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Sample records for activator spa influences

  1. MANAGEMENT AND DEVELOPMENT POSSIBILITIES FOR SPA TOURISM IN SERBIA

    Directory of Open Access Journals (Sweden)

    Nemanja BERBER

    2010-06-01

    Full Text Available Two forms of tourism, which are represented to a large extent in the world, are spa and wellness tourism. In Serbia, spa and wellness tourism are not sufficiently used, although there are excellent conditions. During twenty century the state was paying more attention and money on the sea and river tourism. However, the separation of Serbia and Montenegro in two independent counties had left Serbia without an entrance to the Adriatic Sea, so development of other tourist products and destinations became an imperative for survival and existence in the tourist map of Europe and the world. The paper presents the basic aims and policies of development of spa tourism in Serbia and data obtained in the survey regarding quality of services provided in some spa towns in Serbia. Based on the results to which the research occurred, authors wished to point out main activities and tasks that the state uses in creating a development strategy of spa tourism, the programs that have already been taken, so as the influence of the economic crisis to spa tourism.

  2. Spa47 is an oligomerization-activated type three secretion system (T3SS) ATPase from Shigella flexneri.

    Science.gov (United States)

    Burgess, Jamie L; Jones, Heather B; Kumar, Prashant; Toth, Ronald T; Middaugh, C Russell; Antony, Edwin; Dickenson, Nicholas E

    2016-05-01

    Gram-negative pathogens often use conserved type three secretion systems (T3SS) for virulence. The Shigella type three secretion apparatus (T3SA) penetrates the host cell membrane and provides a unidirectional conduit for injection of effectors into host cells. The protein Spa47 localizes to the base of the apparatus and is speculated to be an ATPase that provides the energy for T3SA formation and secretion. Here, we developed an expression and purification protocol, producing active Spa47 and providing the first direct evidence that Spa47 is a bona fide ATPase. Additionally, size exclusion chromatography and analytical ultracentrifugation identified multiple oligomeric species of Spa47 with the largest greater than 8 fold more active for ATP hydrolysis than the monomer. An ATPase inactive Spa47 point mutant was then engineered by targeting a conserved Lysine within the predicted Walker A motif of Spa47. Interestingly, the mutant maintained a similar oligomerization pattern as active Spa47, but was unable to restore invasion phenotype when used to complement a spa47 null S. flexneri strain. Together, these results identify Spa47 as a Shigella T3SS ATPase and suggest that its activity is linked to oligomerization, perhaps as a regulatory mechanism as seen in some related pathogens. Additionally, Spa47 catalyzed ATP hydrolysis appears to be essential for host cell invasion, providing a strong platform for additional studies dissecting its role in virulence and providing an attractive target for anti-infective agents. © 2016 The Protein Society.

  3. MxiN Differentially Regulates Monomeric and Oligomeric Species of the Shigella Type Three Secretion System ATPase Spa47.

    Science.gov (United States)

    Case, Heather B; Dickenson, Nicholas E

    2018-04-17

    Shigella rely entirely on the action of a single type three secretion system (T3SS) to support cellular invasion of colonic epithelial cells and to circumvent host immune responses. The ATPase Spa47 resides at the base of the Shigella needle-like type three secretion apparatus (T3SA), supporting protein secretion through the apparatus and providing a likely means for native virulence regulation by Shigella and a much needed target for non-antibiotic therapeutics to treat Shigella infections. Here, we show that MxiN is a differential regulator of Spa47 and that its regulatory impact is determined by the oligomeric state of the Spa47 ATPase, with which it interacts. In vitro and in vivo characterization shows that interaction of MxiN with Spa47 requires the six N-terminal residues of Spa47 that are also necessary for stable Spa47 oligomer formation and activation. This interaction with MxiN negatively influences the activity of Spa47 oligomers while upregulating the ATPase activity of monomeric Spa47. Detailed kinetic analyses of monomeric and oligomeric Spa47 in the presence and absence of MxiN uncover additional mechanistic insights into the regulation of Spa47 by MxiN, suggesting that the MxiN/Spa47 species resulting from interaction with monomeric and oligomeric Spa47 are functionally distinct and that both could be involved in Shigella T3SS regulation. Uncovering regulation of Spa47 by MxiN addresses an important gap in the current understanding of how Shigella controls T3SA activity and provides the first description of differential T3SS ATPase regulation by a native T3SS protein.

  4. Radioactivity of spa waters in Serbia

    International Nuclear Information System (INIS)

    Tanaskovic, I.; Eremic Savkovic, M.; Javorina, Lj.

    2011-01-01

    In this paper, the measurement results of: total alpha and beta activity, as well as specific activity of 226 Ra, 228 Ra, 40 K and conductivity of spa waters of Serbia, are presented. Spa water samples were taken in the fields of different types of geological environment. The maximum values of specific activity of 226 Ra, 228 Ra and 40 K were 0.53 Bq / l, [sr

  5. Spa-goers’ Characteristics, Motivations, Preferences and Perceptions: Evidence from Elounda, Crete

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    Nikolaos Trihas

    2016-12-01

    Full Text Available Spa and wellness tourism is one of the fastest-growing market segments in the hospitality and tourism industry. The aim of this study is to investigate and identify spa-goers’ characteristics, motivations, preferences and perceptions, providing a better understanding of the main features of this type of tourists’ behavior and expectations from a spa and wellness centre. Primary quantitative research was conducted via a structured questionnaire in a sample of 123 spa customers at Elounda in Crete. The results of the study revealed a number of important factors that influence them when choosing a spa, namely the cleanliness and the maintenance of a spa, the staff knowledge and hygiene, the personnel behavior and courtesy, and the quality of services. In addition, the main reason for visiting the spa is for stress relief/relaxation, followed by physical health improvement and beauty treatments. Findings and discussion of this study are useful to industry practitioners (spa and wellness service providers who wish to develop appropriate marketing strategies and enhance customer satisfaction and academic researchers interested in spa and wellness tourism.

  6. Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation*

    Science.gov (United States)

    Burgess, Jamie L.; Burgess, R. Alan; Morales, Yalemi; Bouvang, Jenna M.; Johnson, Sean J.; Dickenson, Nicholas E.

    2016-01-01

    Like many Gram-negative pathogens, Shigella rely on a complex type III secretion system (T3SS) to inject effector proteins into host cells, take over host functions, and ultimately establish infection. Despite these critical roles, the energetics and regulatory mechanisms controlling the T3SS and pathogen virulence remain largely unclear. In this study, we present a series of high resolution crystal structures of Spa47 and use the structures to model an activated Spa47 oligomer, finding that ATP hydrolysis may be supported by specific side chain contributions from adjacent protomers within the complex. Follow-up mutagenesis experiments targeting the predicted active site residues validate the oligomeric model and determined that each of the tested residues are essential for Spa47 ATPase activity, although they are not directly responsible for stable oligomer formation. Although N-terminal domain truncation was necessary for crystal formation, it resulted in strictly monomeric Spa47 that is unable to hydrolyze ATP, despite maintaining the canonical ATPase core structure and active site residues. Coupled with studies of ATPase inactive full-length Spa47 point mutants, we find that Spa47 oligomerization and ATP hydrolysis are needed for complete T3SS apparatus formation, a proper translocator secretion profile, and Shigella virulence. This work represents the first structure-function characterization of Spa47, uniquely complementing the multitude of included Shigella T3SS phenotype assays and providing a more complete understanding of T3SS ATPase-mediated pathogen virulence. Additionally, these findings provide a strong platform for follow-up studies evaluating regulation of Spa47 oligomerization in vivo as a much needed means of treating and perhaps preventing shigellosis. PMID:27770024

  7. Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation.

    Science.gov (United States)

    Burgess, Jamie L; Burgess, R Alan; Morales, Yalemi; Bouvang, Jenna M; Johnson, Sean J; Dickenson, Nicholas E

    2016-12-09

    Like many Gram-negative pathogens, Shigella rely on a complex type III secretion system (T3SS) to inject effector proteins into host cells, take over host functions, and ultimately establish infection. Despite these critical roles, the energetics and regulatory mechanisms controlling the T3SS and pathogen virulence remain largely unclear. In this study, we present a series of high resolution crystal structures of Spa47 and use the structures to model an activated Spa47 oligomer, finding that ATP hydrolysis may be supported by specific side chain contributions from adjacent protomers within the complex. Follow-up mutagenesis experiments targeting the predicted active site residues validate the oligomeric model and determined that each of the tested residues are essential for Spa47 ATPase activity, although they are not directly responsible for stable oligomer formation. Although N-terminal domain truncation was necessary for crystal formation, it resulted in strictly monomeric Spa47 that is unable to hydrolyze ATP, despite maintaining the canonical ATPase core structure and active site residues. Coupled with studies of ATPase inactive full-length Spa47 point mutants, we find that Spa47 oligomerization and ATP hydrolysis are needed for complete T3SS apparatus formation, a proper translocator secretion profile, and Shigella virulence. This work represents the first structure-function characterization of Spa47, uniquely complementing the multitude of included Shigella T3SS phenotype assays and providing a more complete understanding of T3SS ATPase-mediated pathogen virulence. Additionally, these findings provide a strong platform for follow-up studies evaluating regulation of Spa47 oligomerization in vivo as a much needed means of treating and perhaps preventing shigellosis. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  8. Health tourism in a Czech health spa.

    Science.gov (United States)

    Speier, Amy R

    2011-04-01

    This paper is about the changing shape of health tourism in a Czech spa town. The research focuses on balneotherapy as a traditional Czech healing technique, which involves complex drinking and bathing therapies, as it is increasingly being incorporated into the development of a Czech health tourism industry. Today, the health tourism industry in Mariánske Lázne is attempting to 'harmoniously' combine three elements--balneology, travel and business activities. One detects subtle shifts and consequent incongruities as doctors struggle for control over the medical portion of spa hotels. At the same time, marketing groups are creating new packages for a general clientele, and the implementation of these new packages de-medicalizes balneotherapy. Related to the issue of the doctor's authority in the spa, the changes occurring with the privatization of tourism entails the entrance of 'tourists' to Mariánske Lázne who are not necessarily seeking spa treatment but who are still staying at spa hotels. There is a general consensus among spa doctors and employees that balneotherapy has become commodified. Thus, while balneotherapy remains a traditional form of therapy, the commercial context in which it exists has created a new form of health tourism.

  9. Spa Products as Main Orientation in Wellness Tourism in Bali

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    I Gusti Made Wendri

    2018-03-01

    Full Text Available Wellness Spa is developed from conventional spa in response to the influence of the present tourism trend which is much in demand of the achievement of wellness aspect of life. Wellness tourism is a subdivision of health tourism. Wellness spa is the core product for wellness tourism. In fact, to date, people’s knowledge about wellness spa is still poor. This fact has motivated the implementation of this research under the title “Spa Products as Main Orientation in Wellness Tourism in Bali”. The objective of the research is to find out what products becomes the orientation in wellness tourism in Ubud as well as in South Badung. This qualitative research uses a phenomenological approach to the study. The determination of the informants is purposively done, and the information concerning the object of the research is obtained by deep interview controlled by a checklist based on Wellness Wheel concept. The location of the research is Ubud and South Badung areas, the latter represented by Nusa Dua, Jimbaran, and Kuta. The research uses 10 informants, 5 from Ubud and 5 from South Badung. The informants include spa managers and spa therapists. The result of the research shows that such packages as Bali spa ritual package, personal growth, and eco-adventure package become the most attractive products offered by wellness tourism industry and enjoyed by the tourists for the fulfilment of the tourists' wellness needs.

  10. Radioactivity measurements and risk assessments of spa waters in some areas in Turkey.

    Science.gov (United States)

    Duran, Selcen Uzun; Kucukomeroglu, Belgin; Damla, Nevzat; Taskin, Halim; Celik, Necati; Cevik, Uğur; Ersoy, Hakan

    2017-03-01

    The current study presents the results of the activity of radionuclides in spa waters, and evaluates their radiological influences on the population consuming these waters in the Central and Eastern Black Sea regions of Turkey. Since these waters are used for therapy and consumption purposes unconsciously, their radiological impact on the people was computed by taking into consideration the annual intake through ingestion of 226 Ra, 232 Th, 40 K, 137 Cs and 222 Rn. The mean activities were estimated to be 11.35 for gross alpha, 6.23 for gross beta, 2.96 for 226 Ra, 0.42 for 232 Th, 0.069 for 137 Cs, 0.19 for 40 K, and 267 Bq L -1 for 222 Rn, respectively. The estimated effective doses from spa water were found to be 49.77 µSv a -1 ( 226 Ra), 5.95 µSv a -1 ( 232 Th), 0.07 µSv a -1 ( 137 Cs), 0.83 µSv a -1 ( 40 K) and 56.03 µSv a -1 ( 222 Rn). These values were evaluated and compared with related verified values from literature. Also, physico-chemical characterizations of spa water samples considered in the current study were investigated. This study would be useful for consumers and official authorities for the assessment of radiation exposure risk due to usage of the considered spa waters.

  11. Effect of spa therapy with saline balneotherapy on oxidant/antioxidant status in patients with rheumatoid arthritis: a single-blind randomized controlled trial

    Science.gov (United States)

    Karagülle, Mine; Kardeş, Sinan; Karagülle, Oğuz; Dişçi, Rian; Avcı, Aslıhan; Durak, İlker; Karagülle, Müfit Zeki

    2017-01-01

    Oxidative stress has been shown to play a contributory role in the pathogenesis of rheumatoid arthritis (RA). Recent studies have provided evidence for antioxidant properties of spa therapy. The purpose of this study is to investigate whether spa therapy with saline balneotherapy has any influence on the oxidant/antioxidant status in patients with RA and to assess clinical effects of spa therapy. In this investigator-blind randomized controlled trial, we randomly assigned 50 patients in a 1:1 ratio to spa therapy plus standard drug treatment (spa group) or standard drug treatment alone (control group). Spa group followed a 2-week course of spa therapy regimen consisting of a total of 12 balneotherapy sessions in a thermal mineral water pool at 36-37 °C for 20 min every day except Sunday. All clinical and biochemical parameters were assessed at baseline and after spa therapy (2 weeks). The clinical parameters were pain intensity, patient global assessment, physician global assessment, Health Assessment Questionnaire disability index (HAQ-DI), Disease Activity Score for 28-joints based on erythrocyte sedimentation rate (DAS28-4[ESR]). Oxidative status parameters were malondialdehyde (MDA), nonenzymatic superoxide radical scavenger activity (NSSA), antioxidant potential (AOP), and superoxide dismutase (SOD). The NSSA levels were increased significantly in the spa group ( p = 0.003) but not in the control group ( p = 0.509); and there was a trend in favor of spa therapy for improvements in NSSA levels compared to control ( p = 0.091). Significant clinical improvement was found in the spa group compared to the control in terms of patient global assessment ( p = 0.011), physician global assessment ( p = 0.043), function (HAQ-DI) ( p = 0.037), disease activity (DAS28-4[ESR]) (0.044) and swollen joint count (0.009), and a trend toward improvement in pain scores (0.057). Spa therapy with saline balneotherapy exerts antioxidant effect in patients with RA as reflected by the

  12. Formation of trihalomethanes as disinfection byproducts in herbal spa pools.

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    Fakour, Hoda; Lo, Shang-Lien

    2018-04-09

    Herbal spa treatments are favorite recreational activities throughout the world. The water in spas is often disinfected to control pathogenic microorganisms and guarantee hygiene. However, chlorinated water may cause the formation of disinfection byproducts (DBPs). Although there have been many studies on DBP formation in swimming pools, the role of organic matter derived from herbal medicines applied in herbal spa water has been largely neglected. Accordingly, the present study investigated the effect of herbal medicines on the formation of trihalomethanes (THMs) in simulated herbal spa water. Water samples were collected from a spa pool, and then, disinfection and herbal addition experiments were performed in a laboratory. The results showed that the organic molecules introduced by the herbal medicines are significant precursors to the formation of THMs in spa pool water. Since at least 50% of THMs were produced within the first six hours of the reaction time, the presence of herbal medicines in spa water could present a parallel route for THM exposure. Therefore, despite the undeniable benefits of herbal spas, the effect of applied herbs on DBP formation in chlorinated water should be considered to improve the water quality and health benefits of spa facilities.

  13. PERFORMANCE ANALYSIS ON SPA SERVICE AT BADUNG DAN GIANYAR REGENCIES

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    Dewa Ayu i Laksmiadi Janapriat

    2016-03-01

    Full Text Available Over the last ten years, spa as one of the products of wellness tourism is growing very fast in Bali, necessitating the development strategy in accordance with the conditions of Bali. The rapid development momentum for the business of spa is opened in Bali, although in the external side of the business will compete with the international trade environment to take advantage and create sustainable economic growth prospects. This will be an opportunity for Bali as a destination spa in the future. In an effort to maintain and continue to develop quality as the best spa destinations in the world, we need the right strategy to make the creation and supporting product innovation spa in Bali. This study aims to create an integrated assessment of the extent of the influence of the utilization of natural resources, human resources and local knowledge of the existence and essence of spa in Bali and methods for utilizing natural resources, human resources and local knowledge of Bali on development of spa in Bali. Research design and methods of approach to the problem that are done in this study using descriptive design, where the planning and execution of research conducted in the form of field data are collected in the form of surveys, questionnaires and statistical data processing. The target population in this study is divided into three, namely: the company or a place that offers spa services, spa services supporting manufacturers and both foreign and domestic tourists who use the services of spa services in Badung and Gianyar, by assuming the two districts can represent the tourist population to Bali. Based on several case studies found that the performance of spa services in terms of utilization of natural resources, human resources, and local wisdom of Bali, particularly in terms of (1 the atmosphere (ambience, (2 equipment and design, (3 the qualifications and skills of the therapist, (4 treatment menu, and (5 the quality of services as a whole has

  14. SP-A binding sites on bovine alveolar macrophages.

    Science.gov (United States)

    Plaga, S; Plattner, H; Schlepper-Schaefer, J

    1998-11-25

    Surfactant protein A (SP-A) binding to bovine alveolar macrophages was examined in order to characterize SP-A binding proteins on the cell surface and to isolate putative receptors from these cells that could be obtained in large amounts. Human SP-A, unlabeled or labeled with gold particles, was bound to freshly isolated macrophages and analyzed with ELISA or the transmission electron microscope. Binding of SP-A was inhibited by Ca2+ chelation, by an excess of unlabeled SP-A, or by the presence of 20 mg/ml mannan. We conclude that bovine alveolar macrophages expose binding sites for SP-A that are specific and that depend on Ca2+ and on mannose residues. For isolation of SP-A receptors with homologous SP-A as ligand we isolated SP-A from bovine lung lavage. SDS-PAGE analysis of the purified SP-A showed a protein of 32-36 kDa. Functional integrity of the protein was demonstrated. Bovine SP-A bound to Dynabeads was used to isolate SP-A binding proteins. From the fractionated and blotted proteins of the receptor preparation two proteins bound SP-A in a Ca2+-dependent manner, a 40-kDa protein showing mannose dependency and a 210-kDa protein, showing no mannose sensitivity. Copyright 1998 Academic Press.

  15. Development of a Scintillation Proximity Assay (SPA) Based, High Throughput Screening Feasible Method for the Identification of PDE12 Activity Modulators.

    Science.gov (United States)

    Mang, Samuel; Bucher, Hannes; Nickolaus, Peter

    2016-01-01

    The scintillation proximity assay (SPA) technology has been widely used to establish high throughput screens (HTS) for a range of targets in the pharmaceutical industry. PDE12 (aka. 2'- phosphodiesterase) has been published to participate in the degradation of oligoadenylates that are involved in the establishment of an antiviral state via the activation of ribonuclease L (RNAse-L). Degradation of oligoadenylates by PDE12 terminates these antiviral activities, leading to decreased resistance of cells for a variety of viral pathogens. Therefore inhibitors of PDE12 are discussed as antiviral therapy. Here we describe the use of the yttrium silicate SPA bead technology to assess inhibitory activity of compounds against PDE12 in a homogeneous, robust HTS feasible assay using tritiated adenosine-P-adenylate ([3H]ApA) as substrate. We found that the used [3H]ApA educt, was not able to bind to SPA beads, whereas the product [3H]AMP, as known before, was able to bind to SPA beads. This enables the measurement of PDE12 activity on [3H]ApA as a substrate using a wallac microbeta counter. This method describes a robust and high throughput capable format in terms of specificity, commonly used compound solvents, ease of detection and assay matrices. The method could facilitate the search for PDE12 inhibitors as antiviral compounds.

  16. Radon and progeny sourced dose assessment of spa employees in balneological sites

    International Nuclear Information System (INIS)

    Kemal Uzun, Sefa; Demiroez, Isik

    2016-01-01

    This study was conducted in the scope of IAEA project with the name 'Establishing a Systematic Radioactivity Survey and Total Effective Dose Assessment in Natural Balneological Sites' (TUR/9/018), at the Health Physics department of Saraykoey Nuclear Research and Training Center (SANAEM). The aim of this study is estimation of radon and progeny sourced effective dose for the people who are working at the spa facilities by measuring radon activity concentration (RAC) at the ambient air of indoor spa pools and dressing rooms. As it is known, the source of the radon gas is the radium content of the earth crust. Therefore, thermal waters coming from ground may contain dissolved radon and the radon can diffuse water to air. So the ambient air of spa pools can contain serious RAC that depends on a lot of parameters. In this regard, RAC measurements were executed at the 70 spa facilities in Turkey. The measurements were done with both active and passive methods at ambient air of spa pools and dressing rooms. Thus, active measurements were carried out by using the Alphaguard R with diffusion mode during half an hour, and passive measurements were carried out by using the humidity resistive CR-39 radon detectors during 2 months. Results show that RAC values at ambient air of spa pools varies between 13 Bq m -3 and 10 kBq m -3 . Because long-term measurements are more reliable, if it is available, for dose calculations passive radon measurements (with CR-39 detectors) at ambient air of spa pools and dressing rooms were used, otherwise active measurement results were used. With the measurement by the conversion coefficients of ICRP 65 and occupational data of the employees has got from questionnaire forms, effective dose values were calculated. According to the calculations, spa employees are exposed to annual average dose between 0.05 and 29 mSv because of radon and progeny. (authors)

  17. Aplicació Microsoft .Net : Hotel Spa

    OpenAIRE

    Marquès Palmer, Jordi

    2010-01-01

    Desenvolupament d'una aplicació amb Microsoft .NET, WCF, WPF, Linq2SQL, d'un Hotel Spa. Desarrollo de una aplicación con Microsoft .NET, WCF, WPF, Linq2SQL, de un Hotel Spa. Application development using Microsoft .NET, WCF, WPF, Linq2SQL, for a Spa Hotel.

  18. Harnn Natural Home Spa Business Plan

    OpenAIRE

    Kusol, Chompunuch

    2008-01-01

    Home Spa Partnership is looking for the amount of 50,000 GBP from an investor to invest in the business. The Company offers 20% of its authorised share capital for 17,500 GBP and the preference shares amounting to 32,500 GBP. This amount will be brought into the infrastructures and initial overhead cost for the start-up Thai spa business in the UK under 'Harnn Natural Home Spa' brand. The Company Home Spa Partnership was incorporated in July 2008 with issued share capital of 80,000...

  19. Spa therapy adjunct to pharmacotherapy is beneficial in rheumatoid arthritis: a crossover randomized controlled trial

    Science.gov (United States)

    Karagülle, Mine; Kardeş, Sinan; Dişçi, Rian; Karagülle, Müfit Zeki

    2018-02-01

    This study aims to investigate whether 2-week spa therapy, as an adjunct to usual pharmacological therapy, has any beneficial effect in patients with rheumatoid arthritis (RA). In this single-blind crossover study, 50 patients were randomly assigned in a 1:1 manner to receive usual pharmacological therapy plus 2-week spa therapy or usual pharmacological therapy alone (period 1.6 months); after a 9-month washout, patients were crossed over to the opposite assignment (period 2.6 months). Spa therapy program included a daily saline balneotherapy session at 36-37 °C for 20 min except Sundays. The clinical outcomes were evaluated at baseline, after spa therapy (2 weeks) and 3 and 6 months after the spa therapy in both period and were pain (Visual Analogue Scale (VAS)), patient and physician global assessments (VAS), Health Assessment Questionnaire (HAQ), and Disease Activity Score (DAS28). Spa therapy was superior to control therapy in improving all the assessed clinical outcomes at the end of the spa therapy. This superiority persisted significantly in physician global assessment ( p = 0.010) and with a trend in favor of spa group in patient global assessment ( p = 0.058), function ( p = 0.092), and disease activity ( p = 0.098) at 3 months. Statistically significant improvements were found in spa therapy compared to control in disease activity ( p = 0.006) and patient ( p = 0.020) and physician global ( p = 0.011) assessments, and a trend toward improvements in pain ( p = 0.069) and swollen joints ( p = 0.070) at 6 months. A 2-week spa therapy adjunct to usual pharmacological therapy provided beneficial clinical effects compared to usual pharmacological therapy alone, in RA patients treated with traditional disease-modifying antirheumatic drugs. These beneficial effects may last for 6 months.

  20. Effects of balneotherapy and spa therapy on levels of cortisol as a stress biomarker: a systematic review

    Science.gov (United States)

    Antonelli, Michele; Donelli, Davide

    2018-02-01

    Balneotherapy and spa therapy are well-known practices, even though limited evidence has been produced about their biological effects. This systematic review primarily aims at assessing if balneotherapy, mud/peloid therapy, and spa therapy may influence cortisol levels. Secondarily, it aims at understanding if these interventions may improve stress resilience. PubMed/Medline, Embase, and Cochrane Library were searched for relevant articles in English or Italian about studies involving healthy and sub-healthy subjects or patients with a diagnosed disease about effects of balneotherapy, mud/peloid therapy, and spa therapy on serum and salivary cortisol levels. Fifteen studies involving 684 subjects were included. Five studies investigated biological effects of balneotherapy alone. Two of them reported significant changes of cortisol levels in healthy participants. The other three studies reported no significant variations in patients with rheumatic conditions. No studies investigated biological effects of mud/peloid therapy alone. Ten studies investigated biological effects of spa therapy with or without included mud/peloid therapy, and in all but two studies, significant variations of cortisol levels were reported. Our main findings suggest that balneotherapy may have the potential to influence cortisol levels in healthy subjects, in such a way as to improve stress resilience. Spa therapy with or without included mud/peloid therapy demonstrated the same potential to influence cortisol levels also in sub-healthy subjects and in patients with a diagnosed disease. Therefore, balneotherapy and spa therapy may be considered as useful interventions for the management of stress conditions. Further investigation is needed because of limited available data.

  1. PREREQUISITES FOR DEVELOPMENT OF SPA TOURISM IN BULGARIA

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    Manuela Vucheva

    2016-12-01

    Full Text Available The demand for spa tourism in Bulgaria has increased 3 times in the last five years. Worldwide demand for spa for travel increased 2 times since 2004. Indications show that spa tourism is developing in a positive direction, both in Bulgaria and abroad. In Bulgaria there are 25 spa destinations where there are hydromineral fields and complexes for accommodation and rest. The paper provides key conclusions in relation to the development of spa tourism in Bulgaria and recommendations for improvements in marketing and advertising and combination with other types of tourism.

  2. THE INFLUENCE OF CROSS-TRAINING DUE TO SPA TREATMENT IN CURRING FUNCTIONAL NEUROTIC DISORDERS

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    Rade Stefanović

    2006-06-01

    Full Text Available Modern civilization moves to endless automation and mechanization. This fact, in one hand, has positive effect on increase of life standard, but also carries its own risks and threats of mankind. Axelberg, famous academician, makes an interesting remark that only a hundred years ago man did 96 % of his work by himself, while today most manufacturing processes are 100% automated. Stress, lack of physical activity and bad food regime are canses of organic damages of cardiopulmonary system. Latest research, conducted in many countries, shows that for proper functioning of every organism the minimum of moving is necessary.Term neurosis was introduced in medical literature by Scottish doctor W. Cullen in 1777. By that term were considered different clinical appearances which are believed neurotic todey, but also the phenomena today considered as psychosomatic disorders of character and behavior. Pavlov’s reflexive theory is basic in treatment of some types of neurossis’ during spa treatments in Nerečinska Banja. It usually starts at the beginning of May and ends in October, but sometimes if weather is nice, it can last until the middle of November. The treatment cure last tventy-one day, doesn’t include medicaments, but only spa water, baths and massage.

  3. Microfibril-associated Protein 4 Binds to Surfactant Protein A (SP-A) and Colocalizes with SP-A in the Extracellular Matrix of the Lung

    DEFF Research Database (Denmark)

    Schlosser, Anders; Thomsen, Theresa H.; Shipley, J. Michael

    2006-01-01

    for phagocytes. Here we describe the molecular interaction between the extracellular matrix protein microfibril-associated protein 4 (MFAP4) and SP-A. MFAP4 is a collagen-binding molecule containing a C-terminal fibrinogen-like domain and a N-terminal located integrin-binding motif. We produced recombinant MFAP4......-A composed of the neck region and carbohydrate recognition domain of SP-A indicating that the interaction between MFAP4 and SP-A is mediated via the collagen domain of SP-A. Monoclonal antibodies directed against MFAP4 and SP-A were used for immunohistochemical analysis, which demonstrates that the two...... molecules colocalize both on the elastic fibres in the interalveolar septum and in elastic lamina of pulmonary arteries of chronically inflamed lung tissue. We conclude, that MFAP4 interacts with SP-A via the collagen region in vitro, and that MFAP4 and SP-A colocates in different lung compartments...

  4. Spa therapy in dermatology

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    Najeeba Riyaz

    2011-01-01

    Full Text Available Spa therapy constitutes the use of mineral springs and thermal mud to soothe and heal various ailments. Like the mineral springs, seas and oceans are also important centers for spa therapy of which the most important is Dead Sea (DS. DS has been famous for thousands of years for its miraculous curative and cosmetic properties. Intensive research is going on using DS minerals in a wide range of dermatological conditions especially psoriasis, atopic dermatitis, vitiligo and other eczemas and several papers have been published in various international and pharmacological journals.

  5. Correlation of the sperm penetration assay (SPA and miscarriage after assisted reproduction: The potential use of spa as a new criterion for preimplantation genetic diagnosis

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    Gradistanac Jelena

    2011-01-01

    Full Text Available We analyzed 93 couples undergoing male screening with the Sperm Penetration Assay (SPA before in vitro fertilization and intracytoplasmic sperm injection (ICSI, to determine the accuracy of SPA for subsequent embryonic development, incidence of pregnancy and miscarriage rates (SAB. ICSI patients with the lowest SPA scores had significantly higher incidences of Sthan did patients in the other SPA groups. Sperm quality is higher with better SPA scores. Poor sperm quality has increased incidence of chromosomal abnormalities and is associated with early fetal loss. Couples with negative SPA are candidates for preimplantation genetic diagnosis, to reduce the incidence of SAB.

  6. Phenotypical analysis of the Lactobacillus rhamnosus GG fimbrial spaFED operon: surface expression and functional characterization of recombinant SpaFED pili in Lactococcus lactis.

    Directory of Open Access Journals (Sweden)

    Johanna Rintahaka

    Full Text Available A noticeable genomic feature of many piliated Gram-positive bacterial species is the presence of more than one pilus-encoding operon. Paradigmatically, the gut-adapted Lactobacillus rhamnosus GG strain contains two different fimbrial operons in its genome. However, whereas one of these operons (called spaCBA is encoding for the functionally mucus-/collagen-binding SpaCBA pilus, for the other operon (called spaFED any native expression of the SpaFED-called pili is still the subject of some uncertainty. Irrespective of such considerations, we decided it would be of relevance or interest to decipher the gross structure of this pilus type, and as well assess its functional capabilities for cellular adhesion and immunostimulation. For this, and by following the approach we had used previously to explicate the immuno-properties of SpaCBA pili, we constructed nisin-inducible expression clones producing either wild-type or SpaF pilin-deleted surface-assembled L. rhamnosus GG SpaFED pili on Lactococcus lactis cells. Using these piliated lactococcal constructs, we found that the pilin-polymerized architecture of a recombinant-produced SpaFED pilus coincides with sequence-based functional predictions of the related pilins, and in fact is prototypical of those other sortase-dependent pilus-like structures thus far characterized for piliated Gram-positive bacteria. Moreover, we confirmed that among the different pilin subunits encompassing spaFED operon-encoded pili, the SpaF pilin is a main adhesion determinant, and when present in the assembled structure can mediate pilus binding to mucus, certain extracellular matrix proteins, and different gut epithelial cell lines. However, somewhat unexpectedly, when recombinant SpaFED pili are surface-attached, we found that they could not potentiate the existing lactococcal cell-induced immune responses so elicited from intestinal- and immune-related cells, but rather instead, they could dampen them. Accordingly, we

  7. Phenotypical analysis of the Lactobacillus rhamnosus GG fimbrial spaFED operon: surface expression and functional characterization of recombinant SpaFED pili in Lactococcus lactis.

    Science.gov (United States)

    Rintahaka, Johanna; Yu, Xia; Kant, Ravi; Palva, Airi; von Ossowski, Ingemar

    2014-01-01

    A noticeable genomic feature of many piliated Gram-positive bacterial species is the presence of more than one pilus-encoding operon. Paradigmatically, the gut-adapted Lactobacillus rhamnosus GG strain contains two different fimbrial operons in its genome. However, whereas one of these operons (called spaCBA) is encoding for the functionally mucus-/collagen-binding SpaCBA pilus, for the other operon (called spaFED) any native expression of the SpaFED-called pili is still the subject of some uncertainty. Irrespective of such considerations, we decided it would be of relevance or interest to decipher the gross structure of this pilus type, and as well assess its functional capabilities for cellular adhesion and immunostimulation. For this, and by following the approach we had used previously to explicate the immuno-properties of SpaCBA pili, we constructed nisin-inducible expression clones producing either wild-type or SpaF pilin-deleted surface-assembled L. rhamnosus GG SpaFED pili on Lactococcus lactis cells. Using these piliated lactococcal constructs, we found that the pilin-polymerized architecture of a recombinant-produced SpaFED pilus coincides with sequence-based functional predictions of the related pilins, and in fact is prototypical of those other sortase-dependent pilus-like structures thus far characterized for piliated Gram-positive bacteria. Moreover, we confirmed that among the different pilin subunits encompassing spaFED operon-encoded pili, the SpaF pilin is a main adhesion determinant, and when present in the assembled structure can mediate pilus binding to mucus, certain extracellular matrix proteins, and different gut epithelial cell lines. However, somewhat unexpectedly, when recombinant SpaFED pili are surface-attached, we found that they could not potentiate the existing lactococcal cell-induced immune responses so elicited from intestinal- and immune-related cells, but rather instead, they could dampen them. Accordingly, we have now provided

  8. Influence balneotherapy on spa Truskavets’ with taking Canephron® N on urina lithogenicity and its metabolic and neuroendocrine-immune accompaniments in patients with chronic pyelonephrite and cholecystite

    Directory of Open Access Journals (Sweden)

    Oleksandr V. Shulyak

    2015-11-01

    i.popovych@biph.kiev.ua   SUMMARY Objective. We know that balneotherapy on spa Truskavets' did not significantly affect the parameters of urina Lithogenicity, including Ca/Mg ratio, so search for means of reducing urina Lithogenicity remains relevant. We also know that Phytopreparation Canephron® N recommended for inclusion in complex therapy of chronic pyelonephrite as effective elimination of infectious kidney inflammation, prevention of recurrence of inflammation and lithogenese. Aim: to find out the possibility of reducing urina Lithogenicity influenced balneotherapy on spa Truskavets' by additional taking Canephron® N. Results. Standardized balneotherapy not significantly affect urina Lithogenicity in patients with chronic pyelonephrite and cholecystite, even showed a trend to increase, while additional use Canephron® N significantly reduces urina Lithogenicity by reducing the concentration of Uric acid and downward trend Calcium. Reducing urina Lithogenicity accompanied by a decrease urina concentration Chloride and Potassium, and Baevskiy’s Activity Regulatory Systems Index, Asymmetry δ-, θ- and α-rhythms of background EEG and α-rhythm normalized Power Spectrum Density (PSD in right loci Fp2, F8, T6 and O2, while HRV markers of vagal tone (RMSSD, pNN50, TI also Frequency Deviation θ- and β-rhythms, Amplitude β- and δ-rhythms, δ-rhythm PSD in loci Fp2, F8, T3, T5, O1, O2, β-rhythm PSD in loci Fp1, F4 and θ-rhythm PSD in loci T3 and F7 rising. However, Canephron® N preventes or reverses increasing Uric acid plasma level, Mineralocorticoide Activity, Sympathetic tone, Baevskiy’s Stress Index and PSD ULF HRV also decreasing PSD VLF HRV. Concerning parameters of Immunity Canephron® N decreases blood level active T-Lymphocytes but increases level B-Lymphocytes, Stubnucleary Neutrophiles and total Leukocytes also prevents or reverses increasing CD16+ NK-Lymphocytes, CD8+ and Theophilinesensitive T-Lymphocytes, Monocytes and serum IgM also

  9. Spa and Wellness Tourism in Slovakia (A Geographical Analysis

    Directory of Open Access Journals (Sweden)

    Kasagranda Anton

    2017-06-01

    Full Text Available Spa industry is presently an inherent part of Slovak tourism. For this reason, it has become a major interest of scientific and professional literature (economics, management, sociology, or geography. The main topic of this paper is the evaluation of tourism in Slovakia through a geographic analysis. This paper briefly evaluates the development and the importance of spa, spa tourism and wellness and their main research areas and issues. Furthermore, the primary sources of tourism development, the overview of spa tourism and the wellness resorts, the accommodation establishments and the visitation rate are evaluated as well. In conclusion, functional and spatial typification of spa tourism and wellness in Slovakia is presented. The structure of the paper is designed to be appropriate for a comparison with V4 countries.

  10. Impact to Tourism Industry of Massage Spa Therapy in Batangas City, Philippines

    Directory of Open Access Journals (Sweden)

    Kimmy Lei T. Atienza

    2014-10-01

    Full Text Available This study aimed to assess the benefits of massage spa therapy in tourism industry of Batangas City and their adherence to the standards to DOT on Spa operation and maintenance. The study aimed to identify the profile of massage spa in terms of type of ownership, length of years in the business, type of spa and different spa services offered; to assess the benefits of massage spa to the tourism industry; and to determine the extent of adherence of the massage spa to DOT standards about spa operation and maintenance; and propose a plan of action based on the results of the study. Descriptive method was used in the study. Results showed that the Sole Proprietorship got the highest rank in terms of type of ownership. With the length of years in service, it shows that most of spa business already exists for 4-6 years. Type of spa shows that majority of the spa business were Spa Town. With regards to different spa services, majority offers peat pulp bath and the least is sauna and steam bath. The over-all assessment of the respondents’ on the benefits of spa was agree by the result. It was also observed that all items were assessed as agree and it enhances the awareness of the tourists about the beauty of Batangas City. It was followed by provide taxes for the government, became a tourist attraction and improves socio-economic of local residents and improvement on the lifestyle both of the local residents and tourists

  11. Strand SPA & Konverentsikeskus

    Index Scriptorium Estoniae

    2008-01-01

    Strand SPA & Konverentsikeskus on Pärnu suurim äri- ja konverentsiklientidele suunatud hotell, mis klientide seas on hinnatud just selle kompleksuse tõttu, kuna kõik, mida külaline vajab ja soovib, on olemas ühe katuse all

  12. Genomic and Functional Characterization of the Unusual pLOCK 0919 Plasmid Harboring the spaCBA Pili Cluster in Lactobacillus casei LOCK 0919

    Science.gov (United States)

    Aleksandrzak-Piekarczyk, Tamara; Koryszewska-Bagińska, Anna; Grynberg, Marcin; Nowak, Adriana; Cukrowska, Bożena; Kozakova, Hana; Bardowski, Jacek

    2016-01-01

    Here, we report the extensive bioinformatic and functional analyses of the unusual pLOCK 0919, a plasmid originating from the probiotic Lactobacillus casei LOCK 0919 strain. This plasmid is atypical because it harbors the spaCBA-srtC gene cluster encoding SpaCBA pili. We show that all other spaCBA-srtC sequences of the Lactobacillus genus that have been previously described and deposited in GenBank are present in the chromosomal DNA. Another important observation for pLOCK 0919 is that the spaCBA-srtC gene cluster and its surrounding genes are highly similar to the respective DNA region that is present in the most well-known and active SpaCBA pili producer, the probiotic Lactobacillus rhamnosus GG strain. Our results demonstrate that the spaCBA-srtC clusters of pLOCK 0919 and L. rhamnosus GG are genealogically similar, located in DNA regions that are rich in transposase genes and are poorly conserved among the publicly available sequences of Lactobacillus sp. In contrast to chromosomally localized pilus gene clusters from L. casei and Lactobacillus paracasei, the plasmidic spaC of L. casei LOCK 0919 is expressed and undergoes a slight glucose-induced repression. Moreover, results of series of in vitro tests demonstrate that L. casei LOCK 0919 has an adhesion potential, which is largely determined by the presence of the pLOCK 0919 plasmid. In particular, the plasmid occurrence positively influenced the hydrophobicity and aggregation abilities of L. casei LOCK 0919. Moreover, in vivo studies indicate that among the three Lactobacillus strains used to colonize the gastrointestinal tract of germ-free mice, already after 2 days of colonization, L. casei LOCK 0919 became the dominant strain and persisted there for at least 48 days. PMID:26637469

  13. Non-spa-typeable clinical Staphylococcus aureus strains are naturally occurring protein A mutants

    DEFF Research Database (Denmark)

    Baum, Cathrin; Haslinger-Löffler, Bettina; Westh, Henrik

    2009-01-01

    Staphylococcus aureus is a major human pathogen responsible for increasing the prevalence of community- and hospital-acquired infections. Protein A (SpA) is a key virulence factor of S. aureus and is highly conserved. Sequencing of the variable-number tandem-repeat region of SpA (spa typing......) provides a rapid and reliable method for epidemiological studies. Rarely, non-spa-typeable S. aureus strains are encountered. The reason for this is not known. In this study, we characterized eight non-spa-typeable bacteremia isolates. Sequencing of the entire spa locus was successful for five strains...... and revealed various mutations of spa, all of which included a deletion of immunoglobulin G binding domain C, in which the upper primer for spa typing is located, while two strains were truly spa negative. This is the first report demonstrating that nontypeability of S. aureus by spa sequencing is due either...

  14. Role of surfactant protein-A (SP-A) in lung injury in response to acute ozone exposure of SP-A deficient mice

    International Nuclear Information System (INIS)

    Haque, Rizwanul; Umstead, Todd M.; Ponnuru, Padmavathi; Guo Xiaoxuan; Hawgood, Samuel; Phelps, David S.; Floros, Joanna

    2007-01-01

    Millions are exposed to ozone levels above recommended limits, impairing lung function, causing epithelial damage and inflammation, and predisposing some individuals to pneumonia, asthma, and other lung conditions. Surfactant protein-A (SP-A) plays a role in host defense, the regulation of inflammation, and repair of tissue damage. We tested the hypothesis that the lungs of SP-A(-/-) (KO) mice are more susceptible to ozone-induced damage. We compared the effects of ozone on KO and wild type (WT) mice on the C57BL/6 genetic background by exposing them to 2 parts/million of ozone for 3 or 6 h and sacrificing them 0, 4, and 24 h later. Lungs were subject to bronchoalveolar lavage (BAL) or used to measure endpoints of oxidative stress and inflammation. Despite more total protein in BAL of KO mice after a 3 h ozone exposure, WT mice had increased oxidation of protein and had oxidized SP-A dimers. In KO mice there was epithelial damage as assessed by increased LDH activity and there was increased phospholipid content. In WT mice there were more BAL PMNs and elevated macrophage inflammatory protein (MIP)-2 and monocyte chemoattractant protein (MCP)-1. Changes in MIP-2 and MCP-1 were observed in both KO and WT, however mRNA levels differed. In KO mice MIP-2 mRNA levels changed little with ozone, but in WT levels they were significantly increased. In summary, several aspects of the inflammatory response differ between WT and KO mice. These in vivo findings appear to implicate SP-A in regulating inflammation and limiting epithelial damage in response to ozone exposure

  15. State, planning and design of Jodna spa in Novi Sad

    Directory of Open Access Journals (Sweden)

    Garača Vuk

    2012-01-01

    Full Text Available The paper treats the area of Jodna spa in Novi Sad, which largely coincides with Futoški park, making with it the indissoluble unity. The main problem in the functioning of the Jodna psa is the fact that in legal sense Jodna spa does not exists, and in spatial sense there are still all of its content. The case of the paper is Jodna spa area, which includes the Special Hospital for Rheumatic Diseases, Hotel 'Park', Sports Center 'Sajmište' and Futoški park, which integrate them. The question of the Jodna spa planning, as well as the modern city recreation, spa and tourist center, is the goal of this paper. For this purpose it was necessary to show the historical background of the development of Jodna spa, to make the assessment of the state, critically analyze spatial plans which treat it and provide concrete suggestions for its design and equipping.

  16. Insulin utilizes the PI 3-kinase pathway to inhibit SP-A gene expression in lung epithelial cells

    Directory of Open Access Journals (Sweden)

    Snyder Jeanne M

    2002-10-01

    Full Text Available Abstract Background It has been proposed that high insulin levels may cause delayed lung development in the fetuses of diabetic mothers. A key event in lung development is the production of adequate amounts of pulmonary surfactant. Insulin inhibits the expression of surfactant protein A (SP-A, the major surfactant-associated protein, in lung epithelial cells. In the present study, we investigated the signal transduction pathways involved in insulin inhibition of SP-A gene expression. Methods H441 cells, a human lung adenocarcinoma cell line, or human fetal lung explants were incubated with or without insulin. Transcription run-on assays were used to determine SP-A gene transcription rates. Northern blot analysis was used to examine the effect of various signal transduction inhibitors on SP-A gene expression. Immunoblot analysis was used to evaluate the levels and phosphorylation states of signal transduction protein kinases. Results Insulin decreased SP-A gene transcription in human lung epithelial cells within 1 hour. Insulin did not affect p44/42 mitogen-activated protein kinase (MAPK phosphorylation and the insulin inhibition of SP-A mRNA levels was not affected by PD98059, an inhibitor of the p44/42 MAPK pathway. In contrast, insulin increased p70 S6 kinase Thr389 phosphorylation within 15 minutes. Wortmannin or LY294002, both inhibitors of phosphatidylinositol 3-kinase (PI 3-kinase, or rapamycin, an inhibitor of the activation of p70 S6 kinase, a downstream effector in the PI 3-kinase pathway, abolished or attenuated the insulin-induced inhibition of SP-A mRNA levels. Conclusion Insulin inhibition of SP-A gene expression in lung epithelial cells probably occurs via the rapamycin-sensitive PI 3-kinase signaling pathway.

  17. Radon in the spa of Bizovac

    International Nuclear Information System (INIS)

    Planinic, J.; Faj, Z.; Suveljak, B.; Radolic, V.

    1996-01-01

    The radon concentration in the air and water of the Bizovac spa was measured by the Radhome silicon detector and the average values were obtained as 70 Bq/m 3 in the indoor pool, 40 Bq/m 3 in the hotel room, 135 Bq/m 3 in the closed therapeutic bathroom, but the geothermal water had a Rn concentration of 25.3 kBq/m 3 and the potable one 2.7 kBq/m 3 . The Rn transfer factor (f) from water to air in the indoor pool and therapeutic bathroom was 10 and 40 times higher than for normal dwellings (f n =10 -4 ), respectively. The effective equivalent dose of inhaled radon for permanent personnel under the worst conditions in the spa was 5.4 mSv/y, but visitors spending two weeks in the spa could receive the dose of 77 μSv. (author). 6 refs., 1 fig

  18. Post-neonatal drop in alveolar SP-A expression

    DEFF Research Database (Denmark)

    Stray-Pedersen, Arne; Vege, Ashild; Stray-Pedersen, Asbjorg

    2008-01-01

    BACKGROUND: Surfactant protein A (SP-A) is synthesized in the lung and is a part of the innate immune system. The aim of this study was to evaluate the expression of SP-A in lung tissue from fetuses, infants, children and adults with special regard to sudden infant death syndrome (SIDS). METHODS......: A total of 160 cases were studied; 19 fetuses and neonates, 59 SIDS and 49 explained infant deaths below 1 year of age, 19 toddlers and 14 adults. Immunohistochemical detection of SP-A using monoclonal antibodies was performed by microscopy of lung tissue specimens collected at autopsy. A scoring system...

  19. Translational Science: How experimental research has contributed to the understanding of spontaneous Physical Activity and Energy Homeostasis

    Directory of Open Access Journals (Sweden)

    Izabelle D Benfato

    2017-05-01

    Full Text Available Abstract Spontaneous physical activity (SPA consists of all daily living activities other than volitional exercise (e.g. sports and fitness-related activities. SPA is an important component of energy expenditure and may protect from overweight and obesity. Little is known about the biological regulation of SPA, but animal researchhas contributedsignificantly to expand our knowledge in this field. Studies in rodents have shown that SPA is influenced by nutrients and volitional exercise. High-fat diet seems to decrease SPA, which contributes to weigh gain. Volitional exercisemayalso reduce SPA, helping to explain the commonly reported low efficiency of exercise to cause weight loss, and highlighting the need to finda volume/intensity of exercise to maximize total daily energy expenditure. Animal studieshave also allowed for the identification of some brain areas and chemical mediatorsinvolved in SPA regulation. These discoveries could enable the development of new therapeutics aiming to enhance SPA.

  20. spa typing for epidemiological surveillance of Staphylococcus aureus

    NARCIS (Netherlands)

    Hallin, Marie; Friedrich, Alexander W; Struelens, Marc J; Caugant, Dominique A.

    2009-01-01

    The spa typing method is based on sequencing of the polymorphic X region of the protein A gene (spa), present in all strains of Staphylococcus aureus. The X region is constituted of a variable number of 24-bp repeats flanked by well-conserved regions. This single-locus sequence-based typing method

  1. HOSPITALITY ENGLISH FOR SPA THERAPISTS IN BANYAN TREE HOTELS AND RESORTS

    Directory of Open Access Journals (Sweden)

    Ratnasari Nugraheni

    2018-04-01

    Full Text Available This study is a preliminary study of research and design for hospitality English for SPA therapist in Banyan Tree Hotels and Resorts at Bintan Island. The purpose of this study is to help the English teacher to provide a successful English training since a good English proficiency used in the hospitality industry is obliged, especially for an-international-five-star-hotel-brand. The nature of the study is qualitative using R&D approach. Since this is only a preliminary study, need analysis becomes the primary focus. The data were collected through interview and observation. The participants were people who are working in SPA department in Banyan Tree Bintan, such as SPA trainer, SPA therapist, and SPA manager.

  2. SPA: a probabilistic algorithm for spliced alignment.

    Directory of Open Access Journals (Sweden)

    2006-04-01

    Full Text Available Recent large-scale cDNA sequencing efforts show that elaborate patterns of splice variation are responsible for much of the proteome diversity in higher eukaryotes. To obtain an accurate account of the repertoire of splice variants, and to gain insight into the mechanisms of alternative splicing, it is essential that cDNAs are very accurately mapped to their respective genomes. Currently available algorithms for cDNA-to-genome alignment do not reach the necessary level of accuracy because they use ad hoc scoring models that cannot correctly trade off the likelihoods of various sequencing errors against the probabilities of different gene structures. Here we develop a Bayesian probabilistic approach to cDNA-to-genome alignment. Gene structures are assigned prior probabilities based on the lengths of their introns and exons, and based on the sequences at their splice boundaries. A likelihood model for sequencing errors takes into account the rates at which misincorporation, as well as insertions and deletions of different lengths, occurs during sequencing. The parameters of both the prior and likelihood model can be automatically estimated from a set of cDNAs, thus enabling our method to adapt itself to different organisms and experimental procedures. We implemented our method in a fast cDNA-to-genome alignment program, SPA, and applied it to the FANTOM3 dataset of over 100,000 full-length mouse cDNAs and a dataset of over 20,000 full-length human cDNAs. Comparison with the results of four other mapping programs shows that SPA produces alignments of significantly higher quality. In particular, the quality of the SPA alignments near splice boundaries and SPA's mapping of the 5' and 3' ends of the cDNAs are highly improved, allowing for more accurate identification of transcript starts and ends, and accurate identification of subtle splice variations. Finally, our splice boundary analysis on the human dataset suggests the existence of a novel non

  3. Hypersensitivity pneumonitis with Mycobacterium avium complex among spa workers.

    Science.gov (United States)

    Moraga-McHaley, Stephanie Ann; Landen, Michael; Krapfl, Heidi; Sewell, C Mack

    2013-01-01

    The New Mexico Department of Health (NMDOH) investigated the cause of two cases of hypersensitivity pneumonitis (HP) in spa maintenance workers with laboratory confirmed Mycobacterium avium complex (MAC). The investigation occurred in tandem with worker protection and swimming pool regulatory investigations by the New Mexico Environment Department at the spa where the workers were employed. The investigation was conducted in order to identify unreported cases, exposure source(s), and to prevent further worker exposure. NMDOH surveyed 57 spa employees about symptoms and exposures, categorized jobs according to self-reported exposure to water, and computed odds ratios for symptom reporting by exposure category. Environmental isolates from spa water and filter swabs were cultured and compared to patient isolates by the Environmental and Applied Microbiology Team, Centers for Disease Control and Prevention (CDC). Workers with the highest exposure reported more HP-like symptoms (OR = 9.6), as did intermediate exposure workers (OR = 6.5), compared to workers with no aerosolized water exposure. Two of 13 environmental isolates were closely related to one of the patient isolates. Workers were likely exposed during spray cleaning of cartridge filters in a poorly ventilated work space. Recommendations include inhibiting organism growth in spa systems, assuring the use of respiratory protection, and adequately ventilating work spaces where filters and equipment are cleaned.

