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Sample records for active episomal hat

  1. Antioxidant Activity/Capacity Measurement. 2. Hydrogen Atom Transfer (HAT)-Based, Mixed-Mode (Electron Transfer (ET)/HAT), and Lipid Peroxidation Assays.

    Science.gov (United States)

    Apak, Reşat; Özyürek, Mustafa; Güçlü, Kubilay; Çapanoğlu, Esra

    2016-02-10

    Measuring the antioxidant activity/capacity levels of food extracts and biological fluids is useful for determining the nutritional value of foodstuffs and for the diagnosis, treatment, and follow-up of numerous oxidative stress-related diseases. Biologically, antioxidants play their health-beneficial roles via transferring a hydrogen (H) atom or an electron (e(-)) to reactive species, thereby deactivating them. Antioxidant activity assays imitate this action; that is, antioxidants are measured by their H atom transfer (HAT) or e(-) transfer (ET) to probe molecules. Antioxidant activity/capacity can be monitored by a wide variety of assays with different mechanisms, including HAT, ET, and mixed-mode (ET/HAT) assays, generally without distinct boundaries between them. Understanding the principal mechanisms, advantages, and disadvantages of the measurement assays is important for proper selection of method for valid evaluation of antioxidant properties in desired applications. This work provides a general and up-to-date overview of HAT-based, mixed-mode (ET/HAT), and lipid peroxidation assays available for measuring antioxidant activity/capacity and the chemistry behind them, including a critical evaluation of their advantages and drawbacks. PMID:26805392

  2. Antioxidant Activity/Capacity Measurement. 2. Hydrogen Atom Transfer (HAT)-Based, Mixed-Mode (Electron Transfer (ET)/HAT), and Lipid Peroxidation Assays.

    Science.gov (United States)

    Apak, Reşat; Özyürek, Mustafa; Güçlü, Kubilay; Çapanoğlu, Esra

    2016-02-10

    Measuring the antioxidant activity/capacity levels of food extracts and biological fluids is useful for determining the nutritional value of foodstuffs and for the diagnosis, treatment, and follow-up of numerous oxidative stress-related diseases. Biologically, antioxidants play their health-beneficial roles via transferring a hydrogen (H) atom or an electron (e(-)) to reactive species, thereby deactivating them. Antioxidant activity assays imitate this action; that is, antioxidants are measured by their H atom transfer (HAT) or e(-) transfer (ET) to probe molecules. Antioxidant activity/capacity can be monitored by a wide variety of assays with different mechanisms, including HAT, ET, and mixed-mode (ET/HAT) assays, generally without distinct boundaries between them. Understanding the principal mechanisms, advantages, and disadvantages of the measurement assays is important for proper selection of method for valid evaluation of antioxidant properties in desired applications. This work provides a general and up-to-date overview of HAT-based, mixed-mode (ET/HAT), and lipid peroxidation assays available for measuring antioxidant activity/capacity and the chemistry behind them, including a critical evaluation of their advantages and drawbacks.

  3. HAT activity is essential for CBP-1-dependent transcription and differentiation in Caenorhabditis elegans

    OpenAIRE

    Victor, Martin; Bei, Yanxia; Gay, Frédérique; Calvo, Dominica; Mello, Craig; Shi, Yang

    2002-01-01

    The p300/CBP family of transcriptional coactivators possesses multiple functional domains, including a histone acetyltransferase (HAT) and several activation domains. A number of models have been proposed to account for their roles in transcriptional activation, including interactions with basal transcription machinery and chromatin remodeling. However, individual contributions of these domains to transcriptional activation and their significance in living organisms remain unclear. We address...

  4. HATS-2b: A transiting extrasolar planet orbiting a K-type star showing starspot activity

    CERN Document Server

    Mohler-Fischer, M; Hartman, J D; Bakos, G B; Penev, K; Bayliss, D; Jordan, A; Csubry, Z; Zhou, G; Rabus, M; Nikolov, N; Brahm, R; Espinoza, N; Buchhave, L A; Beky, B; Suc, V; Csak, B; Henning, T; Wright, D J; Tinney, C G; Addison, B C; Schmidt, B; Noyes, R W; Papp, I; Lazar, J; Sari, P; Conroy, P

    2013-01-01

    We report the discovery of HATS-2b, the second transiting extrasolar planet detected by the HATSouth survey. HATS-2b is moving on a circular orbit around a V=13.6 mag, K-type dwarf star (GSC 6665-00236), at a separation of 0.0230 \\pm 0.0003 AU and with a period of 1.3541 days. The planetary parameters have been robustly determined using a simultaneous fit of the HATSouth, MPG/ESO~2.2\\,m/GROND, Faulkes Telescope South/Spectral transit photometry and MPG/ESO~2.2\\,m/FEROS, Euler~1.2\\,m/CORALIE, AAT~3.9\\,m/CYCLOPS radial-velocity measurements. HATS-2b has a mass of 1.37 \\pm 0.16 M_J, a radius of 1.14 \\pm 0.03 R_J and an equilibrium temperature of 1567 \\pm 30 K. The host star has a mass of 0.88 \\pm 0.04 M_Sun, radius of 0.89 \\pm 0.02 R_Sun and shows starspot activity. We characterized the stellar activity by analysing two photometric follow-up transit light curves taken with the GROND instrument, both obtained simultaneously in four optical bands (covering the wavelength range of 3860-9520 \\AA). The two light curv...

  5. Imbalance between HAT and HDAC activities in the PBMCs of patients with ankylosing spondylitis or rheumatoid arthritis and influence of HDAC inhibitors on TNF alpha production.

    Directory of Open Access Journals (Sweden)

    Eric Toussirot

    Full Text Available OBJECTIVE: Acetylation or deacetylation of histone proteins may modulate cytokine gene transcription such as TNF alpha (TNF. We evaluated the balance between histone deacetytlase (HDAC and histone acetyltransferase (HAT in patients with rheumatoid arthritis (RA or ankylosing spondylitis (AS compared to healthy controls (HC and determined the influence of HDAC inhibitors (trichostatin A -TSA- or Sirtinol -Sirt- on these enzymatic activities and on the PBMC production of TNF. METHODS: 52 patients with RA, 21 with AS and 38 HC were evaluated. HAT and HDAC activities were measured on nuclear extracts from PBMC using colorimetric assays. Enzymatic activities were determined prior to and after ex vivo treatment of PBMC by TSA or Sirt. TNF levels were evaluated in PBMC culture supernatants in the absence or presence of TSA or Sirt. RESULTS: HAT and HDAC activities were significantly reduced in AS, while these activities reached similar levels in RA and HC. Ex vivo treatment of PBMC by HDACi tended to decrease HDAC expression in HC, but Sirt significantly reduced HAT in RA. TNF production by PBMC was significantly down-regulated by Sirt in HC and AS patients. CONCLUSION: HAT and HDAC were disturbed in AS while no major changes were found in RA. HDACi may modulate HDAC and HAT PBMC expression, especially Sirt in RA. Sirtinol was able to down regulate TNF production by PBMC in HC and AS. An imbalance between HAT and HDAC activities might provide the rationale for the development of HDACi in the therapeutic approach to inflammatory rheumatic diseases.

  6. TCUP: A novel hAT transposon active in maize tissue culture

    Directory of Open Access Journals (Sweden)

    Alan eSmith

    2012-01-01

    Full Text Available Transposable elements are capable of inducing heritable de novo genetic variation. The sequences capable of reactivation, and environmental factors that induce mobilization, remain poorly defined even in well-studied genomes such as maize. We treated maize tissue culture with the demethylating agent 5-aza-2-deoxcytidine and examined long-term tissue culture lines to discover silenced transposable elements that have the potential to induce heritable genetic variation. Through these screens we have identified a novel low copy number hAT transposon, Tissue Culture Up-Regulated (TCUP, which is transcribed at high levels in long-term maize Black Mexican Sweet (BMS tissue culture and up-regulated in response to treatment with 5-aza-2-deoxycytidine. Analysis of the TIGR Maize Gene Index revealed that this element is the most frequently represented EST from the BMS cell culture library and is not represented in other tissue libraries, which is the basis for its name. A full-length sequence was assembled in inbred B73 that contains the putative functional motifs required for autonomous movement of a hAT transposon. Transposon display detected movement of TCUP in two long-term tissue cultured cell lines of the genotype Hi-II AxB and BMS. This research implicates TCUP as a transposon that is capable of reactivation and which may also be particularly sensitive to the stress of the tissue culture environment. Our findings are consistent with the hypothesis that epigenetic alterations potentiate genomic responses to stress during clonal propagation of plants.

  7. Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts.

    Directory of Open Access Journals (Sweden)

    Stephanie Bertram

    Full Text Available The type II transmembrane serine proteases TMPRSS2 and HAT activate influenza viruses and the SARS-coronavirus (TMPRSS2 in cell culture and may play an important role in viral spread and pathogenesis in the infected host. However, it is at present largely unclear to what extent these proteases are expressed in viral target cells in human tissues. Here, we show that both HAT and TMPRSS2 are coexpressed with 2,6-linked sialic acids, the major receptor determinant of human influenza viruses, throughout the human respiratory tract. Similarly, coexpression of ACE2, the SARS-coronavirus receptor, and TMPRSS2 was frequently found in the upper and lower aerodigestive tract, with the exception of the vocal folds, epiglottis and trachea. Finally, activation of influenza virus was conserved between human, avian and porcine TMPRSS2, suggesting that this protease might activate influenza virus in reservoir-, intermediate- and human hosts. In sum, our results show that TMPRSS2 and HAT are expressed by important influenza and SARS-coronavirus target cells and could thus support viral spread in the human host.

  8. Association with the origin recognition complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p

    Directory of Open Access Journals (Sweden)

    Greenblatt Jack F

    2007-09-01

    Full Text Available Abstract Background Histone modifications have been implicated in the regulation of transcription and, more recently, in DNA replication and repair. In yeast, a major conserved histone acetyltransferase, Hat1p, preferentially acetylates lysine residues 5 and 12 on histone H4. Results Here, we report that a nuclear sub-complex consisting of Hat1p and its partner Hat2p interacts physically and functionally with the origin recognition complex (ORC. While mutational inactivation of the histone acetyltransferase (HAT gene HAT1 alone does not compromise origin firing or initiation of DNA replication, a deletion in HAT1 (or HAT2 exacerbates the growth defects of conditional orc-ts mutants. Thus, the ORC-associated Hat1p-dependent histone acetyltransferase activity suggests a novel linkage between histone modification and DNA replication. Additional genetic and biochemical evidence points to the existence of partly overlapping histone H3 acetyltransferase activities in addition to Hat1p/Hat2p for proper DNA replication efficiency. Furthermore, we demonstrated a dynamic association of Hat1p with chromatin during S-phase that suggests a role of this enzyme at the replication fork. Conclusion We have found an intriguing new association of the Hat1p-dependent histone acetyltransferase in addition to its previously known role in nuclear chromatin assembly (Hat1p/Hat2p-Hif1p. The participation of a distinct Hat1p/Hat2p sub-complex suggests a linkage of histone H4 modification with ORC-dependent DNA replication.

  9. MAR characteristic motifs mediate episomal vector in CHO cells.

    Science.gov (United States)

    Lin, Yan; Li, Zhaoxi; Wang, Tianyun; Wang, Xiaoyin; Wang, Li; Dong, Weihua; Jing, Changqin; Yang, Xianjun

    2015-04-01

    An ideal gene therapy vector should enable persistent transgene expression without limitations in safety and reproducibility. Recent researches' insight into the ability of chromosomal matrix attachment regions (MARs) to mediate episomal maintenance of genetic elements allowed the development of a circular episomal vector. Although a MAR-mediated engineered vector has been developed, little is known on which motifs of MAR confer this function during interaction with the host genome. Here, we report an artificially synthesized DNA fragment containing only characteristic motif sequences that served as an alternative to human beta-interferon matrix attachment region sequence. The potential of the vector to mediate gene transfer in CHO cells was investigated. The short synthetic MAR motifs were found to mediate episomal vector at a low copy number for many generations without integration into the host genome. Higher transgene expression was maintained for at least 4 months. In addition, MAR was maintained episomally and conferred sustained EGFP expression even in nonselective CHO cells. All the results demonstrated that MAR characteristic sequence-based vector can function as stable episomes in CHO cells, supporting long-term and effective transgene expression.

  10. Program Transformation in HATS

    Energy Technology Data Exchange (ETDEWEB)

    Winter, V.L.

    1999-02-24

    HATS is a general purpose syntax derivation tree based transformation system in which transformation sequences are described in special purpose language. A powerful feature of this language is that unification is an explicit operation. By making unification explicit, an elegant framework arises in which to express complex application conditions which in turn enables refined control strategies to be realized. This paper gives an overview of HATS, focusing especially on the framework provided by the transformation language and its potential with respect to control and general purpose transformation.

  11. Hard-hat day

    CERN Multimedia

    2003-01-01

    CERN will be organizing a special information day on Friday, 27th June, designed to promote the wearing of hard hats and ensure that they are worn correctly. A new prevention campaign will also be launched.The event will take place in the hall of the Main Building from 11.30 a.m. to 2.00 p.m., when you will be able to come and try on various models of hard hat, including some of the very latest innovative designs, ask questions and pass on any comments and suggestions.

  12. A role for MRE11, NBS1, and recombination junctions in replication and stable maintenance of EBV episomes.

    Directory of Open Access Journals (Sweden)

    Jayaraju Dheekollu

    Full Text Available Recombination-like structures formed at origins of DNA replication may contribute to replication fidelity, sister chromatid cohesion, chromosome segregation, and overall genome stability. The Epstein-Barr Virus (EBV origin of plasmid replication (OriP provides episomal genome stability through a poorly understood mechanism. We show here that recombinational repair proteins MRE11 and NBS1 are recruited to the Dyad Symmetry (DS region of OriP in a TRF2- and cell cycle-dependent manner. Depletion of MRE11 or NBS1 by siRNA inhibits OriP replication and destabilized viral episomes. OriP plasmid maintenance was defective in MRE11 and NBS1 hypomorphic fibroblast cell lines and only integrated, non-episomal forms of EBV were detected in a lympoblastoid cell line derived from an NBS1-mutated individual. Two-dimensional agarose gel analysis of OriP DNA revealed that recombination-like structures resembling Holliday-junctions form at OriP in mid S phase. MRE11 and NBS1 association with DS coincided with replication fork pausing and origin activation, which preceded the formation of recombination structures. We propose that NBS1 and MRE11 promote replication-associated recombination junctions essential for EBV episomal maintenance and genome stability.

  13. Monitoring glaciers and indications of subglacial volcanic activity using small-scale Top-Hat reflectors - An IsViews experiment on Myrdalsjökull, Iceland

    Science.gov (United States)

    Minet, Christian; Duque Biarge, Sergi; Jaenicke, Julia; Münzer, Ulrich; Mayer, Christoph; Franke, Jonas; Guðmundsson, Águst; Parizzi, Alessandro; Fritz, Thomas; Eineder, Michael

    2014-05-01

    Subglacial volcanic eruptions often provide indications of activity some time before the actual catastrophic event. Surface undulations appear on top of the ice cap and meltwater torrents can occur at the glacier margin. Even large scale uplifts of ice caps have been observed. Within the project IsViews a processing chain, based on high spatially and temporally resolved remote sensing imagery, will be developed in order to automatically identify such early indications. The main data used for this analysis are acquired by the TerraSAR-X, TanDEM-X and RapidEye satellites. First investigations concerning the feasibility of the near real-time warning system and the general baseline conditions are carried out on two large plateau glaciers in southern Iceland, namely Mördalsjökull and Vatnajökull. Within the 2013 IsViews field work an experiment was started in order to test a new way of glacier monitoring. Two test sites were established on the Mördalsjökull ice cap (one at the equilibrium line and one below), each consisting of a permanent GPS station and two nearby RADAR reflectors. These RADAR reflectors are specially designed Top-Hat reflectors, which are cheap to manufacture, small (50 cm diameter) and lightweight and therefore easy to handle, transport and deploy. Their special design makes them visible in SAR images independent of orientation, so different acquisition geometries and even different sensors can be used. The drawback of the small, low reflecting Top-Hat can be overcome by using the newly implemented Staring Spotlight Mode of the German SAR Satellite TerraSAR-X, providing an unprecedented resolution of down to 20 cm in the azimuth direction. The reflectors, as point targets, allow absolute positioning within the cm-level in the TerraSAR-X data. Time series of SAR data can be used to derive position and altitude changes of the reflector itself and possibly even melting rates by exploiting the different signal paths. The visibility of the Top-Hat

  14. Histone acetyltransferase (HAT) activity of p300 modulates human T lymphotropic virus type 1 p30II-mediated repression of LTR transcriptional activity

    International Nuclear Information System (INIS)

    Human T-lymphotropic virus type-1 (HTLV-1) is a deltaretrovirus that causes adult T cell leukemia/lymphoma, and is implicated in a variety of lymphocyte-mediated inflammatory disorders. HTLV-1 provirus has regulatory and accessory genes in four pX open reading frames. HTLV-1 pX ORF-II encodes two proteins, p13II and p30II, which are incompletely defined in virus replication or pathogenesis. We have demonstrated that pX ORF-II mutations block virus replication in vivo and that ORF-II encoded p30II, a nuclear-localizing protein that binds with CREB-binding protein (CBP)/p300, represses CREB and Tax responsive element (TRE)-mediated transcription. Herein, we have identified p30II motifs important for p300 binding and in regulating TRE-mediated transcription in the absence and presence of HTLV-1 provirus. Within amino acids 100-179 of p30II, a region important for repression of LTR-mediated transcription, we identified a single lysine residue at amino acid 106 (K3) that significantly modulates the ability of p30II to repress TRE-mediated transcription. Exogenous p300, in a dose-responsive manner, reverses p30II-dependent repression of TRE-mediated transcription, in the absence or presence of the provirus, In contrast to wild type p300, p300 HAT mutants (defective in histone acetyltransferase activity) only partially rescued p30II-mediated LTR repression. Deacetylation by histone deacetylase-1 (HDAC-1) enhanced p30II-mediated LTR repression, while inhibition of deacetylation by trichostatin A decreases p30II-mediated LTR repression. Collectively, our data indicate that HTLV-1 p30II modulates viral gene expression in a cooperative manner with p300-mediated acetylation

  15. HATS-15 b and HATS-16 b: Two massive planets transiting old G dwarf stars

    CERN Document Server

    Ciceri, S; Henning, T; Bakos, G Á; Penev, K; Brahm, R; Zhou, G; Hartman, J D; Bayliss, D; Jordán, A; Csubry, Z; de Val-Borro, M; Bhatti, W; Rabus, M; Espinoza, N; Suc, V; Schmidt, B; Noyes, R; Howard, A W; Fulton, B J; Isaacson, H; Marcy, G W; Butler, R P; Arriagada, P; Crane, J; Shectman, S; Thompson, I; Tan, T G; Lázár, J; Papp, I; Sari, P

    2015-01-01

    We report the discovery of HATS-15 b and HATS-16 b, two massive transiting extrasolar planets orbiting evolved ($\\sim 10$ Gyr) main-sequence stars. The planet HATS-15 b, which is hosted by a G9V star ($V=14.8$ mag), is a hot Jupiter with mass of $2.17\\pm0.15\\, M_{\\mathrm{J}}$ and radius of $1.105\\pm0.0.040\\, R_{\\mathrm{J}}$, and completes its orbit in nearly 1.7 days. HATS-16 b is a very massive hot Jupiter with mass of $3.27\\pm0.19\\, M_{\\mathrm{J}}$ and radius of $1.30\\pm0.15\\, R_{\\mathrm{J}}$; it orbits around its G3 V parent star ($V=13.8$ mag) in $\\sim2.7$ days. HATS-16 is slightly active and shows a periodic photometric modulation, implying a rotational period of 12 days which is unexpectedly short given its isochronal age. This fast rotation might be the result of the tidal interaction between the star and its planet.

  16. Dissecting the Molecular Roles of Histone Chaperones in Histone Acetylation by Type B Histone Acetyltransferases (HAT-B).

    Science.gov (United States)

    Haigney, Allison; Ricketts, M Daniel; Marmorstein, Ronen

    2015-12-18

    The HAT-B enzyme complex is responsible for acetylating newly synthesized histone H4 on lysines K5 and K12. HAT-B is a multisubunit complex composed of the histone acetyltransferase 1 (Hat1) catalytic subunit and the Hat2 (rbap46) histone chaperone. Hat1 is predominantly localized in the nucleus as a member of a trimeric NuB4 complex containing Hat1, Hat2, and a histone H3-H4 specific histone chaperone called Hif1 (NASP). In addition to Hif1 and Hat2, Hat1 interacts with Asf1 (anti-silencing function 1), a histone chaperone that has been reported to be involved in both replication-dependent and -independent chromatin assembly. To elucidate the molecular roles of the Hif1 and Asf1 histone chaperones in HAT-B histone binding and acetyltransferase activity, we have characterized the stoichiometry and binding mode of Hif1 and Asf1 to HAT-B and the effect of this binding on the enzymatic activity of HAT-B. We find that Hif1 and Asf1 bind through different modes and independently to HAT-B, whereby Hif1 binds directly to Hat2, and Asf1 is only capable of interactions with HAT-B through contacts with histones H3-H4. We also demonstrate that HAT-B is significantly more active against an intact H3-H4 heterodimer over a histone H4 peptide, independent of either Hif1 or Asf1 binding. Mutational studies further demonstrate that HAT-B binding to the histone tail regions is not sufficient for this enhanced activity. Based on these data, we propose a model for HAT-B/histone chaperone assembly and acetylation of H3-H4 complexes.

  17. Stable S/MAR-based episomal vectors are regulated at the chromatin level

    NARCIS (Netherlands)

    F. Tessadori; K. Zeng; E. Manders; M. Riool; D. Jackson; R. van Driel

    2010-01-01

    Episomal vectors assembled from defined genetic components are a promising alternative to traditional gene therapy vectors that integrate in the host genome and may cause insertional mutations. The vector pEPI-eGFP is stably retained in the episomal state in cultured mammalian cells at low copy numb

  18. Molecular basis for oligomeric-DNA binding and episome maintenance by KSHV LANA.

    Directory of Open Access Journals (Sweden)

    John F Domsic

    Full Text Available LANA is the KSHV-encoded terminal repeat binding protein essential for viral replication and episome maintenance during latency. We have determined the X-ray crystal structure of LANA C-terminal DNA binding domain (LANADBD to reveal its capacity to form a decameric ring with an exterior DNA binding surface. The dimeric core is structurally similar to EBV EBNA1 with an N-terminal arm that regulates DNA binding and is required for replication function. The oligomeric interface between LANA dimers is dispensable for single site DNA binding, but is required for cooperative DNA binding, replication function, and episome maintenance. We also identify a basic patch opposite of the DNA binding surface that is responsible for the interaction with BRD proteins and contributes to episome maintenance function. The structural features of LANADBD suggest a novel mechanism of episome maintenance through DNA-binding induced oligomeric assembly.

  19. 30 CFR 57.15002 - Hard hats.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Hard hats. 57.15002 Section 57.15002 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND... Underground § 57.15002 Hard hats. All persons shall wear suitable hard hats when in or around a mine or...

  20. 30 CFR 56.15002 - Hard hats.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Hard hats. 56.15002 Section 56.15002 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Personal Protection § 56.15002 Hard hats. All persons shall wear suitable hard hats when in or around a mine or plant where falling...

  1. The stealth episome: suppression of gene expression on the excised genomic island PPHGI-1 from Pseudomonas syringae pv. phaseolicola.

    Directory of Open Access Journals (Sweden)

    Scott A C Godfrey

    2011-03-01

    Full Text Available Pseudomonas syringae pv. phaseolicola is the causative agent of halo blight in the common bean, Phaseolus vulgaris. P. syringae pv. phaseolicola race 4 strain 1302A contains the avirulence gene avrPphB (syn. hopAR1, which resides on PPHGI-1, a 106 kb genomic island. Loss of PPHGI-1 from P. syringae pv. phaseolicola 1302A following exposure to the hypersensitive resistance response (HR leads to the evolution of strains with altered virulence. Here we have used fluorescent protein reporter systems to gain insight into the mobility of PPHGI-1. Confocal imaging of dual-labelled P. syringae pv. phaseolicola 1302A strain, F532 (dsRFP in chromosome and eGFP in PPHGI-1, revealed loss of PPHGI-1::eGFP encoded fluorescence during plant infection and when grown in vitro on extracted leaf apoplastic fluids. Fluorescence-activated cell sorting (FACS of fluorescent and non-fluorescent PPHGI-1::eGFP F532 populations showed that cells lost fluorescence not only when the GI was deleted, but also when it had excised and was present as a circular episome. In addition to reduced expression of eGFP, quantitative PCR on sub-populations separated by FACS showed that transcription of other genes on PPHGI-1 (avrPphB and xerC was also greatly reduced in F532 cells harbouring the excised PPHGI-1::eGFP episome. Our results show how virulence determinants located on mobile pathogenicity islands may be hidden from detection by host surveillance systems through the suppression of gene expression in the episomal state.

  2. Differential methylation of E2 binding sites in episomal and integrated HPV 16 genomes in preinvasive and invasive cervical lesions.

    Science.gov (United States)

    Chaiwongkot, Arkom; Vinokurova, Svetlana; Pientong, Chamsai; Ekalaksananan, Tipaya; Kongyingyoes, Bunkerd; Kleebkaow, Pilaiwan; Chumworathayi, Bandit; Patarapadungkit, Natcha; Reuschenbach, Miriam; von Knebel Doeberitz, Magnus

    2013-05-01

    Enhanced expression of the HPV 16 E6-E7 oncogenes may trigger neoplastic transformation of the squamous epithelial cells at the uterine cervix. The HPV E2 protein is a key transcriptional regulator of the E6-E7 genes. It binds to four E2 binding sites (E2BSs 1-4) in the viral upstream regulatory region (URR). Modification of E2 functions, for example, by methylation of E2BSs is hypothesized to trigger enhanced expression of the viral E6-E7 oncogenes. In the majority of HPV-transformed premalignant lesions and about half of cervical carcinomas HPV genomes persist in an extra-chromosomal, episomal state, whereas they are integrated into host cells chromosomes in the remaining lesions. Here we compared the methylation profile of E2BSs 1-4 of the HPV 16 URR in a series of 18 HPV16-positive premalignant lesions and 33 invasive cervical cancers. CpGs within the E2BSs 1, 3, and 4 were higher methylated in all lesions with only episomal HPV16 genomes compared with lesions displaying single integrated copies. Samples with multiple HPV16 integrated copies displayed high methylation levels for all CpGs suggesting that the majority of multiple copies were silenced by extensive methylation. These data support the hypothesis that differential methylation of the E2BSs 1, 3 and 4 is related to the activation of viral oncogene expression in cervical lesions as long as the viral genome remains in the episomal state. Once the virus becomes integrated into host cell chromosomes these methylation patterns may be substantially altered due to complex epigenetic changes of integrated HPV genomes.

  3. DIY teleport hats - the consolation of technology

    DEFF Research Database (Denmark)

    Hansen, Lone Koefoed

    2009-01-01

    This instructable describes how to make a set of teleport hats. A teleport hat is a crocheted hat which doubles as a device with which you can teleport yourself to a person wearing the same type of hat in case you miss oneanother and want to be together without the hassle of driving, jetting...... or biking there. This particular set is made in the free-form crochet style: there is no exact pattern to crochet from, instead you crochet in an iterative process alternating between crocheting and trying the hat on for size and pattern adaptations. Disclaimer: It is of course not a functioning device...

  4. HAT-P-38h

    DEFF Research Database (Denmark)

    Sato, Bun'ei; Hartman, Joel D.; Bakos, Gaspar A.;

    2012-01-01

    We report on the discovery of HAT-P-38b, a Saturn-mass exoplanet, transiting the V = 12.56 dwarf star GSC 2314-00559 on a P = 4.6404 d circular orbit. The host star is a 0.89 M-circle dot late G dwarf, with solar metallicity and a radius of 0.92 R-circle dot. The planetary companion has a mass of 0.......27 M-J and a radius of 0.82 R-J. HAT-P-38b is one of the planets the mass and radius of which have ever been discovered to be the closest to those of Saturn....

  5. HAT-P-16b

    DEFF Research Database (Denmark)

    Buchhave, Lars A.; Bakos, G. A.; Hartman, J. D.;

    2010-01-01

    We report the discovery of HAT-P-16b, a transiting extrasolar planet orbiting the V = 10.8 mag F8 dwarf GSC 2792-01700, with a period P = 2.775960 ± 0.000003 days, transit epoch Tc = 2455027.59293 ± 0.00031 (BJD10), and transit duration 0.1276 ± 0.0013 days. The host star has a mass of 1.22 ± 0.0...

  6. HAT-P-25b

    DEFF Research Database (Denmark)

    Quinn, S.N.; Bakos, G. 'A; Hartman, J.;

    2012-01-01

    We report the discovery of HAT-P-25b, a transiting extrasolar planet orbiting the V = 13.19 G5 dwarf star GSC 1788-01237, with a period P = 3.652836 +/- 0.000019 days, transit epoch Tc = 2455176.85173 +/- 0.00047 (BJD), and transit duration 0.1174 +/- 0.0017 days. The host star has mass of 1.01 +...

  7. The HAT-P-7 and HAT-P-11 Star-Planet Systems

    Science.gov (United States)

    Medina, Jennifer; Manrique, Maria; van Hamme, Walter

    2016-03-01

    Radial velocities and KEPLER light curves of the transiting exoplanets HAT-P-7b and HAT-P-11b are analyzed using a general binary star model. The HAT-P-7 system has been a subject of interest due to the irregular orbit of the HAT-P-7b exoplanet with respect to its parent star. HAT-P-7b's orbit has shed light on the diversity of systems that exist in our observable Universe. HAT-P-11 hosts a K type variable star which we were able to analyze with a fourier fit on the light curve data. It is also a host to exoplanet HAT-P-11b which has a slightly inclined orbit. Using our own software, we have calculated the parameters for star-planet pair of HAT-P-7 and HAT-P-11. This presents another way for astronomers to study these complex systems.

  8. Plasticity of DNA replication initiation in Epstein-Barr virus episomes.

    Directory of Open Access Journals (Sweden)

    Paolo Norio

    2004-06-01

    Full Text Available In mammalian cells, the activity of the sites of initiation of DNA replication appears to be influenced epigenetically, but this regulation is not fully understood. Most studies of DNA replication have focused on the activity of individual initiation sites, making it difficult to evaluate the impact of changes in initiation activity on the replication of entire genomic loci. Here, we used single molecule analysis of replicated DNA (SMARD to study the latent duplication of Epstein-Barr virus (EBV episomes in human cell lines. We found that initiation sites are present throughout the EBV genome and that their utilization is not conserved in different EBV strains. In addition, SMARD shows that modifications in the utilization of multiple initiation sites occur across large genomic regions (tens of kilobases in size. These observations indicate that individual initiation sites play a limited role in determining the replication dynamics of the EBV genome. Long-range mechanisms and the genomic context appear to play much more important roles, affecting the frequency of utilization and the order of activation of multiple initiation sites. Finally, these results confirm that initiation sites are extremely redundant elements of the EBV genome. We propose that these conclusions also apply to mammalian chromosomes.

  9. HATS-19b, HATS-20b, HATS-21b: Three Transiting Hot-Saturns Discovered by the HATSouth Survey

    OpenAIRE

    Bhatti, W.; Bakos, G. Á.; Hartman, J. D.; Zhou, G.; Penev, K.; Bayliss, D.; Jordán, A.; Brahm, R.; Espinoza, N.; Rabus, M.; Mancini, L; de Val-Borro, M.; Bento, J; Ciceri, S.; Csubry, Z.

    2016-01-01

    We report the discovery by the HATSouth exoplanet survey of three hot-Saturn transiting exoplanets: HATS-19b, HATS-20b, and HATS-21b. The planet host HATS-19 is a slightly evolved V = 13.0 G0 star with [Fe/H] = 0.240, a mass of 1.303 Msun, and a radius of 1.75 Rsun. HATS-19b is in an eccentric orbit (e = 0.30) around this star with an orbital period of 4.5697 days and has a mass of 0.427 Mjup and a highly inflated radius of 1.66 Rjup. The planet HATS-20b has a Saturn-like mass and radius of 0...

  10. HATS-19b, HATS-20b, HATS-21b: Three Transiting Hot-Saturns Discovered by the HATSouth Survey

    CERN Document Server

    Bhatti, W; Hartman, J D; Zhou, G; Penev, K; Bayliss, D; Jordán, A; Brahm, R; Espinoza, N; Rabus, M; Mancini, L; de Val-Borro, M; Bento, J; Ciceri, S; Csubry, Z; Henning, T; Schmidt, B; Arriagada, P; Butler, R P; Crane, J; Shectman, S; Thompson, I; Tan, T G; Suc, V; Lázár, J; Papp, I; Sári, P

    2016-01-01

    We report the discovery by the HATSouth exoplanet survey of three hot-Saturn transiting exoplanets: HATS-19b, HATS-20b, and HATS-21b. The planet host HATS-19 is a slightly evolved V = 13.0 G0 star with [Fe/H] = 0.240, a mass of 1.303 Msun, and a radius of 1.75 Rsun. HATS-19b is in an eccentric orbit (e = 0.30) around this star with an orbital period of 4.5697 days and has a mass of 0.427 Mjup and a highly inflated radius of 1.66 Rjup. The planet HATS-20b has a Saturn-like mass and radius of 0.273 Mjup and 0.776 Rjup respectively. It orbits the V = 13.8 G9V star HATS-20 (Ms = 0.910 Msun; Rs = 0.892 Rsun) with a period of 3.7993 days. Finally, HATS-21 is a V = 12.2 G4V star with [Fe/H] = 0.300, a mass of 1.080 Msun, and a radius of 1.021 Rsun. Its accompanying planet HATS-21b has a 3.5544-day orbital period, a mass of 0.332 Mjup, and a moderately inflated radius of 1.123 Rjup. With the addition of these three very different planets to the growing sample of hot-Saturns, we re-examine the relations between the ob...

  11. Gamma-herpesvirus latency requires T cell evasion during episome maintenance.

    Directory of Open Access Journals (Sweden)

    Neil J Bennett

    2005-04-01

    Full Text Available The gamma-herpesviruses persist as latent episomes in a dynamic lymphocyte pool. Their consequent need to express a viral episome maintenance protein presents a potential immune target. The glycine-alanine repeat of the Epstein-Barr virus episome maintenance protein, EBNA-1, limits EBNA-1 epitope presentation to CD8(+ T lymphocytes (CTLs. However, CTL recognition occurs in vitro, so the significance of such evasion for viral fitness is unclear. We used the murine gamma-herpesvirus-68 (MHV-68 to define the in vivo contribution of cis-acting CTL evasion to host colonisation. Although the ORF73 episome maintenance protein of MHV-68 lacks a glycine-alanine repeat, it was equivalent to EBNA-1 in conferring limited presentation on linked epitopes. This was associated with reduced protein synthesis and reduced protein degradation. We bypassed the cis-acting evasion of ORF73 by using an internal ribosome entry site to express in trans-a CTL target from the same mRNA. This led to a severe, MHC class I-restricted and CTL-dependent reduction in viral latency. Thus, despite MHV-68 encoding at least two trans-acting CTL evasion proteins, cis-acting evasion during episome maintenance was essential for normal host colonisation.

  12. Long-term surveillance plan for the Mexican Hat disposal site, Mexican Hat, Utah

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-01-01

    This plan describes the long-term surveillance activities for the Uranium Mill Tailings Remedial Action (UMTRA) Project disposal site at Mexican Hat, Utah. The US Department of Energy (DOE) will carry out these activities to ensure that the disposal site continues to function as designed. This long-term surveillance plan (LTSP) was prepared as a requirement for acceptance under the US Nuclear Regulatory Commission (NRC) general license for custody and long-term care of residual radioactive material (RRM). This LTSPC documents the land ownership interests and details how the long-term care of the disposal site will be accomplished.

  13. HATS-15b and HATS-16b: Two Massive Planets Transiting Old G Dwarf Stars

    Science.gov (United States)

    Ciceri, S.; Mancini, L.; Henning, T.; Bakos, G.; Penev, K.; Brahm, R.; Zhou, G.; Hartman, J. D.; Bayliss, D.; Jordán, A.; Csubry, Z.; de Val-Borro, M.; Bhatti, W.; Rabus, M.; Espinoza, N.; Suc, V.; Schmidt, B.; Noyes, R.; Howard, A. W.; Fulton, B. J.; Isaacson, H.; Marcy, G. W.; Butler, R. P.; Arriagada, P.; Crane, J. D.; Shectman, S.; Thompson, I.; Tan, T. G.; Lázár, J.; Papp, I.; Sari, P.

    2016-07-01

    We report the discovery of HATS-15 b and HATS-16 b, two massive transiting extrasolar planets orbiting evolved (∼10 Gyr) main-sequence stars. The planet HATS-15 b, which is hosted by a G9 V star (V=14.8 mag), is a hot Jupiter with mass of 2.17\\quad +/- \\quad 0.15 {M}{{J}} and radius of 1.105\\quad +/- \\quad 0.040 {R}{{J}}, and it completes its orbit in about 1.7 days. HATS-16 b is a very massive hot Jupiter with mass of 3.27\\quad +/- \\quad 0.19 {M}{{J}} and radius of 1.30\\quad +/- \\quad 0.15 {R}{{J}}; it orbits around its G3 V parent star (V=13.8 mag) in ∼2.7 days. HATS-16 is slightly active and shows a periodic photometric modulation, implying a rotational period of 12 days, which is unexpectedly short given its isochronal age. This fast rotation might be the result of the tidal interaction between the star and its planet. The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia Universidad Católica de Chile (PUC). The station at Las Campanas Observatory (LCO) of the Carnegie Institute is operated by PU in conjunction with PUC, the station at the High Energy Spectroscopic Survey (H.E.S.S.) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU. Based in part on observations performed at the ESO La Silla Observatory in Chile, with the Coralie and FEROS spectrographs mounted on the Euler-Swiss and MPG 2.2 m telescopes, respectively. This paper includes data gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile. Based in part on data collected at Keck Telescope. Observations obtained with facilities of the Las Cumbres Observatory Global Telescope are used in this paper.

  14. Tip60 HAT Action Mediates Environmental Enrichment Induced Cognitive Restoration.

    Science.gov (United States)

    Xu, Songjun; Panikker, Priyalakshmi; Iqbal, Sahira; Elefant, Felice

    2016-01-01

    Environmental enrichment (EE) conditions have beneficial effects for reinstating cognitive ability in neuropathological disorders like Alzheimer's disease (AD). While EE benefits involve epigenetic gene control mechanisms that comprise histone acetylation, the histone acetyltransferases (HATs) involved remain largely unknown. Here, we examine a role for Tip60 HAT action in mediating activity- dependent beneficial neuroadaptations to EE using the Drosophila CNS mushroom body (MB) as a well-characterized cognition model. We show that flies raised under EE conditions display enhanced MB axonal outgrowth, synaptic marker protein production, histone acetylation induction and transcriptional activation of cognition linked genes when compared to their genotypically identical siblings raised under isolated conditions. Further, these beneficial changes are impaired in both Tip60 HAT mutant flies and APP neurodegenerative flies. While EE conditions provide some beneficial neuroadaptive changes in the APP neurodegenerative fly MB, such positive changes are significantly enhanced by increasing MB Tip60 HAT levels. Our results implicate Tip60 as a critical mediator of EE-induced benefits, and provide broad insights into synergistic behavioral and epigenetic based therapeutic approaches for treatment of cognitive disorder. PMID:27454757

  15. The hat problem on a directed graph

    CERN Document Server

    Hod, Rani

    2010-01-01

    A team of players plays the following game. After a strategy session, each player is randomly fitted with a blue or red hat. Then, without further communication, everybody can try to guess simultaneously his or her own hat color by looking at the hat colors of other players. Visibility is defined by a directed graph; that is, vertices correspond to players, and a player can see each player to whom she or he is connected by an arc. The team wins if at least one player guesses his hat color correctly, and no one guesses his hat color wrong; otherwise the team loses. The team aims to maximize the probability of a win, and this maximum is called the hat number of the graph. Previous works focused on the problem on complete graphs and on undirected graphs. Some cases were solved, e.g., complete graphs of certain orders, trees, cycles, bipartite graphs. These led Uriel Feige to conjecture that the hat number of any graph is equal to the hat number of its maximum clique. We show that the conjecture does not hold for...

  16. ERRATUM: Work smart, wear your hard hat

    CERN Multimedia

    2003-01-01

    An error appeared in the article «Work smart, wear your hard hat» published in Weekly Bulletin 27/2003, page 5. The impact which pierced a hole in the hard hat worn by Gerd Fetchenhauer was the equivalent of a box weighing 5 kg and not 50 kg.

  17. Long-term surveillance plan for the Mexican Hat disposal site Mexican Hat, Utah

    International Nuclear Information System (INIS)

    This long-term surveillance plan (LTSP) describes the U.S. Department of Energy's (DOE) long-term care program for the Uranium Mill Tailings Remedial Action (UMTRA) Project Mexican Hat, Utah, disposal site. The U.S. Nuclear Regulatory Commission (NRC) has developed regulations for the issuance of a general license for the custody and long-term care of UMTRA Project disposal sites in 10 CFR Part 40. The purpose of this general license is to ensure that the UMTRA Project disposal sites will be cared for in a manner that protects the public health and safety and the environment. Before each disposal site is licensed, the NRC requires the DOE to submit a site-specific LTSP. The DOE prepared this LTSP to meet this requirement for the Mexican Hat disposal site. The general license becomes effective when the NRC concurs with the DOE's determination of completion of remedial action for the disposal site and the NRC formally accepts this LTSP. This LTSP describes the long-term surveillance program the DOE will implement to ensure that the Mexican Hat disposal site performs as designed. The program is based on two distinct types of activities: (1) site inspections to identify potential threats to disposal cell integrity, and (2) monitoring of selected seeps to observe changes in flow rates and water quality. The LTSP is based on the UMTRA Project long-term surveillance program guidance and meets the requirements of 10 CFR section 40.27(b) and 40 CFR section 192.03. 18 refs., 6 figs., 1 tab

  18. Impact of Different Promoters on Episomal Vectors Harbouring Characteristic Motifs of Matrix Attachment Regions.

    Science.gov (United States)

    Wang, Xiao-Yin; Zhang, Jun-He; Zhang, Xi; Sun, Qiu-Li; Zhao, Chun-Peng; Wang, Tian-Yun

    2016-01-01

    We previously demonstrated that the characteristic sequence of matrix attachment regions (MARs) allows transgenes to be maintained episomally in CHO cells. In the present study, six commonly used promoters from human cytomegalovirus major immediate-early (CMV), simian vacuolating virus 40 (SV40), Rous sarcoma virus, Homo sapiens ubiquitin C, phosphoglycerate kinase, and β-globin, respectively, were evaluated to determine their effects on transgene expression and stability in CHO cells stably transfected via the episomal vector harbouring characteristic MAR motifs. The CHO cells were transfected with vectors and then screened using G418, after which the stably transfected cells were split into two and further cultured either in the presence or absence of G418. Of the six promoters, the CMV promoter yielded the highest transgene expression levels and the highest transfection efficiency, whereas the SV40 promoter maintained transgene expression more stably during long-term culture than the other promoters did. The CMV and SV40 promoter-containing vectors were furthermore episomally maintained and conferred sustained eGFP expression in the cells even under nonselective conditions. On the basis of these findings, we conclude that the CMV promoter performs best in terms of yielding both high expression levels and high levels of stability using this episomal vector system. PMID:27226236

  19. HATS-22b, HATS-23b and HATS-24b: Three new transiting Super-Jupiters from the HATSouth Project

    CERN Document Server

    Bento, Joao; Hartman, Joel; Bakos, Gaspar; Ciceri, Simona; Brahm, Rafael; Bayliss, Daniel; Espinoza, Nestor; Zhou, George; Rabus, Markus; Bhatti, Waqas; Penev, Kaloyan; Csubry, Zoltan; Jordan, Andres; Mancini, Luigi; Henning, Thomas; de Val-Borro, Miguel; Tinney, Chris; Wright, Duncan; Suc, Vincent; Noyes, Robert; Lazar, Jozsef; Papp, Istvan; Sari, Pal

    2016-01-01

    We report the discovery of three moderately high-mass transiting hot Jupiters from the HATSouth survey: HATS-22b, HATS-23b and HATS-24b. These planets add to the numbers of known planets in the ~2MJ regime. HATS-22b is a 2.74+/-0.11 MJ mass and 0.953+0.048/-0.029 RJ radius planet orbiting a V = 13.455 +/- 0.040 sub-silar mass (M_star = 0.759+/-0.019 M_sun; R_star = 0.759+/-0.019 R_sun) K-dwarf host star on an eccentric (e = 0.079 +/- 0.026) orbit. This planet's high planet-to-stellar mass ratio is further evidence that migration mechanisms for hot Jupiters may rely on exciting orbital eccentricities that bring planets closer to their parent stars followed by tidal circularisation. HATS-23b is a 1.478 +/- 0.080 MJ mass and 1.69 +/- 0.24 RJ radius planet on a grazing orbit around a V = 13.901 +/- 0.010 G-dwarf with properties very similar to those of the Sun (M_star = 1.115 +/- 0.054 M_sun; R_star = 1.145 +/- 0.070 R_sun). HATS-24b orbits a moderately bright V = 12.830 +/- 0.010 F-dwarf star (M_star = 1.218 +/-...

  20. "Work smart, wear your hard hat"

    CERN Multimedia

    2003-01-01

    Falling objects and collisions are frequent occurrences in work sites and hazardous areas. Hard hats can help prevent many types of accident and can even save lives. Just imagine an 800 g spanner falling from a 13 m high scaffold onto the head of someone standing below - a nightmare scenario! The impact to the head is equivalent to that of a 5 kg weight falling from 2 metres. That is just what happened to Gerd Fetchenhauer when he was working on the UA1 experiment. Fortunately, he was wearing a hard hat at the time. "That hat saved my life," he explains. "It punched a hole right through the hat and I was a bit dazed for a couple of hours but otherwise I was OK." Since that day, Gerd Fetchenhauer, now working on CMS, is never seen on a work site without his hard hat on. Work sites have proliferated at CERN with the construction of the LHC and its detectors, and the wearing of hard hats is compulsory (not to mention life-saving). In the underground caverns and experiment halls, where gantry cranes and other h...

  1. Long-term surveillance plan for the Mexican Hat Disposal Site, Mexican Hat, Utah

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    This plan describes the long-term surveillance activities for the Uranium Mill Tailings Remedial Action (UMTRA) Project disposal site at Mexican Hat, Utah. The U.S. Department of Energy (DOE) will carry out these activities to ensure that the disposal site continues to function as designed. This long-term surveillance plan (LTSP) was prepared as a requirement for acceptance under the U.S. Nuclear Regulatory Commission (NRC) general license for custody and long-term care of residual radioactive material (RRM). This LTSP (based on the DOE`s Guidance for Implementing the UMTRA Project Long-term Surveillance Program), documents the land ownership interests and details how the long-term care of the disposal site will be accomplished.

  2. Final report. Human artificial episomal chromosome (HAEC) for building large genomic libraries

    Energy Technology Data Exchange (ETDEWEB)

    Jean-Michael H. Vos

    1999-12-09

    Collections of human DNA fragments are maintained for research purposes as clones in bacterial host cells. However for unknown reasons, some regions of the human genome appear to be unclonable or unstable in bacteria. Their team has developed a system using episomes (extrachromosomal, autonomously replication DNA) that maintains large DNA fragments in human cells. This human artificial episomal chromosomal (HAEC) system may prove useful for coverage of these especially difficult regions. In the broader biomedical community, the HAEC system also shows promise for use in functional genomics and gene therapy. Recent improvements to the HAEC system and its application to mapping, sequencing, and functionally studying human and mouse DNA are summarized. Mapping and sequencing the human genome and model organisms are only the first steps in determining the function of various genetic units critical for gene regulation, DNA replication, chromatin packaging, chromosomal stability, and chromatid segregation. Such studies will require the ability to transfer and manipulate entire functional units into mammalian cells.

  3. On the hat problem, its variations, and their applications

    Directory of Open Access Journals (Sweden)

    Marcin Piotr Krzywkowski

    2010-03-01

    Full Text Available The topic of our paper is the hat problem in which each of n players is randomly fitted with a blue or red hat. Then everybody can try to guess simultaneously his own hat color by looking at the hat colors of the other players. The team wins if at least one player guesses his hat color correctly, and no one guesses his hat color wrong; otherwise the team loses. The aim is to maximize the probability of a win. There are known many variations of the hat problem. In this paper we give a comprehensive list of variations considered in the literature. We describe the applications of the hat problem and its variations, and their connections to different areas of science. We give the full bibliography of any papers, books, and electronic publications about the hat problem.

  4. HATS-31b Through HATS-35b: Five Transiting Hot Jupiters Discovered by the HATSouth Survey

    CERN Document Server

    de Val-Borro, M; Brahm, R; Hartman, J D; Espinoza, N; Penev, K; Ciceri, S; Jordán, A; Bhatti, W; Csubry, Z; Bayliss, D; Bento, J; Zhou, G; Rabus, M; Mancini, L; Henning, T; Schmidt, B; Tan, T G; Tinney, C G; Wright, D J; Kedziora-Chudczer, L; Bailey, J; Suc, V; Lázár, J; Papp, I; Sári, P

    2016-01-01

    We report the discovery of five new transiting hot Jupiter planets discovered by the HATSouth survey: HATS-31b through HATS-35b. These planets orbit moderately bright stars with V magnitudes within the range 11.9-14.4mag while the planets span a range of masses 0.88-1.22MJ, and have somewhat inflated radii between 1.23-1.64RJ.These planets can be classified as typical hot Jupiters, with HATS-31b and HATS-35b being moderately inflated gas giant planets with radii of $1.64 \\pm 0.22$ RJ and 1.464+0.069-0.044RJ, respectively, that can be used to constrain inflation mechanisms. All five systems present a higher Bayesian evidence for a fixed circular orbit model than for an eccentric orbit. The orbital periods range from $1.8209993 \\pm 0.0000016$ day for HATS-35b) to $3.377960 \\pm 0.000012$ day for HATS-31b. Additionally, HATS-35b orbits a relatively young F star with an age of $2.13 \\pm 0.51$ Gyr. We discuss the analysis to derive the properties of these systems and compare them in the context of the sample of wel...

  5. Limitations of Short Range Mexican Hat Connection for Driving Target Selection in a 2D Neural Field: Activity Suppression and Deviation from Input Stimuli.

    Directory of Open Access Journals (Sweden)

    Geoffrey eMégardon

    2015-10-01

    Full Text Available Dynamic Neural Field models (DNF often use a kernel of connection with short range excitation and long range inhibition. This organization has been suggested as a model for brain structures or for artificial systems involved in winner-take-all processes such as saliency localisation, perceptual decision or target/action selection. A good example of such a DNF is the superior colliculus (SC, a key structure for eye movements. Recent results suggest that the superficial layers of the SC (SCs exhibit relatively short range inhibition with a longer time constant than excitation. The aim of the present study was to further examine the properties of a DNF with such an inhibition pattern in the context of target selection. First we tested the effects of stimulus size and shape on when and where self-maintained clusters of firing neurons appeared, using three variants of the model. In each model variant, small stimuli led to rapid formation of a spiking cluster, a range of medium sizes led to the suppression of any activity on the network and hence to no target selection, while larger sizes led to delayed selection of multiple loci. Second, we tested the model with two stimuli separated by a varying distance. Again single, none, or multiple spiking clusters could occur, depending on distance and relative stimulus strength. For short distances, activity attracted towards the strongest stimulus, reminiscent of well-known behavioural data for saccadic eye movements, while for larger distances repulsion away from the second stimulus occurred. All these properties predicted by the model suggest that the SCs, or any other neural structure thought to implement a short range MH, is an imperfect winner-take-all system. Although those properties call for systematic testing, the discussion gathers neurophysiological and behavioural data suggesting that such properties are indeed present in target selection for saccadic eye movements.

  6. Genome-wide cooperation by HAT Gcn5, remodeler SWI/SNF, and chaperone Ydj1 in promoter nucleosome eviction and transcriptional activation.

    Science.gov (United States)

    Qiu, Hongfang; Chereji, Răzvan V; Hu, Cuihua; Cole, Hope A; Rawal, Yashpal; Clark, David J; Hinnebusch, Alan G

    2016-02-01

    Chaperones, nucleosome remodeling complexes, and histone acetyltransferases have been implicated in nucleosome disassembly at promoters of particular yeast genes, but whether these cofactors function ubiquitously, as well as the impact of nucleosome eviction on transcription genome-wide, is poorly understood. We used chromatin immunoprecipitation of histone H3 and RNA polymerase II (Pol II) in mutants lacking single or multiple cofactors to address these issues for about 200 genes belonging to the Gcn4 transcriptome, of which about 70 exhibit marked reductions in H3 promoter occupancy on induction by amino acid starvation. Examining four target genes in a panel of mutants indicated that SWI/SNF, Gcn5, the Hsp70 cochaperone Ydj1, and chromatin-associated factor Yta7 are required downstream from Gcn4 binding, whereas Asf1/Rtt109, Nap1, RSC, and H2AZ are dispensable for robust H3 eviction in otherwise wild-type cells. Using ChIP-seq to interrogate all 70 exemplar genes in single, double, and triple mutants implicated Gcn5, Snf2, and Ydj1 in H3 eviction at most, but not all, Gcn4 target promoters, with Gcn5 generally playing the greatest role and Ydj1 the least. Remarkably, these three cofactors cooperate similarly in H3 eviction at virtually all yeast promoters. Defective H3 eviction in cofactor mutants was coupled with reduced Pol II occupancies for the Gcn4 transcriptome and the most highly expressed uninduced genes, but the relative Pol II levels at most genes were unaffected or even elevated. These findings indicate that nucleosome eviction is crucial for robust transcription of highly expressed genes but that other steps in gene activation are more rate-limiting for most other yeast genes.

  7. HATS-13b and HATS-14b: two transiting hot Jupiters from the HATSouth survey

    CERN Document Server

    Mancini, L; Penev, K; Bakos, G A; Brahm, R; Ciceri, S; Henning, Th; Csubry, Z; Bayliss, D; Zhou, G; Rabus, M; de Val-Borro, M; Espinoza, N; Jordan, A; Suc, V; Bhatti, W; Schmidt, B; Sato, B; Tan, T G; Wright, D J; Tinney, C G; Addison, B C; Noyes, R W; Lazar, J; Papp, I; Sari, P

    2015-01-01

    We report the discovery of HATS-13b and HATS-14b, two hot-Jupiter transiting planets discovered by the HATSouth survey. The host stars are quite similar to each other (HATS-13: V = 13.9 mag, M* = 0.96 Msun, R* = 0.89 Rsun, Teff = 5500 K, [Fe/H] = 0.05; HATS-14: V = 13.8 mag, M* = 0.97 Msun, R* = 0.93 Rsun, Teff = 5350 K, [Fe/H] = 0.33) and both the planets orbit around them with a period of roughly 3 days and a separation of roughly 0.04 au. However, even though they are irradiated in a similar way, the physical characteristics of the two planets are very different. HATS-13b, with a mass of Mp = 0.543 MJ and a radius of Rp = 1.212 RJ, appears as an inflated planet, while HATS-14b, having a mass of Mp = 1.071 MJ and a radius of Rp = 1.039 RJ, is only slightly larger in radius than Jupiter.

  8. Generation of iPS Cells from Human Peripheral Blood Mononuclear Cells Using Episomal Vectors.

    Science.gov (United States)

    Su, Ruijun Jeanna; Neises, Amanda; Zhang, Xiao-Bing

    2016-01-01

    Peripheral blood is the easy-to-access, minimally invasive, and the most abundant cell source to use for cell reprogramming. The episomal vector is among the best approaches for generating integration-free induced pluripotent stem (iPS) cells due to its simplicity and affordability. Here we describe the detailed protocol for the efficient generation of integration-free iPS cells from peripheral blood mononuclear cells. With this optimized protocol, one can readily generate hundreds of iPS cell colonies from 1 ml of peripheral blood.

  9. Human Papilloma Viral DNA Replicates as a Stable Episome in Cultured Epidermal Keratinocytes

    Science.gov (United States)

    Laporta, Robert F.; Taichman, Lorne B.

    1982-06-01

    Human papilloma virus (HPV) is poorly understood because systems for its growth in tissue culture have not been developed. We report here that cultured human epidermal keratinocytes could be infected with HPV from plantar warts and that the viral DNA persisted and replicated as a stable episome. There were 50-200 copies of viral DNA per cell and there was no evidence to indicate integration of viral DNA into the cellular genome. There was also no evidence to suggest that viral DNA underwent productive replication. We conclude that cultured human epidermal keratinocytes may be a model for the study of certain aspects of HPV biology.

  10. Generation of Induced Pluripotent Stem Cells from Frozen Buffy Coats using Non-integrating Episomal Plasmids.

    Science.gov (United States)

    Meraviglia, Viviana; Zanon, Alessandra; Lavdas, Alexandros A; Schwienbacher, Christine; Silipigni, Rosamaria; Di Segni, Marina; Chen, Huei-Sheng Vincent; Pramstaller, Peter P; Hicks, Andrew A; Rossini, Alessandra

    2015-06-05

    Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by forcing the expression of four transcription factors (Oct-4, Sox-2, Klf-4, and c-Myc), typically expressed by human embryonic stem cells (hESCs). Due to their similarity with hESCs, iPSCs have become an important tool for potential patient-specific regenerative medicine, avoiding ethical issues associated with hESCs. In order to obtain cells suitable for clinical application, transgene-free iPSCs need to be generated to avoid transgene reactivation, altered gene expression and misguided differentiation. Moreover, a highly efficient and inexpensive reprogramming method is necessary to derive sufficient iPSCs for therapeutic purposes. Given this need, an efficient non-integrating episomal plasmid approach is the preferable choice for iPSC derivation. Currently the most common cell type used for reprogramming purposes are fibroblasts, the isolation of which requires tissue biopsy, an invasive surgical procedure for the patient. Therefore, human peripheral blood represents the most accessible and least invasive tissue for iPSC generation. In this study, a cost-effective and viral-free protocol using non-integrating episomal plasmids is reported for the generation of iPSCs from human peripheral blood mononuclear cells (PBMNCs) obtained from frozen buffy coats after whole blood centrifugation and without density gradient separation.

  11. Targeting Specific HATs for Neurodegenerative Disease Treatment: Translating Basic Biology to Therapeutic Possibilities

    Directory of Open Access Journals (Sweden)

    Sheila K. Pirooznia

    2013-03-01

    Full Text Available Dynamic epigenetic regulation of neurons is emerging as a fundamental mechanism by which neurons adapt their transcriptional responses to specific developmental and environmental cues. While defects within the neural epigenome have traditionally been studied in the context of early developmental and heritable cognitive disorders, recent studies point to aberrant histone acetylation status as a key mechanism underlying acquired inappropriate alterations of genome structure and function in post-mitotic neurons during the aging process. Indeed, it is becoming increasingly evident that chromatin acetylation status can be impaired during the lifetime of neurons through mechanisms related to loss of function of histone acetyltransferase (HATs activity. Several HATs have been shown to participate in vital neuronal functions such as regulation of neuronal plasticity and memory formation. As such, dysregulation of such HATs has been implicated in the pathogenesis associated with age-associated neurodegenerative diseases and cognitive decline. In order to counteract the loss of HAT function in neurodegenerative diseases, the current therapeutic strategies involve the use of small molecules called histone deacetylase (HDAC inhibitors that antagonize HDAC activity and thus enhance acetylation levels. Although this strategy has displayed promising therapeutic effects, currently used HDAC inhibitors lack target specificity, raising concerns about their applicability. With rapidly evolving literature on HATs and their respective functions in mediating neuronal survival and higher order brain function such as learning and memory, modulating the function of specific HATs holds new promises as a therapeutic tool in neurodegenerative diseases. In this review, we focus on the recent progress in research regarding epigenetic histone acetylation mechanisms underlying neuronal activity and cognitive function. We discuss the current understanding of specific HDACs and

  12. Radiologic characterization of the Mexican Hat, Utah, uranium mill tailings remedial action site: Addendum D1

    Energy Technology Data Exchange (ETDEWEB)

    Ludlam, J.R.

    1985-01-01

    This radiologic characterization of the inactive uranium millsite at Mexican Hat, Utah, was conducted by Bendix Field Engineering Corporation for the US Department of Energy (DOE), Grand Junctions Project Office in response to and in accord with a Statement of Work prepared by the DOE Uranium Mill Tailings Remedial Action Project (UMTRAP) Technical Assistance Contractor, Jacobs Engineering Group, Inc. The objective of this project was to determine the horizontal and vertical extent of contamination that exceeds the US Environmental Protection Agency (EPA) standards at the Mexican Hat site. The data presented in this report are required for characterization of the areas adjacent to the Mexican Hat tailings piles and for the subsequent design of cleanup activities. Some on- pile sampling was required to determine the depth of the 15-pCi/g Ra- 226 interface in an area where wind and water erosion has taken place.

  13. In vivo reinsertion of excised episomes by the V(DJ recombinase: a potential threat to genomic stability.

    Directory of Open Access Journals (Sweden)

    Katrina Vanura

    2007-03-01

    Full Text Available It has long been thought that signal joints, the byproducts of V(DJ recombination, are not involved in the dynamics of the rearrangement process. Evidence has now started to accumulate that this is not the case, and that signal joints play unsuspected roles in events that might compromise genomic integrity. Here we show both ex vivo and in vivo that the episomal circles excised during the normal process of receptor gene rearrangement may be reintegrated into the genome through trans-V(DJ recombination occurring between the episomal signal joint and an immunoglobulin/T-cell receptor target. We further demonstrate that cryptic recombination sites involved in T-cell acute lymphoblastic leukemia-associated chromosomal translocations constitute hotspots of insertion. Eventually, the identification of two in vivo cases associating episomal reintegration and chromosomal translocation suggests that reintegration events are linked to genomic instability. Altogether, our data suggest that V(DJ-mediated reintegration of episomal circles, an event likely eluding classical cytogenetic screenings, might represent an additional potent source of genomic instability and lymphoid cancer.

  14. Long-term surveillance plan for the Mexican Hat disposal site Mexican Hat, Utah

    International Nuclear Information System (INIS)

    This long-term surveillance plan (LTSP) describes the U.S. Department of Energy's (DOE) long-term care program for the Uranium Mill Tailings Remedial Action (UMTRA) Project Mexican Hat, Utah, disposal site. This LSTP describes the long-term surveillance program the DOE will implement to ensure the Mexican Hat disposal site performs as designed and is cared for in a manner that protects the public health and safety and the environment. Before each disposal site is licensed for custody and long-term care, the Nuclear Regulatory Commission (NRC) requires the DOE to submit such a site-specific LTSP

  15. Accurate episomal HIV 2-LTR circles quantification using optimized DNA isolation and droplet digital PCR

    Directory of Open Access Journals (Sweden)

    Eva Malatinkova

    2014-11-01

    Full Text Available Introduction: In HIV-infected patients on combination antiretroviral therapy (cART, the detection of episomal HIV 2-LTR circles is a potential marker for ongoing viral replication. Quantification of 2-LTR circles is based on quantitative PCR or more recently on digital PCR assessment, but is hampered due to its low abundance. Sample pre-PCR processing is a critical step for 2-LTR circles quantification, which has not yet been sufficiently evaluated in patient derived samples. Materials and Methods: We compared two sample processing procedures to more accurately quantify 2-LTR circles using droplet digital PCR (ddPCR. Episomal HIV 2-LTR circles were either isolated by genomic DNA isolation or by a modified plasmid DNA isolation, to separate the small episomal circular DNA from chromosomal DNA. This was performed in a dilution series of HIV-infected cells and HIV-1 infected patient derived samples (n=59. Samples for the plasmid DNA isolation method were spiked with an internal control plasmid. Results: Genomic DNA isolation enables robust 2-LTR circles quantification. However, in the lower ranges of detection, PCR inhibition caused by high genomic DNA load substantially limits the amount of sample input and this impacts sensitivity and accuracy. Moreover, total genomic DNA isolation resulted in a lower recovery of 2-LTR templates per isolate, further reducing its sensitivity. The modified plasmid DNA isolation with a spiked reference for normalization was more accurate in these low ranges compared to genomic DNA isolation. A linear correlation of both methods was observed in the dilution series (R2=0.974 and in the patient derived samples with 2-LTR numbers above 10 copies per million peripheral blood mononuclear cells (PBMCs, (R2=0.671. Furthermore, Bland–Altman analysis revealed an average agreement between the methods within the 27 samples in which 2-LTR circles were detectable with both methods (bias: 0.3875±1.2657 log10. Conclusions: 2-LTR

  16. HATS-25b through HATS-30b: A Half-dozen New Inflated Transiting Hot Jupiters from the HATSouth Survey

    CERN Document Server

    Espinoza, N; Hartman, J D; Bakos, G Á; Jordán, A; Zhou, G; Mancini, L; Brahm, R; Ciceri, S; Bhatti, W; Csubry, Z; Rabus, M; Penev, K; Bento, J; de Val-Borro, M; Henning, T; Schmidt, B; Suc, V; Wright, D J; Tinney, C G; Tan, T G; Noyes, R

    2016-01-01

    We report six new inflated hot Jupiters (HATS-25b through HATS-30b) discovered using the HATSouth global network of automated telescopes. The planets orbit stars with $V$ magnitudes in the range $\\sim 12-14$ and have masses in the largely populated $0.5M_J-0.7M_J$ region of parameter space but span a wide variety of radii, from $1.17R_J$ to $1.75 R_J$. HATS-25b, HATS-28b, HATS-29b and HATS-30b are typical inflated hot Jupiters ($R_p = 1.17-1.26R_J$) orbiting G-type stars in short period ($P=3.2-4.6$ days) orbits. However, HATS-26b ($R_p = 1.75R_J$, $P = 3.3024$ days) and HATS-27b ($R_p=1.50R_J$, $P=4.6370$ days) stand out as highly inflated planets orbiting slightly evolved F stars just after and in the turn-off points, respectively, which are among the least dense hot Jupiters, with densities of $0.153$ g cm$^{-3}$ and $0.180$ g cm$^{-3}$, respectively. All the presented exoplanets but HATS-27b are good targets for future atmospheric characterization studies, while HATS-27b is a prime target for Rossiter-McL...

  17. Research on Prehistoric Hats in Xinjiang (2000 BC-200 BC)

    OpenAIRE

    Xiaoyu Xin

    2015-01-01

    Based on archaeological evidence, this paper analyzes hats unearthed from prehistoric Xinjiang. Three typicalcategories of ancient hats can be recognized according to different styles and structures. And each of themrepresents the local dressing culture of different geographical areas of Xinjiang. Meanwhile, the similaritiesbetween prehistoric hats from Xinjiang and other Ancient tombs in Eurasia indicate early culturalcommunications between different civilizations from the Bronze Age to the ...

  18. VizieR Online Data Catalog: Spectroscopy and photometry for HAT-P-50--HAT-P-53 (Hartman+, 2015)

    Science.gov (United States)

    Hartman, J. D.; Bhatti, W.; Bakos, G. A.; Bieryla, A.; Kovacs, G.; Latham, D. W.; Csubry, Z.; de Val-Borro, M.; Penev, K.; Buchhave, L. A.; Torres, G.; Howard, A. W.; Marcy, G. W.; Johnson, J. A.; Isaacson, H.; Sato, B.; Boisse, I.; Falco, E.; Everett, M. E.; Szklenar, T.; Fulton, B. J.; Shporer, A.; Kovacs, T.; Hansen, T.; Beky, B.; Noyes, R. W.; Lazar, J.; Papp, I.; Sari, P.

    2016-04-01

    The HATNet network consists of six identical fully automated instruments, with four at Fred Lawrence Whipple Observatory (FLWO) in AZ, and two on the roof of the Submillimeter Array Hangar Building at Mauna Kea Observatory (MKO) in HI. The light-gathering elements of each instrument include an 11cm diameter telephoto lens, a Sloan r filter, and a 4K*4K front-side-illuminated CCD camera. Observations made in 2007 and early 2008 were carried out using a Cousins R filter. The instruments have a field of view of 10.6°*10.6° and a pixel scale of 9"/pixel at the center of an image. Additional time-series photometric measurements were obtained for all four of the systems using Keplercam on the FLWO 1.2m telescope. For HAT-P-50 we also obtained follow-up photometry with the CCD imager on the Byrne Observatory at Sedgwick (BOS) 0.8m telescope, located at Sedgwick Reserve in Santa Ynez Valley, CA, and operated by the Las Cumbres Observatory Global Telescope institute (LCOGT). HAT-P-50 was observed with HAT-10/G316 on 2008 Nov-2009 May, with HAT-5/G364 on 2009 May, with HAT-9/G364 on 2008 Dec-2009 May, with BOS on 2012 Feb 15, on 2012 Feb 21 and on 2012 Apr 08, and with Keplercam on 2012 Feb 18, on 2012 Nov 28, on 2012 Dec 23, on 2013 Jan 14, and on 2013 Jan 17. HAT-P-51 was observed with HAT-6/G164 on 2007 Sep-2008 Feb, with HAT-9/G164 on 2007 Sep-2008 Feb, with HAT-10/G165 on 2010 Sep-2011 Jan, with HAT-5/G165 on 2010 Nov-2011 Feb, with HAT-8/G165 on 2010 Nov-2011 Feb, with HAT-6/G209 on 2010 Nov-2011 Feb, with HAT-9/G209 on 2010 Nov-2011 Feb, with HAT-7/G210 on 2010 Nov-2011 Jan, and with Keplercam on 2011 Oct 21, on 2012 Jan 05, on 2012 Oct 05, on 2012 Oct 26, and on 2012 Nov 12. HAT-P-52 was observed with HAT-5/G212 on 2010 Sep-Nov, with HAT-8/G212 on 2010 Aug-Nov, and with Keplercam on 2010 Dec 23, on 2011 Sep 05, on 2011 Sep 27, on 2011 Nov 21, and on 2012 Jan 07. HAT-P-53 was observed with HAT-6/G164 on 2007 Sep-2008 Feb, with HAT-9/G164 on 2007 Sep-2008 Feb, with

  19. Engineering assessment of inactive uranium mill tailings: Mexican Hat Site, Mexican Hat, Utah

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-09-01

    Ford, Bacon and Davis Utah Inc. has reevaluated the Mexican Hat site in order to revise the March 1977 engineering assessment of the problems resulting from the existence of radioactive uranium mill tailings at Mexican Hat, Utah. This engineering assessment has included the preparation of topographic maps, the performance of core drillings and radiometric measurements sufficient to determine areas and volumes of tailings and radiation exposures of individuals and nearby populations, the investigations of site hydrology and meteorology, and the evaluation and costing of alternative corrective actions. Radon gas released from the 2.2 million tons of tailings at the Mexican Hat site constitutes the most significant environmental impact, although windblown tailings and external gamma radiation also are factors. The four alternative actions presented in this engineering assessment range from millsite decontamination with the addition of 3 m of stabilization cover material to removal of the tailings to remote disposal sites and decontamination of the tailings site. Cost estimates for the four options range from about $15,200,000 for stabilization in place, to about $45,500,000 for disposal at a distance of about 16 mi. Three principal alternatives for the reprocessing of the Mexican Hat tailings were examined: heap leaching; treatment at an existing mill; and reprocessing at a new conventional mill constructed for tailings reprocessing. The cost of the uranium recovered would be about $115/lb of U/sub 3/O/sub 8/ whether by heap leach or conventional plant processes. The spot market price for uranium was $25/lb early in 1981. Reprocessing the Mexican Hat tailings for uranium recovery is not economically attractive under present conditions.

  20. Engineering assessment of inactive uranium mill tailings: Mexican Hat Site, Mexican Hat, Utah

    International Nuclear Information System (INIS)

    Ford, Bacon and Davis Utah Inc. has reevaluated the Mexican Hat site in order to revise the March 1977 engineering assessment of the problems resulting from the existence of radioactive uranium mill tailings at Mexican Hat, Utah. This engineering assessment has included the preparation of topographic maps, the performance of core drillings and radiometric measurements sufficient to determine areas and volumes of tailings and radiation exposures of individuals and nearby populations, the investigations of site hydrology and meteorology, and the evaluation and costing of alternative corrective actions. Radon gas released from the 2.2 million tons of tailings at the Mexican Hat site constitutes the most significant environmental impact, although windblown tailings and external gamma radiation also are factors. The four alternative actions presented in this engineering assessment range from millsite decontamination with the addition of 3 m of stabilization cover material to removal of the tailings to remote disposal sites and decontamination of the tailings site. Cost estimates for the four options range from about $15,200,000 for stabilization in place, to about $45,500,000 for disposal at a distance of about 16 mi. Three principal alternatives for the reprocessing of the Mexican Hat tailings were examined: heap leaching; treatment at an existing mill; and reprocessing at a new conventional mill constructed for tailings reprocessing. The cost of the uranium recovered would be about $115/lb of U3O8 whether by heap leach or conventional plant processes. The spot market price for uranium was $25/lb early in 1981. Reprocessing the Mexican Hat tailings for uranium recovery is not economically attractive under present conditions

  1. WARM SPITZER PHOTOMETRY OF THREE HOT JUPITERS: HAT-P-3b, HAT-P-4b AND HAT-P-12b

    Energy Technology Data Exchange (ETDEWEB)

    Todorov, Kamen O. [Department of Astronomy and Astrophysics, Pennsylvania State University, University Park, PA 16802 (United States); Deming, Drake [Department of Astronomy, University of Maryland at College Park, College Park, MD 20742 (United States); Knutson, Heather A. [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States); Burrows, Adam [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Fortney, Jonathan J.; Laughlin, Gregory [Department of Astronomy and Astrophysics, University of California at Santa Cruz, Santa Cruz, CA 95064 (United States); Lewis, Nikole K. [Department of Earth, Atmospheric, and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Cowan, Nicolas B. [Department of Physics and Astronomy, Northwestern University, Evanston, IL 60208 (United States); Agol, Eric [Department of Astronomy, University of Washington, Box 351580, Seattle, WA 98195 (United States); Desert, Jean-Michel [Astronomy Department, California Institute of Technology, Pasadena, CA 91125 (United States); Sada, Pedro V. [Department of Physics and Mathematics, University of Monterrey, Monterrey (Mexico); Charbonneau, David [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Langton, Jonathan [Department of Physics, Principia College, Elsah, IL 62028 (United States); Showman, Adam P. [Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 85721 (United States)

    2013-06-20

    We present Warm Spitzer/IRAC secondary eclipse time series photometry of three short-period transiting exoplanets, HAT-P-3b, HAT-P-4b and HAT-P-12b, in both the available 3.6 and 4.5 {mu}m bands. HAT-P-3b and HAT-P-4b are Jupiter-mass objects orbiting an early K and an early G dwarf star, respectively. For HAT-P-3b we find eclipse depths of 0.112%+0.015%-0.030% (3.6 micron) and 0.094%+0.016%-0.009% (4.5 {mu}m). The HAT-P-4b values are 0.142%+0.014%-0.016% (3.6 micron) and 0.122%+0.012%-0.014% 4.5 {mu}m). The two planets' photometry is consistent with inefficient heat redistribution from their day to night sides (and low albedos), but it is inconclusive about possible temperature inversions in their atmospheres. HAT-P-12b is a Saturn-mass planet and is one of the coolest planets ever observed during secondary eclipse, along with the hot Neptune GJ 436b and the hot Saturn WASP-29b. We are able to place 3{sigma} upper limits on the secondary eclipse depth of HAT-P-12b in both wavelengths: <0.042% (3.6 {mu}m) and <0.085% (4.5 {mu}m). We discuss these results in the context of the Spitzer secondary eclipse measurements of GJ 436b and WASP-29b. It is possible that we do not detect the eclipses of HAT-P-12b due to high eccentricity, but find that weak planetary emission in these wavelengths is a more likely explanation. We place 3{sigma} upper limits on the |e cos {omega}| quantity (where e is eccentricity and {omega} is the argument of periapsis) for HAT-P-3b (<0.0081) and HAT-P-4b (<0.0042), based on the secondary eclipse timings.

