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Sample records for active disassembly balance

  1. Impact of different disassembly line balancing algorithms on the performance of dynamic kanban system for disassembly line

    Science.gov (United States)

    Kizilkaya, Elif A.; Gupta, Surendra M.

    2005-11-01

    In this paper, we compare the impact of different disassembly line balancing (DLB) algorithms on the performance of our recently introduced Dynamic Kanban System for Disassembly Line (DKSDL) to accommodate the vagaries of uncertainties associated with disassembly and remanufacturing processing. We consider a case study to illustrate the impact of various DLB algorithms on the DKSDL. The approach to the solution, scenario settings, results and the discussions of the results are included.

  2. An Entropy-Based Adaptive Hybrid Particle Swarm Optimization for Disassembly Line Balancing Problems

    Directory of Open Access Journals (Sweden)

    Shanli Xiao

    2017-11-01

    Full Text Available In order to improve the product disassembly efficiency, the disassembly line balancing problem (DLBP is transformed into a problem of searching for the optimum path in the directed and weighted graph by constructing the disassembly hierarchy information graph (DHIG. Then, combining the characteristic of the disassembly sequence, an entropy-based adaptive hybrid particle swarm optimization algorithm (AHPSO is presented. In this algorithm, entropy is introduced to measure the changing tendency of population diversity, and the dimension learning, crossover and mutation operator are used to increase the probability of producing feasible disassembly solutions (FDS. Performance of the proposed methodology is tested on the primary problem instances available in the literature, and the results are compared with other evolutionary algorithms. The results show that the proposed algorithm is efficient to solve the complex DLBP.

  3. Balancing Disassembly Line in Product Recovery to Promote the Coordinated Development of Economy and Environment

    Directory of Open Access Journals (Sweden)

    Jia Liu

    2017-02-01

    Full Text Available For environmentally conscious and sustainable manufacturing, many more manufacturers are acting to recycle and remanufacture their post-consumed products. The most critical process of remanufacturing is disassembly, since it allows for the selective extraction of the valuable components and materials from returned products to reduce the waste disposal volume. It is, therefore, important to design and balance the disassembly line to work efficiently due to its vital role in effective resource usage and environmental protection. Considering the disassembly precedence relationships and sequence-dependent parts removal time increments, this paper presents an improved discrete artificial bee colony algorithm (DABC for solving the sequence-dependent disassembly line balancing problem (SDDLBP. The performance of the proposed algorithm was tested against nine other approaches. Computational results evidently indicate the superior efficiency of the proposed algorithm for addressing the environmental and economic concerns while optimizing the multi-objective SDDLBP.

  4. Shape memory polymer nanocomposites for application of multiple-field active disassembly: experiment and simulation.

    Science.gov (United States)

    Carrell, John; Zhang, Hong-Chao; Wang, Shiren; Tate, Derrick

    2013-11-19

    Active disassembly (AD) uses innovative materials that can perform a designed disassembly action by the application of an external field. AD provides improvements over current disassembly processes by limiting machine or manual labor and enabling batch processing for end-of-life products. With improved disassembly operations, more reuse of components and purer recycling streams may be seen. One problem with AD, however, has been with the single-field actuation because of the probability of accidental disassembly. This presentation will discuss the application of shape memory polymer (SMP) nanocomposites in a new AD process. This novel AD process requires multiple-field actuation of the SMP nanocomposite fastener. In the analysis of this AD process, thermal and magnetic field tests were performed on the SMP nanocomposite. From these tests, finite-element analysis was performed to model and simulate the multiple-field AD process. The results of the simulations provide performance variables for the AD process and show a better performance time for the SMP nanocomposite fastener than for a comparable SMP fastener.

  5. Pit disassembly and conversion demonstration environmental assessment and research and development activities

    International Nuclear Information System (INIS)

    1998-08-01

    A significant portion of the surplus plutonium is in the form of pits, a nuclear weapons component. Pits are composed of plutonium which is sealed in a metallic shell. These pits would need to be safely disassembled and permanently converted to an unclassified form that would be suitable for long-term disposition and international inspection. To determine the feasibility of an integrated pit disassembly and conversion system, a Pit Disassembly and Conversion Demonstration is proposed to take place at the Los Alamos National Laboratory (LANL). This demonstration would be done in existing buildings and facilities, and would involve the disassembly of up to 250 pits and conversion of the recovered plutonium to plutonium metal ingots and plutonium dioxide. This demonstration also includes the conversion of up to 80 kilograms of clean plutonium metal to plutonium dioxide because, as part of the disposition process, some surplus plutonium metal may be converted to plutonium dioxide in the same facility as the surplus pits. The equipment to be used for the proposed demonstration addressed in this EA would use some parts of the Advanced Recovery and Integrated Extraction System (ARIES) capability, other existing equipment/capacities, plus new equipment that was developed at other sites. In addition, small-scale R and D activities are currently underway as part of the overall surplus plutonium disposition program. These R and D activities are related to pit disassembly and conversion, MOX fuel fabrication, and immobilization (in glass and ceramic forms). They are described in Section 7.0. On May 16, 1997, the Office of Fissile Materials Disposition (MD) notified potentially affected states and tribes that this EA would be prepared in accordance with NEPA. This EA has been prepared to provide sufficient information for DOE to determine whether a Finding of No Significant Impact (FONSI) is warranted or whether an EIS must be prepared

  6. Modeling operational behavior of a disassembly line

    Science.gov (United States)

    Kizilkaya, Elif A.; Gupta, Surendra M.

    2004-12-01

    In this paper we present a dynamic kanban (pull) system specifically developed for disassembly lines. This type of kanban system is much more complex than the traditional kanban system used in assembly lines. For instance, unlike the assembly line where the external demand occurs only at the last station, the demands in the disassembly case also occur at any of the intermittent stations. The reason is that as a product moves on the disassembly line, various parts are disassembled at every station and accumulated at that station. Therefore, there are as many demand sources as there are number of parts. We consider a case example involving the end-of-life products. Based on the precedence relationships and other criteria such as hazardous properties of the parts, we balance the disassembly line. The results of the disassembly line-balancing problem (DLBP) are used as input to the proposed dynamic kanban system for disassembly line (DKSDL). We compare the performance of the DKSDL to the modified kanban system for disassembly line (MKSDL), which was previously introduced by the authors. We show, via simulation, that the DKSDL is far superior to MKSDL considered.

  7. The pedagogical value of Disassemble/Analyze/Assemble (DAA) activities: Assessing the potential for motivation and transfer

    Science.gov (United States)

    Dalrymple, Odesma Onika

    Undergraduate engineering institutions are currently seeking to improve recruiting practices and to retain engineering majors particularly by addressing what many studies document as a major challenge of poor instruction. There is an undisputed need for instructional practices that motivate students in addition to facilitating the transfer of learning beyond the classroom. Reverse engineering and product dissection, more broadly termed Disassemble/Analyze/Assemble (DAA) activities, have shown potential to address these concerns, based on the reviews of students and professors alike. DAA activities involve the systematic deconstruction of an artifact, the subsequent analysis and possible reconstruction of its components for the purpose of understanding the embodied fundamental concepts, design principles and developmental processes. These activities have been part of regular industry practice for some time; however, the systematic analysis of their benefits for learning and instruction is a relatively recent phenomenon. A number of studies have provided highly descriptive accounts of curricula and possible outcomes of DAA activities; but, relatively few have compared participants doing DAA activities to a control group doing more traditional activities. In this respect, two quasi-experiments were conducted as part of a first-year engineering laboratory, and it was hypothesized that students who engaged in the DAA activity would be more motivated and would demonstrate higher frequencies of transfer than the control. A DAA activity that required students to disassemble a single-use camera and analyze its components to discover how it works was compared to a step-by-step laboratory activity in the first experiment and a lecture method of instruction in the second experiment. In both experiments, over forty percent of the students that engaged in the DAA activity demonstrated the ability to transfer the knowledge gained about the functions of the camera's components and

  8. T1R3 homomeric sweet taste receptor regulates adipogenesis through Gαs-mediated microtubules disassembly and Rho activation in 3T3-L1 cells.

    Directory of Open Access Journals (Sweden)

    Yosuke Masubuchi

    Full Text Available We previously reported that 3T3-L1 cells express a functional sweet taste receptor possibly as a T1R3 homomer that is coupled to Gs and negatively regulates adipogenesis by a Gαs-mediated but cAMP-independent mechanism. Here, we show that stimulation of this receptor with sucralose or saccharin induced disassembly of the microtubules in 3T3-L1 preadipocytes, which was attenuated by overexpression of the dominant-negative mutant of Gαs (Gαs-G226A. In contrast, overexpression of the constitutively active mutant of Gαs (Gαs-Q227L as well as treatment with cholera toxin or isoproterenol but not with forskolin caused disassembly of the microtubules. Sweetener-induced microtubule disassembly was accompanied by activation of RhoA and Rho-associated kinase (ROCK. This was attenuated with by knockdown of GEF-H1, a microtubule-localized guanine nucleotide exchange factor for Rho GTPase. Furthermore, overexpression of the dominant-negative mutant of RhoA (RhoA-T19N blocked sweetener-induced dephosphorylation of Akt and repression of PPARγ and C/EBPα in the early phase of adipogenic differentiation. These results suggest that the T1R3 homomeric sweet taste receptor negatively regulates adipogenesis through Gαs-mediated microtubule disassembly and consequent activation of the Rho/ROCK pathway.

  9. Disassembly and removal of sodium instrumentation test loop

    International Nuclear Information System (INIS)

    Ishikawa, Okinobu; Onojima, Takamitu; Nagai, Keiichi

    2000-07-01

    In 1999, the Sodium Instrumentation Test Loop was disassembled and removed. This report describes the tasks and experiences obtained in removing sodium from a storage tank, disassembling, and cleansing components and related activities. Overall the disassembly, handling and cleansing tasks proceeded as planned and the activities were carried out efficiently and safely. Documentation of the process is meant to establish not only a procedure, but also a guideline for future similar tasks. (author)

  10. LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate.

    Science.gov (United States)

    Belluzzi, Elisa; Gonnelli, Adriano; Cirnaru, Maria-Daniela; Marte, Antonella; Plotegher, Nicoletta; Russo, Isabella; Civiero, Laura; Cogo, Susanna; Carrion, Maria Perèz; Franchin, Cinzia; Arrigoni, Giorgio; Beltramini, Mariano; Bubacco, Luigi; Onofri, Franco; Piccoli, Giovanni; Greggio, Elisa

    2016-01-13

    Lrrk2, a gene linked to Parkinson's disease, encodes a large scaffolding protein with kinase and GTPase activities implicated in vesicle and cytoskeletal-related processes. At the presynaptic site, LRRK2 associates with synaptic vesicles through interaction with a panel of presynaptic proteins. Here, we show that LRRK2 kinase activity influences the dynamics of synaptic vesicle fusion. We therefore investigated whether LRRK2 phosphorylates component(s) of the exo/endocytosis machinery. We have previously observed that LRRK2 interacts with NSF, a hexameric AAA+ ATPase that couples ATP hydrolysis to the disassembling of SNARE proteins allowing them to enter another fusion cycle during synaptic exocytosis. Here, we demonstrate that NSF is a substrate of LRRK2 kinase activity. LRRK2 phosphorylates full-length NSF at threonine 645 in the ATP binding pocket of D2 domain. Functionally, NSF phosphorylated by LRRK2 displays enhanced ATPase activity and increased rate of SNARE complex disassembling. Substitution of threonine 645 with alanine abrogates LRRK2-mediated increased ATPase activity. Given that the most common Parkinson's disease LRRK2 G2019S mutation displays increased kinase activity, our results suggest that mutant LRRK2 may impair synaptic vesicle dynamics via aberrant phosphorylation of NSF.

  11. Design for Disassembly

    DEFF Research Database (Denmark)

    Beim, Anne

    2018-01-01

    ‘Design for Disassembly’ is becoming a familiar part of discourses on environmental strategies for construction and sustainable design. The concept originates in industrial design and pertains to a wide range of strategies for reuse and recycling, all of which highlight a whole-of-life approach t...... to materials and buildings. Design for Disassembly is particularly relevant to prefabricated and industrialized construction; as such methodologies already contain within them the possibility for easy deconstruction, whether for maintenance, refurbishment or reuse....

  12. A Trio-Rac1-PAK1 signaling axis drives invadopodia disassembly

    Science.gov (United States)

    Moshfegh, Yasmin; Bravo-Cordero, Jose Javier; Miskolci, Veronika; Condeelis, John; Hodgson, Louis

    2014-01-01

    Rho family GTPases control cell migration and participate in the regulation of cancer metastasis. Invadopodia, associated with invasive tumor cells, are crucial for cellular invasion and metastasis. To study Rac1 GTPase in invadopodia dynamics, we developed a genetically-encoded, single-chain Rac1 Fluorescence Resonance Energy Transfer (FRET) biosensor. The biosensor shows Rac1 activity exclusion from the core of invadopodia, and higher activity when invadopodia disappear, suggesting that reduced Rac1 activity is necessary for their stability, and Rac1 activation is involved in disassembly. Photoactivating Rac1 at invadopodia confirmed this previously-unknown Rac1 function. We built an invadopodia disassembly model, where a signaling axis involving TrioGEF, Rac1, PAK1, and phosphorylation of cortactin, causing invadopodia dissolution. This mechanism is critical for the proper turnover of invasive structures during tumor cell invasion, where a balance of proteolytic activity and locomotory protrusions must be carefully coordinated to achieve a maximally invasive phenotype. PMID:24859002

  13. AGC-2 Disassembly Report

    Energy Technology Data Exchange (ETDEWEB)

    William Windes

    2014-05-01

    The Next Generation Nuclear Plant (NGNP) Graphite Research and Development (R&D) Program is currently measuring irradiated material properties for predicting the behavior and operating performance of new nuclear graphite grades available for use within the cores of new very high temperature reactor designs. The Advanced Graphite Creep (AGC) experiment, consisting of six irradiation capsules, will generate irradiated graphite performance data for NGNP reactor operating conditions. The AGC experiment is designed to determine the changes to specific material properties such as thermal diffusivity, thermal expansion, elastic modulus, mechanical strength, irradiation induced dimensional change rate, and irradiation creep for a wide variety of nuclear grade graphite types over a range of high temperature, and moderate doses. A series of six capsules containing graphite test specimens will be used to expose graphite test samples to a dose range from 1 to 7 dpa at three different temperatures (600, 900, and 1200°C) as described in the Graphite Technology Development Plan. Since irradiation induced creep within graphite components is considered critical to determining the operational life of the graphite core, some of the samples will also be exposed to an applied load to determine the creep rate for each graphite type under both temperature and neutron flux. All six AGC capsules in the experiment will be irradiated in the Advanced Test Reactor (ATR). AGC-1 and AGC-2 will be irradiated in the south flux trap and AGC-3–AGC-6 will be irradiated in the east flux trap. The change in flux traps is due to NGNP irradiation priorities requiring the AGC experiment to be moved to accommodate Fuel irradiation experiments. After irradiation, all six AGC capsules will be cooled in the ATR Canal, sized for shipment, and shipped to the Materials and Fuels Complex (MFC) where the capsule will be disassembled in the Hot Fuel Examination Facility (HFEF). During disassembly, the metallic

  14. HUWE1 Ubiquitylates and Degrades the RAC Activator TIAM1 Promoting Cell-Cell Adhesion Disassembly, Migration, and Invasion

    Directory of Open Access Journals (Sweden)

    Lynsey Vaughan

    2015-01-01

    Full Text Available The E3 ubiquitin ligase HUWE1, deregulated in carcinoma, has been implicated in tumor formation. Here, we uncover a role for HUWE1 in cell migration and invasion through degrading the RAC activator TIAM1, implying an additional function in malignant progression. In MDCKII cells in response to HGF, HUWE1 catalyzes TIAM1 ubiquitylation and degradation predominantly at cell-cell adhesions, facilitating junction disassembly, migration, and invasion. Depleting HUWE1 or mutating the TIAM1 ubiquitylation site prevents TIAM1 degradation, antagonizing scattering, and invasion. Moreover, simultaneous depletion of TIAM1 restores migration and invasion in HUWE1-depleted cells. Significantly, we show that HUWE1 stimulates human lung cancer cell invasion through regulating TIAM1 stability. Finally, we demonstrate that HUWE1 and TIAM1 protein levels are inversely correlated in human lung carcinomas. Thus, we elucidate a critical role for HUWE1 in regulating epithelial cell-cell adhesion and provide additional evidence that ubiquitylation contributes to spatiotemporal control of RAC.

  15. Disassembly of an arch bridge deformed due to landslide activity and the replacement of a new bridge in the same site. Jisuberi ni yori henkei shita arch bashi no kaitai to shinbashi no kakekae

    Energy Technology Data Exchange (ETDEWEB)

    Sano, S; Morimoto, C; Tomoda, T; Mizukawa, Y; Onushi, M; Ito, T [Kawasaki Heavy Industries, Ltd., Tokyo (Japan)

    1991-10-20

    This report describes the replacement process of an arch bridge deformed due to landslide activity, selection and contents of the disassembly method, and configuration of the new bridge and its design method. The Ryugu Bridge had been damaged by landslides over an extended period. It was a deck arch bridge having originally a span of 74 meters, but it had shortened by 424 mm due to landslide activity during 14 years since its completion. Then it was decided to be replaced by a new bridge having an adjustable structure to support the movement of its abutments. As disassembly of the deformed arch bridge could be dangerous, the best methodology was studied, and the disassembly was carried out by the cable method. The new bridge had box-girder parts in both side of the main truss, so as to be adjustable to the change of the span length, and the bridge was designed for a working life of 50 years if the bearing supports and expansion joints were reset every 10 years. Concerning the connecting parts between the box-girder and the main truss, appropriateness of the sectional configuration was verified by FEM analysis. 9 refs., 18 figs., 2 tab.

  16. Simulation-based disassembly systems design

    Science.gov (United States)

    Ohlendorf, Martin; Herrmann, Christoph; Hesselbach, Juergen

    2004-02-01

    Recycling of Waste of Electrical and Electronic Equipment (WEEE) is a matter of actual concern, driven by economic, ecological and legislative reasons. Here, disassembly as the first step of the treatment process plays a key role. To achieve sustainable progress in WEEE disassembly, the key is not to limit analysis and planning to merely disassembly processes in a narrow sense, but to consider entire disassembly plants including additional aspects such as internal logistics, storage, sorting etc. as well. In this regard, the paper presents ways of designing, dimensioning, structuring and modeling different disassembly systems. Goal is to achieve efficient and economic disassembly systems that allow recycling processes complying with legal requirements. Moreover, advantages of applying simulation software tools that are widespread and successfully utilized in conventional industry sectors are addressed. They support systematic disassembly planning by means of simulation experiments including consecutive efficiency evaluation. Consequently, anticipatory recycling planning considering various scenarios is enabled and decisions about which types of disassembly systems evidence appropriateness for specific circumstances such as product spectrum, throughput, disassembly depth etc. is supported. Furthermore, integration of simulation based disassembly planning in a holistic concept with configuration of interfaces and data utilization including cost aspects is described.

  17. Disassembling and rebuilding 900 MW unit fuel assemblies in Celimene

    International Nuclear Information System (INIS)

    Giquel, G.; Leseur, A.; Pillet, C.; Van Craeynest, J.C.

    1987-01-01

    The Celimene high activity laboratory, in the Nuclear Research Centre of Saclay, has equipment for and experience of disassembling and rebuilding fuel assemblies from 900 MW light water reactors. These operations have been performed for R and D purposes; they allow removal for investigation of some of the fuel rods and examination of the skeleton. The rebuilt assemblies are sent to the fuel reprocessing plant. Reirradiation of these assemblies has not been considered so far and would require modifications of the procedure and of parts of the new skeleton. Disassembling and rebuilding have already been performed on three assemblies and a fourth one will be rebuilt in the coming months [fr

  18. Montmorillonite-induced Bacteriophage φ6 Disassembly

    Science.gov (United States)

    Trusiak, A.; Gottlieb, P.; Katz, A.; Alimova, A.; Steiner, J. C.; Block, K. A.

    2012-12-01

    It is estimated that there are 1031 virus particles on Earth making viruses an order of magnitude more prevalent in number than prokaryotes with the vast majority of viruses being bacteriophages. Clays are a major component of soils and aquatic sediments and can react with RNA, proteins and bacterial biofilms. The clays in soils serve as an important moderator between phage and their host bacteria, helping to preserve the evolutionary balance. Studies on the effects of clays on viral infectivity have given somewhat contradictory results; possibly a consequence of clay-virus interactions being dependent on the unique structure of particular viruses. In this work, the interaction between montmorillonite and the bacteriophage φ6 is investigated. φ6 is a member of the cystovirus family that infects Pseudomonas syringe, a common plant pathogen. As a member of the cystovirus family with an enveloped structure, φ6 serves as a model for reoviruses, a human pathogen. Experiments were conducted with φ6 suspended in dilute, purified homoionic commercial-grade montmorillonite over a range of virus:clay ratios. At a 1:100000 virus:clay ratio, the clay reduced viral infectivity by 99%. The minimum clay to virus ratio which results in a measurable reduction of P. syringae infection is 1:1. Electron microscopy demonstrates that mixed suspensions of smectite and virus co-aggregate to form flocs encompassing virions within the smectite. Both free viral particles as well as those imbedded in the flocs are seen in the micrographs to be missing the envelope- leaving only the nucleocapsid (NC) intact; indicating that smectite inactivates the virus by envelope disassembly. These results have strong implications in the evolution of both the φ6 virus and its P. syringae host cells. TEM of aggregate showing several disassembled NCs.

  19. Microcanonical simulation of nuclear disassembly

    International Nuclear Information System (INIS)

    Koonin, S.E.; Randrup, J.

    1986-01-01

    There is considerable interest in the disassembly of the hot nuclear matter produced in high-energy nuclear collisions. A particular stimulus has been the prospect of observing a nuclear liquid-gas phase transition. On rather general grounds, such a transition is expected to occur in nuclear matter at subsaturation densities with temperatures of 10-20 MeV. However, virtually all previous discussions of this phenomenon have been based on thermodynamical considerations valid for infinite, non-interacting systems and the qualitative validity of the results has not been ascertained for the relatively small, finite, interacting systems of practical relevance. Nor is it clear how the occurrence of the phase transition will manifest itself in the asymptotically observed fragment distribution. To progress in these matters, the authors have formulated a microcanonical simulation of the disassembly process, including interfragment interactions. It is a natural refinement of the grand canonical model first presented in [1] and further developed in [2] and is also a exact version of the model developed in [3] for the generation of complete multifragment events in medium-energy collisions. In this contribution, the authors give a brief description of the key ingredients in the model and its numerical implementation

  20. Disassembly for remanufacturing: A systematic literature review, new model development and future research needs

    Directory of Open Access Journals (Sweden)

    Anjar Priyono

    2016-11-01

    Full Text Available Purpose: Disassembly is an important process that distinguishes remanufacturing from conventional manufacturing. It is a unique process that becomes focus of investigation from many scholars. Yet, most scholars investigate disassembly from technical and operational standpoint that lack of strategic perspective. This paper attempts to fill this gap by looking at disassembly from a strategic perspective by considering organisational characteristics, process choices and product attributes. To be more specific, this paper has three objectives. First, to gain understanding what has been done, and what need to be done in the field of disassembly in remanufacturing. Second, to conduct a systematic literature review for identifying the factors affecting disassembly for remanufacturing. Third, to propose a new model of disassembly for remanufacturing and also to provide avenues for future research. Design/methodology/approach: This study used a systematic literature review method. A series of steps were undertaken during the review. The study was started with determining the purpose of the study, selecting appropriate keywords, and reducing the selected papers using a number of criteria. A deeper analysis was carried out on the final paper that meets the criteria for this review. Findings: There are two main findings of this study. First, a list of factors affecting disassembly in remanufacturing is identified. The factors can be categorised into three groups: organisational factors, process choices and product attributes. Second, using factors that have been identified, a new model of disassembly process for remanufacturing is developed. Current studies only consider disassembly as a physical activity to break down products into components. In the new model, disassembly is viewed as a process that converts into into output, which consist of a series of steps. Research limitations/implications: The opportunities for future research include: the need to

  1. Disassembly for remanufacturing: A systematic literature review, new model development and future research needs

    International Nuclear Information System (INIS)

    Priyono, A.; Ijomah, W.; Bititci, U.

    2016-01-01

    Purpose: Disassembly is an important process that distinguishes remanufacturing from conventional manufacturing. It is a unique process that becomes focus of investigation from many scholars. Yet, most scholars investigate disassembly from technical and operational standpoint that lack of strategic perspective. This paper attempts to fill this gap by looking at disassembly from a strategic perspective by considering organisational characteristics, process choices and product attributes. To be more specific, this paper has three objectives. First, to gain understanding what has been done, and what need to be done in the field of disassembly in remanufacturing. Second, to conduct a systematic literature review for identifying the factors affecting disassembly for remanufacturing. Third, to propose a new model of disassembly for remanufacturing and also to provide avenues for future research. Design/methodology/approach: This study used a systematic literature review method. A series of steps were undertaken during the review. The study was started with determining the purpose of the study, selecting appropriate keywords, and reducing the selected papers using a number of criteria. A deeper analysis was carried out on the final paper that meets the criteria for this review. Findings: There are two main findings of this study. First, a list of factors affecting disassembly in remanufacturing is identified. The factors can be categorised into three groups: organisational factors, process choices and product attributes. Second, using factors that have been identified, a new model of disassembly process for remanufacturing is developed. Current studies only consider disassembly as a physical activity to break down products into components. In the new model, disassembly is viewed as a process that converts into into output, which consist of a series of steps. Research limitations/implications: The opportunities for future research include: the need to develop an index of

  2. Disassembly for remanufacturing: A systematic literature review, new model development and future research needs

    Energy Technology Data Exchange (ETDEWEB)

    Priyono, A.; Ijomah, W.; Bititci, U.

    2016-07-01

    Purpose: Disassembly is an important process that distinguishes remanufacturing from conventional manufacturing. It is a unique process that becomes focus of investigation from many scholars. Yet, most scholars investigate disassembly from technical and operational standpoint that lack of strategic perspective. This paper attempts to fill this gap by looking at disassembly from a strategic perspective by considering organisational characteristics, process choices and product attributes. To be more specific, this paper has three objectives. First, to gain understanding what has been done, and what need to be done in the field of disassembly in remanufacturing. Second, to conduct a systematic literature review for identifying the factors affecting disassembly for remanufacturing. Third, to propose a new model of disassembly for remanufacturing and also to provide avenues for future research. Design/methodology/approach: This study used a systematic literature review method. A series of steps were undertaken during the review. The study was started with determining the purpose of the study, selecting appropriate keywords, and reducing the selected papers using a number of criteria. A deeper analysis was carried out on the final paper that meets the criteria for this review. Findings: There are two main findings of this study. First, a list of factors affecting disassembly in remanufacturing is identified. The factors can be categorised into three groups: organisational factors, process choices and product attributes. Second, using factors that have been identified, a new model of disassembly process for remanufacturing is developed. Current studies only consider disassembly as a physical activity to break down products into components. In the new model, disassembly is viewed as a process that converts into into output, which consist of a series of steps. Research limitations/implications: The opportunities for future research include: the need to develop an index of

  3. Illustrating the disassembly of 3D models

    KAUST Repository

    Guo, Jianwei; Yan, Dongming; Li, Er; Dong, Weiming; Wonka, Peter; Zhang, Xiaopeng

    2013-01-01

    We present a framework for the automatic disassembly of 3D man-made models and the illustration of the disassembly process. Given an assembled 3D model, we first analyze the individual parts using sharp edge loops and extract the contact faces

  4. Balance Comparisons between Female Dancers and Active Nondancers

    Science.gov (United States)

    Ambegaonkar, Jatin P.; Caswell, Shane V.; Winchester, Jason B.; Shimokochi, Yohei; Cortes, Nelson; Caswell, Amanda M.

    2013-01-01

    Purpose: Female dancers have lower anterior cruciate ligament (ACL) injury rates compared with physically active women. Enhanced balance can decrease musculoskeletal injury risk. Dancers are proposed to have superior balance compared with physically active nondancers, and this may reduce their risk for ACL injury. However, whether female dancers…

  5. Large enhancement of functional activity of active site-inhibited factor VIIa due to protein dimerization: insights into mechanism of assembly/disassembly from tissue factor.

    Science.gov (United States)

    Stone, Matthew D; Harvey, Stephen B; Martinez, Michael B; Bach, Ronald R; Nelsestuen, Gary L

    2005-04-26

    Active site-inhibited blood clotting factor VIIa (fVIIai) binds to tissue factor (TF), a cell surface receptor that is exposed upon injury and initiates the blood clotting cascade. FVIIai blocks binding of the corresponding enzyme (fVIIa) or zymogen (fVII) forms of factor VII and inhibits coagulation. Although several studies have suggested that fVIIai may have superior anticoagulation effects in vivo, a challenge for use of fVIIai is cost of production. This study reports the properties of dimeric forms of fVIIai that are cross-linked through their active sites. Dimeric wild-type fVIIai was at least 75-fold more effective than monomeric fVIIai in blocking fVIIa association with TF. The dimer of a mutant fVIIai with higher membrane affinity was 1600-fold more effective. Anticoagulation by any form of fVIIai differed substantially from agents such as heparin and showed a delayed mode of action. Coagulation proceeded normally for the first minutes, and inhibition increased as equilibrium binding was established. It is suggested that association of fVIIa(i) with TF in a collision-dependent reaction gives equal access of inhibitor and enzyme to TF. Assembly was not influenced by the higher affinity and slower dissociation of the dimer. As a result, anticoagulation was delayed until the reaction reached equilibrium. Properties of different dissociation experiments suggested that dissociation of fVIIai from TF occurred by a two-step mechanism. The first step was separation of TF-fVIIa(i) while both proteins remained bound to the membrane, and the second step was dissociation of the fVIIa(i) from the membrane. These results suggest novel actions of fVIIai that distinguish it from most of the anticoagulants that block later steps of the coagulation cascade.

  6. Disassembly automation automated systems with cognitive abilities

    CERN Document Server

    Vongbunyong, Supachai

    2015-01-01

    This book presents a number of aspects to be considered in the development of disassembly automation, including the mechanical system, vision system and intelligent planner. The implementation of cognitive robotics increases the flexibility and degree of autonomy of the disassembly system. Disassembly, as a step in the treatment of end-of-life products, can allow the recovery of embodied value left within disposed products, as well as the appropriate separation of potentially-hazardous components. In the end-of-life treatment industry, disassembly has largely been limited to manual labor, which is expensive in developed countries. Automation is one possible solution for economic feasibility. The target audience primarily comprises researchers and experts in the field, but the book may also be beneficial for graduate students.

  7. Balancing Openness and Interpretation in Active Listening

    Science.gov (United States)

    Topornycky, Joseph; Golparian, Shaya

    2016-01-01

    Active listening is an important communication skill in a variety of disciplines and professions, including the profession of Educational Development. In our roles as educational developers, we engage in a variety of processes, all of which rely heavily on the practice of active listening. Emerging strategies of active listening praxis have…

  8. BALANCE

    Science.gov (United States)

    Carmichael, H.

    1953-01-01

    A torsional-type analytical balance designed to arrive at its equilibrium point more quickly than previous balances is described. In order to prevent external heat sources creating air currents inside the balance casing that would reiard the attainment of equilibrium conditions, a relatively thick casing shaped as an inverted U is placed over the load support arms and the balance beam. This casing is of a metal of good thernnal conductivity characteristics, such as copper or aluminum, in order that heat applied to one portion of the balance is quickly conducted to all other sensitive areas, thus effectively preventing the fornnation of air currents caused by unequal heating of the balance.

  9. Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines.

    Science.gov (United States)

    Monroe, Nicole; Hill, Christopher P

    2016-05-08

    Meiotic clade AAA ATPases (ATPases associated with diverse cellular activities), which were initially grouped on the basis of phylogenetic classification of their AAA ATPase cassette, include four relatively well characterized family members, Vps4, spastin, katanin and fidgetin. These enzymes all function to disassemble specific polymeric protein structures, with Vps4 disassembling the ESCRT-III polymers that are central to the many membrane-remodeling activities of the ESCRT (endosomal sorting complexes required for transport) pathway and spastin, katanin p60 and fidgetin affecting multiple aspects of cellular dynamics by severing microtubules. They share a common domain architecture that features an N-terminal MIT (microtubule interacting and trafficking) domain followed by a single AAA ATPase cassette. Meiotic clade AAA ATPases function as hexamers that can cycle between the active assembly and inactive monomers/dimers in a regulated process, and they appear to disassemble their polymeric substrates by translocating subunits through the central pore of their hexameric ring. Recent studies with Vps4 have shown that nucleotide-induced asymmetry is a requirement for substrate binding to the pore loops and that recruitment to the protein lattice via MIT domains also relieves autoinhibition and primes the AAA ATPase cassettes for substrate binding. The most striking, unifying feature of meiotic clade AAA ATPases may be their MIT domain, which is a module that is found in a wide variety of proteins that localize to ESCRT-III polymers. Spastin also displays an adjacent microtubule binding sequence, and the presence of both ESCRT-III and microtubule binding elements may underlie the recent findings that the ESCRT-III disassembly function of Vps4 and the microtubule-severing function of spastin, as well as potentially katanin and fidgetin, are highly coordinated. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. Generation of control sequences for a pilot-disassembly system

    Science.gov (United States)

    Seliger, Guenther; Kim, Hyung-Ju; Keil, Thomas

    2002-02-01

    Closing the product and material cycles has emerged as a paradigm for industry in the 21st century. Disassembly plays a key role in a life cycle economy since it enables the recovery of resources. A partly automated disassembly system should adapt to a large variety of products and different degrees of devaluation. Also the amounts of products to be disassembled can vary strongly. To cope with these demands an approach to generate on-line disassembly control sequences will be presented. In order to react on these demands the technological feasibility is considered within a procedure for the generation of disassembly control sequences. Procedures are designed to find available and technologically feasible disassembly processes. The control system is formed by modularised and parameterised control units in the cell level within the entire control architecture. In the first development stage product and process analyses at the sample product washing machine were executed. Furthermore a generalized disassembly process was defined. Afterwards these processes were structured in primary and secondary functions. In the second stage the disassembly control at the technological level was investigated. Factors were the availability of the disassembly tools and the technological feasibility of the disassembly processes within the disassembly system. Technical alternative disassembly processes are determined as a result of availability of the tools and technological feasibility of processes. The fourth phase was the concept for the generation of the disassembly control sequences. The approach will be proved in a prototypical disassembly system.

  11. Recycling of electrical motors by automatic disassembly

    Science.gov (United States)

    Karlsson, Björn; Järrhed, Jan-Ove

    2000-04-01

    This paper presents a robotized workstation for end-of-life treatment of electrical motors with an electrical effect of about 1 kW. These motors can, for example, be found in washing machines and in industry. There are two main steps in the work. The first step is an inspection whereby the functionality of the motor is checked and classification either for re-use or for disassembly is done. In the second step the motors classified for disassembly are disassembled in a robotized automatic station. In the initial step measurements are performed during a start-up sequence of about 1 s. By measuring the rotation speed and the current and voltage of the three phases of the motor classification for either reuse or disassembly can be done. During the disassembly work, vision data are fused in order to classify the motors according to their type. The vision system also feeds the control system of the robot with various object co-ordinates, to facilitate correct operation of the robot. Finally, tests with a vision system and eddy-current equipment are performed to decide whether all copper has been removed from the stator.

  12. Complement activation and inhibition: a delicate balance

    DEFF Research Database (Denmark)

    Sjöberg, A P; Trouw, L A; Blom, A M

    2009-01-01

    proteins, pentraxins, amyloid deposits, prions and DNA, all bind the complement activator C1q, but also interact with complement inhibitors C4b-binding protein and factor H. This contrasts to the interaction between C1q and immune complexes, in which case no inhibitors bind, resulting in full complement...

  13. Illustrating the disassembly of 3D models

    KAUST Repository

    Guo, Jianwei

    2013-06-11

    We present a framework for the automatic disassembly of 3D man-made models and the illustration of the disassembly process. Given an assembled 3D model, we first analyze the individual parts using sharp edge loops and extract the contact faces between each pair of neighboring parts. The contact faces are then used to compute the possible moving directions of each part. We then present a simple algorithm for clustering the sets of the individual parts into meaningful sub-assemblies, which can be used for a hierarchical decomposition. We take the stability of sub-assemblies into account during the decomposition process by considering the upright orientation of the input models. Our framework also provides a user-friendly interface to enable the superimposition of the constraints for the decomposition. Finally, we visualize the disassembly process by generating an animated sequence. The experiments demonstrate that our framework works well for a variety of complex models. © 2013 Elsevier Ltd.

  14. Nuclear fuel bundle disassembly and assembly tool

    International Nuclear Information System (INIS)

    Yates, J.; Long, J.W.

    1975-01-01

    A nuclear power reactor fuel bundle is described which has a plurality of tubular fuel rods disposed in parallel array between two transverse tie plates. It is secured against disassembly by one or more locking forks which engage slots in tie rods which position the transverse plates. Springs mounted on the fuel and tie rods are compressed when the bundle is assembled thereby maintaining a continual pressure against the locking forks. Force applied in opposition to the springs permits withdrawal of the locking forks so that one tie plate may be removed, giving access to the fuel rods. An assembly and disassembly tool facilitates removal of the locking forks when the bundle is to be disassembled and the placing of the forks during assembly of the bundle. (U.S.)

  15. Flexibility and Balancing in Active Distribution Networks

    DEFF Research Database (Denmark)

    Kordheili, Reza Ahmadi

    . Chapter 4 presents the details of the analysis, as well as the details of the MV network. To generalize the analysis, a standard MV network has been used for the studies. The MV network is also an active network, i.e. it involves MV wind turbines and decentralized combined heat and power (DCHP). DCHP...... units play an important role in Danish power system, and they contribute to electricity production as well. Modeling of wind turbines is done considering real data of a Vestas wind turbine. For wind speed, a modified wind speed model has been used for wind turbines, considering the available wind...... measurement. Also, a detailed model of DCHP units has been used in this thesis. Details of wind turbine model, as well as details of DCHP are presented in the thesis. The third objective of the research is to include the LV and MV networks in frequency response of the power system. Considering the increasing...

  16. Methods for otpimum and near optimum disassembly sequencing

    NARCIS (Netherlands)

    Lambert, A.J.D.; Gupta, S.M.

    2008-01-01

    This paper considers disassembly sequencing problems subjected to sequence dependent disassembly costs. In practice, the methods for dealing with such problems rely mainly on metaheuristic and heuristic methods, which intrinsically generate suboptimum solutions. Exact methods are NP-hard and

  17. SAVANNAH RIVER SITE R REACTOR DISASSEMBLY BASIN IN SITU DECOMMISSIONING

    Energy Technology Data Exchange (ETDEWEB)

    Langton, C.; Blankenship, J.; Griffin, W.; Serrato, M.

    2009-12-03

    The US DOE concept for facility in-situ decommissioning (ISD) is to physically stabilize and isolate in tact, structurally sound facilities that are no longer needed for their original purpose of, i.e., generating (reactor facilities), processing(isotope separation facilities) or storing radioactive materials. The 105-R Disassembly Basin is the first SRS reactor facility to undergo the in-situ decommissioning (ISD) process. This ISD process complies with the105-R Disassembly Basin project strategy as outlined in the Engineering Evaluation/Cost Analysis for the Grouting of the R-Reactor Disassembly Basin at the Savannah River Site and includes: (1) Managing residual water by solidification in-place or evaporation at another facility; (2) Filling the below grade portion of the basin with cementitious materials to physically stabilize the basin and prevent collapse of the final cap - Sludge and debris in the bottom few feet of the basin will be encapsulated between the basin floor and overlying fill material to isolate if from the environment; (3) Demolishing the above grade portion of the structure and relocating the resulting debris to another location or disposing of the debris in-place; and (4) Capping the basin area with a concrete slab which is part of an engineered cap to prevent inadvertent intrusion. The estimated total grout volume to fill the 105-R Reactor Disassembly Basin is 24,424 cubic meters or 31,945 cubic yards. Portland cement-based structural fill materials were design and tested for the reactor ISD project and a placement strategy for stabilizing the basin was developed. Based on structural engineering analyses and work flow considerations, the recommended maximum lift height is 5 feet with 24 hours between lifts. Pertinent data and information related to the SRS 105-R-Reactor Disassembly Basin in-situ decommissioning include: regulatory documentation, residual water management, area preparation activities, technology needs, fill material designs

  18. Task-failure-driven rebalancing of disassembly lines

    OpenAIRE

    Altekin, Fatma Tevhide; Akkan, Can

    2011-01-01

    Many reverse-logistics systems that collect and reprocess end-of-life products require a disassembly stage. The nature of variability in incoming products, and damages, which are more likely to occur during disassembly than assembly, create a significant uncertainty in disassembly tasks, namely, possibility of failed tasks. Such failures may lead to some successor tasks being infeasible, which changes work contents of downstream stations. To improve the profitability of such a disassembly lin...

  19. Multi-kanban mechanism for appliance disassembly

    Science.gov (United States)

    Udomsawat, Gun; Gupta, Surendra M.

    2005-11-01

    The use of household appliances continues to rise every year. A significant number of End-Of-Life (EOL) appliances are generated because of the introduction of newer models that are more attractive, efficient and affordable. Others are, of course, generated when they become non-functional. Many regulations encourage recycling of EOL appliances to reduce the amount of waste sent to landfills. In addition, EOL appliances offer the appliance manufacturing and remanufacturing industries a source of less expensive raw materials and components. For this reason product recovery has become a subject of interest during the past decade. In this paper, we study the disassembly line for appliance disassembly. We discuss and incorporate some of the complications that are inherent in disassembly line including product arrival, demand arrival, inventory fluctuation and production control mechanisms. We show how to overcome such complications by implementing a multi-kanban system in the appliance disassembly line setting. The multi-kanban system (MKS) relies on dynamic routing of kanbans according to the state of the system. We investigate the multi-kanban mechanism using simulation and explore the effect of product mix on performance of the traditional push system (TPS) and MKS in terms of controlling the system's inventory while attempting to achieve a decent customer service level.

  20. Active video gaming to improve balance in the elderly

    NARCIS (Netherlands)

    Lamoth, C.J.; Caljouw, S.R.; Postema, K.

    2011-01-01

    The combination of active video gaming and exercise (exergaming) is suggested to improve elderly people's balance, thereby decreasing fall risk. Exergaming has been shown to increase motivation during exercise therapy, due to the enjoyable and challenging nature, which could support long-term

  1. [6]-Gingerol Prevents Disassembly of Cell Junctions and Activities of MMPs in Invasive Human Pancreas Cancer Cells through ERK/NF-κB/Snail Signal Transduction Pathway

    Directory of Open Access Journals (Sweden)

    Sung Ok Kim

    2013-01-01

    Full Text Available To study the effects of [6]-gingerol, a ginger phytochemical, on tight junction (TJ molecules, we investigated TJ tightening and signal transduction pathways in human pancreatic duct cell-derived cancer cell line PANC-1. The following methods were utilized: MTT assay to determine cytotoxicity; zymography to examine matrix metalloproteinase (MMP activities; transepithelial electrical resistance (TER and paracellular flux for TJ measurement; RT-PCR and immunoblotting for proteins related to TJ and invasion; and EMSA for NF-κB activity in PANC-1 cells. Results revealed that TER significantly increased and claudin 4 and MMP-9 decreased compared to those of the control. TJ protein levels, including zonula occludens (ZO- 1, occludin, and E-cadherin, increased in [6]-gingerol-treated cells, which correlated with a decrease in paracellular flux and MMP activity. Furthermore, NF-κB/Snail nuclear translocation was suppressed via downregulation of the extracellular signal-regulated kinase (ERK pathway in response to [6]-gingerol treatment. Moreover, treatment with U0126, an ERK inhibitor, completely blocked NF-κB activity. In conclusion, these findings demonstrate that [6]-gingerol regulates TJ-related proteins and suppresses invasion and metastasis through NF-κB/Snail inhibition via inhibition of the ERK pathway. Therefore, [6]-gingerol may suppress the invasive activity of PANC-1 cells.

  2. Balancing passive and active systems for evolutionary water cooled reactors

    International Nuclear Information System (INIS)

    Fil, N.S.; Allen, P.J.; Kirmse, R.E.; Kurihara, M.; Oh, S.J.; Sinha, R.K.

    1999-01-01

    Advanced concepts of the water-cooled reactors are intended to improve safety, economics and public perception of nuclear power. The potential inclusion of new passive means in addition or instead of traditional active systems is being considered by nuclear plant designers to reach these goals. With respect to plant safety, application of the passive means is mainly intended to simplify the safety systems and to improve their reliability, to mitigate the effect of human errors and equipment malfunction. However, some clear drawbacks and the limited experience and testing of passive systems may raise additional questions that have to be addressed in the design process for each advanced reactor. Therefore the plant designer should find a reasonable balance of active and passive means to effectively use their advantages and compensate their drawbacks. Some considerations that have to be taken into account when balancing active/passive means in advanced water-cooled reactors are discussed in this paper. (author)

  3. Accomplishment of JT-60U disassembly work dealing with radioactive components

    International Nuclear Information System (INIS)

    Ikeda, Yoshitaka

    2015-01-01

    The upgrade of the JT-60U to the superconducting tokamak 'JT-60SA' has been carried out to contribute the early realization of fusion energy by addressing key physics issues relevant for ITER and DEMO. Disassembly of the JT-60U tokamak was required so as to newly install the JT-60SA torus at the same position in the torus hall. The JT-60U tokamak was featured by the complicated and welded structure against the strong electromagnetic force, and by the radioactivation due to deuterium-deuterium (D-D) reactions of 1.5x10"2"0 (n) in total. Since this work was the first experience of disassembling a large radioactivated fusion device in Japan, careful preparations of disassembly activities, including treatment of the radioactivated materials and safety work, have been made. About 13,000 components with a total weight of more than 5,400 tonnes were removed from the torus hall and stored safely in storage facilities. All disassembly components were stored with recording the data such as dose rate, weight and kind of material, so as to apply the clearance level regulation in future. It was confirmed that the main radioactive material of the disassembly components was the stainless steel and that its dose rate was almost background level (∼0.1 μSv/h) at ∼10 m far from the vacuum vessel. It seems that the disassembly components with background dose level are in the clearance level. The assembly of JT-60SA tokamak has started in January 2013 after this disassembly of the JT-60U tokamak. (author)

  4. Passive force balancing of an active magnetic regenerative liquefier

    Science.gov (United States)

    Teyber, R.; Meinhardt, K.; Thomsen, E.; Polikarpov, E.; Cui, J.; Rowe, A.; Holladay, J.; Barclay, J.

    2018-04-01

    Active magnetic regenerators (AMR) have the potential for high efficiency cryogen liquefaction. One active magnetic regenerative liquefier (AMRL) configuration consists of dual magnetocaloric regenerators that reciprocate in a persistent-mode superconducting solenoid. Issues with this configuration are the spatial and temporal magnetization gradients that induce large magnetic forces and winding currents. To solve the coupled problem, we present a force minimization approach using passive magnetic material to balance a dual-regenerator AMR. A magnetostatic model is developed and simulated force waveforms are compared with experimental measurements. A genetic algorithm identifies force-minimizing passive structures with virtually ideal balancing characteristics. Implementation details are investigated which affirm the potential of the proposed methodology.

  5. [Relation between physical activity, weight balance and breast cancer].

    Science.gov (United States)

    Maître, Carole

    2013-05-01

    Many epidemiologic studies, with a good methodology, support the evidence of the positive role of regular physical activity on primary and tertiary prevention of breast cancer on the risk of recurrence and mortality. This relation depends on the level of total energy expenditure by week, which helps balance weight on lifetime, an essential part of benefit. The beneficial effects of physical activity are linked to many interrelated additional mechanisms: in a short-term, contraction of skeletal muscles involves aerobic metabolism which utilizes glucose and amino acids like glutamine, improves insulin sensitivity and lowers plasma insulin; in a long-term, physical activity produces favorable changes in body composition, decreasing body fat and increasing lean mass. That is a key point to reduce the intake of energy substrates stimulating carcinogenesis, to improve insulin sensitivity, to change the ratio of leptin and adiponectin, to enhance cellular immunity and to block cellular pathways of cell proliferation and angiogenesis. Maintaining a healthy weight through regular physical activity well balanced with energy intake is it a goal for prevention of breast cancer. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  6. Phosphorylation and disassembly of intermediate filaments in mitotic cells

    International Nuclear Information System (INIS)

    Chou, Yinghao; Rosevear, E.; Goldman, R.D.

    1989-01-01

    As baby hamster kidney (BHK-21) cells enter mitosis, networks of intermediate filaments (IFs) are transformed into cytoplasmic aggregates of protofilaments. Coincident with this morphological change, the phosphate content of vimentin increases from 0.3 mol of P i per mol of protein in interphase to 1.9 mol of P i per mol of protein in mitosis. A similar increase in phosphate content is observed with desmin, from 0.5 mol of P i per mol of protein to 1.5 mol of P i per mol of protein. Fractionation of mitotic cell lysates by hydroxylapatite column chromatography reveals the presence of two IF protein kinase activities, designated as IF protein kinase I and IF protein kinase II. Comparison of two-dimensional 32 P-labeled phosphopeptide maps of vimentin and desmin phosphorylated in vivo in mitosis, and in vitro using partially purified kinase fractions, reveals extensive similarity in the two sets of phosphorylation sites. Phosphorylation of in vitro polymerized IFs by IF protein kinase II induces complete disassembly as determined by negative-stain electron microscopy. The results support the idea that the disassembly of IFs in mitosis is regulated by the phosphorylation of its subunit proteins

  7. Assembly and disassembly of the nucleolus during the cell cycle.

    Science.gov (United States)

    Hernandez-Verdun, Danièle

    2011-01-01

    The nucleolus is a large nuclear domain in which transcription, maturation and assembly of ribosomes take place. In higher eukaryotes, nucleolar organization in three sub-domains reflects the compartmentation of the machineries related to active or inactive transcription of the ribosomal DNA, ribosomal RNA processing and assembly with ribosomal proteins of the two (40S and 60S) ribosomal subunits. The assembly of the nucleoli during telophase/early G(1) depends on pre-existing machineries inactivated during prophase (the transcription machinery and RNP processing complexes) and on partially processed 45S rRNAs inherited throughout mitosis. In telophase, the 45S rRNAs nucleate the prenucleolar bodies and order the dynamics of nucleolar assembly. The assembly/disassembly processes of the nucleolus depend on the equilibrium between phosphorylation/dephosphorylation of the transcription machinery and on the RNP processing complexes under the control of the CDK1-cyclin B kinase and PP1 phosphatases. The dynamics of assembly/disassembly of the nucleolus is time and space regulated.

  8. Active polarization imaging system based on optical heterodyne balanced receiver

    Science.gov (United States)

    Xu, Qian; Sun, Jianfeng; Lu, Zhiyong; Zhou, Yu; Luan, Zhu; Hou, Peipei; Liu, liren

    2017-08-01

    Active polarization imaging technology has recently become the hot research field all over the world, which has great potential application value in the military and civil area. By introducing active light source, the Mueller matrix of the target can be calculated according to the incident light and the emitted or reflected light. Compared with conventional direct detection technology, optical heterodyne detection technology have higher receiving sensitivities, which can obtain the whole amplitude, frequency and phase information of the signal light. In this paper, an active polarization imaging system will be designed. Based on optical heterodyne balanced receiver, the system can acquire the horizontal and vertical polarization of reflected optical field simultaneously, which contain the polarization characteristic of the target. Besides, signal to noise ratio and imaging distance can be greatly improved.

  9. Multikanban model for disassembly line with demand fluctuation

    Science.gov (United States)

    Udomsawat, Gun; Gupta, Surendra M.; Al-Turki, Yousef A. Y.

    2004-02-01

    In recent years, the continuous growth in consumer waste and dwindling natural resources has seriously threatened the environment. Realizing this, several countries have passed regulations that force manufacturers not only to manufacture environmentally conscious products, but also to take back their used products from consumers so that the components and materials recovered from the products may be reused and/or recycled. Disassembly plays an important role in product recovery. A disassembly line is perhaps the most suitable setting for disassembly of products in large quantities. Because a disassembly line has a tendency to generate excessive inventory, employing a kanban system can reduce the inventory level and let the system run more efficiently. A disassembly line is quite different from an assembly line. For example, not only can the demand arrive at the last station, it can also arrive at any of the other stations in the system. The demand for a component on the disassembly line could fluctuate widely. In fact, there are many other complicating matters that need to be considered to implement the concept of kanbans in such an environment. In this paper, we discuss the complications that are unique to a disassembly line. We discuss the complications in utilizing the conventional production control mechanisms in a disassembly line setting. We then show how to overcome them by implementing kanbans in a disassembly line setting with demand fluctuation and introduce the concept of multi-kanban mechanism. We demonstrate its effectiveness using a simulation model. An example is presented to illustrate the concept.

  10. The assembly and disassembly of ecological networks.

    Science.gov (United States)

    Bascompte, Jordi; Stouffer, Daniel B

    2009-06-27

    Global change has created a severe biodiversity crisis. Species are driven extinct at an increasing rate, and this has the potential to cause further coextinction cascades. The rate and shape of these coextinction cascades depend very much on the structure of the networks of interactions across species. Understanding network structure and how it relates to network disassembly, therefore, is a priority for system-level conservation biology. This process of network collapse may indeed be related to the process of network build-up, although very little is known about both processes and even less about their relationship. Here we review recent work that provides some preliminary answers to these questions. First, we focus on network assembly by emphasizing temporal processes at the species level, as well as the structural building blocks of complex ecological networks. Second, we focus on network disassembly as a consequence of species extinctions or habitat loss. We conclude by emphasizing some general rules of thumb that can help in building a comprehensive framework to understand the responses of ecological networks to global change.

  11. Relationship between balance and physical activity measured by an activity monitor in elderly COPD patients

    Directory of Open Access Journals (Sweden)

    Iwakura M

    2016-07-01

    Full Text Available Masahiro Iwakura,1,2 Kazuki Okura,2 Kazuyuki Shibata,1,2 Atsuyoshi Kawagoshi,2 Keiyu Sugawara,2 Hitomi Takahashi,2 Takanobu Shioya1 1Department of Rehabilitation, Akita City Hospital, 2Department of Physical Therapy, Akita University Graduate School of Health Sciences, Akita, Japan Background: Little is known regarding the relationship between balance impairments and physical activity in COPD. There has been no study investigating the relationship between balance and objectively measured physical activity. Here we investigated the association between balance and physical activity measured by an activity monitor in elderly COPD patients. Materials and methods: Twenty-two outpatients with COPD (mean age, 72±7 years; forced expiratory volume in 1 second, 53%±21% predicted and 13 age-matched healthy control subjects (mean age, 72±6 years participated in the study. We assessed all 35 subjects’ balance (one-leg standing test [OLST] times, Short Physical Performance Battery total scores, standing balance test scores, 4 m gait speed, and five-times sit-to-stand test [5STST] and physical activity (daily steps and time spent in moderate-to-vigorous physical activity per day [MV-PA]. Possible confounders were assessed in the COPD group. The between-group differences in balance test scores and physical activity were analyzed. A correlation analysis and multivariate regression analysis were conducted in the COPD group. Results: The COPD patients exhibited significant reductions in OLST times (P=0.033, Short Physical Performance Battery scores (P=0.013, 4 m gait speed (P<0.001, five-times sit-to-stand times (P=0.002, daily steps (P=0.003, and MV-PA (P=0.022 compared to the controls; the exception was the standing balance test scores. The correlation and multivariate regression analyses revealed significant independent associations between OLST times and daily steps (P<0.001 and between OLST times and MV-PA (P=0.014 in the COPD group after adjusting for

  12. Relationship between balance and physical activity measured by an activity monitor in elderly COPD patients

    OpenAIRE

    Iwakura, Masahiro; Okura, Kazuki; Shibata, Kazuyuki; Kawagoshi, Atsuyoshi; Sugawara, Keiyu; Takahashi, Hitomi; Shioya, Takanobu

    2016-01-01

    Masahiro Iwakura,1,2 Kazuki Okura,2 Kazuyuki Shibata,1,2 Atsuyoshi Kawagoshi,2 Keiyu Sugawara,2 Hitomi Takahashi,2 Takanobu Shioya1 1Department of Rehabilitation, Akita City Hospital, 2Department of Physical Therapy, Akita University Graduate School of Health Sciences, Akita, Japan Background: Little is known regarding the relationship between balance impairments and physical activity in COPD. There has been no study investigating the relationship between balance and objectively measured ph...

  13. Phosphatase PP2A and microtubule-mediated pulling forces disassemble centrosomes during mitotic exit

    Directory of Open Access Journals (Sweden)

    Stephen J. Enos

    2018-01-01

    Full Text Available Centrosomes are microtubule-nucleating organelles that facilitate chromosome segregation and cell division in metazoans. Centrosomes comprise centrioles that organize a micron-scale mass of protein called pericentriolar material (PCM from which microtubules nucleate. During each cell cycle, PCM accumulates around centrioles through phosphorylation-mediated assembly of PCM scaffold proteins. During mitotic exit, PCM swiftly disassembles by an unknown mechanism. Here, we used Caenorhabditis elegans embryos to determine the mechanism and importance of PCM disassembly in dividing cells. We found that the phosphatase PP2A and its regulatory subunit SUR-6 (PP2ASUR-6, together with cortically directed microtubule pulling forces, actively disassemble PCM. In embryos depleted of these activities, ∼25% of PCM persisted from one cell cycle into the next. Purified PP2ASUR-6 could dephosphorylate the major PCM scaffold protein SPD-5 in vitro. Our data suggest that PCM disassembly occurs through a combination of dephosphorylation of PCM components and force-driven fragmentation of the PCM scaffold.

  14. Disassembly and Sanitization of Classified Matter

    International Nuclear Information System (INIS)

    Stockham, Dwight J.; Saad, Max P.

    2008-01-01

    The Disassembly Sanitization Operation (DSO) process was implemented to support weapon disassembly and disposition by using recycling and waste minimization measures. This process was initiated by treaty agreements and reconfigurations within both the DOD and DOE Complexes. The DOE is faced with disassembling and disposing of a huge inventory of retired weapons, components, training equipment, spare parts, weapon maintenance equipment, and associated material. In addition, regulations have caused a dramatic increase in the need for information required to support the handling and disposition of these parts and materials. In the past, huge inventories of classified weapon components were required to have long-term storage at Sandia and at many other locations throughout the DoE Complex. These materials are placed in onsite storage unit due to classification issues and they may also contain radiological and/or hazardous components. Since no disposal options exist for this material, the only choice was long-term storage. Long-term storage is costly and somewhat problematic, requiring a secured storage area, monitoring, auditing, and presenting the potential for loss or theft of the material. Overall recycling rates for materials sent through the DSO process have enabled 70 to 80% of these components to be recycled. These components are made of high quality materials and once this material has been sanitized, the demand for the component metals for recycling efforts is very high. The DSO process for NGPF, classified components established the credibility of this technique for addressing the long-term storage requirements of the classified weapons component inventory. The success of this application has generated interest from other Sandia organizations and other locations throughout the complex. Other organizations are requesting the help of the DSO team and the DSO is responding to these requests by expanding its scope to include Work-for- Other projects. For example

  15. Workshop on instrumentation of the disassembled BER II

    International Nuclear Information System (INIS)

    Jauch, W.; Steiner, M.

    1982-01-01

    A workshop on the instrumentation of a disassembled BER II-reactor took place in the Hahn-Meitner-Institute in Berlin on April 19 and 20, 1982. Invited were all groups that are promoted by the associations 'Neutron Scattering for Investigation of Condensed Substance' and 'Neutron Scattering and Complementary Methods in Chemistry and Biology', along with experts for neutron spectrometers. 40 foreign scientists from 22 different institutes had accepted the invitation. The actual questions were treated in 13 presentations and a certain number of posters, with the latter also comprising activation analysis. The present report contains the presentations submitted, the final discussion minutes and a summary from HMI-view. (orig./RW) [de

  16. Disassembling and modification of RA-3

    International Nuclear Information System (INIS)

    Tarizzo, R.D.

    1990-01-01

    The objective of this paper is to describe the partial disassembling and modification of RA-3, called the Modernization Project. It comprises all the technical and administrative steps directly related with this task. The improvement of RA-3 is a result of the lack of 90% enriched uranium obliging a change over to 20% enriched uranium. This brought about design modifications both in fuel elements and the reactor. The presentation of documents for the licensing authority as well as are detailed separately. The modernization project was divided in 25 tasks: 1) changing fuel element support table, 2) changing heat exchanger, 3) repairing of cooling towers, 4) repairing of primary circuit valves, 5) repairing of irradiation channels, 6) construction of a new sampler, 7) changing tangential channel, 8) cleaning and disassembling of reactor (inside), 9) changing continuous demineralizer (ion exchange column), 10) detection of failure in fuel elements, 11) modification of nuclear instrumentation, 12) modification of conventional instrumentation, 13) modification of electrical system, 14) changing telemanipulators, 15) construction of mechanism bridge, 16) changing a primary circuit valve when the heat exchanger is changed too, 17) painting ground floor, hall floor, and pump room floor with epoxy resin levelling, 18) installation of fire alarm system, 19) radioactive liquid discharge, 20) modification of secondary circuit (This task involves: a) installation of a third secondary pump, b) extension of this piping, c) installation of two 12 inch valves to the present cooling towers pools independent, d) installation of filtering system), 21) optimization hot water bed, 22) changing detector support table, 23) removal, decontamination and reinstallation of shielding, 25) changing pneumatic system

  17. Optimization of Two-Level Disassembly/Remanufacturing/Assembly System with an Integrated Maintenance Strategy

    Directory of Open Access Journals (Sweden)

    Zouhour Guiras

    2018-04-01

    Full Text Available With an increase of environmental pressure on economic activities, reverse flow is increasingly important. It seeks to save resources, eliminate waste, and improve productivity. This paper investigates the optimization of the disassembly, remanufacturing and assembly system, taking into account assembly-disassembly system degradation. An analytical model is developed to consider disassembly, remanufacturing of used/end-of-life product and assembly of the finished product. The finished product is composed of remanufactured and new components. A maintenance policy is sequentially integrated to reduce the system unavailability. The aim of this study is to help decision-makers, under certain conditions, choose the most cost-effective process for them to satisfy the customer as well as to adapt to the potential risk that can perturb the disassembly-assembly system. A heuristic is developed to determine the optimal ordered date of the used end-of-life product as well as the optimum release dates of new external components. The results reveal that considering some remanufacturing and purchase components costs, the proposed model is more economical in comparison with a model without remanufactured parts. Numerical results are provided to illustrate the impact of the variation of the ordering cost and quality of the used end-of-life product on the system profitability. Finally, the risk due to system repair periods is discussed, which has an impact on managerial decision-making.

  18. A reactor vessel and its internals disassembled and packaged

    International Nuclear Information System (INIS)

    Eisenmann, B.; Prechtl, E.; Suessdorf, W.

    2008-01-01

    2007 was a successful year for the Disassembly Unit of the Karlsruhe Research Center: dismantling the highly activated Karlsruhe Multipurpose Research Reactor (MZFR) was completed successfully and without any incident. A vote of thanks is expressed at this point to all staff members, participating industries and institutions for their extraordinary commitment and their outstanding innovation and work. Preserving and advancing existing knowledge is one of the important pillars securing a sustainable future for generations to come in Germany. Securing and advancing know-how in nuclear technology was defined as a major duty last in late January 2008 by Dr. Peter Fritz, Chairman of the Kerntechnische Gesellschaft e.V. (KTG) and member of the Executive Board of the Karlsruhe Research Center, for instance, in cooperation between the KERNTECHNIK (i.e. nuclear technology) Southwestern Research and Teaching Association and the Karlsruhe Institute of Technology (KIT). The borders of Germany do not constitute a natural radiological barrier, despite the efforts by political groups in this country to convey this impression. This report therefore is to document that the demolition of a nuclear reactor with a high radioactivity inventory can be managed safely. In the light of the experience accumulated with the MZFR, this is feasible only if demolition is carried out immediately instead of the 'problem' of disassembly and conditioning being shifted to future generations. The article is also meant to be a piece of advice by showing the unplannable difficulties which came up, and the technical solutions implemented by the competence team successfully and efficiently. (orig.)

  19. A Taxonomy and Comparison of Haptic Actions for Disassembly Tasks

    National Research Council Canada - National Science Library

    Bloomfield, Aaron; Deng, Yu; Wampler, Jeff; Rondot, Pascale; Harth, Dina; McManus, Mary; Badler, Norman

    2003-01-01

    .... We conducted a series of human subject experiments to compare user performance and preference on a disassembly task with and without haptic feedback using CyberGlove, Phantom, and SpaceMouse interfaces...

  20. Effect of balanced low pressure drying of curcuma longa leaf on skin immune activation activities.

    Science.gov (United States)

    Choi, Wooseok; Lim, Hye Won; Lee, Hyeon Yong

    2014-01-01

    The effect of balanced low pressure drying pretreatment associated with ultrasonication extraction (BU) on the enhancement of skin immune modulatory activities of Curcuma longa leaf was studied by comparing with conventional hot air drying (HE), freeze drying (FE) and balanced low pressure drying (BE) pretreatment processes. In considering skin immune activation activities such as the inhibition of hyaluronidase activity, the BU extract showed ca. 10% higher than those of HE, and even higher than that of the FE extract. Nitric oxide production from macrophage of the BU extract in adding 1.0 mg/mL was increased up to 16.5 μM. When measuring inhibition of IL-6 and TNF-a production from the human T lymphocytes (T cell), the BU extract also showed 53% and 78% of inhibition effect, respectively. It is found that the BU extract could effectively suppress the expression levels of skin inflammation related genes such as Cox-2 and iNOS, down to 80% and 85% compared to the control, respectively. Balanced low pressure drying process was especially active on dehydration of the leaves with minimizing the destruction and making easier elution of the bioactive substances, which resulted in higher extraction yield and better biological activities.

  1. Systems impacts of spent fuel disassembly alternatives

    International Nuclear Information System (INIS)

    1984-07-01

    Three studies were completed to evaluate four alternatives to the disposal of intact spent fuel assemblies in a geologic repository. A preferred spent fuel waste form for disposal was recommended on consideration of (1) package design and fuel/package interaction, (2) long-term, in-repository performance of the waste form, and (3) overall process performance and costs for packaging, handling, and emplacement. The four basic alternative waste forms considered were (1) end fitting removal, (2) fission gas venting, (3) disassembly and close packing, and (4) shearing/immobilization. None of the findings ruled out any alternative on the basis of waste package considerations or long-term performance of the waste form. The third alternative offers flexibility in loading that may prove attractive in the various geologic media under consideration, greatly reduces the number of packages, and has the lowest unit cost. These studies were completed in October, 1981. Since then Westinghouse Electric Corporation and the Office of Nuclear Waste Isolation have completed studies in related fields. This report is now being published to provide publicly the background material that is contained within. 47 references, 28 figures, 31 tables

  2. Shaping tissues by balancing active forces and geometric constraints

    Science.gov (United States)

    Foolen, Jasper; Yamashita, Tadahiro; Kollmannsberger, Philip

    2016-02-01

    The self-organization of cells into complex tissues during growth and regeneration is a combination of physical-mechanical events and biochemical signal processing. Cells actively generate forces at all stages in this process, and according to the laws of mechanics, these forces result in stress fields defined by the geometric boundary conditions of the cell and tissue. The unique ability of cells to translate such force patterns into biochemical information and vice versa sets biological tissues apart from any other material. In this topical review, we summarize the current knowledge and open questions of how forces and geometry act together on scales from the single cell to tissues and organisms, and how their interaction determines biological shape and structure. Starting with a planar surface as the simplest type of geometric constraint, we review literature on how forces during cell spreading and adhesion together with geometric constraints impact cell shape, stress patterns, and the resulting biological response. We then move on to include cell-cell interactions and the role of forces in monolayers and in collective cell migration, and introduce curvature at the transition from flat cell sheets to three-dimensional (3D) tissues. Fibrous 3D environments, as cells experience them in the body, introduce new mechanical boundary conditions and change cell behaviour compared to flat surfaces. Starting from early work on force transmission and collagen remodelling, we discuss recent discoveries on the interaction with geometric constraints and the resulting structure formation and network organization in 3D. Recent literature on two physiological scenarios—embryonic development and bone—is reviewed to demonstrate the role of the force-geometry balance in living organisms. Furthermore, the role of mechanics in pathological scenarios such as cancer is discussed. We conclude by highlighting common physical principles guiding cell mechanics, tissue patterning and

  3. Shaping tissues by balancing active forces and geometric constraints

    International Nuclear Information System (INIS)

    Foolen, Jasper; Yamashita, Tadahiro; Kollmannsberger, Philip

    2016-01-01

    The self-organization of cells into complex tissues during growth and regeneration is a combination of physical–mechanical events and biochemical signal processing. Cells actively generate forces at all stages in this process, and according to the laws of mechanics, these forces result in stress fields defined by the geometric boundary conditions of the cell and tissue. The unique ability of cells to translate such force patterns into biochemical information and vice versa sets biological tissues apart from any other material. In this topical review, we summarize the current knowledge and open questions of how forces and geometry act together on scales from the single cell to tissues and organisms, and how their interaction determines biological shape and structure. Starting with a planar surface as the simplest type of geometric constraint, we review literature on how forces during cell spreading and adhesion together with geometric constraints impact cell shape, stress patterns, and the resulting biological response. We then move on to include cell–cell interactions and the role of forces in monolayers and in collective cell migration, and introduce curvature at the transition from flat cell sheets to three-dimensional (3D) tissues. Fibrous 3D environments, as cells experience them in the body, introduce new mechanical boundary conditions and change cell behaviour compared to flat surfaces. Starting from early work on force transmission and collagen remodelling, we discuss recent discoveries on the interaction with geometric constraints and the resulting structure formation and network organization in 3D. Recent literature on two physiological scenarios—embryonic development and bone—is reviewed to demonstrate the role of the force-geometry balance in living organisms. Furthermore, the role of mechanics in pathological scenarios such as cancer is discussed. We conclude by highlighting common physical principles guiding cell mechanics, tissue patterning

  4. The Relationship Between Pedometer-Determined Ambulatory Activity and Balance Variables Within an Older Adult Population

    OpenAIRE

    Campbell, Candice; Kress, Jeff; Schroeder, Jan; Donlin, Ayla; Rozenek, Ralph

    2016-01-01

    The purpose of this investigation was to determine the differences between gender, physical activity level, and balance in an older adult population. A secondary purpose was to examine the relationship between pedometer-determined ambulatory activity and balance. Forty-six older adults aged 73.7 ± 6.2 years participated in the study. Participants completed the Fullerton Advanced Balance (FAB) Scale and completed a 2-week daily step recording to determine average steps taken per day. Low-level...

  5. Early cysteine-dependent inactivation of 26S proteasomes does not involve particle disassembly

    Directory of Open Access Journals (Sweden)

    Martín Hugo

    2018-06-01

    Full Text Available Under oxidative stress 26S proteasomes suffer reversible disassembly into its 20S and 19S subunits, a process mediated by HSP70. This inhibits the degradation of polyubiquitinated proteins by the 26S proteasome and allows the degradation of oxidized proteins by a free 20S proteasome. Low fluxes of antimycin A-stimulated ROS production caused dimerization of mitochondrial peroxiredoxin 3 and cytosolic peroxiredoxin 2, but not peroxiredoxin overoxidation and overall oxidation of cellular protein thiols. This moderate redox imbalance was sufficient to inhibit the ATP stimulation of 26S proteasome activity. This process was dependent on reversible cysteine oxidation. Moreover, our results show that this early inhibition of ATP stimulation occurs previous to particle disassembly, indicating an intermediate step during the redox regulation of the 26S proteasome with special relevance under redox signaling rather than oxidative stress conditions.