  4. Radon measurement in the spa of Bizovac

    International Nuclear Information System (INIS)

    Faj, Z.; Radolic, V.; Suveljak, B.; Planinic, J.

    1996-01-01

    The spa of Bizovac is located 20 km on the west of Osijek in east Croatia. Radon concentrations in the air and water of the Bizovac spa were measured by the Radhome silicon detector and the average values were obtained as 70 Bq/m 3 in the indoor pool, 40 Bq/m 3 in the hotel room and 135 Bq/m 3 in the closed therapeutic bathroom. A special experiment was performed in a closed therapeutic bathroom by three bathtubes filled up with geothermal water as well as normal (potable) one from water-supply. Using measured radon concentrations in air by Radhome detector under the mentioned conditions in the closed bathroom, radon concentrations were assessed for the geothermal water as 25.3 Bq/m 3 and 2.7 Bq/m 3 for potable water. Radon in potable water, measured by the sampling glass ampoule and scintillation cell, had the concentration of 3.5 Bq/m 3 . The radon transfer factor from water to air in the indoor pool and therapeutic bathroom was 10 and 40 times higher than for normal dwelling factor (10 -4 ), respectively. The effective dose equivalent of inhaled radon for permanent personnel under the worst conditions in the spa (closed therapeutic bathroom) was 5.4 mSv/y, but visitors spending two weeks in the Bizovac spa could receive the dose of 77 μSv. (author)

  5. CoSpa: A Co-training Approach for Spam Review Identification with Support Vector Machine

    Directory of Open Access Journals (Sweden)

    Wen Zhang

    2016-03-01

    Full Text Available Spam reviews are increasingly appearing on the Internet to promote sales or defame competitors by misleading consumers with deceptive opinions. This paper proposes a co-training approach called CoSpa (Co-training for Spam review identification to identify spam reviews by two views: one is the lexical terms derived from the textual content of the reviews and the other is the PCFG (Probabilistic Context-Free Grammars rules derived from a deep syntax analysis of the reviews. Using SVM (Support Vector Machine as the base classifier, we develop two strategies, CoSpa-C and CoSpa-U, embedded within the CoSpa approach. The CoSpa-C strategy selects unlabeled reviews classified with the largest confidence to augment the training dataset to retrain the classifier. The CoSpa-U strategy randomly selects unlabeled reviews with a uniform distribution of confidence. Experiments on the spam dataset and the deception dataset demonstrate that both the proposed CoSpa algorithms outperform the traditional SVM with lexical terms and PCFG rules in spam review identification. Moreover, the CoSpa-U strategy outperforms the CoSpa-C strategy when we use the absolute value of decision function of SVM as the confidence.

  6. Diverse modulation of spa transcription by cell wall active antibiotics in Staphylococcus aureus

    DEFF Research Database (Denmark)

    Nielsen, Lene Nørby; Roggenbuck, Michael; Haaber, Jakob Krause

    2012-01-01

    ABSTRACT: BACKGROUND: The aim of this study was to investigate the effect of various classes of clinically relevant antibiotics at sub-lethal concentrations on virulence gene expression and biofilm formation in Staphylococcus aureus. FINDINGS: LacZ promoter fusions of genes related to staphylococ......ABSTRACT: BACKGROUND: The aim of this study was to investigate the effect of various classes of clinically relevant antibiotics at sub-lethal concentrations on virulence gene expression and biofilm formation in Staphylococcus aureus. FINDINGS: LacZ promoter fusions of genes related...... to staphylococcal virulence were used to monitor the effects of antibiotics on gene expression in a disc diffusion assay. The selected genes were hla and spa encoding alpha-hemolysin and Protein A, respectively and RNAIII, the effector molecule of the agr quorum sensing system. The results were confirmed...... by quantitative real-time PCR. Additionally, we monitored the effect of subinhibitory concentrations of antibiotics on the ability of S. aureus to form biofilm in a microtiter plate assay. The results show that sub-lethal antibiotic concentrations diversely modulate expression of RNAIII, hla and spa. Consistently...

  7. Comparing whole-genome sequencing with Sanger sequencing for spa typing of methicillin-resistant Staphylococcus aureus.

    Science.gov (United States)

    Bartels, Mette Damkjær; Petersen, Andreas; Worning, Peder; Nielsen, Jesper Boye; Larner-Svensson, Hanna; Johansen, Helle Krogh; Andersen, Leif Percival; Jarløv, Jens Otto; Boye, Kit; Larsen, Anders Rhod; Westh, Henrik

    2014-12-01

    spa typing of methicillin-resistant Staphylococcus aureus (MRSA) has traditionally been done by PCR amplification and Sanger sequencing of the spa repeat region. At Hvidovre Hospital, Denmark, whole-genome sequencing (WGS) of all MRSA isolates has been performed routinely since January 2013, and an in-house analysis pipeline determines the spa types. Due to national surveillance, all MRSA isolates are sent to Statens Serum Institut, where the spa type is determined by PCR and Sanger sequencing. The purpose of this study was to evaluate the reliability of the spa types obtained by 150-bp paired-end Illumina WGS. MRSA isolates from new MRSA patients in 2013 (n = 699) in the capital region of Denmark were included. We found a 97% agreement between spa types obtained by the two methods. All isolates achieved a spa type by both methods. Nineteen isolates differed in spa types by the two methods, in most cases due to the lack of 24-bp repeats in the whole-genome-sequenced isolates. These related but incorrect spa types should have no consequence in outbreak investigations, since all epidemiologically linked isolates, regardless of spa type, will be included in the single nucleotide polymorphism (SNP) analysis. This will reveal the close relatedness of the spa types. In conclusion, our data show that WGS is a reliable method to determine the spa type of MRSA. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

  8. Rehabilitation of patients with rheumatoid arthritis treated in stationary spa treatment

    Directory of Open Access Journals (Sweden)

    Amila Jaganjac

    2015-04-01

    Full Text Available Introduction: Rheumatic diseases are nonsurgical diseases of the locomotor system and connective tissue. Rheumatoid arthritis (RA is a systemic inflammatory disease of connective tissue of unknown cause, with progressive chronic or subacute course. The aim of the research is to determine whether stationary spa treatment leads to improvement of the functional status in patients with rheumatoid arthritis. Methods: We included 35 patients with diagnosis of rheumatoid arthritis, referred for treatment at the spa " Ilidža " Gradačac from February to April 2014. Patients not adhering to treatment protocols were excluded. We used Visual analogue pain scale (VAS, HAQ questionnaire and assessment of the clinical condition before and after the treatment based on the scores 1-5.Results: There were 32 female and 3 male patients. The average age was 62.28±8.31 years. Based on the HAQ, 12 patients had no difficulties, 9 of them perform activities with little difficulties, 10 with many difficulties, and 4 patients cannot perform certain activities. Before treatment VAS was 6.63±2.36, and after treatment the 2.51±2.27. Ratings of clinical condition before treatment was 2.38±0.74, and after the treatment 3.64±0.98. The most frequently used therapies were kinesitherapy, magnetotherapy and interferential electricity. Conclusions: Stationary treatment at the spa „Ilidža“ Gradačac leads to an improvement of the functional status in patients with rheumatoid arthritis.

  9. SWOT ANALYSIS OF SPA TOURISM IN BULGARIA

    Directory of Open Access Journals (Sweden)

    Aleksandar Davchev

    2016-06-01

    Full Text Available Our time is marked by the increasingly dynamic changing environment. The new conditions in which we operate are characterized by increasing complexity and labor activities that require more responsible behavior. The rising levels of stress and the increasing lack of free time for relaxation and recreation require a new look at the possibilities for the prevention of personal health. The plane of the consumer society in which we live is increasingly shifted by aspiration and vision of an environmentally friendly lifestyle. The focus here is the implementation of a multilevel wellness concept that changes qualitatively the status quo and seeks for ways to harmonize the body with the nature. One of the options is the practice of SPA tourism in whose genesis is the multilayered beneficial impact of a series of procedures and actions. This new alternative through its economic dimensions is an attractive business niche which over time becomes an industry. The current state of the SPA tourism in Bulgaria is controversial despite existing achievements and introduced best practices. Traditions in this direction and the presence of favorable basis for its approval, however, are not sufficient to achieve stability and an upward trend in development. There are existing a number of weaknesses and negative aspects that create frustration in users, which is a real threat to its future. The proposed SWOT-analysis as part of a comprehensive and multilateral study of the state of SPA tourism in Bulgaria reveals some of the existing problems. There have been some suggestions to minimize the impact of weaknesses and eliminate the errors found in leading business organizations managing processes. A detailed analysis and evaluation of the formulated conclusions is ahead, as well as concluding on ideas to improve the state of the sector – a subject of a further investigation by the author.

  10. Elementi koji diferenciraju ugovor o spašavanju od ugovora o tegljenju : (prikaz presude

    Directory of Open Access Journals (Sweden)

    Vesna Skorupan Wolff

    2016-07-01

    Full Text Available Brod kojem su se zaustavili porivni strojevi, a uslijed toga vjetar i morska struja nosili su ga prema obali, zatražio je uslugu tegljenja. Između stranaka je sporno radi li se u konkretnom slučaju o ugovoru o tegljenju ili ugovoru o spašavanju. Spašavanje je svaka djelatnosti kojoj je svrha spašavanje osoba, brodova i stvari s tih brodova. Bitan element pojma spašavanja jest da se osoba, odnosno stvar koja se spašava nalazi u opasnosti (opasnost po život osoba, odnosno propast stvari. Pod spašavanjem se podrazumijeva i pružanje pomoći. Ako je pomoć pružena tegljenjem, to ne znači da se radi o pravnom poslu tegljenja. U konkretnom slučaju u pitanju nije bio komercijalni posao tegljenja već posao spašavanja.

  11. [The topical problems of pediatric balneotherapy and the spa and health resort-based treatment of the children].

    Science.gov (United States)

    Razumov, A N; Khan, M A

    2016-01-01

    This article is devoted to the topical problems of pediatric balneotherapy with special reference to the organization of the spa and health resort-based treatment of the children in the Russian Federation. The main issues discussed by the authors include the current state of health resort care for the children, the problem of statutory regulation of the activities of the children's spa and health resort facilities, the approaches to increasing the availability of the spa and health resort-based treatment for the children at the enhanced risk of the development of chronic diseases, disabilities, and tuberculosis. Also considered are the problems of the development of the regulatory framework for the medical rehabilitation of the children based at the spa and health resort facilities. The principal goals to be sought in climatotherapy, physiotherapy, balneotherapy, and pelotherapy in the pediatric context are outlined along with the further prospects for the development of the main areas of pediatric balneology.

  12. [Effects of drinking spa therapy on oxidative stress].

    Science.gov (United States)

    Costantino, M; Giampaolo, C; Filippelli, A

    2012-01-01

    Data of literature have shown the correlation between oxidative stress and some diseases of gastrointestinal and metabolic relevance such as diabetes mellitus, gastric cancer, gastritis, etc.. Studies have also shown that sulfurous mineral water may be useful in the treatment of gastrointestinal diseases. The aim of our research was to evaluate the antioxidant effect of sulphurous mineral water, administered by drinking method, in type 2 diabetes mellitus, a chronic disease with a high social and economic impact. The study has been performed on 57 subjects (25% women and 75% males; mean age: 60 ± 1.1 years; BMI: 27 ± 0.4) affected by type 2 Diabetes Mellitus. The subjects were divided in four groups: A (subjected to glucose-lowering diet therapy), B (subjected to antihyperglycaemic therapy), C (exposed to glucose-lowering diet therapy + drinking SPA therapy) and D (exposed to antihyperglycaemic therapy + drinking SPA therapy). Drinking SPA treatment was effected with sulphurous mineral water from Terme of Telese SpA (Benevento - Italy) and the pharmacological treatment provided the use of hypoglycemic drugs normally used in diabetic disease. After two weeks of therapy with treatments considered were evaluated fasting blood glycaemia and plasma concentration of ROMs (reactive oxygen metabolites) (d-ROMs test-Diacron International srl®-Grosseto - Italy). The results of our study have shown a significant (pfasting blood glycaemia when to hypoglycemic drugs or diet therapy was associated the sulphurous drinking SPA therapy. It was also observed a reduction of plasma ROMs levels, significant (p water, especially in combination with antidiabetic drug treatment, may be useful in type 2 diabetes mellitus for the improvement redox state of the organism.

  13. Surface expression and functional characterization of recombinant SpaFED pili in Lactococcus lactis

    OpenAIRE

    Rintahaka, Johanna; Yu, Xia; Kant, Ravi; Palva, Airi; von Ossowski, Ingemar

    2014-01-01

    A noticeable genomic feature of many piliated Gram-positive bacterial species is the presence of more than one pilus-encoding operon. Paradigmatically, the gut-adapted Lactobacillus rhamnosus GG strain contains two different fimbrial operons in its genome. However, whereas one of these operons (called spaCBA) is encoding for the functionally mucus-/collagen-binding SpaCBA pilus, for the other operon (called spaFED) any native expression of the SpaFED-called pili is still the subject of some u...

  14. Removal of linear alkylbenzene sulfonate (LAS) and its intermediate, sulfophenylalkanoates (spa) using a bioreactor

    Energy Technology Data Exchange (ETDEWEB)

    Lee, In Ku [Seoul National Univ., Seoul (Korea, Republic of); Kim, Ji Hyeon; Yoo, Young Je [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of); Kim, Hwa Yong [Seoul National Univ., Seoul (Korea, Republic of)

    1995-12-01

    A fluidized-bed bioreactor was used to treat the industrial wastewater containing linear alkylbenzene sulfonate(LAS). Microorganism obtained by acclimation showed low growth rate and substrate inhibition at relatively high substrate concentration. It was found from the experiment using fluidized-bed bioreactor that 64 {mu}m-thick biofilm was made after 15 days. The 93.4% LAS removal efficiency in the reactor was obtained at 120 mg/L of initial LAS concentration, while the removal efficiency of sulfophenylalkannoates(SPA) which is a representative intermediate of biodegradation of LAS was 60-88% depending on the initial concentration of LAS. When sodium benzoate was added to the second reactor, the remaining SPA became lowered by 40% compared to the control experiment. And when activated carbon was added to the reactor, the removal efficiency of SPA was 96.2% and that of LAS was 100% when initial inflowing concentration of LAS was 350 mg/L. 13 refs., 4 tabs., 8 figs.

  15. Non-spa-typeable clinical Staphylococcus aureus strains are naturally occurring protein A mutants

    DEFF Research Database (Denmark)

    Baum, Cathrin; Haslinger-Löffler, Bettina; Westh, Henrik

    2009-01-01

    Staphylococcus aureus is a major human pathogen responsible for increasing the prevalence of community- and hospital-acquired infections. Protein A (SpA) is a key virulence factor of S. aureus and is highly conserved. Sequencing of the variable-number tandem-repeat region of SpA (spa typing) prov...

  16. The Role and Importance of Spa and Wellness Tourism in Hungary's Tourism Industry

    Directory of Open Access Journals (Sweden)

    Csapó János

    2017-06-01

    Full Text Available This paper presents and highlights the role and importance of spa and wellness tourism in Hungary. Ever since tourism has played an important role in the social-economic processes of the country the leading tourism product proved to be health tourism (spa and wellness thanks to the advantageous physical geographical and social-political background. After the presentation of the country-specific theoretical system of spa and wellness, the paper examines the supply and the demand side together with competitor analysis and recent trends in spa and wellness in Hungary.

  17. Spa therapy for elderly: a retrospective study of 239 older patients with osteoarthritis

    Science.gov (United States)

    Karagülle, Mine; Kardeş, Sinan; Dişçi, Rian; Gürdal, Hatice; Karagülle, Müfit Zeki

    2016-10-01

    Very few studies tested the effectiveness of spa therapy in older patients with osteoarthritis. Therefore, we aimed to evaluate the short-term effects of spa therapy in patients aged 65 years and older with generalized, knee, hip, and cervical and lumbar spine osteoarthritis. In an observational retrospective study design at the Medical Ecology and Hydroclimatology Department of Istanbul Medical Faculty, we analyzed the records of 239 patients aged over 65 years with the diagnosis of all types of osteoarthritis who were prescribed a spa therapy course in some spa resorts in Turkey between 7 March 2002 and 31 December 2012. They travelled to a spa resort where they stayed at a thermal spa hotel and followed the usual therapy packages for 2 weeks. Patients were assessed by an experienced physician within a week before the spa journey and within a week after the completion of the spa therapy. Compared with baseline in whole sample, statistically significant improvements were observed in pain (visual analog scale, VAS), patient and physician global assessments (VAS), Health Assessment Questionnaire disability index (HAQ-DI), Lequesne algofunctional index (LAFI) for knee, Western Ontario and McMaster Universities index (WOMAC), Waddell disability index (WDI), and Neck Pain and Disability Scale (NPAD). According to Outcome Measures in Rheumatology—Osteoarthritis Research Society International (OMERACT-OARSI) Set of Responder Criteria, responder rate were 63.8 % (51/80) in generalized, 52 % (13/25) in knee, 50 % (2/4) in hip, 66.7 % (8/12) in lumbar, and 100 % (6/6) in cervical osteoarthritis subgroups. Spa therapy improved pain and physical functional status in older patients with osteoarthritis, especially generalized osteoarthritis and multiple joint osteoarthritis with involvement of knee. This improvement was clinically important in majority of the patients. To confirm the results of this preliminary study, there is a need of a randomized controlled clinical study

  18. [Balneotherapy and spa therapy of rheumatic diseases in Turkey: a systematic review].

    Science.gov (United States)

    Karagülle, M Z; Karagülle, M

    2004-02-01

    Turkey has a lot of thermal and mineral springs and is looking back on a still vivid tradition of spa therapy and balneotherapy, applied especially for the treatment of rheumatic diseases. This tradition is predominantly empiric and intuitive, however, it has assumed some important aspects of modern balneotherapeutic methods as well. This article is aimed at presenting the characteristics of traditional and modern balneological and spa therapy forms in Turkey. The studies which have been conducted between 1990 and 2000 in different spas in Turkey on the efficacy and effectiveness of spa therapy and balneotherapy for rheumatic diseases have been searched and analyzed independent of their design. A descriptive evaluation of the studies was carried out. A total of 15 published studies have been found and analyzed. The investigations have been carried out in 8 different spa resorts in Turkey. In these studies the effectiveness and efficacy of different balneological and spa therapies on a variety of rheumatic diseases (from osteoarthritis to fibromyalgia and from rheumatoid arthritis to low back pain) could be shown. Nearly all studied balneotherapeutic modalities were applied as bathing cures. Only in one study peloid therapy was applied. Balneotherapeutic therapy was applied in a modern and traditional way, and both open and stationary spa therapy forms were used at the same time. The review has shown the effectiveness of the investigated spa therapy and balneotherapy forms. It could be concluded that nearly all forms of spa therapy and balneotherapy used for the treatment of rheumatic diseases in Turkey are effective. A definitive conclusion, however, is not possible because of the heterogeneity of the study designs, methodological flaws, and the publication bias. In future good quality randomized controlled trials are needed. Copyright 2004 S. Karger GmbH, Freiburg

  19. SPA (Solus per Aqua) service industry: An entrepeneurship opportunity to beauty education department

    Science.gov (United States)

    Marwiyah, Apriyani, Delta

    2018-03-01

    Beauty industry grows vastly in the scope of regional, national, or international. Beauty industry includes Spa service. It becomes one of the choices where the urban citizen can use it to release their stress and relax their mind. This business grows as the development of technology. Spa industry should be able to provide the best service for physical and mental therapy, it will make the user of the service can be freed from their business and stress in the respective time to be healthies, more beautiful, and able to do their activity maximally. Spa treatment consists of hair creambath, facial treatment, manicure-pedicure, scrub treatment, foot spa, aromatherapy, and body treatment with traditional cosmetics which are easy to get in Indonesia. Beauty education is one of the programs in Home Economics Department of Engineering Faculty of UNNES. This program was established to produce graduates in beauty fields as Vocational High School teachers with bachelor (S1) qualification. The graduates suppose to be excellent, professional, skillful, and care to the environment, culture, and social condition around them. It prepares them as teachers of beauty (in formal and non- formal education). Besides, it also prepared them to have professional competence in production fields of beauty service with adaptive, creative, and innovative which can be entrepreneurs who are able to create job vacancies for others. Beauty education used KKNI- based curriculum, which is oriented to Industry and Working Fields with UNNES' Conservation basis. It provided the students a chance to practive their knowledge in working internship program, study field trip, and teaching practice program. The industry of Spa service provides a big chance to become an entrepreneur, create a working field, and help the government reduce unemployment number, whether from beauty education graduates or from vocational high school students

  20. Analysis of the radioactivity in the 'Elguea' spa, Villa Clara, Cuba

    International Nuclear Information System (INIS)

    Fernandez G, I.M.; Zerquera, J.T.; Carrazana G, J.; Capote F, E.; Rodriguez C, G.

    2006-01-01

    The 'Elguea' spa, located in the north coast of the county of Villa Clara, Cuba, is considered one of those more important spas of Latin America. The waters of this spa are rich in salts of chlorine, sodium, bromine, sulfides and its contain radon. As a result of measurements of environmental gamma dose rates carried out in the area of the spa, its were considered levels of dose between 0.13 and 2.3 mSv. The obtained results motivated that it was carried out a characterization, from the radiological point of view, of the spa. This characterization is of supreme importance to be able to evaluate the impact that it has and the discharges of its waters on the environment, as well as, those dose that the population potentially affected can receive by these discharges. With this end its were carried out quantitative determinations of those existent natural more significant radionuclides in different environmental objects coming from the area of the spa and its surroundings, as well as one characterization gamma 'in situ' of the same one. The obtained results are present in this work. (Author)

  1. [Nonnius and the Spa cure].

    Science.gov (United States)

    Lecomte, J; Lemli, J; Marganne, M H; Melard, M

    1996-01-01

    The 12th of July 1635, Jan van Beverwyck wrote a letter from Dordrecht to his esteemed friend Luis Nunez, in Antwerp. He asked him for indications about the cure of kidney stones of which he was suffering. He had just passed two calculi very painfully. Nunez answered on July 31. His letter summarized his own experience with this disease. In such cases, temperate diuretics and emollients are well indicated: ingestion of light decoctions of Malva and Viola, Caerefolium and Parieteria as well as Marshmallow syrup. No purge and no 'chemicals'. However, the best remedy was drinking Spa water. Usually the best way to absorb it is to come to the springs, in the Ardennes, part of the independent Principality of Liège. However, considering the horrors of the war (the Thirty Years War) endangering the country, van Beverwyck would be wise to drink imported water during 40 or 50 days, while staying home quietly, in Dordrecht. The letter points out the importance of provoked diuresis in the treatment of kidney stones. On the other hand the letter is an illustration of the continuing contacts between the United Provinces and the Spanish territories and of the commercial traffic between Antwerp, Dordrecht and Spa. The exported water was bottled from many 'pouhons'. It was acid, ferruginous, sulfurous and saturated with carbon dioxide; no pathogen germs, at least at the spring. Nunez quoted the large number of his patients cured with Spa water in Antwerp. This is an illustration of its commercial expansion even during this critical period.

  2. The spa typing of methicillin-resistant Staphylococcus aureus isolates by High Resolution Melting (HRM) analysis.

    Science.gov (United States)

    Fasihi, Yasser; Fooladi, Saba; Mohammadi, Mohammad Ali; Emaneini, Mohammad; Kalantar-Neyestanaki, Davood

    2017-09-06

    Molecular typing is an important tool for control and prevention of infection. A suitable molecular typing method for epidemiological investigation must be easy to perform, highly reproducible, inexpensive, rapid and easy to interpret. In this study, two molecular typing methods including the conventional PCR-sequencing method and high resolution melting (HRM) analysis were used for staphylococcal protein A (spa) typing of 30 Methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered from clinical samples. Based on PCR-sequencing method results, 16 different spa types were identified among the 30 MRSA isolates. Among the 16 different spa types, 14 spa types separated by HRM method. Two spa types including t4718 and t2894 were not separated from each other. According to our results, spa typing based on HRM analysis method is very rapid, easy to perform and cost-effective, but this method must be standardized for different regions, spa types, and real-time machinery.

  3. Treatment with mPEG-SPA improves the survival of corneal grafts in rats by immune camouflage.

    Science.gov (United States)

    Wang, Shuangyong; Li, Liangliang; Liu, Ying; Li, Chaoyang; Zhang, Min; Wang, Bowen; Huang, Zheqian; Gao, Xinbo; Wang, Zhichong

    2015-03-01

    We investigated the immune camouflage effects of methoxy polyethylene glycol succinimidyl propionate (mPEG-SPA) on corneal antigens and explored a novel approach for reducing corneal antigenicity, thereby decreasing corneal graft rejection. Importantly, this approach did not alter normal local immunity. Corneal grafts were treated with mPEG-SPA 5KD or 20KD (3% W/V), which could shield major histocompatibility antigen class I molecules (RT1-A) of corneal grafts. Skin grafts of Wistar rats were transplanted to SD rats. Then the splenic lymphocytes were isolated from SD rats. Subsequently, the lymphocytes were co-cultured with autologous corneal grafts or untreated corneal grafts and PEGylated grafts treated with mPEG-SPA 5KD or 20KD obtained from the counterpart skin donors, which were used as autologous control, allogeneic control, mPEG-SPA 5KD group and mPEG-SPA 20KD group, respectively. Lymphocyte proliferation was lower in mPEG-SPA 5KD group and mPEG-SPA 20KD group than in the allogeneic control. SD rats with corneal neovascularisation were used as recipients for high-risk corneal transplantation and were randomly divided into four groups: autologous control, allogeneic control, mPEG-SPA 5KD group and mPEG-SPA 20KD group. The recipients received corneal grafts from Wistar rats. Corneal graft survival was prolonged and graft rejection was reduced in the mPEG-SPA 5KD group and the mPEG-SPA 20KD group compared to the allogeneic control. Thus, we think that mPEG-SPA could immunologically camouflage corneal antigens to prolong corneal grafts survival in high-risk transplantation. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. Positive and cost-effectiveness effect of spa therapy on the resumption of occupational and non-occupational activities in women in breast cancer remission: a French multicentre randomised controlled trial.

    Science.gov (United States)

    Mourgues, Charline; Gerbaud, Laurent; Leger, Stéphanie; Auclair, Candy; Peyrol, Fleur; Blanquet, Marie; Kwiatkowski, Fabrice; Leger-Enreille, Anne; Bignon, Yves-Jean

    2014-10-01

    The main aim was to assess the effects of a spa treatment on the resumption of occupational and non-occupational activities and the abilities of women in breast cancer remission. A cost-effectiveness analysis (CEA) was also performed. A multicentre randomised controlled trial was carried out between 2008 and 2010 in the University Hospital of Auvergne and two private hospitals in Clermont-Ferrand, France. Eligible patients were women in complete breast cancer remission without contraindication for physical activities or cognitive disorders and a body mass index between 18.5 and 40 kg/m(2). The intervention group underwent spa treatment combined with consultation with dietician whereas the control underwent consultations with the dietician only. Of the 181 patients randomised, 92 and 89 were included in the intervention and the control groups, respectively. The CEA involved 90 patients, 42 from the intervention group and 48 from the control group. The main results showed a higher rate of resumption of occupational activities in the intervention group (p = 0.0025) and a positive effect of the intervention on the women's ability to perform occupational activities 12 months after the beginning of the study (p = 0.0014), and on their ability to perform family activities (p = 0.033). The stay in a thermal centre was cost-effective at 12 months. Spa treatment is a cost-effective strategy to improve resumption of occupational and non-occupational activities and the abilities of women in breast cancer remission. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. The impact of spa treatment on quality of life of elderly people

    Directory of Open Access Journals (Sweden)

    Marta Wardeńska

    2017-02-01

    Full Text Available The aim of this study was to assess the impact of the spa treatment on the quality of life of the older people. The study included 18 women and 22 men over 60 years of age. Method used was diagnostic survey - a questionnaire containing closed and open questions, on the subjective assessment of their own quality of life, as well as spa treatment and its impact on health and well-being. This study lead to a conclusion that due the spa treatment, the quality of life of patients over 60 ages expressed their subjective assessment improves. This confirms the hypothesis that older people using spa treatment are characterized by a significantly higher level of quality of life.

  6. Spa therapy in the treatment of knee osteoarthritis: a large randomised multicentre trial

    Science.gov (United States)

    Forestier, R; Desfour, H; Tessier, J-M; Françon, A; Foote, A M; Genty, C; Rolland, C; Roques, C-F; Bosson, J-L

    2010-01-01

    Objective To determine whether spa therapy, plus home exercises and usual medical treatment provides any benefit over exercises and usual treatment, in the management of knee osteoarthritis. Methods Large multicentre randomised prospective clinical trial of patients with knee osteoarthritis according to the American College of Rheumatology criteria, attending French spa resorts as outpatients between June 2006 and April 2007. Zelen randomisation was used so patients were ignorant of the other group and spa personnel were not told which patients were participating. The main endpoint criteria were patient self-assessed. All patients continued usual treatments and performed daily standardised home exercises. The spa therapy group also received 18 days of spa therapy (massages, showers, mud and pool sessions). Main Endpoint The number of patients achieving minimal clinically important improvement (MCII) at 6 months, defined as ≥19.9 mm on the visual analogue pain scale and/or ≥9.1 points in a normalised Western Ontario and McMaster Universities osteoarthritis index function score and no knee surgery. Results The intention to treat analysis included 187 controls and 195 spa therapy patients. At 6 months, 99/195 (50.8%) spa group patients had MCII and 68/187 (36.4%) controls (χ2=8.05; df=1; p=0.005). However, no improvement in quality of life (Short Form 36) or patient acceptable symptom state was observed at 6 months. Conclusion For patients with knee osteoarthritis a 3-week course of spa therapy together with home exercises and usual pharmacological treatments offers benefit after 6 months compared with exercises and usual treatment alone, and is well tolerated. Trial registration number NCT00348777. PMID:19734131

  7. The paradigm of territoriality in the spa tourism: The concept of spatial indicators

    Directory of Open Access Journals (Sweden)

    Dželebdžić Omiljena

    2010-01-01

    Full Text Available The famous tradition of spa places like cultural centers and health resorts with unique potential in natural curing springs could be a solid, but not an adequate, ground for their development according to the challenges of contemporary society. The renewed interest in the territorial aspects of tourism as a response to globalization enhanced the influence of spatial factor (tourismscape on current on tourism demand. The network of flows, relationships and interactions, as the core of the territoriality concept, is not something new and unknown in regional planning but requires a new analytical tool for researching the global network connectivity. This paper analyzes the concept of territorial networking in the system of physical, functional and organizational networks as one of the crucial aspects in the development of well balanced tourism region. The consideration aim is to examine and define the relevant indicators that may specify the level of competitiveness of spa region in the global tourism market.

  8. Spa therapy: can be a valid option for treating knee osteoarthritis?

    Science.gov (United States)

    Tenti, Sara; Cheleschi, Sara; Galeazzi, Mauro; Fioravanti, Antonella

    2015-08-01

    Osteoarthritis (OA) continues to be one of the leading causes of `years lived with disability' worldwide. Symptomatic knee OA is highly prevalent among people aged 50 years and over and is destined to become an ever more important healthcare problem. Current management of knee OA includes non-pharmacological and pharmacological treatments. Spa therapy is one of the most commonly used non-pharmacological approaches for OA in many European countries, as well as in Japan and Israel. Despite its long history and popularity, spa treatment is still the subject of debate and its role in modern medicine continues to be unclear. The objective of this review is to summarize the currently available information on clinical effects and mechanisms of action of spa therapy in knee OA. Various randomized controlled clinical trials (RCTs) were conducted to assess the efficacy and tolerability of balneotherapy and mud-pack therapy in patients with knee OA. Data from these clinical trials support a beneficial effect of spa therapy on pain, function and quality of life in knee OA that lasts over time, until 6-9 months after the treatment. The mechanisms by which immersion in mineral or thermal water or the application of mud alleviate suffering in OA are not fully understood. The net benefit is probably the result of a combination of factors, among which the mechanical, thermal and chemical effects are most prominent. In conclusion, spa therapy seems to have a role in the treatment of knee OA. Additional RCTs and further studies of mechanisms of action with high methodological quality are necessary to prove the effects of spa therapy.

  9. Surfactant protein A (SP-A) inhibits agglomeration and macrophage uptake of toxic amine modified nanoparticles.

    Science.gov (United States)

    McKenzie, Zofi; Kendall, Michaela; Mackay, Rose-Marie; Whitwell, Harry; Elgy, Christine; Ding, Ping; Mahajan, Sumeet; Morgan, Cliff; Griffiths, Mark; Clark, Howard; Madsen, Jens

    2015-01-01

    The lung provides the main route for nanomaterial exposure. Surfactant protein A (SP-A) is an important respiratory innate immune molecule with the ability to bind or opsonise pathogens to enhance phagocytic removal from the airways. We hypothesised that SP-A, like surfactant protein D, may interact with inhaled nanoparticulates, and that this interaction will be affected by nanoparticle (NP) surface characteristics. In this study, we characterise the interaction of SP-A with unmodified (U-PS) and amine-modified (A-PS) polystyrene particles of varying size and zeta potential using dynamic light scatter analysis. SP-A associated with both 100 nm U-PS and A-PS in a calcium-independent manner. SP-A induced significant calcium-dependent agglomeration of 100 nm U-PS NPs but resulted in calcium-independent inhibition of A-PS self agglomeration. SP-A enhanced uptake of 100 nm U-PS into macrophage-like RAW264.7 cells in a dose-dependent manner but in contrast inhibited A-PS uptake. Reduced association of A-PS particles in RAW264.7 cells following pre-incubation of SP-A was also observed with coherent anti-Stokes Raman spectroscopy. Consistent with these findings, alveolar macrophages (AMs) from SP-A(-/-) mice were more efficient at uptake of 100 nm A-PS compared with wild type C57Bl/6 macrophages. No difference in uptake was observed with 500 nm U-PS or A-PS particles. Pre-incubation with SP-A resulted in a significant decrease in uptake of 100 nm A-PS in macrophages isolated from both groups of mice. In contrast, increased uptake by AMs of U-PS was observed after pre-incubation with SP-A. Thus we have demonstrated that SP-A promotes uptake of non-toxic U-PS particles but inhibits the clearance of potentially toxic A-PS particles by blocking uptake into macrophages.

  10. Spa Treatment (Balneotherapy) for Fibromyalgia—A Qualitative-Narrative Review and a Historical Perspective

    Science.gov (United States)

    Ablin, Jacob N.; Buskila, Dan

    2013-01-01

    Aim. To perform a narrative review of spa therapy for management of the fibromyalgia syndrome (FMS), evaluating this traditional time-honored form of therapy in a historical perspective. Methods. Medline was searched using the terms “Spa therapy,” “Balneotherapy,” and “Fibromyalgia” between 1990 (year of ACR fibromyalgia criteria publication) and April 2013. The Cochrane database was also searched. Publications relating to the implementation of spa therapy and related practices over the centuries were identified through references, searched, and reviewed. Results. Reports of balneotherapy were described from diverse locations throughout Europe and Asia, and various forms of water-related therapy have been incorporated for many musculoskeletal indications. In the management of FMS, spa therapy has generally been shown to be well accepted and moderately effective for symptom reduction. Conclusion. While achieving high-quality evidence-based conclusions is difficult for complex natural therapies such as spa therapy, the existing evidence indicates a positive effect in management of FMS. In view of the long history of this modality in the management of rheumatic pain as well as the inherent difficulties related to pharmacological treatment, the role of spa therapy should currently be recognized as part of a therapeutic program for FMS. PMID:23983795

  11. Spa Treatment (Balneotherapy for Fibromyalgia—A Qualitative-Narrative Review and a Historical Perspective

    Directory of Open Access Journals (Sweden)

    Jacob N. Ablin

    2013-01-01

    Full Text Available Aim. To perform a narrative review of spa therapy for management of the fibromyalgia syndrome (FMS, evaluating this traditional time-honored form of therapy in a historical perspective. Methods. Medline was searched using the terms “Spa therapy,” “Balneotherapy,” and “Fibromyalgia” between 1990 (year of ACR fibromyalgia criteria publication and April 2013. The Cochrane database was also searched. Publications relating to the implementation of spa therapy and related practices over the centuries were identified through references, searched, and reviewed. Results. Reports of balneotherapy were described from diverse locations throughout Europe and Asia, and various forms of water-related therapy have been incorporated for many musculoskeletal indications. In the management of FMS, spa therapy has generally been shown to be well accepted and moderately effective for symptom reduction. Conclusion. While achieving high-quality evidence-based conclusions is difficult for complex natural therapies such as spa therapy, the existing evidence indicates a positive effect in management of FMS. In view of the long history of this modality in the management of rheumatic pain as well as the inherent difficulties related to pharmacological treatment, the role of spa therapy should currently be recognized as part of a therapeutic program for FMS.

  12. Role of surfactant protein A (SP-A)/lipid interactions for SP-A functions in the lung.

    Science.gov (United States)

    Casals, C

    2001-01-01

    Surfactant protein A (SP-A), an oligomeric glycoprotein, is a member of a group of proteins named collectins that contain collagen-like and Ca(2+)-dependent carbohydrate recognition domains. SP-A interacts with a broad range of amphipathic lipids (glycerophospholipids, sphingophospholipids, glycosphingolipids, lipid A, and lipoglycans) that are present in surfactant or microbial membranes. This review summarizes SP-A/lipid interaction studies regarding the lipid system used (i.e., phospholipid vesicles, phospholipid monolayers, and lipids immobilized on silica or adsorbed on a solid support). The effect of calcium, ionic strength, and pH on the binding of SP-A to lipids and the subsequent lipid aggregation process is discussed. Current evidence suggests that hydrophobic-binding forces are involved in the peripherical association of SP-A to membranes. It is also proposed that fluid and liquid-ordered phase coexistence in surfactant membranes might favor partition of SP-A into those membranes. The binding of SP-A to surfactant membranes containing hydrophobic surfactant peptides makes possible the formation of a membrane reservoir in the alveolar fluid that is protected by SP-A against inactivation and improves the rate of surfactant film formation. In addition, the interaction of SP-A with membranes might enhance the affinity of SP-A for terminal carbohydrates of glycolipids or glycoproteins on the surface of invading microorganisms.

  13. Description of the behavior of an aquifer by using continuous radon monitoring in a thermal spa

    Energy Technology Data Exchange (ETDEWEB)

    Sainz, Carlos, E-mail: sainzc@unican.es; Rábago, Daniel; Fuente, Ismael; Celaya, Santiago; Quindós, Luis Santiago

    2016-02-01

    Radon ({sup 222}Rn) levels in air and water have been analyzed continuously for almost a year in Las Caldas de Besaya thermal spa, north Spain. Radon is a naturally occurring noble gas from the decay of radium ({sup 226}Ra) both constituents of radioactive uranium 238 series. It has been recognized as a lung carcinogen by the World Health Organization (WHO) and International Agency for Research on Cancer (IARC). Furthermore the Royal Decree R.D 1439/2010 of November, 2010 establishes the obligation to study occupational activities where workers and, where appropriate, members of the public are exposed to inhalation of radon in workplaces such as spas. Together with radon measures several physico-chemical parameters were obtained such as pH, redox potential, electrical conductivity and air and water temperature. The devices used for the study of the temporal evolution of radon concentration have been the RTM 2100, the Radon Scout and gamma spectrometry was complementarily used to determine the transfer factor of the silicone tubes in the experimental device. Radon concentrations obtained in water and air of the spa are high, with an average of 660 Bq/l and 2900 Bq/m{sup 3} respectively, where water is the main source of radon in the air. Radiation dose for workers and public was estimated from these levels of radon. The data showed that the thermal processes can control the behavior of radon which can be also influenced by various physical and chemical parameters such as pH and redox potential. - Highlights: • Radon in water is the major source of indoor air radon concentration in thermal facilities. • Radon in water has been used to characterize the origin of water used for treatments in a spa. • Preliminary dose assessment from radon exposure has been performed.

  14. Description of the behavior of an aquifer by using continuous radon monitoring in a thermal spa

    International Nuclear Information System (INIS)

    Sainz, Carlos; Rábago, Daniel; Fuente, Ismael; Celaya, Santiago; Quindós, Luis Santiago

    2016-01-01

    Radon ( 222 Rn) levels in air and water have been analyzed continuously for almost a year in Las Caldas de Besaya thermal spa, north Spain. Radon is a naturally occurring noble gas from the decay of radium ( 226 Ra) both constituents of radioactive uranium 238 series. It has been recognized as a lung carcinogen by the World Health Organization (WHO) and International Agency for Research on Cancer (IARC). Furthermore the Royal Decree R.D 1439/2010 of November, 2010 establishes the obligation to study occupational activities where workers and, where appropriate, members of the public are exposed to inhalation of radon in workplaces such as spas. Together with radon measures several physico-chemical parameters were obtained such as pH, redox potential, electrical conductivity and air and water temperature. The devices used for the study of the temporal evolution of radon concentration have been the RTM 2100, the Radon Scout and gamma spectrometry was complementarily used to determine the transfer factor of the silicone tubes in the experimental device. Radon concentrations obtained in water and air of the spa are high, with an average of 660 Bq/l and 2900 Bq/m 3 respectively, where water is the main source of radon in the air. Radiation dose for workers and public was estimated from these levels of radon. The data showed that the thermal processes can control the behavior of radon which can be also influenced by various physical and chemical parameters such as pH and redox potential. - Highlights: • Radon in water is the major source of indoor air radon concentration in thermal facilities. • Radon in water has been used to characterize the origin of water used for treatments in a spa. • Preliminary dose assessment from radon exposure has been performed.

  15. [Efficiency of medical and economic activities of a sanatorium-and-spa facility in the active phase of the public health system reform under macroeconomic instability].

    Science.gov (United States)

    Poliakov, B A; Kizeev, M V

    2010-01-01

    Results of a comprehensive study have demonstrated that the reform of the public health system currently underway in this country provides conditions for the extension of medical care based at sanatorium-and-spa facilities with simultaneous rise in relevant expenses. Bearing in mind the unstable macroeconomic situation, this requires thorough monitoring medical and economic activities of health resorts for the purpose of enhancing cost efficiency. The goal of optimization can be achieved by increasing competitive capacity based on strict control of expenditures and income redistribution for financing the most promising projects.

  16. Radioactivity of water and air in Misasa Spa, Japan

    International Nuclear Information System (INIS)

    Morinaga, H.; Mifune, M.; Furuno, K.

    1984-01-01

    Misasa Spa is one of the most highly radioactive hot springs in Japan, the waters of which contain mainly 222 Rn (437 +- 132 Bq.litre -1 ). Radon contents of indoor air of private houses and health resort hotels (built of wood) at Misasa Spa range from 18.5 to 55.5 mBq.litre -1 and 22.2 to 129.5 mBq.litre -1 , respectively. Radon contents in the air of facilities using spring waters at Misasa Branch Hospital of Okayama University were measured to be: bathroom 807 +- 78 mBq.1 -1 , Hubbard-tank bathroom, 5306 +- 2568 mBq.litre -1 ; the drinking hall, 1491 +- 178 mBq.litre -1 . The environmental and dose rate inside private houses has been measured to be 14.0 +- 1.8 μR.h -1 . Chromosome abberations (dicentrics) in the peripheral blood lymphocytes of residents of Misasa Spa were investigated in 14 persons; the mean value of aberration frequencies were 0.21%. (author)

  17. Radioactivity and chromosome aberrations of residents of Misasa Spa

    International Nuclear Information System (INIS)

    Morinaga, Hiroshi; Mifune, Masaaki; Furuno, Katsushi

    1985-01-01

    Misasa Spa is one of the most highly radioactive hot springs in Japan, the waters of which contain mainly 222 Rn (437 ± 132 Bq/liter). Radon contents of indoor air of private houses and health resort hotels (built of wood) at Misasa Spa range from 18.5 to 55.5 mBq/liter and 22.2 to 129.5 mBq/liter, respectively. Radon contents in the air of facilities using spring waters at Misasa Branch Hospital of Okayama University were measured to be; bathroom 807 ± 78 mBq/liter; Hubbardtank bathroom 5306 ± 2568 mBq/liter; the drinking hall 1491 ± 178 mBq/liter. The environmental and dose rate inside private house's has been measured to be 14.0 ± 1.8 μR/h. Chromosome aberrations (dicentrics) in the peripheral blood lymphocytes of residents of Misasa Spa were investigated in 14 persons; the mean value of aberration frequencies were 0.21 %. (Kubozono, M.)

  18. Variations in spa types found in consecutive MRSA isolates from the same patients

    DEFF Research Database (Denmark)

    Boye, Kit; Westh, Henrik

    2010-01-01

    Very little is known about how the spa gene mutates over time in methicillin-resistant Staphylococcus aureus (MRSA) from the same patient. Copenhagen is an area with low prevalence of MRSA but with high variability in spa types. We collected 1536 MRSA isolates from 319 patients during a 5-year...... period and found spa type alterations in 30 MRSA isolates (2%) from 13 patients (4%). The alteration most often seen was the deletion of repeats followed by repeat duplication and point mutation....

  19. Dual Stimuli-Responsive P(NIPAAm-co-SPA Copolymers: Synthesis and Response in Solution and in Films

    Directory of Open Access Journals (Sweden)

    Oliver Grimm

    2018-06-01

    Full Text Available We present the synthesis and solution properties of dual stimuli-responsive poly(N-isopropylacrylamide-co-spiropyran acrylate (P(NIPAAm-co-SPA copolymers of varying composition prepared via nitroxide-mediated copolymerization. The resulting copolymers feature molar masses from 40,000 to 100,000 g/mol according to static light scattering and an SPA content of up to 5.3%. The latter was determined by 1H NMR spectroscopy and UV–Vis spectroscopy. These materials exhibit reversible response upon irradiation in polymeric films for a minimum of three cycles; their response in solution to both light and temperature was also investigated in an aqueous TRIS buffer (pH 8. Irradiation was carried out using LED setups with wavelengths of 365 and 590 nm. In aqueous solution, a custom-made setup using a fiber-coupled 200 W Hg(Xe lamp with 340 and 540 nm filters was used and additional heating of the copolymer solutions during irradiation allowed to study influence of the presence of either the spiropyran or merocyanine form on the cloud point temperature. Hereby, it was found that increasing the SPA content leads to a more pronounced difference between both states and decreasing cloud points in general.

  20. A pilot study to evaluate the effects of floatation spa treatment on patients with osteoarthritis.

    Science.gov (United States)

    Hill, S; Eckett, M J; Paterson, C; Harkness, E F

    1999-12-01

    To conduct a preliminary investigation of the effects on floatation spa therapy on quality of life in patients with osteoarthritis to see if controlled trials are warranted. Uncontrolled clinical trial. Private floatation spa therapy centre. Fourteen patients with chronic osteoarthritis of the weight-bearing joints, of whom four dropped out. Six weekly sessions of floatation spa therapy. SF36, AIMS2 and MYMOP quality-of-life questionnaires. All patients improved. Differences between baseline and discharge scores showed statistically significant improvement for MYMOP, but not AIMS2 or SF-36. Controlled trials of floatation spa therapy for patients with osteoarthritis are warranted.

  1. Pürovel Spa & Sport / Ülli Plink

    Index Scriptorium Estoniae

    Plink, Ülli, 1973-

    2011-01-01

    Swissôtel Tallinna 11. korrusel asuvast Pürovel Spa & Sport poolt pakutavatest treeningutest ning lõõgastusprotseduuridest, samuti 8. korrusel asuvast a la carte menüü ja päevabuffega restoranist Café Swiss

  2. [Spa-based water procedures and complications in the course of their performance].

    Science.gov (United States)

    Persiianova-Dubrova, A L; Badalov, N G; L'vova, N V; Krikorova, S A; Tupitsyna, Iu Iu; Uianaeva, A I; Barashkov, G N; Povazhnaia, E L

    2010-01-01

    The scope of applications of spa-based water procedures have become considerably extended during the recent years; accordingly, the frequency of complications and accidents has increased. The present review considers the possible mechanisms underlying such complications and various factors promoting their development, such as the patients' age and chronic diseases, the use of pharmaceutical products affecting thermoregulation and cardiovascular function. Special attention is given to the influence of alcohol consumption on the frequency of complications, accidents, and sudden death associated with hyperthermal procedures, the possibility of infectious diseases and measures necessary for their prevention.

  3. Role of spontaneous physical activity in prediction of susceptibility to activity based anorexia in male and female rats.

    Science.gov (United States)

    Perez-Leighton, Claudio E; Grace, Martha; Billington, Charles J; Kotz, Catherine M

    2014-08-01

    Anorexia nervosa (AN) is a chronic eating disorder affecting females and males, defined by body weight loss, higher physical activity levels and restricted food intake. Currently, the commonalities and differences between genders in etiology of AN are not well understood. Animal models of AN, such as activity-based anorexia (ABA), can be helpful in identifying factors determining individual susceptibility to AN. In ABA, rodents are given an access to a running wheel while food restricted, resulting in paradoxical increased physical activity levels and weight loss. Recent studies suggest that different behavioral traits, including voluntary exercise, can predict individual weight loss in ABA. A higher inherent drive for movement may promote development and severity of AN, but this hypothesis remains untested. In rodents and humans, drive for movement is defined as spontaneous physical activity (SPA), which is time spent in low-intensity, non-volitional movements. In this paper, we show that a profile of body weight history and behavioral traits, including SPA, can predict individual weight loss caused by ABA in male and female rats with high accuracy. Analysis of the influence of SPA on ABA susceptibility in males and females rats suggests that either high or low levels of SPA increase the probability of high weight loss in ABA, but with larger effects in males compared to females. These results suggest that the same behavioral profile can identify individuals at-risk of AN for both male and female populations and that SPA has predictive value for susceptibility to AN. Copyright © 2014 Elsevier Inc. All rights reserved.

  4. From sulphur to perfume: spa and SPA at Monchique, Algarve.

    Science.gov (United States)

    Bastos, Cristiana

    2011-04-01

    In the thermal village of Monchique, Algarve, different streams of water-related knowledge and practices coexisted for centuries. Those waters were traditionally known as aguas santas (holy waters) and believed to have redemptive healing powers. In the seventeenth century, the Catholic church took control of the place, refashioned the bathing rituals, developed infrastructures and provided assistance to the patients, granting free treatment to the poor. In the nineteenth century, the state replaced the church and imposed that treatments should be provided by professionals trained in the scientific principles of medical hydrology. Secular and scientific as they were, clinical logbooks still allowed for the account of patients that embodied miracle-like redemptive cures 'at the third bath'. People went to Monchique both for its magic and its medicine, bringing in the body ailments achieved in their lives of hard labour. They also went there for a socialising break while healing. From mendicants to rich landowners, coming mostly from the Algarve and neighbouring Alentejo, they crowded the place in summertime. In the twentieth century, as in other places in continental Europe, the spa evolved into a highly medicalised place that qualified for medical expenses reimbursements, which implied the eclipsing--at least from representation--of its leisure component. In the twenty-first century, a new trend of consumer-centred, market-based, post-water balneology with an emphasis on wellness and leisure reinvented the spa as place for lush and diversified consumption. This article argues that the seemingly contradictory systems (markets and medicine) coexist much in the same way that magic, religion and medicine coexisted in the old water sites. The new SPAs, rather than putting an end to the old spas, have enabled them to survive by reinventing thermal sites as places of attraction and leisure.

  5. 77 FR 35888 - Airworthiness Directives; PIAGGIO AERO INDUSTRIES S.p.A Airplanes

    Science.gov (United States)

    2012-06-15

    ...., Washington, DC 20590, between 9 a.m. and 5 p.m., Monday through Friday, except Federal holidays. For service.... Relevant Service Information PIAGGIO AERO INDUSTRIES S.p.A. has issued Service Bulletin No. 80- 0318, dated... Instructions of Piaggio Aero Industries S.p.A. Mandatory Service Bulletin No. 80-0318, revision 2, dated March...

  6. 'MRI-tis' in the early diagnosis of axial SpA: issues and limitations

    NARCIS (Netherlands)

    de Rycke, Leen; Maas, Mario; Tak, Paul P.; Baeten, Dominique

    2010-01-01

    Sacroiliitis on conventional radiography, a key diagnostic feature of axial spondyloarthritis (SpA), often appears only late in the disease course. With the introduction of potent biologic agents that may also be effective in early disease, diagnostic techniques that can identify SpA early in the

  7. [The development of the medical information system for the improvement of the quality of work of the Crimean spa and health resorts].

    Science.gov (United States)

    Ezhov, V V; Grigor'ev, P E; Mizin, V I; Andriiashek, Iu I; Gol'dberg, D L; Olenchuk, A V

    2016-01-01

    The Crimea has the enormous potential for the health promotion activities. However, neither the profile of these activities nor the demand for the socio-medical services is clearly defined for the majority of the local spa and health resort facilities. The possibilities of modern information technology are not used in the full measure either. The objective of the present work was to elaborate the new medical information system and demonstrate its effectiveness. In addition, the article describes the main advantages of the system for the optimization of healthcare in the Crimean spa and health resort facilities. We reviewed and analyzed various literature publications, legal framework, standards, regulations, guidelines, and questionnaire survey data obtain at 50 spa and health resort facilities of the Crimea. The results of the assessment indicate the necessity of the systematic approach to the analysis of the quality of medical care and the process of its further development. Statistical and mathematical methods were used to elaborate the medical information system for the optimization of the activities of the Crimean spa and health resorts. The distinctive features of the proposed information system are modularity and the possibility of flexible adjustment to the conditions of individual settings, one-step data loading with the subsequent multiple application for the formulation of documents, automated filling of records in compliance with the medical standards, and taking into consideration the possible changes in or amendments to the form of the documents. The data obtained in the course of project implementation were used for the first time in the Republic of Crimea to design, substantiate, and recommend for the practical application the algorithm for the comprehensive estimation of the results of treatment of the patients based at the spa and health resort facilities with due regard for the specific regional conditions.

