessing the credibility of the verification results.

  16. Verification of the Danish 1990, 2000 and 2010 emission inventory data

    DEFF Research Database (Denmark)

    Fauser, Patrik; Nielsen, Malene; Winther, Morten

    , agriculture, industry and waste. The data are based on the national greenhouse gas inventories for the years 1990 (base year), 2000 and 2010, as reported in 2012, and provided by the UNFCCC and EU. Inter-country comparison and time series consistency check of emissions and implied emission factors is made...... for EU15 countries, excluding Luxemburg and including Norway and Switzerland and for some verification steps also including Australia, Canada, Japan, Russian Federation, USA and aggregated values for EU15 and EU27. National and inter-country verification and time trend consistency check of activity data...... is made with data for energy consumption (Eurostat), agricultural statistics (Eurostat), industrial processes (UN) and waste disposal (OECD). Verification in this approach is a combination of qualitative and quantitative assessments and can assist to identify sectors and categories that require more...

  17. Monitoring/Verification using DMS: TATP Example

    Energy Technology Data Exchange (ETDEWEB)

    Stephan Weeks; Kevin Kyle

    2008-03-01

    Field-rugged and field-programmable differential mobility spectrometry (DMS) networks provide highly selective, universal monitoring of vapors and aerosols at detectable levels from persons or areas involved with illicit chemical/biological/explosives (CBE) production. CBE sensor motes used in conjunction with automated fast gas chromatography with DMS detection (GC/DMS) verification instrumentation integrated into situational operations management systems can be readily deployed and optimized for changing application scenarios. The feasibility of developing selective DMS motes for a 'smart dust' sampling approach with guided, highly selective, fast GC/DMS verification analysis is a compelling approach to minimize or prevent the use of explosives or chemical and biological weapons in terrorist activities. Two peroxide-based liquid explosives, triacetone triperoxide (TATP) and hexamethylene triperoxide diamine (HMTD), are synthesized from common chemicals such as hydrogen peroxide, acetone, sulfuric acid, ammonia, and citric acid (Figure 1). Recipes can be readily found on the Internet by anyone seeking to generate sufficient quantities of these highly explosive chemicals to cause considerable collateral damage. Detection of TATP and HMTD by advanced sensing systems can provide the early warning necessary to prevent terror plots from coming to fruition. DMS is currently one of the foremost emerging technologies for the separation and detection of gas-phase chemical species. This is due to trace-level detection limits, high selectivity, and small size. DMS separates and identifies ions at ambient pressures by utilizing the non-linear dependence of an ion's mobility on the radio frequency (rf) electric field strength. GC is widely considered to be one of the leading analytical methods for the separation of chemical species in complex mixtures. Advances in the technique have led to the development of low-thermal-mass fast GC columns. These columns are

  18. A Verification and Analysis of the USAF/DoD Fatigue Model and Fatigue Management Technology

    Science.gov (United States)

    2005-11-01

    We Nap: Evolution, Chronobiology, and Functions of Polyphasic and Ultrashort Sleep . Stampi, C. (ed) Birkhduser, Boston. Defense Acquisition...Windows® soffivare application of the Sleep , Activity, Fatigue, and Task Effectiveness (SAFTE) applied model. The application, the Fatigue Avoidance...Scheduling Tool (FASTTM) was re-engineered as a clone from the SAFTE specification. The verification considered nine sleep /wake schedules that were

  19. Cleanup Verification Package for the 118-F-5 PNL Sawdust Pit

    Energy Technology Data Exchange (ETDEWEB)

    L. D. Habel

    2008-05-20

    This cleanup verification package documents completion of remedial action, sampling activities, and compliance with cleanup criteria for the 118-F-5 Burial Ground, the PNL (Pacific Northwest Laboratory) Sawdust Pit. The 118-F-5 Burial Ground was an unlined trench that received radioactive sawdust from the floors of animal pens in the 100-F Experimental Animal Farm.

  20. Semi-automated repair verification of aerial images

    Science.gov (United States)

    Poortinga, Eric; Schereubl, Thomas; Richter, Rigo

    2009-04-01

    Using aerial image metrology to qualify repairs of defects on photomasks is an industry standard. Aerial image metrology provides reasonable matching of lithographic imaging performance without the need for wafer prints. Utilization of this capability by photomask manufacturers has risen due to the increased complexity of layouts incorporating RET and phase shift technologies. Tighter specifications by end-users have pushed aerial image metrology activities to now include CD performance results in addition to the traditional intensity performance results. Discussed is the computer implemented semi-automated analysis of aerial images for repair verification activities. Newly designed user interfaces and algorithms could guide users through predefined analysis routines as to minimize errors. There are two main routines discussed here, one allowing multiple reference sites along with a test/defect site on a single image of repeating features. The second routine compares a test/defect measurement image with a reference measurement image. This paper highlights new functionality desirable for aerial image analysis as well as describes possible ways of its realization. Using structured analysis processes and innovative analysis tools could lead to a highly efficient and more reliable result reporting of repair verification metrology.

  1. A Comparison of Modular Verification Techniques

    DEFF Research Database (Denmark)

    Andersen, Henrik Reif; Staunstrup, Jørgen; Maretti, Niels

    1997-01-01

    This paper presents and compares three techniques for mechanized verification of state oriented design descriptions. One is a traditional forwardgeneration of a fixed point characterizing the reachable states. The two others can utilize a modular structure provided by the designer. Onerequires...

  2. 14 CFR 460.17 - Verification program.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Verification program. 460.17 Section 460.17 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... program. An operator must successfully verify the integrated performance of a vehicle's hardware and any...

  3. Safe Neighborhood Computation for Hybrid System Verification

    Directory of Open Access Journals (Sweden)

    Yi Deng

    2015-01-01

    Full Text Available For the design and implementation of engineering systems, performing model-based analysis can disclose potential safety issues at an early stage. The analysis of hybrid system models is in general difficult due to the intrinsic complexity of hybrid dynamics. In this paper, a simulation-based approach to formal verification of hybrid systems is presented.

  4. Standardized Definitions for Code Verification Test Problems

    Energy Technology Data Exchange (ETDEWEB)

    Doebling, Scott William [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-09-14

    This document contains standardized definitions for several commonly used code verification test problems. These definitions are intended to contain sufficient information to set up the test problem in a computational physics code. These definitions are intended to be used in conjunction with exact solutions to these problems generated using Exact- Pack, www.github.com/lanl/exactpack.

  5. Patient position verification with oblique radiation beams

    NARCIS (Netherlands)

    Sijtsema, Nanna M.; van den Bergh, Alfons C. M.; Burlage, Fred R.; Bijl, Henk P.; Langendijk, Johannes A.; Meertens, Harm

    2007-01-01

    Purpose: In this study we investigated whether the position of head and neck cancer patients during radiotherapy could be determined from portal images of oblique radiation beams. Currently applied additional anterior posterior (AP) and lateral verification beams could then be abandoned. Method: The

  6. Mechanical verification of Lamport's Bakery algorithm

    NARCIS (Netherlands)

    Hesselink, Wim H.

    2013-01-01

    Proof assistants like PVS can be used fruitfully for the design and verification of concurrent algorithms. The technique is presented here by applying it to Lamport's Bakery algorithm. The proofs for safety properties such as mutual exclusion, first-come first-served, and absence of deadlock are

  7. Unification & sharing in timed automata verification

    DEFF Research Database (Denmark)

    David, Alexandre; Behrmann, Gerd; Larsen, Kim Guldstrand

    2003-01-01

    We present the design of the model-checking engine and internal data structures for the next generation of UPPAAL. The design is based on a pipeline architecture where each stage represents one independent operation in the verification algorithms. The architecture is based on essentially one shar...

  8. Gender, Legitimation, and Identity Verification in Groups

    Science.gov (United States)

    Burke, Peter J.; Stets, Jan E.; Cerven, Christine

    2007-01-01

    Drawing upon identity theory, expectation states theory, and legitimation theory, we examine how the task leader identity in task-oriented groups is more likely to be verified for persons with high status characteristics. We hypothesize that identity verification will be accomplished more readily for male group members and legitimated task leaders…

  9. ENVIRONMENTAL TECHNOLOGY VERIFICATION OF BAGHOUSE FILTRATION PRODUCTS

    Science.gov (United States)

    The Environmental Technology Verification Program (ETV) was started by EPA in 1995 to generate independent credible data on the performance of innovative technologies that have potential to improve protection of public health and the environment. ETV does not approve or certify p...

  10. Verification of Entrance Dose Measurements with ...

    African Journals Online (AJOL)

    Verification of Entrance Dose Measurements with Thermoluminescent Dosimeters in Conventional Radiotherapy Procedures Delivered with Co‑60 Teletherapy Machine. ... Subjects and Methods: Fifty‑seven patients with cancers of the breast, pelvis, head and neck were admitted for this study. TLD system at the Radiation ...

  11. A Verification Framework for Agent Communication

    NARCIS (Netherlands)

    Eijk, R.M. van; Boer, F.S. de; Hoek, W. van der; Meyer, J-J.Ch.

    2003-01-01

    In this paper, we introduce a verification method for the correctness of multiagent systems as described in the framework of acpl (Agent Communication Programming Language). The computational model of acpl consists of an integration of the two different paradigms of ccp (Concurrent Constraint

  12. Verification of method performance for clinical laboratories.

    Science.gov (United States)

    Nichols, James H

    2009-01-01

    Method verification, a one-time process to determine performance characteristics before a test system is utilized for patient testing, is often confused with method validation, establishing the performance of a new diagnostic tool such as an internally developed or modified method. A number of international quality standards (International Organization for Standardization (ISO) and Clinical Laboratory Standards Institute (CLSI)), accreditation agency guidelines (College of American Pathologists (CAP), Joint Commission, U.K. Clinical Pathology Accreditation (CPA)), and regional laws (Clinical Laboratory Improvement Amendments of 1988 (CLIA'88)) exist describing the requirements for method verification and validation. Consumers of marketed test kits should verify method accuracy, precision, analytic measurement range, and the appropriateness of reference intervals to the institution's patient population. More extensive validation may be required for new methods and those manufacturer methods that have been modified by the laboratory, including analytic sensitivity and specificity. This manuscript compares the various recommendations for method verification and discusses the CLSI evaluation protocols (EP) that are available to guide laboratories in performing method verification experiments.

  13. Specification, Verification and Optimisation of Business Processes

    DEFF Research Database (Denmark)

    Herbert, Luke Thomas

    Model and Notation (BPMN). The automated analysis of business processes is done by means of quantitative probabilistic model checking which allows verification of validation and performance properties through use of an algorithm for the translation of business process models into a format amenable...

  14. Mesoscale model forecast verification during monsoon 2008

    Indian Academy of Sciences (India)

    Almost all the studies are based on either National Center for Environmental Prediction (NCEP), USA, final analysis fields (NCEP FNL) or the reanalysis data used as initial and lateral boundary conditions for driving the mesoscale model. Here we present a mesoscale model forecast verification and intercomparison study ...

  15. Verification of FPGA-Signal using the test board which is applied to Safety-related controller

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Youn-Hu; Yoo, Kwanwoo; Lee, Myeongkyun; Yun, Donghwa [SOOSAN ENS, Seoul (Korea, Republic of)

    2016-10-15

    This article aims to provide the verification method for BGA-type FPGA of Programmable Logic Controller (PLC) developed as Safety Class. The logic of FPGA in the control device with Safety Class is the circuit to control overall logic of PLC. Saftety-related PLC must meet the international standard specifications. With this reason, we use V and V according to an international standard in order to secure high reliability and safety. By using this, we are supposed to proceed to a variety of verification courses for extra reliability and safety analysis. In order to have efficient verification of test results, we propose the test using the newly changed BGA socket which can resolve the problems of the conventional socket on this paper. The Verification of processes is divided into verification of Hardware and firmware. That processes are carried out in the unit testing and integration testing. The proposed test method is simple, the effect of cost reductions by batch process. In addition, it is advantageous to measure the signal from the Hi-speed-IC due to its short length of the pins and it was plated with the copper around it. Further, it also to prevent abrasion on the IC ball because it has no direct contact with the PCB. Therefore, it can be actually applied is to the BGA package test and we can easily verify logic as well as easily checking the operation of the designed data.

  16. Post-silicon and runtime verification for modern processors

    CERN Document Server

    Wagner, Ilya

    2010-01-01

    The purpose of this book is to survey the state of the art and evolving directions in post-silicon and runtime verification. The authors start by giving an overview of the state of the art in verification, particularly current post-silicon methodologies in use in the industry, both for the domain of processor pipeline design and for memory subsystems. They then dive into the presentation of several new post-silicon verification solutions aimed at boosting the verification coverage of modern processors, dedicating several chapters to this topic. The presentation of runtime verification solution

  17. When Does Length Cause the Word Length Effect?

    Science.gov (United States)

    Jalbert, Annie; Neath, Ian; Bireta, Tamra J.; Surprenant, Aimee M.