  6. Assisting People with Disabilities to Actively Improve Their Collaborative Physical Activities with Nintendo Wii Balance Boards by Controlling Environmental Stimulation

    Science.gov (United States)

    Shih, Ching-Hsiang; Chen, Ling-Che; Shih, Ching-Tien

    2012-01-01

    The latest researches have adopted software technology to modify the Nintendo Wii Balance Board functionality and used it to enable two people with developmental disabilities to actively perform physical activities. This study extended the latest research of the Wii Balance Board application to assess whether four people (two groups) with…

  7. The dose-response relationship of balance training in physically active older adults.

    Science.gov (United States)

    Maughan, Kristen K; Lowry, Kristin A; Franke, Warren D; Smiley-Oyen, Ann L

    2012-10-01

    A 6-wk group balance-training program was conducted with physically active older adults (based on American College of Sports Medicine requirements) to investigate the effect of dose-related static and dynamic balance-specific training. All participants, age 60-87 yr, continued their regular exercise program while adding balance training in 1 of 3 doses: three 20-min sessions/wk (n = 20), one 20-min session/wk (n = 21), or no balance training (n = 19). Static balance (single-leg-stance, tandem), dynamic balance (alternate stepping, limits of stability), and balance confidence (ABC) were assessed pre- and posttraining. Significant interactions were observed for time in single-leg stance, excursion in limits of stability, and balance confidence, with the greatest increase observed in the group that completed 3 training sessions/wk. The results demonstrate a dose-response relationship indicating that those who are already physically active can improve balance performance with the addition of balance-specific training.

  8. A symbolic methodology to improve disassembly process design.

    Science.gov (United States)

    Rios, Pedro; Blyler, Leslie; Tieman, Lisa; Stuart, Julie Ann; Grant, Ed

    2003-12-01

    Millions of end-of-life electronic components are retired annually due to the proliferation of new models and their rapid obsolescence. The recovery of resources such as plastics from these goods requires their disassembly. The time required for each disassembly and its associated cost is defined by the operator's familiarity with the product design and its complexity. Since model proliferation serves to complicate an operator's learning curve, it is worthwhile to investigate the benefits to be gained in a disassembly operator's preplanning process. Effective disassembly process design demands the application of green engineering principles, such as those developed by Anastas and Zimmerman (Environ. Sci. Technol. 2003, 37, 94A-101A), which include regard for product complexity, structural commonality, separation energy, material value, and waste prevention. This paper introduces the concept of design symbolsto help the operator more efficiently survey product complexity with respect to location and number of fasteners to remove a structure that is common to all electronics: the housing. With a sample of 71 different computers, printers, and monitors, we demonstrate that appropriate symbols reduce the total disassembly planning time by 13.2 min. Such an improvement could well make efficient the separation of plastic that would otherwise be destined for waste-to-energy or landfill. The symbolic methodology presented may also improve Design for Recycling and Design for Maintenance and Support.

  9. Decommissioning of nuclear facilities: Decontamination, disassembly and waste management

    International Nuclear Information System (INIS)

    1983-01-01

    The term 'decommissioning', as used within the nuclear industry, means the actions taken at the end of a facility's useful life to retire the facility from service in a manner that provides adequate protection for the health and safety of the decommissioning workers, the general public, and for the environment. These actions can range from merely closing down the facility and a minimal removal of radioactive material coupled with continuing maintenance and surveillance, to a complete removal of residual radioactivity in excess of levels acceptable for unrestricted use of the facility and its site. This latter condition, unrestricted use, is the ultimate goal of all decommissioning actions at retired nuclear facilities. The purpose of this report is to provide an information base on the considerations important to decommissioning, the methods available for decontamination and disassembly of a nuclear facility, the management of the resulting radioactive wastes, and the areas of decommissioning methodology where improvements might be made. Specific sections are devoted to each of these topics, and conclusions are presented concerning the present status of each topic. A summary of past decommissioning experience in Member States is presented in the Appendix. The report, with its discussions of necessary considerations, available operational methods, and waste management practices, together with supporting references, provides an appreciation of the activities that comprise decommissioning of nuclear facilities. It is anticipated that the information presented in the report should prove useful to persons concerned with the development of plans for the decommissioning of retired nuclear facilities

  10. A balance of activity in brain control and reward systems predicts self-regulatory outcomes

    OpenAIRE

    Lopez, Richard B.; Chen, Pin-Hao A.; Huckins, Jeremy F.; Hofmann, Wilhelm; Kelley, William M.; Heatherton, Todd F.

    2017-01-01

    Abstract Previous neuroimaging work has shown that increased reward-related activity following exposure to food cues is predictive of self-control failure. The balance model suggests that self-regulation failures result from an imbalance in reward and executive control mechanisms. However, an open question is whether the relative balance of activity in brain systems associated with executive control (vs reward) supports self-regulatory outcomes when people encounter tempting cues in daily lif...

  11. AGR-2 Irradiated Test Train Preliminary Inspection and Disassembly First Look

    Energy Technology Data Exchange (ETDEWEB)

    Ploger, Scott [Idaho National Lab. (INL), Idaho Falls, ID (United States); Demkowciz, Paul [Idaho National Lab. (INL), Idaho Falls, ID (United States); Harp, Jason [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-05-01

    The AGR 2 irradiation experiment began in June 2010 and was completed in October 2013. The test train was shipped to the Materials and Fuels Complex in July 2014 for post-irradiation examination (PIE). The first PIE activities included nondestructive examination of the test train, followed by disassembly of the test train and individual capsules and detailed inspection of the capsule contents, including the fuel compacts and their graphite fuel holders. Dimensional metrology was then performed on the compacts, graphite holders, and steel capsule shells. AGR 2 disassembly and metrology were performed with the same equipment used successfully on AGR 1 test train components. Gamma spectrometry of the intact test train gave a preliminary look at the condition of the interior components. No evidence of damage to compacts or graphite components was evident from the isotopic and gross gamma scans. Disassembly of the AGR 2 test train and its capsules was conducted rapidly and efficiently by employing techniques refined during the AGR 1 disassembly campaign. Only one major difficulty was encountered while separating the test train into capsules when thermocouples (of larger diameter than used in AGR 1) and gas lines jammed inside the through tubes of the upper capsules, which required new tooling for extraction. Disassembly of individual capsules was straightforward with only a few minor complications. On the whole, AGR 2 capsule structural components appeared less embrittled than their AGR 1 counterparts. Compacts from AGR 2 Capsules 2, 3, 5, and 6 were in very good condition upon removal. Only relatively minor damage or markings were visible using high resolution photographic inspection. Compact dimensional measurements indicated radial shrinkage between 0.8 to 1.7%, with the greatest shrinkage observed on Capsule 2 compacts that were irradiated at higher temperature. Length shrinkage ranged from 0.1 to 0.9%, with by far the lowest axial shrinkage on Capsule 3 compacts

  12. SAVANNAH RIVER SITE R-REACTOR DISASSEMBLY BASIN IN-SITU DECOMMISSIONING -10499

    Energy Technology Data Exchange (ETDEWEB)

    Langton, C.; Serrato, M.; Blankenship, J.; Griffin, W.

    2010-01-04

    The US DOE concept for facility in-situ decommissioning (ISD) is to physically stabilize and isolate intact, structurally sound facilities that are no longer needed for their original purpose, i.e., generating (reactor facilities), processing(isotope separation facilities) or storing radioactive materials. The 105-R Disassembly Basin is the first SRS reactor facility to undergo the in-situ decommissioning (ISD) process. This ISD process complies with the 105-R Disassembly Basin project strategy as outlined in the Engineering Evaluation/Cost Analysis for the Grouting of the R-Reactor Disassembly Basin at the Savannah River Site and includes: (1) Managing residual water by solidification in-place or evaporation at another facility; (2) Filling the below grade portion of the basin with cementitious materials to physically stabilize the basin and prevent collapse of the final cap - Sludge and debris in the bottom few feet of the basin will be encapsulated between the basin floor and overlying fill material to isolate it from the environment; (3) Demolishing the above grade portion of the structure and relocating the resulting debris to another location or disposing of the debris in-place; and (4) Capping the basin area with a concrete slab which is part of an engineered cap to prevent inadvertent intrusion. The estimated total grout volume to fill the 105-R Reactor Disassembly Basin is 24,384 cubic meters or 31,894 cubic yards. Portland cement-based structural fill materials were designed and tested for the reactor ISD project, and a placement strategy for stabilizing the basin was developed. Based on structural engineering analyses and material flow considerations, maximum lift heights and differential height requirements were determined. Pertinent data and information related to the SRS 105-R Reactor Disassembly Basin in-situ decommissioning include: regulatory documentation, residual water management, area preparation activities, technology needs, fill material

  13. Mathematical and Simulation Modelling of Moisture Diffusion Mechanism during Plastic IC Packages Disassembly

    OpenAIRE

    Peng Mou; Dong Xiang; Guanghong Duan

    2013-01-01

    Reuse of plastic IC packages disassembled from printed circuit boards (PCBs) has significant environmental benefits and economic value. The interface delamination caused by moisture diffusion is the main failure mode of IC packages during the disassembling process, which greatly reduces the reusability and reliability of disassembled IC packages. Exploring moisture diffusion mechanism is a prerequisite to optimize prebaking processes before disassembling that is an effective way to avoid the ...

  14. Desmosome Assembly and Disassembly Are Membrane Raft-Dependent

    Science.gov (United States)

    Faundez, Victor; Koval, Michael; Mattheyses, Alexa L.; Kowalczyk, Andrew P.

    2014-01-01

    Strong intercellular adhesion is critical for tissues that experience mechanical stress, such as the skin and heart. Desmosomes provide adhesive strength to tissues by anchoring desmosomal cadherins of neighboring cells to the intermediate filament cytoskeleton. Alterations in assembly and disassembly compromise desmosome function and may contribute to human diseases, such as the autoimmune skin blistering disease pemphigus vulgaris (PV). We previously demonstrated that PV auto-antibodies directed against the desmosomal cadherin desmoglein 3 (Dsg3) cause loss of adhesion by triggering membrane raft-mediated Dsg3 endocytosis. We hypothesized that raft membrane microdomains play a broader role in desmosome homeostasis by regulating the dynamics of desmosome assembly and disassembly. In human keratinocytes, Dsg3 is raft associated as determined by biochemical and super resolution immunofluorescence microscopy methods. Cholesterol depletion, which disrupts rafts, prevented desmosome assembly and adhesion, thus functionally linking rafts to desmosome formation. Interestingly, Dsg3 did not associate with rafts in cells lacking desmosomal proteins. Additionally, PV IgG-induced desmosome disassembly occurred by redistribution of Dsg3 into raft-containing endocytic membrane domains, resulting in cholesterol-dependent loss of adhesion. These findings demonstrate that membrane rafts are required for desmosome assembly and disassembly dynamics, suggesting therapeutic potential for raft targeting agents in desmosomal diseases such as PV. PMID:24498201

  15. Environmental influences on food choice, physical activity and energy balance.

    Science.gov (United States)

    Popkin, Barry M; Duffey, Kiyah; Gordon-Larsen, Penny

    2005-12-15

    In this paper, the environment is defined as the macro- and community-level factors, including physical, legal and policy factors, that influence household and individual decisions. Thus, environment is conceived as the external context in which household and individual decisions are made. This paper reviews the literature on the ways the environment affects diet, physical activity, and obesity. Other key environmental factors discussed include economic, legal, and policy factors. Behind the major changes in diet and physical activity in the US and globally lie large shifts in food production, processing, and distribution systems as well as food shopping and eating options, resulting in the increase in availability of energy-dense foods. Similarly, the ways we move at home, work, leisure, and travel have shifted markedly, resulting in substantial reductions in energy expenditure. Many small area studies have linked environmental shifts with diet and activity changes. This paper begins with a review of environmental influences on diet and physical activity, and includes the discussion of two case studies on environmental influences on physical activity in a nationally representative sample of US adolescents. The case studies illustrate the important role of physical activity resources and the inequitable distribution of such activity-related facilities and resources, with high minority, low educated populations at strong disadvantage. Further, the research shows a significant association of such facilities with individual-level health behavior. The inequity in environmental supports for physical activity may underlie health disparities in the US population.

  16. Lifestyle: importance of a balanced diet and physical activity.

    Science.gov (United States)

    Shewmake, Roger A

    2015-01-01

    The goal of this article is to provide evidenced-based information to help the clinician understand the relationship of lifestyle (nutritional and activity) approaches to disease prevention and health promotion. Major health factors correlated to these activities of daily life will be reviewed.

  17. State-of-Charge Estimation and Active Cell Pack Balancing Design of Lithium Battery Power System for Smart Electric Vehicle

    OpenAIRE

    Gao, Z. C.; Chin, C. S.; Toh, W. D.; Chiew, J.; Jia, J.

    2017-01-01

    This paper presents an integrated state-of-charge (SOC) estimation model and active cell balancing of a 12-cell lithium iron phosphate (LiFePO4) battery power system. The strong tracking cubature extended Kalman filter (STCEKF) gave an accurate SOC prediction compared to other Kalman-based filter algorithms. The proposed groupwise balancing of the multiple SOC exhibited a higher balancing speed and lower balancing loss than other cell balancing designs. The experimental results demonstrated t...

  18. Multi-kanban mechanism for personal computer disassembly

    Science.gov (United States)

    Udomsawat, Gun; Gupta, Surendra M.; Kamarthi, Sagar V.

    2004-12-01

    The use of personal computers (PCs) continues to increase every year. According to a 1999 figure, 50 percent of all US households owned PCs, a figure that continues to rise every year. With continuous development of sophisticated software, PCs are becoming increasingly powerful. In addition, the price of a PC continues to steadily decline. Furthermore, the typical life of a PC in the workplace is approximately two to three years while in the home it is three to five years. As these PCs become obsolete, they are replaced and the old PCs are disposed of. It is estimated that between 14 and 20 million PCs are retired annually in the US. While 20 to 30% of the units may be resold, the others are discarded. These discards represent a significant potential source of lead for the waste stream. In some communities, waste cathode ray tubes (CRTs) represent the second largest source of lead in the waste stream after vehicular lead acid batteries. PCs are, therefore, not suitable for dumping in landfills. Besides, several components of a PC can be reused and then there are other valuable materials that can also be harvested. And with the advent of product stewardship, product recovery is the best solution for manufacturers. Disassembly line is perhaps the most suitable set up for disassembling PCs. However, planning and scheduling of disassembly on a disassembly line is complicated. In this paper, we discuss some of the complications including product arrival, demand arrival, inventory fluctuation and production control mechanisms. We then show how to overcome them by implementing a multi-kanban mechanism in the PC disassembly line setting. The multi-kanban mechanism relies on dynamic routing of kanbans according to the state of the system. We investigate the multi-kanban mechanism using simulation and demonstrate that this mechanism is superior to the traditional push system in terms of controlling the system"s inventory while maintaining a decent customer service level.

  19. Muscle activation timing and balance response in chronic lower back pain patients with associated radiculopathy.

    Science.gov (United States)

    Frost, Lydia R; Brown, Stephen H M

    2016-02-01

    Patients with chronic low back pain and associated radiculopathy present with neuromuscular symptoms both in their lower back and down their leg; however, investigations of muscle activation have so far been isolated to the lower back. During balance perturbations, it is necessary that lower limb muscles activate with proper timing and sequencing along with the lower back musculature to efficiently regain balance control. Patients with chronic low back pain and radiculopathy and matched controls completed a series of balance perturbations (rapid bilateral arm raise, unanticipated and anticipated sudden loading, and rapid rise to toe). Muscle activation timing and sequencing as well as kinetic response to the perturbations were analyzed. Patients had significantly delayed lower limb muscle activation in rapid arm raise trials as compared to controls. In sudden loading trials, muscle activation timing was not delayed in patients; however, some differences in posterior chain muscle activation sequencing were present. Patients demonstrated less anterior-posterior movement in unanticipated sudden loading trials, and greater medial-lateral movement in rise to toe trials. Patients with low back pain and radiculopathy demonstrated some significant differences from control participants in terms of muscle activation timing, sequencing, and overall balance control. The presence of differences between patients and controls, specifically in the lower limb, indicates that radiculopathy may play a role in altering balance control in these patients. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. The Relationship Between Pedometer-Determined Ambulatory Activity and Balance Variables Within an Older Adult Population.

    Science.gov (United States)

    Campbell, Candice; Kress, Jeff; Schroeder, Jan; Donlin, Ayla; Rozenek, Ralph

    2016-01-01

    The purpose of this investigation was to determine the differences between gender, physical activity level, and balance in an older adult population. A secondary purpose was to examine the relationship between pedometer-determined ambulatory activity and balance. Forty-six older adults aged 73.7 ± 6.2 years participated in the study. Participants completed the Fullerton Advanced Balance (FAB) Scale and completed a 2-week daily step recording to determine average steps taken per day. Low-level activity participants (7,500 steps/day) in weight, age, and the number of medications reported. Males performed better than females on the two-footed jump test and reactive postural test FAB assessments. High-level activity participants performed significantly better than low-level activity participants on all FAB assessments except stand with feet together and eyes closed, reach forward to object, and walk with head turns.

  1. The Relationship Between Pedometer-Determined Ambulatory Activity and Balance Variables Within an Older Adult Population

    Directory of Open Access Journals (Sweden)

    Candice Campbell MS

    2016-12-01

    Full Text Available The purpose of this investigation was to determine the differences between gender, physical activity level, and balance in an older adult population. A secondary purpose was to examine the relationship between pedometer-determined ambulatory activity and balance. Forty-six older adults aged 73.7 ± 6.2 years participated in the study. Participants completed the Fullerton Advanced Balance (FAB Scale and completed a 2-week daily step recording to determine average steps taken per day. Low-level activity participants (7,500 steps/day in weight, age, and the number of medications reported. Males performed better than females on the two-footed jump test and reactive postural test FAB assessments. High-level activity participants performed significantly better than low-level activity participants on all FAB assessments except stand with feet together and eyes closed, reach forward to object, and walk with head turns.

  2. Towards a new paradigm: Activity level balanced sustainability reporting.

    Science.gov (United States)

    Samudhram, Ananda; Siew, Eu-Gene; Sinnakkannu, Jothee; Yeow, Paul H P

    2016-11-01

    Technoeconomic paradigms based economic growth theories suggest that waves of technological innovations drove the economic growth of advanced economies. Widespread economic degradation and pollution is an unintended consequence of such growth. Tackling environmental and social issues at firm levels would help us to overcome such issues at macro-levels. Consequently, the Triple Bottom Line (TBL) reporting approach promotes firm level economic, environmental and social performances. Incorporating Zink's (2014) 3-pillar presentation model, this paper indicates that economic, social and environmental performances tend to be reported at firm level. All three pillars are not covered evenly at the activity levels. Thus, a loophole is identified whereby excellent environmental performance at activity levels could potentially leave poor social performance undisclosed. A refinement of the TBL paradigm, whereby all three pillars are covered at the activity level, is suggested, to enhance sustainability reporting. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Balance of individuals at different age involved in physical activity – review of publications

    Directory of Open Access Journals (Sweden)

    Angelika Winiarska

    2017-07-01

    Full Text Available Balance is what we call the ability to control the center of gravity over the support plane in a given environment (also defined as the ability to maintain a vertical position of the body without the help of another person and the ability of regaining  balance during and after motion. Not only is inner ear responsible for mandating balance but also proprioceptors, cerebellum,  properly functioning nervous system and well-trained movement organs or efficient effector.  Postural control also is also affected by genetic conditions and primitive reactive strategies. Included to them are ankle strategy, that is restoring the center of gravity only by movements of the hocks, the hip strategy which is restoring the center of gravity by violent hip movements and step-by-step strategy in which making a step is required to restore the center of gravity. The balance system is quite complex. Damage to even on of the element of this system causes postural instability. In the case of disturbance of balance system , it can be indirectly influenced by nervous system through feedback, priming motion and motor control learning. Improved balance can be achieved with equivalent training. The aim of the study was to analyze different authors’ research on athlete balance. Five selected research articles on athletes have been analyzed. The authors have demonstrated a high level of effectiveness in balance training in the process of developing and improving the sense of balance. Individuals who have been in the past or are physically active now retain a better body balance.

  4. Connexin43 hemichannels contributes to the disassembly of cell junctions through modulation of intracellular oxidative status

    Directory of Open Access Journals (Sweden)

    Yuan Chi

    2016-10-01

    Full Text Available Connexin (Cx hemichannels regulate many cellular processes with little information available regarding their mechanisms. Given that many pathological factors that activate hemichannels also disrupts the integrity of cellular junctions, we speculated a potential participation of hemichannels in the regulation of cell junctions. Here we tested this hypothesis. Exposure of renal tubular epithelial cells to Ca2+-free medium led to disassembly of tight and adherens junctions, as indicated by the reduced level of ZO-1 and cadherin, disorganization of F-actin, and severe drop in transepithelial electric resistance. These changes were preceded by an activation of Cx43 hemichannels, as revealed by extracellular efflux of ATP and intracellular influx of Lucifer Yellow. Inhibition of hemichannels with chemical inhibitors or Cx43 siRNA greatly attenuated the disassembly of cell junctions. Further analysis using fetal fibroblasts derived from Cx43 wide-type (Cx43+/+, heterozygous (Cx43+/- and knockout (Cx43-/- littermates showed that Cx43-positive cells (Cx43+/+ exhibited more dramatic changes in cell shape, F-actin, and cadherin in response to Ca2+ depletion, as compared to Cx43-null cells (Cx43-/-. Consistently, these cells had higher level of protein carbonyl modification and phosphorylation, and much stronger activation of P38 and JNK. Hemichannel opening led to extracellular loss of the major antioxidant glutathione (GSH. Supplement of cells with exogenous GSH or inhibition of oxidative sensitive kinases largely prevented the above-mentioned changes. Taken together, our study indicates that Cx43 hemichannels promote the disassembly of cell junctions through regulation of intracellular oxidative status.

  5. Effects of flow balancing on active magnetic regenerator performance

    DEFF Research Database (Denmark)

    Eriksen, Dan; Engelbrecht, Kurt; Bahl, Christian

    2016-01-01

    Experiments with a recently constructed rotary multi-bed active magnetic regnenerator (AMR) prototype have revealed strong impacts on the temperature span from variations in the resistances of the flow channels carrying heat transfer fluid in and out of the regenerator beds. In this paper we show...

  6. Shaping tissues by balancing active forces and geometric constraints

    NARCIS (Netherlands)

    Foolen, J.; Yamashi, T.; Kollmannsberger, P.

    2015-01-01

    The self-organization of cells into complex tissues during growth and regeneration is a combination of physical–mechanical events and biochemical signal processing. Cells actively generate forces at all stages in this process, and according to the laws of mechanics, these forces result in stress

  7. Balance Training Reduces Brain Activity during Motor Simulation of a Challenging Balance Task in Older Adults: An fMRI Study.

    Science.gov (United States)

    Ruffieux, Jan; Mouthon, Audrey; Keller, Martin; Mouthon, Michaël; Annoni, Jean-Marie; Taube, Wolfgang

    2018-01-01

    Aging is associated with a shift from an automatic to a more cortical postural control strategy, which goes along with deteriorations in postural stability. Although balance training has been shown to effectively counteract these behavioral deteriorations, little is known about the effect of balance training on brain activity during postural tasks in older adults. We, therefore, assessed postural stability and brain activity using fMRI during motor imagery alone (MI) and in combination with action observation (AO; i.e., AO+MI) of a challenging balance task in older adults before and after 5 weeks of balance training. Results showed a nonsignificant trend toward improvements in postural stability after balance training, accompanied by reductions in brain activity during AO+MI of the balance task in areas relevant for postural control, which have been shown to be over-activated in older adults during (simulation of) motor performance, including motor, premotor, and multisensory vestibular areas. This suggests that balance training may reverse the age-related cortical over-activations and lead to changes in the control of upright posture toward the one observed in young adults.

  8. Unified Balance Scale: an activity-based, bed to community, and aetiology-independent measure of balance calibrated with Rasch analysis.

    Science.gov (United States)

    La Porta, Fabio; Franceschini, Marco; Caselli, Serena; Cavallini, Paola; Susassi, Sonia; Tennant, Alan

    2011-04-01

    To build a new activity-based, "bed to community", aetiology-independent measure of balance within the neurological rehabilitation setting by merging some existing scales. Balance scales were selected using a conceptual framework and subsequently administered to a convenience sample of adult patients with balance problems due to different neurological aetiologies. Data were then processed using classical psychometric analyses and Rasch analysis in order to construct a new balance measurement tool. The Berg Balance Scale, the Tinetti Scales and the Fullerton Advanced Balance Scale were selected and administered to a sample of patients, giving 302 observations. Classical psychometric analyses (item and scale analysis; confirmatory factor analysis) were undertaken on the pooled 40-item set with confirmation of unidimensionality. The subsequent Rasch analysis allowed the identification of a 27-item set satisfying the Rasch Model's requirements for fundamental measurement, with further confirmation of unidimensionality by post-hoc confirmatory factor analysis. The new scale (Unified Balance Scale) holds proven measurement properties and may be a candidate tool for "bed to community" balance measurement for patients with balance problems within the neuro-rehabilitation setting. Future studies are warranted to explore further its external validity and other clinical properties, as well as to improve its usability.

  9. The United States pit disassembly and conversion project -- Meeting the MOX fuel specification

    International Nuclear Information System (INIS)

    Nelson, T.O.; James, C.A.; Kolman, D.G.

    1998-01-01

    The US is actively involved in demonstrating the disassembly of nuclear weapons pits to an unclassified form readied for disposition. The MOX option is the most likely path forward for plutonium that originated from nuclear weapon pits. The US demonstration line for pit disassembly and conversion is known as ARIES, the advanced recovery and integrated extraction system. The ARIES demonstration line is being used to gather data in an integrated fashion of the technologies needed for pit disassembly and conversion. These activities include the following modules: pit bisection, hydride-dehydride, oxide conversion, canning, electrolytic decontamination, and nondestructive assay (NDA). Pit bisection swages in a pit in half. Hydride-dehydride converts the pit plutonium metal to an unclassified metal button. To convert the plutonium metal to an oxide the US is investigating a number of options. The primary oxide conversion approach involves variations of combining plutonium hydriding and subsequent oxidation. Another approach is to simply oxidize the metal under controlled conditions-direct metal oxidation (DMO). To remove the gallium from the plutonium oxide, a thermal distillation approach is being used. These pyrochemical approaches will substantially reduce the wastes produced for oxide conversion of weapon plutonium, compared to traditional aqueous processing. The packaging of either the plutonium metal or oxide to long term storage criteria involves the canning and electrolytic decontamination modules. The NDA suite of instruments is then used to assay the material in the containers, which enables international verification without the need to open the containers and repackage them. All of these processes are described

  10. Actin-interacting Protein 1 Promotes Disassembly of Actin-depolymerizing Factor/Cofilin-bound Actin Filaments in a pH-dependent Manner.

    Science.gov (United States)

    Nomura, Kazumi; Hayakawa, Kimihide; Tatsumi, Hitoshi; Ono, Shoichiro

    2016-03-04

    Actin-interacting protein 1 (AIP1) is a conserved WD repeat protein that promotes disassembly of actin filaments when actin-depolymerizing factor (ADF)/cofilin is present. Although AIP1 is known to be essential for a number of cellular events involving dynamic rearrangement of the actin cytoskeleton, the regulatory mechanism of the function of AIP1 is unknown. In this study, we report that two AIP1 isoforms from the nematode Caenorhabditis elegans, known as UNC-78 and AIPL-1, are pH-sensitive in enhancement of actin filament disassembly. Both AIP1 isoforms only weakly enhance disassembly of ADF/cofilin-bound actin filaments at an acidic pH but show stronger disassembly activity at neutral and basic pH values. However, a severing-defective mutant of UNC-78 shows pH-insensitive binding to ADF/cofilin-decorated actin filaments, suggesting that the process of filament severing or disassembly, but not filament binding, is pH-dependent. His-60 of AIP1 is located near the predicted binding surface for the ADF/cofilin-actin complex, and an H60K mutation of AIP1 partially impairs its pH sensitivity, suggesting that His-60 is involved in the pH sensor for AIP1. These biochemical results suggest that pH-dependent changes in AIP1 activity might be a novel regulatory mechanism of actin filament dynamics. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  11. The effect of musical movement activities on the balance function of autistic children

    Directory of Open Access Journals (Sweden)

    Atoosa Atigh

    2013-11-01

    Full Text Available Background: Autistic children with low level performance have problems in social interaction, communication skills and sensory processing as well as motor and balance function. Musical activity is one of the most effective therapeutic strategies to manage some of these core defects. The present study examined the effect of musical movement activities on the balance function of 7 to 14 years autistic children with low performance. Methods: Twenty-two autistic students with low performance at age range of 7 to 14 years old participated in the study were assigned to experimental and control group randomly. The interventions were consisted of musical movement activities for experimental and without music for control group. Balance performance of subjects was assessed before treatment, and after 12th and 24th therapeutic sessions using balancing subtest of Bruininks-Oseretsky test of motor proficiency (BOTMP. The assessments were double blinded. Data were analyzed employing repeated measures of ANOVA. The SPSS software-version 17was used. Results: The results indicated that the effect of interventions on two groups was significantly different (F; 1.2= 52.8, P<0.001. The improvement in the balancing performance has been observed in both groups after 12th and 24th sessions although the difference in balance scores between groups was higher after 24th treatment session (P<0.001; that is in experimental group more improvement was obtained. Conclusion: The findings suggest that musical movement activities can accelerate the improvement in balance function of autistic children with low performance.

  12. The use of a running wheel to measure activity in rodents: Relationship to energy balance, general activity, and reward

    Science.gov (United States)

    Levine, James A.

    2015-01-01

    Running wheels are commonly employed to measure rodent physical activity in a variety of contexts, including studies of energy balance and obesity. There is no consensus on the nature of wheel-running activity or its underlying causes, however. Here, we will begin by systematically reviewing how running wheel availability affects physical activity and other aspects of energy balance in laboratory rodents. While wheel running and physical activity in the absence of a wheel commonly correlate in a general sense, in many specific aspects the two do not correspond. In fact, the presence of running wheels alters several aspects of energy balance, including body weight and composition, food intake, and energy expenditure of activity. We contend that wheel-running activity should be considered a behavior in and of itself, reflecting several underlying behavioral processes in addition to a rodent's general, spontaneous activity. These behavioral processes include defensive behavior, predatory aggression, and depression- and anxiety-like behaviors. As it relates to energy balance, wheel running engages several brain systems—including those related to the stress response, mood, and reward, and those responsive to growth factors—that influence energy balance indirectly. We contend that wheel-running behavior represents factors in addition to rodents' tendency to be physically active, engaging additional neural and physiological mechanisms which can then independently alter energy balance and behavior. Given the impact of wheel-running behavior on numerous overlapping systems that influence behavior and physiology, this review outlines the need for careful design and interpretation of studies that utilize running wheels as a means for exercise or as a measurement of general physical activity. PMID:22230703

  13. The use of a running wheel to measure activity in rodents: relationship to energy balance, general activity, and reward.

    Science.gov (United States)

    Novak, Colleen M; Burghardt, Paul R; Levine, James A

    2012-03-01

    Running wheels are commonly employed to measure rodent physical activity in a variety of contexts, including studies of energy balance and obesity. There is no consensus on the nature of wheel-running activity or its underlying causes, however. Here, we will begin by systematically reviewing how running wheel availability affects physical activity and other aspects of energy balance in laboratory rodents. While wheel running and physical activity in the absence of a wheel commonly correlate in a general sense, in many specific aspects the two do not correspond. In fact, the presence of running wheels alters several aspects of energy balance, including body weight and composition, food intake, and energy expenditure of activity. We contend that wheel-running activity should be considered a behavior in and of itself, reflecting several underlying behavioral processes in addition to a rodent's general, spontaneous activity. These behavioral processes include defensive behavior, predatory aggression, and depression- and anxiety-like behaviors. As it relates to energy balance, wheel running engages several brain systems-including those related to the stress response, mood, and reward, and those responsive to growth factors-that influence energy balance indirectly. We contend that wheel-running behavior represents factors in addition to rodents' tendency to be physically active, engaging additional neural and physiological mechanisms which can then independently alter energy balance and behavior. Given the impact of wheel-running behavior on numerous overlapping systems that influence behavior and physiology, this review outlines the need for careful design and interpretation of studies that utilize running wheels as a means for exercise or as a measurement of general physical activity. Copyright © 2012 Elsevier Ltd. All rights reserved.

  14. Preliminary topical report on comparison reactor disassembly calculations

    International Nuclear Information System (INIS)

    McLaughlin, T.P.

    1975-11-01

    Preliminary results of comparison disassembly calculations for a representative LMFBR model (2100-l voided core) and arbitrary accident conditions are described. The analytical methods employed were the computer programs: FX2-POOL, PAD, and VENUS-II. The calculated fission energy depositions are in good agreement, as are measures of the destructive potential of the excursions, kinetic energy, and work. However, in some cases the resulting fuel temperatures are substantially divergent. Differences in the fission energy deposition appear to be attributable to residual inconsistencies in specifying the comparison cases. In contrast, temperature discrepancies probably stem from basic differences in the energy partition models inherent in the codes. Although explanations of the discrepancies are being pursued, the preliminary results indicate that all three computational methods provide a consistent, global characterization of the contrived disassembly accident

  15. Integrating Safeguards into the Pit Disassembly and Conversion Facility

    International Nuclear Information System (INIS)

    Clark, T.G.

    2002-01-01

    In September 2000, the United States and the Russian Federation entered into an agreement which stipulates each country will irreversibly transform 34 metric tons of weapons-grade plutonium into material which could not be used for weapon purposes. Supporting the Department of Energy's (DOE) program to dispose of excess nuclear materials, the Pit Disassembly and Conversion Facility (PDCF) is being designed and constructed to disassemble the weapon ''pits'' and convert the nuclear material to an oxide form for fabrication into reactor fuel at the separate Mixed Oxide Fuel Fabrication Facility. The PDCF design incorporates automation to the maximum extent possible to facilitate material safeguards, reduce worker dose, and improve processing efficiency. This includes provisions for automated guided vehicle movements for shipping containers, material transport via automated conveyor between processes, remote process control monitoring, and automated Nondestructive Assay product systems

  16. Capillarity-induced disassembly of virions in carbon nanotubes

    Energy Technology Data Exchange (ETDEWEB)

    Fan Xiaobin; Peng Wenchao; Li Yang; Li Xianyu; Zhang Guoliang; Zhang Fengbao [School of Chemical Engineering and Technology, Tianjin University, Tianjin (China); Barclay, J Elaine; Evans, David J [Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH (United Kingdom)], E-mail: fbzhang@tju.edu.cn

    2008-04-23

    Studying the transport and fate of viruses through nanochannels is of great importance. By using the nanochannel of a carbon nanotube (CNT) as an ideal model, we evaluated the possibility of capillarity-induced viral transport through a closely fitting nanochannel and explored the mechanisms involved. It is shown both experimentally and theoretically that Cowpea mosaic virus can enter CNTs by capillarity. However, when introduced into a nanotube the protein capsid may disassemble. During the initial capillary filling stage, anomalous needle-shaped high pressure exists in the centre of the nanotube's entrance. This high pressure, combining with the significant negative pressure within the nanotube, may account for the disassembly of the virions.

  17. Status of the pit disassembly and conversion facility

    International Nuclear Information System (INIS)

    Wood, Warren T.; Christensen, Lowell T.

    2000-01-01

    A planned new facility, the Pit Disassembly and Conversion Facility (PDCF), will be used to disassemble the nation's inventory of surplus nuclear weapons pits and convert the plutonium from those pits into a form suitable for storage, international inspection, and final disposition. Sized to handle 35 metric tons of plutonium from pits and other sources over its 10-year operating life, the PDCF will apply the Advanced Recovery and Integrated Extraction System (ARIES) technology. ARIES process technology has been developed at Los Alamos National Laboratory (LANL) and Lawrence Livermore National Laboratory (LLNL), and an integrated system is being demonstrated at LANL. The Los Alamos National Laboratory is the lead for technical design oversight of the PDCF. Technical data gained from the ARIES demonstrations is integral for the proper design of the PDCF

  18. On the optimal design of the disassembly and recovery processes.

    Science.gov (United States)

    Xanthopoulos, A; Iakovou, E

    2009-05-01

    This paper tackles the problem of the optimal design of the recovery processes of the end-of-life (EOL) electric and electronic products, with a special focus on the disassembly issues. The objective is to recover as much ecological and economic value as possible, and to reduce the overall produced quantities of waste. In this context, a medium-range tactical problem is defined and a novel two-phased algorithm is presented for a remanufacturing-driven reverse supply chain. In the first phase, we propose a multicriteria/goal-programming analysis for the identification and the optimal selection of the most 'desirable' subassemblies and components to be disassembled for recovery, from a set of different types of EOL products. In the second phase, a multi-product, multi-period mixed-integer linear programming (MILP) model is presented, which addresses the optimization of the recovery processes, while taking into account explicitly the lead times of the disassembly and recovery processes. Moreover, a simulation-based solution approach is proposed for capturing the uncertainties in reverse logistics. The overall approach leads to an easy-to-use methodology that could support effectively middle level management decisions. Finally, the applicability of the developed methodology is illustrated by its application on a specific case study.

  19. On the optimal design of the disassembly and recovery processes

    International Nuclear Information System (INIS)

    Xanthopoulos, A.; Iakovou, E.

    2009-01-01

    This paper tackles the problem of the optimal design of the recovery processes of the end-of-life (EOL) electric and electronic products, with a special focus on the disassembly issues. The objective is to recover as much ecological and economic value as possible, and to reduce the overall produced quantities of waste. In this context, a medium-range tactical problem is defined and a novel two-phased algorithm is presented for a remanufacturing-driven reverse supply chain. In the first phase, we propose a multicriteria/goal-programming analysis for the identification and the optimal selection of the most 'desirable' subassemblies and components to be disassembled for recovery, from a set of different types of EOL products. In the second phase, a multi-product, multi-period mixed-integer linear programming (MILP) model is presented, which addresses the optimization of the recovery processes, while taking into account explicitly the lead times of the disassembly and recovery processes. Moreover, a simulation-based solution approach is proposed for capturing the uncertainties in reverse logistics. The overall approach leads to an easy-to-use methodology that could support effectively middle level management decisions. Finally, the applicability of the developed methodology is illustrated by its application on a specific case study

  20. A balance of activity in brain control and reward systems predicts self-regulatory outcomes.

    Science.gov (United States)

    Lopez, Richard B; Chen, Pin-Hao A; Huckins, Jeremy F; Hofmann, Wilhelm; Kelley, William M; Heatherton, Todd F

    2017-05-01

    Previous neuroimaging work has shown that increased reward-related activity following exposure to food cues is predictive of self-control failure. The balance model suggests that self-regulation failures result from an imbalance in reward and executive control mechanisms. However, an open question is whether the relative balance of activity in brain systems associated with executive control (vs reward) supports self-regulatory outcomes when people encounter tempting cues in daily life. Sixty-nine chronic dieters, a population known for frequent lapses in self-control, completed a food cue-reactivity task during an fMRI scanning session, followed by a weeklong sampling of daily eating behaviors via ecological momentary assessment. We related participants' food cue activity in brain systems associated with executive control and reward to real-world eating patterns. Specifically, a balance score representing the amount of activity in brain regions associated with self-regulatory control, relative to automatic reward-related activity, predicted dieters' control over their eating behavior during the following week. This balance measure may reflect individual self-control capacity and be useful for examining self-regulation success in other domains and populations. © The Author (2017). Published by Oxford University Press.

  1. Cofilin phosphorylation is elevated after F-actin disassembly induced by Rac1 depletion.

    Science.gov (United States)

    Liu, Linna; Li, Jing; Zhang, Liwang; Zhang, Feng; Zhang, Rong; Chen, Xiang; Brakebusch, Cord; Wang, Zhipeng; Liu, Xinyou

    2015-01-01

    Cytoskeletal reorganization is essential to keratinocyte function. Rac1 regulates cytoskeletal reorganization through signaling pathways such as the cofilin cascade. Cofilin severs actin filaments after activation by dephosphorylation. Rac1 was knocked out in mouse keratinocytes and it was found that actin filaments disassembled. In the epidermis of mice in which Rac1 was knocked out only in keratinocytes, cofilin phosphorylation was aberrantly elevated, corresponding to repression of the phosphatase slingshot1 (SSH1). These effects were independent of the signaling pathways for p21-activated kinase/LIM kinase (Pak/LIMK), protein kinase C, or protein kinase D or generation of reactive oxygen species. Similarly, when actin polymerization was specifically inhibited or Rac1 was knocked down, cofilin phosphorylation was enhanced and SSH1 was repressed. Repression of SSH1 partially blocked actin depolymerization induced by Rac1 depletion. Therefore, aberrant cofilin phosphorylation that induces actin polymerization might be a consequence of actin disassembly induced by the absence of Rac1. © 2015 International Union of Biochemistry and Molecular Biology.

  2. Changes in muscle activation following balance and technique training and a season of Australian football.

    Science.gov (United States)

    Donnelly, C J; Elliott, B C; Doyle, T L A; Finch, C F; Dempsey, A R; Lloyd, D G

    2015-05-01

    Determine if balance and technique training implemented adjunct to 1001 male Australian football players' training influenced the activation/strength of the muscles crossing the knee during pre-planned and unplanned sidestepping. Randomized Control Trial. Each Australian football player participated in either 28 weeks of balance and technique training or 'sham' training. Twenty-eight Australian football players (balance and technique training, n=12; 'sham' training, n=16) completed biomechanical testing pre-to-post training. Peak knee moments and directed co-contraction ratios in three degrees of freedom, as well as total muscle activation were calculated during pre-planned and unplanned sidestepping. No significant differences in muscle activation/strength were observed between the 'sham' training and balance and technique training groups. Following a season of Australian football, knee extensor (p=0.023) and semimembranosus (p=0.006) muscle activation increased during both pre-planned sidestepping and unplanned sidestepping. Following a season of Australian football, total muscle activation was 30% lower and peak valgus knee moments 80% greater (p=0.022) during unplanned sidestepping when compared with pre-planned sidestepping. When implemented in a community level training environment, balance and technique training was not effective in changing the activation of the muscles crossing the knee during sidestepping. Following a season of Australian football, players are better able to support both frontal and sagittal plane knee moments. When compared to pre-planned sidestepping, Australian football players may be at increased risk of anterior cruciate ligament injury during unplanned sidestepping in the latter half of an Australian football season. Copyright © 2014 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  3. Active Learning and Just-in-Time Teaching in a Material and Energy Balances Course

    Science.gov (United States)

    Liberatore, Matthew W.

    2013-01-01

    The delivery of a material and energy balances course is enhanced through a series of in-class and out-of-class exercises. An active learning classroom is achieved, even at class sizes over 150 students, using multiple instructors in a single classroom, problem solving in teams, problems based on YouTube videos, and just-in-time teaching. To avoid…

  4. Newcomer Psychological Contracts and Employee Socialization Activities: Does Perceived Balance in Obligations Matter?

    Science.gov (United States)

    Payne, Stephanie C.; Culbertson, Satoris S.; Boswell, Wendy R.; Barger, Eric J.

    2008-01-01

    We sought to determine the extent to which one's beliefs about the relationship between an employee and an organization at the start of employment influence subsequent socialization activities. The balance of employee exchange relationships, employee perceptions of both their own obligations and the employers' obligations, were collected from 120…

  5. Relationship Between Self-Regulation and Balance-Confidence in Active and Inactive Elderly Men

    Directory of Open Access Journals (Sweden)

    Fatemeh Sadat Hosseini

    2018-01-01

    Conclusion This study confirms that lack of self-regulation in the elderly can lead to decreased physical activity and restrictions. It is suggested that self-regulation should be emphasized in the elderly so that they can overcome their environmental issues and enhance their balance confidence.

  6. Teaching Children To Love: 80 Games & Fun Activities for Raising Balanced Children in Unbalanced Times.

    Science.gov (United States)

    Childre, Doc Lew; Paddison, Sara Hatch, Ed.

    Raising children in today's fast-paced society requires love and technique. Ways that parents can teach children to love, teach them values, and help them balance their lives are discussed in this activity book. The text opens with a discussion of heart intelligence (what is sometimes equated with emotional intelligence). Heart intelligence…

  7. Ninth Graders' Energy Balance Knowledge and Physical Activity Behavior: An Expectancy-Value Perspective

    Science.gov (United States)

    Chen, Senlin; Chen, Ang

    2012-01-01

    Expectancy beliefs and task values are two essential motivators in physical education. This study was designed to identify the relation between the expectancy-value constructs (Eccles & Wigfield, 1995) and high school students' physical activity behavior as associated with their energy balance knowledge. High school students (N = 195) in two…

  8. Impact of Balance Confidence on Daily Living Activities of Older People with Knee Osteoarthritis with Regard to Balance, Physical Function, Pain, and Quality of Life - A Preliminary Report.

    Science.gov (United States)

    Bobić Lucić, Lana; Grazio, Simeon

    2018-01-01

    The objective of this study was to explore the impact of balance confidence on different activities of daily living (ADL) in older people with knee osteoarthritis (OA). Forty-seven consecutive participants with knee OA were included in this cross-sectional study. They were divided according to the results of the Activities-specific Balance Confidence (ABC) Scale into a group with a low level of confidence in physical functioning (ABC balance measurements. Older people with knee OA who were less confident in their daily physical activities had more physical difficulties and a greater effect of pain on ADL, lower quality of life, and a higher physician's global assessment, but no differences were obtained in balance tests. In people with knee OA, decreased balance confidence is associated with more physical difficulties, an increased effect of pain on ADL, and lower quality of life. An improved awareness of decreased balance confidence may lead to more effective management of older people with knee OA by improving their mobility and QOL through rehabilitation. Furthermore, future research in that direction is warranted.

  9. Muscles Activity in the elderly with Balance Impairments in walking under Dual tasks

    Directory of Open Access Journals (Sweden)

    Elaheh Azadian

    2016-09-01

    Full Text Available Objectives: Each step during gait requires different attention demands that will affect muscles activity. The study of changes in the timing and intensity of the muscles activity in walking with dual task has received less attention from researchers. The purpose of this study was to evaluate changes in electromyography patterns of gait with cognitive dual tasks in balance impaired elderly. Methods: Thirty older adults were recruited for this study. People were selected through berg balance test. Subjects walked 12-meters in two conditions, normal walking and walking with a cognitive dual task. Spatial-temporal kinematic parameters were recorded through the motion analysis and muscles activities were recorded through electromyography system. The data obtained was analyzed using repeated measures ANOVA at a significant level of p< 0.05.  Results: The results showed that walking under dual tasks would decrease gait speed and increase stride time and stance time. Also muscle activity in Tibialis anterior and Vastus lateralis in stance-phase would decrease significantly in dual tasks as compared with single task (p< 0.05, but timing of muscle activity would not change in dual task conditions.  Conclusions: Based on the results, it can be argued that walking under a dual task can change spatial-temporal parameters and muscle activity in gait pattern in the elderly with balance impairment. One explanation could be that the decreased control of the central nervous system on muscle activity in stance phase due to the performing of a dual task.

  10. The use of Total Body In Vivo Neutron Activation Analysis (TBIVNAA) in balance studies in rodents

    International Nuclear Information System (INIS)

    Smith, D.A.; Lindsay, R.L.; Anderson, J.

    1976-01-01

    In the investigation of animals subject to alteration in diet or other metabolic experiments, the measurements of change in body calcium, phosphorus, sodium and nitrogen are of considerable interest. However, conventional balance studies are tedious and subject to both random and cumulative error, necessitating as they do accurate estimates of dietary intake and faecal and urinary output. The object of the present study was to determine the usefulness of total body in vivo neutron activation analysis, used at the beginning and end of the experimental period, as an alternative to conventional balance techniques. (orig.) [de

  11. Developmental programming of energy balance regulation: is physical activity more 'programmable' than food intake?

    Science.gov (United States)

    Zhu, Shaoyu; Eclarinal, Jesse; Baker, Maria S; Li, Ge; Waterland, Robert A

    2016-02-01

    Extensive human and animal model data show that environmental influences during critical periods of prenatal and early postnatal development can cause persistent alterations in energy balance regulation. Although a potentially important factor in the worldwide obesity epidemic, the fundamental mechanisms underlying such developmental programming of energy balance are poorly understood, limiting our ability to intervene. Most studies of developmental programming of energy balance have focused on persistent alterations in the regulation of energy intake; energy expenditure has been relatively underemphasised. In particular, very few studies have evaluated developmental programming of physical activity. The aim of this review is to summarise recent evidence that early environment may have a profound impact on establishment of individual propensity for physical activity. Recently, we characterised two different mouse models of developmental programming of obesity; one models fetal growth restriction followed by catch-up growth, and the other models early postnatal overnutrition. In both studies, we observed alterations in body-weight regulation that persisted to adulthood, but no group differences in food intake. Rather, in both cases, programming of energy balance appeared to be due to persistent alterations in energy expenditure and spontaneous physical activity (SPA). These effects were stronger in female offspring. We are currently exploring the hypothesis that developmental programming of SPA occurs via induced sex-specific alterations in epigenetic regulation in the hypothalamus and other regions of the central nervous system. We will summarise the current progress towards testing this hypothesis. Early environmental influences on establishment of physical activity are likely an important factor in developmental programming of energy balance. Understanding the fundamental underlying mechanisms in appropriate animal models will help determine whether early life

  12. Determination of the Optimal Position of Pendulums of an Active Self-balancing Device

    OpenAIRE

    Ziyakaev, Gregory Rakitovich; Kazakova, Oksana Aleksandrovna; Yankov, V. V.; Ivkina, O. P.

    2017-01-01

    The demand of the modern manufacturing industry for machines with high motion speed leads to increased load and vibration activity of the main elements of rotor systems. Vibration reduces operating life of bearings, has adversary effects on human organism, and can cause accidents. One way to compensate for a rotating rotor's imbalance is the use of active self-balancing devices. The aim of this work is to determine the position of their pendulums, in which the imbalance is minimized. As a res...

  13. [Study on the liver-protective and choleretic effect of zhizi baipi soup and its disassembled prescription].

    Science.gov (United States)

    Xiao, Xu; Zhu, Ji-Xiao; Luo, Guang-Ming; Li, Lei; Zhu, Yu-Ye; Zeng, Jin-Xiang; Wang, Xiao-Yun; Wu, Bo

    2013-07-01

    To investigate the effect of Zhizi Baipi soup and its disassembled prescription on protecting liver and improving choleresis and explore the regularity of Zhizi Baipi soup composition. The model of mouse liver injury induced by carbon tetraehlofide (CCl4) was used to observe the effects of Zhizi Baipi soup and its disassembled prescription by oral adminstration, the bile volume was determinied by common bile duct drainage. Zhizi Baipi soup and each treatment group with gardenia could significantly inhibit the increased serum ATL and AST activities, reduce liver MDA level, and significantly promote the bile flow and bilirubin in bile in normal rats. Zhizi Baipi soup has effects on protecting liver and increasing bile secretion, its monarch drug, gardenia plays an important role in the decoction, the effect of eliminating dampness and heat are mainly ascribed to the synergic effect of gardenia and phellodendron.

  14. The development of underwater remote cutting method for the disassembling of rotary specimen rack KRR-1 and 2

    Energy Technology Data Exchange (ETDEWEB)

    Lee, D. K.; Jung, K. H.; Lee, K. W.; Oh, W. J. [KAERI, Taejon (Korea, Republic of); Lee, K. Y. [Korea Institute of Industrial Technology, Kwangju (Korea, Republic of)

    2004-07-01

    The Rotary Specimen Racks (RSRs) were highly activated and then classified intermediate level radioactive waste for the decommissioning of KRR-1anel2. The RSR can be treated as low level radioactive waste after removing stainless steel parts. To reduce the volume of intermediate level radioactive waste, underwater cutting is required to separate stainless steel parts from RSR because of high radioactivity. In this study, the automatic remote cutting method was developed to disassemble RSR under water. For automatic remote cutting processes, a CAM (Computer Aided Manufacturing) system is employed. A computer inputs NC (Numerical Control) codes to the controller, which are based on CAM model, and the controller instructs the equipment to process according to NC codes automatically. And the cutting force model was improved to cut RSR stably. The automatic cutting was conducted using imitation of RSR and then it was resulted that the developed automatic cutting method can be safely disassemble stainless steel parts of RSR under water.

  15. Asymmetric ring structure of Vps4 required for ESCRT-III disassembly

    Science.gov (United States)

    Caillat, Christophe; Macheboeuf, Pauline; Wu, Yuanfei; McCarthy, Andrew A.; Boeri-Erba, Elisabetta; Effantin, Gregory; Göttlinger, Heinrich G.; Weissenhorn, Winfried; Renesto, Patricia

    2015-12-01

    The vacuolar protein sorting 4 AAA-ATPase (Vps4) recycles endosomal sorting complexes required for transport (ESCRT-III) polymers from cellular membranes. Here we present a 3.6-Å X-ray structure of ring-shaped Vps4 from Metallosphera sedula (MsVps4), seen as an asymmetric pseudohexamer. Conserved key interface residues are shown to be important for MsVps4 assembly, ATPase activity in vitro, ESCRT-III disassembly in vitro and HIV-1 budding. ADP binding leads to conformational changes within the protomer, which might propagate within the ring structure. All ATP-binding sites are accessible and the pseudohexamer binds six ATP with micromolar affinity in vitro. In contrast, ADP occupies one high-affinity and five low-affinity binding sites in vitro, consistent with conformational asymmetry induced on ATP hydrolysis. The structure represents a snapshot of an assembled Vps4 conformation and provides insight into the molecular motions the ring structure undergoes in a concerted action to couple ATP hydrolysis to ESCRT-III substrate disassembly.

  16. Disassembly of JT-60 tokamak device and ancillary facilities for JT-60 tokamak

    International Nuclear Information System (INIS)

    Okano, Fuminori; Ichige, Hisashi; Miyo, Yasuhiko; Kaminaga, Atsushi; Sasajima, Tadayuki; Nishiyama, Tomokazu; Yagyu, Jun-ichi; Ishige, Youichi; Suzuki, Hiroaki; Komuro, Kenichi; Sakasai, Akira; Ikeda, Yoshitaka

    2014-03-01

    The disassembly of JT-60 tokamak device and its peripheral equipments, where the total weight was about 5400 tons, started in 2009 and accomplished in October 2012. This disassembly was required process for JT-60SA project, which is the Satellite Tokamak project under Japan-EU international corroboration to modify the JT-60 to the superconducting tokamak. This work was the first experience of disassembling a large radioactive fusion device based on Radiation Hazard Prevention Act in Japan. The cutting was one of the main problems in this disassembly, such as to cut the welded parts together with toroidal field coils, and to cut the vacuum vessel into two. After solving these problems, the disassembly completed without disaster and accident. This report presents the outline of the JT-60 disassembly, especially tokamak device and ancillary facilities for tokamak device. (author)

  17. The effect of activity history and current activity on static and dynamic postural balance in older adults.

    Science.gov (United States)

    Bulbulian, R; Hargan, M L

    2000-01-01

    The purpose of this study was to investigate the effects of former athleticism and current activity status on static and dynamic postural balance in older adults. Fifty-six subjects participated in four study groups including former athletes, currently active (AA; n = 15; 69.1+/-4.4 years.; 77.8+/-9.8 kg), former athletes, currently inactive (AI; n = 12; 66.7 years.; 87.2+/-15.1 kg), controls currently active (CA; n = 14; 68.6 +/- 4.5 years.; 73.9+/-15 kg), and controls currently inactive (CI; n = 15; 72.8+/-4.8 years; 81.1+/-14.8). All subjects were tested for height, weight, flexibility, thigh circumference, and static (sharpened Romberg/unipedal stance), and dynamic (step length and width) balance tests. The sharpened Romberg (eyes open) test showed that AA (60.0+/-0 s) and CA (59.4+/- 0.5 s) balanced significantly longer than AI (41.5+/-7.2 s), and CI (41.8+/-6.1 s) (punipedal (eyes open) test balance scores for AA, CA, AI, and CI were respectively 40.0+/-4.5, 55.1+/- 3.4, 33.0+/-7.1, and 27.5+/-6.1 s, with CA significantly better than CI (ptest results for relative group comparisons were similar. Overall, two-way analysis of variance showed a significant activity main effect for all dependent variables measured (p<0.05). The results indicated that current activity status plays a key role on balance performance in older adults. Furthermore, former athletic activity history provides no protection for the age related onset of postural imbalance.

  18. Spent fuel disassembly and canning programs at the Barnwell Nuclear Fuel Plant (BNFP)

    International Nuclear Information System (INIS)

    Townes, G.A.

    1979-10-01

    Methods of disassembling and canning spent fuel to allow more efficient storage are being investigated at the BNFP. Studies and development programs are aimed at dry disassembly of fuel to allow storage and shipment of fuel pins rather than full fuel assemblies. Results indicate that doubling existing storage capacity or tripling the carrying capacity of existing transportation equipment is achievable. Disassembly could be performed in the BNFP hot cells at rates of about 12 to 15 assemblies per day

  19. Application of industrial robots in automatic disassembly line of waste LCD displays

    Science.gov (United States)

    Wang, Sujuan

    2017-11-01

    In the automatic disassembly line of waste LCD displays, LCD displays are disassembled into plastic shells, metal shields, circuit boards, and LCD panels. Two industrial robots are used to cut metal shields and remove circuit boards in this automatic disassembly line. The functions of these two industrial robots, and the solutions to the critical issues of model selection, the interfaces with PLCs and the workflows were described in detail in this paper.

  20. State-of-Charge Estimation and Active Cell Pack Balancing Design of Lithium Battery Power System for Smart Electric Vehicle

    Directory of Open Access Journals (Sweden)

    Z. C. Gao

    2017-01-01

    Full Text Available This paper presents an integrated state-of-charge (SOC estimation model and active cell balancing of a 12-cell lithium iron phosphate (LiFePO4 battery power system. The strong tracking cubature extended Kalman filter (STCEKF gave an accurate SOC prediction compared to other Kalman-based filter algorithms. The proposed groupwise balancing of the multiple SOC exhibited a higher balancing speed and lower balancing loss than other cell balancing designs. The experimental results demonstrated the robustness and performance of the battery when subjected to current load profile of an electric vehicle under varying ambient temperature.

  1. Corrosion of aluminum alloys in a reactor disassembly basin

    International Nuclear Information System (INIS)

    Howell, J.P.; Zapp, P.E.; Nelson, D.Z.

    1992-01-01

    This document discusses storage of aluminum clad fuel and target tubes of the Mark 22 assembly takes place in the concrete-lined, light-water-filled, disassembly basins located within each reactor area at the Savannah River Site (SRS). A corrosion test program has been conducted in the K-Reactor disassembly basin to assess the storage performance of the assemblies and other aluminum clad components in the current basin environment. Aluminum clad alloys cut from the ends of actual fuel and target tubes were originally placed in the disassembly water basin in December 1991. After time intervals varying from 45--182 days, the components were removed from the basin, photographed, and evaluated metallographically for corrosion performance. Results indicated that pitting of the 8001 aluminum fuel clad alloy exceeded the 30-mil (0.076 cm) cladding thickness within the 45-day exposure period. Pitting of the 1100 aluminum target clad alloy exceeded the 30-mil (0.076 cm) clad thickness in 107--182 days exposure. The existing basin water chemistry is within limits established during early site operations. Impurities such as Cl - , NO 3 - and SO 4 - are controlled to the parts per million level and basin water conductivity is currently 170--190 μmho/cm. The test program has demonstrated that the basin water is aggressive to the aluminum components at these levels. Other storage basins at SRS and around the US have successfully stored aluminum components for greater than ten years without pitting corrosion. These basins have impurity levels controlled to the parts per billion level (1000X lower) and conductivity less than 1.0 μmho/cm

  2. Influence of regular proprioceptive and bioenergetic physical activities on balance control in elderly women.

    Science.gov (United States)

    Gauchard, Gérome C; Gangloff, Pierre; Jeandel, Claude; Perrin, Philippe P

    2003-09-01

    Balance disorders increase considerably with age due to a decrease in posture regulation quality, and are accompanied by a higher risk of falling. Conversely, physical activities have been shown to improve the quality of postural control in elderly individuals and decrease the number of falls. The aim of this study was to evaluate the impact of two types of exercise on the visual afferent and on the different parameters of static balance regulation. Static postural control was evaluated in 44 healthy women aged over 60 years. Among them, 15 regularly practiced proprioceptive physical activities (Group I), 12 regularly practiced bioenergetic physical activities (Group II), and 18 controls walked on a regular basis (Group III). Group I participants displayed lower sway path and area values, whereas Group III participants displayed the highest, both in eyes-open and eyes-closed conditions. Group II participants displayed intermediate values, close to those of Group I in the eyes-open condition and those of Group III in the eyes-closed condition. Visual afferent contribution was more pronounced for Group II and III participants than for Group I participants. Proprioceptive exercise appears to have the best impact on balance regulation and precision. Besides, even if bioenergetic activity improves postural control in simple postural tasks, more difficult postural tasks show that this type of activity does not develop a neurosensorial proprioceptive input threshold as well, probably on account of the higher contribution of visual afferent.

  3. 401(k) plan asset allocation, account balances, and loan activity in 1998.

    Science.gov (United States)

    VanDerhei, J; Holden, S; Quick, C

    2000-02-01

    The Employee Benefit Research Institute (EBRI) and the Investment Company Institute (ICI) have been collaborating for the past three years to collect data on participants in 401(k) plans. This effort, known as the EBRI/ICI Participant-Directed Retirement Plan Data Collection Project, has obtained data for 401(k) plan participants from certain of EBRI and ICI members serving as plan record keepers and administrators. The report includes 1998 information on 7.9 million active participants in 30,102 plans holding nearly $372 billion in assets. The data include demographic information, annual contributions, plan balances, asset allocation, and loans, and are broadly representative of the universe of 401(k) plans. The database also includes three years of longitudinal information on approximately 3.3 million participants. Key findings include: For all 401(k) participants in the 1998 EBRI/ICI database, almost three-quarters of plan balances are invested directly or indirectly in equity securities. Specifically, 49.8 percent of total plan balances are invested in equity funds, 17.7 percent in company stock, 11.4 percent in guaranteed investment contracts (GICs), 8.4 percent in balanced funds, 6.1 percent in bond funds, 4.7 percent in money funds, and 0.3 percent in other stable value funds. Participant asset allocation varies considerably with age. Younger participants tend to favor equity funds, while older participants are more disposed to invest in GICs and bond funds. On average, participants in their 20s have 62.1 percent of their account balances invested in equity funds, in contrast to 39.8 percent for those in their 60s. Participants in their 20s invest 4.7 percent of their assets in GICs, while those in their 60s invest 20.6 percent. Bond funds, which represent 4.7 percent of the assets of participants in their 20s, amount to 9.0 percent of the assets of participants in their 60s. Investment options offered by 401(k) plans appear to influence asset allocation

  4. THEORETICAL AND PRACTICAL ASPECTS OF EXPLORATION THE INNOVATIVE ACTIVE ORGANIZATIONS’ POTENTIAL OF A BALANCED DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    A. I. Khorev

    2014-01-01

    Full Text Available Summary. The concept of "potential" put into practice as a method of study permits the uncertainty associated with the absence of any information about the conditions of functioning in the future. Critical importance is the study of the potential development of an economic entity. S.I. Ozhegov noted that development - natural process changes, the transition from one state to another, more perfect, the transition from an old qualitative state to a new, simple to complex, from lowest to highest. The essential content of balanced development potential based on study of the relationship concepts of «potential of the company», «the development of an economic entity», «balanced development» have been considered in the article. Particular attention is paid to the specifics of development of innovation-active organizations. Conclusion has been made that to the timely detection of potential balanced development need a comprehensive analysis of the conditions and factors functioning economic entity, which have been grouped into three groups: factors of macro, meso and micro level. A comprehensive study of the factors determining the future development of innovation-active enterprises has been conducted in the article. It is shown that the effectiveness of the balanced development of innovation-active organizations in general, and the object of research , in particular , is determined by such factors as the structure and needs of the market , the resource base of innovative development , effective management system development, innovation activity . The authors believe that the inclusion of the multifaceted impact of factors will allow innovative active organizations to build a control system which allows more accurately predict the perspective direction of their future development.

  5. Water-filled training tubes increase core muscle activation and somatosensory control of balance during squat.

    Science.gov (United States)

    Ditroilo, Massimiliano; O'Sullivan, Rory; Harnan, Brian; Crossey, Aislinn; Gillmor, Beth; Dardis, William; Grainger, Adam

    2018-09-01

    This study examined trunk muscle activation, balance and proprioception while squatting with a water-filled training tube (WT) and a traditional barbell (BB), with either closed (CE) or open eyes (OE). Eighteen male elite Gaelic footballers performed an isometric squat under the following conditions: BB-OE, BB-CE, WT-OE and WT-CE. The activity of rectus abdominis (RA), external oblique (EO) and multifidus (MF) was measured using electromyography, along with sway of the centre of pressure (CoP) using a force platform. Only the EO and the MF muscles exhibited an increased activity with WT (p velocity and range of the CoP increased significantly with WT (p velocity of the CoP was marginally reduced (d = 0.29). WT elicited a greater level core muscle activation and created a greater challenge to postural stability when compared to a BB. It appears that WT does not benefit from vision but emphasises the somatosensory control of balance. The use of WT may be beneficial in those sports requiring development of somatosensory/proprioceptive contribution to balance control.

  6. Spent fuel disassembly hardware and other non-fuel bearing components: characterization, disposal cost estimates, and proposed repository acceptance requirements

    Energy Technology Data Exchange (ETDEWEB)

    Luksic, A.T.; McKee, R.W.; Daling, P.M.; Konzek, G.J.; Ludwick, J.D.; Purcell, W.L.

    1986-10-01

    There are two categories of waste considered in this report. The first is the spent fuel disassembly (SFD) hardware. This consists of the hardware remaining after the fuel pins have been removed from the fuel assembly. This includes end fittings, spacer grids, water rods (BWR) or guide tubes (PWR) as appropriate, and assorted springs, fasteners, etc. The second category is other non-fuel-bearing (NFB) components the DOE has agreed to accept for disposal, such as control rods, fuel channels, etc., under Appendix E of the standard utiltiy contract (10 CFR 961). It is estimated that there will be approximately 150 kg of SFD and NFB waste per average metric ton of uranium (MTU) of spent uranium. PWR fuel accounts for approximately two-thirds of the average spent-fuel mass but only 50 kg of the SFD and NFB waste, with most of that being spent fuel disassembly hardware. BWR fuel accounts for one-third of the average spent-fuel mass and the remaining 100 kg of the waste. The relatively large contribution of waste hardware in BWR fuel, will be non-fuel-bearing components, primarily consisting of the fuel channels. Chapters are devoted to a description of spent fuel disassembly hardware and non-fuel assembly components, characterization of activated components, disposal considerations (regulatory requirements, economic analysis, and projected annual waste quantities), and proposed acceptance requirements for spent fuel disassembly hardware and other non-fuel assembly components at a geologic repository. The economic analysis indicates that there is a large incentive for volume reduction.

  7. Changes in cortical activity associated with adaptive behavior during repeated balance perturbation of unpredictable timing

    Directory of Open Access Journals (Sweden)

    Andreas eMierau

    2015-10-01

    Full Text Available The compensation for a sudden balance perturbation, unpracticed and unpredictable in timing and magnitude is accompanied by pronounced postural instability that is suggested to be causal to falls. However, subsequent presentations of an identical perturbation are characterized by a marked decrease of the amplitude of postural reactions; a phenomenon called adaptation or habituation. This study aimed to identify cortical characteristics associated with adaptive behavior during repetitive balance perturbations based on single-trial analyses of the P1 and N1 perturbation-evoked potentials. Thirty-seven young men were exposed to ten transient balance perturbations while balancing on the dominant leg. 32-channel EEG, surface EMG of the ankle plantar flexor muscles and postural sway (i.e. Euclidean distance of the supporting platform were recorded simultaneously. The P1 and N1 potentials were localized and the amplitude/latency was analyzed trial by trial. The best match sources for P1 and N1 potentials were located in the parietal (Brodmann area 5 and midline fronto-central cortex (Brodmann area 6, respectively. The amplitude and latency of the P1 potential remained unchanged over trials. In contrast, a significant adaptation of the N1 amplitude was observed. Similar adaptation effects were found with regard to postural sway and m. peroneus longus EMG activity of the non-dominant (free leg; an indicator reduced muscular co-contraction and/or less temporary bipedal stance to regain stability. Significant but weak correlations were found between N1 amplitude and postural sway as well as EMG activity. These results highlight the important role of the midline fronto-central cortex for adaptive behavior associated with balance control.

  8. 401(k) plan asset allocation, account balances, and loan activity in 2007.

    Science.gov (United States)

    VanDerhei, Jack; Holden, Sarah; Alonso, Luis; Copeland, Craig

    2008-12-01

    The bulk of 401(k) assets continued to be invested in stocks. On average, at year-end 2007, about two-thirds of 401(k) participants' assets were invested in equity securities through equity funds, the equity portion of balanced funds, and company stock. About one-third was in fixed-income securities such as stable value investments and bond and money market funds. Although these relative shares have changed little over the past 12 years, the underlying fund composition has changed over time. About two-thirds of 401(k) plans included lifecycle funds in their investment lineup at year-end 2007. New analysis shows that at year-end 2007, more than 7 percent of the assets in the EBRI/ICI database were invested in lifecycle funds and one-quarter of 401(k) participants held lifecycle funds. Also known as "target date" funds, they are designed to simplify investing and automate account rebalancing. New employees continued to utilize balanced funds, including lifecyclefunds. Across all age groups, more new or recent hires invested their 401(k) assets in balanced funds, including lifecycle funds. At year-end 2007, 28 percent of the account balances of recently hired participants in their 20s were invested in balanced funds, compared with 24 percent in 2006, 19 percent in 2005, and about 7 percent in 1998. At year-end 2007, almost 19 percent of the account balances of recently hired participants in their 20s were invested in lifecycle funds compared with 16 percent at year-end 2006. 401(k) participants continued to seek diversification of their investments. The share of 401(k) accounts invested in company stock continued to shrink, falling by 0.5 percentage point (to 10.6 percent) in 2007. That continued a steady decline that started in 1999. Recently hired 401(k) participants contributed to this trend: they were less likely to hold employer stock. Participants' 401(k) loan activity was stable. In 2007, 18 percent of all 401(k) participants eligible for loans had a loan

  9. Compact, Energy-Efficient High-Frequency Switched Capacitor Neural Stimulator With Active Charge Balancing.

    Science.gov (United States)

    Hsu, Wen-Yang; Schmid, Alexandre

    2017-08-01

    Safety and energy efficiency are two major concerns for implantable neural stimulators. This paper presents a novel high-frequency, switched capacitor (HFSC) stimulation and active charge balancing scheme, which achieves high energy efficiency and well-controlled stimulation charge in the presence of large electrode impedance variations. Furthermore, the HFSC can be implemented in a compact size without any external component to simultaneously enable multichannel stimulation by deploying multiple stimulators. The theoretical analysis shows significant benefits over the constant-current and voltage-mode stimulation methods. The proposed solution was fabricated using a 0.18 μm high-voltage technology, and occupies only 0.035 mm 2 for a single stimulator. The measurement result shows 50% peak energy efficiency and confirms the effectiveness of active charge balancing to prevent the electrode dissolution.

  10. Girls with generalized joint hypermobility display changed muscle activity and postural sway during static balance tasks

    DEFF Research Database (Denmark)

    Juul-Kristensen, B; Johansen, Kl; Hendriksen, P

    2016-01-01

    OBJECTIVES: To study knee muscle activity and static postural sway in girls with generalized joint hypermobility (GJH). METHOD: Sixteen girls with GJH and 11 girls with non-GJH (NGJH) aged 14 years, randomly recruited among schoolchildren, participated in this study. GJH inclusion criteria were......: Beighton score minimum 6/9 and one hypermobile knee; for NGJH: Beighton score maximum 5/9 and no knees with hypermobility. The participants performed a static two-legged balance test with eyes open (2EO) and eyes closed (2EC) and a one-legged stance test with eyes open (1EO). Postural sway (centre......) of Q, H, and G muscle activity was calculated. Knee function was self-reported using the Knee Injury and Osteoarthritis Outcome Score for children (KOOS-Child). RESULTS: GJH had a significantly lower lateral HQ CCI and a higher medial/lateral HQ CCI ratio in all balance tasks. Group mean EMG varied...