  2. Stable transformation of an episomal protein-tagging shuttle vector in the piscine diplomonad Spironucleus vortens

    Directory of Open Access Journals (Sweden)

    Cronembold Daniela

    2008-04-01

    Full Text Available Abstract Background Diplomonads are common free-living inhabitants of anoxic aquatic environments and are also found as intestinal commensals or parasites of a wide variety of animals. Spironucleus vortens is a putatively commensal diplomonad of angelfish that grows to high cell densities in axenic culture. Genomic sequencing of S. vortens is in progress, yet little information is available regarding molecular and cellular aspects of S. vortens biology beyond descriptive ultrastructural studies. To facilitate the development of S. vortens as an additional diplomonad experimental model, we have constructed and stably transformed an episomal plasmid containing an enhanced green fluorescent protein (GFP tag, an AU1 epitope tag, and a tandem affinity purification (TAP tag. This construct also contains selectable antibiotic resistance markers for both S. vortens and E. coli. Results Stable transformants of S. vortens grew relatively rapidly (within 7 days after electroporation and were maintained under puromycin selection for over 6 months. We expressed the enhanced GFP variant, eGFP, under transcriptional control of the S. vortens histone H3 promoter, and visually confirmed diffuse GFP expression in over 50% of transformants. Next, we generated a histone H3::GFP fusion using the S. vortens conventional histone H3 gene and its native promoter. This construct was also highly expressed in the majority of S. vortens transformants, in which the H3::GFP fusion localized to the chromatin in both nuclei. Finally, we used fluorescence in situ hybridization (FISH of the episomal plasmid to show that the transformed plasmid localized to only one nucleus/cell and was present at roughly 10–20 copies per nucleus. Because S. vortens grows to high densities in laboratory culture, it is a feasible diplomonad from which to purify native protein complexes. Thus, we also included a TAP tag in the plasmid constructs to permit future tagging and subsequent purification

  3. UMTRA Project Site Observational Work Plan, Mexican Hat, Utah

    Energy Technology Data Exchange (ETDEWEB)

    1994-09-01

    Surface cleanup activities at the Mexican Hat UMTRA processing site are nearing completion. Ground Water contamination at the Mexican Hat site is a result of uranium milling operations. The extent of residual process water has been identified, and it is limited to the uppermost aquifer in the vicinity of the site. Deeper aquifers are not affected because of an upward hydraulic gradient and the presence of a confining unit (the deeper aquifers are protected by hydrogeologic isolation). The uppermost unit is returning to its pre-milling, mainly unsaturated state. The unit that contains the contaminated water is not a ground water resource because it qualifies as Class III (limited use) based on limited yield. Ground water in the uppermost unit is currently not used and is not anticipated to be used as a ground water resource. The nearby San Juan River and a converted oil exploration well provide all of the water needs for the area. There are no current threats to human health or livestock; and, because the zone of contamination does not represent a ground water resource, none are anticipated in the future. There are, however, seeps where contaminated water is exposed at land surface. The seeps create potential exposure pathways for plants and wildlife. It is not known at this time if there is a risk to the environment. Additional investigations are needed and are described in this document to confirm the presence or absence of potential environmental risks. Additional hydrogeologic investigations are not required. The proposed ground water compliance strategy for the site is no remediation, because the ground water in the uppermost aquifer (which is also the zone of contamination) qualifies for supplemental standards based on Class III, limited yield, and because there are no threats to human health. Domestic and agricultural water is pumped from a deeper aquifer that is isolated from the contaminated zone.

  4. UMTRA Project Site Observational Work Plan, Mexican Hat, Utah

    International Nuclear Information System (INIS)

    Surface cleanup activities at the Mexican Hat UMTRA processing site are nearing completion. Ground Water contamination at the Mexican Hat site is a result of uranium milling operations. The extent of residual process water has been identified, and it is limited to the uppermost aquifer in the vicinity of the site. Deeper aquifers are not affected because of an upward hydraulic gradient and the presence of a confining unit (the deeper aquifers are protected by hydrogeologic isolation). The uppermost unit is returning to its pre-milling, mainly unsaturated state. The unit that contains the contaminated water is not a ground water resource because it qualifies as Class III (limited use) based on limited yield. Ground water in the uppermost unit is currently not used and is not anticipated to be used as a ground water resource. The nearby San Juan River and a converted oil exploration well provide all of the water needs for the area. There are no current threats to human health or livestock; and, because the zone of contamination does not represent a ground water resource, none are anticipated in the future. There are, however, seeps where contaminated water is exposed at land surface. The seeps create potential exposure pathways for plants and wildlife. It is not known at this time if there is a risk to the environment. Additional investigations are needed and are described in this document to confirm the presence or absence of potential environmental risks. Additional hydrogeologic investigations are not required. The proposed ground water compliance strategy for the site is no remediation, because the ground water in the uppermost aquifer (which is also the zone of contamination) qualifies for supplemental standards based on Class III, limited yield, and because there are no threats to human health. Domestic and agricultural water is pumped from a deeper aquifer that is isolated from the contaminated zone

  5. Monitoring of BTX by passive sampling in Hat Yai

    Directory of Open Access Journals (Sweden)

    Proespichaya Kanatharana

    2004-02-01

    Full Text Available Laboratory-built passive samplers were used for monitoring of trace benzene, toluene and xylene (BTX in Hat Yai from 28 July to 12 August, 2003. Sampler bottles contained activated Tenax TA 60/80 meshand a lab-built thermal well were developed and evaluated for the sampling and analysis of BTX. The sampling was carried out for two weeks before the passive samplers were thermally desorbed, trapped ina sampling loop by a laboratory built purge and trap system and analysed by gas chromatography (GC equipped with a flame ionization detector. After optimization and calibration, the developed method showed high selectivity, a good sensitivity with detection limits for BTX of 0.8, 1.1 and 13.0 µg/m3 respectively and an acceptable precision. Ambient BTX measurements were conducted at many monitoring site i.e. hot spots (high exposure, residential areas/work places (common exposure and park (low exposure. The concentration at hot spots range from 3.2 to 5.4 µg/m3 for benzene, 38.0 to 80.3 µg/m3 for toluene and 29.7 to 66.7 µg/m3 for xylene.The low BTX were found at the city periphery (Tesco-Lotus billboard sampling stations, roof level and in Hat Yai Municipal Park but no absolute background concentration could be defined. The monitoring results showed that at higher level from the street surface, the level of BTX tended to decrease and the BTX pollution built up along a street canyon (Sanehanuson Road according to the wind direction. The highest BTX were found at the underground parking, 23.5 725.1 and 267.9 µg/m3 respectively where both WHO guideline for Benzene (16.3 µg/m3 and Toluene (260 µg/m3 were exceeded.

  6. Genetic modification of cancer cells using non-viral, episomal S/MAR vectors for in vivo tumour modelling.

    Directory of Open Access Journals (Sweden)

    Orestis Argyros

    Full Text Available The development of genetically marked animal tumour xenografts is an area of ongoing research to enable easier and more reliable testing of cancer therapies. Genetically marked tumour models have a number of advantages over conventional tumour models, including the easy longitudinal monitoring of therapies and the reduced number of animals needed for trials. Several different methods have been used in previous studies to mark tumours genetically, however all have limitations, such as genotoxicity and other artifacts related to the usage of integrating viral vectors. Recently, we have generated an episomally maintained plasmid DNA (pDNA expression system based on Scaffold/Matrix Attachment Region (S/MAR, which permits long-term luciferase transgene expression in the mouse liver. Here we describe a further usage of this pDNA vector with the human Ubiquitin C promoter to create stably transfected human hepatoma (Huh7 and human Pancreatic Carcinoma (MIA-PaCa2 cell lines, which were delivered into "immune deficient" mice and monitored longitudinally over time using a bioluminometer. Both cell lines revealed sustained episomal long-term luciferase expression and formation of a tumour showing the pathological characteristics of hepatocellular carcinoma (HCC and pancreatic carcinoma (PaCa, respectively. This is the first demonstration that a pDNA vector can confer sustained episomal luciferase transgene expression in various mouse tumour models and can thus be readily utilised to follow tumour formation without interfering with the cellular genome.

  7. Utilization of a thermosensitive episome bearing transposon TN10 to isolate Hfr donor strains of Erwinia carotovora subsp. chrysanthemi.

    Science.gov (United States)

    Kotoujansky, A; Lemattre, M; Boistard, P

    1982-04-01

    A thermosensitive episome bearing the transposon Tn10, F(Ts)::Tn10 Lac+, has been successfully transferred from Escherichia coli to several wild strains of the enterobacteria Erwinia carotovora subsp. chrysanthemi, which are pathogenic on Saintpaulia ionantha. In one of these strains, all of the characters controlled by this episome (Lac+, Tetr, Tra+) were expressed, and its replication was stopped at 40 degrees C and above. At 30 degrees C, the episome was easily transferred between strains derived from E. carotovora subsp. chrysanthemi 3937j and to E coli. Hfr donor strains were obtained from a F' strain of 3937j by selecting clones which grew at 40 degrees C on plates containing tetracycline. One of these strains, Hfrq, was examined in more detail: the characters Lac+ and Tetr were stabilized and did not segregate higher than its parental F' strain. The mating was most efficient at 37 degrees C on a membrane. Hfrq transferred its chromosome to recipient strains at high frequency and in a polarized fashion, as evidenced by the gradient of transfer frequencies, the kinetics of marker entry (in interrupted mating experiments), and the analysis of linkage between different markers. The chromosome of Hfrq was most probably transferred in the following sequence: origin...met...xyl...arg...ile...leu...thr...cys...pan...ura...gal...trp...his. ..pur... Moreover, this genetic transfer system proved to be efficient in strain construction. PMID:6277860

  8. Increased expression of the major cysteine proteinases by stable episomal transfection underlines the important role of EhCP5 for the pathogenicity of Entamoeba histolytica.

    Science.gov (United States)

    Tillack, Manuela; Nowak, Nicolas; Lotter, Hannelore; Bracha, Rivka; Mirelman, David; Tannich, Egbert; Bruchhaus, Iris

    2006-09-01

    The protozoan Entamoeba histolytica causes intestinal inflammation and liver abscess. Cysteine proteinases (CPs) have been proposed as important virulence factors for amoebiasis. To test the role of the various CPs for amoeba induced pathology, the three major enzymes of the parasite, namely EhCP1, EhCP2 and EhCP5 accounting for about 90% of total proteinase activity, were overexpressed by stable episomal transfection. Total CP activity of recombinant amoebae increased by three- to six-fold depending on the gene transfected. Interestingly, overexpression of the genes for EhCP1 or EhCP2 increased the activity of the corresponding enzyme only, whereas overexpression of the gene for EhCP5 increased the activity of all three enzymes, which is consistent with enzyme-converting activity of EhCP5. Cytopathic activity, measured by in vitro monolayer disruption, was dramatically increased in ehcp5-transfectants (five-fold) but showed only a modest increase in ehcp1- or ehcp2-transfectants (1.5-2-fold). In addition, overexpression of ehcp5 but not of ehcp1 or ehcp2 significantly increased amoebic liver abscess formation in laboratory animals. Moreover, transfection and overexpression of ehcp5 was able to compensate the reduction of in vivo pathogenicity in parasites, which have been silenced for the gene encoding the pore-forming protein amoebapore A. In summary, these results further support the important role of EhCP5 in E. histolytica pathogenicity.

  9. Immunodiagnosis of episomal Banana streak MY virus using polyclonal antibodies to an expressed putative coat protein.

    Science.gov (United States)

    Sharma, Susheel Kumar; Kumar, P Vignesh; Baranwal, Virendra Kumar

    2014-10-01

    A cryptic Badnavirus species complex, known as banana streak viruses (BSV) poses a serious threat to banana production and genetic improvement worldwide. Due to the presence of integrated BSV sequences in the banana genome, routine detection is largely based on serological and nucleo-serological diagnostic methods which require high titre specific polyclonal antiserum. Viral structural proteins like coat protein (CP) are the best target for in vitro expression, to be used as antigen for antiserum production. However, in badnaviruses precise CP sequences are not known. In this study, two putative CP coding regions (p48 and p37) of Banana streak MY virus (BSMYV) were identified in silico by comparison with caulimoviruses, retroviruses and Rice tungro bacilliform virus. The putative CP coding region (p37) was in vitro expressed in pMAL system and affinity purified. The purified fusion protein was used as antigen for raising polyclonal antiserum in rabbit. The specificity of antiserum was confirmed in Western blots, immunosorbent electron microscopy (ISEM) and antigen coated plate-enzyme linked immunosorbent assay (ACP-ELISA). The antiserum (1:2000) was successfully used in ACP-ELISA for specific detection of BSMYV infection in field and tissue culture raised banana plants. The antiserum was also utilized in immuno-capture PCR (IC-PCR) based indexing of episomal BSMYV infection. This is the first report of in silico identification of putative CP region of BSMYV, production of polyclonal antiserum against recombinant p37 and its successful use in immunodetection.

  10. Remedial Action Plan for the codisposal and stabilization of the Monument Valley and Mexican Hat uranium mill tailings at Mexican Hat, Utah

    International Nuclear Information System (INIS)

    This document is a revision of the original Mexiacan Hat Remedial Action Plan (RAP) and RAP Modification submitted in July 1988 and January 1989, respectively, along with updated design documents. This RAP has been developed to serve a two-fold purpose. It presents the activities proposed by the Department of Energy (DOE) to accomplish long-term stabilization and control of the residual radioactive materials (RRM) from Monument Valley, Arizona, and Mexican Hat, Utah, at the Mexican Hat disposal site. It also serves to document the concurrence of both the Navajo Nation and the Nuclear Regulatory Commission (NRC) in the remedial action. This agreement, upon execution by DOE and the Navajo Nation and concurrence by the NRC, becomes Appendix B of the Cooperative Agreement. This document has been structured to provide a comprehensive understanding of the remedial action proposed for the Monument Valley and Mexican Hat sites. It includes specific design and construction requirements for the remedial action. Pertinent information and data are included with reference given to the supporting documents. Section 2.0 presents the EPA standards, including a discussion of their objectives. Section 3. 0 summarizes the present site characteristics and provides a definition of site-specific problems. Section 4.0 is the site design for the proposed action. Section 5.0 presents the water resources protection strategy. Section 6.0 summarizes the plan for ensuring health and safety protection for the surrounding community and the on- site workers. Section 7.0 lists the responsibilities of the project participants. Section 8.0 describes the features of the long-term surveillance and maintenance plan

  11. Environmental Assessment of Remedial Action at the Mexican Hat Uranium Mill Tailings Site, Mexican Hat, Utah

    OpenAIRE

    U.S. Department of Energy

    1987-01-01

    This document assesses the environmental impacts of the proposed remedial action at the Mexican Hat uranium mill tailings site located on the Navajo Reservation in southern Utah. The site covers 235 acres and contains 69 acres of tailings and several of the original mill structures. The Uranium Mill Tailings Radiation Control Act (UMTRCA) of 1978, Public Law 95-604 (PL95-604), authorized the U.S. Department of Energy to clean up the site to reduce the potential health impacts associated wit...

  12. Ground-based transit observations of the HAT-P-18, HAT-P-19, HAT-P-27/WASP-40 and WASP-21 systems

    CERN Document Server

    Seeliger, M; Errmann, R; Richter, S; Ohlert, J M; Chen, W P; Guo, J K; Göğüş, E; Güver, T; Aydın, B; Mottola, S; Hellmich, S; Fernandez, M; Aceituno, F J; Dimitrov, D; Kjurkchieva, D; Jensen, E; Cohen, D; Kundra, E; Pribulla, T; Vaňko, M; Budaj, J; Mallonn, M; Wu, Z Y; Zhou, X; Raetz, St; Adam, C; Schmidt, T O B; Ide, A; Mugrauer, M; Marschall, L; Hackstein, M; Chini, R; Haas, M; Ak, T; Güzel, E; Özdönmez, A; Ginski, C; Marka, C; Schmidt, J G; Dincel, B; Werner, K; Dathe, A; Greif, J; Wolf, V; Buder, S; Pannicke, A; Puchalski, D; Neuhäuser, R

    2015-01-01

    As part of our ongoing effort to investigate transit timing variations (TTVs) of known exoplanets, we monitored transits of the four exoplanets HAT-P-18b, HAT-P-19b, HAT-P-27b/WASP-40b and WASP-21b. All of them are suspected to show TTVs due to the known properties of their host systems based on the respective discovery papers. During the past three years 46 transit observations were carried out, mostly using telescopes of the Young Exoplanet Transit Initiative. The analyses are used to refine the systems orbital parameters. In all cases we found no hints for significant TTVs, or changes in the system parameters inclination, fractional stellar radius and planet to star radius ratio. However, comparing our results with those available in the literature shows that we can confirm the already published values.

  13. pEPito: a significantly improved non-viral episomal expression vector for mammalian cells

    Directory of Open Access Journals (Sweden)

    Ogris Manfred

    2010-03-01

    Full Text Available Abstract Background The episomal replication of the prototype vector pEPI-1 depends on a transcription unit starting from the constitutively expressed Cytomegalovirus immediate early promoter (CMV-IEP and directed into a 2000 bp long matrix attachment region sequence (MARS derived from the human β-interferon gene. The original pEPI-1 vector contains two mammalian transcription units and a total of 305 CpG islands, which are located predominantly within the vector elements necessary for bacterial propagation and known to be counterproductive for persistent long-term transgene expression. Results Here, we report the development of a novel vector pEPito, which is derived from the pEPI-1 plasmid replicon but has considerably improved efficacy both in vitro and in vivo. The pEPito vector is significantly reduced in size, contains only one transcription unit and 60% less CpG motives in comparison to pEPI-1. It exhibits major advantages compared to the original pEPI-1 plasmid, including higher transgene expression levels and increased colony-forming efficiencies in vitro, as well as more persistent transgene expression profiles in vivo. The performance of pEPito-based vectors was further improved by replacing the CMV-IEP with the human CMV enhancer/human elongation factor 1 alpha promoter (hCMV/EF1P element that is known to be less affected by epigenetic silencing events. Conclusions The novel vector pEPito can be considered suitable as an improved vector for biotechnological applications in vitro and for non-viral gene delivery in vivo.

  14. Radiologic characterization of the Mexican Hat, Utah, uranium mill tailings remedial action site: Appendix D, Addenda D1--D7

    Energy Technology Data Exchange (ETDEWEB)

    Ludlam, J.R.

    1985-01-01

    This radiologic characterization of the inactive uranium millsite at Mexican Hat, Utah, was conducted by Bendix Field Engineering Corporation foe the US Department of Energy (DOE), Grand Junction Project Office, in response to and in accord with a Statement of Work prepared by the DOE Uranium Mill tailings Remedial Action Project (UMTRAP) Technical Assistance Contractor, Jacobs Engineering Group, Inc. the objective of this project was to determine the horizontal and vertical extent of contamination that exceeds the US Environmental Protection Agency (EPA) standards at the Mexican Hat site. The data presented in this report are required for characterization of the areas adjacent to the Mexican Hat tailings piles and for the subsequent design of cleanup activities. Some on-pile sampling was required to determine the depth of the 15-pCi/g Ra-226 interface in an area where wind and water erosion has taken place.

  15. Kepler Photometry Of HAT-P-11: Starspots And Spin-orbit Misalignment

    Science.gov (United States)

    Sanchis Ojeda, Roberto; Winn, J.

    2011-09-01

    I will present the analysis of 26 light curves of HAT-P-11 obtained with the Kepler satellite over 4 months. The light curves show spot-crossing anomalies, which are used to demonstrate that the stellar rotation and planetary orbit are misaligned by 90 +/- 23 degrees. This method of measuring spin-orbit alignment is purely photometric and is therefore complementary to the spectroscopic Rossiter-McLaughlin effect. Furthermore this new technique delivers the three-dimensional spin-orbit angle rather than the sky projection. For HAT-P-11 the analysis also shows that star spots occur at certain preferred latitudes on the star, as is the case for the Sun. We expect that these preferred latitudes will migrate toward the stellar equator over the years, in analogy with the "butterfly diagram" observed for sunspots. Thus, data from an extended Kepler mission will allow for a new and powerful probe of starspot activity cycles.

  16. HATS-25b through HATS-30b: A Half–dozen New Inflated Transiting Hot Jupiters from the HATSouth Survey

    Science.gov (United States)

    Espinoza, N.; Bayliss, D.; Hartman, J. D.; Bakos, G. Á.; Jordán, A.; Zhou, G.; Mancini, L.; Brahm, R.; Ciceri, S.; Bhatti, W.; Csubry, Z.; Rabus, M.; Penev, K.; Bento, J.; de Val-Borro, M.; Henning, T.; Schmidt, B.; Suc, V.; Wright, D. J.; Tinney, C. G.; Tan, T. G.; Noyes, R.

    2016-10-01

    We report six new inflated hot Jupiters (HATS-25b through HATS-30b) discovered using the HATSouth global network of automated telescopes. The planets orbit stars with V magnitudes in the range of ∼12–14 and have masses in the largely populated 0.5{M}J{--}0.7{M}J region of parameter space but span a wide variety of radii, from 1.17{R}J to 1.75{R}J. HATS-25b, HATS-28b, HATS-29b, and HATS-30b are typical inflated hot Jupiters ({R}p=1.17{--}1.26{R}J) orbiting G–type stars in short period (P = 3.2-4.6 days) orbits. However, HATS-26b ({R}p=1.75{R}J, P=3.3024 days) and HATS-27b ({R}p=1.50{R}J, P=4.6370 days) stand out as highly inflated planets orbiting slightly evolved F stars just after and in the turn–off points, respectively, which are among the least dense hot Jupiters, with densities of 0.153 {{g}} {{cm}}-3 and 0.180 {{g}} {{cm}}-3, respectively. All the presented exoplanets but HATS-27b are good targets for future atmospheric characterization studies, while HATS-27b is a prime target for Rossiter—McLaughlin monitoring in order to determine its spin–orbit alignment given the brightness (V = 12.8) and stellar rotational velocity (v\\sin i≈ 9.3 km s‑1) of the host star. These discoveries significantly increase the number of inflated hot Jupiters known, contributing to our understanding of the mechanism(s) responsible for hot Jupiter inflation. The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia Universidad Católica de Chile (PUC). The station at Las Campanas Observatory (LCO) of the Carnegie Institute is operated by PU in conjunction with PUC, the station at the High Energy Spectroscopic Survey (H.E.S.S.) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU. Based in part on observations made with the MPG 2.2 m Telescope at the ESO

  17. Environmental assessment of remedial action at the Mexican Hat uranium mill tailings site, Mexican Hat, Utah

    International Nuclear Information System (INIS)

    This document assesses the environmental impacts of the proposed remedial action at the Mexican Hat uranium mill tailings site located on the Navajo Reservation in southern Utah. The site covers 235 acres and contains 69 acres of tailings and several of the original mill structures. Remedial action must be performed in accordance with standards and with the concurrence of the US Nuclear Regulatory Commission and the Navajo Nation. The proposed action is to stabilize the tailings within the present tailings site by consolidating the tailings and associated contaminated soils into a recontoured pile. A radon barrier of compacted earth would be constructed over the pile, and various erosion control measures would be taken to assure the long-term stability of the pile. The no action alternative is also assessed in this document. 240 refs., 12 figs., 20 tabs

  18. HATS-7b: A Hot Super Neptune Transiting a Quiet K Dwarf Star

    CERN Document Server

    Bakos, G Á; Bayliss, D; Hartman, J D; Zhou, G; Brahm, R; Mancini, L; deVal-Borro, M; Bhatti, W; Jordán, A; Rabus, M; Espinoza, N; Csubry, Z; Howard, A W; Fulton, B J; Buchhave, L A; Ciceri, S; Henning, T; Schmidt, B; Isaacson, H; Noyes, R W; Marcy, G W; Suc, V; Howe, A R; Burrows, A S; Lázár, J; Papp, I; Sári, P

    2015-01-01

    We report the discovery by the HATSouth network of HATS-7b, a transiting Super-Neptune with a mass of 0.120+/-0.012 M_Jup, a radius of 0.563+0.046-0.034 R_Jup, and an orbital period of 3.1853 days. The host star is a moderately bright (V = 13.340+/-0.010 mag, K_S = 10.976+/-0.026 mag) K dwarf star with a mass of 0.849+/-0.027 M_Sun, a radius of 0.815+0.049-0.035 R_Sun, and a metallicity of [Fe/H]= +0.250+/-0.080. The star is photometrically quiet to within the precision of the HATSouth measurements, has low RV jitter, and shows no evidence for chromospheric activity in its spectrum. HATS-7b is the second smallest radius planet discovered by a wide-field ground-based transit survey, and one of only a handful of Neptune-size planets with mass and radius determined to 10% precision. Theoretical modeling of HATS-7b yields a hydrogen-helium fraction of 18+/-4% (rock-iron core and H2-He envelope), or 9+/-4% (ice core and H2-He envelope), i.e.it has a composition broadly similar to that of Uranus and Neptune, and ve...

  19. A Sequence-Independent Strategy for Amplification and Characterisation of Episomal Badnavirus Sequences Reveals Three Previously Uncharacterised Yam Badnaviruses.

    Science.gov (United States)

    Bömer, Moritz; Turaki, Aliyu A; Silva, Gonçalo; Kumar, P Lava; Seal, Susan E

    2016-01-01

    Yam (Dioscorea spp.) plants are potentially hosts to a diverse range of badnavirus species (genus Badnavirus, family Caulimoviridae), but their detection is complicated by the existence of integrated badnavirus sequences in some yam genomes. To date, only two badnavirus genomes have been characterised, namely, Dioscorea bacilliform AL virus (DBALV) and Dioscorea bacilliform SN virus (DBSNV). A further 10 tentative species in yam have been described based on their partial reverse transcriptase (RT)-ribonuclease H (RNaseH) sequences, generically referred to here as Dioscorea bacilliform viruses (DBVs). Further characterisation of DBV species is necessary to determine which represent episomal viruses and which are only present as integrated badnavirus sequences in some yam genomes. In this study, a sequence-independent multiply-primed rolling circle amplification (RCA) method was evaluated for selective amplification of episomal DBV genomes. This resulted in the identification and characterisation of nine complete genomic sequences (7.4-7.7 kbp) of existing and previously undescribed DBV phylogenetic groups from Dioscorea alata and Dioscorea rotundata accessions. These new yam badnavirus genomes expand our understanding of the diversity and genomic organisation of DBVs, and assist the development of improved diagnostic tools. Our findings also suggest that mixed badnavirus infections occur relatively often in West African yam germplasm. PMID:27399761

  20. Vector Boson Jets with BlackHat and Sherpa

    Energy Technology Data Exchange (ETDEWEB)

    Berger, C.F.; /MIT, LNS; Bern, Z.; /UCLA; Dixon, Lance J.; /SLAC; Cordero, F.Febres; /Simon Bolivar U.; Forde, D.; /CERN /NIKHEF, Amsterdam; Gleisberg, T.; /SLAC; Ita, H.; /UCLA; Kosower, D.A.; /Saclay, SPhT; Maitre, D.; /Durham U.

    2010-08-25

    We review recent NLO QCD results for W, Z + 3-jet production at hadron colliders, computing using BlackHat and SHERPA, and including also some new results for Z + 3-jet production for the LHC at 7 TeV. We report new progress towards the NLO cross section for W + 4-jet production. In particular, we show that the virtual matrix elements produced by BlackHat are numerically stable. We also show that with an improved integrator and tree-level matrix elements from BlackHat, SHERPA produces well-behaved real-emission contributions. As an illustration, we present the real-emission contributions - including dipole-subtraction terms - to the p{sub T} distribution of the fourth jet, for a single subprocess with the maximum number of gluons.

  1. The long duration flight of the TopHat experiment

    DEFF Research Database (Denmark)

    Silverberg, R. F.; Aguirre, J.; Bezaire, J.;

    2003-01-01

    The TopHat instrument was designed to operate on the top of a high altitude balloon. From this location, the experiment could efficiently observe using a clean beam with extremely low contamination from the far side lobes of the instrument beam. The experiment was designed to scan a large portion...... detectors operating at ~250mK. Here, we report on the flight of the TopHat experiment over Antarctica in January, 2001 and describe the scientific goals, the operation, and in-flight performance....

  2. Social factors in occupational health: a history of hard hats.

    Science.gov (United States)

    Rosenberg, Beth; Levenstein, Charles

    2010-01-01

    Personal protective equipment (PPE) is the least desirable way to ensure workplace safety, and it is difficult to use consistently. Hard hats are different; they have cachet and are often worn even when they are not required. We investigated the history of this personal protective equipment to see if there were any lessons that could be applied to other forms of PPE. We learned that what makes hard hats special are social factors that are specific to a certain time and place. The importance of social factors illuminates the requirement that cultural and social norms of workers be included in any kind of worker safety and health training.

  3. HAT AVERAGE MULTIRESOLUTION WITH ERROR CONTROL IN 2-D

    Institute of Scientific and Technical Information of China (English)

    Sergio Amat

    2004-01-01

    Multiresolution representations of data are a powerful tool in data compression. For a proper adaptation to the singularities, it is crucial to develop nonlinear methods which are not based on tensor product. The hat average framework permets develop adapted schemes for all types of singularities. In contrast with the wavelet framework these representations cannot be considered as a change of basis, and the stability theory requires different considerations. In this paper, non separable two-dimensional hat average multiresolution processing algorithms that ensure stability are introduced. Explicit error bounds are presented.

  4. Exoplanet Transits Registered at the Universidad de Monterrey Observatory. Part I: HAT-P-12b, HAT-P-13b, HAT-P-16b, HAT-P-23b and WASP-10b

    CERN Document Server

    Sada, Pedro V

    2016-01-01

    Forty transits of the exoplanets HAT-P-12b, HAT-P-13b, HAT-P-16b, HAT-P-23b and WASP-10b were recorded with the 0.36m telescope at the Universidad de Monterrey Observatory. The images were captured with a standard Johnson-Cousins Rc and Ic and Sloan z' filters and processed to obtain individual light curves of the events. These light curves were successfully combined for each system to obtain a resulting one of higher quality, but with a slightly larger time sampling rate. A reduction by a factor of about four in per-point scatter was typically achieved, resulting in combined light curves with a scatter of ~1 mmag. The noise characteristics of the combined light curves were verified by comparing Allan variance plots of the residuals. The combined light curves for each system, along with radial velocity measurements from the literature when available, were modeled using a Monte Carlo method to obtain the essential parameters that characterize the systems. Our results for all these systems confirm the derived t...

  5. The "Burgundian" hat from Herjolfsnes, Greenland: new discoveries, new dates

    DEFF Research Database (Denmark)

    Smith, Michèle Hayeur; Arneborg, Jette; Smith, Kevin

    2016-01-01

    of the Greenland Norse colony but also its enduring cultural links with continental European fashions, following a comment to this effect published by Nørlund himself. In 1996, the hat was dated to the early fourteenth century by Arneborg, a century earlier than Nørlund’s dating, based on stylistic comparisons...

  6. Dr. Edward de Bono's Six Thinking Hats and Numeracy

    Science.gov (United States)

    Paterson, Anne

    2006-01-01

    In education, the term "metacognition" describes thinking about thinking. Within mathematics, the term "metacomputation" describes thinking about computational methods and tools. This article shows how Dr. Edward de Bono's Six Thinking Hats can be used to demonstrate metacognition and metacomputation in the primary classroom. The article suggests…

  7. Human glioblastoma cells persistently infected with simian virus 40 carry nondefective episomal viral DNA and acquire the transformed phenotype and numerous chromosomal abnormalities.

    Science.gov (United States)

    Norkin, L C; Steinberg, V I; Kosz-Vnenchak, M

    1985-02-01

    A stable, persistent infection of A172 human glioblastoma cells with simian virus 40 (SV40) was readily established after infection at an input of 450 PFU per cell. Only 11% of the cells were initially susceptible to SV40, as shown by indirect immunofluorescent staining for the SV40 T antigen at 48 h. However, all cells produced T antigen by week 11. In contrast, viral capsid proteins were made in only about 1% of the cells in the established carrier system. Weekly viral yields ranged between 10(4) and 10(6) PFU/ml. Most of the capsid protein-producing cells contained enormous aberrant (lobulated or multiple) nuclei. Persistent viral DNA appeared in an episomal or "free" state exclusively in Southern blots and was indistinguishable from standard SV40 DNA by restriction analysis. Viral autointerference activity was not detected, and yield reduction assays did not indicate defective interfering particle activity, further implying that variant viruses were not a factor in this carrier system. Interferon was also not a factor in the system, as shown by direct challenge with vesicular stomatitis virus. Persistent infection resulted in cellular growth changes (enhanced saturation density and plating efficiency) characteristic of SV40 transformation. Persistent infection also led to an increased frequency of cytogenetic effects. These included sister chromatid exchanges, a variety of chromosomal abnormalities (ring chromosomes, acentric fragments, breaks, and gaps), and an increase in the chromosome number. Nevertheless, the persistently infected cells continued to display a bipolar glial cell-like morphology with extensive process extension and intercellular contacts.

  8. Ectopic expression of AID in a non-B cell line triggers A:T and G:C point mutations in non-replicating episomal vectors.

    Directory of Open Access Journals (Sweden)

    Tihana Jovanic

    Full Text Available Somatic hypermutation (SHM of immunoglobulin genes is currently viewed as a two step process initiated by the deamination of deoxycytidine (C to deoxyuridine (U, catalysed by the activation induced deaminase (AID. Phase 1 mutations arise from DNA replication across the uracil residue or the abasic site, generated by the uracil-DNA glycosylase, yielding transitions or transversions at G:C pairs. Phase 2 mutations result from the recognition of the U:G mismatch by the Msh2/Msh6 complex (MutS Homologue, followed by the excision of the mismatched nucleotide and the repair, by the low fidelity DNA polymerase eta, of the gap generated by the exonuclease I. These mutations are mainly focused at A:T pairs. Whereas in activated B cells both G:C and A:T pairs are equally targeted, ectopic expression of AID was shown to trigger only G:C mutations on a stably integrated reporter gene. Here we show that when using non-replicative episomal vectors containing a GFP gene, inactivated by the introduction of stop codons at various positions, a high level of EGFP positive cells was obtained after transient expression in Jurkat cells constitutively expressing AID. We show that mutations at G:C and A:T pairs are produced. EGFP positive cells are obtained in the absence of vector replication demonstrating that the mutations are dependent only on the mismatch repair (MMR pathway. This implies that the generation of phase 1 mutations is not a prerequisite for the expression of phase 2 mutations.

  9. HAT-P-50b, HAT-P-51b, HAT-P-52b, and HAT-P-53b: Three Transiting Hot Jupiters and a Transiting Hot Saturn From the HATNet Survey

    CERN Document Server

    Hartman, Joel D; Bakos, Gáspár Á; Bieryla, Allyson; Kovács, Géza; Latham, David W; Csubry, Zoltan; de Val-Borro, Miguel; Penev, Kaloyan; Buchhave, Lars A; Torres, Guillermo; Howard, Andrew W; Marcy, Geoff W; Johnson, John A; Isaacson, Howard; Sato, Bun'ei; Boisse, Isabelle; Falco, Emilio; Everett, Mark E; Szklenar, Tamas; Fulton, Benjamin J; Shporer, Avi; Kovács, Tamas; Hansen, Terese; Béky, Bence; Noyes, Robert W; Lázár, József; Papp, Istvan; Sári, Pál

    2015-01-01

    We report the discovery and characterization of four transiting exoplanets by the HATNet survey. The planet HAT-P-50b has a mass of 1.35 M_J and a radius of 1.29 R_J, and orbits a bright (V = 11.8 mag) M = 1.27 M_sun, R = 1.70 R_sun star every P = 3.1220 days. The planet HAT-P-51b has a mass of 0.31 M_J and a radius of 1.29 R_J, and orbits a V = 13.4 mag, M = 0.98 M_sun, R = 1.04 R_sun star with a period of P = 4.2180 days. The planet HAT-P-52b has a mass of 0.82 M_J and a radius of 1.01 R_J, and orbits a V = 14.1 mag, M = 0.89 M_sun, R = 0.89 R_sun star with a period of P = 2.7536 days. The planet HAT-P-53b has a mass of 1.48 M_J and a radius of 1.32 R_J, and orbits a V = 13.7 mag, M = 1.09 M_sun, R = 1.21 R_sun star with a period of P = 1.9616 days. All four planets are consistent with having circular orbits and have masses and radii measured to better than 10% precision. The low stellar jitter and favorable R_P/R_star ratio for HAT-P-51 make it a promising target for measuring the Rossiter-McLaughlin effec...

  10. HATS-9b AND HATS-10b: TWO COMPACT HOT JUPITERS IN FIELD 7 OF THE K2 MISSION

    CERN Document Server

    Brahm, R; Hartman, J D; Bakos, G Á; Bayliss, D; Penev, K; Zhou, G; Ciceri, S; Rabus, M; Espinoza, N; Mancini, L; de Val-Borro, M; Bhatti, W; Sato, B; Tan, T G; Csubry, Z; Buchhave, L; Henning, T; Schmidt, B; Suc, V; Noyes, R W; Papp, I; Lázár, J; Sári, P

    2015-01-01

    We report the discovery of two transiting extrasolar planets by the HATSouth survey. HATS-9b orbits an old (10.8 $\\pm$ 1.5 Gyr) V=13.3 G dwarf star, with a period P = 1.9153 d. The host star has a mass of 1.03 M$_{\\odot}$, radius of 1.503 R$_\\odot$ and effective temperature 5366 $\\pm$ 70 K. The planetary companion has a mass of 0.837 M$_J$, and radius of 1.065 R$_J$ yielding a mean density of 0.85 g cm$^{-3}$ . HATS-10b orbits a V=13.1 G dwarf star, with a period P = 3.3128 d. The host star has a mass of 1.1 M$_\\odot$, radius of 1.11 R$_\\odot$ and effective temperature 5880 $\\pm$ 120 K. The planetary companion has a mass of 0.53 M$_J$, and radius of 0.97 R$_J$ yielding a mean density of 0.7 g cm$^{-3}$ . Both planets are compact in comparison with planets receiving similar irradiation from their host stars, and lie in the nominal coordinates of Field 7 of K2 but only HATS-9b falls on working silicon. Future characterisation of HATS-9b with the exquisite photometric precision of the Kepler telescope may provid...

  11. Structural basis of hAT transposon end recognition by Hermes, an octameric DNA transposase from Musca domestica.

    Science.gov (United States)

    Hickman, Alison B; Ewis, Hosam E; Li, Xianghong; Knapp, Joshua A; Laver, Thomas; Doss, Anna-Louise; Tolun, Gökhan; Steven, Alasdair C; Grishaev, Alexander; Bax, Ad; Atkinson, Peter W; Craig, Nancy L; Dyda, Fred

    2014-07-17

    Hermes is a member of the hAT transposon superfamily that has active representatives, including McClintock's archetypal Ac mobile genetic element, in many eukaryotic species. The crystal structure of the Hermes transposase-DNA complex reveals that Hermes forms an octameric ring organized as a tetramer of dimers. Although isolated dimers are active in vitro for all the chemical steps of transposition, only octamers are active in vivo. The octamer can provide not only multiple specific DNA-binding domains to recognize repeated subterminal sequences within the transposon ends, which are important for activity, but also multiple nonspecific DNA binding surfaces for target capture. The unusual assembly explains the basis of bipartite DNA recognition at hAT transposon ends, provides a rationale for transposon end asymmetry, and suggests how the avidity provided by multiple sites of interaction could allow a transposase to locate its transposon ends amidst a sea of chromosomal DNA. PMID:25036632

  12. Structural Basis for Transposon End Recognition by Hermes, an Octameric hAT DNA Transposase from Musca domestica

    Science.gov (United States)

    Hickman, Alison B.; Ewis, Hosam E.; Li, Xianghong; Knapp, Joshua A.; Laver, Thomas; Doss, Anna-Louise; Tolun, Gökhan; Steven, Alasdair C.; Grishaev, Alexander; Bax, Ad; Atkinson, Peter W.; Craig, Nancy L.; Dyda, Fred

    2014-01-01

    SUMMARY Hermes is a member of the hAT transposon superfamily which has active representatives, including McClintock's archetypal Ac mobile genetic element, in many eukaryotic species. The crystal structure of the Hermes transposase-DNA complex reveals that Hermes forms an octameric ring organized as a tetramer of dimers. While isolated dimers are active in vitro for all the chemical steps of transposition, only octamers are active in vivo. The octamer can provide not only multiple specific DNA-binding domains to recognize repeated subterminal sequences within the transposon ends, which are important for activity, but also multiple non-specific DNA binding surfaces for target capture. The unusual assembly explains the basis of bipartite DNA recognition at hAT transposon ends, provides a rationale for transposon end asymmetry, and suggests how the avidity provided by multiple sites of interaction could allow a transposase to locate its transposon ends amidst a sea of chromosomal DNA. PMID:25036632

  13. Einstein's $R^{\\hat{0} \\hat{0}}$ equation for non-relativistic sources derived from Einstein's inertial motion and the Newtonian law for relative acceleration

    CERN Document Server

    ,

    2016-01-01

    With Einstein's inertial motion (free-falling and non-rotating relative to gyroscopes), geodesics for non-relativistic particles can intersect repeatedly, allowing one to compute the space-time curvature $R^{\\hat{0} \\hat{0}}$ exactly. Einstein's $R^{\\hat{0} \\hat{0}}$ for strong gravitational fields and for relativistic source-matter is identical with the Newtonian expression for the relative radial acceleration of neighboring free-falling test-particles, spherically averaged.--- Einstein's field equations follow from Newtonian experiments, local Lorentz-covariance, and energy-momentum conservation combined with the Bianchi identity.

  14. Experimental studies on the axial crash behavior of aluminum foam-filled hat sections

    Institute of Scientific and Technical Information of China (English)

    WANG Qing-chun; FAN Zi-jie; GUI Liang-jin; WANG Zheng-hong; FU Zi-lai

    2006-01-01

    Drop hammer tests were carried out to study the axial crash behavior of aluminum foam-filled hat sections.First,the axial crash tests of the empty hat sections,aluminum foam and the aluminum foam-filled hat sections were carried out;then,based upon the test results,the axial crash behavior of the aluminum foam-filled hat sections were analyzed.It was found that aluminum foam filling can increase the energy absorption capacities of the hat sections.Compared with the non-filled structures,aluminum foamfilled structures were much more stable and needed less mass to absorb the specified energy.

  15. HATS-7b: A Hot Super Neptune Transiting a Quiet K Dwarf Star

    Science.gov (United States)

    Bakos, G. Á.; Penev, K.; Bayliss, D.; Hartman, J. D.; Zhou, G.; Brahm, R.; Mancini, L.; de Val-Borro, M.; Bhatti, W.; Jordán, A.; Rabus, M.; Espinoza, N.; Csubry, Z.; Howard, A. W.; Fulton, B. J.; Buchhave, L. A.; Ciceri, S.; Henning, T.; Schmidt, B.; Isaacson, H.; Noyes, R. W.; Marcy, G. W.; Suc, V.; Howe, A. R.; Burrows, A. S.; Lázár, J.; Papp, I.; Sári, P.

    2015-11-01

    We report the discovery by the HATSouth network of HATS-7b, a transiting Super-Neptune with a mass of 0.120 ± 0.012 {M}{{J}}, a radius of {0.563}-0.034+0.046 {R}{{J}}, and an orbital period of 3.1853 days. The host star is a moderately bright (V=13.340\\+/- 0.010 mag, {K}S=10.976\\+/- 0.026 mag) K dwarf star with a mass of 0.849 ± 0.027 {M}⊙ , a radius of {0.815}-0.035+0.049 {R}⊙ , and a metallicity of [{Fe}/{{H}}] =+0.250\\+/- 0.080. The star is photometrically quiet to within the precision of the HATSouth measurements, has low RV jitter, and shows no evidence for chromospheric activity in its spectrum. HATS-7b is the second smallest radius planet discovered by a wide-field ground-based transit survey, and one of only a handful of Neptune-size planets with mass and radius determined to 10% precision. Theoretical modeling of HATS-7b yields a hydrogen-helium fraction of 18 ± 4% (rock-iron core and H2-He envelope), or 9 ± 4% (ice core and H2-He envelope), i.e., it has a composition broadly similar to that of Uranus and Neptune, and very different from that of Saturn, which has 75% of its mass in H2-He. Based on a sample of transiting exoplanets with accurately (Mauna Kea, the MPG 2.2 m and ESO 3.6 m telescopes at the ESO Observatory in La Silla. This paper uses observations obtained with facilities of the Las Cumbres Observatory Global Telescope.

  16. Exoplanet HAT-P-11b Secondary Transit Observations

    Science.gov (United States)

    Barry, Richard K., Jr.

    2010-01-01

    We have conducted secondary eclipse observations of exoplanet HAT--11b, recently discovered by proposal G. Bakos and his colleagues. HAT-P-11b is the smallest transiting extrasolar planet yet found and one of only two known exo-Neptunes. We have observed the system at 3.6 microns for a period of 22 hours centered on the anticipated secondary eclipse time, to detect the eclipse and determine its phase. Once the secondary eclipse is located through analysis of the data, we will make a more focused series of observations in both the 3.6 and 4.5 micron bands to fully characterize it. HAT-P-1lb has a period of 4.8878 days, radius of 0.422 RJ, mass of 0.081 MJ and semi major axis 0.053 AU. Measurements of the secondary eclipse will clarify two key issues; 1) the planetary brightness temperature and the nature of its atmosphere, and 2) the eccentricity of its orbit, with implications for its dynamical evolution. A precise determination of the orbit phase for the secondary eclipse will also be of great utility for Kepler observations of this system at visible wavelengths.

  17. N=4 Sugawara construction on $sl(\\hat{2|1})$, $sl(\\hat{3})$ and mKdV-type superhierarchies

    CERN Document Server

    Ivanov, E; Toppan, F

    1999-01-01

    The local Sugawara constructions of the ``small'' N=4 SCA in terms of supercurrents of N=2 extensions of the affine $\\hat{sl(2|1)}$ and $\\hat{sl(3)}$ algebras are investigated. The associated super mKdV type hierarchies induced by N=4 SKdV ones are defined. In the $\\hat{sl(3)}$ case the existence of two inequivalent Sugawara constructions is found. The ``long'' one involves all the affine $\\hat{sl(3)}$ currents, while the ``short'' one deals only with those from the subalgebra $\\hat{sl(2)\\oplus u(1)}$. As a consequence, the hierarchies induced by the correspondence between ``small'' N=4 SCA and N=4 SKdV hierarchy. However, only the first hierarchy posseses genuine global N=4 supersymmetry. We discuss peculiarities of the realization of this N=4 supersymmetry on the affine supercurrents.

  18. The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF.

    Science.gov (United States)

    Sadler, Anthony J; Suliman, Bandar A; Yu, Liang; Yuan, Xiangliang; Wang, Die; Irving, Aaron T; Sarvestani, Soroush T; Banerjee, Ashish; Mansell, Ashley S; Liu, Jun-Ping; Gerondakis, Steve; Williams, Bryan R G; Xu, Dakang

    2015-01-01

    To date, the activities of protein kinases have formed the core of our understanding of cell signal transduction. Comprehension of the extent of protein acetylation has raised expectations that this alternate post-transcriptional modification will be shown to rival phosphorylation in its importance in mediating cellular responses. However, limited instances have been identified. Here we show that signalling from Toll-like or TNF-α receptors triggers the calcium/calmodulin-dependent protein kinase (CaMK2) to activate histone acetyltransferase-1 (HAT1), which then acetylates the transcriptional regulator PLZF. Acetylation of PLZF promotes the assembly of a repressor complex incorporating HDAC3 and the NF-κB p50 subunit that limits the NF-κB response. Accordingly, diminishing the activity of CaMK2, the expression levels of PLZF or HAT1, or mutating key residues that are covalently modified in PLZF and HAT1, curtails control of the production of inflammatory cytokines. These results identify a central role for acetylation in controlling the inflammatory NF-κB transcriptional programme. PMID:25865065

  19. Discovery of the secondary eclipse of HAT-P-11 b

    CERN Document Server

    Huber, K F; Schmitt, J H M M

    2016-01-01

    We report the detection of the secondary eclipse of HAT-P-11 b, a Neptune-sized planet orbiting an active K4 dwarf. Using all available short-cadence data of the Kepler mission, we derive refined planetary ephemeris increasing their precision by more than an order of magnitude. Our simultaneous primary and secondary transit modeling results in improved transit and orbital parameters. In particular, the precise timing of the secondary eclipse allows to pin down the orbital eccentricity to $0.26459_{-0.00048}^{+0.00069}$. The secondary eclipse depth of $6.09_{-1.11}^{+1.12}$ ppm corresponds to a $5.5\\sigma$ detection and results in a geometric albedo of $0.39\\pm0.07$ for HAT-P-11 b, close to Neptune's value, which may indicate further resemblances between these two bodies. Due to the substantial orbital eccentricity, the planetary equilibrium temperature is expected to change significantly with orbital position and ought to vary between $630^\\circ$ K and $950^\\circ$ K, depending on the details of heat redistrib...

  20. Lightning as a possible source of the radio emission on HAT-P-11b

    Science.gov (United States)

    Hodosán, G.; Rimmer, P. B.; Helling, Ch.

    2016-04-01

    Lightning induced radio emission has been observed on Solar System planets. There have been many attempts to observe exoplanets in the radio wavelength, however, no unequivocal detection has been reported. Lecavelier des Etangs et al. (2013, A&A, 552, A65) carried out radio transit observations of the exoplanet HAT-P-11b, and suggested that a small part of the radio flux can be attributed to the planet. In the current letter, we assume that this signal is real, and study if this radio emission could be caused by lightning in the atmosphere of the planet. We find that a lightning storm with 530 times larger flash densities than the Earth-storms with the largest lightning activity is needed to produce the observed signal from HAT-P-11b. The optical counterpart would nevertheless be undetectable with current technology. We show that HCN produced by lightning chemistry of such thunderstorms is observable 2-3 years after the storm, which produces signatures in the L (3.0μm - 4.0μm) and N (7.5μm - 14.5μm) infrared bands. We conclude that future, combined radio and infrared observations may lead to lightning detection on planets outside the Solar System.

  1. Lightning as a possible source of the radio emission on HAT-P-11b

    CERN Document Server

    Hodosán, Gabriella; Helling, Christiane

    2016-01-01

    Lightning induced radio emission has been observed on Solar System planets. There have been many attempts to observe exoplanets in the radio wavelength, however, no unequivocal detection has been reported. Lecavelier des Etangs et al. (2013, A&A, 552, A65) carried out radio transit observations of the exoplanet HAT-P-11b, and suggested that a small part of the radio flux can be attributed to the planet. In the current letter, we assume that this signal is real, and study if this radio emission could be caused by lightning in the atmosphere of the planet. We find that a lightning storm with 530 times larger flash densities than the Earth-storms with the largest lightning activity is needed to produce the observed signal from HAT-P-11b. The optical counterpart would nevertheless be undetectable with current technology. We show that HCN produced by lightning chemistry of such thunderstorms is observable 2-3 years after the storm, which produces signatures in the L ($3.0 \\mu{\\rm m}-4.0 \\mu$m) and N ($7.5 \\mu{...

  2. Is lightning a possible source of the radio emission on HAT-P-11b?

    Science.gov (United States)

    Hodosán, G.; Rimmer, P. B.; Helling, Ch.

    2016-09-01

    Lightning induced radio emission has been observed on Solar system planets. There have been many attempts to observe exoplanets in the radio wavelength, however, no unequivocal detection has been reported. Lecavelier des Etangs et al. carried out radio transit observations of the exoplanet HAT-P-11b, and suggested that a small part of the radio flux can be attributed to the planet. Here, we assume that this signal is real, and study if this radio emission could be caused by lightning with similar energetic properties like in the Solar system. We find that a lightning storm with 3.8 × 106 times larger flash densities than the Earth-storms with the largest lightning activity is needed to produce the observed signal from HAT-P-11b. The optical emission of such thunderstorm would be comparable to that of the host star. We show that HCN produced by lightning chemistry is observable 2-3 yr after the storm, which produces signatures in the L (3.0-4.0 μm) and N (7.5-14.5 μm) infrared bands. We conclude that it is unlikely that the observed radio signal was produced by lightning, however, future, combined radio and infrared observations may lead to lightning detection on planets outside the Solar system.

  3. A comparison of synthetic oligodeoxynucleotides, DNA fragments and AAV-1 for targeted episomal and chromosomal gene repair

    Directory of Open Access Journals (Sweden)

    Leclerc Xavier

    2009-04-01

    Full Text Available Abstract Background Current strategies for gene therapy of inherited diseases consist in adding functional copies of the gene that is defective. An attractive alternative to these approaches would be to correct the endogenous mutated gene in the affected individual. This study presents a quantitative comparison of the repair efficiency using different forms of donor nucleic acids, including synthetic DNA oligonucleotides, double stranded DNA fragments with sizes ranging from 200 to 2200 bp and sequences carried by a recombinant adeno-associated virus (rAAV-1. Evaluation of each gene repair strategy was carried out using two different reporter systems, a mutated eGFP gene or a dual construct with a functional eGFP and an inactive luciferase gene, in several different cell systems. Gene targeting events were scored either following transient co-transfection of reporter plasmids and donor DNAs, or in a system where a reporter construct was stably integrated into the chromosome. Results In both episomal and chromosomal assays, DNA fragments were more efficient at gene repair than oligonucleotides or rAAV-1. Furthermore, the gene targeting frequency could be significantly increased by using DNA repair stimulating drugs such as doxorubicin and phleomycin. Conclusion Our results show that it is possible to obtain repair frequencies of 1% of the transfected cell population under optimized transfection protocols when cells were pretreated with phleomycin using rAAV-1 and dsDNA fragments.

  4. Orta hat asimetrileri ve tedavi seçenekleri

    Directory of Open Access Journals (Sweden)

    Serpil Çokakoğlu

    2012-01-01

    Full Text Available

    Nowadays the importance given to facial aesthetic is increasing. The coincidence of facial, maxiller and mandibuler dental midlines is very important requiring facial aesthetic. Midline asymmetries can be seen in form of  dental, skeletal and/or soft tissue asymmetries. In most of cases midline asymmetries accompany with facial asymmetries. Even if the amount of patients with midline asymmetry is not known to be aware of their problems, dental midline deviations observing without facial deformity can be noticed by most of patients with the help of their orthodontists. Symmetry of the dental and facial midlines comes at the beginning of the factors affecting treatment planning. For this reason midlines and due to the multifactorial etiology of asymmetries all of the factors that cause asymmetry must be evaluated properly during treatment planning.

    In this present article, our aim is try to give answers following questions: “Which factors cause midline asymmetries?’’, “Which type of asymmetries can be seen commonly in clinical?’’, “Do the using mechanics affect occlusion?’’,“Is it necessary to correct each type of midline asymmetries?’’, “Is there any mean threshold for esthetically acceptable midline asymmetries?

    Keywords: Midline, asymmetry.

     

    ÖZET

    Günümüzde yüz estetiğine verilen önem giderek artmaktadır. Fasiyal, maksiller ve mandibular dental orta hatların uyumu yüz estetiğinin sağlanması açısından oldukça önemlidir. Orta hat asimetrileri dental, iskeletsel ve/veya yumuşak dokuyu ilgilendiren şekilde görülebilir. Birçok olguda fasiyal asimetri şeklinde karşımıza çıkar. Asimetrili hastaların probleminin farkında olup olmadığı bilinmese de, fasiyal deformitenin gözlenmediği dental orta hat sapmaları çoğu hasta tarafından ancak ortodontistin yönlendirmesiyle fark edilebilir. Dental ve

  5. Bethe vectors of quantum integrable models based on Uq( gl-hat N)

    International Nuclear Information System (INIS)

    We study quantum Uq( gl-hat N) integrable models solvable by the nested algebraic Bethe ansatz. Different formulas are given for the right and left universal off-shell nested Bethe vectors. It is shown that these formulas can be related by certain morphisms of the positive Borel subalgebra in Uq( gl-hat N) into analogous subalgebra in Uq−1( gl-hat N). (paper)

  6. Topological B-model and ${\\hat c}=1$ String Theory

    CERN Document Server

    Hyun, S; Park, J D; Yi, S H; Hyun, Seungjoon; Oh, Kyungho; Park, Jong-Dae; Yi, Sang-Heon

    2005-01-01

    We study the topological B-model on a deformed $\\Z_2$ orbifolded conifold by investigating variation of complex structures via quantum Kodaira-Spencer theories. The fermionic/brane formulation together with systematic utilization of symmetries of the geometry gives rise to a free fermion realization of the amplitudes. We derive Ward identities which solve the perturbed free energy exactly. We also obtain the corresponding Kontsevich-like matrix model. All these confirm the recent conjecture on the connection of the theory with ${\\hat c}=1$ type 0A string theory compactified at the radius $R=\\sqrt{\\alpha'/2}$.

  7. BLM realization for ${\\mathcal U}_{\\mathbb Z}(\\hat{\\frak{gl}}_n)$

    OpenAIRE

    Fu, Qiang

    2012-01-01

    In 1990, Beilinson-Lusztig-MacPherson (BLM) discovered a realization \\cite[5.7]{BLM} for quantum $\\frak{gl}_n$ via a geometric setting of quantum Schur algebras. We will generailze their result to the classical affine case. More precisely, we first use Ringel-Hall algebras to construct an integral form ${\\mathcal U}_{\\mathbb Z}(\\hat{\\frak{gl}}_n)$ of ${\\mathcal U}(\\hat{\\frak{gl}}_n)$, where ${\\mathcal U}(\\hat{\\frak{gl}}_n)$ is the universal enveloping algebra of the loop algebra $\\hat{\\frak{g...

  8. General survey of hAT transposon superfamily with highlight on hobo element in Drosophila.

    Science.gov (United States)

    Ladevèze, Véronique; Chaminade, Nicole; Lemeunier, Françoise; Periquet, Georges; Aulard, Sylvie

    2012-09-01

    The hAT transposons, very abundant in all kingdoms, have a common evolutionary origin probably predating the plant-fungi-animal divergence. In this paper we present their general characteristics. Members of this superfamily belong to Class II transposable elements. hAT elements share transposase, short terminal inverted repeats and eight base-pairs duplication of genomic target. We focus on hAT elements in Drosophila, especially hobo. Its distribution, dynamics and impact on genome restructuring in laboratory strains as well as in natural populations are reported. Finally, the evolutionary history of hAT elements, their domestication and use as transgenic tools are discussed.

  9. HST hot Jupiter Transmission Spectral Survey: A detection of Na and strong optical absorption in HAT-P-1b

    CERN Document Server

    Nikolov, N; Pont, F; Burrows, A S; Fortney, J J; Ballester, G E; Evans, T M; Huitson, C M; Wakeford, H R; Wilson, P A; Aigrain, S; Deming, D; Gibson, N P; Henry, G W; Knutson, H; Etangs, A Lecavelier des; Showman, A P; Vidal-Madjar, A; Zahnle, K

    2013-01-01

    We present an optical to near-infrared transmission spectrum of the hot Jupiter HAT-P-1b, based on HST observations, covering the spectral regime from 0.29 to 1.027{\\mu}m with STIS, which is coupled with a recent WFC3 transit (1.087 to 1.687{\\mu}m). We derive refined physical parameters of the HAT-P-1 system, including an improved orbital ephemeris. The transmission spectrum shows a strong absorption signature shortward of 0.55{\\mu}m, with a strong blueward slope into the near-ultraviolet. We detect atmospheric sodium absorption at a 3.3{\\sigma} significance level, but find no evidence for the potassium feature. The red data implies a marginally flat spectrum with a tentative absorption enhancement at wavelength longer than ~0.85{\\mu}m. The STIS and WFC3 spectra differ significantly in absolute radius level (4.3 +/- 1.6 pressure scale heights), implying strong optical absorption in the atmosphere of HAT-P-1b. The optical to near-infrared difference cannot be explained by stellar activity, as simulta- neous st...

  10. HATS-7b: A Hot Super Neptune Transiting a Quiet K Dwarf Star

    Science.gov (United States)

    Bakos, G. Á.; Penev, K.; Bayliss, D.; Hartman, J. D.; Zhou, G.; Brahm, R.; Mancini, L.; de Val-Borro, M.; Bhatti, W.; Jordán, A.; Rabus, M.; Espinoza, N.; Csubry, Z.; Howard, A. W.; Fulton, B. J.; Buchhave, L. A.; Ciceri, S.; Henning, T.; Schmidt, B.; Isaacson, H.; Noyes, R. W.; Marcy, G. W.; Suc, V.; Howe, A. R.; Burrows, A. S.; Lázár, J.; Papp, I.; Sári, P.

    2015-11-01

    We report the discovery by the HATSouth network of HATS-7b, a transiting Super-Neptune with a mass of 0.120 ± 0.012 {M}{{J}}, a radius of {0.563}-0.034+0.046 {R}{{J}}, and an orbital period of 3.1853 days. The host star is a moderately bright (V=13.340\\+/- 0.010 mag, {K}S=10.976\\+/- 0.026 mag) K dwarf star with a mass of 0.849 ± 0.027 {M}ȯ , a radius of {0.815}-0.035+0.049 {R}ȯ , and a metallicity of [{Fe}/{{H}}] =+0.250\\+/- 0.080. The star is photometrically quiet to within the precision of the HATSouth measurements, has low RV jitter, and shows no evidence for chromospheric activity in its spectrum. HATS-7b is the second smallest radius planet discovered by a wide-field ground-based transit survey, and one of only a handful of Neptune-size planets with mass and radius determined to 10% precision. Theoretical modeling of HATS-7b yields a hydrogen–helium fraction of 18 ± 4% (rock-iron core and H2–He envelope), or 9 ± 4% (ice core and H2–He envelope), i.e., it has a composition broadly similar to that of Uranus and Neptune, and very different from that of Saturn, which has 75% of its mass in H2–He. Based on a sample of transiting exoplanets with accurately (law relations for the envelopes of the mass–density distribution of exoplanets. HATS-7b, which, together with the recently discovered HATS-8b, is one of the first two transiting super-Neptunes discovered in the Southern sky, is a prime target for additional follow-up observations with Southern hemisphere facilities to characterize the atmospheres of Super-Neptunes (which we define as objects with mass greater than that of Neptune, and smaller than halfway between that of Neptune and Saturn, i.e., 0.054 {M}{{J}}\\lt {M}{{p}}\\lt 0.18 {M}{{J}}). The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia Universidad Católica de Chile (PUC). The station at

  11. Genetic reprogramming of human amniotic cells with episomal vectors: neural rosettes as sentinels in candidate selection for validation assays

    Directory of Open Access Journals (Sweden)

    Patricia G. Wilson

    2014-11-01

    Full Text Available The promise of genetic reprogramming has prompted initiatives to develop banks of induced pluripotent stem cells (iPSCs from diverse sources. Sentinel assays for pluripotency could maximize available resources for generating iPSCs. Neural rosettes represent a primitive neural tissue that is unique to differentiating PSCs and commonly used to identify derivative neural/stem progenitors. Here, neural rosettes were used as a sentinel assay for pluripotency in selection of candidates to advance to validation assays. Candidate iPSCs were generated from independent populations of amniotic cells with episomal vectors. Phase imaging of living back up cultures showed neural rosettes in 2 of the 5 candidate populations. Rosettes were immunopositive for the Sox1, Sox2, Pax6 and Pax7 transcription factors that govern neural development in the earliest stage of development and for the Isl1/2 and Otx2 transcription factors that are expressed in the dorsal and ventral domains, respectively, of the neural tube in vivo. Dissociation of rosettes produced cultures of differentiation competent neural/stem progenitors that generated immature neurons that were immunopositive for βIII-tubulin and glia that were immunopositive for GFAP. Subsequent validation assays of selected candidates showed induced expression of endogenous pluripotency genes, epigenetic modification of chromatin and formation of teratomas in immunodeficient mice that contained derivatives of the 3 embryonic germ layers. Validated lines were vector-free and maintained a normal karyotype for more than 60 passages. The credibility of rosette assembly as a sentinel assay for PSCs is supported by coordinate loss of nuclear-localized pluripotency factors Oct4 and Nanog in neural rosettes that emerge spontaneously in cultures of self-renewing validated lines. Taken together, these findings demonstrate value in neural rosettes as sentinels for pluripotency and selection of promising candidates for advance

  12. A Bayesian Atmospheric Retrieval Performed on HAT-P-16b and WASP-11b/HAT-P-10b

    Science.gov (United States)

    McIntyre, Kathleen J.; Harrington, Joseph; Challener, Ryan C.; Hardin, Matthew Ryan; Bowman, Oliver Oliver; Foster, Andrew S. D.; Lenius, Maria; Hartman, Joel D.; Bakos, Gaspar; Blecic, Jasmina; Cubillos, Patricio; Ariston Hardy, Ryan; Cameron, Andrew

    2016-10-01

    HAT-P-16b is a hot (equilibrium temperature 1626 ± 40 K, assuming zero Bond albedo and efficient energy redistribution), 4.19 ± 0.09 Jupiter-mass exoplanet orbiting an F8 star every 2.775960 ± 0.000003 days (Buchhave et al 2010). WASP-11b/HAT-P-10b is a cooler (1020 ± 17 K), 0.487 ± 0.018 Jupiter-mass exoplanet orbiting a K3 star every 3.7224747 ± 0.0000065 days (Bakos et al. 2009, co-discovered by West et al. 2008). We observed secondary eclipses of both planets using the 3.6 μm and 4.5 μm channels of the Spitzer Space Telescope's Infrared Array Camera (program ID 60003). We applied our Bayesian Atmospheric Radiative Transfer (BART) code to constrain the temperature-pressure profiles and atmospheric molecular abundances of the two planets. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

  13. Home Automated Telemanagement (HAT System to Facilitate Self-Care of Patients with Chronic Diseases

    Directory of Open Access Journals (Sweden)

    Joseph Finkelstein

    2003-06-01

    Full Text Available Successful patient self-management requires a multidisciplinary approach that includes regular patient assessment, disease-specific education, control of medication adherence, implementation of health behavior change models and social support. Existing systems for computer-assisted disease management do not provide this multidisciplinary patient support and do not address treatment compliance issues. We developed the Home Automated Telemanagement (HAT system for patients with different chronic health conditions to facilitate their self-care. The HAT system consists of a home unit, HAT server, and clinician units. Patients at home use a palmtop or a laptop connected with a disease monitor on a regular basis. Each HAT session consists of self-testing, feedback, and educational components. The self-reported symptom data and objective results obtained from disease-specific sensors are automatically sent from patient homes to the HAT server in the hospital. Any web-enabled device can serve as a clinician unit to review patient results. The HAT system monitors self-testing results and patient compliance. The HAT system has been implemented and tested in patients receiving anticoagulation therapy, patients with asthma, COPD and other health conditions. Evaluation results indicated high level of acceptance of the HAT system by the patients and that the system has a positive impact on main clinical outcomes and patient satisfaction with medical care.

  14. Midterm evaluation of hemodynamics of the Top Hat supraannular aortic valve

    DEFF Research Database (Denmark)

    Aagaard, Jan; Nissen, Henrik; Geha, Alexander S

    2010-01-01

    studies of Top Hat or CarboMedics intraannular valves. Echocardiography was performed 6-48 months after surgery with Top Hat sizes 21-27. Parameters evaluated included mean gradient, peak gradient, effective orifice area, and effective orifice area index. Preoperative and postoperative echocardiographic...

  15. Heroin-assisted treatment (HAT) a decade later : A brief update on science and politics

    NARCIS (Netherlands)

    Fischer, Benedikt; Oviedo-Joekes, Eugenia; Blanken, Peter; Haasen, Christian; Rehm, Juergen; Schechter, Martin T.; Strang, John; van den Brink, Wim

    2007-01-01

    Since the initial Swiss heroin-assisted treatment (HAT) study conducted in the mid-1990s, several other jurisdictions in Europe and North America have implemented HAT trials. All of these studies embrace the same goal-investigating the utility of medical heroin prescribing for problematic opioid use

  16. Giant Paperclip Necklaces, Soup-Can Rings and Cherry-Pie Hats

    Science.gov (United States)

    Winters, Laurel A.

    2011-01-01

    In this article, the author describes an art project inspired by the wearable sculpture art created by artist Marjorie Schick. Students used wallpaper paste and newspapers to create papier-mache for a mountain hat, a cherry-pie mask/hat, a "dress" shoe and a Cubistic mask. Cardboard was used in many of these things, in addition to being used as…

  17. Maximizing prosthetic valve size with the Top Hat supra-annular aortic valve

    DEFF Research Database (Denmark)

    Aagaard, Jan; Geha, Alexander S.

    2007-01-01

    BACKGROUND AND AIM OF THE STUDY: The CarboMedics Top Hat supra-annular aortic valve allows a one-size (and often two-size) increase over the standard intra-annular valve. This advantage should minimize the risk of patient-prosthesis mismatch, where the effective prosthetic valve orifice area...... is less than that of a normal valve. It is suggested that the ability to implant Top Hat valves having greater size, relative to standard intra-annular valves, may currently be under-utilized. Further, there has been some concern that Top Hat implantation can cause obstruction of the coronary ostia....... This study evaluates the authors' clinical experience with Top Hat supra-annular aortic valve size selection, and the technical aspects of implantation. METHODS: Between January 1999 and October 2005, a total of 251 consecutive patients underwent 252 aortic valve replacements with Top Hat supra...

  18. The man who mistook his wife for a hat

    CERN Document Server

    Sacks, Oliver

    2011-01-01

    Oliver Sacks’s The Man Who Mistook His Wife for a Hat tells the stories of individuals afflicted with fantastic perceptual and intellectual aberrations: patients who have lost their memories and with them the greater part of their pasts; who are no longer able to recognize people and common objects; who are stricken with violent tics and grimaces or who shout involuntary obscenities; whose limbs have become alien; who have been dismissed as retarded yet are gifted with uncanny artistic or mathematical talents. If inconceivably strange, these brilliant tales remain, in Dr. Sacks’s splendid and sympathetic telling, deeply human. They are studies of life struggling against incredible adversity, and they enable us to enter the world of the neurologically impaired, to imagine with our hearts what it must be to live and feel as they do. A great healer, Sacks never loses sight of medicine’s ultimate responsibility: “the suffering, afflicted, fighting human subject.”

  19. Supernova 1987 A - The nebular loops and 'Napoleon's Hat'

    Science.gov (United States)

    Wang, L.; Wampler, E. J.

    1992-08-01

    We discuss observations of the circumstellar environment of SN 1987A that were obtained between August 1989 and January 1992 at ESO's New Technology Telescope. We find that the angular dimensions of the two nebular loops (Wampler et al., 1990) have not changed during this period. Therefore these loops are confined to a small region. The expansion velocity of the loops is less than about 40 km/s if the loops expanded with a uniform velocity from a common origin. This structure and velocity is hard to reproduce with existing wind interaction models. Our observations further suggest that the Napoleon's Hat nebula does not originate from the general background LMC dust, but from a bow shock dust whose origins are closely related to the stellar winds from the progenitor star of SN 1987A.

  20. 30 CFR 77.1710-1 - Distinctively colored hard hats or hard caps; identification for newly employed, inexperienced...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Distinctively colored hard hats or hard caps... Distinctively colored hard hats or hard caps; identification for newly employed, inexperienced miners. Hard hats or hard caps distinctively different in color from those worn by experienced miners shall be worn...

  1. 30 CFR 75.1720-1 - Distinctively colored hard hats, or hard caps; identification for newly employed, inexperienced...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Distinctively colored hard hats, or hard caps... STANDARDS-UNDERGROUND COAL MINES Miscellaneous § 75.1720-1 Distinctively colored hard hats, or hard caps; identification for newly employed, inexperienced miners. Hard hats or hard caps distinctively different in...