  8. Streptococcus mutans SpaP binds to RadD of Fusobacterium nucleatum ssp. polymorphum.

    Science.gov (United States)

    Guo, Lihong; Shokeen, Bhumika; He, Xuesong; Shi, Wenyuan; Lux, Renate

    2017-10-01

    Adhesin-mediated bacterial interspecies interactions are important elements in oral biofilm formation. They often occur on a species-specific level, which could determine health or disease association of a biofilm community. Among the key players involved in these processes are the ubiquitous fusobacteria that have been recognized for their ability to interact with numerous different binding partners. Fusobacterial interactions with Streptococcus mutans, an important oral cariogenic pathogen, have previously been described but most studies focused on binding to non-mutans streptococci and specific cognate adhesin pairs remain to be identified. Here, we demonstrated differential binding of oral fusobacteria to S. mutans. Screening of existing mutant derivatives indicated SpaP as the major S. mutans adhesin specific for binding to Fusobacterium nucleatum ssp. polymorphum but none of the other oral fusobacteria tested. We inactivated RadD, a known adhesin of F. nucleatum ssp. nucleatum for interaction with a number of gram-positive species, in F. nucleatum ssp. polymorphum and used a Lactococcus lactis heterologous SpaP expression system to demonstrate SpaP interaction with RadD of F. nucleatum ssp. polymorphum. This is a novel function for SpaP, which has mainly been characterized as an adhesin for binding to host proteins including salivary glycoproteins. In conclusion, we describe an additional role for SpaP as adhesin in interspecies adherence with RadD-SpaP as the interacting adhesin pair for binding between S. mutans and F. nucleatum ssp. polymorphum. Furthermore, S. mutans attachment to oral fusobacteria appears to involve species- and subspecies-dependent adhesin interactions. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  9. Co-brand strategy of evaluation of visual images in furniture design: Jimmy S.P.A. and STRAUSS as examples

    Science.gov (United States)

    Chen, Tien-Li; Pan, Fang-Ming; Tsai, Jen-Hui

    2013-03-01

    This study aimed to investigate the correlation of the image associated by the design Co-Brand (Jimmy S.P.A. and STRAUSS) and the impression perceived by subject of viewers. Visual images were used to examine the merit of the evaluation. The best result is provided using an object as an appropriate evaluation method. There are a lot of factors which influence to evaluation of a design. This study is limited to distinguish the appearance from Jimmy's picture books transform furniture and so on. Co-Brand of Jimmy S.P.A. and STRAUSS is not easy because there are not from the same cultural, and industry background and applying different marketing strategy, it is a way to combine the two brands by designing, used questionnaire of SD (Semantic differential evaluation) evaluation method to test out the perception of viewers, the objective of this study is to investigate and appraised the Co-Brands use by of the image in furniture from patrons. SD evaluation result showed, if design cannot understand the perception image of Jimmy S.P.A and STRAUSS with viewers mind, furniture design also can't transmit feeling with design.

  10. Fibromyalgia Syndrome and Spa Therapy: Myth or Reality?

    Directory of Open Access Journals (Sweden)

    Giacomo M. Guidelli

    2012-01-01

    Full Text Available Fibromyalgia syndrome (FS is a common musculoskeletal disorder characterized by otherwise unexplained chronic widespread pain, a lowered pain threshold, high tender point counts, sleep disturbances, fatigue, headache, irritable bowel syndrome, morning stiffness, paraesthesias in the extremities, often psychological distress and depressed mood. Consequently, FS has a negative impact on working capacity, family life, social functioning and quality of life. Because of unknown etiology and not clearly understood pathogenesis, there is no standard therapy regime for FS. A variety of medical treatments, including antidepressants, opioids, analgesic or non-steroidal anti-inflammatory drugs, sedatives, muscle relaxants and antiepileptics, have been used to treat FS. Currently, no pharmacological treatment for FS is consistently successful. According to recent guidelines, the optimal treatment of FS requires a multidisciplinary approach with a combination of non-pharmacological and pharmacological treatment modalities. Spa therapy is a popular treatment for FS in many European countries, as well as in Japan and Israel. However, despite their long history and popularity spa treatments are still the subject of debate and their role in modern medicine is still not clear. The objective of this review is to summarize the currently available information on clinical effects and mechanism of action of spa therapy in FS. We also provide some suggestions for further development in this area.

  11. Romanian spa tourism: a communist paradigm in a post communist era

    OpenAIRE

    George Erdeli; Ana Irina Dincă; Aurel Gheorghilas; Camelia Surugiu

    2011-01-01

    Spa tourism is one of the oldest forms of tourism which continuously evolved in time as the leisure industry paradigm and the consumers’ behavior changed. Similar to other countries in Central and Eastern Europe, spa tourism is an old phenomenon in Romania which expanded to the dimensions of a well defined tourism industry during the mass tourism period which also corresponded to the communism epoch. Although severely affected by the major political and socio-economic changes which occurred a...

  12. Supersymmetry Parameter Analysis : SPA Convention and Project

    CERN Document Server

    Aguilar-Saavedra, J A; Allanach, Benjamin C; Arnowitt, R; Baer, H A; Bagger, J A; Balázs, C; Barger, V; Barnett, M; Bartl, Alfred; Battaglia, M; Bechtle, P; Belyaev, A; Berger, E L; Blair, G; Boos, E; Bélanger, G; Carena, M S; Choi, S Y; Deppisch, F; Desch, Klaus; Djouadi, A; Dutta, B; Dutta, S; Díaz, M A; Eberl, H; Ellis, Jonathan Richard; Erler, Jens; Fraas, H; Freitas, A; Fritzsche, T; Godbole, Rohini M; Gounaris, George J; Guasch, J; Gunion, J F; Haba, N; Haber, Howard E; Hagiwara, K; Han, L; Han, T; He, H J; Heinemeyer, S; Hesselbach, S; Hidaka, K; Hinchliffe, Ian; Hirsch, M; Hohenwarter-Sodek, K; Hollik, W; Hou, W S; Hurth, Tobias; Jack, I; Jiang, Y; Jones, D R T; Kalinowski, Jan; Kamon, T; Kane, G; Kang, S K; Kernreiter, T; Kilian, W; Kim, C S; King, S F; Kittel, O; Klasen, M; Kneur, J L; Kovarik, K; Kraml, Sabine; Krämer, M; Lafaye, R; Langacker, P; Logan, H E; Ma, W G; Majerotto, Walter; Martyn, H U; Matchev, K; Miller, D J; Mondragon, M; Moortgat-Pick, G; Moretti, S; Mori, T; Moultaka, G; Muanza, S; Mukhopadhyaya, B; Mühlleitner, M M; Nauenberg, U; Nojiri, M M; Nomura, D; Nowak, H; Okada, N; Olive, Keith A; Oller, W; Peskin, M; Plehn, T; Polesello, G; Porod, Werner; Quevedo, Fernando; Rainwater, D L; Reuter, J; Richardson, P; Rolbiecki, K; de Roeck, A; Weber, Ch.

    2006-01-01

    High-precision analyses of supersymmetry parameters aim at reconstructing the fundamental supersymmetric theory and its breaking mechanism. A well defined theoretical framework is needed when higher-order corrections are included. We propose such a scheme, Supersymmetry Parameter Analysis SPA, based on a consistent set of conventions and input parameters. A repository for computer programs is provided which connect parameters in different schemes and relate the Lagrangian parameters to physical observables at LHC and high energy e+e- linear collider experiments, i.e., masses, mixings, decay widths and production cross sections for supersymmetric particles. In addition, programs for calculating high-precision low energy observables, the density of cold dark matter (CDM) in the universe as well as the cross sections for CDM search experiments are included. The SPA scheme still requires extended efforts on both the theoretical and experimental side before data can be evaluated in the future at the level of the d...

  13. Neuroendocrine-immune and metabolic accompaniments of cholecystokinetic effects of balneotherapy on SPA Truskavets’

    Directory of Open Access Journals (Sweden)

    O M Marfiyan

    2015-05-01

    4Faculty of Physical Education, Health and Tourism, Kazimierz Wielki University, Bydgoszcz, Poland w.zukow@ukw.edu.pl   SUMMARY   Objective. Ability balneofactors spa Truskavets’ (Ukraine, including bioactive water Naftussya, affect Gall-bladder motility has long been known. We set a goal to identify changes related neuroendocrine-immune complex and metabolism accompanying cholecystokinetic effect of balneotherapy on spa. Results. In observation of 22 men with chronic cholecystitis in combination with pyelonephritis, found that 10-12-day course of balneotherapy (drinking of bioactive water Naftussya, application of ozokerite, mineral baths reduces Gall-bladder volume fasting by 16% (p0,05, by increasing PSD HF greater extent than LF. The basal levels of plasma cortisol decreased by 20% (p0,2 and 8% (p<0,05 respectively. Regarding immunity parameters revealed significant increase in blood CD16+ lymphocytes only (+17%, p<0,01 in the absence of changes in levels of CD3+CD4+ and CD3+CD8+ T cells and CD19+ B lymphocytes. Do not change significantly either serum Igg G, M, A, or circulating immune complexes. Finally, stated a slight but significant increase electrokinetic index cell nuclei of buccal epithelium, indicating the "rejuvenation" of the body. Conclusion: balneotherapy on spa Truskavets’ be significantly cholecystokinetic effect, combined with the activation excretory and depurative kidney functions and neutrophil bactericidal function against a background of lower levels of neuroendocrine markers of stress. Keywords: Truskavets’, balneotherapy, cholekinetic, diuresis, neuroendocrine-immune complex.

  14. The SPA Tourism Perception in Romania

    Directory of Open Access Journals (Sweden)

    Ionica SOARE

    2014-11-01

    Full Text Available Tourism or geriatric-medical and wellness tourism are market segments that lately have registered significant increases. The need to define, organize, and promote these sectors. This item is intended to synthesize developments and challenges market growth wellness and medical tourism. For the industry spa these developments may represent an opportunity to take full advantage of wellness and medical tourism.

  15. Romanian spa tourism: a communist paradigm in a post communist era

    Directory of Open Access Journals (Sweden)

    George Erdeli

    2011-11-01

    Full Text Available Spa tourism is one of the oldest forms of tourism which continuously evolved in time as the leisure industry paradigm and the consumers’ behavior changed. Similar to other countries in Central and Eastern Europe, spa tourism is an old phenomenon in Romania which expanded to the dimensions of a well defined tourism industry during the mass tourism period which also corresponded to the communism epoch. Although severely affected by the major political and socio-economic changes which occurred after the Revolution in 1989, this industry coexists with new emergent forms of tourism orienting, itself towards new dimensions embraced by the contemporary leisure consumerism (e.g. medical tourism, cosmetic treatments. Lying on considerable balneal and climate resources and displaying an important communist heritage both in physical terms (large and massive tourism structures and in virtual and psychological terms (social supportive ticket granting system, Romanian spa tourism faces various challenges in the attempt to adapt in a new tourism era.

  16. Waste heat utilization in the thermal spa of Lavey-les-Bains

    International Nuclear Information System (INIS)

    2004-01-01

    This final report for the Swiss Federal Office of Energy looks at the possibilities for improved waste water utilization in the Lavey-les-Bains thermal spa, Switzerland. According to the regulations in force, the temperature of the waste water rejected into the Rhone river shall not exceed 30 o C, what is currently not the case. Also the operational cost shall be reduced and the waste water quality improved. The installations are presented. From the two geothermal wells, mineral water comes out at an average flow rate of 940 l/min and a temperature of 63 o C. Actual waste water data are reported. The measured thermal water consumption data, including seasonal variations, are analysed by computerized simulation and measures to reduce the consumed volume by the optimization of internal procedures are evaluated. Measures to reduce the quantity of the rejected free chlorine are discussed. Several possible adaptations of the existing space heating, domestic water heating and pools' heating are evaluated, including cost. In addition, extensions of the thermal spa center to recreational activities are discussed, as the construction of a tropical greenhouse is

  17. Modified Decoding Algorithm of LLR-SPA

    Directory of Open Access Journals (Sweden)

    Zhongxun Wang

    2014-09-01

    Full Text Available In wireless sensor networks, the energy consumption is mainly occurred in the stage of information transmission. The Low Density Parity Check code can make full use of the channel information to save energy. Because of the widely used decoding algorithm of the Low Density Parity Check code, this paper proposes a new decoding algorithm which is based on the LLR-SPA (Sum-Product Algorithm in Log-Likelihood-domain to improve the accuracy of the decoding algorithm. In the modified algorithm, a piecewise linear function is used to approximate the complicated Jacobi correction term in LLR-SPA decoding algorithm. Construct the tangent by the tangency point to the function of Jacobi correction term, which is based on the first order Taylor Series. In this way, the proposed piecewise linear approximation offers almost a perfect match to the function of Jacobi correction term. Meanwhile, the proposed piecewise linear approximation could avoid the operation of logarithmic which is more suitable for practical application. The simulation results show that the proposed algorithm could improve the decoding accuracy greatly without noticeable variation of the computational complexity.

  18. 75 FR 76038 - Zach System Corporation a Subdivision of Zambon Company, SPA Including On-Site Leased Workers of...

    Science.gov (United States)

    2010-12-07

    ... Subdivision of Zambon Company, SPA Including On-Site Leased Workers of Turner Industries and Go Johnson, La..., including on-site leased workers from Turner Industries and Go Johnson, La Porte, Texas. The Department's... investigation revealed that Zach System Corporation is a subdivision of Zambon Company, SPA, not Zach System SPA...

  19. Molecular analysis of virulent genes (coa and spa) of staphylococcus aureus involved in natural cases of bovine mastitis

    International Nuclear Information System (INIS)

    Khan, A.; Javed, M.T.; Mahmood, F.; Hussain, R.

    2013-01-01

    The present study was undertaken to determine the distribution and genotypic characteristics of Staphylococcus aureus isolates recovered from naturally occurring mastitis in cattle and buffaloes. For this purpose a total of 1445 lactating cattle (653) and buffaloes (792) present at two experimental livestock farms Okara (Bahadarnagar) and Sahiwal (Qadiarabad), in and around district Faisalabad and slaughtered at an abattoir due to low milk yield and were screened for mastitis. California Mastitis Test (CMT) was used to detect sub clinical mastitis. The positive quarter milk samples were collected for culturing of S. aureus isolates. taphylococcus aureus isolates were identified on the basis of growth features, biochemical characteristics, coagulase test and as well as amplification of coagulase (coa) and spa (spa-X) genes specific to its virulence. S. aureus isolates (n=265) were characterized by Polymerase chain reaction to determine the frequency of coagulase (coa) and spa (spa-X) genes. From these isolates the amplification of the coagulase (coa) gene yielded three different PCR products approximately 204bp to 490bp while spa (spa-X) gene produced five different products ranging in size from 190bp to 320bp. PCR revealed that from all the coagulase positive S. aureus isolates 261(98.5%) had spa (spa-X) gene. The results of the present study indicated that S. aureus isolates recovered from bovine mastitis were genetically different within and among the various herds which may provide essential and valuable strategies to control staphylococcal infections in future. (author)

  20. Molecular analysis of virulent genes (coa and spa) of staphylococcus aureus involved in natural cases of bovine mastitis

    Energy Technology Data Exchange (ETDEWEB)

    Khan, A.; Javed, M. T.; Mahmood, F. [University of Agriculture, Faisalabad (Pakistan). Dept. of Pathology; Hussain, R. [The Islamia Univ. of Bahawalpur, Pakistan (Pakistan). Dept. of Veterinary and Animal Sciences

    2013-12-15

    The present study was undertaken to determine the distribution and genotypic characteristics of Staphylococcus aureus isolates recovered from naturally occurring mastitis in cattle and buffaloes. For this purpose a total of 1445 lactating cattle (653) and buffaloes (792) present at two experimental livestock farms Okara (Bahadarnagar) and Sahiwal (Qadiarabad), in and around district Faisalabad and slaughtered at an abattoir due to low milk yield and were screened for mastitis. California Mastitis Test (CMT) was used to detect sub clinical mastitis. The positive quarter milk samples were collected for culturing of S. aureus isolates. taphylococcus aureus isolates were identified on the basis of growth features, biochemical characteristics, coagulase test and as well as amplification of coagulase (coa) and spa (spa-X) genes specific to its virulence. S. aureus isolates (n=265) were characterized by Polymerase chain reaction to determine the frequency of coagulase (coa) and spa (spa-X) genes. From these isolates the amplification of the coagulase (coa) gene yielded three different PCR products approximately 204bp to 490bp while spa (spa-X) gene produced five different products ranging in size from 190bp to 320bp. PCR revealed that from all the coagulase positive S. aureus isolates 261(98.5%) had spa (spa-X) gene. The results of the present study indicated that S. aureus isolates recovered from bovine mastitis were genetically different within and among the various herds which may provide essential and valuable strategies to control staphylococcal infections in future. (author)

  1. [Measurement of soil organic matter and available K based on SPA-LS-SVM].

    Science.gov (United States)

    Zhang, Hai-Liang; Liu, Xue-Mei; He, Yong

    2014-05-01

    Visible and short wave infrared spectroscopy (Vis/SW-NIRS) was investigated in the present study for measurement of soil organic matter (OM) and available potassium (K). Four types of pretreatments including smoothing, SNV, MSC and SG smoothing+first derivative were adopted to eliminate the system noises and external disturbances. Then partial least squares regression (PLSR) and least squares-support vector machine (LS-SVM) models were implemented for calibration models. The LS-SVM model was built by using characteristic wavelength based on successive projections algorithm (SPA). Simultaneously, the performance of LSSVM models was compared with PLSR models. The results indicated that LS-SVM models using characteristic wavelength as inputs based on SPA outperformed PLSR models. The optimal SPA-LS-SVM models were achieved, and the correlation coefficient (r), and RMSEP were 0. 860 2 and 2. 98 for OM and 0. 730 5 and 15. 78 for K, respectively. The results indicated that visible and short wave near infrared spectroscopy (Vis/SW-NIRS) (325 approximately 1 075 nm) combined with LS-SVM based on SPA could be utilized as a precision method for the determination of soil properties.

  2. Comparing Whole-Genome Sequencing with Sanger Sequencing for spa Typing of Methicillin-Resistant Staphylococcus aureus

    DEFF Research Database (Denmark)

    Bartels, Mette Damkjaer; Petersen, Andreas; Worning, Peder

    2014-01-01

    spa typing of methicillin-resistant Staphylococcus aureus (MRSA) has traditionally been done by PCR amplification and Sanger sequencing of the spa repeat region. At Hvidovre Hospital, Denmark, whole-genome sequencing (WGS) of all MRSA isolates has been performed routinely since January 2013, and ...

  3. Natural radioactivity in mineral and spa water: the current regulatory approach in Italy

    International Nuclear Information System (INIS)

    Nuccetelli, C.; Bochicchio, F.; Ruocco, G.

    2004-01-01

    Mineral and thermal waters can contain radioactivity of natural origin which, in some cases, can lead to radiation-protection problems for both workers and consumers. In Italy, as in many other countries, the consumption of bottled mineral water is rather high and the practice of spending short stays in spas is also popular. Consumer protection against natural radioactivity in mineral water is not regulated at all and exposure from thermal waters is not treated in detail, in either the European Union or Italy. For this reason, the Italian Ministry of Health - which has the duty to authorize spa activities and the sale of mineral water on the basis of water characteristics - asked the Istituto Superiore di Sanita (the Italian National Institute of Health) to provide ad-hoc reports containing both dosimetric calculations and analysis of the radiation-protection regulations to be applied in these situations. On the basis of these reports, the Ministry of Health decided, in two statements for spa and mineral waters respectively, to indicate upper levels for natural radioactivity content. Since 2002, spa water parameters have been in force for authorization of their use and sale, and are to be promulgated by specific and more comprehensive regulations. For mineral waters used for infant feeding and drinking, levels lower than those for general public uses have been proposed, in order to take into account the higher ingestion dose coefficients for infants. At the moment, mineral water levels are not enforced as law. This paper presents the dosimetric calculation results and the Ministry of Health statements. (Author) 17 refs

  4. Surfactant protein A (SP-A)-mediated clearance of Staphylococcus aureus involves binding of SP-A to the staphylococcal adhesin eap and the macrophage receptors SP-A receptor 210 and scavenger receptor class A.

    Science.gov (United States)

    Sever-Chroneos, Zvjezdana; Krupa, Agnieszka; Davis, Jeremy; Hasan, Misbah; Yang, Ching-Hui; Szeliga, Jacek; Herrmann, Mathias; Hussain, Muzafar; Geisbrecht, Brian V; Kobzik, Lester; Chroneos, Zissis C

    2011-02-11

    Staphylococcus aureus causes life-threatening pneumonia in hospitals and deadly superinfection during viral influenza. The current study investigated the role of surfactant protein A (SP-A) in opsonization and clearance of S. aureus. Previous studies showed that SP-A mediates phagocytosis via the SP-A receptor 210 (SP-R210). Here, we show that SP-R210 mediates binding and control of SP-A-opsonized S. aureus by macrophages. We determined that SP-A binds S. aureus through the extracellular adhesin Eap. Consequently, SP-A enhanced macrophage uptake of Eap-expressing (Eap(+)) but not Eap-deficient (Eap(-)) S. aureus. In a reciprocal fashion, SP-A failed to enhance uptake of Eap(+) S. aureus in peritoneal Raw264.7 macrophages with a dominant negative mutation (SP-R210(DN)) blocking surface expression of SP-R210. Accordingly, WT mice cleared infection with Eap(+) but succumbed to sublethal infection with Eap- S. aureus. However, SP-R210(DN) cells compensated by increasing non-opsonic phagocytosis of Eap(+) S. aureus via the scavenger receptor scavenger receptor class A (SR-A), while non-opsonic uptake of Eap(-) S. aureus was impaired. Macrophages express two isoforms: SP-R210(L) and SP-R210(S). The results show that WT alveolar macrophages are distinguished by expression of SP-R210(L), whereas SR-A(-/-) alveolar macrophages are deficient in SP-R210(L) expressing only SP-R210(S). Accordingly, SR-A(-/-) mice were highly susceptible to both Eap(+) and Eap(-) S. aureus. The lungs of susceptible mice generated abnormal inflammatory responses that were associated with impaired killing and persistence of S. aureus infection in the lung. In conclusion, alveolar macrophage SP-R210(L) mediates recognition and killing of SP-A-opsonized S. aureus in vivo, coordinating inflammatory responses and resolution of S. aureus pneumonia through interaction with SR-A.

  5. Willingness of patients with ankylosing spondylitis to pay for inpatient treatment is influenced by the treatment environment and expectations of improvement.

    Science.gov (United States)

    Boonen, A; Severens, J L; van Tubergen, A; Landewé, R; Bonsel, G; van der Heijde, D; van der Linden, Sj

    2005-11-01

    To assess the willingness to pay (WTP) for treatment in a spa resort of patients with ankylosing spondylitis (AS) and to assess if the experience of a spa influences the WTP. 120 patients participating in a randomised trial comparing 3 weeks' treatment in a spa resort in Austria or in the Netherlands with a control group completed a WTP questionnaire before and after spa treatment. Patients indicated on a payment card the maximal co-payment they wanted to contribute for three scenarios that included (a) two levels of improvement in pain and stiffness and (b) two treatment environments: a rehabilitation hospital and a spa resort. At baseline, patients wanted to contribute more for the same improvement after treatment in a spa resort compared with a rehabilitation hospital (ppay more when expected effects were higher (pexpected improvement. Experiencing treatment in a spa resort does not influence the co-payment.

  6. Hydrogeothermal characteristics of groundwater from Ribarska Banja spa, central Serbia

    Directory of Open Access Journals (Sweden)

    Dragišić Veselin S.

    2015-01-01

    Full Text Available Ribarska Banja spa is one of the most popular balneotherapy and recreation centers in Serbia. It features several thermal groundwater sources whose temperatures range from 26 to 54°C. The mineral content of these waters is low and their composition is of the SO4-Na or HCO3-Na type. Thermal water exploration has been conducted in the general area for many years, to assess the hydrogeothermal potential in order to extract larger amounts of thermal water for multiple uses. The hydrogeothermal system of Ribarska Banja spa was defined based on a synthesis of the results of comprehensive structural geology, geophysical, hydrogeological, hydrochemical and geothermal research. The primary groundwater reservoir of the hydrogeothermal system is comprised of tectonic zones (systems of faults and fractures within Cretaceous-Paleogene metamorphosed and non-metamorphosed rocks. The overlying hydrogeological and temperature barrier is made up of a series of low metamorphosed rocks (chlorite, chlorite-sericite schists, gabbros, etc., highly metamorphosed rocks (gneisses and Neogene clay and sand sediments. The system is recharged by infiltration of atmospheric precipitation and surface water at the highest elevations of Mt. Jastrebac. Investigations have also shown that the system’s heat source is younger granitoide intrusion spreading northwest of Ribarska Banja spa. Based on the quartz geothermometers, expected reservoir temperatures are in the range of 85-97°C that can be expected at a depth of 1.87 km. Total energy usage at Ribarska Banja spa is 31 TJ/y with thermal capacity of 1.65 MWt and utilization factor of 0.58. Geothermal gradient is 0,051°C/m, while heat flow density is 163.5 mW/m2. [Projekat Ministarstva nauke Republike Srbije, br. 43004

  7. [The spa-health resort and touristic-recreational facilities of the region: the methodological aspects of their development].

    Science.gov (United States)

    Kirilina, V M; Kolesnikova, N V; Kolesnikov, N G

    2016-01-01

    The correction and optimization of the motor activity of the patients are currently the main priorities of all rehabilitative and recreational activities based at the spa and health resort facilities. The forms of such activities include walking tours and excursion trips. In other words, the excursion potential is one of the very important attributes of the recreational recourses. Under the current conditions characterized by the rapid socio-economic changes, the studies concerning the structural and functional transformation of spa and health resorts, recreational and tourist facilities acquire special importance, both from the humanitarian and economic points of view. The results of these studies may greatly contribute to the organization and the further development of rehabilitative and recreational activities based at the spa and health resort facilities, recreational and tourist centers taking into consideration their evolution. The objective of the present article is to analyze the structure and functions of the recreation and tourist centres as well as the modes of their cooperation with the spa and health resort facilities. In other words, these structures and their functions are both the object and the subject of the present study. The methodology of the study is based on the logical analysis of the development of the recreational and tourist systems in the framework of the evolutionary approach. (1) the notions of «tourist destination» and «recreation» have been substantiated; (2) the results of the studies carried out at the Institute of Physical Culture, Sports and Tourism and the Petrozavodsk State University have been used to elaborate the affiliate international Master Degree program «Project management in the tourism industry». The main emphasis in this program is placed on the necessity and methods of the improvement of recreational activities and more efficacious utilization of the climatic factors and the health resort infrastructure as

  8. A checklist to assess the quality of reports on spa therapy and balneotherapy trials was developed using the Delphi consensus method: the SPAC checklist.

    Science.gov (United States)

    Kamioka, Hiroharu; Kawamura, Yoichi; Tsutani, Kiichiro; Maeda, Masaharu; Hayasaka, Shinya; Okuizum, Hiroyasu; Okada, Shinpei; Honda, Takuya; Iijima, Yuichi

    2013-08-01

    The purpose of this study was to develop a checklist of items that describes and measures the quality of reports of interventional trials assessing spa therapy. The Delphi consensus method was used to select the number of items in the checklist. A total of eight individuals participated, including an epidemiologist, a clinical research methodologist, clinical researchers, a medical journalist, and a health fitness programmer. Participants ranked on a 9-point Likert scale whether an item should be included in the checklist. Three rounds of the Delphi method were conducted to achieve consensus. The final checklist contained 19 items, with items related to title, place of implementation (specificity of spa), care provider influence, and additional measures to minimize the potential bias from withdrawals, loss to follow-up, and low treatment adherence. This checklist is simple and quick to complete, and should help clinicians and researchers critically appraise the medical and healthcare literature, reviewers assess the quality of reports included in systematic reviews, and researchers plan interventional trials of spa therapy. Copyright © 2013 Elsevier Ltd. All rights reserved.

  9. The Role of Aspiration Level in Risky Choice: A Comparison of Cumulative Prospect Theory and SP/A Theory.

    Science.gov (United States)

    Lopes; Oden

    1999-06-01

    In recent years, descriptive models of risky choice have incorporated features that reflect the importance of particular outcome values in choice. Cumulative prospect theory (CPT) does this by inserting a reference point in the utility function. SP/A (security-potential/aspiration) theory uses aspiration level as a second criterion in the choice process. Experiment 1 compares the ability of the CPT and SP/A models to account for the same within-subjects data set and finds in favor of SP/A. Experiment 2 replicates the main finding of Experiment 1 in a between-subjects design. The final discussion brackets the SP/A result by showing the impact on fit of both decreasing and increasing the number of free parameters. We also suggest how the SP/A approach might be useful in modeling investment decision making in a descriptively more valid way and conclude with comments on the relation between descriptive and normative theories of risky choice. Copyright 1999 Academic Press.

  10. spa typing and antimicrobial resistance of Staphylococcus aureus from healthy humans, pigs and dogs in Tanzania.

    Science.gov (United States)

    Katakweba, Abdul Sekemani; Muhairwa, Amandus Pachificus; Espinosa-Gongora, Carmen; Guardabassi, Luca; Mtambo, Madundo M A; Olsen, John Elmerdahl

    2016-02-28

    Staphylococcus aureus is an opportunistic pathogen causing infections in humans and animals. Here we report for the first time the prevalence of nasal carriage, spa typing and antimicrobial resistance of S. aureus in a Tanzanian livestock community. Nasal swabs were taken from 100 humans, 100 pigs and 100 dogs in Morogoro Municipal. Each swab was enriched in Mueller Hinton broth with 6.5% NaCl and subcultured on chromogenic agar for S. aureus detection. Presumptive S. aureus colonies were confirmed to the species level by nuc PCR and analysed by spa typing. Antimicrobial susceptibility patterns were determined by disc diffusion method. S. aureus was isolated from 22% of humans, 4% of pigs and 11% of dogs. A total of 21 spa types were identified: 13, 7 and 1 in human, dogs, and pigs, respectively. Three spa types (t314, t223 and t084) were shared between humans and dogs. A novel spa type (t10779) was identified in an isolate recovered from a colonized human. Antimicrobials tested revealed resistance to ampicillin in all isolates, moderate resistances to other antimicrobials with tetracycline resistance being the most frequent. S. aureus carrier frequencies in dogs and humans were within the expected range and low in pigs. The S. aureus spa types circulating in the community were generally not shared by different hosts and majority of types belonged to known clones. Besides ampicillin resistance, moderate levels of antimicrobial resistance were observed irrespective of the host species from which the strains were isolated.

  11. Pulling Marbles from a Bag: Deducing the Regional Impact History of the SPA Basin from Impact Melt Rocks

    Science.gov (United States)

    Cohen, Barbara A.; Coker, R. F.

    2009-01-01

    The South Pole-Aitken (SPA) basin is an important target for absolute age-dating. Vertical and lateral impact mixing ensures that regolith within SPA will contain rock fragments from SPA itself, local impact craters, and faraway giant basins. About 20% of the regolith at any given site is foreign [1, 2], but much of this material will be cold ejecta, not impact melt. We calculated the fraction of contributed impact melt using scaling laws to estimate the amount and provenance of impact melt, demonstrating that SPA melt is the dominant impact melt rock (>70%) likely to be present. We also constructed a statistical model to illustrate how many randomly-selected impact-melt fragments would need to be dated, and with what accuracy, to confidently reproduce the impact history of a site. A detailed impact history becomes recognizable after a few hundred to a thousand randomly-selected marbles, however, it will be useful to have more information (e.g. compositional, mineralogical, remote sensing) to group fragments. These exercises show that SPA melt has a high probability of being present in a scoop sample and that dating of a few hundred to a thousand impact-melt fragments will yield the impact history of the SPA basin.

  12. Potentials for development of spa tourism in region of Cer Mountain: Western Serbia

    Directory of Open Access Journals (Sweden)

    Grčić Mirko

    2006-01-01

    Full Text Available Because of their particularities, thermal and mineral springs at the foothill of Cer Mountain deserve special analysis. This is the reason we wrote this article, aiming to take reader's attention to the touristic potentials of the spa zone of Cer Mountain and possibilities for its perspective development. From the medical and excursion-recreational tourism point of view, there is a possibility for combining the spa tourism with the complementary values of Cer Mountain.

  13. Disinfection of herbal spa pool using combined chlorine dioxide and sodium hypochlorite treatment.

    Science.gov (United States)

    Hsu, Ching-Shan; Huang, Da-Ji

    2015-02-01

    The presence of pathogenic microorganisms in public spa pools poses a serious threat to human health. The problem is particularly acute in herbal spas, in which the herbs and microorganisms may interact and produce undesirable consequences. Accordingly, the present study investigated the effectiveness of a combined disinfectant containing chlorine dioxide and sodium hypochlorite in improving the water quality of a public herbal spa in Taiwan. Water samples were collected from the spa pool and laboratory tests were then performed to measure the variation over time of the microorganism content (total CFU and total coliforms) and residual disinfectant content given a single disinfection mode (SDM) with disinfectant concentrations of 5.2 × 10, 6.29 × 10, 7.4 × 10, and 11.4 × 10(-5) N, respectively. Utilizing the experience gained from the laboratory tests, a further series of on-site investigations was performed using three different disinfection modes, namely SDM, 3DM (once every 3 h disinfection mode), and 2DM (once every 2 h disinfection mode). The laboratory results showed that for all four disinfectant concentrations, the CFU concentration reduced for the first 6 h following SDM treatment, but then increased. Moreover, the ANOVA results showed that the sample treated with the highest disinfectant concentration (11.4 × 10(-5) N) exhibited the lowest rate of increase in the CFU concentration. In addition, the on-site test results showed that 3DM and 2DM treatments with disinfectant concentrations in excess of 9.3 × 10 and 5.5 × 10(-5) N, respectively, provided an effective reduction in the total CFU concentration. In conclusion, the experimental results presented in this study provide a useful source of reference for spa businesses seeking to improve the water quality of their spa pools.

  14. IMPLEMENTATION OF EU DIRECTIVES FOR CERTIFICATION OF THE STAFF IN THE SPA BUSINESS IN BULGARIA

    Directory of Open Access Journals (Sweden)

    Petya Kutincheva

    2013-07-01

    Full Text Available Implemented was a psychometric experiment for survey the opinion of the leading experts from the 4 and 5 stars hotels and the first SPA certified MSc - SPA managers. The summarized results from the study highlight that the priorities are related to improve the quality of the services in the SPA business. We establish the acute need for increasing professional qualification of the personnel and harmonize the Bulgarian legislation with the EU directives. In this regard it is important to implement the national classificatory with new professions and unified for this purpose the theoretical categories: “Results of advanced training", "knowledge", "practical skills" and "competencies" in educational and qualification degree: “Bachelor", "MasterSc" and "PhD ".

  15. Patient education and rehabilitation after hip arthroplasty in an Italian spa center: a pilot study on its feasibility

    Science.gov (United States)

    Musumeci, Alfredo; Pranovi, Giulia; Masiero, Stefano

    2018-05-01

    Nowadays, some spa centers are suitable for providing rehabilitative and preventive treatment in association with traditional spa therapy. This study aims to evaluate the feasibility and the effectiveness of an intensive rehabilitation program after hip arthroplasty in an Italian spa center. Early after total hip arthroplasty for severe osteoarthritis (≤ 10 days after the intervention), 12 consecutive patients (5 males and 7 females) aged between 50 and 85 years were enrolled for this study. All the patients performed a 2-week thermal multimodal rehabilitation program, which consisted of education and physical rehabilitative measures. Patients had 2-h and half/day session of land-based and hydrokinesitherapy (aquatic therapy) consisted in active and passive joint mobilization, respiratory and functional re-education exercises, gait and balance training, resistance exercise, and power training mainly for the upper limb associated to physical therapy modalities (electrotherapy and low-level laser therapy). An educational program was performed to both patients and families. Both before and after the rehabilitation treatment, patients underwent clinical evaluation, hip flexion/abduction range of motion, and Numeric Pain Rating Scale. Harris Hip Score (HHS) and SF-12 questionnaires (physical—PCS-12—and mental health component—MCS-12) were also administered. After the 2-week thermal spa treatment, hip flexion/abduction improved significantly (p < 0.05), but there was no statistically significant reduction in pain (p = 0.350). The HHS score improved significantly from 62.6 ± 12.8 to 82.15 ± 12.7 (p < 0.05), and the PCS-12 score from 36.37 ± 8.4 to 43.61 ± 8.95 (p < 0.05). There was no adverse event during spa treatment. After total hip arthroplasty, patients who underwent an intensive post-acute multimodal rehabilitation program showed an improvement in motor and functional recovery and a positive impact on quality of life. Therefore, we believe that the

  16. 76 FR 54403 - Airworthiness Directives; PIAGGIO AERO INDUSTRIES S.p.A Model PIAGGIO P-180 Airplanes

    Science.gov (United States)

    2011-09-01

    ... Federal holidays. For service information identified in this proposed AD, contact Piaggio Aero Industries... Service Information Piaggio Aero Industries S.p.A. has issued Mandatory Service Bulletin No. 80-0304... Accomplishment Instructions of Piaggio Aero Industries S.p.A. Mandatory Service Bulletin No. 80-0304, dated July...

  17. AIR SEBAGAI ALAT PENGENDALI IKLIM MIKRO DALAM BANGUNAN Studi Kasus : Taman Sari Royal Heritage Spa, Hotel Sheraton Mustika Yogyakarta

    Directory of Open Access Journals (Sweden)

    Dyah Hendrawati

    2016-07-01

    Full Text Available Indonesia is a country with wet tropical climate has constraints in obtaining thermal comfort because of the high air temperature, high air humidity and lower air speed. Modification of the microclimate might be conducted by increasing the cooling effect in a passive manner. Water can be used as one of control strategy thermal to build the microclimate or to site. Water also played an important role in lowering temperature and raise humidity in a room in building.Taman Sari Royal Heritage Spa, which is located in Yogyakarta,is one of building that implementing water as thermal control by making pool in door. This research aims to understand the influence of water in controlling the micro climate and the anything influence it .This research uses the quantitative methods by conducting observation and measuring temperature and humidity directly to the research objects. Secondary data is needed in this research. There was also literature review on the stuff that supports research, and a literature study was also conducted. The research and analysis on the results shows that 1 .The room in Tamansari royal heritage spa still in comfort zone in thermal .2 .The volume of water affects temperatures and humidity room 3 .Distance is a significant factor.

  18. Spa Garden in Daruvar – Methods of Renewal and Reconstruction

    Directory of Open Access Journals (Sweden)

    Šćitaroci Mladen Obad

    2014-12-01

    Full Text Available Spa garden in Daruvar ‘Julius’s Park’ is the oldest spa garden in continental Croatia. The counts Jankovich and their successors created the garden during the 18th and 20th century. The garden resumed its nowadays form and surface in the time of count Julius Jankovich in the mid-19th century and it was named after him. The garden is protected as a cultural heritage. The garden’s renovation is seen as an urban, architectural and landscape unity and it attempts to affirm the missing and neglected parts of the garden, to provide technological and municipal space modernization and to make a pleasant urban garden ambiance with new facilities and high space arrangement qualities, contributing to the economic development of the local community.

  19. Comparison of the DiversiLab Repetitive Element PCR System with spa Typing and Pulsed-Field Gel Electrophoresis for Clonal Characterization of Methicillin-Resistant Staphylococcus aureus▿

    Science.gov (United States)

    Babouee, B.; Frei, R.; Schultheiss, E.; Widmer, A. F.; Goldenberger, D.

    2011-01-01

    The emergence of methicillin-resistant Staphylococcus aureus (MRSA) has become an increasing problem worldwide in recent decades. Molecular typing methods have been developed to identify clonality of strains and monitor spread of MRSA. We compared a new commercially available DiversiLab (DL) repetitive element PCR system with spa typing, spa clonal cluster analysis, and pulsed-field gel electrophoresis (PFGE) in terms of discriminatory power and concordance. A collection of 106 well-defined MRSA strains from our hospital was analyzed, isolated between 1994 and 2006. In addition, we analyzed 6 USA300 strains collected in our institution. DL typing separated the 106 MRSA isolates in 10 distinct clusters and 8 singleton patterns. Clustering analysis into spa clonal complexes resulted in 3 clusters: spa-CC 067/548, spa-CC 008, and spa-CC 012. The discriminatory powers (Simpson's index of diversity) were 0.982, 0.950, 0.846, and 0.757 for PFGE, spa typing, DL typing, and spa clonal clustering, respectively. DL typing and spa clonal clustering showed the highest concordance, calculated by adjusted Rand's coefficients. The 6 USA300 isolates grouped homogeneously into distinct PFGE and DL clusters, and all belonged to spa type t008 and spa-CC 008. Among the three methods, DL proved to be rapid and easy to perform. DL typing qualifies for initial screening during outbreak investigation. However, compared to PFGE and spa typing, DL typing has limited discriminatory power and therefore should be complemented by more discriminative methods in isolates that share identical DL patterns. PMID:21307215

  20. Allegheny County Public Swimming Pool, Hot Tub, and Spa Inspections

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Public swimming pool, hot tub, and spa facilities are licensed and inspected once each year to assure proper water quality, sanitation, lifeguard coverage and...

  1. Crystallization and X-ray diffraction analysis of SpaE, a basal pilus protein from the gut-adapted Lactobacillus rhamnosus GG.

    Science.gov (United States)

    Mishra, Arjun K; Megta, Abhin Kumar; Palva, Airi; von Ossowski, Ingemar; Krishnan, Vengadesan

    2017-06-01

    SpaE is the predicted basal pilin subunit in the sortase-dependent SpaFED pilus from the gut-adapted and commensal Lactobacillus rhamnosus GG. Thus far, structural characterization of the cell-wall-anchoring basal pilins has remained difficult and has been limited to only a few examples from pathogenic genera and species. To gain a further structural understanding of the molecular mechanisms that are involved in the anchoring and assembly of sortase-dependent pili in less harmful bacteria, L. rhamnosus GG SpaE for crystallization was produced by recombinant expression in Escherichia coli. Although several attempts to crystallize the SpaE protein were unsuccessful, trigonal crystals that diffracted to a resolution of 3.1 Å were eventually produced using PEG 3350 as a precipitant and high protein concentrations. Further optimization with a combination of additives led to the generation of SpaE crystals in an orthorhombic form that diffracted to a higher resolution of 1.5 Å. To expedite structure determination by SAD phasing, selenium-substituted (orthorhombic) SpaE crystals were grown and X-ray diffraction data were collected to 1.8 Å resolution.

  2. Solec Spa – worldwide unique properties of Polish health resort in the service of rural medicine

    Directory of Open Access Journals (Sweden)

    Marek L Grabowski

    2018-03-01

    Full Text Available Solec Spa is health resort in south-eastern Poland. Its unique balneorehabilitation significance worldwide is determined by chloride-iodine-sodium water with a high content of hydrogen sulphide. This water, classified as highly mineralized sodium-chloride (seltzer sulphide, bromide, iodide, boron water, contains naturally approximately 0.9 g/l divalent sulphur compounds, which is the highest concentration noted among the mineral waters of the world. The effectiveness of the Solec waters is proven in: inflammatory and autoimmunological locomotor system diseases, degenerative joint disorders (osteoarthritis, post-traumatic and post-operative orthopedic diseases, skin diseases and allergic disorders. One of the main indications for balneotherapy in Solec Spa and Busko Spa is chronic brucellosis.

  3. Plan de negocios: Samay Spa Mujer

    OpenAIRE

    Espol; García Viteri, Maria Del Carmen; Valle SÁnchez, Francisco; Pauta, MarÍa Alexandra

    2015-01-01

    Samay spa mujer, diseñado como centro de bienestar, belleza y salud de la mujer guayaquileña ejecutiva, pone a su disposición un ambiente armonioso con soluciones para mantener y mejorar su imagen personal y eliminar el estrés. lograremos que la mujer sienta bienestar, descanso, cuidado de su cuerpo, disfrute de preciosos momentos, a través d eun variado paquete de servicios con el respaldo de equipos modernos de alta tecnología de la conocida maraca española sorisa y productos esteé lauder, ...

  4. Effect of a steam foot spa on geriatric inpatients with cognitive impairment: a pilot study

    OpenAIRE

    Koike Y; Kondo H; Kondo S; Takagi M; Kano Y

    2013-01-01

    Yoshihisa Koike,1 Hideki Kondo,2 Satoshi Kondo,1 Masayuki Takagi,1 Yoshio Kano31Department of Occupational Therapy, Prefectural University of Hiroshima, Mihara, Japan; 2Yoshiigawa Hospital, Okayama, Japan; 3Department of Occupational Therapy, Kibi International University, Takahashi, JapanPurpose: To investigate whether a steam foot spa improves cognitive impairment in geriatric inpatients.Methods: Geriatric inpatients with cognitive impairment were given a steam foot spa treatment at 42&...

  5. Willingness of patients with ankylosing spondylitis to pay for inpatient treatment is influenced by the treatment environment and expectations of improvement

    NARCIS (Netherlands)

    Boonen, A.; Severens, J. L.; van Tubergen, A.; Landewé, R.; Bonsel, G.; van der Heijde, D.; van der Linden, Sj

    2005-01-01

    Objective: To assess the willingness to pay (WTP) for treatment in a spa resort of patients with ankylosing spondylitis ( AS) and to assess if the experience of a spa influences the WTP. Methods: 120 patients participating in a randomised trial comparing 3 weeks' treatment in a spa resort in Austria

  6. Market segment of families with children: a new stimulus for modern Czech spa industry?

    Directory of Open Access Journals (Sweden)

    Darina Jelínková

    2017-06-01

    Full Text Available The paper deals with a comprehensive range of hotel services for families with children at spa facilities of the Czech Republic, in line with current trends and requirements of this market segment. The main goal of this paper is to determine the preferences, needs and requirements of families with children in terms of amenities and services offer at spa hotels designated specifically for this target group. The secondary goal is to determine the current state of hotel services and facilities of Czech First Class hotels, which are the holders of the Baby Friendly Certificate. Subsequently, service offerings of these spa hotels are compared with the existing range of services for families with children in the selected Czech spas. In conclusion, based on the information obtained from the analyses and marketing research, a solution of the services portfolio intended for the market segment of families with children is recommended here using marketing mix as applied to tourism.

  7. Effects of Rusanda Spa balneotherapy combined with calcipotriol on plaque psoriasis

    Directory of Open Access Journals (Sweden)

    Golušin Zoran

    2015-01-01

    Full Text Available Background/Aim. Treatment of psoriasis is very complex and there are no still universal, nor unique treatment modalities. Apart from conventional treatment, which includes topical calcipotriol (vitamin D3 analogue, balneotherapy is drawing increased attention worldwide. Being part of climatotherapy, balneotherapy is defined as the use of natural environmental factors in the treatment of health conditions, whereas in the treatment of psoriasis it means the use of mineral baths and peloids. The aim of this study was to examine the therapeutic efficacy of mineral waters and peloids of the Rusanda Spa on plaque psoriasis in patients also treated with calcipotriol. Methods. The study included 60 patients divided into two groups. The first group included patients treated with mineral waters, peloids and calcipotriol in the Rusanda Spa, while the second one included those treated only with calcipotriol. The study took 21 days, and each patient was followed up for at least one month after ending the treatment. The treatment efficacy was measured by psoriasis area severity index (PASI scores on the days 0, 7, 14 and 21 during the treatment and 30 after the end of the therapy. Results. After a 3-week treatment in the Rusanda Spa, the first group showed a decrease in PASI score by 59.45%, whereas in the group of outpatients treated by calcipotriol it was 39.34%. On the day 30 following the treatment, the first group presented with the PASI score reduction of 58.44%, and the second group of 34.78%. The therapeutic efficacy of mineral waters and peloids combined with calcipotriol showed to be significantly higher in regard to monotherapy with calcipotriol (p < 0.05. In regard to clinical symptoms, the best results were obtained in the reduction of desquamation (p < 0.001. Conclusion. The results of our study show that in the treatment of plaque-type psoriasis, topical calcipotriol combined with Spa Rusanda balneotherapy is more effective than topical

  8. DNAGear- a free software for spa type identification in Staphylococcus aureus

    Science.gov (United States)

    2012-01-01

    Background Staphylococcus aureus is both human commensal and an important human pathogen, responsible for community-acquired and nosocomial infections ranging from superficial wound infections to invasive infections, such as osteomyelitis, bacteremia and endocarditis, pneumonia or toxin shock syndrome with a mortality rate up to 40%. S. aureus reveals a high genetic polymorphism and detecting the genotypes is extremely useful to manage and prevent possible outbreaks and to understand the route of infection. One of current and expanded typing method is based on the X region of the spa gene composed of a succession of repeats of 21 to 27 bp. More than 10000 types are known. Extracting the repeats is impossible by hand and needs a dedicated software. Unfortunately the only software on the market is a commercial program from Ridom. Findings This article presents DNAGear, a free and open source software with a user friendly interface written all in Java on top of NetBeans Platform to perform spa typing, detecting new repeats and new spa types and synchronizing automatically the files with the open access database. The installation is easy and the application is platform independent. In fact, the SPA identification is a formal regular expression matching problem and the results are 100% exact. As the program is using Java embedded modules written over string manipulation of well established algorithms, the exactitude of the solution is perfectly established. Conclusions DNAGear is able to identify the types of the S. aureus sequences and detect both new types and repeats. Comparing to manual processing, which is time consuming and error prone, this application saves a lot of time and effort and gives very reliable results. Additionally, the users do not need to prepare the forward-reverse sequences manually, or even by using additional tools. They can simply create them in DNAGear and perform the typing task. In short, researchers who do not have commercial software will

  9. DNAGear--a free software for spa type identification in Staphylococcus aureus.

    Science.gov (United States)

    AL-Tam, Faroq; Brunel, Anne-Sophie; Bouzinbi, Nicolas; Corne, Philippe; Bañuls, Anne-Laure; Shahbazkia, Hamid Reza

    2012-11-19

    Staphylococcus aureus is both human commensal and an important human pathogen, responsible for community-acquired and nosocomial infections ranging from superficial wound infections to invasive infections, such as osteomyelitis, bacteremia and endocarditis, pneumonia or toxin shock syndrome with a mortality rate up to 40%. S. aureus reveals a high genetic polymorphism and detecting the genotypes is extremely useful to manage and prevent possible outbreaks and to understand the route of infection. One of current and expanded typing method is based on the X region of the spa gene composed of a succession of repeats of 21 to 27 bp. More than 10000 types are known. Extracting the repeats is impossible by hand and needs a dedicated software. Unfortunately the only software on the market is a commercial program from Ridom. This article presents DNAGear, a free and open source software with a user friendly interface written all in Java on top of NetBeans Platform to perform spa typing, detecting new repeats and new spa types and synchronizing automatically the files with the open access database. The installation is easy and the application is platform independent. In fact, the SPA identification is a formal regular expression matching problem and the results are 100% exact. As the program is using Java embedded modules written over string manipulation of well established algorithms, the exactitude of the solution is perfectly established. DNAGear is able to identify the types of the S. aureus sequences and detect both new types and repeats. Comparing to manual processing, which is time consuming and error prone, this application saves a lot of time and effort and gives very reliable results. Additionally, the users do not need to prepare the forward-reverse sequences manually, or even by using additional tools. They can simply create them in DNAGear and perform the typing task. In short, researchers who do not have commercial software will benefit a lot from this

  10. [Impact of SPA therapy with sulphureous mineral water on quality of life and psychological distress in chronic plaque psoriasis].

    Science.gov (United States)

    Costantino, M; Filippelli, A

    2014-01-01

    The plaque psoriasis, one of the most common form of psoriasis, is a chronic inflammatory disease. This pathology can cause devastating effects on quality of life and social relations with significant physical and psychological distress. Currently among the therapeutic agents available for the treatment of psoriasis is including SPA therapy, whose mechanism of action is only partially known, as well as very few studies examined the impact of this therapy on the quality of life. On the basis of these considerations, the research analyzed the effectiveness of SPA bath therapy (BLT) and its impact on quality of life and psychological distress in patients suffering from chronic plaque psoriasis. The study was conducted on 35 patients with chronic plaque psoriasis: 23% male and 77% female; mean age:56 ± 19 years; age range:17-85 years. The subjects were treated, for 2 weeks, with sulphureous SPA bath therapy from Terme of Telese SpA (Benevento-Italy). At the beginning and at the end of the SPA treatment considered was evaluated: the itching symptom (using NRS scale); the PASI Index; the impact on quality of life (using SF-36 and DLQI questionnaires) and on psychological distress (using ZUNG -tests). At the end of the SPA treatment, the mean values ± SD, compared to baseline, have showed a significant (p 1.0 ± 1.0) and PASI score (4 ± 4-->1.7 ± 2) with an improvement in quality of life and psichological distress as demonstrated by SF-36, DLQI and ZUNG tests. The data of this research show that the sulphureous SPA bath therapy can be considered very useful in patients with mild-to-moderate psoriasis for the improving of the quality of life and social relationship.