    2011-01-01

    The word length effect, the finding that lists of short words are better recalled than lists of long words, has been termed one of the benchmark findings that any theory of immediate memory must account for. Indeed, the effect led directly to the development of working memory and the phonological loop, and it is viewed as the best remaining…

  18. CEBAF Upgrade Bunch Length Measurements

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, Mahmoud [Old Dominion Univ., Norfolk, VA (United States)

    2016-05-01

    Many accelerators use short electron bunches and measuring the bunch length is important for efficient operations. CEBAF needs a suitable bunch length because bunches that are too long will result in beam interruption to the halls due to excessive energy spread and beam loss. In this work, bunch length is measured by invasive and non-invasive techniques at different beam energies. Two new measurement techniques have been commissioned; a harmonic cavity showed good results compared to expectations from simulation, and a real time interferometer is commissioned and first checkouts were performed. Three other techniques were used for measurements and comparison purposes without modifying the old procedures. Two of them can be used when the beam is not compressed longitudinally while the other one, the synchrotron light monitor, can be used with compressed or uncompressed beam.

  19. Continuously variable focal length lens

    Science.gov (United States)

    Adams, Bernhard W; Chollet, Matthieu C

    2013-12-17

    A material preferably in crystal form having a low atomic number such as beryllium (Z=4) provides for the focusing of x-rays in a continuously variable manner. The material is provided with plural spaced curvilinear, optically matched slots and/or recesses through which an x-ray beam is directed. The focal length of the material may be decreased or increased by increasing or decreasing, respectively, the number of slots (or recesses) through which the x-ray beam is directed, while fine tuning of the focal length is accomplished by rotation of the material so as to change the path length of the x-ray beam through the aligned cylindrical slows. X-ray analysis of a fixed point in a solid material may be performed by scanning the energy of the x-ray beam while rotating the material to maintain the beam's focal point at a fixed point in the specimen undergoing analysis.

  20. Utterance Verification for Text-Dependent Speaker Recognition

    DEFF Research Database (Denmark)

    Kinnunen, Tomi; Sahidullah, Md; Kukanov, Ivan

    2016-01-01

    Text-dependent automatic speaker verification naturally calls for the simultaneous verification of speaker identity and spoken content. These two tasks can be achieved with automatic speaker verification (ASV) and utterance verification (UV) technologies. While both have been addressed previously...... in the literature, a treatment of simultaneous speaker and utterance verification with a modern, standard database is so far lacking. This is despite the burgeoning demand for voice biometrics in a plethora of practical security applications. With the goal of improving overall verification performance, this paper...... reports different strategies for simultaneous ASV and UV in the context of short-duration, text-dependent speaker verification. Experiments performed on the recently released RedDots corpus are reported for three different ASV systems and four different UV systems. Results show that the combination...

  1. Assessing impact of climate change on season length in Karnataka ...

    Indian Academy of Sciences (India)

    Changes in seasons and season length are an indicator, as well as an effect, of climate change. Seasonal change profoundly affects the balance of life in ecosystems and impacts essential human activities such as agriculture and irrigation. This study investigates the uncertainty of season length in Karnataka state, India, ...

  2. Kondo length in bosonic lattices

    Science.gov (United States)

    Giuliano, Domenico; Sodano, Pasquale; Trombettoni, Andrea

    2017-09-01

    Motivated by the fact that the low-energy properties of the Kondo model can be effectively simulated in spin chains, we study the realization of the effect with bond impurities in ultracold bosonic lattices at half filling. After presenting a discussion of the effective theory and of the mapping of the bosonic chain onto a lattice spin Hamiltonian, we provide estimates for the Kondo length as a function of the parameters of the bosonic model. We point out that the Kondo length can be extracted from the integrated real-space correlation functions, which are experimentally accessible quantities in experiments with cold atoms.

  3. Slip length measurement using BBM

    Science.gov (United States)

    Ahmadzadegan, Adib; Snoeyink, Craig

    2015-11-01

    We will be presenting experimental characterizations of slip lengths of fluids in nano/micro channels. These channels are becoming increasingly important in sensor and separations applications. However, crucial questions still remain on the mechanisms that govern slip-length behavior. We used Bessel Beam microscopy (BBM), a novel super-resolution imaging system, in conjunction with TIRF system. These two, together led us to be able to do Particle Tracking Velocimetry with significantly higher accuracy than previously possible. We will be presenting results demonstrating the feasibility of this approach and advantages that make this method unique.

  4. Fitting Noise Management Signal Processing Applying the American Academy of Audiology Pediatric Amplification Guideline: Verification Protocols.

    Science.gov (United States)

    Scollie, Susan; Levy, Charla; Pourmand, Nazanin; Abbasalipour, Parvaneh; Bagatto, Marlene; Richert, Frances; Moodie, Shane; Crukley, Jeff; Parsa, Vijay

    2016-03-01

    Although guidelines for fitting hearing aids for children are well developed and have strong basis in evidence, specific protocols for fitting and verifying some technologies are not always available. One such technology is noise management in children's hearing aids. Children are frequently in high-level and/or noisy environments, and many options for noise management exist in modern hearing aids. Verification protocols are needed to define specific test signals and levels for use in clinical practice. This work aims to (1) describe the variation in different brands of noise reduction processors in hearing aids and the verification of these processors and (2) determine whether these differences are perceived by 13 children who have hearing loss. Finally, we aimed to develop a verification protocol for use in pediatric clinical practice. A set of hearing aids was tested using both clinically available test systems and a reference system, so that the impacts of noise reduction signal processing in hearing aids could be characterized for speech in a variety of background noises. A second set of hearing aids was tested across a range of audiograms and across two clinical verification systems to characterize the variance in clinical verification measurements. Finally, a set of hearing aid recordings that varied by type of noise reduction was rated for sound quality by children with hearing loss. Significant variation across makes and models of hearing aids was observed in both the speed of noise reduction activation and the magnitude of noise reduction. Reference measures indicate that noise-only testing may overestimate noise reduction magnitude compared to speech-in-noise testing. Variation across clinical test signals was also observed, indicating that some test signals may be more successful than others for characterization of hearing aid noise reduction. Children provided different sound quality ratings across hearing aids, and for one hearing aid rated the sound

  5. An analysis of clinical activity, admission rates, length of hospital stay, and economic impact after a temporary loss of 50% of the non-operative podiatrists from a tertiary specialist foot clinic in the United Kingdom.

    Science.gov (United States)

    Gooday, Catherine; Murchison, Rachel; Dhatariya, Ketan

    2013-01-01

    Podiatrists form an integral part of the multidisciplinary foot team in the treatment of diabetic foot-related complications. A set of unforeseen circumstances within our specialist diabetes foot service in the United Kingdom caused a loss of 50% of our non-operative podiatry team for almost 7 months during 2010. Some of this time was filled by non-specialist community non-operative podiatrists. We assessed the economic impact of this loss by examining data for the 5 years prior to this 7-month interruption, and for the 2 years after 'normal service' was resumed. Our data show that the loss of the non-operative podiatrists led to a significant rise in the numbers of admissions into hospital, and hospital length of stay also increased. At our institution a single bed day cost is £275. During the time that the numbers of specialist non-operative podiatry staff were depleted, and for up to 6 months after they returned to normal activities, the extra costs increased by just less than £90,000. The number of people admitted directly from specialist vascular and orthopaedic clinics is likely to have increased due to the lack of capacity to manage them in the diabetic foot clinic. Our data were unable to assess these individuals and did not look at the costs saved from avoiding surgery. Thus the actual costs incurred are likely to be higher. Our data suggest that specialist non-operative podiatrists involved in the treatment of the diabetic foot may prevent unwarranted hospital admission and increased hospitalisation rates by providing skilled assessment and care in the outpatient clinical settings.

  6. Verification survey report of the south waste tank farm training/test tower and hazardous waste storage lockers at the West Valley demonstration project, West Valley, New York

    Energy Technology Data Exchange (ETDEWEB)

    Weaver, Phyllis C.

    2012-08-29

    A team from ORAU's Independent Environmental Assessment and Verification Program performed verification survey activities on the South Test Tower and four Hazardous Waste Storage Lockers. Scan data collected by ORAU determined that both the alpha and alpha-plus-beta activity was representative of radiological background conditions. The count rate distribution showed no outliers that would be indicative of alpha or alpha-plus-beta count rates in excess of background. It is the opinion of ORAU that independent verification data collected support the site?s conclusions that the South Tower and Lockers sufficiently meet the site criteria for release to recycle and reuse.

  7. Cognitive Bias in the Verification and Validation of Space Flight Systems

    Science.gov (United States)

    Larson, Steve

    2012-01-01

    Cognitive bias is generally recognized as playing a significant role in virtually all domains of human decision making. Insight into this role is informally built into many of the system engineering practices employed in the aerospace industry. The review process, for example, typically has features that help to counteract the effect of bias. This paper presents a discussion of how commonly recognized biases may affect the verification and validation process. Verifying and validating a system is arguably more challenging than development, both technically and cognitively. Whereas there may be a relatively limited number of options available for the design of a particular aspect of a system, there is a virtually unlimited number of potential verification scenarios that may be explored. The probability of any particular scenario occurring in operations is typically very difficult to estimate, which increases reliance on judgment that may be affected by bias. Implementing a verification activity often presents technical challenges that, if they can be overcome at all, often result in a departure from actual flight conditions (e.g., 1-g testing, simulation, time compression, artificial fault injection) that may raise additional questions about the meaningfulness of the results, and create opportunities for the introduction of additional biases. In addition to mitigating the biases it can introduce directly, the verification and validation process must also overcome the cumulative effect of biases introduced during all previous stages of development. A variety of cognitive biases will be described, with research results for illustration. A handful of case studies will be presented that show how cognitive bias may have affected the verification and validation process on recent JPL flight projects, identify areas of strength and weakness, and identify potential changes or additions to commonly used techniques that could provide a more robust verification and validation of

  8. From Livingstone to SMV: Formal Verification for Autonomous Spacecrafts

    Science.gov (United States)

    Pecheur, Charles; Simmons, Reid

    2000-01-01

    To fulfill the needs of its deep space exploration program, NASA is actively supporting research and development in autonomy software. However, the reliable and cost-effective development and validation of autonomy systems poses a tough challenge. Traditional scenario-based testing methods fall short because of the combinatorial explosion of possible situations to be analyzed, and formal verification techniques typically require a tedious, manual modelling by formal method experts. This paper presents the application of formal verification techniques in the development of autonomous controllers based on Livingstone, a model-based health-monitoring system that can detect and diagnose anomalies and suggest possible recovery actions. We present a translator that converts the models used by Livingstone into specifications that can be verified with the SMV model checker. The translation frees the Livingstone developer from the tedious conversion of his design to SMV, and isolates him from the technical details of the SMV program. We describe different aspects of the translation and briefly discuss its application to several NASA domains.

  9. Verification and Validation Issues in Systems of Systems

    Directory of Open Access Journals (Sweden)

    Eric Honour

    2013-11-01

    Full Text Available The cutting edge in systems development today is in the area of "systems of systems" (SoS large networks of inter-related systems that are developed and managed separately, but that also perform collective activities. Such large systems typically involve constituent systems operating with different life cycles, often with uncoordinated evolution. The result is an ever-changing SoS in which adaptation and evolution replace the older engineering paradigm of "development". This short paper presents key thoughts about verification and validation in this environment. Classic verification and validation methods rely on having (a a basis of proof, in requirements and in operational scenarios, and (b a known system configuration to be proven. However, with constant SoS evolution, management of both requirements and system configurations are problematic. Often, it is impossible to maintain a valid set of requirements for the SoS due to the ongoing changes in the constituent systems. Frequently, it is even difficult to maintain a vision of the SoS operational use as users find new ways to adapt the SoS. These features of the SoS result in significant challenges for system proof. In addition to discussing the issues, the paper also indicates some of the solutions that are currently used to prove the SoS.

  10. Femur length and biparietal diameter

    African Journals Online (AJOL)

    2014-12-02

    Dec 2, 2014 ... Conclusion: The fetal parameters used in this study were consistently smaller than reported values from European studies up to the 34th week of ... parameters include crown‑rump length, abdominal circumference, femur ... the continuous mid‑line echo is broken by the cavum septi pellucidi, and taken from ...

  11. How to measure path length?

    NARCIS (Netherlands)

    Stroeven, P.