  2. An old HAT in human p300/CBP and yeast Rtt109.

    Science.gov (United States)

    Bazan, J Fernando

    2008-06-15

    The crystal structure of the human p300 histone acetyltransferase (HAT) domain reveals a familiar alpha + beta fold with unique structural elaborations that merit its classification as a third divergent HAT branch alongside the GCN5-related N-acetyltransferase (GNAT) and MYST (MOZ, Ybf2/Sas3, Sas2, Tip60) families. Two key departures from the core GNAT/MYST HAT fold--a long unstructured chain (or "flap") overlaying the acetyl-CoA (AcCoA) binding groove, and a four-alpha-helix "tower" excursion from the main beta-sheet--critically contribute to the recognition and presumptive catalytic machinery of p300/CBP HAT enzymes. Kinetic and mutant analysis of this enlarged residue constellation in p300 (which is distinct from functional fingerprints drawn from GNAT or MYST complexes) led Liu et al., to suggest that p300/CBP works with an unorthodox "hit and run" mechanism that enlists Tyr1467 as the critical catalytic residue. In order to extend the evolutionary testbed for this variant HAT mechanism beyond the thin roll of p300/CBP orthologs, I propose that Rtt109, a novel yeast HAT that has so far eluded classification, is the prototype of a fungal clan of p300-related enzymes that preserve the embellished HAT fold, but further diversify its catalytic options. PMID:18583929

  3. Enhanced Generation of Integration-free iPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors.

    Science.gov (United States)

    Wen, Wei; Zhang, Jian-Ping; Xu, Jing; Su, Ruijun Jeanna; Neises, Amanda; Ji, Guang-Zhen; Yuan, Weiping; Cheng, Tao; Zhang, Xiao-Bing

    2016-06-14

    We previously reported the generation of integration-free induced pluripotent stem cells from adult peripheral blood (PB) with an improved episomal vector (EV) system, which uses the spleen focus-forming virus U3 promoter and an extra factor BCL-XL (B). Here we show an ∼100-fold increase in efficiency by optimizing the vector combination. The two most critical factors are: (1) equimolar expression of OCT4 (O) and SOX2 (S), by using a 2A linker; (2) a higher and gradual increase in the MYC (M) to KLF4 (K) ratio during the course of reprogramming, by using two individual vectors to express M and K instead of one. The combination of EV plasmids (OS + M + K + B) is comparable with Sendai virus in reprogramming efficiency but at a fraction of the cost. The generated iPSCs are indistinguishable from those from our previous approach in pluripotency and phenotype. This improvement lays the foundation for broad applications of episomal vectors in PB reprogramming.

  4. Enhanced Generation of Integration-free iPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors

    Directory of Open Access Journals (Sweden)

    Wei Wen

    2016-06-01

    Full Text Available We previously reported the generation of integration-free induced pluripotent stem cells from adult peripheral blood (PB with an improved episomal vector (EV system, which uses the spleen focus-forming virus U3 promoter and an extra factor BCL-XL (B. Here we show an ∼100-fold increase in efficiency by optimizing the vector combination. The two most critical factors are: (1 equimolar expression of OCT4 (O and SOX2 (S, by using a 2A linker; (2 a higher and gradual increase in the MYC (M to KLF4 (K ratio during the course of reprogramming, by using two individual vectors to express M and K instead of one. The combination of EV plasmids (OS + M + K + B is comparable with Sendai virus in reprogramming efficiency but at a fraction of the cost. The generated iPSCs are indistinguishable from those from our previous approach in pluripotency and phenotype. This improvement lays the foundation for broad applications of episomal vectors in PB reprogramming.

  5. HATS-11b AND HATS-12b: Two Transiting Hot Jupiters Orbiting Subsolar Metallicity Stars Selected for the K2 Campaign 7

    Science.gov (United States)

    Rabus, M.; Jordán, A.; Hartman, J. D.; Bakos, G. Á.; Espinoza, N.; Brahm, R.; Penev, K.; Ciceri, S.; Zhou, G.; Bayliss, D.; Mancini, L.; Bhatti, W.; de Val-Borro, M.; Csbury, Z.; Sato, B.; Tan, T.-G.; Henning, T.; Schmidt, B.; Bento, J.; Suc, V.; Noyes, R.; Lázár, J.; Papp, I.; Sári, P.

    2016-10-01

    We report the discovery of two transiting extrasolar planets from the HATSouth survey. HATS-11, a V = 14.1 G0-star shows a periodic 12.9 mmag dip in its light curve every 3.6192 days and a radial velocity variation consistent with a Keplerian orbit. HATS-11 has a mass of 1.000+/- 0.060 {M}⊙ , a radius of 1.444+/- 0.057 {R}⊙ and an effective temperature of 6060+/- 150 K, while its companion is a 0.85+/- 0.12 {M}{{J}}, 1.510+/- 0.078 {R}{{J}} planet in a circular orbit. HATS-12 shows a periodic 5.1 mmag flux decrease every 3.1428 days and Keplerian RV variations around a V = 12.8 F-star. HATS-12 has a mass of 1.489+/- 0.071 {M}⊙ , a radius of 2.21+/- 0.21 {R}⊙ , and an effective temperature of 6408+/- 75 K. For HATS-12b, our measurements indicate that this is a 2.38+/- 0.11 {M}{{J}}, 1.35+/- 0.17 {R}{{J}} planet in a circular orbit. Both host stars show subsolar metallicities of -0.390+/- 0.060 dex and -0.100+/- 0.040 dex, respectively, and are (slightly) evolved stars. In fact, HATS-11 is among the most metal-poor and, HATS-12, with a {log}{g}\\star of 3.923+/- 0.065, is among the most evolved stars hosting a hot-Jupiter planet. Importantly, HATS-11 and HATS-12 have been observed in long cadence by Kepler as part of K2 campaign 7 (EPIC216414930 and EPIC218131080 respectively). The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia Universidad Católica de Chile (PUC). The station at Las Campanas Observatory (LCO) of the Carnegie Institute is operated by PU in conjunction with PUC, the station at the High Energy Spectroscopic Survey (H.E.S.S.) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU. Based in part on data collected at the Subaru Telescope, which is operated by the National Astronomical Observatory of Japan. Based in part on

  6. HATS-11b and HATS-12b: Two transiting Hot Jupiters orbiting sub-solar metallicity stars selected for the K2 Campaign 7

    CERN Document Server

    Rabus, M; Hartman, J D; Bakos, G Á; Espinoza, N; Brahm, R; Penev, K; Ciceri, S; Zhou, G; Bayliss, D; Mancini, L; Bhatti, W; de Val-Borro, M; Csbury, Z; Sato, B; Tan, T -G; Henning, T; Schmidt, B; Bento, J; Suc, V; Noyes, R; Lázár, J; Papp, I; Sári, P

    2016-01-01

    We report the discovery of two transiting extrasolar planets from the HATSouth survey. HATS-11, a V=14.1 G0-star shows a periodic 12.9 mmag dip in its light curve every 3.6192 days and a radial velocity variation consistent with a Keplerian orbit. HATS-11 has a mass of 1.000 $\\pm$ 0.060 M$_{\\odot}$, a radius of 1.444 $\\pm$ 0.057 M$_{\\odot}$ and an effective temperature of 6060 $\\pm$ 150 K, while its companion is a 0.85 $\\pm$ 0.12 M$_J$, 1.510 $\\pm$ 0.078 R$_J$ planet in a circular orbit. HATS-12 shows a periodic 5.1 mmag flux decrease every 3.1428 days and Keplerian RV variations around a V=12.8 F-star. HATS-12 has a mass of 1.489 $\\pm$ 0.071 M$_{\\odot}$, a radius of 2.21 $\\pm$ 0.21 R$_{\\odot}$, and an effective temperature of 6408 $\\pm$ 75 K. For HATS-12, our measurements indicate that this is a 2.38 $\\pm$ 0.11 M$_J$, 1.35 $\\pm$ 0.17 R$_J$ planet in a circular orbit. Both host stars show sub-solar metallicity of -0.390 $\\pm$ 0.060 dex and -0.100 $\\pm$ 0.040 dex, respectively and are (slightly) evolved stars....

  7. Lattice measurement of the couplings $\\hat g_\\infty$ and $g_{B^\\ast B \\pi}$

    CERN Document Server

    Abada, A; Boucaud, P; Herdoiza, G; Leroy, J P; Le Yaouanc, A; Pène, O; Boucaud, Ph.

    2004-01-01

    We present the results of a quenched lattice QCD study of the coupling $\\hat g$, in the static heavy quark limit. After combining this with our previous results obtained by using propagating heavy quarks with a mass around the physical charm quark, we are able to interpolate to the $b$-quark sector. Our results are $\\hat g_\\infty = 0.48 \\pm 0.03\\pm 0.11$, $\\hat g_b = 0.58 \\pm 0.06 \\pm 0.10$, and $\\g_{B^\\ast B \\pi} = 47 \\pm 5 \\pm 8$.

  8. Parameters of Recent Transits of HAT-P-23b

    CERN Document Server

    Ramón-Fox, Felipe G

    2012-01-01

    Four transits of the exoplanet HAT-P-23b were recently observed with the 0.36m telescope at the Universidad de Monterrey Observatory. The four light curves were successfully combined to obtain a resulting one with reduced scattering per bin. This one was modeled using a Monte Carlo method to obtain the essential parameters that characterize the system. Assuming orbital parameters such as eccentricity, e, and longitude of periastron, w, from the discovery paper, we found values of Rp/R* = 0.1105 +0.0015-0.0013 for the planet-to-star radius ratio, a/R* = 4.23 +0.06-0.12 for the scaled semimajor axis, and an orbital inclination of the system of i = 87.9d +1.5-2.2. We also derive an improved orbital period of 1.2128868 +- 0.0000004 days (To = 2,454,852.26542 +- 0.00018 BJD_TDB) for the system.

  9. Application of Human-Autonomy Teaming (HAT) Patterns to Reduce Crew Operations (RCO)

    Science.gov (United States)

    Shively, R. Jay; Brandt, Summer L.; Lachter, Joel; Matessa, Mike; Sadler, Garrett; Battiste, Henri

    2016-01-01

    Unmanned aerial systems, robotics, advanced cockpits, and air traffic management are all examples of domains that are seeing dramatic increases in automation. While automation may take on some tasks previously performed by humans, humans will still be required, for the foreseeable future, to remain in the system. The collaboration with humans and these increasingly autonomous systems will begin to resemble cooperation between teammates, rather than simple task allocation. It is critical to understand this human-autonomy teaming (HAT) to optimize these systems in the future. One methodology to understand HAT is by identifying recurring patterns of HAT that have similar characteristics and solutions. This paper applies a methodology for identifying HAT patterns to an advanced cockpit project.

  10. No isomorphism between the affine $\\hat sl(2)$ algebra and the N=2 superconformal algebras

    CERN Document Server

    Gato-Rivera, Beatriz

    2008-01-01

    Since 1999 it became obvious that the would be `isomorphism' between the affine $\\hat sl(2)$ algebra and the N=2 superconformal algebras, proposed by some authors, simply does not work. However, this issue was never properly discussed in the literature and, as a result, some confusion still remains. In this article we finally settle down, clearly and unambiguously, the true facts: there is no isomorphism between the affine $\\hat sl(2)$ algebra and the N=2 superconformal algebras.

  11. HATS-17b: A Transiting Compact Warm Jupiter in a 16.3 Days Circular Orbit

    CERN Document Server

    Brahm, R; Bakos, G Á; Penev, K; Espinoza, N; Rabus, M; Hartman, J D; Bayliss, D; Ciceri, S; Zhou, G; Mancini, L; Tan, T G; de Val-Borro, M; Bhatti, W; Csubry, Z; Bento, J; Henning, T; Schmidt, B; Suc, V; Lázár, J; Papp, I; Sári, P

    2015-01-01

    We report the discovery of HATS-17b, the first transiting warm Jupiter of the HATSouth network. HATS-17b transits its bright (V=12.4) G-type (M$_{\\star}$=1.131 $\\pm$ 0.030 M$_{\\odot}$, R$_{\\star}$=1.091$^{+0.070}_{-0.046}$ R$_{\\star}$) metal-rich ([Fe/H]=+0.3 dex) host star in a circular orbit with a period of P=16.2546 days. HATS-17b has a very compact radius of 0.777 $\\pm$ 0.056 R$_J$ given its Jupiter-like mass of 1.338 $\\pm$ 0.065 M$_J$. Up to 50% of the mass of HATS-17b may be composed of heavy elements in order to explain its high density with current models of planetary structure. HATS-17b is the longest period transiting planet discovered to date by a ground-based photometric survey, and is one of the brightest transiting warm Jupiter systems known. The brightness of HATS-17b will allow detailed follow-up observations to characterize the orbital geometry of the system and the atmosphere of the planet.

  12. Phase II, Title I engineering assessment of inactive uranium mill tailings, Mexican Hat site, Mexican Hat, Utah

    International Nuclear Information System (INIS)

    An engineering assessment of the problems resulting from the existence of radioactive uranium mill tailings at the Mexican Hat millsite in Utah is presented. Topographic maps, data on core drillings and radiometric measurements sufficient to determine areas and volumes of tailings and other radium-contaminated materials, the evaluation of resulting radiation exposures of individuals residing nearby, the investigation of site hydrology and meteorology, and the evaluation and costing of alternative corrective actions are presented. Radon gas release from the 2,200,000 tons of tailings on the site constitutes the most significant environmental impact. T he six alternative actions presented are directed towards restricting access to the site, returning the windblown tailings to the piles and stabilizing the piles with cover material, and consolidating the two piles into one pile and stabilizing it with cover material. Fencing around the site or the tailings and the decontamination of mill buildings is included in all options. Costs of the options range from $370,000 to $4,390,000

  13. Remedial Action Plan for the codisposal and stabilization of the Monument Valley and Mexican Hat uranium mill tailings at Mexican Hat, Utah: Appendices C--E. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-02-01

    This document provides appendices C, D, and E this Remedial Action Plan (RAP) which is a revision of the original Mexican Hat Remedial Action Plan and RAP Modification submitted in July 1988 and January 1989, respectively, along with updated design documents. Appendix C provide the Radiological Support Plan, Appendix D provides the Site Characterization, and Appendix E provides the Water Resources Protection Strategy.

  14. Integration of Bioorthogonal Probes and Q-FRET for the Detection of Histone Acetyltransferase Activity.

    Science.gov (United States)

    Han, Zhen; Luan, Yepeng; Zheng, Yujun George

    2015-12-01

    Histone acetyltransferases (HATs) are key players in the epigenetic regulation of gene function. The recent discovery of diverse HAT substrates implies a broad spectrum of cellular functions of HATs. Many pathological processes are also intimately associated with the dysregulation of HAT levels and activities. However, detecting the enzymatic activity of HATs has been challenging, and this has significantly impeded drug discovery. To advance the field, we developed a convenient one-pot, mix-and-read strategy that is capable of directly detecting the acylated histone product through a fluorescent readout. The strategy integrates three technological platforms-bioorthogonal HAT substrate labeling, alkyne-azide click chemistry, and quenching FRET-into one system for effective probing of HAT enzyme activity. PMID:26455821

  15. A marketingeszközök és –tevékenységek részvényesi értékre gyakorolt hatása (The effect of marketing assets and activities on shareholder value)

    OpenAIRE

    Kovács, Kármen; Kuti, Mónika

    2012-01-01

    A vállalati marketing pénzügyi teljesítményre, különösen részvényesi értékre gyakorolt hatásának kimutatása mind fontosabbá válik a marketingráfordítások nagyságának növekedésével, valamint annak felismerésével, hogy a részvényesek számára vevői érték nélkül nem lehet hosszú távon értéket biztosítani, azonban kedvező piaci eredményekkel sem feltétlenül valósul meg a pénzügyi teljesítmény növekedése. A szerzők tanulmányukban a marketingeszközök és -tevékenységek részvényesi értékre...

  16. Top Hat HELLISH (Hot electron light emitting and lasing in heterostructures)

    CERN Document Server

    Wah, J Y

    2003-01-01

    Hot electron light emitting and lasing in semiconductor heterostructures (HELLISH) is a longitudinal transport structure comprising of a GaAs Quantum Well within an Al sub x Ga sub 1 sub - sub x As pn junction. The light emission from the HELLISH device was previously believed to be merely due to hot electron effects. In the current work, we showed, however, that the device can be operated even at low applied electric fields where the hot electron effects are essentially negligible. Thus, a novel model for operation with the new concept of 'quasi-flatband condition' is introduced. In order to investigate new functionalities of the HELLISH devices, a new structure with longer p-channel, nicknamed Top Hat HELLISH (THH), is also fabricated and demonstrated. In terms of the energy band profile, the HELLISH device has a monotonic build-in potential barrier along the heterojunction. The operation is through tilting the bands and hence allowing carrier diffusion into the active region under the quasi-flatband condit...

  17. Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing.

    Science.gov (United States)

    Tong, Kevin; Keller, Thomas; Hoffman, Charles S; Annunziato, Anthony T

    2012-09-01

    The Hat1 histone acetyltransferase has been implicated in the acetylation of histone H4 during chromatin assembly. In this study, we have characterized the Hat1 complex from the fission yeast Schizosaccharomyces pombe and have examined its role in telomeric silencing. Hat1 is found associated with the RbAp46 homologue Mis16, an essential protein. The Hat1 complex acetylates lysines 5 and 12 of histone H4, the sites that are acetylated in newly synthesized H4 in a wide range of eukaryotes. Deletion of hat1 in S. pombe is itself sufficient to cause the loss of silencing at telomeres. This is in contrast to results obtained with an S. cerevisiae hat1Δ strain, which must also carry mutations of specific acetylatable lysines in the H3 tail domain for loss of telomeric silencing to occur. Notably, deletion of hat1 from S. pombe resulted in an increase of acetylation of histone H4 in subtelomeric chromatin, concomitant with derepression of this region. A similar loss of telomeric silencing was also observed after growing cells in the presence of the deacetylase inhibitor trichostatin A. However, deleting hat1 did not cause loss of silencing at centromeres or the silent mating type locus. These results point to a direct link between Hat1, H4 acetylation, and the establishment of repressed telomeric chromatin in fission yeast. PMID:22771823

  18. Schizosaccharomyces pombe Hat1 (Kat1) Is Associated with Mis16 and Is Required for Telomeric Silencing

    OpenAIRE

    Tong, Kevin; Keller, Thomas; Hoffman, Charles S.; Anthony T. Annunziato

    2012-01-01

    The Hat1 histone acetyltransferase has been implicated in the acetylation of histone H4 during chromatin assembly. In this study, we have characterized the Hat1 complex from the fission yeast Schizosaccharomyces pombe and have examined its role in telomeric silencing. Hat1 is found associated with the RbAp46 homologue Mis16, an essential protein. The Hat1 complex acetylates lysines 5 and 12 of histone H4, the sites that are acetylated in newly synthesized H4 in a wide range of eukaryotes. Del...

  19. HATS-5b: A Transiting hot-Saturn from the HATSouth Survey

    CERN Document Server

    Zhou, G; Penev, K; Bakos, G Á; Hartman, J D; Jordán, A; Mancini, L; Mohler, M; Csubry, Z; Ciceri, S; Brahm, R; Rabus, M; Buchhave, L; Henning, T; Suc, V; Espinoza, N; Béky, B; Noyes, R W; Schmidt, B; Butler, R P; Shectman, S; Thompson, I; Crane, J; Sato, B; Csák, B; Lázár, J; Papp, I; Sári, P; Nikolov, N

    2014-01-01

    We report the discovery of HATS-5b, a transiting hot-Saturn orbiting a G type star, by the HAT-South survey. HATS-5b has a mass of Mp=0.24 Mj, radius of Rp=0.91 Rj, and transits its host star with a period of P=4.7634d. The radius of HATS-5b is consistent with both theoretical and empirical models. The host star has a V band magnitude of 12.6, mass of 0.94 Msun, and radius of 0.87 Rsun. The relatively high scale height of HATS-5b, and the bright, photometrically quiet host star, make this planet a favourable target for future transmission spectroscopy follow-up observations. We reexamine the correlations in radius, equilibrium temperature, and metallicity of the close-in gas-giants, and find hot Jupiter-mass planets to exhibit the strongest dependence between radius and equilibrium temperature. We find no significant dependence in radius and metallicity for the close-in gas-giant population.

  20. HATS-8b: A Low-Density Transiting Super-Neptune

    CERN Document Server

    Bayliss, D; Bakos, G Á; Penev, K; Zhou, G; Brahm, R; Rabus, M; Jordán, A; Mancini, L; de Val-Borro, M; Bhatti, W; Espinoza, N; Csubry, Z; Howard, A W; Fulton, B J; Buchhave, L A; Henning, T; Schmidt, B; Ciceri, S; Noyes, R W; Isaacson, H; Marcy, G W; Suc, V; Lázár, J; Papp, I; Sári, P

    2015-01-01

    HATS-8b is a low density transiting super-Neptune discovered as part of the HATSouth project. The planet orbits its solar-like G dwarf host (V=14.03 $\\pm$ 0.10 and T$_{eff}$ =5679 $\\pm$ 50 K) with a period of 3.5839 d. HATS-8b is the third lowest mass transiting exoplanet to be discovered from a wide-field ground based search, and with a mass of 0.138 $\\pm$ 0.019 M$_J$ it is approximately half-way between the masses of Neptune and Saturn. However HATS-8b has a radius of 0.873 (+0.123,-0.075) R$_J$, resulting in a bulk density of just 0.259 $\\pm$ 0.091 g.cm$^{-3}$. The metallicity of the host star is super-Solar ([Fe/H]=0.210 $\\pm$ 0.080), arguing against the idea that low density exoplanets form from metal-poor environments. The low density and large radius of HATS-8b results in an atmospheric scale height of almost 1000 km, and in addition to this there is an excellent reference star of near equal magnitude at just 19 arcsecond separation on the sky. These factors make HATS-8b an exciting target for future a...

  1. Dynamical Constraints on the Core Mass of Hot Jupiter HAT-P-13b

    CERN Document Server

    Buhler, Peter; Batygin, Konstantin; Fulton, BJ; Fortney, Jonathan; Burrows, Adam; Wong, Ian

    2016-01-01

    HAT-P-13b is a Jupiter-mass transiting exoplanet that has settled onto a stable, short-period, and mildly eccentric orbit as a consequence of the action of tidal dissipation and perturbations from a second, highly eccentric, outer companion. Due to the special orbital configuration of the HAT-P-13 system, the magnitude of HAT-P-13b's eccentricity ($e_b$) is in part dictated by its Love number ($k_{2_b}$), which is in turn a proxy for the degree of central mass concentration in its interior. Thus, the measurement of $e_b$ constrains $k_{2_b}$ and allows us to place otherwise elusive constraints on the mass of HAT-P-13b's core ($M_{\\rm{core,b}}$). In this study we derive new constraints on the value of $e_b$ by observing two secondary eclipses of HAT-P-13b with the Infrared Array Camera on board the $\\textit{Spitzer Space Telescope}$. We fit the measured secondary eclipse times simultaneously with radial velocity measurements and find that $e_b = 0.00700 \\pm 0.00100$. We then use octupole-order secular perturba...

  2. HATS-1b: The First Transiting Planet Discovered by the HATSouth Survey

    CERN Document Server

    Penev, K; Bayliss, D; Jordán, A; Mohler, M; Zhou, G; Suc, V; Rabus, M; Hartman, J D; Mancini, L; Béky, B; Csubry, Z; Buchhave, L; Henning, T; Nikolov, N; Csák, B; Brahm, R; Espinoza, N; Conroy, P; Noyes, R W; Sasselov, D D; Schmidt, B; Wright, D J; Tinney, C G; Addison, B C; Lázár, J; Papp, I; Sári, P

    2012-01-01

    We report the discovery of HATS-1b, a transiting extrasolar planet orbiting the moderately bright V=12.05 G dwarf star GSC 6652-00186, and the first planet discovered by HATSouth, a global network of autonomous wide-field telescopes. HATS-1b has a period P~3.4465 d, mass Mp~1.86MJ, and radius Rp~1.30RJ. The host star has a mass of 0.99Msun, and radius of 1.04Rsun. The discovery light curve of HATS-1b has near continuous coverage over several multi-day periods, demonstrating the power of using a global network of telescopes to discover transiting planets.

  3. [Usefulness of top-hat transform processing in whole body bone scintigraphy].

    Science.gov (United States)

    Kita, Akinobu; Sugimoto, Katsuya; Tsuchida, Tatsurou; Kishimoto, Takahiro; Toi, Akiko; Shimada, Masato; Adachi, Toshiki

    2013-01-01

    To assess the usefulness of top-hat transform processing in whole body bone scintigraphy, five radiological technicians interpreted both original and top-hat processed images to determine the improvement of lesion detectability and interpretation time. For the evaluation of detectability, receiver operating characteristic (ROC) analysis was performed. The area under the curve (AUC) calculated from the ROC curve was improved in all observers (from 0.786 to 0.864 in average), although no significant difference was observed. However, the interpretation time was improved significantly (from 24.5 to 16.2 s in average). Top-hat transform processing in whole body bone scintigraphy is thought to be useful for the improvement of lesion detectability and interpretation time.

  4. Gauge invariant definition of the jet quenching parameter $\\hat{q}$

    CERN Document Server

    Benzke, Michael

    2012-01-01

    We use the framework of Glauber extended Soft-Collinear Effective Theory to explicitly derive a gauge invariant expression of the jet quenching parameter $\\hat{q}$. The effective theory approach offers a systematic power counting scheme at the Lagrangian level and allows for a consistent treatment of the relevant scales in the problem. Employing this approach in a covariant gauge scenario lead to an expression for $\\hat{q}$ containing the expectation value of two light-cone Wilson lines. We find that in a general gauge, additional interaction terms in the Lagrangian have to be considered, leading to the introduction of transverse gauge links.

  5. The effect of hat on phototherapy-induced hypocalcemia in jaundiced full-term neonates

    Directory of Open Access Journals (Sweden)

    Ezzeldin Z

    2015-08-01

    Full Text Available Zahraa Ezzeldin, Yasmeen Mansi, Tamer A Abdelhamid, Mohamed Sabry Department of Pediatrics, Faculty of Medicine, Cairo University, Giza, Egypt Background: It has been hypothesized that phototherapy leads to increased calcium absorption by the bones through irradiating the pineal gland and reducing melatonin level. There is some evidence that the use of a stockinet cap to cover the head prevents phototherapy-induced hypocalcemia. Study design: This was a randomized controlled trial, including 124 full-term neonates, weighing >2,500 g, in the first 7 days of life, who developed a bilirubin level ranging from 15 to 20 mg/dL and needed treatment with phototherapy. Our neonates were divided into two groups: Group A without the hat, and Group B with the hat. We designed a dark-colored hat that covered the entire head, including the occipital area, ears, and neck, to prevent passage of light. The hat was used from the time of admission and for the 48 hours of treatment with phototherapy. Ca levels were measured on admission and after 48 hours of phototherapy. The variables were compared using Student’s t-test, chi-square test, and the repeated-measures test. Results: There was no difference in the mean Ca levels in the two groups on admission. However, after 48 hours of phototherapy, there was a trend toward an increased Ca level in the group with the hat; 8.74±0.95 mg/dL vs 8.51±0.24 mg/dL in the control group. Moreover, there was a statistically significant decrease in the incidence of neonates with hypocalcemia in Group B (with hat in only six cases (9.7%, compared to 15 cases (24.2% in Group A (without hat; P=0.031. Conclusion: Phototherapy-induced hypocalcemia can be prevented by covering the head during phototherapy. This seems to be a safe, effective, and cheap method to prevent hypocalcemia and its complications, with no need for prophylactic administration of calcium. Keywords: neonatal jaundice, phototherapy-induced hypocalcemia, hat

  6. Red Hat Enterprise Virtualization - KVM-based infrastructure services at BNL

    Energy Technology Data Exchange (ETDEWEB)

    Cortijo, D.

    2011-06-14

    Over the past 18 months, BNL has moved a large percentage of its Linux-based servers and services into a Red Hat Enterprise Virtualization (RHEV) environment. This presentation will address our approach to virtualization, critical decision points, and a discussion of our implementation. Specific topics will include an overview of hardware and software requirements, networking, and storage; discussion of the decision of Red Hat solution over competing products (VMWare, Xen, etc); details on some of the features of RHEV - both current and on their roadmap; Review of performance and reliability gains since deployment completion; path forward for RHEV at BNL and caveats and potential problems.

  7. Characterization of the atmosphere of the hot Jupiter HAT-P-32Ab and the M-dwarf companion HAT-P-32B

    CERN Document Server

    Zhao, Ming; Wright, Jason T; Knutson, Heather A; Burrows, Adam; Fortney, Johnathan; Ngo, Henry; Fulton, Benjamin J; Baranec, Christoph; Riddle, Reed; Law, Nicholas M; Muirhead, Philip S; Hinkley, Sasha; Showman, Adam P; Curtis, Jason; Burruss, Rick

    2014-01-01

    We report secondary eclipse photometry of the hot Jupiter HAT-P-32Ab, taken with Hale/WIRC in H and Ks bands and with Spitzer/IRAC at 3.6 and 4.5 micron. We carried out adaptive optics imaging of the planet host star HAT-P-32A and its companion HAT-P-32B in the near-IR and the visible. We clearly resolve the two stars from each other and find a separation of 2.923" +/- 0. 004" and a position angle 110.64 deg +/- 0.12 deg. We measure the flux ratios of the binary in g' r' i' z' and H & Ks bands, and determine Teff = 3565 +/- 82 K for the companion star, corresponding to an M1.5 dwarf. We use PHOENIX stellar atmosphere models to correct the dilution of the secondary eclipse depths of the hot Jupiter due to the presence of the M1.5 companion. We also improve the secondary eclipse photometry by accounting for the non-classical, flux-dependent nonlinearity of the WIRC IR detector in the H band. We measure planet-to-star flux ratios of 0.090 +/- 0.033%, 0.178 +/- 0.057%, 0.364 +/- 0.016%, and 0.438 +/- 0.020% i...

  8. WASP-35b, WASP-48b, AND HAT-P-30b/WASP-51b: TWO NEW PLANETS AND AN INDEPENDENT DISCOVERY OF A HAT PLANET

    International Nuclear Information System (INIS)

    We report the detection of WASP-35b, a planet transiting a metal-poor ([Fe/H] = -0.15) star in the Southern hemisphere, WASP-48b, an inflated planet which may have spun-up its slightly evolved host star of 1.75 Rsun in the Northern hemisphere, and the independent discovery of HAT-P-30b/WASP-51b, a new planet in the Northern hemisphere. Using WASP, RISE, Faulkes Telescope South, and TRAPPIST photometry, with CORALIE, SOPHIE, and NOT spectroscopy, we determine that WASP-35b has a mass of 0.72 ± 0.06 MJ and radius of 1.32 ± 0.05RJ , and orbits with a period of 3.16 days, WASP-48b has a mass of 0.98 ± 0.09 MJ , radius of 1.67 ± 0.10 RJ , and orbits in 2.14 days, while HAT-P-30b/WASP-51b, with an orbital period of 2.81 days, is found to have a mass of 0.76 ± 0.05 MJ and radius of 1.42 ± 0.03 RJ , agreeing with values of 0.71 ± 0.03 MJ and 1.34 ± 0.07 RJ reported for HAT-P-30b.

  9. Isolation and characterization of Vibrio cholerae isolates from seafood in Hat Yai City, Songkhla, Thailand.

    Science.gov (United States)

    Preeprem, Sutima; Mittraparp-arthorn, Pimonsri; Bhoopong, Phuangthip; Vuddhakul, Varaporn

    2014-11-01

    Seafood has been identified as an important source of Vibrio cholerae in Thailand, especially in the Southern coastal region. In this study, we isolated and characterized V. cholerae from seafood obtained from several markets in Hat Yai city, Southern Thailand. A total of 100 V. cholerae isolates were obtained from 55 of 125 seafood samples. The dominant serotype was non-O1/non-O139. Polymerase chain reaction (PCR) analysis was used to detect the presence of pathogenesis-related genes. The stn/sto and hlyA El Tor virulence genes were detected in 20% and 96% of the isolates, respectively. None of the isolates were positive for the ctxA, tcpA, zot, and ace genes. Only 6% of the isolates carried the T3SS gene (vcsV2); however, the majority of the isolates (96%) carried the T6SS gene (vasH). Representative isolates (n=35) that exhibited various virulence gene patterns were randomly selected and analyzed for their hemolytic activity, antibiotic susceptibility, biofilm formation, and genotype. Hemolytic activity using sheep red blood cells was detected in only one of the hlyA-negative isolates. Apart from ampicillin, all isolates were pansusceptible to five test antibiotics. Biofilm production was observed in most of the isolates, and there was no difference in the presence of a biofilm between the smooth and rugose isolates. Using the enterobacterial repetitive intergenic consensus-PCR method, clonal relationships were observed among the isolates that exhibited identical virulence gene patterns.

  10. WASP-40b: independent discovery of the 0.6-Mjup transiting exoplanet HAT-P-27b

    CERN Document Server

    Anderson, D R; Boisse, I; Bouchy, F; Collier-Cameron, A; Faedi, F; Hebrard, G; Hellier, C; Lendl, M; Moutou, C; Pollacco, D; Santerne, A; Smalley, B; Smith, A M S; Todd, I; Triaud, A H M J; West, R G; Wheatley, P J; Bento, J; Enoch, B; Gillon, M; Maxted, P F L; McCormac, J; Queloz, D; Simpson, E K; Skillen, I

    2011-01-01

    From WASP photometry and SOPHIE radial velocities we report the discovery of WASP-40b (= HAT-P-27b), a 0.6-Mjup planet that transits its 12th magnitude host star every 3.04 d. The host star is of late-G or early-K type and likely has an above-Solar metallicity, with [Fe/H] = 0.14 +/- 0.11. The planet's mass and radius are typical of the known hot Jupiters, thus adding another system to the apparent pileup of transiting planets with periods near 3 to 4 d. Our parameters match those of the recent HATnet announcement of the same planet, thus giving confidence in the techniques used. We report a possible indication of stellar activity in the host star.

  11. Boundary state of $U_q(\\hat{gl}(N|N))$ analog of half-infinite $t-J$ model

    CERN Document Server

    Kojima, Takeo

    2015-01-01

    The $U_q(\\hat{gl}(N|N))$-analog of the half-infinite $t-J$ model with a boundary is considered by using the vertex operator approach. We find explicit bosonic formula of the boundary state in the integrable highest-weight module over the quantum superalgebra $U_q(\\hat{gl}(N|N))$.

  12. Warm Spitzer and Palomar near-IR secondary eclipse photometry of two hot Jupiters: WASP-48b and HAT-P-23b

    Energy Technology Data Exchange (ETDEWEB)

    O' Rourke, Joseph G.; Knutson, Heather A.; Désert, Jean-Michel [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States); Zhao, Ming [Department of Astronomy and Astrophysics, 525 Davey Laboratory, The Pennsylvania State University, University Park, PA 16802 (United States); Fortney, Jonathan J. [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Burrows, Adam [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 05844 (United States); Agol, Eric [Department of Astronomy, University of Washington, Box 351580, Seattle, WA 98195 (United States); Deming, Drake [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States); Howard, Andrew W. [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); Lewis, Nikole K. [Department of Earth, Atmospheric, and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Showman, Adam P. [Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 85721 (United States); Todorov, Kamen O. [Institute for Astronomy, ETH Zürich, Wolfgang-Pauli-Strasse 27, 8093 Zürich (Switzerland)

    2014-02-01

    We report secondary eclipse photometry of two hot Jupiters, WASP-48b and HAT-P-23b, at 3.6 and 4.5 μm taken with the InfraRed Array Camera aboard the Spitzer Space Telescope during the warm Spitzer mission and in the H and K{sub S} bands with the Wide Field IR Camera at the Palomar 200 inch Hale Telescope. WASP-48b and HAT-P-23b are Jupiter-mass and twice Jupiter-mass objects orbiting an old, slightly evolved F star and an early G dwarf star, respectively. In the H, K{sub S} , 3.6 μm, and 4.5 μm bands, respectively, we measure secondary eclipse depths of 0.047% ± 0.016%, 0.109% ± 0.027%, 0.176% ± 0.013%, and 0.214% ± 0.020% for WASP-48b. In the K{sub S} , 3.6 μm, and 4.5 μm bands, respectively, we measure secondary eclipse depths of 0.234% ± 0.046%, 0.248% ± 0.019%, and 0.309% ± 0.026% for HAT-P-23b. For WASP-48b and HAT-P-23b, respectively, we measure delays of 2.6 ± 3.9 minutes and 4.0 ± 2.4 minutes relative to the predicted times of secondary eclipse for circular orbits, placing 2σ upper limits on |ecos ω| of 0.0053 and 0.0080, both of which are consistent with circular orbits. The dayside emission spectra of these planets are well-described by blackbodies with effective temperatures of 2158 ± 100 K (WASP-48b) and 2154 ± 90 K (HAT-P-23b), corresponding to moderate recirculation in the zero albedo case. Our measured eclipse depths are also consistent with one-dimensional radiative transfer models featuring varying degrees of recirculation and weak thermal inversions or no inversions at all. We discuss how the absence of strong temperature inversions on these planets may be related to the activity levels and metallicities of their host stars.

  13. Towards top-hat spatial shaping of ultrafast laser beam based on Zernike polynomials

    Science.gov (United States)

    Mauclair, Cyril; Faure, Nicolas; Houzet, Julien

    2016-04-01

    Femtosecond laser micro machining of surfaces knows a gain of interest as it demonstrates efficient and precise processing with reduced side effects around the irradiated zone, and also because of the remarkable costs reduction and reliability improvements of nowadays commercially available sources. Controlling the intensity distribution spatially can offer a supplementary degree of flexibility and precision in achieving user-defined ablation spatial profile, drilling, cutting of materials or in-volume laser-induced modifications. In this scope, the possibility to generate a top-hat intensity distribution by spatially shaping the beam wavefront is studied in this work. An optimization of Zernike polynomials coefficients is conducted to numerically determine an adequate phase mask that shapes the laser intensity distribution following a targeted top hat distribution in the processing plane, usually at the focal length of a converging lens. The efficiency of the method is numerically investigated in the optimization by evaluation of the root mean square error (RMS) between the top-hat target and the calculated laser distribution in the far field. We numerically verify that acceptable top-hat beam shaping of various size can be achieved with a sufficient number of Zernike polynomials, opening the way to phase mask calculations adapted to the wavefront modulator ability to reproduce Zernike polynomials.

  14. Morphological hat-transform scale spaces and their use in texture classification

    NARCIS (Netherlands)

    Jalba, A.C.; Roerdink, J.B.T.M.; Wilkinson, M.H.F.

    2003-01-01

    In this paper we present a multi-scale morphological method for use in texture classification. A connected operator similar to the morphological hat-transform is defined, and two scale-space representations are built. The most important features are extracted from the scale spaces by unsupervised cl

  15. The Mexican hat effect on the delamination buckling of a compressed thin film

    Science.gov (United States)

    Zhang, Yin; Liu, Yun

    2014-12-01

    Because of the interaction between film and substrate, the film buckling stress can vary significantly, depending on the delamination geometry, the film and substrate mechanical properties. The Mexican hat effect indicates such interaction. An analytical method is presented, and related dimensional analysis shows that a single dimensionless parameter can effectively evaluate the effect.

  16. WASP-12b and HAT-P-8b are Members of Triple Star Systems

    CERN Document Server

    Bechter, Eric B; Ngo, Henry; Knutson, Heather A; Batygin, Konstantin; Hinkley, Sasha; Muirhead, Phillip S; Johnson, John Asher; Howard, Andrew W; Montet, Benjamin T; Matthews, Christopher T; Morton, Timothy D

    2013-01-01

    We present high spatial resolution images that demonstrate the hot Jupiters WASP-12b and HAT-P-8b orbit the primary star of hierarchical triple star systems. In each case, two distant companions with colors and brightness consistent with M dwarfs co-orbit the planet host as well as one another. Our adaptive optics images spatially resolve the secondary around WASP-12, previously identified by Bergfors et al. 2011 and Crossfield et al. 2012, into two distinct sources separated by 84.3+/-0.6 mas (21 +/- 3 AU). We find that the secondary to HAT-P-8, also identified by Bergfors et al. 2011, is in fact composed of two stars separated by 65.3+/-0.5 mas (15+/-1 AU). Our follow-up observations demonstrate physical association through common proper-motion. HAT-P-8 C has a particularly low mass, which we estimate to be 0.18+/-0.02Msun using photometry. Due to their hierarchy, WASP-12 BC and HAT-P-8 BC will enable the first dynamical mass determination for hot Jupiter stellar companions. These previously well-studied pl...

  17. HATS-5b: A TRANSITING HOT SATURN FROM THE HATSouth SURVEY

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, G.; Bayliss, D.; Schmidt, B. [Research School of Astronomy and Astrophysics, Australian National University, Canberra, ACT 2611 (Australia); Penev, K.; Bakos, G. Á.; Hartman, J. D.; Csubry, Z. [Department of Astrophysical Sciences, Princeton University, NJ 08544 (United States); Jordán, A.; Brahm, R.; Rabus, M.; Suc, V.; Espinoza, N. [Departamento de Astronomía y Astrofísica, Pontificia Universidad Católica de Chile, Av. Vicuña Mackenna 4860, 7820436 Macul, Santiago (Chile); Mancini, L.; Mohler, M.; Ciceri, S.; Henning, T. [Max Planck Institute for Astronomy, Heidelberg (Germany); Buchhave, L. [Niels Bohr Institute, Copenhagen University (Denmark); Béky, B.; Noyes, R. W. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Butler, R. P., E-mail: george.zhou@anu.edu.au [Department of Terrestrial Magnetism, Carnegie Institution of Washington, 5241 Broad Branch Road NW, Washington, DC 20015-1305 (United States); and others

    2014-06-01

    We report the discovery of HATS-5b, a transiting hot Saturn orbiting a G-type star, by the HATSouth survey. HATS-5b has a mass of M{sub p} ≈ 0.24 M {sub J}, radius of R{sub p} ≈ 0.91 R {sub J}, and transits its host star with a period of P ≈ 4.7634 days. The radius of HATS-5b is consistent with both theoretical and empirical models. The host star has a V-band magnitude of 12.6, mass of 0.94 M {sub ☉}, and radius of 0.87 R {sub ☉}. The relatively high scale height of HATS-5b and the bright, photometrically quiet host star make this planet a favorable target for future transmission spectroscopy follow-up observations. We reexamine the correlations in radius, equilibrium temperature, and metallicity of the close-in gas giants and find hot Jupiter-mass planets to exhibit the strongest dependence between radius and equilibrium temperature. We find no significant dependence in radius and metallicity for the close-in gas giant population.

  18. Atmospheric circulation of eccentric hot Jupiter HAT-P-2B

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, Nikole K. [Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Showman, Adam P. [Department of Planetary Sciences and Lunar and Planetary Laboratory, The University of Arizona, Tucson, AZ 85721 (United States); Fortney, Jonathan J. [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Knutson, Heather A. [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States); Marley, Mark S., E-mail: nklewis@mit.edu [NASA Ames Research Center 245-3, Moffett Field, CA 94035 (United States)

    2014-11-10

    The hot Jupiter HAT-P-2b has become a prime target for Spitzer Space Telescope observations aimed at understanding the atmospheric response of exoplanets on highly eccentric orbits. Here we present a suite of three-dimensional atmospheric circulation models for HAT-P-2b that investigate the effects of assumed atmospheric composition and rotation rate on global scale winds and thermal patterns. We compare and contrast atmospheric models for HAT-P-2b, which assume one and five times solar metallicity, both with and without TiO/VO as atmospheric constituents. Additionally we compare models that assume a rotation period of half, one, and two times the nominal pseudo-synchronous rotation period. We find that changes in assumed atmospheric metallicity and rotation rate do not significantly affect model predictions of the planetary flux as a function of orbital phase. However, models in which TiO/VO are present in the atmosphere develop a transient temperature inversion between the transit and secondary eclipse events that results in significant variations in the timing and magnitude of the peak of the planetary flux compared with models in which TiO/VO are omitted from the opacity tables. We find that no one single atmospheric model can reproduce the recently observed full orbit phase curves at 3.6, 4.5 and 8.0 μm, which is likely due to a chemical process not captured by our current atmospheric models for HAT-P-2b. Further modeling and observational efforts focused on understanding the chemistry of HAT-P-2b's atmosphere are needed and could provide key insights into the interplay between radiative, dynamical, and chemical processes in a wide range of exoplanet atmospheres.

  19. Clinical study on HAT and SEDAN score scales and related risk factors for predicting hemorrhagic transformation following thrombolysis in acute ischemic stroke

    Directory of Open Access Journals (Sweden)

    Heng WEI

    2015-03-01

    Full Text Available Objective To investigate the value of HAT and SEDAN score scales in predicting hemorrhagic transformation (HT following the recombinant tissue-type plasminogen activator (rt-PA intravenous thrombolysis in acute ischemic stroke patients and risk factors affecting HT.  Methods A total of 143 patients with acute ischemic stroke underwent rt-PA intravenous thrombolysis within 4.50 h of onset and their clinical data were collected. According to head CT after thrombolysis, patients were divided into HT group (18 cases and non-HT group (125 cases. Single factor analysis was used to assess differences in HAT and SEDAN score scales and related risk factors of ischemic stroke in 2 groups, and further Logistic regression analysis was used to investigate independent predictors of HT. Receiver operating characteristic (ROC curve was used to evaluate the sensitivity and specificity of HAT and SEDAN score scales in predicting HT.  Results Univariate Logistic regression analysis showed that history of atrial fibrillation (AF, admission systolic blood pressure (SBP, admission blood glucose level, early low density of head CT, thrombolytic time window, National Institute of Health Stroke Scale (NIHSS, HAT and SEDAN scores were all risk factors for HT after thrombolysis (P < 0.05, for all. Multivariate Logistic regression analysis showed that history of AF (OR = 1.677, 95% CI: 1.332-2.111; P = 0.000, admission SBP (OR = 1.102, 95% CI: 1.009-1.204; P = 0.031, admission blood glucose level (OR = 1.870, 95% CI: 1.119-3.125; P = 0.017, thrombolysis time window (OR = 1.030, 95%CI: 1.009-1.052; P = 0.005, NIHSS score (OR = 1.574, 95%CI: 1.186-2.090; P = 0.002, HAT score (OR = 2.515, 95%CI: 1.273-4.970;P = 0.008 and SEDAN score (OR = 2.413, 95%CI: 1.123-5.185; P = 0.024 were risk factors for HT after thrombolysis. ROC curve analysis showed that HAT score could predict HT with 94.40% sensitivity and 41.60% specificity, and area under curve (AUC was 0.70. SEDAN

  20. How a hat may affect 3-month-olds' recognition of a face: an eye-tracking study.

    Directory of Open Access Journals (Sweden)

    Hermann Bulf

    Full Text Available Recent studies have shown that infants' face recognition rests on a robust face representation that is resilient to a variety of facial transformations such as rotations in depth, motion, occlusion or deprivation of inner/outer features. Here, we investigated whether 3-month-old infants' ability to represent the invariant aspects of a face is affected by the presence of an external add-on element, i.e. a hat. Using a visual habituation task, three experiments were carried out in which face recognition was investigated by manipulating the presence/absence of a hat during face encoding (i.e. habituation phase and face recognition (i.e. test phase. An eye-tracker system was used to record the time infants spent looking at face-relevant information compared to the hat. The results showed that infants' face recognition was not affected by the presence of the external element when the type of the hat did not vary between the habituation and test phases, and when both the novel and the familiar face wore the same hat during the test phase (Experiment 1. Infants' ability to recognize the invariant aspects of a face was preserved also when the hat was absent in the habituation phase and the same hat was shown only during the test phase (Experiment 2. Conversely, when the novel face identity competed with a novel hat, the hat triggered the infants' attention, interfering with the recognition process and preventing the infants' preference for the novel face during the test phase (Experiment 3. Findings from the current study shed light on how faces and objects are processed when they are simultaneously presented in the same visual scene, contributing to an understanding of how infants respond to the multiple and composite information available in their surrounding environment.

  1. How a hat may affect 3-month-olds' recognition of a face: an eye-tracking study.

    Science.gov (United States)

    Bulf, Hermann; Valenza, Eloisa; Turati, Chiara

    2013-01-01

    Recent studies have shown that infants' face recognition rests on a robust face representation that is resilient to a variety of facial transformations such as rotations in depth, motion, occlusion or deprivation of inner/outer features. Here, we investigated whether 3-month-old infants' ability to represent the invariant aspects of a face is affected by the presence of an external add-on element, i.e. a hat. Using a visual habituation task, three experiments were carried out in which face recognition was investigated by manipulating the presence/absence of a hat during face encoding (i.e. habituation phase) and face recognition (i.e. test phase). An eye-tracker system was used to record the time infants spent looking at face-relevant information compared to the hat. The results showed that infants' face recognition was not affected by the presence of the external element when the type of the hat did not vary between the habituation and test phases, and when both the novel and the familiar face wore the same hat during the test phase (Experiment 1). Infants' ability to recognize the invariant aspects of a face was preserved also when the hat was absent in the habituation phase and the same hat was shown only during the test phase (Experiment 2). Conversely, when the novel face identity competed with a novel hat, the hat triggered the infants' attention, interfering with the recognition process and preventing the infants' preference for the novel face during the test phase (Experiment 3). Findings from the current study shed light on how faces and objects are processed when they are simultaneously presented in the same visual scene, contributing to an understanding of how infants respond to the multiple and composite information available in their surrounding environment. PMID:24349378

  2. HATS-17b: A Transiting Compact Warm Jupiter in a 16.3 Day Circular Orbit

    Science.gov (United States)

    Brahm, R.; Jordán, A.; Bakos, G. Á.; Penev, K.; Espinoza, N.; Rabus, M.; Hartman, J. D.; Bayliss, D.; Ciceri, S.; Zhou, G.; Mancini, L.; Tan, T. G.; de Val-Borro, M.; Bhatti, W.; Csubry, Z.; Bento, J.; Henning, T.; Schmidt, B.; Rojas, F.; Suc, V.; Lázár, J.; Papp, I.; Sári, P.

    2016-04-01

    We report the discovery of HATS-17b, the first transiting warm Jupiter of the HATSouth network. HATS-17b transits its bright (V = 12.4) G-type ({M}\\star = 1.131+/- 0.030 {M}⊙ , {R}\\star = {1.091}-0.046+0.070 {R}⊙ ) metal-rich ([Fe/H] = +0.3 dex) host star in a circular orbit with a period of P = 16.2546 days. HATS-17b has a very compact radius of 0.777+/- 0.056 {R}{{J}} given its Jupiter-like mass of 1.338+/- 0.065 {M}{{J}}. Up to 50% of the mass of HATS-17b may be composed of heavy elements in order to explain its high density with current models of planetary structure. HATS-17b is the longest period transiting planet discovered to date by a ground-based photometric survey, and is one of the brightest transiting warm Jupiter systems known. The brightness of HATS-17 will allow detailed follow-up observations to characterize the orbital geometry of the system and the atmosphere of the planet. The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia Universidad Católica de Chile (PUC). The station at Las Campanas Observatory (LCO) of the Carnegie Institute is operated by PU in conjunction with PUC, the station at the High Energy Spectroscopic Survey (H.E.S.S.) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU. This paper includes data gathered with the MPG 2.2 m telescope at the ESO Observatory in La Silla and with the 3.9 m AAT in Siding Spring Observatory. This paper uses observations obtained with facilities of the Las Cumbres Observatory Global Telescope. Based on observations taken with the HARPS spectrograph (ESO 3.6 m telescope at La Silla) under programme 097.C-0571.

  3. Non-integrating episomal plasmid-based reprogramming of human amniotic fluid stem cells into induced pluripotent stem cells in chemically defined conditions.

    Science.gov (United States)

    Slamecka, Jaroslav; Salimova, Lilia; McClellan, Steven; van Kelle, Mathieu; Kehl, Debora; Laurini, Javier; Cinelli, Paolo; Owen, Laurie; Hoerstrup, Simon P; Weber, Benedikt

    2016-01-01

    Amniotic fluid stem cells (AFSC) represent an attractive potential cell source for fetal and pediatric cell-based therapies. However, upgrading them to pluripotency confers refractoriness toward senescence, higher proliferation rate and unlimited differentiation potential. AFSC were observed to rapidly and efficiently reacquire pluripotency which together with their easy recovery makes them an attractive cell source for reprogramming. The reprogramming process as well as the resulting iPSC epigenome could potentially benefit from the unspecialized nature of AFSC. iPSC derived from AFSC also have potential in disease modeling, such as Down syndrome or β-thalassemia. Previous experiments involving AFSC reprogramming have largely relied on integrative vector transgene delivery and undefined serum-containing, feeder-dependent culture. Here, we describe non-integrative oriP/EBNA-1 episomal plasmid-based reprogramming of AFSC into iPSC and culture in fully chemically defined xeno-free conditions represented by vitronectin coating and E8 medium, a system that we found uniquely suited for this purpose. The derived AF-iPSC lines uniformly expressed a set of pluripotency markers Oct3/4, Nanog, Sox2, SSEA-1, SSEA-4, TRA-1-60, TRA-1-81 in a pattern typical for human primed PSC. Additionally, the cells formed teratomas, and were deemed pluripotent by PluriTest, a global expression microarray-based in-silico pluripotency assay. However, we found that the PluriTest scores were borderline, indicating a unique pluripotent signature in the defined condition. In the light of potential future clinical translation of iPSC technology, non-integrating reprogramming and chemically defined culture are more acceptable.

  4. High multiplicity processes at NLO with BlackHat and Sherpa

    CERN Document Server

    Bern, Zvi; Dixon, Lance J; Hoeche, Stefan; Cordero, Fernando Febres; Ita, Harald; Kosower, David; Maître, Daniel

    2012-01-01

    In this contribution we review recent progress with fixed-order QCD predictions for the production of a vector boson in association with jets at hadron colliders, using the programs BlackHat and SHERPA. We review general features of next-to-leading-order (NLO) predictions for the production of a massive vector boson in association with four jets. We also discuss how precise descriptions of vector-boson production can be applied to the determination of backgrounds to new physics signals. Here we focus on data-driven backgrounds to a missing-energy-plus-jets search performed by CMS. Finally, we review recent progress in developing theoretical tools for high-multiplicity loop-computation within the BlackHat-library. In particular, we discuss methods for handling the color degrees of freedom in multi-jet predictions at NLO.

  5. Kepler's optical phase curve of the exoplanet HAT-P-7b.

    Science.gov (United States)

    Borucki, W J; Koch, D; Jenkins, J; Sasselov, D; Gilliland, R; Batalha, N; Latham, D W; Caldwell, D; Basri, G; Brown, T; Christensen-Dalsgaard, J; Cochran, W D; DeVore, E; Dunham, E; Dupree, A K; Gautier, T; Geary, J; Gould, A; Howell, S; Kjeldsen, H; Lissauer, J; Marcy, G; Meibom, S; Morrison, D; Tarter, J

    2009-08-01

    Ten days of photometric data were obtained during the commissioning phase of the Kepler mission, including data for the previously known giant transiting exoplanet HAT-P-7b. The data for HAT-P-7b show a smooth rise and fall of light from the planet as it orbits its star, punctuated by a drop of 130 +/- 11 parts per million in flux when the planet passes behind its star. We interpret this as the phase variation of the dayside thermal emission plus reflected light from the planet as it orbits its star and is occulted. The depth of the occultation is similar in photometric precision to the detection of a transiting Earth-size planet for which the mission was designed.

  6. Research on the Procedure for Computer-Aided Pattern Design of Uygur's Flowered Hats

    Directory of Open Access Journals (Sweden)

    Shuxian Liu

    2013-05-01

    Full Text Available Xinjiang Uygur’s flowered hats is famous all over the world, it leads the world of headwear of variou nationalities within China by the variety of styles, the various ways of how to emroider pattern design and exquisite manufacture. It is unusual even in national costumes art of the world. The poupose of this study is to analyze Uygur's headwear, study the rules of Uygur's headwear pattern, analyze the characteristic of the basic pattern, research on the procedure for computer-aided pattern design of Uygur's flowered hat, explore the application of computer-aided design in traditional costume's pattern design and to realize application exploration of computer-aided design in designing of costume and dress adornment.

  7. Potential ground water resources of Hat Yai Basin in Peninsular Thailand by gravity study

    Directory of Open Access Journals (Sweden)

    Warawutti Lohawijarn

    2005-05-01

    Full Text Available Residual gravity anomaly with a minimum of about -140 mm s-2 with approximately NS trend and a limited axial length was observed over Hat Yai Basin in Peninsular Thailand. The modeled Hat Yai basin is about 1 km deep at its deepest, 60 km long and 20 km wide. The porosity of basin sediment and the amount of potential ground water reserves within the basin are estimated to be 39% and 121.7±0.8 km3 respectively, assuming full saturation. Within the topmost 80 m of ground where the present extraction is concentrated, the estimated ground water reserve is 12.5±0.5 km3.

  8. High-power Er:YAG laser with quasi-top-hat output beam.

    Science.gov (United States)

    Kim, J W; Mackenzie, J I; Hayes, J R; Clarkson, W A

    2012-05-01

    A simple method for simultaneously exciting the fundamental (TEM00) transverse mode and first order Laguerre-Gaussian (LG01) donut mode in an end-pumped solid-state laser to yield a quasi-top-hat output beam is reported. This approach has been applied to an Er:YAG laser, in-band pumped by an Er,Yb fiber laser, yielding 9.6 W of continuous-wave output at 1645 nm in a top-hat-like beam with beam propagation factor (M2)<2.1 for 24 W of incident pump power at 1532 nm. The corresponding slope efficiency with respect to incident pump power was 49%. The prospects of further scaling of output power and improved overall efficiency are considered.

  9. Origin of the Napoleon's hat nebula around SN1987A and implications for the progenitor

    Science.gov (United States)

    Podsiadlowski, Ph.; Fabian, A. C.; Stevens, I. R.

    1991-11-01

    A simple geometrical model for the emission nebula around SN1987A, whose morphology has been likened to Napoleon's hat, is presented. The model consists of a ring and a truncated double cone. When the effects of light travel time are included, the model reproduces the important topological structures of the nebula and makes detailed quantitative predictions for its future appearance. In particular, the hat-shaped northern rim is simply explained as the interaction of the light front with the northern cone. To explain the origin of the double cone, it is argued that the progenitor of SN1987A was in a binary system: its strong wind, colliding with a weaker wind from the companion star, created an asymptotic shock surface that was spread out into the required geometry by the rotation of the binary.

  10. Detection of Point Sources in Cosmic Ray Maps using the Mexican Hat Wavelet Family

    CERN Document Server

    Batista, Rafael Alves; Daniel, Bruno; 10.1142/S0218301311040608

    2012-01-01

    An analysis of the sensitivity of gaussian and mexican hat wavelet family filters to the detection of point sources of ultra-high energy cosmic rays was performed. A source embedded in a background was simulated and the number of events and amplitude of this source was varied aiming to check the sensitivity of the method to detect faint sources with low statistic of events.

  11. Conformal blocks related to the R-R states in the \\hat c =1 SCFT

    CERN Document Server

    Hadasz, Leszek; Suchanek, Paulina

    2007-01-01

    We derive an explicit form of a family of four-point Neveu-Schwarz blocks with $\\hat c =1,$ external weights $\\Delta_i = 1/8$ and arbitrary intermediate weight. The derivation is based on a set of identities obeyed in the free superscalar theory by correlation functions of fields satisfying Ramond condition with respect to the bosonic (dimension 1) and the fermionic (dimension 1/2) currents.

  12. HAT-P-26b: A Neptune-mass Exoplanet with Primordial Solar Heavy Element Abundance

    Science.gov (United States)

    Wakeford, Hannah; Sing, David; Deming, Drake; Kataria, Tiffany; Lopez, Eric

    2016-10-01

    A trend in giant planet mass and atmospheric heavy elemental abundance was first noted last century from observations of planets in our own solar system. These four data points from Jupiter, Saturn, Uranus, and Neptune have served as a corner stone of planet formation theory. Here we add another point in the mass-metallicity trend from a detailed observational study of the extrasolar planet HAT-P-26b, which inhabits the critical mass regime near Neptune and Uranus. Neptune-sized worlds are among the most common planets in our galaxy and frequently exist in orbital periods very different from that of our own solar system ice giants. Atmospheric studies are the principal window into these worlds, and thereby into their formation and evolution, beyond those of our own solar system. Using the Hubble Space Telescope and Spitzer, from the optical to the infrared, we conducted a detailed atmospheric study of the Neptune-mass exoplanet HAT-P-26b over 0.5 to 4.5 μm. We detect prominent H2O absorption at 1.4 μm to 525 ppm in the atmospheric transmission spectrum. We determine that HAT-P-26b's atmosphere is not rich in heavy elements (≈1.8×solar), which goes distinctly against the solar system mass-metallicity trend. This likely indicates that HAT-P-26b's atmosphere is primordial and obtained its gaseous envelope late in its disk lifetime with little contamination from metal-rich planetesimals.

  13. Home Automated Telemanagement (HAT) System to Facilitate Self-Care of Patients with Chronic Diseases

    OpenAIRE

    Joseph Finkelstein; Rajesh Khare; Deepal Vora

    2003-01-01

    Successful patient self-management requires a multidisciplinary approach that includes regular patient assessment, disease-specific education, control of medication adherence, implementation of health behavior change models and social support. Existing systems for computer-assisted disease management do not provide this multidisciplinary patient support and do not address treatment compliance issues. We developed the Home Automated Telemanagement (HAT) system for patients with different chron...

  14. Self-assembled ordered structures in thin films of HAT5 discotic liquid crystal

    OpenAIRE

    Piero Morales; Jan Lagerwall; Paolo Vacca; Sabine Laschat; Giusy Scalia

    2010-01-01

    Thin films of the discotic liquid crystal hexapentyloxytriphenylene (HAT5), prepared from solution via casting or spin-coating, were investigated by atomic force microscopy and polarizing optical microscopy, revealing large-scale ordered structures substantially different from those typically observed in standard samples of the same material. Thin and very long fibrils of planar-aligned liquid crystal were found, possibly formed as a result of an intermediate lyotropic nematic state arising d...

  15. HATS-4b: A Dense Hot-Jupiter Transiting a Super Metal-Rich G Star

    CERN Document Server

    Jordán, A; Bakos, G Á; Bayliss, D; Penev, K; Hartman, J D; Zhou, G; Mancini, L; Mohler-Fischer, M; Ciceri, S; Sato, B; Csubry, Z; Rabus, M; Suc, V; Espinoza, N; Bhatti, W; Borro, M de Val; Buchhave, L; Csák, B; Henning, T; Schmidt, B; Tan, T G; Noyes, R W; Béky, B; Butler, R P; Shectman, S; Crane, J; Thompson, I; Williams, A; Martin, R; Contreras, C; Lázár, J; Papp, I; Sári, P

    2014-01-01

    We report the discovery by the HATSouth survey of HATS-4b, an extrasolar planet transiting a V=13.46 mag G star. HATS-4b has a period of P = 2.5167 d, mass of Mp = 1.32 Mj, radius of Rp = 1.02 Rj and density of rho_p = 1.55 +- 0.16 g/cm^3 ~ 1.24 rhoj. The host star has a mass of 1.00 Msun, a radius of 0.92 Rsun and a very high metallicity [Fe/H]= 0.43 +- 0.08. HATS-4b is among the densest known planets with masses between 1-2 Mj and is thus likely to have a significant content of heavy elements of the order of 75 Mearth. In this paper we present the data reduction, radial velocity measurement and stellar classification techniques adopted by the HATSouth survey for the CORALIE spectrograph. We also detail a technique to estimate simultaneously vsini and macroturbulence using high resolution spectra.

  16. iHAT: interactive Hierarchical Aggregation Table for Genetic Association Data

    Directory of Open Access Journals (Sweden)

    Heinrich Julian

    2012-05-01

    Full Text Available Abstract In the search for single-nucleotide polymorphisms which influence the observable phenotype, genome wide association studies have become an important technique for the identification of associations between genotype and phenotype of a diverse set of sequence-based data. We present a methodology for the visual assessment of single-nucleotide polymorphisms using interactive hierarchical aggregation techniques combined with methods known from traditional sequence browsers and cluster heatmaps. Our tool, the interactive Hierarchical Aggregation Table (iHAT, facilitates the visualization of multiple sequence alignments, associated metadata, and hierarchical clusterings. Different color maps and aggregation strategies as well as filtering options support the user in finding correlations between sequences and metadata. Similar to other visualizations such as parallel coordinates or heatmaps, iHAT relies on the human pattern-recognition ability for spotting patterns that might indicate correlation or anticorrelation. We demonstrate iHAT using artificial and real-world datasets for DNA and protein association studies as well as expression Quantitative Trait Locus data.

  17. Detection of the Secondary Eclipse of Exoplanet HAT P-11b

    Science.gov (United States)

    Barry, R. K.; Deming, L. D.; Bakos, G.; Harrington, J.; Madhusudhan, N.; Noyes, R.; Seager, S.

    2010-01-01

    We have successfully conducted secondary eclipse observations of exoplanet HAT-P-11b using the Spitzer Space Telescope. HAT-P-11b was, until very recently, the smallest transiting extrasolar planet yet found and one of only two known exo-Neptunes. We observed the system at 3.6 microns for a period of 22 hours centered on the anticipated secondary eclipse time, to detect the eclipse and determine its phase. Having detected the secondary eclipse, we are at present making a more focused series of observations in both the 3.6 and 4.5 micron bands to fully characterize it. HAT-P-11b has a period of 4.8878 days, radius of 0.422 RJ, mass of 0.081 MJ and semi-major axis 0.053 AU. Measurements of the secondary eclipse will serve to clarify two key issues; 1) the planetary brightness temperature and the nature of its atmosphere, and 2) the eccentricity of its orbit, with implications for its dynamical evolution. A precise determination of the orbit phase for the secondary eclipse will also be of great utility for Kepler observations of this system at visible wavelengths.

  18. A spin-orbit alignment for the hot Jupiter HATS-3b

    Energy Technology Data Exchange (ETDEWEB)

    Addison, B. C.; Tinney, C. G.; Wright, D. J. [Exoplanetary Science Group, School of Physics, University of New South Wales, Sydney, NSW 2052 (Australia); Bayliss, D., E-mail: b.addison@unsw.edu.au [Research School of Astronomy and Astrophysics, Australian National University, Canberra, ACT 2611 (Australia)

    2014-09-10

    We have measured the alignment between the orbit of HATS-3b (a recently discovered, slightly inflated Hot Jupiter) and the spin axis of its host star. Data were obtained using the CYCLOPS2 optical-fiber bundle and its simultaneous calibration system feeding the UCLES spectrograph on the Anglo-Australian Telescope. The sky-projected spin-orbit angle of λ = 3° ± 25° was determined from spectroscopic measurements of the Rossiter-McLaughlin effect. This is the first exoplanet discovered through the HATSouth transit survey to have its spin-orbit angle measured. Our results indicate that the orbital plane of HATS-3b is consistent with being aligned to the spin axis of its host star. The low obliquity of the HATS-3 system, which has a relatively hot mid F-type host star, agrees with the general trend observed for Hot Jupiter host stars with effective temperatures >6250 K to have randomly distributed spin-orbit angles.

  19. The refined physical parameters of transiting exoplanet system HAT-P-24

    Institute of Scientific and Technical Information of China (English)

    Xiao-Bin Wang; Sheng-Hong Gu; Andrew Collier Cameron; Hong-Bo Tan; Ho-Keung Hui; Chi-Tai Kwok; Bill Yeung

    2013-01-01

    The transiting exoplanet system HAT-P-24 was observed by using CCD cameras at Yunnan Observatory and Hokoon Astronomical Centre,China in 2010 and 2012.In order to enhance the signal to noise ratio of transit events,the observed data are corrected for systematic errors according to Collier Cameron et al.'s coarse decorrelation and Tamuz et al.'s SYSREM algorithms.Three new complete transit light curves are analyzed by means of the Markov chain Monte Carlo technique,and the new physical parameters of the system are derived.They are consistent with the old ones from the discovered paper except for a new larger radius RP =1.364 RJ of HAT-P-24b,which confirms its inflated nature.By combining the five available epochs of mid-transit derived from complete transit light curves,the orbital period of HAT-P-24b is refined to P =3.3552479 d and no obvious transit timing variation signal can be found from these five transit events during 2010-2012.

  20. Atmospheric Circulation of Eccentric Hot Jupiter HAT-P-2b

    CERN Document Server

    Lewis, Nikole K; Fortney, Jonathan J; Knutson, Heather A; Marley, Mark S

    2014-01-01

    The hot-Jupiter HAT-P-2b has become a prime target for Spitzer Space Telescope observations aimed at understanding the atmospheric response of exoplanets on highly eccentric orbits. Here we present a suite of three-dimensional atmospheric circulation models for HAT-P-2b that investigate the effects of assumed atmospheric composition and rotation rate on global scale winds and thermal patterns. We compare and contrast atmospheric models for HAT-P-2b, which assume one and five times solar metallicity, both with and without TiO/VO as atmospheric constituents. Additionally we compare models that assume a rotation period of half, one, and two times the nominal pseudo-synchronous rotation period. We find that changes in assumed atmospheric metallicity and rotation rate do not significantly affect model predictions of the planetary flux as a function of orbital phase. However, models in which TiO/VO are present in the atmosphere develop a transient temperature inversion between the transit and secondary eclipse even...

  1. A spin-orbit alignment for the hot Jupiter HATS-3b

    International Nuclear Information System (INIS)

    We have measured the alignment between the orbit of HATS-3b (a recently discovered, slightly inflated Hot Jupiter) and the spin axis of its host star. Data were obtained using the CYCLOPS2 optical-fiber bundle and its simultaneous calibration system feeding the UCLES spectrograph on the Anglo-Australian Telescope. The sky-projected spin-orbit angle of λ = 3° ± 25° was determined from spectroscopic measurements of the Rossiter-McLaughlin effect. This is the first exoplanet discovered through the HATSouth transit survey to have its spin-orbit angle measured. Our results indicate that the orbital plane of HATS-3b is consistent with being aligned to the spin axis of its host star. The low obliquity of the HATS-3 system, which has a relatively hot mid F-type host star, agrees with the general trend observed for Hot Jupiter host stars with effective temperatures >6250 K to have randomly distributed spin-orbit angles.

  2. Independent discovery and refined parameters of the transiting exoplanet HAT-P-14b

    CERN Document Server

    Simpson, E K; Brown, D J A; Cameron, A Collier; Pollacco, D; Skillen, I; Stempels, H C; Boisse, I; Faedi, F; Hebrard, G; McCormac, J; Sorensen, P; Street, R A; Bento, J; Bouchy, F; Butters, O W; Enoch, B; Haswell, C A; Hebb, L; Holmes, S; Horne, K; Keenan, F P; Lister, T A; Miller, G R M; Moulds, V; Moutou, C; Norton, A J; Parley, N; Santerne, A; Todd, I; Watson, C A; West, R G; Wheatley, P J

    2010-01-01

    We present SuperWASP observations of HAT-P-14b, a hot Jupiter discovered by Torres et al. The planet was found independently by the SuperWASP team and named WASP-27b after follow-up observations had secured the discovery, but prior to the publication by Torres et al. Our analysis of HAT-P-14/WASP-27 is in good agreement with the values found by Torres et al. and we refine the parameters by combining our datasets. We also provide additional evidence against astronomical false positives. Due to the brightness of the host star, V = 10, HAT-P-14 is an attractive candidate for further characterisation observations. The planet has a high impact parameter, b = 0.907 +/- 0.004, and the primary transit is close to grazing. This could readily reveal small deviations in the orbital parameters indicating the presence of a third body in the system, which may be causing the small but significant orbital eccentricity, e = 0.095 +/- 0.011. The system geometry suggests that the planet narrowly fails to undergo a secondary ecl...

  3. HATS-18 b: An Extreme Short--Period Massive Transiting Planet Spinning Up Its Star

    CERN Document Server

    Penev, Dr Kaloyan M; Bakos, Dr Gaspar A; Ciceri, Ms Simona; Brahm, Dr Rafael; Bayliss, Dr Daniel; Bento, Joao; Jord'an, Andr'es; Csubry, Mr Zoltan; Bhatti, W; de Val-Borro, Miguel; Espinoza, Mr Néstor; Zhou, Dr George; Mancini, Dr Luigi; Rabus, Dr Markus; Suc, Vincent; Henning, Thomas; Schmidt, Prof Brian P; Noyes, Dr Robert W; L'az'ar, J; Papp, Istvan; S'ari, P

    2016-01-01

    We report the discovery by the HATSouth network of HATS-18 b: a 1.980 +/- 0.077 Mj, 1.337 +0.102 -0.049 Rj planet in a 0.8378 day orbit, around a solar analog star (mass 1.037 +/- 0.047 Msun, and radius 1.020 +0.057 -0.031 Rsun) with V=14.067 +/- 0.040 mag. The high planet mass, combined with its short orbital period, implies strong tidal coupling between the planetary orbit and the star. In fact, given its inferred age, HATS-18 shows evidence of significant tidal spin up, which together with WASP-19 (a very similar system) allows us to constrain the tidal quality factor for Sun-like stars to be in the range 6.5 <= lg(Q*/k_2) <= 7 even after allowing for extremely pessimistic model uncertainties. In addition, the HATS-18 system is among the best systems (and often the best system) for testing a multitude of star--planet interactions, be they gravitational, magnetic or radiative, as well as planet formation and migration theories.

  4. The refined physical parameters of transiting exoplanet system HAT-P-24

    International Nuclear Information System (INIS)

    The transiting exoplanet system HAT-P-24 was observed by using CCD cameras at Yunnan Observatory and Hokoon Astronomical Centre, China in 2010 and 2012. In order to enhance the signal to noise ratio of transit events, the observed data are corrected for systematic errors according to Collier Cameron et al.'s coarse de-correlation and Tamuz et al.'s SYSREM algorithms. Three new complete transit light curves are analyzed by means of the Markov chain Monte Carlo technique, and the new physical parameters of the system are derived. They are consistent with the old ones from the discovered paper except for a new larger radius Rp = 1.364 RJ of HAT-P-24b, which confirms its inflated nature. By combining the five available epochs of mid-transit derived from complete transit light curves, the orbital period of HAT-P-24b is refined to P = 3.3552479 d and no obvious transit timing variation signal can be found from these five transit events during 2010–2012

  5. Image registration algorithm using Mexican hat function-based operator and grouped feature matching strategy.

    Directory of Open Access Journals (Sweden)

    Feng Jin

    Full Text Available Feature detection and matching are crucial for robust and reliable image registration. Although many methods have been developed, they commonly focus on only one class of image features. The methods that combine two or more classes of features are still novel and significant. In this work, methods for feature detection and matching are proposed. A Mexican hat function-based operator is used for image feature detection, including the local area detection and the feature point detection. For the local area detection, we use the Mexican hat operator for image filtering, and then the zero-crossing points are extracted and merged into the area borders. For the feature point detection, the Mexican hat operator is performed in scale space to get the key points. After the feature detection, an image registration is achieved by using the two classes of image features. The feature points are grouped according to a standardized region that contains correspondence to the local area, precise registration is achieved eventually by the grouped points. An image transformation matrix is estimated by the feature points in a region and then the best one is chosen through competition of a set of the transformation matrices. This strategy has been named the Grouped Sample Consensus (GCS. The GCS has also ability for removing the outliers effectively. The experimental results show that the proposed algorithm has high registration accuracy and small computational volume.