  11. Cofilin phosphorylation is elevated after F-actin disassembly induced by Rac1 depletion

    DEFF Research Database (Denmark)

    Liu, Linna; Li, Jing; Zhang, Liwang

    2015-01-01

    Cytoskeletal reorganization is essential to keratinocyte function. Rac1 regulates cytoskeletal reorganization through signaling pathways such as the cofilin cascade. Cofilin severs actin filaments after activation by dephosphorylation. Rac1 was knocked out in mouse keratinocytes and it was found...... that actin filaments disassembled. In the epidermis of mice in which Rac1 was knocked out only in keratinocytes, cofilin phosphorylation was aberrantly elevated, corresponding to repression of the phosphatase slingshot1 (SSH1). These effects were independent of the signaling pathways for p21-activated kinase....../LIM kinase (Pak/LIMK), protein kinase C, or protein kinase D or generation of reactive oxygen species. Similarly, when actin polymerization was specifically inhibited or Rac1 was knocked down, cofilin phosphorylation was enhanced and SSH1 was repressed. Repression of SSH1 partially blocked actin...

  12. Digital mock-up for the spent fuel disassembly processes

    International Nuclear Information System (INIS)

    Lee, J. Y.; Kim, S. H.; Song, T. G.; Kim, Y. H.; Hong, D. H.; Yoon, J. S.

    2000-12-01

    In this study, the graphical design system is developed and the digital mock-up is implemented for designing the spent fuel handling and disassembly processes. The system consists of a 3D graphical modeling system, a devices assembling system, and a motion simulation system. This system is used throughout the design stages from the conceptual design to the motion analysis. By using this system, all the process involved in the spent fuel handling and disassembly processes are analyzed and optimized. Also, this system is used in developing the on-line graphic simulator which synchronously simulates the motion of the equipment in a real time basis by connecting the device controllers with the graphic server through the TCP/IP network. This simulator can be effectively used for detecting the malfunctions of the process equipment which is remotely operated. Thus, the simulator enhances the reliability and safety of the spent fuel handling process by providing the remote monitoring function of the process. The graphical design system and the digital mock-up system can be effectively used for designing the process equipment, as well as the optimized process and maintenance process. And the on-line graphic simulator can be an alternative of the conventional process monitoring system which is a hardware based system

  13. ARIES pit disassembly-safeguards issues for transparency

    International Nuclear Information System (INIS)

    Fearey, B.L.; Cremers, T.L.

    1995-01-01

    Historic changes are now occurring in U.S. nonproliferation and arms control policy. The quantity of nuclear weapons required to provide a deterrence has decreased (especially with the end of the Cold War). Further, various bilateral and multilateral treaties now require the removal of numerous nuclear weapons from the U.S. stockpile. Although the removal of such weapons appears straightforward, the final disposition of the surplus weapons-grade nuclear material must be carefully considered. Domestically, several plutonium disposition plans are now under consideration concerning long-term safety, materials accounting, environmental impact, accessibility, and long-term containment. The Automated Retirement and Integrated Extraction System (ARIES) currently under development at Los Alamos National Laboratory is one such disposition method for the disassembly of plutonium weapons components (pits). The ARIES system integrates and automates several features: disassembly of pits, consolidation of the plutonium material, on-line measurement of final products, waste streams, and long-term packaging. Clearly, in any plutonium disposition plan, the safeguards aspects of materials control and accounting and the security aspects must be carefully considered and evaluated

  14. Resource Leveling Based on Backward Controlling Activity in Line of Balance

    Directory of Open Access Journals (Sweden)

    Lihui Zhang

    2017-01-01

    Full Text Available The line of balance method that provides continuous and uninterrupted use of resources is one of the best methods for repetitive project resource management. This paper develops a resource leveling algorithm based on the backward controlling activity in line of balance. The backward controlling activity is a kind of special activity, and if its duration is prolonged the project duration could be reduced. It brings two advantages to the resource leveling: both the resource allocated on the backward activity and the project duration are reduced. A resource leveling algorithm is presented which permits the number of crews of the backward controlling activity to be reduced until the terminal situation is reached, where the backward controlling activity does not exist or the number of crews cannot be reduced. That adjustment enables the productivity of all activities to be consistent. An illustrative pipeline project demonstrates the improvement in resource leveling. And this study designed a MATLAB program to execute the design algorithm. The proposed model could help practitioners to achieve the goals of both resource leveling and project duration reduction without increasing any resource.

  15. Effect of Ankle-foot Orthosis on Lower Limb Muscle Activities and Static Balance of Stroke Patients Authors’ Names

    OpenAIRE

    Lee, Youngmin; Her, Jin Gang; Choi, Youngeun; Kim, Heesoo

    2014-01-01

    [Purpose] This study examined the effects of an ankle-foot orthosis worn during balance training on lower limb muscle activity and static balance of chronic stroke patients. [Subjects] The subjects were twenty-five inpatients receiving physical therapy for chronic stroke. [Methods] The chronic stroke patients were divided into two groups: thirteen patients were assigned to the ankle-foot orthosis group, while the remaining twelve patients wore only their shoes. Each group performed balance tr...

  16. Stored Energy Balance for Distributed PV-Based Active Generators in an AC Microgrid

    DEFF Research Database (Denmark)

    Aldana, Nelson Leonardo Diaz; Wu, Dan; Dragicevic, Tomislav

    2015-01-01

    In this paper, a decentralized strategy based on fuzzy logic is proposed for balancing the state of charge of the energy storage units for distributed PV-based active generators. The proposed method, weights the action of conventional droop control loops for privileging the charge of the energy...... expandable and can be applied to a several number of power generators interconnected in a microgrid. Frequency and voltage bus signaling is used in order to coordinate the control operation mode between units. Simulation results in a low-voltage, three-phase, islanded AC microgrid show the feasibility...... of the proposed method and its applicability even for several active generators....

  17. Determination of the Optimal Position of Pendulums of an Active Self-balancing Device

    Science.gov (United States)

    Ziyakaev, G. R.; Kazakova, O. A.; Yankov, V. V.; Ivkina, O. P.

    2017-04-01

    The demand of the modern manufacturing industry for machines with high motion speed leads to increased load and vibration activity of the main elements of rotor systems. Vibration reduces operating life of bearings, has adversary effects on human organism, and can cause accidents. One way to compensate for a rotating rotor's imbalance is the use of active self-balancing devices. The aim of this work is to determine the position of their pendulums, in which the imbalance is minimized. As a result of the study, a formula for determining the angle of the pendulums was obtained.

  18. Movement and equipositioning of plasmids by ParA filament disassembly

    DEFF Research Database (Denmark)

    Ringgaard, Simon; van Zon, Jeroen; Howard, Martin

    2009-01-01

    , plasmids consistently migrate behind disassembling ParA cytoskeletal structures, suggesting that ParA filaments pull plasmids by depolymerization. The perpetual cycles of ParA assembly and disassembly result in continuous relocation of plasmids, which, on time averaging, results in equidistribution...

  19. Coordination of substrate binding and ATP hydrolysis in Vps4-mediated ESCRT-III disassembly.

    Science.gov (United States)

    Davies, Brian A; Azmi, Ishara F; Payne, Johanna; Shestakova, Anna; Horazdovsky, Bruce F; Babst, Markus; Katzmann, David J

    2010-10-01

    ESCRT-III undergoes dynamic assembly and disassembly to facilitate membrane exvagination processes including multivesicular body (MVB) formation, enveloped virus budding, and membrane abscission during cytokinesis. The AAA-ATPase Vps4 is required for ESCRT-III disassembly, however the coordination of Vps4 ATP hydrolysis with ESCRT-III binding and disassembly is not understood. Vps4 ATP hydrolysis has been proposed to execute ESCRT-III disassembly as either a stable oligomer or an unstable oligomer whose dissociation drives ESCRT-III disassembly. An in vitro ESCRT-III disassembly assay was developed to analyze Vps4 function during this process. The studies presented here support a model in which Vps4 acts as a stable oligomer during ATP hydrolysis and ESCRT-III disassembly. Moreover, Vps4 oligomer binding to ESCRT-III induces coordination of ATP hydrolysis at the level of individual Vps4 subunits. These results suggest that Vps4 functions as a stable oligomer that acts upon individual ESCRT-III subunits to facilitate ESCRT-III disassembly.

  20. 401(k) plan asset allocation, account balances, and loan activity in 2008.

    Science.gov (United States)

    VanDerhei, Jack; Holden, Sarah; Alonso, Luis

    2009-10-01

    28 percent in 2007, and about 7 percent in 1998. At year-end 2008, almost 23 percent of the account balances of recently hired participants in their 20s were invested in lifecycle funds, compared with almost 19 percent at year-end 2007. 401(K) PARTICIPANTS CONTINUED TO SEEK DIVERSIFICATION OF THEIR INVESTMENTS. The share of 401(k) accounts invested in company stock continued to shrink, falling by nearly 1 percentage point (to 9.7 percent) in 2008. That continued a steady decline that started in 1999. Recently hired 401(k) participants contributed to this trend: they were less likely to hold employer stock. PARTICIPANTS' 401(K) LOAN ACTIVITY WAS STABLE. In 2008, 18 percent of all 401(k) participants eligible for loans had a loan outstanding against their 401(k) account, the same percentage as at year-end 2007 and year-end 2006. Loans outstanding amounted to 16 percent of the remaining account balance, on average, at year-end 2008; this is similar to the year-end 2002 level.

  1. 401(k) plan asset allocation, account balances, and loan activity in 2009.

    Science.gov (United States)

    VanDerhei, Jack; Holden, Sarah; Alonso, Luis

    2010-11-01

    of the account balances of recently hired participants in their 20s were invested in balanced funds, compared with 36 percent in 2008, and about 7 percent in 1998. At year-end 2009, 31 percent of the account balances of recently hired participants in their 20s was invested in lifecycle funds, compared with almost 23 percent at year-end 2008. 401(K) PARTICIPANTS CONTINUED TO SEEK DIVERSIFICATION OF THEIR INVESTMENTS: The share of 401(k) accounts invested in company stock continued to shrink, falling by half of a percentage point (to 9.2 percent) in 2009. That continued a steady decline that started in 1999. Recently hired 401(k) participants contributed to this trend: They tended to be less likely to hold employer stock. PARTICIPANTS' 401(K) LOAN ACTIVITY ROSE IN 2009: In 2009, 21 percent of all 401(k) participants eligible for loans had a loan outstanding against their 401(k) account, compared with 18 percent at year-end 2008 and year-end 2007. Loans outstanding amounted to 15 percent of the remaining account balance, on average, at year-end 2009, compared with 16 percent at year-end 2008. Loan amounts remained in line with the past few years in terms of typical dollar amounts.

  2. 401(k) plan asset allocation, account balances, and loan activity in 2011.

    Science.gov (United States)

    VanDerhei, Jack; Holden, Sarah; Alonso, Luis; Bass, Steven

    2012-12-01

    THE BULK OF 401(K) ASSETS CONTINUED TO BE INVESTED IN STOCKS: On average, at year-end 2011, 61 percent of 401(k) participants' assets was invested in equity securities through equity funds, the equity portion of balanced funds, and company stock. Thirty-four percent was in fixed-income securities such as stable-value investments and bond and money funds. SEVENTY-TWO PERCENT OF 401(K) PLANS INCLUDED TARGET-DATE FUNDS IN THEIR INVESTMENT LINEUP AT YEAR-END 2011: At year-end 2011, 13 percent of the assets in the EBRI/ICI 401(k) database was invested in target-date funds and 39 percent of 401(k) participants held target-date funds. Also known as lifecycle funds, these funds are designed to offer a diversified portfolio that automatically rebalances to be more focused on income over time. MORE NEW OR RECENT HIRES INVESTED THEIR 401(K) ASSETS IN BALANCED FUNDS, INCLUDING TARGET-DATE FUNDS: For example, at year-end 2011, 51 percent of the account balances of recently hired participants in their 20s was invested in balanced funds, compared with 44 percent in 2010, and about 7 percent in 1998. A significant subset of that balanced fund category is target-date funds. At year-end 2011, 40 percent of the account balances of recently hired participants in their 20s was invested in target-date funds, compared with 35 percent at year-end 2010. 401(K) PARTICIPANTS CONTINUED TO SEEK DIVERSIFICATION OF THEIR INVESTMENTS: The share of 401(k) accounts invested in company stock remained at 8 percent in 2011. This share has fallen by more than half since 1999. Recently hired 401(k) participants contributed to this trend: They tended to be less likely to hold employer stock. PARTICIPANTS' 401(K) LOAN ACTIVITY REMAINED STEADY, ALTHOUGH LOAN BALANCES INCREASED SLIGHTLY IN 2011: At year-end 2011, 21 percent of all 401(k) participants who were eligible for loans had loans outstanding against their 401(k) accounts, unchanged from year-end 2009 and year-end 2010, and up from 18 percent at year

  3. Current physical activity improves balance control during sensory conflicting conditions in older adults.

    Science.gov (United States)

    Buatois, S; Gauchard, G C; Aubry, C; Benetos, A; Perrin, P

    2007-01-01

    Aging process is characterized by difficulties in ensuring balance control, especially in conditions of reduced or conflicting sensory information, leading to an increased risk of falling. Conversely, the practise of physical activities (PA) has been recognized as a good approach to improve the quality of balance control. This study aimed to investigate the influence of current and/or past PA on balance-related neurosensorial organization in older adults on the maintenance of the upright stance, especially during sensory conflicting situations. Postural control was evaluated by means of the Sensory Organization Test on 130 healthy noninstitutionalized volunteers aged over 65, split into four groups according to the presence or absence of PA before or after retirement. Subjects who practised PA for a long time (Gr1) and subjects who started PA after retirement (Gr2) displayed the best postural performances and better managed sensory conflicting situations compared to subjects who had stopped PA for many years (Gr3) and subjects who had never practised PA (Gr4). Multiple regression analyses revealed that current PA was the major determinant for postural parameters during sensorial conflict compared to age, gender, body mass index and past PA. Regular PA, even when started late in life, allows appropriate reorganization of the different components of postural control during sensory conflicting situations. Indeed, active subjects were more able to compensate for suppressed or perturbed sensory information by an increased usage of another referential and so to correct their posture by adopting a more appropriate balance strategy. Thus, PA counteracts the age-related decline of postural control and could consequently reduce the risk of falling.

  4. Relationship Between Functional Mobility and Balance and Dependency in Activity of Daily Living in Elderly After “Hip Arthroplasty”

    Directory of Open Access Journals (Sweden)

    Gholam Hassan Mirzaie

    2013-01-01

    Full Text Available Objectives: The purpose of this study was to investigate correlation between functional mobility with balance and dependency in activity of daily living in elderly after “hip arthroplasty” (HA and its comparison with healthy subjects. Methods & Materials: The current cross-sectional study was done on 15 patients with age mean and standard deviation (72±9.6 with hip osteoarthritis 6 months after “hip arthroplasty” (HA and 15 healthy subjects with age mean and standard deviation (72.7±1.4 as control group. Patient group was assigned with non- probability convenient sampling and control group selected with matched assignment. Functional mobility measured with Timed Up & Go Test (TUG, functional balance with Functional Reach (FR and Berg Balance Scale (BBS and dependency in activity of daily living measured with Modified Barthel Index (MBI. Pearsons correlation coefficient used for stastistical analysis. Results: Results of this study indicated significantly and stronge correlation between functional mobility and balance and dependency in activity of daily living in patient group (r>0.50. Also medium correlation existed between functional mobility and balance with dependency in activity of daily living in control group (r>0.30. Conclusion: Functional mobility and balance and dependency in activity of daily living in the elderly who had HA showed significant positive correlation. In addition correlation between functional mobility and balance and dependency in activity of daily living in patient group is better and higher than healthy group.

  5. Enabling People with Developmental Disabilities to Actively Follow Simple Instructions and Perform Designated Physical Activities According to Simple Instructions with Nintendo Wii Balance Boards by Controlling Environmental Stimulation

    Science.gov (United States)

    Shih, Ching-Hsiang; Chung, Chiao-Chen; Shih, Ching-Tien; Chen, Ling-Che

    2011-01-01

    The latest researches have adopted software technology turning the Nintendo Wii Balance Board into a high performance standing location detector. This study extended Wii Balance Board functionality to assess whether two people with developmental disabilities would be able to actively perform designated physical activities according to simple…

  6. Innovation and employee injury risk in automotive disassembly operations

    DEFF Research Database (Denmark)

    Neumann, W. Patrick; Winkel, Jørgen; Palmerud, Gunnar

    2018-01-01

    to control injury hazards as part of the development and design process. These cases suggest how failure to manage RSI hazards in the innovation process may allow increases of injury risks that can compromise operational performance. This ‘innovation pitfall’ has implications for operator health...... increased movement speeds and reduced muscular recovery opportunities, implying increased RSI risk. This case study reveals a mechanism by which innovation may increase RSI risks for operators. Managers responsible for engineering innovation should ensure their teams have the tools and mandate necessary......Engineering innovations in car disassembly systems are studied for affects on system operators’ risk of repetitive strain injury (RSI). Objective instrumented measures of injury risk factors with synchronised video-based task analyses were used to examine changes in operators’ RSI risk during...

  7. Maintenance and disassembly considerations for the Technology Demonstration Facility

    International Nuclear Information System (INIS)

    Spampinato, P.T.

    1983-01-01

    The Technology Demonstration Facility (TDF) is a tandem-mirror design concept carried out under the direction of Lawrence Livermore National Laboratory. It was conceived as a near-term device with a mission of developing engineering technology in a D-T fusion environment. Overall maintenance and component disassembly were among the responsibilities of the Fusion Engineering Design Center (FEDC). A configuration evolved that was based on the operational requirements of the components, as well as the requirements for their replacements. Component lifetime estimates were used to estimate the frequency and the number of replacements. In addition, it was determined that the need for remote handling equipment followed within 1.5 years after initial start-up, emphasizing the direct relationship between developing maintenance scenarios/equipment and the device configuration. Many of the scheduled maintenance operations were investigated to first order, and preliminary handling equipment concepts were developed

  8. Introductory Education for Mechanical Engineering by Exercise in Mechanical Disassembly

    Science.gov (United States)

    Matsui, Yoshio; Asakawa, Naoki; Iwamori, Satoru

    An introductory program “Exercise for engineers in mechanical disassembly” is an exercise that ten students of every team disassemble a motor scooter to the components and then assemble again to the initial form in 15 weeks. The purpose of this program is to introduce mechanical engineering by touching the real machine and learning how it is composed from various mechanical parts to the students at the early period after the entrance into the university. Additional short lectures by young teachers and a special lecture by a top engineer in the industry encourage the students to combine the actual machine and the mechanical engineering subjects. Furthermore, various educations such as group leader system, hazard prediction training, parts filing are included in this program. As a result, students recognize the importance of the mechanical engineering study and the way of group working.

  9. Knowledge of damage identification about tensegrities via flexibility disassembly

    Science.gov (United States)

    Jiang, Ge; Feng, Xiaodong; Du, Shigui

    2017-12-01

    Tensegrity structures composing of continuous cables and discrete struts are under tension and compression, respectively. In order to determine the damage extents of tensegrity structures, a new method for tensegrity structural damage identification is presented based on flexibility disassembly. To decompose a tensegrity structural flexibility matrix into the matrix represention of the connectivity between degress-of-freedoms and the diagonal matrix comprising of magnitude informations. Step 1: Calculate perturbation flexibility; Step 2: Compute the flexibility connectivity matrix and perturbation flexibility parameters; Step 3: Calculate the perturbation stiffness parameters. The efficiency of the proposed method is demonstrated by a numeical example comprising of 12 cables and 4 struts with pretensioned. Accurate identification of local damage depends on the availability of good measured data, an accurate and reasonable algorithm.

  10. Sequential phosphorylation of GRASP65 during mitotic Golgi disassembly

    Directory of Open Access Journals (Sweden)

    Danming Tang

    2012-09-01

    GRASP65 phosphorylation during mitosis and dephosphorylation after mitosis are required for Golgi disassembly and reassembly during the cell cycle. At least eight phosphorylation sites on GRASP65 have been identified, but whether they are modified in a coordinated fashion during mitosis is so far unknown. In this study, we raised phospho-specific antibodies that recognize phosphorylated T220/T224, S277 and S376 residues of GRASP65, respectively. Biochemical analysis showed that cdc2 phosphorylates all three sites, while plk1 enhances the phosphorylation. Microscopic studies using these antibodies for double and triple labeling demonstrate sequential phosphorylation and dephosphorylation during the cell cycle. S277 and S376 are phosphorylated from late G2 phase through metaphase until telophase when the new Golgi is reassembled. T220/224 is not modified until prophase, but is highly modified from prometaphase to anaphase. In metaphase, phospho-T220/224 signal localizes on both Golgi haze and mitotic Golgi clusters that represent dispersed Golgi vesicles and Golgi remnants, respectively, while phospho-S277 and S376 labeling is more concentrated on mitotic Golgi clusters. Expression of a phosphorylation-resistant GRASP65 mutant T220A/T224A inhibited mitotic Golgi fragmentation to a much larger extent than the expression of the S277A and S376A mutants. In cytokinesis, T220/224 dephosphorylation occurs prior to that of S277, but after S376. This study provides evidence that GRASP65 is sequentially phosphorylated and dephosphorylated during mitosis at different sites to orchestrate Golgi disassembly and reassembly during cell division, with phosphorylation of the T220/224 site being most critical in the process.

  11. The raw material and waste activity balance in the projected nuclear power of Russia

    International Nuclear Information System (INIS)

    Adamov, E.O.; Ganev, I.Kh.; Lopatkin, A.V.; Muratov, V.G.; Orlov, V.V.

    1997-01-01

    Under discussion is the management of long-lived high-level wastes in the nuclear energy sector of Russia, the development of which on a large scale in the next century is motivated by the need for arresting the increasing consumption of fossil fuels. The prerequisites for the nuclear power growth consists in the design of naturally safe reactors and development of a transmutational nuclear fuel cycle (NFC) technology. The choice of operations in such a cycle and of their quantitative characteristics, is aimed at minimizing the wastes to approach the radiation balance with the natural uranium extracted and put to use. The paper discusses the way the approximation to the balance between the raw material and waste activity is influenced by introduction of the transmutational NFC (in case 2), inclusion of transmutation reactors into the energy mix (case 1), partial disposal of actinide wastes into outer space, and by recycling of protactinium (case 3). It is shown that such a balance can be sustained for a considerable time in cases 2 and 3 or throughout the operation stage of the future nuclear power (case 1). (orig.)

  12. Balancing Act

    Science.gov (United States)

    Part of being an Active, More Powerful You means finding balance in your daily life: taking on the Must-dos and finding time for some Should Dos and Want-to-Dos. Sometimes, emotions and commitments can come into play and upset the balance.

  13. Active tower damping and pitch balancing – design, simulation and field test

    International Nuclear Information System (INIS)

    Duckwitz, Daniel; Shan, Martin

    2014-01-01

    The tower is one of the major components in wind turbines with a contribution to the cost of energy of 8 to 12% [1]. In this overview the load situation of the tower will be described in terms of sources of loads, load components and fatigue contribution. Then two load reduction control schemes are described along with simulation and field test results. Pitch Balancing is described as a method to reduce aerodynamic asymmetry and the resulting fatigue loads. Active Tower Damping is reducing the tower oscillations by applying appropiate pitch angle changes. A field test was conducted on an Areva M5000 wind turbine

  14. Active tower damping and pitch balancing - design, simulation and field test

    Science.gov (United States)

    Duckwitz, Daniel; Shan, Martin

    2014-12-01

    The tower is one of the major components in wind turbines with a contribution to the cost of energy of 8 to 12% [1]. In this overview the load situation of the tower will be described in terms of sources of loads, load components and fatigue contribution. Then two load reduction control schemes are described along with simulation and field test results. Pitch Balancing is described as a method to reduce aerodynamic asymmetry and the resulting fatigue loads. Active Tower Damping is reducing the tower oscillations by applying appropiate pitch angle changes. A field test was conducted on an Areva M5000 wind turbine.

  15. 30 CFR 817.57 - Hydrologic balance: Surface activities in or adjacent to perennial or intermittent streams.

    Science.gov (United States)

    2010-07-01

    ... PERMANENT PROGRAM PERFORMANCE STANDARDS-UNDERGROUND MINING ACTIVITIES § 817.57 Hydrologic balance: Surface... by roads, railroads, conveyors, pipelines, utilities, or similar facilities. You must comply with all...

  16. The Effect of One Period Factitious and True Neurofeedback Training on the Balance Performance of Active Males

    Directory of Open Access Journals (Sweden)

    Amir Hossein Barati

    2015-12-01

    Conclusion: Due to its positive impact on the balance of active males, neurofeedback training can be used as a complementary training program to increase their efficiency of such students in competitions.

  17. A Study of the Effect of Preschool Children's Participation in Sensorimotor Activities on Their Understanding of the Mechanical Equilibrium of a Balance Beam

    Science.gov (United States)

    Hadzigeorgiou, Yannis; Anastasiou, Leonidas; Konsolas, Manos; Prevezanou, Barbara

    2009-01-01

    The purpose of this study was to investigate whether participation in sensorimotor activities by preschool children involving their own bodily balance while walking on a beam over the floor has an effect on their understanding of the mechanical equilibrium of a balance beam. The balance beam consisted of a horizontal stick balancing around its…

  18. Balancing struggles with desired results in everyday activities: strategies for elderly persons with physical disabilities.

    Science.gov (United States)

    Bontje, Peter; Asaba, Eric; Josephsson, Staffan

    2016-03-01

    The number of elderly persons with disabilities needing support with everyday activities increasing in Japan and around the world. Yet, engagement in everyday activities can support the quality of their daily life. Despite research focusing on reported meanings of people's actions, there is still limited knowledge on how engagement in everyday activity is enacted along with the meanings of persons' actions. The aim of the present study was to identify meanings of persons' actions within everyday activities of elderly Japanese with physical disabilities. Five elderly persons with physical disabilities living in the community participated in this study. Data were gathered by 10 participant observations of everyday activities supplemented with 13 unstructured interviews. Narrative analysis was used to identify meanings of persons' actions. The analysis identified an overall plot termed 'balancing struggles with desired results'. This plot illustrated that participants' and other involved individuals balanced problematic situations with finding situations that accommodated their needs. Meanings of these actions were further identified as three complementary strategies. Two of three strategies aimed to mitigate given problems, one by 'acting on a plan to achieve one's goals', the other by 'taking a step in a preferred direction by capitalising on emerging opportunities'. The third strategy focused on avoiding undesirable experiences by 'modifying problematic situations'. In conclusion, these findings call for care and rehabilitation providers' sensitivity to shifting foci of what matters in daily life's situations as well as aligning with persons' skills, resources and perspectives. Accordingly, the judicious and flexible use of these complementary strategies can enhance elderly persons' quality of daily living through everyday activities. © 2015 Nordic College of Caring Science.

  19. The influence of a balanced volume replacement concept on inflammation, endothelial activation, and kidney integrity in elderly cardiac surgery patients.

    Science.gov (United States)

    Boldt, Joachim; Suttner, Stephan; Brosch, Christian; Lehmann, Andreas; Röhm, Kerstin; Mengistu, Andinet

    2009-03-01

    A balanced fluid replacement strategy appears to be promising for correcting hypovolemia. The benefits of a balanced fluid replacement regimen were studied in elderly cardiac surgery patients. In a randomized clinical trial, 50 patients aged >75 years undergoing cardiac surgery received a balanced 6% HES 130/0.42 plus a balanced crystalloid solution (n = 25) or a non-balanced HES in saline plus saline solution (n = 25) to keep pulmonary capillary wedge pressure/central venous pressure between 12-14 mmHg. Acid-base status, inflammation, endothelial activation (soluble intercellular adhesion molecule-1, kidney integrity (kidney-specific proteins glutathione transferase-alpha; neutrophil gelatinase-associated lipocalin) were studied after induction of anesthesia, 5 h after surgery, 1 and 2 days thereafter. Serum creatinine (sCr) was measured approximately 60 days after discharge. A total of 2,750 +/- 640 mL of balanced and 2,820 +/- 550 mL of unbalanced HES were given until the second POD. Base excess (BE) was significantly reduced in the unbalanced (from +1.21 +/- 0.3 to -4.39 +/- 1.0 mmol L(-1) 5 h after surgery; P volume replacement strategy including a balanced HES and a balanced crystalloid solution resulted in moderate beneficial effects on acid-base status, inflammation, endothelial activation, and kidney integrity compared to a conventional unbalanced volume replacement regimen.

  20. A methodological approach for designing and sequencing product families in Reconfigurable Disassembly Systems

    Directory of Open Access Journals (Sweden)

    Ignacio Eguia

    2011-10-01

    Full Text Available Purpose: A Reconfigurable Disassembly System (RDS represents a new paradigm of automated disassembly system that uses reconfigurable manufacturing technology for fast adaptation to changes in the quantity and mix of products to disassemble. This paper deals with a methodology for designing and sequencing product families in RDS. Design/methodology/approach: The methodology is developed in a two-phase approach, where products are first grouped into families and then families are sequenced through the RDS, computing the required machines and modules configuration for each family. Products are grouped into families based on their common features using a Hierarchical Clustering Algorithm. The optimal sequence of the product families is calculated using a Mixed-Integer Linear Programming model minimizing reconfigurability and operational costs. Findings: This paper is focused to enable reconfigurable manufacturing technologies to attain some degree of adaptability during disassembly automation design using modular machine tools. Research limitations/implications: The MILP model proposed for the second phase is similar to the well-known Travelling Salesman Problem (TSP and therefore its complexity grows exponentially with the number of products to disassemble. In real-world problems, which a higher number of products, it may be advisable to solve the model approximately with heuristics. Practical implications: The importance of industrial recycling and remanufacturing is growing due to increasing environmental and economic pressures. Disassembly is an important part of remanufacturing systems for reuse and recycling purposes. Automatic disassembly techniques have a growing number of applications in the area of electronics, aerospace, construction and industrial equipment. In this paper, a design and scheduling approach is proposed to apply in this area. Originality/value: This paper presents a new concept called Reconfigurable Disassembly System

  1. A balancing act of the brain: activations and deactivations driven by cognitive load.

    Science.gov (United States)

    Arsalidou, Marie; Pascual-Leone, Juan; Johnson, Janice; Morris, Drew; Taylor, Margot J

    2013-05-01

    The majority of neuroimaging studies focus on brain activity during performance of cognitive tasks; however, some studies focus on brain areas that activate in the absence of a task. Despite the surge of research comparing these contrasted areas of brain function, their interrelation is not well understood. We systematically manipulated cognitive load in a working memory task to examine concurrently the relation between activity elicited by the task versus activity during control conditions. We presented adults with six levels of task demand, and compared those with three conditions without a task. Using whole-brain analysis, we found positive linear relations between cortical activity and task difficulty in areas including middle frontal gyrus and dorsal cingulate; negative linear relations were found in medial frontal gyrus and posterior cingulate. These findings demonstrated balancing of activation patterns between two mental processes, which were both modulated by task difficulty. Frontal areas followed a graded pattern more closely than other regions. These data also showed that working memory has limited capacity in adults: an upper bound of seven items and a lower bound of four items. Overall, working memory and default-mode processes, when studied concurrently, reveal mutually competing activation patterns.

  2. Design performances and chemistry program supporting the FA3 /UKEPRTM activity management: experience and modeling balance

    International Nuclear Information System (INIS)

    Tigeras, Arancha; Clinard, Marie-Helene; Chahma, Farah; Jolivet, Patrick; Bremnes, Oystein; Bachet, Martin

    2012-09-01

    EPR TM reactor accounts with an evolutionary design that provides the appropriate features to ensure the safety implementation of different chemistry and radiochemistry options. ALARP considerations have been taken into account by EDF-AREVA for making decisions relating to the activity management in the primary circuit of Flamanville 3-EPR TM and UK-EPR TM reactors. The water chemistry and radiochemistry concept implemented in FA3-EPR TM and UK-EPR TM reactors is the result of an exhaustive selection process based on the balance between the theoretical developments, the laboratory tests and the NPP experience concerning the diverse areas associated with: - The source term identification and characterization: The understanding of the origin and behavior of fission products/actinides, corrosion products and activation products constitutes the essential support for the selection of suitable parameters and criteria to monitor the system integrity, the tramp-uranium and radiation build-up and the discharges to the environment. - The source term quantification: The balance between the baseline data from PWR forerunner reactors and the assessments performed by modeling constitutes the major demonstration of the source term accuracy. This approach ensures that activity risks are understood and can be managed with the EPR TM design options. - The EPR TM design options evaluation: The sensitivity analysis results show the influence of the fuel management, the material choice and the chemistry conditioning on several domains such as the activity coolant and the fuel/ex-core crud management. EDF-AREVA demonstrates by means of this process that the design, sizing and chemistry conditioning of EPR TM reactor primary circuit are adapted to guarantee the correct activity management. The methodology developed, based on qualitative and quantitative assessments, intends to propose to the Nuclear Industry several alternatives for evaluating and/or improving the compliance with

  3. The number of supports does not modify the electrical cortical activity during balance tasks.

    Directory of Open Access Journals (Sweden)

    Daniel Collado-Mateo

    2017-08-01

    Full Text Available Aims: The objective was to evaluate the electrical cortical activity during two static and two dynamic tasks, comparing between tasks with single support tasks and tasks with two feet on the platform. Settings and Design: Sixteen young males participated in this cross-sectional study. Methods and Material: Electrical cortical activity was assessed using the Enobio device. Two static and two dynamic tasks were performed, all of them on the Biodex Balance System device. Statistical analysis used: Mean power spectrum for the Alpha band was analyzed. The Wilcoxon signed rank test was used to compare tasks with one single support and tasks with the two feet on the platform. Results: No significant difference was observed when comparing the balance tasks. Conclusions: The number of supports did not significantly modify the EEG signal in the alpha band. However, cognitive demands in the single support dynamic task seemed to be somewhat higher compared with the rest of the tasks. These results may be relevant to design future programs based on dual task.

  4. Life Prediction of Large Lithium-Ion Battery Packs with Active and Passive Balancing

    Energy Technology Data Exchange (ETDEWEB)

    Shi, Ying [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Smith, Kandler A [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Zane, Regan [Utah State University; Anderson, Dyche [Ford Motor Company

    2017-07-03

    Lithium-ion battery packs take a major part of large-scale stationary energy storage systems. One challenge in reducing battery pack cost is to reduce pack size without compromising pack service performance and lifespan. Prognostic life model can be a powerful tool to handle the state of health (SOH) estimate and enable active life balancing strategy to reduce cell imbalance and extend pack life. This work proposed a life model using both empirical and physical-based approaches. The life model described the compounding effect of different degradations on the entire cell with an empirical model. Then its lower-level submodels considered the complex physical links between testing statistics (state of charge level, C-rate level, duty cycles, etc.) and the degradation reaction rates with respect to specific aging mechanisms. The hybrid approach made the life model generic, robust and stable regardless of battery chemistry and application usage. The model was validated with a custom pack with both passive and active balancing systems implemented, which created four different aging paths in the pack. The life model successfully captured the aging trajectories of all four paths. The life model prediction errors on capacity fade and resistance growth were within +/-3% and +/-5% of the experiment measurements.

  5. Development of remote disassembly technology for liquid-metal reactor (LMR) fuel

    International Nuclear Information System (INIS)

    Bradley, E.C.; Evans, J.H.; Metz, C.F. III; Weil, B.S.

    1990-01-01

    A major objective of the Consolidated Fuel Reprocessing Program (CFRP) is to develop equipment and demonstrate technology to reprocess fast breeder reactor fuel. Experimental work on fuel disassembly cutting methods began in the 1970s. High-power laser cutting was selected as the preferred cutting method for fuel disassembly. Remotely operated development equipment was designed, fabricated, installed, and tested at Oak Ridge National Laboratory (ORNL). Development testing included remote automatic operation, remote maintenance testing, and laser cutting process development. This paper summarizes the development work performed at ORNL on remote fuel disassembly. 2 refs., 1 fig

  6. AGR-3/4 Irradiation Test Train Disassembly and Component Metrology First Look Report

    Energy Technology Data Exchange (ETDEWEB)

    Stempien, John Dennis [Idaho National Lab. (INL), Idaho Falls, ID (United States); Rice, Francine Joyce [Idaho National Lab. (INL), Idaho Falls, ID (United States); Harp, Jason Michael [Idaho National Lab. (INL), Idaho Falls, ID (United States); Winston, Philip Lon [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-09-01

    The AGR-3/4 experiment was designed to study fission product transport within graphitic matrix material and nuclear-grade graphite. To this end, this experiment consisted of 12 capsules, each fueled with 4 compacts containing UCO TRISO particles as driver fuel and 20 UCO designed-to-fail (DTF) fuel particles in each compact. The DTF fuel was fabricated with a thin pyrocarbon layer which was intended to fail during irradiation and provide a source of fission products. These fission products could then migrate through the compact and into the surrounding concentric rings of graphitic matrix material and/or nuclear graphite. Through post-irradiation examination (PIE) of the rings (including physical sampling and gamma scanning) fission product concentration profiles within the rings can be determined. These data can be used to elucidate fission product transport parameters (e.g. diffusion coefficients within the test materials) which will be used to inform and refine models of fission product transport. After irradiation in the Advanced Test Reactor (ATR) had been completed in April 2014, the AGR-3/4 experiment was shipped to the Hot Fuel Examination Facility (HFEF) at the Materials and Fuels Complex (MFC) for inspection, disassembly, and metrology. The AGR-3/4 test train was received at MFC in two separate shipments between February and April 2015. Visual examinations of the test train exterior did not indicate dimensional distortion, and only two small discolored areas were observed at the bottom of Capsules 8 and 9. No corresponding discoloration was found on the inside of these capsules, however. Prior to disassembly, the two test train sections were subject to analysis via the Precision Gamma Scanner (PGS), which did not indicate that any gross fuel relocation had occurred. A series of specialized tools (including clamps, cutters, and drills) had been designed and fabricated in order to carry out test train disassembly and recovery of capsule components (graphite

  7. AGR-3/4 Irradiation Test Train Disassembly and Component Metrology First Look Report

    Energy Technology Data Exchange (ETDEWEB)

    Stempien, John Dennis [Idaho National Lab. (INL), Idaho Falls, ID (United States); Rice, Francine Joyce [Idaho National Lab. (INL), Idaho Falls, ID (United States); Harp, Jason Michael [Idaho National Lab. (INL), Idaho Falls, ID (United States); Winston, Philip Lon [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-03-01

    The AGR-3/4 experiment was designed to study fission product transport within graphitic matrix material and nuclear-grade graphite. To this end, this experiment consisted of 12 capsules, each fueled with 4 compacts containing UCO TRISO particles as driver fuel and 20 UCO designed-to-fail (DTF) fuel particles in each compact. The DTF fuel was fabricated with a thin pyrocarbon layer which was intended to fail during irradiation and provide a source of fission products. These fission products could then migrate through the compact and into the surrounding concentric rings of graphitic matrix material and/or nuclear graphite. Through post-irradiation examination (PIE) of the rings (including physical sampling and gamma scanning) fission product concentration profiles within the rings can be determined. These data can be used to elucidate fission product transport parameters (e.g. diffusion coefficients within the test materials) which will be used to inform and refine models of fission product transport. After irradiation in the Advanced Test Reactor (ATR) had been completed in April 2014, the AGR-3/4 experiment was shipped to the Hot Fuel Examination Facility (HFEF) at the Materials and Fuels Complex (MFC) for inspection, disassembly, and metrology. The AGR-3/4 test train was received at MFC in two separate shipments between February and April 2015. Visual examinations of the test train exterior did not indicate dimensional distortion, and only two small discolored areas were observed at the bottom of Capsules 8 and 9. No corresponding discoloration was found on the inside of these capsules, however. Prior to disassembly, the two test train sections were subject to analysis via the Precision Gamma Scanner (PGS), which did not indicate that any gross fuel relocation had occurred. A series of specialized tools (including clamps, cutters, and drills) had been designed and fabricated in order to carry out test train disassembly and recovery of capsule components (graphite

  8. The effects of cognitive activity combined with active extremity exercise on balance, walking activity, memory level and quality of life of an older adult sample with dementia.

    Science.gov (United States)

    Yoon, Jung Eun; Lee, Suk Min; Lim, Hee Sung; Kim, Tae Hoon; Jeon, Ji Kyeng; Mun, Mee Hyang

    2013-12-01

    [Purpose] The purpose of this study was to compare the effectiveness of cognitive activity combined with active physical exercise for a sample of older adults with dementia. [Subjects] A convenience sample of 30 patients with dementia (Mini-Mental State Examination score between 16 and 23) was used. Participants were randomly allocated to one of two groups: cognitive activity combined with physical exercise CAE, n=11), and only cognitive activity CA, n=9). [Methods] Both groups participated in a therapeutic exercise program for 30 minutes, three days a week for 12 weeks. The CAE group performed an additional exercise for 30 minutes a day, three days a week for 12 weeks. A Wii Balance Board (WBB, Nintendo, Japan) was used to evaluate postural sway as an assessment of balance. The Berg Balance Scale (BBS) and Modified Falls Efficacy Scale (MFES) were used to assess dynamic balance abilities. The Timed Up-and-Go test (TUG) was used to assess gait, and the Digit Span Test (DST) and 7 Minute Screening Test (7MST) were used to measure memory performance. The Mini-Mental Status Exam-Korean version (MMSE-K), Kenny Self-Care Evaluation (KSCE), and Short Geriatric Depression Scale (GDS) were used to assess quality of life (QOL). [Results] There were significant beneficial effects of the therapeutic program on balance (velocity in EOWB, path length in ECNB, BBS, and MMFE), QOL (MMSE-KC, GDS, KSCE), and memory performance (DSB) in the CAE group compared to CA group, and between pre-test and post-test. [Conclusion] A 12-week CAE program resulted in improvements in balance, memory and QOL. Therefore, some older adults with dementia have the ability to acquire effective skills relevant to daily living.

  9. Fuel feeds function: Energy balance and bovine peripheral blood mononuclear cell activation.

    Science.gov (United States)

    Schwarm, A; Viergutz, T; Kuhla, B; Hammon, H M; Schweigel-Röntgen, M

    2013-01-01

    A general phenomenon in peripartum mammals is the breakdown of (acquired) immunity. The incidence of parasite load, disease and inflammation often rise during the specific energetically demanding time of pregnancy and lactation. In this period, blood leukocytes display decreased DNA synthesis in response to mitogens in vitro. Leukocyte activation, the phase of the cell cycle preceding the DNA synthetic phase has hardly been investigated, but the few studies suggest that leukocyte activation may also be impaired by the limited energy/nutrient availability. Leukocyte activation is characterized by manifold processes, thus, we used the cellular oxygen consumption rate (OCR) as a measure of ATP turnover to support all these processes. We hypothesized that the activation of peripheral blood mononuclear cells (PBMC) - in terms of oxygen consumed over basal levels after in vitro stimulation - is altered by energy balance around parturition. We studied peripartum high-yielding dairy cows because they undergo substantial fluctuations in energy intake, energy output and body fat mass. We established a fluorescence-based test strategy allowing for long-term (≥24h) quantification of O(2)-consumption and studied the peripartum period from 5 weeks ante partum to 5 weeks postpartum. In addition, we determined cellular lactate production, DNA/RNA synthesis and cell size and zoo-technical parameters such as animal energy intake and milk yield were assessed, as well as selected plasma parameters, e.g. glucose concentration. The basal OCR of PBMC from pregnant, non-lactating cows (n=6, -5 weeks ante partum) was 1.19±0.15 nmol min(-1) (10(7)cells)(-1) and increased to maximum levels of 2.54±0.49 nmol min(-1) (10(7)cells)(-1) in phytohemagglutinin (PHA)-stimulated PBMC. The basal OCR did not change over the peripartum period. Whereas the activation indices, herein defined as the PHA-induced 24h-increase of OCR above baseline, amounted to 1.1±0.3, 4.2±0.3, 4.1±1.1, 2.1±0.3, and

  10. Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation.

    Science.gov (United States)

    Garrison, Allison M; Parrott, Jennifer M; Tuñon, Arnulfo; Delgado, Jennifer; Redus, Laney; O'Connor, Jason C

    2018-08-01

    Chronic stress or inflammation increases tryptophan metabolism along the kynurenine pathway (KP), and the generation of neuroactive kynurenine metabolites contributes to subsequent depressive-like behaviors. Microglia regulate KP balance by preferentially producing oxidative metabolites, including quinolinic acid. Research has focused on the interplay between cytokines and HPA axis-derived corticosteroids in regulating microglial activity and effects of KP metabolites directly on neurons; however, the potential role that KP metabolites have directly on microglial activity is unknown. Here, murine microglia were stimulated with lipopolysaccharide(LPS). After 6 h, mRNA expression of interleukin(IL)-1β, IL-6, tumor necrosis factor(TNF)-α and inducible nitric oxide synthase(iNOS) was dose-dependently increased along with the rate-limiting enzymes for oxidative KP metabolism, indoleamine-2,3-dioxygenase(IDO)-1 and kynurenine 3-monooxygenase(KMO). By 24 h post-LPS, kynurenine and quinolinic acid in the media was elevated. Inhibiting KMO with Ro 61-8048 during LPS challenge attenuated extracellular nitrite accumulation and expression of KMO and TNF-α in response to LPS. Similarly, primary microglia isolated from KMO -/- mice exhibited a significantly reduced pro-inflammatory response to LPS compared to WT controls. To determine whether the substrate (kynurenine) or end product (quinolinic acid) of KMO-dependent metabolism modulates the LPS response, microglia were treated with increasing concentrations of L-kynurenine or quinolinic acid in combination with LPS or saline. Interestingly, quinolinic acid did not impact the microglial LPS response. However, L-kynurenine had dose-dependent inhibitory effect on the LPS response. These data are the first to show an anti-inflammatory effect of KMO inhibition on microglia during immune challenge and suggest that KP metabolic balance may play a direct role in regulating microglia activity. Published by Elsevier Ltd.

  11. Active influence in dynamical models of structural balance in social networks

    Science.gov (United States)

    Summers, Tyler H.; Shames, Iman

    2013-07-01

    We consider a nonlinear dynamical system on a signed graph, which can be interpreted as a mathematical model of social networks in which the links can have both positive and negative connotations. In accordance with a concept from social psychology called structural balance, the negative links play a key role in both the structure and dynamics of the network. Recent research has shown that in a nonlinear dynamical system modeling the time evolution of “friendliness levels” in the network, two opposing factions emerge from almost any initial condition. Here we study active external influence in this dynamical model and show that any agent in the network can achieve any desired structurally balanced state from any initial condition by perturbing its own local friendliness levels. Based on this result, we also introduce a new network centrality measure for signed networks. The results are illustrated in an international-relations network using United Nations voting record data from 1946 to 2008 to estimate friendliness levels amongst various countries.

  12. Dopamine D1 receptor activation maintains motor coordination and balance in rats.

    Science.gov (United States)

    Avila-Luna, Alberto; Gálvez-Rosas, Arturo; Durand-Rivera, Alfredo; Ramos-Languren, Laura-Elisa; Ríos, Camilo; Arias-Montaño, José-Antonio; Bueno-Nava, Antonio

    2018-02-01

    Dopamine (DA) modulates motor coordination, and its depletion, as in Parkinson's disease, produces motor impairment. The basal ganglia, cerebellum and cerebral cortex are interconnected, have functional roles in motor coordination, and possess dopamine D 1 receptors (D 1 Rs), which are expressed at a particularly high density in the basal ganglia. In this study, we examined whether the activation of D 1 Rs modulates motor coordination and balance in the rat using a beam-walking test that has previously been used to detect motor coordination deficits. The systemic administration of the D 1 R agonist SKF-38393 at 2, 3, or 4 mg/kg did not alter the beam-walking scores, but the subsequent administration of the D 1 R antagonist SCH-23390 at 1 mg/kg did produce deficits in motor coordination, which were reversed by the full agonist SKF-82958. The co-administration of SKF-38393 and SCH-23390 did not alter the beam-walking scores compared with the control group, but significantly prevented the increase in beam-walking scores induced by SCH-23390. The effect of the D 1 R agonist to prevent and reverse the effect of the D 1 R antagonist in beam-walking scores is an indicator that the function of D 1 Rs is necessary to maintain motor coordination and balance in rats. Our results support that D 1 Rs mediate the SCH-23390-induced deficit in motor coordination.

  13. Disassembly Properties of Cementitious Finish Joints Using an Induction Heating Method

    Science.gov (United States)

    Ahn, Jaecheol; Noguchi, Takafumi; Kitagaki, Ryoma

    2015-01-01

    Efficient maintenance and upgrading of a building during its lifecycle are difficult because a cementitious finish uses materials and parts with low disassembly properties. Additionally, the reuse and recycling processes during building demolition also present numerous problems from the perspective of environmental technology. In this study, an induction heating (IH) method was used to disassemble cementitious finish joints, which are widely used to join building members and materials. The IH rapidly and selectively heated and weakened these joints. The temperature elevation characteristics of the cementitious joint materials were measured as a function of several resistor types, including wire meshes and punching metals, which are usually used for cementitious finishing. The disassembly properties were evaluated through various tests using conductive resistors in cementitious joints such as mortar. When steel fiber, punching metal, and wire mesh were used as conductive resistors, the cementitious modifiers could be weakened within 30 s. Cementitious joints with conductive resistors also showed complete disassembly with little residual bond strength.

  14. Direct measurement of conformational strain energy in protofilaments curling outward from disassembling microtubule tips.

    Science.gov (United States)

    Driver, Jonathan W; Geyer, Elisabeth A; Bailey, Megan E; Rice, Luke M; Asbury, Charles L

    2017-06-19

    Disassembling microtubules can generate movement independently of motor enzymes, especially at kinetochores where they drive chromosome motility. A popular explanation is the 'conformational wave' model, in which protofilaments pull on the kinetochore as they curl outward from a disassembling tip. But whether protofilaments can work efficiently via this spring-like mechanism has been unclear. By modifying a previous assay to use recombinant tubulin and feedback-controlled laser trapping, we directly demonstrate the spring-like elasticity of curling protofilaments. Measuring their mechanical work output suggests they carry ~25% of the energy of GTP hydrolysis as bending strain, enabling them to drive movement with efficiency similar to conventional motors. Surprisingly, a β-tubulin mutant that dramatically slows disassembly has no effect on work output, indicating an uncoupling of disassembly speed from protofilament strain. These results show the wave mechanism can make a major contribution to kinetochore motility and establish a direct approach for measuring tubulin mechano-chemistry.

  15. Disassembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients

    Directory of Open Access Journals (Sweden)

    Adler Charles

    2009-07-01

    Full Text Available Abstract Correction to Nural H, He P, Beach T, Sue L, Xia W, Shen Y. Disassembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients Molecular Neurodegeneration 2009, 4:23.

  16. Alpha Decontamination and Disassembly Pilot Facility. Final report

    International Nuclear Information System (INIS)

    Daugherty, B.A.; Clark, H.E.

    1985-04-01

    The Alpha Decontamination and Disassembly (AD and D) Pilot Facility was built to develop and demonstrate a reference process for the decontamination and size reduction of noncombustible transuranic (TRU) waste. The goals of the reference process were to remove >99% of the surface contamination to the high-level waste tanks, and to achieve volume reduction factors greater than 15:1. Preliminary bench-scale decontamination work was accomplished at Savannah River Laboratory (SRL), establishing a reference decontamination process. Initially, the pilot facility did not achieve the decontamination goals. As the program continued, and modifications to the process were made, coupon analysis idicated that 99% of the surface contamination was removed to the high-level drain system. Prior to the AD and D Pilot Facility, no size reduction work had been done at SRL. Several other Department of Energy (DOE) facilities were experimenting with plasma arc torches for size reduction work. Their methods were employed in the AD and D hot cell with moderate success. The experimental work concluded with recommendations for further testing of other size reduction techniques. 11 figs., 6 tabs

  17. Putting Physical Activity While Experiencing Low Back Pain in Context: Balancing the Risks and Benefits.

    Science.gov (United States)

    Darlow, Ben; Perry, Meredith; Dean, Sarah; Mathieson, Fiona; Baxter, G David; Dowell, Anthony

    2016-02-01

    To analyze attitudes and beliefs about movement and physical activity in people with low back pain (LBP) and compare these beliefs between people with acute and chronic LBP. Qualitative inductive analysis of data collected via face-to-face semistructured interviews. Interviews were audio-recorded and transcribed verbatim. Participants were purposively recruited from 1 region of New Zealand. Persons with LBP (N=23), consisting of individuals with acute LBP (3mo; n=11). Not applicable. Themes that emerged from participant interview transcripts using analysis based on Interpretative Description. Participants with acute and chronic LBP made judgments about physical activity and rest using the same conceptual model. Concerns about creating more pain, tissue damage, or impairment influenced the physical activity judgments of most participants with acute and chronic LBP. These perceived risks were balanced against the perceived benefits, the most important of which were psychological or social rather than physical. Judgments made by those with acute and chronic LBP were context dependent and influenced by the nature and duration of pain, the type of physical activity, the importance of the activity, and the participant's previous experience. Participants with acute pain who had not experienced back pain previously often expressed more uncertainty, whereas those with chronic LBP appeared to have developed cognitive rules that determined physical activity decisions. Exploring the perceived risks, benefits, and contextual factors that influence decisions about physical activity and rest may help clinicians to understand the behavior of patients with acute and chronic LBP. Clinicians may best support their patients to engage in physical activity by providing an informed assessment of risks and an explanation about the range of potential benefits. Copyright © 2016 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  18. Spent-fuel disassembly and canning programs at the Barnwell Nuclear Fuel Plant (BNFP)

    International Nuclear Information System (INIS)

    Townes, G.A.

    1980-02-01

    Doubling pool storage and tripling truck cask shipping capability appear feasible based on preliminary development work performed at the BNFP. This would be accomplished by disassembly of the fuel assembly and canning of the fuel pins. The dry, remote disassembly and canning in the headend cells offer adequate rates, easily controlled operator exposure, and visual inspection of the fuel pins and operations through shielded windows

  19. Exogenous vs. endogenous attention: Shifting the balance of fronto-parietal activity.

    Science.gov (United States)

    Meyer, Kristin N; Du, Feng; Parks, Emily; Hopfinger, Joseph B

    2018-03-01

    Despite behavioral and electrophysiological evidence for dissociations between endogenous (voluntary) and exogenous (reflexive) attention, fMRI results have yet to consistently and clearly differentiate neural activation patterns between these two types of attention. This study specifically aimed to determine whether activity in the dorsal fronto-parietal network differed between endogenous and exogenous conditions. Participants performed a visual discrimination task in endogenous and exogenous attention conditions while undergoing fMRI scanning. Analyses revealed robust and bilateral activation throughout the dorsal fronto-parietal network for each condition, in line with many previous results. In order to investigate possible differences in the balance of neural activity within this network with greater sensitivity, a priori regions of interest (ROIs) were selected for analysis, centered on the frontal eye fields (FEF) and intraparietal sulcus (IPS) regions identified in previous studies. The results revealed a significant interaction between region, condition, and hemisphere. Specifically, in the left hemisphere, frontal areas were more active than parietal areas, but only during endogenous attention. Activity in the right hemisphere, in contrast, remained relatively consistent for these regions across conditions. Analysis of this activity over time indicates that this left-hemispheric regional imbalance is present within the FEF early, at 3-6.5 s post-stimulus presentation, whereas a regional imbalance in the exogenous condition is not evident until 6.5-8 s post-stimulus presentation. Overall, our results provide new evidence that although the dorsal fronto-parietal network is indeed associated with both types of attentional orienting, regions of the network are differentially engaged over time and across hemispheres depending on the type of attention. Copyright © 2018 Elsevier Ltd. All rights reserved.

  20. The effect of sudden server breakdown on the performance of a disassembly line

    Science.gov (United States)

    Udomsawat, Gun; Gupta, Surendra M.

    2005-11-01

    Product and material recovery relies on the disassembly process to separate target components or materials from the end-of-life (EOL) products. Disassembly line is especially effective when products in large quantity are disassembled. Unlike an assembly line, a disassembly line is more complex and is subjected to numerous uncertainties including stochastic and multi-level arrivals of component demands, stochastic arrival times for EOL products, and process interruption due to equipment failure. These factors seriously impair the control mechanism in the disassembly line. A common production control mechanism is the traditional push system (TPS). TPS responds to the aforementioned complications by carrying substantial amounts of inventories. An alternative control mechanism is a newly developed multi-kanban pull system (MKS) that relies on dynamic routing of kanbans, which tends to minimize the system's inventories while maintaining demand serviceability. In this paper we explore the impact of sudden breakdown of server on the performance of a disassembly line. We compare the overall performances of the TPS and MKS by considering two scenarios. We present the solution procedure and results for these cases.

  1. Studies of fast reactor disassembly using a Bethe-Tait computer code

    International Nuclear Information System (INIS)

    Ludwig, J.C.

    1978-10-01

    The advantages of the fast reactor are given and the general design outlined. Loss of Flow and Transient Overpower faults are possible; the potential consequences of such incidents are analysed using a deterministic approach. The course of an incident is split into several stages; of these only predisassembly and disassembly are considered. Predisassembly computer codes are described in general, and several particular codes are examined in more detail, based on a literature survey. The results and implications of disassembly calculations using the code EXTRA are presented. Here, the effects of several factors, such as the presence of retained fission gases and possible restraints on fuel motion, are investigated. Some comparisons are made with published results from the VENUS-II disassembly code. A general conclusion is that under some circumstances, the yield predicted during disassembly is relatively insensitive to modelling assumptions, and a simple code such as EXTRA may prove adequate if explicit core displacements are not required. A major factor in determining the yield of the disassembly phase is confirmed as being the rate of reactivity insertion during disassembly, as predicted by a predisassembly code. (U.K.)

  2. Out pile test of a disassembly tool for the intermediate examination of nuclear fuel rods

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Jintae; Joung, Chang-Young; Ahn, Sung-Ho; Yang, Tae-Ho; Jang, Seo-Yoon; Park, Seung-Jae [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    The two fuel rod assemblies are assembled with a bayonet coupler, and the non-instrumented fuel rod assembly can be disassembled for intermediate examination. A tool to disassemble the non-instrumented fuel rod assembly from the test rig was developed, and steel wires are connected to the tool to operate release function. In this study, an assembly plug with a quick plug typed bayonet coupler and the accompanying disassembly tool was designed to prevent the interference problem. A test rig mockup was fabricated, and performance test was carried out in the laboratory. And, the out pile test was also carried out in the single channel test loop established in the KAERI. In this study, a modified coupler design to disassemble the non-instrumented fuel rod assembly from the test rig for the intermediate examination was suggested to solve interference problem of previous design. The performance of the modified design was verified by test mockup fabricated with the modified coupler design and accompanied disassembly tool design. Finally, out pile test was carried out in the single channel test loop in the KAERI, and the test rig and the disassembly tool showed good performance and reliability. The developed technique will be useful to the periodic intermediate examination of nuclear fuel rods.

  3. Out pile test of a disassembly tool for the intermediate examination of nuclear fuel rods

    International Nuclear Information System (INIS)

    Hong, Jintae; Joung, Chang-Young; Ahn, Sung-Ho; Yang, Tae-Ho; Jang, Seo-Yoon; Park, Seung-Jae

    2016-01-01

    The two fuel rod assemblies are assembled with a bayonet coupler, and the non-instrumented fuel rod assembly can be disassembled for intermediate examination. A tool to disassemble the non-instrumented fuel rod assembly from the test rig was developed, and steel wires are connected to the tool to operate release function. In this study, an assembly plug with a quick plug typed bayonet coupler and the accompanying disassembly tool was designed to prevent the interference problem. A test rig mockup was fabricated, and performance test was carried out in the laboratory. And, the out pile test was also carried out in the single channel test loop established in the KAERI. In this study, a modified coupler design to disassemble the non-instrumented fuel rod assembly from the test rig for the intermediate examination was suggested to solve interference problem of previous design. The performance of the modified design was verified by test mockup fabricated with the modified coupler design and accompanied disassembly tool design. Finally, out pile test was carried out in the single channel test loop in the KAERI, and the test rig and the disassembly tool showed good performance and reliability. The developed technique will be useful to the periodic intermediate examination of nuclear fuel rods

  4. Effects of reactive oxygen species on cellular wall disassembly of banana fruit during ripening.

    Science.gov (United States)

    Cheng, Guiping; Duan, Xuewu; Shi, John; Lu, Wangjin; Luo, Yunbo; Jiang, Weibo; Jiang, Yueming

    2008-07-15

    Fruit softening is generally attributed to cell wall disassembly. Experiments were conducted to investigate effects of various reactive oxygen species (ROS) on in vitro cellular wall disassembly of harvested banana fruit. The alcohol-extracted insoluble residue (AEIR) was obtained from the pulp tissues of banana fruit at various ripening stages and then used to examine the disassembly of cellular wall polysaccharides in the presence of superoxide anion (O2(-)), hydrogen peroxide (H2O2) or hydroxyl radical (OH) and their scavengers. The presence of OH accelerated significantly disassembly of cellular wall polysaccharides in terms of the increase in contents of total sugars released and uronic acid, and the decrease in molecular mass of soluble polysaccharides, using gel permeation chromatography. However, the treatment with H2O2 or O2(-) showed no significant effect on the disassembly of cellular wall polysaccharides. Furthermore, the degradation of the de-esterified AEIR was more susceptible to OH attack than the esterified AEIR. In addition, the effect of OH could be inhibited in the presence of OH scavenger. This study suggests that disassembly of cellular wall polysaccharides could be initiated by OH as the solublisation of the polysaccharides increased, which, in turn, accelerated fruit softening. Copyright © 2008 Elsevier Ltd. All rights reserved.

  5. Persistent organic pollutants (POPs) in the conventional activated sludge treatment process: fate and mass balance

    International Nuclear Information System (INIS)

    Katsoyiannis, Athanasios; Samara, Constantini

    2005-01-01

    The fate and the mass balance of persistent organic pollutants (POPs) during the conventional activated sludge treatment process were investigated in the wastewater treatment plant of the city of Thessaloniki, northern Greece. The POPs of interest were 7 polychlorinated biphenyls and 19 organochlorine pesticides. Target compounds were determined at six different points across the treatment system: the influent, the effluent of the primary sedimentation tank, the effluent of the secondary sedimentation tank, the primary sludge, the activated sludge from the recirculation stream, and the digested/dewatered sludge. The distribution of POPs between the dissolved and the adsorbed phases of wastewater and sludge was investigated. A good linear relationship between the distribution coefficients, K d , and the octanol-water partition coefficients, K ow , of the solutes was observed only in raw wastewater, suggesting that other factors affect the phase distribution of organic compounds in treated wastewater. For all POPs, a significant increase in partitioning with a decreasing solids concentration was observed, revealing an effect from non-settling microparticles remaining in the 'dissolved' phase during the separation procedure. A good linear relationship was also revealed between logK d and the dissolved organic carbon (DOC) content of wastewater, suggesting that DOC favors the advective transport of POPs in the dissolved phase. Almost all POPs showed good mass balance agreements at both the primary and the secondary treatment. The losses observed for some species could be attributed to biodegradation/biotransformation rather than volatilization. The relative distribution between the treated effluent and the waste sludge streams varied largely among different compounds, with p-p'-DDE being highly accumulated in the waste sludge (98%) but almost 60% of α-HCH remaining in the treated effluent

  6. A pilot study on the influence of exercising on unstable training machine on balance control and trunk muscles activity.

    Science.gov (United States)

    Domeika, Aurelijus; Aleknaite-Dambrauskiene, Ieva; Poskaitis, Vytautas; Zaveckas, Vidmantas; Grigas, Vytautas; Zvironiene, Ausra

    2018-05-16

    The main position of the working population is becoming sitting. Immobile prolonged sedentary time may cause negative effects including reduced intervertebral discs nutrition. Main ways of mitigating them are regular position changes and exercising. To evaluate influence of the short term training on unstable training machine on balance control and trunk muscles activity in patients with lower back pain. Participants (n=16) experiencing lower back pain were trained on an unstable sculling machine "Rehabili". Their balance tested by (Biodex Balance System) and rectus abdominis, externus oblique, transverse abdominis, multifidus and erector spine muscles activity (measured by surface electromyography) while sitting and standing with usual and aligned body postures both before and after six weeks of training (three 15 minutes sessions per week) were compared in between. Balance control improved after the training program. Besides, more symmetrical activation of both sides rectus and transversus abdominis muscles, as well as increased transversus abdominis muscle activation of 19% (p< 0.05), were observed. Six weeks short sessions training on unstable training machine improved balance control and increased trunk muscles activity especially in aligned body posture when standing or sitting on unstable surface.

  7. A Health Probe in College Students Living in Los Angeles and in Taiwan: Dietary Pattern, Physical Activity and Energy Balance

    Science.gov (United States)

    Wang, Li Hui; Yang, Hsin Ling; Chen, Yin Chang; Davis, Rebecca; Schwartz, Miriam E.; Tam, Chick F.

    2008-01-01

    The objective was to examine differences of dietary pattern, physical activity and energy balance in 240 college students with 137 of them enrolled in California State University, Los Angeles (LA) and the other 93 enrolled in China Medical University in Taichung, Taiwan (TW). A three-day dietary record and a 24-hour physical activity journal were…

  8. Shugoshin-1 balances Aurora B kinase activity via PP2A to promote chromosome bi-orientation

    NARCIS (Netherlands)

    Meppelink, Amanda; Kabeche, Lilian; Vromans, Martijn J M; Compton, Duane A; Lens, Susanne M A

    2015-01-01

    Correction of faulty kinetochore-microtubule attachments is essential for faithful chromosome segregation and dictated by the opposing activities of Aurora B kinase and PP1 and PP2A phosphatases. How kinase and phosphatase activities are appropriately balanced is less clear. Here, we show that a

  9. [Strength, flexibility, balance, resistance and flexibility assessment according to body mass index in active older women].

    Science.gov (United States)

    Vaquero-Cristóbal, Raquel; Martínez González-Moro, Ignacio; Alacid Cárceles, Fernando; Ros Simón, Esperanza

    2013-01-01

    Overweight and obesity are increasing at an alarming rate among older people. This is mainly because this population is predominantly sedentary. The aim of this study was to classify, according to the body mass index (BMI), a group of older active women and to evaluate the different basic physical abilities as a function of this. The BMI and fitness were evaluated in 60 elderly active women (mean age: 66.14 ± 6.59 years) using the 2-minute step test, arm curl test, chair stand test, back scratch test, chair-sit and reach-test, flamenco test, and 8-foot up-and-go test. It was found that 52.23% of the women studied had a normal BMI and 47.76% were slightly overweight. There were no cases of obesity or underweight. Women with normal BMI had better values in all tests than overweight women. Significant differences were found in the flamenco test (P<.05), and 8-foot up-and-go test (P<.01). Older women who usually do physical activity had a normal or slightly overweight BMI. It was also found that women with lower BMI have better resistance, flexibility, balance and strength. Copyright © 2012 SEGG. Published by Elsevier Espana. All rights reserved.

  10. The Activity of Menkes Disease Protein ATP7A Is Essential for Redox Balance in Mitochondria

    Energy Technology Data Exchange (ETDEWEB)

    Bhattacharjee, Ashima; Yang, Haojun; Duffy, Megan; Robinson, Emily; Conrad-Antoville, Arianrhod; Lu, Ya-Wen; Capps, Tony; Braiterman, Lelita; Wolfgang, Michael; Murphy, Michael P.; Yi, Ling; Kaler, Stephen G.; Lutsenko, Svetlana; Ralle, Martina

    2016-05-16

    Copper-transporting ATPase ATP7A is essential for mammalian copper homeostasis. Loss of ATP7A activity is associated with fatal Menkes disease and various other pathologies. In cells, ATP7A inactivation disrupts copper transport from the cytosol into the secretory pathway. Using fibroblasts from Menkes disease patients and mouse 3T3-L1 cells with a CRISPR/Cas9-inactivated ATP7A, we demonstrate that ATP7A dysfunction is also damaging to mitochondrial redox balance. In these cells, copper accumulates in nuclei, cytosol, and mitochondria, causing distinct changes in their redox environment. Quantitative imaging of live cells using GRX1-roGFP2 and HyPer sensors reveals highest glutathione oxidation and elevation of H2O2 in mitochondria, whereas the redox environment of nuclei and the cytosol is much less affected. Decreasing the H2O2 levels in mitochondria with MitoQ does not prevent glutathione oxidation; i.e. elevated copper and not H2O2 is a primary cause of glutathione oxidation. Redox misbalance does not significantly affect mitochondrion morphology or the activity of respiratory complex IV but markedly increases cell sensitivity to even mild glutathione depletion, resulting in loss of cell viability. Thus, ATP7A activity protects mitochondria from excessive copper entry, which is deleterious to redox buffers. Mitochondrial redox misbalance could significantly contribute to pathologies associated with ATP7A inactivation in tissues with paradoxical accumulation of copper (i.e. renal epithelia).

  11. Selenide isotope generator for the Galileo mission. GDS disassembly report

    International Nuclear Information System (INIS)

    1978-11-01

    The GDS-1 was disassembled to determine the cause for the rapid degradation of the output power. Unfortunately, it was not possible to relate the observations to direct causes for the degradation. However, some positive statements can be made which have an impact on the flight program. First, the outgassing and gas management techniques were shown to be adequate to maintain clean conditions within the generator. Second, the non-modular components within the generator including the receptacles on the housing were not affected by the thermal environment during operation of GDS-1. Third, a significant amount of sublimation of the P-legs has occurred during the relatively short life of 2000 + hours as shown by the bullet nosing of the legs and deposits on the cold end hardware. The fact that the generator atmosphere was not 100% xenon may have some bearing on this observation but the statement is still accurate. Fourth, all exposed N-legs display cracks and/or chips. Fifth, a great deal of misalignment of both N and P-legs was seen both visually and with radiographs. Although no definite conclusions can be made concerning the cause for the rapid degradation of performance, several of the observed conditions within the module could possibly contribute to that fact. They are: cracks in N-legs (increased resistance); deposits on edges of BeO discs (shorting of thermoelectric circuit); and bullet nosing of P-legs (increased resistance). It remains to be shown if any of these effects or the follower hangup described earlier contributed to the poor performance of GDS-1 or if another effect as yet unknown was the important factor

  12. Site-specific fatty chain-modified exenatide analogs with balanced glucoregulatory activity and prolonged in vivo activity.

    Science.gov (United States)

    Sun, Lidan; Huang, Xun; Han, Jing; Cai, Xingguang; Dai, Yuxuan; Chu, Yingying; Wang, Chuandong; Huang, Wenlong; Qian, Hai

    2016-06-15

    The therapeutic utility of exenatide (Ex-4) is limited due to short plasma half-life of 2.4h and thus numerous approaches have been used to obtain a longer action time. However, such strategies often attend to one thing and lose another. The study aimed to identify a candidate with balanced glucoregulatory activity and prolonged in vivo activity. A series of fatty chain conjugates of Ex-4 were designed and synthesized. First, thirteen cysteine modified peptides (1-13) were prepared. Peptides 1, 10, and 13 showed improved glucagon-like peptide-1 (GLP-1) receptor activate potency and were thus selected for second step modifications to yield conjugates I-1-I-9. All conjugates retained significant GLP-1 receptor activate potency and more importantly exerted enhanced albumin-binding properties and in vitro plasma stability. The protracted antidiabetic effects of the most stable I-3 were further confirmed by both multiple intraperitoneal glucose tolerance test and hypoglycemic efficacies test in vivo. Furthermore, once daily injection of I-3 to streptozotocin (STZ) induced diabetic mice achieved long-term beneficial effects on hemoglobin A1C (HbA1C) lowering and glucose tolerance. Once daily injection of I-3 to diet induced obesity (DIO) mice also achieved favorable effects on food intake, body weight, and blood chemistry. Our results suggested that I-3 was a promising agent deserving further investigation to treat obesity patients with diabetes. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Effects of physical and sporting activities on balance control in elderly people

    Science.gov (United States)

    Perrin, P. P.; Gauchard, G. C.; Perrot, C.; Jeandel, C.