    2015-01-01

    Path length measuring is a relevant engineering problem. Leonardo Da Vinci designed for the military appropriate equipment, the podometer, to do so. Modern equipment such as step meters and map meters are quite similar to Da Vinci?s design, despite geometrical statistical - stereological - methods

  12. From Wireless Sensor Networks to Wireless Body Area Networks: Formal Modeling and Verification on Security Using PAT

    Directory of Open Access Journals (Sweden)

    Tieming Chen

    2016-01-01

    Full Text Available Model checking has successfully been applied on verification of security protocols, but the modeling process is always tedious and proficient knowledge of formal method is also needed although the final verification could be automatic depending on specific tools. At the same time, due to the appearance of novel kind of networks, such as wireless sensor networks (WSN and wireless body area networks (WBAN, formal modeling and verification for these domain-specific systems are quite challenging. In this paper, a specific and novel formal modeling and verification method is proposed and implemented using an expandable tool called PAT to do WSN-specific security verification. At first, an abstract modeling data structure for CSP#, which is built in PAT, is developed to support the node mobility related specification for modeling location-based node activity. Then, the traditional Dolev-Yao model is redefined to facilitate modeling of location-specific attack behaviors on security mechanism. A throughout formal verification application on a location-based security protocol in WSN is described in detail to show the usability and effectiveness of the proposed methodology. Furthermore, also a novel location-based authentication security protocol in WBAN can be successfully modeled and verified directly using our method, which is, to the best of our knowledge, the first effort on employing model checking for automatic analysis of authentication protocol for WBAN.

  13. Formal Verification, Engineering and Business Value

    Directory of Open Access Journals (Sweden)

    Ralf Huuck

    2012-12-01

    Full Text Available How to apply automated verification technology such as model checking and static program analysis to millions of lines of embedded C/C++ code? How to package this technology in a way that it can be used by software developers and engineers, who might have no background in formal verification? And how to convince business managers to actually pay for such a software? This work addresses a number of those questions. Based on our own experience on developing and distributing the Goanna source code analyzer for detecting software bugs and security vulnerabilities in C/C++ code, we explain the underlying technology of model checking, static analysis and SMT solving, steps involved in creating industrial-proof tools.

  14. Verification of Building Blocks for Asynchronous Circuits

    Directory of Open Access Journals (Sweden)

    Freek Verbeek

    2013-04-01

    Full Text Available Scalable formal verification constitutes an important challenge for the design of asynchronous circuits. Deadlock freedom is a property that is desired but hard to verify. It is an emergent property that has to be verified monolithically. We present our approach to using ACL2 to verify necessary and sufficient conditions over asynchronous delay-insensitive primitives. These conditions are used to derive SAT/SMT instances from circuits built out of these primitives. These SAT/SMT instances help in establishing absence of deadlocks. Our verification effort consists of building an executable checker in the ACL2 logic tailored for our purpose. We prove that this checker is correct. This approach enables us to prove ACL2 theorems involving defun-sk constructs and free variables fully automatically.

  15. Formal verification of human-automation interaction

    Science.gov (United States)

    Degani, Asaf; Heymann, Michael

    2002-01-01

    This paper discusses a formal and rigorous approach to the analysis of operator interaction with machines. It addresses the acute problem of detecting design errors in human-machine interaction and focuses on verifying the correctness of the interaction in complex and automated control systems. The paper describes a systematic methodology for evaluating whether the interface provides the necessary information about the machine to enable the operator to perform a specified task successfully and unambiguously. It also addresses the adequacy of information provided to the user via training material (e.g., user manual) about the machine's behavior. The essentials of the methodology, which can be automated and applied to the verification of large systems, are illustrated by several examples and through a case study of pilot interaction with an autopilot aboard a modern commercial aircraft. The expected application of this methodology is an augmentation and enhancement, by formal verification, of human-automation interfaces.

  16. Automated Formal Verification for PLC Control Systems

    CERN Multimedia

    Fernández Adiego, Borja

    2014-01-01

    Programmable Logic Controllers (PLCs) are widely used devices used in industrial control systems. Ensuring that the PLC software is compliant with its specification is a challenging task. Formal verification has become a recommended practice to ensure the correctness of the safety-critical software. However, these techniques are still not widely applied in industry due to the complexity of building formal models, which represent the system and the formalization of requirement specifications. We propose a general methodology to perform automated model checking of complex properties expressed in temporal logics (e.g. CTL, LTL) on PLC programs. This methodology is based on an Intermediate Model (IM), meant to transform PLC programs written in any of the languages described in the IEC 61131-3 standard (ST, IL, etc.) to different modeling languages of verification tools. This approach has been applied to CERN PLC programs validating the methodology.

  17. Packaged low-level waste verification system

    Energy Technology Data Exchange (ETDEWEB)

    Tuite, K.; Winberg, M.R.; McIsaac, C.V. [Idaho National Engineering Lab., Idaho Falls, ID (United States)

    1995-12-31

    The Department of Energy through the National Low-Level Waste Management Program and WMG Inc. have entered into a joint development effort to design, build, and demonstrate the Packaged Low-Level Waste Verification System. Currently, states and low-level radioactive waste disposal site operators have no method to independently verify the radionuclide content of packaged low-level waste that arrives at disposal sites for disposition. At this time, the disposal site relies on the low-level waste generator shipping manifests and accompanying records to ensure that low-level waste received meets the site`s waste acceptance criteria. The subject invention provides the equipment, software, and methods to enable the independent verification of low-level waste shipping records to ensure that the site`s waste acceptance criteria are being met. The objective of the prototype system is to demonstrate a mobile system capable of independently verifying the content of packaged low-level waste.

  18. Sensor-fusion-based biometric identity verification

    Energy Technology Data Exchange (ETDEWEB)

    Carlson, J.J.; Bouchard, A.M.; Osbourn, G.C.; Martinez, R.F.; Bartholomew, J.W. [Sandia National Labs., Albuquerque, NM (United States); Jordan, J.B.; Flachs, G.M.; Bao, Z.; Zhu, L. [New Mexico State Univ., Las Cruces, NM (United States). Electronic Vision Research Lab.

    1998-02-01

    Future generation automated human biometric identification and verification will require multiple features/sensors together with internal and external information sources to achieve high performance, accuracy, and reliability in uncontrolled environments. The primary objective of the proposed research is to develop a theoretical and practical basis for identifying and verifying people using standoff biometric features that can be obtained with minimal inconvenience during the verification process. The basic problem involves selecting sensors and discovering features that provide sufficient information to reliably verify a person`s identity under the uncertainties caused by measurement errors and tactics of uncooperative subjects. A system was developed for discovering hand, face, ear, and voice features and fusing them to verify the identity of people. The system obtains its robustness and reliability by fusing many coarse and easily measured features into a near minimal probability of error decision algorithm.

  19. Systems Approach to Arms Control Verification

    Energy Technology Data Exchange (ETDEWEB)

    Allen, K; Neimeyer, I; Listner, C; Stein, G; Chen, C; Dreicer, M

    2015-05-15

    Using the decades of experience of developing concepts and technologies for verifying bilateral and multilateral arms control agreements, a broad conceptual systems approach is being developed that takes into account varying levels of information and risk. The IAEA has already demonstrated the applicability of a systems approach by implementing safeguards at the State level, with acquisition path analysis as the key element. In order to test whether such an approach could also be implemented for arms control verification, an exercise was conducted in November 2014 at the JRC ITU Ispra. Based on the scenario of a hypothetical treaty between two model nuclear weapons states aimed at capping their nuclear arsenals at existing levels, the goal of this exercise was to explore how to use acquisition path analysis in an arms control context. Our contribution will present the scenario, objectives and results of this exercise, and attempt to define future workshops aimed at further developing verification measures that will deter or detect treaty violations.

  20. Spatial Verification Using Wavelet Transforms: A Review

    CERN Document Server

    Weniger, Michael; Friederichs, Petra

    2016-01-01

    Due to the emergence of new high resolution numerical weather prediction (NWP) models and the availability of new or more reliable remote sensing data, the importance of efficient spatial verification techniques is growing. Wavelet transforms offer an effective framework to decompose spatial data into separate (and possibly orthogonal) scales and directions. Most wavelet based spatial verification techniques have been developed or refined in the last decade and concentrate on assessing forecast performance (i.e. forecast skill or forecast error) on distinct physical scales. Particularly during the last five years, a significant growth in meteorological applications could be observed. However, a comparison with other scientific fields such as feature detection, image fusion, texture analysis, or facial and biometric recognition, shows that there is still a considerable, currently unused potential to derive useful diagnostic information. In order to tab the full potential of wavelet analysis, we revise the stat...

  1. Program verification using symbolic game semantics

    DEFF Research Database (Denmark)

    Dimovski, Aleksandar

    2014-01-01

    We introduce a new symbolic representation of algorithmic game semantics, and show how it can be applied for efficient verification of open (incomplete) programs. The focus is on an Algol-like programming language which contains the core ingredients of imperative and functional languages...... of game semantics to that of corresponding symbolic representations. In this way programs with infinite data types, such as integers, can be expressed as finite-state symbolic-automata although the standard automata representation is infinite-state, i.e. the standard regular-language representation has...... infinite summations. Moreover, in this way significant reductions of the state space of game semantics models are obtained. This enables efficient verification of programs by our prototype tool based on symbolic game models, which is illustrated with several examples....

  2. Formal verification of industrial control systems

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    Verification of critical software is a high priority but a challenging task for industrial control systems. For many kinds of problems, testing is not an efficient method. Formal methods, such as model checking appears to be an appropriate complementary method. However, it is not common to use model checking in industry yet, as this method needs typically formal methods expertise and huge computing power. In the EN-ICE-PLC section, we are working on a [methodology][1] and a tool ([PLCverif][2]) to overcome these challenges and to integrate formal verification in the development process of our PLC-based control systems. [1]: http://cern.ch/project-plc-formalmethods [2]: http://cern.ch/plcverif

  3. Final Report Independent Verification Survey of the High Flux Beam Reactor, Building 802 Fan House Brookhaven National Laboratory Upton, New York

    Energy Technology Data Exchange (ETDEWEB)

    Harpeneau, Evan M. [Oak Ridge Institute for Science and Education, Oak Ridge, TN (United States). Independent Environmental Assessment and Verification Program

    2011-06-24

    On May 9, 2011, ORISE conducted verification survey activities including scans, sampling, and the collection of smears of the remaining soils and off-gas pipe associated with the 802 Fan House within the HFBR (High Flux Beam Reactor) Complex at BNL. ORISE is of the opinion, based on independent scan and sample results obtained during verification activities at the HFBR 802 Fan House, that the FSS (final status survey) unit meets the applicable site cleanup objectives established for as left radiological conditions.

  4. Using timing information in speaker verification

    CSIR Research Space (South Africa)

    Van Heerden, CJ

    2005-11-01

    Full Text Available be- tween the two, since overlap between different speakers? models is inevitable. Models that are typically used include statistical mod- els when employing Hidden Markov Models (HMMs), template models when using dynamic time warping (DTW... and prevent unauthorized use of computer and communication systems [1]. Although speaker verification systems are not completely secure, they are a powerful deterrent to fraud in combination with other security measures such as pin numbers, SIM cards...

  5. Analyzing personalized policies for online biometric verification.

    Science.gov (United States)

    Sadhwani, Apaar; Yang, Yan; Wein, Lawrence M

    2014-01-01

    Motivated by India's nationwide biometric program for social inclusion, we analyze verification (i.e., one-to-one matching) in the case where we possess similarity scores for 10 fingerprints and two irises between a resident's biometric images at enrollment and his biometric images during his first verification. At subsequent verifications, we allow individualized strategies based on these 12 scores: we acquire a subset of the 12 images, get new scores for this subset that quantify the similarity to the corresponding enrollment images, and use the likelihood ratio (i.e., the likelihood of observing these scores if the resident is genuine divided by the corresponding likelihood if the resident is an imposter) to decide whether a resident is genuine or an imposter. We also consider two-stage policies, where additional images are acquired in a second stage if the first-stage results are inconclusive. Using performance data from India's program, we develop a new probabilistic model for the joint distribution of the 12 similarity scores and find near-optimal individualized strategies that minimize the false reject rate (FRR) subject to constraints on the false accept rate (FAR) and mean verification delay for each resident. Our individualized policies achieve the same FRR as a policy that acquires (and optimally fuses) 12 biometrics for each resident, which represents a five (four, respectively) log reduction in FRR relative to fingerprint (iris, respectively) policies previously proposed for India's biometric program. The mean delay is [Formula: see text] sec for our proposed policy, compared to 30 sec for a policy that acquires one fingerprint and 107 sec for a policy that acquires all 12 biometrics. This policy acquires iris scans from 32-41% of residents (depending on the FAR) and acquires an average of 1.3 fingerprints per resident.