  6. Formulating robust linear regression estimation as a one-class LDA criterion: discriminative hat matrix.

    Science.gov (United States)

    Dufrenois, F; Noyer, J C

    2013-02-01

    Linear discriminant analysis, such as Fisher's criterion, is a statistical learning tool traditionally devoted to separating a training dataset into two or even several classes by the way of linear decision boundaries. In this paper, we show that this tool can formalize the robust linear regression problem as a robust estimator will do. More precisely, we develop a one-class Fischer's criterion in which the maximization provides both the regression parameters and the separation of the data in two classes: typical data and atypical data or outliers. This new criterion is built on the statistical properties of the subspace decomposition of the hat matrix. From this angle, we improve the discriminative properties of the hat matrix which is traditionally used as outlier diagnostic measure in linear regression. Naturally, we call this new approach discriminative hat matrix. The proposed algorithm is fully nonsupervised and needs only the initialization of one parameter. Synthetic and real datasets are used to study the performance both in terms of regression and classification of the proposed approach. We also illustrate its potential application to image recognition and fundamental matrix estimation in computer vision.

  7. Reconstruction-by-Dilation and Top-Hat Algorithms for Contrast Enhancement and Segmentation of Microcalcifications in Digital Mammograms

    Science.gov (United States)

    Diaz, Claudia C.

    2007-11-01

    I present some results of contrast enhancement and segmentation of microcalcifications in digital mammograms. These mammograms were obtained from MIAS-minidatabase and using a CR to digitize images. White-top-hat and black-top-hat transformations were used to improve the contrast of images, while reconstruction-by-dilation algorithm was used to emphasize the microcalcifications over the tissues. Segmentation was done using different gradient matrices. These algorithms intended to show some details which were not evident in original images.

  8. Spin orbit alignment for KELT-7b and HAT-P-56b via Doppler tomography with TRES

    CERN Document Server

    Zhou, George; Bieryla, Allyson; Beatty, Thomas G; Buchhave, Lars A; Esquerdo, Gilbert A; Berlind, Perry; Calkins, Michael L

    2016-01-01

    We present Doppler tomographic analyses for the spectroscopic transits of KELT-7b and HAT-P-56b, two hot-Jupiters orbiting rapidly rotating F-dwarf host stars. These include analyses of archival TRES observations for KELT-7b, and a new TRES transit observation of HAT-P-56b. We report spin-orbit aligned geometries for KELT-7b (2.7 +/- 0.6 deg) and HAT-P-56b (8 +/- 2 deg). The host stars KELT-7 and HAT-P-56 are among some of the most rapidly rotating planet-hosting stars known. We examine the tidal re-alignment model for the evolution of the spin-orbit angle in the context of the spin rates of these stars. We find no evidence that the rotation rates of KELT-7 and HAT-P-56 have been modified by star-planet tidal interactions, suggesting that the spin-orbit angle of systems around these hot stars may represent their primordial configuration. In fact, KELT-7 and HAT-P-56 are two of three systems in super-synchronous, spin-orbit aligned states, where the rotation periods of the host stars are faster than the orbita...

  9. Spin-orbit alignment for KELT-7b and HAT-P-56b via Doppler tomography with TRES

    Science.gov (United States)

    Zhou, George; Latham, David W.; Bieryla, Allyson; Beatty, Thomas G.; Buchhave, Lars A.; Esquerdo, Gilbert A.; Berlind, Perry; Calkins, Michael L.

    2016-08-01

    We present Doppler tomographic analyses for the spectroscopic transits of KELT-7b and HAT-P-56b, two hot-Jupiters orbiting rapidly rotating F-dwarf host stars. These include analyses of archival Tillinghast Reflector Echelle Spectrograph (TRES) observations for KELT-7b, and a new TRES transit observation of HAT-P-56b. We report spin-orbit aligned geometries for KELT-7b (2.7° ± 0.6°) and HAT-P-56b (8° ± 2°). The host stars KELT-7 and HAT-P-56 are among some of the most rapidly rotating planet-hosting stars known. We examine the tidal re-alignment model for the evolution of the spin-orbit angle in the context of the spin rates of these stars. We find no evidence that the rotation rates of KELT-7 and HAT-P-56 have been modified by star-planet tidal interactions, suggesting that the spin-orbit angle of systems around these hot stars may represent their primordial configuration. In fact, KELT-7 and HAT-P-56 are two of three systems in supersynchronous, spin-orbit aligned states, where the rotation periods of the host stars are faster than the orbital periods of the planets.

  10. Characterization of the atmosphere of the hot Jupiter HAT-P-32Ab and the M-dwarf companion HAT-P-32B

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Ming; Wright, Jason T.; Curtis, Jason [Department of Astronomy and Astrophysics, Pennsylvania State University, PA 16802 (United States); O' Rourke, Joseph G.; Knutson, Heather A.; Ngo, Henry [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States); Burrows, Adam [Department of Astrophysical Sciences, Princeton University, 4 Ivy Lane, Princeton, NJ 08544 (United States); Fortney, Johnathan [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Fulton, Benjamin J.; Baranec, Christoph [Institute for Astronomy, University of Hawai' i at Mānoa, Hilo, HI 96720-2700 (United States); Riddle, Reed; Hinkley, Sasha [Division of Physics, Mathematics, and Astronomy, California Institute of Technology, Pasadena, CA 91125 (United States); Law, Nicholas M. [Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3255 (United States); Muirhead, Philip S. [Department of Astronomy, Boston University, 725 Commonwealth Avenue, Boston, MA 02215 (United States); Showman, Adam P. [Department of Planetary Sciences and Lunar and Planetary Laboratory, The University of Arizona, Tucson, AZ 85721 (United States); Burruss, Rick, E-mail: mingzhao@psu.edu [Jet Propulsion Laboratory, California Institute of Technology, CA 91109 (United States)

    2014-12-01

    We report secondary eclipse photometry of the hot Jupiter HAT-P-32Ab, taken with Hale/Wide-field Infra-Red Camera (WIRC) in H and K{sub S} bands and with Spitzer/IRAC at 3.6 and 4.5 μm. We carried out adaptive optics imaging of the planet host star HAT-P-32A and its companion HAT-P-32B in the near-IR and the visible. We clearly resolve the two stars from each other and find a separation of 2.''923 ± 0.''004 and a position angle 110.°64 ± 0.°12. We measure the flux ratios of the binary in g'r'i'z' and H and K{sub S} bands, and determine T {sub eff}= 3565 ± 82 K for the companion star, corresponding to an M1.5 dwarf. We use PHOENIX stellar atmosphere models to correct the dilution of the secondary eclipse depths of the hot Jupiter due to the presence of the M1.5 companion. We also improve the secondary eclipse photometry by accounting for the non-classical, flux-dependent nonlinearity of the WIRC IR detector in the H band. We measure planet-to-star flux ratios of 0.090% ± 0.033%, 0.178% ± 0.057%, 0.364% ± 0.016%, and 0.438% ± 0.020% in the H, K{sub S} , 3.6 and 4.5 μm bands, respectively. We compare these with planetary atmospheric models, and find they prefer an atmosphere with a temperature inversion and inefficient heat redistribution. However, we also find that the data are equally well described by a blackbody model for the planet with T {sub p} = 2042 ± 50 K. Finally, we measure a secondary eclipse timing offset of 0.3 ± 1.3 minutes from the predicted mid-eclipse time, which constrains e = 0.0072{sub −0.0064}{sup +0.0700} when combined with radial velocity data and is more consistent with a circular orbit.

  11. HATS-18b: An Extreme Short-period Massive Transiting Planet Spinning Up Its Star

    Science.gov (United States)

    Penev, K.; Hartman, J. D.; Bakos, G. Á.; Ciceri, S.; Brahm, R.; Bayliss, D.; Bento, J.; Jordán, A.; Csubry, Z.; Bhatti, W.; de Val-Borro, M.; Espinoza, N.; Zhou, G.; Mancini, L.; Rabus, M.; Suc, V.; Henning, T.; Schmidt, B.; Noyes, R. W.; Lázár, J.; Papp, I.; Sári, P.

    2016-11-01

    We report the discovery by the HATSouth network of HATS-18b: a 1.980+/- 0.077 {M}{{J}}, {1.337}-0.049+0.102 {R}{{J}} planet in a 0.8378 day orbit, around a solar analog star (mass 1.037+/- 0.047 {M}ȯ and radius {1.020}-0.031+0.057 {R}ȯ ) with V=14.067+/- 0.040 mag. The high planet mass, combined with its short orbital period, implies strong tidal coupling between the planetary orbit and the star. In fact, given its inferred age, HATS-18 shows evidence of significant tidal spin up, which together with WASP-19 (a very similar system) allows us to constrain the tidal quality factor for Sun-like stars to be in the range of 6.5≲ {{log}}10({Q}* /{k}2)≲ 7 even after allowing for extremely pessimistic model uncertainties. In addition, the HATS-18 system is among the best systems (and often the best system) for testing a multitude of star–planet interactions, be they gravitational, magnetic, or radiative, as well as planet formation and migration theories. The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia Universidad Católica de Chile (PUC). The station at Las Campanas Observatory (LCO) of the Carnegie Institute is operated by PU in conjunction with PUC, the station at the High Energy Spectroscopic Survey (H.E.S.S.) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU. This paper includes data gathered with the MPG 2.2 m telescope at the ESO Observatory in La Silla. This paper uses observations obtained with facilities of the Las Cumbres Observatory Global Telescope.

  12. Hard Hats, Octopuses and Rubber Boots- Operational Managers in Building Processes

    DEFF Research Database (Denmark)

    Koch, Christian

    2004-01-01

    This paper discusses Operation management (OM) in the production of buildings. It is initially contended that OM needs to be improved, from a theoretical and practical perspective. Departing from a criticism of present modeling and management of processes it is suggested to develop an understandi...... for these disturbances was coordination problems, but generally most types of interdependencies proved problematic. The needed skills for the site managers thus become those of the octopus handling processes in parallel with the necessary equipment of hard hats and rubber boots....

  13. Calculating the Jet Transport Coefficient $\\hat{q}$ in Lattice Gauge Theory

    CERN Document Server

    Majumder, Abhijit

    2012-01-01

    The formalism of jet modification in the higher twist approach is modified to describe a hard parton propagating through a hot thermalized medium. The leading order contribution to the transverse momentum broadening of a high energy (near on-shell) quark in a thermal medium is calculated. This involves a factorization of the perturbative process of scattering of the quark from the non-perturbative transport coefficient. An operator product expansion of the non-perturbative operator product which represents $\\hat{q}$ is carried out and related via dispersion relations to the expectation of local operators. These local operators are then evaluated in quenched SU(2) lattice gauge theory.

  14. Multi-jet Cross Sections at NLO with BlackHat and Sherpa

    Energy Technology Data Exchange (ETDEWEB)

    Berger, C.F.; Bern, Z.; Dixon, L.J.; Cordero, F.Febres; Forde, D.; Gleisberg, T.; Ita, H.; Kosower, D.A.; Maitre, D.

    2009-05-20

    In this talk, we report on a recent next-to-leading order QCD calculation of the production of a W boson in association with three jets at hadron colliders. The computation is performed by combining two programs, BlackHat for the computation of the virtual one-loop matrix elements and Sherpa for the real emission part. The addition of NLO corrections greatly reduces the factorization and renormalization scale dependence of the theory prediction for this process. This result demonstrates the applicability of unitarity-based methods for hadron collider physics.

  15. On Application of the 3-Cornered Hat Technique to Radio Source Position Catalogs

    Science.gov (United States)

    Malkin, Z.

    2013-08-01

    So called ``3-cornered hat'' method (3CH) was originally developed for estimation of the stability of frequency standards (Gray1974). It was then applied for investigation of the noise level of various data, in particular, astronomical and geodetic time series and radio source position catalogs. However, despite this method is widely used, its application is not straightforward because it requires a reliable estimate of the correlations between series under investigation. Neglecting correlations often produces unacceptable results, like negative variances. In this work, we investigate a new possibility to estimate correlations between radio source position catalogs (RSC) obtained from VLBI observations.

  16. Mexican hat curve for hydrogen and antihydrogen-states in natural atom H

    CERN Document Server

    Van Hooydonk, G

    2004-01-01

    Molecular band spectra as well as atomic line spectra reveal a left-right symmetry for atoms (Van Hooydonk, Spectrochim. Acta A, 2000, 56, 2273 and CERN-Ext-2002-041). We now extract a Mexican hat shaped or double well curve from the line spectrum (Lyman ns1/2 singlets) of natural atom H. An H CSB theory and its oscillator contribution (1-0.5pi/n)esp2/nexp2 lead to unprecedented results for antihydrogen physics, ahead of the CERN AD-project on artificial antihydrogen.

  17. The TopHat experiment: A balloon-borne instrument for mapping millimeter and submillimeter emission

    DEFF Research Database (Denmark)

    Silverberg, R.F.; Cheng, E.S.; Aguirre, J.E.;

    2005-01-01

    The TopHat experiment was designed to measure the anisotropy in the cosmic microwave background radiation on angular scales from 0.degrees 3 to 30 degrees and the thermal emission from both Galactic and extragalactic dust. The balloon-borne instrument had five spectral bands spanning frequencies...... from 175 to 630 GHz. The telescope was a compact, 1 m, on-axis Cassegrain telescope designed to scan the sky at a fixed elevation of 78 degrees. The radiometer used cryogenic bolometers coupled to a single feed horn via a dichroic filter system. The observing strategy was intended to efficiently cover...

  18. Inhibition of different histone acetyltransferases (HATs) uncovers transcription-dependent and -independent acetylation-mediated mechanisms in memory formation.

    Science.gov (United States)

    Merschbaecher, Katja; Hatko, Lucyna; Folz, Jennifer; Mueller, Uli

    2016-02-01

    Acetylation of histones changes the efficiency of the transcription processes and thus contributes to the formation of long-term memory (LTM). In our comparative study, we used two inhibitors to characterize the contribution of different histone acetyl transferases (HATs) to appetitive associative learning in the honeybee. For one we applied garcinol, an inhibitor of the HATs of the p300 (EP300 binding protein)/CBP (CREB-binding protein) family, and the HATs of the PCAF (p300/CBP-associated factor) family. As comparative agent we applied C646, a specific inhibitor that selectively blocks HATS of the p300/CBP family. Immunochemical analysis reveals differences in histone H3 acetylation in the honeybee brain, in response to the injection of either C646 or garcinol. Behavioral assessment reveals that the two drugs cause memory impairment of different nature when injected after associative conditioning: processes disturbed by garcinol are annihilated by the established transcription blocker actinomycin D and thus seem to require transcription processes. Actions of C646 are unaltered by actinomycin D, and thus seem to be independent of transcription. The outcome of our different approaches as summarized suggests that distinct HATs contribute to different acetylation-mediated processes in memory formation. We further deduce that the acetylation-mediated processes in memory formation comprise transcription-dependent and transcription-independent mechanisms.

  19. Implications of the Secondary Eclipse of Exoplanet HAT-P-11b

    Science.gov (United States)

    Barry, Richard K.; Deming, L. D.; Bakos, G.; Harrington, J.; Madhusudhan, N.; Noyes, R.; Seager, S.

    2010-01-01

    We observed exoplanet HAT-P-11b and have successfully detected its secondary eclipse. We conducted observations using the Spitzer Space Telescope in the post-cryo mission at 3.6 microns for a period of 22 hours centered on the anticipated secondary eclipse time, to detect the eclipse and determine its phase. Having detected the secondary eclipse, we are at present making a more focused series of observations in both the 3.6 and 4.5 micron bands to fully characterize it. HAT-P-11b is one of only two known exo-Neptunes and has a period of 4.8878 days, radius of 0.422 RJ, mass of 0.081 MJ and semi-major axis 0.053 AU. Measurements of the secondary eclipse will serve to clarify two key issues; 1) the planetary brightness temperature and the nature of its atmosphere, and 2) the eccentricity of its orbit, with implications for its dynamical evolution. We discuss implications of these observations.

  20. A Bayesian analysis of HAT-P-7b using the EXONEST algorithm

    Energy Technology Data Exchange (ETDEWEB)

    Placek, Ben [Department of Physics, University at Albany (SUNY), Albany NY (United States); Knuth, Kevin H. [Department of Physics, University at Albany (SUNY), Albany NY, USA and Department of Informatics, University at Albany (SUNY), Albany NY (United States)

    2015-01-13

    The study of exoplanets (planets orbiting other stars) is revolutionizing the way we view our universe. High-precision photometric data provided by the Kepler Space Telescope (Kepler) enables not only the detection of such planets, but also their characterization. This presents a unique opportunity to apply Bayesian methods to better characterize the multitude of previously confirmed exoplanets. This paper focuses on applying the EXONEST algorithm to characterize the transiting short-period-hot-Jupiter, HAT-P-7b (also referred to as Kepler-2b). EXONEST evaluates a suite of exoplanet photometric models by applying Bayesian Model Selection, which is implemented with the MultiNest algorithm. These models take into account planetary effects, such as reflected light and thermal emissions, as well as the effect of the planetary motion on the host star, such as Doppler beaming, or boosting, of light from the reflex motion of the host star, and photometric variations due to the planet-induced ellipsoidal shape of the host star. By calculating model evidences, one can determine which model best describes the observed data, thus identifying which effects dominate the planetary system. Presented are parameter estimates and model evidences for HAT-P-7b.

  1. Orbital Phase Variations of the Eccentric Giant Planet HAT-P-2b

    CERN Document Server

    Lewis, Nikole K; Showman, Adam P; Cowan, Nicolas B; Laughlin, Gregory; Burrows, Adam; Deming, Drake; Crepp, Justin R; Mighell, Kenneth J; Agol, Eric; Bakos, Gáspár Á; Charbonneau, David; Désert, Jean-Michel; Fischer, Debra A; Fortney, Jonathan J; Hartman, Joel D; Hinkley, Sasha; Howard, Andrew W; Johnson, John Asher; Kao, Melodie; Langton, Jonathan; Marcy, Geoffrey W; Winn, Joshua N

    2013-01-01

    We present the first secondary eclipse and phase curve observations for the highly eccentric hot Jupiter HAT-P-2b in the 3.6, 4.5, 5.8, and 8.0 \\mu m bands of the Spitzer Space Telescope. The 3.6 and 4.5 \\mu m data sets span an entire orbital period of HAT-P-2b, making them the longest continuous phase curve observations obtained to date and the first full-orbit observations of a planet with an eccentricity exceeding 0.2. We present an improved non-parametric method for removing the intrapixel sensitivity variations in Spitzer data at 3.6 and 4.5 \\mu m that robustly maps position-dependent flux variations. We find that the peak in planetary flux occurs at 4.39+/-0.28, 5.84+/-0.39, and 4.68+/-0.37 hours after periapse passage with corresponding maxima in the planet/star flux ratio of 0.1138%+/-0.0089%, 0.1162%+/-0.0080%, and 0.1888%+/-0.0072% in the 3.6, 4.5, and 8.0 \\mu m bands respectively. We compare our measured secondary eclipse depths to the predictions from a one-dimensional radiative transfer model, wh...

  2. The refined physical properties of transiting exoplanetary system WASP-11/HAT-P-10

    International Nuclear Information System (INIS)

    The transiting exoplanetary system WASP-11/HAT-P-10 was observed using the CCD camera at Yunnan Observatories, China from 2008 to 2011, and four new transit light curves were obtained. Combined with published radial velocity measurements, the new transit light curves are analyzed along with available photometric data from the literature using the Markov Chain Monte Carlo technique, and the refined physical parameters of the system are derived, which are compatible with the results of two discovery groups, respectively. The planet mass is Mp = 0.526 ± 0.019 MJ , which is the same as West et al.'s value, and more accurately, the planet radius Rp = 0.999−0.018+0.029 RJ is identical to the value of Bakos et al. The new result confirms that the planet orbit is circular. By collecting 19 available mid-transit epochs with higher precision, we make an orbital period analysis for WASP-11b/HAT-P-10b, and derive a new value for its orbital period, P = 3.72247669 days. Through an (O – C) study based on these mid-transit epochs, no obvious transit timing variation signal can be found for this system during 2008-2012.

  3. The nature of the Napoleon's Hat nebula of SN 1987A

    Science.gov (United States)

    Wang, L.; Dyson, J. E.; Kahn, F. D.

    1993-03-01

    The interstellar and circumstellar environment of SN 1987A is modeled. The geometries of Napoleon's Hat nebula and the dark bay suggest that there is relative motion between the SN progenitor and the surrounding ISM. Most of the dark bay can be identified with the bubble produced by the fast blue supergiant (BSG) wind before the red supergiant (RSG) stage. The relative motion between the star and the ISM is the primary reason for the star being at the edge of this bubble. After the first BSG stage, the star evolves to the RSG stage; the wind velocity is now typically 10 km/s and the mass loss rate is around 10 exp -5 solar mass/yr. The star eventually breaks through the bubble produced in the early BSG stage and starts to interact directly with the ISM outside, thus producing Napoleon's Hat. The success of this model is convincing proof of the BSG-RSG-BSG evolutionary model for the SN 1987A progenitors, and shows that is has moved from the site where it was formed.

  4. Magic hat economics: counter-cultural ideals and practices of the Nordic Ting community

    Directory of Open Access Journals (Sweden)

    Janne Juhana Rantala

    2009-01-01

    Full Text Available The author's anthropological study concerns one of today’s communities with no shared belief system, but with a clear spiritualist orientation. The Nordic Ting Community does not have any defined or committing roles, specialized distribution of tasks, entrance fee to their two annual gatherings, membership or any formal hierarchy. This exiguity of structural differentiation could well be understood to represent ‘subjective spirituality’. This thesis refers to the decline of institutional forms of religion with, instead, an increase in subjective experience in spirituality. This presentation shows that at least in the author's field of study, there hardly exists any increase in emphasis on individualism in spirituality. Instead the material indicates a relatively long continuum of a self-organized type of communality which could be understood as neither individualistic nor collectivistic. The type of agency observed in the social action of the studied network-like field is intersubjective. This article focuses on the use of the magic hat and the combination of ideals and practices characteristic to the Ting Community, which the author calls the magic hat economics. It is argued that by looking at these kinds of intermediating objects, the problem of individualization can be seen much more clearly

  5. The refined physical properties of transiting exoplanetary system WASP-11/HAT-P-10

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Xiao-bin; Gu, Sheng-hong; Wang, Yi-bo [Yunnan Observatories, Chinese Academy of Sciences, Kunming 650011 (China); Cameron, Andrew Collier [School of Physics and Astronomy, University of St Andrews, North Haugh, St Andrews, Fife KY16 9SS (United Kingdom); Hui, Ho-Keung; Kwok, Chi-Tai [Hokoon Nature Education Cum Astronomical Centre, Sik Sik Yuen, Hong Kong (China); Yeung, Bill; Leung, Kam-Cheung, E-mail: shenghonggu@ynao.ac.cn [Hong Kong Astronomical Society, Hong Kong (China)

    2014-04-01

    The transiting exoplanetary system WASP-11/HAT-P-10 was observed using the CCD camera at Yunnan Observatories, China from 2008 to 2011, and four new transit light curves were obtained. Combined with published radial velocity measurements, the new transit light curves are analyzed along with available photometric data from the literature using the Markov Chain Monte Carlo technique, and the refined physical parameters of the system are derived, which are compatible with the results of two discovery groups, respectively. The planet mass is M{sub p} = 0.526 ± 0.019 M{sub J} , which is the same as West et al.'s value, and more accurately, the planet radius R{sub p} = 0.999{sub −0.018}{sup +0.029} R{sub J} is identical to the value of Bakos et al. The new result confirms that the planet orbit is circular. By collecting 19 available mid-transit epochs with higher precision, we make an orbital period analysis for WASP-11b/HAT-P-10b, and derive a new value for its orbital period, P = 3.72247669 days. Through an (O – C) study based on these mid-transit epochs, no obvious transit timing variation signal can be found for this system during 2008-2012.

  6. HATS-3b: An inflated hot Jupiter transiting an F-type star

    CERN Document Server

    Bayliss, D; Penev, K; Bakos, G; Hartman, J; Jordán, A; Mancini, L; Mohler, M; Suc, V; Rabus, M; Béky, B; Csubry, Z; Buchhave, L; Henning, T; Nikolov, N; Csák, B; Brahm, R; Espinoza, N; Noyes, R; Schmidt, B; Conroy, P; Wright, D; Tinney, C; Addison, B; Sackett, P; Sasselov, D; Lázár, J; Papp, I; Sári, P

    2013-01-01

    We report the discovery by the HATSouth survey of HATS-3b, a transiting extrasolar planet orbiting a V=12.4 F-dwarf star. HATS-3b has a period of P = 3.5479d, mass of Mp = 1.07MJ, and radius of Rp = 1.38RJ. Given the radius of the planet, the brightness of the host star, and the stellar rotational velocity (vsini = 9.0km/s), this system will make an interesting target for future observations to measure the Rossiter-McLaughlin effect and determine its spin-orbit alignment. We detail the low/medium-resolution reconnaissance spectroscopy that we are now using to deal with large numbers of transiting planet candidates produced by the HATSouth survey. We show that this important step in discovering planets produces logg and Teff parameters at a precision suitable for efficient candidate vetting, as well as efficiently identifying stellar mass eclipsing binaries with radial velocity semi-amplitudes as low as 1 km/s.

  7. Transmission spectroscopy of the inflated exo-Saturn HAT-P-19b

    CERN Document Server

    Mallonn, M; Weingrill, J; Strassmeier, K G; Ribas, I; Carroll, T A; Herrero, E; Granzer, T; Claret, A; Schwope, A

    2015-01-01

    We observed the Saturn-mass and Jupiter-sized exoplanet HAT-P-19b to refine its transit parameters and ephemeris as well as to shed first light on its transmission spectrum. We monitored the host star over one year to quantify its flux variability and to correct the transmission spectrum for a slope caused by starspots. A transit of HAT-P-19b was observed spectroscopically with OSIRIS at the Gran Telescopio Canarias in January 2012. The spectra of the target and the comparison star covered the wavelength range from 5600 to 7600 AA. One high-precision differential light curve was created by integrating the entire spectral flux. This white-light curve was used to derive absolute transit parameters. Furthermore, a set of light curves over wavelength was formed by a flux integration in 41 wavelength channels of 50 AA width. We analyzed these spectral light curves for chromatic variations of transit depth. The transit fit of the combined white-light curve yields a refined value of the planet-to-star radius ratio o...

  8. Evidence for Water in the Atmosphere of HAT-P-26b Using LDSS-3C

    CERN Document Server

    Stevenson, Kevin B; Seifahrt, Andreas; Gilbert, Greg; Line, Michael R; Desert, Jean-Michel; Fortney, Jonathan J

    2015-01-01

    The characterization of a physically-diverse set of transiting exoplanets is an important and necessary step towards establishing the physical properties linked to the production of obscuring clouds or hazes. Only planets with identifiable spectroscopic features can effectively enhance our understanding of atmospheric chemistry and metallicity. Using data acquired by the newly-commissioned LDSS-3C instrument on Magellan and the Spitzer Space Telescope, we find evidence for water in the transmission spectrum of the Neptune-mass planet HAT-P-26b. Surprisingly, we detect no trace of potassium. Our measured spectrum is best explained by either a high-metallicity, cloud-free atmosphere or a solar-metallicity atmosphere with a cloud deck at ~10 mbar. The presence of strong spectral features in our data suggests that future observations at higher precision could break this degeneracy and reveal the planet's atmospheric composition. We also update HAT-P-26b's transit ephemeris, t_0 = 2455304.65218(25) BJD_TDB, and or...

  9. Structural Performance of a Compressively Loaded Foam-Core Hat-Stiffened Textile Composite Panel

    Science.gov (United States)

    Ambur, Damodar R.; Dexter, Benson H.

    1996-01-01

    A structurally efficient hat-stiffened panel concept that utilizes a structural foam as a stiffener core material has been designed and developed for aircraft primary structural applications. This stiffener concept is fabricated from textile composite material forms with a resin transfer molding process. This foam-filled hat-stiffener concept is structurally more efficient than most other prismatically stiffened panel configurations in a load range that is typical for both fuselage and wing structures. The panel design is based on woven/stitched and braided graphite-fiber textile preforms, an epoxy resin system, and Rohacell foam core. The structural response of this panel design was evaluated for its buckling and postbuckling behavior with and without low-speed impact damage. The results from single-stiffener and multi-stiffener specimen tests suggest that this structural concept responds to loading as anticipated and has excellent damage tolerance characteristics compared to a similar panel design made from preimpregnated graphite-epoxy tape material.

  10. Hat die „ökonomische Theorie der Indexzahlen“ einen Nutzen für die Praxis der Preisstatistik?

    OpenAIRE

    von der Lippe, Peter

    2004-01-01

    Die mit dem Thema gestellte Frage wird sehr unterschiedlich beantwortet. Sie ist vielleicht sogar von bleibender Aktualität, selbst dann, wenn sich die anfängliche Begeisterung für den im Folgenden dargestellten „ökonomischen“ oder COLI-Ansatz abgekühlt haben sollte. Die Begeisterung ist vor allem von der sog. „Boskin Kommission“ in den USA geschürt worden und hat, zumindest was das theoretische Leitbild betrifft, auch das BLS erfasst. Es hat jedoch auch stets kritische Stimmen gegeben, und w...

  11. Chaos in classical string dynamics in $\\hat{\\gamma}$ deformed $AdS_5 \\times T^{1,1}$

    CERN Document Server

    Panigrahi, Kamal L

    2016-01-01

    We consider a circular string in $\\hat{\\gamma}$ deformed $AdS_5 \\times T^{1,1}$ which is localized in the center of $AdS_5$ and winds around the two circles of deformed $T^{1,1}$. We observe chaos in the phase space of the circular string implying non-integrability of string dynamics. The chaotic behaviour in phase space is controlled by energy as well as the deforming parameter $\\hat{\\gamma}$. We further show that the point like object exhibits non-chaotic behaviour. Finally we calculate the Lyapunov exponent for both extended and point like object in support of our first result.

  12. TCUP: A Novel hAT Transposon Active in Maize Tissue Culture

    OpenAIRE

    Smith, Alan M; Hansey, Candice N; Kaeppler, Shawn M.

    2012-01-01

    Transposable elements (TEs) are capable of inducing heritable de novo genetic variation. The sequences capable of reactivation, and environmental factors that induce mobilization, remain poorly defined even in well-studied genomes such as maize. We treated maize tissue culture with the demethylating agent 5-aza-2-deoxcytidine and examined long-term tissue culture lines to discover silenced TEs that have the potential to induce heritable genetic variation. Through these screens we have identif...

  13. Next-to-Leading Order Jet Physics with BlackHat

    CERN Document Server

    Berger, C F; Dixon, L J; Cordero, F Febres; Forde, D; Gleisberg, T; Ita, H; Kosower, D A; Maitre, D

    2009-01-01

    We present several results obtained using the BlackHat next-to-leading order QCD program library, in conjunction with SHERPA. In particular, we present distributions for vector boson plus 1,2,3-jet production at the Tevatron and at the asymptotic running energy of the Large Hadron Collider, including new Z+3-jet distributions. The Z+2-jet predictions for the second-jet P_T distribution are compared to CDF data. We present the jet-emission probability at NLO in W+2-jet events at the LHC, where the tagging jets are taken to be the ones furthest apart in pseudorapidity. We analyze further the large left-handed W polarization, identified in our previous study, for W bosons produced at high P_T at the LHC.

  14. Automatic nuclear bud detection using ellipse fitting, moving sticks or top-hat transformation.

    Science.gov (United States)

    Zhang, C; Sun, C; Vallotton, P; Fenech, M; Pham, T D

    2013-11-01

    Micronucleus assays are extensively used by biologists to assess genotoxicity and to monitor human exposure to genotoxic materials. As recent studies suggested that nuclear buds can be a new source of micronuclei formed in interphase, the quantification of nuclear buds, which are micronucleus like objects that are attached to the nuclei in interphase, in normal and control group is needed. Three automatic nuclear bud detection algorithms fit for different situations are proposed in this paper. One is based on ellipse fitting, one is based on a stick model and the other is based on the top-hat transform. Comparison of the three methods is also given in this paper. Experimental results showed that the proposed algorithms are all effective and efficient for nuclear bud detection. PMID:23961938

  15. Viscous Chaplygin Gas Models as a Spherical Top-Hat Collapsing Fluids

    CERN Document Server

    Jawad, Abdul

    2016-01-01

    We study the spherical top-hat collapse in Einstein gravity and loop quantum cosmology by taking the non-linear evolution of viscous modified variable chaplygin gas and viscous generalized cosmic chaplygin gas. We calculate the equation of state parameter, square speed of sound, perturbed equation of state parameter, perturbed square speed of sound, density contrast and divergence of peculiar velocity in perturbed region and discussed their behavior. It is observed that both chaplygin gas models support the spherical collapse in Einstein as well as loop quantum cosmology because density contrast remains positive in both cases and the perturbed equation of state parameter remains positive at the present epoch as well as near future. It is remarked here that these parameters provide the consistence results for both chaplygin gas models in both gravities.

  16. Spherical top-hat collapse of a viscous unified dark fluid

    Energy Technology Data Exchange (ETDEWEB)

    Li, Wei [Bohai University, Department of Physics, Jinzhou (China); Dalian University of Technology, Institute of Theoretical Physics, Dalian (China); Xu, Lixin [Dalian University of Technology, Institute of Theoretical Physics, Dalian (China)

    2014-05-15

    In this paper, we test the spherical collapse of a viscous unified dark fluid (VUDF) which has constant adiabatic sound speed and show the nonlinear collapse for VUDF, baryons, and darkmatter, which are important in forming the large-scale structure of our Universe. By varying the values of the model parameters α and ζ{sub 0}, we discuss their effects on the nonlinear collapse of the VUDF model, and we compare its result to the ΛCDM model. The results of the analysis show that, within the spherical top-hat collapse framework, larger values of α and smaller values of ζ{sub 0} make the structure formation earlier and faster, and the other collapse curves are almost distinguished with the curve of ΛCDM model if the bulk viscosity coefficient ζ{sub 0} is less than 10{sup -3}. (orig.)

  17. Wave turbulence description of interacting particles: Klein-Gordon model with a Mexican-hat potential

    CERN Document Server

    Gallet, Basile; Dubrulle, Bérengère

    2015-01-01

    In field theory, particles are waves or excitations that propagate on the fundamental state. In experiments or cosmological models one typically wants to compute the out-of-equilibrium evolution of a given initial distribution of such waves. Wave Turbulence deals with out-of-equilibrium ensembles of weakly nonlinear waves, and is therefore well-suited to address this problem. As an example, we consider the complex Klein-Gordon equation with a Mexican-hat potential. This simple equation displays two kinds of excitations around the fundamental state: massive particles and massless Goldstone bosons. The former are waves with a nonzero frequency for vanishing wavenumber, whereas the latter obey an acoustic dispersion relation. Using wave turbulence theory, we derive wave kinetic equations that govern the coupled evolution of the spectra of massive and massless waves. We first consider the thermodynamic solutions to these equations and study the wave condensation transition, which is the classical equivalent of Bo...

  18. Self-assembled ordered structures in thin films of HAT5 discotic liquid crystal

    Directory of Open Access Journals (Sweden)

    Piero Morales

    2010-05-01

    Full Text Available Thin films of the discotic liquid crystal hexapentyloxytriphenylene (HAT5, prepared from solution via casting or spin-coating, were investigated by atomic force microscopy and polarizing optical microscopy, revealing large-scale ordered structures substantially different from those typically observed in standard samples of the same material. Thin and very long fibrils of planar-aligned liquid crystal were found, possibly formed as a result of an intermediate lyotropic nematic state arising during the solvent evaporation process. Moreover, in sufficiently thin films the crystallization seems to be suppressed, extending the uniform order of the liquid crystal phase down to room temperature. This should be compared to the bulk situation, where the same material crystallizes into a polymorphic structure at 68 °C.

  19. High-harmonic and terahertz wave spectroscopy (HATS) for aligned molecules

    CERN Document Server

    Huang, Yindong; Zhao, Jing; Wang, Xiaowei; Lü, Zhihui; Zhang, Dongwen; Yuan, Jianmin; Zhao, Zengxiu

    2016-01-01

    We present the experimental and theoretical details of our recent published letter [Phys. Rev. Lett. 115. 123002] on synchronized high-harmonic and terahertz-wave spectroscopy (HATS) from nonadiabatically aligned nitrogen molecules in dual-color laser fields. Associating the alignment-angle dependent terahertz wave generation with the synchronizing high-harmonic signal, the angular differential photoionization cross section (PICS) for molecules can be reconstructed, and the minima of the angle on PICS show great convergence between the theoretical predictions and the experimental deduced results. We also show the optimal relative phase between the dual-color laser fields for terahertz wave generation dose not change with the alignment angle at a precision of $50$ attoseconds. This all-optical method provides an alternative for investigating molecular structures and dynamics.

  20. "It's your badge of inclusion": the Red Hat Society as a gendered subculture of aging.

    Science.gov (United States)

    Barrett, Anne E; Pai, Manacy; Redmond, Rebecca

    2012-12-01

    Although studies document the health-enhancing effects of social engagement, they reveal little about the underlying mechanisms operating within specific organizational contexts. Limited attention is given to the role of inequality--particularly age and gender--in shaping either the organizations to which we belong or their consequences for our well-being. We address this issue by examining the Red Hat Society, a social organization for middle-aged and older women. Interviews with members (n=52) illustrate how age and gender inequality interact to shape the organization, which can be viewed as a gendered subculture of aging. Drawing on this framework, we discuss four processes through which participation generates benefits for older women involved in age- and gender-segregated organizations: enhancing social networks, countering invisibility, creating positive frames for aging experiences, and promoting youthful identities.

  1. Viscous Chaplygin gas models as spherical top-hat collapsing fluids

    Science.gov (United States)

    Jawad, Abdul; Iqbal, Ayesha

    2016-05-01

    We study the spherical top-hat collapse in Einstein gravity and loop quantum cosmology (LQC) by taking the nonlinear evolution of viscous modified variable Chaplygin gas (CG) and viscous generalized cosmic chaplygin gas (GCCG). We calculate the equation of state (EoS) parameter, square speed of sound, perturbed (EoS) parameter, perturbed square speed of sound, density contrast and divergence of peculiar velocity in perturbed region and discussed their behavior. It is observed that both CG models support the spherical collapse (SC) in Einstein as well as LQC because density contrast remains positive in both cases and the perturbed EoS parameter remains positive at the present epoch as well as near future. It is remarked here that these parameters provide consistent results for both CG models in both gravities.

  2. HAT-P-55b: A Hot Jupiter Transiting a Sun-like Star

    CERN Document Server

    Juncher, D; Hartman, J D; Bakos, G Á; Bieryla, A; Kovács, T; Boisse, I; Latham, D W; Kovács, G; Bhatti, W; Csubry, Z; Penev, K; de Val-Borro, M; Falco, E; Torres, G; Noyes, R W; Lázár, J; Papp, I; Sári, P

    2015-01-01

    We report the discovery of a new transiting extrasolar planet, HAT-P-55b. The planet orbits a V = 13.207 +/- 0.039 sun-like star with a mass of 1.013 +/- 0.037 solar masses, a radius of 1.011 +/- 0.036 solar radii and a metallicity of -0.03 +/- 0.08. The planet itself is a typical hot Jupiter with a period of 3.5852467 +/- 0.0000064 days, a mass of 0.582 +/- 0.056 Jupiter masses and a radius of 1.182 +/- 0.055 Jupiter radii. This discovery adds to the increasing sample of transiting planets with measured bulk densities, which is needed to put constraints on models of planetary structure and formation theories.

  3. Using Edward de Bono's six hats game to aid critical thinking and reflection in palliative care.

    Science.gov (United States)

    Kenny, Lesley J

    2003-03-01

    This article describes the use of a creative thinking game to stimulate critical thinking and reflection with qualified health professionals undertaking palliative care education. The importance of reflective practice in nursing is well documented and numerous models are available. However, the author as a nurse teacher has found that many of these models are either too simple or too complex to be valuable in practice. The six hats game, devised by Edward de Bono, is a method that stimulates a variety of types of thinking and when used as a means of reflection helps students to become more critical about their practice. Using this game with a palliative care case study the author demonstrates how thinking more creatively about the patients' perceived needs and problems can assist in developing reflective skills. The article concludes with a discussion on some of the challenges of using this method and suggestions for future practical uses.

  4. Development of a helmet/helmet-display-unit alignment tool (HAT) for the Apache helmet and display unit

    Science.gov (United States)

    McLean, William; Statz, Jonathan; Estes, Victor; Booms, Shawn; Martin, John S.; Harding, Thomas

    2015-05-01

    Project Manager (PM) Apache Block III contacted the U.S. Army Aeromedical Research Laboratory (USAARL), Fort Rucker, Alabama, requesting assistance to evaluate and find solutions to a government-developed Helmet Display Unit (HDU) device called the Mock HDU for helmet alignment of the Apache Advanced Integrated Helmet (AAIH). The AAIH is a modified Head Gear Unit No. 56 for Personnel (HGU-56/P) to replace the current Integrated Helmet and Sighting System (IHADSS). The current flashlight-based HDU simulator for helmet/HDU alignment was no longer in production or available. Proper helmet/HDU alignment is critical to position the right eye in the small HDU eye box to obtain image alignment and full field of view (FOV). The initial approach of the PM to developing a helmet/HDU fitting device (Mock HDU) was to duplicate the optical characteristics of the current tactical HDU using less complex optics. However, the results produced questionable alignment, FOV, and distortion issues, with cost and development time overruns. After evaluating the Mock HDU, USAARL proposed a cost effective, less complex optical design called the Helmet/HDU Alignment Tool (HAT). This paper will show the development, components, and evaluations of the HAT compared to the current flashlight HDU simulator device. The laboratory evaluations included FOV measurements and alignment accuracies compared to tactical HDUs. The Apache helmet fitter technicians and Apache pilots compared the HAT to the current flashlight based HDU and ranked the HAT superior.

  5. BALTIMORE’S M.S. LEVY AND SONS: Straw Hat Makers to the World, 1870-1960

    Directory of Open Access Journals (Sweden)

    Jessica I. Elfenbein

    2008-01-01

    Full Text Available From 1860 to 1960, Baltimore was an important center of the men’s ready-to- wear clothing industries. German-speaking Jews created many businesses that manufactured and sold underwear, men’s suits, and specialty items like hats and umbrellas. The straw hat making firm started by M.S. Levy is an interesting example of a Baltimore-based, family-owned niche business that existedfor 90 years, through three generations ofa singlefamily. The M.S. Levy and Sons story has two main chapters. The first covers the period from its founding by Michael Simon Levy in the 1870s through his son Julius’ death in 1926. This is the story of ascension. A premonition about the coming popularity of straw hats, together with a small but important technological breakthrough, positioned a family and a small industry for significant expansion. The second period began in 1930 with the introduction of wool felt hats and the death of William, M.S. Levy’s oldest son, and includes the Great Depression, unionization, merger, third generation leadership, and finally, in 1959, the family’s withdrawal from the industry. This later period, as told by grandsons of the founder, is the story of struggle followed by decline.

  6. Partition functions of 3d $\\hat D$-quivers and their mirror duals from 1d free fermions

    CERN Document Server

    Assel, Benjamin; Felix, Jan

    2015-01-01

    We study the matrix models calculating the sphere partition functions of 3d gauge theories with $\\mathcal{N}=4$ supersymmetry and a quiver structure of a $\\hat D$ Dynkin diagram (where each node is a unitary gauge group). As in the case of necklace ($\\hat A $) quivers, we can map the problem to that of free fermion quantum mechanics whose complicated Hamiltonian we find explicitly. Many of these theories are conjectured to be dual under mirror symmetry to certain unitary linear quivers with extra Sp nodes or antisymmetric hypermultiplets. We show that the free fermion formulations of such mirror pairs are related by a linear symplectic transformation. We then study the large N expansion of the partition function, which as in the case of the $\\hat A$-quivers is given to all orders in 1/N by an Airy function. We simplify the algorithm to calculate the numerical coefficients appearing in the Airy function and evaluate them for a wide class of $\\hat D$-quiver theories.

  7. Inhibition of Different Histone Acetyltransferases (HATs) Uncovers Transcription-Dependent and -Independent Acetylation-Mediated Mechanisms in Memory Formation

    Science.gov (United States)

    Merschbaecher, Katja; Hatko, Lucyna; Folz, Jennifer; Mueller, Uli

    2016-01-01

    Acetylation of histones changes the efficiency of the transcription processes and thus contributes to the formation of long-term memory (LTM). In our comparative study, we used two inhibitors to characterize the contribution of different histone acetyl transferases (HATs) to appetitive associative learning in the honeybee. For one we applied…

  8. SPITZER IRAC SECONDARY ECLIPSE PHOTOMETRY OF THE TRANSITING EXTRASOLAR PLANET HAT-P-1b

    International Nuclear Information System (INIS)

    We report Spitzer/IRAC photometry of the transiting giant exoplanet HAT-P-1b during its secondary eclipse. This planet lies near the postulated boundary between the pM and pL-class of hot Jupiters, and is important as a test of models for temperature inversions in hot Jupiter atmospheres. We derive eclipse depths for HAT-P-1b, in units of the stellar flux, that are: 0.080% ± 0.008% [3.6 μm], 0.135% ± 0.022% [4.5 μm], 0.203% ± 0.031% [5.8 μm], and 0.238% ± 0.040% [8.0 μm]. These values are best fit using an atmosphere with a modest temperature inversion, intermediate between the archetype inverted atmosphere (HD 209458b) and a model without an inversion. The observations also suggest that this planet is radiating a large fraction of the available stellar irradiance on its dayside, with little available for redistribution by circulation. This planet has sometimes been speculated to be inflated by tidal dissipation, based on its large radius in discovery observations, and on a non-zero orbital eccentricity allowed by the radial velocity data. The timing of the secondary eclipse is very sensitive to orbital eccentricity, and we find that the central phase of the eclipse is 0.4999 ± 0.0005. The difference between the expected and observed phase indicates that the orbit is close to circular, with a 3σ limit of |e cos ω| < 0.002.

  9. HATS-3b: An Inflated Hot Jupiter Transiting an F-type Star

    Science.gov (United States)

    Bayliss, D.; Zhou, G.; Penev, K.; Bakos, G. Á.; Hartman, J. D.; Jordán, A.; Mancini, L.; Mohler-Fischer, M.; Suc, V.; Rabus, M.; Béky, B.; Csubry, Z.; Buchhave, L.; Henning, T.; Nikolov, N.; Csák, B.; Brahm, R.; Espinoza, N.; Noyes, R. W.; Schmidt, B.; Conroy, P.; Wright, D. J.; Tinney, C. G.; Addison, B. C.; Sackett, P. D.; Sasselov, D. D.; Lázár, J.; Papp, I.; Sári, P.

    2013-11-01

    We report the discovery by the HATSouth survey of HATS-3b, a transiting extrasolar planet orbiting a V = 12.4 F dwarf star. HATS-3b has a period of P = 3.5479 days, mass of Mp = 1.07 M J, and radius of Rp = 1.38 R J. Given the radius of the planet, the brightness of the host star, and the stellar rotational velocity (vsin i = 9.0 km s-1), this system will make an interesting target for future observations to measure the Rossiter-McLaughlin effect and determine its spin-orbit alignment. We detail the low-/medium-resolution reconnaissance spectroscopy that we are now using to deal with large numbers of transiting planet candidates produced by the HATSouth survey. We show that this important step in discovering planets produces log g and T eff parameters at a precision suitable for efficient candidate vetting, as well as efficiently identifying stellar mass eclipsing binaries with radial velocity semi-amplitudes as low as 1 km s-1. The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), and the Australian National University (ANU). The station at Las Campanas Observatory (LCO) of the Carnegie Institute is operated by PU in conjunction with collaborators at the Pontificia Universidad Católica de Chile (PUC), the station at the High Energy Spectroscopic Survey (HESS) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU.

  10. HAT-P-13b,c: A TRANSITING HOT JUPITER WITH A MASSIVE OUTER COMPANION ON AN ECCENTRIC ORBIT

    International Nuclear Information System (INIS)

    We report on the discovery of a planetary system with a close-in transiting hot Jupiter on a near circular orbit and a massive outer planet on a highly eccentric orbit. The inner planet, HAT-P-13b, transits the bright V = 10.622 G4 dwarf star GSC 3416 - 00543 every P = 2.916260 ± 0.000010 days, with transit epoch Tc = 2454779.92979 ± 0.00038 (BJD) and duration 0.1345 ± 0.0017 days. The outer planet HAT-P-13c orbits the star every P 2 = 428.5 ± 3.0 days with a nominal transit center (assuming zero impact parameter) of T 2c = 2454870.4 ± 1.8 (BJD) or time of periastron passage T 2,peri = 2454890.05 ± 0.48 (BJD). Transits of the outer planet have not been observed, and may not be present. The host star has a mass of 1.22+0.05-0.10 M sun, radius of 1.56 ± 0.08 R sun, effective temperature of 5653 ± 90 K, and is rather metal-rich with [Fe/H] = +0.41 ± 0.08. The inner planetary companion has a mass of 0.853+0.029-0.046 M J, and radius of 1.281 ± 0.079 R J, yielding a mean density of 0.498+0.103-0.069 g cm-3. The outer companion has m 2sin i 2 = 15.2 ± 1.0 M J, and orbits on a highly eccentric orbit of e 2 = 0.691 ± 0.018. While we have not detected significant transit timing variations of HAT-P-13b, due to gravitational and light-travel time effects, future observations will constrain the orbital inclination of HAT-P-13c, along with its mutual inclination to HAT-P-13b. The HAT-P-13 (b, c) double-planet system may prove extremely valuable for theoretical studies of the formation and dynamics of planetary systems.

  11. Structure of the Hat Creek graben region: Implications for the structure of the Hat Creek graben and transfer of right-lateral shear from the Walker Lane north of Lassen Peak, northern California, from gravity and magnetic anomalies

    Science.gov (United States)

    Langenheim, Victoria; Jachens, Robert C.; Clynne, Michael A.; Muffler, L. J. Patrick

    2016-01-01

    Interpretation of magnetic and new gravity data provides constraints on the geometry of the Hat Creek Fault, the amount of right-lateral offset in the area between Mt. Shasta and Lassen Peak, and confirmation of the influence of pre-existing structure on Quaternary faulting. Neogene volcanic rocks coincide with short-wavelength magnetic anomalies of both normal and reversed polarity, whereas a markedly smoother magnetic field occurs over the Klamath Mountains and its Paleogene cover. Although the magnetic field over the Neogene volcanic rocks is complex, the Hat Creek Fault, which is one of the most prominent normal faults in the region and forms the eastern margin of the Hat Creek Valley, is marked by the eastern edge of a north-trending magnetic and gravity high 20-30 km long. Modeling of these anomalies indicates that the fault is a steeply dipping (~75-85°) structure. The spatial relationship of the fault as modeled by the potential-field data, the youngest strand of the fault, and relocated seismicity suggests that deformation continues to step westward across the valley, consistent with a component of right-lateral slip in an extensional environment. Filtered aeromagnetic data highlight a concealed magnetic body of Mesozoic or older age north of Hat Creek Valley. The body’s northwest margin strikes northeast and is linear over a distance of ~40 km. Within the resolution of the aeromagnetic data (1-2 km), we discern no right-lateral offset of this body. Furthermore, Quaternary faults change strike or appear to end, as if to avoid this concealed magnetic body and to pass along its southeast edge, suggesting that pre-existing crustal structure influenced younger faulting, as previously proposed based on gravity data.

  12. Broad-band spectrophotometry of HAT-P-32 b: Search for a scattering signature in the planetary spectrum

    CERN Document Server

    Mallonn, M; Herrero, E; Hoyer, S; Kirk, J; Wheatley, P J; Seeliger, M; Mackebrandt, F; von Essen, C; Strassmeier, K G; Granzer, T; Künstler, A; Dhillon, V S; Marsh, T R; Gaitan, J

    2016-01-01

    Multi-colour broad-band transit observations offer the opportunity to characterise the atmosphere of an extrasolar planet with small- to medium-sized telescopes. One of the most favourable targets is the hot Jupiter HAT-P-32 b. We combined 21 new transit observations of this planet with 36 previously published light curves for a homogeneous analysis of the broad-band transmission spectrum from the Sloan u' band to the Sloan z' band. Our results rule out cloud-free planetary atmosphere models of solar metallicity. Furthermore, a discrepancy at reddest wavelengths to previously published results makes a recent tentative detection of a scattering feature less likely. Instead, the available spectral measurements of HAT-P-32 b favour a completely flat spectrum from the near-UV to the near-IR. A plausible interpretation is a thick cloud cover at high altitudes.

  13. Design and evaluation of a foam-filled hat-stiffened panel concept for aircraft primary structural applications

    Science.gov (United States)

    Ambur, Damodar R.

    1995-01-01

    A structurally efficient hat-stiffened panel concept that utilizes a structural foam as stiffener core has been designed for aircraft primary structural applications. This stiffener concept utilizes a manufacturing process that can be adapted readily to grid-stiffened structural configurations which possess inherent damage tolerance characteristics due to their multiplicity of load paths. The foam-filled hat-stiffener concept in a prismatically stiffened panel configuration is more efficient than most other stiffened panel configurations in a load range that is typical for both fuselage and wing structures. The prismatically stiffened panel concept investigated here has been designed using AS4/3502 preimpregnated tape and Rohacell foam core and evaluated for its buckling and postbuckling behavior with and without low-speed impact damage. The results from single-stiffener and multi-stiffener specimens suggest that this structural concept responds to loading as anticipated and has good damage tolerance characteristics.

  14. Detection of DNA Hypomethylation Mediated Floral Induction in Longan and Spinach Using the HAT-RAPD Technique

    Directory of Open Access Journals (Sweden)

    S. Anuntalabhochai

    2009-01-01

    Full Text Available In this study, the HAT-RAPD technique was used to detect DNA methylation in the four plant species, rice (Oryza sativa, petunia (Petunia hybrida, spinach (Spinacea oleracea L. and longan (Dimocarpus longan Lour., which were treated using 5-azacytidine, potassium chlorate (KClO3 and a low temperature induction. Rice and petunia were chosen to be induced because in these species it is known that 5-azacytidine is able to induce hypomethylation in their genomes leading to morphological changes, in particular floral induction, in the developing plants. Using the HAT-RAPD technique, DNA methylation was detected using the restriction enzymes HpaII and MspI in rice and petunia (as expected and in spinach, but was found to be absent in longan, which suggests that floral induction in longan is undetectable in longan.

  15. Improvement and evaluation of polymer-matrix composite panels with hat stiffeners

    Directory of Open Access Journals (Sweden)

    Li S. J.

    2016-01-01

    Full Text Available Hat-stiffened composite panels fabricated by co-curing technologies are widely used in the fuselage panel due to the good structural stability and high efficiency of axial load transferring. The bonding capability between the stiffener and skin is a primary criterion to assess the co-curing quality. In this paper, two reinforcement technologies of filling filler in the triangle region and adding split-stopping tape between the stiffener and skin were employed to improve the bonding capability. Effect of filler and split-stopping tape on the interface strength was analyzed, and the optimal size range of the filler and split-stopping tape were obtained. To improve the universality of application for the two reinforcement techniques, the filling coefficient of 0.62~0.77 and the split-stopping tape width coefficient of 0.56~0.67 were obtained by calculation. Results of the study can be used to develop other kinds of stiffened panels and will ultimately lead to optimized skin/stiffener designs.

  16. Improved hole-transporting property via HAT-CN for perovskite solar cells without lithium salts.

    Science.gov (United States)

    Ma, Yingzhuang; Chung, Yao-Hsien; Zheng, Lingling; Zhang, Danfei; Yu, Xiao; Xiao, Lixin; Chen, Zhijian; Wang, Shufeng; Qu, Bo; Gong, Qihuang; Zou, Dechun

    2015-04-01

    A nonadditive hole-transporting material (HTM) of a triphenylamine derivative of N,N'-di(3-methylphenyl)-N,N'-diphenyl-4,4'-diaminobiphenyl (TPD) is used for the organic-inorganic hybrid perovskite solar cells. The power conversion efficiency (PCE) can be significantly enhanced by inserting a thin layer of 1,4,5,8,9,11-hexaazatriphenylenehexacarbonitrile (HAT-CN) without adding an ion additive because the hole-transporting properties improve. The short-circuit current density (J(sc)) increases from 8.5 to 13.1 mA/cm(2), the open-circuit voltage (V(oc)) increases from 0.84 to 0.92 V, and the fill-factor (FF) increases from 0.45 to 0.59, which corresponds to the increase in PCE from 3.2% to 7.1%. Moreover, the PCE decreases by only 10% after approximately 1000 h without encapsulation, which suggests an alternative method to improve the stability of perovskite solar cells. PMID:25761404

  17. Sampling of BTX in Hat Yai city using cost effective laboratory-built PCB passive sampler.

    Science.gov (United States)

    Subba, Jas Raj; Thammakhet, Chongdee; Thavarungkul, Panote; Kanatharana, Proespichaya

    2016-08-23

    A laboratory-built printed circuit board (PCB) passive sampler used for the monitoring of xylene and styrene in copy print shops was re-validated for detecting benzene, toluene and xylene (BTX) and applied for the sampling of ambient air from Hat Yai city, Songkhla, Thailand, in the month of November 2014. For monitoring, the PCB passive samplers were exposed to target analytes in 16 locations covering high to low exposure areas. After sampling, the samplers were thermally desorbed and the analytes were trapped by multi-walled carbon nanotubes packed into a micro-preconcentrator coupled to a gas chromatograph (GC) equipped with a flame ionization detector. At the optimum GC operating conditions, the linear dynamic ranges for BTX were 0.06-5.6 µg for benzene, 0.07-2.2 µg for toluene and 0.23-2.5 µg for xylene with R(2) > 0.99 with the limits of detection being 6.6, 6.8 and 19 ng for benzene, toluene and xylene, respectively. The concentrations of BTX in the 16 sampling sites were in the range of N.D.-1.3 ± 1.6, 4.50 ± 0.76-49.6 ± 3.7 and 1.00 ± 0.21-39.6 ± 3.1 µg m(-3), respectively. When compared to past studies, there had been an increase in the benzene concentration. PMID:27231039

  18. HAT-P-55b: A Hot Jupiter Transiting a Sun-Like Star

    Science.gov (United States)

    Juncher, D.; Buchhave, L. A.; Hartman, J. D.; Bakos, G. Á.; Bieryla, A.; Kovács, T.; Boisse, I.; Latham, D. W.; Kovács, G.; Bhatti, W.; Csubry, Z.; Penev, K.; de Val-Borro, M.; Falco, E.; Torres, G.; Noyes, R. W.; Lázár, J.; Papp, I.; Sári, P.

    2015-09-01

    We report the discovery of a new transiting extrasolar planet, HAT-P-55b . The planet orbits a V = 13.207 ± 0.039 sun-like star with a mass of 1.013 ± 0.037 Msolar, a radius of 1.011 ± 0.036 Rsolar, and a metallicity of -0.03 ± 0.08. The planet itself is a typical hot Jupiter with a period of 3.5852467 ± 0.0000064 days, a mass of 0.582 ± 0.056 MJ and a radius of 1.182 ± 0.055 RJ. This discovery adds to the increasing sample of transiting planets with measured bulk densities, which is needed to put constraints on models of planetary structure and formation theories. Based on observations obtained with the Hungarian-made Automated Telescope Network. Based in part on radial velocities obtained with the SOPHIE spectrograph mounted on the 1.93-m telescope at Observatoire de Haute-Provence, France. Based in part on observations made with the Nordic Optical Telescope, operated on the island of La Palma jointly by Denmark, Finland, Iceland, Norway, and Sweden, in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias. Based in part on observations obtained with the Tillinghast Reflector 1.5-m telescope and the 1.2-m telescope, both operated by the Smithsonian Astrophysical Observatory at the Fred Lawrence Whipple Observatory in Arizona.

  19. Bayesian estimation inherent in a Mexican-hat-type neural network

    Science.gov (United States)

    Takiyama, Ken

    2016-05-01

    Brain functions, such as perception, motor control and learning, and decision making, have been explained based on a Bayesian framework, i.e., to decrease the effects of noise inherent in the human nervous system or external environment, our brain integrates sensory and a priori information in a Bayesian optimal manner. However, it remains unclear how Bayesian computations are implemented in the brain. Herein, I address this issue by analyzing a Mexican-hat-type neural network, which was used as a model of the visual cortex, motor cortex, and prefrontal cortex. I analytically demonstrate that the dynamics of an order parameter in the model corresponds exactly to a variational inference of a linear Gaussian state-space model, a Bayesian estimation, when the strength of recurrent synaptic connectivity is appropriately stronger than that of an external stimulus, a plausible condition in the brain. This exact correspondence can reveal the relationship between the parameters in the Bayesian estimation and those in the neural network, providing insight for understanding brain functions.

  20. Point Source Detection using the Spherical Mexican Hat Wavelet on simulated all-sky Planck maps

    CERN Document Server

    Vielva, P; Gallegos, J E; Toffolatti, L; Sanz, J L

    2003-01-01

    We present an estimation of the point source (PS) catalogue that could be extracted from the forthcoming ESA Planck mission data. We have applied the Spherical Mexican Hat Wavelet in simulated all-sky maps that include CMB, Galactic emission, thermal Sunyaev-Zel'dovich effect and PS emission, as well as instrumental white noise. We have developed an algorithm focused on a fast optimal scale determination, that is crucial to achieve a PS catologue with a large number of detections and a low flux limit. An important effort has been also done to reduce the CPU time processor for spherical harmonic trans formation, in order to perform the PS detection in a reasonable time. The presented algorithm is able to provide a PS catalogue above fluxes: 1.39 Jy (857 GHz), 0.84 Jy (545 GHz), 0.30 Jy (353 GHz), 0.16 Jy (217 GHz), 0.17 Jy (143 GHz), 0.19 Jy (100 GHz HFI), 0.22 Jy (100 GHz LFI), 0.28 Jy (70 GHz), 0.33 Jy (44 GHz) and 0.37 Jy (30 GHz). We detect around 36700 PS at the highest frequency Planck channel and 2200 a...

  1. Bayesian estimation inherent in a Mexican-hat-type neural network.

    Science.gov (United States)

    Takiyama, Ken

    2016-05-01

    Brain functions, such as perception, motor control and learning, and decision making, have been explained based on a Bayesian framework, i.e., to decrease the effects of noise inherent in the human nervous system or external environment, our brain integrates sensory and a priori information in a Bayesian optimal manner. However, it remains unclear how Bayesian computations are implemented in the brain. Herein, I address this issue by analyzing a Mexican-hat-type neural network, which was used as a model of the visual cortex, motor cortex, and prefrontal cortex. I analytically demonstrate that the dynamics of an order parameter in the model corresponds exactly to a variational inference of a linear Gaussian state-space model, a Bayesian estimation, when the strength of recurrent synaptic connectivity is appropriately stronger than that of an external stimulus, a plausible condition in the brain. This exact correspondence can reveal the relationship between the parameters in the Bayesian estimation and those in the neural network, providing insight for understanding brain functions.

  2. Further constraints on the optical transmission spectrum of HAT-P-1b

    CERN Document Server

    Montalto, M; Santos, N C; Desidera, S; Martins, J H C; Figueira, P; Alonso, R; .,

    2015-01-01

    We report on novel observations of HAT-P-1 aimed at constraining the optical transmission spectrum of the atmosphere of its transiting Hot-Jupiter exoplanet. Ground-based differential spectrophotometry was performed over two transit windows using the DOLORES spectrograph at the Telescopio Nazionale Galileo (TNG). Our measurements imply an average planet to star radius ratio equal to $\\rm R_p/R_{\\star}$=(0.1159$\\pm$0.0005). This result is consistent with the value obtained from recent near infrared measurements of this object but differs from previously reported optical measurements being lower by around 4.4 exoplanet scale heights. Analyzing the data over 5 different spectral bins 600\\AA$\\,$ wide we observed a single peaked spectrum (3.7 $\\rm\\sigma$ level) with a blue cut-off corresponding to the blue edge of the broad absorption wing of sodium and an increased absorption in the region in between 6180-7400\\AA. We also infer that the width of the broad absorption wings due to alkali metals is likely narrower t...

  3. Confrontation of Top-Hat Spherical Collapse against Dark Halos from Cosmological N-Body Simulations

    CERN Document Server

    Suto, Daichi; Osato, Ken; Sasaki, Shin; Suto, Yasushi

    2015-01-01

    The top-hat spherical collapse model (TSC) is one of the most fundamental analytical frameworks to describe the non-linear growth of cosmic structure. TSC has motivated, and been widely applied in, various researches even in the current era of precision cosmology. While numerous studies exist to examine its validity against numerical simulations in a statistical fashion, there are few analyses to compare the TSC dynamics in an individual object-wise basis, which is what we attempt in the present paper. We extract 100 halos at z = 0 from a cosmological N-body simulation according to the conventional TSC criterion for the spherical over-density. Then we trace back their spherical counter-parts at earlier epochs. Just prior to the turn-around epoch of the halos, their dynamics is well approximated by TSC, but their turn-around epochs are systematically delayed and the virial radii are larger by ~ 20 percent on average relative to the TSC predictions. We find that this systematic deviation is mainly ascribed to t...

  4. Intensity and Pattern of Land Surface Temperature in Hat Yai City, Thailand

    Directory of Open Access Journals (Sweden)

    Poonyanuch RUTHIRAKO

    2014-07-01

    Full Text Available Land Surface Temperature (LST is an important factor in global climate. LST is governed by surface heat fluxes, which are affected by urbanization. In order to understand urban climate, LST needs to be examined. This study aimed to investigate the intensity and pattern of LST and examine the relationships between LST and the characteristics of urban land use, indices, and population density in Hat Yai City. Landsat 5TM images were used for interpretation of land use characteristics and derivation of LST, normalized difference built-up index (NDBI and normalized vegetation index (NDVI. The characteristics of land use were classified into 4 types: commercial/high density residential, medium density residential, minimum density residential and vegetation cover/park. The average maximum and minimum LST derived from Landsat 5TM were 25.9, 33.7 and 15.8 °C, respectively. The areas with high LST were located principally in central built-up areas, slightly northwest-southeast of the study area, including the commercial center and the newly expanded residential areas. The LST pattern was well related to land use types and population density. The relationship between LST and NDVI however portrayed negative correlation, while that between LST and NDBI highlighted a positive correlation. It is concluded that NDVI and NDBI can be used to evaluate the risk of Urban Heat Island (UHI and may help city managers better prepare for possible impacts of climate change.

  5. Standard Model evaluation of $\\varepsilon_K$ using lattice QCD inputs for $\\hat{B}_K$ and $V_{cb}$

    CERN Document Server

    Bailey, Jon A; Lee, Weonjong; Park, Sungwoo

    2015-01-01

    We report the Standard Model evaluation of the indirect CP violation parameter $\\varepsilon_K$ using inputs from lattice QCD: the kaon bag parameter $\\hat{B}_K$, $\\xi_0$, $|V_{us}|$ from the $K_{\\ell 3}$ and $K_{\\mu 2}$ decays, and $|V_{cb}|$ from the axial current form factor for the exclusive decay $\\bar{B} \\to D^* \\ell \\bar{\

  6. Energy versus centrality dependence of the jet quenching parameter hat{q} at RHIC and LHC: a new puzzle?

    Science.gov (United States)

    Andrés, Carlota; Armesto, Néstor; Luzum, Matthew; Salgado, Carlos A.; Zurita, Pía

    2016-09-01

    The central goal of jet quenching studies in high-energy nuclear collisions is the characterization of those QCD medium properties that are accessible by these probes. Most of the discussion in the last years has been focused on the determination of the jet quenching parameter, hat{q}. We present here an extraction of this parameter using data of inclusive particle suppression at RHIC and LHC energies for different centralities. Our approach consists in fitting a K factor that quantifies the departure of this parameter from an ideal estimate, K≡ hat{q}/(2ɛ ^{3/4}), where hat{q} is determined by the local medium quantities as provided by hydrodynamical calculations. We find that this K factor is larger at RHIC than at the LHC, as obtained already in previous analyses, but, surprisingly, it is almost independent of the centrality of the collision. Taken at face value, the K factor would not depend on the local properties of the medium as energy density or temperature, but on global collision quantities such as the center of mass energy. This is a very intriguing, unexpected possibility for which we cannot yet provide a clear interpretation. We also comment on the limitations of the formalism that may affect this conclusion.

  7. The GTC exoplanet transit spectroscopy survey. IV. Confirmation of the flat transmission spectrum of HAT-P-32b

    CERN Document Server

    Nortmann, L; Murgas, F; Dreizler, S; Iro, N; Cabrera-Lavers, A

    2016-01-01

    We observed the hot Jupiter HAT-P-32b (also known as HAT-P-32Ab) to determine its optical transmission spectrum by measuring the wavelength-dependent planet-to-star radius ratios in the region between 518 - 918 nm. We used the OSIRIS instrument at the GTC in long slit spectroscopy mode, placing HAT-P-32 and a reference star in the same slit and obtaining a time series of spectra covering two transit events. Using the best quality data set, we were able to yield 20 narrow-band transit light curves, with each passband spanning a 20 nm wide interval. After removal of all systematic noise signals and light curve modeling the uncertainties for the resulting radius ratios lie between 337 and 972 ppm. The radius ratios show little variation with wavelength suggesting a high altitude cloud layer masking any atmospheric features. Alternatively, a strong depletion in alkali metals or a much smaller than expected planetary atmospheric scale height could be responsible for the lack of atmospheric features. Our result of ...

  8. Fluctuations of hi-hat timing and dynamics in a virtuoso drum track of a popular music recording.

    Directory of Open Access Journals (Sweden)

    Esa Räsänen

    Full Text Available Long-range correlated temporal fluctuations in the beats of musical rhythms are an inevitable consequence of human action. According to recent studies, such fluctuations also lead to a favored listening experience. The scaling laws of amplitude variations in rhythms, however, are widely unknown. Here we use highly sensitive onset detection and time series analysis to study the amplitude and temporal fluctuations of Jeff Porcaro's one-handed hi-hat pattern in "I Keep Forgettin'"-one of the most renowned 16th note patterns in modern drumming. We show that fluctuations of hi-hat amplitudes and interbeat intervals (times between hits have clear long-range correlations and short-range anticorrelations separated by a characteristic time scale. In addition, we detect subtle features in Porcaro's drumming such as small drifts in the 16th note pulse and non-trivial periodic two-bar patterns in both hi-hat amplitudes and intervals. Through this investigation we introduce a step towards statistical studies of the 20th and 21st century music recordings in the framework of complex systems. Our analysis has direct applications to the development of drum machines and to drumming pedagogy.

  9. Fluctuations of hi-hat timing and dynamics in a virtuoso drum track of a popular music recording.

    Science.gov (United States)

    Räsänen, Esa; Pulkkinen, Otto; Virtanen, Tuomas; Zollner, Manfred; Hennig, Holger

    2015-01-01

    Long-range correlated temporal fluctuations in the beats of musical rhythms are an inevitable consequence of human action. According to recent studies, such fluctuations also lead to a favored listening experience. The scaling laws of amplitude variations in rhythms, however, are widely unknown. Here we use highly sensitive onset detection and time series analysis to study the amplitude and temporal fluctuations of Jeff Porcaro's one-handed hi-hat pattern in "I Keep Forgettin'"-one of the most renowned 16th note patterns in modern drumming. We show that fluctuations of hi-hat amplitudes and interbeat intervals (times between hits) have clear long-range correlations and short-range anticorrelations separated by a characteristic time scale. In addition, we detect subtle features in Porcaro's drumming such as small drifts in the 16th note pulse and non-trivial periodic two-bar patterns in both hi-hat amplitudes and intervals. Through this investigation we introduce a step towards statistical studies of the 20th and 21st century music recordings in the framework of complex systems. Our analysis has direct applications to the development of drum machines and to drumming pedagogy. PMID:26039256

  10. Widefield imaging of upconverting nanoparticles on epifluorescence microscopes adapted for laser illumination with top-hat profile

    Science.gov (United States)

    Mrazek, Jiri; Pospisilova, Martina; Svozil, Vit; Cadek, Ondrej; Nesporova, Kristina; Sulakova, Romana; Brandejsova, Martina; Vranova, Jana; Velebny, Vladimir

    2016-05-01

    We describe a modification of epifluorescence microscopes that allows quantitative widefield imaging of samples labeled by upconverting nanoparticles (UCNP). A top-hat illumination profile on the sample was achieved with a 980-nm laser diode by using tandem microlens arrays, a moving diffuser and a telescope, which adjusts the top-hat area to the field of view. Illumination homogeneity is a critical factor for imaging of UCNP since the intensity of their luminescence typically scales with the second power of the excitation intensity. Our illuminator is combined with the epifluorescence attachment of the microscope, allowing easy switching between observation of UCNP and traditional fluorescent dyes. Illumination profile homogeneity of about 98% was measured for objectives with magnification from 4× to 100×, and the top-hat profile was also obtained with phase contrast objectives. We demonstrate capability of the illuminator by evaluating in vitro uptake of UCNP encapsulated in oleyl-hyaluronan micelles into breast cancer cells. Micelles bearing the targeting peptide were about an order of magnitude more efficient than nontargeted micelles.