    1999-01-01

    OBJECTIVE: Balance disorders increase with aging and raise the risk of accidental falls in the elderly. It has been suggested that the practice of physical and sporting activities (PSA) efficiently counteracts these age related disorders, reducing the risk of falling significantly. METHODS: This study, principally based on a period during which the subjects were engaged in PSA, included 65 healthy subjects, aged over 60, who were living at home. Three series of posturographic tests (static, dynamic with a single and fast upward tilt, and dynamic with slow sinusoidal oscillations) analysing the centre of foot pressure displacements or electromyographic responses were conducted to determine the effects of PSA practice on balance control. RESULTS: The major variables of postural control were best in subjects who had always practised PSA (AA group). Those who did not take part in PSA at all (II group) had the worst postural performances, whatever the test. Subjects having lately begun PSA practice (IA group) had good postural performances, close to those of the AA group, whereas the subjects who had stopped the practice of PSA at an early age (AI group) did not perform as well. Overall, the postural control in the group studied decreased in the order AA > IA > AI > II. CONCLUSIONS: The period during which PSA are practised seems to be of major importance, having a positive bearing on postural control. It seems that recent periods of practice have greater beneficial effects on the subject's postural stability than PSA practice only at an early age. These data are compatible with the fact that PSA are extremely useful for elderly people even if it has not been a lifelong habit. 


 PMID:10205695

  14. Can segmental model reductions quantify whole-body balance accurately during dynamic activities?

    Science.gov (United States)

    Jamkrajang, Parunchaya; Robinson, Mark A; Limroongreungrat, Weerawat; Vanrenterghem, Jos

    2017-07-01

    When investigating whole-body balance in dynamic tasks, adequately tracking the whole-body centre of mass (CoM) or derivatives such as the extrapolated centre of mass (XCoM) can be crucial but add considerable measurement efforts. The aim of this study was to investigate whether reduced kinematic models can still provide adequate CoM and XCoM representations during dynamic sporting tasks. Seventeen healthy recreationally active subjects (14 males and 3 females; age, 24.9±3.2years; height, 177.3±6.9cm; body mass 72.6±7.0kg) participated in this study. Participants completed three dynamic movements, jumping, kicking, and overarm throwing. Marker-based kinematic data were collected with 10 optoelectronic cameras at 250Hz (Oqus Qualisys, Gothenburg, Sweden). The differences between (X)CoM from a full-body model (gold standard) and (X)CoM representations based on six selected model reductions were evaluated using a Bland-Altman approach. A threshold difference was set at ±2cm to help the reader interpret which model can still provide an acceptable (X)CoM representation. Antero-posterior and medio-lateral displacement profiles of the CoM representation based on lower limbs, trunk and upper limbs showed strong agreement, slightly reduced for lower limbs and trunk only. Representations based on lower limbs only showed less strong agreement, particularly for XCoM in kicking. Overall, our results provide justification of the use of certain model reductions for specific needs, saving measurement effort whilst limiting the error of tracking (X)CoM trajectories in the context of whole-body balance investigation. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. Overoxidation of chloroplast 2-Cys peroxiredoxins: balancing toxic and signaling activities of hydrogen peroxide

    Directory of Open Access Journals (Sweden)

    Leonor ePuerto-Galán

    2013-08-01

    Full Text Available Photosynthesis, the primary source of biomass and oxygen into the biosphere, involves the transport of electrons in the presence of oxygen and, therefore, chloroplasts constitute an important source of reactive oxygen species (ROS, including hydrogen peroxide. If accumulated at high level, hydrogen peroxide may exert a toxic effect; however, it is as well an important second messenger. In order to balance the toxic and signaling activities of hydrogen peroxide its level has to be tightly controlled. To this end, chloroplasts are equipped with different antioxidant systems such as 2-Cys peroxiredoxins (2-Cys Prxs, thiol-based peroxidases able to reduce hydrogen- and organic peroxides. At high peroxide concentrations the peroxidase function of 2-Cys Prxs may become inactivated through a process of overoxidation. This inactivation has been proposed to explain the signaling function of hydrogen peroxide in eukaryotes, whereas in prokaryotes, the 2-Cys Prxs of which were considered to be insensitive to overoxidation, the signaling activity of hydrogen peroxide is less relevant. Here we discuss the current knowledge about the mechanisms controlling 2-Cys Prx overoxidation in chloroplasts, organelles with an important signaling function in plants. Given the prokaryotic origin of chloroplasts, we discuss the occurrence of 2-Cys Prx overoxidation in cyanobacteria with the aim of identifying similarities between chloroplasts and their ancestors regarding their response to hydrogen peroxide.

  16. Role of Melatonin in Cell-Wall Disassembly and Chilling Tolerance in Cold-Stored Peach Fruit.

    Science.gov (United States)

    Cao, Shifeng; Bian, Kun; Shi, Liyu; Chung, Hsiao-Hang; Chen, Wei; Yang, Zhenfeng

    2018-06-06

    Melatonin reportedly increases chilling tolerance in postharvest peach fruit during cold storage, but information on its effects on cell-wall disassembly in chilling-injured peaches is limited. In this study, we investigated the role of cell-wall depolymerization in chilling-tolerance induction in melatonin-treated peaches. Treatment with 100 μM melatonin alleviated chilling symptoms (mealiness) characterized by a decrease in fruit firmness and increase in juice extractability in treated peaches during storage. The loss of neutral sugars, such as arabinose and galactose, in both the 1,2-cyclohexylenedinitrilotetraacetic acid (CDTA)- and Na 2 CO 3 -soluble fractions was observed at 7 days in treated peaches, but the contents increased after 28 days of storage. Atomic-force-microscopy (AFM) analysis revealed that the polysaccharide widths in the CDTA- and Na 2 CO 3 -soluble fractions in the treated fruit were mainly distributed in a shorter range, as compared with those in the control fruit. In addition, the expression profiles of a series of cell-wall-related genes showed that melatonin treatment maintained the balance between transcripts of PpPME and PpPG, which accompany the up-regulation of several other genes involved in cell-wall disassembly. Taken together, our results suggested that the reduced mealiness by melatonin was probably associated with its positive regulation of numerous cell-wall-modifying enzymes and proteins; thus, the depolymerization of the cell-wall polysaccharides in the peaches treated with melatonin was maintained, and the treated fruit could soften gradually during cold storage.

  17. A Label Correcting Algorithm for Partial Disassembly Sequences in the Production Planning for End-of-Life Products

    Directory of Open Access Journals (Sweden)

    Pei-Fang (Jennifer Tsai

    2012-01-01

    Full Text Available Remanufacturing of used products has become a strategic issue for cost-sensitive businesses. Due to the nature of uncertain supply of end-of-life (EoL products, the reverse logistic can only be sustainable with a dynamic production planning for disassembly process. This research investigates the sequencing of disassembly operations as a single-period partial disassembly optimization (SPPDO problem to minimize total disassembly cost. AND/OR graph representation is used to include all disassembly sequences of a returned product. A label correcting algorithm is proposed to find an optimal partial disassembly plan if a specific reusable subpart is retrieved from the original return. Then, a heuristic procedure that utilizes this polynomial-time algorithm is presented to solve the SPPDO problem. Numerical examples are used to demonstrate the effectiveness of this solution procedure.

  18. The Relationship between Physical Activity and Thermal Protective Clothing on Functional Balance in Firefighters

    Science.gov (United States)

    Kong, Pui W.; Suyama, Joe; Cham, Rakie; Hostler, David

    2012-01-01

    We investigated the relationship between baseline physical training and the use of firefighting thermal protective clothing (TPC) with breathing apparatus on functional balance. Twenty-three male firefighters performed a functional balance test under four gear/clothing conditions. Participants were divided into groups by physical training status,…

  19. On the sources of vegetation activity variation, and their relation with water balance in Mexico

    Science.gov (United States)

    F. Mora; L.R. Iverson

    1998-01-01

    Natural landscape surface processes are largely controlled by the relationship between climate and vegetation. Water balance integrates the effects of climate on patterns of vegetation distribution and productivity, and for that season, functional relationships can be established using water balance variables as predictors of vegetation response. In this study, we...

  20. The short version of the Activities-specific Balance Confidence (ABC) scale: Its validity, reliability, and relationship to balance impairment and falls in older adults

    OpenAIRE

    Schepens, Stacey; Goldberg, Allon; Wallace, Melissa

    2009-01-01

    A shortened version of the ABC 16-item scale (ABC-16), the ABC-6, has been proposed as an alternative balance confidence measure. We investigated whether the ABC-6 is a valid and reliable measure of balance confidence and examined its relationship to balance impairment and falls in older adults. Thirty-five community-dwelling older adults completed the ABC-16, including the six questions of the ABC-6. They also completed the following clinical balance tests: unipedal stance time (UST), functi...

  1. Centralized disassembly and packaging of spent fuel in the DOE spent fuel management system

    International Nuclear Information System (INIS)

    Johnson, E.R.

    1986-01-01

    In October 1984, E.R. Johnson Associates, Inc. (JAI) initiated a study of the prospective use of a centralized facility for the disassembly and packaging of spent fuel to support the various elements of the US Dept. of Energy (DOE) spent fuel management system, including facilities for monitored retrievable storage (MRS) and repositories. It was DOE's original plan to receive spent fuel at each repository where it would be disassembled and packaged (overpacked) for disposal purposes. Subsequently, DOE considered the prospective use of MRS of spent fuel as an option for providing safe and reliable management of spent fuel. This study was designed to consider possible advantages of the use of centralized facilities for disassembly and packaging of spent fuel at whose location storage facilities could be added as required. The study was divided into three principal technical tasks that covered: (a) development of requirements and criteria for the central disassembly and packaging facility and associated systems. (2) Development of conceptual designs for the central disassembly and packaging facility and associated systems. (3) Estimation of capital and operating costs involved for all system facilities and determination of life cycle costs for various scenarios of operation - for comparison with the reference system

  2. Mathematical and Simulation Modelling of Moisture Diffusion Mechanism during Plastic IC Packages Disassembly

    Directory of Open Access Journals (Sweden)

    Peng Mou

    2013-01-01

    Full Text Available Reuse of plastic IC packages disassembled from printed circuit boards (PCBs has significant environmental benefits and economic value. The interface delamination caused by moisture diffusion is the main failure mode of IC packages during the disassembling process, which greatly reduces the reusability and reliability of disassembled IC packages. Exploring moisture diffusion mechanism is a prerequisite to optimize prebaking processes before disassembling that is an effective way to avoid the interface delamination. To this end, a computational model with variable boundary conditions is developed based on the different combination state of water in IC packages. The distribution characteristics and mechanism of moisture diffusion behavior are analyzed including the humidity distribution field and the relation among baking temperature, water loss rate, and baking time during baking process, and then the results are validated by FEA simulation based on the improved definition of relative moisture concentration. Baking under variable temperature is proposed and compared with the baking process and baking efficiency under constant temperature to find out the optimized baking parameters. Finally, a set of curves which indicate the relation between baking energy consumption and temperature are determined under actual industrial baking experiments, which could be used as references to develop industrial standards for PCB disassembling process.

  3. An Intelligent Agent-Controlled and Robot-Based Disassembly Assistant

    Science.gov (United States)

    Jungbluth, Jan; Gerke, Wolfgang; Plapper, Peter

    2017-09-01

    One key for successful and fluent human-robot-collaboration in disassembly processes is equipping the robot system with higher autonomy and intelligence. In this paper, we present an informed software agent that controls the robot behavior to form an intelligent robot assistant for disassembly purposes. While the disassembly process first depends on the product structure, we inform the agent using a generic approach through product models. The product model is then transformed to a directed graph and used to build, share and define a coarse disassembly plan. To refine the workflow, we formulate “the problem of loosening a connection and the distribution of the work” as a search problem. The created detailed plan consists of a sequence of actions that are used to call, parametrize and execute robot programs for the fulfillment of the assistance. The aim of this research is to equip robot systems with knowledge and skills to allow them to be autonomous in the performance of their assistance to finally improve the ergonomics of disassembly workstations.

  4. ARC: A compact, high-field, disassemblable fusion nuclear science facility and demonstration power plant

    Science.gov (United States)

    Sorbom, Brandon; Ball, Justin; Palmer, Timothy; Mangiarotti, Franco; Sierchio, Jennifer; Bonoli, Paul; Kasten, Cale; Sutherland, Derek; Barnard, Harold; Haakonsen, Christian; Goh, Jon; Sung, Choongki; Whyte, Dennis

    2014-10-01

    The Affordable, Robust, Compact (ARC) reactor conceptual design aims to reduce the size, cost, and complexity of a combined Fusion Nuclear Science Facility (FNSF) and demonstration fusion pilot power plant. ARC is a 270 MWe tokamak reactor with a major radius of 3.3 m, a minor radius of 1.1 m, and an on-axis magnetic field of 9.2 T. ARC has Rare Earth Barium Copper Oxide (REBCO) superconducting toroidal field coils with joints to allow disassembly, allowing for removal and replacement of the vacuum vessel as a single component. Inboard-launched current drive of 25 MW LHRF power and 13.6 MW ICRF power is used to provide a robust, steady state core plasma far from disruptive limits. ARC uses an all-liquid blanket, consisting of low pressure, slowly flowing Fluorine Lithium Beryllium (FLiBe) molten salt. The liquid blanket acts as a working fluid, coolant, and tritium breeder, and minimizes the solid material that can become activated. The large temperature range over which FLiBe is liquid permits blanket operation at 800-900 K with single phase fluid cooling and allows use of a high-efficiency Brayton cycle for electricity production in the secondary coolant loop.

  5. Substantiation of the admissable concentration of radionuclides in the utilization of concrete from disassembled reactors

    International Nuclear Information System (INIS)

    Engovatov, I.A.; Mashkovich, V.P.; Morev, M.N.

    1995-01-01

    The complete or partial disassembly of the buildings and systems of a modern nuclear power plant results in the formation of hundreds of thousands of tons of wastes. More than 90% of this mass consists of reinforced concrete. Only a small fraction of these materials is contaminated and/or activated up to high level and must be treated as radioactive wastes that must be buried. For this reason, it is helpful to consider a variant of recycling of some of the wastes and secondary utilization of these wastes in different industrial production processes. In this paper, we analyze the concrete that is freed when a nuclear power plant is decommissioned, and in particular, we examine three scenarios: (1) stockpiling and long-term storage of concrete at an industrial site, (2) highway construction, and (3) industrial building construction. Admissable radionuclide concentrations of several isotopes are tabulated for each scenario, and the results provide the basic information for the development of standards for the utilization of the concrete wastes produced during the decommissioning of nuclear power plants

  6. Analysis of the stress-deformed condition of the disassembly parabolic antenna

    Science.gov (United States)

    Odinets, M. N.; Kaygorodtseva, N. V.; Krysova, I. V.

    2018-01-01

    Active development of satellite communications and computer-aided design systems raises the problem of designing parabolic antennas on a new round of development. The aim of the work was to investigate the influence of the design of the mirror of a parabolic antenna on its endurance under wind load. The research task was an automated analysis of the stress-deformed condition of various designs of computer models of a paraboloid mirror (segmented or holistic) at modeling the exploitation conditions. The peculiarity of the research was that the assembly model of the antenna’s mirror was subjected to rigid connections on the contacting surfaces of the segments and only then the finite element grid was generated. The analysis showed the advantage of the design of the demountable antenna, which consists of cyclic segments, in front of the construction of the holistic antenna. Calculation of the stress-deformed condition of the antennas allows us to conclude that dividing the design of the antenna’s mirror on parabolic and cyclic segments increases it strength and rigidity. In the future, this can be used to minimize the mass of antenna and the dimensions of the disassembled antenna. The presented way of modeling a mirror of a parabolic antenna using to the method of the finite-element analysis can be used in the production of antennas.

  7. Direct energy balance based active disturbance rejection control for coal-fired power plant.

    Science.gov (United States)

    Sun, Li; Hua, Qingsong; Li, Donghai; Pan, Lei; Xue, Yali; Lee, Kwang Y

    2017-09-01

    The conventional direct energy balance (DEB) based PI control can fulfill the fundamental tracking requirements of the coal-fired power plant. However, it is challenging to deal with the cases when the coal quality variation is present. To this end, this paper introduces the active disturbance rejection control (ADRC) to the DEB structure, where the coal quality variation is deemed as a kind of unknown disturbance that can be estimated and mitigated promptly. Firstly, the nonlinearity of a recent power plant model is analyzed based on the gap metric, which provides guidance on how to set the pressure set-point in line with the power demand. Secondly, the approximate decoupling effect of the DEB structure is analyzed based on the relative gain analysis in frequency domain. Finally, the synthesis of the DEB based ADRC control system is carried out based on multi-objective optimization. The optimized ADRC results show that the integrated absolute error (IAE) indices of the tracking performances in both loops can be simultaneously improved, in comparison with the DEB based PI control and H ∞ control system. The regulation performance in the presence of the coal quality variation is significantly improved under the ADRC control scheme. Moreover, the robustness of the proposed strategy is shown comparable with the H ∞ control. Copyright © 2017. Published by Elsevier Ltd.

  8. Physical Activity and Sedentary Time among Young Children in Full-Day Kindergarten: Comparing Traditional and Balanced Day Schedules

    Science.gov (United States)

    Vanderloo, Leigh M.; Tucker, Patricia

    2017-01-01

    Objective: To compare physical activity and sedentary time among young children whose schools adhere to traditional (i.e. three outdoor playtimes = 70 minutes) versus balanced day (i.e. two outdoor playtimes = ~55 minutes) schedules in Ontario full-day kindergarten classrooms. Design: The project was part of a larger, 2-year cross-sectional study.…

  9. Flux balance modeling to predict bacterial survival during pulsed-activity events

    Science.gov (United States)

    Jose, Nicholas A.; Lau, Rebecca; Swenson, Tami L.; Klitgord, Niels; Garcia-Pichel, Ferran; Bowen, Benjamin P.; Baran, Richard; Northen, Trent R.

    2018-04-01

    Desert biological soil crusts (BSCs) are cyanobacteria-dominated surface soil microbial communities common to plant interspaces in arid environments. The capability to significantly dampen their metabolism allows them to exist for extended periods in a desiccated dormant state that is highly robust to environmental stresses. However, within minutes of wetting, metabolic functions reboot, maximizing activity during infrequent permissive periods. Microcoleus vaginatus, a primary producer within the crust ecosystem and an early colonizer, initiates crust formation by binding particles in the upper layer of soil via exopolysaccharides, making microbial dominated biological soil crusts highly dependent on the viability of this organism. Previous studies have suggested that biopolymers play a central role in the survival of this organism by powering resuscitation, rapidly forming compatible solutes, and fueling metabolic activity in dark, hydrated conditions. To elucidate the mechanism of this phenomenon and provide a basis for future modeling of BSCs, we developed a manually curated, genome-scale metabolic model of Microcoleus vaginatus (iNJ1153). To validate this model, gas chromatography-mass spectroscopy (GC-MS) and liquid chromatography-mass spectroscopy (LC-MS) were used to characterize the rate of biopolymer accumulation and depletion in in hydrated Microcoleus vaginatus under light and dark conditions. Constraint-based flux balance analysis showed agreement between model predictions and experimental reaction fluxes. A significant amount of consumed carbon and light energy is invested into storage molecules glycogen and polyphosphate, while β-polyhydroxybutyrate may function as a secondary resource. Pseudo-steady-state modeling suggests that glycogen, the primary carbon source with the fastest depletion rate, will be exhausted if M. vaginatus experiences dark wetting events 4 times longer than light wetting events.

  10. Skin Redox Balance Maintenance: The Need for an Nrf2-Activator Delivery System

    Directory of Open Access Journals (Sweden)

    Maya Ben-Yehuda Greenwald

    2016-01-01

    Full Text Available The skin, being the largest organ of the body, functions as a barrier between our body and the environment. It is consistently exposed to various exogenous and endogenous stressors (e.g., air pollutants, ionizing and non-ionizing irradiation, toxins, mitochondrial metabolism, enzyme activity, inflammatory process, etc. producing reactive oxygen species (ROS and physical damage (e.g., wounds, sunburns also resulting in reactive oxygen species production. Although skin is equipped with an array of defense mechanisms to counteract reactive oxygen species, augmented exposure and continued reactive oxygen species might result in excessive oxidative stress leading to many skin disorders including inflammatory diseases, pigmenting disorders and some types of cutaneous malignancy. The nuclear factor erythroid 2-related factor 2 (Nrf2 is an emerging regulator of cellular resistance and of defensive enzymes such as the phase II enzymes. Induction of the Keap1–Nrf2 pathway may have a beneficial effect in the treatment of a large number of skin disorders by stimulating an endogenous defense mechanism. However, prolonged and enhanced activation of this pathway is detrimental and, thus, limits the therapeutic potential of Keap1–Nrf2 modulators. Here, we review the consequences of oxidative stress to the skin, and the defense mechanisms that skin is equipped with. We describe the challenges of maintaining skin redox balance and its impact on skin status and function. Finally, we suggest a novel strategy for maintenance of skin redox homeostasis by modulating the Keap1–Nrf2 pathway using nanotechnology-based delivery systems.

  11. The use of UML activity diagrams and the i* language in the modeling of the balanced scorecard implantation process

    OpenAIRE

    Haya, Mariela; Franch, Xavier; Mayol, Enric

    2005-01-01

    Business management is a complex task that can be facilitated using different methodologies and models. One of their most relevant purposes is to align the organization strategy with the daily functioning of the organization. One of these models is the Balanced Scorecard (BSC). In this paper, we propose a modeling strategy for the BSC implantation process. We will model it using UML Activity Diagrams and Strategy Dependency models of the language i*. The Activity Diagrams allow determining th...

  12. Design and analysis of sustainable computer mouse using design for disassembly methodology

    Science.gov (United States)

    Roni Sahroni, Taufik; Fitri Sukarman, Ahmad; Agung Mahardini, Karunia

    2017-12-01

    This paper presents the design and analysis of computer mouse using Design for Disassembly methodology. Basically, the existing computer mouse model consist a number of unnecessary part that cause the assembly and disassembly time in production. The objective of this project is to design a new computer mouse based on Design for Disassembly (DFD) methodology. The main methodology of this paper was proposed from sketch generation, concept selection, and concept scoring. Based on the design screening, design concept B was selected for further analysis. New design of computer mouse is proposed using fastening system. Furthermore, three materials of ABS, Polycarbonate, and PE high density were prepared to determine the environmental impact category. Sustainable analysis was conducted using software SolidWorks. As a result, PE High Density gives the lowers amount in the environmental category with great maximum stress value.

  13. Development of the spent fuel disassembling process by utilizing the 3D graphic design technology

    International Nuclear Information System (INIS)

    Song, T. K.; Lee, J. Y.; Kim, S. H.; Yun, J. S.

    2001-01-01

    For developing the spent fuel disassembling process, the 3D graphic simulation has been established by utilizing the 3D graphic design technology which is widely used in the industry. The spent fuel disassembling process consists of a downender, a rod extraction device, a rod cutting device, a pellet extracting device and a skeleton compaction device. In this study, the 3D graphical design model of these devices is implemented by conceptual design and established the virtual workcell within kinematics to motion of each device. By implementing this graphic simulation, all the unit process involved in the spent fuel disassembling processes are analyzed and optimized. The 3D graphical model and the 3D graphic simulation can be effectively used for designing the process equipment, as well as the optimized process and maintenance process

  14. Advanced disassembling technique of irradiated driver fuel assembly for continuous irradiation of fuel pins

    International Nuclear Information System (INIS)

    Ichikawa, Shoichi; Haga, Hiroyuki; Katsuyama, Kozo; Maeda, Koji; Nishinoiri, Kenji

    2012-01-01

    It was necessary to carry out continuous irradiation tests in order to obtain the irradiation data of high burn-up fuel and high neutron dose material for FaCT (Fast Reactor Cycle Technology Development) project. There, the disassembling technique of an irradiated fuel assembly was advanced in order to realize further continuous irradiation tests. Although the conventional disassembling technique had been cutting a lower end-plug of a fuel pin needed to fix fuel pins to an irradiation vehicle, the advanced disassembling technique did not need cutting a lower end-plug. As a result, it was possible to supply many irradiated fuel pins to various continuous irradiation tests for FaCT project. (author)

  15. Developmental programming of energy balance regulation: Is physical activity more "programmable" than food intake

    Science.gov (United States)

    Extensive human and animal model data show that environmental influences during critical periods of prenatal and early postnatal development can cause persistent alterations in energy balance regulation. Although a potentially important factor in the worldwide obesity epidemic, the fundamental mecha...

  16. Effect of Gait Retraining on Balance, Activities of Daily Living, Quality of Life and Depression in Stroke Patients

    Directory of Open Access Journals (Sweden)

    Majid Farhadian

    2015-12-01

    Full Text Available Objectives: Stroke is one of the most common neurological disease and it is the main cause of physical and mental disability and staying in house. Gait difficulties have high incidence in patients with stroke. So the aim of this study was to investigate the effect of gait retraining on balance, activities of daily living, quality of life and depressionin stroke patients. Methods: This study was a clinical trial without control group. Sampling was performed by convenience sampling method and 18 patients participated. After recording demographic data, Berg Balance Scale, Barthel Index, SF36 questionnaire and Beck Depression Inventory-II used in pre-test and post-test to assess balance, activities of daily living, quality of life and depression, respectively .Data were analyzed using Pearson correlation coefficient and paired T-test. Results: The results showed statistically significant correlation in pre-test and difference between mean score of the all instruments before and after the intervention. Discussion: According to high prevalence of gait difficulties in stroke patients, it seems interventions in this area is necessary. Statistical results showed that the gait retraining intervention may have a positive effect on improving balance, activities of daily living, quality of life and depression of these patients. According to lack of information in this area, further research is needed.

  17. Effects of balance training by knee joint motions on muscle activity in adult men with functional ankle instability.

    Science.gov (United States)

    Nam, Seung-Min; Kim, Won-Bok; Yun, Chang-Kyo

    2016-05-01

    [Purpose] This study examined the effects of balance training by applying knee joint movements on muscle activity in male adults with functional ankle instability. [Subjects and Methods] 28 adults with functional ankle instability, divided randomly into an experimental group, which performed balance training by applying knee joint movements for 20 minutes and ankle joint exercises for 10 minutes, and a control group, which performed ankle joint exercise for 30 minutes. Exercises were completed three times a week for 8 weeks. Electromyographic values of the tibialis anterior, peroneus longus, peroneus brevis, and the lateral gastrocnemius muscles were obtained to compare and analyze muscle activity before and after the experiments in each group. [Results] The experimental group had significant increases in muscle activity in the tibialis anterior, peroneus longus, and lateral gastrocnemius muscles, while muscle activity in the peroneus brevis increased without significance. The control group had significant increases in muscle activity in the tibialis anterior and peroneus longus, while muscle activity in the peroneus brevis and lateral gastrocnemius muscles increased without significance. [Conclusion] In conclusion, balance training by applying knee joint movements can be recommended as a treatment method for patients with functional ankle instability.

  18. An active balance board system with real-time control of stiffness and time-delay to assess mechanisms of postural stability.

    Science.gov (United States)

    Cruise, Denise R; Chagdes, James R; Liddy, Joshua J; Rietdyk, Shirley; Haddad, Jeffrey M; Zelaznik, Howard N; Raman, Arvind

    2017-07-26

    Increased time-delay in the neuromuscular system caused by neurological disorders, concussions, or advancing age is an important factor contributing to balance loss (Chagdes et al., 2013, 2016a,b). We present the design and fabrication of an active balance board system that allows for a systematic study of stiffness and time-delay induced instabilities in standing posture. Although current commercial balance boards allow for variable stiffness, they do not allow for manipulation of time-delay. Having two controllable parameters can more accurately determine the cause of balance deficiencies, and allows us to induce instabilities even in healthy populations. An inverted pendulum model of human posture on such an active balance board predicts that reduced board rotational stiffness destabilizes upright posture through board tipping, and limit cycle oscillations about the upright position emerge as feedback time-delay is increased. We validate these two mechanisms of instability on the designed balance board, showing that rotational stiffness and board time-delay induced the predicted postural instabilities in healthy, young adults. Although current commercial balance boards utilize control of rotational stiffness, real-time control of both stiffness and time-delay on an active balance board is a novel and innovative manipulation to reveal balance deficiencies and potentially improve individualized balance training by targeting multiple dimensions contributing to standing balance. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. The short version of the Activities-specific Balance Confidence (ABC) scale: its validity, reliability, and relationship to balance impairment and falls in older adults.

    Science.gov (United States)

    Schepens, Stacey; Goldberg, Allon; Wallace, Melissa

    2010-01-01

    A shortened version of the ABC 16-item scale (ABC-16), the ABC-6, has been proposed as an alternative balance confidence measure. We investigated whether the ABC-6 is a valid and reliable measure of balance confidence and examined its relationship to balance impairment and falls in older adults. Thirty-five community-dwelling older adults completed the ABC-16, including the 6 questions of the ABC-6. They also completed the following clinical balance tests: unipedal stance time (UST), functional reach (FR), Timed Up and Go (TUG), and maximum step length (MSL). Participants reported 12-month falls history. Balance confidence on the ABC-6 was significantly lower than on the ABC-16, however scores were highly correlated. Fallers reported lower balance confidence than non-fallers as measured by the ABC-6 scale, but confidence did not differ between the groups with the ABC-16. The ABC-6 significantly correlated with all balance tests assessed and number of falls. The ABC-16 significantly correlated with all balance tests assessed, but not with number of falls. Test-retest reliability for the ABC-16 and ABC-6 was good to excellent. The ABC-6 is a valid and reliable measure of balance confidence in community-dwelling older adults, and shows stronger relationships to falls than does the ABC-16. The ABC-6 may be a more useful balance confidence assessment tool than the ABC-16. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

  20. Activities-specific balance confidence scale for predicting future falls in Indian older adults

    Directory of Open Access Journals (Sweden)

    Moiz JA

    2017-04-01

    Full Text Available Jamal Ali Moiz,1 Vishal Bansal,2 Majumi M Noohu,1 Shailendra Nath Gaur,3 Mohammad Ejaz Hussain,1 Shahnawaz Anwer,4,5 Ahmad Alghadir4 1Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia, New Delhi, India; 2Department of Physiology, 3Department of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India; 4Rehabilitation Research Chair, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia; 5Department of Musculoskeletal Science, Dr D.Y. Patil College of Physiotherapy, Dr D.Y. Patil Vidyapeeth, Pune, India Background: Activities-specific balance confidence (ABC scale is a subjective measure of confidence in performing various ambulatory activities without falling or experiencing a sense of unsteadiness. Objective: This study aimed to examine the ability of the Hindi version of the ABC scale (ABC-H scale to discriminate between fallers and non-fallers and to examine its predictive validity for prospective falls. Design: This was a prospective cohort study. Materials and methods: A total of 125 community-dwelling older adults (88 were men completed the ABC-H scale. The occurrence of falls over the follow-up period of 12 months was recorded. Discriminative validity was analyzed by comparing the total ABC-H scale scores between the faller and non-faller groups. A receiver operating characteristic curve analysis and a logistic regression analysis were used to examine the predictive accuracy of the ABC-H scale. Results: The mean ABC-H scale score of the faller group was significantly lower than that of the non-faller group (52.6±8.1 vs 73.1±12.2; P<0.001. The optimal cutoff value for distinguishing faller and non-faller adults was ≤58.13. The sensitivity, specificity, area under the curve, and positive and negative likelihood ratios of the cutoff score were 86.3%, 87.3%, 0.91 (P<0.001, 6.84, and 0.16, respectively. The percentage test accuracy and false-positive and

  1. Regulation of Liver Energy Balance by the Nuclear Receptors Farnesoid X Receptor and Peroxisome Proliferator Activated Receptor α.

    Science.gov (United States)

    Kim, Kang Ho; Moore, David D

    2017-01-01

    The liver undergoes major changes in substrate utilization and metabolic output over the daily feeding and fasting cycle. These changes occur acutely in response to hormones such as insulin and glucagon, with rapid changes in signaling pathways mediated by protein phosphorylation and other post-translational modifications. They are also reflected in chronic alterations in gene expression in response to nutrient-sensitive transcription factors. Among these, the nuclear receptors farnesoid X receptor (FXR) and peroxisome proliferator activated receptor α (PPARα) provide an intriguing, coordinated response to maintain energy balance in the liver. FXR is activated in the fed state by bile acids returning to the liver, while PPARα is activated in the fasted state in response to the free fatty acids produced by adipocyte lipolysis or possibly other signals. Key Messages: Previous studies indicate that FXR and PPARα have opposing effects on each other's primary targets in key metabolic pathways including gluconeogenesis. Our more recent work shows that these 2 nuclear receptors coordinately regulate autophagy: FXR suppresses this pathway of nutrient and energy recovery, while PPARα activates it. Another recent study indicates that FXR activates the complement and coagulation pathway, while earlier studies identify this as a negative target of PPARα. Since secretion is a very energy- and nutrient-intensive process for hepatocytes, it is possible that FXR licenses it in the nutrient-rich fed state, while PPARα represses it to spare resources in the fasted state. Energy balance is a potential connection linking FXR and PPARα regulation of autophagy and secretion, 2 seemingly unrelated aspects of hepatocyte function. FXR and PPARα act coordinately to promote energy balance and homeostasis in the liver by regulating autophagy and potentially protein secretion. It is quite likely that their impact extends to additional pathways relevant to hepatic energy balance, and

  2. Natural killer cell signal integration balances synapse symmetry and migration.

    Directory of Open Access Journals (Sweden)

    Fiona J Culley

    2009-07-01

    Full Text Available Natural killer (NK cells discern the health of other cells by recognising the balance of activating and inhibitory ligands expressed by each target cell. However, how the integration of activating and inhibitory signals relates to formation of the NK cell immune synapse remains a central question in our understanding of NK cell recognition. Here we report that ligation of LFA-1 on NK cells induced asymmetrical cell spreading and migration. In contrast, ligation of the activating receptor NKG2D induced symmetrical spreading of ruffled lamellipodia encompassing a dynamic ring of f-actin, concurrent with polarization towards a target cell and a "stop" signal. Ligation of both LFA-1 and NKG2D together resulted in symmetrical spreading but co-ligation of inhibitory receptors reverted NK cells to an asymmetrical migratory configuration leading to inhibitory synapses being smaller and more rapidly disassembled. Using micropatterned activating and inhibitory ligands, signals were found to be continuously and locally integrated during spreading. Together, these data demonstrate that NK cells spread to form large, stable, symmetrical synapses if activating signals dominate, whereas asymmetrical migratory "kinapses" are favoured if inhibitory signals dominate. This clarifies how the integration of activating and inhibitory receptor signals is translated to an appropriate NK cell response.

  3. Balanced pan-PPAR activator bezafibrate in combination with statin: comprehensive lipids control and diabetes prevention?

    Directory of Open Access Journals (Sweden)

    Tenenbaum Alexander

    2012-11-01

    Full Text Available Abstract All fibrates are peroxisome proliferators-activated receptors (PPARs-alpha agonists with ability to decrease triglyceride and increase high density lipoprotein- cholesterol (HDL-C. However, bezafibrate has a unique characteristic profile of action since it activates all three PPAR subtypes (alpha, gamma and delta at comparable doses. Therefore, bezafibrate operates as a pan-agonist for all three PPAR isoforms. Selective PPAR gamma agonists (thiazolidinediones are used to treat type 2 diabetes mellitus (T2DM. They improve insulin sensitivity by up-regulating adipogenesis, decreasing free fatty acid levels, and reversing insulin resistance. However, selective PPAR gamma agonists also cause water retention, weight gain, peripheral edema, and congestive heart failure. The expression of PPAR beta/ delta in essentially all cell types and tissues (ubiquitous presence suggests its potential fundamental role in cellular biology. PPAR beta/ delta effects correlated with enhancement of fatty acid oxidation, energy consumption and adaptive thermogenesis. Together, these data implicate PPAR beta/delta in fuel combustion and suggest that pan-PPAR agonists that include a component of PPAR beta/delta activation might offset some of the weight gain issues seen with selective PPAR gamma agonists, as was demonstrated by bezafibrate studies. Suggestively, on the whole body level all PPARs acting as one orchestra and balanced pan-PPAR activation seems as an especially attractive pharmacological goal. Conceptually, combined PPAR gamma and alpha action can target simultaneously insulin resistance and atherogenic dyslipidemia, whereas PPAR beta/delta properties may prevent the development of overweight. Bezafibrate, as all fibrates, significantly reduced plasma triglycerides and increased HDL-C level (but considerably stronger than other major fibrates. Bezafibrate significantly decreased prevalence of small, dense low density lipoproteins particles, remnants

  4. Balanced pan-PPAR activator bezafibrate in combination with statin: comprehensive lipids control and diabetes prevention?

    Science.gov (United States)

    Tenenbaum, Alexander; Fisman, Enrique Z

    2012-11-14

    All fibrates are peroxisome proliferators-activated receptors (PPARs)-alpha agonists with ability to decrease triglyceride and increase high density lipoprotein- cholesterol (HDL-C). However, bezafibrate has a unique characteristic profile of action since it activates all three PPAR subtypes (alpha, gamma and delta) at comparable doses. Therefore, bezafibrate operates as a pan-agonist for all three PPAR isoforms. Selective PPAR gamma agonists (thiazolidinediones) are used to treat type 2 diabetes mellitus (T2DM). They improve insulin sensitivity by up-regulating adipogenesis, decreasing free fatty acid levels, and reversing insulin resistance. However, selective PPAR gamma agonists also cause water retention, weight gain, peripheral edema, and congestive heart failure. The expression of PPAR beta/ delta in essentially all cell types and tissues (ubiquitous presence) suggests its potential fundamental role in cellular biology. PPAR beta/ delta effects correlated with enhancement of fatty acid oxidation, energy consumption and adaptive thermogenesis. Together, these data implicate PPAR beta/delta in fuel combustion and suggest that pan-PPAR agonists that include a component of PPAR beta/delta activation might offset some of the weight gain issues seen with selective PPAR gamma agonists, as was demonstrated by bezafibrate studies. Suggestively, on the whole body level all PPARs acting as one orchestra and balanced pan-PPAR activation seems as an especially attractive pharmacological goal. Conceptually, combined PPAR gamma and alpha action can target simultaneously insulin resistance and atherogenic dyslipidemia, whereas PPAR beta/delta properties may prevent the development of overweight. Bezafibrate, as all fibrates, significantly reduced plasma triglycerides and increased HDL-C level (but considerably stronger than other major fibrates). Bezafibrate significantly decreased prevalence of small, dense low density lipoproteins particles, remnants, induced

  5. The Methodical Approach to Assessment of Enterprise Activity on the Basis of its Models, Based on the Balanced Scorecard

    Directory of Open Access Journals (Sweden)

    Minenkova Olena V.

    2017-12-01

    Full Text Available The article proposes the methodical approach to assessment of activity of enterprise on the basis of its models, based on the balanced scorecard. The content is presented and the following components of the methodical approach are formed: tasks, input information, list of methods and models, as well as results. Implementation of this methodical approach provides improvement of management and increase of results of enterprise activity. The place of assessment models in management of enterprise activity and formation of managerial decision has been defined. Recommendations as to the operations of decision-making procedures to increase the efficiency of enterprise have been provided.

  6. [Effects of physical activity on cognitive functions, balance and risk of falls in elderly patients with Alzheimer's dementia].

    Science.gov (United States)

    Hernandez, Salma S S; Coelho, Flávia G M; Gobbi, Sebastião; Stella, Florindo

    2010-01-01

    To analyze the effects of regular, systematic and supervised activity on the cognitive functions, balance and risk of falls of elderly patients with Alzheimer's Dementia (AD). Sixteen elderly patients (mean age 78.5+/-6.8 years) were divided into two groups: intervention group (IG; n=9) and routine group (RG; n=7). The IG exercised systematically for six months, and both groups were submitted to the following tests: Mini-Mental State Examination (MMSE), Berg Balance Scale (BBS), Timed Up-and-Go (TUG) and the agility/dynamic balance (AGIBAL) item of the American Alliance for Health, Physical Education, Recreation and Dance (AAHPERD) test battery. There was a statistically significant interaction (two-way ANOVA; F1,14=32.07; p=0.01) between groups and moments for the AGIBAL. The Mann Whitney U test indicated significant differences between groups (p=0.03), only at the post-intervention moment for the TUG measured in steps and for BBS. Therefore, no significant intergroup differences were found for the TUG, BBS and MMSE at the pre-intervention moment or at post-intervention moment for the TUG measured in seconds and MMSE. The intragroup analysis by means of the Wilcoxon test showed a significant decline in the TUG, BBS and MMSE for the RG, but not for the IG. Spearman's coefficient showed a significant correlation between the results of the MMSE and AGIBAL. Physical activity may be an important non-pharmacological approach that can benefit cognitive functions and balance and reduce the risk of falls. Moreover, agility and balance are associated with cognitive functions in elderly patients with AD.

  7. Active video games and energy balance in male adolescents: a randomized crossover trial.

    Science.gov (United States)

    Gribbon, Aidan; McNeil, Jessica; Jay, Ollie; Tremblay, Mark S; Chaput, Jean-Philippe

    2015-06-01

    Active video games (AVGs) have been shown to acutely increase energy expenditure when compared with seated video games; however, the influence of AVGs on compensatory adjustments in energy intake and expenditure is largely unknown. The aim was to examine the acute effects of AVGs on energy intake and expenditure. With the use of a randomized crossover design, 26 male adolescents (mean ± SD age: 14.5 ± 1.4 y) completed three 1-h experimental conditions: resting control, seated video game play (Xbox 360; Microsoft), and AVG play (Kinect Adventures on Xbox 360) followed by an ad libitum lunch. A validated food menu was used to assess food intake immediately after the conditions and for the remainder of the day, and a dietary record was used for the subsequent 3-d period. Energy expenditure was measured by using portable indirect calorimetry throughout each experimental condition, and an accelerometer was used to assess the subsequent 3-d period. Appetite sensations were assessed by using visual analog scales at different time points during the testing day. The primary outcomes were acute (immediately after the conditions and 24-h) and short-term (3-d) energy intake and expenditure. Energy expenditure was significantly higher (~145%; P 0.49) and 3 d after the experimental conditions (~3%; P > 0.82). No significant differences were observed in absolute energy intake immediately after the conditions (~2%; P > 0.94) or in absolute energy intake 24 h (~5%; P > 0.63) and 3 d (~9%; P > 0.53) after the experimental conditions. Finally, appetite sensations were similar between conditions at all time points (P > 0.05). The increase in energy expenditure promoted by a single session of Kinect AVG play is not associated with increased food intake but is compensated for after the intervention, resulting in no measurable change in energy balance after 24 h. These results suggest that the potential of Kinect to reduce the energy gap underlying weight gain is offset within 24 h in

  8. Pilot scale, alpha disassembly and decontamination facility at the Savannah River Laboratory

    International Nuclear Information System (INIS)

    Cadieux, J.R.; Becker, G.W. Jr.; Richardson, G.W.; Coogler, A.L.

    1982-01-01

    An alpha-contained pilot facility is being built at the Savannah River Laboratory (SRL) for research into the disassembly and dcontamination of noncombustible, Transuranic (TRU) waste. The design and program objectives for the facility are presented along with the initial test results from laboratory scale decontamination experiments with Pu-238 and Cm-244

  9. Improved Nondestructive Disassembly Process using Augmented Reality and RFID Product/Part Tracking

    Directory of Open Access Journals (Sweden)

    Ile Mircheski

    2017-11-01

    Full Text Available The waste from electric and electronic equipment and discarded automobiles in the past grew rapidly and resulted with waste in billions of tones. The aim of this paper is to present an improved non-destructive disassembly process of electromechanical products using augmented reality based devices, such as glasses, tablets or mobile phones, and RFID technology for valuable product/part tracking. The proposed method includes tagging of components of interest in the product assembly by using a RFID tag. The valuable product is marked with specific ID number written in the RFID tag, in order to declare the product. The relevant data such as material and weight of components, guidelines for non-destructive disassembly for the valuable product and removing of component of interest will be obtained with the assistance of RFID tag and a centralized database. This modular system offers guidelines for the non-destructive disassembly process for obtaining valuable component of interest intended for easy repairs, remanufacture, reuse or recycling. The guidelines are in video presentation format using augmented reality for easy visualization of non-destructive disassembly process. The benefits of proposed modular system includes biggest percentage of reuse of the valuable components, easy maintaining, improved material recycling, environmental protection and greater total return form end of life products.

  10. Hybrid disassembly system for cellular telephone end-of-life treatment

    Energy Technology Data Exchange (ETDEWEB)

    Kniebel, M.; Basdere, B.; Seliger, G. [Technical Univ. Berlin, Inst. for Machine Tools and Factory Management, Dept. of Assembly Technology and Factory Management, Berlin (Germany)

    2004-07-01

    Concern over the negative environmental impacts associated with the production, use, and end-of-life (EOL) of cellular telephones is particularly high due to large production volumes and characteristically short time scales of technological and stylistic obsolescence. Landfilled or incinerated cellular telephones create the potential for release of toxic substances. The European legislation has passed the directive on Waste of Electrical and Electronic Equipment (WEEE) to regulate their collection and appropriate end-of-life treatment. Manufacturers must conduct material recycling or remanufacturing processes to recover resources. While recovery rates can hardly be met economically by material recycling, remanufacturing and reusing cellular phones is developing into a reasonable alternative. Both end-of-life options require disassembly processes for WEEE compliant treatment. Due to the high number of different cell phone variants and their typical design that fits components into tight enclosing spaces, cellular phone disassembly becomes a challenging task. These challenges and the expected high numbers of phones to be returned in the course of the WEEE urges for automated disassembly. A hybrid disassembly system has been developed to ensure the mass-treatment of obsolete cellular phones. It has been integrated into a prototypical remanufacturing factory for cellular phones that has been planned based on market data. (orig.)

  11. Conceptual design report for the mechanical disassembly of Fort St. Vrain fuel elements

    Energy Technology Data Exchange (ETDEWEB)

    Lord, D.L. [Westinghouse Idaho Nuclear Co., Inc., Idaho Falls, ID (United States); Wadsworth, D.C.; Sekot, J.P.; Skinner, K.L. [EG and G Idaho, Inc., Idaho Falls, ID (United States)

    1993-04-01

    A conceptual design study was prepared that: (1) reviewed the operations necessary to perform the mechanical disassembly of Fort St. Vrain fuel elements; (2) contained a description and survey of equipment capable of performing the necessary functions; and (3) performed a tradeoff study for determining the preferred concepts and equipment specifications. A preferred system was recommended and engineering specifications for this system were developed.

  12. Nano-functionalized filamentous fungus hyphae with fast reversible macroscopic assembly & disassembly features.

    Science.gov (United States)

    Wang, Haiying; Li, Xiaorui; Chai, Liyuan; Zhang, Liyuan

    2015-05-18

    A uniform decoration of hyphae by polyaniline nanoparticles (PANI NPs) was achieved here. This novel hybrid structure can be effectively assembled into a film by filtration and disassembled in water by shaking. This reversible process is very fast, which promises applications in nanomaterials including adsorption.

  13. Conceptual design report for the mechanical disassembly of Fort St. Vrain fuel elements

    International Nuclear Information System (INIS)

    Lord, D.L.; Wadsworth, D.C.; Sekot, J.P.; Skinner, K.L.

    1993-04-01

    A conceptual design study was prepared that: (1) reviewed the operations necessary to perform the mechanical disassembly of Fort St. Vrain fuel elements; (2) contained a description and survey of equipment capable of performing the necessary functions; and (3) performed a tradeoff study for determining the preferred concepts and equipment specifications. A preferred system was recommended and engineering specifications for this system were developed

  14. DISA- a computer code for accident analysis of fast reactor during disassembly phase

    International Nuclear Information System (INIS)

    Yadav, R.D.S.; Gupta, H.P.

    2005-01-01

    Analysis of the hypothetical transients in fast rectors that result in the disassembly of the reactor generally consists of three phases. In the phase-l, some initiating event like control rod ejection, coolant pump failure etc. is assumed to have taken place which leads the reactor to prompt critical state where fuel melting, sodium voiding etc. take place. In fast reactor normally the fuel is not in the optimum shape and further positive reactivity may be introduced into the system due to fuel melting. Fuel slumping is assumed to take place in this phase. If prompt criticality is reached as a result of the first phase, then disassembly phase is assumed to start. In this phase the neutron transient is followed till it is terminated by the disassembly of the core which takes place due to generation of high pressure gradients and which lead the core material to move from more worth region to less worth region. Doppler feed back is taken into account and reactivity feedback due to material movement is calculated by solving the hydrodynamics equations. The third phase will calculate the effect of this transient on the reactor vessel and containment. A computer code DISA for fast reactor DISAssembly phase, which is similar to the well known code VENUS has been developed. (author)

  15. The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity

    OpenAIRE

    Bowen, David G.; Zen, Monica; Holz, Lauren; Davis, Thomas; McCaughan, Geoffrey W.; Bertolino, Patrick

    2004-01-01

    Hepatic immunobiology is paradoxical: although the liver possesses unusual tolerogenic properties, it is also the site of effective immune responses against multiple pathogens and subject to immune-mediated pathology. The mechanisms underlying this dichotomy remain unclear. Following previous work demonstrating that the liver may act as a site of primary T cell activation, we demonstrate here that the balance between immunity and tolerance in this organ is established by competition for prima...

  16. 401(k) plan asset allocation, account balances, and loan activity in 2010.

    Science.gov (United States)

    VanDerhei, Jack; Holden, Sarah; Alonso, Luis; Bass, Steven

    2011-12-01

    THE BULK OF 401(K) ASSETS CONTINUED TO BE INVESTED IN STOCKS: On average, at year-end 2010, 62 percent of 401(k) participants' assets were invested in equity securities through equity funds, the equity portion of balanced funds, and company stock. Thirty-three percent were in fixed-income securities such as stable value investments and bond and money funds. SEVENTY PERCENT OF 401(K) PLANS INCLUDED TARGET-DATE FUNDS IN THEIR INVESTMENT LINEUP AT YEAR-END 2010: At year-end 2010, 11 percent of the assets in the EBRI/ICI 401(k) database were invested in target-date funds and 36 percent of 401(k) participants held target-date funds. Also known as lifecycle funds, they are designed to offer a diversified portfolio that automatically rebalances to be more focused on income over time. MORE NEW OR RECENT HIRES INVESTED THEIR 401(K) ASSETS IN BALANCED FUNDS, INCLUDING TARGET-DATE FUNDS: For example, at year-end 2010, 44 percent of the account balances of recently hired participants in their 20s were invested in balanced funds, compared with 42 percent in 2009, and about 7 percent in 1998. A significant subset of that balanced fund category is target-date funds. At year-end 2010, 35 percent of the account balances of recently hired participants in their 20s were invested in target-date funds, compared with 31 percent at year-end 2009. 401(K) PARTICIPANTS CONTINUED TO SEEK DIVERSIFICATION OF THEIR INVESTMENTS: The share of 401(k) accounts invested in company stock continued to shrink, falling by more than a percentage point (to 8 percent) in 2010, continuing a steady decline that started in 1999. Recently hired 401(k) participants contributed to this trend: They tended to be less likely to hold employer stock. PARTICIPANTS' 401(K) LOAN BALANCES DECLINED SLIGHTLY IN 2010: In 2010, 21 percent of all 401(k) participants who were eligible for loans had loans outstanding against their 401(k) accounts, unchanged from year-end 2009, and up from 18 percent at year-end 2008. Loans

  17. Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells

    Science.gov (United States)

    Kobayashi, Hideki; Butler, Jason M.; O'Donnell, Rebekah; Kobayashi, Mariko; Ding, Bi-Sen; Bonner, Bryant; Chiu, Vi K.; Nolan, Daniel J.; Shido, Koji; Benjamin, Laura; Rafii, Shahin

    2010-01-01

    Endothelial cells establish an instructive vascular niche that reconstitutes haematopoietic stem and progenitor cells (HSPCs) through release of specific paracrine growth factors, known as angiocrine factors. However, the mechanism by which endothelial cells balance the rate of proliferation and lineage-specific differentiation of HSPCs is unknown. Here, we demonstrate that Akt activation in endothelial cells, through recruitment of mTOR, but not the FoxO pathway, upregulates specific angiocrine factors that support expansion of CD34−Flt3− KLS HSPCs with long-term haematopoietic stem cell (LT-HSC) repopulation capacity. Conversely, co-activation of Akt-stimulated endothelial cells with p42/44 MAPK shifts the balance towards maintenance and differentiation of the HSPCs. Selective activation of Akt1 in the endothelial cells of adult mice increased the number of colony forming units in the spleen and CD34−Flt3− KLS HSPCs with LT-HSC activity in the bone marrow, accelerating haematopoietic recovery. Therefore, the activation state of endothelial cells modulates reconstitution of HSPCs through the upregulation of angiocrine factors, with Akt–mTOR-activated endothelial cells supporting the self-renewal of LT-HSCs and expansion of HSPCs, whereas MAPK co-activation favours maintenance and lineage-specific differentiation of HSPCs. PMID:20972423

  18. Associations between active video gaming and other energy-balance related behaviours in adolescents: a 24-hour recall diary study.

    Science.gov (United States)

    Simons, Monique; Chinapaw, Mai J M; Brug, Johannes; Seidell, Jaap; de Vet, Emely

    2015-03-05

    Active video games may contribute to reducing time spent in sedentary activities, increasing physical activity and preventing excessive weight gain in adolescents. Active video gaming can, however, only be beneficial for weight management when it replaces sedentary activities and not other physical activity, and when it is not associated with a higher energy intake. The current study therefore examines the association between active video gaming and other energy-balance-related behaviours (EBRBs). Adolescents (12-16 years) with access to an active video game and who reported to spend at least one hour per week in active video gaming were invited to participate in the study. They were asked to complete electronic 24-hour recall diaries on five randomly assigned weekdays and two randomly assigned weekend-days in a one-month period, reporting on time spent playing active and non-active video games and on other EBRBs. Findings indicated that adolescents who reported playing active video games on assessed days also reported spending more time playing non-active video games (Median = 23.6, IQR = 56.8 minutes per week) compared to adolescents who did not report playing active video games on assessed days (Median = 10.0, IQR = 51.3 minutes per week, P games on assessed days, active video game time was positively yet weakly associated with TV/DVD time and snack consumption. Active video game time was not significantly associated with other activities and sugar-sweetened beverages intake. The results suggest that it is unlikely that time spent by adolescents in playing active video games replaces time spent in other physically active behaviours or sedentary activities. Spending more time playing active video games does seem to be associated with a small, but significant increase in intake of snacks. This suggests that interventions aimed at increasing time spent on active video gaming, may have unexpected side effects, thus warranting caution.

  19. Disassembly and physical separation of electric/electronic components layered in printed circuit boards (PCB).

    Science.gov (United States)

    Lee, Jaeryeong; Kim, Youngjin; Lee, Jae-chun

    2012-11-30

    Although printed circuit boards (PCBs) contain various elements, only the major elements (i.e., those with content levels in wt% or over grade) of and precious metals (e.g., Ag, Au, and platinum groups) contained within PCBs can be recycled. To recover other elements from PCBs, the PCBs should be properly disassembled as the first step of the recycling process. The recovery of these other elements would be beneficial for efforts to conserve scarce resources, reuse electric/electronic components (EECs), and eliminate environmental problems. This paper examines the disassembly of EECs from wasted PCBs (WPCBs) and the physical separation of these EECs using a self-designed disassembling apparatus and a 3-step separation process of sieving, magnetic separation, and dense medium separation. The disassembling efficiencies were evaluated by using the ratio of grinding area (E(area)) and the weight ratio of the detached EECs (E(weight)). In the disassembly treatment, these efficiencies were improved with an increase of grinder speed and grinder height. 97.7% (E(area)) and 98% (E(weight)) could be accomplished ultimately by 3 repetitive treatments at a grinder speed of 5500 rpm and a grinder height of 1.5mm. Through a series of physical separations, most groups of the EECs (except for the diode, transistor, and IC chip groups) could be sorted at a relatively high separation efficiency of about 75% or more. To evaluate the separation efficiency with regard to the elemental composition, the distribution ratio (R(dis)) and the concentration ratio (R(conc)) were used. 15 elements could be separated with the highest R(dis) and R(conc) in the same separated division. This result implies that the recyclability of the elements is highly feasible, even though the initial content in EECs is lower than several tens of mg/kg. Copyright © 2012 Elsevier B.V. All rights reserved.

  20. Modelling disassembled fuel bundles using CATHENA MOD-3.5a under LOCA/LOECC conditions

    Energy Technology Data Exchange (ETDEWEB)

    Lei, Q M; Sanderson, D B; Dutton, R [Atomic Energy of Canada Ltd., Pinawa, MB (Canada). Whiteshell Labs.

    1996-12-31

    CATHENA MOD-3.5a is a multipurpose thermalhydraulic computer code developed primarily to analyse postulated loss-of-coolant scenarios for CANDU nuclear reactors. The code contains a generalized heat transfer package that enables it to model the behaviour of a fuel channel in great detail. Throughout the development of the CATHENA code, considerable effort has been devoted to evaluating, validating and documenting its overall capability as a design and safety assessment tool. Specific attention has focused on its ability to predict fuel channel behaviour under postulated accident conditions. This paper describes an investigation of CATHENA`s ability to predict the thermal-chemical responses of a fuel channel in which the 37-element bundles were assumed to disassemble and rearrange into a closed-packed stack of elements at the bottom of the pressure tube. A representative disassembled bundle geometry was modelled during a simulated loss-of-coolant accident scenario using CATHENA MOD-3.5a/Rev 0, with superheated steam being the only coolant available. Thermal conduction in the radial and circumferential directions was calculated for individual fuel elements, the pressure tube, and the calandria tube. Radiation view factors for the intact and disassembled bundle geometries were calculated using a CATHENA utility program. Inter-element metal-to-metal contact was accounted for using the CATHENA solid-solid contact model. An offset pressure-tube configuration, representing a partially sagged pressure tube, and the effect of steam starvation on the exothermic zirconium-steam reaction, were included in the CATHENA model. The CATHENA-predicted results show a dramatic suppression of heat generation from the zirconium-steam reaction when bundle disassembly is initiated. The predicted results show a smaller temperature increase in the fuel sheaths and the pressure tube for the disassembled bundle geometry, compared to the temperature excursion for the intact bundle. (author

  1. Low cytoplasmic pH reduces ER-Golgi trafficking and induces disassembly of the Golgi apparatus

    Energy Technology Data Exchange (ETDEWEB)

    Soonthornsit, Jeerawat [Laboratory for Cell and Developmental Biology, Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita, Kyoto 603-8555 (Japan); Yamaguchi, Yoko; Tamura, Daisuke [Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192 (Japan); Ishida, Ryuichi; Nakakoji, Yoko; Osako, Shiho [Laboratory for Cell and Developmental Biology, Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita, Kyoto 603-8555 (Japan); Yamamoto, Akitsugu [Department of Animal Bioscience, Nagahama Institute of Bio-Science and Technology, 266 Tamura, Nagahama, Shiga, 526‐0829 (Japan); Nakamura, Nobuhiro, E-mail: osaru3@cc.kyoto-su.ac.jp [Laboratory for Cell and Developmental Biology, Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita, Kyoto 603-8555 (Japan); Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192 (Japan)

    2014-11-01

    The Golgi apparatus was dramatically disassembled when cells were incubated in a low pH medium. The cis-Golgi disassembled quickly, extended tubules and spread to the periphery of cells within 30 min. In contrast, medial- and trans-Golgi were fragmented in significantly larger structures of smaller numbers at a slower rate and remained largely in structures distinct from the cis-Golgi. Electron microscopy revealed the complete disassembly of the Golgi stack in low pH treated cells. The effect of low pH was reversible; the Golgi apparatus reassembled to form a normal ribbon-like structure within 1–2 h after the addition of a control medium. The anterograde ER to Golgi transport and retrograde Golgi to ER transport were both reduced under low pH. Phospholipase A{sub 2} inhibitors (ONO, BEL) effectively suppressed the Golgi disassembly, suggesting that the phospholipase A{sub 2} was involved in the Golgi disassembly. Over-expression of Rab1, 2, 30, 33 and 41 also suppressed the Golgi disassembly under low pH, suggesting that they have protective role against Golgi disassembly. Low pH treatment reduced cytoplasmic pH, but not the luminal pH of the Golgi apparatus, strongly suggesting that reduction of the cytoplasmic pH triggered the Golgi disassembly. Because a lower cytoplasmic pH is induced in physiological or pathological conditions, disassembly of the Golgi apparatus and reduction of vesicular transport through the Golgi apparatus may play important roles in cell physiology and pathology. Furthermore, our findings indicated that low pH treatment can serve as an important tool to analyze the molecular mechanisms that support the structure and function of the Golgi apparatus. - Highlights: • The Golgi apparatus reversibly disassembles by low pH treatment. • The cis-Golgi disassembles quickly generating tubular structures. • Both anterograde and retrograde transport between the ER and the Golgi apparatus are reduced. • Phospholipase A{sub 2} inhibitors (ONO

  2. Associations of leisure-time physical activity with balance and lower extremity strength: a validation of the neuromuscular part of the Physical Activity Pie.

    Science.gov (United States)

    Lindström, Paula J; Suni, Jaana H; Nygård, Clas-Håkan

    2009-07-01

    The importance of neuromuscular-type exercise (NME) has been recognized in recent recommendations for public health. However, the knowledge on associations and dose response of different types of leisure-time physical activity (LTPA) with musculoskeletal fitness and health is incomplete. This study evaluated the validity of the NME recommendation for public health introduced by the Physical Activity Pie. Engagement in LTPA and health-related fitness were assessed in 2 consecutive studies with the same adult population age 30 to 69 years (n = 575). Cross-sectional associations between different LTPA types and motor and musculoskeletal fitness were examined by logistic-regression models. Engagement in NME was associated with good static and dynamic balance and lower extremity strength. The highest odds ratios (OR) were found between brisk NME and static balance (most vs least fit OR = 2.39, moderate vs least fit OR = 1.94) and brisk NME and leg strength (more vs least fit OR = 2.10). Some associations were also found between brisk aerobic exercise and good balance. This cross-sectional study suggests that the recommendation for NME in the Physical Activity Pie is valid in terms of balance and leg strength, the 2 major fitness factors related to mobility functioning, especially among aging adults.

  3. The Chloroplast Division Protein ARC6 Acts to Inhibit Disassembly of GDP-bound FtsZ2.

    Science.gov (United States)

    Sung, Min Woo; Shaik, Rahamthulla; TerBush, Allan D; Osteryoung, Katherine W; Vitha, Stanislav; Holzenburg, Andreas

    2018-05-16

    Chloroplasts host photosynthesis and fulfill other metabolic functions that are essential to plant life. They have to divide by binary fission to maintain their numbers throughout cycles of cell division. Chloroplast division is achieved by a complex ring-shaped division machinery located on both the inner (stromal) and the outer (cytosolic) side of the chloroplast envelope. The inner division ring (termed the Z ring) is formed by the assembly of tubulin-like FtsZ1 and FtsZ2 proteins. ARC6 is a key chloroplast division protein that interacts with the Z ring. ARC6 spans the inner envelope membrane, is known to stabilize or maintain the Z ring, and anchors the Z ring to the inner membrane through interaction with FtsZ2. The underlying mechanism of Z-ring stabilization is not well understood. Here, biochemical and structural characterization of ARC6 was conducted using light scattering, sedimentation, and light and transmission electron microscopy. The recombinant protein was purified as a dimer. The results indicated that a truncated form of ARC6 (tARC6), representing the stromal portion of ARC6, affects FtsZ2 assembly without forming higher-order structures, and exerts its effect via FtsZ2 dynamics. tARC6 prevented GDP-induced FtsZ2 disassembly and caused a significant net increase in FtsZ2 assembly when GDP was present. Single particle analysis and 3D reconstruction were performed to elucidate the structural basis of ARC6 activity. Together, the data reveal that a dimeric form of tARC6 binds to FtsZ2 filaments and does not increase FtsZ polymerization rates but rather inhibits GDP-associated FtsZ2 disassembly. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.

  4. Competitive effect of KOH activation on the electrochemical performances of carbon nanotubes for EDLC: Balance between porosity and conductivity

    International Nuclear Information System (INIS)

    Xu Bin; Wu Feng; Su Yuefeng; Cao Gaoping; Chen Shi; Zhou Zhiming; Yang Yusheng

    2008-01-01

    This work is focused on the competitive effects on the performance of the electric double layer capacitors (EDLCs) between porosity increase and simultaneous conductivity decrease for KOH-activated carbon nanotubes (CNTs). A series of the CNTs have been activated with KOH to enhance their surface areas for application in EDLCs. The microstructure of the activated carbon nanotubes (ACNTs) is characterized with N 2 adsorption, transmission electron microscopy (TEM) observation and electric conductivity measurement. Their electrochemical performances are evaluated in aqueous KOH electrolyte with galvanostatic charge/discharge, cyclic voltammetry, and ac impedance spectroscopy. It is found that the KOH activation enhances the specific surface area of the CNTs and its specific capacitance but decreases its electric conductivity and the rate performance in EDLC. By controlling the activation of the CNTs to balance the porosity and conductivity, ACNTs with both high capacitance and good rate performance are obtained

  5. Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction.

    Science.gov (United States)

    Wu, Min; Dumalska, Iryna; Morozova, Elena; van den Pol, Anthony; Alreja, Meenakshi

    2009-10-06

    A link between energy balance and reproduction is critical for the survival of all species. Energy-consuming reproductive processes need to be aborted in the face of a negative energy balance, yet knowledge of the pathways mediating this link remains limited. Fasting and food restriction that inhibit fertility also upregulate the hypothalamic melanin-concentrating hormone (MCH) system that promotes feeding and decreases energy expenditure; MCH knockout mice are lean and have a higher metabolism but remain fertile. MCH also modulates sleep, drug abuse behavior, and mood, and MCH receptor antagonists are currently being developed as antiobesity and antidepressant drugs. Despite the clinical implications of MCH, the direct postsynaptic effects of MCH have never been reported in CNS neurons. Using patch-clamp recordings in brain slices from multiple lines of transgenic GFP mice, we demonstrate a strong inhibitory effect of MCH on an exclusive population of septal vGluT2-GnRH neurons that is activated by the puberty-triggering and preovulatory luteinizing hormone surge-mediating peptide, kisspeptin. MCH has no effect on kisspeptin-insensitive GnRH, vGluT2, cholinergic, or GABAergic neurons located within the same nucleus. The inhibitory effects of MCH are reproducible and nondesensitizing and are mediated via a direct postsynaptic Ba(2+)-sensitive K(+) channel mechanism involving the MCHR1 receptor. MCH immunoreactive fibers are in close proximity to vGluT2-GFP and GnRH-GFP neurons. Importantly, MCH blocks the excitatory effect of kisspeptin on vGluT2-GnRH neurons. Considering the role of MCH in regulating energy balance and of GnRH and kisspeptin in triggering puberty and maintaining fertility, MCH may provide a critical link between energy balance and reproduction directly at the level of the kisspeptin-activated vGluT2-GnRH neuron.

  6. Low cytoplasmic pH reduces ER-Golgi trafficking and induces disassembly of the Golgi apparatus.

    Science.gov (United States)

    Soonthornsit, Jeerawat; Yamaguchi, Yoko; Tamura, Daisuke; Ishida, Ryuichi; Nakakoji, Yoko; Osako, Shiho; Yamamoto, Akitsugu; Nakamura, Nobuhiro

    2014-11-01

    The Golgi apparatus was dramatically disassembled when cells were incubated in a low pH medium. The cis-Golgi disassembled quickly, extended tubules and spread to the periphery of cells within 30 min. In contrast, medial- and trans-Golgi were fragmented in significantly larger structures of smaller numbers at a slower rate and remained largely in structures distinct from the cis-Golgi. Electron microscopy revealed the complete disassembly of the Golgi stack in low pH treated cells. The effect of low pH was reversible; the Golgi apparatus reassembled to form a normal ribbon-like structure within 1-2h after the addition of a control medium. The anterograde ER to Golgi transport and retrograde Golgi to ER transport were both reduced under low pH. Phospholipase A2 inhibitors (ONO, BEL) effectively suppressed the Golgi disassembly, suggesting that the phospholipase A2 was involved in the Golgi disassembly. Over-expression of Rab1, 2, 30, 33 and 41 also suppressed the Golgi disassembly under low pH, suggesting that they have protective role against Golgi disassembly. Low pH treatment reduced cytoplasmic pH, but not the luminal pH of the Golgi apparatus, strongly suggesting that reduction of the cytoplasmic pH triggered the Golgi disassembly. Because a lower cytoplasmic pH is induced in physiological or pathological conditions, disassembly of the Golgi apparatus and reduction of vesicular transport through the Golgi apparatus may play important roles in cell physiology and pathology. Furthermore, our findings indicated that low pH treatment can serve as an important tool to analyze the molecular mechanisms that support the structure and function of the Golgi apparatus. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Activation of type-1 cannabinoid receptor shifts the balance between excitation and inhibition towards excitation in layer II/III pyramidal neurons of the rat prelimbic cortex

    NARCIS (Netherlands)

    den Boon, F.S.; Werkman, T.R.; Schaafsma-Zhao, Q.; Houthuijs, K.; Vitalis, T.; Kruse, C.G.; Wadman, W.J.; Chameau, P.

    2015-01-01

    Activation of the endocannabinoid (eCB) system by exogenous cannabinoids (drug abuse) can alter the physiology of the brain circuits involved in higher-order cognitive functions such as the medial prefrontal cortex (mPFC). A proper balance between excitation and inhibition (E/I balance) is critical

  8. Yoga Training Has Positive Effects on Postural Balance and Its Influence on Activities of Daily Living in People with Multiple Sclerosis: A Pilot Study.

    Science.gov (United States)

    de Oliveira, Gerson; Tavares, Maria da Consolação Cunha Gomes Fernandes; de Faria Oliveira, Jane Domingues; Rodrigues, Marcos Rojo; Santaella, Danilo Forghieri

    2016-01-01

    There is a little evidence about the influence of yoga as a complementary therapy for postural balance and its influence on activities of daily living in multiple sclerosis (MS) patients. To evaluate the influence of a six-month yoga program on postural balance and subjective impact of postural balance impairment on activities of daily living in people with MS. Randomized controlled pilot study. Protocol developed at the Adaptive Physical Activity Study Department, College of Physical Education, State University of Campinas, Brazil. A total of 12 (11 women) yoga naive people with MS randomly divided into two groups as follows: Control (C-waiting list, n = 6) and Yoga (Y-Yoga training, n = 6). Yoga group practiced postures, breathing exercises, meditation, and relaxation on weekly 60-min classes for a six-month period. The following evaluations were performed at study entry (baseline), and after six months (six months): Berg Balance Scale (BBS), Expanded Disability Status Scale (EDSS), and self-reported postural balance quality and influence of postural balance on activities of daily living. There was a significant improvement in BBS score from baseline to six months only in the Yoga group, especially in subjects with higher EDSS score, with increased quality of self-reported postural balance, and decreased influence of postural balance impairment on activities of daily living. In conclusion, a six-month yoga training is beneficial for people with MS, since it improves postural balance and decreases the influence of postural balance impairment on activities of daily living. A greater sample size is necessary to increase generalization, but it seems that yoga could be included as a feasible complementary therapy for people with MS. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Control of cell volume in the J774 macrophage by microtubule disassembly and cyclic AMP

    Science.gov (United States)

    Melmed, RN; Karanian, PJ; Berlin, RD

    1981-01-01

    We have explored the possibilities that cell volume is regulated by the status of microtubule assembly and cyclic AMP metabolism and may be coordinated with shape change. Treatment of J774.2 mouse macrophages with colchicine caused rapid microtubule disassembly and was associated with a striking increase (from 15-20 to more than 90 percent) in the proportion of cells with a large protuberance at one pole. This provided a simple experimental system in which shape changes occurred in virtually an entire cell population in suspension. Parallel changes in cell volume could then be quantified by isotope dilution techniques. We found that the shape change caused by colchicine was accompanied by a decrease in cell volume of approximately 20 percent. Nocodozole, but not lumicolchicine, caused identical changes in both cell shape and cell volume. The volume loss was not due to cell lysis nor to inhibition of pinocytosis. The mechanism of volume loss was also examined. Colchicine induced a small but reproducible increase in activity of the ouabain-sensitive Na(+), K(+)-dependent ATPase. However, inhibition of this enzyme/transport system by ouabain did not change cell volume nor did it block the colchicines-induced decrease in volume. One the other hand, SITS (4’acetamido, 4-isothiocyano 2,2’ disulfonic acid stilbene), an inhibitor of anion transport, inhibited the effects of colchicines, thus suggesting a role for an anion transport system in cell volume regulation. Because colchicine is known to activate adenylate cyclase in several systems and because cell shape changes are often induced by hormones that elevate cyclic AMP, we also examined the effects of cyclic AMP on cell volume. Agents that act to increase syclic AMP (cholera toxin, which activates adenylate cyclase; IBMX, and inhibitor of phosphodiesterase; and dibutyryl cyclic AMP) all caused a volume decrease comparable to that of colchicine. To define the effective metabolic pathway, we studied two mutants of J

  10. Pilot study comparing changes in postural control after training using a video game balance board program and 2 standard activity-based balance intervention programs.