  6. Analyzing personalized policies for online biometric verification.

    Directory of Open Access Journals (Sweden)

    Apaar Sadhwani

    Full Text Available Motivated by India's nationwide biometric program for social inclusion, we analyze verification (i.e., one-to-one matching in the case where we possess similarity scores for 10 fingerprints and two irises between a resident's biometric images at enrollment and his biometric images during his first verification. At subsequent verifications, we allow individualized strategies based on these 12 scores: we acquire a subset of the 12 images, get new scores for this subset that quantify the similarity to the corresponding enrollment images, and use the likelihood ratio (i.e., the likelihood of observing these scores if the resident is genuine divided by the corresponding likelihood if the resident is an imposter to decide whether a resident is genuine or an imposter. We also consider two-stage policies, where additional images are acquired in a second stage if the first-stage results are inconclusive. Using performance data from India's program, we develop a new probabilistic model for the joint distribution of the 12 similarity scores and find near-optimal individualized strategies that minimize the false reject rate (FRR subject to constraints on the false accept rate (FAR and mean verification delay for each resident. Our individualized policies achieve the same FRR as a policy that acquires (and optimally fuses 12 biometrics for each resident, which represents a five (four, respectively log reduction in FRR relative to fingerprint (iris, respectively policies previously proposed for India's biometric program. The mean delay is [Formula: see text] sec for our proposed policy, compared to 30 sec for a policy that acquires one fingerprint and 107 sec for a policy that acquires all 12 biometrics. This policy acquires iris scans from 32-41% of residents (depending on the FAR and acquires an average of 1.3 fingerprints per resident.

  7. Compendium of Arms Control Verification Proposals.

    Science.gov (United States)

    1982-03-01

    leurs forces militaires *en vue de dimintier les risques de d~iletichement d’uiie guerrc. Comme les bienfaits d’un tel accord Dour chaque pays...complicate verification. Bank Credit : To check on the possibility that clandestine military expenditures might be channeled through the banking system in...the guise of extensions of credit , it would be neces- sary to use similar methods to those employed concerning budget expenditures (i.e. trend analysis

  8. Verification of the databases EXFOR and ENDF

    Directory of Open Access Journals (Sweden)

    Berton Gottfried

    2017-01-01

    Full Text Available The objective of this work is for the verification of large experimental (EXFOR and evaluated nuclear reaction databases (JEFF, ENDF, JENDL, TENDL…. The work is applied to neutron reactions in EXFOR data, including threshold reactions, isomeric transitions, angular distributions and data in the resonance region of both isotopes and natural elements. Finally, a comparison of the resonance integrals compiled in EXFOR database with those derived from the evaluated libraries is also performed.

  9. Survey of Existing Tools for Formal Verification.

    Energy Technology Data Exchange (ETDEWEB)

    Punnoose, Ratish J.; Armstrong, Robert C.; Wong, Matthew H.; Jackson, Mayo

    2014-12-01

    Formal methods have come into wide use because of their effectiveness in verifying "safety and security" requirements of digital systems; a set of requirements for which testing is mostly ineffective. Formal methods are routinely used in the design and verification of high-consequence digital systems in industry. This report outlines our work in assessing the capabilities of commercial and open source formal tools and the ways in which they can be leveraged in digital design workflows.

  10. Secure Image Hash Comparison for Warhead Verification

    Energy Technology Data Exchange (ETDEWEB)

    Bruillard, Paul J.; Jarman, Kenneth D.; Robinson, Sean M.

    2014-06-06

    The effort to inspect and verify warheads in the context of possible future arms control treaties is rife with security and implementation issues. In this paper we review prior work on perceptual image hashing for template-based warhead verification. Furthermore, we formalize the notion of perceptual hashes and demonstrate that large classes of such functions are likely not cryptographically secure. We close with a brief discussion of fully homomorphic encryption as an alternative technique.

  11. Reproducible Research, Uncertainty Quantification, and Verification & Validation

    OpenAIRE

    Barba, Lorena A.

    2014-01-01

    Slides used with my presentation in the SIAM Uncertainty Quantification Conference 2014, Minisymposium on "The Reliability of Computational Research Findings: Reproducible Research, Uncertainty Quantification, and Verification & Validation." The talk used an audience response system to collect True/False or Yes/No opinions on 13 statements/questions: 1) Computer simulations create scientific knowledge.  2) Simulation is a method 3) A reproducible simulation does not need to be acc...

  12. Pedestrian flow simulation validation and verification techniques

    OpenAIRE

    Dridi, Mohamed H.

    2015-01-01

    For the verification and validation of microscopic simulation models of pedestrian flow, we have performed experiments for different kind of facilities and sites where most conflicts and congestion happens e.g. corridors, narrow passages, and crosswalks. The validity of the model should compare the experimental conditions and simulation results with video recording carried out in the same condition like in real life e.g. pedestrian flux and density distributions. The strategy in this techniqu...

  13. Deductive Verification of a Hypervisor Model

    OpenAIRE

    Rusu, Vlad; Grimaud, Gilles; Hauspie, Michaël; Serman, François

    2017-01-01

    (27 pages); We propose a deductive-verification approach for proving partial-correctness and invariance properties on arbitrary transition systems, and demonstrate it on a security hypervisor model for machine code. Regarding partial correctness, we generalise the recently-introduced formalism of Reachability Logic, currently used as a language-parametric program logic, to arbitrary transition systems. We propose a sound and relatively-complete proof system for the resulting logic. The soundn...

  14. DOE handbook: Integrated safety management systems (ISMS) verification team leader`s handbook

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-06-01

    The primary purpose of this handbook is to provide guidance to the ISMS verification Team Leader and the verification team in conducting ISMS verifications. The handbook describes methods and approaches for the review of the ISMS documentation (Phase I) and ISMS implementation (Phase II) and provides information useful to the Team Leader in preparing the review plan, selecting and training the team, coordinating the conduct of the verification, and documenting the results. The process and techniques described are based on the results of several pilot ISMS verifications that have been conducted across the DOE complex. A secondary purpose of this handbook is to provide information useful in developing DOE personnel to conduct these reviews. Specifically, this handbook describes methods and approaches to: (1) Develop the scope of the Phase 1 and Phase 2 review processes to be consistent with the history, hazards, and complexity of the site, facility, or activity; (2) Develop procedures for the conduct of the Phase 1 review, validating that the ISMS documentation satisfies the DEAR clause as amplified in DOE Policies 450.4, 450.5, 450.6 and associated guidance and that DOE can effectively execute responsibilities as described in the Functions, Responsibilities, and Authorities Manual (FRAM); (3) Develop procedures for the conduct of the Phase 2 review, validating that the description approved by the Approval Authority, following or concurrent with the Phase 1 review, has been implemented; and (4) Describe a methodology by which the DOE ISMS verification teams will be advised, trained, and/or mentored to conduct subsequent ISMS verifications. The handbook provides proven methods and approaches for verifying that commitments related to the DEAR, the FRAM, and associated amplifying guidance are in place and implemented in nuclear and high risk facilities. This handbook also contains useful guidance to line managers when preparing for a review of ISMS for radiological

  15. Formal verification of an avionics microprocessor

    Science.gov (United States)

    Srivas, Mandayam, K.; Miller, Steven P.

    1995-01-01

    Formal specification combined with mechanical verification is a promising approach for achieving the extremely high levels of assurance required of safety-critical digital systems. However, many questions remain regarding their use in practice: Can these techniques scale up to industrial systems, where are they likely to be useful, and how should industry go about incorporating them into practice? This report discusses a project undertaken to answer some of these questions, the formal verification of the AAMPS microprocessor. This project consisted of formally specifying in the PVS language a rockwell proprietary microprocessor at both the instruction-set and register-transfer levels and using the PVS theorem prover to show that the microcode correctly implemented the instruction-level specification for a representative subset of instructions. Notable aspects of this project include the use of a formal specification language by practicing hardware and software engineers, the integration of traditional inspections with formal specifications, and the use of a mechanical theorem prover to verify a portion of a commercial, pipelined microprocessor that was not explicitly designed for formal verification.

  16. Initial Verification and Validation Assessment for VERA

    Energy Technology Data Exchange (ETDEWEB)

    Dinh, Nam [North Carolina State Univ., Raleigh, NC (United States); Athe, Paridhi [North Carolina State Univ., Raleigh, NC (United States); Jones, Christopher [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hetzler, Adam [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Sieger, Matt [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-04-01

    The Virtual Environment for Reactor Applications (VERA) code suite is assessed in terms of capability and credibility against the Consortium for Advanced Simulation of Light Water Reactors (CASL) Verification and Validation Plan (presented herein) in the context of three selected challenge problems: CRUD-Induced Power Shift (CIPS), Departure from Nucleate Boiling (DNB), and Pellet-Clad Interaction (PCI). Capability refers to evidence of required functionality for capturing phenomena of interest while capability refers to the evidence that provides confidence in the calculated results. For this assessment, each challenge problem defines a set of phenomenological requirements against which the VERA software is assessed. This approach, in turn, enables the focused assessment of only those capabilities relevant to the challenge problem. The evaluation of VERA against the challenge problem requirements represents a capability assessment. The mechanism for assessment is the Sandia-developed Predictive Capability Maturity Model (PCMM) that, for this assessment, evaluates VERA on 8 major criteria: (1) Representation and Geometric Fidelity, (2) Physics and Material Model Fidelity, (3) Software Quality Assurance and Engineering, (4) Code Verification, (5) Solution Verification, (6) Separate Effects Model Validation, (7) Integral Effects Model Validation, and (8) Uncertainty Quantification. For each attribute, a maturity score from zero to three is assigned in the context of each challenge problem. The evaluation of these eight elements constitutes the credibility assessment for VERA.

  17. Tags and seals for arms control verification

    Energy Technology Data Exchange (ETDEWEB)

    DeVolpi, A.

    1990-09-18

    Tags and seals have long been recognized as important tools in arms control. The trend in control of armaments is to limit militarily significant equipment that is capable of being verified through direct and cooperative means, chiefly on-site inspection or monitoring. Although this paper will focus on the CFE treaty, the role of tags and seals for other treaties will also be addressed. Published technology and concepts will be reviewed, based on open sources. Arms control verification tags are defined as unique identifiers designed to be tamper-revealing; in that respect, seals are similar, being used as indicators of unauthorized access. Tamper-revealing tags might be considered as single-point markers, seals as two-point couplings, and nets as volume containment. The functions of an arms control tag can be considered to be two-fold: to provide field verification of the identity of a treaty-limited item (TLI), and to have a means of authentication of the tag and its tamper-revealing features. Authentication could take place in the field or be completed elsewhere. For CFE, the goal of tags and seals can be to reduce the overall cost of the entire verification system.

  18. VERIFICATION OF STATISTICAL CLOUDINESS ESTIMATIONS FOR EUROPE

    Directory of Open Access Journals (Sweden)

    Zoltán Imecs

    2012-03-01

    Full Text Available Verification of statistical cloudiness estimations for Europe. The climate forcing induced by cloud cover consists one of the main doubtful aspect of climate change predictions. In the case of cloudiness even the sign of the trends are not cohesive in a given region. In this sense further investigation regarding the behavior of cloudiness are indicated. In this study a statistical estimation of total cloudiness is elaborated using the method of instrumental variables. For this analyze surface-observed monthly mean cloudiness data was applied for the period of 1973-1996. In the second part of the study the verification of results is established using an independent satellite retrieved data series for the period of 2005-2011. Based on verification can be conclude that the applied statistical estimation is able to reproduce the measured values with an RMSE 7, 3%, the difference between the measured and predicted changes of cloudiness is 1.44%, found a stronger decrease of cloudiness in real data as the estimation had indicate. The main differences between the observed and predicted value is evident in the distribution of the frequencies showing a shifting towards the lower values in observed data but not recognized in the estimated values. In the geographical distribution of estimations errors sign a difference is detected between the water surfaces and continental regions.

  19. Verification in Referral-Based Crowdsourcing

    Science.gov (United States)

    Naroditskiy, Victor; Rahwan, Iyad; Cebrian, Manuel; Jennings, Nicholas R.

    2012-01-01

    Online social networks offer unprecedented potential for rallying a large number of people to accomplish a given task. Here we focus on information gathering tasks where rare information is sought through “referral-based crowdsourcing”: the information request is propagated recursively through invitations among members of a social network. Whereas previous work analyzed incentives for the referral process in a setting with only correct reports, misreporting is known to be both pervasive in crowdsourcing applications, and difficult/costly to filter out. A motivating example for our work is the DARPA Red Balloon Challenge where the level of misreporting was very high. In order to undertake a formal study of verification, we introduce a model where agents can exert costly effort to perform verification and false reports can be penalized. This is the first model of verification and it provides many directions for future research, which we point out. Our main theoretical result is the compensation scheme that minimizes the cost of retrieving the correct answer. Notably, this optimal compensation scheme coincides with the winning strategy of the Red Balloon Challenge. PMID:23071530

  20. Runtime Verification of C Memory Safety

    Science.gov (United States)

    Roşu, Grigore; Schulte, Wolfram; Şerbănuţă, Traian Florin

    C is the most widely used imperative system’s implementation language. While C provides types and high-level abstractions, its design goal has been to provide highest performance which often requires low-level access to memory. As a consequence C supports arbitrary pointer arithmetic, casting, and explicit allocation and deallocation. These operations are difficult to use, resulting in programs that often have software bugs like buffer overflows and dangling pointers that cause security vulnerabilities. We say a C program is memory safe, if at runtime it never goes wrong with such a memory access error. Based on standards for writing “good” C code, this paper proposes strong memory safety as the least restrictive formal definition of memory safety amenable for runtime verification. We show that although verification of memory safety is in general undecidable, even when restricted to closed, terminating programs, runtime verification of strong memory safety is a decision procedure for this class of programs. We verify strong memory safety of a program by executing the program using a symbolic, deterministic definition of the dynamic semantics. A prototype implementation of these ideas shows the feasibility of this approach.