  11. Distribution of the Most Prevalent Spa Types among Clinical Isolates of Methicillin-Resistant and -Susceptible Staphylococcus aureus around the World: A Review

    Directory of Open Access Journals (Sweden)

    Parisa Asadollahi

    2018-02-01

    Full Text Available Background:Staphylococcus aureus, a leading cause of community-acquired and nosocomial infections, remains a major health problem worldwide. Molecular typing methods, such as spa typing, are vital for the control and, when typing can be made more timely, prevention of S. aureus spread around healthcare settings. The current study aims to review the literature to report the most common clinical spa types around the world, which is important for epidemiological surveys and nosocomial infection control policies.Methods: A search via PubMed, Google Scholar, Web of Science, Embase, the Cochrane library, and Scopus was conducted for original articles reporting the most prevalent spa types among S. aureus isolates. The search terms were “Staphylococcus aureus, spa typing.”Results: The most prevalent spa types were t032, t008 and t002 in Europe; t037 and t002 in Asia; t008, t002, and t242 in America; t037, t084, and t064 in Africa; and t020 in Australia. In Europe, all the isolates related to spa type t032 were MRSA. In addition, spa type t037 in Africa and t037and t437 in Australia also consisted exclusively of MRSA isolates. Given the fact that more than 95% of the papers we studied originated in the past decade there was no option to study the dynamics of regional clone emergence.Conclusion: This review documents the presence of the most prevalent spa types in countries, continents and worldwide and shows big local differences in clonal distribution.

  12. Distribution of the Most Prevalent Spa Types among Clinical Isolates of Methicillin-Resistant and -Susceptible Staphylococcus aureus around the World: A Review.

    Science.gov (United States)

    Asadollahi, Parisa; Farahani, Narges Nodeh; Mirzaii, Mehdi; Khoramrooz, Seyed Sajjad; van Belkum, Alex; Asadollahi, Khairollah; Dadashi, Masoud; Darban-Sarokhalil, Davood

    2018-01-01

    Background: Staphylococcus aureus , a leading cause of community-acquired and nosocomial infections, remains a major health problem worldwide. Molecular typing methods, such as spa typing, are vital for the control and, when typing can be made more timely, prevention of S. aureus spread around healthcare settings. The current study aims to review the literature to report the most common clinical spa types around the world, which is important for epidemiological surveys and nosocomial infection control policies. Methods: A search via PubMed, Google Scholar, Web of Science, Embase, the Cochrane library, and Scopus was conducted for original articles reporting the most prevalent spa types among S. aureus isolates. The search terms were " Staphylococcus aureus, spa typing ." Results: The most prevalent spa types were t032, t008 and t002 in Europe; t037 and t002 in Asia; t008, t002, and t242 in America; t037, t084, and t064 in Africa; and t020 in Australia. In Europe, all the isolates related to spa type t032 were MRSA. In addition, spa type t037 in Africa and t037and t437 in Australia also consisted exclusively of MRSA isolates. Given the fact that more than 95% of the papers we studied originated in the past decade there was no option to study the dynamics of regional clone emergence. Conclusion: This review documents the presence of the most prevalent spa types in countries, continents and worldwide and shows big local differences in clonal distribution.

  13. Distribution of the Most Prevalent Spa Types among Clinical Isolates of Methicillin-Resistant and -Susceptible Staphylococcus aureus around the World: A Review

    Science.gov (United States)

    Asadollahi, Parisa; Farahani, Narges Nodeh; Mirzaii, Mehdi; Khoramrooz, Seyed Sajjad; van Belkum, Alex; Asadollahi, Khairollah; Dadashi, Masoud; Darban-Sarokhalil, Davood

    2018-01-01

    Background: Staphylococcus aureus, a leading cause of community-acquired and nosocomial infections, remains a major health problem worldwide. Molecular typing methods, such as spa typing, are vital for the control and, when typing can be made more timely, prevention of S. aureus spread around healthcare settings. The current study aims to review the literature to report the most common clinical spa types around the world, which is important for epidemiological surveys and nosocomial infection control policies. Methods: A search via PubMed, Google Scholar, Web of Science, Embase, the Cochrane library, and Scopus was conducted for original articles reporting the most prevalent spa types among S. aureus isolates. The search terms were “Staphylococcus aureus, spa typing.” Results: The most prevalent spa types were t032, t008 and t002 in Europe; t037 and t002 in Asia; t008, t002, and t242 in America; t037, t084, and t064 in Africa; and t020 in Australia. In Europe, all the isolates related to spa type t032 were MRSA. In addition, spa type t037 in Africa and t037and t437 in Australia also consisted exclusively of MRSA isolates. Given the fact that more than 95% of the papers we studied originated in the past decade there was no option to study the dynamics of regional clone emergence. Conclusion: This review documents the presence of the most prevalent spa types in countries, continents and worldwide and shows big local differences in clonal distribution. PMID:29487578

  14. Hotel Online Marketing: The Bugibba Hotel, Radisson Blu Resort Malta, St. Julian's, Preluna Hotel & SPA

    OpenAIRE

    Dinh Quynh, Mai

    2013-01-01

    The thesis covers the study of online marketing theory, a very popular trend of marketing nowadays, especially Search Engine Optimization (SEO) and Google Adwords Campaign in the analyses of the online marketing practices of three hotels from different areas and standards in Malta, namely The Bugibba Hotel, Preluna Hotel & SPA and Radisson Blu Resort Malta, St. Julian’s. From the analyses, the thesis aims at suggesting Preluna Hotel & SPA optimal online marketing practices and answering t...

  15. Staphylococcus aureus spa type t437

    DEFF Research Database (Denmark)

    Glasner, C; Pluister, G; Westh, H

    2015-01-01

    Methicillin-resistant Staphylococcus aureus (MRSA) belonging to the multilocus sequence type clonal complex 59 (MLST CC59) is the predominant community-associated MRSA clone in Asia. This clone, which is primarily linked with the spa type t437, has so far only been reported in low numbers among...... included. Most isolates were shown to be monophyletic with 98% of the isolates belonging to the single MLVA complex 621, to which nearly all included isolates from China also belonged. More importantly, all MLST-typed isolates belonged to CC59. Our study implies that the European S. aureus t437 population...

  16. The design of the spa - tourist recreational complex

    Directory of Open Access Journals (Sweden)

    Alenka Fikfak

    2012-01-01

    Full Text Available The study area lies in the central part of Bela Krajina in south-eastern Slovenia, between the town of Črnomelj and the border crossing at Vinica. It is situated in the vicinity of the Lahinja Landscape Park, where natural and cultural heritage sites interact in the interesting settings of preserved towns and villages. The urban planning concept developed at the workshop was based on the idea that the best space is one where the qualities of "empty spaces" and a fusion with the landscape are recognised. The concept was based on the design of a complex with several connecting structures. A green clearing was defined as the centre of activities, i.e. the core of the activity and pivot of life being the common point of all structures: it is empty, intended to allow for random connections, network organisation or spatial networking, where the key points in the built and natural structures are connected, hence representing the main communication hub between the individual structures. The concept complements the system with accommodation capacities, which are also located outside the spa complex, providing attractive accommodation in a natural setting.

  17. Rickett’s Dry Cleaning Site, Village of Ballston Spa, NY

    Science.gov (United States)

    The Rickett’s Dry Cleaning Site is located in a mixed commercial and residential area in the village of Ballston Spa on County Route 50. The site was the location of a family owned dry cleaner/ laundromat that went out of business in 2014. The site has

  18. Effectiveness of balneotherapy and spa therapy for the treatment of chronic low back pain: a review on latest evidence.

    Science.gov (United States)

    Karagülle, Mine; Karagülle, Müfit Zeki

    2015-02-01

    In most European countries, balneotherapy and spa therapy are widely prescribed by physicians and preferred by European citizens for the treatment of musculoskeletal problems including chronic low back pain (LBP). We aimed to review and evaluate the recent evidence on the effectiveness of balneotherapy and spa therapy for patients with LBP. We comprehensively searched data bases for randomized controlled trials (RCTs) published in English between July 2005 and December 2013. We identified all trials testing balneotherapy or spa therapy for LBP that reported that the sequence of allocation was randomized. We finally included total of eight RCTs: two on balneotherapy and six on spa therapy. All reviewed trials reported that balneotherapy was superior in long term to tap water therapy in relieving pain and improving function and that spa therapy combining balneotherapy with mud pack therapy and/or exercise therapy, physiotherapy, and/or education was effective in the management of low back pain and superior or equally effective to the control treatments in short and long terms. We used Jadad scale to grade the methodological quality. Only three out of total eight had a score of above 3 indicating the good quality. The data from the RCTs indicates that overall evidence on effectiveness of balneotherapy and spa therapy in LBP is encouraging and reflects the consistency of previous evidence. However, the overall quality of trials is generally low. Better quality RCTs (well designed, conducted, and reported) are needed testing short- and long-term effects for relieving chronic back pain and proving broader beneficial effects.

  19. Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy.

    Science.gov (United States)

    Baeten, Dominique; Kruithof, Elli; De Rycke, Leen; Boots, Anemieke M; Mielants, Herman; Veys, Eric M; De Keyser, Filip

    2005-01-01

    Considering the relation between synovial inflammation and global disease activity in rheumatoid arthritis (RA) and the distinct but heterogeneous histology of spondyloarthropathy (SpA) synovitis, the present study analyzed whether histopathological features of synovium reflect specific phenotypes and/or global disease activity in SpA. Synovial biopsies obtained from 99 SpA and 86 RA patients with active knee synovitis were analyzed for 15 histological and immunohistochemical markers. Correlations with swollen joint count, serum C-reactive protein concentrations, and erythrocyte sedimentation rate were analyzed using classical and multiparameter statistics. SpA synovitis was characterized by higher vascularity and infiltration with CD163+ macrophages and polymorphonuclear leukocytes (PMNs) and by lower values for lining-layer hyperplasia, lymphoid aggregates, CD1a+ cells, intracellular citrullinated proteins, and MHC-HC gp39 complexes than RA synovitis. Unsupervised clustering of the SpA samples based on synovial features identified two separate clusters that both contained different SpA subtypes but were significantly differentiated by concentration of C-reactive protein and erythrocyte sedimentation rate. Global disease activity in SpA correlated significantly with lining-layer hyperplasia as well as with inflammatory infiltration with macrophages, especially the CD163+ subset, and with PMNs. Accordingly, supervised clustering using these synovial parameters identified a cluster of 20 SpA patients with significantly higher disease activity, and this finding was confirmed in an independent SpA cohort. However, multiparameter models based on synovial histopathology were relatively poor predictors of disease activity in individual patients. In conclusion, these data indicate that inflammatory infiltration of the synovium with CD163+ macrophages and PMNs as well as lining-layer hyperplasia reflect global disease activity in SpA, independently of the SpA subtype

  20. A new silver based composite material for SPA water disinfection.

    Science.gov (United States)

    Tartanson, M A; Soussan, L; Rivallin, M; Chis, C; Penaranda, D; Lapergue, R; Calmels, P; Faur, C

    2014-10-15

    A new composite material based on alumina (Al2O3) modified by two surface nanocoatings - titanium dioxide (TiO2) and silver (Ag) - was studied for spa water disinfection. Regarding the most common microorganisms in bathing waters, two non-pathogenic bacteria Escherichia coli (Gram-negative) and Staphylococcus epidermidis (Gram positive) were selected as surrogates for bacterial contamination. The bactericidal properties of the Al2O3-TiO2-Ag material were demonstrated under various operating conditions encountered in spa water (temperature: 22-37 °C, presence of salt: CaCO3 or CaCl2, high oxygen content, etc.). Total removal of 10(8) CFU mL(-1) of bacteria was obtained in less than 10 min with 16 g L(-1) of material. Best results were observed for both conditions: a temperature of 37 °C and under aerobic condition; this latest favouring Reactive Oxygen Species (ROS) generation. The CaCO3 salt had no impact on the bactericidal activity of the composite material and CaCl2 considerably stabilized the silver desorption from the material surface thanks to the formation of AgCl precipitate. Preliminary tests of the Al2O3-TiO2-Ag bactericidal behaviour in a continuous water flow confirmed that 2 g L(-1) of material eliminated more than 90% of a 2.0 × 10(8) CFU mL(-1) bacterial mixture after one water treatment recycle and reached the disinfection standard recommended by EPA (coliform removal = 6 log) within 22 h. Copyright © 2014 Elsevier Ltd. All rights reserved.

  1. spa typing and antimicrobial resistance of Staphylococcus aureus from healthy humans, pigs and dogs in Tanzania

    DEFF Research Database (Denmark)

    Katakweba, Abdul S.; Muhairwa, Amandus P.; Espinosa-Gongora, Carmen

    2016-01-01

    . aureus carrier frequencies in dogs and humans were within the expected range and low in pigs. The S. aureus spa types circulating in the community were generally not shared by different hosts and majority of types belonged to known clones. Besides ampicillin resistance, moderate levels of antimicrobial......Introduction: Staphylococcus aureus is an opportunistic pathogen causing infections in humans and animals. Here we report for the first time the prevalence of nasal carriage, spa typing and antimicrobial resistance of S. aureus in a Tanzanian livestock community. Methodology: Nasal swabs were taken...... from 100 humans, 100 pigs and 100 dogs in Morogoro Municipal. Each swab was enriched in Mueller Hinton broth with 6.5% NaCl and subcultured on chromogenic agar for S. aureus detection. Presumptive S. aureus colonies were confirmed to the species level by nuc PCR and analysed by spa typing...

  2. 77 FR 27144 - Airworthiness Directives; Agusta S.p.A. Helicopters

    Science.gov (United States)

    2012-05-09

    ... Agusta, S.p.A., Via Giovanni Agusta 520, 21017 Cascina Costa di Samarate (VA), Italy, ATTN: Giovanni... written comments, data, or views. We also invite comments relating to the economic, environmental, energy.... Discussion The European Aviation Safety Agency (EASA), which is the Technical Agent for Italy, a Member State...

  3. SPA Adición de enmiendas a suelos contaminados

    OpenAIRE

    Madejón, Paula

    2016-01-01

    SPA Adición de enmiendas a suelos contaminados.-- Información introducida en la base de datos WOCAT es una red global de gestión sostenible de tierras (SLM) que promueve la documentación, el intercambio y el uso del conocimiento para apoyar la adaptación, la innovación y la toma de decisiones en SLM.

  4. Spa therapy together with supervised self-mobilisation improves pain, function and quality of life in patients with chronic shoulder pain: a single-blind randomised controlled trial

    Science.gov (United States)

    Chary-Valckenaere, Isabelle; Loeuille, Damien; Jay, Nicolas; Kohler, François; Tamisier, Jean-Noë; Roques, Christian-François; Boulange, Michel; Gay, Gérard

    2018-06-01

    To determine whether spa therapy has a beneficial effect on pain and disability in patients with chronic shoulder pain, this single-blind randomised controlled clinical trial included patients with chronic shoulder pain due to miscellaneous conditions attending one of four spa centres as outpatients. Patients were randomised into two groups: spa therapy (18 days of standardised treatment combining thermal therapy together with supervised mobilisation in a thermal pool) and controls (spa therapy delayed for 6 months: `immediate versus delayed treatment' paradigm). All patients continued usual treatments during the 6-month follow-up period. The main endpoint was the mean change in the French-Quick DASH (F-QD) score at 6 months. The effect size of spa therapy was calculated, and the proportion of patients reaching minimal clinically important improvement (MCII) was compared. Secondary endpoints were the mean change in SF-36, treatment use and tolerance. One hundred eighty-six patients were included (94 patients as controls, 92 in the spa group) and analysed by intention to treat. At 6 months, the mean change in the F-QD score was statistically significantly greater among spa therapy patients than controls (- 32.6 versus - 8.15%; p < 0.001) with an effect size of 1.32 (95%CI: 0.97-1.68). A significantly greater proportion of spa therapy patients reached MCII (59.3 versus 17.9%). Spa therapy was well tolerated with a significant impact on SF-36 components but not on drug intake. Spa therapy provided a statistically significant benefit on pain, function and quality of life in patients with chronic shoulder pain after 6 months compared with usual care.

  5. Local and spa fee on the example of Kujawsko-pomorskie municipalities

    Directory of Open Access Journals (Sweden)

    Robert Kwaśniewski

    2016-12-01

    Full Text Available The article discusses facultative public levies in the Polish tax system – ie. local and spa tax. This publication presents legal structure of both taxes in accordance with the regulations of local taxes and fees contained in the Act of 12 January 1991. It also presents the results of empirical researches that have been carried out in Kujawsko-pomorskie municipalities, where local and spa taxes occured. The basic aim of study was to determine in which municipalities these fees were in force in 2010–2014 and what income had the individual municipal governments. Completed research would answer the question, whether the analysed charges are effective from local government`s point of view. The article is based on the analysis of legal acts, available literature and using case law of administrative courts. Furthermore, the authors presented the results of empirical research taken from Ms. Iwona Majewska thesis.

  6. Biological properties of mud extracts derived from various spa resorts.

    Science.gov (United States)

    Spilioti, Eliana; Vargiami, Margarita; Letsiou, Sophia; Gardikis, Konstantinos; Sygouni, Varvara; Koutsoukos, Petros; Chinou, Ioanna; Kassi, Eva; Moutsatsou, Paraskevi

    2017-08-01

    Spa resorts are known for thousands of years for their healing properties and have been empirically used for the treatment of many inflammatory conditions. Mud is one of the most often used natural materials for preventive, healing and cosmetic reasons and although it has been used since the antiquity, little light has been shed on its physical, chemical and biological properties. In this study we examined the effect of mud extracts on the expression of adhesion molecules (CAMs) by endothelial cells as well as their effects on monocyte adhesion to activated endothelial cells. Most of mud extracts inhibited the expression of VCAM-1 by endothelial cells and reduced monocyte adhesion to activated endothelial cells, indicating a potent anti-inflammatory activity. Furthermore, the mud extracts were tested for their antimicrobial activity; however, most of them appeared inactive against S. aureus and S. epidermidis. One of the mud extracts (showing the best stabilization features) increased significantly the expression of genes involved in cell protection, longevity and hydration of human keratinocytes, such as, collagen 6A1, forkhead box O3, sirtuin-1, superoxide dismutase 1 and aquaporin-3. The present study reveals that mud exerts important beneficial effects including anti-inflammatory and anti-aging activity as well as moisturizing effects, implicating important cosmeceutical applications.

  7. State-wide surveillance of antibiotic resistance patterns and spa types of methicillin-resistant Staphylococcus aureus from blood cultures in North Rhine-Westphalia, 2011-2013.

    Science.gov (United States)

    Cuny, C; Layer, F; Werner, G; Harmsen, D; Daniels-Haardt, I; Jurke, A; Mellmann, A; Witte, W; Köck, R

    2015-08-01

    Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of bacteraemia. We aimed to obtain a complete picture of severe MRSA infections by characterizing all MRSA isolates from bloodstream infections in the largest German federal state (North Rhine-Westphalia, 18 million inhabitants) using S. aureus protein A (spa) sequence-typing and antimicrobial susceptibility testing. MRSA isolates (n = 1952) were collected prospectively (2011-2013) and spa-typed. Among 181 different spa types, t003 (n = 746 isolates; 38.2%) and t032 (n = 594; 30.4%) were predominant. Analysis of the geographical occurrence of spa clonal complexes (spa-CCs) and spa types revealed divergent distribution between federal state districts for spa-CCs 003 (p resistant to fluoroquinolones, 78% to erythromycin, 70% to clindamycin, 4% to gentamicin, 2% to rifampicin, 0.4% to daptomycin, 0.1% to linezolid and 0% to vancomycin, respectively. Vancomycin MICs of 2 mg/L involved 0.5% of the isolates. In conclusion, the detection of regional molecular clusters added valuable information for epidemiological case tracing and allowed conclusions to be reached on the importance of newly emerging MRSA reservoirs, such as livestock (spa-CC011), for MRSA bacteraemia in some parts of the federal state. Susceptibility testing revealed broad resistance to substances used for oral treatment, but demonstrated that those antibiotics that are mostly applied for treatment of MRSA bacteraemia and important combination partners were highly susceptible. Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  8. Spa therapy together with supervised self-mobilisation improves pain, function and quality of life in patients with chronic shoulder pain: a single-blind randomised controlled trial

    Science.gov (United States)

    Chary-Valckenaere, Isabelle; Loeuille, Damien; Jay, Nicolas; Kohler, François; Tamisier, Jean-Noë; Roques, Christian-François; Boulange, Michel; Gay, Gérard

    2018-02-01

    To determine whether spa therapy has a beneficial effect on pain and disability in patients with chronic shoulder pain, this single-blind randomised controlled clinical trial included patients with chronic shoulder pain due to miscellaneous conditions attending one of four spa centres as outpatients. Patients were randomised into two groups: spa therapy (18 days of standardised treatment combining thermal therapy together with supervised mobilisation in a thermal pool) and controls (spa therapy delayed for 6 months: `immediate versus delayed treatment' paradigm). All patients continued usual treatments during the 6-month follow-up period. The main endpoint was the mean change in the French-Quick DASH (F-QD) score at 6 months. The effect size of spa therapy was calculated, and the proportion of patients reaching minimal clinically important improvement (MCII) was compared. Secondary endpoints were the mean change in SF-36, treatment use and tolerance. One hundred eighty-six patients were included (94 patients as controls, 92 in the spa group) and analysed by intention to treat. At 6 months, the mean change in the F-QD score was statistically significantly greater among spa therapy patients than controls (- 32.6 versus - 8.15%; p impact on SF-36 components but not on drug intake. Spa therapy provided a statistically significant benefit on pain, function and quality of life in patients with chronic shoulder pain after 6 months compared with usual care.

  9. What influences buying leisure services coupons on online group buying?

    OpenAIRE

    Langvinienė, Neringa; Zemblytė, Jurgita; Sližienė, Gelminė

    2016-01-01

    Growing use of IT, laptops, tablets, PC in individuals' life shaped an opportunity to create online group buying (OGB) as a new online business model. Several of surveys show that OGB is rather popular for selling recreational activities and leisure services, such as restaurant coupons, cinema, spa, concert, flight tickets, museum visits, etc. Therefore, the paper aims to identify and estimate the influences that affect the customers to purchase the leisure services coupons on online group bu...

  10. Enhanced discrimination of highly clonal ST22-methicillin-resistant Staphylococcus aureus IV isolates achieved by combining spa, dru, and pulsed-field gel electrophoresis typing data.

    LENUS (Irish Health Repository)

    Shore, Anna C

    2010-05-01

    ST22-methicillin-resistant Staphylococcus aureus type IV (ST22-MRSA-IV) is endemic in Irish hospitals and is designated antibiogram-resistogram type-pulsed-field group (AR-PFG) 06-01. Isolates of this highly clonal strain exhibit limited numbers of pulsed-field gel electrophoresis (PFGE) patterns and spa types. This study investigated whether combining PFGE and spa typing with DNA sequencing of the staphylococcal cassette chromosome mec element (SCCmec)-associated direct repeat unit (dru typing) would improve isolate discrimination. A total of 173 MRSA isolates recovered in one Irish hospital during periods in 2007 and 2008 were investigated using antibiogram-resistogram (AR), PFGE, spa, dru, and SCCmec typing. Isolates representative of each of the 17 pulsed-field group 01 (PFG-01) spa types identified underwent multilocus sequence typing, and all isolates were ST22. Ninety-seven percent of isolates (168 of 173) exhibited AR-PFG 06-01 or closely related AR patterns, and 163 of these isolates harbored SCCmec type IVh. The combination of PFGE, spa, and dru typing methods significantly improved discrimination of the 168 PFG-01 isolates, yielding 65 type combinations with a Simpson\\'s index of diversity (SID) of 96.53, compared to (i) pairwise combinations of spa and dru typing, spa and PFGE typing, and dru and PFGE typing, which yielded 37, 44, and 43 type combinations with SIDs of 90.84, 91.00, and 93.57, respectively, or (ii) individual spa, dru, and PFGE typing methods, which yielded 17, 17, and 21 types with SIDs of 66.9, 77.83, and 81.34, respectively. Analysis of epidemiological information for a subset of PFG-01 isolates validated the relationships inferred using combined PFGE, spa, and dru typing data. This approach significantly enhances discrimination of ST22-MRSA-IV isolates and could be applied to epidemiological investigations of other highly clonal MRSA strains.

  11. [The impact of the spa therapy on reduction of the perception of pain intensity in patients with degenerative joints and disc disease].

    Science.gov (United States)

    Kuciel-Lewandowska, Jadwiga; Paprocka-Borowicz, Małgorzata

    2015-01-01

    Degenerative joints and disc disease is accompanied by chronic pain which is the main symptom of the disease. Medical spa therapy has the task of providing comprehensive treatment embracing diseases of limbs as well as other systems and the essential role of medical treatment, in particular spa therapy, is pain relief. The aim of the study was to evaluate the effect of the spa treatment on the level of pain perception in patients with degenerative joints and disc disease. The observation embraced 120 people with degenerative joints and disc disease treated in the spa. The study included a comprehensive therapy conducted over a 21-day stays at the spa Przerzeczyn-Zdrój with the application of selected physical treatments, physiotherapy and the use of therapeutic natural resources: peloid mud and healing radon-sulphide water. Moreover, there was psychological counseling and health education conducted. The study also included observation of 21 persons from the control group. However, the patients in the control group did not benefit from balneotherapy, psychological care and education. There was a standard VAS scale for pain and non-standard questionnaire of pain assessment constructed for the study purposes. The assessment of pain using the VAS scale and questionnaire of pain assessment both in the study group and the control group were performed before and after the treatment. The results were analyzed statistically, there was Statistica program in Polish version used. In the analysis of the obtained results there were two tests scheduled: the sign test, the Wilcoxon test and descriptive statistics. As a result of the spa therapy and treatments administered on an outpatient basis there was reduction of pain intensity observed. 1. Spa therapy and outpatient treatment reduce the level of pain in patients with degenerative joints and disc disease. 2. The reduction of pain level was more effective in case of therapy conducted in the spa.

  12. Pulling Marbles from a Bag: Deducing the Regional Impact History of the SPA Basin from Impact-Melt Rocks

    Science.gov (United States)

    Cohen, Barbara A.; Coker, Robert F.

    2010-01-01

    The South Pole Aitken (SPA) basin is the stratigraphically oldest identifiable lunar basin and is therefore one of the most important targets for absolute age-dating to help understand whether ancient lunar bombardment history smoothly declined or was punctuated by a cataclysm. A feasible near-term approach to this problem is to robotically collect a sample from near the center of the basin, where vertical and lateral mixing provided by post-basin impacts ensures that such a sample will be composed of small rock fragments from SPA itself, from local impact craters, and from faraway giant basins. The range of ages, intermediate spikes in the age distribution, and the oldest ages are all part of the definition of the absolute age and impact history recorded within the SPA basin.

  13. Real-life effectiveness of spa therapy in rheumatic and musculoskeletal diseases: a retrospective study of 819 patients

    Science.gov (United States)

    Karagülle, Mine; Kardeş, Sinan; Karagülle, Müfit Zeki

    2017-11-01

    The objective of this study is to determine the use and efficacy of spa therapy in patients with a wide spectrum of rheumatic and musculoskeletal diseases under real-life clinical practice circumstances. In this retrospective observational study at the Medical Ecology and Hydroclimatology Department of Istanbul Faculty of Medicine, the records of all adult patients with rheumatic and musculoskeletal diseases who were prescribed a spa therapy in various health resorts in Turkey between 2002 and 2012 were analyzed. Patients sojourned to and stayed at a health resort and followed a usual 2-week course of spa therapy. The patients were examined within a week before and after the spa therapy at the department by the physicians and outcome measures were pain intensity (visual analog scale, VAS), patient's general evaluation (VAS), physician's general evaluation (VAS), Health Assessment Questionnaire (HAQ), Lequesne's Functional Index (LFI), Western Ontario and McMaster Universities Index (WOMAC), Waddell Index (WI), Neck Pain and Disability Scale (NPDS), Shoulder Disability Questionnaire (SDQ), Fibromyalgia Impact Questionnaire (FIQ), and Beck's Depression Inventory (BDI). In total, 819 patients were included in the analysis. The diagnoses were 536 osteoarthritis; 115 fibromyalgia; 50 lumbar disc herniation; 34 cervical disc herniation; 23 nonspecific low back pain; 22 ankylosing spondylitis; 16 rheumatoid arthritis; 9 rotator cuff tendinitis; and 14 other conditions/diseases including scoliosis, stenosing flexor tenosynovitis, congenital hip dislocation in adult, Behçet's disease, de Quervain tendinopathy, psoriatic arthritis, osteoporosis, fracture rehabilitation, and diffuse idiopathic skeletal hyperostosis. Statistically significant decrease in pain scores was found in all patients except hip osteoarthritis ( p = 0.063) and rheumatoid arthritis ( p = 0.134) subgroups; and statistically significant improvement in function in all patients except hip osteoarthritis ( p

  14. Effects of Rusanda Spa balneotherapy combined with calcipotriol on plaque psoriasis.

    Science.gov (United States)

    Golusin, Zoran; Jovanović, Marina; Magda, Natasa; Stojanović, Slobodan; Matić, Milan; Petrović, Aleksandra

    2015-11-01

    Treatment of psoriasis is very complex and there are no still universal, nor unique treatment modalities. Apart from conventional treatment, which includes topical calcipotriol (vitamin D3 analogue), balneotherapy is drawing increased attention worldwide. Being part of climatotherapy, balneotherapy is defined as the use of natural environmental factors in the treatment of health conditions, whereas in the treatment of psoriasis it means the use of mineral baths and peloids. The aim of this study was to examine the therapeutic efficacy of mineral waters and peloids of the Rusanda Spa on plaque psoriasis in patients also treated with calcipotriol. The study included 60 patients divided into two groups. The first group included patients treated with mineral waters, peloids and calcipotriol in the Rusanda Spa, while the second one included those treated only with calcipotriol. The study took 21 days, and each patient was followed up for at least one month after ending the treatment. The treatment efficacy was measured by psoriasis area severity index (PASI) scores on the days 0, 7, 14 and 21 during the treatment and 30 after the end of the therapy. After a 3-week treatment in the Rusanda Spa, the first group showed a decrease in PASI score by 59.45%, whereas in the group of outpatients treated by calcipotriol it was 39.34%. On the day 30 following the treatment, the first group presented with the PASI score reduction of 58.44%, and the second group of 34.78%. The therapeutic efficacy of mineral waters and peloids combined with calcipotriol showed to be significantly higher in regard to monotherapy with calcipotriol (p balneotherapy as monotherapy in treatment of this type of psoriasis.

  15. Analysis of the radioactivity in the 'Elguea' spa, Villa Clara, Cuba; Analisis de la radiactividad en el balneario 'Elguea' , Villa Clara, Cuba

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez G, I M; Zerquera, J T; Carrazana G, J; Capote F, E; Rodriguez C, G [CPHR, La Habana (Cuba)

    2006-07-01

    The 'Elguea' spa, located in the north coast of the county of Villa Clara, Cuba, is considered one of those more important spas of Latin America. The waters of this spa are rich in salts of chlorine, sodium, bromine, sulfides and its contain radon. As a result of measurements of environmental gamma dose rates carried out in the area of the spa, its were considered levels of dose between 0.13 and 2.3 mSv. The obtained results motivated that it was carried out a characterization, from the radiological point of view, of the spa. This characterization is of supreme importance to be able to evaluate the impact that it has and the discharges of its waters on the environment, as well as, those dose that the population potentially affected can receive by these discharges. With this end its were carried out quantitative determinations of those existent natural more significant radionuclides in different environmental objects coming from the area of the spa and its surroundings, as well as one characterization gamma 'in situ' of the same one. The obtained results are present in this work. (Author)

  16. Kaks kuud Kalev SPA-s / kommenteerinud Julia Kurbat, Natalia Nazarenko-Kiivikas, Margit Lipstuhl

    Index Scriptorium Estoniae

    2012-01-01

    Kahe spordiharrastaja Kaur Sau ja Kadri Sõggeli seatud eesmärkidest 2012. aastal ja kehalisest arengust treenides kaks kuud mõnes Tallinna spordiklubis. Treeningutest Kalev Spa Hotel & Water Park'i nimekandvas spordi- ja vabaajakeskuses

  17. Spa therapy and balneotherapy for treating low back pain: meta-analysis of randomized trials.

    Science.gov (United States)

    Pittler, M H; Karagülle, M Z; Karagülle, M; Ernst, E

    2006-07-01

    Low back pain is a major public health concern and complementary treatments are frequently used for this condition. The objective of this systematic review and meta-analysis was to assess the evidence for or against the effectiveness of spa therapy and balneotherapy for treating low back pain. Systematic searches were conducted on Medline, Embase, Amed Cochrane Central, the UK National Research Register and ClincalTrials.gov (all until July 2005). Hand searches were performed and experts contacted. Methodological quality was assessed using a standard scale. Five randomized clinical trials met all inclusion criteria. Quantitative data synthesis was performed. The data for spa therapy, assessed on a 100 mm visual analogue scale (VAS), suggest significant beneficial effects compared with waiting list control groups (weighted mean difference 26.6 mm, 95% confidence interval 20.4-32.8, n=442) for patients with chronic low back pain. For balneotherapy the data, assessed on a 100 mm VAS, also suggest beneficial effects compared with control groups (weighted mean difference 18.8 mm, 95% confidence interval 10.3-27.3, n=138). Even though the data are scarce, there is encouraging evidence suggesting that spa therapy and balneotherapy may be effective for treating patients with low back pain. These data are not compelling but warrant rigorous large-scale trials.

  18. Actividad Físico - Deportiva en Adolescentes Consumidores de SPA

    OpenAIRE

    Tarqui Silva, Leonardo Eliecer; Universidad Estatal de Milagro - Guayaquil Ecuador

    2017-01-01

    RESUMEN El presente estudio muestra el abordaje terapéutico fundamentado en actividades físico-deportivas aplicadas como reforzador, canalizador y modificador conductual en conjunto con terapias cognitivas, socio-humanísticas, espirituales, ocupacionales, vivenciales y familiares ejecutadas en adolescentes consumidores de sustancias psicoactivas (SPA) entre las edades de 14 a 17 años en la Comunidad Terapéutica para Adolescentes Varones Hogar Crecer (CTHC), de la ciudad de Cuenca - Ecuador; o...

  19. Actividad Físico - Deportiva en Adolescentes Consumidores de SPA

    OpenAIRE

    Tarqui Silva, Leonardo Eliecer

    2017-01-01

    RESUMEN El presente estudio muestra el abordaje terapéutico fundamentado en actividades físico-deportivas aplicadas como reforzador, canalizador y modificador conductual en conjunto con terapias cognitivas, socio-humanísticas, espirituales, ocupacionales, vivenciales y familiares ejecutadas en adolescentes consumidores de sustancias psicoactivas (SPA) entre las edades de 14 a 17 años en la Comunidad Terapéutica para Adolescentes Varones Hogar Crecer (CTHC), de la ciudad de Cuenca - Ecuador; o...

  20. Clinical researches on the efficacy of spa therapy in fibromyalgia: a systematic review

    Directory of Open Access Journals (Sweden)

    Antonio Fraioli

    2013-06-01

    Full Text Available BACKGROUND: Fibromyalgia is characterized by chronic widespread pain, tenderness at muscle and tendon insertions point when digital pressure is applied, sleep disorders, chronic fatigue, depressive episodes, anxiety, and other functional somatic syndromes. OBJECTIVE: The aim of this study was to determine whether balneotherapy with mineral waters and mineral-water containing mud is effective in the management of fibromyalgia. METHODS: We conducted a systematic review of the literature regarding spa therapy in the treatment of the fibromyalgia. We searched many databases for articles published between 2000 and 2012 and we selected 7 studies among 65 articles retrieved. A total of 142 patients received balneotherapy and 129 were controls. CONCLUSIONS: Study data confirms that spa therapy could improve the symptoms of fibromyalgia including pain, depression and minor symptoms.

  1. Transmission of Staphylococcus aureus from maternity unit staff members to newborns disclosed through spa typing.

    Science.gov (United States)

    Matussek, Andreas; Taipalensuu, Jan; Einemo, Ing-Marie; Tiefenthal, Malena; Löfgren, Sture

    2007-03-01

    We observed previously that newborn infants are colonized with Staphylococcus aureus, even if their mothers do not carry S aureus. This observation indicated a cross colonization, and, thus, a risk for nosocomial infection, although the infants are roomed in with their mothers. The S aureus colonization of infants, their parents, and staff members was measured at 3 maternity units. Possible transmission routes were determined using spa typing of S aureus isolates. Infants had the highest S aureus carriage (45%) compared with fathers (39%), mothers (27%), and staff members (27%). In 13 out of 44 colonized infants, transmission from staff members was indicated. This transmission was more frequent than was transmission from their own parents (11 cases), and occurred even in cases when parents were colonized with S aureus of other spa types. We confirm a high level of transmission of S aureus from staff members to infants, indicating a risk for patient safety, which necessitates continuing work with implementing scientific evidence for infection control. The spa typing is a rapid and valuable epidemiological tool, and it can be used in improving hospital hygiene control programs.

  2. Quantitative Expression Analysis of SpA, FnbA and Rsp Genes in Staphylococcus aureus: Actively Associated in the Formation of Biofilms.

    Science.gov (United States)

    Yeswanth, Sthanikam; Chaudhury, Abhijit; Sarma, Potukuchi Venkata Gurunadha Krishna

    2017-12-01

    In Staphylococcus aureus, adherence and secretory proteins play chief role in the formation of biofilms. This mode of growth exhibits resistance to a variety of antibiotics and spreads its infections. In the present study, secretary and adherence proteins, Protein-A, Fibronectin-binding protein-A (FnbA) and Rsp (a transcription regulator encoding proteolytic property) expression levels were evaluated at different stages of growth in S. aureus ATCC12600 a drug-sensitive strain and multidrug-resistant strains of S. aureus. Initially, the SpA, FnbA and Rsp genes of S. aureus ATCC12600 were cloned, sequenced, expressed and characterized. The proteolytic property of recombinant Rsp was conspicuously shown when this pathogen was grown in aerobic conditions correlating with reduced biofilm units. In anaerobic mode of growth, S. aureus exhibited a higher expression of SpA and FnbA in early and mid adherence phases and finally stabilized at 48 h of incubation. This expression was more pronounced in methicillin-resistant strains (LMV1-8 and D1-4) of S. aureus. In all these stages, Rsp gene expression was at the lowest level and these results concur with the increased biofilm units. The results of the present study explain proteins chiefly contribute in the formation of biofilms.

  3. 78 FR 69600 - Airworthiness Directives; Piaggio Aero Industries S.p.A Airplanes

    Science.gov (United States)

    2013-11-20

    ... p.m., Monday through Friday, except Federal holidays. For service information identified in this.... To address this potential unsafe condition, Piaggio Aero Industries (PAI) issued Service [[Page 69601... Service Information Piaggio Aero Industries S.p.A. has issued Mandatory Service Bulletin No.: 80-0381, Rev...

  4. A spindle pole antigen gene MoSPA2 is important for polar cell growth of vegetative hyphae and conidia, but is dispensable for pathogenicity in Magnaporthe oryzae.

    Science.gov (United States)

    Li, Chao; Yang, Jun; Zhou, Wei; Chen, Xiao-Lin; Huang, Jin-Guang; Cheng, Zhi-Hua; Zhao, Wen-Sheng; Zhang, Yan; Peng, You-Liang

    2014-11-01

    Spa2 is an important component of the multiprotein complex polarisome, which is involved in the establishment, maintenance, termination of polarized cell growth and is important for defining tip growth of filamentous fungi. In this study, we isolated an insertional mutant of the rice blast fungus Magnaporthe oryzae that formed smaller colony and conidia compared with the wild type. In the mutant, a spindle pole antigen gene MoSPA2 was disrupted by the integration of an exogenous plasmid. Targeted gene deletion and complementation assays demonstrated the gene disruption was responsible for the defects of the insertional mutant. Interestingly, the MoSpa2-GFP fusion protein was found to accumulate as a spot at hyphal tips, septa of hyphae and conidial tip cells where germ tubes are usually produced, but not in appressoria, infection hyphae or at the septa of conidia. Furthermore, the deletion mutants of MoSPA2 exhibited slower hyphal tip growth, more hyphal branches, and smaller size of conidial tip cells. However, MoSPA2 is not required for plant infection. These results indicate that MoSPA2 is required for vegetative hyphal growth and maintaining conidium morphology and that spotted accumulation of MoSpa2 is important for its functions during cell polar growth.

  5. [Certain medico-economic prerequisites for the integration of spa and resort facilities into the system of compulsory health insurance].

    Science.gov (United States)

    Artem'eva, G B; Gekht, I A

    2013-01-01

    The involvement of spa and resort facilities in the system of compulsory health insurance is of primary importance for the improvement of medical aid provided to the population. The application of the methods for the calculation of differential expenditures on the spa and resort-based treatment and estimation of their dependence on a variety of factors may facilitate the more rational use of the available resources of compulsory health insurance.

  6. Study of spa and geology in Nagano pref

    Energy Technology Data Exchange (ETDEWEB)

    Iijima, Namio

    1987-03-20

    After due consideration of magma activities, spars and the horizontal movement involved in the formation of the Japanese Archipelago, magma generation and plate theory under the Japanese Archipelago were studied comprehensively. Many spars in the Japanese North Alpine mountains, which are located in old rock areas, were mainly gushed out from new-period granite. Thus, they were presumed to be caused by volcanos from Hakuba-Norikura to Ontake. There are also several spas on the Central Upheaval Zone which are new lock area spas. This zone is characterized by focused volcanism which occurred during the time from the Tertiary period to the Quaternary period of the diluival epoch. Especially, the northern part of the zone has many high-temperature spas above 50/sup 0/C. Moreover, at the southern end of this zone, special geological features which prove that the Philippine plate and the Pacific plate are sunk under the Japanese Archipelago were found. It was also estimated that Nagano Prefecture has no spa caused by volcanism of acidic plutonic rocks from the the later Mesozoic era to the early Cenozoic era. (3 figs, 1 tab, 27 refs)

  7. [Estimation of effective doses derived from radon in selected SPA centers that use geothermal waters based on the information of radon concentrations].

    Science.gov (United States)

    Walczak, Katarzyna; Zmyślony, Marek

    2013-01-01

    Geothermal waters contain, among other components, soluble radon gas. Alpha radioactive radon is a health hazard to humans, especially when it gets into the respiratory tract. SPA facilities that use geothermal water can be a source of an increased radiation dose to people who stay there. Based on the available literature concerning radon concentrations, we assessed exposure to radon among people - workers and visitors of Spa centers that use geothermal waters. Radon concentrations were analyzed in 17 geothermal centers: in Greece (3 centers), Iran (5), China (4) and India (5). Doses recived by people in the SPA were estimated using the formula that 1 hour exposure to 1 Bq/m3 of radon concentration and equilibrium factor F = 0.4 corresponds to an effective dose of 3.2 nSv. We have found that radon levels in SPAs are from a few to several times higher than those in confined spaces, where geothermal waters are not used (e.g., residential buildings). In 82% of the analyzed SPAs, workers may receive doses above 1 mSv/year. According to the relevant Polish regulations, people receiving doses higher than 1 mSv/year are included in category B of radiation exposure and require regular dosimetric monitoring. Doses received by SPA visitors are much lower because the time of their exposure to radon released from geothermal water is rather short. The analysis of radon concentration in SPA facilities shows that the radiological protection of people working with geothermal waters plays an important role. It seems reasonable to include SPA workers staying close to geotermal waters into a dosimetric monitoring program.

  8. Expression, purification, crystallization and preliminary crystallographic analysis of SpaA, a major pilin from Corynebacterium diphtheriae

    International Nuclear Information System (INIS)

    Kang, Hae Joo; Paterson, Neil G.; Baker, Edward N.

    2009-01-01

    SpaA, one of the major pilins of C. diphtheriae, has been expressed, purified and crystallized and X-ray diffraction data have been collected to 1.6 Å resolution. Bacterial pili are cell-surface organelles that are critically involved in adhesion to host cells, leading to the colonization of host tissues and the establishment of infections. Whereas the pili of Gram-negative bacteria have been extensively studied, those of Gram-positive bacteria came to light only recently after the discovery and characterization of Corynebacterium diphtheriae pili. These newly discovered pili are formed by the covalent polymerization of pilin subunits catalyzed by sortase enzymes, making them fundamentally different from the noncovalent pilin assemblies of Gram-negative bacteria. Here, the expression, crystallization and preliminary crystallographic analysis of SpaA, which forms the shaft of one of the three types of pili expressed by C. diphtheriae, are reported. SpaA 53–486 crystals diffracted to 1.6 Å resolution and belonged to space group P2 1 2 1 2 1 , with unit-cell parameters a = 34.9, b = 64.1, c = 198.7 Å, α = β = γ = 90°

  9. 78 FR 36691 - Airworthiness Directives; Piaggio Aero Industries S.p.A Airplanes

    Science.gov (United States)

    2013-06-19

    ...., Washington, DC 20590, between 9 a.m. and 5 p.m., Monday through Friday, except Federal holidays. For service... condition, Piaggio Aero Industries (PAI) issued Service Bulletin (SB) 80-0345 to provide instructions for... in the AD docket. Relevant Service Information Piaggio Aero Industries S.p.A. has issued Mandatory...

  10. Lactobacillus rhamnosus GG and its SpaC pilus adhesin modulate inflammatory responsiveness and TLR-related gene expression in the fetal human gut

    Science.gov (United States)

    Ganguli, Kriston; Collado, Maria Carmen; Rautava, Jaana; Lu, Lei; Satokari, Reetta; von Ossowski, Ingemar; Reunanen, Justus; de Vos, Willem M.; Palva, Airi; Isolauri, Erika; Salminen, Seppo; Walker, W. Allan; Rautava, Samuli

    2015-01-01

    Background Bacterial contact in utero modulates fetal and neonatal immune responses. Maternal probiotic supplementation reduces the risk of immune-mediated disease in the infant. We investigated the immunomodulatory properties of live Lactobacillus rhamnosus GG and its SpaC pilus adhesin in human fetal intestinal models. Methods TNF-α mRNA expression was measured by qPCR in a human fetal intestinal organ culture model exposed to live L. rhamnosus GG and proinflammatory stimuli. Binding of recombinant SpaC pilus protein to intestinal epithelial cells was assessed in human fetal intestinal organ culture and the human fetal intestinal epithelial cell line H4 by immunohistochemistry and immunofluorescence, respectively. TLR-related gene expression in fetal ileal organ culture after exposure to recombinant SpaC was assessed by qPCR. Results Live L. rhamnosus GG significantly attenuates pathogen-induced TNF-α mRNA expression in the human fetal gut. Recombinant SpaC protein was found to adhere to the fetal gut and to modulate varying levels of TLR-related gene expression. Conclusion The human fetal gut is responsive to luminal microbes. L. rhamnosus GG significantly attenuates fetal intestinal inflammatory responses to pathogenic bacteria. The L. rhamnosus GG pilus adhesin SpaC binds to immature human intestinal epithelial cells and directly modulates intestinal epithelial cell innate immune gene expression. PMID:25580735

  11. Thompson’s Spa: The Most Famous Lunch Counter in the World

    Directory of Open Access Journals (Sweden)

    Peter Szende

    2012-09-01

    Full Text Available Thompson’s Spa in Boston was one of the most celebrated restaurant companies in America at the turn of the twentieth century. Founder Charles Eaton was a pioneer in production and service methods, who developed a variety of innovative mechanical systems. This article describes the founding, growth, and eventual decline of the company during the period 1882 to 1968.

  12. Karhunen-Loève-Based Reduced-Complexity Representation of the Mixed-Density Messages in SPA on Factor Graph and Its Impact on BER

    Directory of Open Access Journals (Sweden)

    Prochazka Pavel

    2010-01-01

    Full Text Available The sum product algorithm on factor graphs (FG/SPA is a widely used tool to solve various problems in a wide area of fields. A representation of generally-shaped continuously valued messages in the FG/SPA is commonly solved by a proper parameterization of the messages. Obtaining such a proper parameterization is, however, a crucial problem in general. The paper introduces a systematic procedure for obtaining a scalar message representation with well-defined fidelity criterion in a general FG/SPA. The procedure utilizes a stochastic nature of the messages as they evolve during the FG/SPA processing. A Karhunen-Loève Transform (KLT is used to find a generic canonical message representation which exploits the message stochastic behavior with mean square error (MSE fidelity criterion. We demonstrate the procedure on a range of scenarios including mixture-messages (a digital modulation in phase parametric channel. The proposed systematic procedure achieves equal results as the Fourier parameterization developed especially for this particular class of scenarios.

  13. Estimation of effective doses derived from radon in selected SPA centers that use geothermal waters based on the information of radon concentrations

    Directory of Open Access Journals (Sweden)

    Katarzyna Walczak

    2013-04-01

    Full Text Available Background: Geothermal waters contain, among other components, soluble radon gas. Alpha radioactive radon is a health hazard to humans, especially when it gets into the respiratory tract. SPA facilities that use geothermal water can be a source of an increased radiation dose to people who stay there. Based on the available literature concerning radon concentrations, we assessed exposure to radon among people - workers and visitors of Spa centers that use geothermal waters. Material and Methods: Radon concentrations were analyzed in 17 geothermal centers: in Greece (3 centers, Iran (5, China (4 and India (5. Doses recived by people in the SPA were estimated using the formula that 1 hour exposure to 1 Bq/m3 of radon concentration and equilibrium factor F = 0.4 corresponds to an effective dose of 3.2 nSv. Results: We have found that radon levels in SPAs are from a few to several times higher than those in confined spaces, where geothermal waters are not used (e.g., residential buildings. In 82% of the analyzed SPAs, workers may receive doses above 1 mSv/year. According to the relevant Polish regulations, people receiving doses higher than 1 mSv/year are included in category B of radiation exposure and require regular dosimetric monitoring. Doses received by SPA visitors are much lower because the time of their exposure to radon released from geothermal water is rather short. Conclusions: The analysis of radon concentration in SPA facilities shows that the radiological protection of people working with geothermal waters plays an important role. It seems reasonable to include SPA workers staying close to geotermal waters into a dosimetric monitoring program. Med Pr 2013;64(2:193–198

  14. Solar car park in a spa town; Das Solarparkhaus an der Kurpromenade

    Energy Technology Data Exchange (ETDEWEB)

    Ernst, Willi

    2010-11-23

    Bad Lippspringe is the first spa town in the German state of Nordrhein-Westfalen that installed a solar park garage. The roof consists of semistransparent solar modules that ensure daylighting even in the winter season. There are safety nets below the modules to protect cars and persons from injuries in case of glassbreak. (orig.)

  15. 76 FR 60396 - Airworthiness Directives; Piaggio Aero Industries S.p.A. Airplanes

    Science.gov (United States)

    2011-09-29

    ...., Washington, DC 20590, between 9 a.m. and 5 p.m., Monday through Friday, except Federal holidays. For service... on other P.180 aeroplanes, and Piaggio Aero Industries (PAI) had issued Service Bulletin (SB) No. 80... information by examining the MCAI in the AD docket. Relevant Service Information Piaggio Aero Industries S.p.A...

  16. Balneotherapy for atopic dermatitis in children at Comano spa in Trentino, Italy.

    Science.gov (United States)

    Farina, Stefania; Gisondi, Paolo; Zanoni, Mauro; Pace, Manuela; Rizzoli, Laura; Baldo, Ermanno; Girolomoni, Giampiero

    2011-12-01

    No controlled studies have investigated whether balneotherapy is effective in atopic dermatitis (AD). To investigate the efficacy and safety of balneotherapy performed at Comano spa (Trentino, Italy) compared to topical corticosteroids (TCS) in the treatment of AD. This was an open, randomized, clinical trial including 104 children (aged 1-14 years) with mild to moderate AD who were assigned either to balneotherapy (n = 54) or TCS (n = 50) once daily for 2 weeks. AD severity and quality of life were measured using the SCORAD, investigator global assessment (IGA), patients' self global assessment (PSGA), children's dermatology life quality index (CDLQI) and family dermatitis impact questionnaire (FDIQ). Subjective measures were re-evaluated 4 months after the end of therapy. Balneotherapy and TCS resulted in a significant reduction of all parameters at week 2. TCS were more effective than balneotherapy regarding SCORAD (46% ± 7.71 vs 26% ± 9.4, mean ± SD; p balneotherapy compared to those treated with TCS (p Balneotherapy at Comano spa appears to be beneficial in children with mild to moderate AD.

  17. Determination of protective properties of Bardejovske Kuple spa curative waters by rotational viscometry and ABTS assay

    Directory of Open Access Journals (Sweden)

    TOPOLSKA Dominika

    2014-02-01

    Full Text Available Mineral waters from Bardejovske Kupele spa are natural, strongly mineralized, with healing effects. They are classified as hydrocarbonic - containing chloride and sodium - carbonic, cold, hypotonic, with a relatively high boric acid content. Potential anti-oxidative effects of curative waters from Bardejovske Kupele were investigated against the hyaluronan (HA degradation. High-molar-mass HA was exposed to the action of ascorbate and cupric ions, which initiate free-radical chain degradation. Time-dependent changes of dynamic viscosity (h of the HA solutions were monitored by rotational viscometry. The radical scavenging capacity of curative waters was determined by the ABTS assay. Despite a significantly high content of transition metal ions, especially iron, remarkable protective effects of the two curative spa waters were found, namely Alzbeta and Klara. Even though “Alzbeta´s“ iron content was 3.5-fold higher than “Klara´s“, “Alzbeta“ was shown to have better protective properties against the HA degradation compared to “Klara“. Bolus addition of ferric ions to the reaction system instead of the natural iron-containing curative water caused a significant HA degradation. The ABTS decolorization assay revealed that the curative spa waters were proven as poorly effective scavengers of the ABTS·+ cation radical.