  11. HAT inhibitor, garcinol, exacerbates lipopolysaccharide‑induced inflammation in vitro and in vivo.

    Science.gov (United States)

    Wang, Bin; Lin, Ling; Ai, Qing; Zeng, Tao; Ge, Pu; Zhang, Li

    2016-06-01

    Acetylation modification catalyzed by histone acetyl transferases (HATs) is important for transcriptional regulation. The present study investigated the effects of the HAT inhibitor garcinol on the expression of inflammation‑associated genes in lipopolysaccharide (LPS)‑stimulated RAW264.7 murine macrophages and LPS‑challenged mice. The levels of pro‑inflammatory cytokines were determined by reverse transcription‑quantitative polymerase chain reaction and enzyme‑linked immunosorbent assay. The degree of multi‑organ injury was evaluated by histopathological examination of the lung, determination of the alanine aminotransferase and blood urea nitrogen in plasma samples and by monitoring the survival rate of the experimental animals. The results of the current study demonstrated that garcinol promoted LPS‑induced expression of tumor necrosis factor‑α (TNF‑α) and interleukin‑6 (IL‑6) in RAW264.7 cells. These effects were associated with reduced acetylation of nuclear factor‑κB p65. Additionally, treatment with garcinol enhanced LPS‑induced expression of TNF‑α and IL‑6, exacerbated LPS‑induced lung injury, increased LPS‑induced elevation of plasma alanine aminotransferase and blood urea nitrogen, and reduced the survival rate of LPS‑challenged mice. These data indicated that the HAT inhibitor, garcinol, enhances LPS‑induced inflammation in vitro and in vivo, suggesting that acetylation modification has an important regulatory function during inflammation. PMID:27122221

  12. Ideologiekritik des E-Learnings. Welchen Nutzen hat die Einführung von E-Learning?

    Directory of Open Access Journals (Sweden)

    Katharina Kaiser-Müller

    2015-03-01

    Full Text Available Vor etwa sieben Jahren hat das damalige Bundesministerium für Unterricht, Kunst und Kultur (bm:ukk, das seit 2014 Bundesministerium für Bildung und Frauen (BMBF genannt wird, verschiedene Maßnahmen im Blick auf neuen Medien – insbesondere im Blick auf das E-Learning – gesetzt, um einen Beitrag zur Vorbereitung der Lernenden auf eine Informations- und Wissensgesellschaft zu leisten. E-Learning wurde als Erfolgsfaktor für die Zukunft gesehen und mit der Begründung, es fördere das individuelle und selbst gesteuerte Lernen, gefördert. Die zentrale Frage ist dabei: Welchen Nutzen hat die Einführung von E-Learning? In diesem Artikel wird dahingehend aufgezeigt, dass E-Learning nicht wegen pädagogischem Bedarf, sondern durch ministeriell gesetzte Maßnahmen eingeführt wurde und dadurch – wenn auch nicht bewusst und schon gar nicht als solches kommuniziert – neoliberale Strukturen durchgesetzt wurden. Die Einführung von E-Learning hat somit für deren Akzeptanz gesorgt.

  13. Energy versus centrality dependence of the jet quenching parameter $\\hat q$ at RHIC and LHC: a new puzzle?

    CERN Document Server

    Andrés, Carlota; Luzum, Matthew; Salgado, Carlos A; Zurita, Pía

    2016-01-01

    The central goal of jet quenching studies in high-energy nuclear collisions is the characterization of those QCD medium properties that are accessible by these probes. Most of the discussion in the last years has been focused on the determination of the jet quenching parameter, $\\hat q$. We present here an extraction of this parameter using data of inclusive particle suppression at RHIC and LHC energies for different centralities. Our approach consists of fitting a $K$ factor that quantifies the departure of this parameter from an ideal estimate, $K\\equiv \\hat q/(2\\epsilon^{3/4})$, where $\\hat q$ is determined by the local medium quantities as provided by hydrodynamical calculations. We find that this $K$ factor is larger at RHIC than at the LHC, as obtained already in previous analyses, but, surprisingly, it is almost independent of the centrality of the collision. Taken at face value, the $K$ factor would not depend on the local properties of the medium as energy density or temperature, but on global collis...

  14. Transmission spectroscopy of the inflated exo-Saturn HAT-P-19b

    Science.gov (United States)

    Mallonn, M.; von Essen, C.; Weingrill, J.; Strassmeier, K. G.; Ribas, I.; Carroll, T. A.; Herrero, E.; Granzer, T.; Claret, A.; Schwope, A.

    2015-08-01

    Context. Transiting highly inflated giant planets offer the possibility of characterizing their atmospheres. A fraction of the starlight passes through the high-altitude layers of the planetary atmosphere during transit. The resulting absorption is expected to be wavelength dependent for cloud-free atmospheres with an amplitude of up to 10-3 of the stellar flux, while a high-altitude cloud deck would cause a gray opacity. Aims: We observed the Saturn-mass and Jupiter-sized exoplanet HAT-P-19b to refine its transit parameters and ephemeris as well as to shed first light on its transmission spectrum. We monitored the host star over one year to quantify its flux variability and to correct the transmission spectrum for a slope caused by starspots. Methods: A transit of HAT-P-19b was observed spectroscopically with OSIRIS at the Gran Telescopio Canarias in January 2012. The spectra of the target and the comparison star covered the wavelength range from 5600 to 7600 Å. One high-precision differential light curve was created by integrating the entire spectral flux. This white-light curve was used to derive absolute transit parameters. Furthermore, a set of light curves over wavelength was formed by a flux integration in 41 wavelength channels of 50 Å width. We analyzed these spectral light curves for chromatic variations of transit depth. Results: The transit fit of the combined white-light curve yields a refined value of the planet-to-star radius ratio of 0.1390 ± 0.0012 and an inclination of 88.89 ± 0.32 deg. After a re-analysis of published data, we refine the orbital period to 4.0087844 ± 0.0000015 days. We obtain a flat transmission spectrum without significant additional absorption at any wavelength or any slope. However, our accuracy is not sufficient to significantly rule out the presence of a pressure-broadened sodium feature. Our photometric monitoring campaign allowed for an estimate of the stellar rotation period of 35.5 ± 2.5 days and an improved age

  15. Identification of a high frequency transposon induced by tissue culture, nDaiZ, a member of the hAT family in rice.

    Science.gov (United States)

    Huang, Jian; Zhang, Kewei; Shen, Yi; Huang, Zejun; Li, Ming; Tang, Ding; Gu, Minghong; Cheng, Zhukuan

    2009-03-01

    Recent completion of rice genome sequencing has revealed that more than 40% of its genome consists of repetitive sequences, and most of them are related to inactive transposable elements. In the present study, a transposable element, nDaiZ0, which is induced by tissue culture with high frequency, was identified by sequence analysis of an allelic line of the golden hull and internode 2 (gh2) mutant, which was integrated into the forth exon of GH2. The 528-bp nDaiZ0 has 14-bp terminal inverted repeats (TIRs), and generates an 8-bp duplication of its target sites (TSD) during its mobilization. nDaiZs are non-autonomous transposons and have no coding capacity. Bioinformatics analysis and southern blot hybridization showed that at least 16 copies of nDaiZ elements exist in the japonica cultivar Nipponbare genome and 11 copies in the indica cultivar 93-11 genome. During tissue culture, only one copy, nDaiZ9, located on chromosome 5 in the genome of Nipponbare can be activated with its transposable frequency reaching 30%. However, nDaiZ9 was not present in the 93-11 genome. The larger elements, DaiZs, were further identified by database searching using nDaiZ0 as a query because they share similar TIRs and subterminal sequences. DaiZ can also generate an 8-bp TSD. DaiZ elements contain a conserved region with a high similarity to the hAT dimerization motif, suggesting that the nDaiZ-DaiZ transposon system probably belongs to the hAT superfamily of class II transposons. Phylogenetic analysis indicated that it is a new type of plant hAT-like transposon. Although nDaiZ is activated by tissue culture, the high transposable frequency indicates that it could become a useful gene tagging system for rice functional genomic studies. In addition, the mechanism of the high transposable ability of nDaiZ9 is discussed. PMID:19071208

  16. Top hat single-mode polarization maintaining fiber and polarizing numerical design

    Science.gov (United States)

    Gouriou, Pierre; Scol, Florent; Sevigny, Benoit; Valentin, Constance; Quiquempois, Yves; Bigot, Laurent; Habert, Rémi; Cassez, Andy; Vanvincq, Olivier; Hugonnot, Emmanuel; Bouwmans, Geraud

    2016-03-01

    Compactness, long term stability and no free-space alignment are important advantages of fiber lasers over bulky systems. These fiber lasers have also demonstrated their capability to deliver high-power pulses and are thus suitable for numerous applications. Nevertheless the intensity profile delivered usually has a Gaussian-like shape, which most of the time is sufficient, but it could be interesting, for many applications (laser-biological tissues interactions, heat treatment, industrial laser processing or for seeding large-scale laser facilities like Laser MegaJoule) to obtain a homogeneous intensity profile at the fiber laser output. Moreover several of these applications required a linearly polarized output beam. In order to achieve all these requirements we have developed and realized a new fiber design. This fiber is the first polarization maintaining single-mode fiber delivering a flat top intensity. A high quality flat mode was obtained at 1.05μm through the use of a well-tailored index profile and single-mode behavior was verified by shifting the injection and using the S² imaging. Moreover, boron Stress Applying Parts (SAPs) including in the cladding led to a birefringence of 0.6x10-4 and a measured PER better than 20dB even for a long fiber length (~20 m). Alongside the fabrication, we developed a simulation code, using Comsol Multiphysics®, to take into account the stress dependency induced by the SAPs. Further modeling allows us to present an effectively single-mode fiber design, delivering a top-hat mode profile and exhibiting a polarizing behavior.

  17. A progressive black top hat transformation algorithm for estimating valley volumes on Mars

    Science.gov (United States)

    Luo, Wei; Pingel, Thomas; Heo, Joon; Howard, Alan; Jung, Jaehoon

    2015-02-01

    The depth of valley incision and valley volume are important parameters in understanding the geologic history of early Mars, because they are related to the amount sediments eroded and the quantity of water needed to create the valley networks (VNs). With readily available digital elevation model (DEM) data, the Black Top Hat (BTH) transformation, an image processing technique for extracting dark features on a variable background, has been applied to DEM data to extract valley depth and estimate valley volume. Previous studies typically use a single window size for extracting the valley features and a single threshold value for removing noise, resulting in finer features such as tributaries not being extracted and underestimation of valley volume. Inspired by similar algorithms used in LiDAR data analysis to remove above-ground features to obtain bare-earth topography, here we propose a progressive BTH (PBTH) transformation algorithm, where the window size is progressively increased to extract valleys of different orders. In addition, a slope factor is introduced so that the noise threshold can be automatically adjusted for windows with different sizes. Independently derived VN lines were used to select mask polygons that spatially overlap the VN lines. Volume is calculated as the sum of valley depth within the selected mask multiplied by cell area. Application of the PBTH to a simulated landform (for which the amount of erosion is known) achieved an overall relative accuracy of 96%, in comparison with only 78% for BTH. Application of PBTH to Ma'adim Vallies on Mars not only produced total volume estimates consistent with previous studies, but also revealed the detailed spatial distribution of valley depth. The highly automated PBTH algorithm shows great promise for estimating the volume of VN on Mars on global scale, which is important for understanding its early hydrologic cycle.

  18. VizieR Online Data Catalog: Spectroscopy and photometry of HATS-17 (Brahm+, 2016)

    Science.gov (United States)

    Brahm, R.; Jordan, A.; Bakos, G. A.; Penev, K.; Espinoza, N.; Rabus, M.; Hartman, J. D.; Bayliss, D.; Ciceri, S.; Zhou, G.; Mancini, L.; Tan, T. G.; de Val-Borro, M.; Bhatti, W.; Csubry, Z.; Bento, J.; Henning, T.; Schmidt, B.; Rojas, F.; Suc, V.; Lazar, J.; Papp, I.; Sari, P.

    2016-07-01

    The star HATS-17 was observed by HATSouth instruments between UT 2011 April 26 and UT 2012 July 31 using the HS-2 (on 2011 Apr-2012 Jul with r filter), HS-4 (on 2011 Jul-2012 Jul with r filter), and HS-6 (on 2011 May-2012 Jul with r filter) units at Las Campanas Observatory (LCO) in Chile, the High Energy Spectroscopic Survey (H.E.S.S.) site in Namibia, and Siding Spring Observatory (SSO) in Australia, respectively. The first photometric follow-up light curve of this system was obtained with the 0.3m Perth Exoplanet Survey Telescope (PEST) located near Perth on 2015 Apr 26 with a RC filter. Another two partial transits were then acquired with the Las Cumbres Observatory Global Telescope (LCOGT) 1m telescope network, specifically with the telescope at Cerro Tololo Inter-American Observatory (CTIO) on 2015 May 13 with i filter, and with the Swope 1m coupled with the e2v camera at Las Campanas Observatory (LCO) on 2015 May 29 with i filter. Finally, two partial transits of the same event were measured with high photometric precision (~1mmag). The observations were performed with the same two telescopes that registered the previous partial transits (Swope 1m/e2v (LCO) on 2015 Jul 17 with i filter, and LCOGT 1 m/sinistro (CTIO) on 2015 Jul 17 with i filter). Several high resolution spectra were acquired with three spectrographs installed in the ESO La Silla observatory. We obtained 11 spectra using HARPS at the ESO 3.6m telescope, 8 spectra using CORALIE, at the Euler 1.2m telescope and 2 spectra with FEROS at the MPG 2.2m telescope. Table2 provides the light curve data. Radial velocity and bisector span values are presented in Table3 with their corresponding uncertainties. (2 data files).

  19. Atmospheric, Orbital and Secondary Eclipse Analysis of HAT-P-30-WASP-51b

    Science.gov (United States)

    Foster, Andrew S.; Harrington, Joseph; Cubillos, Patricio; Blecic, Jasmina; Challener, Ryan; Foster, Austin James; Garland, Justin

    2016-01-01

    HAT-P-30-WASP-51b is a hot-Jupiter planet that orbits an F star every 2.8106 days at a distance of 0.0419 AU. Using the Spitzer Space Telescope in 2012 (Spitzer Program Number 70084) we observed two secondary eclipses of the planet, one in the 3.6 μm channel on 3 January and one in the 4.5 μm channel on 17 January. We present eclipse-depth measurements of 0.00163±0.0001 and 0.00146±0.00013 and we esitmate the infrared brightness temperatures to be 1900±50 and 1600±60 for these two channels, respectively, from an analysis using our Photometry for Orbits, Eclipses, and Transits (POET) pipeline. We also refine its orbit using our own secondary-eclipse measurements in combination with radial-velocity and transit observations from both professional and amateur observers. The most notable result from this orbital analysis is a detection of eccentricity in the planet's orbit. Using only the phase of our secondary eclipses, we can constrain ecosw to a minimum of 0.0084±0.0004, a 20 sigma detection of one component of the orbit's eccentricity that is independent of the effects that stellar tides have on radial velocity data. We then characterize its atmosphere's temperature- pressure profile and molecular abundances using our Bayesian Atmospheric Radiative Transfer code (BART). Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G. J. Blecic holds a NASA Earth and Space Sciences Fellowship.

  20. Sanitation conditions of clean food good taste restaurants in Hat Yai City Municipality

    Directory of Open Access Journals (Sweden)

    Sopon, A.

    2004-01-01

    Full Text Available Sanitation conditions and microbiological quality of 52 “Clean Food Good Taste” restaurants in Hat Yai city municipality were examined using a standard food sanitation survey checklist based on the Department of Health and Department of Medical Science, Ministry of Public Health. Coliform bacteria and Escherichia coli (E. coli were investigated in samples of foods and drinking water, whereas total bacterial count (TBC was carried out in samples of foods, plates, spoons, glasses and food handlers. The methods of investigation were the Most Probable Number (MPN method for coliform bacteria, E. coli and the standard plate count method for TBC. The SI-2 field test kit was used to indicate microbiological contamination, particularly coliform bacteria. It was found that 38/52 (73.1% restaurants passed all items of food sanitation standard. The food sanitation condition with the lowest number passing was the dressing of food handlers (45/52, 86.5% followed by the area for eating, preparing and cooking (47/52, 90.4%. Microbiological quality of food samples based on both MPN of coliform bacteria and E. coli was at an acceptable level in 190/202 samples (94.1%. However, in samples of drinking water only 19/52 (36.5% passed the MPN standard for coliform bacteria and 45/52 (86.5% that for E. coli. Moreover, among the 52 restaurants, the numbers (percentages passing the standard TBC in samples of plate, spoon, glass, cooker handlers and server handlers were 32 (61.5%, 27(51.9%, 20 (38.5%, 2 (3.9% and 1 (1.9%, respectively. Comparison of microbiological quality between the SI-2 test kit and MPN coliform/TBC showed no significant differences for samples of foods, but significant differences for the rest of the samples (p<0.05, t-test.

  1. Groundwater evolution beneath Hat Yai, a rapidly developing city in Thailand

    Science.gov (United States)

    Lawrence, A. R.; Gooddy, D. C.; Kanatharana, P.; Meesilp, W.; Ramnarong, V.

    2000-09-01

    Many cities and towns in South and Southeast Asia are unsewered, and urban wastewaters are often discharged either directly to the ground or to surface-water canals and channels. This practice can result in widespread contamination of the shallow groundwater. In Hat Yai, southern Thailand, seepage of urban wastewaters has produced substantial deterioration in the quality of the shallow groundwater directly beneath the city. For this reason, the majority of the potable water supply is obtained from groundwater in deeper semi-confined aquifers 30-50 m below the surface. However, downward leakage of shallow groundwater from beneath the city is a significant component of recharge to the deeper aquifer, which has long-term implications for water quality. Results from cored boreholes and shallow nested piezometers are presented. The combination of high organic content of the urban recharge and the shallow depth to the water table has produced strongly reducing conditions in the upper layer and the mobilisation of arsenic. A simple analytical model shows that time scales for downward leakage, from the surface through the upper aquitard to the semi-confined aquifer, are of the order of several decades. Résumé. De nombreuses villes du sud et du sud-est de l'Asie ne possèdent pas de réseaux d'égouts et les eaux usées domestiques s'écoulent souvent directement sur le sol ou dans des canaux et des cours d'eau de surface. Ces pratiques peuvent provoquer une contamination dispersée de la nappe phréatique. A Hat Yai (sud de la Thaïlande), les infiltrations d'eaux usées domestiques sont responsables d'une détérioration notable de la qualité de la nappe phréatique directement sous la ville. Pour cette raison, la majorité de l'eau potable est prélevée dans des aquifères semi-captifs plus profonds, situés entre 30 et 50 m sous la surface. Cependant, une drainance à partir de la nappe phréatique sous la ville constitue une composante significative de la recharge

  2. Treatment efficiency in wastewater treatment plant of Hat Yai Municipality by quantitative removal of microbial indicators

    Directory of Open Access Journals (Sweden)

    Duangporn Kantachote

    2009-11-01

    Full Text Available The efficiency of treatment in a wastewater treatment plant of Hat Yai Municipality through stabilization ponds and constructed wetlands was monitored by using the bacterial indicators, total coliforms (TC, fecal coliforms (FC, Escherichia coli and fecal streptococci (FS, and photosynthetic microbes. The sequence of water flow in the wastewater treatment plant is as follows: primary or anaerobic pond (P, facultative pond (F, maturation pond (M, constructed wetlands (W1, W2 and W3, and an effluent storage pond (S for the treated wastewater. The wastewater treatment plant has an approximate area of 3,264,000 m2 (2,040 rai and its dry weather flow was running at only 40,000 m3/ day. There were 10 sampling times used for all the 7 ponds during July-October, 2006.Statistical analysis using a Two-Factorial Design model, indicated that pond types significantly affected temperature, dissolved oxygen (DO, and pH (p<0.05, whereas the time of sampling during the day had a significant effect (p<0.05 only on the temperature and light intensity available to the ponds. There were also significant different removal efficiencies of the different bacterial indicator groups tested (p<0.05. The overall performance of the wastewater treatment plant effectively removed TC, FC, E. coli, and FS as follows, 99.8%, 99.8%, 75.8% and 98.8%, respectively. The amounts of bacterial indicators, except for E. coli, showed a negative correlation with levels of light intensity and DO, whereas there was no correlation between the pH and the different indicator bacteria. There was a positive middle level correlation between pHand chlorophyll a.There were five different divisions of photosynthetic organisms detected throughout the plant as follows, Cyanophyta, Chlorophyta, Bacillariophyta, Euglenophyta, and Pyrrhophyta. The least diversity was found in the anaerobic pond (P as there were only 15 genera. Euglena, an indicator of dirty water, was detected only in this pond. The

  3. Assessment of efficiency of water supply system in Prince of Songkla University, Hat Yai Campus

    Directory of Open Access Journals (Sweden)

    Chaivisit, P.

    2007-03-01

    Full Text Available Assessment of efficiency of water production system in Prince of Songkla University, Hat Yai Campus, was conducted in this study. Topics covered include 1 quality and quantity of raw water, 2 water productionprocess, 3 management and maintenance of water production system, and 4 quality of finished water. Totally, 494 water samples were collected during the study. All water samples were analyzed for turbidity,pH, temperature, conductivity, TDS, total coliforms, fecal coliforms and residual chlorine. In addition to the mentioned parameters, 30 of these water samples were also analyzed for hardness, chloride, nitratenitrogen,sulfate and heavy metals (manganese, copper, zinc, iron, chromium, cadmium, lead and mercury. All water samples were collected during November, 2004 (rainy season and March, 2005 (summer season.It was found that the quality of the water in the Sritrang reservoir fell into Class 2 of Thailand Surface Water Quality Standard that requires ordinary water treatment processes prior to consumptions.Cadmium, lead and mercury were not detected by Inductively Coupled Plasma (ICP method. There are 2 sets of water production system. The first set consists of 4 pressure filters which could reduce turbidity atvarying efficiencies: 33.83%, 18.26%, 42.76% and 65.67% depending mainly on the extent of chemical dosing control and the maintenance of the filter media. Another system employed sedimentation tank andrapid sand filter, which could remove turbidity at 89.28%. When combined finished water from both systems were analyzed, it was found that removals of manganese, copper, zinc, iron and chromium were 42.65%,30.02%, 19.54%, 56.82% and 15.12%, respectively. Residual chlorine concentration of the finished water was not more than 0.2 mg/L and no total coliforms or fecal coliforms were detected. The plant had sufficientand competent personnel to carry out their normal tasks but occasional negligence and lack of specific water testing or

  4. Hat intrathekal appliziertes Baclofen (Lioresal) einen neuroprotektiven Effekt im 4-Gefäßverschlussmodell der Ratte?

    OpenAIRE

    Stubenvoll, Florian Michael

    2015-01-01

    Einleitung: Im 4-Gefäßverschlussmodell der Ratte wird überprüft, ob intrathekal appliziertes Baclofen einen neuroprotektiven Effekt hat. Material und Methoden: Hierzu werden zunächst 1µg/5µl Baclofen über 5 Minuten beginnend 30 Minuten vor einer 10-minütigen zerebralen Ischämie bei männlichen Wistar-Ratten intrazerebroventrikulär appliziert und gegen eine Kontrollgruppe verglichen, dann werden 2µg/5µl Baclofen über 5 Minu...

  5. The TopHat Experiment: A Balloon-Borne Instrument for Mapping Millimeter and Sub-Millimeter Emission

    DEFF Research Database (Denmark)

    Silverberg, R. F.; Cheng, E. S.; Aguirre, J. E.;

    2005-01-01

    The TopHat experiment was designed to measure the anisotropy in the cosmic microwave background radiation on angular scales from 03 to 30° and the thermal emission from both Galactic and extragalactic dust. The balloon‐borne instrument had five spectral bands spanning frequencies from 175 to 630...... GHz. The telescope was a compact, 1 m, on‐axis Cassegrain telescope designed to scan the sky at a fixed elevation of 78°. The radiometer used cryogenic bolometers coupled to a single feed horn via a dichroic filter system. The observing strategy was intended to efficiently cover a region 48° in...

  6. A high precision chemical abundance analysis of the HAT-P-1 stellar binary: constraints on planet formation

    OpenAIRE

    Liu, F; Asplund, M.; Ramirez, I.; Yong, D.; Melendez, J.

    2014-01-01

    We present a high-precision, differential elemental abundance analysis of the HAT-P-1 stellar binary based on high-resolution, high signal-to-noise ratio Keck/HIRES spectra. The secondary star in this double system is known to host a transiting giant planet while no planets have yet been detected around the primary star. The derived metallicities ([Fe/H]) of the primary and secondary stars are identical within the errors: $0.146 \\pm 0.014$ dex ($\\sigma$ = 0.033 dex) and $0.155 \\pm 0.007$ dex ...

  7. The GTC exoplanet transit spectroscopy survey. IV. Confirmation of the flat transmission spectrum of HAT-P-32b

    Science.gov (United States)

    Nortmann, L.; Pallé, E.; Murgas, F.; Dreizler, S.; Iro, N.; Cabrera-Lavers, A.

    2016-10-01

    We observed the hot Jupiter HAT-P-32b (also known as HAT-P-32Ab) to determine its optical transmission spectrum by measuring the wavelength-dependent, planet-to-star radius ratios in the region between 518-918 nm. We used the OSIRIS instrument at the Gran Telescopio CANARIAS (GTC) in long-slit spectroscopy mode, placing HAT-P-32 and a reference star in the same slit and obtaining a time series of spectra covering two transit events. Using the best quality data set, we were able to yield 20 narrowband transit light curves, with each passband spanning a 20 nm wide interval. After removal of all systematic noise signals and light curve modeling, the uncertainties for the resulting radius ratios lie between 337 and 972 ppm. The radius ratios show little variation with wavelength, suggesting a high altitude cloud layer masking any atmospheric features. Alternatively, a strong depletion in alkali metals or a much smaller than expected planetary atmospheric scale height could be responsible for the lack of atmospheric features. Our result of a flat transmission spectrum is consistent with a previous ground-based study of the optical spectrum of this planet. This agreement between independent results demonstrates that ground-based measurements of exoplanet atmospheres can give reliable and reproducible results despite the fact that the data often is heavily affected by systematic noise as long as the noise source is well understood and properly corrected. We also extract an optical spectrum of the M-dwarf companion HAT-P-32B. Using PHOENIX stellar atmosphere models we determine an effective temperature of Teff = 3187+60-71 K, which is slightly colder than previous studies relying only on broadband infrared data. The 20 narrowband and white light curves are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/594/A65

  8. How a Hat May Affect 3-Month-Olds' Recognition of a Face: An Eye-Tracking Study.

    OpenAIRE

    Hermann Bulf; Eloisa Valenza; Chiara Turati

    2013-01-01

    Recent studies have shown that infants’ face recognition rests on a robust face representation that is resilient to a variety of facial transformations such as rotations in depth, motion, occlusion or deprivation of inner/outer features. Here, we investigated whether 3-month-old infants’ ability to represent the invariant aspects of a face is affected by the presence of an external add-on element, i.e. a hat. Using a visual habituation task, three experiments were carried out in which face re...

  9. Top-hat beam output of a single-mode micro-structured optical fiber: Impact of core index depression

    International Nuclear Information System (INIS)

    A new strategy to obtain a single-mode fiber with a flattened intensity profile distribution is presented. It is based on the use of an OVD made high index ring deposited on a silica rod having a refractive index slightly lower than the silica used for the micro-structured cladding. Using this strategy, we realized the first single-mode fiber with a quasi-perfect top-hat intensity profile around 1 μm. Numerical studies clearly demonstrate the advantage of using a core index depression to insure the single-mode operation of the fiber at the working wavelength. (authors)

  10. Valproic acid exposure decreases Cbp/p300 protein expression and histone acetyltransferase activity in P19 cells.

    Science.gov (United States)

    Lamparter, Christina L; Winn, Louise M

    2016-09-01

    The teratogenicity of the antiepileptic drug valproic acid (VPA) is well established and its inhibition of histone deacetylases (HDAC) is proposed as an initiating factor. Recently, VPA-mediated HDAC inhibition was demonstrated to involve transcriptional downregulation of histone acetyltransferases (HATs), which was proposed to compensate for the increased acetylation resulting from HDAC inhibition. Cbp and p300 are HATs required for embryonic development and deficiencies in either are associated with congenital malformations and embryolethality. The objective of the present study was to characterize Cbp/p300 following VPA exposure in P19 cells. Consistent with previous studies, exposure to 5mM VPA over 24h induced a moderate decrease in Cbp/p300 mRNA, which preceded a strong decrease in total cellular protein mediated by ubiquitin-proteasome degradation. Nuclear Cbp/p300 protein was also decreased following VPA exposure, although to a lesser extent. Total cellular and nuclear p300 HAT activity was reduced proportionately to p300 protein levels, however while total cellular HAT activity also decreased, nuclear HAT activity was unaffected. Using the Cbp/p300 HAT inhibitor C646, we demonstrated that HAT inhibition similarly affected many of the same endpoints as VPA, including increased reactive oxygen species and caspase-3 cleavage, the latter of which could be attenuated by pre-treatment with the antioxidant catalase. C646 exposure also decreased NF-κB/p65 protein, which was not due to reduced mRNA and was not attenuated with catalase pre-treatment. This study provides support for an adaptive HAT response following VPA exposure and suggests that reduced Cbp/p300 HAT activity could contribute to VPA-mediated alterations. PMID:27381264

  11. HAT-P-57b: A Short-Period Giant Planet Transiting A Bright Rapidly Rotating A8V Star Confirmed Via Doppler Tomography

    CERN Document Server

    Hartman, J D; Buchhave, L A; Torres, G; Latham, D W; Kovács, G; Bhatti, W; Csubry, Z; de Val-Borro, M; Penev, K; Huang, C X; Béky, B; Bieryla, A; Quinn, S N; Howard, A W; Marcy, G W; Johnson, J A; Isaacson, H; Fischer, D A; Noyes, R W; Falco, E; Esquerdo, G A; Knox, R P; Hinz, P; Lázár, J; Papp, I; Sári, P

    2015-01-01

    We present the discovery of HAT-P-57b, a P = 2.4653 day transiting planet around a V = 10.465 +- 0.029 mag, Teff = 7500 +- 250 K main sequence A8V star with a projected rotation velocity of v sin i = 102.1 +- 1.3 km s^-1. We measure the radius of the planet to be R = 1.413 +- 0.054 R_J and, based on RV observations, place a 95% confidence upper limit on its mass of M < 1.85 M_J . Based on theoretical stellar evolution models, the host star has a mass and radius of 1.47 +- 0.12 M_sun, and 1.500 +- 0.050 R_sun, respectively. Spectroscopic observations made with Keck-I/HIRES during a partial transit event show the Doppler shadow of HAT-P-57b moving across the average spectral line profile of HAT-P- 57, confirming the object as a planetary system. We use these observations, together with analytic formulae that we derive for the line profile distortions, to determine the projected angle between the spin axis of HAT-P-57 and the orbital axis of HAT-P-57b. The data permit two possible solutions, with -16.7 deg &l...

  12. HAT-P-65b and HAT-P-66b: Two Transiting Inflated Hot Jupiters and Observational Evidence for the Re-Inflation of Close-In Giant Planets

    CERN Document Server

    Hartman, Joel D; Bhatti, Waqas; Penev, Kaloyan; Bieryla, Allyson; Latham, David W; Kovács, Géza; Torres, Guillermo; Csubry, Zoltan; de Val-Borro, Miguel; Buchhave, Lars; Kovács, Tamás; Quinn, Samuel; Howard, Andrew W; Isaacson, Howard; Fulton, Benjamin J; Everett, Mark E; Esquerdo, Gilbert A; Béky, Bence; Szklenar, Tamás; Falco, Emilio; Santerne, Alexandre; Boisse, Isabelle; Hébrard, Guillaume; Burrows, Adam; Lázár, Jozsef; Papp, István; Sári, Pál

    2016-01-01

    We present the discovery of the transiting exoplanets HAT-P-65b and HAT-P-66b, with orbital periods of 2.6055 d and 2.9721 d, masses of $0.527 \\pm 0.083$ M$_{J}$ and $0.783 \\pm 0.057$ M$_{J}$ and inflated radii of $1.89 \\pm 0.13$ R$_{J}$ and $1.59^{+0.16}_{-0.10}$ R$_{J}$, respectively. They orbit moderately bright ($V=13.145 \\pm 0.029$, and $V=12.993 \\pm 0.052$) stars of mass $1.212 \\pm 0.050$ M$_{\\odot}$ and $1.255^{+0.107}_{-0.054}$ M$_{\\odot}$. The stars are at the main sequence turnoff. While it is well known that the radii of close-in giant planets are correlated with their equilibrium temperatures, whether or not the radii of planets increase in time as their hosts evolve and become more luminous is an open question. Looking at the broader sample of well-characterized close-in transiting giant planets, we find that there is a statistically significant correlation between planetary radii and the fractional ages of their host stars, with a false alarm probability of only 0.0041%. We find that the correla...

  13. A high obliquity orbit for the hot-Jupiter HATS-14b transiting a 5400K star

    CERN Document Server

    Zhou, G; Hartman, J D; Fulton, B J; Bakos, G Á; Howard, A W; Isaacson, H; Marcy, G W; Schmidt, B P; Brahm, R; Jordán, A

    2015-01-01

    We report a spin-orbit misalignment for the hot-Jupiter HATS-14b, measuring a projected orbital obliquity of |lambda|= 76 -5/+4 deg. HATS-14b orbits a high metallicity, 5400 K G dwarf in a relatively short period orbit of 2.8 days. This obliquity was measured via the Rossiter-McLaughlin effect, obtained with observations from Keck-HIRES. The velocities were extracted using a novel technique, optimised for low signal-to-noise spectra, achieving a high precision of 4 m/s point-to-point scatter. However, we caution that our uncertainties may be underestimated. Due to the low rotational velocity of the star, the detection significance is dependent on the vsini prior that is imposed in our modelling. Based on trends observed in the sample of hot Jupiters with obliquity measurements, it has been suggested that these planets modify the spin axes of their host stars, with an efficiency that depends on the stellar type and orbital period of the system. In this framework, short-period planets around stars with surface ...

  14. Relating $\\hat{q}$, $\\eta/s$ and $\\Delta E$ in an expanding Quark-Gluon Plasma

    CERN Document Server

    Ayala, Alejandro; Jalilian-Marian, Jamal; Tejeda-Yeomans, Maria Elena

    2016-01-01

    We use linear viscous hydrodynamics to describe the energy and momentum deposited by a fast moving parton in a quark gluon plasma. This energy-momentum is in turn used to compute the probability density for the production of soft partons by means of the Cooper-Frye formula. We use this probability density to render manifest a relation between the average transverse momentum given to the fast moving parton from the medium $\\hat{q}$, the entropy density to shear viscosity ratio $\\eta/s$ and the energy lost by the fast moving parton $\\Delta E$ in an expanding medium under similar conditions to those generated in nucleus-nucleus collisions at the LHC. We find that $\\hat{q}$ increases linearly with $\\Delta E$ for both trigger and away side partons that have been produced throughout the medium. On the other hand, $\\eta/s$ is more stable with $\\Delta E$. We also study how these transport coefficients vary with the geometrical location of the hard scattering that produces the fast moving partons. The behavior of $\\ha...

  15. HAT-P-13b,c: a transiting hot Jupiter with a massive outer companion on an eccentric orbit

    CERN Document Server

    Bakos, G A; Noyes, R W; Hartman, J; Torres, G; Kovacs, Geza; Fischer, D A; Latham, D W; Johnson, J A; Marcy, G W; Sasselov, D D; Stefanik, R P; Sipocz, B; Kovacs, Gabor; Esquerdo, G A; Pal, A; Lázár, J; Papp, I

    2009-01-01

    We report on the discovery of a planetary system with a close-in transiting hot Jupiter on a near circular orbit and a massive outer planet on a highly eccentric orbit. The inner planet, HAT-P-13b, transits the bright V=10.622 G4 dwarf star GSC 3416-00543 every P = 2.916260 \\pm 0.000010 days, with transit epoch Tc = 2454779.92979 \\pm 0.00038 (BJD) and duration 0.1345 \\pm 0.0017 d. The outer planet, HAT-P-13c orbits the star with P2 = 428.5 \\pm 3.0 days and nominal transit center (assuming zero impact parameter) of T2c = 2454870.4 \\pm 1.8 (BJD) or time of periastron passage T2,peri= 2454890.05 \\pm 0.48 (BJD). Transits of the outer planet have not been observed, and may not be present. The host star has a mass of 1.22+0.05-0.10Msun, radius of 1.56 \\pm 0.08 Rsun, effective temperature 5638 \\pm 90K, and is rather metal rich with [Fe/H] = +0.43\\pm0.08. The inner planetary companion has a mass of 0.851+/0.029-/0.046 Mjup, and radius of 1.280\\pm0.079 Rjup yielding a mean density of 0.499+/0.103-/0.069 gcm-3 . The ou...

  16. A SEARCH FOR WATER IN THE ATMOSPHERE OF HAT-P-26b USING LDSS-3C

    Energy Technology Data Exchange (ETDEWEB)

    Stevenson, Kevin B.; Bean, Jacob L.; Seifahrt, Andreas; Gilbert, Gregory J. [Department of Astronomy and Astrophysics, University of Chicago, 5640 S Ellis Avenue, Chicago, IL 60637 (United States); Line, Michael R. [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Désert, Jean-Michel [Anton Pannekoek Institute for Astronomy, University of Amsterdam, Amsterdam (Netherlands); Fortney, Jonathan J., E-mail: kbs@uchicago.edu [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States)

    2016-02-01

    The characterization of a physically diverse set of transiting exoplanets is an important and necessary step toward establishing the physical properties linked to the production of obscuring clouds or hazes. It is those planets with identifiable spectroscopic features that can most effectively enhance our understanding of atmospheric chemistry and metallicity. The newly commissioned LDSS-3C instrument on Magellan provides enhanced sensitivity and suppressed fringing in the red optical, thus advancing the search for the spectroscopic signature of water in exoplanetary atmospheres from the ground. Using data acquired by LDSS-3C and the Spitzer Space Telescope, we search for evidence of water vapor in the transmission spectrum of the Neptune-mass planet HAT-P-26b. Our measured spectrum is best explained by the presence of water vapor, a lack of potassium, and either a high-metallicity, cloud-free atmosphere or a solar-metallicity atmosphere with a cloud deck at ∼10 mbar. The emergence of multi-scale-height spectral features in our data suggests that future observations at higher precision could break this degeneracy and reveal the planet’s atmospheric chemical abundances. We also update HAT-P-26b’s transit ephemeris, t{sub 0} = 2455304.65218(25) BJD{sub TDB}, and orbital period, p = 4.2345023(7) days.

  17. A high precision chemical abundance analysis of the HAT-P-1 stellar binary: constraints on planet formation

    CERN Document Server

    Liu, F; Ramirez, I; Yong, D; Melendez, J

    2014-01-01

    We present a high-precision, differential elemental abundance analysis of the HAT-P-1 stellar binary based on high-resolution, high signal-to-noise ratio Keck/HIRES spectra. The secondary star in this double system is known to host a transiting giant planet while no planets have yet been detected around the primary star. The derived metallicities ([Fe/H]) of the primary and secondary stars are identical within the errors: $0.146 \\pm 0.014$ dex ($\\sigma$ = 0.033 dex) and $0.155 \\pm 0.007$ dex ($\\sigma$ = 0.023 dex), respectively. Extremely precise differential abundance ratios of 23 elements have been measured (mean error of $\\sigma$([X/Fe]) = 0.013 dex) and are found to be indistinguishable between the two stars: $\\Delta$[X/Fe] (secondary - primary) = $+0.001 \\pm 0.006$ dex ($\\sigma$ = 0.008 dex). The striking similarity in the chemical composition of the two stellar components in HAT-P-1 is contrary to the possible 0.04 dex level difference seen in 16 Cyg A+B, which also hosts a giant planet, at least 3 time...

  18. KEPLER'S OPTICAL SECONDARY ECLIPSE OF HAT-P-7b AND PROBABLE DETECTION OF PLANET-INDUCED STELLAR GRAVITY DARKENING

    International Nuclear Information System (INIS)

    We present observations spanning 355 orbital phases of HAT-P-7 observed by Kepler from 2009 May to 2011 March (Q1-9). We find a shallower secondary eclipse depth than initially announced, consistent with a low optical albedo and detection of nearly exclusively thermal emission, without a reflected light component. We find an approximately 10 ppm perturbation to the average transit light curve near phase –0.02 that we attribute to a temperature decrease on the surface of the star, phased to the orbit of the planet. This cooler spot is consistent with planet-induced gravity darkening, slightly lagging the sub-planet position due to the finite response time of the stellar atmosphere. The brightness temperature of HAT-P-7b in the Kepler bandpass is TB = 2733 ± 21 K and the amplitude of the deviation in stellar surface temperature due to gravity darkening is approximately –0.18 K. The detection of the spot is not statistically unequivocal due its small amplitude, though additional Kepler observations should be able to verify the astrophysical nature of the anomaly.

  19. Analysis of spin-orbit alignment in the WASP-32, WASP-38, and HAT-P-27/WASP-40 systems

    CERN Document Server

    Brown, D J A; Díaz, R F; Doyle, A P; Gillon, M; Lendl, M; Smalley, B; Triaud, A H M J; Anderson, D R; Enoch, B; Hellier, C; Maxted, P F L; Miller, G R M; Pollacco, D; Queloz, D; Boisse, I; Hébrard, G; 10.1088/0004-637X/760/2/139

    2013-01-01

    We present measurements of the spin-orbit alignment angle, lambda, for the hot Jupiter systems WASP-32, WASP-38, and HAT-P-27/WASP-40, based on data obtained using the HARPS spectrograph. We analyse the Rossiter-McLaughlin effect for all three systems, and also carry out Doppler tomography for WASP-32 and WASP-38. We find that WASP-32 (T_eff = 6140 +90 -100 K) is aligned, with an alignment angle of lambda = 10.5 +6.4 -6.5 degrees obtained through tomography, and that WASP-38 (T_eff = 6180 +40 -60 K) is also aligned, with tomographic analysis yielding lambda = 7.5 +4.7 -6.1 degrees. This latter result provides an order of magnitude improvement in the uncertainty in lambda compared to the previous analysis of Simpson et al. (2011). We are only able to loosely constrain the angle for HAT-P-27/WASP-40 (T_eff = 5190 +160 -170 K) to lambda = 24.2 +76.0 -44.5 degrees, owing to the poor signal-to-noise of our data. We consider this result a non-detection under a slightly updated version of the alignment test of Brown...

  20. Transmission spectroscopy of HAT-P-32b with the LBT: confirmation of clouds/hazes in the planetary atmosphere

    CERN Document Server

    Mallonn, Matthias

    2016-01-01

    Spectroscopic observations of a transit event of an extrasolar planet offer the opportunity to study the composition of the planetary atmosphere. We observed a transit of the inflated Hot Jupiter HAT-P-32b with MODS at the LBT to characterize its atmosphere from 3300 to 10000 AA. A time series of target and reference star spectra was binned in two broad-band wavelength channels, from which differential transit light curves were constructed. These broad-band light curves were used to confirm previous transit parameter determinations. To derive the planetary transmission spectrum with a resolution of R ~ 60, we created a chromatic set of 62 narrow-band light curves with an average wavelength width of about 100 AA. The spectrum was corrected for the third-light of a near-by M star, whose spectrum was resolved in the individual exposures. Additionally, we undertook a photometric monitoring campaign of the host star to correct for the influence of starspots. The transmission spectrum of HAT-P-32b shows no pressure...

  1. HAT-P-56b: A bright highly inflated massive Hot Jupiter around An F star in K2.0 field

    Science.gov (United States)

    Huang, Xu; Bakos, Gaspar; Hartman, Joel

    2015-08-01

    We report the discovery of HAT-P-56b, a transiting high inflated hot-jupiter orbiting a F type star in the field 0 of the NASA K2 mission, by the HATNet survey. We combine ground-based photometric light curves with the highprecision photometry obervation by the K2 mission, as well as radial velocity to determine the physical properties of this system. HAT-P-56b has a mass around ~2.2 Mjunp, a radius of ~1.5 Rjup, and transits its host star with a period of 2.79d. The host star has a V band magnitude of 10.9, Mass of 1.29 Msun, and radius of 1.433 Rsun. The radius of HAT-P-56b is among one of the largest compare to planets with similar mass, making it an interesting target for following up atmospherical observations.

  2. Origin and potential geothermal significance of China Hat and other late Pleistocene topaz rhyolite lava domes of the Blackfoot Volcanic Field, SE Idaho

    Science.gov (United States)

    McCurry, M. O.; Pearson, D. M.; Welhan, J. A.; Kobs-Nawotniak, S. E.; Fisher, M. A.

    2014-12-01

    The Snake River Plain and neighboring regions are well known for their high heat flow and robust Neogene-Quaternary tectonic and magmatic activity. Interestingly, however, there are comparatively few surficial manifestations of geothermal activity. This study is part of a renewed examination of this region as a possible hidden or blind geothermal resource. We present a testable, integrated volcanological, petrogenetic, tectonic and hydrothermal conceptual model for 57 ka China Hat and cogenetic topaz rhyolite lava domes of the Blackfoot Volcanic Field. This field is well suited for analysis as a blind resource because of its distinctive combination of (1) young bimodal volcanism, petrogenetic evidence of shallow magma storage and evolution, presence of coeval extension, voluminous travertine deposits, and C- and He-isotopic evidence of active magma degassing; (2) a paucity of hot springs or other obvious indicators of a geothermal resource in the immediate vicinity of the lava domes; and (3) proximity to a region of high crustal heat flow, high-T geothermal fluids at 2.5-5 km depth and micro-seismicity characterized by its swarming nature. Eruptions of both basalt and rhyolite commonly evolve from minor phreatomagmatic to effusive. In our model, transport of both magmatic and possible deep crustal aqueous fluids may be controlled by preexisting crustal structures, including west-dipping thrust faults. Geochemical evolution of rhyolite magma is dominated by mid- to upper-crustal fractional crystallization (with pre-eruption storage and phenocryst formation at ~14 km). Approximately 1.2 km3 of topaz rhyolite have been erupted since 1.4 Ma, yielding an average eruption rate of 0.8 km3/m.y. Given reasonable assumptions of magma cumulate formation and eruption rates, and initial and final volatile concentrations, we infer average H2O and CO2 volatile fluxes from the rhyolite source region of ~2MT/year and 340 T/day, respectively. Lithium flux may be comparable to CO2.

  3. Physical properties of the HAT-P-23 and WASP-48 planetary systems from multi-colour photometry

    Science.gov (United States)

    Ciceri, S.; Mancini, L.; Southworth, J.; Bruni, I.; Nikolov, N.; D'Ago, G.; Schröder, T.; Bozza, V.; Tregloan-Reed, J.; Henning, Th.

    2015-05-01

    Context. Accurate and repeated photometric follow-up observations of planetary transit events are important to precisely characterize the physical properties of exoplanets. A good knowledge of the main characteristics of the exoplanets is fundamental in order to trace their origin and evolution. Multi-band photometric observations play an important role in this process. Aims: By using new photometric data, we computed precise estimates of the physical properties of two transiting planetary systems at equilibrium temperatures of ~2000 K. Methods: We present new broadband, multi-colour photometric observations obtained using three small class telescopes and the telescope-defocussing technique. In particular we obtained 11 and 10 light curves covering 8 and 7 transits of HAT-P-23 and WASP-48, respectively. For each of the two targets, one transit event was simultaneously observed through four optical filters. One transit of WASP-48 b was monitored with two telescopes from the same observatory. The physical parameters of the systems were obtained by fitting the transit light curves with jktebop and from published spectroscopic measurements. Results: We have revised the physical parameters of the two planetary systems, finding a smaller radius for both HAT-P-23 b and WASP-48 b, Rb = 1.224 ± 0.037 RJup and Rb = 1.396 ± 0.051 RJup, respectively, than those measured in the discovery papers (Rb = 1.368 ± 0.090 RJup and Rb = 1.67 ± 0.10 RJup). The density of the two planets are higher than those previously published (ρb ~ 1.1 and ~0.3 ρjup for HAT-P-23 and WASP-48, respectively) hence the two hot Jupiters are no longer located in a parameter space region of highly inflated planets. An analysis of the variation of the planet's measured radius as a function of optical wavelength reveals flat transmission spectra within the experimental uncertainties. We also confirm the presence of the eclipsing contact binary NSVS-3071474 in the same field of view of WASP-48, for which

  4. Coupling quantum dots to optical fiber: Low pump threshold laser in the red with a near top hat beam profile

    International Nuclear Information System (INIS)

    Direct coupling of the optical field in a ∼244 nm thick, CdSe/ZnS quantum dot film to an optical fiber has yielded lasing in the red (λ ∼ 644 nm) with a threshold pump energy density < 2.6 mJ cm−2. Comprising 28–31 layers of ∼8 nm diameter quantum dots deposited onto the exterior surface of a 125 μm diameter coreless silica fiber, this free-running oscillator produces 134 nJ in 3.6 ns FWHM pulses which correspond to 37 W of peak power from an estimated gain volume of ∼4.5 × 10−7 cm3. Lasing was confirmed by narrowing of the output optical radiation in both the spectral and temporal domains, and the laser beam intensity profile approximates a top hat

  5. Importance of energy and angular resolutions in top-hat electrostatic analysers for solar wind proton measurements

    Science.gov (United States)

    De Marco, R.; Marcucci, M. F.; Bruno, R.; D'Amicis, R.; Servidio, S.; Valentini, F.; Lavraud, B.; Louarn, P.; Salatti, M.

    2016-08-01

    We use a numerical code which reproduces the angular/energy response of a typical top-hat electrostatic analyser starting from solar wind proton velocity distribution functions (VDFs) generated by numerical simulations. The simulations are based on the Hybrid Vlasov-Maxwell numerical algorithm which integrates the Vlasov equation for the ion distribution function, while the electrons are treated as a fluid. A virtual satellite launched through the simulation box measures the particle VDFs. Such VDFs are moved from the simulation Cartesian grid to energy-angular coordinates to mimic the response of a real sensor in the solar wind. Different energy-angular resolutions of the analyser are investigated in order to understand the influence of the phase-space resolution in existing and upcoming space missions, with regards to determining the key parameters of plasma dynamics.

  6. Classical and Mexican hat-type potential energy curve for the hydrogen molecule from a confined Kratzer oscillator

    Science.gov (United States)

    van Hooydonk, G.

    2016-03-01

    We review harmonic oscillator theory for closed, stable quantum systems. The H2 potential energy curve (PEC) of Mexican hat-type, calculated with a confined Kratzer oscillator, is better than the Rydberg-Klein-Rees (RKR) H2 PEC. Compared with QM, the theory of chemical bonding is simplified, since a confined Kratzer oscillator can also lead to the long sought for universal function, once called the Holy Grail of Molecular Spectroscopy. This is validated by reducing PECs for different bonds H2, HF, I2, N2 and O2 to a single one. The equal probability for H2, originating either from HA + HB or HB + HA, is quantified with a Gauss probability density function. At the Bohr scale, a confined harmonic oscillator behaves properly at the extremes of bound two-nucleon quantum systems.

  7. The Spectrum of Integrated Millimeter Flux of the Magellanic Clouds and 30-Doradus from TopHat and DIRBE Data

    CERN Document Server

    Aguirre, J E; Cheng, E S; Cottingham, D A; Cordone, S S; Crawford, T M; Fixsen, D J; Knox, L; Meyer, S S; Norgaard-Nielsen, H U; Silverberg, R F; Timbie, P; Wilson, G W

    2003-01-01

    We present measurements of the integrated flux relative to the local background of the Large and Small Magellanic Clouds and the region 30-Doradus (the Tarantula Nebula) in the LMC in four frequency bands centered at 245, 400, 460, and 630 GHz, based on observations made with the TopHat telescope. We combine these observations with the corresponding measurements for the DIRBE bands 8, 9, and 10 to cover the frequency range 245 - 3000 GHz (100 - 1220 micrometers) for these objects. We present spectra for all three objects and fit these spectra to a single-component greybody emission model and report best-fit dust temperatures, optical depths, and emissivity power-law indices, and we compare these results with other measurements in these regions and elsewhere. Using published dust grain opacities, we estimate the mass of the measured dust component in the three regions.

  8. Is $\\hat{q}$ a physical quantity or just a parameter? and other unanswered questions in High-$p_T$ Physics

    CERN Document Server

    Tannenbaum, M J

    2015-01-01

    The many different theoretical studies of energy loss of a quark or gluon traversing a medium have one thing in common: the transport coefficient of a gluon in the medium, $\\hat{q}$, which is defined as the mean 4-momentum transfer$^2$, $\\left$, by a gluon to the medium per gluon mean free path, $\\lambda_{\\rm mfp}$. In the original BDMPSZ formalism, the energy loss of an outgoing parton, $-dE/dx$, per unit length ($x$) of a medium with total length $L$, due to coherent gluon bremsstrahlung, is proportional to the $\\left$ and takes the form: ${-dE/dx }\\simeq \\alpha_s \\left=\\alpha_s\\, \\mu^2\\, L/\\lambda_{\\rm mfp} =\\alpha_s\\, \\hat{q}\\, L\\ $ , where $\\mu$, is the mean momentum transfer per collision. Thus, the total energy loss in the medium goes like $L^2$. Additionally, the accumulated momentum$^2$, $\\left$, transverse to a gluon traversing a length $L$ in the medium is well approximated by $\\left\\approx\\left=\\hat{q}\\, L$. A simple estimate shows that the $\\left\\approx\\hat{q}\\,L$ should be observable at RHIC at ...

  9. Warm Spitzer and Palomar Near-IR Secondary Eclipse Photometry of Two Hot Jupiters: WASP-48b and HAT-P-23b

    CERN Document Server

    O'Rourke, Joseph G; Zhao, Ming; Fortney, Jonathan J; Burrows, Adam; Agol, Eric; Deming, Drake; Desert, Jean-Michel; Howard, Andrew W; Lewis, Nikole K; Showman, Adam P; Todorov, Kamen O

    2013-01-01

    We report secondary eclipse photometry of two hot Jupiters, WASP-48b and HAT-P-23b, at 3.6 and 4.5 um taken with the InfraRed Array Camera aboard the Spitzer Space Telescope during the warm Spitzer mission and in the H and Ks bands with the Wide Field IR Camera at the Palomar 200-inch Hale Telescope. WASP-48b and HAT-P-23b are Jupiter-mass and twice Jupiter-mass objects orbiting an old, slightly evolved F star and an early G dwarf star, respectively. In the H, Ks, 3.6 um, and 4.5 um bands, respectively, we measure secondary eclipse depths of 0.047% +/- 0.016%, 0.109% +/- 0.027%, 0.176% +/- 0.013%, and 0.214% +/- 0.020% for WASP-48b. In the Ks, 3.6 um, and 4.5 um bands, respectively, we measure secondary eclipse depths of 0.234% +/- 0.046%, 0.248% +/- 0.019%, and 0.309% +/- 0.026% for HAT-P-23b. For WASP-48b and HAT-P-23b, respectively, we measure delays of 2.6 +/- 3.9 minutes and 4.0 +/- 2.4 minutes relative to the predicted times of secondary eclipse for circular orbits, placing 2-sigma upper limits on |e co...

  10. High Efficiency White Fluorescent Organic Light-Emitting Diodes with HAT-CN Hole Injection Layer%HAT-CN作为空穴注入层的高效白色荧光有机电致发光二极管

    Institute of Scientific and Technical Information of China (English)

    张静; 张方辉; 阎洪刚

    2011-01-01

    This paper investigated a high efficiency stacked white fluorescent organic lightemitting diodes consisting of separate blue and yellow elements with a 1,4,5,8,9,11-hexaazatriphenylene-hexacar bonitril (HAT-CN) hole injection layer.The configurations of the devices are ITO/2-TNATA or HAT-CN(x nm)/NPB (25 nm)/ADN (30 nm):TBPE (2%):DCJTB(1%)/Alq3(20 nm)/LiF (1 nm)/Al (100 nm).According to the experimental result,the effect of HAT-CN film on carrier injection and color purity were significant.This work obtained a higher efficiency and color purity for the WOLED with HAT-CN layer,as compared to the conventional devices with copper phthalocyanine (CuPc) or 2-TNATA materials as a hole injection layer.It shows pure-white light emitting with 1931 CIE chromaticity coordinates x=0.3309,y=0.3472,and a current efficiency of 6.4 cd/A.%制作了HAT-CN作为空穴注入层的蓝、黄二基色分离的堆叠式高效有机发光二极管,器件结构为:ITO/2-TNATA或HAT-CN(x nm)/NPB(25 nm)/ADN(30 nm):TBPE (2%):DCJTB (1%)/Alq3 (20nm)/LiF(1 nm)/Al(100 nm).实验结果表明,HAT-CN对载流子的注入和色纯度的影响很明显.相比于传统器件将CuPc和2-TNATA作为空穴注入层,HAT-CN作为空穴注入层得到了更高的效率和色纯度,CIE 色坐标x=0.3309,y=0.3472,电流效率达到6.4 cd/A.

  11. 3.6 and 4.5 μm Spitzer Phase Curves of the Highly Irradiated Hot Jupiters WASP-19b and HAT-P-7b

    Science.gov (United States)

    Wong, Ian; Knutson, Heather A.; Kataria, Tiffany; Lewis, Nikole K.; Burrows, Adam; Fortney, Jonathan J.; Schwartz, Joel; Shporer, Avi; Agol, Eric; Cowan, Nicolas B.; Deming, Drake; Désert, Jean-Michel; Fulton, Benjamin J.; Howard, Andrew W.; Langton, Jonathan; Laughlin, Gregory; Showman, Adam P.; Todorov, Kamen

    2016-06-01

    We analyze full-orbit phase curve observations of the transiting hot Jupiters WASP-19b and HAT-P-7b at 3.6 and 4.5 μm, obtained using the Spitzer Space Telescope. For WASP-19b, we measure secondary eclipse depths of 0.485%+/- 0.024% and 0.584%+/- 0.029% at 3.6 and 4.5 μm, which are consistent with a single blackbody with effective temperature 2372 ± 60 K. The measured 3.6 and 4.5 μm secondary eclipse depths for HAT-P-7b are 0.156%+/- 0.009% and 0.190%+/- 0.006%, which are well described by a single blackbody with effective temperature 2667 ± 57 K. Comparing the phase curves to the predictions of one-dimensional and three-dimensional atmospheric models, we find that WASP-19b’s dayside emission is consistent with a model atmosphere with no dayside thermal inversion and moderately efficient day-night circulation. We also detect an eastward-shifted hotspot, which suggests the presence of a superrotating equatorial jet. In contrast, HAT-P-7b’s dayside emission suggests a dayside thermal inversion and relatively inefficient day-night circulation; no hotspot shift is detected. For both planets, these same models do not agree with the measured nightside emission. The discrepancies in the model-data comparisons for WASP-19b might be explained by high-altitude silicate clouds on the nightside and/or high atmospheric metallicity, while the very low 3.6 μm nightside planetary brightness for HAT-P-7b may be indicative of an enhanced global C/O ratio. We compute Bond albedos of 0.38 ± 0.06 and 0 (\\lt 0.08 at 1σ ) for WASP-19b and HAT-P-7b, respectively. In the context of other planets with thermal phase curve measurements, we show that WASP-19b and HAT-P-7b fit the general trend of decreasing day-night heat recirculation with increasing irradiation.

  12. Phase II, Title I engineering assessment of inactive uranium mill tailings, Mexican Hat site, Mexican Hat, Utah. [Environmental effects, health hazards, and options for stabilization of tailings and fencing or decontamination of sites

    Energy Technology Data Exchange (ETDEWEB)

    None

    1977-03-31

    An engineering assessment of the problems resulting from the existence of radioactive uranium mill tailings at the Mexican Hat millsite in Utah is presented. Topographic maps, data on core drillings and radiometric measurements sufficient to determine areas and volumes of tailings and other radium-contaminated materials, the evaluation of resulting radiation exposures of individuals residing nearby, the investigation of site hydrology and meteorology, and the evaluation and costing of alternative corrective actions are presented. Radon gas release from the 2,200,000 tons of tailings on the site constitutes the most significant environmental impact. T he six alternative actions presented are directed towards restricting access to the site, returning the windblown tailings to the piles and stabilizing the piles with cover material, and consolidating the two piles into one pile and stabilizing it with cover material. Fencing around the site or the tailings and the decontamination of mill buildings is included in all options. Costs of the options range from $370,000 to $4,390,000.

  13. Comparative analysis of the recently discovered hAT transposon TcBuster in human cells.

    Directory of Open Access Journals (Sweden)

    Lauren E Woodard

    Full Text Available BACKGROUND: Transposons are useful tools for creating transgenic organisms, insertional mutagenesis, and genome engineering. TcBuster, a novel hAT-family transposon system derived from the red flour beetle Tribolium castaneum, was shown to be highly active in previous studies in insect embryoes. METHODOLOGY/PRINCIPAL FINDINGS: We tested TcBuster for its activity in human embryonic kidney 293 (HEK-293 cells. Excision footprints obtained from HEK-293 cells contained small insertions and deletions consistent with a hAT-type repair mechanism of hairpin formation and non-homologous end-joining. Genome-wide analysis of 23,417 piggyBac, 30,303 Sleeping Beauty, and 27,985 TcBuster integrations in HEK-293 cells revealed a uniquely different integration pattern when compared to other transposon systems with regards to genomic elements. TcBuster experimental conditions were optimized to assay TcBuster activity in HEK-293 cells by colony assay selection for a neomycin-containing transposon. Increasing transposon plasmid increased the number of colonies, whereas gene transfer activity dependent on codon-optimized transposase plasmid peaked at 100 ng with decreased colonies at the highest doses of transposase DNA. Expression of the related human proteins Buster1, Buster3, and SCAND3 in HEK-293 cells did not result in genomic integration of the TcBuster transposon. TcBuster, Tol2, and piggyBac were compared directly at different ratios of transposon to transposase and found to be approximately comparable while having their own ratio preferences. CONCLUSIONS/SIGNIFICANCE: TcBuster was found to be highly active in mammalian HEK-293 cells and represents a promising tool for mammalian genome engineering.

  14. Comparative Analysis of the Recently Discovered hAT Transposon TcBuster in Human Cells

    Science.gov (United States)

    Woodard, Lauren E.; Li, Xianghong; Malani, Nirav; Kaja, Aparna; Hice, Robert H.; Atkinson, Peter W.; Bushman, Frederic D.; Craig, Nancy L.; Wilson, Matthew H.

    2012-01-01

    Background Transposons are useful tools for creating transgenic organisms, insertional mutagenesis, and genome engineering. TcBuster, a novel hAT-family transposon system derived from the red flour beetle Tribolium castaneum, was shown to be highly active in previous studies in insect embryoes. Methodology/Principal Findings We tested TcBuster for its activity in human embryonic kidney 293 (HEK-293) cells. Excision footprints obtained from HEK-293 cells contained small insertions and deletions consistent with a hAT-type repair mechanism of hairpin formation and non-homologous end-joining. Genome-wide analysis of 23,417 piggyBac, 30,303 Sleeping Beauty, and 27,985 TcBuster integrations in HEK-293 cells revealed a uniquely different integration pattern when compared to other transposon systems with regards to genomic elements. TcBuster experimental conditions were optimized to assay TcBuster activity in HEK-293 cells by colony assay selection for a neomycin-containing transposon. Increasing transposon plasmid increased the number of colonies, whereas gene transfer activity dependent on codon-optimized transposase plasmid peaked at 100 ng with decreased colonies at the highest doses of transposase DNA. Expression of the related human proteins Buster1, Buster3, and SCAND3 in HEK-293 cells did not result in genomic integration of the TcBuster transposon. TcBuster, Tol2, and piggyBac were compared directly at different ratios of transposon to transposase and found to be approximately comparable while having their own ratio preferences. Conclusions/Significance TcBuster was found to be highly active in mammalian HEK-293 cells and represents a promising tool for mammalian genome engineering. PMID:23166581

  15. A computational method for solving stochastic Itô–Volterra integral equations based on stochastic operational matrix for generalized hat basis functions

    Energy Technology Data Exchange (ETDEWEB)

    Heydari, M.H., E-mail: heydari@stu.yazd.ac.ir [Faculty of Mathematics, Yazd University, Yazd (Iran, Islamic Republic of); The Laboratory of Quantum Information Processing, Yazd University, Yazd (Iran, Islamic Republic of); Hooshmandasl, M.R., E-mail: hooshmandasl@yazd.ac.ir [Faculty of Mathematics, Yazd University, Yazd (Iran, Islamic Republic of); The Laboratory of Quantum Information Processing, Yazd University, Yazd (Iran, Islamic Republic of); Maalek Ghaini, F.M., E-mail: maalek@yazd.ac.ir [Faculty of Mathematics, Yazd University, Yazd (Iran, Islamic Republic of); The Laboratory of Quantum Information Processing, Yazd University, Yazd (Iran, Islamic Republic of); Cattani, C., E-mail: ccattani@unisa.it [Department of Mathematics, University of Salerno, Fisciano (Italy)

    2014-08-01

    In this paper, a new computational method based on the generalized hat basis functions is proposed for solving stochastic Itô–Volterra integral equations. In this way, a new stochastic operational matrix for generalized hat functions on the finite interval [0,T] is obtained. By using these basis functions and their stochastic operational matrix, such problems can be transformed into linear lower triangular systems of algebraic equations which can be directly solved by forward substitution. Also, the rate of convergence of the proposed method is considered and it has been shown that it is O(1/(n{sup 2}) ). Further, in order to show the accuracy and reliability of the proposed method, the new approach is compared with the block pulse functions method by some examples. The obtained results reveal that the proposed method is more accurate and efficient in comparison with the block pule functions method.

  16. HAT-P-57b: A Short-period Giant Planet Transiting a Bright Rapidly Rotating A8V Star Confirmed Via Doppler Tomography

    Science.gov (United States)

    Hartman, J. D.; Bakos, G. Á.; Buchhave, L. A.; Torres, G.; Latham, D. W.; Kovács, G.; Bhatti, W.; Csubry, Z.; de Val-Borro, M.; Penev, K.; Huang, C. X.; Béky, B.; Bieryla, A.; Quinn, S. N.; Howard, A. W.; Marcy, G. W.; Johnson, J. A.; Isaacson, H.; Fischer, D. A.; Noyes, R. W.; Falco, E.; Esquerdo, G. A.; Knox, R. P.; Hinz, P.; Lázár, J.; Papp, I.; Sári, P.

    2015-12-01

    We present the discovery of HAT-P-57b, a P = 2.4653 day transiting planet around a V=10.465+/- 0.029 mag, {T}{{eff}}=7500+/- 250 K main sequence A8V star with a projected rotation velocity of v{sin}i=102.1+/- 1.3 {km} {{{s}}}-1. We measure the radius of the planet to be R=1.413+/- 0.054 {R}{{J}} and, based on RV observations, place a 95% confidence upper limit on its mass of M\\lt 1.85 {M}{{J}}. Based on theoretical stellar evolution models, the host star has a mass and radius of 1.47+/- 0.12 {M}⊙ and 1.500+/- 0.050 {R}⊙ , respectively. Spectroscopic observations made with Keck-I/HIRES during a partial transit event show the Doppler shadow of HAT-P-57b moving across the average spectral line profile of HAT-P-57, confirming the object as a planetary system. We use these observations, together with analytic formulae that we derive for the line profile distortions, to determine the projected angle between the spin axis of HAT-P-57 and the orbital axis of HAT-P-57b. The data permit two possible solutions, with -16\\buildrel{\\circ}\\over{.} 7\\lt λ \\lt 3\\buildrel{\\circ}\\over{.} 3 or 27\\buildrel{\\circ}\\over{.} 6\\lt λ \\lt 57\\buildrel{\\circ}\\over{.} 4 at 95% confidence, and with relative probabilities for the two modes of 26% and 74%, respectively. Adaptive optics imaging with MMT/Clio2 reveals an object located 2\\buildrel{\\prime\\prime}\\over{.} 7 from HAT-P-57 consisting of two point sources separated in turn from each other by 0\\buildrel{\\prime\\prime}\\over{.} 22. The H- and {L}\\prime -band magnitudes of the companion stars are consistent with their being physically associated with HAT-P-57, in which case they are stars of mass 0.61+/- 0.10 {M}⊙ and 0.53+/- 0.08 {M}⊙ . HAT-P-57 is the most rapidly rotating star, and only the fourth main sequence A star, known to host a transiting planet. Based on observations obtained with the Hungarian-made Automated Telescope Network. Based in part on observations made with the Keck-I telescope at Mauna

  17. New ${\\cal W}_{q,p}(sl(2))$ algebras from the elliptic algebra ${\\cal A}_{q,p}({\\hat sl}(2)_c)$

    CERN Document Server

    Avan, J; Rossi, M; Sorba, Paul

    1997-01-01

    We construct operators t(z) in the elliptic algebra introduced by Foda et al. ${\\cal A}_{q,p}({\\hat sl}(2)_c)$. They close an exchange algebra when p^m=q^{c+2} for m integer. In addition they commute when p=q^{2k} for k integer non-zero, and they belong to the center of ${\\cal A}_{q,p}({\\hat sl}(2)_c)$ when k is odd. The Poisson structures obtained for t(z) in these classical limits are identical to the q-deformed Virasoro Poisson algebra, characterizing the exchange algebras at generic values of p, q and m as new ${\\cal W}_{q,p}(sl(2))$ algebras.

  18. The HAT-P-13 Exoplanetary System: Evidence for Spin-Orbit Alignment and a Third Companion

    CERN Document Server

    Winn, Joshua N; Howard, Andrew W; Marcy, Geoffrey W; Bakos, Gaspar A; Hartman, Joel; Torres, Guillermo; Albrecht, Simon; Narita, Norio

    2010-01-01

    We present new radial-velocity measurements of HAT-P-13, a star with two previously known companions: a transiting giant planet "b" with an orbital period of 3 days, and a more massive object "c" on a 1.2 yr, highly eccentric orbit. For this system, dynamical considerations would lead to constraints on planet b's interior structure, if it could be shown that the orbits are coplanar and apsidally locked. By modeling the Rossiter-McLaughlin effect, we show that planet b's orbital angular momentum vector and the stellar spin vector are well-aligned on the sky (lambda = -0.9 +/- 8.5 deg), suggesting that the planetary orbits are also well-aligned. The refined orbital solution favors a slightly eccentric orbit for planet b (e = 0.0142_{-0.0044}^{+0.0052}), although it is not clear whether it is apsidally locked with c's orbit (\\Delta\\omega = 48_{-38}^{+25} deg). We find a long-term trend in the star's radial velocity and interpret it as evidence for an additional body "d", which may be another planet or a low-mass...

  19. A Case Study on a Strong Tropical Disturbance and Record Heavy Rainfall in Hat Yai, Thailand during the Winter Monsoon

    Institute of Scientific and Technical Information of China (English)

    Angkool WANGWONGCHAI; ZHAO Sixiong; ZENG Qingcun

    2005-01-01

    The evolutionary process and structural characteristics of the atmospheric circulation and synoptic situation which caused the record heavy rainfall with a precipitation amount of 550 mm in Hat Yai,Thailand from 20 to 23 November 2000 is studied. In the study, the modern three dimensional observational data were collected as completely as possible, and detailed analyses were made. It is revealed that the cold surges of the Asian winter monsoon that originate from Siberia can arrive at the lower latitudes, including South Thailand, Malaysia, Indonesia, cause strong heavy rainfall there, and interact with weather systems in the near-equatorial regions of the Southern Hemisphere. This is strongly supported by Chinese scientist's original finding in 1930s. The strong convective cloud clusters in the above areas are generated by the direct influence of the cold surges, and are related with the South China Sea disturbances in the lower troposphere. The maximum of the convergence of total moisture flux near South Thailand in the situation under study implies that the water vapour supply is abundant and very favorable to the occurrence of the heavy rainfall. The release of latent heat enhances the Hadley Circulation also. The feedback of the strong severe weather on climate indeed exists, and there are pronounced interactions between the multi-scale systems and between both hemispheres.

  20. A case study on a strong tropical disturbance and record heavy rainfall in Hat Yai, Thailand during the winter monsoon

    Science.gov (United States)

    Wangwongchai, Angkool; Zhao, Sixiong; Zeng, Qingcun

    2005-06-01

    The evolutionary process and structural characteristics of the atmospheric circulation and synoptic situation which caused the record heavy rainfall with a precipitation amount of 550 mm in Hat Yai, Thailand from 20 to 23 November 2000 is studied. In the study, the modern three dimensional observational data were collected as completely as possible, and detailed analyses were made. It is revealed that the cold surges of the Asian winter monsoon that originate from Siberia can arrive at the lower latitudes, including South Thailand, Malaysia, Indonesia, cause strong heavy rainfall there, and interact with weather systems in the near-equatorial regions of the Southern Hemisphere. This is strongly supported by Chinese scientist’s original finding in 1930s. The strong convective cloud clusters in the above areas are generated by the direct influence of the cold surges, and are related with the South China Sea disturbances in the lower troposphere. The maximum of the convergence of total moisture flux near South Thailand in the situation under study implies that the water vapour supply is abundant and very favorable to the occurrence of the heavy rainfall. The release of latent heat enhances the Hadley Circulation also. The feedback of the strong severe weather on climate indeed exists, and there are pronounced interactions between the multi-scale systems and between both hemispheres.

  1. The effects of angiotensinogen gene polymorphisms on cardiovascular disease outcomes during antihypertensive treatment in the GenHAT study

    Directory of Open Access Journals (Sweden)

    Anh N. Do

    2014-09-01

    Full Text Available Previous studies have reported that risk of cardiovascular morbidity and mortality substantially increases in hypertensive patients, especially among those with inadequate blood pressure control. Two common antihypertensive drug classes including thiazide diuretics and angiotensinogen converting enzyme (ACE inhibitors affect different enzymes in the renin angiotensinogen aldosterone system (RAAS. In the RAAS, angiotensinogen is converted into angiotensin II which increases blood pressure through vasoconstriction. Using a case-only design with 3,448 high-risk hypertensive individuals from the Genetics of Hypertension Associated Treatment (GenHAT study, we examined whether 7 single nucleotide polymorphisms (SNPs in the angiotensinogen gene (AGT interact with three classes of antihypertensive drugs including chlorthalidone (a thiazide diuretic, lisinopril (an ACE inhibitor, and amlodipine (a calcium channel blocker to modify the risk of incident coronary heart disease (CHD and heart failure (HF among Caucasian and African American participants, separately. We found no gene by treatment interactions to be statistically significant after correction for multiple testing. However, some suggestive results were found. African American participants with the minor allele of rs11122576 had over two-fold higher risk of CHD when using chlorthalidone compared to using amlodipine, or lisinopril compared to amlodipine (p=0.006, and p=0.01, respectively. Other marginal associations are also reported among both race groups. The findings reported here suggest that rs11122576 could contribute to future personalization of antihypertensive treatment among African Americans though more studies are needed.