    Science.gov (United States)

    Pluchino, Alessandra; Lee, Sae Yong; Asfour, Shihab; Roos, Bernard A; Signorile, Joseph F

    2012-07-01

    To compare the impacts of Tai Chi, a standard balance exercise program, and a video game balance board program on postural control and perceived falls risk. Randomized controlled trial. Research laboratory. Independent seniors (N=40; 72.5±8.40) began the training, 27 completed. Tai Chi, a standard balance exercise program, and a video game balance board program. The following were used as measures: Timed Up & Go, One-Leg Stance, functional reach, Tinetti Performance Oriented Mobility Assessment, force plate center of pressure (COP) and time to boundary, dynamic posturography (DP), Falls Risk for Older People-Community Setting, and Falls Efficacy Scale. No significant differences were seen between groups for any outcome measures at baseline, nor were significant time or group × time differences for any field test or questionnaire. No group × time differences were seen for any COP measures; however, significant time differences were seen for total COP, 3 of 4 anterior/posterior displacement and both velocity, and 1 displacement and 1 velocity medial/lateral measure across time for the entire sample. For DP, significant improvements in the overall score (dynamic movement analysis score), and in 2 of the 3 linear and angular measures were seen for the sample. The video game balance board program, which can be performed at home, was as effective as Tai Chi and the standard balance exercise program in improving postural control and balance dictated by the force plate postural sway and DP measures. This finding may have implications for exercise adherence because the at-home nature of the intervention eliminates many obstacles to exercise training. Copyright © 2012 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  11. Balancing activity, stability and conductivity of nanoporous core-shell iridium/iridium oxide oxygen evolution catalysts

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yong-Tae; Lopes, Pietro Papa; Park, Shin-Ae; Lee, A-Yeong; Lim, Jinkyu; Lee, Hyunjoo; Back, Seoin; Jung, Yousung; Danilovic, Nemanja; Stamenkovic, Vojislav; Erlebacher, Jonah; Snyder, Joshua; Markovic, Nenad M.

    2017-11-13

    The selection of oxide materials for catalyzing the Oxygen Evolution Reaction in acid-based electrolyzers must be guided by the proper balance between activity, stability and conductivity – a challenging mission of great importance for delivering affordable and environmentally friendly hydrogen. Here we report that the highly conductive nanoporous architecture of an iridium oxide shell on a metallic iridium core, formed through the fast dealloying of osmium from an Ir25Os75 alloy, exhibits an exceptional balance between oxygen evolution activity and stability as quantified by the Activity-Stability FactorASF. Based on this metric, the nanoporous Ir/IrO2 morphology of dealloyed Ir25Os75 shows a factor of ~30 improvement ASFrelative to conventional Ir-based oxide materials and a ~8 times improvement over dealloyed Ir25Os75 nanoparticles due to optimized stability and conductivity, respectively. We propose that the Activity-Stability FactorASF is the key “metric” for determining the technological relevance of oxide-based anodic water electrolyzer catalysts.

  12. The Balance of Fluid and Osmotic Pressures across Active Biological Membranes with Application to the Corneal Endothelium.

    Directory of Open Access Journals (Sweden)

    Xi Cheng

    Full Text Available The movement of fluid and solutes across biological membranes facilitates the transport of nutrients for living organisms and maintains the fluid and osmotic pressures in biological systems. Understanding the pressure balances across membranes is crucial for studying fluid and electrolyte homeostasis in living systems, and is an area of active research. In this study, a set of enhanced Kedem-Katchalsky (KK equations is proposed to describe fluxes of water and solutes across biological membranes, and is applied to analyze the relationship between fluid and osmotic pressures, accounting for active transport mechanisms that propel substances against their concentration gradients and for fixed charges that alter ionic distributions in separated environments. The equilibrium analysis demonstrates that the proposed theory recovers the Donnan osmotic pressure and can predict the correct fluid pressure difference across membranes, a result which cannot be achieved by existing KK theories due to the neglect of fixed charges. The steady-state analysis on active membranes suggests a new pressure mechanism which balances the fluid pressure together with the osmotic pressure. The source of this pressure arises from active ionic fluxes and from interactions between solvent and solutes in membrane transport. We apply the proposed theory to study the transendothelial fluid pressure in the in vivo cornea, which is a crucial factor maintaining the hydration and transparency of the tissue. The results show the importance of the proposed pressure mechanism in mediating stromal fluid pressure and provide a new interpretation of the pressure modulation mechanism in the in vivo cornea.

  13. Effect of animal-assisted activity on balance and quality of life in home-dwelling persons with dementia.

    Science.gov (United States)

    Olsen, Christine; Pedersen, Ingeborg; Bergland, Astrid; Enders-Slegers, Marie-José; Ihlebæk, Camilla

    2016-01-01

    Purpose of the study was to examine if animal-assisted activity with a dog (AAA) in home-dwelling persons with dementia (PWDs) attending day-care centers would have an effect on factors related to risk of fall accidents, with balance (Berg balance scale) and quality of life (Quality of Life in Late-stage Dementia) as main outcome. The project was conducted as a prospective and cluster-randomized multicenter trial with a follow-up. 16 adapted day-care centers recruited respectively 42 (intervention group) and 38 (control group with treatment as usual) home-dwelling PWDs. The intervention consisted of 30 min sessions with AAA led by a qualified dog handler twice a week for 12 weeks in groups of 3-7 participants. The significant positive effect on balance indicates that AAA might work as a multifactorial intervention in dementia care and have useful clinical implication by affecting risk of fall. ClinicalTrial.gov; NCT02008630. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Effects of truncal motor imagery practice on trunk performance, functional balance, and daily activities in acute stroke

    Directory of Open Access Journals (Sweden)

    Priyanka Shah

    2016-01-01

    Full Text Available Background: Motor imagery is beneficial to treat upper and lower limbs motor impairments in stroke patients, but the effects of imagery in the trunk recovery have not been reported. Hence, the aim is to test the effects of truncal motor imagery practice on trunk performance, functional balance, and daily activities in acute stroke patients. Methods: This pilot randomized clinical trial was conducted in acute stroke unit. Acute stroke patients with hemodynamic stability, aged between 30 and 70 years, first time stroke, and scoring <20 on trunk impairment scale (TIS were included in the study. Patients in the experimental group practiced trunk motor imagery in addition to physical training. Control group was given conventional physical therapy. The treatment intensity was 90 min/day, 6 days a week for 3 weeks duration. Trunk control test, TIS, brunel balance assessment (BBA, and Barthel index (BI were considered as the outcome measures. Results: Among 23 patients included in the study, 12 and 11 patients, respectively, in the control and experimental groups completed the intervention. Repeated measures ANOVA, i.e., timeFNx01 group factor analysis and effect size showed statistically significant improvements (P = 0.001 in the scores of TIS (1.64, BBA (1.83, and BI (0.67. Conclusion: Motor imagery of trunk in addition to the physical practice showed benefits in improving trunk performance, functional balance, and daily living in acute stroke.

  15. Balance Problems

    Science.gov (United States)

    ... often, it could be a sign of a balance problem. Balance problems can make you feel unsteady. You may ... related injuries, such as a hip fracture. Some balance problems are due to problems in the inner ...

  16. Gender-specific alteration of energy balance and circadian locomotor activity in the Crtc1 knockout mouse model of depression

    KAUST Repository

    Rossetti, Clara

    2017-12-06

    Obesity and depression are major public health concerns, and there is increasing evidence that they share etiological mechanisms. CREB-regulated transcription coactivator 1 (CRTC1) participates in neurobiological pathways involved in both mood and energy balance regulation. Crtc1 -/- mice rapidly develop a depressive-like and obese phenotype in early adulthood, and are therefore a relevant animal model to explore possible common mechanisms underlying mood disorders and obesity. Here, the obese phenotype of male and female Crtc1 -/- mice was further characterized by investigating CRTC1\\'s role in the homeostatic and hedonic regulation of food intake, as well as its influence on daily locomotor activity. Crtc1 -/- mice showed a strong gender difference in the homeostatic regulation of energy balance. Mutant males were hyperphagic and rapidly developed obesity on normal chow diet, whereas Crtc1 -/- females exhibited mild late-onset obesity without hyperphagia. Overeating of mutant males was accompanied by alterations in the expression of several orexigenic and anorexigenic hypothalamic genes, thus confirming a key role of CRTC1 in the central regulation of food intake. No alteration in preference and conditioned response for saccharine was observed in Crtc1 -/- mice, suggesting that mutant males\\' hyperphagia was not due to an altered hedonic regulation of food intake. Intriguingly, mutant males exhibited a hyperphagic behavior only during the resting (diurnal) phase of the light cycle. This abnormal feeding behavior was associated with a higher diurnal locomotor activity indicating that the lack of CRTC1 may affect circadian rhythmicity. Collectively, these findings highlight the male-specific involvement of CRTC1 in the central control of energy balance and circadian locomotor activity.

  17. Gender-specific alteration of energy balance and circadian locomotor activity in the Crtc1 knockout mouse model of depression

    KAUST Repository

    Rossetti, Clara; Sciarra, Daniel; Petit, Jean-Marie; Eap, Chin B.; Halfon, Olivier; Magistretti, Pierre J.; Boutrel, Benjamin; Cardinaux, Jean-René

    2017-01-01

    Obesity and depression are major public health concerns, and there is increasing evidence that they share etiological mechanisms. CREB-regulated transcription coactivator 1 (CRTC1) participates in neurobiological pathways involved in both mood and energy balance regulation. Crtc1 -/- mice rapidly develop a depressive-like and obese phenotype in early adulthood, and are therefore a relevant animal model to explore possible common mechanisms underlying mood disorders and obesity. Here, the obese phenotype of male and female Crtc1 -/- mice was further characterized by investigating CRTC1's role in the homeostatic and hedonic regulation of food intake, as well as its influence on daily locomotor activity. Crtc1 -/- mice showed a strong gender difference in the homeostatic regulation of energy balance. Mutant males were hyperphagic and rapidly developed obesity on normal chow diet, whereas Crtc1 -/- females exhibited mild late-onset obesity without hyperphagia. Overeating of mutant males was accompanied by alterations in the expression of several orexigenic and anorexigenic hypothalamic genes, thus confirming a key role of CRTC1 in the central regulation of food intake. No alteration in preference and conditioned response for saccharine was observed in Crtc1 -/- mice, suggesting that mutant males' hyperphagia was not due to an altered hedonic regulation of food intake. Intriguingly, mutant males exhibited a hyperphagic behavior only during the resting (diurnal) phase of the light cycle. This abnormal feeding behavior was associated with a higher diurnal locomotor activity indicating that the lack of CRTC1 may affect circadian rhythmicity. Collectively, these findings highlight the male-specific involvement of CRTC1 in the central control of energy balance and circadian locomotor activity.

  18. Evaluation of nuclear facility decommissioning projects. Three Mile Island Unit 2 reactor defueling and disassembly. Summary status report. Volume 3

    International Nuclear Information System (INIS)

    Doerge, D.H.; Miller, R.L.; Scotti, K.S.

    1986-05-01

    This document summarizes information relating to the preparations for defueling the Three Mile Island Unit 2 (TMI-2) reactor and disassembly activities being performed concurrently with decontamination of the facility. Data have been collected from activity reports, reactor containment entry records, and other sources and entered in a computerized data sysem which permits extraction/manipulation of specific data which can be used in planning for recovery from a loss of coolant event similar to that experienced at TMI-2 on March 28, 1979. This report contains summaries of man-hours, manpower, and radiation exposures incurred during the period of April 23, 1979 to April 16, 1985, in the completion of activities related to preparation for reactor defueling. Support activities conducted outside of radiation areas are not included within the scope of this report. Computerized reports included in this document are: A chronological summary listing work performed for the period; and summary reports for each major task undertaken in connection with the specific scope of this report. Presented in chronological order for the referenced time period. Manually-assembled table summaries are included for: Labor and exposures by department; and labor and exposures by major activity

  19. Cleaning, disassembly, and requalification of the FFTF in vessel handling machine

    International Nuclear Information System (INIS)

    Coops, W.J.

    1977-10-01

    The Engineering Model In Vessel Handling Machine (IVHM) was successfully removed, cleaned, disassembled, inspected, reassembled and reinstalled into the sodium test vessel at Richland, Washington. This was the first time in the United States a full size operational sodium wetted machine has been cleaned by the water vapor nitrogen process and requalified for operation. The work utilized an atmospheric control system during removal, a tank type water vapor nitrogen cleaning system and an open ''hands on'' disassembly and assembly stand. Results of the work indicate the tools, process and equipment are adequate for the non-radioactive maintenance sequence. Additionally, the work proves that a machine of this complexity can be successfully cleaned, maintained and re-used without the need to replace a large percentage of the sodium wetted parts

  20. Assembly, operation and disassembly manual for the Battelle Large Volume Water Sampler (BLVWS)

    International Nuclear Information System (INIS)

    Thomas, V.W.; Campbell, R.M.

    1984-12-01

    Assembly, operation and disassembly of the Battelle Large Volume Water Sampler (BLVWS) are described in detail. Step by step instructions of assembly, general operation and disassembly are provided to allow an operator completely unfamiliar with the sampler to successfully apply the BLVWS to his research sampling needs. The sampler permits concentration of both particulate and dissolved radionuclides from large volumes of ocean and fresh water. The water sample passes through a filtration section for particle removal then through sorption or ion exchange beds where species of interest are removed. The sampler components which contact the water being sampled are constructed of polyvinylchloride (PVC). The sampler has been successfully applied to many sampling needs over the past fifteen years. 9 references, 8 figures

  1. Negotiation over self-control and activity: an analysis of balancing in the repertoires of Finnish healthy lifestyles.

    Science.gov (United States)

    Pajari, Pia M; Jallinoja, Piia; Absetz, Pilvikki

    2006-05-01

    This study analyses arguments for and against the notion of healthy lifestyles, and the construction of responsibility for health, in group discussions in Finland. With data from four focus groups, we identified five interpretative repertoires: a strong activity repertoire reflects the dominant cultural value of health and emphasizes self-control. Three other repertoires--illness, external barriers, and weak character--share the underlying values of the activity repertoire, but exemplify situations where the individual lacks control, seeking to justify deviations from the norm of activity. One counter-repertoire, the pleasure repertoire, questions the hegemonic value of health, and discusses other competing values. The discussion of health is an ongoing dialectical process drawing from the different repertoires. In order to avoid stigmatization and to save face in the social situation of a focus group, the subjects strive to balance their accounts of behaviours considered unhealthy by also claiming healthy behaviours. They also strike a balance between extreme rigidity and carelessness, emphasizing the ideal of moderation and harmony. The findings point to a need to consider variations in and underpinnings of a "good life" at the individual level. Encouraging people to specify the meaning and content of moderation in their personal lives could provide a new perspective for health education and health promotion.

  2. Underwater Nuclear Fuel Disassembly and Rod Storage Process and Equipment Description. Volume II

    International Nuclear Information System (INIS)

    Viebrock, J.M.

    1981-09-01

    The process, equipment, and the demonstration of the Underwater Nuclear Fuel Disassembly and Rod Storage System are presented. The process was shown to be a viable means of increasing spent fuel pool storage density by taking apart fuel assemblies and storing the fuel rods in a denser fashion than in the original storage racks. The assembly's nonfuel-bearing waste is compacted and containerized. The report documents design criteria and analysis, fabrication, demonstration program results, and proposed enhancements to the system

  3. Remote disassembly of radioactively contaminated vessels by means of an arc saw

    International Nuclear Information System (INIS)

    Beitel, G.A.

    1977-01-01

    The arc saw, a newly developed tool, is a toothless circular saw which cuts by means of an electric arc. Cutting speeds between 20 to 30 cm 2 /S and depths up to 45 cm are possible. There is no mechanical contact between blade and work piece, no binding, and no blade breakage. The arc saw will be applied to the rapid and remote disassembly of multiple ton, contaminated stainless steel vessels

  4. The Interplay of Energy Balance and Daily Timing of Activity in a Subterranean Rodent: A Laboratory and Field Approach.

    Science.gov (United States)

    Tachinardi, Patricia; Valentinuzzi, Verónica S; Oda, Gisele A; Buck, C Loren

    The tuco-tuco (Ctenomys aff. knighti) is among the rodent species known to be nocturnal under standard laboratory conditions and diurnal under natural conditions. The circadian thermoenergetics (CTE) hypothesis postulates that switches in activity timing are a response to energetic challenges; daytime activity reduces thermoregulatory costs by consolidating activity to the warmest part of the day. Studying wild animals under both captive and natural conditions can increase understanding of how temporal activity patterns are shaped by the environment and could serve as a test of the CTE hypothesis. We estimated the effects of activity timing on energy expenditure for the tuco-tuco by combining laboratory measurements of metabolic rate with environmental temperature records in both winter and summer. We showed that, in winter, there would be considerable energy savings if activity is allocated at least partially during daylight, lending support to the CTE hypothesis. In summer, the impact of activity timing on energy expenditure is small, suggesting that during this season other factors, such as predation risk, water balance, and social interaction, may have more important roles than energetics in the determination of activity time.

  5. A question of balance: Explaining differences between parental and grandparental perspectives on preschoolers' feeding and physical activity.

    Science.gov (United States)

    Eli, Karin; Howell, Kyndal; Fisher, Philip A; Nowicka, Paulina

    2016-04-01

    Although one quarter of US and UK families rely on grandparents as the main providers of informal childcare, grandparental perspectives on the feeding and physical activity of young children remain understudied. The study's aim was to elucidate parents' and grandparents' perspectives on young children's feeding and physical activity, and identify how they negotiate potential differences between these perspectives. We interviewed 22 parents and 27 grandparents from 16 families of children aged 3-5 years in the Pacific Northwest, US. Using familial homeostasis as a novel theoretical framework, the interviews were analyzed to assess differences between parental and grandparental perspectives on feeding and physical activity. The analysis yielded six thematic categories: (1) disagreements about feeding stem from parents' and grandparents' differing definitions of healthy feeding; (2) differences between parents' and grandparents' feeding practices reflect differences in perceived caretaking roles; (3) parents and grandparents negotiate differences in feeding practices through grandparental compliance and parental compromise; (4) differences in preschoolers' physical activity are influenced by parents' and grandparents' own access to and engagement in physical activity; (5) parents and grandparents express few disagreements about preschoolers' screen-time; (6) parents and grandparents rarely discuss preschoolers' physical activity. The findings suggest that parental and grandparental decision-making about feeding and exercise is informed by ideas of what constitutes familial balance and a balanced lifestyle for a preschool aged child, rather than by the child's weight status. Parents and grandparents appear to engage in practices designed to preserve familial homeostasis, which may provide a compelling explanation for the persistent difficulties in implementing family-based childhood obesity interventions. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. MgATP hydrolysis destabilizes the interaction between subunit H and yeast V1-ATPase, highlighting H's role in V-ATPase regulation by reversible disassembly.

    Science.gov (United States)

    Sharma, Stuti; Oot, Rebecca A; Wilkens, Stephan

    2018-05-12

    Vacuolar H+-ATPases (V-ATPases; V1Vo-ATPases) are rotary motor proton pumps that acidify intracellular compartments and in some tissues, the extracellular space. V-ATPase is regulated by reversible disassembly into autoinhibited V1-ATPase and Vo proton channel sectors. An important player in V-ATPase regulation is subunit H, which binds at the interface of V1 and Vo. H is required for MgATPase activity in holo V-ATPase, but also for stabilizing the MgADP inhibited state in membrane detached V1. However, how H fulfills these two functions is poorly understood. To characterize the H-V1 interaction and its role in reversible disassembly, we determined binding affinities of full length H and its N-terminal domain (HNT) for an isolated heterodimer of subunits E and G (EG), the N-terminal domain of subunit a (aNT), and V1 lacking subunit H (V1ΔH). Using isothermal titration calorimetry (ITC) and biolayer interferometry (BLI), we show that HNT binds EG with moderate affinity, that full length H binds aNT weakly, and that both H and HNT bind V1ΔH with high affinity. We also found that only one molecule of HNT binds V1ΔH with high affinity, suggesting conformational asymmetry of the three EG heterodimers in V1ΔH. Moreover, MgATP hydrolysis-driven conformational changes in V1 destabilized the interaction of H, or HNT, with V1ΔH, suggesting an interplay between MgADP inhibition and subunit H. Our observation that H binding is affected by MgATP hydrolysis in V1 points to H's role in the mechanism of reversible disassembly. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.

  7. Increased neck muscle activity and impaired balance among females with whiplash-related chronic neck pain

    DEFF Research Database (Denmark)

    Juul-Kristensen, Birgit; Clausen, Brian; Ris Hansen, Inge

    2013-01-01

    To investigate neck muscle activity and postural control in patients with whiplash-associated disorder compared with healthy controls.......To investigate neck muscle activity and postural control in patients with whiplash-associated disorder compared with healthy controls....

  8. Artificial biofilms establish the role of matrix interactions in staphylococcal biofilm assembly and disassembly

    Science.gov (United States)

    Stewart, Elizabeth J.; Ganesan, Mahesh; Younger, John G.; Solomon, Michael J.

    2015-01-01

    We demonstrate that the microstructural and mechanical properties of bacterial biofilms can be created through colloidal self-assembly of cells and polymers, and thereby link the complex material properties of biofilms to well understood colloidal and polymeric behaviors. This finding is applied to soften and disassemble staphylococcal biofilms through pH changes. Bacterial biofilms are viscoelastic, structured communities of cells encapsulated in an extracellular polymeric substance (EPS) comprised of polysaccharides, proteins, and DNA. Although the identity and abundance of EPS macromolecules are known, how these matrix materials interact with themselves and bacterial cells to generate biofilm morphology and mechanics is not understood. Here, we find that the colloidal self-assembly of Staphylococcus epidermidis RP62A cells and polysaccharides into viscoelastic biofilms is driven by thermodynamic phase instability of EPS. pH conditions that induce phase instability of chitosan produce artificial S. epidermidis biofilms whose mechanics match natural S. epidermidis biofilms. Furthermore, pH-induced solubilization of the matrix triggers disassembly in both artificial and natural S. epidermidis biofilms. This pH-induced disassembly occurs in biofilms formed by five additional staphylococcal strains, including three clinical isolates. Our findings suggest that colloidal self-assembly of cells and matrix polymers produces biofilm viscoelasticity and that biofilm control strategies can exploit this mechanism. PMID:26272750

  9. What if the hand piece spring disassembles during robotic radical prostatectomy?

    Science.gov (United States)

    Akbulut, Ziya; Canda, Abdullah Erdem; Atmaca, Ali Fuat; Asil, Erem; Isgoren, Egemen; Balbay, Mevlana Derya

    2011-01-01

    Robot-assisted laparoscopic radical prostatectomy (RALRP) is successfully being performed for treating prostate cancer (PCa). However, instrumentation failure associated with robotic procedures represents a unique new problem. We report the successful completion of RALRP in spite of a disassembled hand piece spring during the procedure. A PubMed/Medline search was made concerning robotic malfunction and robot-assisted laparoscopic radical prostatectomy to discuss our experience. We performed RALRP in a 60-year-old male patient with localized PCa. During the procedure, the spring of the hand piece disassembled, and we were not able to reassemble it. We completed the procedure successfully however without fixing the disassembled hand piece spring. We were able to grasp tissue and needles when we brought our fingers together. The only movement we needed to do was to move fingers apart to release tissue or needles caught by robotic instrument. Although malfunction risk related to the da Vinci Surgical System seems to be very low, it might still occur. Sometimes, simple maneuvers may compensate for the failed function as occurred in our case. However, patients should be informed before the operation about the possibility of converting their procedure to laparoscopic or open due to robotic malfunction.

  10. Phosphorylation of p37 is important for Golgi disassembly at mitosis

    International Nuclear Information System (INIS)

    Kaneko, Yayoi; Tamura, Kaori; Totsukawa, Go; Kondo, Hisao

    2010-01-01

    Research highlights: → p37 is phosphorylated on Serine-56 and Threonine-59 by Cdc2 at mitosis. → Phosphorylated p37 does not bind to Golgi membranes. → p37 phosphorylation inhibits p97/p37-mediated Golgi membrane fusion. -- Abstract: In mammals, the Golgi apparatus is disassembled at early mitosis and reassembled at the end of mitosis. For Golgi disassembly, membrane fusion needs to be blocked. Golgi biogenesis requires two distinct p97ATPase-mediated membrane fusion, the p97/p47 and p97/p37 pathways. We previously reported that p47 phosphorylation on Serine-140 by Cdc2 results in mitotic inhibition of the p97/p47 pathway . In this study, we demonstrate that p37 is phosphorylated on Serine-56 and Threonine-59 by Cdc2 at mitosis, and this phosphorylated p37 does not bind to Golgi membranes. Using an in vitro Golgi reassembly assay, we show that mutated p37(S56D, T59D), which mimics mitotic phosphorylation, does not cause any cisternal regrowth, indicating that p37 phosphorylation inhibits the p97/p37 pathway. Our results demonstrate that p37 phosphorylation on Serine-56 and Threonine-59 is important for Golgi disassembly at mitosis.

  11. Design-only conceptual design report for pit disassembly and conversion facility. Rev 0

    International Nuclear Information System (INIS)

    Zygmunt, S.; Christensen, L.; Richardson, C.

    1997-01-01

    This design-only conceptual design report (DOCDR) was prepared to support a funding request by the Department of Energy (DOE)-Office of Fissile Material Disposition (OFMD) for engineering design of the Pit Disassembly and Conversion Facility (PDCF) Project No. 99-D-141. The PDCF will be used to disassemble the nation's inventory of surplus nuclear weapons pits and convert the plutonium recovered from those pits into a form suitable for storage, international inspection, and final disposition. The PDCF is a complex consisting of a hardened building that will contain the plutonium processes in a safe and secure manner, and conventional buildings and structures that will house support personnel, systems, and equipment. The PDCF uses the Advanced Recovery and Integrated Extraction System (ARIES), a low waste, modular pyroprocessing system to convert pits to plutonium oxide. The PDCF project consists of engineering and design, and construction of the buildings and structures, and engineering and design, procurement, installation, testing and start-up of equipment to disassemble pits and convert plutonium in pits to oxide form. The facility is planned to operate for 10 years, averaging 3.5 metric tons (3.86 tons) of plutonium metal per year. On conclusion of operations, the PDCF will be decontaminated and decommissioned

  12. Design-only conceptual design report for pit disassembly and conversion facility. Rev 0

    Energy Technology Data Exchange (ETDEWEB)

    Zygmunt, S.; Christensen, L.; Richardson, C.

    1997-12-12

    This design-only conceptual design report (DOCDR) was prepared to support a funding request by the Department of Energy (DOE)-Office of Fissile Material Disposition (OFMD) for engineering design of the Pit Disassembly and Conversion Facility (PDCF) Project No. 99-D-141. The PDCF will be used to disassemble the nation`s inventory of surplus nuclear weapons pits and convert the plutonium recovered from those pits into a form suitable for storage, international inspection, and final disposition. The PDCF is a complex consisting of a hardened building that will contain the plutonium processes in a safe and secure manner, and conventional buildings and structures that will house support personnel, systems, and equipment. The PDCF uses the Advanced Recovery and Integrated Extraction System (ARIES), a low waste, modular pyroprocessing system to convert pits to plutonium oxide. The PDCF project consists of engineering and design, and construction of the buildings and structures, and engineering and design, procurement, installation, testing and start-up of equipment to disassemble pits and convert plutonium in pits to oxide form. The facility is planned to operate for 10 years, averaging 3.5 metric tons (3.86 tons) of plutonium metal per year. On conclusion of operations, the PDCF will be decontaminated and decommissioned.

  13. A balancing act of the brain: activations and deactivations driven by cognitive load

    OpenAIRE

    Arsalidou, Marie; Pascual-Leone, Juan; Johnson, Janice; Morris, Drew; Taylor, Margot J

    2013-01-01

    The majority of neuroimaging studies focus on brain activity during performance of cognitive tasks; however, some studies focus on brain areas that activate in the absence of a task. Despite the surge of research comparing these contrasted areas of brain function, their interrelation is not well understood. We systematically manipulated cognitive load in a working memory task to examine concurrently the relation between activity elicited by the task versus activity during control conditions. ...

  14. Exergame and Balance Training modulate Prefrontal Brain Activity during Walking and enhance Executive Function in Older Adults

    Directory of Open Access Journals (Sweden)

    Patrick eEggenberger

    2016-04-01

    Full Text Available Different types of exercise training have the potential to induce structural and functional brain plasticity in the elderly. Thereby, functional brain adaptations were observed during cognitive tasks in functional magnetic resonance imaging studies that correlated with improved cognitive performance. This study aimed to investigate if exercise training induces functional brain plasticity during challenging treadmill walking and elicits associated changes in cognitive executive functions. Forty-two elderly participants were recruited and randomly assigned to either interactive cognitive-motor video game dancing (DANCE or balance and stretching training (BALANCE. The 8-week intervention included three sessions of 30 minutes per week and was completed by 33 participants (mean age 74.9±6.9 years. Prefrontal cortex (PFC activity during preferred and fast walking speed on a treadmill was assessed applying functional near infrared spectroscopy pre- and post-intervention. Additionally, executive functions comprising shifting, inhibition, and working memory were assessed. The results showed that both interventions significantly reduced left and right hemispheric PFC oxygenation during the acceleration of walking (p < .05 or trend, r = .25 to .36, while DANCE showed a larger reduction at the end of the 30-second walking task compared to BALANCE in the left PFC (F(1, 31 = 3.54, p = .035, r = .32. These exercise training induced modulations in PFC oxygenation correlated with improved executive functions (p < .05 or trend, r = .31 to .50. The observed reductions in PFC activity may release cognitive resources to focus attention on other processes while walking, which could be relevant to improve mobility and falls prevention in the elderly. This study provides a deeper understanding of the associations between exercise training, brain function during walking, and cognition in older adults.

  15. Balance Problems

    Science.gov (United States)

    ... fully trust your sense of balance. Loss of balance also raises the risk of falls. This is a serious and even life-threatening ... 65. Balance disorders are serious because of the risk of falls. But occasionally balance problems may warn of another health condition, such ...

  16. "Right-sourcing" or obtaining the correct balance between in-house activity and the purchase of external services

    CERN Document Server

    Ninin, P

    2003-01-01

    During the last few years, and more particularly to face the LHC construction, several Information Technology activities of the ST Division have been outsourced. This concerns various domains such as desktop support, application software development, system maintenance as well as turn-key control systems. Among other motivations, this tactical approach was seen as a way to achieve higher product quality and service rationalization. The outsourcing success of IT activities resides in the mastering of a complex process that includes amongst other specification, purchasing, negotiation, contract management skills on top of advanced technical knowledge. The perception of the success of outsourcing differs also from one stakeholder to another. Nowadays, as CERN encounters a cash-flow issue, in-sourcing is investigated as an alternative path for savings. From this experience and the survey of current practice in industry, this paper analyses various parameters that should be considered to find the correct balance b...

  17. Disassembly of microtubules and inhibition of neurite outgrowth, neuroblastoma cell proliferation, and MAP kinase tyrosine dephosphorylation by dibenzyl trisulphide.

    Science.gov (United States)

    Rösner, H; Williams, L A; Jung, A; Kraus, W

    2001-08-22

    Dibenzyl trisulphide (DTS), a main lipophilic compound in Petiveria alliacea L. (Phytolaccaceae), was identified as one of the active immunomodulatory compounds in extracts of the plant. To learn more about its biological activities and molecular mechanisms, we conducted one-dimensional NMR interaction studies with bovine serum albumin (BSA) and tested DTS and related compounds in two well-established neuronal cell-and-tissue culture systems. We found that DTS preferentially binds to an aromatic region of BSA which is rich in tyrosyl residues. In SH-SY5Y neuroblastoma cells, DTS attenuates the dephosphorylation of tyrosyl residues of MAP kinase (erk1/erk2). In the same neuroblastoma cell line and in Wistar 38 human lung fibroblasts, DTS causes a reversible disassembly of microtubules, but it did not affect actin dynamics. Probably due to the disruption of the microtubule dynamics, DTS also inhibits neuroblastoma cell proliferation and neurite outgrowth from spinal cord explants. Related dibenzyl compounds with none, one, or two sulphur atoms were found to be significantly less effective. These data confirmed that the natural compound DTS has a diverse spectrum of biological properties, including cytostatic and neurotoxic actions in addition to immunomodulatory activities.

  18. Hydrogen permeation measurement of the reduced activation ferritic steel F82H by the vacuum thermo-balance method

    International Nuclear Information System (INIS)

    Yoshida, Hajime; Enoeda, Mikio; Abe, Tetsuya; Akiba, Masato

    2005-03-01

    Hydrogen permeation fluxes of the reduced activation ferritic steel F82H were quantitatively measured by a newly proposed method, vacuum thermo-balance method, for a precise estimation of tritium leakage in a fusion reactor. We prepared sample capsules made of F82H, which enclosed hydrogen gas. The hydrogen in the capsules permeated through the capsule wall, and subsequently desorbed from the capsule surface during isothermal heating. The vacuum thermo-balance method allows simultaneous measurement of the hydrogen permeation flux by two independent methods, namely, the net weight reduction of the sample capsule and exhaust gas analysis. Thus the simultaneous measurements by two independent methods increase the reliability of the permeability measurement. When the gas pressure of enclosed hydrogen was 0.8 atm at the sample temperature of 673 K, the hydrogen permeation flux of F82H obtained by the net weight reduction and the exhaust gas analysis was 0.75x10 18 (H 2 /m 2 s) and 2.2x10 18 (H 2 /m 2 s), respectively. The ratio of the hydrogen permeation fluxes obtained by the net weight reduction to that measured by the exhaust gas analysis was in the range from 1/4 to 1/1 in this experiment. The temperature dependence of the estimated permeation flux was similar in both methods. Taking the uncertainties of both measurements into consideration, both results are supposed to be consistent. The enhancement of hydrogen permeation flux was observed from the sample of which outer surface was mechanically polished. Through the present experiments, it has been demonstrated that the vacuum thermo-balance method is effective for the measurement of hydrogen permeation rate of F82H. (author)

  19. Evidence of impaired brain activity balance after passive sensorimotor stimulation in multiple sclerosis.

    Directory of Open Access Journals (Sweden)

    Nikolaos Petsas

    Full Text Available OBJECTIVES: Examination of sensorimotor activation alone in multiple sclerosis (MS patients may not yield a comprehensive view of cerebral response to task stimulation. Additional information may be obtained by examining the negative BOLD response (deactivation. Aim of this work was to characterize activation and deactivation patterns during passive hand movements in MS patients. METHODS: 13 relapsing remitting-MS patients (RRMS, 18 secondary progressive-MS patients (SPMS and 15 healthy controls (HC underwent an fMRI study during passive right-hand movements. Activation and deactivation contrasts in the three groups were entered into ANOVA, age and gender corrected. Post-hoc analysis was performed with one-sample and two-sample t-tests. For each patient we obtained lesion volume (LV from both T1- and T2-weighted images. RESULTS: Activations showed a progressive extension to the ipsilateral brain hemisphere according to the group and the clinical form (HCactivation in the contralateral sensorimotor cortex was significantly correlated with that of deactivation in the DMN in HC and RRMS, but not in SPMS. Both increased activation and decreased deactivation patterns correlated with LV. CONCLUSION: In RRMS patients, increased cortical activation was associated with increased deactivation of the posterior cortex suggesting a greater resting-state activity in the DMN, probably aimed at facilitating sensorimotor circuit engagement during task performance. In SPMS the coupling between increased sensorimotor activation/increased DMN deactivation was not observed suggesting disorganization between anticorrelated functional networks as a consequence of a higher

  20. Digitalis-like activity in human plasma: Relation to blood pressure and sodium balance

    Energy Technology Data Exchange (ETDEWEB)

    Goto, A.; Yamada, K.; Ishii, M.; Sugimoto, T. (Univ. of Tokyo (Japan))

    1990-10-01

    PURPOSE: On the assumption that renal tubular cells are more important as the target cells for a natriuretic factor than blood cells, we used a well-characterized cultured renal tubular cell line, Madin-Darby canine kidney (MDCK), cells to monitor the circulating digitalis-like factor in human plasma and examine its role in the regulation of blood pressure and sodium balance. SUBJECTS AND METHODS: We investigated the effects of plasma on binding of radioactive ouabain to monolayered MDCK cells in order to determine the level of a circulating digitalis-like factor. First, we measured specific 3H-ouabain binding to MDCK cells in the presence of plasma from 71 outpatients (34 normotensive subjects and 37 hypertensive patients) after incubation for 4 hours. Second, we measured specific 3H-ouabain binding after incubation of cells with plasma from 16 hospitalized subjects (eight normotensive subjects and eight hypertensive patients) receiving low and high sodium diets. RESULTS: In Study 1, ouabain binding was lower by 30% with plasma from hypertensive patients than with plasma from normotensive subjects (p less than 0.01). There was a significant negative correlation between individual subject's systolic or mean blood pressure and ouabain binding (r = -0.34, p less than 0.01 or r = -0.29, p less than 0.01). In Study 2, ouabain binding was also significantly reduced by 25% in the presence of plasma from hypertensive subjects as compared with plasma from normotensive subjects irrespective of sodium intake (p less than 0.01). A significant negative correlation was also found for all subjects between either systolic, diastolic, or mean blood pressure and ouabain binding (r = -0.58, p less than 0.01, r = -0.51, p less than 0.01, or r = -0.55, p less than 0.01, respectively).

  1. A rightly balanced intellectual property rights regime as a mechanism to enhance commercial earth observation activities

    Science.gov (United States)

    Doldirina, Catherine

    2010-09-01

    Earth observation by satellites is one of the developing sectors of space activities with the growing involvement in private capital or actors. This leads to the question of how efficient legal rules governing this activity are. Copyright law is one of the key fields of law applicable to earth observation activities and is the subject of the present analysis. This paper describes the current state of copyright regulations in different jurisdictions. It also addresses the issue of defining earth observation data for the purpose of applying copyright protection to them. Finally, it analyses whether more or less copyright protection would be beneficial for the commercialisation of the earth observation activities, and the distribution and further use of data they produce. The paper is largely based on my current doctoral research. Draft chapter on file with the author.

  2. The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity.

    Science.gov (United States)

    Bowen, David G; Zen, Monica; Holz, Lauren; Davis, Thomas; McCaughan, Geoffrey W; Bertolino, Patrick

    2004-09-01

    Hepatic immunobiology is paradoxical: although the liver possesses unusual tolerogenic properties, it is also the site of effective immune responses against multiple pathogens and subject to immune-mediated pathology. The mechanisms underlying this dichotomy remain unclear. Following previous work demonstrating that the liver may act as a site of primary T cell activation, we demonstrate here that the balance between immunity and tolerance in this organ is established by competition for primary activation of CD8+ T cells between the liver and secondary lymphoid tissues, with the immune outcome determined by the initial site of activation. Using a transgenic mouse model in which antigen is expressed within both liver and lymph nodes, we show that while naive CD8+ T cells activated within the lymph nodes were capable of mediating hepatitis, cells undergoing primary activation within the liver exhibited defective cytotoxic function and shortened half-life and did not mediate hepatocellular injury. The implications of these novel findings may pertain not only to the normal maintenance of peripheral tolerance, but also to hepatic allograft tolerance and the immunopathogenesis of chronic viral hepatitis.

  3. A semi-immersive virtual reality incremental swing balance task activates prefrontal cortex: a functional near-infrared spectroscopy study.

    Science.gov (United States)

    Basso Moro, Sara; Bisconti, Silvia; Muthalib, Makii; Spezialetti, Matteo; Cutini, Simone; Ferrari, Marco; Placidi, Giuseppe; Quaresima, Valentina

    2014-01-15

    Previous functional near-infrared spectroscopy (fNIRS) studies indicated that the prefrontal cortex (PFC) is involved in the maintenance of the postural balance after external perturbations. So far, no studies have been conducted to investigate the PFC hemodynamic response to virtual reality (VR) tasks that could be adopted in the field of functional neurorehabilitation. The aim of this fNIRS study was to assess PFC oxygenation response during an incremental and a control swing balance task (ISBT and CSBT, respectively) in a semi-immersive VR environment driven by a depth-sensing camera. It was hypothesized that: i) the PFC would be bilaterally activated in response to the increase of the ISBT difficulty, as this cortical region is involved in the allocation of attentional resources to maintain postural control; and ii) the PFC activation would be greater in the right than in the left hemisphere considering its dominance for visual control of body balance. To verify these hypotheses, 16 healthy male subjects were requested to stand barefoot while watching a 3 dimensional virtual representation of themselves projected onto a screen. They were asked to maintain their equilibrium on a virtual blue swing board susceptible to external destabilizing perturbations (i.e., randomizing the forward-backward direction of the impressed pulse force) during a 3-min ISBT (performed at four levels of difficulty) or during a 3-min CSBT (performed constantly at the lowest level of difficulty of the ISBT). The center of mass (COM), at each frame, was calculated and projected on the floor. When the subjects were unable to maintain the COM over the board, this became red (error). After each error, the time required to bring back the COM on the board was calculated (returning time). An eight-channel continuous wave fNIRS system was employed for measuring oxygenation changes (oxygenated-hemoglobin, O2Hb; deoxygenated-hemoglobin, HHb) related to the PFC activation (Brodmann Areas 10, 11

  4. Active video-gaming effects on balance and mobility in individuals with chronic stroke: a randomized controlled trial.

    Science.gov (United States)

    Fritz, Stacy L; Peters, Denise M; Merlo, Angela M; Donley, Jonathan

    2013-01-01

    Treatments that provide feedback, increase practice with multiple repetitions, and motivate patients are essential to rehabilitation post stroke. To determine whether playing active video games results in improved balance and mobility post stroke. Thirty participants with chronic (time since stroke = 3.0 [2.9] years) hemiparesis post stroke were randomly assigned to a gaming group or normal activity control group. Gaming systems provided participants with an interactive interface of real-time movement of either themselves or an avatar on the screen. Participants played games 50-60 minutes/day, 4 days/week, for 5 weeks. The intervention was strictly game-play, in standing position, without physical therapy. The control group received no special intervention and continued with normal activity. Both groups were tested prior to, following the 5 weeks (post test), and 3 months following the completion of the study. Outcome measures included the Fugl-Meyer Assessment, Berg Balance Scale, Dynamic Gait Index, Timed Up & Go, 6-minute walk test, 3-meter walk (self-selected and fast), and perception of recovery. No statistically significant differences between or within groups were found through analysis of covariance (covaried for side of hemiparesis) at post test or follow-up. Although the within-group effect sizes were primarily indexed as "small" (gaming group exhibited higher within-group effect sizes before and after testing than did the control group on all 7 dependent variables analyzed. Even though the only intervention was game-play, there were small positive effects. Therapist assistance in making more optimum movement choices may be needed before significant improvements are seen with commercially available, general purpose games.

  5. Impact of active and break wind spells on the demand-supply balance in wind energy in India

    Science.gov (United States)

    Kulkarni, Sumeet; Deo, M. C.; Ghosh, Subimal

    2018-02-01

    With an installed capacity of over 19,000 MW, the wind power currently accounts for almost 70% of the total installed capacity among the renewable energy sector in India. The extraction of wind power mainly depends on prevailing meteorology which is strongly influenced by monsoon variability. The monsoon season is characterized by significant fluctuations in between periods of wet and dry spells. During the dry spells, the demand for power from agriculture and cooling equipment increases, whereas during the wet periods, such demand reduces, although, at the same time, the power supply increases because of strong westerly winds contributing to an enhanced production of wind energy. At this backdrop, we aim to assess the impact of intra-seasonal wind variability on the balance of energy supply and demand during monsoon seasons in India. Further, we explore the probable cause of wind variability by relating it to El Nino events. It is observed that the active and break phases in wind significantly impact the overall wind potential output. Although the dry spells are generally found to reduce the overall wind potential, their impact on the potential seems to have declined after the year 2000. The impact of meteorological changes on variations in wind power studied in this work should find applications typically in taking investment decisions on conventional generation facilities, like thermal, which are currently used to maintain the balance of power supply and demand.

  6. Improvement of the in vivo cellular repopulation of decellularized cardiovascular tissues by a detergent-free, non-proteolytic, actin-disassembling regimen.

    Science.gov (United States)

    Assmann, Alexander; Struß, Marc; Schiffer, Franziska; Heidelberg, Friederike; Munakata, Hiroshi; Timchenko, Elena V; Timchenko, Pavel E; Kaufmann, Tim; Huynh, Khon; Sugimura, Yukiharu; Leidl, Quentin; Pinto, Antonio; Stoldt, Volker R; Lichtenberg, Artur; Akhyari, Payam

    2017-12-01

    Low immunogenicity and high repopulation capacity are crucial determinants for the functional and structural performance of acellular cardiovascular implants. The present study evaluates a detergent-free, non-proteolytic, actin-disassembling regimen (BIO) for decellularization of heart valve and vessel grafts, particularly focusing on their bio-functionality. Rat aortic conduits (rAoC; n = 89) and porcine aortic valve samples (n = 106) are decellularized using detergents (group DET) or the BIO regimen. BIO decellularization results in effective elimination of cellular proteins and significantly improves removal of DNA as compared with group DET, while the extracellular matrix (ECM) structure as well as mechanical properties are preserved. The architecture of rAoC in group BIO allows for improved bio-functionalization with fibronectin (FN) in a standardized rat implantation model: BIO treatment significantly increases speed and amount of autologous medial cellular repopulation in vivo (p < 0.001) and decreases the formation of hyperplastic intima (p < 0.001) as compared with FN-coated DET-decellularized grafts. Moreover, there are no signs of infiltration with inflammatory cells. The present biological, detergent-free, non-proteolytic regimen balances effective decellularization and ECM preservation in cardiovascular grafts, and provides optimized bio-functionality. Additionally, this study implies that the actin-disassembling regimen may be a promising approach for bioengineering of acellular scaffolds from other muscular tissues, as for example myocardium or intestine. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  7. Atypical Balance between Occipital and Fronto-Parietal Activation for Visual Shape Extraction in Dyslexia

    Science.gov (United States)

    Zhang, Ying; Whitfield-Gabrieli, Susan; Christodoulou, Joanna A.; Gabrieli, John D. E.

    2013-01-01

    Reading requires the extraction of letter shapes from a complex background of text, and an impairment in visual shape extraction would cause difficulty in reading. To investigate the neural mechanisms of visual shape extraction in dyslexia, we used functional magnetic resonance imaging (fMRI) to examine brain activation while adults with or without dyslexia responded to the change of an arrow’s direction in a complex, relative to a simple, visual background. In comparison to adults with typical reading ability, adults with dyslexia exhibited opposite patterns of atypical activation: decreased activation in occipital visual areas associated with visual perception, and increased activation in frontal and parietal regions associated with visual attention. These findings indicate that dyslexia involves atypical brain organization for fundamental processes of visual shape extraction even when reading is not involved. Overengagement in higher-order association cortices, required to compensate for underengagment in lower-order visual cortices, may result in competition for top-down attentional resources helpful for fluent reading. PMID:23825653

  8. Single-Phase Single-Stage Grid Tied Solar PV System with Active Power Filtering Using Power Balance Theory

    Science.gov (United States)

    Singh, Yashi; Hussain, Ikhlaq; Singh, Bhim; Mishra, Sukumar

    2018-03-01

    In this paper, power quality features such as harmonics mitigation, power factor correction with active power filtering are addressed in a single-stage, single-phase solar photovoltaic (PV) grid tied system. The Power Balance Theory (PBT) with perturb and observe based maximum power point tracking algorithm is proposed for the mitigation of power quality problems in a solar PV grid tied system. The solar PV array is interfaced to a single phase AC grid through a Voltage Source Converter (VSC), which provides active power flow from a solar PV array to the grid as well as to the load and it performs harmonics mitigation using PBT based control. The solar PV array power varies with sunlight and due to this, the solar PV grid tied VSC works only 8-10 h per day. At night, when PV power is zero, the VSC works as an active power filter for power quality improvement, and the load active power is delivered by the grid to the load connected at the point of common coupling. This increases the effective utilization of a VSC. The system is modelled and simulated using MATLAB and simulated responses of the system at nonlinear loads and varying environmental conditions are also validated experimentally on a prototype developed in the laboratory.

  9. On the origin of muscle synergies: invariant balance in the co-activation of agonist and antagonist muscle pairs

    Directory of Open Access Journals (Sweden)

    Hiroaki eHirai

    2015-11-01

    Full Text Available Investigation of neural representation of movement planning has attracted the attention of neuroscientists, as it may reveal the sensorimotor transformation essential to motor control. The analysis of muscle synergies based on the activity of agonist-antagonist (AA muscle pairs may provide insight into such transformations, especially for a reference frame in the muscle space. In this study, we examined the AA concept using the following explanatory variables: the AA ratio, which is related to the equilibrium-joint angle, and the AA sum, which is associated with joint stiffness. We formulated muscle synergies as a function of AA sums, positing that muscle synergies are composite units of mechanical impedance. The AA concept can be regarded as another form of the equilibrium-point (EP hypothesis, and it can be extended to the concept of EP-based synergies. We introduce here a novel tool for analyzing the neurological and motor functions underlying human movements and review some initial insights from our results about the relationships between muscle synergies, endpoint stiffness, and virtual trajectories (time series of EP. Our results suggest that (1 muscle synergies reflect an invariant balance in the co-activation of AA muscle pairs; (2 each synergy represents the basis for the radial, tangential, and null movements of the virtual trajectory in the polar coordinates centered on the specific joint at the base of the body; and (3 the alteration of muscle synergies (for example, due to spasticity or rigidity following neurological injury results in significant distortion of endpoint stiffness and concomitant virtual trajectories. These results indicate that muscle synergies (i.e., the balance of muscle mechanical impedance are essential for motor control.

  10. On the Origin of Muscle Synergies: Invariant Balance in the Co-activation of Agonist and Antagonist Muscle Pairs.

    Science.gov (United States)

    Hirai, Hiroaki; Miyazaki, Fumio; Naritomi, Hiroaki; Koba, Keitaro; Oku, Takanori; Uno, Kanna; Uemura, Mitsunori; Nishi, Tomoki; Kageyama, Masayuki; Krebs, Hermano Igo

    2015-01-01

    Investigation of neural representation of movement planning has attracted the attention of neuroscientists, as it may reveal the sensorimotor transformation essential to motor control. The analysis of muscle synergies based on the activity of agonist-antagonist (AA) muscle pairs may provide insight into such transformations, especially for a reference frame in the muscle space. In this study, we examined the AA concept using the following explanatory variables: the AA ratio, which is related to the equilibrium-joint angle, and the AA sum, which is associated with joint stiffness. We formulated muscle synergies as a function of AA sums, positing that muscle synergies are composite units of mechanical impedance. The AA concept can be regarded as another form of the equilibrium-point (EP) hypothesis, and it can be extended to the concept of EP-based synergies. We introduce, here, a novel tool for analyzing the neurological and motor functions underlying human movements and review some initial insights from our results about the relationships between muscle synergies, endpoint stiffness, and virtual trajectories (time series of EP). Our results suggest that (1) muscle synergies reflect an invariant balance in the co-activation of AA muscle pairs; (2) each synergy represents the basis for the radial, tangential, and null movements of the virtual trajectory in the polar coordinates centered on the specific joint at the base of the body; and (3) the alteration of muscle synergies (for example, due to spasticity or rigidity following neurological injury) results in significant distortion of endpoint stiffness and concomitant virtual trajectories. These results indicate that muscle synergies (i.e., the balance of muscle mechanical impedance) are essential for motor control.

  11. Interactive domains in the molecular chaperone human alphaB crystallin modulate microtubule assembly and disassembly.

    Directory of Open Access Journals (Sweden)

    Joy G Ghosh

    2007-06-01

    Full Text Available Small heat shock proteins regulate microtubule assembly during cell proliferation and in response to stress through interactions that are poorly understood.Novel functions for five interactive sequences in the small heat shock protein and molecular chaperone, human alphaB crystallin, were investigated in the assembly/disassembly of microtubules and aggregation of tubulin using synthetic peptides and mutants of human alphaB crystallin.The interactive sequence (113FISREFHR(120 exposed on the surface of alphaB crystallin decreased microtubule assembly by approximately 45%. In contrast, the interactive sequences, (131LTITSSLSSDGV(142 and (156ERTIPITRE(164, corresponding to the beta8 strand and the C-terminal extension respectively, which are involved in complex formation, increased microtubule assembly by approximately 34-45%. The alphaB crystallin peptides, (113FISREFHR(120 and (156ERTIPITRE(164, inhibited microtubule disassembly by approximately 26-36%, and the peptides (113FISREFHR(120 and (131LTITSSLSSDGV(142 decreased the thermal aggregation of tubulin by approximately 42-44%. The (131LTITSSLSSDGV(142 and (156ERTIPITRE(164 peptides were more effective than the widely used anti-cancer drug, Paclitaxel, in modulating tubulinmicrotubule dynamics. Mutagenesis of these interactive sequences in wt human alphaB crystallin confirmed the effects of the alphaB crystallin peptides on microtubule assembly/disassembly and tubulin aggregation. The regulation of microtubule assembly by alphaB crystallin varied over a narrow range of concentrations. The assembly of microtubules was maximal at alphaB crystallin to tubulin molar ratios between 1:4 and 2:1, while molar ratios >2:1 inhibited microtubule assembly.Interactive sequences on the surface of human alphaB crystallin collectively modulate microtubule assembly through a dynamic subunit exchange mechanism that depends on the concentration and ratio of alphaB crystallin to tubulin. These are the first

  12. [PHAHs levels in soil samples from the E-waste disassembly sites and their sources allocation].

    Science.gov (United States)

    Zhao, Gao-Feng; Wang, Zi-Jian

    2009-06-15

    Soil samples (each with 3 replicates of - 1 kg, at the top 0-5 cm layer) were collected from each of the e-waste disassembly sites and the control site. Also obtained from each disassembly site were samples (each weighing - 0.2 kg) of cable coating,stuffing powder, and circuit boards chipping. The contents of 23 PBB congeners, 12 PBDE congeners, and 27 PCB congeners in soil and in their potential sources, including e-waste residues, were measured using the GC-MS5975B technique. The highest level of PBBs was found in the cable coating among the three e-waste residues, with a concentration of 35.25 ng x g(-1). The contents of low-brominated PBBs (including monobromobiphenyls and dibromobiphenyls) accounted for 38% of the total PBBs concentration observed in cable coating sample. The highest levels of PBDEs and PBDE209 were found in the stuffing powder for electronic component among the collected e-waste residues, with a concentration of 29.71 and 4.19 x 10(3) ng x g(-1). PBDE153 and PBDE183 were the most predominant PBDE congeners, with their concentration accounting for 43% and 24% of the total PBDEs concentration observed in the stuffing powder sample, respectively. Levels of PCBs in cable coating were the highest in these e-waste residues, with a concentration of 680.02 ngx g(-1). The observed values of the three PHAHs in soils from the disassembly site were considerably higher than their corresponding values observed in the control site (p < 0.05), which indicates that these PHAHs from e-waste is the pollution source of local environment.

  13. Development of disassembly and pin chopping technology for FBR spent fuels

    International Nuclear Information System (INIS)

    Kobayashi, Tsuguyuki; Namba, Takashi; Kawabe, Yukinari; Washiya, Tadahiro

    2008-01-01

    Japan Atomic Power Company (JAPC) and Japan Atomic Energy Agency (JAEA) have been developing fuel disassembly and fuel pin chopping systems for a future Japanese commercial FBR. At first, the wrapper tube is cut by the slit-cut to pull it out, then the fuel pins are cut by the crop-cut at their end-plugs to separate them from the entrance nozzle. The pins are transferred to the magazine of the chopping machine. A series of tests were performed to develop this procedure. As the result of mechanical cutting tests, the CBN wheel was selected. The slit-cut tests were carried out to evaluated the cutting performance of the wheel. The wrapper tube is normally slit-cut in the circumferential direction. One CBN wheel could cut more than 5 fuel assemblies in this direction. The slit-cut in the axial direction is prepared as provision when the tube is difficult to put out. More work is needed to cut 5mm thick PNC-FMS plate in this direction without damaging the pins beneath it. As the result of the crop-cut tests of end-plugs made of ODS steel, the CBN wheel could cut the 61 pin bundle by two strokes. More work is needed to cut the 217 pin bundle. Fuel pin handling tests were performed to transfer them from the disassembly machine to the chopping machine. The Saucer tray was selected to receive the disassembled pins. All the pins were transferred and loaded into a magazine of the chopping machine. Fuel pin loading tests were conducted to optimize the magazine configuration to make the chopping length within 1.0±0.5 cm. In order to decrease the disturbance during chopping, the width of the magazine was adjusted to be 12 cm and installation of a height adjuster is favourable to control the free space above the pins. (author)

  14. A Novel Active Online State of Charge Based Balancing Approach for Lithium-Ion Battery Packs during Fast Charging Process in Electric Vehicles

    Directory of Open Access Journals (Sweden)

    Xiudong Cui

    2017-11-01

    Full Text Available Abstract: Non-uniformity of Lithium-ion cells in a battery pack is inevitable and has become the bottleneck to the pack capacity, especially in the fast charging process. Therefore, a balancing approach is essentially required. This paper proposes an active online cell balancing approach in a fast charging process using the state of charge (SOC as balancing criterion. The goal of this approach is to complete pack balancing within the limited charging time. An adaptive extended Kalman filter (AEKF is applied to estimate the pack cell SOC during the charging process to obtain accurate results under modeling errors and measurement noises. To implement the proposed AEKF, only one additional current sensor is required to obtain the current of each cell required for the SOC estimation. An experimental platform is established to verify the effectiveness of the proposed approach. The results show that the proposed balancing approach with the SOC as a balancing criterion can overcome the challenges of non-uniformity and flat voltage plateau and charge more capacity into a LiFePO4 battery pack than those with the terminal voltage as a balancing criterion in the fast charging process.

  15. A Standing Location Detector Enabling People with Developmental Disabilities to Control Environmental Stimulation through Simple Physical Activities with Nintendo Wii Balance Boards

    Science.gov (United States)

    Shih, Ching-Hsiang

    2011-01-01

    This study evaluated whether two people with developmental disabilities would be able to actively perform simple physical activities by controlling their favorite environmental stimulation using Nintendo Wii Balance Boards with a newly developed standing location detection program (SLDP, i.e., a new software program turning a Nintendo Wii Balance…

  16. KADIS: a program to analyse the disassembly phase of hypothetical accidents in LMFBRs

    International Nuclear Information System (INIS)

    Schmuck, P.; Jacobs, G.; Arnecke, G.

    1977-11-01

    The program KADIS models the disassembly phase during power excursions in LMFBR hypothetical accidents. KADIS is based on point kinetics in the neutronics part and on a 2-dimensional representation of the reactor core in the hydrodynamics part. The core is modeled as an ideal, compressible fluid which is heated up adiabatically during the excursion. KADIS was built up with the help of the VENUS program of Argonne National Laboratory. Several important features were added to the basic VENUS model. Therefore we give first a complete description of the mathematical models used. Secondly we provide the user with the necessary information to handle the input/output of KADIS. (orig.) [de

  17. Engineering scale tests of mechanical disassembly and short stroke shearing systems for FBR fuel assembly

    International Nuclear Information System (INIS)

    Higuchi, Hidetoshi; Kitagaki, Toru; Koizumi, Kenji; Hirano, Hiroyasu; Takeuchi, Masayuki; Washiya, Tadahiro; Kawabe, Yukinari; Kobayashi, Tsuguyuki

    2011-01-01

    Japan Atomic Energy Agency (JAEA) and The Japan Atomic Power Company (JAPC) have been developing an advanced head-end process based on mechanical disassembly and short stroke shearing systems as a part of Fast Reactor Cycle Technology Development (FaCT). Fuel pins for a fast reactor are installed within a hexagonal shaped wrapper tube made of stainless steel. In order to reprocess the fast reactor fuel pins, they must be removed from the wrapper tube and transported to the shearing system without failure. In addition, the advanced aqueous reprocessing process, called 'NEXT' (New Extraction System for TRU Recovery) process requires a solution of the spent fuel with relatively high concentration (500g/L). JAEA and JAPC have developed the mechanical disassembly and the short stroke shearing technology which is expected to make fragmented fuel to satisfy these requirements. This paper reports the results of engineering scale tests on the mechanical disassembly and short stroke shearing systems. These tests were carried out with simulated FBR fuel assembly and removed pins. The mechanical cutting method has been developed to avoid fuel pin failure during disassembly operation. The cutting process is divided into two modes, so called 'slit-cut' for cutting the wrapper tube and 'crop-cut' for the end plug region of the fuel pin bundle. In the slit-cut mode, the depth of cutting was automatically controlled based on the calculated wastage of the cutting tool and deformation of the wrapper tube which had been measured before the cutting. This procedure was confirmed to minimize the fuel pin failure which was hard to prevent in the case of laser cutting. The cutting speed was also controlled automatically by the electric current of the cutting motor to lower the load of the cutting tool. The removed fuel pins were transported to the shearing machine, whose fuel shearing magazine width was set to be narrow to realize the suitable configuration for the short stroke shearing

  18. Nuclear disassembly of the (Pb+Au) system at Elab=29 MeV per nucleon

    International Nuclear Information System (INIS)

    Piasecki, E.; Kordyasz, A.; Bresson, S.; Crema, E.; Galin, J.; Guerreau, D.; Morjean, M.; Paulot, C.; Pouthas, J.; Jastrzebski, J.; Pienkowski, L.; Skulski, W.; Lott, B.; Quednau, B.; Schroder, W.U.; Toeke, J.

    1990-01-01

    Nuclei, with Z up to 82, emitted in the 208 Pb+ 197 Au reaction at E lab =29 MeV per nucleon, have been measured as a function of the associated neutron multiplicity. The data reveal the presence of strong correlations between character of a collision and neutron multiplicity. The trends suggest a disassembly of the nuclear system into a large number of nucleons and small fragments in the events with the highest neutron multiplicity. In such events, approximately one third of the neutrons are released from the system and fragments yields decrease in an exponential fashion with increasing mass

  19. Psychometric Properties of Persian Translated Version of Activities-specific Balance Confidence Scale (ABC in Arak Community-dwelling Older Adults

    Directory of Open Access Journals (Sweden)

    Daryoush Khajavi

    2017-11-01

    Full Text Available Abstract Background: Balance deficiency, falls and fear of fall are important problems that can resulted in reversed health outcomes including decreased quality of life. The purpose of this study was surveying factor structure, validation, and reliability determination of Persian translated version of Activities-specific Balance Confidence scale in community-dwelling older adults of Arak city. Materials and Methods: Research method was descriptive in form of psychometry. The statistic population was older adults of Arak in year 2012 and 308 subjects with mean age 69.38 years were selected availably. Data were collected by Persian translated version of Activities-specific Balance Confidence that is a 16-item scale and evaluates balance confidence in activities of daily living. Data were analyzed by Exploratory Factor Analysis. Test-retest and internal reliability were calculated by Pearson correlation coefficient and Chronbach’s Alpha. Data were analyzed with SPSS-16. Results: The findings resulted in extraction of one factor with eigenvalue over one that explained 82.89% of total variance. Test-retest reliability between 1 to 4 weeks and internal reliability (Chronbach’s alpha were 0.82 and 0.98, respectively. Gutmann split-half correlation coefficient and intra-class correlation coefficient were calculated 95% and 85%, respectively. Conclusion: Persian translated version of Activities-specific Balance Confidence (ABC-F is a valid and reliable tool for Iranian community-dwelling older adults that can be used in clinical and research purpose.

  20. Impact of physical activity on balance in people over 65 years of age

    Directory of Open Access Journals (Sweden)

    Justyna Rak

    2017-07-01

    Full Text Available The cause of aging society is the significant prolongation of life expectancy. With the aging process, there is progressive and permanent decrease in functional reserves and deterioration of homeostasis control. [1,2,3,4] By degenerative changes, there is imbalance and hence the frequency of falls, and therefore regular physical activity is important to restore, maintain, and maintain independence. [3,4,5,6] The study was performed by a patient aged 86, 56 kg and a height of 149 cm. Equilibrium assessment was performed using static posturography and the Four Squar Step Test (FSST before and after a 10-day rehabilitation session under the supervision of a physiotherapist. The results of the exercise were improved in the test and posturography test with open eyes, while deterioration was indicated in the eyes with closed eyes.

  1. A Study of The Effect of Preschool Children's Participation in Sensorimotor Activities on Their Understanding of the Mechanical Equilibrium of a Balance Beam

    Science.gov (United States)

    Hadzigeorgiou, Yannis; Anastasiou, Leonidas; Konsolas, Manos; Prevezanou, Barbara

    2009-01-01

    The purpose of this study was to investigate whether participation in sensorimotor activities by preschool children involving their own bodily balance while walking on a beam over the floor has an effect on their understanding of the mechanical equilibrium of a balance beam. The balance beam consisted of a horizontal stick balancing around its center of mass (middle point), while carrying equal-weight objects on either side of it. The study utilized a two-group design, and was conducted in three phases (pre-test, treatment and post-test). The results of the study provide evidence that there was such an effect, since the children (who participated in the sensorimotor activities) could select out of a number of objects those two with the same weight regardless of their shape, size or colour, in order to balance the stick. This effect also can be seen when a comparison is made with a second group of children, which had previously participated in a hands-on activity regarding the equilibrium of a similar balance beam, and which (children), therefore, had a definite advantage over the other children who had participated in the sensorimotor activity. A Chi Square Test showed no significant differences between the two groups on both an immediate and a delayed post-test, while the McNemar Test for the Significance of Change showed a statistically significant difference (that is, a negative change in performance between the first and the second post-test) only within the hands-on group. This difference represents evidence that the children from the sensorimotor group remembered better the rule they were applying (i.e., selecting equal-weight objects) in order to balance the beam.

  2. Roles of cell adhesion and cytoskeleton activity in Entamoeba histolytica pathogenesis: a delicate balance.

    Science.gov (United States)

    Tavares, Paulo; Rigothier, Marie-Christine; Khun, Huot; Roux, Pascal; Huerre, Michel; Guillén, Nancy

    2005-03-01

    The protozoan parasite Entamoeba histolytica colonizes the human large bowel. Invasion of the intestinal epithelium causes amoebic colitis and opens the route for amoebic liver abscesses. The parasite relies on its dynamic actomyosin cytoskeleton and on surface adhesion molecules for dissemination in the human tissues. Here we show that the galactose/N-acetylgalactosamine (Gal/GalNAc) lectin clusters in focal structures localized in the region of E. histolytica that contacts monolayers of enterocytes. Disruption of myosin II activity impairs the formation of these structures and renders the trophozoites avirulent for liver abscess development. Production of the cytoplasmic domain of the E. histolytica Gal/GalNAc lectin in engineered trophozoites causes reduced adhesion to enterocytes. Intraportal delivery of these parasites to the liver leads to the formation of a large number of small abscesses with disorganized morphology that are localized in the vicinity of blood vessels. The data support a model for invasion in which parasite motility is essential for establishment of infectious foci, while the adhesion to host cells modulates the distribution of trophozoites in the liver and their capacity to migrate in the hepatic tissue.

  3. Beta-adrenergic receptor sensitivity, autonomic balance and serotonergic activity in practitioners of Transcendental Meditation

    International Nuclear Information System (INIS)

    Hill, D.A.

    1989-01-01

    The aim of this thesis was to investigate the acute autonomic effects of the Transcendental Meditation Program (TM) and resolve the conflict arising from discrepant neurochemical and psychophysiological data. Three experimental investigations were performed. The first examined beta 2 -adrenergic receptors (AR's) on peripheral blood lymphocytes, via [I 125 ]iodocyanopindolol binding, in 10 male mediating and 10 age matched non-meditating control subjects, to test the hypothesis that the long-term practice of TM and the TM Sidhi Program (TMSP) reduces end organ sensitivity to adrenergic agonists. The second investigated respiratory sinus arrhythmia (an indirect measure of cardiac Parasympathetic Nervous System tone), and skin resistance (a measure of Sympathetic Nervous System tone) during periods of spontaneous respiratory apneusis, a phenomenon occurring during TM that is known to mark the subjective experience of transcending. The third was within subject investigation of the acute effects of the TMSP on 5-hydroxytryptamine (5-HT) activity. Platelet 5-HT was assayed by high pressure liquid chromatography with electrochemical detection, plasma prolactin (PL) and lutenizing hormone (LH) by radioimmunoassay, tryptophan by spectrofluorimetry, and alpha-1-acid glycoprotein (AGP, a modulator of 5-HT uptake) by radial immunodiffusion assay

  4. NCI Funding Trends and Priorities in Physical Activity and Energy Balance Research Among Cancer Survivors.

    Science.gov (United States)

    Alfano, Catherine M; Bluethmann, Shirley M; Tesauro, Gina; Perna, Frank; Agurs-Collins, Tanya; Elena, Joanne W; Ross, Sharon A; O'Connell, Mary; Bowles, Heather R; Greenberg, Deborah; Nebeling, Linda

    2016-01-01

    There is considerable evidence that a healthy lifestyle consisting of physical activity, healthy diet, and weight control is associated with reduced risk of morbidity and mortality after cancer. However, these behavioral interventions are not widely adopted in practice or community settings. Integrating heath behavior change interventions into standard survivorship care for the growing number of cancer survivors requires an understanding of the current state of the science and a coordinated scientific agenda for the future with focused attention in several priority areas. To facilitate this goal, this paper presents trends over the past decade of the National Cancer Institute (NCI) research portfolio, fiscal year 2004 to 2014, by funding mechanism, research focus, research design and methodology, primary study exposures and outcomes, and study team expertise and composition. These data inform a prioritized research agenda for the next decade focused on demonstrating value and feasibility and creating desire for health behavior change interventions at multiple levels including the survivor, clinician, and healthcare payer to facilitate the development and implementation of appropriately targeted, adaptive, effective, and sustainable programs for all survivors. Published by Oxford University Press (2015). This work is written by (a) US Government employee(s) and is in the public domain in the US.

  5. Influence of secondary settling tank performance on suspended solids mass balance in activated sludge systems.

    Science.gov (United States)

    Patziger, M; Kainz, H; Hunze, M; Józsa, J

    2012-05-01

    Secondary settling is the final step of the activated sludge-based biological waste water treatment. Secondary settling tanks (SSTs) are therefore an essential unit of producing a clear effluent. A further important function of SSTs is the sufficient thickening to achieve highly concentrated return sludge and biomass within the biological reactor. In addition, the storage of activated sludge is also needed in case of peak flow events (Ekama et al., 1997). Due to the importance of a high SST performance the problem has long been investigated (Larsen, 1977; Krebs, 1991; Takács et al., 1991; Ekama et al., 1997; Freimann, 1999; Patziger et al., 2005; Bürger et al., 2011), however, a lot of questions are still to solve regarding e.g. the geometrical features (inflow, outflow) and operations (return sludge control, scraper mechanism, allowable maximum values of surface overflow rates). In our study we focused on SSTs under dynamic load considering both the overall unsteady behaviour and the features around the peaks, investigating the effect of various sludge return strategies as well as the inlet geometry on SST performance. The main research tool was a FLUENT-based novel mass transport model consisting of two modules, a 2D axisymmetric SST model and a mixed reactor model of the biological reactor (BR). The model was calibrated and verified against detailed measurements of flow and concentration patterns, sludge settling, accompanied with continuous on-line measurement of in- and outflow as well as returned flow rates of total suspended solids (TSS) and water. As to the inlet arrangement a reasonable modification of the geometry could result in the suppression of the large scale flow structures of the sludge-water interface thus providing a significant improvement in the SST performance. Furthermore, a critical value of the overflow rate (q(crit)) was found at which a pronounced large scale circulation pattern develops in the vertical plane, the density current in

  6. Prey and mound disassembly, manipulation and transport by fire ant collectives

    Science.gov (United States)

    Dutta, Bahnisikha; Monaenkova, Daria; Goodisman, Michael A.; Goldman, Daniel

    Fire ants inhabit subterranean nests covered by a hemispherical mound of soil permeated by narrow ( 1 body length diameter) tunnels. Fire ants can use their mound for long-term food storage [Gayahan &Tschinkel, J. Insect Sci.,2008]. Since mound tunnels are narrow, we expect that in addition to prey manipulation, mound reconfiguration could also be an important aspect of the food storage strategy. Ant colonies collected from wild were allowed to build nests in containers filled with clay soil in the laboratory. These colonies were offered diverse prey embedded with lead markers, including mealworms, crickets and shrimp. Ant-prey-soil interactions on the nest surface were recorded using overhead video and subsurface using x-ray imaging. Individual ants involved in prey storage exhibited three distinct behaviors: prey maneuvering, prey dissection and mound reconfiguration. Small prey (e.g. mealworms) were collectively carried intact into the mound through a tunnel, and then disassembled within the mound. Larger prey (e.g. shrimp) were dismantled into small pieces above the surface and carried to mound tunnels. The bodies of hard medium-sized prey (e.g. crickets) were buried after limb removal and then disassembled and moved into tunnels. Soil reconfiguration occurred in all cases.