  1. Verification of micro-beam irradiation

    Science.gov (United States)

    Li, Qiongge; Juang, Titania; Beth, Rachel; Chang, Sha; Oldham, Mark

    2015-01-01

    Micro-beam Radiation Therapy (MRT) is an experimental radiation therapy with provocative experimental data indicating potential for improved efficacy in some diseases. Here we demonstrated a comprehensive micro-beam verification method utilizing high resolution (50pm) PRESAGE/Micro-Optical-CT 3D Dosimetry. A small PRESAGE cylindrical dosimeter was irradiated by a novel compact Carbon-Nano-Tube (CNT) field emission based MRT system. The Percentage Depth Dose (PDD), Peak-to-Valley Dose Ratio (PVDR) and beam width (FWHM) data were obtained and analyzed from a three strips radiation experiment. A fast dose drop-off with depth, a preserved beam width with depth (an averaged FWHM across three beams remains constant (405.3um, sigma=13.2um) between depth of 3.0~14.0mm), and a high PVDR value (increases with depth from 6.3 at 3.0mm depth to 8.6 at 14.0mm depth) were discovered during this verification process. Some operating procedures such as precise dosimeter mounting, robust mechanical motions (especially rotation) and stray-light artifact management were optimized and developed to achieve a more accurate and dosimetric verification method.

  2. Length of a Hanging Cable

    Directory of Open Access Journals (Sweden)

    Eric Costello

    2011-01-01

    Full Text Available The shape of a cable hanging under its own weight and uniform horizontal tension between two power poles is a catenary. The catenary is a curve which has an equation defined by a hyperbolic cosine function and a scaling factor. The scaling factor for power cables hanging under their own weight is equal to the horizontal tension on the cable divided by the weight of the cable. Both of these values are unknown for this problem. Newton's method was used to approximate the scaling factor and the arc length function to determine the length of the cable. A script was written using the Python programming language in order to quickly perform several iterations of Newton's method to get a good approximation for the scaling factor.

  3. Abstraction and Learning for Infinite-State Compositional Verification

    Directory of Open Access Journals (Sweden)

    Dimitra Giannakopoulou

    2013-09-01

    Full Text Available Despite many advances that enable the application of model checking techniques to the verification of large systems, the state-explosion problem remains the main challenge for scalability. Compositional verification addresses this challenge by decomposing the verification of a large system into the verification of its components. Recent techniques use learning-based approaches to automate compositional verification based on the assume-guarantee style reasoning. However, these techniques are only applicable to finite-state systems. In this work, we propose a new framework that interleaves abstraction and learning to perform automated compositional verification of infinite-state systems. We also discuss the role of learning and abstraction in the related context of interface generation for infinite-state components.

  4. Automatic Verification of Timing Constraints for Safety Critical Space Systems

    Science.gov (United States)

    Fernandez, Javier; Parra, Pablo; Sanchez Prieto, Sebastian; Polo, Oscar; Bernat, Guillem

    2015-09-01

    In this paper is presented an automatic process of verification. We focus in the verification of scheduling analysis parameter. This proposal is part of process based on Model Driven Engineering to automate a Verification and Validation process of the software on board of satellites. This process is implemented in a software control unit of the energy particle detector which is payload of Solar Orbiter mission. From the design model is generated a scheduling analysis model and its verification model. The verification as defined as constraints in way of Finite Timed Automatas. When the system is deployed on target the verification evidence is extracted as instrumented points. The constraints are fed with the evidence, if any of the constraints is not satisfied for the on target evidence the scheduling analysis is not valid.

  5. Verification and Validation Studies for the LAVA CFD Solver

    Science.gov (United States)

    Moini-Yekta, Shayan; Barad, Michael F; Sozer, Emre; Brehm, Christoph; Housman, Jeffrey A.; Kiris, Cetin C.

    2013-01-01

    The verification and validation of the Launch Ascent and Vehicle Aerodynamics (LAVA) computational fluid dynamics (CFD) solver is presented. A modern strategy for verification and validation is described incorporating verification tests, validation benchmarks, continuous integration and version control methods for automated testing in a collaborative development environment. The purpose of the approach is to integrate the verification and validation process into the development of the solver and improve productivity. This paper uses the Method of Manufactured Solutions (MMS) for the verification of 2D Euler equations, 3D Navier-Stokes equations as well as turbulence models. A method for systematic refinement of unstructured grids is also presented. Verification using inviscid vortex propagation and flow over a flat plate is highlighted. Simulation results using laminar and turbulent flow past a NACA 0012 airfoil and ONERA M6 wing are validated against experimental and numerical data.

  6. Thoughts on Verification of Nuclear Disarmament

    Energy Technology Data Exchange (ETDEWEB)

    Dunlop, W H

    2007-09-26

    It is my pleasure to be here to day to participate in this Conference. My thanks to the organizers for preparing such an interesting agenda on a very difficult topic. My effort in preparing my presentation was performed under the auspices of the U.S. Department of Energy by University of California, Lawrence Livermore National Laboratory under Contract W-7405-Eng-48. And as many of you know Lawrence Livermore National Laboratory is now, as of Oct 1st, under contract to the Lawrence Livermore National Security LLC. There has been a long history of how to view verification of arms control agreements. The basis for verification during the days of SALT was that verification would be based on each country's national technical means. For treaties dealing with strategic missiles this worked well as the individual items subject to verification were of such a size that they were visible by the National Technical Means available at the time. And it was felt that the counting of missiles and launchers could be verified by our National Technical Means. For nuclear testing treaties the use of seismic measurements developed into a capability that was reasonably robust for all but the smallest of nuclear tests. However, once we had the Threshold Test Ban Treaty, there was a significant problem in that the fidelity of the measurements were not sufficient to determine if a test was slightly above the 150 kt limit or slightly below the 150 kt limit. This led some in the US to believe that the Soviet Union was not living up to the TTBT agreement. An on-site verification protocol was negotiated in 1988 and 1989 that allowed the US to make hydrodynamic yield measurements on Soviet tests above 50 kt yield and regional seismic measurements on all tests above 35 kt of yield; and the Soviets to make the same type of measurements on US tests to ensure that they were not over 150 kt. These on-site measurements were considered reasonably intrusive. Again the measurement capability was

  7. Replication and Abstraction: Symmetry in Automated Formal Verification

    Directory of Open Access Journals (Sweden)

    Thomas Wahl

    2010-04-01

    Full Text Available This article surveys fundamental and applied aspects of symmetry in system models, and of symmetry reduction methods used to counter state explosion in model checking, an automated formal verification technique. While covering the research field broadly, we particularly emphasize recent progress in applying the technique to realistic systems, including tools that promise to elevate the scope of symmetry reduction to large-scale program verification. The article targets researchers and engineers interested in formal verification of concurrent systems.

  8. Formal Verification of Security Properties in Trust Management Policy

    Science.gov (United States)

    2011-01-01

    Formal Verification of Security Properties in Trust Management Policy ∗ Jianwei Niu William H. Winsborough Mark Reith† University of Texas at San...3. DATES COVERED 00-00-2011 to 00-00-2011 4. TITLE AND SUBTITLE Formal Verification of Security Properties in Trust Management Policy 5a...first step towards formal verification of security policy properties for RBAC. In Proceedings of Fourth International Conference on Quality Software

  9. String-Functional Semantics for Formal Verification of Synchronous Circuits

    Science.gov (United States)

    1988-06-01

    June 1i988 Report No. STAN-CS-88-1210 0 String -Functional Semantics for Formal Verification of Synchronous Circuits 00 by 0 Alexandre Bronstein and...rele~wef Ditribution Uzxliuxted Oa WUN4 P. String-Functional Semantics for Formal Verification of Synchronous Circuits Alexandre Bronstein & Carolyn...Arlington, VA 22209 1 T iTL.E (include Security Classification) String-Functional Semantics for Formal Verification of Synchronous Circuits 𔃼 PERSONA

  10. Testing Equation Method Modification for Demanding Energy Measurements Verification

    Directory of Open Access Journals (Sweden)

    Elena Kochneva

    2016-01-01

    Full Text Available The paper is devoted to the mathematical approaches of the measurements received from Automatic Meter Reading Systems verification. Reliability of metering data can be improved by application of the new issue named Energy Flow Problem. The paper considers demanding energy measurements verification method based on verification expressions groups analysis. Bad data detection and estimates accuracy calculation is presented using the Automatic Meter Reading system data from the Russian power system fragment.

  11. Verification and validation plan for the SFR system analysis module

    Energy Technology Data Exchange (ETDEWEB)

    Hu, R. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2014-12-18

    This report documents the Verification and Validation (V&V) Plan for software verification and validation of the SFR System Analysis Module (SAM), developed at Argonne National Laboratory for sodium fast reactor whole-plant transient analysis. SAM is developed under the DOE NEAMS program and is part of the Reactor Product Line toolkit. The SAM code, the phenomena and computational models of interest, the software quality assurance, and the verification and validation requirements and plans are discussed in this report.

  12. Machine Code Verification of a Tiny ARM Hypervisor

    OpenAIRE

    Dam, Mads; Guanciale, Roberto; Nemati, Hamed

    2013-01-01

    Hypervisors are low level execution platforms that provideisolated partitions on shared resources, allowing to design se-cure systems without using dedicated hardware devices. Akey requirement of this kind of solution is the formal verifi-cation of the software trusted computing base, preferably atthe binary level. We accomplish a detailed verification of anARMv7 tiny hypervisor, proving its correctness at the ma-chine code level. We present our verification strategy, whichmixes the usage of ...

  13. Verification-Based Interval-Passing Algorithm for Compressed Sensing

    OpenAIRE

    Wu, Xiaofu; Yang, Zhen

    2013-01-01

    We propose a verification-based Interval-Passing (IP) algorithm for iteratively reconstruction of nonnegative sparse signals using parity check matrices of low-density parity check (LDPC) codes as measurement matrices. The proposed algorithm can be considered as an improved IP algorithm by further incorporation of the mechanism of verification algorithm. It is proved that the proposed algorithm performs always better than either the IP algorithm or the verification algorithm. Simulation resul...

  14. VERA-CS Verification & Validation Plan

    Energy Technology Data Exchange (ETDEWEB)

    Downar, Thomas [Univ. of Michigan, Ann Arbor, MI (United States)

    2017-02-01

    This report summarizes the current status of VERA-CS Verification and Validation for PWR Core Follow operation and proposes a multi-phase plan for continuing VERA-CS V&V in FY17 and FY18. The proposed plan recognizes the hierarchical nature of a multi-physics code system such as VERA-CS and the importance of first achieving an acceptable level of V&V on each of the single physics codes before focusing on the V&V of the coupled physics solution. The report summarizes the V&V of each of the single physics codes systems currently used for core follow analysis (ie MPACT, CTF, Multigroup Cross Section Generation, and BISON / Fuel Temperature Tables) and proposes specific actions to achieve a uniformly acceptable level of V&V in FY17. The report also recognizes the ongoing development of other codes important for PWR Core Follow (e.g. TIAMAT, MAMBA3D) and proposes Phase II (FY18) VERA-CS V&V activities in which those codes will also reach an acceptable level of V&V. The report then summarizes the current status of VERA-CS multi-physics V&V for PWR Core Follow and the ongoing PWR Core Follow V&V activities for FY17. An automated procedure and output data format is proposed for standardizing the output for core follow calculations and automatically generating tables and figures for the VERA-CS Latex file. A set of acceptance metrics is also proposed for the evaluation and assessment of core follow results that would be used within the script to automatically flag any results which require further analysis or more detailed explanation prior to being added to the VERA-CS validation base. After the Automation Scripts have been completed and tested using BEAVRS, the VERA-CS plan proposes the Watts Bar cycle depletion cases should be performed with the new cross section library and be included in the first draft of the new VERA-CS manual for release at the end of PoR15. Also, within the constraints imposed by the proprietary nature of plant data, as many as possible of the FY17

  15. The concept verification testing of materials science payloads

    Science.gov (United States)

    Griner, C. S.; Johnston, M. H.; Whitaker, A.

    1976-01-01

    The concept Verification Testing (CVT) project at the Marshall Space Flight Center, Alabama, is a developmental activity that supports Shuttle Payload Projects such as Spacelab. It provides an operational 1-g environment for testing NASA and other agency experiment and support systems concepts that may be used in shuttle. A dedicated Materials Science Payload was tested in the General Purpose Laboratory to assess the requirements of a space processing payload on a Spacelab type facility. Physical and functional integration of the experiments into the facility was studied, and the impact of the experiments on the facility (and vice versa) was evaluated. A follow-up test designated CVT Test IVA was also held. The purpose of this test was to repeat Test IV experiments with a crew composed of selected and trained scientists. These personnel were not required to have prior knowledge of the materials science disciplines, but were required to have a basic knowledge of science and the scientific method.