  18. 75 FR 12167 - Virginia Graeme Baker Pool and Spa Safety Act; Public Accommodation

    Science.gov (United States)

    2010-03-15

    ... pool or spa that is ``open exclusively to patrons of a hotel or other public accommodations facility... Web site at http://www.cpsc.gov . B. Legal Analysis In adopting a reasonable interpretation of... ``an inn, hotel, motel, or other place of lodging, except for an establishment located within a...

  19. Sensitivity Test of Parameters Influencing Flood Hydrograph Routing with a Diffusion-Wave Distributed using Distributed Hydrological Model, Wet Spa, in Ziarat Watershed

    Directory of Open Access Journals (Sweden)

    narges javidan

    2017-02-01

    Full Text Available Introduction: Flood routing is a procedure to calculate flood stage and water depth along a river or to estimate flood hydrograph at river downstream or at reservoir outlets using the upstream hydrography . In river basins, excess rainfall is routed to the basin outlet using flow routing techniques to generate flow hydrograph. A GIS-based distributed hydrological model, Wet Spa, has been under development suitable for flood prediction and watershed management on a catchment scale. The model predicts outflow hydrographs at the basin outlet or at any converging point in the watershed, and it does so in a user-specified time step. The model is physically based, spatially distributed and time-continuous, and simulates hydrological processes of precipitation, snowmelt, interception, depression, surface runoff, infiltration, evapotranspiration, percolation, interflow, groundwater flow, etc. continuously both in time and space, for which the water and energy balance are maintained on each raster cell. Surface runoff is produced using a modified coefficient method based on the cellular characteristics of slope, land use, and soil type, and allowed to vary with soil moisture, rainfall intensity and storm duration. Interflow is computed based on the Darcy’s law and the kinematic approximation as a function of the effective hydraulic conductivity and the hydraulic gradient, while groundwater flow is estimated with a linear reservoir method on a small subcatchment scale as a function of groundwater storage and a recession coefficient. Special emphasis is given to the overland flow and channel flow routing using the method of linear diffusive wave approximation, which is capable to predict flow discharge at any converging point downstream by a unit response function. The model accounts for spatially distributed hydrological and geophysical characteristics of the catchment. Determination of the river flow hydrograph is a main target in hydrology

  20. Smooth pursuit adaptation (SPA exhibits features useful to compensate changes in the properties of the smooth pursuit eye movement system due to usage.

    Directory of Open Access Journals (Sweden)

    Suryadeep eDash

    2013-10-01

    Full Text Available Smooth-pursuit adaptation (SPA refers to the fact that pursuit gain in the early, still open-loop response phase of the pursuit eye movement can be adjusted based on experience. For instance, if the target moves initially at a constant velocity for approximately 100-200ms and then steps to a higher velocity, subjects learn to up-regulate the pursuit gain associated with the initial target velocity (gain-increase SPA in order to reduce the retinal error resulting from the velocity step. Correspondingly, a step to a lower target velocity leads to a decrease in gain (gain-decrease SPA. In this study we demonstrate that the increase in peak eye velocity during gain-increase SPA is a consequence of expanding the duration of the eye acceleration profile while the decrease in peak velocity during gain-decrease SPA results from reduced peak eye acceleration but unaltered duration. Furthermore, we show that carrying out stereotypical smooth pursuit eye movements elicited by constant velocity target ramps for several hundred trials (= test of pursuit resilience leads to a clear drop in initial peak acceleration, a reflection of oculomotor and/ or cognitive fatigue. However, this drop in acceleration gets compensated by an increase in the duration of the acceleration profile, thereby keeping initial pursuit gain constant. The compensatory expansion of the acceleration profile in the pursuit resilience experiment is reminiscent of the one leading to gain-increase SPA, suggesting that both processes tap one and the same neuronal mechanism warranting a precise acceleration/ duration trade-off. Finally, we show that the ability to adjust acceleration duration during pursuit resilience depends on the integrity of the oculomotor vermis (OMV as indicated by the complete loss of the duration adjustment following a surgical lesion of the OMV in one rhesus monkey we could study.

  1. [Sanatorium-and-spa treatment of children with mucoviscidosis and pancreatic lesions].

    Science.gov (United States)

    Mesropian, S K; Kaĭsinova, A S; Stanilevich, T B; Ter-Akopov, N G

    2010-01-01

    Over 5 years ago, the Yunost' sanatorium, Essentuki, and the Russian Centre of Mucoviscidosis, Moscow, began to jointly implement a rehabilitation program for children with mucoviscidosis. The data obtained made it possible for the first time to propose incorporation of drinking carbonate mineral water in the combined sanatorium-and-spa treatment of such patients. The new method allowed effectiveness of this therapy to be improved by 16-18%.

  2. Clinical and biochemical effects of a 3-week program of diet combined with spa therapy in obese and diabetic patients: a pilot open study

    Science.gov (United States)

    Fioravanti, Antonella; Adamczyk, Przemysław; Pascarelli, Nicola Antonio; Giannitti, Chiara; Urso, Renato; Tołodziecki, Michał; Ponikowska, Irena

    2015-07-01

    Obesity is a major risk factor for arterial hypertension, coronary artery disease, dyslipidemias, and type 2 diabetes. Spa therapy has long been used for treating obesity and its comorbidities. Enlargement of adipose tissue has been linked to a dysregulation of adipokine secretion and adipose tissue inflammation. Adipokines are currently investigated as potential drug targets in these conditions. Our primary aim was to assess the clinical efficacy of a 3-week program of diet combined with spa therapy in obese patients with and without type 2 diabetes. The secondary aim was to examine whether this combined program influences the response of serum levels of leptin, adiponectin, visfatin, and high-sensitivity C-reactive protein. Fifty obese males were enrolled and 21 of these featured a type 2 diabetes. During the 3-week period of the study, the patients were on a 1,000-kcal diet and were involved in mineral bath and total body's mud-pack applications (15 procedures). Patients were assessed at baseline and at the end of the therapy for clinical and biochemical parameters (total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, glycemia, and adipokines). We showed that a 3-week program of spa therapy in obese patients induced significant decrease of body weight, body mass index, triglycerides, total cholesterol, low-density lipoprotein (LDL) cholesterol, glycemia, and serum levels of leptin and high-sensitivity C-reactive protein. So, a cycle of mud-bath therapy associated with a controlled diet may be a promising treatment for obesity and type 2 diabetes decreasing body weight and many risk factors for atherosclerosis and metabolic syndrome.

  3. Effects of age and spa treatment on match running performance over two consecutive games in highly trained young soccer players.

    Science.gov (United States)

    Buchheit, Martin; Horobeanu, Cosmin; Mendez-Villanueva, Alberto; Simpson, Ben M; Bourdon, Pitre C

    2011-03-01

    The aim of this study was to examine the effect of age and spa treatment (i.e. combined sauna, cold water immersion, and jacuzzi) on match running performance over two consecutive matches in highly trained young soccer players. Fifteen pre- (age 12.8 ± 0.6 years) and 13 post- (15.9 ± 1 y) peak height velocity (PHV) players played two matches (Matches 1 and 2) within 48 h against the same opposition, with no specific between-match recovery intervention (control). Five post-PHV players also completed another set of two consecutive matches, with spa treatment implemented after the first match. Match running performance was assessed using a global positioning system with very-high-intensity running (> 16.1-19.0 km · h(-1)), sprinting distance (>19 km · h(-1)), and peak match speed determined. Match 2 very-high-intensity running was "possibly" impaired in post-PHV players (-9 ± 33%; ± 90% confidence limits), whereas it was "very likely" improved for the pre-PHV players (+27 ± 22%). The spa treatment had a beneficial impact on Match 2 running performance, with a "likely" rating for sprinting distance (+30 ± 67%) and "almost certain" for peak match speed (+6.4 ± 3%). The results suggest that spa treatment is an effective recovery intervention for post-PHV players, while its value in pre-PHV players is questionable.

  4. Analysis of the radioactivity in the 'Elguea' spa, Villa Clara, Cuba; Analisis de la radiactividad en el balneario 'Elguea' , Villa Clara, Cuba

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez G, I.M.; Zerquera, J.T.; Carrazana G, J.; Capote F, E.; Rodriguez C, G. [CPHR, La Habana (Cuba)]. e-mail: isis@cphr.edu.cu

    2006-07-01

    The 'Elguea' spa, located in the north coast of the county of Villa Clara, Cuba, is considered one of those more important spas of Latin America. The waters of this spa are rich in salts of chlorine, sodium, bromine, sulfides and its contain radon. As a result of measurements of environmental gamma dose rates carried out in the area of the spa, its were considered levels of dose between 0.13 and 2.3 mSv. The obtained results motivated that it was carried out a characterization, from the radiological point of view, of the spa. This characterization is of supreme importance to be able to evaluate the impact that it has and the discharges of its waters on the environment, as well as, those dose that the population potentially affected can receive by these discharges. With this end its were carried out quantitative determinations of those existent natural more significant radionuclides in different environmental objects coming from the area of the spa and its surroundings, as well as one characterization gamma 'in situ' of the same one. The obtained results are present in this work. (Author)

  5. Cost-effectiveness of Spa treatment for fibromyalgia: general health improvement is not for free

    NARCIS (Netherlands)

    Zijlstra, T.R.; Braakman-Jansen, Louise Marie Antoinette; Taal, Erik; Rasker, Johannes J.; van de Laar, Mart A F J

    2007-01-01

    Objectives: To estimate the cost-effectiveness of an adjuvant treatment course of spa treatment compared with usual care only in patients with fibromyalgia syndrome (FM). - Methods: 134 patients with FM, selected from a rheumatology outpatient department and from members of the Dutch FM patient

  6. The Present and Future of Szigetvár Spa – An Economic Analysis of Geothermal Energy Investment

    Directory of Open Access Journals (Sweden)

    Judit Pálné Schreiner

    2014-09-01

    Full Text Available In Hungary, geothermal energy has proved to be an economical source of energy for direct use. It highlights the pros and cons of including renewable energy in the power generation mix of Hungary, and the pros and cons of local application. This paper looks at the operation of Szigetvár Spa from both economic and social aspects. In this study, qualitative analysis is used for the basic economic and social introduction of the Spa, and then real options, based on quantitative methods, are described to identify the long-term financial consequences of the project. In 1966, thermal water was found in Szigetvár. In 1997, this thermal water was certified as medicinal water. The wellhead temperature of Szigetvár thermal water is 62°C in the 790 metres deep thermal well. It is used as so-called domestic hot water in the Szent István housing estate and in Szigetvár Spa. One of the problems with the project is that it is based on single stage thermal water utilization, another problem is that the waste water is too hot. This can be solved by exploiting the heat energy of thermal water more intensively. This way, maximum benefits can be gained from geothermal energy with minimum use of energy. Static and dynamic investment analyses were carried out to examine the spa from a financial aspect. The methods used include static payback period, average rate of return, levelized cost of electricity, net present value, profitability index, dynamic payback period, internal rate of return and real options. By pricing geothermal technology, it is possible to identify the strategic value of flexibility, to quantify what was previously left unquantified, and thus to show that geothermal investments are profitable not only from a social but also from a financial aspect as well.

  7. Teaching Cultural Astronomy: On the Development and Evolution of the Syllabus at Bath Spa University and the University of Wales, Lampeter

    Science.gov (United States)

    Campion, Nick

    TheMaster of Arts in CulturalAstronomy andAstrology at the University of Wales, Lampeter, formerly taught at Bath Spa University in England, is the first degree of its kind in the world. (I shall refer to the discipline as Cultural Astronomy, with initial letters as upper case, and the phenomena which it studies as cultural astronomy, all lower case). My definition combines both the discipline and the phenomenon; 'Cultural astronomy: the use of astronomical knowledge, beliefs or theories to inspire, inform or influence social forms and ideologies, or any aspect of human behaviour. Cultural astronomy also includes the modern disciplines of ethnoastronomy and archaeoastronomy' (Campion 1997: 2).

  8. Effects of voluntary exercise on spontaneous physical activity and food consumption in mice: Results from an artificial selection experiment.

    Science.gov (United States)

    Copes, Lynn E; Schutz, Heidi; Dlugosz, Elizabeth M; Acosta, Wendy; Chappell, Mark A; Garland, Theodore

    2015-10-01

    We evaluated the effect of voluntary exercise on spontaneous physical activity (SPA) and food consumption in mice from 4 replicate lines bred for 57 generations for high voluntary wheel running (HR) and from 4 non-selected control (C) lines. Beginning at ~24 days of age, mice were housed in standard cages or in cages with attached wheels. Wheel activity and SPA were monitored in 1-min intervals. Data from the 8th week of the experiment were analyzed because mice were sexually mature and had plateaued in body mass, weekly wheel running distance, SPA, and food consumption. Body mass, length, and masses of the retroperitoneal fat pad, liver, and heart were recorded after the 13th week. SPA of both HR and C mice decreased with wheel access, due to reductions in both duration and average intensity of SPA. However, total activity duration (SPA+wheel running; min/day) was ~1/3 greater when mice were housed with wheels, and food consumption was significantly increased. Overall, food consumption in both HR and C mice was more strongly affected by wheel running than by SPA. Duration of wheel running had a stronger effect than average speed, but the opposite was true for SPA. With body mass as a covariate, chronic wheel access significantly reduced fat pad mass and increased heart mass in both HR and C mice. Given that both HR and C mice housed with wheels had increased food consumption, the energetic cost of wheel running was not fully compensated by concomitant reductions in SPA. The experiment demonstrates that both duration and intensity of both wheel running and SPA were significant predictors of food consumption. This sort of detailed analysis of the effects of different aspects of physical activity on food consumption has not previously been reported for a non-human animal, and it sets the stage for longitudinal examination of energy balance and its components in rodent models. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. Diagnosis of the socionic temperament of personality and creating a psychological portrait of the Western European SPA and wellness tourists in Bulgaria

    Science.gov (United States)

    Stoyanova, Milena

    2017-03-01

    Human personality is a set of psychological characteristics that distinguishes it from others. However people can be classified as congenital personality types, interactions that are precisely defined. The aim of this article is to characterize the socionic temperament and psychological profile of the spa and wellness tourists in Bulgaria. The study is based on a survey of 460 tourists who visited Bulgarian spa centers in the summer and autumn of 2015.

  10. The effects of balance and postural stability exercises on spa based rehabilitation programme in patients with ankylosing spondylitis.

    Science.gov (United States)

    Gunay, Selim M; Keser, Ilke; Bicer, Zemzem T

    2018-01-01

    Ankylosing spondylitis (AS) can cause severe functional disorders that lead to loss of balance. The aim of this study was to investigate the effects of balance and postural stability exercises on spa based rehabilitation programme in AS subjects. Twenty-one participants were randomized to the study (n= 11) and control groups (n= 10). Patients balance and stability were assessed with the Berg Balance Scale (BBS), Timed Up and Go (TUG) Test, Single Leg Stance Test (SLST) and Functional Reach Test (FRT). AS spesicied measures were used for assessing to other parameters. The treatment plan for both groups consisted of conventional transcutaneous electrical nerve stimulation (TENS), spa and land-based exercises 5 days per week for 3 weeks. The study group performed exercises based on postural stability and balance with routine physiotherapy practice in thermal water and in exercise room. The TUG, SLST and FUT scores were significantly increased in the study group. In both groups, the BASMI, BASFI, BASDAI and ASQoL scores decreased significantly by the end of the treatment period (pbalance and stability exercises in addition to spa based routine approaches can increase the duration of maintaining balance and can improve the benefits of physiotherapy.

  11. Molecular epidemiology of Staphylococcus aureus bacteremia in a single large Minnesota medical center in 2015 as assessed using MLST, core genome MLST and spa typing.

    Directory of Open Access Journals (Sweden)

    Kyung-Hwa Park

    Full Text Available Staphylococcus aureus is a leading cause of bacteremia in hospitalized patients. Whether or not S. aureus bacteremia (SAB is associated with clonality, implicating potential nosocomial transmission, has not, however, been investigated. Herein, we examined the epidemiology of SAB using whole genome sequencing (WGS. 152 SAB isolates collected over the course of 2015 at a single large Minnesota medical center were studied. Staphylococcus protein A (spa typing was performed by PCR/Sanger sequencing; multilocus sequence typing (MLST and core genome MLST (cgMLST were determined by WGS. Forty-eight isolates (32% were methicillin-resistant S. aureus (MRSA. The isolates encompassed 66 spa types, clustered into 11 spa clonal complexes (CCs and 10 singleton types. 88% of 48 MRSA isolates belonged to spa CC-002 or -008. Methicillin-susceptible S. aureus (MSSA isolates were more genotypically diverse, with 61% distributed across four spa CCs (CC-002, CC-012, CC-008 and CC-084. By MLST, there was 31 sequence types (STs, including 18 divided into 6 CCs and 13 singleton STs. Amongst MSSA isolates, the common MLST clones were CC5 (23%, CC30 (19%, CC8 (15% and CC15 (11%. Common MRSA clones were CC5 (67% and CC8 (25%; there were no MRSA isolates in CC45 or CC30. By cgMLST analysis, there were 9 allelic differences between two isolates, with the remaining 150 isolates differing from each other by over 40 alleles. The two isolates were retroactively epidemiologically linked by medical record review. Overall, cgMLST analysis resulted in higher resolution epidemiological typing than did multilocus sequence or spa typing.

  12. SPA AND CLIMATIC RESORTS (CENTERS AS RESOURCES OF PROGRAM OF SPORT RECREATION IMPLEMENTATION

    Directory of Open Access Journals (Sweden)

    Ivica Nikolić

    2006-06-01

    Full Text Available The aspiration of the civilized man is the improvement of work which aim is to achieve as big as possible effect of productivity and as small as possible participation of labour. The result of this process, which cannot be avoided, is some kind of fatigue that has hypocinaesiological characteristics in regard to demands of modern work process. The most effective way to fight against fatigue is to have an active holiday that is meaningfully programmed, led and carried out through movement of tourists, with the addition of natural factors, among which climate and healing waters are particularly important. These very resources characterize the tourist potential of Serbia and Montenegro with lots of available facilities at 1000 m height above the sea level and spa centers with springs and a complete offer physio-prophylactic procedures and following facilities for sport recreation. The implementation of programmed active holidays in to the corpus of tourist offer of Serbia and Montenegro represents prospective of development of tourism and tourist economy with effects of multiple importance as for participants, so for the level of tourist consumption. That will definitely influence the lengthening of tourist season as the primary goal of every catering establishment. Surveys show that the affection and viewpoints of potential tourists are especially directed towards engaging sport games and activities on and in the water, as part of the elementary tourist offer in spas and climatic resorts and their available facilities. Recommendationsand postulates of program of sport recreation, which are presented through four charts, are the basis of marketing strategy of appearance on tourist market with permanent education of management personnel and further research of potential market expanding. The publication and distribution of advertising materials are especially important, both at the market in our country and at the foreign market, where the abundance

  13. Determination of uranium and polonium in Spa rus aura ta by alpha spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Luna P, M.; Renteria, M.; Montero C, M. E. [Centro de Investigacion en Materiales Avanzados, S. C., Miguel de Cervantes No. 120, Complejo Industrial Chihuahua, 31109 Chihuahua (Mexico); Manjon C, G.; Diaz, I., E-mail: elena.montero@cimav.edu.mx [Universidad de Sevilla, Escuela Tecnica Superior de Arquitectura, Departamento de Fisica Aplicada II, San Fernando No. 4, 41004 Sevilla (Spain)

    2012-06-15

    The aim of this study was optimizing conditions for the specific activities determination of some uranium-series radionuclides present in Spa rus aura ta by alpha spectrometry. Determinations of specific activities were conducted varying the type of digestion: acid attack on hot plate, controlled microwave digestion and acid attack after calcination of the sample. The latter procedure was applied only to the case of uranium isotopes determination. The variation in the isotope extraction method consisted of applying the techniques of liquid-liquid extracting using Tributyl phosphate or chromatographic UTEVA resin. Results depending on the type of treatment given to the samples were compared based on obtained chemical yields. The results reveal a higher bioaccumulation of polonium in the liver sample, with activities of 0.809, 2.495 and 2.439 Bq kg{sup -1} fresh wt compared with the fillet. The best chemical yields of polonium were close to 60% for samples that were digested by microwave. In the case of uranium the best chemical yields, close to 80% for fillet, were obtained with a previous calcination of the sample and using the UTEVA resin. (Author)

  14. Determination of uranium and polonium in Spa rus aura ta by alpha spectrometry

    International Nuclear Information System (INIS)

    Luna P, M.; Renteria, M.; Montero C, M. E.; Manjon C, G.; Diaz, I.

    2012-01-01

    The aim of this study was optimizing conditions for the specific activities determination of some uranium-series radionuclides present in Spa rus aura ta by alpha spectrometry. Determinations of specific activities were conducted varying the type of digestion: acid attack on hot plate, controlled microwave digestion and acid attack after calcination of the sample. The latter procedure was applied only to the case of uranium isotopes determination. The variation in the isotope extraction method consisted of applying the techniques of liquid-liquid extracting using Tributyl phosphate or chromatographic UTEVA resin. Results depending on the type of treatment given to the samples were compared based on obtained chemical yields. The results reveal a higher bioaccumulation of polonium in the liver sample, with activities of 0.809, 2.495 and 2.439 Bq kg -1 fresh wt compared with the fillet. The best chemical yields of polonium were close to 60% for samples that were digested by microwave. In the case of uranium the best chemical yields, close to 80% for fillet, were obtained with a previous calcination of the sample and using the UTEVA resin. (Author)

  15. Performance of scintillation proximity assay (SPA) to measure the level of VEGFR 1 protein

    International Nuclear Information System (INIS)

    LEE, So-Young; LIM, Jae-Cheong; KIM, Jin-Joo

    2014-01-01

    Scintillation proximity assay is a one of radioimmunoassay and can be assayed without the washing or filtration procedures normally used to separate bound from free fractions. Due to its simplicity and high-throughput protocol, it is broadly applicable to immunology, receptor binding, monitoring receptor-ligand interactions and enzyme reactions. Briefly, an antibody or receptor is coated on SPA beads. When a radiolabeled antigen or ligand binds to the beads, the SPA beads stimulate to emit short range electrons. The 3 H and 125 I are commonly used for radiolabeling and the produced photons are detectable with a liquid scintillation counter (LSC). A binding affinity of unlabeled ligands can be determined by competitive reaction of the radiolabeled ligands. Bevacizumab is a recombinant humanized monoclonal antibody, and can stop or delay growth of tumors by inhibiting vascular endothelial growth factor (VEGF). Bevacizumab was approved by FDA for metastatic cancer such as colorectal cancers, ovarian cancers, breast cancers and glioblastoma multiform of the brain. Recently, Dan G. duda et al. was reported that the concentration of vascular endothelial growth factor receptor-1 (VEGFR-1) in plasma may potentially be used as a negative selection biomarker. In this study, we describe a method using scintillation proximity assay to detect the amounts of VEGFR-1 protein. This method is successfully used to measure the concentration of VEGFR-1 protein in human cell extracts. In summary, a simple and sensitive assay is developed for measuring the amount of VEGFR 1 protein in cancer cell lysate using SPA beads. The antibody coating on the beads and antigen binding are achieved in one mixing step

  16. Performance of scintillation proximity assay (SPA) to measure the level of VEGFR 1 protein

    Energy Technology Data Exchange (ETDEWEB)

    LEE, So-Young; LIM, Jae-Cheong; KIM, Jin-Joo [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    Scintillation proximity assay is a one of radioimmunoassay and can be assayed without the washing or filtration procedures normally used to separate bound from free fractions. Due to its simplicity and high-throughput protocol, it is broadly applicable to immunology, receptor binding, monitoring receptor-ligand interactions and enzyme reactions. Briefly, an antibody or receptor is coated on SPA beads. When a radiolabeled antigen or ligand binds to the beads, the SPA beads stimulate to emit short range electrons. The {sup 3}H and {sup 125}I are commonly used for radiolabeling and the produced photons are detectable with a liquid scintillation counter (LSC). A binding affinity of unlabeled ligands can be determined by competitive reaction of the radiolabeled ligands. Bevacizumab is a recombinant humanized monoclonal antibody, and can stop or delay growth of tumors by inhibiting vascular endothelial growth factor (VEGF). Bevacizumab was approved by FDA for metastatic cancer such as colorectal cancers, ovarian cancers, breast cancers and glioblastoma multiform of the brain. Recently, Dan G. duda et al. was reported that the concentration of vascular endothelial growth factor receptor-1 (VEGFR-1) in plasma may potentially be used as a negative selection biomarker. In this study, we describe a method using scintillation proximity assay to detect the amounts of VEGFR-1 protein. This method is successfully used to measure the concentration of VEGFR-1 protein in human cell extracts. In summary, a simple and sensitive assay is developed for measuring the amount of VEGFR 1 protein in cancer cell lysate using SPA beads. The antibody coating on the beads and antigen binding are achieved in one mixing step.

  17. Binding of human collectins (SP-A and MBP) to influenza virus.

    OpenAIRE

    Malhotra, R; Haurum, J S; Thiel, S; Sim, R B

    1994-01-01

    Collectins are a group of soluble proteins each of which has collagenous domains and non-collagenous globular domains, the latter containing the consensus residues found in C-type lectins. Members of the collectin family are the serum proteins mannan-binding protein (MBP), conglutinin, CL-43, and the lung-associated proteins surfactant protein A (SP-A) and surfactant protein D (SP-D). MBP and conglutinin have been shown previously to bind to influenza viruses and to inhibit the infectivity an...

  18. Objectification of a Choice of a Spa Treatment Plan for Arthritis of the Hip Joint

    Czech Academy of Sciences Publication Activity Database

    Och, F.; Medonos, J.; Hanzlíček, P.; Valenta, Zdeněk; Dvořák, V.; Zvárová, Jana

    2013-01-01

    Roč. 1, č. 1 (2013), s. 10-10 ISSN 1805-8698. [EFMI 2013 Special Topic Conference. 17.04.2013-19.04.2013, Prague] Institutional support: RVO:67985807 Keywords : decision-support * spa treatment * hip arthritis * statistical analysis Subject RIV: IN - Informatics, Computer Science

  19. Effect of a steam foot spa on geriatric inpatients with cognitive impairment: a pilot study

    Science.gov (United States)

    Koike, Yoshihisa; Kondo, Hideki; Kondo, Satoshi; Takagi, Masayuki; Kano, Yoshio

    2013-01-01

    Purpose To investigate whether a steam foot spa improves cognitive impairment in geriatric inpatients. Methods Geriatric inpatients with cognitive impairment were given a steam foot spa treatment at 42°C for 20 minutes for 2 weeks (5 days/week). Physiological indicators such as blood pressure, percutaneous oxygen saturation, pulse, tympanic temperature, and sleep time and efficiency were assessed. Cognitive function and behavioral and psychological symptoms of dementia were assessed using the Mini-Mental State Examination, Dementia Mood Assessment Scale, and Dementia Behavior Disturbance scale. Results Significant decreases in systolic (P steam foot spas. A significant improvement was seen in the Mini-Mental State Examination score (P steam foot baths. In this study, a control group was not used. Raters and enforcers were not blinded. Conclusion The results of this pilot study suggest that steam foot spas mitigate cognitive impairment in geriatric inpatients. PMID:23717038

  20. Effect of a steam foot spa on geriatric inpatients with cognitive impairment: a pilot study

    Directory of Open Access Journals (Sweden)

    Koike Y

    2013-05-01

    Full Text Available Yoshihisa Koike,1 Hideki Kondo,2 Satoshi Kondo,1 Masayuki Takagi,1 Yoshio Kano31Department of Occupational Therapy, Prefectural University of Hiroshima, Mihara, Japan; 2Yoshiigawa Hospital, Okayama, Japan; 3Department of Occupational Therapy, Kibi International University, Takahashi, JapanPurpose: To investigate whether a steam foot spa improves cognitive impairment in geriatric inpatients.Methods: Geriatric inpatients with cognitive impairment were given a steam foot spa treatment at 42°C for 20 minutes for 2 weeks (5 days/week. Physiological indicators such as blood pressure, percutaneous oxygen saturation, pulse, tympanic temperature, and sleep time and efficiency were assessed. Cognitive function and behavioral and psychological symptoms of dementia were assessed using the Mini-Mental State Examination, Dementia Mood Assessment Scale, and Dementia Behavior Disturbance scale.Results: Significant decreases in systolic (P < 0.01 and diastolic blood pressure (P < 0.05 along with a significant increase in tympanic temperature (P < 0.01 were observed after the steam foot spas. A significant improvement was seen in the Mini-Mental State Examination score (P < 0.01 and the overall dementia severity items in Dementia Mood Assessment Scale (P < 0.05.Limitations: Japanese people are very fond of foot baths. However, it is difficult to understand why inpatients cannot receive steam foot baths. In this study, a control group was not used. Raters and enforcers were not blinded.Conclusion: The results of this pilot study suggest that steam foot spas mitigate cognitive impairment in geriatric inpatients.Keywords: steam foot spa, geriatric inpatients, cognitive impairment, tympanic temperature

  1. The protective effect of different airway humidification liquids to lung after tracheotomy in traumatic brain injury: The role of pulmonary surfactant protein-A (SP-A).

    Science.gov (United States)

    Su, Xinyang; Li, Zefu; Wang, Meilin; Li, Zhenzhu; Wang, Qingbo; Lu, Wenxian; Li, Xiaoli; Zhou, Youfei; Xu, Hongmei

    2016-02-10

    The purpose of this study was to establish a rat model of a brain injury with tracheotomy and compared the wetting effects of different airway humidification liquids, afterward, the best airway humidification liquid was selected for the clinical trial, thus providing a theoretical basis for selecting a proper airway humidification liquid in a clinical setting. Rats were divided into a sham group, group A (0.9% NaCl), group B (0.45% NaCl), group C (0.9% NaCl+ambroxol) and group D (0.9% NaCl+Pulmicort). An established rat model of traumatic brain injury with tracheotomy was used. Brain tissue samples were taken to determine water content, while lung tissue samples were taken to determine wet/dry weight ratio (W/D), histological changes and expression levels of SP-A mRNA and SP-A protein. 30 patients with brain injury and tracheotomy were selected and divided into two groups based on the airway humidification liquid instilled in the trachea tube, 0.45% NaCl and 0.9% NaCl+ambroxol. Blood was then extracted from the patients to measure the levels of SP-A, interleukin-6 (IL-6), interleukin-8 (IL-8) and tumour necrosis factor-α (TNF-α). The difference between group C and other groups in lung W/D and expression levels of SP-A mRNA and SP-A protein was significant (Phumidification liquid. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. Radiological impact of a spent fuel disposal in a deep geological granite formation - results of the european spa project

    International Nuclear Information System (INIS)

    Baudoin, P.; Gay, D.; Certes, C.; Serres, C.

    2000-01-01

    The SPA project (Spent fuel disposal Performance Assessment) is the latest of four integrated performance assessment exercises on nuclear waste disposal in geological formations, carried out in the framework of the European Community 'Nuclear Fission' Research Programmes. The SPA project, which was undertaken by ENRESA, GRS, IPSN, NRG, SCK.CEN and VTT between May 1996 and April 1999, was devoted to the study of disposal of spent fuel in various host rock formations (clay, crystalline rocks and salt formation). This project is a direct continuation of the efforts made by the European Community since 1982 to build a common understanding of the methods applicable to deep disposal performance assessment. (authors)

  3. 76 FR 27872 - Airworthiness Directives; PIAGGIO AERO INDUSTRIES S.p.A Model P-180 Airplanes

    Science.gov (United States)

    2011-05-13

    ... through Friday, except Federal holidays. For service information identified in this AD, contact Piaggio... accomplishment instructions of Piaggio Aero Industries Alert Service Bulletin ASB- 80-0324, step 5, this AD.... Relevant Service Information PIAGGIO AERO INDUSTRIES S.p.A has issued Service Bulletin (Mandatory) N.: 80...

  4. Structure of Spa15, a type III secretion chaperone from Shigella flexneri with broad specificity

    NARCIS (Netherlands)

    Eerde, André van; Hamiaux, Cyril; Pérez, Javier; Parsot, Claude; Dijkstra, Bauke W.

    2004-01-01

    Type III secretion (TTS) systems are used by many Gram-negative pathogens to inject virulence proteins into the cells of their hosts. Several of these virulence effectors require TTS chaperones that maintain them in a secretion-competent state. Whereas most chaperones bind only one effector, Spa15

  5. Impact of serum SP-A and SP-D levels on comparison and prognosis of idiopathic pulmonary fibrosis

    Science.gov (United States)

    Wang, Kai; Ju, Qing; Cao, Jing; Tang, Wenze; Zhang, Jian

    2017-01-01

    Abstract Background and objective: Idiopathic pulmonary fibrosis (IPF) has a poor prognosis in general; however, it is heterogeneous to detect relative biomarkers for predicting the disease progression. Serum biomarkers can be conveniently collected to detect and help to differentially diagnose IPF and predict IPF prognosis. This meta-analysis aimed to evaluate the use of serum surfactant proteins A and D (SP-A and SP-D) for differential diagnosis and prognosis of IPF. Methods: Relevant articles were searched in PubMed, Embase, and Chinese National Knowledge Infrastructure databases and reviewed by 2 independent readers. Standard mean difference (SMD) and 95% confidence interval (CI) were calculated to assess the difference in serum levels of SP-A/D among patients with IPF, when compared to patients with non-IPF interstitial lung disease (ILD), pulmonary infection, and healthy control. Hazard ratio (HR) and 95% CI were used to compare the relative risk of mortality. Results: Twenty-one articles (totalling 1289 IPF patients) were included in final meta-analysis. Serum SP-A levels were significantly higher in patients with IPF than in patients with non-IPF ILD (SMD: 1.108 [0.584, 1.632], P infection (SMD: 1.320 [0.999, 1.640], P SMD: 2.802 [1.901, 3.702], P SMD: 0.459 [−0.000, 0.919], P = .050). Serum SP-D levels were significantly higher in patients with IPF than in patients with pulmonary infection (SMD: 1.308 [0.813, 1.803], P SMD: 2.235 [1.739, 2.731], P < .001). Risk of death in patients with IPF and elevated serum SP-A was increased 39% compared to patients with low SP-A groups. Elevated SP-D increased risk by 111% when compared to low SP-D. In acute exacerbation of IPF, serum SP-A/D were higher than those in stable stage. The comparisons and prognosis might be different in Asian and Caucasian patients. Conclusions: Serum SP-A/D detection might be useful for differential diagnosis and prediction of survival in patients with IPF. PMID:28591049

  6. Spa treatment of Chernobyl liquidators in Israel

    International Nuclear Information System (INIS)

    Godovich, A.; Chernovskij, A.; Lyass, F.; Shapiro, I.; Kratov, Eh.; Markarov, G.

    1997-01-01

    This paper presents the first experience gained in the use of the unique climate and spa of the Dead Sea for the treatment and rehabilitation of the Chernobyl liquidators at clinic near the city of Arad. Ninety-six patients were treated in Israel, in 40 of these radiation was the etiological factor of the disease: consequences of acute and chronic radiation disease, the astheno-neurotic syndrome, discirculatory encephalopathy, subatrophic laryngopharyngitis, and obstructive bronchitis. Eighty-eight patients had direct indications for treatment at the Dad Sea; locomotory, respiratory, and skin diseases. The course of treatment included the Dad Sea baths, mud applications, sun baths, climatotherapy, physiotherapy, massage, bioenergy therapy, inhalations, moisturizing creams, etc. An appreciable improvement with resolution of the principal symptoms was attained in 82% of patients, in 13% improvement with a significant abatement of the symptoms was achieved, whereas in 5% no apparent results were seen

  7. Influence of amendments on soil arsenic fractionation and phytoavailability by Pteris vittata L.

    Science.gov (United States)

    Yan, Xiulan; Zhang, Min; Liao, Xiaoyong; Tu, Shuxin

    2012-06-01

    Increasing availability of soil arsenic is of significance for accelerating phytoremediation efficiency of As-polluted sites. The effects of seven amendments, i.e., citrate, oxalate, EDTA, sodium polyacrylate (SPA), phosphate rock (PR), single superphosphate (SSP), and compost on fractionation and phytoavailability of soil As were investigated in lab culture experiment. The results showed that the addition of PR, SPA, EDTA or compost to soils significantly increased the concentration of NaHCO(3)-extractable As over a 120 d incubation period compared with the control (amendment-free) soil. Then, the four amendments were selected to add to As-contaminated soil growing Pteris vittata. It was concluded that As accumulation by the fern increased significantly under the treatments of PR and SPA by 25% and 31%, respectively. For As fractionation in soil, SPA increased Fe-As significantly by 51% and PR increased Ca-As significantly by 18%, while both the two amendments reduced occluded-As by 16% and 19%, respectively. Adding PR and SPA in soil increased the activities of urease and neutral phosphatase resulting from the improvement the fertility and physical structure of the soil, which benefits plant growth and As absorption of P. vittata. The results of the research revealed that both PR and SPA were effective amendments for improving phytoremediation of As-contaminated sites by P. vittata. Copyright © 2012 Elsevier Ltd. All rights reserved.

  8. Combined spa-exercise therapy is effective in patients with ankylosing spondylitis: a randomized controlled trial

    NARCIS (Netherlands)

    van Tubergen, A.; Landewé, R.; van der Heijde, D.; Hidding, A.; Wolter, N.; Asscher, M.; Falkenbach, A.; Genth, E.; Thè, H. G.; van der Linden, S.

    2001-01-01

    To determine the efficacy of combined spa-exercise therapy in addition to standard treatment with drugs and weekly group physical therapy in patients with ankylosing spondylitis (AS). A total of 120 Dutch outpatients with AS were randomly allocated into 3 groups of 40 patients each. Group 1 (mean

  9. Radon exposure during treatment in some thermal spa centers in Greece

    International Nuclear Information System (INIS)

    Nikolopoulos, D.; Louizi, A.; Serefoglou, A.; Georgiou, E.; Vogiannis, E.; Halvadakis, C.

    2004-01-01

    Radon ( 222 Rn) present in the spa facilities has been identified as an agent of additional radiation burden both for bathers and the working personnel. Although some researchers have been concentrated on the health impact of radon activity transient increases due to water flow of domestically used water, limited work has been reported on this effect in spa facilities. The aim of this work was to study the exposure both of bathers and working personnel due to water flow under working conditions in some thermal spas in Greece. The spas studied were built at two locations in Greece; Lesvos Island and the city of Loutra- Edipsou. The study was performed between 1999 and 2003. Measurements involved determination of radon concentration in the waters of the thermal spas, monitoring of radon and short-lived decay product activity (both in attached and unattached form) and coarse particles (> 500 nm). Water radon concentration was measured by Alpha Guard PQ2000Pro of Genitron GmbH equipped with an appropriate unit (Aquakit). Indoor radon activity was monitored by Alpha Guard PQ2000Pro and EQF3023 of Sarad GmbH which was also used for monitoring of radon short-lived decay product activity. Coarse particle concentration measurements were performed by a GRIMM 1.104 Portable Dust Monitor. Measurements indoors were performed in the treatment room and in the reception room, if existing, under working conditions. Several procedures for bath filling and pouring out of the treatment room, during the measurements, were studied. Radon concentrations of thermal waters were found to lie in the range 1 Bq.L -1 and 304 Bq.L -1 . Some of these concentrations may be considered as elevated. Elevated (about 2-6 kBq.m -3 ) indoor radon concentrations were measured in the treatment rooms of the spas of Polichnitos, Eftalou and Loutra Edipsou. This found to be in accordance to the high radon potential of these spas, as detected out of the measurements of their thermal waters. Concentration

  10. The rSPA Processes of River Water-quality Analysis System for Critical Contaminate Detection, Classification Multiple-water-quality-parameter Values and Real-time Notification

    OpenAIRE

    Chalisa VEESOMMAI; Yasushi KIYOKI

    2016-01-01

    The water quality analysis is one of the most important aspects of designing environmental systems. It is necessary to realize detection and classification processes and systems for water quality analysis. The important direction is to lead to uncomplicated understanding for public utilization. This paper presents the river Sensing Processing Actuation processes (rSPA) for determination and classification of multiple-water- parameters in Chaophraya river. According to rSPA processes of multip...

  11. Waste heat utilization in the thermal spa of Lavey-les-Bains; Etude de la valorisation des rejets thermiques des Bains de Lavey

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This final report for the Swiss Federal Office of Energy looks at the possibilities for improved waste water utilization in the Lavey-les-Bains thermal spa, Switzerland. According to the regulations in force, the temperature of the waste water rejected into the Rhone river shall not exceed 30 {sup o}C, what is currently not the case. Also the operational cost shall be reduced and the waste water quality improved. The installations are presented. From the two geothermal wells, mineral water comes out at an average flow rate of 940 l/min and a temperature of 63 {sup o}C. Actual waste water data are reported. The measured thermal water consumption data, including seasonal variations, are analysed by computerized simulation and measures to reduce the consumed volume by the optimization of internal procedures are evaluated. Measures to reduce the quantity of the rejected free chlorine are discussed. Several possible adaptations of the existing space heating, domestic water heating and pools' heating are evaluated, including cost. In addition, extensions of the thermal spa center to recreational activities are discussed, as the construction of a tropical greenhouse is.

  12. [INDENA SPA company's patent portfolio of Ginkgo biloba preparation].

    Science.gov (United States)

    Wang, Nan; Guo, Kai; Cheng, Xin-min; Liu, Wei

    2015-10-01

    INDENA SPA Company in Italy is a multi-national company that produces and sells plant extracts. Based on its own re- search advantages in the field of Ginkgo biloba preparation, the company protects its own products market effectively through building patent portfolio around the patents of its opponent. Based on the multi-angle analysis for patent portfolio of G. biloba preparation from the aspects of application time, legal status, technical development route, and patent portfolio layout, this article provides technical reference on research and development of G. biloba preparation, and the author suggest that Chinese applicants learn techniques and layout experiences of other patents fully to enhance the level of research and patent protection level.

  13. Constructing a Professional: Gendered Knowledge in the (Self-)Positioning of Skin and Spa Therapy Students

    Science.gov (United States)

    Bredlöv, Eleonor

    2017-01-01

    This study outlines the self-positioning of skin and spa therapy students. More specifically, it focuses how they position themselves as professionals in terms of knowledge, and how gender is at play throughout this process. Drawing on a poststructural approach, inspired by Foucault and feminist theory, regularities of description and…

  14. Tourism of Krapinske Toplice Spa - present position and possibilities of Its development

    Directory of Open Access Journals (Sweden)

    Martina Jakovčić

    2003-01-01

    Full Text Available This paper presents present state of development of tourism in Krapinske Toplice Spa and possibilities of further development from the geographical point of view. Natural, socio-economical, cultural and historical components of the area are analysed. Special attention is given to development of health tourism and its impact on the development of other types of tourism. Paper explains the main reason of slower tourist development of Krapinske Toplice in comparison to other spas in the region.

  15. 76 FR 7694 - Airworthiness Directives; PIAGGIO AERO INDUSTRIES S.p.A Model PIAGGIO P-180 Airplanes

    Science.gov (United States)

    2011-02-11

    ... Airworthiness Directives; PIAGGIO AERO INDUSTRIES S.p.A Model PIAGGIO P-180 Airplanes AGENCY: Federal Aviation... Piaggio service bulletin number specified in the Alternative Methods of Compliance (AMOCs) section is..., except Federal holidays. The AD docket contains this AD, the regulatory evaluation, any comments received...

  16. Cost-effectiveness and efficacy of spa, SCCmec, and PVL genotyping of methicillin-resistant Staphylococcus aureus as compared to pulsed-field gel Electrophoresis.

    Directory of Open Access Journals (Sweden)

    Vincent Li

    Full Text Available Pulsed-field gel electrophoresis (PFGE is a valuable molecular typing assay used for methicillin-resistant Staphylococcus aureus (MRSA surveillance and genotyping. However, there are several limitations associated with PFGE. In Alberta, Canada, the significant increase in the number of MRSA isolates submitted to the Provincial Laboratory for Public Health (ProvLab for PFGE typing led to the need for an alternative genotyping method. In this study, we describe the transition from PFGE to Staphylococcus protein A (spa, Staphylococcal cassette chromosome (SCCmec, and Panton-Valentine leukocidin (PVL typing. A total of 1915 clinical MRSA isolates collected from 2005 to 2009 were used to develop and validate an algorithm for assigning PFGE epidemic types using spa, SCCmec, and PVL typing and the resulting data was used to populate a new Alberta MRSA typing database. An additional 12620 clinical MRSA isolates collected from 2010 to 2012 as part of ongoing routine molecular testing at ProvLab were characterized using the new typing algorithm and the Alberta MRSA typing database. Switching to spa, SCCmec, and PVL from PFGE typing substantially reduced hands-on and turn-around times while maintaining historical PFGE epidemic type designations. This led to an approximate $77,000 reduction in costs from 2010 to 2012. PFGE typing is still required for a small subset of MRSA isolates that have spa types that are rare, novel, or associated with more than one PFGE epidemic type.

  17. Family-based transmission disequilibrium test (TDT) and case-control association studies reveal surfactant protein A (SP-A) susceptibility alleles for respiratory distress syndrome (RDS) and possible race differences

    NARCIS (Netherlands)

    Floros, J.; Fan, R.; Matthews, A.; DiAngelo, S.; Luo, J.; Nielsen, H.; Dunn, M.; Gewolb, I. H.; Koppe, J.; Van Sonderen, L.; Farri-Kostopoulos, L.; Tzaki, M.; Rämet, M.; Merrill, J.

    2001-01-01

    A key cause of respiratory distress syndrome (RDS) in the prematurely born infant is deficiency of pulmonary surfactant, a lipoprotein complex. Both low levels of surfactant protein A (SP-A) and SP-A alleles have been associated with RDS. Using the candidate gene approach, we performed family-based

  18. LHC suppliers win Golden Hadron awards : Sandro Ferraris and Guiseppi Ginola from Simic SpA

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    Simic SpA (Italy) received its award for manufacturing the vacuum vessels for the superconducting dipoles. The 937 blue cylinders manufactured by Simic will provide the thermal insulation for the magnets. Measuring 15 metres in length and 1 metre in diameter, they are designed to withstand a vacuum of 10-4 Pa.

  19. [The psychological security in the framework of the system of factors responsible for the effectiveness of spa and health resort-based rehabilitation].

    Science.gov (United States)

    Krasnyanskaya, T M; Tylets, V G

    The present work was designed to address the problem of ensuring the psychological security in the framework of organization of the rehabilitative treatment based at the spa and health resort facilities. We undertook the questionnaire study for which 650 subjects were recruited among those attending spa and health resort facilities of the cities of Essentuki and Kislovodsk. The participants were asked to estimate the level of their personal security and the quality of the provided means for the rehabilitative treatment and general health improvement. It was found that as many as 43% of the respondents reported the moderate level of psychological security whereas about 30% of them estimated the level of their psychological security as low. Overall, the attitude toward the available means for health improvement and rehabilitation proved extremely variable. The factorial analysis has demonstrated the highly subjective opinions of the responders as regards the provided services categorized in terms of therapeutic (mineral water, preformed physical factors, peloid and dietary therapy), health improvement (herbal medicine, therapeutic physical training, therapy, bioclimatic therapy), and recreational (animation, excursion and touristic activities) factors. The value of these factors was perceived differently by the vacationers with different feelings of psychological security. Those reporting the high level of psychological security demonstrated the positive attitude toward all factors and circumstances available for the general improvement of the health status whereas the holidaymakers reporting the moderate level of personal psychological security exhibited the non-equivalent attitude toward the provided services; namely, they highly estimated the available therapeutic factors but either underestimated the value of the constituent components of the health improving and recreational factors or demonstrated the very selective attitude toward their assessment. Generally

  20. Triangular relationship between sleep spindle activity, general cognitive ability and the efficiency of declarative learning.

    Directory of Open Access Journals (Sweden)

    Caroline Lustenberger

    Full Text Available EEG sleep spindle activity (SpA during non-rapid eye movement (NREM sleep has been reported to be associated with measures of intelligence and overnight performance improvements. The reticular nucleus of the thalamus is generating sleep spindles in interaction with thalamocortical connections. The same system enables efficient encoding and processing during wakefulness. Thus, we examined if the triangular relationship between SpA, measures of intelligence and declarative learning reflect the efficiency of the thalamocortical system. As expected, SpA was associated with general cognitive ability, e.g. information processing speed. SpA was also associated with learning efficiency, however, not with overnight performance improvement in a declarative memory task. SpA might therefore reflect the efficiency of the thalamocortical network and can be seen as a marker for learning during encoding in wakefulness, i.e. learning efficiency.

  1. Spa as Arena of Career Woman Resistance to Patriarch Domination

    Directory of Open Access Journals (Sweden)

    Bhernadetta Pravita Wahyuningtyas

    2011-04-01

    Full Text Available This study examines the career women who use the habit of treating the body through the routine of coming to spas, which aims to overcome the dominance of patriarchy. This study uses several concepts. First, muted group theory, which states that woman, is the one that silenced; so to overcome this condition, women should perform self-transformation. The transformation is aligned with the second concept, feminist existentialist, which defines the transformation as the change of a woman concept from Other to Self. The transformation can be achieved not only by working outside the domestic sphere, but also supported by a good appearance through a complete body treatment. Grooming habits acquired through socialization that derived in woman since their childhood. The socialization is about how women as a person who is considered weak by the world of patriarchal domination using the power of their beauty to master, subdue, and break the domination in her life. Then, with their good appearance, woman can express their existence in everything that they do from object become subject. Spa and the whole result of the activities contained in it then consciously become a way of resistance that being used by the career woman against the domination of patriarchy which overshadowing their lives. 

  2. 75 FR 22512 - Airworthiness Directives; Piaggio Aero Industries S.p.A. Model PIAGGIO P-180 Airplanes

    Science.gov (United States)

    2010-04-29

    ... Airworthiness Directives; Piaggio Aero Industries S.p.A. Model PIAGGIO P-180 Airplanes AGENCY: Federal Aviation... presence of potential ignition sources such as electrical equipment and connectors. As a consequence, this..., agree with their substance. But we might have found it necessary to use different words from those in...

  3. 75 FR 67639 - Airworthiness Directives; Piaggio Aero Industries S.p.A Model PIAGGIO P-180 Airplanes

    Science.gov (United States)

    2010-11-03

    ... Friday, except Federal holidays. For service information identified in this proposed AD, contact Piaggio... Piaggio Aero Industries have issued service information (referred to after this as ``the MCAI''), to... Information Piaggio Aero Industries S.p.A. has issued Service Bulletin (Mandatory) N.: SB 80-0275, Rev. N. 0...

  4. 76 FR 62605 - Virginia Graeme Baker Pool and Spa Safety Act; Interpretation of Unblockable Drain

    Science.gov (United States)

    2011-10-11

    ... the VGB Act defines an ``unblockable drain'' as ``a drain of any size and shape that a human body... intentions. They claim that for this reason, backup systems are necessary, and a swimming pool or spa with a... of an ``unblockable drain,'' at 16 CFR 1450.2(b) and believe it was in error. Regardless of the size...

  5. Comparison of structured and unstructured physical activity training on predicted VO2max and heart rate variability in adolescents - a randomized control trial.

    Science.gov (United States)

    Sharma, Vivek Kumar; Subramanian, Senthil Kumar; Radhakrishnan, Krishnakumar; Rajendran, Rajathi; Ravindran, Balasubramanian Sulur; Arunachalam, Vinayathan

    2017-05-01

    Physical inactivity contributes to many health issues. The WHO-recommended physical activity for adolescents encompasses aerobic, resistance, and bone strengthening exercises aimed at achieving health-related physical fitness. Heart rate variability (HRV) and maximal aerobic capacity (VO2max) are considered as noninvasive measures of cardiovascular health. The objective of this study is to compare the effect of structured and unstructured physical training on maximal aerobic capacity and HRV among adolescents. We designed a single blinded, parallel, randomized active-controlled trial (Registration No. CTRI/2013/08/003897) to compare the physiological effects of 6 months of globally recommended structured physical activity (SPA), with that of unstructured physical activity (USPA) in healthy school-going adolescents. We recruited 439 healthy student volunteers (boys: 250, girls: 189) in the age group of 12-17 years. Randomization across the groups was done using age and gender stratified randomization method, and the participants were divided into two groups: SPA (n=219, boys: 117, girls: 102) and USPA (n=220, boys: 119, girls: 101). Depending on their training status and gender the participants in both SPA and USPA groups were further subdivided into the following four sub-groups: SPA athlete boys (n=22) and girls (n=17), SPA nonathlete boys (n=95) and girls (n=85), USPA athlete boys (n=23) and girls (n=17), and USPA nonathlete boys (n=96) and girls (n=84). We recorded HRV, body fat%, and VO2 max using Rockport Walk Fitness test before and after the intervention. Maximum aerobic capacity and heart rate variability increased significantly while heart rate, systolic blood pressure, diastolic blood pressure, and body fat percentage decreased significantly after both SPA and USPA intervention. However, the improvement was more in SPA as compared to USPA. SPA is more beneficial for improving cardiorespiratory fitness, HRV, and reducing body fat percentage in terms of

  6. Effect of calorie restriction on spontaneous physical activity and body mass in mice divergently selected for basal metabolic rate (BMR).