  7. Plastics disassembly versus bulk recycling: engineering design for end-of-life electronics resource recovery.

    Science.gov (United States)

    Rios, Pedro; Stuart, Julie Ann; Grant, Ed

    2003-12-01

    Annual plastic flows through the business and consumer electronics manufacturing supply chain include nearly 3 billion lb of high-value engineering plastics derived from petroleum. The recovery of resource value from this stream presents critical challenges in areas of materials identification and recycling process design that demand new green engineering technologies applied together with life cycle assessment and ecological supply chain analysis to create viable plastics-to-plastics supply cycles. The sustainable recovery of potentially high-value engineering plastics streams requires that recyclers either avoid mixing plastic parts or purify later by separating smaller plastic pieces created in volume reduction (shredding) steps. Identification and separation constitute significant barriers in the plastics-to-plastics recycling value proposition. In the present work, we develop a model that accepts randomly arriving electronic products to study scenarios by which a recycler might identify and separate high-value engineering plastics as well as metals. Using discrete eventsimulation,we compare current mixed plastics recovery with spectrochemical plastic resin identification and subsequent sorting. Our results show that limited disassembly with whole-part identification can produce substantial yields in separated streams of recovered engineering thermoplastics. We find that disassembly with identification does not constitute a bottleneck, but rather, with relatively few workers, can be configured to pull the process and thus decrease maximum staging space requirements.

  8. Stimuli-disassembling gold nanoclusters for diagnosis of early stage oral cancer by optical coherence tomography

    Science.gov (United States)

    Kim, Chang Soo; Ingato, Dominique; Wilder-Smith, Petra; Chen, Zhongping; Kwon, Young Jik

    2018-01-01

    A key design consideration in developing contrast agents is obtaining distinct, multiple signal changes in diseased tissue. Plasmonic gold nanoparticles (Au NPs) have been developed as contrast agents due to their strong surface plasmon resonance (SPR). This study aims to demonstrate that stimuli-responsive plasmonic Au nanoclusters (Au NCs) can be used as a contrast agent for optical coherence tomography (OCT) in detecting early-stage cancer. Au NPs were clustered via acid-cleavable linkers to synthesize Au NCs that disassemble under mildly acidic conditions into individual Au NPs, simultaneously diminishing SPR effect (quantified by scattering intensity) and increasing Brownian motion (quantified by Doppler variance). The acid-triggered morphological and accompanying optico-physical property changes of the acid-disassembling Au NCs were confirmed by TEM, DLS, UV/Vis, and OCT. Stimuli-responsive Au NCs were applied in a hamster check pouch model carrying early-stage squamous carcinoma tissue. The tissue was visualized by OCT imaging, which showed reduced scattering intensity and increased Doppler variance in the dysplastic tissue. This study demonstrates the promise of diagnosing early-stage cancer using molecularly programmable, inorganic nanomaterial-based contrast agents that are capable of generating multiple, stimuli-triggered diagnostic signals in early-stage cancer.[Figure not available: see fulltext.

  9. Assessment of the impacts of spent fuel disassembly alternatives on the Nuclear Waste Isolation System

    International Nuclear Information System (INIS)

    1984-07-01

    The objective of this report was to evaluate four possible alternative methods of preparing and packaging spent fuel assemblies for geologic disposal against the Reference Process of unmodified spent fuel. The four alternative processes were: (1) End fitting removal, (2) Fission gas venting and resealing, (3) Fuel bundle disassembly and close packing of fuel pins, and (4) Fuel shearing and immobilization. Systems analysis was used to develop a basis of comparison of the alternatives. Conceptual processes and facility layouts were devised for each of the alternatives, based on technology deemed feasible for the purpose. Assessments were made of 15 principal attributes from the technical, operational, safety/risk, and economic considerations related to each of the alternatives, including both the surface packaging and underground repository operations. Specific attributes of the alternative processes were evaluated by assigning a number for each that expressed its merit relative to the corresponding attribute of the Reference Process. Each alternative process was then ranked by summing the numbers for attributes in each of the four assessment areas and collectively. Fuel bundle disassembly and close packing of fuel pins was ranked the preferred method of disposal of spent fuel. 63 references, 46 figures, 46 tables

  10. Engineering multifunctional protein nanoparticles by in vitro disassembling and reassembling of heterologous building blocks

    Science.gov (United States)

    Unzueta, Ugutz; Serna, Naroa; Sánchez-García, Laura; Roldán, Mónica; Sánchez-Chardi, Alejandro; Mangues, Ramón; Villaverde, Antonio; Vázquez, Esther

    2017-12-01

    The engineering of protein self-assembling at the nanoscale allows the generation of functional and biocompatible materials, which can be produced by easy biological fabrication. The combination of cationic and histidine-rich stretches in fusion proteins promotes oligomerization as stable protein-only regular nanoparticles that are composed by a moderate number of building blocks. Among other applications, these materials are highly appealing as tools in targeted drug delivery once empowered with peptidic ligands of cell surface receptors. In this context, we have dissected here this simple technological platform regarding the controlled disassembling and reassembling of the composing building blocks. By applying high salt and imidazole in combination, nanoparticles are disassembled in a process that is fully reversible upon removal of the disrupting agents. By taking this approach, we accomplish here the in vitro generation of hybrid nanoparticles formed by heterologous building blocks. This fact demonstrates the capability to generate multifunctional and/or multiparatopic or multispecific materials usable in nanomedical applications.

  11. Allocation of reactive power support, active loss balancing and demand interruption ancillary services in MicroGrids

    Energy Technology Data Exchange (ETDEWEB)

    Gomes, Mario Helder [Departamento de Engenharia Electrotecnica, Instituto Politecnico de Tomar, Quinta do Contador, Estrada da Serra, 2300 Tomar (Portugal); Saraiva, Joao Tome [INESC Porto and Faculdade de Engenharia da Universidade do Porto, Campus da FEUP, Rua Dr. Roberto Frias, 4200 - 465 Porto (Portugal)

    2010-10-15

    MicroGrids represent a new paradigm for the operation of distribution systems and there are several advantages as well as challenges regarding their development. One of the advantages is related with the participation of MicroGrid agents in electricity markets and in the provision of ancillary services. This paper describes two optimization models to allocate three ancillary services among MicroGrid agents - reactive power/voltage control, active loss balancing and demand interruption. These models assume that MicroGrid agents participate in the day-ahead market sending their bids to the MicroGrid Central Controller, MGCC, that acts as an interface with the Market Operator. Once the Market Operator returns the economic dispatch of the MicroGrid agents, the MGCC checks its technical feasibility (namely voltage magnitude and branch flow limits) and activates an adjustment market to change the initial schedule and to allocate these three ancillary services. One of the models has crisp nature considering that voltage and branch flow limits are rigid while the second one admits that voltage and branch flow limits are modeled in a soft way using Fuzzy Set concepts. Finally, the paper illustrates the application of these models with a Case Study using a 55 node MV/LV network. (author)

  12. Balanced nuclear and cytoplasmic activities of EDS1 are required for a complete plant innate immune response.

    Directory of Open Access Journals (Sweden)

    Ana V García

    2010-07-01

    Full Text Available An important layer of plant innate immunity to host-adapted pathogens is conferred by intracellular nucleotide-binding/oligomerization domain-leucine rich repeat (NB-LRR receptors recognizing specific microbial effectors. Signaling from activated receptors of the TIR (Toll/Interleukin-1 Receptor-NB-LRR class converges on the nucleo-cytoplasmic immune regulator EDS1 (Enhanced Disease Susceptibility1. In this report we show that a receptor-stimulated increase in accumulation of nuclear EDS1 precedes or coincides with the EDS1-dependent induction and repression of defense-related genes. EDS1 is capable of nuclear transport receptor-mediated shuttling between the cytoplasm and nucleus. By enhancing EDS1 export from inside nuclei (through attachment of an additional nuclear export sequence (NES or conditionally releasing EDS1 to the nucleus (by fusion to a glucocorticoid receptor (GR in transgenic Arabidopsis we establish that the EDS1 nuclear pool is essential for resistance to biotrophic and hemi-biotrophic pathogens and for transcriptional reprogramming. Evidence points to post-transcriptional processes regulating receptor-triggered accumulation of EDS1 in nuclei. Changes in nuclear EDS1 levels become equilibrated with the cytoplasmic EDS1 pool and cytoplasmic EDS1 is needed for complete resistance and restriction of host cell death at infection sites. We propose that coordinated nuclear and cytoplasmic activities of EDS1 enable the plant to mount an appropriately balanced immune response to pathogen attack.

  13. A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior.

    Science.gov (United States)

    Kromann-Hansen, Tobias; Oldenburg, Emil; Yung, Kristen Wing Yu; Ghassabeh, Gholamreza H; Muyldermans, Serge; Declerck, Paul J; Huang, Mingdong; Andreasen, Peter A; Ngo, Jacky Chi Ki

    2016-07-15

    A peptide segment that binds the active site of a serine protease in a substrate-like manner may behave like an inhibitor or a substrate. However, there is sparse information on which factors determine the behavior a particular peptide segment will exhibit. Here, we describe the first x-ray crystal structure of a nanobody in complex with a serine protease. The nanobody displays a new type of interaction between an antibody and a serine protease as it inserts its complementary determining region-H3 loop into the active site of the protease in a substrate-like manner. The unique binding mechanism causes the nanobody to behave as a strong inhibitor as well as a poor substrate. Intriguingly, its substrate behavior is incomplete, as 30-40% of the nanobody remained intact and inhibitory after prolonged incubation with the protease. Biochemical analysis reveals that an intra-loop interaction network within the complementary determining region-H3 of the nanobody balances its inhibitor versus substrate behavior. Collectively, our results unveil molecular factors, which may be a general mechanism to determine the substrate versus inhibitor behavior of other protease inhibitors. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  14. A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior*

    Science.gov (United States)

    Kromann-Hansen, Tobias; Oldenburg, Emil; Yung, Kristen Wing Yu; Ghassabeh, Gholamreza H.; Muyldermans, Serge; Declerck, Paul J.; Huang, Mingdong; Andreasen, Peter A.; Ngo, Jacky Chi Ki

    2016-01-01

    A peptide segment that binds the active site of a serine protease in a substrate-like manner may behave like an inhibitor or a substrate. However, there is sparse information on which factors determine the behavior a particular peptide segment will exhibit. Here, we describe the first x-ray crystal structure of a nanobody in complex with a serine protease. The nanobody displays a new type of interaction between an antibody and a serine protease as it inserts its complementary determining region-H3 loop into the active site of the protease in a substrate-like manner. The unique binding mechanism causes the nanobody to behave as a strong inhibitor as well as a poor substrate. Intriguingly, its substrate behavior is incomplete, as 30–40% of the nanobody remained intact and inhibitory after prolonged incubation with the protease. Biochemical analysis reveals that an intra-loop interaction network within the complementary determining region-H3 of the nanobody balances its inhibitor versus substrate behavior. Collectively, our results unveil molecular factors, which may be a general mechanism to determine the substrate versus inhibitor behavior of other protease inhibitors. PMID:27226628

  15. Assisting People with Multiple Disabilities Actively Correct Abnormal Standing Posture with a Nintendo Wii Balance Board through Controlling Environmental Stimulation

    Science.gov (United States)

    Shih, Ching-Hsiang; Shih, Ching-Tien; Chu, Chiung-Ling

    2010-01-01

    The latest researches adopted software technology turning the Nintendo Wii Balance Board into a high performance change of standing posture (CSP) detector, and assessed whether two persons with multiple disabilities would be able to control environmental stimulation using body swing (changing standing posture). This study extends Wii Balance Board…

  16. Oleuropein potentiates anti-tumor activity of cisplatin against HepG2 through affecting proNGF/NGF balance.

    Science.gov (United States)

    Sherif, Iman O; Al-Gayyar, Mohammed M H

    2018-04-01

    Oleuropein is considered as a new chemotherapeutic agent in human hepatocellular carcinoma (HCC) while, its exact underlying molecular mechanism still not yet explored. In addition, cisplatin is a standard anticancer drug against solid tumors with toxic side effects. Therefore, we conducted this study to assess antitumor activity of oleuropein either alone or in combination with cisplatin against HepG2, human HCC cell lines, via targeting pro-NGF/NGF signaling pathway. HepG2 cells were treated with cisplatin (20, 50, 100 μM) and oleuropein (100, 200, 300 and 400 μM) as well as some of the cells were treated with 50 μM cisplatin and different concentrations of oleuropein. Gene expressions of nerve growth factor (NGF), matrix metalloproteinase-7 (MMP-7) and caspase-3 were evaluated by real time-PCR. In addition, protein levels of NGF and pro-form of NGF (pro-NGF) were measured by ELISA while, nitric oxide (NO) content was determined colorimetrically. Cisplatin treatment showed a significant elevation of NO content and pro-NGF protein level with a marked reduction of NGF protein level in addition to the upregulation of caspase-3 along with downregulation of MMP-7 gene expressions in a dose-dependent manner. However, the combination of 50 μM cisplatin and 200 μM oleuropein showed the most potent effect on the molecular level when compared with oleuropein or cisplatin alone. Our results showed for the first time that the anti-tumor activity of oleuropein against HCC could be attributed to influencing the pro-NGF/NGF balance via affecting MMP-7 activity without affecting the gene expression of NGF. Concurrent treatment with both oleuropein and cisplatin could lead to more effective chemotherapeutic combination against HCC. Copyright © 2018 Elsevier Inc. All rights reserved.

  17. Balancing Audio

    DEFF Research Database (Denmark)

    Walther-Hansen, Mads

    2016-01-01

    is not thoroughly understood. In this paper I treat balance as a metaphor that we use to reason about several different actions in music production, such as adjusting levels, editing the frequency spectrum or the spatiality of the recording. This study is based on an exploration of a linguistic corpus of sound......This paper explores the concept of balance in music production and examines the role of conceptual metaphors in reasoning about audio editing. Balance may be the most central concept in record production, however, the way we cognitively understand and respond meaningfully to a mix requiring balance...

  18. Balance Food and Activity

    Science.gov (United States)

    ... Lung, and Blood Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the National Cancer ...

  19. A Nuclear Role for miR-9 and Argonaute Proteins in Balancing Quiescent and Activated Neural Stem Cell States

    Directory of Open Access Journals (Sweden)

    Shauna Katz

    2016-10-01

    Full Text Available Throughout life, adult neural stem cells (NSCs produce new neurons and glia that contribute to crucial brain functions. Quiescence is an essential protective feature of adult NSCs; however, the establishment and maintenance of this state remain poorly understood. We demonstrate that in the adult zebrafish pallium, the brain-enriched miR-9 is expressed exclusively in a subset of quiescent NSCs, highlighting a heterogeneity within these cells, and is necessary to maintain NSC quiescence. Strikingly, miR-9, along with Argonaute proteins (Agos, is localized to the nucleus of quiescent NSCs, and manipulating their nuclear/cytoplasmic ratio impacts quiescence. Mechanistically, miR-9 permits efficient Notch signaling to promote quiescence, and we identify the RISC protein TNRC6 as a mediator of miR-9/Agos nuclear localization in vivo. We propose a conserved non-canonical role for nuclear miR-9/Agos in controlling the balance between NSC quiescence and activation, a key step in maintaining adult germinal pools.

  20. A Wireless Object Location Detector Enabling People with Developmental Disabilities to Control Environmental Stimulation through Simple Occupational Activities with Nintendo Wii Balance Boards

    Science.gov (United States)

    Shih, Ching-Hsiang; Chang, Man-Ling

    2012-01-01

    The latest researches have adopted software technology, turning the Nintendo Wii Balance Board into a high performance standing location detector with a newly developed standing location detection program (SLDP). This study extended SLDP functionality to assess whether two people with developmental disabilities would be able to actively perform…

  1. Polygons and adhesion plaques and the disassembly and assembly of myofibrils in cardiac myocytes.

    Science.gov (United States)

    Lin, Z X; Holtzer, S; Schultheiss, T; Murray, J; Masaki, T; Fischman, D A; Holtzer, H

    1989-06-01

    Successive stages in the disassembly of myofibrils and the subsequent assembly of new myofibrils have been studied in cultures of dissociated chick cardiac myocytes. The myofibrils in trypsinized and dispersed myocytes are sequentially disassembled during the first 3 d of culture. They split longitudinally and then assemble into transitory polygons. Multiples of single sarcomeres, the cardiac polygons, are analogous to the transitory polygonal configurations assumed by stress fibers in spreading fibroblasts. They differ from their counterparts in fibroblasts in that they consist of muscle alpha-actinin vertices and muscle myosin heavy chain struts, rather than of the nonmuscle contractile protein isoforms of stress fiber polygons. EM sections reveal the vertices and struts in cardiac polygons to be typical Z and A bands. Most cardiac polygons are eliminated by day 5 of culture. Concurrent with the disassembly and elimination of the original myofibrils new myofibrils are rapidly assembled elsewhere in the same myocyte. Without exception both distal tips of each nascent myofibril terminate in adhesion plaques. The morphology and composition of the adhesion plaques capping each end of each myofibril are similar to those of the termini of stress fibers in fibroblasts. However, whereas the adhesion complexes involving stress fibers in fibroblasts consist of vinculin/nonmuscle alpha-actinin/beta- and gamma-actins, the analogous structures in myocytes involving myofibrils consist of vinculin/muscle alpha-actinin/alpha-actin. The addition of 1.7-2.0 microns sarcomeres to the distal tips of an elongating myofibril, irrespective of whether the myofibril consists of 1, 10, or several hundred tandem sarcomeres, occurs while the myofibril appears to remain linked to its respective adhesion plaques. The adhesion plaques in vitro are the equivalent of the in vivo intercalated discs, both in terms of their molecular composition and with respect to their functioning as initiating

  2. Pelvic belt effects on pelvic morphometry, muscle activity and body balance in patients with sacroiliac joint dysfunction.

    Directory of Open Access Journals (Sweden)

    Odette Soisson

    Full Text Available The sacroiliac joint (SIJ is frequently involved in low back and pelvic girdle pain. However, morphometrical and functional characteristics related to SIJ pain are poorly defined. Pelvic belts represent one treatment option, but evidence still lacks as to their pain-reducing effects and the mechanisms involved. Addressing these two issues, this case-controlled study compares morphometric, functional and clinical data in SIJ patients and healthy controls and evaluates the effects of short-term pelvic belt application.Morphometric and functional data pertaining to pelvic belt effects were compared in 17 SIJ patients and 17 controls. Lumbar spine and pelvis morphometries were obtained from 3T magnetic resonance imaging. Functional electromyography data of pelvis and leg muscles and center of pressure excursions were measured in one-leg stance. The numerical rating scale was used to evaluate immediate pain-reducing effects.Pelvic morphometry was largely unaltered in SIJ patients and also by pelvic belt application. The angle of lumbar lateral flexion was significantly larger in SIJ patients without belt application. Muscle activity and center of pressure were unaffected by SIJ pain or by belt application in one-leg stance. Nine of 17 patients reported decreased pain intensities under moderate belt application, four reported no change and four reported increased pain intensity. For the entire population investigated here, this qualitative description was not confirmed on a statistical significant level.Minute changes were observed in the alignment of the lumbar spine in the frontal plane in SIJ patients. The potential pain-decreasing effects of pelvic belts could not be attributed to altered muscle activity, pelvic morphometry or body balance in a static short-term application. Long-term belt effects will therefore be of prospective interest.

  3. Pelvic Belt Effects on Pelvic Morphometry, Muscle Activity and Body Balance in Patients with Sacroiliac Joint Dysfunction

    Science.gov (United States)

    Soisson, Odette; Lube, Juliane; Germano, Andresa; Hammer, Karl-Heinz; Josten, Christoph; Sichting, Freddy; Winkler, Dirk; Milani, Thomas L.; Hammer, Niels

    2015-01-01

    Introduction The sacroiliac joint (SIJ) is frequently involved in low back and pelvic girdle pain. However, morphometrical and functional characteristics related to SIJ pain are poorly defined. Pelvic belts represent one treatment option, but evidence still lacks as to their pain-reducing effects and the mechanisms involved. Addressing these two issues, this case-controlled study compares morphometric, functional and clinical data in SIJ patients and healthy controls and evaluates the effects of short-term pelvic belt application. Methods Morphometric and functional data pertaining to pelvic belt effects were compared in 17 SIJ patients and 17 controls. Lumbar spine and pelvis morphometries were obtained from 3T magnetic resonance imaging. Functional electromyography data of pelvis and leg muscles and center of pressure excursions were measured in one-leg stance. The numerical rating scale was used to evaluate immediate pain-reducing effects. Results Pelvic morphometry was largely unaltered in SIJ patients and also by pelvic belt application. The angle of lumbar lateral flexion was significantly larger in SIJ patients without belt application. Muscle activity and center of pressure were unaffected by SIJ pain or by belt application in one-leg stance. Nine of 17 patients reported decreased pain intensities under moderate belt application, four reported no change and four reported increased pain intensity. For the entire population investigated here, this qualitative description was not confirmed on a statistical significant level. Discussion Minute changes were observed in the alignment of the lumbar spine in the frontal plane in SIJ patients. The potential pain-decreasing effects of pelvic belts could not be attributed to altered muscle activity, pelvic morphometry or body balance in a static short-term application. Long-term belt effects will therefore be of prospective interest. PMID:25781325

  4. Rasch Analysis of the Activities-specific Balance Confidence (ABC) Scale in Older Adults Seeking Outpatient Rehabilitation Services.

    Science.gov (United States)

    Wang, Ying-Chih; Sindhu, Bhagwant; Lehman, Leigh; Li, Xiaoyan; Yen, Sheng-Che; Kapellusch, Jay

    2018-03-30

    Study Design Cross-sectional study of 5,012 older patients seeking outpatient rehabilitation therapy in 123 clinics. Background The Activities-Specific Balance Confidence (ABC) Scale measures confidence in performing various ambulatory activities without falling or experiencing a sense of unsteadiness. Objectives Our purposes were to: (1) examine the ABC Scale (0-100) using the Rasch analysis, (2) assess statistically reliable change, and (3) develop a functional staging to guide clinical interpretation of the patient's improvement. Methods We examined rating scale structure, item difficulty hierarchy, item fit, person-item match, separation index, differential item functioning (DIF), test precision, and unidimensionality. Additionally, we estimated the minimal detectable change (MDC) and developed a functional staging. Results Item 'walking outside on icy sidewalks' was the most difficult item, while 'reach for a small can off a shelf at eye level' was the easiest item. Overall, average patient ability estimates of 56.2 (20.3) was slightly higher than the average item difficulty estimates of 45.9 (7.8). With a separation index equaled to 3.65, the ABC items can differentiate persons into 5.2 statistically distinct strata. Most ABC items were free of DIF. For example, 'walk outside on icy sidewalks' was easier for patients who was underweight. Results supported unidimensionality of the ABC Scale, with the first factor explained 77% of the total variance. The estimated MDC was 15 points. We provided an example of functional staging application. Conclusion Results supported sound psychometric properties and clinical usage of the ABC Scale for older adults seeking outpatient rehabilitation therapy. Level of Evidence 2c. J Orthop Sports Phys Ther, Epub 30 Mar 2018. doi:10.2519/jospt.2018.8023.

  5. Pelvic belt effects on pelvic morphometry, muscle activity and body balance in patients with sacroiliac joint dysfunction.

    Science.gov (United States)

    Soisson, Odette; Lube, Juliane; Germano, Andresa; Hammer, Karl-Heinz; Josten, Christoph; Sichting, Freddy; Winkler, Dirk; Milani, Thomas L; Hammer, Niels

    2015-01-01

    The sacroiliac joint (SIJ) is frequently involved in low back and pelvic girdle pain. However, morphometrical and functional characteristics related to SIJ pain are poorly defined. Pelvic belts represent one treatment option, but evidence still lacks as to their pain-reducing effects and the mechanisms involved. Addressing these two issues, this case-controlled study compares morphometric, functional and clinical data in SIJ patients and healthy controls and evaluates the effects of short-term pelvic belt application. Morphometric and functional data pertaining to pelvic belt effects were compared in 17 SIJ patients and 17 controls. Lumbar spine and pelvis morphometries were obtained from 3T magnetic resonance imaging. Functional electromyography data of pelvis and leg muscles and center of pressure excursions were measured in one-leg stance. The numerical rating scale was used to evaluate immediate pain-reducing effects. Pelvic morphometry was largely unaltered in SIJ patients and also by pelvic belt application. The angle of lumbar lateral flexion was significantly larger in SIJ patients without belt application. Muscle activity and center of pressure were unaffected by SIJ pain or by belt application in one-leg stance. Nine of 17 patients reported decreased pain intensities under moderate belt application, four reported no change and four reported increased pain intensity. For the entire population investigated here, this qualitative description was not confirmed on a statistical significant level. Minute changes were observed in the alignment of the lumbar spine in the frontal plane in SIJ patients. The potential pain-decreasing effects of pelvic belts could not be attributed to altered muscle activity, pelvic morphometry or body balance in a static short-term application. Long-term belt effects will therefore be of prospective interest.

  6. Balanced sampling

    NARCIS (Netherlands)

    Brus, D.J.

    2015-01-01

    In balanced sampling a linear relation between the soil property of interest and one or more covariates with known means is exploited in selecting the sampling locations. Recent developments make this sampling design attractive for statistical soil surveys. This paper introduces balanced sampling

  7. Adapting the Wii Fit Balance Board to Enable Active Video Game Play by Wheelchair Users: User-Centered Design and Usability Evaluation.

    Science.gov (United States)

    Thirumalai, Mohanraj; Kirkland, William B; Misko, Samuel R; Padalabalanarayanan, Sangeetha; Malone, Laurie A

    2018-03-06

    Active video game (AVG) playing, also known as "exergaming," is increasingly employed to promote physical activity across all age groups. The Wii Fit Balance Board is a popular gaming controller for AVGs and is used in a variety of settings. However, the commercial off-the-shelf (OTS) design poses several limitations. It is inaccessible to wheelchair users, does not support the use of stabilization assistive devices, and requires the ability to shift the center of balance (COB) in all directions to fully engage in game play. The aim of this study was to design an adapted version of the Wii Fit Balance Board to overcome the identified limitations and to evaluate the usability of the newly designed adapted Wii Fit Balance Board in persons with mobility impairments. In a previous study, 16 participants tried the OTS version of the Wii Fit Balance Board. On the basis of observed limitations, a team of engineers developed and adapted the design of the Wii Fit Balance Board, which was then subjected to multiple iterations of user feedback and design tweaks. On design completion, we recruited a new pool of participants with mobility impairments for a larger study. During their first visit, we assessed lower-extremity function using selected mobility tasks from the International Classification of Functioning, Disability and Health. During a subsequent session, participants played 2 sets of games on both the OTS and adapted versions of the Wii Fit Balance Board. Order of controller version played first was randomized. After participants played each version, we administered the System Usability Scale (SUS) to examine the participants' perceived usability. The adapted version of the Wii Fit Balance Board resulting from the user-centered design approach met the needs of a variety of users. The adapted controller (1) allowed manual wheelchair users to engage in game play, which was previously not possible; (2) included Americans with Disabilities Act-compliant handrails as part

  8. pH-Sensitive Reversible Programmed Targeting Strategy by the Self-Assembly/Disassembly of Gold Nanoparticles.

    Science.gov (United States)

    Ma, Jinlong; Hu, Zhenpeng; Wang, Wei; Wang, Xinyu; Wu, Qiang; Yuan, Zhi

    2017-05-24

    A reversible programmed targeting strategy could achieve high tumor accumulation due to its long blood circulation time and high cellular internalization. Here, targeting ligand-modified poly(ethylene glycol) (PEG-ligand), dibutylamines (Bu), and pyrrolidinamines (Py) were introduced on the surface of gold nanoparticles (Au NPs) for reversible shielding/deshielding of the targeting ligands by pH-responsive self-assembly. Hydrophobic interaction and steric repulsion are the main driving forces for the self-assembly/disassembly of Au NPs. The precise self-assembly (pH ≥ 7.2) and disassembly (pH ≤ 6.8) of Au NPs with different ligands could be achieved by fine-tuning the modifying molar ratio of Bu and Py (R m ), which followed the formula R m = 1/(-0.0013X 2 + 0.0323X + 1), in which X is the logarithm of the partition coefficient of the targeting ligand. The assembled/disassembled behavior of Au NPs at pH 7.2 and 6.8 was confirmed by transmission electron microscopy and dynamic light scattering. Enzyme-linked immunosorbent assays and cellular uptake studies showed that the ligands could be buried inside the assembly and exposed when disassembled. More importantly, this process was reversible, which provides the possibility of prolonging blood circulation by shielding ligands associated with the NPs that were effused from tumor tissue.

  9. Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication

    Directory of Open Access Journals (Sweden)

    Marija Maric

    2017-03-01

    Full Text Available Disassembly of the Cdc45-MCM-GINS (CMG DNA helicase is the key regulated step during DNA replication termination in eukaryotes, involving ubiquitylation of the Mcm7 helicase subunit, leading to a disassembly process that requires the Cdc48 “segregase”. Here, we employ a screen to identify partners of budding yeast Cdc48 that are important for disassembly of ubiquitylated CMG helicase at the end of chromosome replication. We demonstrate that the ubiquitin-binding Ufd1-Npl4 complex recruits Cdc48 to ubiquitylated CMG. Ubiquitylation of CMG in yeast cell extracts is dependent upon lysine 29 of Mcm7, which is the only detectable site of ubiquitylation both in vitro and in vivo (though in vivo other sites can be modified when K29 is mutated. Mutation of K29 abrogates in vitro recruitment of Ufd1-Npl4-Cdc48 to the CMG helicase, supporting a model whereby Ufd1-Npl4 recruits Cdc48 to ubiquitylated CMG at the end of chromosome replication, thereby driving the disassembly reaction.

  10. Neuroprotective Effects against POCD by Photobiomodulation: Evidence from Assembly/Disassembly of the Cytoskeleton

    Directory of Open Access Journals (Sweden)

    Ann D. Liebert

    2016-01-01

    Full Text Available Postoperative cognitive dysfunction (POCD is a decline in memory following anaesthesia and surgery in elderly patients. While often reversible, it consumes medical resources, compromises patient well-being, and possibly accelerates progression into Alzheimer's disease. Anesthetics have been implicated in POCD, as has neuroinflammation, as indicated by cytokine inflammatory markers. Photobiomodulation (PBM is an effective treatment for a number of conditions, including inflammation. PBM also has a direct effect on microtubule disassembly in neurons with the formation of small, reversible varicosities, which cause neural blockade and alleviation of pain symptoms. This mimics endogenously formed varicosities that are neuroprotective against damage, toxins, and the formation of larger, destructive varicosities and focal swellings. It is proposed that PBM may be effective as a preconditioning treatment against POCD; similar to the PBM treatment, protective and abscopal effects that have been demonstrated in experimental models of macular degeneration, neurological, and cardiac conditions.

  11. Chain Assembly and Disassembly Processes Differently Affect the Conformational Space of Ubiquitin Chains.

    Science.gov (United States)

    Kniss, Andreas; Schuetz, Denise; Kazemi, Sina; Pluska, Lukas; Spindler, Philipp E; Rogov, Vladimir V; Husnjak, Koraljka; Dikic, Ivan; Güntert, Peter; Sommer, Thomas; Prisner, Thomas F; Dötsch, Volker

    2018-02-06

    Ubiquitination is the most versatile posttranslational modification. The information is encoded by linkage type as well as chain length, which are translated by ubiquitin binding domains into specific signaling events. Chain topology determines the conformational space of a ubiquitin chain and adds an additional regulatory layer to this ubiquitin code. In particular, processes that modify chain length will be affected by chain conformations as they require access to the elongation or cleavage sites. We investigated conformational distributions in the context of chain elongation and disassembly using pulsed electron-electron double resonance spectroscopy in combination with molecular modeling. Analysis of the conformational space of diubiquitin revealed conformational selection or remodeling as mechanisms for chain recognition during elongation or hydrolysis, respectively. Chain elongation to tetraubiquitin increases the sampled conformational space, suggesting that a high intrinsic flexibility of K48-linked chains may contribute to efficient proteasomal degradation. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Disassembly Control of Saccharide-Based Amphiphiles Driven by Electrostatic Repulsion.

    Science.gov (United States)

    Yamada, Taihei; Kokado, Kenta; Sada, Kazuki

    2017-03-14

    According to the design of disassembly using electrostatic repulsion, novel amphiphiles consisting of a lipophilic ion part and a hydrophilic saccharide part were synthesized via the facile copper-catalyzed click reaction, and their molecular assemblies in water and chloroform were studied. The amphiphiles exhibited a molecular orientation opposite to that of the conventional amphiphiles in each case. ζ Potential measurements indicated that the lipophilic ion part is exposed outside in chloroform. The size of a solvophobic part in the amphiphiles dominates the size of an assembling structure; that is, in water, these amphiphiles tethering different lengths of the saccharide part exhibited almost identical assembling size, whereas in chloroform, the size depends on the length of the saccharide part in the amphiphiles.

  13. TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly

    Science.gov (United States)

    Uchil, Pradeep D.; Pawliczek, Tobias; Reynolds, Tracy D.; Ding, Siyuan; Hinz, Angelika; Munro, James B.; Huang, Fang; Floyd, Robert W.; Yang, Haitao; Hamilton, William L.; Bewersdorf, Joerg; Xiong, Yong; Calderwood, David A.; Mothes, Walther

    2014-01-01

    ABSTRACT Focal adhesions are macromolecular complexes that connect the actin cytoskeleton to the extracellular matrix. Dynamic turnover of focal adhesions is crucial for cell migration. Paxillin is a multi-adaptor protein that plays an important role in regulating focal adhesion dynamics. Here, we identify TRIM15, a member of the tripartite motif protein family, as a paxillin-interacting factor and a component of focal adhesions. TRIM15 localizes to focal contacts in a myosin-II-independent manner by an interaction between its coiled-coil domain and the LD2 motif of paxillin. Unlike other focal adhesion proteins, TRIM15 is a stable focal adhesion component with restricted mobility due to its ability to form oligomers. TRIM15-depleted cells display impaired cell migration and reduced focal adhesion disassembly rates, in addition to enlarged focal adhesions. Thus, our studies demonstrate a cellular function for TRIM15 as a regulatory component of focal adhesion turnover and cell migration. PMID:25015296

  14. Electrostatic assembly/disassembly of nanoscaled colloidosomes for light-triggered cargo release

    KAUST Repository

    Li, Song

    2015-04-27

    Colloidosome capsules possess the potential for the encapsulation and release of molecular and macromolecular cargos. However, the stabilization of the colloidosome shell usually requires an additional covalent crosslinking which irreversibly seals the capsules, and greatly limits their applications in large-cargos release. Herein we report nanoscaled colloidosomes designed by the electrostatic assembly of organosilica nanoparticles (NPs) with oppositely charged surfaces (rather than covalent bonds), arising from different contents of a bridged nitrophenylene-alkoxysilane [NB; 3-nitro-N-(3-(triethoxysilyl)propyl)-4-(((3-(triethoxysilyl)propyl)-amino)methyl)benzamid] derivative in the silica. The surface charge of the positively charged NPs was reversed by light irradiation because of a photoreaction in the NB moieties, which impacted the electrostatic interactions between NPs and disassembled the colloidosome nanosystems. This design was successfully applied for the encapsulation and light-triggered release of cargos. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Acoustically Triggered Disassembly of Multilayered Polyelectrolyte Thin Films through Gigahertz Resonators for Controlled Drug Release Applications

    Directory of Open Access Journals (Sweden)

    Zhixin Zhang

    2016-11-01

    Full Text Available Controlled drug release has a high priority for the development of modern medicine and biochemistry. To develop a versatile method for controlled release, a miniaturized acoustic gigahertz (GHz resonator is designed and fabricated which can transfer electric supply to mechanical vibrations. By contacting with liquid, the GHz resonator directly excites streaming flows and induces physical shear stress to tear the multilayered polyelectrolyte (PET thin films. Due to the ultra-high working frequency, the shear stress is greatly intensified, which results in a controlled disassembling of the PET thin films. This technique is demonstrated as an effective method to trigger and control the drug release. Both theory analysis and controlled release experiments prove the thin film destruction and the drug release.

  16. Reliability and validity of the German short version of the Activities specific Balance Confidence (ABC-D6) scale in older adults.

    Science.gov (United States)

    Schott, Nadja

    2014-01-01

    The Activities specific Balance Confidence (ABC) is a questionnaire which was developed to assess falls-associated self-efficacy. The aim of this study was to evaluate reliability and validity of the German abbreviated 6-item version of the ABC scores in community-dwelling older people. The study sample included 384 subjects (age 71.1 ± 9.7). In order to determine the psychometric properties, reliability and validity were assessed through administration of the German adaptation of the ABC-D16 to participants twice, 10 days apart, and comparison of the ABC-D16 and the ABC-D6 with functional measures of balance and mobility (one-leg stance; 10 m walk; TUG; Fullerton Advanced Balance Scale (FAB)), physical activity (Physical Activity Scale for the Elderly (PASE)), physical fitness (30s arm curl, 30s chair stand, 6 min walk), cognition (Trail-Making-Test (TMT)), falls status, and quality of life (SF36). Factor analyses suggested a 1-factor solution for the ABC-D6 scale (explained variance 79.8%). Internal consistency (.95) and test-retest reliability (.98) for the ABC-D6 scores were excellent. Scores on the ABC-D6 were significantly lower than on the ABC-D16, but ABC-D16 and ABC-D6 scores were highly correlated (.94). There was an increasing difference in the ABC-scores between men and women with increasing age. Fallers reported lower balance confidence than non-fallers. The ABC-D6 score significantly correlated with functional measures of balance and mobility, physical activity, physical fitness, cognition, and quality of life (-.698valid instrument to asses falls-associated self-efficacy and may be used in future research projects and clinical trials. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  17. Impact of physical activity on energy balance, food intake and choice in normal weight and obese children in the setting of acute social stress: a randomized controlled trial.

    Science.gov (United States)

    Horsch, Antje; Wobmann, Marion; Kriemler, Susi; Munsch, Simone; Borloz, Sylvie; Balz, Alexandra; Marques-Vidal, Pedro; Borghini, Ayala; Puder, Jardena J

    2015-02-19

    Psychological stress negatively influences food intake and food choices, thereby contributing to the development of childhood obesity. Physical activity can also moderate eating behavior and influence calorie intake. However, it is unknown if acute physical activity influences food intake and overall energy balance after acute stress exposure in children. We therefore investigated the impact of acute physical activity on overall energy balance (food intake minus energy expenditure), food intake, and choice in the setting of acute social stress in normal weight (NW) and overweight/obese (OW/OB) children as well as the impact of psychological risk factors. After receiving written consent from their parents, 26 NW (BMI foods (6 sweet/6 salty; each of low/high caloric density). Energy balance, food intake/choice and obesity-related psychological risk factors were assessed. Lower overall energy balance (p = 0.019) and a decreased choice of low density salty foods (p foods (104 kcal (34 to 173), p = 0.004) following stress. They scored higher on impulsive behavior (p = 0.005), restrained eating (p stress-induced food intake/choice. Positive parenting tended to be related to lower intake of sweet high density food (-132 kcal, -277 to 2, p = 0.054). In the setting of stress, acute moderate physical activity can address energy balance in children, a benefit which is especially pronounced in the OW/OB. Positive parenting may act as a protective factor preventing stress-induced eating of comfort food. clinicaltrials.gov NCT01693926 The study was a pilot study of a project funded by the Swiss National Science Foundation (CRSII3_147673).

  18. Balancing mechanism status: November 2009

    International Nuclear Information System (INIS)

    2009-01-01

    RTE ensures the real-time balance between production and consumption and deals with congestion on the French electricity system. The Balancing Mechanism assists in the accomplishment of this task. As in many countries, and after extensive dialogue with representatives from the market's various players, RTE proposes a Balancing Mechanism in the form of a permanent and transparent system of calls for tender. The system is open to everyone and provides a real-time reserve of power that can be used for balancing either upward or downward. RTE takes advantage of these offers according to economic precedence, taking into account the system's operating conditions. It pays for them at the offer price. There are two types of offer: - Upward offer: increase in production, decrease in consumption, imports, - Downward offer: decrease in production, increase in consumption, exports. For a Balancing Entity, an offer systematically consists of: a balancing direction (upward/downward), a time period, a price that may vary according to six time slots. RTE publishes each month a Balancing Mechanism Report. which includes the following information: - energy volumes activated to ensure the balance of the system and to resolve congestion; - minimum and maximum prices of offers activated to balance the system; - daily trends calculated according to the predominant value of the overall upward or downward trend; - balancing shares by technology (nuclear, thermal, hydraulic); - characteristics of the five most activated balancing entities; - balances/imbalances accounts and production/consumption overcharge; - congestion curbing costs on the French electricity system; - energy volumes activated to ensure the balance of the system according to contracts between RTE and other Balance Responsible entities (UK, Belgium, Italy, Germany, Switzerland); - reliability of the provisional data supplied by RTE about the balancing trend; - availability of RTE's information services (planning, balancing

  19. Balancing mechanism status: May 2009

    International Nuclear Information System (INIS)

    2009-01-01

    RTE ensures the real-time balance between production and consumption and deals with congestion on the French electricity system. The Balancing Mechanism assists in the accomplishment of this task. As in many countries, and after extensive dialogue with representatives from the market's various players, RTE proposes a Balancing Mechanism in the form of a permanent and transparent system of calls for tender. The system is open to everyone and provides a real-time reserve of power that can be used for balancing either upward or downward. RTE takes advantage of these offers according to economic precedence, taking into account the system's operating conditions. It pays for them at the offer price. There are two types of offer: - Upward offer: increase in production, decrease in consumption, imports, - Downward offer: decrease in production, increase in consumption, exports. For a Balancing Entity, an offer systematically consists of: a balancing direction (upward/downward), a time period, a price that may vary according to six time slots. RTE publishes each month a Balancing Mechanism Report. which includes the following information: - energy volumes activated to ensure the balance of the system and to resolve congestion; - minimum and maximum prices of offers activated to balance the system; - daily trends calculated according to the predominant value of the overall upward or downward trend; - balancing shares by technology (nuclear, thermal, hydraulic); - characteristics of the five most activated balancing entities; - balances/imbalances accounts and production/consumption overcharge; - congestion curbing costs on the French electricity system; - energy volumes activated to ensure the balance of the system according to contracts between RTE and other Balance Responsible entities (UK, Belgium, Italy, Germany, Switzerland); - reliability of the provisional data supplied by RTE about the balancing trend; - availability of RTE's information services (planning, balancing

  20. Thermoregulation of water foraging honeybees--balancing of endothermic activity with radiative heat gain and functional requirements.

    Science.gov (United States)

    Kovac, Helmut; Stabentheiner, Anton; Schmaranzer, Sigurd

    2010-12-01

    Foraging honeybees are subjected to considerable variations of microclimatic conditions challenging their thermoregulatory ability. Solar heat is a gain in the cold but may be a burden in the heat. We investigated the balancing of endothermic activity with radiative heat gain and physiological functions of water foraging Apis mellifera carnica honeybees in the whole range of ambient temperatures (T(a)) and solar radiation they are likely to be exposed in their natural environment in Middle Europe. The mean thorax temperature (T(th)) during foraging stays was regulated at a constantly high level (37.0-38.5 °C) in a broad range of T(a) (3-30 °C). At warmer conditions (T(a)=30-39 °C) T(th) increased to a maximal level of 45.3 °C. The endothermic temperature excess (difference of T(body)-T(a) of living and dead bees) was used to assess the endogenously generated temperature elevation as a correlate of energy turnover. Up to a T(a) of ∼30 °C bees used solar heat gain for a double purpose: to reduce energetic expenditure and to increase T(th) by about 1-3 °C to improve force production of flight muscles. At higher T(a) they exhibited cooling efforts to get rid of excess heat. A high T(th) also allowed regulation of the head temperature high enough to guarantee proper function of the bees' suction pump even at low T(a). This shortened the foraging stays and this way reduced energetic costs. With decreasing T(a) bees also reduced arrival body weight and crop loading to do both minimize costs and optimize flight performance. Copyright © 2010 Elsevier Ltd. All rights reserved.

  1. The Diet Quality of Competitive Adolescent Male Rugby Union Players with Energy Balance Estimated Using Different Physical Activity Coefficients

    Directory of Open Access Journals (Sweden)

    Tracy Burrows

    2016-09-01

    Full Text Available Objectives: The aims of the current study were to comprehensively assess the dietary intakes and diet quality of a sample of Australian competitive adolescent rugby union players and compare these intakes with National and Sports Dietitians Association (SDA Recommendations for adolescent athletes. A secondary aim investigated applying different physical activity level (PAL coefficients to determine total energy expenditure (TEE in order to more effectively evaluate the adequacy of energy intakes. Design: Cross-sectional. Methods: Anthropometrics and dietary intakes were assessed in 25 competitive adolescent male rugby union players (14 to 18 years old. Diet was assessed using the validated Australian Eating Survey (AES food frequency questionnaire and diet quality was assessed through the Australian Recommended Food Score. Results: The median dietary intakes of participants met national recommendations for percent energy (% E from carbohydrate, protein and total fat, but not carbohydrate intake when evaluated as g/day as proposed in SDA guidelines. Median intakes of fibre and micronutrients including calcium and iron also met national recommendations. Overall diet quality was classified as ‘good’ with a median diet quality score of 34 (out of a possible 73; however, there was a lack of variety within key food groups including carbohydrates and proteins. Non-core food consumption exceeded recommended levels at 38% of the daily total energy intake, with substantial contributions from takeaway foods and sweetened beverages. A PAL coefficient of 1.2–1.4 was found to best balance the energy intakes of these players in their pre-season. Conclusions: Adolescent rugby players met the percent energy recommendations for macronutrients and attained an overall ‘good’ diet quality score. However, it was identified that when compared to specific recommendations for athletes, carbohydrate intakes were below recommendations and these players in their

  2. Wii Fit® training vs. Adapted Physical Activities: which one is the most appropriate to improve the balance of independent senior subjects? A randomized controlled study.

    Science.gov (United States)

    Toulotte, Claire; Toursel, Cindy; Olivier, Nicolas

    2012-09-01

    To compare the effectiveness of three protocols (Adapted Physical Activities, Wii Fit(®), Adapted Physical Activities + Wii Fit(®)) on the balance of independent senior subjects. Case comparison study. Healthy elderly subjects living in independent community dwellings. Thirty-six subjects, average age 75.09 ± 10.26 years, took part in this study, and were randomly assigned to one of the four experimental groups: G1 followed an Adapted Physical Activities training programme, while the second group (G2) participated in Wii Fit(®) training and the third one (G3) combined both methods. There was no training for the fourth group (G4). All subjects trained once a week (1 hour) for 20 weeks and were assessed before and after treatment. The Tinetti test, unipedal tests and the Wii Fit(®) tests. After training, the scores in the Tinetti test decreased significantly (P Wii Fit(®)) and G3 (Adapted Physical Activities and Wii Fit(®)) improved their balance. In addition, G1 and G3 increased their dynamic balance. The findings suggest that Adapted Physical Activities training limits the decline in sensorial functions in the elderly.

  3. The effect of different skin-ankle brace application pressures on quiet single-limb balance and electromyographic activation onset of lower limb muscles

    Directory of Open Access Journals (Sweden)

    Papadakis Stamatios A

    2007-09-01

    Full Text Available Abstract Background Several studies have been carried out in order to investigate the effect of ankle bracing on ankle joint function and performance. However, no study so far has examined the role of skin-brace interface pressure in neuromuscular control. The aim of this study was to investigate the effect of different skin-ankle brace interface pressures on quiet single limb balance and the electromyographic (EMG activation sequence of four lower limb muscles. Methods Thirty three male physical education students who volunteered to take part in the study were measured under three ankle brace conditions: i without brace, ii with brace and 30 kPa application pressure and iii with brace and 60 kPa application pressure. Single limb balance (anteroposterior and mediolateral parameter was assessed on the dominant lower limb, with open and closed eyes, on a force platform, simultaneously with the EMG recording of four lower lower limb muscles' (gastrocnemius, peroneus longus, rectus femoris and biceps femoris activation onset. Results The results showed that overall balance (total stability parameter was not significantly affected in any of the three ankle brace conditions. However, the anteroposterior centre of pressure excursion and centre of pressure excursion velocity were significantly increased with the application of ankle brace, both with 30 and 60 kPa application pressures. Furthermore, it was found that single limb balance was significantly worse with closed eyes compared to open eyes. EMG measurements showed that the sequence of lower limb activation onset was not affected in any of the three ankle brace application conditions. The results of this study showed that the application of an ankle brace with two different skin-brace interface pressures had no effect on overall single limb balance and the sequence of lower limb muscle activation. Conclusion These findings suggest that peripheral joint receptors are either not adequately

  4. Energy balance measurement

    DEFF Research Database (Denmark)

    Dhurandhar, N V; Schoeller, D; Brown, A W

    2015-01-01

    Energy intake (EI) and physical activity energy expenditure (PAEE) are key modifiable determinants of energy balance, traditionally assessed by self-report despite its repeated demonstration of considerable inaccuracies. We argue here that it is time to move from the common view that self......-reports of EI and PAEE are imperfect, but nevertheless deserving of use, to a view commensurate with the evidence that self-reports of EI and PAEE are so poor that they are wholly unacceptable for scientific research on EI and PAEE. While new strategies for objectively determining energy balance...... of energy balance....

  5. The The Effects of Cold Water Immersion on Anaerobic Power, Dynamic Balance and Muscle Activation After a karate kumite fighting in Female Karateka

    Directory of Open Access Journals (Sweden)

    Taher Afshar Nezhad

    2017-10-01

    Full Text Available Many athletes are using specific techniques to minimize fatigue and accelerate recovery processes. Cold water immersion (CWI is one of the most popular interventions used by athletes to potentially return to their pre-fatigue performance level. the purpose of this study was to investigate the effects of CWI on anaerobic performance, balance and muscle activation of female karateka after a simulated match. 15 young female karateka (age: 18.7±1.7 years, body mass: 55.5±6.3 kg, height:165±5.1 cm with at least three years' experience in karate kumite fighting were included in the study. After three round 3-minute competition, participants were grouped into a CWI group (20 min at 12±1°C and a control group (CTL. Anaerobic power (30 s Wingate test, and dynamic balance (Star-Excursion test were measured before the competition and 24 h after intervention. Surface electromyography (EMG was sampled from quadriceps femoris muscles. Peak normalized muscle activation levels and force were identified during maximal isometric test. A significant decrease in the anaerobic performance after the competition was observed for both groups (p<0.05. CWI were effective in enhancing the anaerobic performance after competition compared with the CTL. Dynamic balance decreased for two groups, although CWI resulted in the smallest reduction in balance. There was a significant difference in peak and mean RMS values of the EMG in Rectus Femoris but not Vastus muscles after the CWI intervention when compared to CTL (p<0.05. CWI improve recovery related to dynamic balance and anaerobic performance of karate kumite fighter. It can be concluded that CWI appears to promote muscle activation and reduce fatigue that is related to better performance in 24 hours post intervention.

  6. Final Status Survey Report for Corrective Action Unit 117 - Pluto Disassembly Facility, Building 2201, Nevada National Security Site, Nevada

    International Nuclear Information System (INIS)

    Gwin, Jeremy; Frenette, Douglas

    2010-01-01

    This document contains the process knowledge, radiological data and subsequent statistical methodology and analysis to support approval for the radiological release of Corrective Action Unit (CAU) 117 - Pluto Disassembly Facility, Building 2201 located in Area 26 of the Nevada National Security Site (NNSS). Preparations for release of the building began in 2009 and followed the methodology described in the Multi-Agency Radiation Survey and Site Investigation Manual (MARSSIM). MARSSIM is the DOE approved process for release of Real Property (buildings and landmasses) to a set of established criteria or authorized limits. The pre-approved authorized limits for surface contamination values and corresponding assumptions were established by DOE O 5400.5. The release criteria coincide with the acceptance criteria of the U10C landfill permit. The U10C landfill is the proposed location to dispose of the radiologically non-impacted, or ''clean,'' building rubble following demolition. However, other disposition options that include the building and/or waste remaining at the NNSS may be considered providing that the same release limits apply. The Final Status Survey was designed following MARSSIM guidance by reviewing historical documentation and radiological survey data. Following this review a formal radiological characterization survey was performed in two phases. The characterization revealed multiple areas of residual radioactivity above the release criteria. These locations were remediated (decontaminated) and then the surface activity was verified to be less than the release criteria. Once remediation efforts had been successfully completed, a Final Status Survey Plan (10-015, ''Final Status Survey Plan for Corrective Action Unit 117 - Pluto Disassembly Facility, Building 2201'') was developed and implemented to complete the final step in the MARSSIM process, the Final Status Survey. The Final Status Survey Plan consisted of categorizing each individual room into one

  7. Adapted physical activity is beneficial on balance, functional mobility, quality of life and fall risk in community-dwelling older women: a randomized single-blinded controlled trial.

    Science.gov (United States)

    Kovács, E; Prókai, L; Mészáros, L; Gondos, T

    2013-06-01

    Exercise programmes have important role in prevention of falls, but to date, we have little knowledge about the effects of Adapted Physical Activity programme on balance of older women. The aim of this study was to investigate the effects of an Adapted Physical Activity programme on balance, risk of falls and quality of life in community-dwelling older women. This was a randomized controlled study. Community, in a local sport centre. Older women aged over 60 years. Seventy-six women were randomised to an exercise group providing Adapted Physical Activity programme for 25 weeks or a control group (in which they did not participate in any exercise programme). The one-leg stance test, Timed Up and Go test, incidence of fall and the quality of life (SF-36V2) were measured at baseline and after 25 weeks. The one-leg stance test and the Timed Up and Go test in the exercise group was significantly better than in the control group after the intervention period (P=0.005; P=0.001, respectively). The Physical Functioning, Vitality and General Health subdomains of quality of life were also significantly better in the exercise group compared to the control group (P=0.004; P=0.005; P=0.038, respectively). Relative risk was 0.40 (90% CI 0.174 to 0.920) and the number needed to treat was 5 (95% CI 2.3 to 23.3). This 25-week Adapted Physical Activity programme improves static balance, functional mobility, as well as Physical Functioning, Vitality and General Health subdomains of quality of life. Based on our results, the Adapted Physical Activity programme may be a promising fall prevention exercise programme improving static balance and functional mobility for community-dwelling older women.

  8. Effects of Nintendo Wii™ Training on Occupational Performance, Balance, and Daily Living Activities in Children with Spastic Hemiplegic Cerebral Palsy: A Single-Blind and Randomized Trial.

    Science.gov (United States)

    Atasavun Uysal, Songül; Baltaci, Gül

    2016-10-05

    This study aimed at assessing how the addition of Nintendo Wii ™ (NW) system to the traditional therapy influences occupational performance, balance, and daily living activities in children with spastic hemiplegic Cerebral Palsy (CP). The present study is a single-blind and randomized trial involving 24 children aged 6-14 years, classified as level I or II on the Gross Motor Function Classification System. The children were allocated into two groups: an intervention and a control group, and their families participated in the study. The activity performance analysis of the children was undertaken by using the Canadian Occupational Performance Measure (COPM), functional balance was measured with the Pediatric Balance Scale (PBS), and activities of daily living were assessed with Pediatric Evaluation of Disability Inventory (PEDI). Twenty-four children with CP were randomly divided into two groups: intervention (n = 12) and control group (n = 12). All children in both groups continued their traditional physiotherapy program twice a week, 45 minutes per session, whereas the participants in the intervention group, additionally, were trained with NW, two other days of the week for 12 weeks, with each session lasting for 30 minutes. Self-care, mobility, PEDI total, PBS, and performance of COPM scores increased in the NW group after intervention. Self-care, mobility, and total PEDI increased in the control group as well. However, there was no statistically significant difference found between the groups, except for PBS (P < 0.05). NW contributed to the implementation of occupational performance, daily living activities, and functional balance. We recommend that NW could be used in the rehabilitation program to engage play-based activities with fun.

  9. The influence of broiler activity, growth rate, and litter on carbon dioxide balances for the determination of ventilation flow rates in broiler production.

    Science.gov (United States)

    Calvet, S; Estellés, F; Cambra-López, M; Torres, A G; Van den Weghe, H F A

    2011-11-01

    Carbon dioxide balances are useful in determining ventilation rates in livestock buildings. These balances need an accurate estimation of the CO(2) produced by animals and their litter to determine the ventilation flows. To estimate the daily variation in ventilation flow, it is necessary to precisely know the daily variation pattern of CO(2) production, which mainly depends on animal activity. The objective of this study was to explore the applicability of CO(2) balances for determining ventilation flows in broiler buildings. More specifically, this work aimed to quantify the amount of CO(2) produced by the litter, as well as the amount of CO(2) produced by the broilers, as a function of productive parameters, and to analyze the influence of broiler activity on CO(2) emissions. Gas concentrations and ventilation flows were simultaneously measured in 3 trials, with 1 under experimental conditions and the other 2 in a commercial broiler farm. In the experimental assay, broiler activity was also determined. At the end of the experimental trial, on the day after the removal of the broilers, the litter accounted for 20% of the total CO(2) produced, and the broilers produced 3.71 L/h of CO(2) per kg of metabolic weight. On the commercial farm, CO(2) production was the same for the 2 cycles (2.60 L/h per kg of metabolic weight, P > 0.05). However, substantial differences were found between CO(2) and broiler activity patterns after changes in light status. A regression model was used to explain these differences (R(2) = 0.52). Carbon dioxide increased with bird activity, being on average 3.02 L/h per kg of metabolic weight for inactive birds and 4.73 L/h per kg of metabolic weight when bird activity was highest. Overall, CO(2) balances are robust tools for determining the daily average ventilation flows in broiler farms. These balances could also be applied at more frequent intervals, but in this case, particular care is necessary after light status changes because of

  10. An anterior cruciate ligament injury does not affect the neuromuscular function of the non-injured leg except for dynamic balance and voluntary quadriceps activation.

    Science.gov (United States)

    Zult, Tjerk; Gokeler, Alli; van Raay, Jos J A M; Brouwer, Reinoud W; Zijdewind, Inge; Hortobágyi, Tibor

    2017-01-01

    The function of the anterior cruciate ligament (ACL) patients' non-injured leg is relevant in light of the high incidence of secondary ACL injuries on the contralateral side. However, the non-injured leg's function has only been examined for a selected number of neuromuscular outcomes and often without appropriate control groups. We measured a broad array of neuromuscular functions between legs of ACL patients and compared outcomes to age, sex, and physical activity matched controls. Thirty-two ACL-deficient patients (208 ± 145 days post-injury) and active and less-active controls (N = 20 each) participated in the study. We measured single- and multi-joint neuromuscular function in both legs in each group and expressed the overall neuromuscular function in each leg by calculating a mean z-score across all neuromuscular measures. A group by leg MANOVA and ANOVA were performed to examine group and leg differences for the selected outcomes. After an ACL injury, duration (-4.3 h/week) and level (Tegner activity score of -3.9) of sports activity decreased and was comparable to less-active controls. ACL patients showed bilateral impairments in the star excursion balance test compared to both control groups (P ≤ 0.004) and for central activation ratio compared to active controls (P ≤ 0.002). There were between-leg differences within each group for maximal quadriceps and hamstring strength, voluntary quadriceps activation, star excursion balance test performance, and single-leg hop distance (all P joint proprioception, and static balance. Overall neuromuscular function (mean z-score) did not differ between groups, but ACL patients' non-injured leg displayed better neuromuscular function than the injured leg (P neuromuscular deficits despite reductions in physical activity after injury. Therapists can use the non-injured leg as a reference to assess the injured leg's function for tasks measured in the present study, excluding dynamic balance and quadriceps

  11. Effects of hunger level and nutrient balance on survival and acetylcholinesterase activity of dimethoate exposed wolf spiders

    DEFF Research Database (Denmark)

    Pedersen, Lars-Flemming; Dall, Lars G.; Sorensen, Bo C.

    2002-01-01

    The influence of two nutritional factors (food quantity and quality) on the responses of a wolf spider, Pardosa prativaga (L.K.), to a high dose of the insecticide dimethoate, was investigated in a fully factorial experimental design. Spider groups with different (good and bad) nutrient balance w...

  12. Dynamic Energy Balance: An Integrated Framework for Discussing Diet and Physical Activity in Obesity Prevention-Is it More than Eating Less and Exercising More?

    Science.gov (United States)

    Manore, Melinda M; Larson-Meyer, D Enette; Lindsay, Anne R; Hongu, Nobuko; Houtkooper, Linda

    2017-08-19

    Understanding the dynamic nature of energy balance, and the interrelated and synergistic roles of diet and physical activity (PA) on body weight, will enable nutrition educators to be more effective in implementing obesity prevention education. Although most educators recognize that diet and PA are important for weight management, they may not fully understand their impact on energy flux and how diet alters energy expenditure and energy expenditure alters diet. Many nutrition educators have little training in exercise science; thus, they may not have the knowledge essential to understanding the benefits of PA for health or weight management beyond burning calories. This paper highlights the importance of advancing nutrition educators' understanding about PA, and its synergistic role with diet, and the value of incorporating a dynamic energy balance approach into obesity-prevention programs. Five key points are highlighted: (1) the concept of dynamic vs. static energy balance; (2) the role of PA in weight management; (3) the role of PA in appetite regulation; (4) the concept of energy flux; and (5) the integration of dynamic energy balance into obesity prevention programs. The rationale for the importance of understanding the physiological relationship between PA and diet for effective obesity prevention programming is also reviewed.

  13. VENUS-2, Reactor Kinetics with Feedback, 2-D LMFBR Disassembly Excursions

    International Nuclear Information System (INIS)

    Jackson, J.F.; Nicholson, R.B.; Weber, D.P.

    1980-01-01

    1 - Description of problem or function: VENUS-2 is an improved edition of the VENUS fast-reactor disassembly program. It is a two- dimensional (r-z) coupled neutronics-hydrodynamics code that calculates the dynamic behavior of an LMFBR during a prompt-critical disassembly excursion. It calculates the power history and fission energy release as well as the space-time histories of the fuel temperatures, core material pressures, and core material motions. Reactivity feedback effects due to Doppler broadening and reactor material motion are taken into account. 2 - Method of solution: The power and energy release are calculated using a point-kinetics formulation with up to six delayed neutron groups. The reactivity is a combination of an input driving function and feedback effects due to Doppler broadening and material motion. An adiabatic model is used to calculate the temperature increase throughout the reactor based on an initial temperature distribution and power profile provided as input data. These temperatures are, in turn, converted to fuel pressures through one of several equation of state options provided. The material motion that results from the pressure buildup is calculated by a direct finite difference solution of a set of two-dimensional (r-z) hydrodynamics equations. This is done in Lagrangian coordinates. The reactivity change associated with this motion is calculated by first-order perturbation theory. The displacements are also used to adjust the fuel densities as required for the density dependent equation-of- state option. An automatic time-step-size selection scheme is provided. 3 - Restrictions on the complexity of the problem: VENUS-2 is written so that the dimensions of the storage arrays can be readily changed to accommodate a broad range of problem sizes. In the base version, the total number of mesh intervals is restricted such that (NR+3)*(NZ+3) is less than 700, where NR and NZ are the total number of mesh intervals in the r and z

  14. Assembly/disassembly of a complex icosahedral virus to incorporate heterologous nucleic acids

    Science.gov (United States)

    Pascual, Elena; Mata, Carlos P.; Carrascosa, José L.; Castón, José R.

    2017-12-01

    Hollow protein containers are widespread in nature, and include virus capsids as well as eukaryotic and bacterial complexes. Protein cages are studied extensively for applications in nanotechnology, nanomedicine and materials science. Their inner and outer surfaces can be modified chemically or genetically, and the internal cavity can be used to template, store and/or arrange molecular cargos. Virus capsids and virus-like particles (VLP, noninfectious particles) provide versatile platforms for nanoscale bioengineering. Study of capsid protein self-assembly into monodispersed particles, and of VLP structure and biophysics is necessary not only to understand natural processes, but also to infer how these platforms can be redesigned to furnish novel functional VLP. Here we address the assembly dynamics of infectious bursal disease virus (IBDV), a complex icosahedral virus. IBDV has a ~70 nm-diameter T  =  13 capsid with VP2 trimers as the only structural subunits. During capsid assembly, VP2 is synthesized as a precursor (pVP2) whose C terminus is cleaved. The pVP2 C terminus has an amphipathic helix that controls VP2 polymorphism. In the absence of the VP3 scaffolding protein, necessary for control of assembly, 466/456-residue pVP2 intermediates bearing this helix assemble into VLP only when expressed with an N-terminal His6 tag (the HT-VP2-466 protein). HT-VP2-466 capsids are optimal for genetic insertion of proteins (cargo space ~78 000 nm3). We established an in vitro assembly/disassembly system of HT-VP2-466-based VLP for heterologous nucleic acid packaging and/or encapsulation of drugs and other molecules. HT-VP2-466 (empty) capsids were disassembled and reassembled by dialysis against low-salt/basic pH and high-salt/acid pH buffers, respectively, thus illustrating the reversibility in vitro of IBDV capsid assembly. HT-VP2-466 VLP also packed heterologous DNA by non-specific confinement during assembly. These and previous results establish the bases

  15. Effects of a predefined mini-trampoline training programme on balance, mobility and activities of daily living after stroke: a randomized controlled pilot study.

    Science.gov (United States)

    Miklitsch, Claudia; Krewer, Carmen; Freivogel, Susanna; Steube, Diethard

    2013-10-01

    To investigate the effects of a predefined mini-trampoline therapy programme for increasing postural control, mobility and the ability to perform activities of daily living after stroke. Randomized non-blinded controlled pilot study. Neurological rehabilitation hospital. First-time stroke; age 18-80 years; independent standing ability for a minimum of 2 minutes. Patients were randomized into two groups: the mini-trampoline group (n = 20) received 10 sessions of balance training using the mini-trampoline over three weeks. The patients of the control group (n =20) participated 10 times in a group balance training also over three weeks. Postural control (Berg Balance Scale, BBS), mobility and gait endurance (timed 'up and go' test, TUG; 6-minute walk test, 6MWT) and the ability to perform activities of daily living (Barthel Index, BI). Measurements were undertaken prior to and after the intervention period. Both groups were comparable before the study. The mini-trampoline group improved significantly more in the BBS (P = 0.003) compared to the control group. Mean or median differences of both groups showed improvements in the TUG 10.12 seconds/7.23 seconds, the 6MWT 135 m/75 m and the BI 20 points/13 points for the mini-trampoline and control group, respectively. These outcome measurements did not differ significantly between the two groups. A predefined mini-trampoline training programme resulted in significantly increased postural control in stroke patients compared to balance training in a group. Although not statistically significant, the mini-trampoline training group showed increased improvement in mobility and activities of daily living. These differences could have been statistically significant if we had investigated more patients (i.e. a total sample of 84 patients for the TUG, 98 patients for the 6MWT, and 186 patients for the BI).

  16. Characterization of the disassembly and reassembly of the HBV glycoprotein surface antigen, a pliable nanoparticle vaccine platform

    International Nuclear Information System (INIS)

    Gallagher, John R.; Torian, Udana; McCraw, Dustin M.; Harris, Audray K.

    2017-01-01

    While nanoparticle vaccine technology is gaining interest due to the success of vaccines like those for the human papillomavirus that is based on viral capsid nanoparticles, little information is available on the disassembly and reassembly of viral surface glycoprotein-based nanoparticles. One such particle is the hepatitis B virus surface antigen (sAg) that exists as nanoparticles. Here we show, using biochemical analysis coupled with electron microscopy, that sAg nanoparticle disassembly requires both reducing agent to disrupt intermolecular disulfide bonds, and detergent to disrupt hydrophobic interactions that stabilize the nanoparticle. Particles were otherwise resistant to salt and urea, suggesting the driving mechanism of particle formation involves hydrophobic interactions. We reassembled isolated sAg protein into nanoparticles by detergent removal and reassembly resulted in a wider distribution of particle diameters. Knowledge of these driving forces of nanoparticle assembly and stability should facilitate construction of epitope-displaying nanoparticles that can be used as immunogens in vaccines.

  17. Characterization of the disassembly and reassembly of the HBV glycoprotein surface antigen, a pliable nanoparticle vaccine platform

    Energy Technology Data Exchange (ETDEWEB)

    Gallagher, John R.; Torian, Udana; McCraw, Dustin M.; Harris, Audray K., E-mail: harrisau@mail.nih.gov

    2017-02-15

    While nanoparticle vaccine technology is gaining interest due to the success of vaccines like those for the human papillomavirus that is based on viral capsid nanoparticles, little information is available on the disassembly and reassembly of viral surface glycoprotein-based nanoparticles. One such particle is the hepatitis B virus surface antigen (sAg) that exists as nanoparticles. Here we show, using biochemical analysis coupled with electron microscopy, that sAg nanoparticle disassembly requires both reducing agent to disrupt intermolecular disulfide bonds, and detergent to disrupt hydrophobic interactions that stabilize the nanoparticle. Particles were otherwise resistant to salt and urea, suggesting the driving mechanism of particle formation involves hydrophobic interactions. We reassembled isolated sAg protein into nanoparticles by detergent removal and reassembly resulted in a wider distribution of particle diameters. Knowledge of these driving forces of nanoparticle assembly and stability should facilitate construction of epitope-displaying nanoparticles that can be used as immunogens in vaccines.

  18. Balance Disorders

    Science.gov (United States)

    ... vertigo. If you have additional problems with motor control, such as weakness, slowness, tremor, or rigidity, you can lose your ability to recover properly from imbalance. This raises the risk of falling and injury. What are some types of balance disorders? There are more than a dozen different ...

  19. Balancing Eggs

    Science.gov (United States)

    Mills, Allan

    2014-01-01

    Theory predicts that an egg-shaped body should rest in stable equilibrium when on its side, balance vertically in metastable equilibrium on its broad end and be completely unstable on its narrow end. A homogeneous solid egg made from wood, clay or plastic behaves in this way, but a real egg will not stand on either end. It is shown that this…

  20. Effectiveness of Balancing Everyday Life (BEL) versus standard occupational therapy for activity engagement and functioning among people with mental illness - a cluster RCT study.