  16. Data storage accounting and verification in LHC experiments

    CERN Document Server

    Ratnikova ,Natalia

    2012-01-01

    All major experiments at Large Hadron Collider (LHC) need to measure real storage usage at the Grid sites. This information is equally important for the resource management, planning, and operations. To verify consistency of the central catalogs, experiments are asking sites to provide full list of files they have on storage, including size, checksum, and other file attributes. Such storage dumps provided at regular intervals give a realistic view of the storage resource usage by the experiments. Regular monitoring of the space usage and data verification serve as additional internal checks of the system integrity and performance. Both the importance and the complexity of these tasks increase with the constant growth of the total data volumes during the active data taking period at the LHC. Developed common solutions help to reduce the maintenance costs both at the large Tier-1 facilities supporting multiple virtual organizations, and at the small sites that often lack manpower. We discuss requirements...

  17. FLITECAM: current status and results from observatory verification flights

    Science.gov (United States)

    McLean, Ian S.; Smith, Erin C.; Becklin, E. E.; Dunham, E. W.; Milburn, Jennifer W.; Savage, Maureen L.

    2012-09-01

    This paper describes the current status of FLITECAM, the near-infrared (1 - 5 μm) camera and spectrometer for NASA's Stratospheric Observatory for Infrared Astronomy (SOFIA). Due to a change in schedule FLITECAM's delivery was advanced, allowing it to be co-mounted with the HIPO instrument and used on four flights in October 2011 for observatory verification. Although not part of FLITECAM's commissioning time, some preliminary performance characteristics were determined. Image size as a function of wavelength was measured prior to the installation of active mass dampers on the telescope. Preliminary grism spectroscopy was also obtained. In addition, FLITECAM was used to measure the emissivity of the telescope and warm optics in the co-mounted configuration. New narrow band filters were added to the instrument, including a Paschen alpha filter for line emission. Results are illustrated.

  18. Verification of Advective Bar Elements Implemented in the Aria Thermal Response Code.

    Energy Technology Data Exchange (ETDEWEB)

    Mills, Brantley [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-01-01

    A verification effort was undertaken to evaluate the implementation of the new advective bar capability in the Aria thermal response code. Several approaches to the verification process were taken : a mesh refinement study to demonstrate solution convergence in the fluid and the solid, visually examining the mapping of the advective bar element nodes to the surrounding surfaces, and a comparison of solutions produced using the advective bars for simple geometries with solutions from commercial CFD software . The mesh refinement study has shown solution convergence for simple pipe flow in both temperature and velocity . Guidelines were provided to achieve appropriate meshes between the advective bar elements and the surrounding volume. Simulations of pipe flow using advective bars elements in Aria have been compared to simulations using the commercial CFD software ANSYS Fluent (r) and provided comparable solutions in temperature and velocity supporting proper implementation of the new capability. Verification of Advective Bar Elements iv Acknowledgements A special thanks goes to Dean Dobranich for his guidance and expertise through all stages of this effort . His advice and feedback was instrumental to its completion. Thanks also goes to Sam Subia and Tolu Okusanya for helping to plan many of the verification activities performed in this document. Thank you to Sam, Justin Lamb and Victor Brunini for their assistance in resolving issues encountered with running the advective bar element model. Finally, thanks goes to Dean, Sam, and Adam Hetzler for reviewing the document and providing very valuable comments.

  19. NEMVP: North American energy measurement and verification protocol

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    This measurement and verification protocol discusses procedures that,when implemented, allow buyers, sellers, and financiers of energy projects to quantify energy conservation measure performance and savings.

  20. An Efficient Location Verification Scheme for Static Wireless Sensor Networks.

    Science.gov (United States)

    Kim, In-Hwan; Kim, Bo-Sung; Song, JooSeok

    2017-01-24

    In wireless sensor networks (WSNs), the accuracy of location information is vital to support many interesting applications. Unfortunately, sensors have difficulty in estimating their location when malicious sensors attack the location estimation process. Even though secure localization schemes have been proposed to protect location estimation process from attacks, they are not enough to eliminate the wrong location estimations in some situations. The location verification can be the solution to the situations or be the second-line defense. The problem of most of the location verifications is the explicit involvement of many sensors in the verification process and requirements, such as special hardware, a dedicated verifier and the trusted third party, which causes more communication and computation overhead. In this paper, we propose an efficient location verification scheme for static WSN called mutually-shared region-based location verification (MSRLV), which reduces those overheads by utilizing the implicit involvement of sensors and eliminating several requirements. In order to achieve this, we use the mutually-shared region between location claimant and verifier for the location verification. The analysis shows that MSRLV reduces communication overhead by 77% and computation overhead by 92% on average, when compared with the other location verification schemes, in a single sensor verification. In addition, simulation results for the verification of the whole network show that MSRLV can detect the malicious sensors by over 90% when sensors in the network have five or more neighbors.

  1. A Synthesized Framework for Formal Verification of Computing Systems

    Directory of Open Access Journals (Sweden)

    Nikola Bogunovic

    2003-12-01

    Full Text Available Design process of computing systems gradually evolved to a level that encompasses formal verification techniques. However, the integration of formal verification techniques into a methodical design procedure has many inherent miscomprehensions and problems. The paper explicates the discrepancy between the real system implementation and the abstracted model that is actually used in the formal verification procedure. Particular attention is paid to the seamless integration of all phases of the verification procedure that encompasses definition of the specification language and denotation and execution of conformance relation between the abstracted model and its intended behavior. The concealed obstacles are exposed, computationally expensive steps identified and possible improvements proposed.

  2. Current status of verification practices in clinical biochemistry in Spain.

    Science.gov (United States)

    Gómez-Rioja, Rubén; Alvarez, Virtudes; Ventura, Montserrat; Alsina, M Jesús; Barba, Núria; Cortés, Mariano; Llopis, María Antonia; Martínez, Cecilia; Ibarz, Mercè

    2013-09-01

    Verification uses logical algorithms to detect potential errors before laboratory results are released to the clinician. Even though verification is one of the main processes in all laboratories, there is a lack of standardization mainly in the algorithms used and the criteria and verification limits applied. A survey in clinical laboratories in Spain was conducted in order to assess the verification process, particularly the use of autoverification. Questionnaires were sent to the laboratories involved in the External Quality Assurance Program organized by the Spanish Society of Clinical Biochemistry and Molecular Pathology. Seven common biochemical parameters were included (glucose, cholesterol, triglycerides, creatinine, potassium, calcium, and alanine aminotransferase). Completed questionnaires were received from 85 laboratories. Nearly all the laboratories reported using the following seven verification criteria: internal quality control, instrument warnings, sample deterioration, reference limits, clinical data, concordance between parameters, and verification of results. The use of all verification criteria varied according to the type of verification (automatic, technical, or medical). Verification limits for these parameters are similar to biological reference ranges. Delta Check was used in 24% of laboratories. Most laboratories (64%) reported using autoverification systems. Autoverification use was related to laboratory size, ownership, and type of laboratory information system, but amount of use (percentage of test autoverified) was not related to laboratory size. A total of 36% of Spanish laboratories do not use autoverification, despite the general implementation of laboratory information systems, most of them, with autoverification ability. Criteria and rules for seven routine biochemical tests were obtained.

  3. Compositional verification of real-time systems using Ecdar

    DEFF Research Database (Denmark)

    David, A.; Larsen, K.G.; Møller, M.H.

    2012-01-01

    We present a specification theory for timed systems implemented in the Ecdar tool. We illustrate the operations of the specification theory on a running example, showing the models and verification checks. To demonstrate the power of the compositional verification, we perform an in depth case study...... of a leader election protocol; Modeling it in Ecdar as Timed input/output automata Specifications and performing both monolithic and compositional verification of two interesting properties on it. We compare the execution time of the compositional to the classical verification showing a huge difference...

  4. SU-E-T-49: A Multi-Institutional Study of Independent Dose Verification for IMRT

    Energy Technology Data Exchange (ETDEWEB)

    Baba, H; Tachibana, H [The National Cancer Center Hospital East, Kashiwa, Chiba (Japan); Kamima, T; Takahashi, R [The Cancer Institute Hospital of JFCR, Koutou-ku, Tokyo (Japan); Kawai, D [Kanagawa Cancer Center, Yokohama, Kanagawa-prefecture (Japan); Sugawara, Y [The National Center for Global Health and Medicine, Shinjuku-ku, Tokyo (Japan); Yamamoto, T [Otemae Hospital, Chuou-ku, Osaka-city (Japan); Sato, A [Itabashi Central General Hospital, Itabashi-ku, Tokyo (Japan); Yamashita, M [Kobe City Medical Center General Hospital, Kobe, Hyogo (Japan)

    2015-06-15

    Purpose: AAPM TG114 does not cover the independent verification for IMRT. We conducted a study of independent dose verification for IMRT in seven institutes to show the feasibility. Methods: 384 IMRT plans in the sites of prostate and head and neck (HN) were collected from the institutes, where the planning was performed using Eclipse and Pinnacle3 with the two techniques of step and shoot (S&S) and sliding window (SW). All of the institutes used a same independent dose verification software program (Simple MU Analysis: SMU, Triangle Product, Ishikawa, JP), which is Clarkson-based and CT images were used to compute radiological path length. An ion-chamber measurement in a water-equivalent slab phantom was performed to compare the doses computed using the TPS and an independent dose verification program. Additionally, the agreement in dose computed in patient CT images between using the TPS and using the SMU was assessed. The dose of the composite beams in the plan was evaluated. Results: The agreement between the measurement and the SMU were −2.3±1.9 % and −5.6±3.6 % for prostate and HN sites, respectively. The agreement between the TPSs and the SMU were −2.1±1.9 % and −3.0±3.7 for prostate and HN sites, respectively. There was a negative systematic difference with similar standard deviation and the difference was larger in the HN site. The S&S technique showed a statistically significant difference between the SW. Because the Clarkson-based method in the independent program underestimated (cannot consider) the dose under the MLC. Conclusion: The accuracy would be improved when the Clarkson-based algorithm should be modified for IMRT and the tolerance level would be within 5%.

  5. Monitoring, reporting and verification for national REDD + programmes: two proposals

    Energy Technology Data Exchange (ETDEWEB)

    Herold, Martin [Center for Geoinformation, Department of Environmental Science, Wageningen University, Droevendaalsesteeg 3, 6708 PB Wageningen (Netherlands); Skutsch, Margaret, E-mail: martin.herold@wur.nl [Centro de Investigaciones en GeografIa Ambiental, UNAM Campus Morelia (Mexico)

    2011-01-15

    Different options have been suggested by Parties to the UNFCCC (United Framework Convention on Climate Change) for inclusion in national approaches to REDD and REDD + (reduced deforestation, reduced degradation, enhancement of forest carbon stocks, sustainable management of forest, and conservation of forest carbon stocks). This paper proposes that from the practical and technical points of view of designing action for REDD and REDD + at local and sub-national level, as well as from the point of view of the necessary MRV (monitoring, reporting and verification), these should be grouped into three categories: conservation, which is rewarded on the basis of no changes in forest stock, reduced deforestation, in which lowered rates of forest area loss are rewarded, and positive impacts on carbon stock changes in forests remaining forest, which includes reduced degradation, sustainable management of forest of various kinds, and forest enhancement. Thus we have moved degradation, which conventionally is grouped with deforestation, into the forest management group reported as areas remaining forest land, with which it has, in reality, and particularly as regards MRV, much more in common. Secondly, in the context of the fact that REDD/REDD + is to take the form of a national or near-national approach, we argue that while systematic national monitoring is important, it may not be necessary for REDD/REDD + activities, or for national MRV, to be started at equal levels of intensity all over the country. Rather, areas where interventions seem easiest to start may be targeted, and here data measurements may be more rigorous (Tier 3), for example based on stakeholder self-monitoring with independent verification, while in other, untreated areas, a lower level of monitoring may be pursued, at least in the first instance. Treated areas may be targeted for any of the three groups of activities (conservation, reduced deforestation, and positive impact on carbon stock increases in

  6. Role of TERRA in the regulation of telomere length.

    Science.gov (United States)

    Wang, Caiqin; Zhao, Li; Lu, Shiming

    2015-01-01

    Telomere dysfunction is closely associated with human diseases such as cancer and ageing. Inappropriate changes in telomere length and/or structure result in telomere dysfunction. Telomeres have been considered to be transcriptionally silent, but it was recently demonstrated that mammalian telomeres are transcribed into telomeric repeat-containing RNA (TERRA). TERRA, a long non-coding RNA, participates in the regulation of telomere length, telomerase activity and heterochromatinization. The correct regulation of telomere length may be crucial to telomeric homeostasis and functions. Here, we summarize recent advances in our understanding of the crucial role of TERRA in the maintenance of telomere length, with focus on the variety of mechanisms by which TERRA is involved in the regulation of telomere length. This review aims to enable further understanding of how TERRA-targeted drugs can target telomere-related diseases.