    Science.gov (United States)

    Brzęk, Paweł; Gębczyński, Andrzej K; Książek, Aneta; Konarzewski, Marek

    2016-07-01

    Spontaneous physical activity (SPA) represents an important component of daily energy expenditures in animals and humans. Intra-specific variation in SPA may be related to the susceptibility to metabolic disease or obesity. In particular, reduced SPA under conditions of limited food availability may conserve energy and prevent loss of body and fat mass ('thrifty genotype hypothesis'). However, both SPA and its changes during food restriction show wide inter-individual variations. We studied the effect of 30% caloric restriction (CR) on SPA in laboratory mice divergently selected for high (H-BMR) and low (L-BMR) basal metabolic rate. Selection increased SPA in the H-BMR line but did not change it in the L-BMR mice. This effect reflected changes in SPA intensity but not SPA duration. CR increased SPA intensity more strongly in the L-BMR line than in the H-BMR line and significantly modified the temporal variation of SPA. However, the initial between-line differences in SPA were not affected by CR. Loss of body mass during CR did not differ between both lines. Our results show that the H-BMR mice can maintain their genetically determined high SPA under conditions of reduced food intake without sacrificing their body mass. We hypothesize that this pattern may reflect the higher flexibility in the energy budget in the H-BMR line, as we showed previously that mice from this line reduced their BMR during CR. These energy savings may allow for the maintenance of elevated SPA in spite of reduced food intake. We conclude that the effect of CR on SPA is in large part determined by the initial level of BMR, whose variation may account for the lack of universal pattern of behavioural responses to CR. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Evaluation of serum prolidase activity and oxidative stress markers in men with BPH and prostate cancer.

    Science.gov (United States)

    Kucukdurmaz, Faruk; Efe, Erkan; Çelik, Ahmet; Dagli, Hasan; Kılınc, Metin; Resim, Sefa

    2017-12-12

    Prostate cancer (PCa) and benign prostatic hyperplasia (BPH) are diseases of elderly men and are related to increased oxidative stress (OS). Although prolidase has a role in collagen metabolism, it is also used to evaluate OS in many diseases. However, there is a lack of data about serum prolidase activity (SPA) in prostate cancer. The aim of this study was to evaluate and compare SPA levels in males with BPH and PCa. Evaluation was made of a total of 81 men who underwent transrectal ultrasound guided prostate biopsy for a definitive diagnosis due to high PSA levels. Patients were separated into 2 groups as BPH and PCa patients. Pre-biopsy malondialdehyde (MDA), superoxide dismutase (SOD), PSA levels and serum prolidase activities (SPA) were compared between the groups and the correlations of SPA with the other parameters were also investigated in both groups. BPH was diagnosed in 51 patients and PCa in 30. The mean age of patients was similar in both groups as 63.25 ± 5.81 years in the BPH group 65.30 ± 7.35 years in the PCa group(p:0.081). The median MDA and SOD levels were insignificantly increased in the PCa patients. SPA values were similar in BPH and PCa patients. SPA did not correlate with age, PSA, MDA or SOD levels in either group. Our study results revealed that serum prolidase activity is similar in BPH and PCa cases and is not correlated with MDA, SOD or PSA levels.

  8. Evaluasi Hasil Implementasi the Coordinated Mekong Ministerial Initiative Against Trafficking Sub-regional Plan of Action (Commit Spa) Dalam Menangani Human Trafficking Di Thailand Periode 2011-2013

    OpenAIRE

    Rahmahwati, Isti Nur; Windiani, Reni; Putranti, Ika Riswanti

    2015-01-01

    Thailand, Laos, Myanmar, China, Vietnam, and Cambodia createdCOMMIT and COMMIT SPA. During COMMIT SPAimplementation period 2011-2013, the number of human traffickingincreased in Thailand. Most of human trafficking victims in Thailandare exploited into sexual exploitation and forced labor. The studyaims to analyze causes of human trafficking increased duringCOMMIT SPA implementation. The study result is the increase ofhuman trafficking is caused by Thailand's interests by using sextrafficking ...

  9. LHC suppliers win Golden Hadron awards : Gianfranco Malvestiti and Ernesto Malvestiti de Ernesto Malvestiti SpA (Italie)

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    Ernesto Malvestiti SpA (Italy) is the main manufacturer of the metal collars needed to ensure the rigidity of the superconducting dipoles. The firm was awarded its prize in recognition of the central role it played during the transition from aluminium to stainless-steel collars.

  10. Data showing non-conventional HLA-B27 expression in axial joints and gut tissue from B27 transgenic rats, and in frozen and paraffin-fixed synovial SpA tissue

    NARCIS (Netherlands)

    Rysnik, Oliwia; McHugh, Kirsty; van Duivenvoorde, Leonie; van Tok, Melissa; Taurog, Joel; Kollnberger, Simon; Baeten, Dominique; Bowness, Paul

    2016-01-01

    Data is presented showing expression of non-conventional (NC) heavy chain forms of B27 in synovial tissues from SpA patients. Data is presented showing the expression patterns of NC-B27 in joint, gastrointestinal and lymphoid tissues from B27 transgenic (TG(1)) rats with M. tuberculosis-induced SpA.

  11. Lessons from the SPA European performance assessment exercise for spent fuel disposal in granite

    International Nuclear Information System (INIS)

    Baudoin, P.; Besnus, F.; Gay, D.; Serres, C.

    2000-01-01

    The SPA project, addressing performance assessment of spent fuel disposal, is a direct continuation of the efforts made by the European Community since 1982 to build a common understanding of the methods applicable to performance assessment of a deep geological disposal. It enabled to draw preliminary conclusions on the respective importance of the radionuclides present in the different types of waste, on the influence of some of the main assumptions used in the modelling and helped to specify the expectable role of disposal system components. From 1996 to 1999, six national research institutions in six member countries of EU (Spain, Germany, France, The Netherlands, Belgium and Finland) were involved in this project devoted to the case of spent fuel. This paper only addresses the assessments made by IPSN (France) for the granite site in the case of the normal evolution scenario. According to the results obtained, the maximum effective dose is in a first time mainly caused by two fission products ( 129 I and 79 Se). Then, radionuclides from radioactive decay chains ( 226 Ra , 230 Th and 229 Th) progressively become the main contributors. (author)

  12. Characterization of Si(112) and In/Si(112) studied by SPA-LEED

    Energy Technology Data Exchange (ETDEWEB)

    Hoecker, Jan; Speckmann, Moritz; Schmidt, Thomas; Falta, Jens [Institute of Solid State Physics, University of Bremen, 28359 Bremen (Germany)

    2010-07-01

    High index surfaces are of strong interest in todays research because of the possibility to grow low dimensional structures. It has for instance already been shown that the adsorption of Ga can induce the formation of 1D metal chains on Si(112) (cf. Snijders et al., PRB 72, 2005). In this work we investigated the clean Si(112) surface and the adsorption of In on Si(112) to establish an analogy to Ga/Si(112) using spot profile analyzing low energy electron diffraction (SPA-LEED). By means of reciprocal space mapping we determined the bare Si(112) surface to be decomposed into alternating (5512) and (111) facets in [1 anti 10] direction with (2 x 1) and (7 x 7) reconstruction, respectively (cf. Baski et al., Surf. Sci. 392, 1997). With SPA-LEED we were able to observe the decreasing intensity of the facet spots in-situ while depositing In on Si(112) and thus reveal the smoothening of the surface due to the deposition of In. At saturation coverage we found a (3.x1) reconstruction, where x is dependent on the deposition temperature and changes from x=7 at 400 C to x=5 at 500 C. This leads us to the assumption that the reconstruction is not incommensurate but a mixture of (3 x 1) and (4 x 1) building blocks, which is very similar to the super structure of Ga on Si(112).

  13. A online credit evaluation method based on AHP and SPA

    Science.gov (United States)

    Xu, Yingtao; Zhang, Ying

    2009-07-01

    Online credit evaluation is the foundation for the establishment of trust and for the management of risk between buyers and sellers in e-commerce. In this paper, a new credit evaluation method based on the analytic hierarchy process (AHP) and the set pair analysis (SPA) is presented to determine the credibility of the electronic commerce participants. It solves some of the drawbacks found in classical credit evaluation methods and broadens the scope of current approaches. Both qualitative and quantitative indicators are considered in the proposed method, then a overall credit score is achieved from the optimal perspective. In the end, a case analysis of China Garment Network is provided for illustrative purposes.

  14. SP-A-enriched surfactant for treatment of rat lung transplants with SP-A deficiency after storage and reperfusion

    NARCIS (Netherlands)

    Erasmus, ME; Hofstede, GJH; Petersen, AH; Batenburg, JJ; Haagsman, HP; Oetomo, SB; Prop, J

    2002-01-01

    Background. The function of pulmonary surfactant is affected by lung transplantation, contributing to impaired lung transplant function. A decreased amount of surfactant protein-A (SP-A) after reperfusion is believed to contribute to the impaired surfactant function. Surfactant treatment has been

  15. "Roman Baths" in Contemporary Spa Tourism

    Directory of Open Access Journals (Sweden)

    Vesna Merc

    2005-07-01

    Full Text Available The commercialisation of images and symbols from antiquity, so characteristic of Slovenia since its independence, has been reflected over the last decade in spa tourism as well. Since the great crises in the sixties, and especially since the eighties, fifteen Slovene natural health resorts have concentrated on developing wellness and activities programs. This change in orientation has been accompanied by renovations, an expansion of the water surfaces and capacities, and new wellbeing, wellness, spirituality and beauty programs. An analysis of Slovene spas, wellness centres and hotel web pages shows that they frequently offer rooms, usually saunas, which are imitations of the Roman baths. These rooms are usually called "Roman saunas", "Tepidarium", "Caldarium", and "Roman-Irish baths". At Terme Ptuj, Zdravilišče Laško, Šmarješke Toplice, Grand Hotel Palace in Portorož, and Terme Čatež, saunas have been built or renovated in the Roman style. This trend of Roman rooms is a novelty, less than a decade old in Slovenia. The first sauna with a Roman theme, a Roman-Irish bath, was opened in 1997 in the Health and Beauty Centre at Terme Čatež. Modern Roman saunas are very popular, found not only in Slovenia but also in other parts of Europe, especially Germany and Austria. Their popularity has spread from the areas formerly occupied by the Romans to other parts of world, for example the USA and the Republic of South Africa. An analysis of Slovene saunas and wellness centres reveals a well-established trend to recreate certain parts of the Roman baths. This is attempted not only through Roman-style decorations, but also through certain structures particular to the Roman baths, such as the caldarium, tepidarium, and in one case even a laconicum. The approach, however, is highly eclectic, blending Roman, Greek and, above all, modern elements. The purpose of such rooms is to increase the appeal of the spas, while their design is mostly based on

  16. 76 FR 4056 - Airworthiness Directives; PIAGGIO AERO INDUSTRIES S.p.A Model PIAGGIO P-180 Airplanes

    Science.gov (United States)

    2011-01-24

    ..., is considered the State of Design for PIAGGIO AERO INDUSTRIES S.p.A Model PIAGGIO P- 180 airplanes. A... ensuring that the drain lines of the environmental unit condenser are not clogged. Since AD 2007-24-15... condition described previously is likely to exist or develop in other products of the same type design. AD...

  17. The system of processing and analysis of the parameters to be controlled of the 'Ukrytie' (SPA)

    International Nuclear Information System (INIS)

    Shcherbin, V.N.; Kravchuk, T.A.; Nenakhov, A.N.

    1998-01-01

    Processing system and analysis of parameters to be controlled (SPA) is an integrated system monitor control, which unites complexes of technical facilities with methods of remote control and diagnostics of object 'Ukrytie'. System executes checking, diagnosing analytical, prognostic, scholastic-simulator and scientifically-methodical functions, describing current condition of the 'Ukrytie', with the issue of possible emergency situation descriptions

  18. Light and the E3 ubiquitin ligase COP1/SPA control the protein stability of the MYB transcription factors PAP1 and PAP2 involved in anthocyanin accumulation in Arabidopsis.

    Science.gov (United States)

    Maier, Alexander; Schrader, Andrea; Kokkelink, Leonie; Falke, Christian; Welter, Bastian; Iniesto, Elisa; Rubio, Vicente; Uhrig, Joachim F; Hülskamp, Martin; Hoecker, Ute

    2013-05-01

    Anthocyanins are natural pigments that accumulate only in light-grown and not in dark-grown Arabidopsis plants. Repression of anthocyanin accumulation in darkness requires the CONSTITUTIVELY PHOTOMORPHOGENIC1/SUPPRESSOR OF PHYA-105 (COP1/SPA) ubiquitin ligase, as cop1 and spa mutants produce anthocyanins also in the dark. Here, we show that COP1 and SPA proteins interact with the myeloblastosis (MYB) transcription factors PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP)1 and PAP2, two members of a small protein family that is required for anthocyanin accumulation and for the expression of structural genes in the anthocyanin biosynthesis pathway. The increased anthocyanin levels in cop1 mutants requires the PAP1 gene family, indicating that COP1 functions upstream of the PAP1 gene family. PAP1 and PAP2 proteins are degraded in the dark and this degradation is dependent on the proteasome and on COP1. Hence, the light requirement for anthocyanin biosynthesis results, at least in part, from the light-mediated stabilization of PAP1 and PAP2. Consistent with this conclusion, moderate overexpression of PAP1 leads to an increase in anthocyanin levels only in the light and not in darkness. Here we show that SPA genes are also required for reducing PAP1 and PAP2 transcript levels in dark-grown seedlings. Taken together, these results indicate that the COP1/SPA complex affects PAP1 and PAP2 both transcriptionally and post-translationally. Thus, our findings have identified mechanisms via which the COP1/SPA complex controls anthocyanin levels in Arabidopsis that may be useful for applications in biotechnology directed towards increasing anthocyanin content in plants. © 2013 The Authors The Plant Journal © 2013 John Wiley & Sons Ltd.

  19. Single Piezo-Actuator Rotary-Hammering (SPaRH) Drill

    Science.gov (United States)

    Sherrit, Stewart (Inventor); Bao, Xiaoqi (Inventor); Badescu, Mircea (Inventor); Bar-Cohen, Yoseph (Inventor)

    2014-01-01

    A Single Piezo-Actuator Rotary-Hammering (SPaRH) Drill includes a horn actuator having high power piezoelectric materials and a flexure pre-stress to increase the actuators effectiveness. The drill is a low mass, low power, compact coring drill measuring 20-cm high by 7-cm diameter and having a total weight of 2 kg including drive electronics. Using an average power of 50-Watts, the drill basalt is expected to cut basalt at a rate of 0.2 cm/min down to depth of 10-cm and create cuttings and an intact core. The drill is expected to operate under different environments including Martian ambient (6 Torr and down to -50 degree C), and liquid nitrogen temperatures (77 K) and low pressure (<<1 Torr) to simulate lunar polar and Europa conditions. Materials expected to be sampled include Kaolinite, Saddleback Basalt, Limestone, Volcanic Breccia, Siltstone, ice, permafrost and layered rocks with different hardness.

  20. spa Typing and Multilocus Sequence Typing Show Comparable Performance in a Macroepidemiologic Study of Staphylococcus aureus in the United States.

    Science.gov (United States)

    O'Hara, F Patrick; Suaya, Jose A; Ray, G Thomas; Baxter, Roger; Brown, Megan L; Mera, Robertino M; Close, Nicole M; Thomas, Elizabeth; Amrine-Madsen, Heather

    2016-01-01

    A number of molecular typing methods have been developed for characterization of Staphylococcus aureus isolates. The utility of these systems depends on the nature of the investigation for which they are used. We compared two commonly used methods of molecular typing, multilocus sequence typing (MLST) (and its clustering algorithm, Based Upon Related Sequence Type [BURST]) with the staphylococcal protein A (spa) typing (and its clustering algorithm, Based Upon Repeat Pattern [BURP]), to assess the utility of these methods for macroepidemiology and evolutionary studies of S. aureus in the United States. We typed a total of 366 clinical isolates of S. aureus by these methods and evaluated indices of diversity and concordance values. Our results show that, when combined with the BURP clustering algorithm to delineate clonal lineages, spa typing produces results that are highly comparable with those produced by MLST/BURST. Therefore, spa typing is appropriate for use in macroepidemiology and evolutionary studies and, given its lower implementation cost, this method appears to be more efficient. The findings are robust and are consistent across different settings, patient ages, and specimen sources. Our results also support a model in which the methicillin-resistant S. aureus (MRSA) population in the United States comprises two major lineages (USA300 and USA100), which each consist of closely related variants.

  1. 75 FR 65263 - Virginia Graeme Baker Pool and Spa Safety Act; Public Accommodation; Withdrawal of Proposed Rule

    Science.gov (United States)

    2010-10-22

    ...'' or ``Act'') as ``an inn, hotel, motel, or other place of lodging, except for an establishment located... interpretive rule to interpret ``public accommodations facility'' in the VGB Act as ``an inn, hotel, motel, or... CONSUMER PRODUCT SAFETY COMMISSION 16 CFR Part 1450 Virginia Graeme Baker Pool and Spa Safety Act...

  2. Brote de legionelosis asociado a un balneario Legionella outbreak at a spa

    Directory of Open Access Journals (Sweden)

    E. Serrano Ibarbia

    2001-06-01

    Full Text Available En 1998 el inicio de la temporada de actividad de un balneario en Gipuzkoa coincidió con la detección de un brote de legionelosis asociado al mismo, lo cual condujo al cierre de la instalación y al estudio epidemiológico -casos y controles- y ambiental oportunos. Se definió como caso toda persona que durante su estancia en el balneario o durante los 10 días siguientes presentará neumonía o un cuadro febril compatible con fiebre de Pontiac.El estudio ambiental incluyó la inspección del balneario y entorno y muestreos de los sistemas sanitarios de agua y de los elementos de hidroterapia.De las 287 personas encuestadas de la Comunidad Autónoma Vasca, el 12.5% cumplían con la definición de caso; 9 casos presentaron neumonía y 26 fiebre de Pontiac. La curva epidémica se inició el 7 de mayo, alcanzando un pico los días 14 y 15 de mayo y finalizando el día 20. El riesgo de enfermar ajustado por edad, sexo y consumo de tabaco se asoció con la duración de la estancia en el balneario (OR=118.5, 95% I.C: 18.7-750.2 y con el uso de una piscina (OR=10.5, 95% I.C: 1.3-82.6. Se detecto L. pneumophila serogrupo1 en recuentos superiores a 103 ufc/l en diversos puntos de la red de hidroterapia y en la ducha de la habitación de uno de los enfermos. El análisis por electroforesis en campos pulsados de una muestra biológica y muestras ambientales permitió la confirmación genotípica. El establecimiento se abrió al público tras realizar un tratamiento de choque y comprobar que transcurridos 15 días no se detectó L. pneumophila en las muestras ambientales.The start of seasonal activity at a spa in Guipuzcoa coincided with the detection of an associated legionnaire outbreak in 1998. This led to the closure of the premises and to the carrying out of opportune environmental and epidemiological studies. The latter included case-control study. A case was defined as a person who, either during his stay or in a period of 10 days thereafter

  3. COMPETITIVENESS THROUGH SUSTAINABILITY AND FINANCIAL EFFICIENCY OF SPA TOURIST DESTINATIONS

    Directory of Open Access Journals (Sweden)

    Anis Cecilia

    2010-12-01

    Full Text Available In the specific literature, success may be achieved by two important attributes: competitiveness and sustainability. Competitive advantage represents an essential criterion for surviving on the tourist market and defines the ability of one destination to use these resources effectively and in the long term. The paper work continue a study begun last year by the same authors about tourist perception of attractiveness of the two tourist SPA destinations (Buziaş and Băile Felix on a different market segment (18-35 years old people. This time, we undertake an analysis on SC Turism Felix SA in order to determine and underline the tourist competitiveness through sustainability and financial efficiency (tourism performance indicators evolution, market share, turnover, investment volume, financial returns and costs.

  4. Eco-SpaCE: An object-oriented, spatially explicit model to assess the risk of multiple environmental stressors on terrestrial vertebrate populations

    International Nuclear Information System (INIS)

    Loos, Mark; Ragas, Ad M.J.; Plasmeijer, Rinus; Schipper, Aafke M.; Hendriks, A. Jan

    2010-01-01

    Wildlife organisms are exposed to a combination of chemical, biological and physical stressors. Information about the relative impact of each stressor can support management decisions, e.g., by the allocation of resources to counteract those stressors that cause most harm. The present paper introduces Eco-SpaCE; a novel receptor-oriented cumulative exposure model for wildlife species that includes relevant ecological processes such as spatial habitat variation, food web relations, predation, and life history. A case study is presented in which the predicted mortality due to cadmium contamination is compared with the predicted mortality due to flooding, starvation, and predation for three small mammal species (Wood mouse, Common vole, and European mole) and a predator (Little owl) living in a lowland floodplain along the river Rhine in The Netherlands. Results indicated that cadmium is the principal stressor for European mole and Little owl populations. Wood mouse and Common vole population densities were mainly influenced by flooding and food availability. Their estimated population sizes were consistent with numbers reported in literature. Predictions for cadmium accumulation and flooding stress were in agreement with field data. The large uncertainty around cadmium toxicity for wildlife leads to the conclusion that more species-specific ecotoxicological data is required for more realistic risk assessments. The predictions for starvation were subject to the limited quantitative information on biomass obtainable as food for vertebrates. It is concluded that the modelling approach employed in Eco-SpaCE, combining ecology with ecotoxicology, provides a viable option to explore the relative contribution of contamination to the overall stress in an ecosystem. This can help environmental managers to prioritize management options, and to reduce local risks.

  5. High frequency of multidrug-resistant Staphylococcus aureus with SCCmec type III and Spa types t037 and t631 isolated from burn patients in southwest of Iran.

    Science.gov (United States)

    Parhizgari, Najmeh; Khoramrooz, Seyed Sajjad; Malek Hosseini, Seyed Ali Asghar; Marashifard, Masoud; Yazdanpanah, Mahboobeh; Emaneini, Mohammad; Gharibpour, Farzaneh; Mirzaii, Mehdi; Darban-Sarokhalil, Davood; Moein, Masoud; Naraki, Mahmood

    2016-03-01

    Methicilin resistance Staphylococcus aureus (MRSA) infections are the major challenges in hospitals, especially in the burn units. The use of molecular typing methods is essential for tracking the spread of S. aureus infection and epidemiological investigations. The aim of this study was to find the profile of the spa types and also the prevalence of each SCCmec type of S. aureus strains in a central burn hospital in southwest of Iran. A total of 81 non-duplicate S. aureus were isolated from burn patients between April 2011 and February 2012. The susceptibility of the isolates against 13 different antibiotics was tested by disk agar diffusion (DAD) method. MRSA strains were identified by amplification of mecA gene. Multiplex-polymerase chain reaction (PCR) technique was used to determine the SCCmec types of MRSA strains and all the S. aureus isolates were typed by spa typing method. Detection of mecA gene showed that 70 (86.4%) of the isolates were MRSA. The highest rate of resistance was observed for penicillin (97.5%) and erythromycin (77.8%). None of the isolates were resistant to vancomycin. Sixty-seven of the 70 MRSA isolates harbored only SCCmec type III and three untypeable isolates. Five different spa types were detected. The most common spa types were t037 (42.5%) and t631 (34.5%) and were only found in MRSA isolates. Only SCCmec type III was found in burn patients which emphasizes the HA-MRSA origin of these strains. Only five different spa types identified in this study are in accordance with one SCCmec type which indicates that a limited number of bacterial colons are circulated in the burn unit in this hospital. © 2015 APMIS. Published by John Wiley & Sons Ltd.

  6. Adjusting tourist destination marketing strategy according to the changes in the environment: Case study Bukovicka sSpa

    Directory of Open Access Journals (Sweden)

    Riznić Dejan T.

    2014-01-01

    Full Text Available Tourist destinations are compelled to create new business opportunities constantly in order to respond to the challenges that arise under the influence of a number of changes in the environment. Few of them are supporting the requirements for analyzing and creating a sustainable business and marketing strategies. The paper starts with the analysis of relevant theory and practice in decisionmaking and choosing the marketing strategy of the tourist destination, pointing to the importance of continuous adjustment of marketing strategy in order to improve the business performance and competitive advantage. A new approach to the design and management of market relations, as well as the need for adjusting marketing strategies to the changes in the environment, is presented in the case of Bukovacka Spa. In deciding, great emphasis is placed on the role and importance of innovation in marketing approaches as well as on the need to develop socially responsible marketing in order to improve its business performance and response to changes in the environment and more successfully positioning.

  7. Developmental programming of energy balance regulation: is physical activity more 'programmable' than food intake?

    Science.gov (United States)

    Zhu, Shaoyu; Eclarinal, Jesse; Baker, Maria S; Li, Ge; Waterland, Robert A

    2016-02-01

    Extensive human and animal model data show that environmental influences during critical periods of prenatal and early postnatal development can cause persistent alterations in energy balance regulation. Although a potentially important factor in the worldwide obesity epidemic, the fundamental mechanisms underlying such developmental programming of energy balance are poorly understood, limiting our ability to intervene. Most studies of developmental programming of energy balance have focused on persistent alterations in the regulation of energy intake; energy expenditure has been relatively underemphasised. In particular, very few studies have evaluated developmental programming of physical activity. The aim of this review is to summarise recent evidence that early environment may have a profound impact on establishment of individual propensity for physical activity. Recently, we characterised two different mouse models of developmental programming of obesity; one models fetal growth restriction followed by catch-up growth, and the other models early postnatal overnutrition. In both studies, we observed alterations in body-weight regulation that persisted to adulthood, but no group differences in food intake. Rather, in both cases, programming of energy balance appeared to be due to persistent alterations in energy expenditure and spontaneous physical activity (SPA). These effects were stronger in female offspring. We are currently exploring the hypothesis that developmental programming of SPA occurs via induced sex-specific alterations in epigenetic regulation in the hypothalamus and other regions of the central nervous system. We will summarise the current progress towards testing this hypothesis. Early environmental influences on establishment of physical activity are likely an important factor in developmental programming of energy balance. Understanding the fundamental underlying mechanisms in appropriate animal models will help determine whether early life

  8. Molecular characteristics of methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from patients with bacteremia based on MLST, SCCmec, spa, and agr locus types analysis.

    Science.gov (United States)

    Goudarzi, Mehdi; Seyedjavadi, Sima Sadat; Nasiri, Mohammad Javad; Goudarzi, Hossein; Sajadi Nia, Raheleh; Dabiri, Hossein

    2017-03-01

    The widespread emergence of methicillin resistant Staphylococcus aureus, as a common cause of nosocomial infections, is becoming a serious concern in global public health. The objective of the present study was to investigate antimicrobial susceptibility pattern, frequency of virulence genes and molecular characteristics of methicillin-resistant Staphylococcus aureus strains isolated from patients with bacteremia. A total of 128 methicillin-resistant Staphylococcus aureus isolates were collected during February 2015 to January 2016. In vitro antimicrobial susceptibility of the isolates was assessed using the disk diffusion method. Conventional PCR was performed for the detection of adhesion (can, bbp, ebp, fnbB, fnbA, clfB, clfA) and toxin (etb, eta, pvl, tst) encoding genes, determining the agr type, SCCmec, MLST and spa typing of the isolates. All the methicillin-resistant Staphylococcus aureus isolates were found to be sensitive to linezolid, teicoplanin, and vancomycin. Resistance to the tested antibiotics varied from 97.7% for penicillin to 24.2% for mupirocin. The rate of multi drug resistance (MDR) in the present study was 97.7%. The most commonly detected toxin and adhesion genes were tst (58.6%), and clfB (100%), respectively. The majority of SCCmec III isolates were found in agr group I while SCCmec IV and II isolates were distributed among agr group III. Multilocus Sequence Typing (MLST) of the MRSA isolates showed five different sequence types: ST239 (43%), ST22 (39.8%), ST585 (10.9%), ST45 (3.9%) and ST240 (2.3%). All of the pvl positive strains belonged to ST22-SCCmec IV/t790 clone and were MDR. Among different 7 spa types, the most common were t790 (27.3%), t037 (21.9%), and t030 (14.1%). spa types t016, t924 and spa type t383 were reported for the first time from Asia and Iran, respectively. It was shown that spa types circulating in the studied hospitals varied which support the need to perform future surveillance studies in order to understand

  9. Noise level arrangement in determined zones of homogenous development of green areas on the example of the spa park in Inowrocław

    Science.gov (United States)

    Sztubecka, Małgorzata; Skiba, Marta

    2016-11-01

    Noise measurements are usually carried out in developed areas as well as in the surroundings of traffic routes providing basis for actions in order to limit its influence on the neighboring areas. Noise measurements in park areas are rare due to belief that these areas are silent zones. Such attitude cannot be justified. This article aims to the assessment of noise appearing in determined subzones of the spa park in Inowrocław. From the research carried out it can be noticed that traffic noise does not have any important meaning for the acoustic climate of the park. It is the people who stay there who generate more noise. Comparative analysis proves the appearance and penetration of noise from the zones with greater level of noise to the ones with lower amount.

  10. Spa typing and identification of pvl genes of meticillin-resistant Staphylococcus aureus isolated from a Libyan hospital in Tripoli.

    Science.gov (United States)

    Ahmed, Mohamed O; Baptiste, Keith E; Daw, Mohamed A; Elramalli, Asma K; Abouzeed, Yousef M; Petersen, Andreas

    2017-09-01

    The purpose of the study was to investigate the molecular characteristics of meticillin-resistant Staphylococcus aureus (MRSA) isolated from clinical sources in Tripoli, Libya. A total of 95 MRSA strains collected at the Tripoli medical Centre were investigated by spa typing and identification of the Panton-Valentine Leukocidin (pvl) genes. A total of 26 spa types were characterized and distributed among nine clonal complexes; CC5 (n=32), CC80 (n=18), CC8 (n=17) and CC22 (n=12) were the most prevalent clonal complexes. In total, 34% of the isolates were positive for PVL. This study demonstrated the presence of CA-MRSA and pvl positive strains in hospital settings and underlines the importance of using molecular typing to investigate the epidemiology of MRSA. Preventative measures and surveillance systems are needed to control and minimize the spread of MRSA in the Libyan health care system. Copyright © 2017 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.

  11. Genomic and Functional Characterization of the Unusual pLOCK 0919 Plasmid Harboring the spaCBA Pili Cluster in Lactobacillus casei LOCK 0919

    Czech Academy of Sciences Publication Activity Database

    Aleksandrzak-Piekarczyk, T.; Koryszewska-Baginska, A.; Grynberg, M.; Nowak, A.; Cukrowska, B.; Kozáková, Hana; Bardowski, J.

    2016-01-01

    Roč. 8, č. 1 (2016), s. 202-217 ISSN 1759-6653 Institutional support: RVO:61388971 Keywords : adhesion * spaCBA pilus cluster * lactobacillus Subject RIV: EC - Immunology Impact factor: 3.979, year: 2016

  12. Principles of bioclimatic architecture applied at the project of spa center at Stara Planina mountain

    Directory of Open Access Journals (Sweden)

    Marić Igor

    2011-01-01

    Full Text Available Application of bioclimatic parameters in the design of tourist objects is an important factor for reducing energy consumption and preserving the environment. It represents the response to constant changing of climate conditions. Given the fact that development of tourism has negative consequences on the environment, it is necessary to examine the way design process can affect the reduction of energy and environmental pollution. This paper analyzes the principles of bioclimatic planning and design of the Spa Center at the Balkan Mountain that is one of the most valuable ecosystems in Serbia. Adaptation to the existing climate change was analyzed on two levels. The first level was urban factors that include analysis of local climate and environment that affect the positioning of the object and preliminary form. The second level was architecture factors with technical and technological solutions that can be achieved through the application of climate and energy responsible designing. Final analyses indicate that the bioclimatic approach is necessary in the initial stage of setting preliminary design for the building, because later it would take more effort to install technology that requires time and the whole process makes much more expensive. The work indicates that the energy needs of optimized Spa center like represented, from the very beginning of planning and designing, can be drastically reduced.

  13. The role of open-air inhalatoria in the air quality improvement in spa towns.

    Science.gov (United States)

    Burkowska-But, Aleksandra; Kalwasińska, Agnieszka; Brzezinska, Maria Swiontek

    2014-08-01

    The present study was aimed at evaluating microbiological contamination of air in Ciechocinek and Inowrocław - Polish lowland spa towns. Additionally, the impact of open-air inhalatoria on the quality of air was evaluated. Air samples were collected seasonally in the urban areas, in the recreation areas and in the vicinity of inhalatoria in both towns using impaction. The numbers of mesophilic bacteria, staphylococci, hemolytic bacteria and actinomycetes were determined on media according to the Polish Standard PN-86/Z-04111/02. The number of moulds was determined on media according to the Polish Standard PN-86/Z-04111/03. While the highest numbers of microorganisms were noted at the sites located in the urban areas, the lowest numbers were noted in the vicinity of the open-air inhalatoria. In all the investigated air samples the values of bioaerosol concentrations were below the recommended TLVs (≤ 5000 CFU×m(-3) for both bacteria and fungi in outdoor environments). Location of the sampling site was invariably a decisive factor in determining the number of microorganisms in the air. The aerosol which is formed in the open-air inhalatoria has a positive influence on microbiological air quality. Owing to a unique microclimate and low air contamination, Ciechocinek and Inowrocław comply with all necessary requirements set for health resorts specializing in treating upper respiratory tract infections.

  14. [The spa-and-health resort-based rehabilitation of the patients presenting with frequently recurring erosive and ulcerative lesions in the oesophagus, stomach, and duodenum in the phase of subsiding exacerbation].

    Science.gov (United States)

    Efimenko, N V; Kaĭsinova, A S

    2014-01-01

    To develop a new medical technology for the spa-and-health resort-based treatment of the patients presenting with frequently recurring erosive and ulcerative lesions in the oesophagus, stomach, and duodenum in the phase of subsiding exacerbation. A total of 100 patients presenting with frequently recurring erosive and ulcerative lesions in the oesophagus, stomach, and duodenum in the phase of subsiding exacerbation were available for the examination that included detailed investigations of the clinical picture, characteristics of the immune status, and psychological testing before and after a course of the spa-and-health resort-based treatment. The effectiveness of two therapeutic modalities was evaluated. One of them (control) prescribed to 50 patients consisted of standard antiulcer pharmacotherapy in combination with Essentuki Novaya drinking mineral water and carbon dioxide mineral baths, the other given to 50 patients included radon baths instead of carbon dioxide mineral baths. The combined application of drinking mineral waters, radon baths, and standard antiulcer pharmacotherapy produced the most conspicuous clinical effect in the framework of spa-and-health resort-based rehabilitation of the patients presenting with frequently recurring erosive and ulcerative lesions in the oesophagus, stomach, and duodenum in the phase of subsiding exacerbation as confirmed by positive dynamics of their psychoemotional status in 97.7% of the cases, regression of pain syndrome (91.5%), and improvement of humoral and cellular immunity (94%). An important result of the spa-and-health resort-based rehabilitation is the intensification of the reparative processes in gastroduodenal mucosa responsible for the healing of ulcers and erosions in 94.7% of the patients. The spa-and-health resort-based rehabilitation is a pathogenetically sound and efficacious approach to the management of the patients presenting with frequently recurring erosive and ulcerative lesions in the

  15. Tourist phenomenon in Geoagiu Spa region within the Central Metaliferi Mountains

    Directory of Open Access Journals (Sweden)

    Dombay Ştefan

    2010-01-01

    Full Text Available The Central Metaliferi Mountains, situated in south-central side of the Apuseni Mountains, have a variety of natural and anthropic touristic potential, but, unfortunately, less known and not enough exploited. After conducting a survey in Geoagiu Spa we specifically recommend the following: increased number of one day tours, which are the main tourist destination in the region, many tours for visiting the major centers of cultural - historical monuments related to our past history, granting economic incentives for organizer of youth groups to attract the youth, diversification of tourist routes with thematic actions: curiosities of nature, environment, organizing sports events with different timetable covering all seasons and all series, attracting local and foreign investors by providing tax incentives and financial programs introducing touristic resort in the international circuit. .

  16. A qualitative study of how to create supportive environments for the implementation of in-class-activities in middle school

    DEFF Research Database (Denmark)

    Holt, Anne-Didde; Smedegaard, Søren; Christiansen, Lars Breum Skov

    Purpose School physical activity (SPA) holds the potential to benefit children’s psychosocial well-being. PA can positively influence mental health through social connectedness, physical self-perception, and improvements in emotions. For such reasons, in-class-activities (ICA) (e.g. energizers...... of lessons and inform them about the following assignments to increase on-task behavior. Regarding creating a supportive environment, it was found that student motivation increased if they were involved in choosing, developing and instructing the ICA’s themselves. Furthermore, the variation in ICAs...... was important to satisfy different needs of the students, and the focus on social connectedness instead of competition was essential regarding the motivation of the less active students....

  17. How does spa treatment affect cardiovascular function and vascular endothelium in patients with generalized osteoarthritis? A pilot study through plasma asymmetric di-methyl arginine (ADMA) and L-arginine/ADMA ratio

    Science.gov (United States)

    Karaarslan, Fatih; Ozkuk, Kagan; Seringec Karabulut, Serap; Bekpinar, Seldag; Karagulle, Mufit Zeki; Erdogan, Nergis

    2018-05-01

    The study aims to investigate the effect of spa treatment on vascular endothelium and clinical symptoms of generalized osteoarthritis. Forty generalized osteoarthritis (GOA) patients referred to a government spa hospital, and 40 GOA patients followed on university hospital locomotor system disease ambulatory clinics were included as study and control groups, respectively. Study group received spa treatment including thermal water baths, physical therapy modalities, and exercises. Control group was followed with home exercises for 15 days. Plasma ADMA, L-arginine, L-arginine/ADMA ratio, routine blood analyses, 6-min walking test, including fingertip O2 saturation, systolic/diastolic blood pressure, and pulse rate, were measured at the beginning and at the end of treatment. Groups were evaluated with VAS pain, patient, and physician global assessment; HAQ; and WOMAC at the beginning, at the end, and after 1 month of treatment. In study group, L-arginine and L-arginine/ADMA ratio showed statistically significant increase after treatment. Plasma ADMA levels did not change. There is no significant difference in intergroup comparison. Study group displayed statistically significant improvements in all clinical parameters. The study showed that spa treatment does not cause any harm to the vascular endothelium through ADMA. Significant increase in plasma L-arginine and L-arginine/ADMA ratio suggests that balneotherapy may play a preventive role on cardiovascular diseases. Balneotherapy provides meaningful improvements on clinical parameters of GOA.

  18. How does spa treatment affect cardiovascular function and vascular endothelium in patients with generalized osteoarthritis? A pilot study through plasma asymmetric di-methyl arginine (ADMA) and L-arginine/ADMA ratio

    Science.gov (United States)

    Karaarslan, Fatih; Ozkuk, Kagan; Seringec Karabulut, Serap; Bekpinar, Seldag; Karagulle, Mufit Zeki; Erdogan, Nergis

    2017-12-01

    The study aims to investigate the effect of spa treatment on vascular endothelium and clinical symptoms of generalized osteoarthritis. Forty generalized osteoarthritis (GOA) patients referred to a government spa hospital, and 40 GOA patients followed on university hospital locomotor system disease ambulatory clinics were included as study and control groups, respectively. Study group received spa treatment including thermal water baths, physical therapy modalities, and exercises. Control group was followed with home exercises for 15 days. Plasma ADMA, L-arginine, L-arginine/ADMA ratio, routine blood analyses, 6-min walking test, including fingertip O2 saturation, systolic/diastolic blood pressure, and pulse rate, were measured at the beginning and at the end of treatment. Groups were evaluated with VAS pain, patient, and physician global assessment; HAQ; and WOMAC at the beginning, at the end, and after 1 month of treatment. In study group, L-arginine and L-arginine/ADMA ratio showed statistically significant increase after treatment. Plasma ADMA levels did not change. There is no significant difference in intergroup comparison. Study group displayed statistically significant improvements in all clinical parameters. The study showed that spa treatment does not cause any harm to the vascular endothelium through ADMA. Significant increase in plasma L-arginine and L-arginine/ADMA ratio suggests that balneotherapy may play a preventive role on cardiovascular diseases. Balneotherapy provides meaningful improvements on clinical parameters of GOA.

  19. Impact of serum SP-A and SP-D levels on comparison and prognosis of idiopathic pulmonary fibrosis: A systematic review and meta-analysis.

    Science.gov (United States)

    Wang, Kai; Ju, Qing; Cao, Jing; Tang, Wenze; Zhang, Jian

    2017-06-01

    Idiopathic pulmonary fibrosis (IPF) has a poor prognosis in general; however, it is heterogeneous to detect relative biomarkers for predicting the disease progression. Serum biomarkers can be conveniently collected to detect and help to differentially diagnose IPF and predict IPF prognosis. This meta-analysis aimed to evaluate the use of serum surfactant proteins A and D (SP-A and SP-D) for differential diagnosis and prognosis of IPF. Relevant articles were searched in PubMed, Embase, and Chinese National Knowledge Infrastructure databases and reviewed by 2 independent readers. Standard mean difference (SMD) and 95% confidence interval (CI) were calculated to assess the difference in serum levels of SP-A/D among patients with IPF, when compared to patients with non-IPF interstitial lung disease (ILD), pulmonary infection, and healthy control. Hazard ratio (HR) and 95% CI were used to compare the relative risk of mortality. Twenty-one articles (totalling 1289 IPF patients) were included in final meta-analysis. Serum SP-A levels were significantly higher in patients with IPF than in patients with non-IPF ILD (SMD: 1.108 [0.584, 1.632], P infection (SMD: 1.320 [0.999, 1.640], P SMD: 2.802 [1.901, 3.702], P SMD: 0.459 [-0.000, 0.919], P = .050). Serum SP-D levels were significantly higher in patients with IPF than in patients with pulmonary infection (SMD: 1.308 [0.813, 1.803], P SMD: 2.235 [1.739, 2.731], P < .001). Risk of death in patients with IPF and elevated serum SP-A was increased 39% compared to patients with low SP-A groups. Elevated SP-D increased risk by 111% when compared to low SP-D. In acute exacerbation of IPF, serum SP-A/D were higher than those in stable stage. The comparisons and prognosis might be different in Asian and Caucasian patients. Serum SP-A/D detection might be useful for differential diagnosis and prediction of survival in patients with IPF.

  20. Sex work and its associations with alcohol and methamphetamine use among female bar and spa workers in the Philippines.

    Science.gov (United States)

    Urada, Lianne A; Strathdee, Steffanie A; Morisky, Donald E; Schilling, Robert F; Simbulan, Nymia P; Estacio, Leonardo R; Raj, Anita

    2014-03-01

    To assess the prevalence of sex work and its associations with substance use among female bar/spa workers in the Philippines (N = 498), workers from 54 bar or spa venues in Metro Manila (2009-2010) were surveyed on demographics, drug/alcohol use, abuse history, and sex work. Their median age was 23 years and 35% engaged in sex work. Sex work was independently associated with methamphetamine use (19% vs 4%; adjusted odds ratio [AOR] =2.9, 95% confidence interval [CI] = 1.3-6.2), alcohol use with patrons (49% vs. 27%; AOR = 1.9, 95% CI = 1.1-3.4), and alcohol intoxication during sex (50% vs. 24%; AOR = 2.0, 95% CI = 1.2-3.5), but inversely associated with daily alcohol use (13% vs. 16%; AOR = 0.2, 95% CI = 0.1-0.5). Additional significant covariates included sexual abuse history, younger age, and not having a higher education. Findings suggest that interventions with sex workers in bars and spas should focus on methamphetamine use, alcohol use contexts, and violence victimization, to better meet the needs of this population.

  1. Theories and contemporary challenges of a global pasta leader: the case of Barilla SpA

    OpenAIRE

    Wolf, Ronald Scott

    2015-01-01

    Barilla Holding SpA (Barilla), a successful multinational foods manufacturing company with headquarters in Parma, Italy began with humble beginnings in 1877 (Barilla, 2014a) as a small bread and pasta shop -- Barilla is now a leading global sales player second only to private label brands, jumping from 9-12% of total market from the period 2009-2014 and is the dominant sales leader in both Italy and the US with 2014 sales of 900 and 800 US$ million respectively (Euromonitor, 2015) -- This pap...

  2. Exploring a model linking social physique anxiety, drive for muscularity, drive for thinness and self-esteem among adolescent boys and girls.

    Science.gov (United States)

    Brunet, Jennifer; Sabiston, Catherine M; Dorsch, Kim D; McCreary, Donald R

    2010-03-01

    This study examined gender differences on body image measures, and tested a model where self-esteem influences social physique anxiety (SPA), which in turn influences drive for muscularity and drive for thinness in a sample of adolescents (N=329; 58% boys). Multi-group invariance analyses indicated that the measurement and structural models were partially invariant for boys and girls, allowing for gender comparisons. Results indicated that boys reported significantly lower drive for thinness and SPA, and higher drive for muscularity and self-esteem compared to girls. The measurement and structural models were an adequate fit for the total sample. Findings supported the proposed sequence in which self-esteem significantly influenced SPA, and SPA significantly influenced the drives for muscularity and thinness. Interventions aimed at decreasing SPA, by promoting self-esteem, may be helpful in decreasing adolescent boys' and girls' drive for muscularity and thinness. Copyright 2009 Elsevier Ltd. All rights reserved.

  3. [The toxic complications of hydrogen sulfide-based balneotherapy in the spa and health resort practice].

    Science.gov (United States)

    Khodasevich, L S

    2015-01-01

    The present literature review was designed to consider the toxic complications of hydrogen sulfide-based balneotherapy encountered in the spa and health resort practice that should actually be regarded as hydrogen sulfide intoxication taking into consideration that their severity depends on the route through which the toxicant enters the body, its concentration in the therapeutic bath, and the overall duration of balneotherapy. Although such complications rarely occur in everyday practice, they may constitute a threat to the patient's health which implies the necessity of adequate measures for their prevention.

  4. Interaction between the Stress Phase Angle (SPA and the Oscillatory Shear Index (OSI Affects Endothelial Cell Gene Expression.

    Directory of Open Access Journals (Sweden)

    Ronny Amaya

    Full Text Available Hemodynamic forces play an important role in the non-uniform distribution of atherosclerotic lesions. Endothelial cells are exposed simultaneously to fluid wall shear stress (WSS and solid circumferential stress (CS. Due to variations in impedance (global factors and geometric complexities (local factors in the arterial circulation a time lag arises between these two forces that can be characterized by the temporal phase angle between CS and WSS (stress phase angle-SPA. Asynchronous flows (SPA close to -180° that are most prominent in coronary arteries have been associated with localization of atherosclerosis. Reversing oscillatory flows characterized by an oscillatory shear index (OSI that is great than zero are also associated with atherosclerosis localization. In this study we examined the relationship between asynchronous flows and reversing flows in altering the expression of 37 genes relevant to atherosclerosis development. In the case of reversing oscillatory flow, we observed that the asynchronous condition upregulated 8 genes compared to synchronous hemodynamics, most of them proatherogenic. Upregulation of the pro-inflammatory transcription factor NFκB p65 was confirmed by western blot, and nuclear translocation of NFκB p65 was confirmed by immunofluorescence staining. A comparative study between non-reversing flow and reversing flow found that in the case of synchronous hemodynamics, reversing flow altered the expression of 11 genes, while in the case of asynchronous hemodynamics, reversing flow altered the expression of 17 genes. Reversing flow significantly upregulated protein expression of NFκB p65 for both synchronous and asynchronous conditions. Nuclear translocation of NFκB p65 was confirmed for synchronous and asynchronous conditions in the presence of flow reversal. These data suggest that asynchronous hemodynamics and reversing flow can elicit proatherogenic responses in endothelial cells compared to synchronous

  5. Lactobacillus rhamnosus GG and its SpaC pilus adhesin modulate inflammatory responsiveness and TLR-related gene expression in the fetal human gut

    NARCIS (Netherlands)

    Ganguli, K.; Collado, M.C.; Rautava, J.; Lu, L.; Satokari, R.M.; Ossowski, von I.; Reunanen, J.; Vos, de W.M.; Palva, A.; Isolauri, E.; Salminen, S.; Walker, W.A.; Rautava, S.

    2015-01-01

    BACKGROUND: Bacterial contact in utero modulates fetal and neonatal immune responses. Maternal probiotic supplementation reduces the risk of immune-mediated disease in the infant. We investigated the immunomodulatory properties of live Lactobacillus rhamnosus GG and its SpaC pilus adhesin in human

  6. Impact of serum SP-A and SP-D levels on comparison and prognosis of idiopathic pulmonary fibrosis

    OpenAIRE

    Wang, Kai; Ju, Qing; Cao, Jing; Tang, Wenze; Zhang, Jian

    2017-01-01

    Abstract Background and objective: Idiopathic pulmonary fibrosis (IPF) has a poor prognosis in general; however, it is heterogeneous to detect relative biomarkers for predicting the disease progression. Serum biomarkers can be conveniently collected to detect and help to differentially diagnose IPF and predict IPF prognosis. This meta-analysis aimed to evaluate the use of serum surfactant proteins A and D (SP-A and SP-D) for differential diagnosis and prognosis of IPF. Methods: Relevant artic...

  7. College Student Environmental Activism: How Experiences and Identities Influence Environmental Activism Approaches

    Science.gov (United States)

    King, Laura A. H.

    2016-01-01

    College student environmental activism is one way students civically engage in addressing social issues. This study explores the environmental activism of twelve college students and how their experiences outside of college and in college influenced their activism. In addition, how students' identities influenced their approach to activism was…

  8. Pollen grain morphology of Fabaceae in the Special Protection Area (SPA) Pau-de-Fruta, Diamantina, Minas Gerais, Brazil.

    Science.gov (United States)

    Luz, Cynthia F P da; Maki, Erica S; Horák-Terra, Ingrid; Vidal-Torrado, Pablo; Mendonça Filho, Carlos Victor

    2013-01-01

    The presented paper considered the pollen morphology of thirteen species belonging to seven genera of the Fabaceae family occurring in the Pau-de-Fruta Special Protection Area (SPA), Diamantina, state of Minas Gerais, Brazil. The pollen grains of six species of Chamaecrista [C. cathartica (Mart.) H.S. Irwin & Barneby, C. debilis Vogel, C. flexuosa (L.) Greene, C. hedysaroides (Vogel) H.S. Irwin & Barneby, C. glandulosa (L.) Greene, and C. papillata H.S. Irwin & Barneby] have a similar morphology, characterized by three long colporated apertures with a central constriction. The species share specific morphological features regarding pollen size, endoaperture type (circular, lalongate or lolongate) and SEM ornamentation patterns of the exine (rugulate with perforations or perforate). Andira fraxinifolia Benth., Dalbergia miscolobium Benth, Galactia martii DC, Periandra mediterranea (Vell.) Taub., Senna rugosa (G.Don) H.S. Irwin & Barneby and Zornia diphylla (L.) Pers showed different pollen types in small to large size; oblate spheroidal to prolate form; colpus or colporus apertures; circular, lalongate or lolongate endoapertures and distinctive SEM ornamentation patterns of the exine (perforate, microreticulate, reticulate or rugulate with perforations). Only Stryphnodendron adstringens (Mart.) Coville presents polyads. The pollen morphology variation of these species allowed the Fabaceae family to be characterized as eurypalynous in the SPA Pau-de-Fruta.

  9. From Source Water to Tap Water to Spa and Swimming Pool Water: Effects of Disinfectanta and Precursors and Implications for Exposure and Toxicity

    Science.gov (United States)

    Introduction The current study investigated the effect of different disinfection treatments on the disinfection by-products (DBPs) formed in finished drinking water vs. tap water vs. swimming pool water vs. spa waters. To this end, samples across the complete water pathway (untr...

  10. Effects of natural factors of Niška Banja spa on indexes of mobility of vertebral column in patients with ankylosing spondylitis

    Directory of Open Access Journals (Sweden)

    Nedović Jovan

    2009-01-01

    Full Text Available Introduction. Ankylosing spondilitis (AS is a disease from a group of seronegative spondyloarthropathies with the prevalence of 0.1% affecting mainly young males, which also gives sociomedical significance to the disease. Among all inflammatory arthropathies, AS is the most suitable for balneotherapy. Thermomineral water of the Niška Banja spa is homeothermic, oligomineral, alkaline, low radioactive radon water and also, in conjunction with mineral peloid, is considered to be optimal for this indication. Objective. Our aim was to investigate the effects of natural factors of the Niška Banja spa as a part of complex treatment on the indexes of mobility of the vertebral column in the patients with AS. Methods. The study enrolled 40 patients with the average age of 48.0±14.82 years and the average duration of disease of 16.9±6.42 years. Patients were treated with hydro- and peloid- otherapy during the average of 17.23±2.71 days. At the beginning and at the end of treatment, a number of indexes of spinal mobility were measured. The statistical significance of differences was calculated using the Student's t-test. Results. All of the measured indexes were better after balneotherapy reaching statistically significant differences in regard to the wall-to-occiput distance (p<0.05, the index of sagittal mobility of the cervical (p<0.05 and lumbar (p<0.005 spine. Conclusion. The application of natural factors of the Niška Banja spa during complex treatment of the patients with AS is accompanied with the objective increase of the spine mobility.

  11. Continuous Aerobic Training in Individualized Intensity Avoids Spontaneous Physical Activity Decline and Improves MCT1 Expression in Oxidative Muscle of Swimming Rats.