  2. GTC OSIRIS transiting exoplanet atmospheric survey: detection of potassium in HAT-P-1b from narrowband spectrophotometry

    CERN Document Server

    Wilson, P A; Nikolov, N; Etangs, A Lecavelier des; Pont, F; Fortney, J J; Ballester, G E; López-Morales, M; Désert, J -M; Vidal-Madjar, A

    2015-01-01

    We present the detection of potassium in the atmosphere of HAT-P-1b using optical transit narrowband photometry. The results are obtained using the 10.4 m Gran Telescopio Canarias (GTC) together with the OSIRIS instrument in tunable filter imaging mode. We observed four transits, two at continuum wavelengths outside the potassium feature, at 6792 {\\AA} and 8844 {\\AA}, and two probing the potassium feature in the line wing at 7582.0 {\\AA} and the line core at 7664.9 {\\AA} using a 12 {\\AA} filter width (R~650). The planet-to-star radius ratios in the continuum are found to be $R_{\\rm{pl}}/R_{\\star}$ = 0.1176 $\\pm$ 0.0013 at 6792 {\\AA} and $R_{\\rm{pl}}/R_{\\star}$ = 0.1168 $\\pm$ 0.0022 at 8844 {\\AA}, significantly lower than the two observations in the potassium line: $R_{\\rm{pl}}/R_{\\star}$ = 0.1248 $\\pm$ 0.0014 in the line wing at 7582.0 {\\AA} and $R_{\\rm{pl}}/R_{\\star}$ = 0.1268 $\\pm$ 0.0012 in the line core at 7664.9 {\\AA}. With a weighted mean of the observations outside the potassium feature $R_{\\rm{pl}}/R_...

  3. Remedial Action Plan and site design for stabilization of the inactive uranium mill tailings site at Mexican Hat, Utah: Appendix D. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-07-01

    This appendix is an assessment of the present conditions of the inactive uranium mill site near Mexican Hat, Utah. It consolidates available engineering, radiological, geotechnical, hydrological, meteorological, and other information pertinent to the design of the Remedial Action Plan. Plan is to characterize the conditions at the mill and tailings site so that the Remedial Action Contractor may complete final designs of the remedial action.

  4. HATS-6b: A Warm Saturn Transiting an Early M Dwarf Star, and a Set of Empirical Relations for Characterizing K and M Dwarf Planet Hosts

    CERN Document Server

    Hartman, J D; Brahm, R; Bakos, G Á; Mancini, L; Jordán, A; Penev, K; Rabus, M; Zhou, G; Butler, R P; Espinoza, N; de Val-Borro, M; Bhatti, W; Csubry, Z; Ciceri, S; Henning, T; Schmidt, B; Arriagada, P; Shectman, S; Crane, J; Thompson, I; Suc, V; Csák, B; Tan, T G; Noyes, R W; Lázár, J; Papp, I; Sári, P

    2014-01-01

    We report the discovery by the HATSouth survey of HATS-6b, an extrasolar planet transiting a V=15.2 mag, i=13.7 mag M1V star with a mass of 0.57 Msun and a radius of 0.57 Rsun. HATS-6b has a period of P = 3.3253 d, mass of Mp=0.32 Mjup, radius of Rp=1.00 Rjup, and zero-albedo equilibrium temperature of Teq=712.8+-5.1 K. HATS-6 is one of the lowest mass stars known to host a close-in gas giant planet, and its transits are among the deepest of any known transiting planet system. We discuss the follow-up opportunities afforded by this system, noting that despite the faintness of the host star, it is expected to have the highest K-band S/N transmission spectrum among known gas giant planets with Teq < 750 K. In order to characterize the star we present a new set of empirical relations between the density, radius, mass, bolometric magnitude, and V, J, H and K-band bolometric corrections for main sequence stars with M < 0.80 Msun, or spectral types later than K5. These relations are calibrated using eclipsing...

  5. The application of the Mid-IR radio correlation to the $\\hat{G}$ sample and the search for advanced extraterrestrial civilisations

    CERN Document Server

    Garrett, Michael

    2015-01-01

    Wright et al. 2014 have embarked on a search for advanced Karadashev Type III civilisations via the compilation of a sample of sources with extreme mid-IR emission and colours. In this scenario, the mid-IR emission is then primarily associated with waste heat energy by-products. I apply the Mid-IR radio correlation to this $\\hat{G}$ sample (Griffith et al. 2015). I demonstrate that the mid-IR and radio luminosities are correlated for the sample with $q_{22}=1.35\\pm0.42 $. By comparison, the First Look Survey (FLS) has $q_{22}=0.87\\pm0.27$. The fact that the G-HAT sample largely follows the Mid-IR radio correlation, strongly suggests the vast majority of these sources are associated with galaxies in which natural astrophysical processes are dominant. This simple application of the mid-IR radio correlation can substantially reduce the number of false positives in the $\\hat{G}$ catalogue, since galaxies occupied by advanced Kardashev Type III civilisations would be expected to exhibit very high values of $q$. In...

  6. Transmission spectroscopy of HAT-P-32b with the LBT: confirmation of clouds/hazes in the planetary atmosphere

    Science.gov (United States)

    Mallonn, M.; Strassmeier, K. G.

    2016-05-01

    Aims: Spectroscopic observations of a transit event of an extrasolar planet offer the opportunity to study the composition of the planetary atmosphere. This can be done with comparably little telescope time using a low-resolution multi-object spectrograph at a large aperture telescope. We observed a transit of the inflated hot Jupiter HAT-P-32b with the Multi-Object Double Spectrograph at the Large Binocular Telescope to characterize its atmosphere from 3300 to 10 000 Å. Methods: A time series of target and reference star spectra was binned in two broad-band wavelength channels, from which differential transit light curves were constructed. These broad-band light curves were used to confirm previous transit parameter determinations. To derive the planetary transmission spectrum with a resolution of R ~ 60, we created a chromatic set of 62 narrow-band light curves. The spectrum was corrected for the third light of a nearby M star. Additionally, we undertook a photometric monitoring campaign of the host star to correct for the influence of starspots. Results: The transmission spectrum of HAT-P-32b shows no pressure-broadened absorption features from Na and K, which is interpreted by the presence of clouds or hazes in the planetary atmosphere. This result is in agreement with previous studies on the same planet. The presence of TiO in gas phase could be ruled out. We find a 2.8σ indication of increased absorption in the line core of potassium (K I 7699 Å). No narrow absorption features of Na and Hα were detected. Furthermore, tentative indications were found for a slope of increasing opacity toward blue wavelengths from the near-IR to the near-UV with an amplitude of two scale heights. If confirmed by follow-up observations, it can be explained by aerosols either causing Mie scattering or causing Rayleigh scattering with an aerosol - gas scale height ratio below unity. The host star was found to be photometrically stable within the measurement precision. Based on

  7. 什么是公民教育%W hat is the Civic Education

    Institute of Scientific and Technical Information of China (English)

    韩益凤

    2014-01-01

    In practice , the civic education w hich is to cultivate citizens , bring up citizenship , and to shape civic virtues will be affected by the changes of some related concepts as citizens 、citizenship and so on . At the same time , the civic education as a kind of special educational activity , naturally , will change with the development of the education thoughts and ideas . On the one hand ,civic education is just a way to make good citizens ;on the other hand , civic education is just one aspect of education functions . However ,in any case , citizens are not only need to be educated , but also can be educated . So the ultimate ideal of the civic education inevitably point to the human good life .%实践中,以培养公民、造就公民身份、塑造公民道德为指向的公民教育不可避免地会受到公民、公民身份等相关概念内涵变化的影响。同时,公民教育作为一种特殊的教育活动,自然也会伴随教育思想、教育理念的发展变化而变化。一方面公民教育只是造就公民的一种途径,另一方面公民教育也只是教育功能的一个方面。不过,无论如何,公民都不但需要教育,而且可以教育。公民教育的终极理想必然指向人类的善好生活。

  8. Classification of Ultra-High Resolution Orthophotos Combined with DSM Using a Dual Morphological Top Hat Profile

    Directory of Open Access Journals (Sweden)

    Qian Zhang

    2015-12-01

    Full Text Available New aerial sensors and platforms (e.g., unmanned aerial vehicles (UAVs are capable of providing ultra-high resolution remote sensing data (less than a 30-cm ground sampling distance (GSD. This type of data is an important source for interpreting sub-building level objects; however, it has not yet been explored. The large-scale differences of urban objects, the high spectral variability and the large perspective effect bring difficulties to the design of descriptive features. Therefore, features representing the spatial information of the objects are essential for dealing with the spectral ambiguity. In this paper, we proposed a dual morphology top-hat profile (DMTHP using both morphology reconstruction and erosion with different granularities. Due to the high dimensional feature space, we have proposed an adaptive scale selection procedure to reduce the feature dimension according to the training samples. The DMTHP is extracted from both images and Digital Surface Models (DSM to obtain complimentary information. The random forest classifier is used to classify the features hierarchically. Quantitative experimental results on aerial images with 9-cm and UAV images with 5-cm GSD are performed. Under our experiments, improvements of 10% and 2% in overall accuracy are obtained in comparison with the well-known differential morphological profile (DMP feature, and superior performance is observed over other tested features. Large format data with 20,000 × 20,000 pixels are used to perform a qualitative experiment using the proposed method, which shows its promising potential. The experiments also demonstrate that the DSM information has greatly enhanced the classification accuracy. In the best case in our experiment, it gives rise to a classification accuracy from 63.93% (spectral information only to 94.48% (the proposed method.

  9. THE STELLAR OBLIQUITY AND THE LONG-PERIOD PLANET IN THE HAT-P-17 EXOPLANETARY SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Fulton, Benjamin J.; Howard, Andrew W. [Institute for Astronomy, University of Hawaii at Manoa, 2680 Woodlawn Dr, Honolulu, HI 96822 (United States); Winn, Joshua N.; Albrecht, Simon [Department of Physics and Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Marcy, Geoffrey W.; Isaacson, Howard [University of California, Berkeley, Berkeley, CA (United States); Crepp, Justin R. [University of Notre Dame, Department of Physics, Notre Dame, IN (United States); Bakos, Gaspar A.; Hartman, Joel D. [Princeton University, Department of Astrophysical Sciences, Princeton, NJ (United States); Johnson, John Asher; Knutson, Heather A. [California Institute of Technology, Pasadena, CA (United States); Zhao Ming [Department of Astronomy and Astrophysics, 525 Davey Laboratory, Pennsylvania State University, University Park, PA 16802 (United States)

    2013-08-01

    We present the measured projected obliquity-the sky-projected angle between the stellar spin axis and orbital angular momentum-of the inner planet of the HAT-P-17 multi-planet system. We measure the sky-projected obliquity of the star to be {lambda}=19{sup +14}{sub -16} deg by modeling the Rossiter-McLaughlin effect in Keck/HIRES radial velocities (RVs). The anomalous RV time series shows an asymmetry relative to the midtransit time, ordinarily suggesting a nonzero obliquity-but in this case at least part of the asymmetry may be due to the convective blueshift, increasing the uncertainty in the determination of {lambda}. We employ the semi-analytical approach of Hirano et al. that includes the effects of macroturbulence, instrumental broadening, and convective blueshift to accurately model the anomaly in the net RV caused by the planet eclipsing part of the rotating star. Obliquity measurements are an important tool for testing theories of planet formation and migration. To date, the measured obliquities of {approx}50 Jovian planets span the full range, from prograde to retrograde, with planets orbiting cool stars preferentially showing alignment of stellar spins and planetary orbits. Our results are consistent with this pattern emerging from tidal interactions in the convective envelopes of cool stars and close-in planets. In addition, our 1.8 yr of new RVs for this system show that the orbit of the outer planet is more poorly constrained than previously thought, with an orbital period now in the range of 10-36 yr.

  10. Wave-turbulence description of interacting particles: Klein-Gordon model with a Mexican-hat potential.

    Science.gov (United States)

    Gallet, Basile; Nazarenko, Sergey; Dubrulle, Bérengère

    2015-07-01

    In field theory, particles are waves or excitations that propagate on the fundamental state. In experiments or cosmological models, one typically wants to compute the out-of-equilibrium evolution of a given initial distribution of such waves. Wave turbulence deals with out-of-equilibrium ensembles of weakly nonlinear waves, and is therefore well suited to address this problem. As an example, we consider the complex Klein-Gordon equation with a Mexican-hat potential. This simple equation displays two kinds of excitations around the fundamental state: massive particles and massless Goldstone bosons. The former are waves with a nonzero frequency for vanishing wave number, whereas the latter obey an acoustic dispersion relation. Using wave-turbulence theory, we derive wave kinetic equations that govern the coupled evolution of the spectra of massive and massless waves. We first consider the thermodynamic solutions to these equations and study the wave condensation transition, which is the classical equivalent of Bose-Einstein condensation. We then focus on nonlocal interactions in wave-number space: we study the decay of an ensemble of massive particles into massless ones. Under rather general conditions, these massless particles accumulate at low wave number. We study the dynamics of waves coexisting with such a strong condensate, and we compute rigorously a nonlocal Kolmogorov-Zakharov solution, where particles are transferred nonlocally to the condensate, while energy cascades towards large wave numbers through local interactions. This nonlocal cascading state constitutes the intermediate asymptotics between the initial distribution of waves and the thermodynamic state reached in the long-time limit.

  11. Wave-turbulence description of interacting particles: Klein-Gordon model with a Mexican-hat potential

    Science.gov (United States)

    Gallet, Basile; Nazarenko, Sergey; Dubrulle, Bérengère

    2015-07-01

    In field theory, particles are waves or excitations that propagate on the fundamental state. In experiments or cosmological models, one typically wants to compute the out-of-equilibrium evolution of a given initial distribution of such waves. Wave turbulence deals with out-of-equilibrium ensembles of weakly nonlinear waves, and is therefore well suited to address this problem. As an example, we consider the complex Klein-Gordon equation with a Mexican-hat potential. This simple equation displays two kinds of excitations around the fundamental state: massive particles and massless Goldstone bosons. The former are waves with a nonzero frequency for vanishing wave number, whereas the latter obey an acoustic dispersion relation. Using wave-turbulence theory, we derive wave kinetic equations that govern the coupled evolution of the spectra of massive and massless waves. We first consider the thermodynamic solutions to these equations and study the wave condensation transition, which is the classical equivalent of Bose-Einstein condensation. We then focus on nonlocal interactions in wave-number space: we study the decay of an ensemble of massive particles into massless ones. Under rather general conditions, these massless particles accumulate at low wave number. We study the dynamics of waves coexisting with such a strong condensate, and we compute rigorously a nonlocal Kolmogorov-Zakharov solution, where particles are transferred nonlocally to the condensate, while energy cascades towards large wave numbers through local interactions. This nonlocal cascading state constitutes the intermediate asymptotics between the initial distribution of waves and the thermodynamic state reached in the long-time limit.

  12. Micromamíferos del Pleistoceno Medio y Pleistoceno Superior en el Valle del Jarama: yacimientos de Valdocarros y HAT (Madrid, España

    Directory of Open Access Journals (Sweden)

    Sesé, C.

    2011-06-01

    Full Text Available We study the micromammals from the sites of Valdocarros and HAT, located in the lithostratigraphic unit of Arganda II and IV respectively, within the Arganda Complex Terrace, in the Jarama Valley (Madrid, Spain. The micromammal associations of these sites consist of the following taxa: in Valdocarros: Erinaceomorpha: Erinaceus europaeus; Soricomorpha: Crocidura aff. russula; Rodentia: Eliomys quercinus, Castor fiber, Apodemus sp., Cricetulus (Allocricetus bursae, Arvicola aff. sapidus and Microtus brecciensis; and Lagomorpha: Oryctolagus cuniculus; and in HAT: Soricomorpha: Soricidae indet.; Rodentia: Eliomys quercinus, Apodemus sp., Arvicola aff. sapidus and Microtus cf. cabrerae; and Lagomorpha: cf. Oryctolagus sp. The micromammal assemblage of the Valdocarros site can be placed in the advanced Middle Pleistocene, but not in its end, because of the faunal association and the evolved state of Microtus brecciensis. However, in HAT, the presence of Microtus cf. cabrerae suggests that this site belongs to the Late Pleistocene. Both micromammal assemblages indicate a temperate climate and a well developed vegetation cover, consisting of some forest and also open areas, with shrub-like vegetation and also meadow and riverside vegetation.

    Se realiza el estudio de los micromamíferos del yacimiento de Valdocarros, que se localiza en la uni dad de Arganda II de la Terraza Compleja de Arganda, en el valle del Jarama (Madrid, y del yacimiento de HAT, que está en la unidad de Arganda IV. Las asociaciones de micromamíferos determinadas en este trabajo en dichos yacimientos son las siguientes: en Valdocarros: erinaceomorfos: Erinaceus europaeus; soricomorfos: Crocidura aff. russula; roedores: Eliomys quercinus, Castor fiber, Apodemus sp., Cricetulus (Allocricetus bursae, Arvicola aff. sapidus y Microtus brecciensis; y lagomorfos:

  13. Affordable echelle spectroscopy of the eccentric HAT-P-2, WASP-14 and XO-3 planetary systems with a sub-meter-class telescope

    CERN Document Server

    Garai, Z; Hambálek, Ľ; Kundra, E; Vaňko, M; Raetz, S; Seeliger, M; Marka, C; Gilbert, H

    2016-01-01

    A new off-shelf low-cost echelle spectrograph was installed recently on the 0.6m telescope at the Star\\'a Lesn\\'a Observatory (Slovakia). In this paper we describe in details the radial velocity (RV) analysis of the first three transiting planetary systems, HAT-P-2, WASP-14 and XO-3, observed with this instrument. Furthermore, we compare our data with the RV data achieved with echelle spectrographs of other sub-meter-, meter- and two-meter-class telescopes in terms of their precision. Finally, we investigate the applicability of our RV data for modeling orbital parameters.

  14. 人β-珠蛋白核基质附着区介导表达载体稳定附着于中国仓鼠卵巢细胞%Expression vector mediated by human β-globin matrix attachment region functions as stable episomes in Chinese hamster ovary cells

    Institute of Scientific and Technical Information of China (English)

    吴向楠; 王天云; 杨瑞; 王俪; 王芳

    2013-01-01

    目的 研究人β-珠蛋白核基质附着区是否能够介导表达载体稳定附着于中国仓鼠卵巢(CHO)细胞.方法 人β-珠蛋白MAR序列克隆到pEGFP-C1构建重组质粒载体pEGFP-MAR,转染CHO细胞,使用Hirt裂解法提取细胞中附着体质粒,CaCI2法转化附着体质粒到宿主大肠杆菌DH5a中,提取质粒,酶切,测序分析.结果 还原质粒双酶切和单酶切结果均与转染前质粒酶切结果一致;测序分析得知还原质粒与转染前质粒中插入片段DNA序列相同.结论 人β-珠蛋白MAR序列重组载体在CHO细胞中以附着体形式被完整还原出来.还原质粒酶切结果和测序结果均与转染前质粒一致.%Objective To study the human β-globin matrix attachment region(MAR) sequence mediated vector whether exist as stable episomes in transfected Chinese hamster ovary(CHO) cells.Methods Recombinant plasmid vector pEGFPMAR was constructed by thrusting the amplified human β-globin MAR sequence into the parental pEGFP-C1.CHO cells were transfected both with pEGFP-C1 and reconstructed vector.Episomal vectors from the stable monoclonal cell lines were extracted by modificated Hirt cracking protocol.Then CaCl2 method was performed to transform episomal vectors into the host bacteria E.coli DH5α,and the plasmid from the transformed E.coli DH5α was extracted.In the end,enzyme digestion identification and sequencing analysis were performed to detect the rescued plasmid and the original plasmid.Results Both double enzyme and single enzyme to completely digested the rescued plasmids and the original plassmid showed the same result.The sequencing analysis showed that the inserted sequence of rescued plasmid was identical to the original DNA sequence.Conclusion Human β-globin MAR characteristic sequence-based vector can be completely rescued from cultured CHO cells.The results of enzyme digestion identification and sequencing analysis are consistent in the rescued plasmids and the original plasmid.

  15. Edebi Tür Olarak Mektup, Hatıra ve Günlüklere Yansıyanlar : Çanakkale’de Savaşan Askerlerin Mektup Hatıra ve Günlüklerinde Yer Alan Motivasyon Unsurları

    OpenAIRE

    Altunyay, Korhan

    2014-01-01

    Edebiyat bilimi mektup, hatıra ve günlük gibi edebi türleri hem edebi tür olarak hem de araştırma kaynağı olarak kullanır. Bu türler/kaynaklar, aynı zamanda psikolojik araştırmalarda da kullanılır. Mektup, hatıra veya günlük gibi edebi türler, onu yazanın bilinçaltını görmek, hayata, olaylara ve problemlere ne tür açılardan baktığını fark etmek için kullanılır. Mektup, günlük ve hatıralara davranış-tepki ilişkisi açısından bakıldığı vakit pek çok detaya rastlanabilir. Bu çalışmada...

  16. KEPLER'S OPTICAL SECONDARY ECLIPSE OF HAT-P-7b AND PROBABLE DETECTION OF PLANET-INDUCED STELLAR GRAVITY DARKENING

    Energy Technology Data Exchange (ETDEWEB)

    Morris, Brett M.; Deming, Drake [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States); Mandell, Avi M. [Goddard Center for Astrobiology, NASA' s Goddard Space Flight Center, Greenbelt, MD 20771 (United States)

    2013-02-20

    We present observations spanning 355 orbital phases of HAT-P-7 observed by Kepler from 2009 May to 2011 March (Q1-9). We find a shallower secondary eclipse depth than initially announced, consistent with a low optical albedo and detection of nearly exclusively thermal emission, without a reflected light component. We find an approximately 10 ppm perturbation to the average transit light curve near phase -0.02 that we attribute to a temperature decrease on the surface of the star, phased to the orbit of the planet. This cooler spot is consistent with planet-induced gravity darkening, slightly lagging the sub-planet position due to the finite response time of the stellar atmosphere. The brightness temperature of HAT-P-7b in the Kepler bandpass is T{sub B} = 2733 {+-} 21 K and the amplitude of the deviation in stellar surface temperature due to gravity darkening is approximately -0.18 K. The detection of the spot is not statistically unequivocal due its small amplitude, though additional Kepler observations should be able to verify the astrophysical nature of the anomaly.

  17. HAT-P-49b: A 1.7 $M_J$ Planet Transiting a Bright 1.5 $M_\\odot$ F-Star

    CERN Document Server

    Bieryla, A; Bakos, G A; Bhatti, W; Kovacs, G; Boisse, I; Latham, D W; Buchhave, L A; Csubry, Z; Penev, K; de Val-Borro, M; Beky, B; Falco, E; Torres, G; Noyes, R W; Berlind, P; Calkins, M C; Esquerdo, G A; Lazar, J; Papp, I; Sari, P

    2014-01-01

    We report the discovery of the transiting extrasolar planet HAT-P-49b. The planet transits the bright (V = 10.3) slightly evolved F-star HD 340099 with a mass of 1.54 M_S and a radius of 1.83 R_S. HAT-P-49b is orbiting one of the 25 brightest stars to host a transiting planet which makes this a favorable candidate for detailed follow-up. This system is an especially strong target for Rossiter-McLaughlin follow-up due to the fast rotation of the host star, 16 km/s. The planetary companion has a period of 2.6915 d, mass of 1.73 M_J and radius of 1.41 R_J. The planetary characteristics are consistent with that of a classical hot Jupiter but we note that this is the fourth most massive star to host a transiting planet with both M_p and R_p well determined.

  18. WASP-35b, WASP-48b and WASP-51b: Two new planets and an independent discovery of HAT-P-30b

    CERN Document Server

    Enoch, B; Barros, S C C; Brown, D J A; Cameron, A Collier; Faedi, F; Gillon, M; Hébrard, G; Lister, T A; Queloz, D; Santerne, A; Smalley, B; Street, R A; Triaud, A H M J; West, R G; Bouchy, F; Bento, J; Butters, O; Fossati, L; Haswell, C A; Hellier, C; Holmes, S; Jehen, E; Lendl, M; Maxted, P F L; McCormac, J; Miller, G R M; Moulds, V; Moutou, C; Norton, A J; Parley, N; Pepe, F; Pollacco, D; Segransan, D; Simpson, E; Skillen, I; Smith, A M S; Udry, S; Wheatley, P J

    2011-01-01

    We report the detection of WASP-35b, a planet transiting a metal-poor ([Fe/H] = -0.15) star in the Southern hemisphere, WASP-48b, an inflated planet which may have spun-up its slightly evolved host star of 1.75 R_sun in the Northern hemisphere, and the independent discovery of HAT-P-30b / WASP-51b, a new planet in the Northern hemisphere. Using WASP, RISE, FTS and TRAPPIST photometry, with CORALIE, SOPHIE and NOT spectroscopy, we determine that WASP-35b has a mass of 0.72 +/- 0.06 M_J and radius of 1.32 +/- 0.03 R_J, and orbits with a period of 3.16 days, WASP-48b has a mass of 0.98 +/- 0.09 M_J, radius of 1.67 +/- 0.08 R_J and orbits in 2.14 days, while WASP-51b, with an orbital period of 2.81 days, is found to have a mass of 0.76 +/- 0.05 M_J and radius of 1.42 +/- 0.04 R_J, agreeing with values of 0.71 +/- 0.03 M_J and 1.34 +/- 0.07 R_J reported for HAT-P-30b.

  19. H2: entanglement, probability density function, confined Kratzer oscillator, universal potential and (Mexican hat- or bell-type) potential energy curves

    CERN Document Server

    Van Hooydonk, G

    2011-01-01

    We review harmonic oscillator theory for closed, stable quantum systems. The H2 potential energy curve (PEC) of Mexican hat-type, calculated with a confined Kratzer oscillator, is better than the Rydberg-Klein-Rees (RKR) H2 PEC. Compared with QM, the theory of chemical bonding is simplified, since a confined Kratzer oscillator gives the long sought for universal function, once called the Holy Grail of Molecular Spectroscopy. This is validated with HF, I2, N2 and O2 PECs. We quantify the entanglement of spatially separated H2 quantum states, which gives a braid view. The equal probability for H2, originating either from HA+HB or HB+HA, is quantified with a Gauss probability density function. At the Bohr scale, confined harmonic oscillators behave properly at all extremes of bound two-nucleon quantum systems and are likely to be useful also at the nuclear scale.

  20. Broad-band spectrophotometry of the hot Jupiter HAT-P-12b from the near-UV to the near-IR

    Science.gov (United States)

    Mallonn, M.; Nascimbeni, V.; Weingrill, J.; von Essen, C.; Strassmeier, K. G.; Piotto, G.; Pagano, I.; Scandariato, G.; Csizmadia, Sz.; Herrero, E.; Sada, P. V.; Dhillon, V. S.; Marsh, T. R.; Künstler, A.; Bernt, I.; Granzer, T.

    2015-11-01

    Context. The detection of trends or gradients in the transmission spectrum of extrasolar planets is possible with observations at very low spectral resolution. Transit measurements of sufficient accuracy using selected broad-band filters allow for an initial characterization of the atmosphere of the planet. Aims: We want to investigate the atmosphere of the hot Jupiter HAT-P-12b for an increased absorption at the very blue wavelength regions caused by scattering. Furthermore, we aim for a refinement of the transit parameters and the orbital ephemeris. Methods: We obtained time series photometry of 20 transit events and analyzed them homogeneously, along with eight light curves obtained from the literature. In total, the light curves span a range from 0.35 to 1.25 microns. During two observing seasons over four months each, we monitored the host star to constrain the potential influence of starspots on the derived transit parameters. Results: We rule out the presence of a Rayleigh slope extending over the entire optical wavelength range, a flat spectrum is favored for HAT-P-12b with respect to a cloud-free atmosphere model spectrum. A potential cause of such gray absorption is the presence of a cloud layer at the probed latitudes. Furthermore, in this work we refine the transit parameters, the ephemeris and perform a TTV analysis in which we found no indication for an unseen companion. The host star showed a mild non-periodic variability of up to 1%. However, no stellar rotation period could be detected to high confidence.

  1. The Parameterization of Top-Hat Particle Sensors with Microchannel-Plate-Based Detection Systems and its Application to the Fast Plasma Investigation on NASA's Magnetospheric MultiScale Mission

    Science.gov (United States)

    Gershman, Daniel J.; Gliese, Ulrik; Dorelli, John C.; Avanov, Levon A.; Barrie, Alexander C.; Chornay, Dennis J.; MacDonald, Elizabeth A.; Holland, Matthew P.; Pollock, Craig J.

    2015-01-01

    The most common instrument for low energy plasmas consists of a top-hat electrostatic analyzer geometry coupled with a microchannel-plate (MCP)-based detection system. While the electrostatic optics for such sensors are readily simulated and parameterized during the laboratory calibration process, the detection system is often less well characterized. Furthermore, due to finite resources, for large sensor suites such as the Fast Plasma Investigation (FPI) on NASA's Magnetospheric Multiscale (MMS) mission, calibration data are increasingly sparse. Measurements must be interpolated and extrapolated to understand instrument behavior for untestable operating modes and yet sensor inter-calibration is critical to mission success. To characterize instruments from a minimal set of parameters we have developed the first comprehensive mathematical description of both sensor electrostatic optics and particle detection systems. We include effects of MCP efficiency, gain, scattering, capacitive crosstalk, and charge cloud spreading at the detector output. Our parameterization enables the interpolation and extrapolation of instrument response to all relevant particle energies, detector high voltage settings, and polar angles from a small set of calibration data. We apply this model to the 32 sensor heads in the Dual Electron Sensor (DES) and 32 sensor heads in the Dual Ion Sensor (DIS) instruments on the 4 MMS observatories and use least squares fitting of calibration data to extract all key instrument parameters. Parameters that will evolve in flight, namely MCP gain, will be determined daily through application of this model to specifically tailored in-flight calibration activities, providing a robust characterization of sensor suite performance throughout mission lifetime. Beyond FPI, our model provides a valuable framework for the simulation and evaluation of future detection system designs and can be used to maximize instrument understanding with minimal calibration

  2. Tectonic geomorphology and volcano-tectonic interaction in the eastern boundary of the Southern Cascades (Hat Creek Graben region, California, USA

    Directory of Open Access Journals (Sweden)

    Engielle Mae Raot-raot Paguican

    2016-07-01

    Full Text Available The eastern boundary of the Southern Cascades (Hat Creek Graben region, California, USA, is an extensively faulted volcanic corridor between the Cascade Range and Modoc Plateau. The east-west extending region is in the transition zone between the convergence and subduction of the Gorda Plate underneath the North American Plate; north-south shortening within the Klamath Mountain region; and transcurrent movement in the Walker Lane. We describe the geomorphological and tectonic features, their alignment and distribution, in order to understand the tectonic geomorphology and volcano-tectonic relationships. One outcome of the work is a more refined morpho-structural description that will affect future hazard assessment in the area.A database of volcanic centers and structures was created from interpretations of topographic models generated from satellite images. Volcanic centers in the region were classified by morphological type into cones, sub-cones, shields and massifs. A second classification by height separated the bigger and smaller edifices and revealed an evolutionary trend. Poisson Nearest Neighbor analysis shows that bigger volcanoes are spatially dispersed while smaller ones are clustered. Using volcano centroid locations, about 90 lineaments consisting of at least three centers within 6km of one another were found, revealing that preferential north-northwest directed pathways control the transport of magma from the source to the surface, consistent with the strikes of the major fault systems. Most of the volcano crater openings are perpendicular to the maximum horizontal stress, expected for extensional environments with dominant normal regional faults. These results imply that the extension of the Hat Creek Graben region and impingement of the Walker Lane is accommodated mostly by extensional faults and partly by the intrusions that formed the volcanoes. Early in the history of a volcano or volcano cluster, melt produced at depth in the

  3. Broad-band spectrophotometry of the hot Jupiter HAT-P-12b from the near-UV to the near-IR

    CERN Document Server

    Mallonn, M; Weingrill, J; von Essen, C; Strassmeier, K G; Piotto, G; Pagano, I; Scandariato, G; Csizmadia, Sz; Herrero, E; Sada, P V; Dhillon, V S; Marsh, T R; Künstler, A; Bernt, I; Granzer, T

    2015-01-01

    The detection of trends or gradients in the transmission spectrum of extrasolar planets is possible with observations at very low spectral resolution. Transit measurements of sufficient accuracy using selected broad-band filters allow for an initial characterization of the atmosphere of the planet. We obtained time series photometry of 20 transit events and analyzed them homogeneously, along with eight light curves obtained from the literature. In total, the light curves span a range from 0.35 to 1.25 microns. During two observing seasons over four months each, we monitored the host star to constrain the potential influence of starspots on the derived transit parameters. We rule out the presence of a Rayleigh slope extending over the entire optical wavelength range, a flat spectrum is favored for HAT-P-12b with respect to a cloud-free atmosphere model spectrum. A potential cause of such gray absorption is the presence of a cloud layer at the probed latitudes. Furthermore, in this work we refine the transit pa...

  4. Spitzer Secondary Eclipses of the Dense, Modestly-irradiated, Giant Exoplanet HAT-P-20b Using Pixel-Level Decorrelation

    CERN Document Server

    Deming, Drake; Kammer, Joshua; Fulton, Benjamin J; Ingalls, James; Carey, Sean; Burrows, Adam; Fortney, Jonathan J; Todorov, Kamen; Agol, Eric; Cowan, Nicolas; Desert, Jean-Michel; Fraine, Jonathan; Langton, Jonathan; Morley, Caroline; Showman, Adam P

    2014-01-01

    HAT-P-20b is a giant exoplanet that orbits a metal-rich star. The planet itself has a high total density, suggesting that it may also have a high metallicity in its atmosphere. We analyze two eclipses of the planet in each of the 3.6- and 4.5 micron bands of Warm Spitzer. These data exhibit intra-pixel detector sensitivity fluctuations that were resistant to traditional decorrelation methods. We have developed a simple, powerful, and radically different method to correct the intra-pixel effect for Warm Spitzer data, which we call pixel-level decorrelation (PLD). PLD corrects the intra-pixel effect very effectively, but without explicitly using - or even measuring - the fluctuations in the apparent position of the stellar image. We illustrate and validate PLD using synthetic and real data, and comparing the results to previous analyses. PLD can significantly reduce or eliminate red noise in Spitzer secondary eclipse photometry, even for eclipses that have proven to be intractable using other methods. Our succe...

  5. Demonstrating High-precision, Multi-band Transit Photometry with MuSCAT: A Case for HAT-P-14b

    CERN Document Server

    Fukui, Akihiko; Kawashima, Yui; Kusakabe, Nobuhiko; Onitsuka, Masahiro; Ryu, Tsuguru; Ikoma, Masahiro; Yanagisawa, Kenshi; Izumiura, Hideyuki

    2015-01-01

    The Multicolor Simultaneous Camera for studying Atmospheres of Transiting exoplanets (MuSCAT) is an optical three-band (g'_2-, r'_2-, and z_{s,2}-band) imager, recently developed for the 188cm telescope at Okayama Astrophysical Observatory with the aim of validating and characterizing transiting planets. In a pilot observation with MuSCAT, we observed a primary transit of HAT-P-14b, a high-surface gravity (g_p=38 ms^{-2}) hot Jupiter around a bright (V=10) F-type star. From a 2.9-hour observation, we achieve the 5-min binned photometric precisions of 0.028%, 0.022%, and 0.024% in the g'_2, r'_2, and z_{s,2} bands, respectively, providing the highest-quality photometric data for this planet. Combining these results with those of previous observations, we search for variations of transit timing and duration over five years, as well as variations of planet-star radius ratio (R_p/R_s) with wavelength, but find no considerable variation in any parameters. On the other hand, using the transit-subtracted light curve...

  6. Hubble Space Telescope hot Jupiter Transmission Spectral Survey: detection of water in HAT-P-1b from Wide Field Camera 3 near-infrared spatial scan observations

    CERN Document Server

    Wakeford, H R; Deming, D; Gibson, N P; Fortney, J J; Burrows, A S; Ballester, G; Nikolov, N; Aigrain, S; Henry, G; Knutson, H; Etangs, A Lecavelier des; Pont, F; Showman, A P; Vidal-Madjar, A; Zahnle, K

    2013-01-01

    We present Hubble Space Telescope near-infrared transmission spectroscopy of the transiting hot-Jupiter HAT-P-1b. We observed one transit with Wide Field Camera 3 using the G141 low-resolution grism to cover the wavelength range 1.087- 1.678 {\\mu}m. These time series observations were taken with the newly available spatial scan mode that increases the duty cycle by nearly a factor of two, thus improving the resulting photometric precision of the data. We measure a planet-to-star radius ratio of Rp/R*=0.11709+/-0.00038 in the white light curve with the centre of transit occurring at 2456114.345+/-0.000133 (JD). We achieve S/N levels per exposure of 1840 (0.061%) at a resolution of {\\Delta\\lambda}=19.2nm (R~70) in the 1.1173 - 1.6549{\\mu}m spectral region, providing the precision necessary to probe the transmission spectrum of the planet at close to the resolution limit of the instrument. We compute the transmission spectrum using both single target and differential photometry with similar results. The resultan...

  7. The optical transmission spectrum of the hot Jupiter HAT-P-32b: clouds explain the absence of broad spectral features?

    CERN Document Server

    Gibson, N P; Barstow, J K; Evans, T M; Fletcher, L N; Irwin, P G J

    2013-01-01

    We report Gemini-North GMOS observations of the inflated hot Jupiter HAT-P-32b during two primary transits. We simultaneously observed two comparison stars and used differential spectro-photometry to produce multi-wavelength light curves. 'White' light curves and 29 'spectral' light curves were extracted for each transit and analysed to refine the system parameters and produce transmission spectra from 520-930nm in ~14nm bins. The light curves contain time-varying white noise as well as time-correlated noise, and we used a Gaussian process model to fit this complex noise model. Common mode corrections derived from the white light curve fits were applied to the spectral light curves which significantly improved our precision, reaching typical uncertainties in the transit depth of ~2x10^-4, corresponding to about half a pressure scale height. The low resolution transmission spectra are consistent with a featureless model, and we can confidently rule out broad features larger than about one scale height. The abs...

  8. Uncertainties of the Gravity Recovery and Climate Experiment time-variable gravity-field solutions based on three-cornered hat method

    Science.gov (United States)

    Ferreira, Vagner G.; Montecino, Henry D. C.; Yakubu, Caleb I.; Heck, Bernhard

    2016-01-01

    Currently, various satellite processing centers produce extensive data, with different solutions of the same field being available. For instance, the Gravity Recovery and Climate Experiment (GRACE) has been monitoring terrestrial water storage (TWS) since April 2002, while the Center for Space Research (CSR), the Jet Propulsion Laboratory (JPL), the GeoForschungsZentrum (GFZ), and the Groupe de Recherche de Géodésie Spatiale (GRGS) provide individual monthly solutions in the form of Stokes coefficients. The inverted TWS maps (or the regionally averaged values) from these coefficients are being used in many applications; however, as no ground truth data exist, the uncertainties are unknown. Consequently, the purpose of this work is to assess the quality of each processing center by estimating their uncertainties using a generalized formulation of the three-cornered hat (TCH) method. Overall, the TCH results for the study period of August 2002 to June 2014 indicate that at a global scale, the CSR, GFZ, GRGS, and JPL presented uncertainties of 9.4, 13.7, 14.8, and 13.2 mm, respectively. At a basin scale, the overall good performance of the CSR was observed at 91 river basins. The TCH-based results were confirmed by a comparison with an ensemble solution from the four GRACE processing centers.

  9. The EVIL-MC Model for Ellipsoidal Variations of Planet-Hosting Stars and Applications to the HAT-P-7 System

    CERN Document Server

    Jackson, Brian K; Barnes, Jason W; Deming, L Drake; Showman, Adam P; Fortney, Jonathan J

    2012-01-01

    We present a new model for Ellipsoidal Variations Induced by a Low-Mass Companion, the EVIL-MC model. We employ several approximations appropriate for planetary systems to substantially increase the computational efficiency of our model relative to more general ellipsoidal variation models and improve upon the accuracy of simpler models. This new approach gives us a unique ability to rapidly and accurately determine planetary system parameters. We use the EVIL-MC model to analyze Kepler Quarter 0-2 (Q0-2) observations of the HAT-P-7 system, an F-type star orbited by a nearly Jupiter-mass companion. Our analysis corroborates previous estimates of the planet-star mass ratio q = (1.10 +/- 0.06) x 10^(-3), and we have revised the planet's dayside brightness temperature to 2680 +10/-20 K. We also find a large difference between the day- and nightside planetary flux, with little nightside emission. Preliminary dynamical+radiative modeling of the atmosphere indicates this result is qualitatively consistent with high...

  10. Uncertainties of the Gravity Recovery and Climate Experiment time-variable gravity-field solutions based on three-cornered hat method

    Science.gov (United States)

    Ferreira, Vagner G.; Montecino, Henry D. C.; Yakubu, Caleb I.; Heck, Bernhard

    2016-01-01

    Currently, various satellite processing centers produce extensive data, with different solutions of the same field being available. For instance, the Gravity Recovery and Climate Experiment (GRACE) has been monitoring terrestrial water storage (TWS) since April 2002, while the Center for Space Research (CSR), the Jet Propulsion Laboratory (JPL), the GeoForschungsZentrum (GFZ), and the Groupe de Recherche de Géodésie Spatiale (GRGS) provide individual monthly solutions in the form of Stokes coefficients. The inverted TWS maps (or the regionally averaged values) from these coefficients are being used in many applications; however, as no ground truth data exist, the uncertainties are unknown. Consequently, the purpose of this work is to assess the quality of each processing center by estimating their uncertainties using a generalized formulation of the three-cornered hat (TCH) method. Overall, the TCH results for the study period of August 2002 to June 2014 indicate that at a global scale, the CSR, GFZ, GRGS, and JPL presented uncertainties of 9.4, 13.7, 14.8, and 13.2 mm, respectively. At a basin scale, the overall good performance of the CSR was observed at 91 river basins. The TCH-based results were confirmed by a comparison with an ensemble solution from the four GRACE processing centers.

  11. Time-resolved luminescence biosensor for continuous activity detection of protein acetylation-related enzymes based on DNA-sensitized terbium(III) probes.

    Science.gov (United States)

    Han, Yitao; Li, Hao; Hu, Yufang; Li, Pei; Wang, Huixia; Nie, Zhou; Yao, Shouzhuo

    2015-09-15

    Protein acetylation of histone is an essential post-translational modification (PTM) mechanism in epigenetic gene regulation, and its status is reversibly controlled by histone acetyltransferases (HATs) and histone deacetylases (HDACs). Herein, we have developed a sensitive and label-free time-resolved luminescence (TRL) biosensor for continuous detection of enzymatic activity of HATs and HDACs, respectively, based on acetylation-mediated peptide/DNA interaction and Tb(3+)/DNA luminescent probes. Using guanine (G)-rich DNA-sensitized Tb(3+) luminescence as the output signal, the polycationic substrate peptides interact with DNA with high affinity and subsequently replace Tb(3+), eliminating the luminescent signal. HAT-catalyzed acetylation remarkably reduces the positive charge of the peptides and diminishes the peptide/DNA interaction, resulting in the signal on detection via recovery of DNA-sensitized Tb(3+) luminescence. With this TRL sensor, HAT (p300) can be sensitively detected with a wide linear range from 0.2 to 100 nM and a low detection limit of 0.05 nM. The proposed sensor was further used to continuously monitor the HAT activity in real time. Additionally, the TRL biosensor was successfully applied to evaluating HAT inhibition by two specific inhibitors, anacardic acid and C464, and satisfactory Z'-factors above 0.73 were obtained. Moreover, this sensor is feasible to continuously monitor the HDAC (Sirt1)-catalyzed deacetylation with a linear range from 0.5 to 500 nM and a detection limit of 0.5 nM. The proposed sensor is a convenient, sensitive, and mix-and-read assay, presenting a promising platform for protein acetylation-targeted epigenetic research and drug discovery. PMID:26307596

  12. Time-resolved luminescence biosensor for continuous activity detection of protein acetylation-related enzymes based on DNA-sensitized terbium(III) probes.

    Science.gov (United States)

    Han, Yitao; Li, Hao; Hu, Yufang; Li, Pei; Wang, Huixia; Nie, Zhou; Yao, Shouzhuo

    2015-09-15

    Protein acetylation of histone is an essential post-translational modification (PTM) mechanism in epigenetic gene regulation, and its status is reversibly controlled by histone acetyltransferases (HATs) and histone deacetylases (HDACs). Herein, we have developed a sensitive and label-free time-resolved luminescence (TRL) biosensor for continuous detection of enzymatic activity of HATs and HDACs, respectively, based on acetylation-mediated peptide/DNA interaction and Tb(3+)/DNA luminescent probes. Using guanine (G)-rich DNA-sensitized Tb(3+) luminescence as the output signal, the polycationic substrate peptides interact with DNA with high affinity and subsequently replace Tb(3+), eliminating the luminescent signal. HAT-catalyzed acetylation remarkably reduces the positive charge of the peptides and diminishes the peptide/DNA interaction, resulting in the signal on detection via recovery of DNA-sensitized Tb(3+) luminescence. With this TRL sensor, HAT (p300) can be sensitively detected with a wide linear range from 0.2 to 100 nM and a low detection limit of 0.05 nM. The proposed sensor was further used to continuously monitor the HAT activity in real time. Additionally, the TRL biosensor was successfully applied to evaluating HAT inhibition by two specific inhibitors, anacardic acid and C464, and satisfactory Z'-factors above 0.73 were obtained. Moreover, this sensor is feasible to continuously monitor the HDAC (Sirt1)-catalyzed deacetylation with a linear range from 0.5 to 500 nM and a detection limit of 0.5 nM. The proposed sensor is a convenient, sensitive, and mix-and-read assay, presenting a promising platform for protein acetylation-targeted epigenetic research and drug discovery.

  13. Application Study on Six Thinking Hats Thinking Mode in Clinical Teaching of Traditional Chinese Medicine%“六顶思考帽”思维方式在中医临床带教中应用探讨

    Institute of Scientific and Technical Information of China (English)

    丁永利

    2016-01-01

    “六顶思考帽”的提出者是马耳他医学博士爱德华•德•波诺,其核心思想是建立一种积极热情、勇敢无畏且富有创造精神的科学思维模式。该模式采用白、红、绿、黑、黄、蓝六种颜色不同的帽子代表六种不同的思维模式。该文主要介绍了“六顶思考帽”的基本定义,阐述了“六顶思考帽”在中医临床带教中的应用,强调了多维思考的重要性,通过该文研究,最终实现中医临床研究的思考模式。%The presenter of six thinking hats is Malta medical doctor Edward de Bono, the core concept is to build a scien-tific thinking mode that is positive and enthusiastic, brave and full of creative spirit. The model adopts hats of six colors such as white, red, green, blank, yellow and blue to represent six thinking models. The paper mainly introduces the basic definition of six thinking hats, elaborates the application of six thinking hats in clinical teaching of traditional Chinese medicine and emphasizes the importance of multidimensional reflections, and the thinking model of the clinical research of traditional Chinese medicine will be finally realized by the research of this paper.

  14. 3.6 and 4.5 $\\mu$m ${\\it Spitzer}$ Phase Curves of the Highly-Irradiated Hot Jupiters WASP-19b and HAT-P-7b

    CERN Document Server

    Wong, Ian; Kataria, Tiffany; Lewis, Nikole K; Burrows, Adam; Fortney, Jonathan J; Schwartz, Joel; Shporer, Avi; Agol, Eric; Cowan, Nicholas B; Deming, Drake; Desert, Jean-Michel; Fulton, Benjamin J; Howard, Andrew W; Langton, Jonathan; Laughlin, Gregory; Showman, Adam P; Todorov, Kamen

    2016-01-01

    We analyze full-orbit phase curve observations of the transiting hot Jupiters WASP-19b and HAT-P-7b at 3.6 and 4.5 $\\mu$m obtained using the Spitzer Space Telescope. For WASP-19b, we measure secondary eclipse depths of $0.485\\%\\pm 0.024\\%$ and $0.584\\%\\pm 0.029\\%$ at 3.6 and 4.5 $\\mu$m, which are consistent with a single blackbody with effective temperature $2372 \\pm 60$ K. The measured 3.6 and 4.5 $\\mu$m secondary eclipse depths for HAT-P-7b are $0.156\\%\\pm 0.009\\%$ and $0.190\\%\\pm 0.006\\%$, which are well-described by a single blackbody with effective temperature $2667\\pm 57$ K. Comparing the phase curves to the predictions of one-dimensional and three-dimensional atmospheric models, we find that WASP-19b's dayside emission is consistent with a model atmosphere with no dayside thermal inversion and moderately efficient day-night circulation. We also detect an eastward-shifted hotspot, suggesting the presence of a superrotating equatorial jet. In contrast, HAT-P-7b's dayside emission suggests a dayside therm...

  15. Phenolic Constituents of Medicinal Plants with Activity against Trypanosoma brucei

    Directory of Open Access Journals (Sweden)

    Ya Nan Sun

    2016-04-01

    Full Text Available Neglected tropical diseases (NTDs affect over one billion people all over the world. These diseases are classified as neglected because they impact populations in areas with poor financial conditions and hence do not attract sufficient research investment. Human African Trypanosomiasis (HAT or sleeping sickness, caused by the parasite Trypanosoma brucei, is one of the NTDs. The current therapeutic interventions for T. brucei infections often have toxic side effects or require hospitalization so that they are not available in the rural environments where HAT occurs. Furthermore, parasite resistance is increasing, so that there is an urgent need to identify novel lead compounds against this infection. Recognizing the wide structural diversity of natural products, we desired to explore and identify novel antitrypanosomal chemotypes from a collection of natural products obtained from plants. In this study, 440 pure compounds from various medicinal plants were tested against T. brucei by in a screening using whole cell in vitro assays. As the result, twenty-two phenolic compounds exhibited potent activity against cultures of T. brucei. Among them, eight compounds—4, 7, 11, 14, 15, 18, 20, and 21—showed inhibitory activity against T. brucei, with IC50 values below 5 µM, ranging from 0.52 to 4.70 μM. Based on these results, we attempt to establish some general trends with respect to structure-activity relationships, which indicate that further investigation and optimization of these derivatives might enable the preparation of potentially useful compounds for treating HAT.

  16. 六帽思维是深度沟通的桥梁%Six-hat Thinking is the Bridge of Depth Communication

    Institute of Scientific and Technical Information of China (English)

    白洪春; 白洪魁

    2012-01-01

    传统的逻辑思维是一种纵向的思维模式,有着使思维复杂化、片面化和对抗性的三大弊端。英国学者爱德华.德.波诺博士从平行思维的角度,开发的六顶思考帽思维模式,为人们提供了"平行思维"的工具,有效地避免了传统思维的弊端。运用六帽思维沟通方法具有能够避免沟通的对抗性、方法简捷使沟通具有高效性、分层次思维使沟通思路清晰、分解问题使沟通化繁为简、和谐情境使沟通增强团队创新能力、系统的观点使沟通的结论更全面和准确等优点,是值得推广的沟通方法。%Traditional logical thinking is a longitudinal mode of thinking,has three drawbacks of being complicated,one-sided and antagonistic.Ph.D Edward De Bono,a British scholar,developed six –hat thinking mode from the perspective of parallel thinking,providing people with a "parallel thinking tool to avoid the drawbacks of traditional thinking.This thinking method is able to avoid confrontation of communication,communicate ideas clearly and efficiently,simplify communication,create harmony situation,and enhance team innovation capability,offer more comprehensive and accurate conclusion.

  17. Activities.

    Science.gov (United States)

    Moody, Mally

    1992-01-01

    A series of four activities are presented to enhance students' abilities to appreciate and use trigonometry as a tool in problem solving. Activities cover problems applying the law of sines, the law of cosines, and matching equivalent trigonometric expressions. A teacher's guide, worksheets, and answers are provided. (MDH)

  18. MRG15 activates the cdc2 promoter via histone acetylation in human cells

    Energy Technology Data Exchange (ETDEWEB)

    Pena, AndreAna N., E-mail: andreana.pena@gmail.com [Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX (United States); Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX (United States); Tominaga, Kaoru; Pereira-Smith, Olivia M. [Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX (United States); Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX (United States)

    2011-07-01

    Chromatin remodeling is required for transcriptional activation and repression. MRG15 (MORF4L1), a chromatin modulator, is a highly conserved protein and is present in complexes containing histone acetyltransferases (HATs) as well as histone deacetylases (HDACs). Loss of expression of MRG15 in mice and Drosophila results in embryonic lethality and fibroblast and neural stem/progenitor cells cultured from Mrg15 null mouse embryos exhibit marked proliferative defects when compared with wild type cells. To determine the role of MRG15 in cell cycle progression we performed chromatin immunoprecipitation with an antibody to MRG15 on normal human fibroblasts as they entered the cell cycle from a quiescent state, and analyzed various cell cycle gene promoters. The results demonstrated a 3-fold increase in MRG15 occupancy at the cdc2 promoter during S phase of the cell cycle and a concomitant increase in acetylated histone H4. H4 lysine 12 was acetylated at 24 h post-serum stimulation while there was no change in acetylation of lysine 16. HDAC1 and 2 were decreased at this promoter during cell cycle progression. Over-expression of MRG15 in HeLa cells activated a cdc2 promoter-reporter construct in a dose-dependent manner, whereas knockdown of MRG15 resulted in decreased promoter activity. In order to implicate HAT activity, we treated cells with the HAT inhibitor anacardic acid and determined that HAT inhibition results in loss of expression of cdc2 mRNA. Further, chromatin immunoprecipitation with Tip60 localizes the protein to the same 110 bp stretch of the cdc2 promoter pulled down by MRG15. Additionally, we determined that cotransfection of MRG15 with the known associated HAT Tip60 had a cooperative effect in activating the cdc2 promoter. These results suggest that MRG15 is acting in a HAT complex involving Tip60 to modify chromatin via acetylation of histone H4 at the cdc2 promoter to activate transcription.

  19. Genetically modified pigs produced with a nonviral episomal vector

    OpenAIRE

    Manzini, Stefano; Vargiolu, Alessia; Stehle, Isa M; Bacci, Maria Laura; Cerrito, Maria Grazia; Giovannoni, Roberto; Zannoni, Augusta; Bianco, Maria Rosaria; Forni, Monica; Donini, Pierluigi; Papa, Michele; Lipps, Hans J; Lavitrano, Marialuisa

    2006-01-01

    Genetic modification of cells and animals is an invaluable tool for biotechnology and biomedicine. Currently, integrating vectors are used for this purpose. These vectors, however, may lead to insertional mutagenesis and variable transgene expression and can undergo silencing. Scaffold/matrix attachment region-based vectors are nonviral expression systems that replicate autonomously in mammalian cells, thereby making possible safe and reliable genetic modification of higher eukaryotic cells a...

  20. Wearing more than one hat?

    DEFF Research Database (Denmark)

    Høgedahl, Laust Kristian; Ibsen, Flemming

    bargaining round and the teacher lockout in 2013. The article shows how the use of collective industrial conflicts in the public sector has a number of built-in systemic flaws, as the public employers are at one and the same time the budgetary authority and legislators. This is not a new finding, however...

  1. THE TRADE TIES HAT BIND

    Institute of Scientific and Technical Information of China (English)

    MATT; YOUNG

    2006-01-01

    Chinese President Hu Jintao made his first state visit to the United States April 19-21. The president kicked off his tour in Seattle, where he had intense contact with the American business community as represented by Boeing and Microsoft. Hu then landed in Washington D.C. for a summit meeting with President George W. Bush, followed by a visit to Yale University. During the meeting with Bush, Hu conveyed the idea that China and the United States are "not only stakeholders, but also constructive partners...

  2. All Hat and No Cattle

    Science.gov (United States)

    Holloway-Libell, Jessica; Amrein-Beardsley, Audrey; Collins, Clarin

    2012-01-01

    Recently, two of the authors (Amrein-Beardsley & Collins, 2012) studied the impact of Education Value-Added Assessment System (EVAAS), a value-added model used to judge Houston teachers' performance. They examined the cases of four teachers who were terminated in summer 2011, at least in part because of their subpar EVAAS scores. Talking to these…

  3. Gene panels to help identify subgroups at high and low risk of CHD among those randomized to antihypertensive treatment: The GenHAT Study

    Science.gov (United States)

    Lynch, Amy I.; Eckfeldt, John H.; Davis, Barry R.; Ford, Charles E.; Boerwinkle, Eric; Leiendecker-Foster, Catherine; Arnett, Donna K.

    2012-01-01

    Objective To identify panels of genetic variants that predict treatment-related coronary heart disease (CHD) outcomes in hypertensive patients on one of four different classes of initial antihypertensive treatment. The goal was to identify subgroups of people based on their genetic profile who benefit most from a particular treatment. Methods Candidate genetic variants (n=78) were genotyped in 39,114 participants from GenHAT, ancillary to ALLHAT. ALLHAT randomized hypertensive participants (>=55 years) to one of four treatments (amlodipine, chlorthalidone, doxazosin, lisinopril). The primary outcome was fatal CHD or non-fatal MI (mean follow-up=4.9 years). A pharmacogenetic panel was derived within each of the four treatment groups. ROC curves estimated the discrimination rate between those with and without a CHD event, based on the addition of the genetic panel risk score. Results For each treatment group, we identified a panel of genetic variants that collectively improved prediction of CHD to a small but statistically significant extent. Chlorthalidone (A): NOS3, rs3918226; SELE, rs5361; ICAM1, rs1799969; AGT, rs5051; GNAS, rs7121; ROC comparison p=.004; Amlodipine (B): MMP1, rs1799750; F5, rs6025; NPPA, rs5065; PDE4D, rs6450512; MMP9, rs2274756; ROC comparison p=.006; Lisinopril (C): AGT, rs5051; PON1, rs705379; MMP12, rs652438; F12, rs1801020; GP1BA, rs6065; PDE4D, rs27653; ROC comparison p=.01; Doxazosin (D): F2, rs1799963; PAI1, rs1799768; MMP7, rs11568818; AGT, rs5051; ACE, rs4343; MMP2, rs243865; ROC comparison p=.007. Each panel was tested for a pharmacogenetic effect; panels A, B and D showed such evidence (p=.009, .006, and .001 respectively), panel C did not (p=.09). Conclusion Because each panel was associated with CHD in a specific treatment group but not the others, this research provides evidence that it may be possible to use gene panel scores as a tool to better assess antihypertensive treatment choices to reduce CHD risk in hypertensive

  4. Tarih Algısı Bağlamında Postmodern Bir Anlatı: İstanbul Hatırası A Postmodern Narration in the Context of History Perception: İstanbul Hatırası

    Directory of Open Access Journals (Sweden)

    Mustafa AYDEMİR

    2012-09-01

    Full Text Available Detective novel, formed around an intelligently planned murder and a detective who tries to solve it and find the murderer, shows a significant improvement with the influence of Postmodernism, which rose in the second half of 20th Century. That improvement first shows its face in translation, then writing in Turkish Literature. The history of detective novel, which began to take its place inliterary history due to the emergence of crime and along withurbanization, is as old as the concept of crime history. Having aparticular history, it can be claimed that it prepared the ground for theemergence of novel. However, two major war, which happened in the20th century, has led to a rapid development of the detective novel, thebest way to tell the story of the crimes.Ahmet Ümit’s novel İstanbul Hatırası is important as it shows thechange of detective novel in Turkish novel. A real – up to date and anunreal – historical, two different engaging fictions are being narrated inthat detective novel. Beginning with the murder, a journey to thehistorical sites of Istanbul is made. In addition, the importances ofthese sites, which are close to be destroyed, are pointed out.In this study, after mentioning how detective novel emerged inWest and Turkish Literature and its historic development, Ahmet Ümit’sİstanbul Hatırası has been analyzed and postmodern features in thisnovel has been emphasized. With this method, postmoderncharacteristics of the novel has been taken care in terms of plot, time,place, characters and the classical elements of the novel has beenevaluated with a postmodernist approach. Zekice plânlanmış bir cinayet ve onu çözmeye, katili bulmaya çalışan bir dedektif etrafında şekillenen polisiye roman, 20. yüzyılın ikinci yarısında ortaya çıkan postmodernizmin de etkisiyle önemli bir gelişme gösterir. Bu gelişme, Türk edebiyatında önce çeviri, sonra da telif yoluyla kendini gösterir. Suçun ortaya

  5. hatü’l-İnsân (Pend-Nâme-i Enûşîrvân’ın Türkçe Bir Tercümesi A Turkish Translation of Râhatü’l-İnsân (Pend-Nâme-i Enûşîrvân

    Directory of Open Access Journals (Sweden)

    Müjgân ÇAKIR

    2012-09-01

    Full Text Available Islamic literatures include many texts on the justice and counsels of Sassanian ruler Nûşîrevân. One of these is a work of Persian Literature which recounts the counsels written on his crown and figures with the titles of “Râhatü’l-insân” or “Pend-nâme-i Enûşîrvân” in some sources. Rıza Kulı Han Hidayet states that the text belongs to Bedâyi‛-i Belhî; however the identity of the author is disputed. It is also argued that the “Şerîf-i Şair,” whose name appears in the introduction to the text edited by Charles Schefer in his work entitled Chrestomathie Persane, is Ebû Şerîf Muhalledi-yi Gurgânî. Râhatü’l-insân has manuscripts in Turkish libraries. This article treats this work and its Turkish prose translation located at Süleymaniye Library, Fatih Section No. 5385 under the title “Pend-i Nûşîrevân-ı Âdil.” In this translation, the counsels written on the seventeen slices (küngüre of Nûşîrevân’s crown are given and it is told that this ruler had his crown put up somewhere appropriate every year for the soldiers to read his counsels. The purposes of Nûşîrevân’s counsels are proving a moral education to the public, directing his relations with his people as well as organizing the relations between them. Some of the counsels written on Nûşîrevân’s crown are as follows: “Respect the old and the weak, observe the rights of your parents, consult scholars before you do your business, have a command of your speech, do not betray trust, think before you speak.” The article will also treat some of the differences between the Persian manuscripts of the work and its Turkish translation. The transcription of the Turkish translation will be given. İslâmî edebiyatlarda Sasani hükümdarı Nûşîrevân’ın adaleti ve nasihatlarıyla ilgili birçok metin yazılmıştır. Bu metinlerden biri Fars Edebiyatı’nda onun tacının üzerinde yazılı olan nasihatları anlatan ve baz

  6. Growth factor-activated stem cell circuits and stromal signals cooperatively accelerate non-integrated iPSC reprogramming of human myeloid progenitors.

    Directory of Open Access Journals (Sweden)

    Tea Soon Park

    Full Text Available Nonviral conversion of skin or blood cells into clinically useful human induced pluripotent stem cells (hiPSC occurs in only rare fractions (~0.001%-0.5% of donor cells transfected with non-integrating reprogramming factors. Pluripotency induction of developmentally immature stem-progenitors is generally more efficient than differentiated somatic cell targets. However, the nature of augmented progenitor reprogramming remains obscure, and its potential has not been fully explored for improving the extremely slow pace of non-integrated reprogramming. Here, we report highly optimized four-factor reprogramming of lineage-committed cord blood (CB myeloid progenitors with bulk efficiencies of ~50% in purified episome-expressing cells. Lineage-committed CD33(+CD45(+CD34(- myeloid cells and not primitive hematopoietic stem-progenitors were the main targets of a rapid and nearly complete non-integrated reprogramming. The efficient conversion of mature myeloid populations into NANOG(+TRA-1-81(+ hiPSC was mediated by synergies between hematopoietic growth factor (GF, stromal activation signals, and episomal Yamanaka factor expression. Using a modular bioinformatics approach, we demonstrated that efficient myeloid reprogramming correlated not to increased proliferation or endogenous Core factor expressions, but to poised expression of GF-activated transcriptional circuits that commonly regulate plasticity in both hematopoietic progenitors and embryonic stem cells (ESC. Factor-driven conversion of myeloid progenitors to a high-fidelity pluripotent state was further accelerated by soluble and contact-dependent stromal signals that included an implied and unexpected role for Toll receptor-NFκB signaling. These data provide a paradigm for understanding the augmented reprogramming capacity of somatic progenitors, and reveal that efficient induced pluripotency in other cell types may also require extrinsic activation of a molecular framework that commonly

  7. Yaşar Şadi Efendi’nin “Hutut-ı Meşahir” İsimli Hatıra Defteri ve Muhtevası

    OpenAIRE

    Berk, Süleyman

    2015-01-01

    “Hutût-ı Meşâhir” mecmuaları bir nevi hatıra defterlerini andıran çalışmalardır. Hatıra defterlerinden farkı, çok çeşitli kimselerin, kendilerine sunulan deftere, el yazıları ile o an akla gelenleri, şiirleri, özlü sözleri yazmaları veya maharetlerini aktarmalarıdır. Şimdiye kadar ancak baskılarını görebildiğimiz bazı hutût-ı meşâhir mecmuaları içerisinde en kapsamlı olanı Yaşar Şâdi’nin hazırladığı sözünü ettiğimiz mecmua gibi görülüyor. Yaşar Şâdi, 1336/1920 ile 1338/1923 yıl...

  8. Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274

    Institute of Scientific and Technical Information of China (English)

    Bingfa Sun; Shunling Guo; Qingyu Tang; Chen Li; Rong Zeng; Zhiqi Xiong; Chen Zhong; Jianping Ding

    2011-01-01

    Dear Editor, Males-absent-on-the-first (MOF, also called MYST1 or KAT8) is a histone acetyltransferase (HAT) belonging to the MOZ, Ybf2/Sas3, Sas2 and Tip60 (MYST) family.MOF has been shown to possess a specific HAT activity towards Lysl6 of histone H4 (H4K16) [1].Homozygous knockout of MOF in mice results in loss of H4K16 acetylation and embryonic lethality, indicating that MOF and H4K16 acetylation are essential for embryogenesis and genome stability in mammals [2].Downregulation of human MOF (hMOF) leads to dramatic nuclear morphological deformation and inhibition of cell cycle progression [3], and has recently been correlated with primary breast carcinoma and medulloblastoma [4].

  9. The Influence of Peripheral Substituent Modification on P(V), Mn(III), and Mn(V)(O) Corrolazines: X-ray Crystallography, Electrochemical and Spectroscopic Properties, and HAT and OAT Reactivities.

    Science.gov (United States)

    Joslin, Evan E; Zaragoza, Jan Paulo T; Baglia, Regina A; Siegler, Maxime A; Goldberg, David P

    2016-09-01

    The influence of remote peripheral substitution on the physicochemical properties and reactivity of phosphorus and manganese corrolazine (Cz) complexes was examined. The substitution of p-MeO for p-t-Bu groups on the eight phenyl substituents of the β-carbon atoms of the Cz ring led to changes in UV-vis transitions and redox potentials for each of the complexes. The oxygen atom transfer (OAT) and hydrogen atom transfer (HAT) reactivity of the Mn(V)(O) complexes was also influenced by p-MeO substitution. The OAT reactivity of Mn(V)(O)(MeOP8Cz) (MeOP8Cz = octakis(p-methoxyphenyl)corrolazinato(3-)) with triarylphosphine (PAr3) substrates led to second-order rate constants from 10.2(5) to 3.1(2) × 10(4) M(-1) s(-1). These rates of OAT are slower than those seen for Mn(V)(O)(TBP8Cz) (TBP8Cz = octakis(p-tert-butylphenyl)corrolazinato(3-)). A Hammett study involving para-substituted PAr3 substrates reveals a Hammett ρ-value for Mn(V)(O)(MeOP8Cz) that is more negative than that observed for Mn(V)(O)(TBP8Cz), consistent with a less electrophilic Mn center. The HAT reactivity of Mn(V)(O)(MeOP8Cz) with C-H substrates was examined and revealed second-order rate constants from 6.8(5) × 10(-5) to 1.70(2) × 10(-1) M(-1) s(-1). The rate constants varied with the C-H bond strength of the substrate. Slightly faster HAT rates with C-H substrates were observed with Mn(V)(O)(MeOP8Cz) compared to Mn(V)(O)(TBP8Cz), indicating that the basicity of the putative [Mn(IV)(O)](-) intermediate likely compensates for the more negative redox potential in the driving force for HAT. In addition, the complete, large-scale synthesis of the para-phenyl-substituted porphyrazines RP8PzH2 (R = p-tert-butylphenyl (TB), p-methoxyphenyl (MeO), and p-isopropylphenyl) and corrolazines RP8CzH3 (TBP8CzH3 and MeOP8CzH3) is presented. The crystal structures of the monoprotonated, metal-free corrolazine [(TBP8CzH3)(H)](+)[BArF](-), P(V)(OMe)2(MeOP8Cz), and Mn(III)(MeOP8Cz)(MeOH) are presented. This work

  10. The Influence of Peripheral Substituent Modification on P(V), Mn(III), and Mn(V)(O) Corrolazines: X-ray Crystallography, Electrochemical and Spectroscopic Properties, and HAT and OAT Reactivities.

    Science.gov (United States)

    Joslin, Evan E; Zaragoza, Jan Paulo T; Baglia, Regina A; Siegler, Maxime A; Goldberg, David P

    2016-09-01

    The influence of remote peripheral substitution on the physicochemical properties and reactivity of phosphorus and manganese corrolazine (Cz) complexes was examined. The substitution of p-MeO for p-t-Bu groups on the eight phenyl substituents of the β-carbon atoms of the Cz ring led to changes in UV-vis transitions and redox potentials for each of the complexes. The oxygen atom transfer (OAT) and hydrogen atom transfer (HAT) reactivity of the Mn(V)(O) complexes was also influenced by p-MeO substitution. The OAT reactivity of Mn(V)(O)(MeOP8Cz) (MeOP8Cz = octakis(p-methoxyphenyl)corrolazinato(3-)) with triarylphosphine (PAr3) substrates led to second-order rate constants from 10.2(5) to 3.1(2) × 10(4) M(-1) s(-1). These rates of OAT are slower than those seen for Mn(V)(O)(TBP8Cz) (TBP8Cz = octakis(p-tert-butylphenyl)corrolazinato(3-)). A Hammett study involving para-substituted PAr3 substrates reveals a Hammett ρ-value for Mn(V)(O)(MeOP8Cz) that is more negative than that observed for Mn(V)(O)(TBP8Cz), consistent with a less electrophilic Mn center. The HAT reactivity of Mn(V)(O)(MeOP8Cz) with C-H substrates was examined and revealed second-order rate constants from 6.8(5) × 10(-5) to 1.70(2) × 10(-1) M(-1) s(-1). The rate constants varied with the C-H bond strength of the substrate. Slightly faster HAT rates with C-H substrates were observed with Mn(V)(O)(MeOP8Cz) compared to Mn(V)(O)(TBP8Cz), indicating that the basicity of the putative [Mn(IV)(O)](-) intermediate likely compensates for the more negative redox potential in the driving force for HAT. In addition, the complete, large-scale synthesis of the para-phenyl-substituted porphyrazines RP8PzH2 (R = p-tert-butylphenyl (TB), p-methoxyphenyl (MeO), and p-isopropylphenyl) and corrolazines RP8CzH3 (TBP8CzH3 and MeOP8CzH3) is presented. The crystal structures of the monoprotonated, metal-free corrolazine [(TBP8CzH3)(H)](+)[BArF](-), P(V)(OMe)2(MeOP8Cz), and Mn(III)(MeOP8Cz)(MeOH) are presented. This work

  11. Hatékony leadership magatartások szlovák szervezeti környezetben (Effective leadership behaviors in Slovak organizational environment – Introduction to the Slovak implict leadership theories –Results of the GLOBE research)

    OpenAIRE

    Bauer, Dávid

    2014-01-01

    Az itt bemutatott kutatás célja az volt, hogy azonosítsa és feltárja a szlovák vállalati környezetben követett és kívánatosnak tartott leadership dimenziókat és bemutassa azokat az implicit leadership elmélet alapján meghatározott magatartásokat, amelyek a sikeres leadershipet támogató magatartásokként jelennek meg (az implicit leadership elmélet szerint az egyének magatartásokhoz kapcsolódó hiedelmeik, meggyőződéseik és értékítéleteik alapján határozzák meg, kit tekintenek vezető...

  12. 论《麦田里的守望者》中霍尔顿帽子的象征意义%Symbolic meaning of Holden Caulfield' s hat in The Catcher in the Rye

    Institute of Scientific and Technical Information of China (English)

    孙珂

    2012-01-01

    Symbolism is extensively employed in hterary writings to convey some particular impheation that is hidden in the context but fully embodies the theme of the work. Salinger employs the device of symbohsm in his The Catcher in the Rye to reflect the emptiness and painfulness of teenager' s sate of mind,which is in radical contrast with the economic prosperity after the Second World War in the U. S. A. In this paper,the color,the peak,the name of the hat,and the time Holden wears it are carefully examined to cast light on the symbulic meaning of a red hunting hat,a small item that accompanies Holden Caulfield in the short period of his initiation.%在文学创作中,象征作为一种隐晦的表现手法被广泛用来深化作品的主题,塞林格在其代表作《麦田里的守望者》一书中运用这一手法,含蓄地反映了美国六十年代经济繁荣背后人们内心的空虚,特别是青少年成长过程中的迷惘心态。通过对小说中伴随主人公霍尔顿成长的猎帽的名字、颜色、鸭舌和霍尔顿佩戴猎帽的时间进行详细分析,阐述了《麦田里的守望者》中猎帽所蕴含的象征意义。

  13. Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation.

    Directory of Open Access Journals (Sweden)

    Cary A Moody

    2009-10-01

    Full Text Available Human papillomaviruses (HPV are the causative agents of cervical cancers. The infectious HPV life cycle is closely linked to the differentiation state of the host epithelia, with viral genome amplification, late gene expression and virion production restricted to suprabasal cells. The E6 and E7 proteins provide an environment conducive to DNA synthesis upon differentiation, but little is known concerning the mechanisms that regulate productive viral genome amplification. Using keratinocytes that stably maintain HPV-31 episomes, and chemical inhibitors, we demonstrate that viral proteins activate the ATM DNA damage response in differentiating cells, as indicated by phosphorylation of CHK2, BRCA1 and NBS1. This activation is necessary for viral genome amplification, as well as for formation of viral replication foci. In contrast, inhibition of ATM kinase activity in undifferentiated keratinocytes had no effect on the stable maintenance of viral genomes. Previous studies have shown that HPVs induce low levels of caspase 3/7 activation upon differentiation and that this is important for cleavage of the E1 replication protein and genome amplification. Our studies demonstrate that caspase cleavage is induced upon differentiation of HPV positive cells through the action of the DNA damage protein kinase CHK2, which may be activated as a result of E7 binding to the ATM kinase. These findings identify a major regulatory mechanism responsible for productive HPV replication in differentiating cells. Our results have potential implications for the development of anti-viral therapies to treat HPV infections.