  7. Environmental Technology Verification Report -- Baghouse filtration products, GE Energy QG061 filtration media ( tested May 2007)

    Science.gov (United States)

    EPA has created the Environmental Technology Verification Program to facilitate the deployment of innovative or improved environmental technologies through performance verification and dissemination of information. The Air Pollution Control Technology Verification Center, a cente...

  8. Verification Challenges of Dynamic Testing of Space Flight Hardware

    Science.gov (United States)

    Winnitoy, Susan

    2010-01-01

    The Six Degree-of-Freedom Dynamic Test System (SDTS) is a test facility at the National Aeronautics and Space Administration (NASA) Johnson Space Center in Houston, Texas for performing dynamic verification of space structures and hardware. Some examples of past and current tests include the verification of on-orbit robotic inspection systems, space vehicle assembly procedures and docking/berthing systems. The facility is able to integrate a dynamic simulation of on-orbit spacecraft mating or demating using flight-like mechanical interface hardware. A force moment sensor is utilized for input to the simulation during the contact phase, thus simulating the contact dynamics. While the verification of flight hardware presents many unique challenges, one particular area of interest is with respect to the use of external measurement systems to ensure accurate feedback of dynamic contact. There are many commercial off-the-shelf (COTS) measurement systems available on the market, and the test facility measurement systems have evolved over time to include two separate COTS systems. The first system incorporates infra-red sensing cameras, while the second system employs a laser interferometer to determine position and orientation data. The specific technical challenges with the measurement systems in a large dynamic environment include changing thermal and humidity levels, operational area and measurement volume, dynamic tracking, and data synchronization. The facility is located in an expansive high-bay area that is occasionally exposed to outside temperature when large retractable doors at each end of the building are opened. The laser interferometer system, in particular, is vulnerable to the environmental changes in the building. The operational area of the test facility itself is sizeable, ranging from seven meters wide and five meters deep to as much as seven meters high. Both facility measurement systems have desirable measurement volumes and the accuracies vary

  9. SU-E-T-455: Impact of Different Independent Dose Verification Software Programs for Secondary Check

    Energy Technology Data Exchange (ETDEWEB)

    Itano, M; Yamazaki, T; Kosaka, M; Kobayashi, N [Inagi Municipal Hospital, Inagi, Tokyo (Japan); Yamashita, M [Kobe City Medical Center General Hospital, Kobe, Hyogo (Japan); Ishibashi, S; Higuchi, Y [Sasebo City General Hospital, Sasebo, Nagasaki (Japan); Tachibana, H [National Cancer Center Hospital East, Kashiwa, Chiba (Japan)

    2015-06-15

    Purpose: There have been many reports for different dose calculation algorithms for treatment planning system (TPS). Independent dose verification program (IndpPro) is essential to verify clinical plans from the TPS. However, the accuracy of different independent dose verification programs was not evident. We conducted a multi-institutional study to reveal the impact of different IndpPros using different TPSs. Methods: Three institutes participated in this study. They used two different IndpPros (RADCALC and Simple MU Analysis (SMU), which implemented the Clarkson algorithm. RADCALC needed the input of radiological path length (RPL) computed by the TPSs (Eclipse or Pinnacle3). SMU used CT images to compute the RPL independently from TPS). An ion-chamber measurement in water-equivalent phantom was performed to evaluate the accuracy of two IndpPros and the TPS in each institute. Next, the accuracy of dose calculation using the two IndpPros compared to TPS was assessed in clinical plan. Results: The accuracy of IndpPros and the TPSs in the homogenous phantom was +/−1% variation to the measurement. 1543 treatment fields were collected from the patients treated in the institutes. The RADCALC showed better accuracy (0.9 ± 2.2 %) than the SMU (1.7 ± 2.1 %). However, the accuracy was dependent on the TPS (Eclipse: 0.5%, Pinnacle3: 1.0%). The accuracy of RADCALC with Eclipse was similar to that of SMU in one of the institute. Conclusion: Depending on independent dose verification program, the accuracy shows systematic dose accuracy variation even though the measurement comparison showed a similar variation. The variation was affected by radiological path length calculation. IndpPro with Pinnacle3 has different variation because Pinnacle3 computed the RPL using physical density. Eclipse and SMU uses electron density, though.

  10. Formal Verification of Large Software Systems

    Science.gov (United States)

    Yin, Xiang; Knight, John

    2010-01-01

    We introduce a scalable proof structure to facilitate formal verification of large software systems. In our approach, we mechanically synthesize an abstract specification from the software implementation, match its static operational structure to that of the original specification, and organize the proof as the conjunction of a series of lemmas about the specification structure. By setting up a different lemma for each distinct element and proving each lemma independently, we obtain the important benefit that the proof scales easily for large systems. We present details of the approach and an illustration of its application on a challenge problem from the security domain

  11. Turf Conversion Measurement and Verification Protocol

    Energy Technology Data Exchange (ETDEWEB)

    Kurnik, Charles W. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Stoughton, Kate M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Figueroa, Jorge [Western Resource Advocates, Boulder, CO (United States)

    2017-12-05

    This measurement and verification (M and V) protocol provides procedures for energy service companies (ESCOs) and water efficiency service companies (WESCOs) to determine water savings as a result of water conservation measures (WCMs) in energy performance contracts associated with converting turfgrass or other water-intensive plantings to water-wise and sustainable landscapes. The water savings are determined by comparing the baseline water use to the water use after the WCM has been implemented. This protocol outlines the basic structure of the M and V plan, and details the procedures to use to determine water savings.

  12. Outdoor Irrigation Measurement and Verification Protocol

    Energy Technology Data Exchange (ETDEWEB)

    Kurnik, Charles W. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Stoughton, Kate M [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Figueroa, Jorge [Western Resource Advocates, Boulder, CO (United States)

    2017-12-05

    This measurement and verification (M&V) protocol provides procedures for energy service companies (ESCOs) and water efficiency service companies (WESCOs) to determine water savings resulting from water conservation measures (WCMs) in energy performance contracts associated with outdoor irrigation efficiency projects. The water savings are determined by comparing the baseline water use to the water use after the WCM has been implemented. This protocol outlines the basic structure of the M&V plan, and details the procedures to use to determine water savings.

  13. Infrared scanner concept verification test report

    Science.gov (United States)

    Bachtel, F. D.

    1980-01-01

    The test results from a concept verification test conducted to assess the use of an infrared scanner as a remote temperature sensing device for the space shuttle program are presented. The temperature and geometric resolution limits, atmospheric attenuation effects including conditions with fog and rain, and the problem of surface emissivity variations are included. It is concluded that the basic concept of using an infrared scanner to determine near freezing surface temperatures is feasible. The major problem identified is concerned with infrared reflections which result in significant errors if not controlled. Action taken to manage these errors result in design and operational constraints to control the viewing angle and surface emissivity.

  14. MODELS CONCERNING PREVENTIVE VERIFICATION OF TECHNICAL EQUIPMENT

    Directory of Open Access Journals (Sweden)

    CÂRLAN M.

    2016-12-01

    Full Text Available The paper presents three operative models whose purpose is to improve the practice of preventive maintenance to a wide range of technical installations. Although the calculation criteria are different, the goal is the same: to determine the optimum time between two consecutive preventive interventions. The optimum criteria of these models are: - the maximum share of technical entity operating probabilities, in the case of the Ackoff - Sasieni [1] method; -the optimum time interval for preventive verification depending on the preventive-corrective maintenance costs imposed by the deciding factor, for the AsturioBaldin [2] model; - the minimum number of renewals – preventive and/or corrective maintenance operations [3

  15. Mesoscale model forecast verification during monsoon 2008

    Indian Academy of Sciences (India)

    Mesoscale model forecast verification during monsoon 2008. 419. Ta b le. 1 . S u mma ry o f th e m od els . T254. W. R. F. M. M5. Eta. H o rizon tal resolution. 0 .5. ◦. ×. 0 .5. ◦. Gau ssian grid. 27 k m. A rak aw. a-C g rid. 90/30/10 k m. A rak aw. a-B g rid. 3. 2 k m. A rak aw a. -E grid. V ertical lev els. 64. 38. 23. 38. T o p ograp h.

  16. State of the Art: Signature Biometrics Verification

    Directory of Open Access Journals (Sweden)

    Nourddine Guersi

    2010-04-01

    Full Text Available This paper presents a comparative analysis of the performance of three estimation algorithms: Expectation Maximization (EM, Greedy EM Algorithm (GEM and Figueiredo-Jain Algorithm (FJ - based on the Gaussian mixture models (GMMs for signature biometrics verification. The simulation results have shown significant performance achievements. The test performance of EER=5.49 % for "EM", EER=5.04 % for "GEM" and EER=5.00 % for "FJ", shows that the behavioral information scheme of signature biometrics is robust and has a discriminating power, which can be explored for identity authentication.

  17. Formal Specification and Verification of Distributed System.

    Science.gov (United States)

    1983-06-01

    a->b); A distributed design [HOA78] to generate prime numbers using the " sieve of Eratosthenes " method, is depicted in Figure 11. PNG consists of two... Sieve . 22 5.4.1.2 The Printer. 23 5.4.2 The Verification of PNG. 23 6. Conclusions and Comparisons to Other Approaches ..............25 6.1 The Temporal...types of processes: sieves and a printer. To simplify the description, assume there are infinite number of sieve processes, denoted by Sieve [l], Sieve

  18. FEFTRA {sup TM} verification. Update 2013

    Energy Technology Data Exchange (ETDEWEB)

    Loefman, J. [VTT Technical Research Centre of Finland, Espoo (Finland); Meszaros, F. [The Relief Lab., Harskut, (Hungary)

    2013-12-15

    FEFTRA is a finite element program package developed at VTT for the analyses of groundwater flow in Posiva's site evaluation programme that seeks a final repository for spent nuclear fuel in Finland. The code is capable of modelling steady-state or transient groundwater flow, solute transport and heat transfer as coupled or separate phenomena. Being a typical research tool used only by its developers, the FEFTRA code lacked long of a competent testing system and precise documentation of the verification of the code. In 2006 a project was launched, in which the objective was to reorganise all the material related to the existing verification cases and place them into the FEFTRA program path under the version-control system. The work also included development of a new testing system, which automatically calculates the selected cases, checks the new results against the old approved results and constructs a summary of the test run. All the existing cases were gathered together, checked and added into the new testing system. The documentation of each case was rewritten with the LATEX document preparation system and added into the testing system in a way that the whole test documentation (this report) could easily be generated in a postscript or pdf-format. The current report is the updated version of the verification report published in 2007. At the moment the report includes mainly the cases related to the testing of the primary result quantities (i.e. hydraulic head, pressure, salinity concentration, temperature). The selected cases, however, represent typical hydrological applications, in which the program package has been and will be employed in the Posiva's site evaluation programme, i.e. the simulations of groundwater flow, solute transport and heat transfer as separate or coupled phenomena. The comparison of the FEFTRA results to the analytical, semianalytical and/or other numerical solutions proves the capability of FEFTRA to simulate such problems

  19. Stamp Verification for Automated Document Authentication

    DEFF Research Database (Denmark)

    Micenková, Barbora; van Beusekom, Joost; Shafait, Faisal

    Stamps, along with signatures, can be considered as the most widely used extrinsic security feature in paper documents. In contrast to signatures, however, for stamps little work has been done to automatically verify their authenticity. In this paper, an approach for verification of color stamps...... is presented. We focus on photocopied stamps as non-genuine stamps. Our previously presented stamp detection method is improved and extended to verify that the stamp is genuine and not a copy. Using a variety of features, a classifier is trained that allows successful separation between genuine stamps...

  20. Predicting SMT Solver Performance for Software Verification

    Directory of Open Access Journals (Sweden)

    Andrew Healy

    2017-01-01

    Full Text Available The Why3 IDE and verification system facilitates the use of a wide range of Satisfiability Modulo Theories (SMT solvers through a driver-based architecture. We present Where4: a portfolio-based approach to discharge Why3 proof obligations. We use data analysis and machine learning techniques on static metrics derived from program source code. Our approach benefits software engineers by providing a single utility to delegate proof obligations to the solvers most likely to return a useful result. It does this in a time-efficient way using existing Why3 and solver installations - without requiring low-level knowledge about SMT solver operation from the user.