    Science.gov (United States)

    Scariot, Pedro P M; Manchado-Gobatto, Fúlvia de Barros; Torsoni, Adriana S; Dos Reis, Ivan G M; Beck, Wladimir R; Gobatto, Claudio A

    2016-01-01

    Although aerobic training has been shown to affect the lactate transport of skeletal muscle, there is no information concerning the effect of continuous aerobic training on spontaneous physical activity (SPA). Because every movement in daily life (i.e., SPA) is generated by skeletal muscle, we think that it is possible that an improvement of SPA could affect the physiological properties of muscle with regard to lactate transport. The aim of this study was to evaluate the effect of 12 weeks of continuous aerobic training in individualized intensity on SPA of rats and their gene expressions of monocarboxylate transporters (MCT) 1 and 4 in soleus (oxidative) and white gastrocnemius (glycolytic) muscles. We also analyzed the effect of continuous aerobic training on aerobic and anaerobic parameters using the lactate minimum test (LMT). Sixty-day-old rats were randomly divided into three groups: a baseline group in which rats were evaluated prior to initiation of the study; a control group (Co) in which rats were kept without any treatment during 12 weeks; and a chronic exercise group (Tr) in which rats swam for 40 min/day, 5 days/week at 80% of anaerobic threshold during 12 weeks. After the experimental period, SPA of rats was measured using a gravimetric method. Rats had their expression of MCTs determined by RT-PCR analysis. In essence, aerobic training is effective in maintaining SPA, but did not prevent the decline of aerobic capacity and anaerobic performance, leading us to propose that the decline of SPA is not fully attributed to a deterioration of physical properties. Changes in SPA were concomitant with changes in MCT1 expression in the soleus muscle of trained rats, suggestive of an additional adaptive response toward increased lactate clearance. This result is in line with our observation showing a better equilibrium on lactate production-remotion during the continuous exercise (LMT). We propose an approach to combat the decline of SPA of rats in their home

  12. Assessing the potential for raw meat to influence human colonization with Staphylococcus aureus.

    Science.gov (United States)

    Carrel, Margaret; Zhao, Chang; Thapaliya, Dipendra; Bitterman, Patrick; Kates, Ashley E; Hanson, Blake M; Smith, Tara C

    2017-09-07

    The role of household meat handling and consumption in the transfer of Staphylococcus aureus (S. aureus) from livestock to consumers is not well understood. Examining the similarity of S. aureus colonizing humans and S. aureus in meat from the stores in which those individuals shop can provide insight into the role of meat in human S. aureus colonization. S. aureus isolates were collected from individuals in rural and urban communities in Iowa (n = 3347) and contemporaneously from meat products in stores where participants report purchasing meat (n = 913). The staphylococcal protein A (spa) gene was sequenced for all isolates to determine a spa type. Morisita indices and Permutational Multivariate Analysis of Variance Using Distance Matrices (PERMANOVA) were used to determine the relationship between spa type composition among human samples and meat samples. spa type composition was significantly different between households and meat sampled from their associated grocery stores. spa types found in meat were not significantly different regardless of the store or county in which they were sampled. spa types in people also exhibit high similarity regardless of residential location in urban or rural counties. Such findings suggest meat is not an important source of S. aureus colonization in shoppers.

  13. Analisa Pengaruh Brand Image Terhadap Customer Loyalty Dengan Customer Satisfaction Sebagai Mediator Pada the Dreamland Luxury Villas and Spa, Bali.

    OpenAIRE

    Leliga, Felicia Juliani

    2013-01-01

    Penelitian ini dilakukan untuk mengetahui customer loyalty pada brand The Dreamland Luxury Villas and Spa, Bali melalui penilaian responden terhadap dimensi brand image yang terdiri dari brand strength, brand favorability, dan brand uniqueness, dengan menggunakan customer satisfaction sebagai variabel mediator. Dalam penelitian ini, penulis menggunakan metode kuantitatif dengan teknik partial least square (PLS). Dari hasil analisa, disimpulkan bahwa tidak ada pengaruh brand strength dan brand...

  14. A slow-forming isopeptide bond in the structure of the major pilin SpaD from Corynebacterium diphtheriae has implications for pilus assembly

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Hae Joo; Paterson, Neil G. [University of Auckland, Private Bag 92019, Auckland 1142 (New Zealand); Kim, Chae Un [Cornell University, Ithaca, NY 14853 (United States); Middleditch, Martin [University of Auckland, Private Bag 92019, Auckland 1142 (New Zealand); Chang, Chungyu; Ton-That, Hung [University of Texas–Houston Medical School, Houston, TX 77030 (United States); Baker, Edward N., E-mail: ted.baker@auckland.ac.nz [University of Auckland, Private Bag 92019, Auckland 1142 (New Zealand)

    2014-05-01

    Two crystal structures of the major pilin SpaD from C. diphtheriae have been determined at 1.87 and 2.5 Å resolution. The N-terminal domain is found to contain an isopeptide bond that forms slowly over time in the recombinant protein. Given its structural context, this provides insight into the relationship between internal isopeptide-bond formation and pilus assembly. The Gram-positive organism Corynebacterium diphtheriae, the cause of diphtheria in humans, expresses pili on its surface which it uses for adhesion and colonization of its host. These pili are covalent protein polymers composed of three types of pilin subunit that are assembled by specific sortase enzymes. A structural analysis of the major pilin SpaD, which forms the polymeric backbone of one of the three types of pilus expressed by C. diphtheriae, is reported. Mass-spectral and crystallographic analysis shows that SpaD contains three internal Lys–Asn isopeptide bonds. One of these, shown by mass spectrometry to be located in the N-terminal D1 domain of the protein, only forms slowly, implying an energy barrier to bond formation. Two crystal structures, of the full-length three-domain protein at 2.5 Å resolution and of a two-domain (D2-D3) construct at 1.87 Å resolution, show that each of the three Ig-like domains contains a single Lys–Asn isopeptide-bond cross-link, assumed to give mechanical stability as in other such pili. Additional stabilizing features include a disulfide bond in the D3 domain and a calcium-binding loop in D2. The N-terminal D1 domain is more flexible than the others and, by analogy with other major pilins of this type, the slow formation of its isopeptide bond can be attributed to its location adjacent to the lysine used in sortase-mediated polymerization during pilus assembly.

  15. Feasibility study for the installation of HVAC for a spa by means of energy recovery from thermal water. Pt. 2: Energy analysis

    Energy Technology Data Exchange (ETDEWEB)

    Tabares, J.L. Miguez [Universidad de Vigo, Dept. de Ingenieria Mecanica, Vigo (Spain); Alvarez, M. Gandara [ISOLUX Espana, Vigo (Spain); Gonzalez, L.M. Lopez [Universidad de La Rioja, Dept. de Ingenieria Mecanica, Logrono (Spain); Viar, P. Fernandez [Universidad de Oviedo, Dept. de Energia, Oviedo (Spain)

    2001-05-01

    The use of a low temperature geothermal spring together with the heat energy still contained in waste water from the different therapy systems installed in a spa (shower, jets, bathrooms, jacuzzis, pools, ventilation processes) can significantly reduce the operating and maintenance costs of the installation. This covers part of the air conditioning needs of the building and of the heating of thermal water to the appropriate temperature for therapeutic use. In the first part of the study, an analysis of the spring's situation was made, calculating the thermal water needs and presenting the consumption according to the operation schedule on different types of day. In this way, the contribution the spring was capable of giving was compared and the evolution of the thermal water in the tanks was studied. In the second part, the climatic conditions that the spa should meet are studied, along with the loads that it should support, the energy reclaimed from the different heat focuses and the repercussions on the final solution. (Author)

  16. [Quality management in a combined clinic - the quality management system according to DIN EN ISO 9001 of the The German Association of Spa Accommodation Resorts e. V. (VdKB)].

    Science.gov (United States)

    Eckert, H; Schulze, U

    2004-06-01

    The implementation of a quality system in health care organizations offers huge potentials for improvement and development. But the realization of such systems necessitates high investments, which small companies and family businesses often are unable to raise. The German Association of Spa Accommodation Resorts (VdKB) commissioned two consultants to develop a reasonably priced implementation concept of a DIN EN ISO 9001 quality system specially adjusted to small companies and family businesses in medical spa and rehabilitation services, which was successfully accredited in May 2003. This paper describes fundamental requirements in combine management systems, considers the pros and cons of management combines and demonstrates the practical realization of combine requirements on the example of the VdKB-combine system.

  17. Spa-Wellness Center as Part of the Hotel Facility

    Directory of Open Access Journals (Sweden)

    Milica Rančić

    2013-04-01

    Full Text Available Over the last decades “wellness spa” industry has experienced a boom around the world. The word “Wellness” has been formed by merging two words: “Well Being” + “fitness”, and appeared in the thirties of the last century in the United States. The primary objective of this movement is an ancient philosophy, according to which there ́s no fulfilled life without the assent of the physical and mental, also physical and spiritual. Hotel guests, today more than ever, want higher quality offer for their money. This means that wellness is today a very important criterion by which customers select hotels. For this reason it is necessary to pay great attention to the planning, design and construction of this part of the hotel facility. The subject of this paper is wellness and spa centers as part of the hotel facility. The task is to investigate and analyze elements of this space, to determine spatial areas of wellness center, as well as their relationships and spatial organization, in order to reach the goal - getting useful guidelines for planning quality wellness center. To all of this could be achieved, we must first go back to distant history where dating back the beginnings of wellness.

  18. Defining active sacroiliitis on magnetic resonance imaging (MRI) for classification of axial spondyloarthritis: a consensual approach by the ASAS/OMERACT MRI group

    DEFF Research Database (Denmark)

    Rudwaleit, M; Jurik, A G; Hermann, K-G A

    2009-01-01

    BACKGROUND: Magnetic resonance imaging (MRI) of sacroiliac joints has evolved as the most relevant imaging modality for diagnosis and classification of early axial spondyloarthritis (SpA) including early ankylosing spondylitis. OBJECTIVES: To identify and describe MRI findings in sacroiliitis and...... relevant for sacroiliitis have been defined by consensus by a group of rheumatologists and radiologists. These definitions should help in applying correctly the imaging feature "active sacroiliitis by MRI" in the new ASAS classification criteria for axial SpA.......BACKGROUND: Magnetic resonance imaging (MRI) of sacroiliac joints has evolved as the most relevant imaging modality for diagnosis and classification of early axial spondyloarthritis (SpA) including early ankylosing spondylitis. OBJECTIVES: To identify and describe MRI findings in sacroiliitis...... conditions which may mimic SpA. Descriptions of the pathological findings and technical requirements for the appropriate acquisition were formulated. In a consensual approach MRI findings considered to be essential for sacroiliitis were defined. RESULTS: Active inflammatory lesions such as bone marrow oedema...

  19. [Study on influence between activated carbon property and immobilized biological activated carbon purification effect].

    Science.gov (United States)

    Wang, Guang-zhi; Li, Wei-guang; He, Wen-jie; Han, Hong-da; Ding, Chi; Ma, Xiao-na; Qu, Yan-ming

    2006-10-01

    By means of immobilizing five kinds of activated carbon, we studied the influence between the chief activated carbon property items and immobilized bioactivated carbon (IBAC) purification effect with the correlation analysis. The result shows that the activated carbon property items which the correlation coefficient is up 0.7 include molasses, abrasion number, hardness, tannin, uniform coefficient, mean particle diameter and effective particle diameter; the activated carbon property items which the correlation coefficient is up 0.5 include pH, iodine, butane and tetrachloride. In succession, the partial correlation analysis shows that activated carbon property items mostly influencing on IBAC purification effect include molasses, hardness, abrasion number, uniform coefficient, mean particle diameter and effective particle diameter. The causation of these property items bringing influence on IBAC purification is that the activated carbon holes distribution (representative activated carbon property item is molasses) provides inhabitable location and adjust food for the dominance bacteria; the mechanical resist-crash property of activated carbon (representative activated carbon property items: abrasion number and hardness) have influence on the stability of biofilm; and the particle diameter size and distribution of activated carbon (representative activated carbon property items: uniform coefficient, mean particle diameter and effective particle diameter) can directly affect the force of water in IBAC filter bed, which brings influence on the dominance bacteria immobilizing on activated carbon.

  20. Continuous Aerobic Training in Individualized Intensity Avoids Spontaneous Physical Activity Decline and Improves MCT1 Expression in Oxidative Muscle of Swimming Rats

    Directory of Open Access Journals (Sweden)

    Pedro Paulo Menezes Scariot

    2016-04-01

    Full Text Available Although aerobic training has been shown to affect the lactate transport of skeletal muscle, there is no information concerning the effect of continuous aerobic training on spontaneous physical activity (SPA. Because every movement in daily life (i.e. SPA is generated by skeletal muscle, we think that it is possible that an improvement of SPA could affect the physiological properties of muscle with regard to lactate transport. The aim of this study was to evaluate the effect of 12 weeks of continuous aerobic training in individualized intensity on SPA of rats and their gene expressions of monocarboxylate transporters (MCT 1 and 4 in soleus (oxidative and white gastrocnemius (glycolytic muscles. We also analyzed the effect of continuous aerobic training on aerobic and anaerobic parameters using the lactate minimum test (LMT. 60-day-old rats were randomly divided into three groups: a baseline group in which rats were evaluated prior to initiation of the study; a control group (Co in which rats were kept without any treatment during 12 weeks; and a chronic exercise group (Tr in which rats swam for 40min/day, 5 days/week at 80% of anaerobic threshold during 12 weeks. After the experimental period, SPA of rats was measured using a gravimetric method. Rats had their expression of MCTs determined by RT-PCR analysis. In essence, aerobic training is effective in maintaining SPA, but did not prevent the decline of aerobic capacity and anaerobic performance, leading us to propose that the decline of SPA is not fully attributed to a deterioration of physical properties. Changes in SPA were concomitant with changes in MCT1 expression in the soleus muscle of trained rats, suggestive of an additional adaptive response toward increased lactate clearance. This result is in line with our observation showing a better equilibrium on lactate production-remotion during the continuous exercise (LMT. We propose an approach to combat the decline of SPA of rats in their

  1. Feasibility study for the installation of HVAC for a spa by means of energy recovery from thermal water. Pt. 1: Analysis of conditions

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, L.M. Lopez [Universidad de La Rioja, Dept. de Ingenieria Mecanica, Logrono (Spain); Tabares, J.L. Miguez; Viar, P. Fernandez [Universidad de Oviedo, E.T.S. Ingegieros de Minas, Oviedo (Spain); Alvarez, M. Gandara [ISOLUX Galicia, Vigo (Spain)

    2001-05-01

    The use of a low temperature geothermal spring together with the heat energy still contained in waste water from the different therapy systems installed in a spa (shower, jets, bathrooms, Jacuzzis, pools, ventilation processes) can significantly reduce the operating and maintenance costs of the installation, covering part of the air conditioning needs of the building and the heating of thermal water to the appropriate temperature for therapeutic use. The object of the present work is to study the possible energy use of two sources of thermal hot water (spring and waste water) by restructuring of the existing spa so that it is more efficient from both a technical and economic point of view. In this first part, hot water needs are calculated and consumption presented according to the operation schedule on different types of day. Comparison is then made with the contribution that the spring is capable of making and the evolution of the thermal water in the tanks is studied. In a second work, energy and economic analyses will be presented. (Author)

  2. Defining active sacroiliitis on MRI for classification of axial spondyloarthritis: update by the ASAS MRI working group

    DEFF Research Database (Denmark)

    Lambert, Robert G W; Bakker, Pauline A C; van der Heijde, Désirée

    2016-01-01

    OBJECTIVES: To review and update the existing definition of a positive MRI for classification of axial spondyloarthritis (SpA). METHODS: The Assessment in SpondyloArthritis International Society (ASAS) MRI working group conducted a consensus exercise to review the definition of a positive MRI...... for inclusion in the ASAS classification criteria of axial SpA. Existing definitions and new data relevant to the MRI diagnosis and classification of sacroiliitis and spondylitis in axial SpA, published since the ASAS definition first appeared in print in 2009, were reviewed and discussed. The precise wording...... of the existing definition was examined in detail and the data and a draft proposal were presented to and voted on by the ASAS membership. RESULTS: The clear presence of bone marrow oedema on MRI in subchondral bone is still considered to be the defining observation that determines the presence of active...

  3. [Marketing macroenvironment of a sanatorium and spa facility as a study object and a factor of strategic decision making].

    Science.gov (United States)

    Babaskin, D V

    2009-01-01

    Analysis of marketing macroenvironment is an important stage in the formulation of the strategy for the development and operation of a therapeutic and preventive healthcare facility making possible rapid adjustment to sharply changing marketing conditions. The possibility of using expert evaluation for the analysis of the marketing macroenvironment of a sanatorium and spa facility and a concrete medical care service provided (peloidotherapy) is illustrated. The study covers five aspects of marketing macroenvironment, viz. socio-demographic, technological, economic, political and ecological.

  4. Historical analysis of rainfall-triggered rockfalls: the case study of the disaster of the ancient hydrothermal Sclafani Spa (Madonie Mts, northern-central Sicily, Italy) in 1851

    Science.gov (United States)

    Contino, Antonio; Bova, Patrizia; Esposito, Giuseppe; Giuffré, Ignazio; Monteleone, Salvatore

    2017-12-01

    In 1851, the region of Sicily experienced many rainstorm-induced landslides. On 13 March 1851, a rainstorm brought about a severe rockfall disaster near the small town of Sclafani (Madonie Mountains, northern-central Sicily, Italy). Rocks detached from the carbonate crest of Mt Sclafani (813 m above sea level) and fell downslope, causing the collapse of the ancient hydrothermal spa (about 430 m above sea level) and burying it. Fortunately, there were no injuries or victims. Given its geological, geomorphological and tectonic features, the calcareous-dolomitic and carbonate-siliciclastic relief of Mt Sclafani is extremely prone to landsliding. This study combines the findings of detailed geological and geomorphological field surveys and of a critical review of documentary data. A thorough analysis of documentary sources and historical maps made it possible to identify the location (previously unknown) of the ancient spa. The rockfall dynamics was reconstructed by comparing field reconnaissance data and documentary sources. The 1851 event reconstruction is an example of the application of an integrated methodological approach, which can yield a propaedeutic, yet meaningful picture of a natural disaster, paving the way for further research (e.g. slope failure susceptibility, future land-use planning, protection of thermal springs and mitigation of the impact of similar disasters in this area). Indeed, the intensification of extreme weather events, caused by global warming induced by climate change, has increased the risk of recurrence of a catastrophic event, like that of the ancient Sclafani spa, which is always a potential threat.

  5. Responsiveness of the Ankylosing Spondylitis Disease Activity Score (ASDAS) and clinical and MRI measures of disease activity in a 1-year follow-up study of patients with axial spondyloarthritis treated with tumour necrosis factor alpha inhibitors

    DEFF Research Database (Denmark)

    Pedersen, Susanne Juhl; Sørensen, Inge Juul; Hermann, Kay-Geert A

    2010-01-01

    To investigate construct validity and responsiveness of the novel ankylosing spondylitis (AS) disease activity score (ASDAS) in patients with spondyloarthritis (SpA).......To investigate construct validity and responsiveness of the novel ankylosing spondylitis (AS) disease activity score (ASDAS) in patients with spondyloarthritis (SpA)....

  6. Proceedings of international conference dedicated to the seventieth anniversary of Physical-technical institute, SPA 'Physics-Sun' 'Fundamental and applied problems of physics'

    International Nuclear Information System (INIS)

    Lutpullaev, S.L.; Atabaev, I.G.; Abdurakhmanov, A.A.

    2013-11-01

    The International conference dedicated to the seventieth anniversary of Physical-technical institute, SPA 'Physics-Sun' 'Fundamental and applied problems of physics' was held on 14-15 November, 2013 in Tashkent, Uzbekistan. Specialists discussed various aspects of modern problems of relativistic nuclear physics and physics of atomic nuclei, solid state physics, various applications of new materials. More than 225 talks were presented in the meeting. (k.m.)

  7. Comparative live-cell imaging analyses of SPA-2, BUD-6 and BNI-1 in Neurospora crassa reveal novel features of the filamentous fungal polarisome.

    Directory of Open Access Journals (Sweden)

    Alexander Lichius

    Full Text Available A key multiprotein complex involved in regulating the actin cytoskeleton and secretory machinery required for polarized growth in fungi, is the polarisome. Recognized core constituents in budding yeast are the proteins Spa2, Pea2, Aip3/Bud6, and the key effector Bni1. Multicellular fungi display a more complex polarized morphogenesis than yeasts, suggesting that the filamentous fungal polarisome might fulfill additional functions. In this study, we compared the subcellular organization and dynamics of the putative polarisome components BUD-6 and BNI-1 with those of the bona fide polarisome marker SPA-2 at various developmental stages of Neurospora crassa. All three proteins exhibited a yeast-like polarisome configuration during polarized germ tube growth, cell fusion, septal pore plugging and tip repolarization. However, the localization patterns of all three proteins showed spatiotemporally distinct characteristics during the establishment of new polar axes, septum formation and cytokinesis, and maintained hyphal tip growth. Most notably, in vegetative hyphal tips BUD-6 accumulated as a subapical cloud excluded from the Spitzenkörper (Spk, whereas BNI-1 and SPA-2 partially colocalized with the Spk and the tip apex. Novel roles during septal plugging and cytokinesis, connected to the reinitiation of tip growth upon physical injury and conidial maturation, were identified for BUD-6 and BNI-1, respectively. Phenotypic analyses of gene deletion mutants revealed additional functions for BUD-6 and BNI-1 in cell fusion regulation, and the maintenance of Spk integrity. Considered together, our findings reveal novel polarisome-independent functions of BUD-6 and BNI-1 in Neurospora, but also suggest that all three proteins cooperate at plugged septal pores, and their complex arrangement within the apical dome of mature hypha might represent a novel aspect of filamentous fungal polarisome architecture.

  8. Decreased plasma levels of soluble CD18 link leukocyte infiltration with disease activity in spondyloarthritis

    DEFF Research Database (Denmark)

    Kragstrup, Tue Wenzel; Jalilian, Babak; Hvid, Malene

    2014-01-01

    of arthritis patients to have anti-inflammatory functions. Here, we study the mechanisms for these alterations and their association with SpA disease activity. METHODS: Plasma levels of sCD18 in a study population with 84 SpA patients and matched healthy controls were analyzed with a time resolved......A patients compared with healthy volunteers (P levels in the HLA-B27-positive subgroup (P levels exhibited an inverse correlation with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) (P level of morning...... immunoflourometric assay (TRIFMA). Binding of sCD18 to endothelial cells and fibroblast-like synovial cells (FLS) was studied with confocal microscopy. Shedding of CD18 from peripheral blood mononuclear cells (PBMC) was studied with flow cytometry and TRIFMA. RESULTS: Plasma levels of sCD18 were decreased in Sp...

  9. Data showing non-conventional HLA-B27 expression in axial joints and gut tissue from B27 transgenic rats, and in frozen and paraffin-fixed synovial SpA tissue

    Directory of Open Access Journals (Sweden)

    Oliwia Rysnik

    2016-12-01

    Full Text Available Data is presented showing expression of non-conventional (NC heavy chain forms of B27 in synovial tissues from SpA patients. Data is presented showing the expression patterns of NC-B27 in joint, gastrointestinal and lymphoid tissues from B27 transgenic (TG1 rats with M. tuberculosis-induced SpA. Expression of NC-B27 was determined by immunohistochemistry and flow cytometry using HC10 and HD6 antibodies. These data are the extension of the data presented and discussed in “Non-conventional forms of HLA-B27 are expressed in Spondyloarthritis joints and gut tissue” (O. Rysnik, K. McHugh, L. M. van Duivenvoorde, M. N. van Tok, G. Guggino, J. D. Taurog, S. Kollnberger, F. Ciccia, D. L. Baeten, P. Bowness, 2016 [1].

  10. Topographic Transmissions and How To Talk About Them: The Case of the Southern Spa in Nineteenth-Century Russian Fiction

    Directory of Open Access Journals (Sweden)

    Benjamin Morgan

    2014-10-01

    Full Text Available The Caucasian spa resort is a significant setting in Russian literature of the nineteenth century. This paper will trace the origins and evolution of Russian fictional writing about watering places like Piatigorsk and Kislovodsk from romanticism until the turn of the twentieth century. At the same time it will consider the semiotic theories of Iurii Lotman’s Tartu-Moscow School and the ‘transtextual’ apparatus of the French narratologist Gérard Genette as ‘toolboxes’ for work on place in narrative.

  11. Analýza konkurenčního prostředí lázeňských služeb v Luhačovicích

    OpenAIRE

    Švarcová, Kristýna

    2012-01-01

    The subject of this diploma thesis is "Analysis of the competitive enviroment of the spa services in Luhačovice". The main aim of the thesis is comparison of spa services of different spa facilities operating in Luhačovice and choose the best provider of the services. The PEST analysis was used for reaching the main aim which included political, economic, social and technological indicators that influenced most of businesses in spa tourism. The another step was to analyse internal competitive...

  12. Effect of spring water on the radon concentration in the air at Masutomi spa in Yamanashi Prefecture, Japan

    International Nuclear Information System (INIS)

    Inagaki, Masayo; Koga, Taeko; Morishima, Hiroshige; Kimura, Shojiro; Ohta, Masatoshi

    2012-01-01

    The concentrations of 222 Rn existing in air have been studied by using a convenient and highly sensitive Pico-rad detector system at Masutomi spa in Yamanashi Prefecture, Japan. The measurements in air were carried out indoors and outdoors during the winter of 2000 and the summers of 1999 and 2005. The concentrations of 222 Rn in spring water in this region were measured by the liquid scintillation method. The concentrations of natural radionuclides contained in soils surrounding spa areas were also examined by means of the γ-ray energy spectrometry technique using a Ge diode detector to investigate the correlation between the radionuclides contents and 222 Rn concentrations in air at each point of interest. The atmospheric 222 Rn concentrations in these areas were high, ranging from 5 Bq/m 3 to 2676 Bq/m 3 . The radon concentration at each hotel was high in the order of the bath room, the dressing room, the lobby, and the outdoor area near the hotel, with averages and standard deviations of the concentration of 441 ± 79 Bq/m 3 , 351 ± 283 Bq/m 3 , 121 ± 5 Bq/m 3 , and 23 ± 1 Bq/m 3 , respectively. The source of 222 Rn in the air in the bath room is more likely to be the spring water than the soil. The spring water plays carries the radon to the atmosphere. Our measurements indicated that the 222 Rn concentration in the air was affected by the 222 Rn concentration in spring water rather than that in soil. (author)

  13. [The spa and resort-based health-promoting treatment of the vehicle drivers suffering from duodenal ulcer disease: the effectiveness and safety].

    Science.gov (United States)

    El'garov, A A; Kalmykova, M A; El'garova, R M; Betuganova, L V; El'garov, M A

    2015-01-01

    To evaluate the effectiveness and the safety of the spa and resort-based health-promoting treatment of the vehicle drivers (VD) presenting with duodenal ulcer disease. A total of 67 men suffering from duodenal ulcer disease (DUD) were allocated to two groups. The patients of group 1 (n = 35) were given the courses of balneotherapy that included bromine-iodine mineral baths with a temperature of 36-37 degrees C (8-9 procedures 10-15 min long each every second day) in combination with 8-9 peloid applications to the epigastric region (temperature 38-40 degrees C for 10-15 min every second day). The patients of group 2 (n = 32) were given the similar courses of therapy that included nitric thermal mineral baths with a temperature of 36-37 degrees C (8-9 procedures 10-15 min long each every second day) in combination with 8-9 peloid applications to the epigastric region (38-40 degrees C for 10-15 min every second day). The effectiveness and safety of these balenotherapeutic procedures for the treatment of duodenal ulcer disease in the subjects of the study and control (n = 47) groups were evaluated based on the results of the routine clinical and endoscopic examination, psychological and psychophysiological tests, and the comparative analysis of medical aid appeal-ability and disability cases during twelve months. Dynamics of clinical and instrumental characteristics (subjective, objective, clinical, endoscopic, psychophysiological) suggested the improvement of the health status in 88.6% and 84.4% of the drivers with duodenum ulcer in the two study groups respectively. Some of the patients comprising group 1 showed significant negative dynamics of the operative reaction system while the patients of group 2 demonstrated the marked improvement of the professionally significant functions and properties (PSF&P). The comparative analysis of medical aid appealability, disability cases, frequency of relapses and complications revealed the favorable clinical course of duodenal

  14. Major results and lessons learned for performance assessments of spent fuel geological disposal: the SPA project

    International Nuclear Information System (INIS)

    Baudoin, P.; Serres, C.; Certes, C.; Gay, D.

    2001-01-01

    This paper presents a summary of the results obtained in the framework of the SPA (spent fuel disposal performance assessment) project. The project was undertaken by ENRESA, E; GRS, D; IPSN, F; NRG, NL; SCK.CEN, B and VTT, FIN between May 1996 and April 1999. Devoted to the study of spent fuel disposal in various host rock formations (clay, crystalline rocks and salt formation), it notably had the objective to evaluate the long-term performance of different repository systems and to identify the most influential elements. The variety of concepts, sites and scenarios considered in the framework of this project provides a wide range of information from which some general conclusions can be drawn. Focusing on the work done in the case of granite host rock formations, this paper describes the various approaches adopted and states the main sources of differences. It particularly stresses the differences related to the geosphere and biosphere modelling. For the geosphere modelling, ENRESA, GRS and VTT use one dimensional discrete approaches to model the migration of contaminants through the geosphere taking into account for matrix diffusion, whereas IPSN uses a three dimensional continuum approach based on a single porosity model. The comparison of the biosphere conversion factors shows the high influence on the calculated radionuclide dose contributions that can results from biosphere modelling assumptions. It notably points out the differences existing between a simplified ''water drinking'' approach as implemented by VTT and a more classical one in which a wider range of exposure pathways are taken into account. (orig.)

  15. Alcohol peer influence of participating in organized school activities: a network approach.

    Science.gov (United States)

    Fujimoto, Kayo; Valente, Thomas W

    2013-10-01

    This study compares the network influences on adolescent substance use from peers who coparticipated in school-sponsored organized activities (affiliation-based peer influence) with the influence both from their "nominated" friends (i.e., the adolescent named the alter as a friend), and only "reciprocated" friends (i.e., both adolescents mutually named each other as friends). The study also attempts to parse affiliation-based peer influence into the influence of both activity members who are also friends and those who are not, to address the potential confounding of these sources of peer influence. The study data consisted of a nationally representative sample of 12,551 adolescents in Grades 7-12 within 106 schools from the Add Health data. Ordinal logistic regression was conducted to estimate the effects of affiliation-based and friends influence on alcohol use and drinking frequency. Peer influence via organized activities (sports or clubs) with drinkers and the influence of friends who drink had significant effects on adolescent drinking. Peer influence through club activities with drinkers had a stronger effect on any drinking behavior than through sports activities with drinkers. After decomposing peer influence through activities by friendship status, influence through sport activities had a significant effect on drinking only when coparticipant drinkers were also reciprocated friends (but not nominated friends), whereas influence through club activities had a significant effect on drinking, regardless of friendship reciprocation. The design and implementation of school based substance use prevention and treatment programs should consider the contextual effects of school-sponsored activities. (PsycINFO Database Record (c) 2013 APA, all rights reserved).

  16. Balneotherapy for chronic plaque psoriasis at Comano spa in Trentino, Italy.

    Science.gov (United States)

    Peroni, Anna; Gisondi, Paolo; Zanoni, Mauro; Girolomoni, Giampiero

    2008-07-01

    Thermal therapy is used worldwide in the treatment of psoriasis but few controlled studies have evaluated its efficacy and safety. We studied the efficacy and safety of balneotherapy compared to photobalneotherapy performed at Comano spa in Trentino, Italy, in chronic plaque psoriasis in a prospective, nonrandomized, open study. Three hundred adult patients with mild to severe chronic plaque psoriasis were assigned to either balneotherapy or photobalneotherapy with daily narrow-band ultraviolet B for a mean period of 1 or 2 weeks, reflecting the times that most patients can dedicate to thermal therapy. Patients were evaluated at baseline and end of treatment for psoriasis area and severity index (PASI) and body surface area; self-administered PASI (SAPASI) and Skindex-29 were evaluated at the same times, and also at 4 months by a mailed questionnaire. One-week balneotherapy or photobalneotherapy resulted in a significant reduction in PASI score (11.54% +/- 2.76 and 12.76% +/- 3.79, respectively; mean +/- standard deviation; p balneotherapy alone, with PASI reduction of 19.8% +/- 24.5 and 13.5% +/- 23.1 (p balneotherapy and photobalneotherapy could thus be offered to patients willing to temporarily discontinue pharmacologic therapy or as adjuvant therapy.

  17. Presence of multiple spondyloarthritis (SpA) features is important but not sufficient for a diagnosis of axial spondyloarthritis: data from the SPondyloArthritis Caught Early (SPACE) cohort

    NARCIS (Netherlands)

    Ez-Zaitouni, Z.; Bakker, P. A. C.; van Lunteren, M.; Berg, I. J.; Landewe, R.; van Oosterhout, M.; Lorenzin, M.; van der Heijde, D.; van Gaalen, F. A.

    2017-01-01

    Objectives Concerns have been raised about overdiagnosis of axial spondyloarthritis (axSpA). We investigated whether patients with chronic back pain (CBP) of short duration and multiple SpA features are always diagnosed with axSpA by the rheumatologist, and to what extent fulfilment of the

  18. Hyperspectral Imaging and SPA-LDA Quantitative Analysis for Detection of Colon Cancer Tissue

    Science.gov (United States)

    Yuan, X.; Zhang, D.; Wang, Ch.; Dai, B.; Zhao, M.; Li, B.

    2018-05-01

    Hyperspectral imaging (HSI) has been demonstrated to provide a rapid, precise, and noninvasive method for cancer detection. However, because HSI contains many data, quantitative analysis is often necessary to distill information useful for distinguishing cancerous from normal tissue. To demonstrate that HSI with our proposed algorithm can make this distinction, we built a Vis-NIR HSI setup and made many spectral images of colon tissues, and then used a successive projection algorithm (SPA) to analyze the hyperspectral image data of the tissues. This was used to build an identification model based on linear discrimination analysis (LDA) using the relative reflectance values of the effective wavelengths. Other tissues were used as a prediction set to verify the reliability of the identification model. The results suggest that Vis-NIR hyperspectral images, together with the spectroscopic classification method, provide a new approach for reliable and safe diagnosis of colon cancer and could lead to advances in cancer diagnosis generally.

  19. Ideologically motivated activism: How activist groups influence corporate social change activities

    NARCIS (Netherlands)

    den Hond, F.; de Bakker, F.G.A.; Hickman, G. R.

    2010-01-01

    Using insights from the social movement literature and institutional change theory, we explore how activism influences corporate social change activities. As the responsibility for addressing a variety of social issues is transferred from the state to the private sector, activist groups increasingly

  20. Responsiveness of the Ankylosing Spondylitis Disease Activity Score (ASDAS), and clinical and magnetic resonance imaging measures of disease activity in a 1 year follow-up study of patients with axial spondyloarthritis treated with TNF-{alpha} inhibitors

    DEFF Research Database (Denmark)

    Pedersen, Susanne J; Sørensen, Inge J; Hermann, Kay-Geert A

    2010-01-01

    OBJECTIVES: To investigate construct validity and responsiveness of the novel ankylosing spondylitis disease activity score (ASDAS) in patients with spondyloarthritis (SpA). METHODS: In a 46 weeks prospective, longitudinal multi-center study of 60 SpA patients (80% men, median age 40 years (range...... 21-62)) treated with tumor-necrosis-factor-alpha (TNF-alpha) inhibitors (infliximab (n=41), etanercept (n=13), adalimumab (n=6)) responsiveness of ASDAS, conventional clinical measures of disease activity and treatment response, and the Berlin magnetic resonance imaging (MRI) sacroiliac joint (SIJ......) and lumbar spine inflammation scores were compared. RESULTS: After 22 weeks, 58.3% of the patients were clinical responders (50% or 20mm reduction in BASDAI). At baseline, clinical responders had significantly higher ASDAS (median 4.15 (range 1.98-6.04), p=0.008) compared with non-responders (2.99, 2...

  1. Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy

    NARCIS (Netherlands)

    Baeten, Dominique; Kruithof, Elli; de Rycke, Leen; Boots, Anemieke M.; Mielants, Herman; Veys, Eric M.; de Keyser, Filip

    2005-01-01

    Considering the relation between synovial inflammation and global disease activity in rheumatoid arthritis (RA) and the distinct but heterogeneous histology of spondyloarthropathy (SpA) synovitis, the present study analyzed whether histopathological features of synovium reflect specific phenotypes

  2. Beneficial effects of spa treatment on functional status and quality of life of patients with rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    Mustur Dušan

    2008-01-01

    Full Text Available INTRODUCTION Rheumatoid arthritis (RA is a chronic constantly deteriorating disease of unpredictable clinical course, with exacerbations, remissions and damaged joints. It leads to the loss of self-sufficiency, independence in performing many daily activities, decrease of working ability and invalidity. Beside physical factors, which are regarded as most responsible for the poorer quality of life of RA patients, psychological changes are also significant, such as the feeling of helplessness, hopelessness and depression. The goal of the treatment of patients with RA is to decrease illness symptoms, slow down the development of illness progression, improvement of physical functioning and provision of expert help to the RA patients to adapt to life. OBJECTIVE The aim of the study was to assess the influence of spa therapy on the functional condition and life quality of RA patients. METHODS The study involved 69 patients with RA (51 female and 18 male, on average aged 55.2±11.4 years, with illness duration 12.5±7.5 years, and were a part of a cohort from Norway, suffering of inflammatory rheumatism. All the patients came for four-week rehabilitation at the Institute for Physical Medicine, Rehabilitation and Rheumatology "Dr. Simo Milošević" in Igalo, Montenegro. The RA patients underwent treatment with mud compresses, mud, mineral and pearl baths, as well as with underwater shower massage (balneotherapy kinesitherapy and certain forms of electrotherapy with analgesic effects. The evaluation was done on admission and after completed physical therapy when we assessed RA patients' functional condition and quality of life. The functional condition was determined using the Modified Health Assessment Questionnaire (MHAQ, and the quality of life using the Medical Outcomes Study Short Form 36-item Questionnaire (SF-36, which encompassed eight life domains. RESULTS After completion of 28-dayspa therapy, RA patients showed a significant improvement in

  3. Anti-TNF agents for the treatment of active non-radiographic axial spondyloarthritis

    Directory of Open Access Journals (Sweden)

    I. Olivieri

    2013-03-01

    Full Text Available The spondyloarthritis (SpA complex includes ankylosing spondylitis (AS, reactive arthritis, psoriatic arthritis, arthritis related to inflammatory bowel disease and forms that do not meet established criteria for these definite categories which are designated as undifferentiated SpA. In the early 1990s, two sets of classification criteria were suggested with the purpose to cover the whole clinical spectrum of SpA: the Amor criteria and the European Spondylarthropathy Study Group (ESSG criteria...

  4. Influence of mammal fossorial activity on the soil fermentative activity in conditions of metallurgical production

    Directory of Open Access Journals (Sweden)

    S. M. Kirienko

    2010-09-01

    Full Text Available Effect of mammal fossorial activity as an ecological factor of the soil genesis intensification is studied. Enzymatic activity of soil as its ability to demonstrate a catalytic effect for various compounds transformation is examined. Variability of soil urease activity in technogenic conditions with the participation of animals is shown. The positive influence of animals’ activity on the catalitic ability of the investigated soils was determined. The statistically significant characteristics which have an influence on the urease activity in soil are found out.

  5. Pre-feasibility study on the investment in a new SPA & wellness facility : Case Study: based on a hotel-restaurant in Germany

    OpenAIRE

    Jahn, Moritz

    2011-01-01

    The object of investigation has at the present a wellness facility which is however out-dated and does not longer support the general appearance. Therefore, a new investment has to be done which will be assessed with regard to its conceptual, economic and financial viability. In particular, the economic and financial viability of the new SPA & wellness facility by itself had to be assessed, as this is the main criteria for the principal. The extent of the pre-feasibility study is a limited ve...

  6. Can activity support influence image of a street?

    Science.gov (United States)

    Tamiami Fachrudin, Hilma

    2018-03-01

    Activity support may affect the formation of the image of a corridor and street. Form, place, and character of activity support in an area will have the function attraction and usefulness of its activities. The aim of this research is to analyze how the influence of activity support on the image of a street, in this case, Dr.Mansyur street which located in front of Universitas Sumatera Utara. Along the street, there are various activities that conducted from morning until evening. The method used is a quantitative method with observation and questionnaire techniques. A population of this study is visitors and students of architecture department from Universitas Sumatera Utara (USU) with sample number is 100 respondents for visitors and 100 respondents for students. Independent variables are activity support factors that consist of the type of activity, form, color, dimension, material, position and lighting. The dependent variable is imageability by [1]. Data were analyzed using logistic regression analysis. The results show that activity support influences image Dr. Mansyur street that has an image as a campus and culinary area and easy to identify.

  7. A grounded theory of how social support influences physical activity in adolescent girls

    Science.gov (United States)

    Fawkner, Samantha

    2018-01-01

    ABSTRACT Purpose: Adolescent girls are not sufficiently active to achieve health benefits. Social support from friends and family has been positively associated with physical activity in adolescent girls; however it is unclear how social support influences physical activity behaviour. This study aimed to develop a grounded theory of how social support influences physical activity in adolescent girls. Methods: A qualitative, constructivist grounded theory approach was adopted. Individual interviews explored adolescent girls’ perspectives of how significant others’ influenced their physical activity through providing social support, and through modelling physical activity. Results: Participants perceived social support to influence physical activity behaviour through performance improvements, self-efficacy, enjoyment, motivation and by enabling physical activity. Improvements in performance and self-efficacy were also linked to motivation to be active. Girls perceived modelling to influence behaviour through providing opportunities for them to be physically active, and by inspiring them to be active. Conclusion: The grounded theory outlines adolescent girls’ perceptions of how significant others influence their physical activity and provides a framework for future research examining the role of social support on physical activity. PMID:29405881

  8. A grounded theory of how social support influences physical activity in adolescent girls.

    Science.gov (United States)

    Laird, Yvonne; Fawkner, Samantha; Niven, Ailsa

    2018-12-01

    Adolescent girls are not sufficiently active to achieve health benefits. Social support from friends and family has been positively associated with physical activity in adolescent girls; however it is unclear how social support influences physical activity behaviour. This study aimed to develop a grounded theory of how social support influences physical activity in adolescent girls. A qualitative, constructivist grounded theory approach was adopted. Individual interviews explored adolescent girls' perspectives of how significant others' influenced their physical activity through providing social support, and through modelling physical activity. Participants perceived social support to influence physical activity behaviour through performance improvements, self-efficacy, enjoyment, motivation and by enabling physical activity. Improvements in performance and self-efficacy were also linked to motivation to be active. Girls perceived modelling to influence behaviour through providing opportunities for them to be physically active, and by inspiring them to be active. The grounded theory outlines adolescent girls' perceptions of how significant others influence their physical activity and provides a framework for future research examining the role of social support on physical activity.

  9. Solar-energy-system performance-evaluation update: Wood Road School, Ballston Spa, New York, October 1982-April 1983

    Energy Technology Data Exchange (ETDEWEB)

    Kendall, P

    1983-01-01

    The Wood Road School Solar Project is a 216,000 square foot combined elementary and middle school in Ballston Spa, New York. The solar energy system supplies energy to the space heating and domestic hot water subsystems. Heat is collected by flat plate collector panels and stored in two storage tanks. Performance data are given for the system overall and for each of the four subsystems - energy collection, storage, space heating, and domestic hot water. Data are also provided on operating energy, energy savings, and weather conditions. Design and actual system solar fraction are compared, and percentage of incident solar energy and collected solar energy utilized are given. Also given are building loads analysis, system thermal losses, and system coefficient of performance. (LEW)

  10. Metabolic activity, urease production, antibiotic resistance and virulence in dual species biofilms of Staphylococcus epidermidis and Staphylococcus aureus

    Science.gov (United States)

    Vandecandelaere, Ilse; Van Nieuwerburgh, Filip; Deforce, Dieter

    2017-01-01

    In this paper, the metabolic activity in single and dual species biofilms of Staphylococcus epidermidis and Staphylococcus aureus isolates was investigated. Our results demonstrated that there was less metabolic activity in dual species biofilms compared to S. aureus biofilms. However, this was not observed if S. aureus and S. epidermidis were obtained from the same sample. The largest effect on metabolic activity was observed in biofilms of S. aureus Mu50 and S. epidermidis ET-024. A transcriptomic analysis of these dual species biofilms showed that urease genes and genes encoding proteins involved in metabolism were downregulated in comparison to monospecies biofilms. These results were subsequently confirmed by phenotypic assays. As metabolic activity is related to acid production, the pH in dual species biofilms was slightly higher compared to S. aureus Mu50 biofilms. Our results showed that S. epidermidis ET-024 in dual species biofilms inhibits metabolic activity of S. aureus Mu50, leading to less acid production. As a consequence, less urease activity is required to compensate for low pH. Importantly, this effect was biofilm-specific. Also S. aureus Mu50 genes encoding virulence-associated proteins (Spa, SplF and Dps) were upregulated in dual species biofilms compared to monospecies biofilms and using Caenorhabditis elegans infection assays, we demonstrated that more nematodes survived when co-infected with S. epidermidis ET-024 and S. aureus mutants lacking functional spa, splF or dps genes, compared to nematodes infected with S. epidermidis ET-024 and wild- type S. aureus. Finally, S. epidermidis ET-024 genes encoding resistance to oxacillin, erythromycin and tobramycin were upregulated in dual species biofilms and increased resistance was subsequently confirmed. Our data indicate that both species in dual species biofilms of S. epidermidis and S. aureus influence each other’s behavior, but additional studies are required necessary to elucidate the exact

  11. The Activation Mechanism of Bi3+ Ions to Rutile Flotation in a Strong Acidic Environment

    Directory of Open Access Journals (Sweden)

    Wei Xiao

    2017-07-01

    Full Text Available Lead hydroxyl compounds are known as rutile flotation of the traditional activated component, but the optimum pH range for flotation is 2–3 using styryl phosphoric acid (SPA as collector, without lead hydroxyl compounds in slurry solution. In this study, Bi3+ ions as a novel activator was investigated. The results revealed that the presence of Bi3+ ions increased the surface potential, due to the specific adsorption of hydroxyl compounds, which greatly increases the adsorption capacity of SPA on the rutile surface. Bi3+ ions increased the activation sites through the form of hydroxyl species adsorbing on the rutile surface and occupying the steric position of the original Ca2+ ions. The proton substitution reaction occurred between the hydroxyl species of Bi3+ ions (Bi(OHn+(3−n and the hydroxylated rutile surface, producing the compounds of Ti-O-Bi2+. The micro-flotation tests results suggested that Bi3+ ions could improve the flotation recovery of rutile from 61% to 90%, and from 61% to 64% for Pb2+ ions.

  12. Increased IL-20 and IL-24 target osteoblasts and synovial monocytes in spondyloarthritis

    DEFF Research Database (Denmark)

    Kragstrup, Tue Wenzel; Andersen, Morten Nørgaard; Schiøttz-Christensen, Berit

    2017-01-01

    The pathogenesis of spondyloarthritis (SpA) involves activation of the innate immune system, inflammation and new bone formation. The two cytokines interleukin (IL)-20 and IL-24 have been shown to link innate immune activation and tissue homeostasis. We hypothesized that these two cytokines...... are secreted as part of activation of the innate immune system and affect bone homeostasis in SpA. IL-20 and IL-24 were measured in plasma from axial SpA patients (n = 83). Peripheral SpA patients (n = 16) were included for in-vitro cell culture studies. The plasma IL-20 and IL-24 levels were increased in Sp...

  13. Exercise Motivation and Social Physique Anxiety In Adolescents

    Directory of Open Access Journals (Sweden)

    Alvaro Sicilia

    2014-01-01

    Full Text Available Based on self-determination theory (SDT, the goal of this study was to analyze the relation between satisfaction of basic psychological needs, types of motivation to exercise, and social physique anxiety (SPA. Participants in the study were 398 secondary education students, aged between 12 and 19 years, who completed questionnaires that measured the variables of interest. The results of multiple mediation analysis revealed that satisfaction of the need for competence negatively predicted SPA, both directly and indirectly through the mediation of integrated, identified, and external regulations. Introjected regulation also positively predicted SPA. Gender and body mass index (BMI affected the relationships analyzed and were also shown to predict SPA. The results of this study further our understanding of the motivational process that explains SPA in adolescents within an exercise context, showing the positive influence of perceived competence and types of self-determined motivation to reduce SPA.

  14. Parental influences on adolescent physical activity: a longitudinal study

    Directory of Open Access Journals (Sweden)

    Ayala Guadalupe X

    2007-02-01

    Full Text Available Abstract Background Physical inactivity is increasing among adolescents in the U.S., especially among girls. Despite growing evidence that parents are an important influence on adolescent health, few longitudinal studies have explored the causal relationship between parental influence and physical activity. This study examines how the relationships between parental influences and adolescent physical activity differ by gender and tests whether these relationships are mediated by adolescents' self-esteem and depression. Methods Data are from the National Longitudinal Study of Adolescent Health. The sample includes 13,246 youth, grades 7 to 12, interviewed in 1995 and again 1 year later. Logit models were used to evaluate parental influences on achieving five or more bouts of moderate to vigorous physical activity per week [MVPA] and whether the relationship between parental influence and MVPA was mediated by adolescents' level of self-esteem and depression. Results Family cohesion, parent-child communication and parental engagement positively predicted MVPA for both genders one year later (odds ratios and 95% confidence intervals for females, 1.09 [1.05–1.12], 1.13 [1.07–1.19], 1.25 [1.17–1.33] and males, 1.08 [1.04–1.11], 1.14 [1.07–1.23], 1.23 [1.14–1.33], respectively; however, parental monitoring did not (odds ratio and confidence intervals for females and males, 1.02 [.97–1.07]. For both females and males, self-esteem mediated the relationship between parental influence and physical activity. Depressive symptoms were only a mediator among males. Females reported higher levels of parent-child communication and lower family cohesion compared with males. There were no gender differences in levels of parental monitoring and engagement. Females had significantly lower levels of self-esteem and higher levels of depressive symptoms than males. Conclusion Strategies to promote physical activity among adolescents should focus on

  15. Microscale ecotoxicity testing of Moselle river watershed (Lorraine Province, France sediments

    Directory of Open Access Journals (Sweden)

    Jean François Férard

    2015-06-01

    Full Text Available The ecotoxic potential of seven Moselle river watershed sediments was assessed with a battery of bioassays comprised of rapid phototrophic [LuminoTox solid phase (L-SPA and elutriate (L-ELU assays] and bacterial [Microtox solid phase assay (M-SPA] exposure tests, as well as with two micro-invertebrate solid phase tests conducted with Hydra attenuata (lethal and sublethal effects solid phase assay, HL-SPA and HSL-SPA and Chironomus riparius. Measured effects of sediments and their elutriates were varied and reflected responses that were ecotoxicity test-, endpoint- and site-dependent, suggesting some degree of risk toward benthic and water column organisms, respectively, at specific sites. Correlation analysis demonstrated that L-SPA and M-SPA ecotoxicity responses were significantly linked with the Hydra HSL-SPA assay, indicating their ability to predict ecotoxicity towards an invertebrate taxonomic group representing secondary consumers. While the L-SPA and M-SPA assays hold promise as rapid screens for sediment ecotoxicity, correlation analysis with grain size (L-SPA: r=-0.795, P=0.033; M-SPA: r=-0.73, P=0.07 points out that their responses can be influenced by the presence of fines (i.e., sediment particles ≤0.063 mm in size and that this information is essential to properly interpret ecotoxicity data generated with these assays. Finally, notable differences observed in trophic level sensitivities once again recall the importance of employing a test battery to adequately appraise the ecotoxicity of sediments.

  16. Diagnostics of the Factors Influencing the Export Activity of an Enterprise

    Directory of Open Access Journals (Sweden)

    Skrynkovskyy Ruslan M.

    2017-09-01

    Full Text Available The modern practice of doing business proves that a successful entrance of any enterprise to external (international markets depends on the level of its readiness for carrying out foreign economic activity. Under such circumstances, the process of targeted analysis and assessment of factors influencing the export activity of the enterprise is relevant, expedient and important. The aim of the article is the formation and development of theoretical and methodological bases for diagnosing factors influencing the export activity of an enterprise on the basis of theory and practice in the field of management and administration. It is found that the diagnostics should be understood as the process of identification, analysis and evaluation of influence (functional, dysfunctional of the factors (circumstances, conditions, etc. on the export activity of an enterprise in order to identify and solve problems (current, possible ones in the sphere of supply and implementation of specific actions (steps related to its entrance to external (international markets. It is determined that the key business indicators of the system for diagnosing the factors influencing the export activity of an enterprise are indicators reflecting the influence of the main factors on its export activity: level of fulfillment of obligations in terms of cost; level of conclusion of “expensive contracts”; share of renewed business contracts in the total number of contracts; level of satisfaction of claims; level of delivery variability. The prospect for further research in this scientific direction is developing a system of partial diagnostic goals of the integrated system of goals for conducting economic diagnostics of enterprises taking into account the diagnostics of factors influencing the export activity of an enterprise as a partial diagnostic goal.