  14. The cellular bromodomain protein Brd4 has multiple functions in E2-mediated papillomavirus transcription activation.

    Science.gov (United States)

    Helfer, Christine M; Yan, Junpeng; You, Jianxin

    2014-08-01

    The cellular bromodomain protein Brd4 functions in multiple processes of the papillomavirus life cycle, including viral replication, genome maintenance, and gene transcription through its interaction with the viral protein, E2. However, the mechanisms by which E2 and Brd4 activate viral transcription are still not completely understood. In this study, we show that recruitment of positive transcription elongation factor b (P-TEFb), a functional interaction partner of Brd4 in transcription activation, is important for E2's transcription activation activity. Furthermore, chromatin immunoprecipitation (ChIP) analyses demonstrate that P-TEFb is recruited to the actual papillomavirus episomes. We also show that E2's interaction with cellular chromatin through Brd4 correlates with its papillomavirus transcription activation function since JQ1(+), a bromodomain inhibitor that efficiently dissociates E2-Brd4 complexes from chromatin, potently reduces papillomavirus transcription. Our study identifies a specific function of Brd4 in papillomavirus gene transcription and highlights the potential use of bromodomain inhibitors as a method to disrupt the human papillomavirus (HPV) life cycle. PMID:25140737

  15. The Cellular Bromodomain Protein Brd4 has Multiple Functions in E2-Mediated Papillomavirus Transcription Activation

    Directory of Open Access Journals (Sweden)

    Christine M. Helfer

    2014-08-01

    Full Text Available The cellular bromodomain protein Brd4 functions in multiple processes of the papillomavirus life cycle, including viral replication, genome maintenance, and gene transcription through its interaction with the viral protein, E2. However, the mechanisms by which E2 and Brd4 activate viral transcription are still not completely understood. In this study, we show that recruitment of positive transcription elongation factor b (P-TEFb, a functional interaction partner of Brd4 in transcription activation, is important for E2’s transcription activation activity. Furthermore, chromatin immunoprecipitation (ChIP analyses demonstrate that P-TEFb is recruited to the actual papillomavirus episomes. We also show that E2’s interaction with cellular chromatin through Brd4 correlates with its papillomavirus transcription activation function since JQ1(+, a bromodomain inhibitor that efficiently dissociates E2-Brd4 complexes from chromatin, potently reduces papillomavirus transcription. Our study identifies a specific function of Brd4 in papillomavirus gene transcription and highlights the potential use of bromodomain inhibitors as a method to disrupt the human papillomavirus (HPV life cycle.

  16. SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis.

    Directory of Open Access Journals (Sweden)

    Robert T Jacobs

    2011-06-01

    Full Text Available BACKGROUND: Human African trypanosomiasis (HAT is an important public health problem in sub-Saharan Africa, affecting hundreds of thousands of individuals. An urgent need exists for the discovery and development of new, safe, and effective drugs to treat HAT, as existing therapies suffer from poor safety profiles, difficult treatment regimens, limited effectiveness, and a high cost of goods. We have discovered and optimized a novel class of small-molecule boron-containing compounds, benzoxaboroles, to identify SCYX-7158 as an effective, safe and orally active treatment for HAT. METHODOLOGY/PRINCIPAL FINDINGS: A drug discovery project employing integrated biological screening, medicinal chemistry and pharmacokinetic characterization identified SCYX-7158 as an optimized analog, as it is active in vitro against relevant strains of Trypanosoma brucei, including T. b. rhodesiense and T. b. gambiense, is efficacious in both stage 1 and stage 2 murine HAT models and has physicochemical and in vitro absorption, distribution, metabolism, elimination and toxicology (ADMET properties consistent with the compound being orally available, metabolically stable and CNS permeable. In a murine stage 2 study, SCYX-7158 is effective orally at doses as low as 12.5 mg/kg (QD×7 days. In vivo pharmacokinetic characterization of SCYX-7158 demonstrates that the compound is highly bioavailable in rodents and non-human primates, has low intravenous plasma clearance and has a 24-h elimination half-life and a volume of distribution that indicate good tissue distribution. Most importantly, in rodents brain exposure of SCYX-7158 is high, with C(max >10 µg/mL and AUC(0-24 hr >100 µg*h/mL following a 25 mg/kg oral dose. Furthermore, SCYX-7158 readily distributes into cerebrospinal fluid to achieve therapeutically relevant concentrations in this compartment. CONCLUSIONS/SIGNIFICANCE: The biological and pharmacokinetic properties of SCYX-7158 suggest that this compound will be

  17. 基于TopHat分割和曲线模型的三车道检测方法%Three-lane Detection Method Based on TopHat Segmentation and Curve Models

    Institute of Scientific and Technical Information of China (English)

    段建民; 战宇辰; 刘冠宇

    2016-01-01

    In order to solve problems in the process of traditional three-lane detection, such as low anti-interference capacity, inaccuracy in lane fitting, and error identification of side lane, a three-lane detection method was proposed in this paper based on TopHat segmentation and curve models. A lane segmentation algorithm using variable-kernel TopHat was proposed as image pre-processing, by using shape features and color features of lane markings. For lane detection, firstly, a vanish-point fitting method based on WLS ( weighted least squares ) was proposed as a constraint of Hough transform. Secondly, straight lines were clustered in polar coordinates by using DBSCAN ( density-based spatial clustering of applications with noise) , matching to a template. Then lane ROI ( region of interest) was made according to the straight-line template, and the lane was searched and fitted by using cubic curve. Finally, for uncertain side-lanes, a side-lane driving judgement method was proposed by using random seed. The algorithm has better performance in both detection rate and lane miss rate than traditional three-lane detection algorithms. Experiment verifies that the method has high accuracy and stability, and is useful for three-lane detection.%为了解决传统三车道检测过程中算法易受干扰、车道线拟合不准确、两侧车道误判等问题,提出了一种基于顶帽算法( TopHat)分割和曲线模型的三车道检测方法。利用车道线的形状和颜色特征,在图像预处理阶段提出了一种变内核TopHat的车道线分割算法。在车道线识别阶段,首先,提出了一种基于加权最小二乘法( weighted least squares,WLS)的消失点拟合方法以约束霍夫变换;其次,在极坐标中以DBSCAN( density-based spatial clustering of applications with noise)聚类法对直线聚类并匹配三车道模板;再次,以该模板为基础建立车道线感兴趣区,在每个感兴趣区内搜索并以三次曲线模型拟合车

  18. Profiling of Phenolic Compounds and Antioxidant Activity of Dry Extracts from the Selected Sorbus Species

    Directory of Open Access Journals (Sweden)

    Piotr Michel

    2012-03-01

    Full Text Available The antioxidant efficiency of dry extracts from inflorescences and/or leaves of seven Sorbus species was studied using four in vitro tests of SET (single electron transfer and HAT-type (hydrogen atom transfer mechanisms. The 70% methanol extracts and its diethyl ether, ethyl acetate, n-butanol and water fractions were tested in parallel with the phenolic standards, e.g., caffeic acid, quercetin, BHA, BHT, and TroloxÒ. The SET-type activity of the extracts depended primarily on the extraction solvent. The most valuable extracts were n-butanol and ethyl acetate ones, which activity was high in the DPPH (EC50 = 3.2–5.2 μg/mL, TEAC (2.8–4.0 mmol Trolox®/g, and FRAP (9.8–13.7 mmol Fe2+/g tests, and strongly correlated with the total phenolic levels (39.6–58.2% of gallic acid equivalents. The HPLC-PDA analysis of the extracts led to the identification of chlorogenic acid, isoquercitrin, hyperoside, rutin, quercetin 3-O-sophoroside, and sexangularetin 3-O-b-D-glucopyranoside as the main components. Apart from flavonoids and hydroxycinnamic acids, proanthocyanidins have also a significant impact on the SET-type activity. The HAT-reactivity of the extracts in the linoleic acid peroxidation test (IC50 = 36.9–228.3 μg/mL depended more strongly on the plant tissue than on the extraction solvent, and its correlation with the phenolic content was weak. Both SET and HAT-type activity of the most potent Sorbus extracts was comparable with the activity of the standards, indicating their great potential as effective sources for health products.

  19. Transcriptional activation of the Epstein-Barr virus latency C promoter after 5-azacytidine treatment: evidence that demethylation at a single CpG site is crucial.

    Science.gov (United States)

    Robertson, K D; Hayward, S D; Ling, P D; Samid, D; Ambinder, R F

    1995-01-01

    The Epstein-Barr Virus (EBV) latency C promoter (Cp) is the origin of transcripts for six viral proteins. The promoter is active in lymphoblastoid B-cell lines but silent in many EBV-associated tumors and tumor cell lines. In these latter cell lines, the viral episome is hypermethylated in the vicinity of this promoter. We show that in such a cell line (Rael, a Burkitt's lymphoma line), 5-azacytidine inhibits DNA methyltransferase, brings about demethylation of EBV genomes, activates Cp transcription, and induces the expression of EBNA-2. Investigation of the phenomenon demonstrates the importance of the methylation status of a particular CpG site for the regulation of the Cp: (i) genomic sequencing shows that this site is methylated when the Cp is inactive and is not methylated when the promoter is active; (ii) methylation or transition mutation at this site abolishes complex formation with a cellular binding activity (CBF2) as determined by electrophoretic mobility shift analyses, competition binding analyses, and DNase I footprinting; and (iii) a single C --> T transition mutation at this site is associated with a marked reduction (> 50-fold) of transcriptional activity in a reporter plasmid. Thus, the CBF2 binding activity is shown to be methylation sensitive and crucial to EBNA-2-mediated activation of the Cp. PMID:7565767

  20. Cause Analysis and Disposal Advice on Crack in Huzhun Second-tier Bridge Pier Tray and Top Hat%呼准二线桥墩托盘顶帽裂缝成因分析及处置意见

    Institute of Scientific and Technical Information of China (English)

    徐华鑫

    2014-01-01

    With No.1 bridge pier in the inner Mongolia Coal railway as background , based on top hat crack dis-tribution in bridge pier tray , digital resiliometer was used for detecting concrete strength in crack densely-strewn area, supersonic detector was used for detecting width and depth of crack , and finally ANSYS is applied for pre-stress analysis .Through analysis on crack distribution and results from ANSYS , some advices are put forward to strengthen the No .1 bridge pier .%以内蒙古地方铁路呼准运煤专用线1号桥墩为背景,根据桥墩顶帽托盘的裂缝分布情况,采用数显回弹仪测试裂缝分布严重区域的混凝土强度,用超声波检测仪对裂缝的宽度和深度做了检测,通过有限元软件ANSYS对出现裂缝的区域做了应力分析。根据现场观察到的裂缝分布情况和有限元分析的结果,提出了对1号墩的加固和处置意见。

  1. Mechanistic Variants in Gas-Phase Metal-Oxide Mediated Activation of Methane at Ambient Conditions.

    Science.gov (United States)

    Li, Jilai; Zhou, Shaodong; Zhang, Jun; Schlangen, Maria; Usharani, Dandamudi; Shaik, Sason; Schwarz, Helmut

    2016-09-01

    The C-H bond activation of methane mediated by a prototypical heteronuclear metal-oxide cluster, [Al2Mg2O5](•+), was investigated by using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) in conjunction with high-level quantum mechanical calculations. Experimentally, hydrogen-atom abstraction from methane by the cluster ion [Al2Mg2O5](•+) takes place at ambient conditions. As to the mechanism, according to our computational findings, both the proton-coupled electron transfer (PCET) and the conventional hydrogen-atom transfer (HAT) are feasible and compete with each other. This is in distinct contrast to the [XYO2](+) (X, Y = Mg, Al, Si) cluster oxide ions which activate methane exclusively via the PCET route (Li, J.; Zhou, S.; Zhang, J.; Schlangen, M.; Weiske, T.; Usharani, D.; Shaik, S.; Schwarz, H. J. Am. Chem. Soc. 2016, 138, 7973-7981). The electronic origins of the mechanistically rather complex reactivity scenarios of the [Al2Mg2O5](•+)/CH4 couple were elucidated. For the PCET mechanism, in which the Lewis acid-base pair [Al(+)-O(-)] of the cluster acts as the active site, a clear correlation has been established between the nature of the transition state, the corresponding barrier height, the Lewis acidity-basicity of the [M(+)-O(-)] unit, as well as the bond order of the M(+)-O(-) bond. Also addressed is the role of the spin and charge distributions of a terminal oxygen radical site in the direct HAT route. The knowledge of the factors that control the reactivity of PCET and HAT pathways not only deepens our mechanistic understanding of metal-oxide mediated C-H bond activation but may also provide guidance for the rational design of catalysts. PMID:27518766

  2. Acetylation of retinal histones in diabetes increases inflammatory proteins: effects of minocycline and manipulation of histone acetyltransferase (HAT) and histone deacetylase (HDAC).

    Science.gov (United States)

    Kadiyala, Chandra Sekhar Rao; Zheng, Ling; Du, Yunpeng; Yohannes, Elizabeth; Kao, Hung-Ying; Miyagi, Masaru; Kern, Timothy S

    2012-07-27

    Histone acetylation was significantly increased in retinas from diabetic rats, and this acetylation was inhibited in diabetics treated with minocycline, a drug known to inhibit early diabetic retinopathy in animals. Histone acetylation and expression of inflammatory proteins that have been implicated in the pathogenesis of diabetic retinopathy were increased likewise in cultured retinal Müller glia grown in a diabetes-like concentration of glucose. Both the acetylation and induction of the inflammatory proteins in elevated glucose levels were significantly inhibited by inhibitors of histone acetyltransferase (garcinol and antisense against the histone acetylase, p300) or activators of histone deacetylase (theophylline and resveratrol) and were increased by the histone deacetylase inhibitor, suberolylanilide hydroxamic acid. We conclude that hyperglycemia causes acetylation of retinal histones (and probably other proteins) and that the acetylation contributes to the hyperglycemia-induced up-regulation of proinflammatory proteins and thereby to the development of diabetic retinopathy.

  3. Calcium in pollen-pistil interaction in `Petunia hybrida Hat`. Pt. 3. Localization of Ca{sup 2+} ions and Ca{sup 2+}-ATPase in pollinated pistil

    Energy Technology Data Exchange (ETDEWEB)

    Bednarska, E.; Butowt, R. [Uniwersytet Mikolaja Kopernika, Torun (Poland)

    1995-12-31

    Studies were carried out of Ca{sup 2+} and Ca{sup 2+}-ATPase localization in pollinated (6 and 48 h after pollination) pistils of `Petunia hybrida`. The results were confronted with Ca{sup 2+} localization in mature pollen grain and in unpollinated pistil. It has been found that after pollination the number of Ca{sup 2+} sequestered in the stigmal exudate and in the sporoderm of the pollen grain gets lower. That phenomenon was associated with the appearance of a large number of Sb/Ca precipitates in the submembrane cytoplasm of the germinating pollen. In the vacuolized pollen grain, i.e. grown into a pollen tube, there were only a few precipitates. In the pollen tube, Ca{sup 2+} were found in the organelles of the tip cytoplasm and in the external pectin cell wall. Studies with the use of {sup 45}Ca{sup 2+} have revealed that the source of calcium ions incorporated into the pollen tube tip and its pectin wall is the transmitting tract of the style. In the transmitting tract overgrown with pollen tubes, Ca{sup 2+} were localized in the intercellular matrix and in the transmitting cell. Sb/Ca precipitates occurred in the nuclei, around the secretary vesicles and on the plasmalemma in the transverse walls region. Elevated Ca{sup 2+} level was found in degenerating cells (inhibited pollen tubes, transmitting cells, nucellar cells). The progressing degeneration process of the cells of the transmitting tract of the pollinated pistil was associated with a decrease in the activity of plasmalemma Ca{sup 2+}-ATPase. (author). 30 refs, 19 figs.

  4. Sex difference and menstrual cycle effects on semantic priming and rememberingAnlamsal hazırlama ve hatırlamada cinsiyet farkı ve menstural dönem etkileri

    Directory of Open Access Journals (Sweden)

    Evrim Gülbetekin

    2015-02-01

    fluctuate across the menstrual cycle. The findings were discussed in the context of the negative effects of increasing luteinizing hormone (LH levels on attentional and executive functions in both ovulatory phase and Alzheimer’s disease. ÖzetAmaç: Kadınların ve erkeklerin bazı bilişsel işlemlerde ve hemisferik özelleşmelerde farklılık gösterdiği; buna karşın, cinsiyet farklılıklarına ilişkin çalışmaların her zaman çok tutarlı olmadığı bilinmektedir. Son dönemlerde yapılan çalışmalar, kadınlardaki bilişsel becerilerin menstural döneme bağlı olarak dalgalanma gösterebildiğine işaret etmiştir. Sunulan çalışmada erkeklerin ve farklı menstural dönemdeki kadınların (yumurtlama ve mensturasyon anlamsal hazırlama (AH ve hatırlama görevindeki peformansları yönünden farklılık gösterip göstermediğini incelemek amaçlanmıştır. Ayrıca AH görevinde cinsiyete özgü hemisferik özelleşme olup olmadığı incelenmiştir.Yöntem: Çalışmaya 72 kadın ve 29 erkek üniversite öğrencisi katılmıştır. AH görevi için katılımcılara arka arkaya iki resim gösterilmiştir. Görsel-yarı alan tekniği kullanılarak ve deney gruplarına uygun olarak ilk resim sol görsel alanda, sağ görsel alanda ya da merkezde100ms sunulmuş; katılımcılardan merkezde sunulan birinci resimle ikinci resmin ilişkili olup olmadığını belirtmeleri istenmiştir. AH görevinin ardından katılımcılara deneydeki uyarıcıların bir listesi verilmiş ve bunun içinden hatırladıklarını bir dakikalık sürede işartlemeleri istenmiştir.Bulgular: Tüm gruplarda AH etkisinin olduğu; ancak bu göreve ilişkin bir hemisferik özelleşmenin olmadığı bulunmuştur. Erkekler ilişkili resimleri yumurtlama dönemindeki kadınlardan daha hızlı değerlendirirken, mensturasyon dönemindeki kadınlarla böyle bir farklılık gözlenmemiştir. Benzer şekilde erkeklerin hatırladıkları genel uyarıcı ve ilişkisiz uyarıcı say

  5. Profiling of Phenolic Compounds and Antioxidant Activity of Dry Extracts from the Selected Sorbus Species

    OpenAIRE

    Piotr Michel; Olszewska, Monika A.; Anna Presler

    2012-01-01

    The antioxidant efficiency of dry extracts from inflorescences and/or leaves of seven Sorbus species was studied using four in vitro tests of SET (single electron transfer) and HAT-type (hydrogen atom transfer) mechanisms. The 70% methanol extracts and its diethyl ether, ethyl acetate, n-butanol and water fractions were tested in parallel with the phenolic standards, e.g., caffeic acid, quercetin, BHA, BHT, and TroloxÒ. The SET-type activity of the extracts depended primarily on the extractio...

  6. Structure-thermodynamics-antioxidant activity relationships of selected natural phenolic acids and derivatives: an experimental and theoretical evaluation.

    Science.gov (United States)

    Chen, Yuzhen; Xiao, Huizhi; Zheng, Jie; Liang, Guizhao

    2015-01-01

    Phenolic acids and derivatives have potential biological functions, however, little is known about the structure-activity relationships and the underlying action mechanisms of these phenolic acids to date. Herein we investigate the structure-thermodynamics-antioxidant relationships of 20 natural phenolic acids and derivatives using DPPH• scavenging assay, density functional theory calculations at the B3LYP/6-311++G(d,p) levels of theory, and quantitative structure-activity relationship (QSAR) modeling. Three main working mechanisms (HAT, SETPT and SPLET) are explored in four micro-environments (gas-phase, benzene, water and ethanol). Computed thermodynamics parameters (BDE, IP, PDE, PA and ETE) are compared with the experimental radical scavenging activities against DPPH•. Available theoretical and experimental investigations have demonstrated that the extended delocalization and intra-molecular hydrogen bonds are the two main contributions to the stability of the radicals. The C = O or C = C in COOH, COOR, C = CCOOH and C = CCOOR groups, and orthodiphenolic functionalities are shown to favorably stabilize the specific radical species to enhance the radical scavenging activities, while the presence of the single OH in the ortho position of the COOH group disfavors the activities. HAT is the thermodynamically preferred mechanism in the gas phase and benzene, whereas SPLET in water and ethanol. Furthermore, our QSAR models robustly represent the structure-activity relationships of these explored compounds in polar media.

  7. NLO Jet Physics with BlackHat

    Energy Technology Data Exchange (ETDEWEB)

    Berger, C.F.; /MIT, LNS; Bern, Z.; /UCLA; Dixon, L.J.; /SLAC; Cordero, F.Febres; /Simon Bolivar U.; Forde, D.; /CERN /NIKHEF, Amsterdam; Gleisberg, T.; /SLAC; Ita, H.; /UCLA; Kosower, D.A.; /DAPNIA, Saclay; Maitre, D.; /Durham U.

    2010-02-15

    We present several results obtained using the BLACKHAT next-to-leading order QCD program library, in conjunction with SHERPA. In particular, we present distributions for vector boson plus 1,2,3-jet production at the Tevatron and at the asymptotic running energy of the Large Hadron Collider, including new Z + 3-jet distributions. The Z + 2-jet predictions for the second-jet P{sub T} distribution are compared to CDF data. We present the jet-emission probability at NLO in W + 2-jet events at the LHC, where the tagging jets are taken to be the ones furthest apart in pseudorapidity. We analyze further the large left-handed W{sup {+-}} polarization, identified in our previous study, for W bosons produced at high P{sub T} at the LHC.

  8. Computer Security: White hats for CERN

    CERN Multimedia

    Stefan Lueders, Computer Security Team

    2016-01-01

    CERN is under attack. Permanently. Even right now. In particular, the CERN web environment, with its thousands of websites and millions of webpages, is a popular target for evil-doers as well as for security researchers.   Usually, their attacks are unsuccessful and fade away over time. Sometimes, however, they are successful and manage to break into a CERN website or web server… It is imperative that we learn about our weaknesses before others do – and fix them! Hackers with bad intentions are usually named “black hats” as they misuse their power to cause destruction or downtime via any weakness they can find. “Grey hats” are more moderate and might just have some fun with the weaknesses they find, for example by putting naked teddy bears or a personal message (such as “I hacked U”) on the compromised website. Last but not least, “white hats” report their findings directly to us and suggest that...

  9. Getting started with Red Hat Enterprise virtualization

    CERN Document Server

    Subramanian, Pradeep

    2014-01-01

    If you are a system administrator who is interested in implementing and managing open source virtualization infrastructures, this is the book for you. A basic knowledge of virtualization and basic Linux command line experience is needed.

  10. Advanced nursing practice: old hat, new design.

    Science.gov (United States)

    De Grasse, C; Nicklin, W

    2001-01-01

    Advanced practice nurses positively impact the delivery of healthcare and client outcomes. However, in the past these positions have been seen to have variable value and were often vulnerable during budget cuts. Lack of a clear advanced nursing practice (ANP) framework probably contributed to the compromised effectiveness of these roles and evolution of roles with different titles, scopes of practice and reporting structures. To build the foundation for developing an ANP framework, a task force at The Ottawa Hospital (TOH) conducted a literature review related to ANP roles and completed a review of all clinical nursing roles at TOH. In addition, focus groups with nurses and other health professionals elicited ANP perceptions. The ANP framework includes a standardized job description that details competencies under five role components: clinical practice; consultation; research; education; and, leadership. Recommendations for assessment, implementation and evaluation of ANP roles are identified. The process undertaken by our ANP task force proved to be thorough and sound in developing a framework within which to move forward with ANP role implementation throughout TOH. This article, describing the process, may assist other organizations in defining ANP roles to better meet patient needs in changing health care environments. PMID:11803945

  11. Hats off to CERN's Master of Apprenticeships!

    CERN Multimedia

    2004-01-01

    Roland Gay of the HR Department (at right) recently received a special diploma from the Geneva Industrial Union (UIG). Presented by Carlo Lamprecht, Head of the Department of Economy, Employment and External Affairs of the State of Geneva, the diploma was awarded in recognition of the 199 CERN apprentices Roland has guided through the Certificat Fédéral de Capacité (CFC), an end-of-apprenticeship certificate awarded by the Cantonal authorities. Roland will be retiring in December 2004 after 37 years of service, 32 of which he spent in the role of apprenticeship supervisor.

  12. ALICE doffs hat to two companies

    CERN Multimedia

    2007-01-01

    During the fifth annual ALICE Industrial Awards ceremony, the ALICE Collaboration honoured two companies for their outstanding contributions to the construction of the experiment.For the past five years, the ALICE collaboration has been presenting its industrial partners with awards for meeting demanding or unusual requirements, for excellence in design or execution, for delivery on-time and on-budget and for outstanding cooperation. This year, on 9 March, ALICE presented awards to two companies for their exceptional performance. From left to right: Kees Oskamp (ALICE SSD), Arie de Haas (ALICE SSD), Gert-Jan Nooren (ALICE SSD), Shon Shmuel (FIBERNET), Yehuda Mor-Yosef (FIBERNET), Hans Boggild (ALICE), Jurgen Schukraft (ALICE Spokesperson), Catherine Decosse (ALICE) and Jean-Robert Lutz (ALICE SSD). FIBERNET Ltd., based in Yokneam, Israel, was rewarded for the excellent and timely assembly of the Silicon Strip Detector boards (SSD) of the Inner Tracking System with cable connections. Special low-mass cables, ...

  13. Shaft Grouting HATS2A Hong Kong

    OpenAIRE

    Strøm, Henrik

    2011-01-01

    In this thesis I have been following 5 grouting rounds at Cyberport shaft and 4 grouting rounds at Sandy Bay shaft.There were some communication problems between the grouting team and the geologists, resulting in missing water inflow measurements.The rock quality was very poor (Q-value 0.1 – 1), with coarse ash tuff as the most common rock mass in Cyberport, and rhyolitic tuff as the most common rock mass in Sandy Bay. The Q-values were below 1, with Cyberport just a bit higher than Sandy Bay...

  14. Switching Hats: From Accessibility to Possibility

    Directory of Open Access Journals (Sweden)

    Sarah McGann

    2009-11-01

    Full Text Available Neil is a sporty, outdoorsy sort of bloke. He spends verylittle time at home, preferring to golf, surf, go to the footy and hang out with his mates: You can tell just by looking inside his house—a huge TV in the darkened lounge, and golf equipment, surf boards and motorbike gear fill up the room. That was before last October. Now, in June, Neil is a paraplegic, his house is inaccessible and his boys-toys are in the way. For Neil, his home, previously an inwardly focused place to sleep and store, will become the centre of his world (when he can eventually get into it. Initially, accessibility is the key problem to be solved. To this end the architectural advisor from the rehabilitation unit proposed formulaic adjustments to the bathroom to allow for wheelchair access. However, accessibility is only one facet of the problem. This environment, relatively unimportant before,now needs to enable and inspire the occupant both physically and emotionally. As physical abilities dramatically change the spatial practices of everyday life also change.The home environment is ever more important to support and help heal emotional scarring after a life-changing event.In the context of shorter hospital and rehabilitation stays,the home provides a vital extension to the healthcare system. Therefore it is important that architectural advice given to enable this move considers the holistic qualities ofdesign thinking rather than be restricted to short-term solutions.

  15. Hats off to the particle suppliers

    CERN Multimedia

    Rolf Heuer

    2010-01-01

    A couple of weeks into the LHC’s first high energy physics run, and we’ve already got an impressive story to tell. Long fills for physics are becoming routine, luminosity scans have increased the collision rate. The operators are becoming adept at squeezing the beams ever smaller, and higher intensity studies are progressing well. With the experiments, it’s the same story.   Following the plots that the spokespersons were able to show on 30 March after just one hour of running, the experiments have already made significant inroads into re-measuring all the Standard Model parameters necessary to ensure that they fully understand their detectors before any new discoveries can be announced. It’s impressive stuff, and the attention is rightly on the LHC and its experiments. But we shouldn’t lose sight of the fact that all this relies on the seamless operation of many other systems. Starting from a deceptively simple bottle of hydrogen, an LHC proton ...

  16. Habitat Testbed (HaT) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Goals of the DSH Testbed include:Function as a habitat systems integrator and technology pull across many domainsDevelop and integrate software-based models of...

  17. Epigenetic regulation of proliferation and invasion in hepatocellular carcinoma cells by CBP/p300 histone acetyltransferase activity.

    Science.gov (United States)

    Inagaki, Yuji; Shiraki, Katsuya; Sugimoto, Kazushi; Yada, Takazumi; Tameda, Masahiko; Ogura, Suguru; Yamamoto, Norihiko; Takei, Yoshiyuki; Ito, Masaaki

    2016-02-01

    Altered epigenetic control of gene expression plays a substantial role in tumor development and progression. Accumulating studies suggest that somatic mutations of CREB binding proteins (CBP)/p300 occur in some cancer cells. CBP/p300 possess histone acetyltransferase (HAT) activity, and are involved in many cellular processes. In this study, we investigated the expression and functional role of CBP/p300 in hepatocellular carcinoma (HCC) using the specific inhibitor C646 of CBP/p300 HAT activity. We examined its effect on several apoptosis-related proteins and invasion-related genes. The results showed that CBP/p300 were highly expressed in HCC tissues and that expression of p300, but not of CBP, was strongly correlated with the malignant character of HCC. C646 inhibited proliferation of HCC cell lines in a dose dependent manner. C646 significantly augmented TRAIL-induced apoptotic sensitivity, which was accompanied by reduced levels of survivin, in HepG2, HLE and SK-HEP1 cells. C646 significantly inhibited invasion of Huh7, HLE and SK-HEP1 cells. The level of matrix metallopeptidase 15 (MMP15) mRNA expression was significantly reduced, whereas the level of laminin alpha 3 (LAMA3) and secreted phosphoprotein 1 (SPP1) mRNA expression was significantly increased in Huh7 cells following exposure to C646. In conclusion, our results suggest that CBP/p300 HAT activity has an important role in malignant transformation, proliferation, apoptotic sensitivity and invasion in HCC. CBP/p300 could be a promising therapeutic target in HCC. PMID:26676548

  18. Activation of GATA4 gene expression at the early stage of cardiac specification

    Directory of Open Access Journals (Sweden)

    Ayse eYilbas

    2014-03-01

    Full Text Available Currently, there are no effective treatments to directly repair damaged heart tissue after cardiac injury since existing therapies focus on rescuing or preserving reversibly damaged tissue. Cell-based therapies using cardiomyocytes generated from stem cells present a promising therapeutic approach to directly replace damaged myocardium with new healthy tissue. However, the molecular mechanisms underlying the commitment of stem cells into cardiomyocytes are not fully understood and will be critical to guide this new technology into the clinic. Since GATA4 is a critical regulator of cardiac differentiation, we examined the molecular basis underlying the early activation of GATA4 gene expression during cardiac differentiation of pluripotent stem cells. Our studies demonstrate the direct involvement of histone acetylation and transcriptional coactivator p300 in the regulation of GATA4 gene expression. More importantly, we show that histone acetyltransferase (HAT activity is important for GATA4 gene expression with the use of curcumin, a HAT inhibitor. In addition, the widely used histone deacetylase inhibitor valproic acid enhances both histone acetylation and cardiac specification.

  19. Activation of GATA4 gene expression at the early stage of cardiac specification

    Science.gov (United States)

    Yilbas, Ayse; Hamilton, Alison; Wang, Yingjian; Mach, Hymn; Lacroix, Natascha; Davis, Darryl; Chen, Jihong; LI, Qiao

    2014-03-01

    Currently, there are no effective treatments to directly repair damaged heart tissue after cardiac injury since existing therapies focus on rescuing or preserving reversibly damaged tissue. Cell-based therapies using cardiomyocytes generated from stem cells present a promising therapeutic approach to directly replace damaged myocardium with new healthy tissue. However, the molecular mechanisms underlying the commitment of stem cells into cardiomyocytes are not fully understood and will be critical to guide this new technology into the clinic. Since GATA4 is a critical regulator of cardiac differentiation, we examined the molecular basis underlying the early activation of GATA4 gene expression during cardiac differentiation of pluripotent stem cells. Our studies demonstrate the direct involvement of histone acetylation and transcriptional coactivator p300 in the regulation of GATA4 gene expression. More importantly, we show that histone acetyltransferase (HAT) activity is important for GATA4 gene expression with the use of curcumin, a HAT inhibitor. In addition, the widely used histone deacetylase inhibitor valproic acid enhances both histone acetylation and cardiac specification.

  20. Cihan Harbinin Karanlığında Aydınlığı Hatırla(tmak: Ömer Seyfettin’in Kaleminden Kahramanlara Dair

    Directory of Open Access Journals (Sweden)

    Melih Erzen

    2014-06-01

    Full Text Available I. Dünya Savaşı, Avrupa ülkelerinin ekonomik çıkarları ve anlaşmazlıklarından beslenen bir savaş olup büyük yıkımları da beraberinde getirmiştir. Söz konusu tarihlerde zaten yeterince müşkül durumda bulunan Osmanlı Devleti, müdahil olduğu bu savaş dolayısıyla daha da büyük kayıplar vermiştir. Elbette ki bir savaşta alınan zafer yahut yenilgiler, savaşan ülkenin yalnızca askeri birliklerini değil bütün bir halkını ilgilendirmekte ve etkilemektedir. Toplumun birer ferdi olarak hemen her sanatçı bu tür büyük olaylardan etkilendiği gibi ayrıca toplumun sözcülüğünü üstlenmek adına yola çıkan sanatçılar da bulunmaktadır. Sosyolojik yönü bulunan edebiyat için de durumun böyle olduğunu görürüz. Edebi eserler üzerine yapılan incelemeler, bu metinlerin zaman zaman toplum meselelerini takip etmek veya toplumun ahvalini anlayabilmek açısından imkân tanıdığını kanıtlamıştır. Nitekim Türk toplumunu derinden etkileyen I. Dünya Savaşı’nın yansımalarına da edebi eserler üzerinden ulaşmanın mümkün olduğu söylenebilir. Ömer Seyfettin’in birçoğunu 1917-1918 yılları arasında Yeni Mecmua’da yayımladığı öyküleri bu duruma iyi bir örnek teşkil eder. “Eski Kahramanlar” başlığı altındaki hikâyelerinde eski zaman dilimlerini esas alarak kahraman tipleri resmeden Ömer Seyfettin, milletinin taşıdığı cevherleri hatırlatmak suretiyle topluma ve askerlere moral vermeyi amaçlar. Onun yine aynı tarihlerde “Yeni Kahramanlar” üst başlığı ile yazdığı birkaç hikâye ise Çanakkale Savaşı’nın olumlu havasını ve başarısını yansıtmaya yöneliktir. Bu çalışmanın amacı, Ömer Seyfettin’in “Eski Kahramanlar” ve “Yeni Kahramanlar” üst başlıkları altında yayımlanan hikâyelerinden yola çıkarak “kahraman” tanımlaması içerisine oturtulan hikâye kişilerini ve bu kişilerin vasıflarını incelemektir.

  1. Multistability and Instability of Neural Networks With Discontinuous Nonmonotonic Piecewise Linear Activation Functions.

    Science.gov (United States)

    Nie, Xiaobing; Zheng, Wei Xing

    2015-11-01

    In this paper, we discuss the coexistence and dynamical behaviors of multiple equilibrium points for recurrent neural networks with a class of discontinuous nonmonotonic piecewise linear activation functions. It is proved that under some conditions, such n -neuron neural networks can have at least 5(n) equilibrium points, 3(n) of which are locally stable and the others are unstable, based on the contraction mapping theorem and the theory of strict diagonal dominance matrix. The investigation shows that the neural networks with the discontinuous activation functions introduced in this paper can have both more total equilibrium points and more locally stable equilibrium points than the ones with continuous Mexican-hat-type activation function or discontinuous two-level activation functions. An illustrative example with computer simulations is presented to verify the theoretical analysis.

  2. Reversible histone acetylation/deacetylation modification by p300 and HDAC3 is involved in the regulation of IL-18 promoter activity

    Institute of Scientific and Technical Information of China (English)

    SUN Haijing; LU Jun; XU Xin; WEI Liang; HUANG Baiqu

    2004-01-01

    Interleukin-18 (IL-18) is a pleiotropic cytokine involved in the development of T helper type 1 (Thl) cells, and it plays important roles in regulation of both the innate and acquired immune responses. The aim of this study was to elucidate whether the reversible histone acetylation/ deacetylation modification participates in the regulation of IL-18 transcription expression. The transcription coactivator p300 containing the histone acetyltransferase (HAT) activity, and the histone deacetylase 3 (HDAC3) were used in this study to analyze the effect of this modification in the regulation of mouse IL-18 gene. The results demonstrate that transfection of p300-expression plasmid promotes the endogenous IL-18 mRNA synthesis in J774 cells, and stimulates the activation of IL-18 promoter. It has been found that this stimulating effect of p300 was reversed by HDAC3, indicating the involvement of the reversible histone acetylation/deacetylation modification in IL-18 regulation. Furthermore, the data show that the HAT activity of p300 was essential to its function in activating IL-18 promoter. In addition, p300 was shown to be able to work synergistically with the transcription factor c-Fos on activation of IL-18 promoter and this effect could also be impaired by HDAC3. Results presented in this paper indicate that the reversible histone acetylation/deacetylation modification plays an important role in the transcriptional regulation of IL-18.

  3. Activation of pluripotency genes in human fibroblast cells by a novel mRNA based approach.

    Directory of Open Access Journals (Sweden)

    Jordan R Plews

    Full Text Available BACKGROUND: Several methods have been used to induce somatic cells to re-enter the pluripotent state. Viral transduction of reprogramming genes yields higher efficiency but involves random insertions of viral sequences into the human genome. Although induced pluripotent stem (iPS cells can be obtained with the removable PiggyBac transposon system or an episomal system, both approaches still use DNA constructs so that resulting cell lines need to be thoroughly analyzed to confirm they are free of harmful genetic modification. Thus a method to change cell fate without using DNA will be very useful in regenerative medicine. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we synthesized mRNAs encoding OCT4, SOX2, cMYC, KLF4 and SV40 large T (LT and electroporated them into human fibroblast cells. Upon transfection, fibroblasts expressed these factors at levels comparable to, or higher than those in human embryonic stem (ES cells. Ectopically expressed OCT4 localized to the cell nucleus within 4 hours after mRNA introduction. Transfecting fibroblasts with a mixture of mRNAs encoding all five factors significantly increased the expression of endogenous OCT4, NANOG, DNMT3β, REX1 and SALL4. When such transfected fibroblasts were also exposed to several small molecules (valproic acid, BIX01294 and 5'-aza-2'-deoxycytidine and cultured in human embryonic stem cell (ES medium they formed small aggregates positive for alkaline phosphatase activity and OCT4 protein within 30 days. CONCLUSION/SIGNIFICANCE: Our results demonstrate that mRNA transfection can be a useful approach to precisely control the protein expression level and short-term expression of reprogramming factors is sufficient to activate pluripotency genes in differentiated cells.

  4. Development of a Safeguard System Using an Episomal Mammalian Artificial Chromosome for Gene and Cell Therapy

    Science.gov (United States)

    Uno, Narumi; Uno, Katsuhiro; Komoto, Shinya; Suzuki, Teruhiko; Hiratsuka, Masaharu; Osaki, Mitsuhiko; Kazuki, Yasuhiro; Oshimura, Mitsuo

    2015-01-01

    The development of a safeguard system to remove tumorigenic cells would allow safer clinical applications of stem cells for the treatment of patients with an intractable disease including genetic disorders. Such safeguard systems should not disrupt the host genome and should have long-term stability. Here, we attempted to develop a tumor-suppressing mammalian artificial chromosome containing a safeguard system that uses the immune rejection system against allogeneic tissue from the host. For proof-of-concept of the safeguard system, B16F10 mouse melanoma cells expressing the introduced H2-K(d) major histocompatibility complex (MHC class I)-allogenic haplotype were transplanted into recipient C57BL/6J mice expressing MHC H2-K(b). Subcutaneous implantation of B16F10 cells into C57BL/6J mice resulted in high tumorigenicity. The volume of tumors derived from B16F10 cells expressing allogenic MHC H2-K(d) was decreased significantly (P < 0.01). Suppression of MHC H2-K(d)-expressing tumors in C57BL/6J mice was enhanced by immunization with MHC H2-K(d)-expressing splenocytes (P < 0.01). These results suggest that the safeguard system is capable of suppressing tumor formation by the transplanted cells. PMID:26670279

  5. Sonodelivery Facilitates Sustained Luciferase Expression from an Episomal Vector in Skeletal Muscle

    Directory of Open Access Journals (Sweden)

    Manoel Figueiredo Neto

    2015-07-01

    Full Text Available Successful gene delivery to skeletal muscle is a desirable goal, not only for treating muscle diseases, but also for immunization, treatment of metabolic disorders, and/or delivering gene expression that can treat systemic conditions, such as bone metastatic cancer, for example. Although naked DNA uptake into skeletal muscle is possible, it is largely inefficient in the absence of additional chemical or physical delivery methods. We describe a system for delivery of non-viral or plasmid DNA to skeletal muscle using ultrasound-assisted sonoporation of a nanoplex combining plasmid DNA and a branched polymer based on poly(cyclooctene-graft-oligopeptide. The materials and methods described herein promise to advance the field of sonodelivery and of gene delivery to muscle for therapeutic applications since a simple system is presented that enables long-term gene expression in vivo with the promise of a minimal inflammatory gene expression profile.

  6. A novel high-throughput activity assay for the Trypanosoma brucei editosome enzyme REL1 and other RNA ligases

    Science.gov (United States)

    Zimmermann, Stephan; Hall, Laurence; Riley, Sean; Sørensen, Jesper; Amaro, Rommie E.; Schnaufer, Achim

    2016-01-01

    The protist parasite Trypanosoma brucei causes Human African trypanosomiasis (HAT), which threatens millions of people in sub-Saharan Africa. Without treatment the infection is almost always lethal. Current drugs for HAT are difficult to administer and have severe side effects. Together with increasing drug resistance this results in urgent need for new treatments. T. brucei and other trypanosomatid pathogens require a distinct form of post-transcriptional mRNA modification for mitochondrial gene expression. A multi-protein complex called the editosome cleaves mitochondrial mRNA, inserts or deletes uridine nucleotides at specific positions and re-ligates the mRNA. RNA editing ligase 1 (REL1) is essential for the re-ligation step and has no close homolog in the mammalian host, making it a promising target for drug discovery. However, traditional assays for RELs use radioactive substrates coupled with gel analysis and are not suitable for high-throughput screening of compound libraries. Here we describe a fluorescence-based REL activity assay. This assay is compatible with a 384-well microplate format and sensitive, satisfies statistical criteria for high-throughput methods and is readily adaptable for other polynucleotide ligases. We validated the assay by determining kinetic properties of REL1 and by identifying REL1 inhibitors in a library of small, pharmacologically active compounds. PMID:26400159

  7. SU-E-J-144: Low Activity Studies of Carbon 11 Activation Via GATE Monte Carlo

    International Nuclear Information System (INIS)

    Purpose: To investigate the behavior of a Monte Carlo simulation code with low levels of activity (∼1,000Bq). Such activity levels are expected from phantoms and patients activated via a proton therapy beam. Methods: Three different ranges for a therapeutic proton radiation beam were examined in a Monte Carlo simulation code: 13.5, 17.0 and 21.0cm. For each range, the decay of an equivalent length11C source and additional sources of length plus or minus one cm was studied in a benchmark PET simulation for activities of 1000, 2000 and 3000Bq. The ranges were chosen to coincide with a previous activation study, and the activities were chosen to coincide with the approximate level of isotope creation expected in a phantom or patient irradiated by a therapeutic proton beam. The GATE 7.0 simulation was completed on a cluster node, running Scientific Linux Carbon 6 (Red Hat©). The resulting Monte Carlo data were investigated with the ROOT (CERN) analysis tool. The half-life of11C was extracted via a histogram fit to the number of simulated PET events vs. time. Results: The average slope of the deviation of the extracted carbon half life from the expected/nominal value vs. activity showed a generally positive value. This was unexpected, as the deviation should, in principal, decrease with increased activity and lower statistical uncertainty. Conclusion: For activity levels on the order of 1,000Bq, the behavior of a benchmark PET test was somewhat unexpected. It is important to be aware of the limitations of low activity PET images, and low activity Monte Carlo simulations. This work was funded in part by the Philips corporation

  8. Semisynthesis and quantitative structure-activity relationship (QSAR) study of some cholesterol-based hydrazone derivatives as insecticidal agents.

    Science.gov (United States)

    Yang, Chun; Shao, Yonghua; Zhi, Xiaoyan; Huan, Qu; Yu, Xiang; Yao, Xiaojun; Xu, Hui

    2013-09-01

    In continuation of our program aimed at the discovery and development of natural-product-based insecticidal agents, four series of novel cholesterol-based hydrazone derivatives were synthesized, and their insecticidal activity was tested against the pre-third-instar larvae of oriental armyworm, Mythimna separata (Walker) in vivo at 1mg/mL. All the derivatives showed the better insecticidal activity than their precursor cholesterol. Quantitative structure-activity relationship (QSAR) model demonstrated that six descriptors such as RDF085v, Mor06u, Mor11u, Dv, HATS0v and H-046, are likely to influence the insecticidal activity of these compounds. Among them, two important ones are the Mor06u and RDF085v. PMID:23891182

  9. Interaction of Papillomavirus E2 Protein with the Brm Chromatin Remodeling Complex Leads to Enhanced Transcriptional Activation▿

    OpenAIRE

    Ajay Kumar, R.; Naidu, Samisubbu R.; Wang, Xiaoyu; Imbalzano, Anthony N.; Androphy, Elliot J.

    2006-01-01

    Papillomavirus E2 is a sequence-specific DNA binding protein that regulates transcription and replication of the viral genome. The transcriptional activities of E2 are typically evaluated by transient transfection of nonreplicating E2-dependent reporters. We sought to address whether E2 activates transcription in an episomal context and its potential interaction with the chromatin remodeling proteins. Using an Epstein-Barr virus-based episomal reporter, we demonstrate that E2 stimulates trans...

  10. 1,5-Diarylpyrazole and vanillin hybrids: Synthesis, biological activity and DFT studies.

    Science.gov (United States)

    Hernández-Vázquez, Eduardo; Castañeda-Arriaga, Romina; Ramírez-Espinosa, Juan José; Medina-Campos, Omar Noel; Hernández-Luis, Francisco; Chaverri, José Pedraza; Estrada-Soto, Samuel

    2015-07-15

    Herein, we report the design and synthesis of 13 diarylpyrazole hybrids with vanillin constructed as dual compounds against oxidative stress and diabetes. Compounds were tested in two different antioxidant assays. It was found that all compounds showed an important antioxidant activity in both DPPH and ORAC models and the activity was even more remarkable than vanillin. In addition, the hypoglycemic effect of compounds 1, 2, 4 and 12 was evaluated. Interestingly, compound 1 had the most potent hypoglycemic effect with a glycemia reduction of 71%, which was higher than rimonabant. Finally, a DFT study to propose a reasonable antioxidant mechanism is detailed. Both thermodynamic and kinetic studies indicated that the most feasible mechanism consists in the HAT abstraction of the phenolic hydrogen due to the formation of an stable transition state through the most rapid and exergonic path, while the SPLET mechanism is the most significant at higher pH values.

  11. Cognitive Approach Based User Node Activity Monitoring for Intrusion Detection in Wireless Networks

    Directory of Open Access Journals (Sweden)

    G Sunilkumar

    2012-03-01

    Full Text Available Cognitive networks are the solution for the problems existing on the current networks. Users maintain integrity of the networks and user node activity monitoring is required for provision of security. Cognitive Networks discussed in this paper not only monitor user node activity but also take preventive measures if user node transactions are malicious. The intelligence in cognitive engine is realized using self-organizing maps (CSOMs. Gaussian and Mexican Hat neighbor learning functions have been evaluated to realize CSOMs. Experimental study proves the efficiency of Gaussian Learning function is better for cognition engine. The cognition engine realized is evaluated for malicious node detection in dynamic networks. The proposed concept results in better Intrusion detection rate as compared to existing approaches.

  12. Görsellerle Desteklenmiş Altı Şapka Düşünme Tekniğinin Öğrencilerin Konuşma Becerilerini Geliştirmesine Etkisi Six Thinking Hats Technique Supported Visuals Effects of Students' Speaking Skills Develop

    Directory of Open Access Journals (Sweden)

    Salih ORHAN

    2012-09-01

    Full Text Available to express oneself to communicate as a society to provide others. Inthis sense, individuals benefit from the ability to talk in daily life themost. Speaking a language skill can be developed which are used in avariety of methods to be used more effectively.The main objective of this study, elementary school studentsimprove their speaking skills supported by visuals than the traditionalmethod to determine the effect of six hat thinking techniques. Theprimary purpose of research 8th grade students for a period of fourweeks 'of Science and Technology' theme applied The data "SpeakingObservation Form" (Orhan, 2010 collected the data. Visuals supportedby the experimental group, while speaking activities, speaking in thecontrol group were carried out according to conventional method. Inthis context, information about the method, first given to students inthe experimental group, how to implement this method, the researcherexplained to the students by students. Then, for each color of the sixhat thinking techniques were made in the speech handed out picturesto students. The data were evaluated with SPSS 19.0, to compare withthose of the pre-test and post-test "for the measurements associatedwith the Wilcoxon signed Ranks Test" was used. As a result 'speechrules, Effective use of voice and body language, be prepared to makespeeches, their speech evaluation' goals and achievements, such as thedevelopment of speech in the Turkish Course Programme of theexperimental group students was found to be more successful than thecontrol group students and and a variety of applications related toproposing and speaking skills teachers can use this method unlessotherwise indicated. Eğitimin en temel hedeflerinden biri de insanın kendisini ifade edebilmesini ve toplumsal bir varlık olarak toplumun diğer bireyleriyle iletişim kurabilmesini sağlamaktır. Bu anlamda bireyler günlük hayatta en çok konuşma becerisinden faydalanmaktadırlar. Geliştirilebilir bir

  13. Activation of phonological competitors in visual search.

    Science.gov (United States)

    Görges, Frauke; Oppermann, Frank; Jescheniak, Jörg D; Schriefers, Herbert

    2013-06-01

    Recently, Meyer, Belke, Telling and Humphreys (2007) reported that competitor objects with homophonous names (e.g., boy) interfere with identifying a target object (e.g., buoy) in a visual search task, suggesting that an object name's phonology becomes automatically activated even in situations in which participants do not have the intention to speak. The present study explored the generality of this finding by testing a different phonological relation (rhyming object names, e.g., cat-hat) and by varying details of the experimental procedure. Experiment 1 followed the procedure by Meyer et al. Participants were familiarized with target and competitor objects and their names at the beginning of the experiment and the picture of the target object was presented prior to the search display on each trial. In Experiment 2, the picture of the target object presented prior to the search display was replaced by its name. In Experiment 3, participants were not familiarized with target and competitor objects and their names at the beginning of the experiment. A small interference effect from phonologically related competitors was obtained in Experiments 1 and 2 but not in Experiment 3, suggesting that the way the relevant objects are introduced to participants affects the chances of observing an effect from phonologically related competitors. Implications for the information flow in the conceptual-lexical system are discussed.

  14. Multistability of memristive Cohen-Grossberg neural networks with non-monotonic piecewise linear activation functions and time-varying delays.

    Science.gov (United States)

    Nie, Xiaobing; Zheng, Wei Xing; Cao, Jinde

    2015-11-01

    The problem of coexistence and dynamical behaviors of multiple equilibrium points is addressed for a class of memristive Cohen-Grossberg neural networks with non-monotonic piecewise linear activation functions and time-varying delays. By virtue of the fixed point theorem, nonsmooth analysis theory and other analytical tools, some sufficient conditions are established to guarantee that such n-dimensional memristive Cohen-Grossberg neural networks can have 5(n) equilibrium points, among which 3(n) equilibrium points are locally exponentially stable. It is shown that greater storage capacity can be achieved by neural networks with the non-monotonic activation functions introduced herein than the ones with Mexican-hat-type activation function. In addition, unlike most existing multistability results of neural networks with monotonic activation functions, those obtained 3(n) locally stable equilibrium points are located both in saturated regions and unsaturated regions. The theoretical findings are verified by an illustrative example with computer simulations.

  15. Substrate-dependent activation of the Vibrio cholerae vexAB RND efflux system requires vexR.

    Directory of Open Access Journals (Sweden)

    Dawn L Taylor

    Full Text Available Vibrio cholerae encodes six resistance-nodulation-division (RND efflux systems which function in antimicrobial resistance, virulence factor production, and intestinal colonization. Among the six RND efflux systems, VexAB exhibited broad substrate specificity and played a predominant role in intrinsic antimicrobial resistance. The VexAB system was encoded in an apparent three gene operon that included vexR; which encodes an uncharacterized TetR family regulator. In this work we examined the role of vexR in vexRAB expression. We found that VexR bound to the vexRAB promoter and vexR deletion resulted in decreased vexRAB expression and increased susceptibility to VexAB antimicrobial substrates. Substrate-dependent induction of vexRAB was dependent on vexR and episomal vexR expression provided a growth advantage in the presence of the VexAB substrate deoxycholate. The expression of vexRAB increased, in a vexR-dependent manner, in response to the loss of RND efflux activity. This suggested that VexAB may function to export intracellular metabolites. Support for this hypothesis was provided by data showing that vexRAB was upregulated in several metabolic mutants including tryptophan biosynthetic mutants that were predicted to accumulate indole. In addition, vexRAB was found to be upregulated in response to exogenous indole and to contribute to indole resistance. The collective results indicate that vexR is required for vexRAB expression in response to VexAB substrates and that the VexAB RND efflux system modulates the intracellular levels of metabolites that could otherwise accumulate to toxic levels.

  16. Substrate-dependent activation of the Vibrio cholerae vexAB RND efflux system requires vexR.

    Science.gov (United States)

    Taylor, Dawn L; Ante, Vanessa M; Bina, X Renee; Howard, Mondraya F; Bina, James E

    2015-01-01

    Vibrio cholerae encodes six resistance-nodulation-division (RND) efflux systems which function in antimicrobial resistance, virulence factor production, and intestinal colonization. Among the six RND efflux systems, VexAB exhibited broad substrate specificity and played a predominant role in intrinsic antimicrobial resistance. The VexAB system was encoded in an apparent three gene operon that included vexR; which encodes an uncharacterized TetR family regulator. In this work we examined the role of vexR in vexRAB expression. We found that VexR bound to the vexRAB promoter and vexR deletion resulted in decreased vexRAB expression and increased susceptibility to VexAB antimicrobial substrates. Substrate-dependent induction of vexRAB was dependent on vexR and episomal vexR expression provided a growth advantage in the presence of the VexAB substrate deoxycholate. The expression of vexRAB increased, in a vexR-dependent manner, in response to the loss of RND efflux activity. This suggested that VexAB may function to export intracellular metabolites. Support for this hypothesis was provided by data showing that vexRAB was upregulated in several metabolic mutants including tryptophan biosynthetic mutants that were predicted to accumulate indole. In addition, vexRAB was found to be upregulated in response to exogenous indole and to contribute to indole resistance. The collective results indicate that vexR is required for vexRAB expression in response to VexAB substrates and that the VexAB RND efflux system modulates the intracellular levels of metabolites that could otherwise accumulate to toxic levels. PMID:25695834

  17. Electronic Origins of the Variable Efficiency of Room-Temperature Methane Activation by Homo- and Heteronuclear Cluster Oxide Cations [XYO2](+) (X, Y = Al, Si, Mg): Competition between Proton-Coupled Electron Transfer and Hydrogen-Atom Transfer.

    Science.gov (United States)

    Li, Jilai; Zhou, Shaodong; Zhang, Jun; Schlangen, Maria; Weiske, Thomas; Usharani, Dandamudi; Shaik, Sason; Schwarz, Helmut

    2016-06-29

    The reactivity of the homo- and heteronuclear oxide clusters [XYO2](+) (X, Y = Al, Si, Mg) toward methane was studied using Fourier transform ion cyclotron resonance mass spectrometry, in conjunction with high-level quantum mechanical calculations. The most reactive cluster by both experiment and theory is [Al2O2](•+). In its favorable pathway, this cluster abstracts a hydrogen atom by means of proton-coupled electron transfer (PCET) instead of following the conventional hydrogen-atom transfer (HAT) route. This mechanistic choice originates in the strong Lewis acidity of the aluminum site of [Al2O2](•+), which cleaves the C-H bond heterolytically to form an Al-CH3 entity, while the proton is transferred to the bridging oxygen atom of the cluster ion. In addition, a comparison of the reactivity of heteronuclear and homonuclear oxide clusters [XYO2](+) (X, Y = Al, Si, Mg) reveals a striking doping effect by aluminum. Thus, the vacant s-p hybrid orbital on Al acts as an acceptor of the electron pair from methyl anion (CH3(-)) and is therefore eminently important for bringing about thermal methane activation by PCET. For the Al-doped cluster ions, the spin density at an oxygen atom, which is crucial for the HAT mechanism, acts here as a spectator during the course of the PCET mediated C-H bond cleavage. A diagnostic plot of the deformation energy vis-à-vis the barrier shows the different HAT/PCET reactivity map for the entire series. This is a strong connection to the recently discussed mechanism of oxidative coupling of methane on magnesium oxide surfaces proceeding through Grignard-type intermediates.

  18. "Erlösung ist, wenn man schulfrei hat!". Erste Ergebnisse einer qualitativ-empirischen Studie zur Erfassung und didaktischen Bearbeitung von Erlösungsvorstellungen 10- bis 14-jähriger SchülerInnen der Sekundarstufe I in Österreich.

    Directory of Open Access Journals (Sweden)

    Thomas Weiß

    2014-07-01

    Full Text Available ENGLISH: The teaching of redemption of mankind through God in Jesus Christ is fundamental to the Christian religion. This article expands on this central topic and presents the first results of a research carried out in schools as part of a current qualitative study about what ideas of redemption ten- to fourteen-year-old students have. The aim of this basic empirical research is to generate views and perspectives on ‚redemption‘ in children and adolescents. A further objective is to develop and integrate didactic tasks for Religious Education as a subject, in order to work on the topic of ‚redemption‘. By doing so, theological reflection should be applied and an alignment within the spheres of life of young people should be provided in lessons at School. DEUTSCH: Die Rede von der Erlösung des Menschen durch Gott in Jesus Christus ist für die christliche Religion fundamental. Der Beitrag widmet sich diesem zentralen Thema und präsentiert die ersten Forschungsergebnisse, die im Rahmen einer aktuellen qualitativen Studie zu Erlösungsvorstellungen von 10- bis 14-jährigen SchülerInnen in Schulen erhoben wurde. Diese grundlagenorientierte empirische Forschungsarbeit hat zum Ziel, kindliche / jugendliche Denk- und Sichtweisen zu ‚Erlösung’ zu generieren und didaktische Aufgaben im Religionsunterricht zu entwickeln und zu implementieren, um das Thema ‚Erlösung’ lebensweltlich orientiert und theologisch reflektiert im schulischen Unterricht bearbeiten zu können.

  19. A tőkeerő és az alapítói háttér hatása a kockázatitőke-szervezetek befektetési magatartására II.

    OpenAIRE

    Ludányi, Arnold

    2001-01-01

    A kétrészes tanulmány a kockázatitőke-ágazat befektetőszervezeteinek egyes csoportjait hasonlítja össze. Empirikus módszerrel vizsgálja az alapítói háttér és a tőkeerő feltételezett hatásait a magyar kockázatitőke-szervezetek magatartási jellemzőinek alakulására. Az alább következő második rész a kockázatitőke-szervezetekről szóló kutatás eredményeit az első részben ismertetett elemzési keret szerint foglalja össze, górcső alá véve a döntési folyamat jellemzőit, a befektetési portfólió kezelé...

  20. MM5模式在高性能系统FreeBSD上的移植及其与RHAS 4的性能比较%Transplantation of MM5 on FreeBSD and Comparison with Red Hat Advanced Server 4 on Linux

    Institute of Scientific and Technical Information of China (English)

    刘澈; 俞斌翔; 闫淑莲

    2007-01-01

    MM5模式系统常被用在气象科研和天气预报当中,通常运行在商业版本的Unix/Linux系统上,对非商业版本的类Unix系统并不太友好.文章详细介绍了MM5V3.7在高性能免费Unix操作系统FreeBSD 6.0上的移植及其应注意的问题,并通过一个个例分别在FreeBSD 6.0和Red Hat Advanced Server 4(RHAS 4)上的运行来比较其效率.通过对比发现,FreeBSD的性能要比通常所用的Linux系统有较大的提高,这对于改善实际业务中的时间迫切性问题有很大的意义.

  1. 同题异构异彩纷呈--音乐活动《墨西哥帽子舞》例析%The Same Title Heterogeneous and Splendor--Music Events"Mexican Hat Dance"Case Analysis

    Institute of Scientific and Technical Information of China (English)

    缪雯晓; 张青

    2014-01-01

    Different teachers have different understanding and grasp of the same subject matter, by comparing the three age classes of different activities designed to feel the teachers of the same subject matter, be different teaching goals, structure, and design of the different interpretations of the teaching process, thus expanding teacher's ideas and perspectives.%不同老师对同一题材内容会有不同的理解和把握,通过对比三个同龄班的不同活动设计,感受老师们对同一题材,进行不同教学目标、教学结构、教学过程的不同诠释和设计,从而拓展老师的思路和视角。

  2. Dynamical Behaviors of Multiple Equilibria in Competitive Neural Networks With Discontinuous Nonmonotonic Piecewise Linear Activation Functions.

    Science.gov (United States)

    Nie, Xiaobing; Zheng, Wei Xing

    2016-03-01

    This paper addresses the problem of coexistence and dynamical behaviors of multiple equilibria for competitive neural networks. First, a general class of discontinuous nonmonotonic piecewise linear activation functions is introduced for competitive neural networks. Then based on the fixed point theorem and theory of strict diagonal dominance matrix, it is shown that under some conditions, such n -neuron competitive neural networks can have 5(n) equilibria, among which 3(n) equilibria are locally stable and the others are unstable. More importantly, it is revealed that the neural networks with the discontinuous activation functions introduced in this paper can have both more total equilibria and locally stable equilibria than the ones with other activation functions, such as the continuous Mexican-hat-type activation function and discontinuous two-level activation function. Furthermore, the 3(n) locally stable equilibria given in this paper are located in not only saturated regions, but also unsaturated regions, which is different from the existing results on multistability of neural networks with multiple level activation functions. A simulation example is provided to illustrate and validate the theoretical findings.

  3. A szélsőséges időjárási jelenségek hatásai (Effects of the Extreme Weather Events

    Directory of Open Access Journals (Sweden)

    Tamás Molnár

    2015-04-01

    Full Text Available Economist Sir Nicholas Stern warned that the global warming could cause major blow to the world economy than the two world wars and the crisis in the 1930s. But where are we in this process now and what can be expected in the near future and what opportunities we are to curb the negative effects and to slow down the global warming. The world’s population is more than 7 billion people now and we will live more than 9 billion on the planet in 2050 according to the conservative estimation because daily the number of inhabitants increases by approximitaly a quarter of a million people (National Rural Strategy, 2020. The water and ecosystem resources are diminishing due to overuse and the values of ecological footprint are very high especially in the developed countries. The increase of extreme weather events and its effects associated with the global warming have also growing impact on agricultural production. This phenomenon is important because to solve the famine and the water shortage will be much bigger problem due to climate change than today. The VAHAVA reports (change-impact-response draw also attention to the issue which is also important for experts of climate change: Is it clearly climate change and if so than what the role of the human activity in it is? It seems clear that the assumption is almost poetic as the earth sends clear messages: the concentration of greenhouse gases increased suddenly in the atmosphere (carbon-dioxide, methan, nitrous oxide, etc, the average temperature continues to rise (increasing number of hot records, the sea temperature is also rising, the area of glaciers is shrinking dramatically and prolonged drought and flood waters in some places appear. The habitats of plans and animals, routes of bird migration change. The negative effects of extreme weather events thus represent a broad problem area. The effects can be devide into several groups. Some of them have impact already relatively short-term (for

  4. Computer Security: Join the CERN WhiteHat Challenge!

    CERN Multimedia

    Computer Security Team

    2014-01-01

    Over the past couple of months, several CERN users have reported vulnerabilities they have found in computing services and servers running at CERN. All were relevant, many were interesting and a few even surprising. Spotting weaknesses and areas for improvement before malicious people can exploit them is paramount. It helps protect the operation of our accelerators and experiments as well as the reputation of the Organization. Therefore, we would like to express our gratitude to those people for having reported these weaknesses! Great job and well done!   Seizing the opportunity, we would like to reopen the hunt for bugs, vulnerabilities and insecure configurations of CERN applications, websites and devices. You might recall we ran a similar initiative (“Hide & Seek”) in 2012 where we asked you to sift through CERN’s webpages and send us those that hold sensitive and confidential information. Quite a number of juicy documents were found and subsequently remov...

  5. Orta hat asimetrileri ve tedavi seçenekleri

    OpenAIRE

    Serpil Çokakoğlu; Ruhi Nalçacı

    2012-01-01

    Nowadays the importance given to facial aesthetic is increasing. The coincidence of facial, maxiller and mandibuler dental midlines is very important requiring facial aesthetic. Midline asymmetries can be seen in form of  dental, skeletal and/or soft tissue asymmetries. In most of cases midline asymmetries accompany with facial asymmetries. Even if the amount of patients with midline asymmetry is not known to be aware of their problems, dental midline dev...

  6. Orta hat asimetrileri ve tedavi seçenekleri

    OpenAIRE

    Çokakoğlu, Serpil; Nalçacı, Ruhi

    2013-01-01

    Nowadays the importance given to facial aesthetic is increasing. The coincidence of facial, maxiller and mandibuler dental midlines is very important requiring facial aesthetic. Midline asymmetries can be seen in form of  dental, skeletal and/or soft tissue asymmetries. In most of cases midline asymmetries accompany with facial asymmetries. Even if the amount of patients with midline asymmetry is not known to be aware of their problems, dental midline deviations observing without facial defor...

  7. hat Does the Rise in RMB Interest Rates Signify?

    Institute of Scientific and Technical Information of China (English)

    SUIJIANXIONG; LIWUZHOU

    2005-01-01

    ON October 28, 2004,the People's Bank ofChina took a U-turn and, after almost a decade of reductions, announced a 0.27 percent increase in RMB interest rates. This superficially inconsequential rise caused quite a stir on the international market. Mining stock plummeted,as did the prices of metals and crude oil futures. This reflexive investor response is just one indication that the Chinese economy has become a major driving force for global economic growth. Its huge demand has sustained high prices for oil and other staple commodities on the international market, international speculators itch to pour their hot money into China, and overseas investors too see it as a potential Klondike.

  8. Hat der ökologische Landbau in Europa eine Zukunft?

    OpenAIRE

    Offermann, Frank; Nieberg, Hiltrud

    2002-01-01

    Organic farming in Europe has increased rapidly since the early 1990s but still only accounts for a small share of production. This article analyses the structure and financial performance of organic farming in Europe using data from 18 countries. In the countries analysed, organic farms achieved significant price preniia for their outputs and were able to compete financially with conventional farms, with equal or higher profits in most cases, even though yields were up to 40 per cent lower. ...

  9. Welches Geschlecht hat die Avantgarde? Which gender has the Avantgarde?

    Directory of Open Access Journals (Sweden)

    Gertrud Lehnert

    2000-07-01

    Full Text Available Das Buch betrachtet das Theater der französischen und amerikanischen ‚Avantgarde‘ der Moderne und Postmoderne unter dem Aspekt des Geschlechts: Welcher Verfahren bedient sich avantgardistische Kunst, ist avantgardistische Kunst in geschlechtlicher Hinsicht restriktiv, oder ermöglicht sie die subversive feministische oder auch lesbisch-schwule Ausformung spezifischer Formen?In this book the French and American avantgarde theatre of the modern and postmodern period is analysed from aspects of gender. The questions raised are which processes serve to develop avantgarde art, whether avantgarde art is restrictive with regard to gender, or whether it enables a subversive feminist or specific lesbian/gay forms of theatre?

  10. A top hat for Moser's four mathemagical rabbits

    CERN Document Server

    Moree, Pieter

    2010-01-01

    If the equation 1^k+2^k+...+(m-2)^k+(m-1)^k=m^k has an integer solution with k>1, then m>10^{10^6}. Leo Moser showed this in 1953 by remarkably elementary methods. His proof rests on four identities he derives separately. It is shown here that Moser's result can be derived from a von Staudt-Clausen type theorem (an easy proof of which is also presented here). In this approach the four identities can be derived uniformly. The mathematical arguments used in the proofs were already available during the lifetime of Lagrange (1736-1813).

  11. Welche Konsequenzen hat Chinas wachsender Einfluss auf die Weltwirtschaft?

    OpenAIRE

    Hermann Remsperger; Markus Taube; Berend Diekmann; Carsten Hermann-Pillath; Rüdiger Ahrend

    2007-01-01

    In den letzten Jahren sind der ökonomische Einfluss und die Bedeutung Chinas enorm gestiegen. Hermann Remsperger, Deutsche Bundesbank, sieht in der stärkeren Integration Chinas in die Weltwirtschaft einen Gewinn, da der globale Wettbewerb zunimmt und dadurch die Produktivität weltweit gefördert wird. Allerdings sei das Land auch ein Mitverursacher von stark gewachsenen Ungleichgewichten. Berend Diekmann, Bundesministerium für Wirtschaft und Technologie, bewertet die Entwicklung ebenfalls posi...

  12. Welche Bedeutung hat der Logos in der Lateinamerikanischen Philosophie?

    OpenAIRE

    Freiler, Andreas

    2005-01-01

    In diesem Essay möchte ich die Beweggründe und Ansichten einiger lateinamerikanischer Philosophen über den Logos im lateinamerikanischen Verständnis behandeln. Im 20. Jahrhundert kam die Frage auf, ob sich eine lateinamerikanische Philosophie charakterisieren lässt. Die Befreiungsphilosophie in den sechziger und siebziger Jahren spielt in dieser Frage eine besondere Rolle. Die lateinamerikanischen Philosophen Leopoldo Zea, Enrique Dussel, Francisco Miro Quesada, Andres Roig und Alberto Villeg...

  13. Census taking in the hat: FRW/CFT duality

    International Nuclear Information System (INIS)

    In this paper a holographic description of eternal inflation is developed. We focus on the description of an open Friedmann-Robertson-Walker (FRW) universe that results from a tunneling event in which a false vacuum with positive vacuum energy decays to a supersymmetric vacuum with vanishing cosmological constant. The observations of a 'census taker' in the final vacuum can be organized into a holographic dual conformal field theory that lives on the asymptotic boundary of space. We refer to this bulk-boundary correspondence as FRW/CFT duality. The dual conformal field theory (CFT) is a Euclidean two-dimensional theory that includes a Liouville 2D gravity sector describing geometric fluctuations of the boundary. The renormalization-group flow of the theory is richer than in the AdS/CFT correspondence, and generates two space-time dimensions--one spacelike and one timelike. We discuss a number of phenomena such as bubble collisions, and the Garriga, Guth Vilenkin 'persistence of memory', from the dual viewpoint.

  14. Lack of dependence on p53 for DNA double strand break repair of episomal vectors in human lymphoblasts

    Science.gov (United States)

    Kohli, M.; Jorgensen, T. J.

    1999-01-01

    The p53 tumor suppressor gene has been shown to be involved in a variety of repair processes, and recent findings have suggested that p53 may be involved in DNA double strand break repair in irradiated cells. The role of p53 in DNA double strand break repair, however, has not been fully investigated. In this study, we have constructed a novel Epstein-Barr virus (EBV)-based shuttle vector, designated as pZEBNA, to explore the influence of p53 on DNA strand break repair in human lymphoblasts, since EBV-based vectors do not inactivate the p53 pathway. We have compared plasmid survival of irradiated, restriction enzyme linearized, and calf intestinal alkaline phosphatase (CIP)-treated pZEBNA with a Simian virus 40 (SV40)-based shuttle vector, pZ189, in TK6 (wild-type p53) and WTK1 (mutant p53) lymphoblasts and determined that p53 does not modulate DNA double strand break repair in these cell lines. Copyright 1999 Academic Press.

  15. Expresión episomal de toxina de pertussis genéticamente inactivada en Bordetella pertussis

    Directory of Open Access Journals (Sweden)

    Ernesto Marcos

    2010-01-01

    Full Text Available Bordetella pertussis es una bacteria Gram negativa, la cual constituye el agente etiologico de la tos ferina. La enfermedad se desencadena por el efecto conjunto de una serie de factores de virulencia expresados por la bacteria, los cuales se encuentran regulados por el sistema bvg. Uno de los factores de virulencia mas importantes es la toxina de pertussis, razon por la cual, se emplea de forma inactivada como el componente principal de las vacunas acelulares contra la enfermedad. La toxina de pertussis posee una estructura del tipo A-B compuesta por seis polipeptidos codificados en un operon unico. El polipeptido S1 constituye la subunidad enzimaticamente activa, la cual cataliza la transferencia de ADP-ribosa del NAD a la subunidad ALPHA de las proteinas G en celulas eucariotas, lo cual genera una serie de efectos biologicos dentro de los que se incluye: sensibilizacion a histamina, incremento de la secrecion de insulina y efectos inmunoestimuladores e inmunosupresores. El presente trabajo describe los procedimientos realizados para la obtencion de cepas de Bordetella pertussis productoras de elevadas concentraciones de toxina pertusica atenuada geneticamente. Para esto, se realizaron las sustituciones aminoacidicas Arg9 por Lys y Glu129 por Gly de la subunidad S1. El operon de la toxina de pertussis mutada se clono en un vector de amplio rango de hospedero bajo la regulacion de un promotor de expresion temprana (fhaB. Los clones obtenidos pudieran ser empleados como sistemas de expresion para produccion de vacunas acelulares en Cuba.