    Science.gov (United States)

    Eklund, Mona; Tjörnstrand, Carina; Sandlund, Mikael; Argentzell, Elisabeth

    2017-11-09

    Many with a mental illness have an impoverished everyday life with few meaningful activities and a sedentary lifestyle. The study aim was to evaluate the effectiveness of the 16-week Balancing Everyday Life (BEL) program, compared to care as usual (CAU), for people with mental illness in specialized and community-based psychiatric services. The main outcomes concerned different aspects of subjectively evaluated everyday activities, in terms of the engagement and satisfaction they bring, balance among activities, and activity level. Secondary outcomes pertained to various facets of well-being and functioning. It was hypothesized that those who received the BEL intervention would improve more than the comparison group regarding activity, well-being and functioning outcomes. BEL is a group and activity-based lifestyle intervention. CAU entailed active support, mainly standard occupational therapy. The BEL group included 133 participants and the CAU group 93. They completed self-report questionnaires targeting activity and well-being on three occasions - at baseline, after completed intervention (at 16 weeks) and at a six-month follow-up. A research assistant rated the participants' level of functioning and symptom severity on the same occasions. Non-parametric statistics were used since these instruments produced ordinal data. The BEL group improved more than the CAU group from baseline to 16 weeks on primary outcomes in terms of activity engagement (p life) more than the CAU group from baseline to the follow-up (p = 0.049). No differences were found at that time for activity balance, level of functioning and symptom severity. The BEL program was effective compared to CAU in terms of activity engagement. Their improvements were not, however, greater concerning other subjective perceptions, such as satisfaction with daily activities and self-rated health, and clustering effects lowered the dependability regarding findings of improvements on symptoms and

  1. Disassembly of Bacterial Biofilms by the Self-Assembled Glycolipids Derived from Renewable Resources.

    Science.gov (United States)

    Prasad, Yadavali Siva; Miryala, Sandeep; Lalitha, Krishnamoorthy; Ranjitha, K; Barbhaiwala, Shehnaz; Sridharan, Vellaisamy; Maheswari, C Uma; Srinandan, C S; Nagarajan, Subbiah

    2017-11-22

    More than 80% of chronic infections of bacteria are caused by biofilms. It is also a long-term survival strategy of the pathogens in a nonhost environment. Several amphiphilic molecules have been used in the past to potentially disrupt biofilms; however, the involvement of multistep synthesis, complicated purification and poor yield still remains a major problem. Herein, we report a facile synthesis of glycolipid based surfactant from renewable feedstocks in good yield. The nature of carbohydrate unit present in glycolipid influence the ring chain tautomerism, which resulted in the existence of either cyclic structure or both cyclic and acyclic structures. Interestingly, these glycolipids self-assemble into gel in highly hydrophobic solvents and vegetable oils, and displayed foam formation in water. The potential application of these self-assembled glycolipids to disrupt preformed biofilm was examined against various pathogens. It was observed that glycolipid 6a disrupts Staphylococcus aureus and Listeria monocytogenes biofilm, while the compound 6c was effective in disassembling uropathogenic E. coli and Salmonella enterica Typhimurium biofilms. Altogether, the supramolecular self-assembled materials, either as gel or as surfactant solution could be potentially used for surface cleansing in hospital environments or the food processing industries to effectively reduce pathogenic biofilms.

  2. Disassembly of actin structures by nanosecond pulsed electric field is a downstream effect of cell swelling.

    Science.gov (United States)

    Pakhomov, Andrei G; Xiao, Shu; Pakhomova, Olga N; Semenov, Iurii; Kuipers, Marjorie A; Ibey, Bennett L

    2014-12-01

    Disruption of the actin cytoskeleton structures was reported as one of the characteristic effects of nanosecond-duration pulsed electric field (nsPEF) in both mammalian and plant cells. We utilized CHO cells that expressed the monomeric fluorescent protein (mApple) tagged to actin to test if nsPEF modifies the cell actin directly or as a consequence of cell membrane permeabilization. A train of four 600-ns pulses at 19.2 kV/cm (2 Hz) caused immediate cell membrane poration manifested by YO-PRO-1 dye uptake, gradual cell rounding and swelling. Concurrently, bright actin features were replaced by dimmer and uniform fluorescence of diffuse actin. To block the nsPEF-induced swelling, the bath buffer was isoosmotically supplemented with an electropore-impermeable solute (sucrose). A similar addition of a smaller, electropore-permeable solute (adonitol) served as a control. We demonstrated that sucrose efficiently blocked disassembly of actin features by nsPEF, whereas adonitol did not. Sucrose also attenuated bleaching of mApple-tagged actin in nsPEF-treated cells (as integrated over the cell volume), although did not fully prevent it. We conclude that disintegration of the actin cytoskeleton was a result of cell swelling, which, in turn, was caused by cell permeabilization by nsPEF and transmembrane diffusion of solutes which led to the osmotic imbalance. Copyright © 2014 Elsevier B.V. All rights reserved.

  3. Role of a reducing environment in disassembly of the herpesvirus tegument

    Energy Technology Data Exchange (ETDEWEB)

    Newcomb, William W. [Department of Microbiology Immunology and Cancer Biology, University of Virginia Health System, Box 800734, University of Virginia Health System, 1300 Jefferson Park Ave. Charlottesville, VA 22908 (United States); Jones, Lisa M. [Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130 (United States); Dee, Alexander [Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, Farmington, CT 06030 (United States); Chaudhry, Farid [Department of Microbiology Immunology and Cancer Biology, University of Virginia Health System, Box 800734, University of Virginia Health System, 1300 Jefferson Park Ave. Charlottesville, VA 22908 (United States); Brown, Jay C., E-mail: JCB2G@VIRGINIA.EDU [Department of Microbiology Immunology and Cancer Biology, University of Virginia Health System, Box 800734, University of Virginia Health System, 1300 Jefferson Park Ave. Charlottesville, VA 22908 (United States)

    2012-09-15

    Initiation of infection by herpes family viruses involves a step in which most of the virus tegument becomes detached from the capsid. Detachment takes place in the host cell cytosol near the virus entry site and it is followed by dispersal of tegument proteins and disappearance of the tegument as a distinct entity. Here we describe the results of experiments designed to test the idea that the reducing environment of the cytosol may contribute to tegument detachment and disassembly. Non-ionic detergent was used to remove the membrane of purified herpes simplex virus under control and reducing conditions. The effects on the tegument were then examined by SDS-PAGE and electron microscopy. Protein analysis demonstrated that most major tegument proteins were removed under both oxidizing and reducing conditions except for UL49 which required a reducing environment. It is proposed therefore that the reducing conditions in the cytosol are involved in removal of UL49 protein. Electron microscopic analysis revealed that capsids produced under oxidizing conditions contained a coating of protein that was absent in reduced virions and which correlated uniquely with the presence of UL49. This capsid-associated layer is suggested to be the location of UL49 in the extracted virion.

  4. Effects of a High-Intensity Functional Exercise Program on Dependence in Activities of Daily Living and Balance in Older Adults with Dementia.

    Science.gov (United States)

    Toots, Annika; Littbrand, Håkan; Lindelöf, Nina; Wiklund, Robert; Holmberg, Henrik; Nordström, Peter; Lundin-Olsson, Lillemor; Gustafson, Yngve; Rosendahl, Erik

    2016-01-01

    To investigate the effects of a high-intensity functional exercise program on independence in activities of daily living (ADLs) and balance in older people with dementia and whether exercise effects differed between dementia types. Cluster-randomized controlled trial: Umeå Dementia and Exercise (UMDEX) study. Residential care facilities, Umeå, Sweden. Individuals aged 65 and older with a dementia diagnosis, a Mini-Mental State Examination score of 10 or greater, and dependence in ADLs (N=186). Ninety-three participants each were allocated to the high-intensity functional exercise program, comprising lower limb strength and balance exercises, and 93 to a seated control activity. Blinded assessors measured ADL independence using the Functional Independence Measure (FIM) and Barthel Index (BI) and balance using the Berg Balance Scale (BBS) at baseline and 4 (directly after intervention completion) and 7 months. Linear mixed models showed no between-group effect on ADL independence at 4 (FIM=1.3, 95% confidence interval (CI)=-1.6-4.3; BI=0.6, 95% CI=-0.2-1.4) or 7 (FIM=0.8, 95% CI=-2.2-3.8; BI=0.6, 95% CI=-0.3-1.4) months. A significant between-group effect on balance favoring exercise was observed at 4 months (BBS=4.2, 95% CI=1.8-6.6). In interaction analyses, exercise effects differed significantly between dementia types. Positive between-group exercise effects were found in participants with non-Alzheimer's dementia according to the FIM at 7 months and BI and BBS at 4 and 7 months. In older people with mild to moderate dementia living in residential care facilities, a 4-month high-intensity functional exercise program appears to slow decline in ADL independence and improve balance, albeit only in participants with non-Alzheimer's dementia. © 2016 The Authors. The Journal of the American Geriatrics Society published by Wiley Periodicals, Inc. on behalf of The American Geriatrics Society.

  5. The Effect of Uncertain End-of-Life Product Quality and Consumer Incentives on Partial Disassembly Sequencing in Value Recovery Operations

    OpenAIRE

    Rickli, Jeremy Lewis

    2013-01-01

    This dissertation addresses gaps in the interaction between End-of-Life (EoL) product acquisition systems and disassembly sequencing. The research focuses on two remanufacturing research problems; 1) modeling uncertain EoL product quality, quantity, and timing in regards to EoL product acquisition and disassembly sequencing and 2) designing EoL product acquisition schemes considering EoL product uncertainty. The main research objectives within these areas are; analyzing, predicting, and contr...

  6. Exercise training and return to a well-balanced diet activate the neuregulin 1/ErbB pathway in skeletal muscle of obese rats

    Science.gov (United States)

    Ennequin, Gaël; Boisseau, Nathalie; Caillaud, Kevin; Chavanelle, Vivien; Gerbaix, Maude; Metz, Lore; Etienne, Monique; Walrand, Stéphane; Masgrau, Aurélie; Guillet, Christelle; Courteix, Daniel; Niu, Airu; Li, Yi-Ping; Capel, Fréderic; Sirvent, Pascal

    2015-01-01

    Some studies suggest that the signalling pathway of neuregulin 1 (NRG1), a protein involved in the regulation of skeletal muscle metabolism, could be altered by nutritional and exercise interventions. We hypothesized that diet-induced obesity could lead to alterations of the NRG1 signalling pathway and that chronic exercise could improve NRG1 signalling in rat skeletal muscle. To test this hypothesis, male Wistar rats received a high fat/high sucrose (HF/HS) diet for 16 weeks. At the end of this period, NRG1 and ErbB expression/activity in skeletal muscle was assessed. The obese rats then continued the HF/HS diet or were switched to a well-balanced diet. Moreover, in both groups, half of the animals also performed low intensity treadmill exercise training. After another 8 weeks, NRG1 and ErbB expression/activity in skeletal muscle were tested again. The 16 week HF/HS diet induced obesity, but did not significantly affect the NRG1/ErbB signalling pathway in rat skeletal muscle. Conversely, after the switch to a well-balanced diet, NRG1 cleavage ratio and ErbB4 amount were increased. Chronic exercise training also promoted NRG1 cleavage, resulting in increased ErbB4 phosphorylation. This result was associated with increased protein expression and phosphorylation ratio of the metalloprotease ADAM17, which is involved in NRG1 shedding. Similarly, in vitro stretch-induced activation of ADAM17 in rat myoblasts induced NRG1 cleavage and ErbB4 activation. These results show that low intensity endurance training and well-balanced diet activate the NRG1-ErbB4 pathway, possibly via the metalloprotease ADAM17, in skeletal muscle of diet-induced obese rats. PMID:25820551

  7. Prosecutor's Office Role In The Process Of Ensuring Balance Between Private And Public Interests In The Conditions Of The Economic Activity Freedom

    Directory of Open Access Journals (Sweden)

    Nadezhda D. But

    2014-09-01

    Full Text Available Present article is devoted to the problem of prosecutor participation in the process of ensuring the balance of private and public interests during the supervision over laws on free economic activity execution. Authors noted the existence of need for the formation of the registers of subjects of small and medium business which aren't created so far. According to the authors, for more effective control over the balance of private and public interests the anti-corruption legislation of the Russian Federation, including the Federal Law of July 26, 2006 No. 135-FZ "On the competition protection" should be brought into accord with the international precepts of law and standards. Authors pay special attention to the questions of supervision, including reasons for the fact that during the supervision over the performance of laws in the conditions of the economic activity freedom in sight of prosecutors should be not dispositive, but imperative (regulatory and guarding legal norms. In the sphere of the prosecutor's law-enforcement activity in the conditions of economic activity freedom it is expedient to allocate such activity of prosecutors into the independent supervising subsector as it covers not only economic, but also other spheres of public life (state construction, social questions and many other. In the course of research authors analyze various regulations, opinions of scientists and practice of law application. In the conclusion authors explains opinion that questions listed in the present article need more accurate legislative regulation and realization in the law-enforcement practice.

  8. Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4–signalosome complex to regulate DNA repair and cell death

    Science.gov (United States)

    Rao, Feng; Xu, Jing; Khan, A. Basit; Gadalla, Moataz M.; Cha, Jiyoung Y.; Xu, Risheng; Tyagi, Richa; Dang, Yongjun; Chakraborty, Anutosh; Snyder, Solomon H.

    2014-01-01

    Inositol polyphosphates containing an energetic pyrophosphate bond are formed primarily by a family of three inositol hexakisphosphate (IP6) kinases (IP6K1–3). The Cullin-RING ubiquitin ligases (CRLs) regulate diverse biological processes through substrate ubiquitylation. CRL4, comprising the scaffold Cullin 4A/B, the E2-interacting Roc1/2, and the adaptor protein damage-specific DNA-binding protein 1, is activated by DNA damage. Basal CRL4 activity is inhibited by binding to the COP9 signalosome (CSN). UV radiation and other stressors dissociate the complex, leading to E3 ligase activation, but signaling events that trigger signalosome dissociation from CRL4 have been unclear. In the present study, we show that, under basal conditions, IP6K1 forms a ternary complex with CSN and CRL4 in which IP6K1 and CRL4 are inactive. UV dissociates IP6K1 to generate IP7, which then dissociates CSN–CRL4 to activate CRL4. Thus, IP6K1 is a novel CRL4 subunit that transduces UV signals to mediate disassembly of the CRL4–CSN complex, thereby regulating nucleotide excision repair and cell death. PMID:25349427

  9. Exercise training and return to a well-balanced diet activate the neuregulin 1/ErbB pathway in skeletal muscle of obese rats.

    Science.gov (United States)

    Ennequin, Gaël; Boisseau, Nathalie; Caillaud, Kevin; Chavanelle, Vivien; Gerbaix, Maude; Metz, Lore; Etienne, Monique; Walrand, Stéphane; Masgrau, Aurélie; Guillet, Christelle; Courteix, Daniel; Niu, Airu; Li, Yi-Ping; Capel, Fréderic; Sirvent, Pascal

    2015-06-15

    Some studies suggest that neuregulin 1 (NRG1) could be involved in the regulation of skeletal muscle energy metabolism in rodents. Here we assessed whether unbalanced diet is associated with alterations of the NRG1 signalling pathway and whether exercise and diet might restore NRG1 signalling in skeletal muscle of obese rats. We show that diet-induced obesity does not impair NRG1 signalling in rat skeletal muscle. We also report that endurance training and a well-balanced diet activate the NRG1 signalling in skeletal muscle of obese rats, possibly via a new mechanism mediated by the protease ADAM17. These results suggest that some beneficial effects of physical activity and diet in obese rats could be partly explained by stimulation of the NRG1 signalling pathway. Some studies suggest that the signalling pathway of neuregulin 1 (NRG1), a protein involved in the regulation of skeletal muscle metabolism, could be altered by nutritional and exercise interventions. We hypothesized that diet-induced obesity could lead to alterations of the NRG1 signalling pathway and that chronic exercise could improve NRG1 signalling in rat skeletal muscle. To test this hypothesis, male Wistar rats received a high fat/high sucrose (HF/HS) diet for 16 weeks. At the end of this period, NRG1 and ErbB expression/activity in skeletal muscle was assessed. The obese rats then continued the HF/HS diet or were switched to a well-balanced diet. Moreover, in both groups, half of the animals also performed low intensity treadmill exercise training. After another 8 weeks, NRG1 and ErbB expression/activity in skeletal muscle were tested again. The 16 week HF/HS diet induced obesity, but did not significantly affect the NRG1/ErbB signalling pathway in rat skeletal muscle. Conversely, after the switch to a well-balanced diet, NRG1 cleavage ratio and ErbB4 amount were increased. Chronic exercise training also promoted NRG1 cleavage, resulting in increased ErbB4 phosphorylation. This result was

  10. Balance ability and athletic performance.

    Science.gov (United States)

    Hrysomallis, Con

    2011-03-01

    The relationship between balance ability and sport injury risk has been established in many cases, but the relationship between balance ability and athletic performance is less clear. This review compares the balance ability of athletes from different sports, determines if there is a difference in balance ability of athletes at different levels of competition within the same sport, determines the relationship of balance ability with performance measures and examines the influence of balance training on sport performance or motor skills. Based on the available data from cross-sectional studies, gymnasts tended to have the best balance ability, followed by soccer players, swimmers, active control subjects and then basketball players. Surprisingly, no studies were found that compared the balance ability of rifle shooters with other athletes. There were some sports, such as rifle shooting, soccer and golf, where elite athletes were found to have superior balance ability compared with their less proficient counterparts, but this was not found to be the case for alpine skiing, surfing and judo. Balance ability was shown to be significantly related to rifle shooting accuracy, archery shooting accuracy, ice hockey maximum skating speed and simulated luge start speed, but not for baseball pitching accuracy or snowboarding ranking points. Prospective studies have shown that the addition of a balance training component to the activities of recreationally active subjects or physical education students has resulted in improvements in vertical jump, agility, shuttle run and downhill slalom skiing. A proposed mechanism for the enhancement in motor skills from balance training is an increase in the rate of force development. There are limited data on the influence of balance training on motor skills of elite athletes. When the effectiveness of balance training was compared with resistance training, it was found that resistance training produced superior performance results for

  11. Associations between active video gaming and other energy-balance related behaviours in adolescents : a 24-hour recall diary study

    NARCIS (Netherlands)

    Simons, Monique; Chinapaw, Mai J M; Brug, Johannes; Seidell, Jaap; de Vet, Emely

    2015-01-01

    BACKGROUND: Active video games may contribute to reducing time spent in sedentary activities, increasing physical activity and preventing excessive weight gain in adolescents. Active video gaming can, however, only be beneficial for weight management when it replaces sedentary activities and not

  12. Associations between active video gaming and other energy-balance related behaviours in adolescents: a 24-hour recall diary study

    NARCIS (Netherlands)

    Simons, M.; Chinapaw, M.J.M.; Brug, J.; Seidell, J.; Vet, E. de

    2015-01-01

    Background Active video games may contribute to reducing time spent in sedentary activities, increasing physical activity and preventing excessive weight gain in adolescents. Active video gaming can, however, only be beneficial for weight management when it replaces sedentary activities and not

  13. Associations between active video gaming and other energy-balance related behaviours in adolescents: a 24-hour recall diary study

    NARCIS (Netherlands)

    Simons, M.; Chinapaw, M.J.M.; Brug, J.; Seidell, J.C.; Vet, de E.

    2015-01-01

    Active video games may contribute to reducing time spent in sedentary activities, increasing physical activity and preventing excessive weight gain in adolescents. Active video gaming can, however, only be beneficial for weight management when it replaces sedentary activities and not other physical

  14. Pathway and Cell-Specific Kappa-Opioid Receptor Modulation of Excitatory-Inhibitory Balance Differentially Gates D1 and D2 Accumbens Neuron Activity

    Science.gov (United States)

    Tejeda, Hugo A.; Wu, Jocelyn; Kornspun, Alana R.; Pignatelli, Marco; Kashtelyan, Vadim; Krashes, Michael J.; Lowell, Brad B.; Carlezon, William A.; Bonci, Antonello

    2018-01-01

    Endogenous dynorphin signaling via the kappa-opioid receptor (KOR) in the nucleus accumbens (NAcc) powerfully mediates negative affective states and stress reactivity. Excitatory inputs from the hippocampus and amygdala play a fundamental role in shaping the activity of both NAcc D1 and D2 MSNs, which encode positive and negative motivational valences, respectively. However, a circuit-based mechanism by which KOR modulation of excitation-inhibition balance modifies D1 and D2 MSN activity is lacking. Here, we provide a comprehensive synaptic framework wherein presynaptic KOR inhibition decreases excitatory drive of D1 MSN activity by the amygdala, but not hippocampus. Conversely, presynaptic inhibition by KORs of inhibitory synapses on D2 MSNs enhances integration of excitatory drive by the amygdala and hippocampus. In conclusion, we describe a circuit-based mechanism showing differential gating of afferent control of D1 and D2 MSN activity by KORs in a pathway specific manner. PMID:28056342

  15. Correlation of physical aptitude; functional capacity, corporal balance and quality of life (QoL) among elderly women submitted to a post-menopausal physical activities program.

    Science.gov (United States)

    de Souza Santos, César Augusto; Dantas, Estélio Enrique Martin; Moreira, Maria Helena Rodrigues

    2011-01-01

    The objective of this study was to evaluate the effect of physical activity from the "Menopause in Form" program on physical aptitude, functional capacity, corporal balance and QoL among elderly women. In addition, correlations among these variables were examined. The present work was a longitudinal study that was quasi-experimental and correlational. A total of 323 elderly women (age: 69.0±5.53 years) participated in this study. Subjects were non-institutionalized, post-menopausal individuals residing at the Elderly Care Center in Belém Municipality (Pará, Brazil) and practiced one activity (i.e., dancing or walking) over a 10-month period. The assessment protocols used were the following: the Fullerton functional fitness test battery (physical aptitude); the activities of daily living (ADL) indices (functional capacity); the Tinetti-scale (corporal balance); and the WHOQOL-OLD questionnaire (QoL). The adopted significance level was p<0.05. Results from the Wilcoxon test demonstrated significant differences for the post-test assessment of functional capacity (Δ%=5.63%; p=0.0001) and general QoL (Δ%=9.19%; p=0.001). These results suggest that the physical activities employed during the "Menopause in Form" program resulted in significant improvements in the functional capacity and QoL of post-menopausal elderly women. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  16. Balanced activation of IspG and IspH to eliminate MEP intermediate accumulation and improve isoprenoids production in Escherichia coli.

    Science.gov (United States)

    Li, Qingyan; Fan, Feiyu; Gao, Xiang; Yang, Chen; Bi, Changhao; Tang, Jinlei; Liu, Tao; Zhang, Xueli

    2017-11-01

    The MEP pathway genes were modulated to investigate whether there were new rate-limiting steps and toxic intermediates in this pathway. Activating IspG led to significant decrease of cell growth and β-carotene production. It was found that ispG overexpression led to accumulation of intermediate HMBPP, which seriously interfered with synthesis machinery of nucleotide and protein in Escherichia coli. Activation of the downstream enzyme IspH could solve HMBPP accumulation problem and eliminate the negative effects of ispG overexpression. In addition, intermediate MECPP accumulated in the starting strain, while balanced activation of IspG and IspH could push the carbon flux away from MECPP and led to 73% and 77% increase of β-carotene and lycopene titer respectively. Our work for the first time identified HMBPP to be a cytotoxic intermediate in MEP pathway and demonstrated that balanced activation of IspG and IspH could eliminate accumulation of HMBPP and MECPP and improve isoprenoids production. Copyright © 2017 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.

  17. Determination of C0-60 in Cobalt Slugs and Slabs and Radionuclides in Curium Sampler Slugs L-Reactor Disassembly Basin

    International Nuclear Information System (INIS)

    Casella, V.R.

    2004-01-01

    Co-60 was historically produced in the SRS reactors. Cobalt slugs were irradiated in the early 1970s. Post-production, remaining cobalt slugs (including slab form) were consolidated for storage. There are approximately nine hundred cobalt slugs currently stored awaiting final disposition. These slugs had historically incomplete documentation for activity rates; therefore, assaying was required in order to determine their activity levels. Since the gamma dose rate from these slugs is extremely high, the most cost effective way to shield a source of this magnitude from personnel and the radiation detector was to use the basin water in which the slugs are stored as the shield. A sodium iodide gamma detector was placed above a specially designed air collimator assembly, so that slug was at least eight feet from the detector and was shielded by the basin water. Using a sodium iodide detector and multichannel analyzer system and an underwater collimator assembly, Co-60 concentrations we re determined for Disassembly Basin cobalt slugs and slabs and 18 curium sampler slugs. The total activity of all of the assayed slugs summed to 31,783 curies. From the Co-60 concentrations of the curium sampler slugs, the irradiation flux was determined for the known irradiation time. The amounts of Pu-238, 239, 240, 241, 242; Am-241, 243; and Cm-242, 244 produced were then obtained based on the original amount of Pu-239 irradiated

  18. Bidirectional and Multi-User Telerehabilitation System: Clinical Effect on Balance, Functional Activity, and Satisfaction in Patients with Chronic Stroke Living in Long-Term Care Facilities

    Directory of Open Access Journals (Sweden)

    Kwan-Hwa Lin

    2014-07-01

    Full Text Available Background: The application of internet technology for telerehabilitation in patients with stroke has developed rapidly. Objective: The current study aimed to evaluate the effect of a bidirectional and multi-user telerehabilitation system on balance and satisfaction in patients with chronic stroke living in long-term care facilities (LTCFs. Method: This pilot study used a multi-site, blocked randomization design. Twenty-four participants from three LTCFs were recruited, and the participants were randomly assigned into the telerehabilitation (Tele and conventional therapy (Conv groups within each LTCF. Tele group received telerehabilitation but the Conv group received conventional therapy with two persons in each group for three sessions per week and for four weeks. The outcome measures included Berg Balance Scale (BBS, Barthel Index (BI, and the telerehabilitation satisfaction of the participants. Setting: A telerehabilitation system included “therapist end” in a laboratory, and the “client end” in LTCFs. The conventional therapy was conducted in LTCFs. Results: Training programs conducted for both the Tele and Conv groups showed significant effects within groups on the participant BBS as well as the total and self-care scores of BI. No significant difference between groups could be demonstrated. The satisfaction of participants between the Tele and the Conv groups also did not show significant difference. Conclusions: This pilot study indicated that the multi-user telerehabilitation program is feasible for improving the balance and functional activity similar to conventional therapy in patients with chronic stroke living in LTCFs.

  19. Active tuned mass damper in vehicles. Integrated mass and energy balance; Mechatronische Schwingungstilger in Fahrzeugen. Ganzheitliche Massen- und Energiebilanz

    Energy Technology Data Exchange (ETDEWEB)

    Granzow, Sebastian

    2012-04-02

    The number of mechatronic automotive applications is growing rapidly and becoming more and more important. On the other hand, the automotive industry is faced with the ambitious challenge to significantly reduce CO{sub 2}-emissions. The vehicle mass is as a part of the driving resistance is a starting point. New innovative approaches are required for lightweight constructions. Taking the two aspects together, this leads inevitably to the question: Is it possible to support automotive lightweight construction by using mechatronic systems? The Mechatronic vibration absorber is a combination of a mechanical oscillating system with an electronically controllable force component. This allows a broadband and situation-dependent influence of vehicle vibration behavior. Mechatronic vibration absorbers are suitable to compensate a loss of riding comfort due to a reduction of the body mass. Essential for this is a multidisciplinary simulation environment. The mechatronic vibration absorber, including appropriate control systems, the nonlinear chassis and the elastic body characteristics, inclusive of mutual interactions are mapped in the simulation environment Matlab. In addition to the representation of the oscillating vehicle the determination of the total energy requirements is necessary. To achieve a CO{sub 2}-reduction target, the overall energy balance of lightweight and the electrical vibration absorber energy, which is offered by the vehicle, is required. The question of the real vibration absorber energy needs to be discussed in the context of the individual driving behavior. Ultimately, the overall energy balance is inherently dependent of the individual driving behavior.

  20. New findings on the onset of thermal disassembly in spallation reactions

    International Nuclear Information System (INIS)

    Napolitani, P.

    2004-09-01

    Thermal multifragmentation is the process of multi body disassembly of a hot nucleus when the excitation is almost purely thermal i.e. dynamical effects like compression (characteristic of ion-ion collisions at Fermi energy) are negligible. Suited reactions are proton induced collision or ion-ion abrasion at relativistic incident energy. Thus we measured four systems at FRS (Fragment separator, GSI, Darmstadt) in inverse kinematics: Fe 56 +p, Fe 56 +Ti(nat), Xe 136 +p, Xe 136 +Ti(nat) a 1 A*GeV. The inverse kinematics allows to observe all particles without any threshold in energy. This is a great advantage compared to experiments in direct kinematics, because only in inverse kinematics it is possible to obtain complete velocity spectra (without a hole for low velocities) for fully identified isotopes. The complex shape of the velocity spectra allows to identify the different deexcitation channels and it clearly shows the transition from a chaotic-dominated process (Gaussian cloud in velocity space) to a direct Coulomb- (or eventually expansion-) dominated process (shell of a sphere in velocity space). Different possible descriptions of the reaction process are discussed, based either on asymmetric fission or multifragmentation. The resulting physical picture is especially interesting for the Fe 56 +p, and Xe 136 +p systems: proton induced collisions could result in the split of the system in two or more fragments due to a fast break-up process. In this case, the configuration of the break-up partition is very asymmetric. The discussion will be extended to other characteristics, like the restoring of nuclear structure features in the isotopic production and the temperature dependence of the isotopic composition of the residues. (author)

  1. Sodium removal disassembly and examination of the Fermi secondary sodium pump

    International Nuclear Information System (INIS)

    Maffei, H.P.; Funk, C.W.; Ballif, J.L.

    1974-01-01

    The Fermi secondary pump is a centrifugal single stage design. The pump had been operated more than 42,000 hours between 450 and 800 0 F. Sodium was drained from the pump in 1973 and the system was back filled with carbon dioxide. The pump was fabricated for 2.25 Cr-1 Mo Croloy steel. Prior to cleaning the pump was inerted and heated with 150 0 F nitrogen using the pump casing as the containment vessel. The water-vapor-nitrogen process was used in three increasing stages of water concentration. The hydrogen concentration in the discharge line was followed as an indicator of the sodium-water reaction rate. Upon completion of the hydrogen evolution, the pump was rinsed several times with hot water. Six pounds of sodium were removed from the pump during a process cycle of 79 hours including rinsing. The maximum pump temperature recorded was 175 0 F with no variation exceeding 10 0 F. The hydrogen concentration in the effluent provided a very satisfactory index for control of the reaction by adjustment of the water-vapor concentration feed to the system. Rinsing effectiveness was limited by a pool of water in the volute that was not drainable with the available system hook up. Sodium and its compounds were removed from all internal surfaces that could be observed by the first stage of disassembly. All such surfaces were coated with a black deposit. Areas above the sodium liquid level were coated with a vermillion colored oxide. Sodium was found on the (1) threads of the impeller nut lock screw, (2) impeller nut-tapered shaft interface, and (3) vapor deposited sodium was found in the oil seal

  2. Integration of balance and strength training into daily life activity to reduce rate of falls in older people (the LiFE study): randomised parallel trial.

    Science.gov (United States)

    Clemson, Lindy; Fiatarone Singh, Maria A; Bundy, Anita; Cumming, Robert G; Manollaras, Kate; O'Loughlin, Patricia; Black, Deborah

    2012-08-07

    To determine whether a lifestyle integrated approach to balance and strength training is effective in reducing the rate of falls in older, high risk people living at home. Three arm, randomised parallel trial; assessments at baseline and after six and 12 months. Randomisation done by computer generated random blocks, stratified by sex and fall history and concealed by an independent secure website. Residents in metropolitan Sydney, Australia. Participants aged 70 years or older who had two or more falls or one injurious fall in past 12 months, recruited from Veteran's Affairs databases and general practice databases. Exclusion criteria were moderate to severe cognitive problems, inability to ambulate independently, neurological conditions that severely influenced gait and mobility, resident in a nursing home or hostel, or any unstable or terminal illness that would affect ability to do exercises. Three home based interventions: Lifestyle integrated Functional Exercise (LiFE) approach (n=107; taught principles of balance and strength training and integrated selected activities into everyday routines), structured programme (n=105; exercises for balance and lower limb strength, done three times a week), sham control programme (n=105; gentle exercise). LiFE and structured groups received five sessions with two booster visits and two phone calls; controls received three home visits and six phone calls. Assessments made at baseline and after six and 12 months. Primary measure: rate of falls over 12 months, collected by self report. Secondary measures: static and dynamic balance; ankle, knee and hip strength; balance self efficacy; daily living activities; participation; habitual physical activity; quality of life; energy expenditure; body mass index; and fat free mass. After 12 months' follow-up, we recorded 172, 193, and 224 falls in the LiFE, structured exercise, and control groups, respectively. The overall incidence of falls in the LiFE programme was 1.66 per person

  3. Biomechanical assessment of dynamic balance: Specificity of different balance tests.

    Science.gov (United States)

    Ringhof, Steffen; Stein, Thorsten

    2018-04-01

    Dynamic balance is vitally important for most sports and activities of daily living, so the assessment of dynamic stability has become an important issue. In consequence, a large number of balance tests have been developed. However, it is not yet known whether these tests (i) measure the same construct and (ii) can differentiate between athletes with different balance expertise. We therefore studied three common dynamic balance tests: one-leg jump landings, Posturomed perturbations and simulated forward falls. Participants were 24 healthy young females in regular training in either gymnastics (n = 12) or swimming (n = 12). In each of the tests, the participants were instructed to recover balance as quickly as possible. Dynamic stability was computed by time to stabilization and margin of stability, deduced from force plates and motion capture respectively. Pearson's correlations between the dynamic balance tests found no significant associations between the respective dynamic stability measures. Furthermore, independent t-tests indicated that only jump landings could properly distinguish between both groups of athletes. In essence, the different dynamic balance tests applied did not measure the same construct but rather task-specific skills, each of which depends on multifactorial internal and external constraints. Our study therefore contradicts the traditional view of considering balance as a general ability, and reinforces that dynamic balance measures are not interchangeable. This highlights the importance of selecting appropriate balance tests. Copyright © 2018 Elsevier B.V. All rights reserved.

  4. Balancing Risk

    DEFF Research Database (Denmark)

    Nygaard, Lene; Rossen, Camilla Blach; Buus, Niels

    2015-01-01

    This study explored how eight pregnant women diagnosed with depression managed the decision whether or not to take antidepressants during pregnancy. In total, 11 interviews were conducted and analysed by means of constructivist grounded theory. The major category constructed was Balancing risk......, with two minor categories: Assessing depression and antidepressants and Evaluating the impact of significant others. The participants tried to make the safest decision, taking all aspects of their life into consideration. They described successful decision-making in the context of managing social norms...

  5. Mass balance of arsenic fluxes in rivers impacted by gold mining activities in Paracatu (Minas Gerais State, Brazil).

    Science.gov (United States)

    Bidone, Edison; Cesar, Ricardo; Santos, Maria Carla; Sierpe, Ricardo; Silva-Filho, Emmanuel Vieira; Kutter, Vinicius; Dias da Silva, Lílian I; Castilhos, Zuleica

    2018-03-01

    Arsenic (As) is a dangerous and carcinogenic element and drinking water is its main pathway of human exposure. Gold mines are widely recognized as important sources of As pollution. This work proposes the assessment of As distribution along watersheds surrounding "Morro do Ouro" gold mine (Paracatu, southeastern Brazil). A balance approach between filtered As fluxes (As river segments was applied. Ultrafiltration procedure was used to categorize As into the following classes: particulate > 0.1 μm, colloidal  10 kDa, dissolved  1 kDa, and truly dissolved river segment that suggests As accumulation in sediments along the rivers in both urban and rural areas, mainly due to SPM sedimentation and sorption by Fe oxyhydroxides. Ultrafiltration shattering showed concentrations of decreasing As with particle size; the SPM load (> 0.1 μm) was almost one order higher to dissolved load (< 1 kDa).

  6. 电动汽车锂电池组主动均衡的研究%Research of lithium battery active balancing for electric vehicle

    Institute of Scientific and Technical Information of China (English)

    周西峰; 贾星远; 郭前岗

    2015-01-01

    目前,锂电池组已广泛应用于电动汽车领域,为了延长锂电池组的使用寿命及确保其安全性,需要设计简单有效的均衡方法来减小单体电池间的不一致性,从而保障电动汽车的性能和安全。针对被动均衡方式效率低、发热大、耗电多的不足,研究了锂电池组主动均衡控制方法,该方法采用了双向多变压器均衡电路,由MOS 管进行开关控制,实现电池模块中任意单体的双向均衡。并对该均衡方案在 LTspiceIV 上进行了仿真实验验证,结果表明该均衡方案均衡效果良好,达到了设计要求。%Currently, lithium batteries have been widely used in the field of electric vehicles. In order to extend the life and make the safety of lithium batteries, it is necessary to design a simple and effective way to reduce inconsistencies between the cells, thereby protecting the electric vehicle performance and safety. For passive balanced manner has the shortages of low efficiency , large heat, consume more battery power, we studied the lithium active balance control method that uses a two-way multi-transformer balanced circuit, switching is controlled by a MOS transistor, to achieve a balanced two-way cell module of any monomer. And the simulation experiments for the equalization program are done in the platform of LTspiceIV. The results show that the proposed balanced program works well, meets the design requirements.

  7. Nucleolus disassembly and distribution of segregated nucleolar material in prophase of root-tip meristematic cells in Triticum aestivum L.

    Directory of Open Access Journals (Sweden)

    Wang Jianyue

    2015-01-01

    Full Text Available This paper presents details of the process of nucleolar disassembly, studied by conventional transmission electron microscopy (TEM in wheat root cells. In early prophase, chromatin condensation and irregular nucleolar morphology are observed, with many small particles appearing around the nucleolus. In middle prophase, the nucleolus radiates outwards; in late prophase, the fine structure of the nucleolus disappears and nucleolar material diffuses away. Using “en bloc” silver-staining to distinguish between nucleoli and chromatin, we observed that the dispersed nucleolar material aggregates around the chromatin, forming a sheath-like perichromosomal structure that coats the chromosomes in late prophase.

  8. A novel quantitative model of cell cycle progression based on cyclin-dependent kinases activity and population balances.

    Science.gov (United States)

    Pisu, Massimo; Concas, Alessandro; Cao, Giacomo

    2015-04-01

    Cell cycle regulates proliferative cell capacity under normal or pathologic conditions, and in general it governs all in vivo/in vitro cell growth and proliferation processes. Mathematical simulation by means of reliable and predictive models represents an important tool to interpret experiment results, to facilitate the definition of the optimal operating conditions for in vitro cultivation, or to predict the effect of a specific drug in normal/pathologic mammalian cells. Along these lines, a novel model of cell cycle progression is proposed in this work. Specifically, it is based on a population balance (PB) approach that allows one to quantitatively describe cell cycle progression through the different phases experienced by each cell of the entire population during its own life. The transition between two consecutive cell cycle phases is simulated by taking advantage of the biochemical kinetic model developed by Gérard and Goldbeter (2009) which involves cyclin-dependent kinases (CDKs) whose regulation is achieved through a variety of mechanisms that include association with cyclins and protein inhibitors, phosphorylation-dephosphorylation, and cyclin synthesis or degradation. This biochemical model properly describes the entire cell cycle of mammalian cells by maintaining a sufficient level of detail useful to identify check point for transition and to estimate phase duration required by PB. Specific examples are discussed to illustrate the ability of the proposed model to simulate the effect of drugs for in vitro trials of interest in oncology, regenerative medicine and tissue engineering. Copyright © 2015 Elsevier Ltd. All rights reserved.

  9. A Balanced Scorecard-Based Model for Evaluating E-Learning and Conventional Pedagogical Activities in Nursing

    Science.gov (United States)

    Hovelja, Tomaž; Vavpotic, Damjan; Žvanut, Boštjan

    2016-01-01

    The evaluation of e-learning and conventional pedagogical activities in nursing programmes has focused either on a single pedagogical activity or the entire curriculum, and only on students' or teachers' perspective. The goal of this study was to design and test a novel approach for evaluation of e-learning and conventional pedagogical activities…

  10. Review of Effects of Physical Activity on Strength, Balance, Mobility and ADL Performance in Elderly Subjects with Dementia

    NARCIS (Netherlands)

    Blankevoort, Christiaan G.; van Heuvelen, Marieke J. G.; Boersma, Froukje; Luning, Helga; de Jong, Jeltsje; Scherder, Erik J. A.

    2010-01-01

    Background/Aims: Elderly individuals with dementia are vulnerable for a decline in physical functioning and basic activities of daily living (BADL) which can lead to a decline in autonomy and participation. This study reviews the effect of physical activity on physical functioning and BADL in

  11. The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability.

    Directory of Open Access Journals (Sweden)

    Tobias Wilms

    2017-06-01

    Full Text Available The conserved protein kinase Sch9 is a central player in the nutrient-induced signaling network in yeast, although only few of its direct substrates are known. We now provide evidence that Sch9 controls the vacuolar proton pump (V-ATPase to maintain cellular pH homeostasis and ageing. A synthetic sick phenotype arises when deletion of SCH9 is combined with a dysfunctional V-ATPase, and the lack of Sch9 has a significant impact on cytosolic pH (pHc homeostasis. Sch9 physically interacts with, and influences glucose-dependent assembly/disassembly of the V-ATPase, thereby integrating input from TORC1. Moreover, we show that the role of Sch9 in regulating ageing is tightly connected with V-ATPase activity and vacuolar acidity. As both Sch9 and the V-ATPase are highly conserved in higher eukaryotes, it will be interesting to further clarify their cooperative action on the cellular processes that influence growth and ageing.

  12. Synaptic excitation in spinal motoneurons alternates with synaptic inhibition and is balanced by outward rectification during rhythmic motor network activity

    DEFF Research Database (Denmark)

    Guzulaitis, Robertas; Hounsgaard, Jorn

    2017-01-01

    channels. Intrinsic outward rectification facilitates spiking by focusing synaptic depolarization near threshold for action potentials. By direct recording of synaptic currents, we also show that motoneurons are activated by out-of-phase peaks in excitation and inhibition during network activity, whereas......Regular firing in spinal motoneurons of red-eared turtles (Trachemys scripta elegans, either sex) evoked by steady depolarization at rest is replaced by irregular firing during functional network activity. The transition caused by increased input conductance and synaptic fluctuations in membrane...... potential was suggested to originate from intense concurrent inhibition and excitation. We show that the conductance increase in motoneurons during functional network activity is mainly caused by intrinsic outward rectification near threshold for action potentials by activation of voltage and Ca2+ gated K...

  13. Foot Problems in Older Adults Associations with Incident Falls, Frailty Syndrome, and Sensor-Derived Gait, Balance, and Physical Activity Measures.

    Science.gov (United States)

    Muchna, Amy; Najafi, Bijan; Wendel, Christopher S; Schwenk, Michael; Armstrong, David G; Mohler, Jane

    2018-03-01

    Research on foot problems and frailty is sparse and could advance using wearable sensor-based measures of gait, balance, and physical activity (PA). This study examined the effect of foot problems on the likelihood of falls, frailty syndrome, motor performance, and PA in community-dwelling older adults. Arizona Frailty Cohort Study participants (community-dwelling adults aged ≥65 years without baseline cognitive deficit, severe movement disorders, or recent stroke) underwent Fried frailty and foot assessment. Gait, balance (bipedal eyes open and eyes closed), and spontaneous PA over 48 hours were measured using validated wearable sensor technologies. Of 117 participants, 41 (35%) were nonfrail, 56 (48%) prefrail, and 20 (17%) frail. Prevalence of foot problems (pain, peripheral neuropathy, or deformity) increased significantly as frailty category worsened (any problem: 63% in nonfrail, 80% in prefrail [odds ratio (OR) = 2.0], and 95% in frail [OR = 8.3]; P = .03 for trend) due to associations between foot problems and both weakness and exhaustion. Foot problems were associated with fear of falling but not with fall history or incident falls over 6 months. Foot pain and peripheral neuropathy were associated with lower gait speed and stride length; increased double support time; increased mediolateral sway of center of mass during walking, age adjusted; decreased eyes open sway of center of mass and ankle during quiet standing, age adjusted; and lower percentage walking, percentage standing, and total steps per day. Foot problems were associated with frailty level and decreased motor performance and PA. Wearable technology is a practical way to screen for deterioration in gait, balance, and PA that may be associated with foot problems. Routine assessment and management of foot problems could promote earlier intervention to retain motor performance and manage fear of falling in older adults, which may ultimately improve healthy aging and reduce risk of frailty.

  14. Clinimetric properties of the Tinetti Mobility Test, Four Square Step Test, Activities-specific Balance Confidence Scale, and spatiotemporal gait measures in individuals with Huntington's disease.

    Science.gov (United States)

    Kloos, Anne D; Fritz, Nora E; Kostyk, Sandra K; Young, Gregory S; Kegelmeyer, Deb A

    2014-09-01

    Individuals with Huntington's disease (HD) experience balance and gait problems that lead to falls. Clinicians currently have very little information about the reliability and validity of outcome measures to determine the efficacy of interventions that aim to reduce balance and gait impairments in HD. This study examined the reliability and concurrent validity of spatiotemporal gait measures, the Tinetti Mobility Test (TMT), Four Square Step Test (FSST), and Activities-specific Balance Confidence (ABC) Scale in individuals with HD. Participants with HD [n = 20; mean age ± SD=50.9 ± 13.7; 7 male] were tested on spatiotemporal gait measures and the TMT, FSST, and ABC Scale before and after a six week period to determine test-retest reliability and minimal detectable change (MDC) values. Linear relationships between gait and clinical measures were estimated using Pearson's correlation coefficients. Spatiotemporal gait measures, the TMT total and the FSST showed good to excellent test-retest reliability (ICC > 0.75). MDC values were 0.30 m/s and 0.17 m/s for velocity in forward and backward walking respectively, four points for the TMT, and 3s for the FSST. The TMT and FSST were highly correlated with most spatiotemporal measures. The ABC Scale demonstrated lower reliability and less concurrent validity than other measures. The high test-retest reliability over a six week period and concurrent validity between the TMT, FSST, and spatiotemporal gait measures suggest that the TMT and FSST may be useful outcome measures for future intervention studies in ambulatory individuals with HD. Copyright © 2014 Elsevier B.V. All rights reserved.

  15. Sport-specific balance.

    Science.gov (United States)

    Zemková, Erika

    2014-05-01

    This review includes the latest findings based on experimental studies addressing sport-specific balance, an area of research that has grown dramatically in recent years. The main objectives of this work were to investigate the postural sway response to different forms of exercise under laboratory and sport-specific conditions, to examine how this effect can vary with expertise, and to provide examples of the association of impaired balance with sport performance and/or increasing risk of injury. In doing so, sports where body balance is one of the limiting factors of performance were analyzed. While there are no significant differences in postural stability between athletes of different specializations and physically active individuals during standing in a standard upright position (e.g., bipedal stance), they have a better ability to maintain balance in specific conditions (e.g., while standing on a narrow area of support). Differences in magnitude of balance impairment after specific exercises (rebound jumps, repeated rotations, etc.) and mainly in speed of its readjustment to baseline are also observed. Besides some evidence on an association of greater postural sway with the increasing risk of injuries, there are many myths related to the negative influence of impaired balance on sport performance. Though this may be true for shooting or archery, findings have shown that in many other sports, highly skilled athletes are able to perform successfully in spite of increased postural sway. These findings may contribute to better understanding of the postural control system under various performance requirements. It may provide useful knowledge for designing training programs for specific sports.

  16. Tritium activity balance in hairless rats following skin-contact exposure to tritium-gas-contaminated stainless-steel surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Trivedi, A

    1994-06-01

    Studies using animals and human volunteers have demonstrated that the dosimetry for skin-contact exposure to contaminated metal surfaces differs from that for the intake of tritiated water or tritium gas. However, despite the availability of some information on the dosimetry for skin-contact with tritium-gas-contaminated metal surfaces, uncertainties in estimating skin doses remain, because of poor accounting for the applied tritium activity in the body (Eakins et al., 1975; Trivedi, 1993). Experiments on hairless rats were performed to account for the tritium activity applied onto the skin. Hairless rats were contaminated through skin-contact exposure to tritium-gas-contaminated stainless-steel planchets. The activity in the first smear was about 35% of the total removable activity (measured by summing ten consecutive swipes). The amount of tritium applied onto the skin can be approximated by estimating the tritium activity in the first smear removed form the contaminated surfaces. 87 {+-} 9% of the transferred tritium was retained in the exposed skin 30 min post-exposure. 30 min post exposure, the unexposed skin and the carcass retained 8 {+-} 6% and 3 {+-} 2% of the total applied tritium activity, respectively. The percentage of tritium evolved from the body or breathed out was estimated to be 2 {+-} 1% of the total applied activity 30 min post-exposure. It is recommended that to evaluate accurately the amount of tritium transferred to the skin, alternative measurement approaches are required that can directly account for the transferred activity onto the skin. 15 refs., 13 tabs., 7 figs.

  17. Balancing priorities

    DEFF Research Database (Denmark)

    Mønsted, Troels; Johansen, Andreas Kaas; Lauridsen, Frederik Vahr Bjarnø

    2016-01-01

    Within elder care, an increased distribution of care poses strong requirements on the ability of health providers, to coordinate their activities across organizational boundaries. However, existing care administration systems do not offer sufficient support for collaboration and coordination among...... administration systems. Overall, we found that caregivers at the care center fulfill a crucial role in prioritizing the scheduled activities in cases where opposed interests occur, which indicates a need for a care administration system, that not only supports the meticulous planning of activities...

  18. Effect Considering of Mild and Moderate Visual and Auditory Impairment on the Activities of Daily Living and Balance Performance in the Elderly

    Directory of Open Access Journals (Sweden)

    Mina Hosseini

    2010-01-01

    Conclusion: Even mild and moderate auditory impairment can cause disability in the basic ADL. If mild and moderate auditory impairment exist simultaneously with visual impairment, the person had balance disability. Auditory impairment didn't have any effect on balance.

  19. Viral RNA-Unprimed Rig-I Restrains Stat3 Activation in the Modulation of Regulatory T Cell/Th17 Cell Balance.

    Science.gov (United States)

    Yang, Hui; Guo, He-Zhou; Li, Xian-Yang; Lin, Jian; Zhang, Wu; Zhao, Jun-Mei; Zhang, Hong-Xin; Chen, Sai-Juan; Chen, Zhu; Zhu, Jiang

    2017-07-01

    Innate immunity activation by viral RNA-primed retinoid acid inducible gene-I (Rig-I) in CD4 + T cells antagonizes TGFβ signaling to suppress the differentiation of regulatory T cells (Tregs). However, how viral RNA-unliganded Rig-I (apo-Rig-I) modulates Treg generation remains unclear. In this article, we show that, in the absence of viral infection, Treg differentiation of Rig-I -/- CD4 + T cells was compromised, in the presence of increased generation of Th17 cells and overactivation of Stat3, a critical regulator tilting the Treg/Th17 cell balance. Mechanistically, apo-Rig-I physically associates with Stat3, thereby inhibiting Jak1's association with Stat3 while facilitating Shp2's association to inhibit p-Stat3 levels. Interestingly, inhibition of Stat3 ameliorates the Treg/Th17 imbalance and the colitis observed in Rig-I -/- mice. Collectively, these results uncover an independent functional contribution of the apo-Rig-I/Stat3 interaction in the maintenance of Treg/Th17 cell balance. Copyright © 2017 by The American Association of Immunologists, Inc.

  20. Effect of thermal pretreatment on the biogas production and microbial communities balance during anaerobic digestion of urban and industrial waste activated sludge.

    Science.gov (United States)

    Ennouri, Hajer; Miladi, Baligh; Diaz, Soraya Zahedi; Güelfo, Luis Alberto Fernández; Solera, Rosario; Hamdi, Moktar; Bouallagui, Hassib

    2016-08-01

    The effect of thermal pre-treatment on the microbial populations balance and biogas production was studied during anaerobic digestion of waste activated sludge (WAS) coming from urban (US: urban sludge) and industrial (IS: industrial sludge) wastewater treatment plants (WWTP). The highest biogas yields of 0.42l/gvolatile solid (VS) removed and 0.37l/gVS removed were obtained with urban and industrial sludge pre-treated at 120°C, respectively. Fluorescent in situ hybridization (FISH) was used to quantify the major Bacteria and Archaea groups. Compared to control trails without pretreatment, Archaea content increased from 34% to 86% and from 46% to 83% for pretreated IS and US, respectively. In fact, the thermal pre-treatment of WAS enhanced the growth of hydrogen-using methanogens (HUMs), which consume rapidly the H2 generated to allow the acetogenesis. Therefore, the stable and better performance of digesters was observed involving the balance and syntrophic associations between the different microbial populations. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. Adaptations of prefrontal brain activity, executive functions, and gait in healthy elderly following exergame and balance training: A randomized-controlled study

    Directory of Open Access Journals (Sweden)

    Alexandra Schättin

    2016-11-01

    Full Text Available During aging, the prefrontal cortex (PFC undergoes age-dependent neuronal changes influencing cognitive and motor functions. Motor-learning interventions are hypothesized to ameliorate motor and cognitive deficits in older adults. Especially, video game-based physical exercise might have the potential to train motor in combination with cognitive abilities in older adults. The aim of this study was to compare conventional balance training with video game-based physical exercise, a so-called exergame, on the relative power (RP of electroencephalographic (EEG frequencies over the PFC, executive function (EF, and gait performance. Twenty-seven participants (mean age 79.2 ± 7.3 years were randomly assigned to one of two groups. All participants completed 24 trainings including three times a 30min session/week. The EEG measurements showed that theta RP significantly decreased in favor of the exergame group (L(14 = 6.23, p = 0.007. Comparing pre- vs. post-test, EFs improved both within the exergame (working memory: z = -2.28, p = 0.021; divided attention auditory: z = -2.51, p = 0.009; divided attention visual: z = -2.06, p = 0.040; go/no-go: z = -2.55, p = 0.008; set-shifting: z = -2.90, p = 0.002 and within the balance group (set-shifting: z = -2.04, p = 0.042. Moreover, spatio-temporal gait parameters primarily improved within the exergame group under dual-task conditions (speed normal walking: z = -2.90, p = 0.002; speed fast walking: z = -2.97, p = 0.001; cadence normal walking: z = -2.97, p = 0.001; stride length fast walking: z = -2.69, p = 0.005 and within the balance group under single-task conditions (speed normal walking: z = -2.54, p = 0.009; speed fast walking: z = -1.98, p = 0.049; cadence normal walking: z = -2.79, p = 0.003. These results indicate that exergame training as well as balance training positively influence prefrontal cortex activity and/or function in varying proportion.

  2. Characterization of spent fuel disassembly hardware and nonfuel bearing components and their relationship to 10 CFR 61

    International Nuclear Information System (INIS)

    Luksic, A.T.

    1987-02-01

    There are a variety of wastes that will be disposed of by the federal waste management system under the Nuclear Waste Policy Act of 1982. The primary waste form is spent nuclear fuel. Currently, this is in the form of fuel assemblies. If the fuel pins are removed from the fuel assembly, as in consolidation, then the fuel pins and the structural portion of the fuel assembly must be considered as separate waste streams. The structural hardware consists of end fittings, grid spacers, water rods (BWR 8 x 8 only), control rod guide tubes (PWR only) and various nuts, washers, springs, etc. These are referred to as spent fuel disassembly (SFD) hardware. There will also be a number of other components which are defined in Appendix E of 10 CFR 961, the standard utility contract. These are referred to as nonfuel-bearing (NFB) components, and include fuel channels (BWR), control rods, fission chambers, neutron sources, thimble plugs, and other components. This paper characterizes spent fuel disassembly (SFD) hardware, and nonfuel-bearing (NFB) components for the most abundant fuel types. The descriptions and figures given are representative for the items described. Many subvariants exist due to design evaluation, which are not covered. This paper also discusses the relationship of these wastes to 10 CFR 61 waste classification

  3. Spiropyran-Decorated SiO₂-Pt Janus Micromotor: Preparation and Light-Induced Dynamic Self-Assembly and Disassembly.

    Science.gov (United States)

    Zhang, Qilu; Dong, Renfeng; Chang, Xueyi; Ren, Biye; Tong, Zhen

    2015-11-11

    The controlled self-assembly of self-propelled Janus micromotors may give the micromotors some potential applications in many fields. In this work, we design a kind of SiO2-Pt Janus catalytic micromotor functionalized by spiropyran (SP) moieties on the surface of the SiO2 hemisphere. The spiropyran-modified SiO2-Pt Janus micromotor exhibits autonomous self-propulsion in the presence of hydrogen peroxide fuel in N,N-dimethylformamide (DMF)/H2O (1:1 in volume) mixture. We demonstrate that the self-propelled Janus micromotors can dynamically assemble into multiple motors because of the electrostatic attractions and π-π stacking between MC molecules induced by UV light irradiation (λ = 365 nm) and also quickly disassemble into mono motors when the light is switched to green light (λ = 520 nm) for the first time. Furthermore, the assembled Janus motors can move together automatically with different motion patterns propelled by the hydrogen peroxide fuels upon UV irradiation. The work provides a new approach not only to the development of the potential application of Janus motors but also to the fundamental science of reversible self-assembly and disassembly of Janus micromotors.

  4. Technical review of WSRC-TR-93-614 criticality safety evaluation for disassembly basin sand filter

    International Nuclear Information System (INIS)

    Reed, R.L.

    1994-01-01

    The study documented in WSRC-TR-93-614 performed an evaluation of the criticality potential associated with the Disassembly Basin Sand Filter for K and L Areas. The document reviewed incorporated results of calculations documented in the engineering calculation N-CLC-K-00151. Analyses of the contents of disassembly basin sludge has indicated that the sludge contains fissile material in excess of subcritical mass limits as specified in ANSI/ANS standards. Previous studies had determined that the fissile material can not collect into a critical configuration in the basin. Since the sand filter is intended to remove suspended particles from the basin water and could serve as a mechanism to collect the fissile material into a critical configuration, the study examined conditions under which criticality could occur in the sand filter. The study shows that criticality is not considered possible in the sand filter. This review emphasized the technical accuracy and presentation of the evaluation. The evaluation was also examined for the elements required for NCSEs. The review was performed in accordance with the NRTSC technical review requirements and procedures and the E7 Manual technical review requirements. The technical review (per the E7 manual) of the engineering calculation (N-CLC-K-0 1 5 1) was previously performed by this reviewer

  5. 46 CFR 232.4 - Balance sheet accounts.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Balance sheet accounts. 232.4 Section 232.4 Shipping... ACTIVITIES UNIFORM FINANCIAL REPORTING REQUIREMENTS Balance Sheet § 232.4 Balance sheet accounts. (a.... (b) Purpose of balance sheet accounts. The balance sheet accounts are intended to disclose the...

  6. Adrenergic receptors and gastric secretion in dogs. Is a "tonic balance" relationship between vagal and beta 2-adrenergic activity a possibility?

    DEFF Research Database (Denmark)

    Gottrup, F; Hovendal, C; Bech, K

    1984-01-01

    The relative influence of adrenergic receptors on gastric acid secretion in the dog stomach with different vagal activity or "tone" is almost unknown. beta-adrenoceptors seem to be most important for the direct effect of adrenergic stimulation on acid secretion. In this study the effects...... acid secretion was not influenced significantly by beta-blockade. Similar dose-response curves were found for non-vagotomized dogs with high beta 2-adrenergic tone and dogs with low vagal tone (vagotomy) after pentagastrin and histamine stimulated acid secretion. This study indicates...... that a counterbalance between beta 2-adrenergic and cholinergic vagal tone exists. A "tonic balance theory" is suggested and is probably involved in the resulting acid secretion after vagotomy....

  7. Electrolyte Balance of the Inner Ear Investigated by Neutron Activation Analysis of the Sodium and Potassium Content

    International Nuclear Information System (INIS)

    Ördögh, Mary; Miriszlai, E.

    1967-01-01

    Even the few experimental data that have been obtained from investigations of the inner ear are an important contribution to our biochemical knowledge of the sense organs. The apparent discrepancies between some experimental results have prompted comparative studies on the sodium and potassium concentrations in the inner-ear fluids, the liquor cerebrospinalis, the mammalian and human serum. The results of these studies are expected to give a good approximation of the intracellular and extracellular electrolyte concentrations and to yield important information on the physiological and pathological conditions of the inner ear as well as on the mechanism of hearing. The experimental material is obtained from guinea pigs by penetration through the round window (fenestra rotunda). The sodium and potassium content is determined by neutron activation analysis. Potassium is precipitated from the irradiated samples by sodium tetraphenyl borate reagent, so that the sodium activity retained by the filtrate can be directly counted. Since a single precipitation of potassium does not yield end products free from sodium contamination, the precipitate is dissolved in acetone and precipitated again with sodium tetraphenyl borate. The product of the second precipitation is radiochemically pure. In simultaneous experiments, potassium was separated from the much higher sodium activity by isotopic exchange. The irradiated sample is added to an experimentally determined inactive potassium tetraphenyl borate precipitate that adsorbs the total potassium activity present without adsorbing any sodium. The separation of potassium by isotopic exchange has the advantage of yielding in a single step a sufficiently pure product without any sodium contamination. For comparison, sodium and potassium were also determined by flame photometry. (author)

  8. Conformational changes in a hyperthermostable glycoside hydrolase: enzymatic activity is a consequence of the loop dynamics and protonation balance.

    Directory of Open Access Journals (Sweden)

    Leandro C de Oliveira

    Full Text Available Endo-β-1, 4-mannanase from Thermotoga petrophila (TpMan is a modular hyperthermostable enzyme involved in the degradation of mannan-containing polysaccharides. The degradation of these polysaccharides represents a key step for several industrial applications. Here, as part of a continuing investigation of TpMan, the region corresponding to the GH5 domain (TpManGH5 was characterized as a function of pH and temperature. The results indicated that the enzymatic activity of the TpManGH5 is pH-dependent, with its optimum activity occurring at pH 6. At pH 8, the studies demonstrated that TpManGH5 is a molecule with a nearly spherical tightly packed core displaying negligible flexibility in solution, and with size and shape very similar to crystal structure. However, TpManGH5 experiences an increase in radius of gyration in acidic conditions suggesting expansion of the molecule. Furthermore, at acidic pH values, TpManGH5 showed a less globular shape, probably due to a loop region slightly more expanded and flexible in solution (residues Y88 to A105. In addition, molecular dynamics simulations indicated that conformational changes caused by pH variation did not change the core of the TpManGH5, which means that only the above mentioned loop region presents high degree of fluctuations. The results also suggested that conformational changes of the loop region may facilitate polysaccharide and enzyme interaction. Finally, at pH 6 the results indicated that TpManGH5 is slightly more flexible at 65°C when compared to the same enzyme at 20°C. The biophysical characterization presented here is well correlated with the enzymatic activity and provide new insight into the structural basis for the temperature and pH-dependent activity of the TpManGH5. Also, the data suggest a loop region that provides a starting point for a rational design of biotechnological desired features.

  9. Design performances and chemistry program supporting the FA3/UK-EPR (TM) Activity Management: Experience and Modelling Balance

    International Nuclear Information System (INIS)

    Tigeras, A.; Bachet, M.; Bremmes, O.; Berger, M.; Clinard, M.H.; Jolivet, P.; Chahma, F.

    2012-01-01

    Several methodologies have been applied to evaluate the source term in the primary circuit and to define the appropriate chemistry conditioning for the EPR reactor. These methodologies are based on nuclear power plant (NPP) feedback experience, laboratory data and modelling considerations. It is concluded that the activity risks are understood and can be managed with EPR design options. A strategy for the chemical conditioning of the primary coolant has been defined through the specifications for 3 parameters: pH, Zn and H 2 whose target and limit values are based on NPP feedback, international experimental data from laboratory tests, theoretical studies and numerical simulations. The material inventory selected for the primary components will allow low dose rates and low crud formation despite the high power level of the EPR reactor

  10. Effects of easy-to-use protein-rich energy bar on energy balance, physical activity and performance during 8 days of sustained physical exertion.

    Directory of Open Access Journals (Sweden)

    Minna M Tanskanen

    Full Text Available BACKGROUND: Previous military studies have shown an energy deficit during a strenuous field training course (TC. This study aimed to determine the effects of energy bar supplementation on energy balance, physical activity (PA, physical performance and well-being and to evaluate ad libitum fluid intake during wintertime 8-day strenuous TC. METHODS: Twenty-six men (age 20±1 yr. were randomly divided into two groups: The control group (n = 12 had traditional field rations and the experimental (Ebar group (n = 14 field rations plus energy bars of 4.1 MJ•day(-1. Energy (EI and water intake was recorded. Fat-free mass and water loss were measured with deuterium dilution and elimination, respectively. The energy expenditure was calculated using the intake/balance method and energy availability as (EI/estimated basal metabolic rate. PA was monitored using an accelerometer. Physical performance was measured and questionnaires of upper respiratory tract infections (URTI, hunger and mood state were recorded before, during and after TC. RESULTS: Ebar had a higher EI and energy availability than the controls. However, decreases in body mass and fat mass were similar in both groups representing an energy deficit. No differences were observed between the groups in PA, water balance, URTI symptoms and changes in physical performance and fat-free mass. Ebar felt less hunger after TC than the controls and they had improved positive mood state during the latter part of TC while controls did not. Water deficit associated to higher PA. Furthermore, URTI symptoms and negative mood state associated negatively with energy availability and PA. CONCLUSION: An easy-to-use protein-rich energy bars did not prevent energy deficit nor influence PA during an 8-day TC. The high content of protein in the bars might have induced satiation decreasing energy intake from field rations. PA and energy intake seems to be primarily affected by other factors than energy

  11. The Drosera Extract as an Alternative In Vitro Supplement to Animal Semen: Effects on Bovine Spermatozoa Activity and Oxidative Balance

    Directory of Open Access Journals (Sweden)

    Eva Tvrdá

    2015-05-01

    Full Text Available In vitro storage and processing of animal semen is considered to be a risk factor to spermatozoa activity, possibly leading to reduced fertility and litter sizes following artificial insemination (AI. A variety of substances isolated from natural resources have the potential to exhibit protective or antioxidant properties on the spermatozoon, thus they may extend the lifespan of stored semen. Drosera (Drosera rotundifolia L. has been shown to possess antimicrobial, anti-inflammatory and antioxidant properties, making the plant extract a potential candidate for preserving liquid animal semen during in vitro storage. This study compared the ability of different concentrations of Drosera extract on the motility, viability and superoxide production of bovine spermatozoa during different time periods (0, 2, 6, 12 and 24h of in vitro culture. Spermatozoa motility was assessed using the SpermVisionTM CASA (Computer aided sperm analysis system. Cell viability was examined using the metabolic activity MTT assay and the nitroblue-tetrazolium (NBT test was applied to quantify the intracellular superoxide formation. The CASA analysis revealed that Drosera extract supplementation was able to prevent a rapid decline of spermatozoa motility, especially in the case of concentrations ranging between 1 and 5 mg/mL (P<0.001 with respect to Times 6h, 12h and 24h. At the same time, concentrations ranging between 1 and 10 mg/mL of the extract led to a significant preservation of the cell viability throughout short-term (P<0.05 in case of Time 6h as well as long-term periods of the experiment (P<0.01 with respect to Time 12h, and P<0.001 in case of Time 24h. 10 and 5 mg/mL of the extract exhibited antioxidant characteristics, translated into a significant reduction of the intracellular superoxide production, particularly notable at Times 12h (P<0.01 and 24h (P<0.001. The results indicate that the Drosera extract is capable of delaying the damage inflicted to the

  12. Nucleolus disassembly in mitosis and apoptosis: dynamic redistribution of phosphorylated-c-Myc, fibrillarin and Ki-67

    Directory of Open Access Journals (Sweden)

    C Soldani

    2009-06-01

    Full Text Available The nucleolus may undergo disassembly either reversibly during mitosis, or irreversibly in apoptosis, thus allowing the redistribution of the nucleolar proteins.We investigated here by immunocytochemistry the fate of three representative proteins, namely phosphorylated c-Myc, fibrillarin and Ki-67, and found that they behave independently in both processes: they relocate in distinct compartments during mitosis, whereas during apoptosis they may either be cleaved (Ki-67 or be extruded into the cytoplasm with a different kinetics and following an ordered, non chaotic program. The separation of these nucleolar proteins which occurs in early apoptotic nuclei continues also in the cytoplasm, and culminates in the final formation of apoptotic blebs containing different nucleolar proteins: this evidence confirms that the apoptotic bodies may be variable in size, content and surface reactivity, and include heterogeneous aggregates of nuclear proteins and/or nucleic acids.

  13. Active Ingredients of Epimedii Folium and Ligustri Lucidi Fructus Balanced GR/HSP90 to Improve the Sensitivity of Asthmatic Rats to Budesonide

    Directory of Open Access Journals (Sweden)

    Xiufeng Tang

    2017-01-01

    Full Text Available This study aimed to investigate the possible molecular mechanisms of active ingredients of Epimedii Folium (EF and Ligustri Lucidi Fructus (LLF combined with Budesonide (Bun in asthmatic rats. Rats were divided into 5 groups, including normal group, asthma model group, Bun group, group of active ingredients of EL and LLF (EL, and group of coadministration of Bun with EL (Bun&EL. The asthmatic model was prepared by ovalbumin sensitizing and challenging. Lymphocyte apoptosis, GR protein and binding, and the protein and mRNA of GRα, GRβ, and HSP90 were tested. The results showed that Bun&EL ① markedly increased lymphocyte apoptosis, GR and HSP90 protein, and GR binding in BALF and ② enhanced the expressions of GRα and HSP90 and the ratio of GRα to GRβ or to HSP90 both in protein and in mRNA levels in lung, ③ while decrease occurred in GRβ mRNA and the mRNA ratio of GRβ to HSP90 compared with asthma or Bun group. Moreover, there was a significant correlation between GRα and GRβ in protein level, or between GRα and HSP90 both in protein and in mRNA levels. EL may effectively enhance the sensitivity of asthmatic rats to Bun via balancing GR/HSP90. And these findings will be beneficial for the treatment of asthma in the future.

  14. The neighborhood energy balance equation: does neighborhood food retail environment + physical activity environment = obesity? The CARDIA study.

    Directory of Open Access Journals (Sweden)

    Janne Boone-Heinonen

    Full Text Available Recent obesity prevention initiatives focus on healthy neighborhood design, but most research examines neighborhood food retail and physical activity (PA environments in isolation. We estimated joint, interactive, and cumulative impacts of neighborhood food retail and PA environment characteristics on body mass index (BMI throughout early adulthood.We used cohort data from the Coronary Artery Risk Development in Young Adults (CARDIA Study [n=4,092; Year 7 (24-42 years, 1992-1993 followed over 5 exams through Year 25 (2010-2011; 12,921 person-exam observations], with linked time-varying geographic information system-derived neighborhood environment measures. Using regression with fixed effects for individuals, we modeled time-lagged BMI as a function of food and PA resource density (counts per population and neighborhood development intensity (a composite density score. We controlled for neighborhood poverty, individual-level sociodemographics, and BMI in the prior exam; and included significant interactions between neighborhood measures and by sex. Using model coefficients, we simulated BMI reductions in response to single and combined neighborhood improvements. Simulated increase in supermarket density (from 25(th to 75(th percentile predicted inter-exam reduction in BMI of 0.09 kg/m(2 [estimate (95% CI: -0.09 (-0.16, -0.02]. Increasing commercial PA facility density predicted BMI reductions up to 0.22 kg/m(2 in men, with variation across other neighborhood features [estimate (95% CI range: -0.14 (-0.29, 0.01 to -0.22 (-0.37, -0.08]. Simultaneous increases in supermarket and commercial PA facility density predicted inter-exam BMI reductions up to 0.31 kg/m(2 in men [estimate (95% CI range: -0.23 (-0.39, -0.06 to -0.31 (-0.47, -0.15] but not women. Reduced fast food restaurant and convenience store density and increased public PA facility density and neighborhood development intensity did not predict reductions in BMI.Findings suggest that

  15. upSET, the Drosophila homologue of SET3, Is Required for Viability and the Proper Balance of Active and Repressive Chromatin Marks

    Directory of Open Access Journals (Sweden)

    Kyle A. McElroy

    2017-02-01

    Full Text Available Chromatin plays a critical role in faithful implementation of gene expression programs. Different post-translational modifications (PTMs of histone proteins reflect the underlying state of gene activity, and many chromatin proteins write, erase, bind, or are repelled by, these histone marks. One such protein is UpSET, the Drosophila homolog of yeast Set3 and mammalian KMT2E (MLL5. Here, we show that UpSET is necessary for the proper balance between active and repressed states. Using CRISPR/Cas-9 editing, we generated S2 cells that are mutant for upSET. We found that loss of UpSET is tolerated in S2 cells, but that heterochromatin is misregulated, as evidenced by a strong decrease in H3K9me2 levels assessed by bulk histone PTM quantification. To test whether this finding was consistent in the whole organism, we deleted the upSET coding sequence using CRISPR/Cas-9, which we found to be lethal in both sexes in flies. We were able to rescue this lethality using a tagged upSET transgene, and found that UpSET protein localizes to transcriptional start sites (TSS of active genes throughout the genome. Misregulated heterochromatin is apparent by suppressed position effect variegation of the wm4 allele in heterozygous upSET-deleted flies. Using nascent-RNA sequencing in the upSET-mutant S2 lines, we show that this result applies to heterochromatin genes generally. Our findings support a critical role for UpSET in maintaining heterochromatin, perhaps by delimiting the active chromatin environment.