  1. Scaling Analysis of the Screening Length in Concentrated Electrolytes

    Science.gov (United States)

    Lee, Alpha A.; Perez-Martinez, Carla S.; Smith, Alexander M.; Perkin, Susan

    2017-07-01

    The interaction between charged objects in an electrolyte solution is a fundamental question in soft matter physics. It is well known that the electrostatic contribution to the interaction energy decays exponentially with object separation. Recent measurements reveal that, contrary to the conventional wisdom given by the classic Poisson-Boltzmann theory, the decay length increases with the ion concentration for concentrated electrolytes and can be an order of magnitude larger than the ion diameter in ionic liquids. We derive a simple scaling theory that explains this anomalous dependence of the decay length on the ion concentration. Our theory successfully collapses the decay lengths of a wide class of salts onto a single curve. A novel prediction of our theory is that the decay length increases linearly with the Bjerrum length, which we experimentally verify by surface force measurements. Moreover, we quantitatively relate the measured decay length to classic measurements of the activity coefficient in concentrated electrolytes, thus showing that the measured decay length is indeed a bulk property of the concentrated electrolyte as well as contributing a mechanistic insight into empirical activity coefficients.

  2. The yeast VPS genes affect telomere length regulation.

    Science.gov (United States)

    Rog, Ofer; Smolikov, Sarit; Krauskopf, Anat; Kupiec, Martin

    2005-01-01

    Eukaryotic cells invest a large proportion of their genome in maintaining telomere length homeostasis. Among the 173 non-essential yeast genes found to affect telomere length, a large proportion is involved in vacuolar traffic. When mutated, these vacuolar protein-sorting (VPS) genes lead to telomeres shorter than those observed in the wild type. Using genetic analysis, we characterized the pathway by which VPS15, VPS34, VPS22, VPS23 and VPS28 affect the telomeres. Our results indicate that these VPS genes affect telomere length through a single pathway and that this effect requires the activity of telomerase and the Ku heterodimer, but not the activity of Tel1p or Rif2p. We present models to explain the link between vacuolar traffic and telomere length homeostasis.

  3. Arc Length of a Pipe Needed for a Directional Drill

    Directory of Open Access Journals (Sweden)

    Kenneth Cabana

    2011-01-01

    Full Text Available Underground contracting has come a long way in recent years. As communities and buildings are being built, services like water, sewer, and gas are needed to allow people to perform their day to day activities. This research has led to the idea and design of a way to find the arc length of the pipe put into the ground at given points. The pipe length was estimated using the formulas for distance and arc length together with two different modeling methods: Lagrange interpolation and polynomial regression. Both techniques yielded similar results; however this may be situational and in other circumstances their effectiveness may vary.

  4. Geometry of area without length

    Science.gov (United States)

    Ho, Pei-Ming; Inami, Takeo

    2016-01-01

    To define a free string by the Nambu-Goto action, all we need is the notion of area, and mathematically the area can be defined directly in the absence of a metric. Motivated by the possibility that string theory admits backgrounds where the notion of length is not well defined but a definition of area is given, we study space-time geometries based on the generalization of a metric to an area metric. In analogy with Riemannian geometry, we define the analogues of connections, curvatures, and Einstein tensor. We propose a formulation generalizing Einstein's theory that will be useful if at a certain stage or a certain scale the metric is ill defined and the space-time is better characterized by the notion of area. Static spherical solutions are found for the generalized Einstein equation in vacuum, including the Schwarzschild solution as a special case.

  5. First Images from VLT Science Verification Programme

    Science.gov (United States)

    1998-09-01

    Two Weeks of Intensive Observations Successfully Concluded After a period of technical commissioning tests, the first 8.2-m telescope of the ESO VLT (UT1) has successfully performed an extensive series of "real science" observations , yielding nearly 100 hours of precious data. They concern all possible types of astronomical objects, from distant galaxies and quasars to pulsars, star clusters and solar system objects. This intensive Science Verification (SV) Programme took place as planned from August 17 to September 1, 1998, and was conducted by the ESO SV Team at the VLT Observatory on Paranal (Chile) and at the ESO Headquarters in Garching (Germany). The new giant telescope lived fully up to the high expectations and worked with spectacular efficiency and performance through the entire period. All data will be released by September 30 via the VLT archive and the web (with some access restrictions - see below). The Science Verification period Just before the beginning of the SV period, the 8.2-m primary mirror in its cell was temporarily removed in order to install the "M3 tower" with the tertiary mirror [1]. The reassembly began on August 15 and included re-installation at the Cassegrain focus of the VLT Test Camera that was also used for the "First Light" images in May 1998. After careful optical alignment and various system tests, the UT1 was handed over to the SV Team on August 17 at midnight local time. The first SV observations began immediately thereafter and the SV Team was active 24 hours a day throughout the two-week period. Video-conferences between Garching and Paranal took place every day at about noon Garching time (6 o'clock in the morning on Paranal). Then, while the Paranal observers were sleeping, data from the previous night were inspected and reduced in Garching, with feedback on what was best to do during the following night being emailed to Paranal several hours in advance of the beginning of the observations. The campaign ended in the

  6. The new geospatial tools: global transparency enhancing safeguards verification

    Energy Technology Data Exchange (ETDEWEB)

    Pabian, Frank Vincent [Los Alamos National Laboratory

    2010-09-16

    This paper focuses on the importance and potential role of the new, freely available, geospatial tools for enhancing IAEA safeguards and how, together with commercial satellite imagery, they can be used to promote 'all-source synergy'. As additional 'open sources', these new geospatial tools have heralded a new era of 'global transparency' and they can be used to substantially augment existing information-driven safeguards gathering techniques, procedures, and analyses in the remote detection of undeclared facilities, as well as support ongoing monitoring and verification of various treaty (e.g., NPT, FMCT) relevant activities and programs. As an illustration of how these new geospatial tools may be applied, an original exemplar case study provides how it is possible to derive value-added follow-up information on some recent public media reporting of a former clandestine underground plutonium production complex (now being converted to a 'Tourist Attraction' given the site's abandonment by China in the early 1980s). That open source media reporting, when combined with subsequent commentary found in various Internet-based Blogs and Wikis, led to independent verification of the reporting with additional ground truth via 'crowdsourcing' (tourist photos as found on 'social networking' venues like Google Earth's Panoramio layer and Twitter). Confirmation of the precise geospatial location of the site (along with a more complete facility characterization incorporating 3-D Modeling and visualization) was only made possible following the acquisition of higher resolution commercial satellite imagery that could be correlated with the reporting, ground photos, and an interior diagram, through original imagery analysis of the overhead imagery.

  7. Mapping {sup 15}O Production Rate for Proton Therapy Verification

    Energy Technology Data Exchange (ETDEWEB)

    Grogg, Kira; Alpert, Nathaniel M.; Zhu, Xuping [Center for Advanced Radiological Sciences, Nuclear Medicine and Molecular Imaging, Radiology Department, Massachusetts General Hospital, Boston, Massachusetts (United States); Min, Chul Hee [Department of Radiological Science, College of Health Science, Yonsei University, Wonju, Kangwon (Korea, Republic of); Testa, Mauro; Winey, Brian [Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (United States); Normandin, Marc D. [Center for Advanced Radiological Sciences, Nuclear Medicine and Molecular Imaging, Radiology Department, Massachusetts General Hospital, Boston, Massachusetts (United States); Shih, Helen A.; Paganetti, Harald; Bortfeld, Thomas [Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (United States); El Fakhri, Georges, E-mail: elfakhri@pet.mgh.harvard.edu [Center for Advanced Radiological Sciences, Nuclear Medicine and Molecular Imaging, Radiology Department, Massachusetts General Hospital, Boston, Massachusetts (United States)

    2015-06-01

    Purpose: This work was a proof-of-principle study for the evaluation of oxygen-15 ({sup 15}O) production as an imaging target through the use of positron emission tomography (PET), to improve verification of proton treatment plans and to study the effects of perfusion. Methods and Materials: Dynamic PET measurements of irradiation-produced isotopes were made for a phantom and rabbit thigh muscles. The rabbit muscle was irradiated and imaged under both live and dead conditions. A differential equation was fitted to phantom and in vivo data, yielding estimates of {sup 15}O production and clearance rates, which were compared to live versus dead rates for the rabbit and to Monte Carlo predictions. Results: PET clearance rates agreed with decay constants of the dominant radionuclide species in 3 different phantom materials. In 2 oxygen-rich materials, the ratio of {sup 15}O production rates agreed with the expected ratio. In the dead rabbit thighs, the dynamic PET concentration histories were accurately described using {sup 15}O decay constant, whereas the live thigh activity decayed faster. Most importantly, the {sup 15}O production rates agreed within 2% (P>.5) between conditions. Conclusions: We developed a new method for quantitative measurement of {sup 15}O production and clearance rates in the period immediately following proton therapy. Measurements in the phantom and rabbits were well described in terms of {sup 15}O production and clearance rates, plus a correction for other isotopes. These proof-of-principle results support the feasibility of detailed verification of proton therapy treatment delivery. In addition, {sup 15}O clearance rates may be useful in monitoring permeability changes due to therapy.

  8. Formal Verification of Security Properties of Privacy Enhanced Mail

    Science.gov (United States)

    1998-06-01

    AFRL-IF-RS-TR-1998-99 Final Technical Report June 1998 FORMAL VERIFICATION OF SECURITY PROPERTIES OF PRIVACY ENHANCED MAIL Syracuse University...AND DATES COVERED Final Jun 96 - Jul 97 4. TITLE AND SUBTITLE FORMAL VERIFICATION OF SECURITY PROPERTIES OF PRIVACY ENHANCED MAIL 6. AUTHOR

  9. 24 CFR 960.259 - Family information and verification.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Family information and verification... information and verification. (a) Family obligation to supply information. (1) The family must supply any information that the PHA or HUD determines is necessary in administration of the public housing program...

  10. 10 CFR 60.47 - Facility information and verification.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Facility information and verification. 60.47 Section 60.47... REPOSITORIES Licenses Us/iaea Safeguards Agreement § 60.47 Facility information and verification. (a) In... and each recipient of a construction authorization or a license shall submit facility information, as...

  11. 10 CFR 72.79 - Facility information and verification.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Facility information and verification. 72.79 Section 72.79..., Reports, Inspections, and Enforcement § 72.79 Facility information and verification. (a) In response to a... recipient of a certificate of compliance or specific or general license shall submit facility information...

  12. 10 CFR 61.32 - Facility information and verification.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Facility information and verification. 61.32 Section 61.32... WASTE Licenses Us/iaea Safeguards Agreement § 61.32 Facility information and verification. (a) In... license shall submit facility information, as described in § 75.10 of this chapter, on Form N-71 and...

  13. 24 CFR 5.659 - Family information and verification.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Family information and verification... § 5.659 Family information and verification. (a) Applicability. This section states requirements for... obligation to supply information. (1) The family must supply any information that HUD or the owner determines...

  14. 28 CFR 811.9 - Periodic verification of registration information.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Periodic verification of registration information. 811.9 Section 811.9 Judicial Administration COURT SERVICES AND OFFENDER SUPERVISION AGENCY FOR THE DISTRICT OF COLUMBIA SEX OFFENDER REGISTRATION § 811.9 Periodic verification of registration...

  15. Improving a Modular Verification Technique for Aspect Oriented Programming

    NARCIS (Netherlands)

    Laarman, Alfons; Huijs, C.

    2006-01-01

    As aspect oriented software becomes more popular, there will be more demand for a method of verifying the correctness of the programs. This paper tries to address the verification issue by improving a modular verification technique proposed by Krisnamuhrti et al. The technique has the problem that

  16. 10 CFR 50.78 - Facility information and verification.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Facility information and verification. 50.78 Section 50.78... Safeguards Agreement § 50.78 Facility information and verification. (a) In response to a written request by... construction permit or a license shall submit facility information, as described in § 75.10 of this chapter, on...

  17. 10 CFR 63.47 - Facility information and verification.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Facility information and verification. 63.47 Section 63.47... REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses Us/iaea Safeguards Agreement § 63.47 Facility information and verification. (a) In response to a written request by the Commission, each applicant for a construction...

  18. 19 CFR 181.73 - Notification of verification visit.

    Science.gov (United States)

    2010-04-01

    ... conducting a verification visit in Canada or Mexico pursuant to § 181.72(a)(2)(iii) of this part, Customs... 19 Customs Duties 2 2010-04-01 2010-04-01 false Notification of verification visit. 181.73 Section 181.73 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT...

  19. 25 CFR 39.405 - How will verifications be conducted?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How will verifications be conducted? 39.405 Section 39... EQUALIZATION PROGRAM Accountability § 39.405 How will verifications be conducted? The eligibility of every student shall be verified. The ELO will take a random sampling of five days with a minimum of one day per...

  20. Orbit attitude processor. STS-1 bench program verification test plan

    Science.gov (United States)

    Mcclain, C. R.

    1980-01-01

    A plan for the static verification of the STS-1 ATT PROC ORBIT software requirements is presented. The orbit version of the SAPIENS bench program is used to generate the verification data. A brief discussion of the simulation software and flight software modules is presented along with a description of the test cases.