  16. Close sequence identity between ribosomal DNA episomes of the non-pathogenic Entamoeba dispar and pathogenic Entamoeba histolytica

    Indian Academy of Sciences (India)

    Jaishree Paul; Alok Bhattacharya; Sudha Bhattacharya

    2002-11-01

    Entamoeba dispar and Entamoeba histolytica are now recognized as two distinct species – the former being nonpathogenic to humans. We had earlier studied the organization of ribosomal RNA genes in E. histolytica. Here we report the analysis of ribosomal RNA genes in E. dispar. The rRNA genes of E. dispar, like their counterpart in E. histolytica are located on a circular rDNA molecule. From restriction map analysis, the size of E. dispar rDNA circle was estimated to be 24.4 kb. The size was also confirmed by linearizing the circle with BsaHI, and by limited DNAseI digestion. The restriction map of the E. dispar rDNA circle showed close similarity to EhR1, the rDNA circle of E. histolytica strain HM-1:IMSS which has two rDNA units per circle. The various families of short tandem repeats found in the upstream and downstream intergenic spacers (IGS) of EhR1 were also present in E. dispar. Partial sequencing of the cloned fragments of E. dispar rDNA and comparison with EhR1 revealed only 2.6% to 3.8% sequence divergence in the IGS. The region Tr and the adjoining PvuI repeats in the IGS of EhR1, which are missing in those E. histolytica strains that have one rDNA unit per circle, were present in the E. dispar rDNA circle. Such close similarity in the overall organization and sequence of the IGS of rDNAs of two different species is uncommon. In fact the spacer sequences were only slightly more divergent than the 18S rRNA gene sequence which differs by 1.6% in the two species. The most divergent sequence between E. histolytica and E. dispar was the internal transcribed spacer, ITS2. Therefore, it was concluded that probes derived from the ITS1 and ITS2 sequences would be more reliable and reproducible than probes from the IGS regions used earlier for identifying these species.

  17. Genetic Modification of Cancer Cells Using Non-Viral, Episomal S/MAR Vectors for In Vivo Tumour Modelling

    OpenAIRE

    Orestis Argyros; Suet Ping Wong; Kate Gowers; Richard Paul Harbottle

    2012-01-01

    The development of genetically marked animal tumour xenografts is an area of ongoing research to enable easier and more reliable testing of cancer therapies. Genetically marked tumour models have a number of advantages over conventional tumour models, including the easy longitudinal monitoring of therapies and the reduced number of animals needed for trials. Several different methods have been used in previous studies to mark tumours genetically, however all have limitations, such as genotoxi...

  18. Generation and reactivity of putative support systems, Ce-Al neutral binary oxide nanoclusters: CO oxidation and C–H bond activation

    International Nuclear Information System (INIS)

    Both ceria (CeO2) and alumina (Al2O3) are very important catalyst support materials. Neutral binary oxide nanoclusters (NBONCs), CexAlyOz, are generated and detected in the gas phase and their reactivity with carbon monoxide (CO) and butane (C4H10) is studied. The very active species CeAlO4• can react with CO and butane via O atom transfer (OAT) and H atom transfer (HAT), respectively. Other CexAlyOz NBONCs do not show reactivities toward CO and C4H10. The structures, as well as the reactivities, of CexAlyOz NBONCs are studied theoretically employing density functional theory (DFT) calculations. The ground state CeAlO4• NBONC possesses a kite-shaped structure with an OtCeObObAlOt configuration (Ot, terminal oxygen; Ob, bridging oxygen). An unpaired electron is localized on the Ot atom of the AlOt moiety rather than the CeOt moiety: this Ot centered radical moiety plays a very important role for the reactivity of the CeAlO4• NBONC. The reactivities of Ce2O4, CeAlO4•, and Al2O4 toward CO are compared, emphasizing the importance of a spin-localized terminal oxygen for these reactions. Intramolecular charge distributions do not appear to play a role in the reactivities of these neutral clusters, but could be important for charged isoelectronic BONCs. DFT studies show that the reaction of CeAlO4• with C4H10 to form the CeAlO4H•C4H9• encounter complex is barrierless. While HAT processes have been previously characterized for cationic and anionic oxide clusters, the reported study is the first observation of a HAT process supported by a ground state neutral oxide cluster. Mechanisms for catalytic oxidation of CO over surfaces of AlxOy/MmOn or MmOn/AlxOy materials are proposed consistent with the presented experimental and theoretical results

  19. Physical activity

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/001941.htm Physical activity To use the sharing features on this page, please enable JavaScript. Physical activity -- which includes an active lifestyle and routine exercise -- ...

  20. Human papillomaviruses activate and recruit SMC1 cohesin proteins for the differentiation-dependent life cycle through association with CTCF insulators.

    Directory of Open Access Journals (Sweden)

    Kavi Mehta

    2015-04-01

    Full Text Available Human papillomaviruses infect stratified epithelia and link their productive life cycle to the differentiation state of the host cell. Productive viral replication or amplification is restricted to highly differentiated suprabasal cells and is dependent on the activation of the ATM DNA damage pathway. The ATM pathway has three arms that can act independently of one another. One arm is centered on p53, another on CHK2 and a third on SMC1/NBS1 proteins. A role for CHK2 in HPV genome amplification has been demonstrated but it was unclear what other factors provided important activities. The cohesin protein, SMC1, is necessary for sister chromatid association prior to mitosis. In addition the phosphorylated form of SMC1 plays a critical role together with NBS1 in the ATM DNA damage response. In normal cells, SMC1 becomes phosphorylated in response to radiation, however, in HPV positive cells our studies demonstrate that it is constitutively activated. Furthermore, pSMC1 is found localized in distinct nuclear foci in complexes with γ-H2AX, and CHK2 and bound to HPV DNA. Importantly, knockdown of SMC1 blocks differentiation-dependent genome amplification. pSMC1 forms complexes with the insulator transcription factor CTCF and our studies show that these factors bind to conserved sequence motifs in the L2 late region of HPV 31. Similar motifs are found in most HPV types. Knockdown of CTCF with shRNAs blocks genome amplification and mutation of the CTCF binding motifs in the L2 open reading frame inhibits stable maintenance of viral episomes in undifferentiated cells as well as amplification of genomes upon differentiation. These findings suggest a model in which SMC1 factors are constitutively activated in HPV positive cells and recruited to viral genomes through complex formation with CTCF to facilitate genome amplification. Our findings identify both SMC1 and CTCF as critical regulators of the differentiation-dependent life cycle of high-risk human

  1. Activation detector

    Energy Technology Data Exchange (ETDEWEB)

    Bell, Zane William [Oak Ridge, TN; Boatner, Lynn Allen [Oak Ridge, TN

    2009-12-08

    A method of detecting an activator, the method including impinging with an activator a receptor material lacking a photoluminescent material and generating a by-product of a radioactive decay due to the activator impinging the reeptor material. The method further including, generating light from the by-product via the Cherenkov effect and identifying a characteristic of the activator based on the light.

  2. Active turbulence in active nematics

    Science.gov (United States)

    Thampi, S. P.; Yeomans, J. M.

    2016-07-01

    Dense, active systems show active turbulence, a state characterised by flow fields that are chaotic, with continually changing velocity jets and swirls. Here we review our current understanding of active turbulence. The development is primarily based on the theory and simulations of active liquid crystals, but with accompanying summaries of related literature.

  3. Thermal activation of building construction: possibility also in building reconstructions; Thermische Bauteilaktivierung auch bei Bauwerksanierungen

    Energy Technology Data Exchange (ETDEWEB)

    Glueck, B. [TGA Joessnitz (Plauen) (Germany)

    2002-04-01

    The thermal activation of concrete ceilings, also concrete called core activation, is getting a large spread in the last years. Since the water tubing registers must be brought in during the concreting process, this technology is not applicable in the case of reconstructions. To be able to use the energetic advantages - which occur with the use of water temperatures near room temperature, also within the construction area, there is a set of suggestions. A version, which includes even the storage in the available concrete ceilings, is examined in consideration of is efficiency. (orig.) [German] Die thermische Bauteilaktivierung von Massivdecken - auch Betonkernaktivierung genannt - hat in den letzten Jahren eine grosse Verbreitung erfahren. Da die wasserdurchflossenen Rohrregister waehrend des Betoniervorgangs eingebracht werden muessen, ist diese Technologie im Sanierungsfall nicht anwendbar. Um die energetischen Vorteile - die beim Einsatz von raumnahen Wassertemperaturen auftreten - auch im Sanierungsbereich nutzbar zu machen, gibt es eine Reihe von Vorschlaegen. Eine Variante, die sogar die Speicherung von vorhandenen Massivdecken einbezieht, wird auf ihre Leistungsfaehigkeit untersucht. (orig.)

  4. Characteristics of Relocated Quiet Zones Using Virtual Microphone Algorithm in an Active Headrest System

    Directory of Open Access Journals (Sweden)

    Seokhoon Ryu

    2016-01-01

    Full Text Available This study displays theoretical and experimental investigation on the characteristics of the relocated zone of quiet by a virtual microphone (VM based filtered-x LMS (FxLMS algorithm which can be embedded in a real-time digital controller for an active headrest system. The attenuation changes at the relocated zones of quiet by the variation of the distance between the ear and the error microphone are mainly examined. An active headrest system was implemented for the control experiment at a chair and consists of two (left and right secondary loudspeakers, two error microphones, two observer microphones at ear positions in a HATS, and other electronics including a dSPACE 1401 controller. The VM based FxLMS algorithm achieved an attenuation of about 22 dB in the control experiment against a narrowband primary noise by the variation of the distance between the ear and the error microphone. The important factors for the algorithm are discussed as well.

  5. Get Active

    Science.gov (United States)

    ... feeling the benefits of getting active, such as sleeping better or getting toned. Here are 2 ways to add more activity to your life. Be active for longer each time. If you are walking 3 days a week for 30 minutes, try ...

  6. Activation analysis

    International Nuclear Information System (INIS)

    The neutron activation analysis, which appears to be in limits for further advance, is the most suitable for providing information on the principal as well as the microcomponents in any sample of solid form. Then, instrumental activation analysis is capable of determination of far many elements in various samples. Principally on the neutron activation analysis, the following are described in literature survey from 1982 to middle 1984: bibliography, review, data collection, etc.; problems in spectral analysis and measurement; activation analysis with neutrons; charged particle and photo-nucleus reactions; chemical separation, isotopic dilution activation analysis; molecular activation analysis; standard materials; life and its relation samples; environmental, food, court trial and archaeological samples; space and earth sciences. (Mori, K.)

  7. Active ratchets

    Science.gov (United States)

    Angelani, L.; Costanzo, A.; Di Leonardo, R.

    2011-12-01

    We analyze self-propelling organisms, or active particles, in a periodic asymmetric potential. Unlike standard ratchet effect for Brownian particles requiring external forcing, in the case of active particles asymmetric potential alone produces a net drift speed (active ratchet effect). By using theoretical models and numerical simulations we demonstrate the emergence of the rectification process in the presence of an asymmetric piecewise periodic potential. The broken spatial symmetry (external potential) and time symmetry (active particles) are sufficient ingredients to sustain unidirectional transport. Our findings open the way to new mechanisms to move in directional manner motile organisms by using external periodic static fields.

  8. Physical Activity

    DEFF Research Database (Denmark)

    Andersen, Lars Bo; Anderssen, Sigmund Alfred; Wisløff, Ulrik;

    2014-01-01

    Andersen LB, Anderssen SA, Wisløff U, Hellénius M-L, Fogelholm M, Ekelund U. (Expert Group) Nordic Nutrition Recommendations 2012. Integrating nutrition and physical activity. Chapter: Physical Activity p. 195-217.Nordic Counsil of Ministers.......Andersen LB, Anderssen SA, Wisløff U, Hellénius M-L, Fogelholm M, Ekelund U. (Expert Group) Nordic Nutrition Recommendations 2012. Integrating nutrition and physical activity. Chapter: Physical Activity p. 195-217.Nordic Counsil of Ministers....

  9. Activity report

    International Nuclear Information System (INIS)

    The Department of Physics and Measurement Technology, Biology and Chemistry (IFM) presents every year a progress report containing a brief description of activities in research and education within the department. The report is intended as an information for colleagues and institutions. The present report contains activities for the academic year July 1989 to June 1990

  10. Activated Charcoal

    Science.gov (United States)

    ... reduce intestinal gas (flatulence), lower cholesterol levels, prevent hangover, and treat bile flow problems (cholestasis) during pregnancy. ... pregnancy, according to some early research reports. Preventing hangover. Activated charcoal is included in some hangover remedies, ...

  11. Foundations of Active Control - Active Noise Reduction Helmets

    DEFF Research Database (Denmark)

    Elmkjær, Torsten Haaber Leth

    2008-01-01

    includes a number of coherence analysis that are based on diffuse sound field measurements in a reverberant chamber and measurements conducted onboard a CH-47D Chinook helicopter. From these coherence analysis it can be concluded that the CFFAC system with 10 reference sensors applied to pilot helmets...... with no obvious input and output channel definition by a finite lumped-elements multi-channel system. Usually, no unique transfer function x exist as the system is not point-wise excited, but excited over an area as in the case of diffuse sound field illumination. A new method for acoustical signal processing...... on a head and torso simulator (HATS), is exposed to diffuse sound field illumination. By applying the JCRSA method the spatially-weighted-averaged acquisition lead times provided by the reference sensors relative to the performance sensors are estimated to be as much as 800-900μs. The thesis also includes...

  12. Protease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cells.

    Directory of Open Access Journals (Sweden)

    Dennis J Grab

    Full Text Available BACKGROUND: Using human brain microvascular endothelial cells (HBMECs as an in vitro model for how African trypanosomes cross the human blood-brain barrier (BBB we recently reported that the parasites cross the BBB by generating calcium activation signals in HBMECs through the activity of parasite cysteine proteases, particularly cathepsin L (brucipain. In the current study, we examined the possible role of a class of protease stimulated HBMEC G protein coupled receptors (GPCRs known as protease activated receptors (PARs that might be implicated in calcium signaling by African trypanosomes. METHODOLOGY/PRINCIPAL FINDINGS: Using RNA interference (RNAi we found that in vitro PAR-2 gene (F2RL1 expression in HBMEC monolayers could be reduced by over 95%. We also found that the ability of Trypanosoma brucei rhodesiense to cross F2RL1-silenced HBMEC monolayers was reduced (39%-49% and that HBMECs silenced for F2RL1 maintained control levels of barrier function in the presence of the parasite. Consistent with the role of PAR-2, we found that HBMEC barrier function was also maintained after blockade of Galpha(q with Pasteurella multocida toxin (PMT. PAR-2 signaling has been shown in other systems to have neuroinflammatory and neuroprotective roles and our data implicate a role for proteases (i.e. brucipain and PAR-2 in African trypanosome/HBMEC interactions. Using gene-profiling methods to interrogate candidate HBMEC pathways specifically triggered by brucipain, several pathways that potentially link some pathophysiologic processes associated with CNS HAT were identified. CONCLUSIONS/SIGNIFICANCE: Together, the data support a role, in part, for GPCRs as molecular targets for parasite proteases that lead to the activation of Galpha(q-mediated calcium signaling. The consequence of these events is predicted to be increased permeability of the BBB to parasite transmigration and the initiation of neuroinflammation, events precursory to CNS disease.

  13. Regulatory activities

    International Nuclear Information System (INIS)

    This publication, compiled in 8 chapters, presents the regulatory system developed by the Nuclear Regulatory Authority (NRA) of the Argentine Republic. The following activities and developed topics in this document describe: the evolution of the nuclear regulatory activity in Argentina; the Argentine regulatory system; the nuclear regulatory laws and standards; the inspection and safeguards of nuclear facilities; the emergency systems; the environmental systems; the environmental monitoring; the analysis laboratories on physical and biological dosimetry, prenatal irradiation, internal irradiation, radiation measurements, detection techniques on nuclear testing, medical program on radiation protection; the institutional relations with national and international organization; the training courses and meeting; the technical information

  14. Active Power

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    ActivePower,Inc.(NASDAQ股票代号:ACPW)成立于1992年,是一家久负盛誉的不间断电源解决方案供应商。Active Power凭借其卓越的飞轮储能技术,Cleansouce UPS系统和全系列的电源解决方案,为客户提供高效,可靠且环保的电源系统,以确保在发生电源波动时实现业务连续。

  15. Active house

    DEFF Research Database (Denmark)

    Eriksen, Kurt Emil; Olesen, Gitte Gylling Hammershøj

    2010-01-01

    Formålet med dette abstrakt er at illustrere, at huse kan være konstrueret til at basere sig udelukkende på vedvarende energikilder og samtidig være CO2-neutrale og producere mere energi end de forbruger. Active House Visionen undersøger disse muligheder i otte demonstration huse i fem forskellige...

  16. Activated Sludge.

    Science.gov (United States)

    Saunders, F. Michael

    1978-01-01

    Presents the 1978 literature review of wastewater treatment. This review covers: (1) activated sludge process; (2) process control; (3) oxygen uptake and transfer; (4) phosphorus removal; (5) nitrification; (6) industrial wastewater; and (7) aerobic digestion. A list of 136 references is also presented. (HM)

  17. Transcription Factors Ets2 and Sp1 Act Synergistically with Histone Acetyltransferase p300 in Activating Human Interleukin-12 p40 Promoter

    Institute of Scientific and Technical Information of China (English)

    Hai-Jing SUN; Xin XU; Xiu-Li WANG; Liang WEI; Fen LI; Jun LU; Bai-Qu HUANG

    2006-01-01

    There has been considerable interest in researching the regulatory mechanisms that control the synthesis of interleukin (IL)-12, which plays a central role in the differentiation of T-helper-1 cells. In this study, we performed a series of transient transfection experiments designed to elucidate the functional relationship between the IL-12 promoter-specific transcription factors (Ets2 and Spl) and histone acetylation modification in IL-12 regulation mediated by p300 and various histone deacetylases (HDACs). Results presented in this report demonstrated that the transcription factors Ets2 and Spl acted synergistically with p300to activate the human IL-12 promoter. The histone acetyltransferase (HAT) activity of p300 was required for this synergic effect, because the adenovirus E1A protein inhibited the synergy. Conversely, HDACs repressed the synergic effect of transcription factors and histone acetylation on the activation of IL-12, while p300 was able to rectify it. These data indicated that Ets2 and Sp1 worked concertedly and synergistically with p300 in the regulation of human IL-12 expression.

  18. Activity report

    Energy Technology Data Exchange (ETDEWEB)

    Yu, S W

    2008-08-11

    This report is aimed to show the author's activities to support the LDRD. The title is 'Investigation of the Double-C Behavior in the Pu-Ga Time-Temperature-Transformation Diagram' The sections are: (1) Sample Holder Test; (2) Calculation of x-ray diffraction patterns; (3) Literature search and preparing publications; (4) Tasks Required for APS Experiments; and (5) Communications.

  19. Hepatoprotective Activity.

    Science.gov (United States)

    2016-01-01

    The liver performs a vital role in metabolism, secretion, storage, and detoxification of endogenous and exogenous substances. Oxidative stress and free radicals enhance the severity of hepatic damage, which can be overcome by the antioxidant mechanism. Plant extracts can be the best source of such antioxidants and mediate hepatoprotective activity. In this chapter, high-dose paracetamol-induced hepatotoxicity in rat model is discussed with explanations of biochemical and histopathological studies. PMID:26939279

  20. Glucokinase activators.

    Science.gov (United States)

    Filipski, Kevin J; Futatsugi, Kentaro; Pfefferkorn, Jeffrey A; Stevens, Benjamin D

    2012-07-01

    In this review we highlight recently disclosed progress in the field of small-molecule activators of the human glucokinase enzyme. Several of the reported chemotypes possess structural features that diverge from known leads; some of these modifications appear to be specifically designed to modulate tissue selectivity or discrete parameters of enzyme function (e.g., S0.5 v Vmax). This review will inform the reader of the extent of continued effort being directed toward discovery of a first-in-class drug for Type II diabetes mellitus that functions through this target. Patents were selected from those published in December 2009 up to November 2011; foreign filings were translated where possible to understand the claims and biological techniques utilized to characterize the reported glucokinase activators. Overall, there appears to be a recent trend leading to reduced patent filings for small-molecule glucokinase activators. There are many possible explanations for this trend; however, it is likely that the field has reached maturity and that the downturn of new disclosures represents the transition of many of these programs to the clinic.

  1. Raman and surface enhanced Raman spectroscopic studies of specific, small molecule activator of histone acetyltransferase p300

    Science.gov (United States)

    Kundu, Partha P.; Pavan Kumar, G. V.; Mantelingu, Kempegowda; Kundu, Tapas K.; Narayana, Chandrabhas

    2011-07-01

    We report for the first time, the Raman and surface enhanced Raman scattering (SERS) studies of N-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide (CTB). This molecule is specific activator of human histone acetyltransferase (HAT), p300, and serves as lead molecule to design anti-neoplastic therapeutics. A detailed Raman and SERS band assignments have been performed for CTB, which are compared with the density functional theory calculations. The observed red shift of N sbnd H stretching frequency from the computed wavenumber indicates the weakening of N sbnd H bond resulting from proton transfer to the neighboring oxygen atom. We observe Ag sbnd N vibrational mode at 234 cm -1 in SERS of CTB. This indicates there is a metal-molecule bond leading to chemical enhancement in SERS. We also observe, enhancement in the modes pertaining to substituted benzene rings and methyl groups. Based on SERS analysis we propose the adsorption sites and the orientation of CTB on silver surface.

  2. Activating schoolyards

    DEFF Research Database (Denmark)

    Andersen, Henriette Bondo; Pawlowski, Charlotte Skau; Scheller, Hanne Bebendorf;

    2015-01-01

    objectively determine where and how active the students are in the schoolyard, before and after the intervention. This provides a type of data that, to our knowledge, has not been used before in schoolyard interventions. Exploring the change in behavior in relation to specific intervention elements in the...... accelerometer, GPS and GIS; 3) a process evaluation facilitating the intervention development process and identifying barriers and facilitators in the implementation process; 4) a post-intervention end-user evaluation aimed at exploring who uses the schoolyards and how the schoolyards are used. The seven...

  3. Active packaging with antifungal activities.

    Science.gov (United States)

    Nguyen Van Long, N; Joly, Catherine; Dantigny, Philippe

    2016-03-01

    There have been many reviews concerned with antimicrobial food packaging, and with the use of antifungal compounds, but none provided an exhaustive picture of the applications of active packaging to control fungal spoilage. Very recently, many studies have been done in these fields, therefore it is timely to review this topic. This article examines the effects of essential oils, preservatives, natural products, chemical fungicides, nanoparticles coated to different films, and chitosan in vitro on the growth of moulds, but also in vivo on the mould free shelf-life of bread, cheese, and fresh fruits and vegetables. A short section is also dedicated to yeasts. All the applications are described from a microbiological point of view, and these were sorted depending on the name of the species. Methods and results obtained are discussed. Essential oils and preservatives were ranked by increased efficacy on mould growth. For all the tested molecules, Penicillium species were shown more sensitive than Aspergillus species. However, comparison between the results was difficult because it appeared that the efficiency of active packaging depended greatly on the environmental factors of food such as water activity, pH, temperature, NaCl concentration, the nature, the size, and the mode of application of the films, in addition to the fact that the amount of released antifungal compounds was not constant with time.

  4. Active packaging with antifungal activities.

    Science.gov (United States)

    Nguyen Van Long, N; Joly, Catherine; Dantigny, Philippe

    2016-03-01

    There have been many reviews concerned with antimicrobial food packaging, and with the use of antifungal compounds, but none provided an exhaustive picture of the applications of active packaging to control fungal spoilage. Very recently, many studies have been done in these fields, therefore it is timely to review this topic. This article examines the effects of essential oils, preservatives, natural products, chemical fungicides, nanoparticles coated to different films, and chitosan in vitro on the growth of moulds, but also in vivo on the mould free shelf-life of bread, cheese, and fresh fruits and vegetables. A short section is also dedicated to yeasts. All the applications are described from a microbiological point of view, and these were sorted depending on the name of the species. Methods and results obtained are discussed. Essential oils and preservatives were ranked by increased efficacy on mould growth. For all the tested molecules, Penicillium species were shown more sensitive than Aspergillus species. However, comparison between the results was difficult because it appeared that the efficiency of active packaging depended greatly on the environmental factors of food such as water activity, pH, temperature, NaCl concentration, the nature, the size, and the mode of application of the films, in addition to the fact that the amount of released antifungal compounds was not constant with time. PMID:26803804

  5. Halal Activism

    DEFF Research Database (Denmark)

    Fischer, Johan

    2016-01-01

    The purpose of this article is to further our understanding of contemporary Muslim consumer activism in Malaysia with a particular focus on halal (in Arabic, literally “permissible” or “lawful”) products and services. Muslim activists and organisations promote halal on a big scale in the interface...... zones between new forms of Islamic revivalism, the ethnicised state and Muslim consumer culture. Organisations such as the Muslim Consumers Association of Malaysia play an important role in pushing and protecting halal in Malaysia, that is, halal activists constantly call on the state to tighten halal...... in particular historical/national settings and that these issues should be explored in the interfaces between Islam, the state and market. More specifically, this article examines the above issues building on ethnography from fieldwork with three Muslim organisations in Malaysia....

  6. PM6 study of free radical scavenging mechanisms of flavonoids: why does O-H bond dissociation enthalpy effectively represent free radical scavenging activity?

    Science.gov (United States)

    Amić, Dragan; Stepanić, Višnja; Lučić, Bono; Marković, Zoran; Dimitrić Marković, Jasmina M

    2013-06-01

    It is well known that the bond dissociation enthalpy (BDE) of the O-H group is related to the hydrogen atom transfer (HAT) mechanism of free radical scavenging that is preferred in gas-phase and non-polar solvents. The present work shows that the BDE may also be related to radical scavenging processes taking place in polar solvents, i.e., single electron transfer followed by proton transfer (SET-PT) and sequential proton loss electron transfer (SPLET). This is so because the total energy requirements related to the SET-PT [sum of the ionization potential (IP) and proton dissociation enthalpy (PDE)] and the SPLET [sum of the proton affinity (PA) and electron transfer enthalpy (ETE)] are perfectly correlated with the BDE. This could explain why the published data for polyphenolic antioxidant activity measured by various assays are better correlated with the BDE than with other reaction enthalpies involved in radical scavenging mechanisms, i.e., the IP, PDE, PA and ETE. The BDE is fairly well able to rank flavonoids as antioxidants in any medium, but to conclude which radical scavenging mechanism represents the most probable reaction pathway from the thermodynamic point of view, the IP and PA (ETE) should also be considered. This is exemplified in the case of the radical scavenging activity of 25 flavonoids.

  7. Thanatos-associated protein 7 associates with template activating factor-Ibeta and inhibits histone acetylation to repress transcription.

    Science.gov (United States)

    Macfarlan, Todd; Parker, J Brandon; Nagata, Kyosuke; Chakravarti, Debabrata

    2006-02-01

    The posttranslational modifications of histones on chromatin or a lack thereof is critical in transcriptional regulation. Emerging studies indicate a role for histone-binding proteins in transcriptional activation and repression. We have previously identified template-activating factor-Ibeta (TAF-Ibeta, also called PHAPII, SET, and I(2)(pp2A)) as a component of a cellular complex called inhibitor of acetyltransferases (INHAT) that masks histone acetylation in vitro and blocks histone acetyltransferase (HAT)-dependent transcription in living cells. TAF-Ibeta has also been shown to associate with transcription factors, including nuclear receptors, to regulate their activities. To identify novel interactors of TAF-Ibeta, we employed a yeast two-hybrid screen and identified a previously uncharacterized human protein called thanatos-associated protein-7 (THAP7), a member of a large family of THAP domain-containing putative DNA-binding proteins. In this study we demonstrate that THAP7 associates with TAF-Ibeta in vitro and map their association domains to a C-terminal predicted coiled-coil motif on THAP7 and the central region of TAF-Ibeta. Similarly, stably transfected THAP7 associates with endogenous TAF-Ibeta in intact cells. Like TAF-Ibeta, THAP7 associates with histone H3 and histone H4 and inhibits histone acetylation. The histone-interacting domain of THAP7 is sufficient for this activity in vitro. Promoter-targeted THAP7 can also recruit TAF-Ibeta and silencing mediator of retinoid and thyroid receptors/nuclear hormone receptor corepressor (NCoR) proteins to promoters, and knockdown of TAF-Ibeta by small interfering RNA relieves THAP7-mediated repression, indicating that, like nuclear hormone receptors, THAP7 may represent a novel class of transcription factor that uses TAF-Ibeta as a corepressor to maintain histones in a hypoacetylated, repressed state. PMID:16195249

  8. Active sharing

    CERN Multimedia

    2012-01-01

    The big news this week is, of course, the conclusions from the LHC performance workshop held in Chamonix from 6 to 10 February . The main recommendation, endorsed by CERN’s Machine Advisory Committee and adopted by the Management, is that the LHC will run at 4 TeV per beam this year. You can find all the details from Chamonix in the slides presented on Wednesday at the summary session, which leaves me free to talk about another important development coming up soon.   In ten days time, a new kind of gathering will be taking place in Geneva, bringing together two previously separate conferences, one driven by physics, the other by the medical community, but both looking to apply physics to the advancement of health. The merger of the International Conference for Translational Research in Radio-Oncology and CERN’s workshop on Physics for Health in Europe (ICTR-PHE) makes for a very eclectic mix. Presentations range from active shielding for interplanetary flight to the rather...

  9. DAVIC activities

    Science.gov (United States)

    Fujiwara, Hiroshi

    1995-12-01

    DAVIC (Digital Audio Visual Council) is the defacto standardization organization established in Mar. 1994, based on international consensus for digital audio visual services. After completion of MPEG2 standardization, the broadcasting industry, the communication industry, the computer industry, and consumer electronics industry have started development of concrete services and products. Especially the interactive digital audio visual services, such as Video On Demand (VOD) or Near Video On Demand (NVOD), have become hot topics all over the world. Such interactive digital audio visual services are combined technologies of multi-media coding, digital transmission and computer networking. Therefore more than 150 organizations from all industry sectors have participated in DAVIC and are contributing from their own industrial contexts. DAVIC's basic policy is to use the available technologies specified by the other standards bodies as much as possible. So DAVIC's standardization activities have close relationship with ISO IEC/JTC1/SC29, ITU-T SG 9, ATM-Forum, IETF, IMA, DVB, etc. DAVIC is trying to specify Applications, Reference Models, Security, Usage Information Control, and the interfaces and protocols among the Content Provider, the Server, the core network, the access network, and the Set Top Unit. DAVIC's first goal is to specify DAVIC1.0 based on CFP1 (Call for Proposal) and CFP2 by Dec. 1995, and the next direction is under preparation for further progress based on CFP3 and CFP4.

  10. Effects of Supercritical Carbon Dioxide and Sub-critical Propane Extraction of Thyme and Cardamom on Chemical Composition, Antioxidant Capacity and Antimicrobial Properties (Kakukkfű és kardámom szuperkritikus széndioxid és szubkritikus propán extrakciójának hatása az oleoresin kémiai össztételére, antioxidáns kapacitására és antimikrobás tulajdonságára)

    OpenAIRE

    Hamdan, Samer A. N.

    2008-01-01

    Munkám során a szuperkritikus CO2 és szubkritikus propán extrakciónak a kakukkfűből, illetve kardamom magból készült oleoresin összetételére, antioxidáns kapacitására és antimikrobás aktivitására gyakorolt hatását tűztem ki célul. Az extrakciót a Veszprémi Egyetemhez tartozó félüzemi berendezéssel végeztem. A szuperkritikus CO2 extrakciót 80 és 400 baron, 35-55 °C-on, a szuperkritikus propán extrakciót pedig 25-50 baron, 25 °C-on végeztem. Kontrolként a két gyógynövényből kivonatot készítette...

  11. IASS Activity

    Science.gov (United States)

    Hojaev, Alisher S.; Ibragimova, Elvira M.

    2015-08-01

    It’s well known, astronomy in Uzbekistan has ancient roots and traditions (e.g., Mirzo Ulugh Beg, Abū al-Rayhān al-Bīrūnī, Abū ‘Abdallāh al-Khwārizmī) and astronomical heritage carefully preserved. Nowadays uzbek astronomers play a key role in scientific research but also in OAD and Decadal Plan activity in the Central Asia region. International Aerospace School (IASS) is an amazing and wonderful event held annually about 30 years. IASS is unique project in the region, and at the beginning we spent the Summer and Winter Schools. At present in the summer camp we gather about 50 teenage and undergraduate students over the country and abroad (France, Malaysia, Turkey, Azerbaijan, Pakistan, Russia, etc.). They are selected on the basis of tests of astronomy and space issues. During two weeks of IASS camp the invited scientists, cosmonauts and astronauts as well as other specialists give lectures and engage in practical exercises with IASS students in astronomy, including daily observations of the Sun and night sky observations with meniscus telescope, space research and exploration, aerospace modelling, preparation and presentation of original projects. This is important that IASS gives not theoretical grounds only but also practically train the students and the hands-on training is the major aims of IASS. Lectures and practice in the field of astronomy carried out with the direct involvement and generous assistance of Uranoscope Association (Paris, France). The current 26-th IASS is planned to held in July 2015.

  12. Physical Activity (Exercise)

    Science.gov (United States)

    ... Our ePublications > Physical activity (exercise) fact sheet ePublications Physical activity (exercise) fact sheet How can physical activity improve ... Have had recent hip surgery More information on physical activity (exercise) For more information about physical activity (exercise), ...

  13. MAR介导的非病毒附着体载体的研究进展%Research Progress of the Matrix Attachment Mediated Nonvirus Episomal Vector

    Institute of Scientific and Technical Information of China (English)

    林艳; 李照熙; 王芳; 王天云

    2012-01-01

    附着体载体可以使外源基因在宿主细胞中不整合到基因组上而是以附着体的形式存在,是一种新型的高效、安全、附着体表达载体.目前研究较多的是由S/MAR(Scaffold/Matrix Attachment Region,S/MAR)元件介导的质粒.虽然此类载体均能介导载体附着存在,但是转基因的表达量不同.最近研究发现,载体的启动子、骨架结构、CpG基序以及表达系统等方面能够影响转基因的表达,针对以上内容作一综述,希望据此进一步优化载体,为临床研究提供基础依据.

  14. Identification of episomal human papillomavirus and other DNA viruses in cytological anal samples of HIV-uninfected men who have sex with men.

    Directory of Open Access Journals (Sweden)

    Maria Gabriella Donà

    Full Text Available To date, there have been only few studies that investigated integration of anal Human Papillomavirus (HPV. Most of them were conducted on HIV-infected individuals and mainly analyzed samples from high-grade lesions and invasive cancer. We aimed to investigate HPV physical status in HIV-negative men who have sex with men (MSM with a detectable anal HPV infection, irrespective of the presence of lesions. We also sought to explore the presence of other circular DNA viruses in the anal region. Study participants were attendees of an STI screening program, which were also screened for anal HPV infection and cytological abnormalities. HPV physical status was assessed using multiply-primed RCA. HPV16-positive samples were also analyzed using E2/E6 multiplex PCR, qRT-PCR and APOT assay. RCA and virus-specific PCR were employed to investigate the presence of other DNA viruses. Anal HPV infection was detected in 76.9% of the 230 MSM enrolled. The anal cytological reports were: 129 NILM, 37 ASC-US and 28 L-SIL (36 samples were inadequate for interpretation. HPV physical status was evaluated in the 109 anal specimens that harbored one or two different HPV genotypes. Integration was observed only in one HPV16-positive sample (0.9%, in which integrate-derived viral transcripts of type B were detected. Integration occurred in chromosome 14 q. In 22 of the 53 (41.5% mucosal HPV-negative samples, RCA restriction results would seem to indicate the presence of circular DNA viruses. Indeed, cutaneous HPV (4 samples, MCPyV (5 samples and TTV (4 samples were detected. In conclusion, anal HPV integration was rarely evidenced in HIV-uninfected MSM with no or mild anal cytological abnormalities, although the integration rate may have been underestimated because of the limitations of the employed assays. Other DNA viruses were detected in the anal samples of these individuals, although the significance of this occurrence needs to be assessed.

  15. The histone acetyltransferase domains of CREB-binding protein (CBP) and p300/CBP-associated factor are not necessary for cooperativity with the class II transactivator.

    Science.gov (United States)

    Harton, J A; Zika, E; Ting, J P

    2001-10-19

    The class II transactivator (CIITA) is a transcriptional co-activator regulating the constitutive and interferon-gamma-inducible expression of class II major histocompatibility complex (MHC) and related genes. Promoter remodeling occurs following CIITA induction, suggesting the involvement of chromatin remodeling factors. Transcription of numerous genes requires the histone acetyltransferase (HAT) activities of CREB-binding protein (CBP), p300, and/or p300/CBP-associated factor (pCAF). These co-activators cooperate with CIITA and are hypothesized to promote class II major histocompatibility complex transcription through their HAT activity. To directly test this, we used HAT-defective CBP and pCAF. We demonstrate that cooperation between CIITA and CBP is independent of CBP HAT activity. Further, although pCAF enhances CIITA-mediated transcription, pCAF HAT domain dependence appears contingent upon the concentration of available CIITA. When HAT-defective CBP and pCAF are both present, cooperativity with CIITA is maintained. Consistent with a recent report, we show that nuclear localization of CIITA is enhanced by lysine 144, an in vitro target of pCAF-mediated HAT. Yet we find that neither mutation of lysine 144 nor deletion of residues 132-209 affects transcriptional cooperation with CBP or pCAF. Thus, acetylation of this residue may not be the primary mechanism for pCAF/CBP cooperation with CIITA. In conclusion, the HAT activities of the co-activators are not necessary for cooperation with CIITA.

  16. The role of partnerships in promoting physical activity: the experience of Agita São Paulo.

    Science.gov (United States)

    Matsudo, Victor

    2012-01-01

    Strategic partnership is a logical approach to face some of the public health problems. However, its application is somewhat more complex. In this paper our experience with three networks (Agita São Paulo, Physical Activity Network of Americas, and Agita Mundo Network) was described. In the case of Agita São Paulo even the name was a consequence of a partnership with a marketing company, and is an idiomatic expression that means much more than just to move your body. It also means to move psychologically and socially, with the concept of "active citizenship". Among the important features of that intervention, we highlighted: (a) national and international intellectual partnership; (b) strong institutional partnerships, including government in one hand, and non-governmental and private sector in the other hand, in a so called: "two-hats approach"; (c) minimal formalization/maximal flexibility; (d) a signed letter of agreement: an active symbol of institutional commitment; (e) use the "mobile management" adaptation of the ecological model, in which attention was given to intrapersonal, social, and physical environmental factors, in a dynamic way; (f) attention to inter-sectoral as well as to intra-sectoral partners, in which creates incentives for participation of more than one representative from each sector; (g) the inclusion principle, that was not restricted to the institution, but affected the program actions, materials, and particularly the messages; (h) a high level of legitimacy of the coordination institution in the leadership; (i) special attention to improve environment supports for physical activity, such as: strategic partnerships established with the Metro System, that serves over 1 million persons/day; the Truck Drivers Radio Station; the State Secretariat of Environment, that built a walking path around its main building; the city of São Caetano do Sul, with the healthy sidewalk program; the city of Santana do Parnaiba building a walking path

  17. An exploratory study on the peroxyl-radical-scavenging activity of 2,6-dimethyl-5-hepten-2-ol and its heterocyclic analogues

    Science.gov (United States)

    Stobiecka, Agnieszka; Sikora, Magdalena; Bonikowski, Radosław; Kula, Józef

    2016-03-01

    The structural properties and radical scavenging activity of 2,6-dimethyl-5-hepten-2-ol (1) and its new heterocyclic analogues, i.e. 2-methyl-4-(5-methylfuran-2-yl)-butan-2-ol (2) and 2-methyl-4-(5-methylthiophen-2-yl)-butan-2-ol (3) and have been studied by using the experimental and theoretical methods for the first time. Activity of title compounds against the peroxyl radical was determined by using standard fluorimetric test, i.e. the Oxygen Radical Absorbance Capacity assay (ORACFL). Furthermore, the electron-donating ability of odorants has been evaluated by using colorimetric ABTS assay. According to the experimental results obtained from the ORACFL test 2,6-dimethyl-5-hepten-2-ol was characterized by the highest activity in comparison with the novel counterparts. Nevertheless, all investigated compounds exhibited pronounced anti-peroxyl radical activity comparable to that exerted by the one of the most prominent antioxidant among the monoterpene alcohols, i.e. by linalool. On the other hand, the title compounds exerted relatively low capacity to quench the radical cation of ABTS. Theoretical calculations based on the Density Functional Theory (DFT) method with the hybrid functional B3LYP were carried out in order to investigate selected structural and electronic properties including the geometrical parameters as well as the energy of frontier molecular orbitals of parent molecules and the resulting radicals. Furthermore, the possible mechanism of peroxyl-radical-scavenging has been determined by using the thermodynamic descriptors such as the bond dissociation enthalpies (BDEs) and ionization potentials (IPs). These theoretical data pointed out the relevance of HAT mechanism in the peroxyl-radical-scavenging exhibited by 2,6-dimethyl-5-hepten-2-ol and its new heterocyclic analogues in polar and non-polar medium.

  18. Charitable activities in Azerbaijan

    OpenAIRE

    Ismailova Sevil Aydin

    2015-01-01

    In this article, found its proper reflection questions related to the issue of charitable activities in Azerbaijan. Briefly described the history of charitable activities in Azerbaijan. Also shown is the legal framework of charitable activities in Azerbaijan.

  19. Guide to Physical Activity

    Science.gov (United States)

    ... Families ( We Can! ) Health Professional Resources Guide to Physical Activity Physical activity is an important part of your ... to injury. Examples of moderate-intensity amounts of physical activity Common Chores Washing and waxing a car for ...

  20. Physical Activity Assessment

    Science.gov (United States)

    Current evidence convincingly indicates that physical activity reduces the risk of colon and breast cancer. Physical activity may also reduce risk of prostate cancer. Scientists are also evaluating potential relationships between physical activity and other cancers.

  1. Modulations of hMOF autoacetylation by SIRT1 regulate hMOF recruitment and activities on the chromatin

    Institute of Scientific and Technical Information of China (English)

    Lu Lu; Lei Li; Xiang Lv; Xue-Song Wu; De-Pei Liu; Chih-Chuan Liang

    2011-01-01

    A wide variety of nuclear regulators and enzymes are subjected to acetylation of the lysine residue, which regulates different aspects of protein functions. The MYST family histone acetyltransferase, human ortholog of MOF (hMOF), plays critical roles in transcription activation by acetylating nucleosomai H4K16. In this study, we found that hMOF acetylates itself in vitro and in vivo, and the acetylation is restricted to the conserved MYST domain (C2HC zinc finger and HAT), of which the K274 residue is the major autoacetylation site. Furthermore, the class Ⅲ histone deacetylase SIRT1 was found to interact with the MYST domain of hMOF through the deacetylase catalytic region and deacetylate autoacetylated hMOF. In vitro binding assays showed that non-acetylated hMOF robustly binds to nucleosomes while acetylation decreases the binding ability. In HeLa cells, the recruitment of hMOF to the chromatin increases in response to SIRT1 overexpression and decreases after knockdown of SIRT1. The acetylation mimic mutation K274Q apparently decreases the chromatin recruitment of hMOF as well as the global H4K16Ac level in HeLa cells. Finally, upon SIRT1 knockdown, hMOF recruitment to the gene body region of its target gene HoxA9 decreases, accompanied with decrease of H4K16Ac at the same region and repression of HoxA9 transcription. These results suggest a dynamic interplay between SIRT1 and hMOF in regulating H4K16 acetylation.

  2. Political activity for physical activity: health advocacy for active transport

    Directory of Open Access Journals (Sweden)

    Amun Qa-t-a

    2011-05-01

    Full Text Available Abstract Effective health advocacy is a priority for efforts to increase population participation in physical activity. Local councils are an important audience for this advocacy. The aim of the current study was to describe features of advocacy for active transport via submissions to city council annual plans in New Zealand, and the impact of an information sheet to encourage the health sector to be involved in this process. Written submissions to city council's annual consultation process were requested for 16 city councils over the period of three years (2007/08, 2008/09, and 2009/10. Submissions were reviewed and categories of responses were created. An advocacy information sheet encouraging health sector participation and summarising some of the evidence-base related to physical activity, active transport and health was released just prior to the 2009/10 submission time. Over the period of the study, city councils received 47,392 submissions, 17% of which were related to active transport. Most submissions came from city residents, with a small proportion (2% from the health sector. The largest category of submissions was in support of pedestrian and cycling infrastructure, design and maintenance of facilities and additional features to support use of these transport modes. Health arguments featured prominently in justifications for active transport initiatives, including concerns about injury risk, obesity, physical inactivity, personal safety and facilities for people with disabilities. There was evidence that the information sheet was utilised by some health sector submitters (12.5%, providing tentative support for initiatives of this nature. In conclusion, the study provides novel information about the current nature of health advocacy for active transport and informs future advocacy efforts about areas for emphasis, such as health benefits of active transport, and potential alliances with other sectors such as environmental

  3. Active commuting to school

    Science.gov (United States)

    Declines in physical activity levels have coincided with increasing rates of obesity in children. This is problematic because physical activity has been shown to attenuate weight gain in children. Active commuting to school is one way of increasing children's physical activity. However, given the hi...

  4. Increasing Youth Physical Activity with Activity Calendars

    Science.gov (United States)

    Eckler, Seth

    2016-01-01

    Physical educators often struggle with ways to get their students to be active beyond the school day. One strategy to accomplish this is the use of physical activity calendars (PACs). The purpose of this article is to support the use of PACs and give practical advice for creating effective PACs.

  5. Persistent active longitudes in sunspot activity

    Science.gov (United States)

    Berdyugina, S.; Usoskin, I.

    It has been recently shown that spot activity of cool stars including solar analogues, is grouped in two clearly distinguished active longitudes which are persistent within at least one starspot cycle. Solar data including positional information of individual sunspots / groups extends back for about 130 years covering 12 solar cycles. Here we present the results of our research of longitudinal distribution of sunspot activity using an analysis similar to that applied to the stars. First, we synthesized, from the actual sunspot data, the sun's light curve as if it was defined only by spots. Then solar images were calculated from this light curve, giving a natural smoothing of the spot pattern. For each Carrington rotation, longitudinal position of these smoothed spot regions was calculated. The analysis reveals the following main features: - Sunspot activity is grouped in two active longitudes (with the differential rotation taken into account) 180o apart from each other which are persistent through the entire studied period of 12 cycles, similarly to stars. - The longitude migration is determined by changing the mean latitude of sunspot activity (the Maunder butterfly) and differential rotation. - The two longitudes periodically alternate the dominant activity with about 3.7 year period implying for the existence of the Sflip-flopT phenomenon known in - starspot activity.

  6. Neutron Activation Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Corliss, William R.

    1968-01-01

    In activation analysis, a sample of an unknown material is first irradiated (activated) with nuclear particles. In practice these nuclear particles are almost always neutrons. The success of activation analysis depends upon nuclear reactions which are completely independent of an atom's chemical associations. The value of activation analysis as a research tool was recognized almost immediately upon the discovery of artificial radioactivity. This book discusses activation analysis experiments, applications and technical considerations.

  7. Flip flops, dress clothes, and no coat: clothing barriers to children's physical activity in child-care centers identified from a qualitative study

    Directory of Open Access Journals (Sweden)

    Saelens Brian E

    2009-11-01

    Full Text Available Abstract Background Three-quarters of 3-6 year-old children in the U.S. spend time in childcare; many spend most of their waking hours in these settings. Daily physical activity offers numerous health benefits, but activity levels vary widely across centers. This study was undertaken to explore reasons why physical activity levels may vary. The purpose of this paper is to summarize an unexpected finding that child-care providers cited was a key barrier to children's physical activity. Methods Nine focus groups with 49 child-care providers (55% black from 34 centers (including inner-city, suburban, Head Start and Montessori were conducted in Cincinnati, OH. Three independent raters analyzed verbatim transcripts for themes. Several techniques were used to increase credibility of findings, including interviews with 13 caregivers. Results Two major themes about clothing were: 1 children's clothing was a barrier to children's physical activity in child-care, and 2 clothing choices were a significant source of conflict between parents and child-care providers. Inappropriate clothing items included: no coat/hat/gloves in the wintertime, flip flops or sandals, dress/expensive clothes, jewelry, and clothes that were either too loose or too tight. Child-care providers explained that unless there were enough extra coats at the center, a single child without a coat could prevent the entire class from going outside. Caregivers suggested several reasons why parents may dress their child inappropriately, including forgetfulness, a rushed morning routine, limited income to buy clothes, a child's preference for a favorite item, and parents not understanding the importance of outdoor play. Several child-care providers favored specific policies prohibiting inappropriate clothing, as many reported limited success with verbal or written reminders to bring appropriate clothing. Conclusion Inappropriate clothing may be an important barrier to children's physical

  8. Hat die Psychiatrie Aufgaben in der Diagnostik gesellschaftlicher Befindlichkeiten und Problemlagen?

    Directory of Open Access Journals (Sweden)

    Emrich HM

    2009-01-01

    Full Text Available Hinsichtlich der Frage nach gesellschaftlichen Befindlichkeiten und Problemlagen erscheint es sinnvoll, die verschiedenen soziologischen Reflexionsebenen zu unterscheiden: die mikrosoziale Ebene, den Mesobereich und die Makroebene der Politik. Die gesellschaftlichen Problemlagen und emotionalen Situationen werden dabei in der Gegenwart sehr stark durch die Konzepte der "postmodernen Hyperflexibilität" (Lyotard geprägt, wobei insbesondere auch die Medien eine zentrale Funktion einnehmen. Hierbei zeigt sich, dass es eine neue Form von Inszenierungen und Selbstdarstellungen gibt, die man als "Hysterie als Lebensform" charakterisieren kann.

  9. CALLIGRAPHY OF STACKED FRUIT IN ART OF CALLIGRAPHY / HAT SANATINDA MEYVE ISTIFLI HATLAR

    Directory of Open Access Journals (Sweden)

    Dr. Zübeyde Cihan ÖZSAYINER

    2008-10-01

    Full Text Available Calligraphy with stacked fruit in the art ofcalligraphy In Turkish culture fruit has created afundamental element used lovingly in architecture,calligraphy, miniatures, woodwork, metalwork, porcelain art, carpets, towels, edging, printed cloth, embroidery,folk art and gravestones. As a result of studies, it hasbeen shown that fruit has the symbolic meanings ofimmortality, the existence that is the core of something, ajewel and truth. It is seen that the symbolisms of fruit byitself changes according to societies. The apple becamethe fruit of the tree in paradise and the “golden apple” isthe symbol of immortality. The grape symbolizes autumn,the pomegranate bountifulness, reproduction, maternityand birth. As a result of my research in the art ofcalligraphy it has been proven that there are manuscriptsreflecting religious and mystic subjects have beenstacked neatly in the forms of pears, apples andpomegranate. In the Turkish Foundation CalligraphicArts Museum, the only such one in Turkey and in theworld there are three examples of calligraphy neatlystacked in pear form. It seems that the stacked fruit inthe form of pears, apples and pomegranates and writtenin various techniques were lovingly used by calligrapherswho had great creative power, sought change in theTurkish art of calligraphy and worked in religious andmystic circles.

  10. $\\Delta I=1/2$ Rule and $\\hat B_K$ : 2014

    CERN Document Server

    Buras, Andrzej J

    2014-01-01

    I summarize the status of the $\\Delta I=1/2$ rule in $K\\to\\pi\\pi$ decays within an {\\it analytic} approach based on the dual representation of QCD as a theory of weakly interacting mesons for large $N$, where $N$ is the number of colours. This approximate approach, developed in the 1980s by William Bardeen, Jean-Marc G\\'erard and myself identified already 28 years ago the dominant dynamics behind the $\\Delta I=1/2$ rule. However, the recent inclusion of lowest-lying vector meson contributions in addition to the pseudoscalar ones to hadronic matrix elements of current-current operators and the calculation of the corresponding Wilson coefficients in a momentum scheme at the NLO improved significantly the matching between quark-gluon short distance contributions and meson long distance contributions over our results in 1986. We obtain satisfactory description of the ${\\rm Re}A_2$ amplitude and ${\\rm Re}A_0/{\\rm Re}A_2=16.0\\pm 1.5$ to be compared with its experimental value of $22.3$. While this difference could ...

  11. Who has priority during the regulation?; Wer hat Vorrang beim Abregeln?

    Energy Technology Data Exchange (ETDEWEB)

    Janzing, Bernward

    2013-04-15

    The remote control of wind power plants by direct marketers raises questions - not only on the technology, but also on the hierarchy of actors. From the technical perspective, the current practice of feed-in is not particularly well developed. So far, the regulation of wind turbines via radio ripple control is carried out in stages to 60, 30 and 0 %. The traditional ripple control technology does not send a message back to the sender if the wind turbine has received the signal and reacts to it. Smart meter and digital control technology can provide assistance in this case. Consequences for the plant safety result from this regulation: The performance of a wind turbine shall be reduced only with a gradient of ten percent of the initial output per minute. If the data transfer is interrupted, the reduction of the power will be closed automatically after 30 minutes.

  12. Transparency has its price. Historical heat insulation - Windows; Transparenz hat ihren Preis. Historischer Waermeschutz - Fenster

    Energy Technology Data Exchange (ETDEWEB)

    Eicke-Hennig, Werner [Institut Wohnen und Umwelt (IWU), Darmstadt (Germany)

    2011-04-15

    Until thousand years ago, the openings for light and air in huts and houses were no more than drafty holes ('windows'). Only in the early Middle Ages, people began to close the windows in the winter with translucent animal skins and other auxiliary materials. From the 11th Century the aristocracy occassionally afforded window glasses in the form of small bull's eye panes for the first time. As from the 18th century, new inventions improved the glass quality - from then on the progress preceded stormy. After the first oil crisis, the thermal insulation and thus the first insulating glazing come into play.

  13. Toward a 21st-Century Understanding of Humans' Relation to Nature: Two Hats?

    Science.gov (United States)

    Rennie, Scott

    2008-01-01

    From its inception, environmental education (EE) has shouldered the imposition of impartiality on its methods and practices. Considering the reality of global climate change, the author urges the adoption of the more accurate theory of humans' relation to the natural world. This theory necessitates partiality toward healthy, functioning natural…

  14. The effect of hat on phototherapy-induced hypocalcemia in jaundiced full-term neonates

    OpenAIRE

    Ezzeldin Z; Mansi Y; Abdelhamid TA; Sabry M

    2015-01-01

    Zahraa Ezzeldin, Yasmeen Mansi, Tamer A Abdelhamid, Mohamed Sabry Department of Pediatrics, Faculty of Medicine, Cairo University, Giza, Egypt Background: It has been hypothesized that phototherapy leads to increased calcium absorption by the bones through irradiating the pineal gland and reducing melatonin level. There is some evidence that the use of a stockinet cap to cover the head prevents phototherapy-induced hypocalcemia. Study design: This was a randomized controlled trial, including...

  15. Six thinking hats for electricity markets simulation: adapting meeting tools to agent decision

    OpenAIRE

    Barreto, João Costa Borges

    2012-01-01

    In almost all industrialized countries, the energy sector has suffered a severe restructuring that originated a greater complexity in market players’ interactions. The complexity that these changes brought made way for the creation of decision support tools that facilitate the study and understanding of these markets. MASCEM – “Multiagent Simulator for Competitive Electricity Markets” arose in this context providing a framework for evaluating new rules, new behaviour, and new participants ...

  16. Zur klinischen Bedeutung von Geschwistererfahrungen - hat die Geschwistererfahrung einen Einfluss auf seelische Erkrankungen?

    OpenAIRE

    Adam-Lauterbach, Dorothee

    2012-01-01

    Im Mittelpunkt der Arbeit steht die Frage, ob bei psychogenen Störungen Geschwistererfahrungen klinische Relevanz haben und ob die erfahrene Geschwisterposition und –konstellation auch im Erwachsenenalter psychodynamisch wirksam ist. Die Arbeit gliedert sich in drei Teile. Im ersten Teil werden in einem metatheoretischen Vorgehen psychoanalytische Konzepte, psychoanalytische Entwicklungstheorien aus der Objekt- und Selbstpsychologie und empirische Forschungsergebnisse zur Geschwisterbezie...

  17. "Tied together like a woven hat:" Protective pathways to Alaska native sobriety

    Directory of Open Access Journals (Sweden)

    Mohatt Gerald V

    2004-11-01

    Full Text Available Abstract Background The People Awakening Project (1RO1 AA 11446-03 had two purposes, completed in Phase I and Phase II of the project. The purpose of Phase I was to complete a qualitative study; the research objective was discovery oriented with the specific aim of identification of protective and recovery factors in Alaska Native sobriety. Results were used to develop a heuristic model of protective and recovery factors, and measures based on these factors. The research objective of Phase II was to pilot these measures and provide initial validity data. Methods Phase I utilized a life history methodology. People Awakening interviewed a convenience sample of 101 Alaska Natives who had either recovered from alcoholism (n = 58 or never had a drinking problem (n = 43. This later group included both lifetime abstainers (LAs and non-problem drinkers (NPs. Life histories were transcribed and analyzed using grounded theory and consensual data analytic procedures within a participatory action research framework. Analyses were utilized to generate heuristic models of protection and recovery from alcohol abuse among Alaska Natives. Results Analyses generated a heuristic model of protective factors from alcohol abuse. The resulting multilevel and multi-factorial model describes interactive and reciprocal influences of (a individual, family, and community characteristics; (b trauma and the individual and contextual response to trauma, (c experimental substance use and the person's social environment; and (d reflective processes associated with a turning point, or a life decision regarding sobriety. The importance of cultural factors mediating all these protective processes is emphasized. For NPs, the resilience process drew from personal stores of self-confidence, self-efficacy, and self-mastery that derived from ability to successfully maneuver within stressful or potentially traumatizing environments. In contrast, for many LAs, efficacy was instead described in more socially embedded terms better understood as communal mastery. One style of mastery is more associated with individualistic orientations, the other with more collectivistic. Future research is needed regarding the generalizeability of this group difference. Conclusions Results suggest that preventative interventions should focus on intervening simultaneously at the community, family, and individual levels to build resilience and protective factors at each level. Of particular importance is the building of reflexivity along with other cognitive processes that allow the individual to think through problems and to reach a life decision to not abuse alcohol.

  18. The G-HAT Infrared Search for Extraterrestrial Civilizations with Large Energy Supplies

    Science.gov (United States)

    Wright, Jason Thomas; Povich, Matthew; Griffith, Roger; Maldonado, Jessica; Sigurdsson, Steinn; Star Cartier, Kimberly

    2015-08-01

    The WISE and Spitzer large-area surveys of the mid-infrared sky bring a new opportunity to search for evidence of the energy supplies of very large extraterrestrial civilizations. If these energy supplies rival the output of a civilization's parent star (Kardashev Type II), or if a galaxy-spanning supercivilization's use rivals that of the total galactic luminosity (Type III), they would be detectable as anomolously mid-infrared-bright stars and galaxies, respectively. We have already performed the first search for this emission from Type III civilizations using the WISE all-sky survey, and put the first upper limits on them in the local universe, and discuss ways to improve on these limits. We also discuss some detectable forms of and limits on Type II civilizations in the Mliky Way.

  19. [Trabecular hyalinizing adenoma of the thyroid (HAT): A report of two cases].

    Science.gov (United States)

    Román-González, Alejandro; Simón-Duque, Carlos; Camilo-Pérez, Juan; Vélez-Hoyo, Alejandro

    2016-01-01

    The hyalinizing trabecular adenoma is a rare lesion of the thyroid. There is controversy in the literature about the correct name for this disease. Dr. Carney defended the benign nature of this condition and therefore continues calling it adenoma, the World Health Organization calls for the potential of tumor malignancy, and others qualify it as a variant of papillary carcinoma based on the presence of rearranged in transformation/papillary thyroid carcinoma (RET/PTC) rearrangements. In Latin America there are few reported cases. Two cases of hyalinizing trabecular adenoma are reported. The first is a 40-year-old woman with a thyroid nodule of 3x3 cm. The immunohistochemistry was positive for thyroglobulin and calcitonin and negative for cytokeratin 19 and chromogranin. The second case is a 36-year-old patient with a thyroid nodule of 4x4 cm with an immunohistochemical pattern identical to the first case. Trabecular hyalinizing adenoma is a benign disease, easily confused with papillary or medullary thyroid carcinoma. Awareness of this entity will allow a better classification and management of thyroid conditions. PMID:26927651

  20. Phosphorus-based Flame Retardancy Mechanisms—Old Hat or a Starting Point for Future Development?

    Directory of Open Access Journals (Sweden)

    Bernhard Schartel

    2010-09-01

    Full Text Available Different kinds of additive and reactive flame retardants containing phosphorus are increasingly successful as halogen-free alternatives for various polymeric materials and applications. Phosphorus can act in the condensed phase by enhancing charring, yielding intumescence, or through inorganic glass formation; and in the gas phase through flame inhibition. Occurrence and efficiency depend, not only on the flame retardant itself, but also on its interaction with pyrolysing polymeric material and additives. Flame retardancy is sensitive to modification of the flame retardant, the use of synergists/adjuvants, and changes to the polymeric material. A detailed understanding facilitates the launch of tailored and targeted development.

  1. Indigenous Knowledge in the Life Sciences Classroom: Put on Your de Bono Hats!

    Science.gov (United States)

    de Beer, Josef; Whitlock, Elrina

    2009-01-01

    The whole world was united in its condemnation of the pre-1994 apartheid regime in South Africa. Apartheid meant that many South Africans were robbed of their democratic voices and cultural identities. In this article, the authors pose the question: Are you guilty of "knowledge apartheid" in your biology classroom? Does every student have a voice…

  2. The rabbit in the hat: dubious argumentation and the persuasive effects of prescription drug advertising (DTCA).

    Science.gov (United States)

    Rubinelli, Sara; Nakamoto, Kent; Schulz, Peter J

    2008-01-01

    There is an ongoing global debate over the potential benefits and risks of allowing direct-to-consumer advertising of prescription medicines (DTCA). The core of this debate concerns the identification of DTCA either as a beneficial procedure to be promoted or as a damaging procedure to be abolished. Economic data on DTCA suggest that this form of advertising has an impact on consumers. Based on this premise, we explore the use of argumentation theory to inquire into the reasons for this success. In particular, by combining perspectives from argumentation theory and marketing research this paper aims to test the hypothesis of whether DTCA presents information framed in potentially misleading, but persuasive, argumentative structures. We highlight and discuss the results of two studies designed to assess whether readers perceive DTCA as argumentative and, if so, which explicit and implicit elements provide groundings for the inference that consumers draw from the ads. The analysis highlights the presence in DTCA of dubious arguments (fallacies and distracting claims) that may go unnoticed. Also, it illustrates the nature of readers' wrong assumptions that arise independently from the contents of the ads. These factors seem to influence the level of the self-perceived persuasiveness of DTCA. PMID:19363879

  3. The Epidemiology of Childhood Asthma in Red Deer and Medicine Hat, Alberta

    Directory of Open Access Journals (Sweden)

    Patrick A Hessel

    2001-01-01

    Full Text Available OBJECTIVES: To document the prevalence of asthma among school-aged children in two Alberta communities, to understand host and indoor environmental factors associated with asthma, and to compare these factors between the two communities.

  4. Brand Communities and Well-being: Learning to Age in a Red Hat

    OpenAIRE

    Moscato, Emily Marie

    2014-01-01

    The older female segment plays a critical role in society's fabric, as women past retirement volunteer a significant amount in their communities and provide essential caregiving to family members and friends. Moreover, older females outnumber older males and with the baby boomer population aging over 65, this segment is becoming more influential. Yet there is surprisingly little marketing research that focuses on this older female segment, their lived experiences, and their well-being. Workin...

  5. Pharmacogenetic effects of 'candidate gene complexes' on stroke in the GenHAT study

    DEFF Research Database (Denmark)

    Sørensen, Izel F; Vazquez, Ana I; Irvin, Marguerite R;

    2014-01-01

    OBJECTIVE: The aim of this study was to investigate whether there is a genotype-by-treatment interaction in patients experiencing stroke and treated with one of three antihypertensive drugs, that is chlorthalidone, amlodipine, or lisinopril. PARTICIPANTS AND METHODS: A population of 436 African...

  6. The rabbit in the hat: dubious argumentation and the persuasive effects of prescription drug advertising (DTCA).

    Science.gov (United States)

    Rubinelli, Sara; Nakamoto, Kent; Schulz, Peter J

    2008-01-01

    There is an ongoing global debate over the potential benefits and risks of allowing direct-to-consumer advertising of prescription medicines (DTCA). The core of this debate concerns the identification of DTCA either as a beneficial procedure to be promoted or as a damaging procedure to be abolished. Economic data on DTCA suggest that this form of advertising has an impact on consumers. Based on this premise, we explore the use of argumentation theory to inquire into the reasons for this success. In particular, by combining perspectives from argumentation theory and marketing research this paper aims to test the hypothesis of whether DTCA presents information framed in potentially misleading, but persuasive, argumentative structures. We highlight and discuss the results of two studies designed to assess whether readers perceive DTCA as argumentative and, if so, which explicit and implicit elements provide groundings for the inference that consumers draw from the ads. The analysis highlights the presence in DTCA of dubious arguments (fallacies and distracting claims) that may go unnoticed. Also, it illustrates the nature of readers' wrong assumptions that arise independently from the contents of the ads. These factors seem to influence the level of the self-perceived persuasiveness of DTCA.

  7. "Good Guys Don't Wear Hats": Children's Talk about the Media.

    Science.gov (United States)

    Tobin, Joseph

    This book details an ethnographic study focused on how children think and talk about media representations of violence, gender, race, colonialism, and social class. Participating in the study were 162 elementary school students in Hawaii. Groups of 6- to 12-year-olds viewed clips from 2 television commercials and 2 movies and were later…

  8. CETA: Welche Effekte hat das EU-Kanada-Freihandelsabkommen auf Deutschland?

    OpenAIRE

    Rahel Aichele; Gabriel Felbermayr

    2014-01-01

    Das CETA-Abkommen sieht die Abschaffung von Zöllen, regulatorische Zusammenarbeit und Investitionsschutz zwischen der EU und Kanada vor. Nach unseren Simulationsrechnungen könnte es langfristig die Exporte Deutschlands nach Kanada verdreifachen und die Importe verdoppeln. CETA könnte in Deutschland einen langfristigen Zuwachs des realen Pro-Kopf-Einkommens von 0,2% ermöglichen; Kanada würde jedoch deutlich stärker profitieren. Der größte Nutznießer in Deutschland wäre der Fahrzeugbau; der Ber...

  9. Red Hat Fedora Linux 2 All-in-One Desk Reference For Dummies

    CERN Document Server

    Barkakati, Naba

    2004-01-01

    This essential reference organizes material into a set of nine stand-alone, task-oriented minibooks that enable readers to understand all aspects of the Fedora OS, the latest release of the most popular Linux distributionEach minibook covers a different aspect of Fedora, such as getting users started with Fedora, the various workstations and applications, OpenOffice.org, networking, system administration, security, running Internet servers on a Fedora system, and programmingMore experienced readers can use this desktop reference to look up how to perform specific tasks, such as hooking up to t

  10. Wearing More than One Hat: Improving Student-Authored Case Longevity while Encouraging Additional Student Roles

    Science.gov (United States)

    Corrigan, Hope; Craciun, Georgiana

    2012-01-01

    The marketing education literature emphasizes and documents the effectiveness of using the student-authored case (SAC) method as a means to develop managerial and critical thinking skills. However, most SACs are short lived, lack suggested case solutions, do not benefit from peer feedback, and present challenges in finding relevant company data.…

  11. "...dass man einen festen Glauben daran hat, dass das jetzige System die Rettung sei"

    DEFF Research Database (Denmark)

    Lammers, Karl Christian

    2011-01-01

    Undersøgelse af den danske gesandt i Berlin Herluf Zahles beretning om og vurdering af forholdet mellem Hitler og tyskerne.......Undersøgelse af den danske gesandt i Berlin Herluf Zahles beretning om og vurdering af forholdet mellem Hitler og tyskerne....

  12. The Sorting Hat Effect: How the Hogwarts Houses Influence Prejudice in Harry Potter

    OpenAIRE

    Helga Sædís Jónsdóttir 1994

    2016-01-01

    This essay explores the various prejudices shown in the Harry Potter book series by J.K. Rowling. Hogwarts is the only wizarding school in Great Britain and as every witch or wizard in Great Britain passes through the doors of the school, the school has an enormous influence on the magical community. At Hogwarts rivalry between the four houses is encouraged and the students are conditioned to look down on the students of the other houses and anything they associate with each house. Outside of...

  13. Nuclear power has a future; Kernenergie hat Zukunft. Eroeffnungsrede zur Wintertagung des Deutschen Atomforums in Berlin

    Energy Technology Data Exchange (ETDEWEB)

    Majewski, O. [Bayernwerk AG, Muenchen (Germany)

    2000-03-01

    Consensus is possible. This is the message of the President of the Deutsches Atomforum, Dr. Otto Majewski, at the opening of the Forum's Winter Meeting in Berlin. Majewski emphasized that the operators of nuclear power plants urgently needed security in planning, given the rapid change in the European electricity market. It was time to get away from the onesided discussion about running times and opt-out, and focus again on the entire spectrum of a long term, calculable, reliable energy policy. Besides a sustainable clarification of the transport issue, the retroactive taxation of the reserves accumulated for waste management constituted an unacceptable burden on operators. Companies would take legal action against these measures, should it turn out to be necessary. Dr. Majewski expressed himself unequivocally in favour of the EPR as a reactor line for the future. (orig.) [German] 'Ein Konsens ist moeglich. Aber anstatt an starren Laufzeiten zu kleben, gilt es einen intelligenten Loesungsansatz zu finden', so Dr. Otto Majewski, Praesident des Deutschen Atomforums zur Eroeffnung der DAtF-Wintertagung in Berlin. Majewski machte deutlich, dass die deutschen Kernenergie-Betreiber vor dem Hintergrund des raschen Wandels im europaeischen Strommarkt vor allem Planungssicherheit brauchen. Die Ueberlegung, ueber Laufzeit- bzw. Strommengen-Kontingente zu verhandeln, haelt Majewski fuer einen denkbaren Ansatz. Neben der nachhaltigen Klaerung der Transportfrage sei die rueckwirkende Besteuerung der Entsorgungsrueckstellungen eine unakzeptable Belastung der Betreiber. Der DAtF-Praesident bekraeftigte die Entschlossenheit der Unternehmen, diese Bestimmungen notfalls vor Gericht zu Fall zu bringen. Gleichzeitig sparch er sich fuer den EPR als kuenftige Reaktorlinie aus. (orig.)

  14. Commodity Cluster Computing for Remote Sensing Applications using Red Hat LINUX

    Science.gov (United States)

    Dorband, John

    2003-01-01

    Since 1994, we have been doing research at Goddard Space Flight Center on implementing a wide variety of applications on commodity based computing clusters. This talk is about these clusters and haw they are used on these applications including ones for remote sensing.

  15. Frihet till hat? : Hatbrott, rasistiska organisationer och inskränkningar av yttrandefriheten

    OpenAIRE

    Peippo, Patric

    2011-01-01

    The present paper is part of a project carried on by the Swedish Section of the International Commission of Jurists. Sweden has ratified several major international human rights instruments. Most of the rights are covered by national law, and only in exception is there a discrepancy between national and international law. Such a discrepancy is found in the UN Convention on the Elimination of all forms of Racial Discrimination, in which the State parties agree on penalizing and prohibiting the...

  16. Hat sich das Gehirn beim Haushunde, im Vergleich mit Wildhundarten, vergrössert, oder verkleinert

    NARCIS (Netherlands)

    Dubois, Eug.

    1922-01-01

    In dem inhaltreichen Buche „Der Mensch. Sein Ursprung und seine Entwicklung” von W. LECHE ¹) finden sich die sehr merkwürdigen Abbildungen zweier „Skeletten von nahezu derselben Grösse, das eine von einem zahmen Hund, das andere von einer wilden Hundeart”, nach der Meinung des Autors „schlagende Bei

  17. "Die Nato hat einen grossen Fehler begangen" / Toomas Hendrik Ilves ; interv. Ansgar Graw

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2008-01-01

    Eesti president räägib sõjalistest kokkupõrgetest Gruusias, vajadusest uue rahvusvahelise julgeolekustruktuuri järele, ootustest rahvusvahelise üldsuse suhtes, Balti riikide julgeolekust ning kritiseerib NATO otsust mitte anda Gruusiale NATO liikmelisuse tegevuskava

  18. 基于Red Hat Linux9的DNS系统研究

    Institute of Scientific and Technical Information of China (English)

    高源

    2009-01-01

    DNS是域名系统(Domain Name System)的缩写,该系统用于命名组织到域层次结构中的计算机和网络服务。互联网中的DNS服务器绝大多数是基于Linux系统创建的。从Linux DNS的初级配置着手,对快速配置出简单有效的DNS服务器进行了论述。

  19. Deutsche Weine und ihre Stellung in Norwegen : hat die "Renaissance des Rieslings" Norwegen erreicht?

    OpenAIRE

    2006-01-01

    In dieser Masterarbeit wird die Geschichte des deutschen Weinanbaus erzählt und die Stellung deutscher Weine in Norwegen untersucht. In der zweiten Hälfte des 20. Jahrhunderts setzten immer mehr deutsche Winzer auf Quantität statt auf Qualität, woraufhin der deutsche Weinanbau allmählich sein gutes Ansehen verlor. Zwar waren massenhaft produzierte preiswerte, süße Weine, besonders die „Liebfraumilch“, äußerst beliebte Exportwaren, jedoch drängten sie die Prädikatsweine fast vollständig in den...

  20. Many Hats and a Delicate Balance: The Lives and Times of Today's Special Education Directors

    Science.gov (United States)

    Thompson, James R.; O'Brian, Mary

    2007-01-01

    A statewide survey of special education directors revealed that director of special education preparation programs should be time limited and offered in convenient locations to recruit the best possible pool of students and future directors. Current directors have come to their positions through numerous and diverse career paths. The lack of…