  16. Changes in hormonal balance and meristematic activity in primary root tips on the slowly rotating clinostat and their effect on the development of the rapeseed root system.

    Science.gov (United States)

    Aarrouf, J; Schoevaert, D; Maldiney, R; Perbal, G

    1999-04-01

    The morphometry of the root system, the meristematic activity and the level of indole-3-acetic acid (IAA), abscisic acid (ABA) and zeatin in the primary root tips of rapeseed seedlings were analyzed as functions of time on a slowly rotating clinostat (1 rpm) or in the vertical controls (1 rpm). The fresh weight of the root system was 30% higher throughout the growth period (25 days) in clinorotated seedlings. Morphometric analysis showed that the increase in biomass on the clinostat was due to greater primary root growth, earlier initiation and greater elongation of the secondary roots, which could be observed even in 5-day-old seedlings. However, after 15 days, the growth of the primary root slowed on the clinostat, whereas secondary roots still grew faster in clinorotated plants than in the controls. At this time, the secondary roots began to be initiated closer to the root tip on the clinostat than in the control. Analysis of the meristematic activity and determination of the levels in IAA, ABA and zeatin in the primary root tips demonstrated that after 5 days on the clinostat, the increased length of the primary root could be the consequence of higher meristematic activity and coincided with an increase in both IAA and ABA concentrations. After 15 days on the clinostat, a marked increase in IAA, ABA and zeatin, which probably reached supraoptimal levels, seems to cause a progressive disturbance of the meristematic cells, during a decrease of primary root growth between 15 and 25 days. These modifications in the hormonal balance and the perturbation of the meristematic activity on the clinostat were followed by a loss of apical dominance, which was responsible for the early initiation of secondary roots, the greater elongation of the root system and the emergence of the lateral roots near the tip of the primary root.

  17. CREB, NF-Y and MEIS1 conserved binding sites are essential to balance Myostatin promoter/enhancer activity during early myogenesis.

    Science.gov (United States)

    Grade, Carla Vermeulen Carvalho; Mantovani, Carolina Stefano; Fontoura, Marina Alves; Yusuf, Faisal; Brand-Saberi, Beate; Alvares, Lúcia Elvira

    2017-10-01

    Myostatin (MSTN) is a strong inhibitor of skeletal muscle growth in human and other vertebrates. Its transcription is controlled by a proximal promoter/enhancer (Mstn P/E) containing a TATA box besides CREB, NF-Y, MEIS1 and FXR transcription factor binding sites (TFBSs), which are conserved throughout evolution. The aim of this work was to investigate the role of these TFBSs on Mstn P/E activity and evaluate the potential of their putative ligands as Mstn trans regulators. Mstn P/E mutant constructs were used to establish the role of conserved TFBSs using dual-luciferase assays. Expression analyses were performed by RT-PCR and in situ hybridization in C2C12 myoblasts and E10.5 mouse embryos, respectively. Our results revealed that CREB, NF-Y and MEIS1 sites are required to balance Mstn P/E activity, keeping Mstn transcription within basal levels during myoblast proliferation. Furthermore, our data showed that NF-Y site is essential, although not sufficient, to mediate Mstn P/E transcriptional activity. In turn, CREB and MEIS1 binding sites seem to depend on the presence of NF-Y site to induce Mstn P/E. FXR appears not to confer any effect on Mstn P/E activity, except in the absence of all other conserved TFBS. Accordingly, expression studies pointed to CREB, NF-Y and MEIS1 but not to FXR factors as possible regulators of Mstn transcription in the myogenic context. Altogether, our findings indicated that CREB, NF-Y and MEIS1 conserved sites are essential to control basal Mstn transcription during early myogenesis, possibly by interacting with these or other related factors.

  18. Evidence of the Disassembly of α-Cyclodextrin-octylamine Inclusion Compounds Conjugated to Gold Nanoparticles via Thermal and Photothermal Effects

    Directory of Open Access Journals (Sweden)

    Nataly Silva

    2016-10-01

    Full Text Available Cyclodextrin (CD molecules form inclusion compounds (ICs, generating dimers that are capable of encapsulating molecules derived from long-chain hydrocarbons. The aim of this study is to evaluate the structural changes experienced by ICs in solution with increasing temperatures. For this, a nuclear magnetic resonance (1H-NMR titration was performed to determinate the stoichiometric α-cyclodextrin (α-CD:octylamine (OA 2:1 and binding constant (k = 2.16 M−2 of ICs. Solution samples of α-CD-OA ICs conjugated with gold nanoparticles (AuNPs were prepared, and 1H-NMR spectra at different temperatures were recorded. Comparatively, 1H-NMR spectra of the sample irradiated with a laser with tunable wavelengths, with plasmons of conjugated AuNPs, were recorded. In this work, we present evidence of the disassembly of ICs conjugated with AuNPs. Thermal studies demonstrated that, at 114 °C, there are reversible rearrangements of the host and guests in the ICs in a solid state. Migration movements of the guest molecules from the CD cavity were monitored via temperature-dependent 1H-NMR, and were verified comparing the chemical shifts of octylamine dissolved in deuterated dimethylsulfoxide (DMSO-d6 with the OA molecule included in α-CD dissolved in the same solvent. It was observed that, at 117 °C, OA exited the α-CD cavity. CD IC dimer disassembly was also observed when the sample was irradiated with green laser light.

  19. Modulation of Potassium Channel Activity in the Balance of ROS and ATP Production by Durum Wheat Mitochondria - An amazing defence tool against hyperosmotic stress

    Directory of Open Access Journals (Sweden)

    Daniela eTrono

    2015-12-01

    hyperosmotic stress (mannitol or NaCl, PmitoKATP was found to be activated by ROS, so inhibiting further large-scale ROS production according to a feedback mechanism; moreover, a stress-activated phospholipase A2 may generate FFAs, further activating the channel. In conclusion, a main property of PmitoKATP is the ability to keep in balance the control of harmful ROS with the mitochondrial/cellular bioenergetics, thus preserving ATP for energetic needs of cell defence under stress.

  20. Cathelicidin (LL-37) and its correlation with pro-oxidant, antioxidant balance and disease activity in systemic lupus erythematosus: a cross-sectional human study.

    Science.gov (United States)

    Sahebari, M; Roshandel, G; Saadati, N; Saghafi, M; Abdolahi, N; Rezaieyazdi, Z

    2017-08-01

    Background Cathelicidin (LL-37), an endogenous antimicrobial peptide, has recently been involved in the pathogenesis of autoimmune diseases. To assess whether LL-37 reflects disease activity, we measured serum levels of it in systemic lupus erythematosus (SLE) patients with active and inactive disease compared to healthy controls. LL-37 was also compared between new and old cases. Moreover, the correlation of LL-37 and pro-oxidant, antioxidant balance (PAB) was measured. Methods The study population consisted of 50 SLE patients and 28 healthy controls. Of those, 39 patients had active and 11 patients had inactive disease. Serum levels of LL-37 were measured by ELISA and PAB values by a special method. Results There was no difference in levels of LL-37 between patients and healthy controls (50.9 ± 20.8 vs. 67.7 ± 43.3 ng/ml, P = 0.31). LL-37 did not correlate with SLEDAI and its items in total patients. LL-37 had a positive correlation with SLEDAI in active patients ( P = 0.01, r = 0.4). In active patients (78% of patients), multivariate regression analysis showed significant negative correlation between LL-37 and C3 ( P = 0.01, standardized beta -0.50). No difference was found in levels of PAB between patients and controls (90.4 ± 34.1 vs. 86.9 ± 25.6 HK, P = 0.4).There was no difference in the levels of PAB between patients with active and inactive disease (93.2 ± 34.1 vs. 80.2 ± 33.7 HK, P = 0.27). No correlation was found between levels of PAB and SLEDAI items and total score. However, a positive correlation between the levels of LL-37 and PAB in SLE patients was found ( r = 0.3, P lupus compared with healthy individuals. LL-37 serum values rose in parallel with SLEDAI in active disease. Positive correlation between serum PAB and LL-37 could be a great achievement of this study that may suggest the role of antioxidants in controlling NETosis.

  1. Een energiebalans programma voor pasgepensioneerden : impact op lichaamssamenstelling, lichamelijke activiteit en voeding = An energy balance intervention at retirement : impact on body composition, physical activity and diet

    NARCIS (Netherlands)

    Werkman, A.M.

    2007-01-01

    background Occupational retirement is a life event that is likely to induce lifestyle changes leading to a positive energy balance, and hence weight gain and accumulation of abdominal fat mass. aims The aims of this thesis are 1) to systematically develop an energy balance intervention

  2. Activation of Neck and Low-Back Muscles Is Reduced with the Use of a Neck Balance System Together with a Lumbar Support in Urban Drivers.

    Directory of Open Access Journals (Sweden)

    Federica Menotti

    Full Text Available Driving is associated with high activation of low-back and neck muscles due to the sitting position and perturbations imposed by the vehicle. The aim of this study was to investigate the use of a neck balance system together with a lumbar support on the activation of low-back and neck muscles during driving. Twelve healthy male subjects (age 32±6.71 years were asked to drive in two conditions: 1 with devices; 2 without devices. During vehicle accelerations and decelerations root mean square (RMS of surface electromyography (sEMG was recorded from the erector spinae, semispinalis capitis and sternocleidomastoid muscles and expressed as a percentage of maximal voluntary contraction (MVC. The pitch of the head was obtained by means of an inertial sensor placed on the subjects' head. A visual analog scale (VAS was used to assess the level of perceived comfort. RMS of the low back muscles was lower with than without devices during both acceleration and deceleration of the vehicle (1.40±0.93% vs 29 2.32±1.90% and 1.88±1.45% vs 2.91±2.33%, respectively, while RMS of neck extensor muscles was reduced only during acceleration (5.18±1.96% vs 5.91±2.16%. There were no differences between the two conditions in RMS of neck flexor muscles, the pitch of the head and the VAS score. The use of these two ergonomic devices is therefore effective in reducing the activation of low-back and neck muscles during driving with no changes in the level of perceived comfort, which is likely due to rebalancing weight on the neck and giving a neutral position to lumbar segments.

  3. Wii Fit balance training or progressive balance training in patients with chronic stroke: a randomised controlled trial

    Science.gov (United States)

    Yatar, Gozde Iyigun; Yildirim, Sibel Aksu

    2015-01-01

    [Purpose] The aim of this study was to compare the effects of Wii Fit balance training (WBT) and progressive balance training (PBT) approaches on balance functions, balance confidence, and activities of daily living in chronic stroke patients. [Subjects] A total of 30 patients were randomized into the WBT (n=15) and PBT (n=15) groups. [Methods] All of the subjects received exercise training based on a neurodevelopemental approach in addition to either Wii Fit or progressive balance training for total of 1 hour a day, 3 days per week for 4 weeks. Primary measurements were static balance function measured with a Wii Balance Board and dynamic balance function assessed with the Berg Balance Scale, Timed Up and Go test, Dynamic Gait Index, and Functional Reach Test. Secondary measures were balance confidence assessed with the Activities-specific Balance Confidence scale and activities of daily living evaluated with the Frenchay Activity Index. [Results] There was not remarkable difference between the two treatments in dynamic balance functions, balance confidence, and activities of daily living. [Conclusion] Although both of the approaches were found to be effective in improving the balance functions, balance confidence, and activities of daily living, neither of them were more preferable than the other for the treatment of balance in patients with chronic stroke. PMID:25995576

  4. Wii Fit balance training or progressive balance training in patients with chronic stroke: a randomised controlled trial.

    Science.gov (United States)

    Yatar, Gozde Iyigun; Yildirim, Sibel Aksu

    2015-04-01

    [Purpose] The aim of this study was to compare the effects of Wii Fit balance training (WBT) and progressive balance training (PBT) approaches on balance functions, balance confidence, and activities of daily living in chronic stroke patients. [Subjects] A total of 30 patients were randomized into the WBT (n=15) and PBT (n=15) groups. [Methods] All of the subjects received exercise training based on a neurodevelopemental approach in addition to either Wii Fit or progressive balance training for total of 1 hour a day, 3 days per week for 4 weeks. Primary measurements were static balance function measured with a Wii Balance Board and dynamic balance function assessed with the Berg Balance Scale, Timed Up and Go test, Dynamic Gait Index, and Functional Reach Test. Secondary measures were balance confidence assessed with the Activities-specific Balance Confidence scale and activities of daily living evaluated with the Frenchay Activity Index. [Results] There was not remarkable difference between the two treatments in dynamic balance functions, balance confidence, and activities of daily living. [Conclusion] Although both of the approaches were found to be effective in improving the balance functions, balance confidence, and activities of daily living, neither of them were more preferable than the other for the treatment of balance in patients with chronic stroke.

  5. ERK5 signaling gets XIAPed: a role for ubiquitin in the disassembly of a MAPK cascade

    Science.gov (United States)

    Klein, Aileen M; Cobb, Melanie H

    2014-01-01

    Mitogen-activated protein kinase (MAPK) cascades are tightly controlled through a series of well-characterized phospho-regulatory events. In this issue, Takeda et al (2014) identify the inhibitor of apoptosis protein, XIAP, as a key regulator of ERK5 activation via uncoupling of upstream kinase activity by non-degradative ubiquitination. PMID:25012518

  6. Validation of the Italian Version of the Dizziness Handicap Inventory, the Situational Vertigo Questionnaire, and the Activity-Specific Balance Confidence Scale for Peripheral and Central Vestibular Symptoms

    Directory of Open Access Journals (Sweden)

    Silvia Colnaghi

    2017-10-01

    Full Text Available Neurophysiological measurements of the vestibular function for diagnosis and follow-up evaluations provide an objective assessment, which, unfortunately, does not necessarily correlate with the patients’ self-feeling. The literature provides many questionnaires to assess the outcome of rehabilitation programs for disequilibrium, but only for the Dizziness Handicap Inventory (DHI is an Italian translation available, validated on a small group of patients suffering from a peripheral acute vertigo. We translated and validated the reliability and validity of the DHI, the Situational Vertigo Questionnaire (SVQ, and the Activities-Specific Balance Confidence Scale (ABC in 316 Italian patients complaining of dizziness due either to a peripheral or to a central vestibular deficit, or in whom vestibular signs were undetectable by means of instrumental testing or clinical evaluation. Cronbach’s coefficient alpha, the homogeneity index, and test–retest reproducibility, confirmed reliability of the Italian version of the three questionnaires. Validity was confirmed by correlation test between questionnaire scores. Correlations with clinical variables suggested that they can be used as a complementary tool for the assessment of vestibular symptoms. In conclusion, the Italian versions of DHI, SVQ, and ABC are reliable and valid questionnaires for assessing the impact of dizziness on the quality of life of Italian patients with peripheral or central vestibular deficit.

  7. Lesson "Balance in Nature

    Science.gov (United States)

    Chapanova, V.

    2012-04-01

    Lesson "Balance in Nature" This simulation game-lesson (Balance in Nature) gives an opportunity for the students to show creativity, work independently, and to create models and ideas. It creates future-oriented thought connected to their experience, allowing them to propose solutions for global problems and personal responsibility for their activities. The class is divided in two teams. Each team chooses questions. 1. Question: Pollution in the environment. 2. Question: Care for nature and climate. The teams work on the chosen tasks. They make drafts, notes and formulate their solutions on small pieces of paper, explaining the impact on nature and society. They express their points of view using many different opinions. This generates alternative thoughts and results in creative solutions. With the new knowledge and positive behaviour defined, everybody realizes that they can do something positive towards nature and climate problems and the importance of individuals for solving global problems is evident. Our main goal is to recover the ecological balance, and everybody explains his or her own well-grounded opinions. In this work process the students obtain knowledge, skills and more responsible behaviour. This process, based on his or her own experience, dialogue and teamwork, helps the participant's self-development. Making the model "human↔ nature" expresses how human activities impact the natural Earth and how these impacts in turn affect society. Taking personal responsibility, we can reduce global warming and help the Earth. By helping nature we help ourselves. Teacher: Veselina Boycheva-Chapanova " Saint Patriarch Evtimii" Scholl Str. "Ivan Vazov"-19 Plovdiv Bulgaria

  8. Dismantling the activated annular water tank of the Rheinsberg nuclear power plant

    International Nuclear Information System (INIS)

    Klietz, Maik; Konitzer, Arnold; Luedeke, Michael

    2010-01-01

    Acting on behalf of Energiewerke Nord GmbH Lubmin, Anlagen- und Kraftwerksrohrleitungsbau Greifswald GmbH (AKB) planned and built a station for disassembly of the activated annular water tank (RWB) of the decommissioned Rheinsberg nuclear power plant. As part of this demolition step, the annular water tank must be conditioned and disposed of as a component of the reactor facility. This required planning, manufacturing, testing and construction on site of suitable disassembly and handling techniques and the necessary plant and equipment. The client opted for disassembly by means of a diamond cable saw for conditioning the annular water tank into segments fit for shipping, and defined the basic components for the disassembly station in a specification of deliveries and services. The disassembly station serves to divide the annular water tank by means of diamond cable saws into 2 sections in such a way that segment pieces for transport are produced. The existing activation of the annular water tank also entailed the need to plan for the shortest possible time to be spent on handling near the annular water tank, providing radiological protection to the personnel, and performing the sawing steps from a separate operating console assisted by camera surveillance. After works acceptance tests at the manufacturer's, AKB, in October 2009 and February 2010, the disassembly station was delivered to the customer at Rheinsberg KKR free from defects in June 2010. (orig.)

  9. Altering the balance between immune activation versus regulation in the skin to promote CD8+ T-cell activity within epithelial cancers

    DEFF Research Database (Denmark)

    Bridge, Jennifer A.; Overgaard, Nana Haahr; Steptoe, Raymond

    . The expression, in a mouse model (“E7”), of the HPV16 E7 gene in keratinocytes under the control of the K14 promoter, leads to a local immune suppressive environment, as evidenced by the lack of graft rejection when E7 skin grafts are placed on WT recipient mice. Furthermore, well healed (>30 days) E7 skin...... did not reject. As in the WT mice however, rejection could be induced through the coadministration of an anti-CD4 antibody. The data suggest that the removal of a CD4+, non T-reg cell, leads to CD8+ T-cell activity in the skin as evidenced by E7 skin graft destruction....... grafts are not rejected when mice are immunised with E7 peptide in combination with Quil A- or CASAC-based adjuvants. This is despite a substantial increase in E7 peptide/H-2Db pentamer staining in the blood, and marked killing of E7-peptide expressing TC-1 cells when injected i.v., confirming that CD8 T...

  10. Occurrence and fate of pharmaceutically active compounds in the largest municipal wastewater treatment plant in Southwest China: mass balance analysis and consumption back-calculated model.

    Science.gov (United States)

    Yan, Qing; Gao, Xu; Huang, Lei; Gan, Xiu-Mei; Zhang, Yi-Xin; Chen, You-Peng; Peng, Xu-Ya; Guo, Jin-Song

    2014-03-01

    The occurrence and fate of twenty-one pharmaceutically active compounds (PhACs) were investigated in different steps of the largest wastewater treatment plant (WWTP) in Southwest China. Concentrations of these PhACs were determined in both wastewater and sludge phases by a high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Results showed that 21 target PhACs were present in wastewater and 18 in sludge. The calculated total mass load of PhACs per capita to the influent, the receiving water and sludge were 4.95mgd(-1)person(-1), 889.94μgd(-1)person(-1) and 78.57μgd(-1)person(-1), respectively. The overall removal efficiency of the individual PhACs ranged from "negative removal" to almost complete removal. Mass balance analysis revealed that biodegradation is believed to be the predominant removal mechanism, and sorption onto sludge was a relevant removal pathway for quinolone antibiotics, azithromycin and simvastatin, accounting for 9.35-26.96% of the initial loadings. However, the sorption of the other selected PhACs was negligible. The overall pharmaceutical consumption in Chongqing, China, was back-calculated based on influent concentration by considering the pharmacokinetics of PhACs in humans. The back-estimated usage was in good agreement with usage of ofloxacin (agreement ratio: 72.5%). However, the back-estimated usage of PhACs requires further verification. Generally, the average influent mass loads and back-calculated annual per capita consumption of the selected antibiotics were comparable to or higher than those reported in developed countries, while the case of other target PhACs was opposite. Copyright © 2013 Elsevier Ltd. All rights reserved.

  11. Balanced Scorecard voor inkoop

    NARCIS (Netherlands)

    van der Honing, R.; Schotanus, Fredo

    2003-01-01

    Een Balanced Scorecard kan ontwikkeld worden voor de hele organisatie, maar ook voor onderdelen daarvan. In dit artikel wordt ingegaan op de ontwikkeling van een Balanced Scorecard voor de inkoopafdeling

  12. The Balanced Company

    DEFF Research Database (Denmark)

    through control or trust. Human resource specialists need to make balanced decisions about how to design tasks and jobs in order to make them attractive as well as motivating. Marketers need to make balanced decisions about how to market products in the light of what is now important in consumers...... in their environments. Communication specialists need to make balanced decisions which take the different value systems and assumptions of stakeholders into consideration. Change specialists need to balance the need for continuity and change. Managers need to make balanced decisions about whether to achieve goals...... the creation and recreation of balanced relationships. Chapters in The Balanced Company ask and provide answers to questions about corporately responsible and ethically driven balanced decision making, such as: • How can a company and its stakeholders identify what should be taken into consideration - What...

  13. Danish Balance of Payments Support

    DEFF Research Database (Denmark)

    Tarp, Finn; Kragh, Mads Váczy

    This study is an analysis of Danish Balance for Payments Support (BOP) covering the period 1988-94. This aid instrument has not so far been used as an active tool to further Danish policy conditionalities vis-à-vis the reform process in developing countries. On the contrary, BOP has mainly been...

  14. Rough order of magnitude cost estimate for immobilization of 50 MT of plutonium sharing existing facilities at Hanford with pit disassembly and conversion facility: alternative 11

    International Nuclear Information System (INIS)

    DiSabatino, A.

    1998-01-01

    The purpose of this Cost Estimate Report is to identify preliminary capital and operating costs for a facility to immobilize 50 metric tons (nominal) of plutonium as a ceramic in an existing facility at Hanford, the Fuels and Materials Examination Facility (FMEF). The Pit Disassembly and Conversion Facility (PDCF), which is being costed in a separate report by LANL, will also be located in the FMEF in this co-location option

  15. Chance for balance: Chance for balance

    OpenAIRE

    Sævild, Katariina; Skov Sørensen, Katrine; Kildahl Lauritsen, Louise; Fuglsang, Sofie Olivia; Arnbjerg, Stine Høegh

    2015-01-01

    This project investigates how (im) balance between family and career influences Danish women's desire to have children. In order to answer this question, we have chosen to use qualitative method and our analysis is based on two semi-structured research interviews with two chosen women. Thus these women’s definition of balance and their view on children define the project. We have chosen to use of work-life balance theories, Thomas Hoejrup’s lifeform-analysis and Anthony Giddens’ theories of s...

  16. TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER-Golgi intermediate compartments.

    Science.gov (United States)

    Hanna, Michael G; Block, Samuel; Frankel, E B; Hou, Feng; Johnson, Adam; Yuan, Lin; Knight, Gavin; Moresco, James J; Yates, John R; Ashton, Randolph; Schekman, Randy; Tong, Yufeng; Audhya, Anjon

    2017-09-12

    The conserved coat protein complex II (COPII) mediates the initial steps of secretory protein trafficking by assembling onto subdomains of the endoplasmic reticulum (ER) in two layers to generate cargo-laden transport carriers that ultimately fuse with an adjacent ER-Golgi intermediate compartment (ERGIC). Here, we demonstrate that Trk-fused gene (TFG) binds directly to the inner layer of the COPII coat. Specifically, the TFG C terminus interacts with Sec23 through a shared interface with the outer COPII coat and the cargo receptor Tango1/cTAGE5. Our findings indicate that TFG binding to Sec23 outcompetes these other associations in a concentration-dependent manner and ultimately promotes outer coat dissociation. Additionally, we demonstrate that TFG tethers vesicles harboring the inner COPII coat, which contributes to their clustering between the ER and ERGIC in cells. Together, our studies define a mechanism by which COPII transport carriers are retained locally at the ER/ERGIC interface after outer coat disassembly, which is a prerequisite for fusion with ERGIC membranes.

  17. Studies and research concerning BNFP design and construction of a spent-fuel disassembly/encapsulation system

    International Nuclear Information System (INIS)

    Dabolt, R.J.

    1981-04-01

    Commercial light water power reactor operation in the United States is developing a cumbersome inventory of spent fuel. Systems for interim storage and handling of this fuel are being developed by the Federal Government and industry. Disassembly and canning of the spent fuel elements is one of these systems. It has the potential to double the storage capacity of a prereprocessing storage facility or to triple the capacity of conventional shipping casks. Prototype equipment and controls required to perform this operation in a dry environment have been primarily designed and fabricated at the Barnwell Nuclear Fuel Plant (BNFP). Ridihalgh, Eggers, and Associates have provided design support and fabrication of the control system. This system is capable of extracting and canning the fuel pins and compacting the nonfuel-bearing components of spent fuel assemblies at processing rates of 10 to 12 assemblies per day. The process also provides the potential for enhanced inspection and assay of spent fuel by reducing the interference encountered from the high gamma fields of the nonfuel bearing hardware

  18. Wood cell-wall structure requires local 2D-microtubule disassembly by a novel plasma membrane-anchored protein.

    Science.gov (United States)

    Oda, Yoshihisa; Iida, Yuki; Kondo, Yuki; Fukuda, Hiroo

    2010-07-13

    Plant cells have evolved cortical microtubules, in a two-dimensional space beneath the plasma membrane, that regulate patterning of cellulose deposition. Although recent studies have revealed that several microtubule-associated proteins facilitate self-organization of transverse cortical microtubules, it is still unknown how diverse patterns of cortical microtubules are organized in different xylem cells, which are the major components of wood. Using our newly established in vitro xylem cell differentiation system, we found that a novel microtubule end-tracking protein, microtubule depletion domain 1 (MIDD1), was anchored to distinct plasma membrane domains and promoted local microtubule disassembly, resulting in pits on xylem cell walls. The introduction of RNA interference for MIDD1 resulted in the failure of local microtubule depletion and the formation of secondary walls without pits. Conversely, the overexpression of MIDD1 reduced microtubule density. MIDD1 has two coiled-coil domains for the binding to microtubules and for the anchorage to plasma membrane domains, respectively. Combination of the two coils caused end tracking of microtubules during shrinkage and suppressed their rescue events. Our results indicate that MIDD1 integrates spatial information in the plasma membrane with cortical microtubule dynamics for determining xylem cell wall pattern. Copyright 2010 Elsevier Ltd. All rights reserved.

  19. Get the Balance Right.

    Science.gov (United States)

    Haddock, Rebecca Jaurigue

    Today work goes on 24 hours a day, 7 days a week, and is about acceleration and access. Workers need balance more than ever. In fact, recent college graduates value work/life balance as their key factor in selecting employers. This paper, written for career counselors, defines balance as encompassing emotional, spiritual, physical, and…

  20. Cesium removal from the fuel storage water at the Savannah River Site R-Building Disassembly Basin using 3M Empore reg-sign-membrane filter technology

    International Nuclear Information System (INIS)

    Oji, L.N.; Thompson, M.C.; Peterson, K.; May, C.; Kafka, T.M.

    1998-01-01

    This report describes results from a seven-day demonstration of the use of 3M Empore membrane filter loaded with ion exchange material (potassium cobalt hexacynoferrate (CoHex)) for cesium uptake from the R-Disassembly Basin at the Savannah River Site. The goal of the demonstration was to evaluate the ability of the Process Absorber Development unit (PADU), a water pre-filtration /CoHex configuration on a skid, to remove cesium from R-Disassembly Basin at a linear processing flow rate of 22.7 liters per minute (1,195.8 liters/minute/m 2 or 29.35 gallons/minute/ft 2 ). Over 210,000 liters (> 55,500 gallons) of R-Disassembly Basin water was processed through the PADU without a cesium breakthrough, that is, the effluent after treatment with CoHex, contained less than detectable amounts of radioactive cesium. Some of the observed advantages of the Empore membrane filter technology over conventional packed column ion exchange systems includes rapid flow rates without channeling effects, low volume secondary waste and fast extraction or rapid kinetics per unit of flow

  1. FaCT phase-I evaluation on the advanced aqueous reprocessing process (2). Development of mechanical disassembly and short stroke shearing systems for FBR fuel reprocessing

    International Nuclear Information System (INIS)

    Takeuchi, Masayuki; Kitagaki, Toru; Higuchi, Hidetoshi; Fukushima, Mineo; Washiya, Tadahiro; Kobayashi, Tsuguyuki

    2011-01-01

    JAEA promotes a development of an advanced head-end process in FaCT project. We selected mechanical cutting method for disassembly process and short stroke method for shearing process. In the FaCT phase-I, the criteria was set for decision about the innovative technology and some fundamental performances of the innovative technology such as precision, speed, durability, operation performance and system concept were discussed by the engineering test and design work. We designed and fabricated an engineering-scale test device for mechanical disassembly and short stroke shearing and have carried out the engineering tests using simulated fuel assemblies. As a part of the engineering test results, the effects of cutting conditions on the durability of cutting tool and cutting stability were discussed. Also, the reduction of magazine width is effective to improve the precision of sheared pin length, and the bundle of simulated fuel pins were successfully sheared to 10 ± 5mm, which is a target for the sheared pin length. The criteria for the mechanical disassembly technology and the short stroke shearing technology were satisfied, so we judged that the development of innovative technologies has worth going on for the next phase in the FaCT project. (author)

  2. Dismantling the activated annular water tank of the Rheinsberg nuclear power plant; Zerlegung des aktivierten Ringwasserbehaelters des Kernkraftwerks Rheinsberg

    Energy Technology Data Exchange (ETDEWEB)

    Klietz, Maik; Konitzer, Arnold; Luedeke, Michael [Anlagen- und Kraftwerksrohrleitungsbau GmbH, Greifswald (Germany)

    2010-10-15

    Acting on behalf of Energiewerke Nord GmbH Lubmin, Anlagen- und Kraftwerksrohrleitungsbau Greifswald GmbH (AKB) planned and built a station for disassembly of the activated annular water tank (RWB) of the decommissioned Rheinsberg nuclear power plant. As part of this demolition step, the annular water tank must be conditioned and disposed of as a component of the reactor facility. This required planning, manufacturing, testing and construction on site of suitable disassembly and handling techniques and the necessary plant and equipment. The client opted for disassembly by means of a diamond cable saw for conditioning the annular water tank into segments fit for shipping, and defined the basic components for the disassembly station in a specification of deliveries and services. The disassembly station serves to divide the annular water tank by means of diamond cable saws into 2 sections in such a way that segment pieces for transport are produced. The existing activation of the annular water tank also entailed the need to plan for the shortest possible time to be spent on handling near the annular water tank, providing radiological protection to the personnel, and performing the sawing steps from a separate operating console assisted by camera surveillance. After works acceptance tests at the manufacturer's, AKB, in October 2009 and February 2010, the disassembly station was delivered to the customer at Rheinsberg KKR free from defects in June 2010. (orig.)

  3. DYMAC digital electronic balance

    International Nuclear Information System (INIS)

    Stephens, M.M.

    1980-06-01

    The Dynamic Materials Accountability (DYMAC) System at LASL integrates nondestructive assay (NDA) instruments with interactive data-processing equipment to provide near-real-time accountability of the nuclear material in the LASL Plutonium Processing Facility. The most widely used NDA instrument in the system is the DYMAC digital electronic balance. The DYMAC balance is a commercial instrument that has been modified at LASL for weighing material in gloveboxes and for transmitting the weight data directly to a central computer. This manual describes the balance components, details the LASL modifications, reviews a DYMAC measurement control program that monitors balance performance, and provides instructions for balance operation and maintenance

  4. Lithuania’s Balancing Act

    Directory of Open Access Journals (Sweden)

    Šlekys Deividas

    2017-12-01

    Full Text Available Since regaining independence in 1990 and creating its regular armed forces, Lithuania has had to do a balancing act. It has had to balance between different approaches of state defence, military structure, collective and national defence. Due to events in Ukraine Lithuania had to reconfigure this balance. The Russian threat forced to emphasize strategy of territorial defence, which altogether required tying up forces and enlarging its numbers by bringing back conscription, substantially increased defence budget, followed by higher tempo and scale in procurement and training. However, Lithuania has managed to maintain its activity and participation in international military operations and political initiatives. Its recent contributions have led to an assumption that its participation in various military missions in the future will not diminish, quite the opposite. Increasing the framework of cooperation in terms of defence and security initiatives will involve Lithuania more deeply and will require further contributions.

  5. Earthworms and the soil greenhouse gas balance

    NARCIS (Netherlands)

    Lubbers, I.M.

    2014-01-01

    Earthworms play an essential part in determining the greenhouse gas (GHG) balance of soils worldwide. Their activity affects both biotic and abiotic soil properties, which in turn influence soil GHG emissions, carbon (C) sequestration and plant growth. Yet, the balance of earthworms

  6. Fast reactor fuel reprocessing plant D1206: disassembly cave window 4 replacement

    International Nuclear Information System (INIS)

    Sutherland, H.G.; Beckitt, S.; Potts, A.B.

    1996-01-01

    At UKAEA's fast reactor reprocessing plant at Dounreay, the containment glass on the zinc bromide cave viewing window tank failed after 13 years active use. External shielding was fitted and the window tank subsequently drained to make it safe. Fuel cropping operations carried out behind the window were resited to enable cave work to continue whilst a project team made arrangements and plans to replace the damaged window. Because of the complexity of the task and high (alpha, beta, gamma and neutron) radiation levels in excess of 500 Sv/hr a rehearsal facility was built to develop the remote handling techniques to be employed in the task. (UK)

  7. Postural balance, its sensory-motor correlates and self-reported functional ability in 75-year-old men and women: A cross-national comparative study

    DEFF Research Database (Denmark)

    Schroll, Marianne; Pertti, Era; Avlund, Kirsten

    1999-01-01

    Social medicine, postural balance, functional ability, activities of daily living, physical activity, ageing......Social medicine, postural balance, functional ability, activities of daily living, physical activity, ageing...

  8. Occupational balance in health professionals in Sweden.

    Science.gov (United States)

    Wagman, Petra; Lindmark, Ulrika; Rolander, Bo; Wåhlin, Charlotte; Håkansson, Carita

    2017-01-01

    Health care employees are often women, a group that has high degrees of sick leave and perhaps problems attaining occupational balance. However, people think differently about their everyday activities and it is therefore important to take their perceptions into account but occupational balance has not yet been measured in health professionals. The aim was to describe occupational balance in three different samples of health professionals in Sweden. A further aim was to investigate whether occupational therapists (OTs) rate their occupational balance differently from other health professionals. Four hundred and eighty-two health professionals, employees in public dentistry, mental health care and OTs, aged 21-70 years participated. The participants' occupational balance was measured using the occupational balance questionnaire (OBQ). The ratings of occupational balance were similar to earlier studies and did not differ significantly between the samples. The OTs' occupational balance was also similar to that of the other health professionals. The similarities in occupational balance indicate the same difficulties in attaining it. The result highlights the possibility that working people face similar difficulties in achieving occupational balance. Further research is warranted about how to attain it.

  9. Hemorheological changes, the state of microcirculation, and blood acid-base balance in rats under conditions of a 30-day limiting of the motor activity

    Science.gov (United States)

    Shtykhno, Y. M.; Udovichenko, V. I.

    1980-01-01

    Changes were expressed in reduction in number of true capillaries, the appearance of nonfunctioning empty vessels and in the opening of the arteriolo-venular shunts. Changes in the acid-base balance in the direction of reduction of buffer blood content were also noted.

  10. Expert System analysis of non-fuel assembly hardware and spent fuel disassembly hardware: Its generation and recommended disposal

    International Nuclear Information System (INIS)

    Williamson, D.A.

    1991-01-01

    Almost all of the effort being expended on radioactive waste disposal in the United States is being focused on the disposal of spent Nuclear Fuel, with little consideration for other areas that will have to be disposed of in the same facilities. one area of radioactive waste that has not been addressed adequately because it is considered a secondary part of the waste issue is the disposal of the various Non-Fuel Bearing Components of the reactor core. These hardware components fall somewhat arbitrarily into two categories: Non-Fuel Assembly (NFA) hardware and Spent Fuel Disassembly (SFD) hardware. This work provides a detailed examination of the generation and disposal of NFA hardware and SFD hardware by the nuclear utilities of the United States as it relates to the Civilian Radioactive Waste Management Program. All available sources of data on NFA and SFD hardware are analyzed with particular emphasis given to the Characteristics Data Base developed by Oak Ridge National Laboratory and the characterization work performed by Pacific Northwest Laboratories and Rochester Gas ampersand Electric. An Expert System developed as a portion of this work is used to assist in the prediction of quantities of NFA hardware and SFD hardware that will be generated by the United States' utilities. Finally, the hardware waste management practices of the United Kingdom, France, Germany, Sweden, and Japan are studied for possible application to the disposal of domestic hardware wastes. As a result of this work, a general classification scheme for NFA and SFD hardware was developed. Only NFA and SFD hardware constructed of zircaloy and experiencing a burnup of less than 70,000 MWD/MTIHM and PWR control rods constructed of stainless steel are considered Low-Level Waste. All other hardware is classified as Greater-ThanClass-C waste

  11. Effects of local fatigue on myoelectrical activity of erector spine muscles and the center for pressure displacement of the feet during balance recovery following postural perturbation in kyphotic subjects

    Directory of Open Access Journals (Sweden)

    Rooholah Rezaee

    2014-07-01

    Full Text Available Background: kyphosis deformity affects postural control. Muscular fatigue is one of the factors that can impair the mechanism of body balance. The aim of this study was to determine the effects of local fatigue on the myoelectrical activity of erector spine muscles and the center for pressure displacement of the feet during balance recovery following postural perturbation in kyphotic subjects. Methods: In this quasi-experimental study, 12 male students with>40 degrees thoracic kyphosis and 12 controls were selected to participate in the study. A flexible ruler was used to measure thoracic kyphosis. For postural control assessment, each subject underwent unexpected, forward-backward perturbations while standing on a foot scan mounted on a movable plate triggered by a weight equivalent to 10% of the subjects’ body weight. Experimental procedure was measured before (3 trails and after (3 trials the fatigue protocol. The myoelectric activity of the erector spine and multi fidus was compared in the groups using repeated measures of ANOVA and independent t-test (P<0.05. Results: There was no significant difference in the foot center of pressure displacement in both groups after muscular fatigue. After fatigue, there was an increase in the activity of longissimus thoracis (P=0.001 and iliocostalis thoracis (P= 0.001 in control group, while no significant difference was reported for the muscular activity of multifidus (p=0.084. The activity of langisimus thoracis was significantly increased (P=0.028 in kyphtic group after fatigue. Conclusion: erector spine muscles fatigue could not significantly affect the postural control in both groups, but the electrical activity of erector spine muscles during balance recovery following postural perturbation in kyphotic subjects was different than the controls.

  12. Balanced microwave filters

    CERN Document Server

    Hong, Jiasheng; Medina, Francisco; Martiacuten, Ferran

    2018-01-01

    This book presents and discusses strategies for the design and implementation of common-mode suppressed balanced microwave filters, including, narrowband, wideband, and ultra-wideband filters This book examines differential-mode, or balanced, microwave filters by discussing several implementations of practical realizations of these passive components. Topics covered include selective mode suppression, designs based on distributed and semi-lumped approaches, multilayer technologies, defect ground structures, coupled resonators, metamaterials, interference techniques, and substrate integrated waveguides, among others. Divided into five parts, Balanced Microwave Filters begins with an introduction that presents the fundamentals of balanced lines, circuits, and networks. Part 2 covers balanced transmission lines with common-mode noise suppression, including several types of common-mode filters and the application of such filters to enhance common-mode suppression in balanced bandpass filters. Next, Part 3 exa...

  13. Balancing Trust and Control

    DEFF Research Database (Denmark)

    Jagd, Søren

    2010-01-01

    of balancing trust and control becomes an issue that deserve ongoing attention. This paper adds to the discussion on the relation between trust and control by showing that the process perspective reframes the problem of balancing trust and control. More generally, by demonstrating the importance of the process......The purpose of this paper is to show that conceptualizing trust and control as interactively related processes, as opposed to more static conceptualizations of the two concepts and the relations between them, adds importantly towards understanding the challenges involved in balancing of trust...... on trust and control made the problem of finding a balance between trust and control a once and for all decision the process perspective introduced here implies that balancing trust and control is an ongoing process of balancing and rebalancing. The implication for management is that the problem...

  14. Balance and flexibility.

    Science.gov (United States)

    2003-12-01

    The 'work-life balance' and flexible working are currently key buzz terms in the NHS. Those looking for more information on these topics should visit Flexibility at www.flexibility.co.uk for a host of resources designed to support new ways of working, including information on flexible workers and flexible rostering, the legal balancing act for work-life balance and home working.

  15. Balance of power

    OpenAIRE

    Lucas, James Raymond

    2012-01-01

    This Paper argues that the efficiency distribution of players in a game determines how aggressively these players interact. We formalize the idea of balance of power: players fight very inefficient players but play softly versus equally (or more) efficient players. This theory of conduct predicts that entry by new firms leads to a less aggressive outcome if it creates a balance of power. A balance of power is created if more players get technologies that are close to the most efficient techno...

  16. Work-Life Balance

    OpenAIRE

    Kvasničková, Katarína

    2011-01-01

    The subject of this thesis is Work-Life Balance - the reconciliation of professional and personal lives. The primary objective of this work is to analyze employee satisfaction in achieving a balance between the professional and personal life and to develop recommendations for employer on that basis. The theoretical portion of this work defines the issues surrounding Work-Life Balance and tools that employees can use to harmonize the two with an analysis of applications in the Czech Republic a...

  17. Specific balance training included in an endurance-resistance exercise program improves postural balance in elderly patients undergoing haemodialysis.

    Science.gov (United States)

    Frih, Bechir; Mkacher, Wajdi; Jaafar, Hamdi; Frih, Ameur; Ben Salah, Zohra; El May, Mezry; Hammami, Mohamed

    2018-04-01

    The purpose of this study was to evaluate the effects of 6 months of specific balance training included in endurance-resistance program on postural balance in haemodialysis (HD) patients. Forty-nine male patients undergoing HD were randomly assigned to an intervention group (balance training included in an endurance-resistance training, n = 26) or a control group (resistance-endurance training only, n = 23). Postural control was assessed using six clinical tests; Timed Up and Go test, Tinetti Mobility Test, Berg Balance Scale, Unipodal Stance test, Mini-Balance Evaluation Systems Test and Activities Balance Confidence scale. All balance measures increased significantly after the period of rehabilitation training in the intervention group. Only the Timed Up and Go, Berg Balance Scale, Mini-Balance Evaluation Systems Test and Activities Balance Confidence scores were improved in the control group. The ranges of change in these tests were greater in the balance training group. In HD patients, specific balance training included in a usual endurance-resistance training program improves static and dynamic balance better than endurance-resistance training only. Implications for rehabilitation Rehabilitation using exercise in haemodialysis patients improved global mobility and functional abilities. Specific balance training included in usual endurance resistance training program could lead to improved static and dynamic balance.

  18. Paul Collier : Balancing beams

    CERN Multimedia

    2009-01-01

    As former head of AB Operations, Paul Collier and his group were in the ‘cockpit’ for the LHC’s maiden voyage - piloting the first beam around the ring. But now, as Head of the Beams Department, he will need his feet firmly on the ground in order to balance all the beam activities at CERN. "As Department Head, I’ll have less direct contact with the machines," Collier says with a hint of regret. "I’ll still obviously be very involved, but they won’t actually let me loose in front of the keyboard anymore!" As the new Head of the BE Department, Collier will be in charge of nearly 400 people, and will oversee all the beam activities, including the preparations for the longest period of beam operation in the history of CERN. In the new organization, the BE, TE and EN Departments have been grouped together in the Accelerator and Technology Sector. "‘Partnership’ is a key word for the three departments," says Collier. "The n...

  19. Activation of PPARs α, β/δ, and γ Impairs TGF-β1-Induced Collagens' Production and Modulates the TIMP-1/MMPs Balance in Three-Dimensional Cultured Chondrocytes

    Directory of Open Access Journals (Sweden)

    Paul-Emile Poleni

    2010-01-01

    Full Text Available Background and Purpose. We investigated the potency of Peroxisome Proliferators-Activated Receptors (PPARs α, β/δ, and γ agonists to modulate Transforming Growth Factor-β1 (TGF-β1- induced collagen production or changes in Tissue Inhibitor of Matrix Metalloproteinase- (TIMP- 1/Matrix Metalloproteinase (MMP balance in rat chondrocytes embedded in alginate beads. Experimental Approach. Collagen production was evaluated by quantitative Sirius red staining, while TIMP-1 protein levels and global MMP (-1, -2, -3, -7, and -9 or specific MMP-13 activities were measured by ELISA and fluorigenic assays in culture media, respectively. Levels of mRNA for type II collagen, TIMP-1, and MMP-3 & 13 were quantified by real-time PCR. Key Results. TGF-β1 increased collagen deposition and type II collagen mRNA levels, while inducing TIMP-1 mRNA and protein expression. In contrast, it decreased global MMP or specific MMP-13 activities, while decreasing MMP-3 or MMP-13 mRNA levels. PPAR agonists reduced most of the effects of TGF-β1 on changes in collagen metabolism and TIMP-1/MMP balance in rat in a PPAR-dependent manner, excepted for Wy14643 on MMP activities. Conclusions and Implications. PPAR agonists reduce TGF-β1-modulated ECM turnover and inhibit chondrocyte activities crucial for collagen biosynthesis, and display a different inhibitory profile depending on selectivity for PPAR isotypes.

  20. Identifying Balance in a Balanced Scorecard System

    Science.gov (United States)

    Aravamudhan, Suhanya; Kamalanabhan, T. J.

    2007-01-01

    In recent years, strategic management concepts seem to be gaining greater attention from the academicians and the practitioner's alike. Balanced Scorecard (BSC) concept is one such management concepts that has spread in worldwide business and consulting communities. The BSC translates mission and vision statements into a comprehensive set of…

  1. Balance og stofskifte

    DEFF Research Database (Denmark)

    2011-01-01

    Udstilling på Medicinsk Museion. Baseret på bevilling fra Assens Fond. Se mere på http://www.museion.ku.dk/whats-on/exhibitions/balance-and-metabolism/......Udstilling på Medicinsk Museion. Baseret på bevilling fra Assens Fond. Se mere på http://www.museion.ku.dk/whats-on/exhibitions/balance-and-metabolism/...

  2. Conclusion: The balanced company

    DEFF Research Database (Denmark)

    Scheuer, John Damm; Jensen, Inger

    2013-01-01

    This concluding chapter brings together the various research findings of the book "The balanced company - organizing for the 21st Century" and develops a general overview of their implications for our understanding of the balancing processes unfolding in companies and organizations....

  3. A Smartphone Inertial Balance

    Science.gov (United States)

    Barrera-Garrido, Azael

    2017-01-01

    In order to measure the mass of an object in the absence of gravity, one useful tool for many decades has been the inertial balance. One of the simplest forms of inertial balance is made by two mass holders or pans joined together with two stiff metal plates, which act as springs.

  4. Mobility Balance Sheet 2009

    International Nuclear Information System (INIS)

    Jorritsma, P.; Derriks, H.; Francke, J.; Gordijn, H.; Groot, W.; Harms, L.; Van der Loop, H.; Peer, S.; Savelberg, F.; Wouters, P.

    2009-06-01

    The Mobility Balance Sheet provides an overview of the state of the art of mobility in the Netherlands. In addition to describing the development of mobility this report also provides explanations for the growth of passenger and freight transport. Moreover, the Mobility Balance Sheet also focuses on a topical theme: the effects of economic crises on mobility. [nl

  5. Balance Disorders (For Parents)

    Science.gov (United States)

    ... This nerve sends signals to the brain that control hearing (auditory function) and help with balance (vestibular function). But the ears aren't the ... symptoms aren't necessarily a sign of a balance problem — or any other ... stumble and fall sometimes, especially toddlers just learning to walk and ...

  6. Trust-distrust Balance

    DEFF Research Database (Denmark)

    Jukka, Minna; Blomqvist, Kirsimarja; Li, Peter Ping

    2017-01-01

    notion of "guanxi" as personal ties. In contrast, the Finnish managers' view of trustworthiness was more associated with depersonalized organizational attributes. They emphasized the dimension of integrity, especially promise-keeping. In addition, tentative signs of trust ambivalence, as a balance...... opposites constitute a duality to be managed from the perspective of yin-yang balancing....

  7. Lust-Balance

    NARCIS (Netherlands)

    Wouters, Cas

    2007-01-01

    The concept of the lust-balance refers to the social organization and accompanying social codes (ideals and practices) regarding the relationship between the longing for sexual gratification and the longing for enduring relational intimacy. It thus draws attention to the balance between emotive

  8. Balancing for nonlinear systems

    NARCIS (Netherlands)

    Scherpen, J.M.A.

    1993-01-01

    We present a method of balancing for nonlinear systems which is an extension of balancing for linear systems in the sense that it is based on the input and output energy of a system. It is a local result, but gives 'broader' results than we obtain by just linearizing the system. Furthermore, the

  9. Chemical Equation Balancing.

    Science.gov (United States)

    Blakley, G. R.

    1982-01-01

    Reviews mathematical techniques for solving systems of homogeneous linear equations and demonstrates that the algebraic method of balancing chemical equations is a matter of solving a system of homogeneous linear equations. FORTRAN programs using this matrix method to chemical equation balancing are available from the author. (JN)

  10. Energy balance and stability

    International Nuclear Information System (INIS)

    Hammer, R.

    1982-01-01

    The energy balance of the outer atmospheres of solarlike stars is discussed. The energy balance of open coronal regions is considered, discussing the construction and characteristics of models of such regions in some detail. In particular, the temperature as a function of height is considered, as are the damping length dependence of the global energy balance in the region between the base of the transition region and the critical point, and the effects of changing the amount of coronal heating, the stellar mass, and the stellar radius. Models of coronal loops are more briefly discussed. The chromosphere is then included in the discussion of the energy balance, and the connection between global energy balance and global thermal stability is addressed. The observed positive correlations between the chromospheric and coronal energy losses and the pressure of the transition region is qualitatively explained

  11. Balancing Trust and Control

    DEFF Research Database (Denmark)

    Jagd, Søren

    This paper focuses on the leadership challenge of balancing trust and control. The relation between trust and control has for a long time been a puzzling issue for management researchers. In the paper I first show that there has been a dramatic change in the way the relation between trust...... and control has been conceptualized in trust research. While the relation between trust and control earlier was conceptualized as a more or less stable balance between trust and control, more recent research conceptualizes the relation between trust and control more as a dynamical process that involves...... an ongoing process of balancing the relation between trust and control. Second, taking the departure in the recent conceptualization of the balance between trust and control as an interactive process I discuss the challenges for management in handling this more subtle balancing of trust and control...

  12. Authorized Limits for the Release of a 25 Ton Locomotive, Serial Number 21547, at the Area 25 Engine Maintenance, Assembly, and Disassembly Facility, Nevada Test Site, Nevada

    International Nuclear Information System (INIS)

    Gwin, Jeremy; Frenette, Douglas

    2010-01-01

    This document contains process knowledge and radiological data and analysis to support approval for release of the 25-ton locomotive, Serial Number 21547, at the Area 25 Engine Maintenance, Assembly, and Disassembly (EMAD) Facility, located on the Nevada Test Site (NTS). The 25-ton locomotive is a small, one-of-a-kind locomotive used to move railcars in support of the Nuclear Engine for Rocket Vehicle Application project. This locomotive was identified as having significant historical value by the Nevada State Railroad Museum in Boulder City, Nevada, where it will be used as a display piece. A substantial effort to characterize the radiological conditions of the locomotive was undertaken by the NTS Management and Operations Contractor, National Security Technologies, LLC (NSTec). During this characterization process, seven small areas on the locomotive had contamination levels that exceeded the NTS release criteria (limits consistent with U.S. Department of Energy (DOE) Order DOE O 5400.5, 'Radiation Protection of the Public and the Environment'). The decision was made to perform radiological decontamination of these known accessible impacted areas to further the release process. On February 9, 2010, NSTec personnel completed decontamination of these seven areas to within the NTS release criteria. Although all accessible areas of the locomotive had been successfully decontaminated to within NTS release criteria, it was plausible that inaccessible areas of the locomotive (i.e., those areas on the locomotive where it was not possible to perform radiological surveys) could potentially have contamination above unrestricted release limits. To access the majority of these inaccessible areas, the locomotive would have to be disassembled. A complete disassembly for a full radiological survey could have permanently destroyed parts and would have ruined the historical value of the locomotive. Complete disassembly would also add an unreasonable financial burden for the

  13. Advance on the technology of assembly and disassembly of a head frame with four legs and the machine-assembled head frame

    Energy Technology Data Exchange (ETDEWEB)

    Zhou Youzong; Cao Baozhen [Ministry of Coal Industry (China). Geological Exploration Machinery Factory

    1996-12-31

    According to the meditation of assembling headframes from upper to lower instead of that from lower to upper, the authors created successfully a new type of machine for assembling and disassembling headframes as well as a type of machine-assembled headframe. The new type of headframe not only has the merits of old type of headframe with four legs, but also can keep people away from dangers of working in high space and save the workers much labour. The new technology has good effect on raising productive efficiency. 2 figs.

  14. Disassembly and reassembly of human papillomavirus virus-like particles produces more virion-like antibody reactivity

    Directory of Open Access Journals (Sweden)

    Zhao Qinjian

    2012-02-01

    Full Text Available Abstract Background Human papillomavirus (HPV vaccines based on major capsid protein L1 are licensed in over 100 countries to prevent HPV infections. The yeast-derived recombinant quadrivalent HPV L1 vaccine, GARDASIL(R, has played an important role in reducing cancer and genital warts since its introduction in 2006. The L1 proteins self-assemble into virus-like particles (VLPs. Results VLPs were subjected to post-purification disassembly and reassembly (D/R treatment during bioprocessing to improve VLP immunoreactivity and stability. The post-D/R HPV16 VLPs and their complex with H16.V5 neutralizing antibody Fab fragments were visualized by cryo electron microscopy, showing VLPs densely decorated with antibody. Along with structural improvements, post-D/R VLPs showed markedly higher antigenicity to conformational and neutralizing monoclonal antibodies (mAbs H16.V5, H16.E70 and H263.A2, whereas binding to mAbs recognizing linear epitopes (H16.J4, H16.O7, and H16.H5 was greatly reduced. Strikingly, post-D/R VLPs showed no detectable binding to H16.H5, indicating that the H16.H5 epitope is not accessible in fully assembled VLPs. An atomic homology model of the entire HPV16 VLP was generated based on previously determined high-resolution structures of bovine papillomavirus and HPV16 L1 pentameric capsomeres. Conclusions D/R treatment of HPV16 L1 VLPs produces more homogeneous VLPs with more virion-like antibody reactivity. These effects can be attributed to a combination of more complete and regular assembly of the VLPs, better folding of L1, reduced non-specific disulfide-mediated aggregation and increased stability of the VLPs. Markedly different antigenicity of HPV16 VLPs was observed upon D/R treatment with a panel of monoclonal antibodies targeting neutralization sensitive epitopes. Multiple epitope-specific assays with a panel of mAbs with different properties and epitopes are required to gain a better understanding of the immunochemical

  15. Enhancing flora balance in the gastrointestinal tract of mice by lactic acid bacteria from Chinese sourdough and enzyme activities indicative of metabolism of protein, fat, and carbohydrate by the flora.

    Science.gov (United States)

    Yang, Dong; Yu, Xiaomin; Wu, Yaoping; Chen, Xingxing; Wei, Hua; Shah, Nagendra P; Xu, Feng

    2016-10-01

    In this study, we investigated the effect of administration of 5 strains of lactic acid bacteria (LAB) isolated from traditional Chinese sourdough on the flora balance of gastrointestinal tract of mice. We specifically measured Enterococcus, Enterobacter, Bacteroides, and Lactobacillus by plate count and real-time PCR methods, and α-glucosidase, lactate dehydrogenase, esterase, and aminopeptidase activities as indicative of metabolism of sugar, fat, and protein from LAB isolated from feces of mice in vitro. The results showed that administration of Lactobacillus acidophilus LAC0201 and Lactobacillus fermentum LFE0302 lowered the uricacid index of serum. Lactobacillus acidophilus LAC0201, L. fermentum LFE0302, as well as Lactobacillus curvatus LCU0401 administration resulted in a reduction in the opportunistic pathogens (i.e., Enterococcus and Enterobacter), meanwhile, administration of L. fermentum LFE0302 and Lactobacillus sp. ULA0104 resulted in an increase in the counts of Lactobacillus. Lactobacillus fermentum LFE0302 administration increased starch digestion of intestinal flora after 4wk of feeding and also resulted in increased α-glucosidase activity in the intestinal flora after 3wk of feeding. We found a similar trend in esterase activity after administration of L. acidophilus LAC0201 for 3wk. Hence, our study suggested that LAB from Chinese sourdough might be used as potential probiotics to strengthen the flora balance in gastrointestinal tract and positively change the metabolism of nutrients through bacterial enzyme activities. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  16. Effect of therapeutic horseback riding on balance in community-dwelling older adults with balance deficits.

    Science.gov (United States)

    Homnick, Douglas N; Henning, Kim M; Swain, Charlene V; Homnick, Tamara D

    2013-07-01

    Falls are an important cause of morbidity in older adults. Equine-assisted activities including therapeutic riding (TR) benefit balance and neuromuscular control in patients with neurological disabilities but have not been systematically studied in older adults at greater risk for falls due to balance deficits. The effect of an 8-week TR program on measures of balance and quality of life in community-dwelling older adults with established balance deficits was evaluated. This was a pretest-post-test single-group trial of a TR program on measures of balance and quality of life. The study was conducted at a Professional Association of Therapeutic Horsemanship (PATH) International Premier riding center. The subjects comprised 9 adults (5 female, 4 males) with a mean age 76.4 years (range 71-83 years). This included an 8-week observation period followed by an 8-week TR program consisting of 1 hour per week of supervised horseback riding and an 8-week follow-up period. SUBJECTS received balance testing at weeks 0, 8, 16, and 24 using the Fullerton Advanced Balance Scale (FABS), and quality of life was measured at weeks 8 and 16 using the Rand SF (short form) 36 quality-of-life measure. OUTCOME MEASURES were change in the FABS and Rand SF 36. There was no significant difference in balance scores between the start and end of the observation period. There was a significant improvement in the balance score and perception of general health from the start to the end of the intervention period, and no significant difference between the end of the intervention and the end of study, suggesting that improvements may have been sustained. TR is a safe activity for older adults with mild to moderate balance deficits and leads to both improvements in balance and quality of life. Longer and larger studies to assess the benefit of equine-assisted activities on improvements in balance and reduction in fall risk are needed.

  17. Load Balancing Scientific Applications

    Energy Technology Data Exchange (ETDEWEB)

    Pearce, Olga Tkachyshyn [Texas A & M Univ., College Station, TX (United States)

    2014-12-01

    The largest supercomputers have millions of independent processors, and concurrency levels are rapidly increasing. For ideal efficiency, developers of the simulations that run on these machines must ensure that computational work is evenly balanced among processors. Assigning work evenly is challenging because many large modern parallel codes simulate behavior of physical systems that evolve over time, and their workloads change over time. Furthermore, the cost of imbalanced load increases with scale because most large-scale scientific simulations today use a Single Program Multiple Data (SPMD) parallel programming model, and an increasing number of processors will wait for the slowest one at the synchronization points. To address load imbalance, many large-scale parallel applications use dynamic load balance algorithms to redistribute work evenly. The research objective of this dissertation is to develop methods to decide when and how to load balance the application, and to balance it effectively and affordably. We measure and evaluate the computational load of the application, and develop strategies to decide when and how to correct the imbalance. Depending on the simulation, a fast, local load balance algorithm may be suitable, or a more sophisticated and expensive algorithm may be required. We developed a model for comparison of load balance algorithms for a specific state of the simulation that enables the selection of a balancing algorithm that will minimize overall runtime.

  18. Effects of circular gait training on balance, balance confidence in patients with stroke: a pilot study.

    Science.gov (United States)

    Park, Shin-Kyu; Kim, Sung-Jin; Yoon, Tak Yong; Lee, Suk-Min

    2018-05-01

    [Purpose] This study aimed to investigate the effects of circular gait training on balance and balance confidence in patients with stroke. [Subjects and Methods] Fifteen patients with stroke were randomly divided into either the circular gait training (CGT) group (n=8) or the straight gait training (SGT) group (n=7). Both groups had conventional therapy that adhered to the neurodevelopmental treatment (NDT) approach, for 30 min. In addition, the CGT group performed circular gait training, and the SGT group practiced straight gait training for 30 min. Each intervention was applied for 1 h, 5 days a week, for 2 weeks. Berg Balance Scale (BBS), Timed Up and Go (TUG) test, and Activities-specific Balance Confidence (ABC) scale were used to test balance and balance confidence. [Results] After the intervention, both groups showed significant increases in balance and balance confidence. Significant improvements in the balance of the CGT group compared with the SGT group were observed at post-assessment. [Conclusion] This study showed that circular gait training significantly improves balance in patients with stroke.

  19. Errors in potassium balance

    International Nuclear Information System (INIS)

    Forbes, G.B.; Lantigua, R.; Amatruda, J.M.; Lockwood, D.H.

    1981-01-01

    Six overweight adult subjects given a low calorie diet containing adequate amounts of nitrogen but subnormal amounts of potassium (K) were observed on the Clinical Research Center for periods of 29 to 40 days. Metabolic balance of potassium was measured together with frequent assays of total body K by 40 K counting. Metabolic K balance underestimated body K losses by 11 to 87% (average 43%): the intersubject variability is such as to preclude the use of a single correction value for unmeasured losses in K balance studies

  20. National Energy Balance - 1985

    International Nuclear Information System (INIS)

    Anon.

    1985-01-01

    The National Energy Balance - 1985 shows energy fluxes of several primary and secondary energy sources, since the production to the final consumption in the main economic sectors, since 1974 to 1984 (E.G.) [pt

  1. National Energy Balance - 1984

    International Nuclear Information System (INIS)

    Anon.

    1984-01-01

    The National Energy Balance - 1984 shows energy fluxes of several primary and secondary energy sources, since the productions to final consumption in the main economic sectors, since 1973 to 1983. (E.G.) [pt

  2. Transmission on Balance 2006

    International Nuclear Information System (INIS)

    2007-02-01

    Every year he Dutch Transmission System Operator (TSO) TenneT issues the title publication 'Transmission on Balance'. This report provides information about the main technical operating results in the past year.

  3. The Balanced Literacy Diet.

    Science.gov (United States)

    Willows, Dale

    2002-01-01

    Describes professional development program in Ontario school district to improve student reading and writing skills. Program used food-pyramid concepts to help teacher learn to provide a balanced and flexible approach to literacy instruction based on student needs. (PKP)

  4. National Energy Balance-1987

    International Nuclear Information System (INIS)

    Anon.

    1987-01-01

    The National Energy Balance - 1987 showns energy fluxes of several primary and secondary energy sources, since the production to final consumption in the main economic sectors, since 1971 to 1986. (E.G.) [pt

  5. In Balance With

    Directory of Open Access Journals (Sweden)

    Courtney Kessel

    2013-01-01

    Full Text Available 'In Balance With' (2012 is a live performance with Courtney Kessel and her daughter, Chloé, sitting at opposite ends of a seesaw. During the 30-minute performance, Kessel adds items representative of their lives to Chloé's side of the seesaw. After each group of items is added, she returns to her side to check the balance. Toys, violin, research books, food, pots, tools, and laundry are strapped on to the seesaw. The audience witnesses the struggle to create a balance between work, home, research, and play as a single mother and artist. As equilibrium is achieved, Kessel stills labors to maintain the balance until Chloé is ready to get down, thus signaling that her work can only happen when her daughter is cared for and occupied.

  6. Energy balances 2000

    International Nuclear Information System (INIS)

    Anon.

    2000-01-01

    The energy balances of the Danish Statistical Office are the designation of the goods balances, which are tabulated for each energy article in both physical entities (quantities) and in base rates (values). The balance concept is connected to the definition supply = use, which is the basis for the construction of the system. The supply is determined as the sum of two items: import and production while the total use is the sum of 138 items: export, waste and transmission loss, stock increase, input in lack of the 130 industries, and private consumption divided into 5 consumption groups. The statistical analysis is performed yearly in both quantities and values for 35 energy articles. Values are computed for base rates, profits, taxes, VAT and market prices (buyer's price), respectively. The energy balances from 1975 to 2000 are presented for comparison. (EHS)

  7. Balancing beyond the horizon?

    DEFF Research Database (Denmark)

    Kluth, Michael Friederich; Pilegaard, Jess

    2011-01-01

    The present article seeks to make sense of recent European Union (EU) naval capability changes by applying neo-realist theory to the EU as a collective actor in the global balance of power. The paper compares two different strands of neorealist theory by deducing key predictions about the expecte......-term balancing strategy aimed at bolstering the autonomy and international influence of the Union vis-a`-vis other major powers, including the USA....

  8. Greenland Ice Sheet Mass Balance

    Science.gov (United States)

    Reeh, N.

    1984-01-01

    Mass balance equation for glaciers; areal distribution and ice volumes; estimates of actual mass balance; loss by calving of icebergs; hydrological budget for Greenland; and temporal variations of Greenland mass balance are examined.

  9. Balances instruments, manufacturers, history

    CERN Document Server

    Robens, Erich; Kiefer, Susanne

    2014-01-01

    The book deals mainly with direct mass determination by means of a conventional balances. It covers the history of the balance from the beginnings in Egypt earlier than 3000 BC to recent developments. All balance types are described with emphasis on scientific balances. Methods of indirect mass determination, which are applied to very light objects like molecules and the basic particles of matter and celestial bodies, are included.  As additional guidance, today’s manufacturers are listed and the profile of important companies is reviewed. Several hundred photographs, reproductions and drawings show instruments and their uses. This book includes commercial weighing instruments for merchandise and raw materials in workshops as well as symbolic weighing in the ancient Egyptian’s ceremony of ‘Weighing of the Heart’, the Greek fate balance, the Roman  Justitia, Juno Moneta and Middle Ages scenes of the Last Judgement with Jesus or St. Michael and of modern balances. The photographs are selected from the...

  10. The effects of Nintendo Wii(TM)-based balance and upper extremity training on activities of daily living and quality of life in patients with sub-acute stroke: a randomized controlled study.

    Science.gov (United States)

    Şimşek, Tülay Tarsuslu; Çekok, Kübra

    2016-12-01

    The aim of this study was to investigate the effects of Nintendo Wii(TM)-based balance and upper extremity training on activities of daily living and quality of life in patients with subacute stroke. 42 adults with stroke (mean age (SD) = 58.04 (16.56) years and mean time since stroke (SD) = (55.2 ± 22.02 days (∼8 weeks)) were included in the study. Participants were enrolled from the rehabilitation department of a medical center (a single inpatient rehabilitation facility). Participants were randomly assigned to Nintendo Wii group (n = 20) or Bobath neurodevelopmental treatment (NDT) (n = 22). The treatments were applied for 10 weeks (45-60 minutes/day, 3 days/week) for both of two groups. Nintendo Wii group used five games selected from the Wii sports and Wii Fit packages for upper limb and balance training, respectively. The patients in Bobath NDT group were applied a therapy program included upper extremity activites, strength, balance gait and functional training. The functional independence in daily life activities and health-related quality of life was assessed with Functional Independence Measure (FIM) and Nottingham Health Profile (NHP), respectively. Participant's treatment satisfaction was recorded by using Visual Analogue Scale. A second evaluation (FIM and NHP) occurred after 10 weeks at the end of rehabilitative treatment (post-training). Treatment satisfaction was measured after 10 sessions. There were significant difference between FIM and NHP values in NDT and Nintendo Wii group (p 0.05). The patients in Nintendo Wii group were detected to be better satisfied from the therapy (p Bobath NDT on daily living functions and quality of life in subacute stroke patients.

  11. Explaining the Microtubule Energy Balance: Contributions Due to Dipole Moments, Charges, van der Waals and Solvation Energy

    Directory of Open Access Journals (Sweden)

    Ahmed Taha Ayoub

    2017-09-01

    Full Text Available Microtubules are the main components of mitotic spindles, and are the pillars of the cellular cytoskeleton. They perform most of their cellular functions by virtue of their unique dynamic instability processes which alternate between polymerization and depolymerization phases. This in turn is driven by a precise balance between attraction and repulsion forces between the constituents of microtubules (MTs—tubulin dimers. Therefore, it is critically important to know what contributions result in a balance of the interaction energy among tubulin dimers that make up microtubules and what interactions may tip this balance toward or away from a stable polymerized state of tubulin. In this paper, we calculate the dipole–dipole interaction energy between tubulin dimers in a microtubule as part of the various contributions to the energy balance. We also compare the remaining contributions to the interaction energies between tubulin dimers and establish a balance between stabilizing and destabilizing components, including the van der Waals, electrostatic, and solvent-accessible surface area energies. The energy balance shows that the GTP-capped tip of the seam at the plus end of microtubules is stabilized only by − 9 kcal/mol, which can be completely reversed by the hydrolysis of a single GTP molecule, which releases + 14 kcal/mol and destabilizes the seam by an excess of + 5 kcal/mol. This triggers the breakdown of microtubules and initiates a disassembly phase which is aptly called a catastrophe.

  12. Watt and joule balances

    Science.gov (United States)

    Robinson, Ian A.

    2014-04-01

    The time is fast approaching when the SI unit of mass will cease to be based on a single material artefact and will instead be based upon the defined value of a fundamental constant—the Planck constant—h . This change requires that techniques exist both to determine the appropriate value to be assigned to the constant, and to measure mass in terms of the redefined unit. It is important to ensure that these techniques are accurate and reliable to allow full advantage to be taken of the stability and universality provided by the new definition and to guarantee the continuity of the world's mass measurements, which can affect the measurement of many other quantities such as energy and force. Up to now, efforts to provide the basis for such a redefinition of the kilogram were mainly concerned with resolving the discrepancies between individual implementations of the two principal techniques: the x-ray crystal density (XRCD) method [1] and the watt and joule balance methods which are the subject of this special issue. The first three papers report results from the NRC and NIST watt balance groups and the NIM joule balance group. The result from the NRC (formerly the NPL Mk II) watt balance is the first to be reported with a relative standard uncertainty below 2 × 10-8 and the NIST result has a relative standard uncertainty below 5 × 10-8. Both results are shown in figure 1 along with some previous results; the result from the NIM group is not shown on the plot but has a relative uncertainty of 8.9 × 10-6 and is consistent with all the results shown. The Consultative Committee for Mass and Related Quantities (CCM) in its meeting in 2013 produced a resolution [2] which set out the requirements for the number, type and quality of results intended to support the redefinition of the kilogram and required that there should be agreement between them. These results from NRC, NIST and the IAC may be considered to meet these requirements and are likely to be widely debated

  13. Balancing of generators at wind power plants. Operational balancing in normal operation at wind power plants; Auswuchten von Generatoren auf Windkraftanlagen. Betriebsauswuchten im Normalbetrieb der Windkraftanlage

    Energy Technology Data Exchange (ETDEWEB)

    Franke, Dieter [IDF vibrodiagnose GmbH, Dresden (Germany); Schmidt, Gerrit [WSB Service GmbH (Germany)

    2010-07-01

    An increasing or suddenly arising unbalanced state in the generator of a wind power plant can be recognized by means of condition monitoring systems and regularly accomplished oscillation diagnoses. A strong unbalanced state results in a fast bearing wear, increases the risk of outage and reduces the profit. The risk of a further damage of the generator by means of a clearly increased vibration severity often is substantial