  17. ADDING A NEW STEP WITH SPATIAL AUTOCORRELATION TO IMPROVE THE FOUR-STEP TRAVEL DEMAND MODEL WITH FEEDBACK FOR A DEVELOPING CITY

    Directory of Open Access Journals (Sweden)

    Xuesong FENG, Ph.D Candidate

    2009-01-01

    Full Text Available It is expected that improvement of transport networks could give rise to the change of spatial distributions of population-related factors and car ownership, which are expected to further influence travel demand. To properly reflect such an interdependence mechanism, an aggregate multinomial logit (A-MNL model was firstly applied to represent the spatial distributions of these exogenous variables of the travel demand model by reflecting the influence of transport networks. Next, the spatial autocorrelation analysis is introduced into the log-transformed A-MNL model (called SPA-MNL model. Thereafter, the SPA-MNL model is integrated into the four-step travel demand model with feedback (called 4-STEP model. As a result, an integrated travel demand model is newly developed and named as the SPA-STEP model. Using person trip data collected in Beijing, the performance of the SPA-STEP model is empirically compared with the 4-STEP model. It was proven that the SPA-STEP model is superior to the 4-STEP model in accuracy; most of the estimated parameters showed statistical differences in values. Moreover, though the results of the simulations to the same set of assumed scenarios by the 4-STEP model and the SPA-STEP model consistently suggested the same sustainable path for the future development of Beijing, it was found that the environmental sustainability and the traffic congestion for these scenarios were generally overestimated by the 4-STEP model compared with the corresponding analyses by the SPA-STEP model. Such differences were clearly generated by the introduction of the new modeling step with spatial autocorrelation.

  18. Genetic and environmental influences on the allocation of adolescent leisure time activities.

    Science.gov (United States)

    Haberstick, Brett C; Zeiger, Joanna S; Corley, Robin P

    2014-01-01

    There is a growing recognition of the importance of the out-of-school activities in which adolescents choose to participate. Youth activities vary widely in terms of specific activities and in time devoted to them but can generally be grouped by the type and total duration spent per type. We collected leisure time information using a 17-item leisure time questionnaire in a large sample of same- and opposite-sex adolescent twin pairs (N = 2847). Using both univariate and multivariate genetic models, we sought to determine the type and magnitude of genetic and environmental influences on the allocation of time toward different leisure times. Results indicated that both genetic and shared and nonshared environmental influences were important contributors to individual differences in physical, social, intellectual, family, and passive activities such as watching television. The magnitude of these influences differed between males and females. Environmental influences were the primary factors contributing to the covariation of different leisure time activities. Our results suggest the importance of heritable influences on the allocation of leisure time activity by adolescents and highlight the importance of environmental experiences in these choices.

  19. Creation of lung-targeted dexamethasone immunoliposome and its therapeutic effect on bleomycin-induced lung injury in rats.

    Directory of Open Access Journals (Sweden)

    Xue-Yuan Chen

    Full Text Available OBJECTIVE: Acute lung injury (ALI, is a major cause of morbidity and mortality, which is routinely treated with the administration of systemic glucocorticoids. The current study investigated the distribution and therapeutic effect of a dexamethasone(DXM-loaded immunoliposome (NLP functionalized with pulmonary surfactant protein A (SP-A antibody (SPA-DXM-NLP in an animal model. METHODS: DXM-NLP was prepared using film dispersion combined with extrusion techniques. SP-A antibody was used as the lung targeting agent. Tissue distribution of SPA-DXM-NLP was investigated in liver, spleen, kidney and lung tissue. The efficacy of SPA-DXM-NLP against lung injury was assessed in a rat model of bleomycin-induced acute lung injury. RESULTS: The SPA-DXM-NLP complex was successfully synthesized and the particles were stable at 4°C. Pulmonary dexamethasone levels were 40 times higher with SPA-DXM-NLP than conventional dexamethasone injection. Administration of SPA-DXM-NLP significantly attenuated lung injury and inflammation, decreased incidence of infection, and increased survival in animal models. CONCLUSIONS: The administration of SPA-DXM-NLP to animal models resulted in increased levels of DXM in the lungs, indicating active targeting. The efficacy against ALI of the immunoliposomes was shown to be superior to conventional dexamethasone administration. These results demonstrate the potential of actively targeted glucocorticoid therapy in the treatment of lung disease in clinical practice.

  20. Features of influence of sports activities on the identity of students

    Directory of Open Access Journals (Sweden)

    Sutula Vasilij

    2017-02-01

    Full Text Available Purpose: the definition of features of influence of sports activities on the identity of sportsmen. Material & Methods: the special surveys of students and teachers of KhSAPC, and also students, who train in sports club "Politekhnik", and the students who are engaged in sports sections NLA were conducted for the solution of purposes. Results: the most important qualities of the personality which sports activities influence are: formation of "confidence", "emotional stability", and "orientation to achievement" at sportsmen. According to most of the interviewed sportsmen and experts, the authority of the coach is not significant factor which influences the identity of sportsmen. Conclusions: it is established as a result of the conducted researches that sports activities most of all influence the formation of confidence, emotional stability and orientation to achievement at sportsmen. Results of the research demonstrate also that the identity of the sportsman is most influenced by the competitive relationship which develops in the course of competitive activity. Results of the research also indicate disturbing tendency which is shown that most of sportsmen connect the end of their sports career with injuries.

  1. Experimentação e uso regular de bebidas alcoólicas, cigarros e outras substâncias psicoativas/SPA na adolescência Experimentation and regular use of alcoholic beverages, cigarettes and other Psychoactive Substances (PAS during adolescence

    Directory of Open Access Journals (Sweden)

    Maria Conceição O. Costa

    2007-10-01

    Full Text Available OBJETIVO: analisar o uso de bebidas alcoólicas, cigarros, outras substâncias psicoativas - SPA e fatores de risco entre adolescentes das escolas de um município com 500 mil/hab., Bahia/Brasil. MÉTODO: estudo transversal, com amostra aleatória, estratificada por conglomerado com adolescentes de 14 a 19 anos, totalizando 10 escolas públicas e 1.409 alunos de Feira de Santana. O instrumento auto-aplicável foi elaborado segundo a OMS e outros estudos nacionais adequados à faixa adolescente, com rigoroso procedimento, garantindo anonimato e sigilo. RESULTADOS: 86,5% dos adolescentes consideravam-se bem informados sobre SPA, a maioria por TV, rádio e escola; 57,0% relataram uso de bebidas alcoólicas, principalmente cervejas e vinhos; 23,3% usavam cigarros e 5,2% outras SPA (cânabis, solventes e cocaína; 29,3% usavam bebidas uma a três vezes/mês e 13% todo final de semana. Na faixa de 10 a 14 anos, 47% experimentaram bebidas e 16,7% outras SPA. A razão de prevalência (RP mostrou consumo de bebidas, cigarros e outras SPA significantemente maiores na faixa 17 a 19 anos e sexo masculino. A curiosidade foi a principal motivação; na companhia de amigos e pais; festas e casas de colegas. CONCLUSÕES: A Necessidade de institucionalização de atividades adequadas nas escolas à prevenção do uso das SPA entre jovens.OBJECTIVE: To analyze the use of alcoholic beverages, cigarettes, other psychoactive substances - PAS , among adolescents of public schools of Feira de Santana, Bahia/Brazil. METHOD: Cross sectional study with random samples, stratified in terms of conglomerate units (schools and students. The sample of the study totalled 1,409 adolescents between 14 and 19 years old from 10 public schools; 30% of the total of schools of the municipality with 500,000/inhabitants. The representation of schools and students was respected. The self-report instrument was elaborated according to OMS recommendations and as used in others studies1

  2. Bone mineral density, muscle strength and physical activity. A population-based study of 332 subjects aged 15-42 years.

    Science.gov (United States)

    Düppe, H; Gärdsell, P; Johnell, O; Nilsson, B E; Ringsberg, K

    1997-04-01

    The aim of this population-based study was to find out whether differences in levels of physical activity have an influence on bone mass quantity and whether quadriceps muscle strength is a reliable determinant of bone mass. Included were 175 men and 157 women, aged 15-42 years. Bone mineral density (BMD) was measured at various sites by dual X-ray absorptiometry (DXA) and single photon absorptiometry (SPA). Muscle strength was assessed using an isokinetic muscle force meter. A questionnaire was used to estimate the level of physical activity. We found a positive correlation between physical activity and BMD for boys at the distal forearm and for girls at the trochanter (age group 15-16 years). Active men (age group 21-42 years) had up to 9% higher BMD levels at the hip than those who were less active. Quadriceps muscle torque was not an independent predictor of BMD. Our data suggest that a higher level of physical activity-within the limits of a "normal life style"-may have a positive effect on BMD in the proximal femur of young adults, which in turn may lessen the subsequent risk of fracture.

  3. Influence Of Dilution Factor For Activity Measurement Of 60CO

    International Nuclear Information System (INIS)

    Hermawan-Candra; Nazaroh; Ermi-Juita

    2003-01-01

    Influence of dilution factor for activity measurement of 60 Co has been studied. The aim of this research is to determine influence between activity measurement result of 60 Co before and after diluted. Measurement were done by using ionization chamber detectors system and gamma spectrometry system with NaI(TI) detector. Discrepancy within three ionization chambers measurements were 0.2% - 2.1% and NaI(Tl) were 3.5% - 6%. (author)

  4. Association between Hypothesized Parental Influences and Preschool Children's Physical Activity Behavior

    Science.gov (United States)

    Loprinzi, Paul D.; Schary, David P.; Beets, Michael W.; Leary, Janie; Cardinal, Bradley J.

    2013-01-01

    Background: To date, most research investigating the influence of parents on children"s physical activity behavior has been conducted among school-aged children. As a result, we have a limited understanding of the mechanisms through which parents can influence their young children's physical activity behavior. The purpose of this study was to…

  5. Social Physique Anxiety and Pressure to Be Thin in Adolescent Ballet Dancers, Rhythmic Gymnastics and Swimming Athletes

    Science.gov (United States)

    Kosmidou, Evdoxia; Giannitsopoulou, Evgenia; Moysidou, Dimitra

    2017-01-01

    Participation in sports may influence negative body image and Social Physique Anxiety (SPA) as there is pressure by significant others to have a certain body image. The aim of the present study was to examine possible differences in SPA and perceived pressure to be thin between female preadolescent and adolescent ballet dancers, rhythmic…

  6. Environmental influences on food choice, physical activity and energy balance.

    Science.gov (United States)

    Popkin, Barry M; Duffey, Kiyah; Gordon-Larsen, Penny

    2005-12-15

    In this paper, the environment is defined as the macro- and community-level factors, including physical, legal and policy factors, that influence household and individual decisions. Thus, environment is conceived as the external context in which household and individual decisions are made. This paper reviews the literature on the ways the environment affects diet, physical activity, and obesity. Other key environmental factors discussed include economic, legal, and policy factors. Behind the major changes in diet and physical activity in the US and globally lie large shifts in food production, processing, and distribution systems as well as food shopping and eating options, resulting in the increase in availability of energy-dense foods. Similarly, the ways we move at home, work, leisure, and travel have shifted markedly, resulting in substantial reductions in energy expenditure. Many small area studies have linked environmental shifts with diet and activity changes. This paper begins with a review of environmental influences on diet and physical activity, and includes the discussion of two case studies on environmental influences on physical activity in a nationally representative sample of US adolescents. The case studies illustrate the important role of physical activity resources and the inequitable distribution of such activity-related facilities and resources, with high minority, low educated populations at strong disadvantage. Further, the research shows a significant association of such facilities with individual-level health behavior. The inequity in environmental supports for physical activity may underlie health disparities in the US population.

  7. Physical activity in spondyloarthritis: a systematic review

    LENUS (Irish Health Repository)

    O’Dwyer, Tom

    2014-10-01

    Physical activity (PA) is associated with numerous health-related benefits among adults with chronic diseases and the general population. As the benefits are dose-dependent, this review aims to establish the PA levels of adults with spondyloarthritis and to compare these to the general population. Electronic databases (Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE\\/PubMed, PEDro, AMED, CINAHL) were systematically searched from inception to May 2014 using medical subject headings and keywords. This was supplemented by searching conference abstracts and hand-searching reference lists of included studies. Eligible studies were randomized controlled trials and observational studies of adults with SpA in which free-living PA or energy expenditure levels were measured. Subjects less than 18 years or with juvenile-onset SpA were excluded. Outcomes included objective and self-report measurements. Two reviewers independently screened studies for inclusion and assessed methodological quality using the Cochrane risk of bias tool and the RTI item bank. From the 2,431 records reviewed, nine studies involving 2,972 participants were included. This review focused on qualitative synthesis. Meta-analyses were not undertaken due to differences in study design, measurement tools, and participant characteristics. This heterogeneity, coupled with the risk of bias inherent in the included observational studies, limits the generalizability of findings. Objective measurements suggest PA levels may be lower among adults with spondyloarthritis than in healthy population controls. Self-reported PA and self-reported rates of adherence to PA recommendations varied largely across studies; higher disease activity was associated with lower self-reported PA levels. Physical activity levels may be lower in adults with axial spondyloarthritis, with higher disease activity associated with lower PA levels.

  8. An Improved MLVF Method and Its Comparison with Traditional MLVF, spa Typing, MLST/SCCmec and PFGE for the Typing of Methicillin-Resistant Staphylococcus aureus

    Science.gov (United States)

    Du, Xue-Fei; Xiao, Meng; Liang, Hong-Yan; Sun, Zhe; Jiang, Yue-Hong; Chen, Guo-Yu; Meng, Xiao-Yu; Zou, Gui-Ling; Zhang, Li; Liu, Ya-Li; Zhang, Hui; Sun, Hong-Li; Jiang, Xiao-Feng; Xu, Ying-Chun

    2014-01-01

    Methicillin-resistant Staphylococcus aureus (MRSA) has become an important nosocomial pathogen, causing considerable morbidity and mortality. During the last 20 years, a variety of genotyping methods have been introduced for screening the prevalence of MRSA. In this study, we developed and evaluated an improved approach capillary gel electrophoresis based multilocus variable-number tandem-repeat fingerprinting (CGE/MLVF) for rapid MRSA typing. A total of 42 well-characterized strains and 116 non-repetitive clinical MRSA isolates collected from six hospitals in northeast China between 2009 and 2010 were tested. The results obtained by CGE/MLVF against clinical isolates were compared with traditional MLVF, spa typing, Multilocus sequence typing/staphylococcal cassette chromosome mec (MLST/SCCmec) and pulse field gel electrophoresis (PFGE). The discriminatory power estimated by Simpson’s index of diversity was 0.855 (28 types), 0.855 (28 patterns), 0.623 (11 types), 0.517 (8 types) and 0.854 (28 patterns) for CGE/MLVF, traditional MLVF, spa typing, MLST/SCCmec and PFGE, respectively. All methods tested showed a satisfied concordance in clonal complex level calculated by adjusted Rand’s coefficient. CGE/MLVF showed better reproducibility and accuracy than traditional MLVF and PFGE methods. In addition, the CGE/MLVF has potential to produce portable results. In conclusion, CGE/MLVF is a rapid and easy to use MRSA typing method with lower cost, good reproducibility and high discriminatory power for monitoring the outbreak and clonal spread of MRSA isolates. PMID:24406728

  9. Influence of Aging on Plasma Renin Activity

    International Nuclear Information System (INIS)

    Cho, K. W.; Kim, S. H.; Kang, S. K.; Choi, H. Y.

    1982-01-01

    Influence of aging on plasma renin activity was evaluated in healthy normotensive subjects(age range 21-63 years, 413 males) devoid of cardiorenal or endocrinological problems. The age-related decrease of plasma renin activity in the subjects between 21-28 years group and 36-42 years group was slight, but over the 43 years groups was significantly different. The age-related suppression of plasma renin activity was much more smooth and continuous all over the age ranges evaluated. The sexual difference in plasma renin activity was noticed between the subjects of 22 years old group (34 males) and 19 years group (34 females) (p<0.003). The data suggest that the age-related suppression of plasma renin activity appeared in healthy normotensive subjects should be considered in the case of evaluation of low renin essential hypertension.

  10. Verification of the validity of the short-pulse approximation for one-dimensional Rydberg atoms

    International Nuclear Information System (INIS)

    Kopyciuk, T; Grajek, M

    2011-01-01

    In this paper, we investigate the short-pulse approximation (SPA) for one-dimensional Rydberg atoms. We analyse the limits that SPA has to fulfil in order to be applicable. These concern the shape, the duration and the displacement caused by the pulse. The correctness of SPA is tested by comparing the results obtained using SPA with a numerical solution of the set of time-dependent Schroedinger equations. We show that the limit for the displacement caused by the pulse is of greatest importance. Violation of the limit for the duration of the pulse is shown to lead to concurrent violation of the limit for the displacement. We also show that the shape of the pulse has no influence on the created wave packet.

  11. The Results of the Development of Balneal Care Provision and the State of the Czech Spa Industry in Connection with the Changes in Legislation

    Directory of Open Access Journals (Sweden)

    Vavrečková Eva

    2017-06-01

    Full Text Available The paper focuses on the development of balneal care provision and its current state in the Czech spa industry in connection with the changes in legislation. In particular, the period of 2000–2015 is specified, including the survey of positive and negative changes resulting from the changes in legal norms regulating the balneal care provision. Special attention is paid to two turning points in the balneal care provision: the turn of 2012 and 2013 and the turn of 2014 and 2015, which were significantly affected by the changing legislation.

  12. Measurements of radon activity concentrations in air at Niska spa

    International Nuclear Information System (INIS)

    Adrovic, F.; Vuckovic, B.; Ninkovic, M.

    2004-01-01

    Radon activity concentrations in air were measured in the recreational-tourist center of Niska Banja. Alpha Guard PQ 2000/ MC50 instrumentation (Genitron instruments, Frankfurt) was used. The observed indoor radon concentrations in the air of the Radon Hotel pool lay within the range of 0.980-1.908 kBq/m 3 and were directly dependent on the exhalation of radon from thermomineral waters. Radon concentrations were also measured outdoors, at locations for capping thermomineral water, as well as at locations for draining used water from the Radon Hotel pool. Outdoor radon concentrations as high as over 500 Bq/m 3 were observed. Gamma dose rates were measured in parallel and found to lie within the range of 72-420 nSv/h. The gamma doses correlated well with the observed radon levels. The largest gamma dose rates in air were measured in the pool of Radon Hotel and at the site where this thermomineral water is being capped

  13. Influence of friends on children's physical activity: a review.

    Science.gov (United States)

    Maturo, Claire C; Cunningham, Solveig A

    2013-07-01

    We examined evidence for friendship influences on children's physical activity (PA) through systematic searches of online databases in May 2012. We identified 106 studies (25 qualitative) published in English since 2000 that analyzed indicators of friendship influences (e.g., communication about PA, friends' PA, and PA with friends) among persons younger than 19 years. Children's PA was positively associated with encouragement from friends (43 of 55 studies indicating a positive relationship), friends' own PA (30/35), and engagement with friends in PA (9/10). These findings are consistent with friends influencing PA, but most studies did not isolate influence from other factors that could explain similarity. Understanding friendship influences in childhood can facilitate the promotion of lifelong healthy habits. PA with friends should be considered in health promotion programs.

  14. Parental Influence on Physical Activity of Children with Disabilities

    Science.gov (United States)

    Siebert, Erin A.; Hamm, Jessica; Yun, Joonkoo

    2017-01-01

    The purpose of this study was to identify parental influences on physical activity behaviours of children with disabilities. One hundred and forty-eight parents of children with disabilities responded to a survey about factors related to parent and child physical activity, parental support and belief in their child's abilities regarding physical…

  15. SCCmec type IX element in Methicillin resistant Staphylococcus aureus spa-type t337 (CC9 isolated from pigs and pork in Thailand

    Directory of Open Access Journals (Sweden)

    Martin eVestergaard

    2012-03-01

    Full Text Available Methicillin resistant Staphylococcus aureus (MRSA have emerged among livestock in several countries. In this study, we describe the results of a screening performed in pigs and raw pork samples in Thailand. Ten pork samples and 15 nasal swabs from pigs were collected from two markets and one pig farm in the Samuth Songkhram province in Thailand. MRSA were isolated using selective isolation procedures and confirmed by mecA PCR. The MRSA were characterized by antimicrobial susceptibility testing, PFGE, spa typing, SCCmec typing, and MLST. Resistance and virulence markers were screened using a microarray. Five of the pork samples and six pig nasal swabs were positive for MRSA. All 11 isolates belonged to spa type t337 and CC9 but showed diversity in antimicrobial resistance patterns and PFGE profiles. All isolates harbored SCCmec IX and were resistant to seven out of 14 tested antimicrobials; additional resistances were found in the pork isolates. Microarray analysis identified blaZ, aac-aphD, vga(A, tetM, and a tet efflux marker, in all strains and additionally ermB and aadD, cat and fex(A in the pork isolates. None of the isolates were found PVL-positive, but enterotoxins were identified in all isolates. This is, to our knowledge, the first description of MRSA in livestock and food products in Thailand and also the first observation of MRSA CC9 associated with SCCmec IX. This study indicates a likely widespread distribution of MRSA in pig and pork in Thailand and further investigation on the prevalence and importance of livestock associated MRSA in Thailand is needed.

  16. Applying the global RCP-SSP-SPA scenario framework at sub-national scale: A multi-scale and participatory scenario approach.

    Science.gov (United States)

    Kebede, Abiy S; Nicholls, Robert J; Allan, Andrew; Arto, Iñaki; Cazcarro, Ignacio; Fernandes, Jose A; Hill, Chris T; Hutton, Craig W; Kay, Susan; Lázár, Attila N; Macadam, Ian; Palmer, Matthew; Suckall, Natalie; Tompkins, Emma L; Vincent, Katharine; Whitehead, Paul W

    2018-09-01

    To better anticipate potential impacts of climate change, diverse information about the future is required, including climate, society and economy, and adaptation and mitigation. To address this need, a global RCP (Representative Concentration Pathways), SSP (Shared Socio-economic Pathways), and SPA (Shared climate Policy Assumptions) (RCP-SSP-SPA) scenario framework has been developed by the Intergovernmental Panel on Climate Change Fifth Assessment Report (IPCC-AR5). Application of this full global framework at sub-national scales introduces two key challenges: added complexity in capturing the multiple dimensions of change, and issues of scale. Perhaps for this reason, there are few such applications of this new framework. Here, we present an integrated multi-scale hybrid scenario approach that combines both expert-based and participatory methods. The framework has been developed and applied within the DECCMA 1 project with the purpose of exploring migration and adaptation in three deltas across West Africa and South Asia: (i) the Volta delta (Ghana), (ii) the Mahanadi delta (India), and (iii) the Ganges-Brahmaputra-Meghna (GBM) delta (Bangladesh/India). Using a climate scenario that encompasses a wide range of impacts (RCP8.5) combined with three SSP-based socio-economic scenarios (SSP2, SSP3, SSP5), we generate highly divergent and challenging scenario contexts across multiple scales against which robustness of the human and natural systems within the deltas are tested. In addition, we consider four distinct adaptation policy trajectories: Minimum intervention, Economic capacity expansion, System efficiency enhancement, and System restructuring, which describe alternative future bundles of adaptation actions/measures under different socio-economic trajectories. The paper highlights the importance of multi-scale (combined top-down and bottom-up) and participatory (joint expert-stakeholder) scenario methods for addressing uncertainty in adaptation decision

  17. Occult spondyloarthritis in inflammatory bowel disease.

    Science.gov (United States)

    Bandinelli, Francesca; Manetti, Mirko; Ibba-Manneschi, Lidia

    2016-02-01

    Spondyloarthritis (SpA) is a frequent extra-intestinal manifestation in patients with inflammatory bowel disease (IBD), although its real diffusion is commonly considered underestimated. Abnormalities in the microbioma and genetic predisposition have been implicated in the link between bowel and joint inflammation. Otherwise, up to date, pathogenetic mechanisms are still largely unknown and the exact influence of the bowel activity on rheumatic manifestations is not clearly explained. Due to evidence-based results of clinical studies, the interest on clinically asymptomatic SpA in IBD patients increased in the last few years. Actually, occult enthesitis and sacroiliitis are discovered in high percentages of IBD patients by different imaging techniques, mainly enthesis ultrasound (US) and sacroiliac joint X-ray examinations. Several diagnostic approaches and biomarkers have been proposed in an attempt to correctly classify and diagnose clinically occult joint manifestations and to define clusters of risk for patient screening, although definitive results are still lacking. The correct recognition of occult SpA in IBD requires an integrated multidisciplinary approach in order to identify common diagnostic and therapeutic strategies. The use of inexpensive and rapid imaging techniques, such as US and X-ray, should be routinely included in daily clinical practice and trials to correctly evaluate occult SpA, thus preventing future disability and worsening of quality of life in IBD patients.

  18. The detailed analysis of natural radionuclides dissolved in spa waters of the Kłodzko Valley, Sudety Mountains, Poland

    International Nuclear Information System (INIS)

    Walencik-Łata, A.; Kozłowska, B.; Dorda, J.; Przylibski, T.A.

    2016-01-01

    A survey was conducted to measure natural radioactivity in spa waters from the Kłodzko Valley. The main goal of this study was to determine the activity concentration of uranium, radium and radon isotopes in the investigated groundwaters. Samples were collected several times from 35 water intakes from 5 spas and 2 mineral water bottling plants. The authors examined whether the increased gamma radiation background, as well as the elevated values of radium and uranium content in reservoir rocks, have a significant impact on the natural radioactivity of these waters. The second objective of this research was to provide information about geochemistry of U, Ra, Rn radionuclides and the radiological and chemical risks incurred by ingestion of isotopes with drinking water. On the basis of results obtained, it is feasible to assess the health hazard posed by ingestion of natural radioactivity with drinking waters. Moreover, the data yielded by this research may be helpful in the process of verification of the application of these waters in balneotherapy. In addition, annual effective radiation doses resulting from the isotopes consumption were calculated on the basis of the evaluated activity concentrations. In dose assessment for uranium and radium isotopes, the authors provided values for different human age groups. The obtained uranium content in the investigated waters was compared with the currently valid regulations concerning the quality of drinking water. Based on the activity concentrations data, the activity isotopic ratios 234 U/ 238 U, 226 Ra/ 238 U, 222 Rn/ 238 U, 222 Rn/ 226 Ra and the correlations between radionuclides content were then examined. In brief, it may be concluded on the basis of the obtained results that radon solubility is inversely proportional to radium and uranium dissolution in environmental water circulation. The presented study allows conclusions to be drawn on the radionuclide circulation among different environmental biota: from

  19. The fast trigger electronics of the lead/scintillating fiber calorimeter SpaCal of the H1 experiment at HERA: accomplishment, results of test beam measurements at CERN and first results at HERA

    International Nuclear Information System (INIS)

    Spielmann, Stephan

    1996-01-01

    The studies presented in this thesis cover parts of the project to improve the H1 detector at the electron-proton collider HERA. The main goal of this improvement was to build a lead/scintillating fiber calorimeter (SpaCal) and its associate trigger and read-out electronics. The description and the analysis of measurements with a calorimeter prototype and its electronics are presented with respect to the performance requirements for the project. This measurement realized at a CERN test beam facility have shown that an on-line selection of physics events out of background events can be achieved with a time-of-flight measurement. The efficiency of the trigger is higher than 99 percent independent of the particles' impact points. The feasibility of electron/pion separation on the one percent level is also shown. In 1995 the SpaCal calorimeter was integrated in the H1 detector. A detailed description of its associate electronics is given and the results on the trigger's performance for the first year of data taking are presented. (author) [fr

  20. Spa therapy (balneotherapy) relieves mental stress, sleep disorder, and general health problems in sub-healthy people

    Science.gov (United States)

    Yang, Bei; Qin, Qi-zhong; Han, Ling-li; Lin, Jing; Chen, Yu

    2018-02-01

    To investigate the relieving effects of hot spring balneotherapy on mental stress, sleep disorder, general health problems, and women's health problems in sub-healthy people, we recruited 500 volunteers in sub-health in Chongqing, and 362 volunteers completed the project, including 223 in the intervention group and 139 in the control group. The intervention group underwent hot spring balneotherapy for 5 months, while the control group did not. The two groups took questionnaire investigation (general data, mental stress, emotional status, sleep quality, general health problems, as well as some women's health problems) and physical examination (height, weight, waist circumference, blood pressure, blood lipid, blood sugar) 5 months before and after the intervention, respectively. After intervention, sleep disorder (difficulty in falling asleep ( P = 0.017); dreaminess, nightmare suffering, and restless sleep ( P = 0.013); easy awakening ( P = 0.003) and difficulty in falling into sleep again after awakening( P = 0.016); and mental stress ( P = 0.031) and problems of general health (head pain ( P = 0.026), joint pain( P = 0.009), leg or foot cramps ( P = 0.001), blurred vision ( P = 0.009)) were relieved significantly in the intervention group, as compared with the control group. While other indicators (fatigue, eye tiredness, limb numbness, constipation, skin allergy) and women's health problems (breast distending pain; dysmenorrhea, irregular menstruation) were relieved significantly in the self-comparison of the intervention group before and after intervention ( P 0.05). All indications (except bad mood, low mood, and worry or irritability) in the intervention group significantly improved, with effect size from 0.096 to 1.302. Multiple logistic regression analysis showed that the frequency, length, and location of balneotherapy in the intervention group were the factors influencing emotion, sleep, and health condition ( P Physical examination found that waist

  1. Selected aspects of radon presence in medicinal waters in Swieradow Spa; Wybrane aspekty obecnosci radonu w wodach leczniczych Swieradowa Zdroju

    Energy Technology Data Exchange (ETDEWEB)

    Przybilski, T.A. [Politechnika Wroclawska, Wroclaw (Poland)

    1996-12-31

    In the paper results of measurement of radium content in the rocks of the neighbourhood of Swieradow Spa were used to calculate emanating coefficient of rocks. The coefficient was next used to estimate the volume of rocks supplying the intakes with radon; in this estimation radioactive equilibrium between radium and radon in the rocks was assumed. The results obtained lead to the conclusion that such equilibrium is absent and allow estimating its coefficient as 10{sup -6}. It was also proposed to use track detectors to the continuous monitoring of radon concentrations in the ground waters, which was shown on the example of comparison of relative radon concentrations in individual wells of medicinal water intakes. (author). 14 refs, 1 tab.

  2. How an active-learning class influences physics self-efficacy in pre-service teachers

    Science.gov (United States)

    Gaffney, Jon D. H.; Housley Gaffney, Amy L.; Usher, Ellen L.; Mamaril, Natasha A.

    2013-01-01

    Education majors in an inquiry-based physics content course were asked to reflect on the ways the course affected their self-efficacy for completing physics tasks, such as creating a circuit. Responses were coded according to the contributor of the influence and whether that influence was positive or negative. The group learning structure, hands-on activities in the class, and the constructed repertoire of science knowledge, processes, and activities, were all reported to be positive influences on self-efficacy, whereas the influence of the instructor was mixed. Overall, students' responses indicated both a desire for more guidance and lecture and an appreciation for their ability to construct their own understanding through the class activities.

  3. Influence of Friends on Children’s Physical Activity: A Review

    OpenAIRE

    Maturo, Claire C.; Cunningham, Solveig A.

    2013-01-01

    We examined evidence for friendship influences on children’s physical activity (PA) through systematic searches of online databases in May 2012. We identified 106 studies (25 qualitative) published in English since 2000 that analyzed indicators of friendship influences (e.g., communication about PA, friends’ PA, and PA with friends) among persons younger than 19 years.

  4. Tracing How Normative Messages May Influence Physical Activity Intention.

    Science.gov (United States)

    van Bavel, René; Esposito, Gabriele; Baranowski, Tom; Duch-Brown, Néstor

    2017-04-01

    Normative messages have been shown to increase intention to do physical activity. We traced how "positive" and "negative" normative messages influenced physical activity intention by comparing constructs of the model of goal-directed behavior with descriptive norms (MGDB + DNs) across control and treatment groups in an experiment. For this purpose, 16-24-year-old respondents (n = 1,200) in Bulgaria, Croatia, and Romania were asked about their age, sex, and levels of physical activity before being exposed to positive and negative normative messages and completing a questionnaire with MGDB + DNs scales. Different MGDB + DNs constructs were influenced by the normative messages: compared with the control, the negative message group showed stronger attitudes (p = .003) and the positive message group showed higher positive anticipated emotions (p = .005). The positive message's effect is consistent with the literature on conformity to social norms. The negative message's effect lends itself to interpretations based on social identity and deviance regulation theories.

  5. Parental Influence on Young Children's Physical Activity

    Directory of Open Access Journals (Sweden)

    Cheryl A. Zecevic

    2010-01-01

    Full Text Available Parents influence on their young children's physical activity (PA behaviours was examined in a sample of 102 preschool-aged children (54 boys. Questionnaires regarding family sociodemographics and physical activity habits were completed. Results showed that children who received greater parental support for activity (B=.78, P<.10 and had parents who rated PA as highly enjoyable (B=.69, P<.05 were significantly more likely to engage in one hour or more of daily PA. Being an older child (B=−.08, P<.01, having older parents (B=−.26, P<.01, and watching more than one hour of television/videos per day (B=1.55, P<.01 reduced the likelihood that a child would be rated as highly active. Children who received greater parental support for PA were 6.3 times more likely to be highly active than inactive (B=1.44, P<.05. Thus, parents can promote PA among their preschoolers, not only by limiting TV time but also by being highly supportive of their children's active pursuits.

  6. Self-Efficacy Manipulation Influences Physical Activity Enjoyment in Chinese Adolescents.

    Science.gov (United States)

    Hu, Liang; Cheng, Shoubin; Lu, Jiaying; Zhu, Lele; Chen, Ling

    2016-02-01

    In this study, we examined the effect of the manipulation of exercise self-efficacy on the enjoyment of physical activity in a sample of 44 Chinese adolescents (age = 14.27 ± .87 y), including 22 boys and 22 girls. The participants were randomized into a low-efficacy or high-efficacy condition, and their self-efficacy beliefs for engaging in moderate-intensity physical activity were manipulated by providing false feedback after a submaximal exercise test. The participants' self-efficacy was measured and compared before and after the exercise test and the participants' enjoyment of physical activity was assessed after the exercise test. It was found that exercise self-efficacy was successfully manipulated in the expected direction in both conditions, which significantly influenced the participants' enjoyment of physical activity. After the exercise test, the participants in the low-efficacy condition reported lower enjoyment scores relative to the high-efficacy participants. These results suggest that self-efficacy may have an important influence on the enjoyment of physical activity among Chinese adolescents. We recommend that physical activity promotion programs should be tailored to enhance adolescents' self-efficacy beliefs and enjoyment of the experience of physical activity.

  7. Effect of Hofmeister series salts on Absorptivity of aqueous solutions on Sodium polyacrylate

    Science.gov (United States)

    Korrapati, Swathi; Pullela, Phani Kumar; Vijayalakshmi, U.

    2017-11-01

    Sodium polyacrylate (SPA) is a popular super absorbent commonly used in children diapers, sanitary pads, adult diapers etc. The use of SPA is in force from past 30 years and the newer applications like as food preservant are evolving. SPA is recently discovered by our group for improvement of sensitivity of colorimetric agents. Though the discovery of improvement in sensitivity is phenomenal, the mechanism still remains a puzzle. A typical assay reagent contains colorimetric/fluorescent reagents, buffers, salts, stabilizers etc. These chemicals are known to influence the water absorptivity of SPA. If we were to perform chemical/biochemical assays on SPA absorbed reagents effect of salts and other excipients on colorimetric/fluorescence compounds absorbed on SPA is very important. The hofmeister series are standard for studying effect of salts on permeability, stability, aggregation, fluorescence quenching etc. We recently studied affect of urea, sodium chloride, ammonium sulfate, guanidine thiocayanate on fluorescence characteristics of fluorescence compounds and noted that except urea all other reagents have resulted in fluorescence quenching and urea had an opposite effect and increased the fluorescence intensity. This result was attributed to the different water structure around fluorescent in urea solution versus other chaotropic agents.

  8. Stable isotopic and mineralogical studies of hydrothermal alteration at Arima Spa, Southwest Japan

    International Nuclear Information System (INIS)

    Masuda, Harue; Osaka City Univ.; Sakai, Hitoshi; Chiba, Hitoshi; Matsuhisa, Yukihiro; Nakamura, Takeshi

    1986-01-01

    The waters of Arima Spa, Southwest Japan, have high salinity (Cl = 54 g/kg) and high isotopic ratios (deltaD = -32, and delta 18 O = +10 per mille), and issue from shallow wells drilled into altered rhyolitic pyroclastic rocks of Cretaceous age. Alteration of the host rocks occurred in two stages. The earlier regional alteration stage is characterized by the presence of 2M- and 1M-type muscovite, albite, chlorite, calcite and epidote, whereas muscovite and Fe-chlorite formation at the expense of partly albitized plagioclase and altered biotite or hornblende occurred in the following hydrothermal stage. Pyrite, sphalerite, galena and siderite are present in the central part of the hydrothermal alteration zone. Oxygen and hydrogen isotopic ratios of secondary muscovite show that regional alteration proceeded under the meteoric circulation, and that the hydrothermal fluid for the second stage had chemical and stable isotopic characteristics of non-meteoric origin similar to the present-day Arima brine. The oxygen and to a lesser extent the hydrogen isotopic ratios of the muscovite rapidly decrease with increasing distance from the central zone of hydrothermal alteration. The isotopic variation is best interpreted as reflecting rapidly decreasing fluid/rock ratios with increasing distance of fluid penetration from the narrow hydrothermal alteration zone into the surrounding area. The results are discussed. (author)

  9. The influence of human activity in the Arctic on climate and climate impacts

    Energy Technology Data Exchange (ETDEWEB)

    Huntington, H.P. [23834 The Clearing Dr., Eagle River, AK 99577 (United States); Boyle, M. [Institute for Resources, Environment and Sustainability, University of British Columbia, 2202 Main Mall, Vancouver, BC, V6S 1K4 (Canada); Flowers, G.E. [Department of Earth Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6 (Canada); Weatherly, J.W. [Snow and Ice Division, Cold Regions Research and Engineering Laboratory, 72 Lyme Road, Hanover, NH 03755 (United States); Hamilton, L.C. [Department of Sociology, University of New Hampshire, 20 College Road, Durham, NH 03824 (United States); Hinzman, L. [Water and Environment Research Center, University of Alaska Fairbanks, P.O. Box 755860, Fairbanks, AK 99775 (United States); Gerlach, C. [Department of Anthropology, University of Alaska Fairbanks, P.O. Box 757720, Fairbanks, AK 99775 (United States); Zulueta, R. [Department of Biology, Global Change Research Group, San Diego State University, 5500 Campanile Drive, PS-240, San Diego, CA 92182 (United States); Nicolson, C. [Department of Natural Resources Conservation, University of Massachusetts, 160 Holdsworth Way, Amherst, MA , 01003 (United States); Overpeck, J. [Institute for the Study of Planet Earth, University of Arizona, 715 North Park Avenue, 2nd Floor, Tucson, AZ, 85721 (United States)

    2007-05-15

    Human activities in the Arctic are often mentioned as recipients of climate-change impacts. In this paper we consider the more complicated but more likely possibility that human activities themselves can interact with climate or environmental change in ways that either mitigate or exacerbate the human impacts. Although human activities in the Arctic are generally assumed to be modest, our analysis suggests that those activities may have larger influences on the arctic system than previously thought. Moreover, human influences could increase substantially in the near future. First, we illustrate how past human activities in the Arctic have combined with climatic variations to alter biophysical systems upon which fisheries and livestock depend. Second, we describe how current and future human activities could precipitate or affect the timing of major transitions in the arctic system. Past and future analyses both point to ways in which human activities in the Arctic can substantially influence the trajectory of arctic system change.

  10. Kinematics, dynamics and structural analyses of a semi-passive mechanical arm; Analise cinematica, dinamica e estrutural de um manipulador semi-passivo

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Claudio Violante [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil); Romano, Vitor Ferreira [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Escola Politecnica

    2008-07-01

    This work presents the dynamics and kinematics modeling, and the structural analysis (including modal analysis) of a gantry type Semi-Passive mechanical Arm (SPA). The kinematics analysis of the SPA is referred in the Joints Space Coordinates. The Denavit-Hartenberg (D-H) parameterization method is used in the manipulator kinematics model. The dynamics analysis is also referred in the Joints Space, and done by means of Lagrange Equations. To develop the dynamic equations it were considered the joints friction and the external loads related to marine currents and the AUV/SPA interaction. The dynamics analysis it was done in two SPA configurations: all joints with activated brakes (locked) and all joints with not activated brakes. A commercial FEM program, ANSYS{sup R} 5.5.1, was used to calculate the structural deformations and tensions, and these results were used to define the final structure configuration. This program has a Static Analysis Package which permits to determine the displacements, stresses, strains and forces in structures caused by external loads. In order to evaluate the SPA structural stiffness it was done the modal analysis and the determination of five SPA vibration modes and natural frequencies. (author)

  11. Teaching Grammar and Testing Grammar in the English Primary School: The Impact on Teachers and Their Teaching of the Grammar Element of the Statutory Test in Spelling, Punctuation and Grammar (SPaG)

    Science.gov (United States)

    Safford, Kimberly

    2016-01-01

    The research examined the impact on teachers of the grammar element of a new statutory test in Spelling, Punctuation and Grammar (SPaG) in primary schools in England. The research aimed to evaluate the nature and the extent of changes to the teaching of grammar and to wider literacy teaching since the introduction of the test in 2013. The research…

  12. Cellular uptake and processing of surfactant lipids and apoprotein SP-A by rat lung

    International Nuclear Information System (INIS)

    Young, S.L.; Wright, J.R.; Clements, J.A.

    1989-01-01

    The intracellular pathways and the kinetics of metabolism of surfactant apoprotein and lipid, which may be recycled from the alveolar space, are largely unknown. We used a lipid-apoprotein complex made from liposomes of pure lipids in a ratio found in mammalian pulmonary surfactant plus surfactant apoprotein (SP-A, Mr = 26,000-36,000) to test some possible relationships in the recycling of these major surfactant components between intrapulmonary compartments. After intratracheal instillation of 80 microliters of an apoprotein-liposome mixture with separate radiolabels in the lipid and the apoprotein, rats were killed at times from 8 min to 4 h later. The lungs were lavaged with saline, and subcellular fractions were isolated on discontinuous sucrose density gradients. Both the [ 14 C]lipid radiolabel and the 125 I-apoprotein radiolabel demonstrated a time-dependent increase in radioactivity recovered in a lamellar body-enriched fraction. Uptake of the radiolabels into other subcellular fractions did not exhibit a clear-cut time dependence; more of the protein than the lipid radiolabel was found in the Golgi-rich and microsomal fractions. We conclude that both the lipid and apoprotein portions of lung surfactant are taken up by lung cells and are incorporated into secretory granules of the cells

  13. Characteristics of thermal-mineral waters in Backa region (Vojvodina) and their exploitation in spa tourism

    Energy Technology Data Exchange (ETDEWEB)

    Kosic, Kristina; Pivac, Tatjana; Romelic, Jovan; Lazic, Lazar; Stojanovic, Vladimir [Faculty of Science, Department of Geography, Tourism and Hotel Management, University of Novi Sad, Trg Dositeja Obradovica 3, 21000 Novi Sad (RS)

    2011-01-15

    Hydropower, biomass, biogas, biofuels, wind power, solar energy and geothermal energy are the major resources to provide Backa region with most of its. Backa extends between 45 16' and 46 22' of the northern latitude and 18 36' and 20 37' of the eastern longitude. It occupies the north-eastern part of Vojvodina, i.e. the most north-western part of the Republic of Serbia. That is historical-geographic territory bordered on the Danube on its western and eastern side, the Tisa on its eastern side and with the state border towards Hungary on the north. In this paper, the focus will be on renewable sources, specifically geothermal energy in Backa region. The paper analyzes the characteristics of thermal-mineral waters in Backa, the condition and possibilities of their exploitation in spa tourism, and in other economic branches. The tradition of thermo-mineral waters exploitation in spas and public baths is rather long. Today, this type of thermo-mineral waters exploitation in Backa is the widest spread. Permanent, i.e. continuous exploiters of thermal-mineral waters in Backa are primarily balneal-rehabilitation centres and exploiters using the water for technological purposes. (author)

  14. Magnetic resonance imaging of active sacroiliitis: Do we really need gadolinium?

    Energy Technology Data Exchange (ETDEWEB)

    Althoff, Christian E. [Department of Radiology, Charite - Universitaetsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin (Germany)], E-mail: christian.althoff@charite.de; Feist, Eugen [Department of Rheumatology and Clinical Immunology, Charite - Universitaetsmedizin Berlin, Campus Mitte (Germany); Burova, Elena [Department of Radiology, Charite - Universitaetsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin (Germany); Eshed, Iris [Department of Radiology, Chaim Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University (Israel); Bollow, Matthias [Department of Radiology, Augusta Hospital, Bochum (Germany); Hamm, Bernd; Hermann, Kay-Geert A. [Department of Radiology, Charite - Universitaetsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin (Germany)

    2009-08-15

    Introduction: Magnetic resonance imaging (MRI) of active inflammatory changes of the sacroiliac joint (SIJ) in spondyloarthritis (SpA) is performed with short tau inversion recovery (STIR) sequences and fat-saturated T1-weighted fast spin-echo (FSE) sequences after administration of gadolinium-based contrast medium (T1/Gd). The aim of the present study was to compare these two pulse sequences in terms of diagnosis, diagnostic confidence, and quantification of inflammatory changes. Materials and methods: The study included 105 patients with suspected SpA; 72 patients developed clinical SpA over time. All patients were examined with STIR and T1/Gd and each of the two sequences was analyzed separately in conjunction with unenhanced T1 FSE images. For quantitative estimation of inflammatory changes, each sacroiliac joint (SIJ) was divided into 4 quadrants (and severity per quadrant was assigned a score of 0-4, resulting in a maximum sum score of 16 per SIJ). Diagnostic confidence was assessed on a visual analogue scale ranging from 0 to 10. Results: Active sacroiliitis was diagnosed in 46 patients and ruled out in 34 using STIR, whereas findings were inconclusive in 25 patients. The corresponding numbers for T1/Gd were 47, 44, and 14. Diagnostic confidence was significantly lower for STIR (7.3 {+-} 2.6) compared with T1/Gd (8.7 {+-} 1.9) (p < 0.001). The sum scores were 2.5 ({+-}3.3) for STIR and 2.2 ({+-}3.2) for T1/Gd for the right SIJ and 2.2 ({+-}2.9) (STIR) and 1.9 ({+-}3.1) (T1/Gd) for the left SIJ. Agreement was high with intraclass correlation coefficient (ICC) values of 0.86 for the right SIJ and 0.90 for the left SIJ and positive correlation (r = 0.62 right, 0.60 left). Summary: STIR sequences alone are sufficient for establishing a reliable diagnosis and quantify the amount of inflammation in active sacroiliitis. A contrast-enhanced study is dispensable in patients with established disease or in the setting of clinical follow-up studies. However, a contrast

  15. [The effectiveness of the spa and health resort-based treatment with the application of Essentuki-type drinking mineral waters for the management of non-alcoholic fatty liver disease in the patients presenting with type 2 diabetes mellitus].

    Science.gov (United States)

    Efimenko, N V; Kaĭsinova, A S; Fedorova, T E; Botvineva, L A

    2015-01-01

    The objective of the present study was to estimate the effectiveness of the spa and health resort-based treatment of non-alcoholic fatty liver disease in 40 patients at the mean age of 48,8 ± 5.7 years suffering from type 2 diabetes mellitus. All of them received combined therapy including the application of potable Essentuki-Novaya mineral water (20 patients) or Essentuki No 4 water (20 patients). This therapeutic modality resulted in positive dynamics of clinical symptoms of the disease, the functional liver tests, and parameters of intra-hepatic hemodynamics, lipid peroxidation homeostasis, and the hormonal status. It is concluded that the spa and health resort-based treatment with the application of local drinking Essentuki-type mineral waters for the management of non-alcoholic fatty liver disease in the patients presenting with type 2 diabetes mellitus leads to the improvement of the main functions of the liver, stabilizes carbohydrate and lipid metabolism, and prevents progression of the pathological process.

  16. Social influence and adolescent health-related physical activity in structured and unstructured settings: role of channel and type.

    Science.gov (United States)

    Spink, Kevin S; Wilson, Kathleen S; Ulvick, Jocelyn

    2012-08-01

    Social influence channels (e.g., parents) and types (e.g., compliance) have each been related to physical activity independently, but little is known about how these two categories of influence may operate in combination. This study examined the relationships between various combinations of social influence and physical activity among youth across structured and unstructured settings. Adolescents (N=304), classified as high or low active, reported the social influence combinations they received for being active. Participants identified three channels and three types of influence associated with being active. For structured activity, compliance with peers and significant others predicted membership in the high active group (values of psocial influence, when examining health-related physical activity.

  17. Transmission of endemic ST22-MRSA-IV on four acute hospital wards investigated using a combination of spa, dru and pulsed-field gel electrophoresis typing.

    LENUS (Irish Health Repository)

    Creamer, E

    2012-11-01

    The transmission of meticillin-resistant Staphylococcus aureus (MRSA) between individual patients is difficult to track in institutions where MRSA is endemic. We investigated the transmission of MRSA where ST22-MRSA-IV is endemic on four wards using demographic data, patient and environmental screening, and molecular typing of isolates. A total of 939 patients were screened, 636 within 72 h of admission (on admission) and 303 >72 h after admission, and 1,252 environmental samples were obtained. Isolates were typed by spa, dru and pulsed-field gel electrophoresis (PFGE) typing. A composite dendrogram generated from the three sets of typing data was used to divide isolates into \\'dendrogram groups\\' (DGs). Ten percent of patients (92\\/939) were MRSA-positive; 7 % (44\\/636) on admission and 16 % (48\\/303) >72 h after admission (p = 0.0007). MRSA was recovered from 5 % of environmental specimens (65\\/1,252). Most isolates from patients (97 %, 85\\/88) and the environment (97 %, 63\\/65) exhibited the ST22-MRSA-IV genotype. Four DGs (DG1, DG4, DG16 and DG17) accounted for 58 % of ST22-MRSA-IV isolates from patients. Epidemiological evidence suggested cross-transmission among 44\\/92 patients (48 %) but molecular typing confirmed probable cross-transmission in only 11 instances (13 %, 11\\/88), with the majority of cross-transmission (64 %; 7\\/11) occurring on one ward. In the setting of highly clonal endemic MRSA, the combination of local epidemiology, PFGE, spa and dru typing provided valuable insights into MRSA transmission.

  18. Influence of Friends on Children’s Physical Activity: A Review

    Science.gov (United States)

    Maturo, Claire C.

    2013-01-01

    We examined evidence for friendship influences on children's physical activity (PA) through systematic searches of online databases in May 2012. We identified 106 studies (25 qualitative) published in English since 2000 that analyzed indicators of friendship influences (e.g., communication about PA, friends’ PA, and PA with friends) among persons younger than 19 years. Children's PA was positively associated with encouragement from friends (43 of 55 studies indicating a positive relationship), friends' own PA (30/35), and engagement with friends in PA (9/10). These findings are consistent with friends influencing PA, but most studies did not isolate influence from other factors that could explain similarity. Understanding friendship influences in childhood can facilitate the promotion of lifelong healthy habits. PA with friends should be considered in health promotion programs. PMID:23678914

  19. 18 January 2011 - Ing. Vittorio Malacalza, ASG Superconductors S.p.A, Italy in the LHC superconducting magnet test hall with Deputy Department Head L. Rossi, in the LHC tunnel at Point 5 and CMS experimental area with Spokesperson G. Tonelli.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    18 January 2011 - Ing. Vittorio Malacalza, ASG Superconductors S.p.A, Italy in the LHC superconducting magnet test hall with Deputy Department Head L. Rossi, in the LHC tunnel at Point 5 and CMS experimental area with Spokesperson G. Tonelli.

  20. The influence of leisure-time physical activity and lifestyle on a ...

    African Journals Online (AJOL)

    The influence of leisure-time physical activity and lifestyle on a coronary risk index ... African Journal for Physical Activity and Health Sciences ... from mid- and top management level from companies in South Africa participated in this survey.

  1. Influence of pulmonary surfactant on in vitro bactericidal activities of amoxicillin, ceftazidime, and tobramycin

    NARCIS (Netherlands)

    A. van 't Veen (Annemarie); J.W. Mouton (Johan); D.A.M.P.J. Gommers (Diederik); J.A.J.W. Kluytmans (Jan); P. Dekkers; B.F. Lachmann (Burkhard)

    1995-01-01

    textabstractThe influence of a natural pulmonary surfactant on antibiotic activity was investigated to assess the possible use of exogenous surfactant as a vehicle for antibiotic delivery to the lung. The influence of surfactant on the bactericidal activity of

  2. Self-monitoring of spontaneous physical activity and sedentary behavior to prevent weight regain in older adults.

    Science.gov (United States)

    Nicklas, Barbara J; Gaukstern, Jill E; Beavers, Kristen M; Newman, Jill C; Leng, Xiaoyan; Rejeski, W Jack

    2014-06-01

    The objective was to determine whether adding a self-regulatory intervention (SRI) focused on self-monitoring of spontaneous physical activity (SPA) and sedentary behavior to a standard weight loss intervention improved maintenance of lost weight. Older (65-79 years), obese (BMI = 30-40 kg/m(2) ) adults (n = 48) were randomized to a 5-month weight loss intervention involving a hypocaloric diet (DIET) and aerobic exercise (EX) with or without the SRI to promote SPA and decrease sedentary behavior (SRI + DIET + EX compared with DIET + EX). Following the weight loss phase, both groups transitioned to self-selected diet and exercise behavior during a 5-month follow-up. Throughout the 10-months, the SRI + DIET + EX group utilized real-time accelerometer feedback for self-monitoring. There was an overall group by time effect of the SRI (P DIET + EX lost less weight and regained more weight than SRI + DIET + EX. The average weight regain during follow-up was 1.3 kg less in the SRI + DIET + EX group. Individuals in this group maintained approximately 10% lower weight than baseline compared with those in the DIET + EX group whom maintained approximately 5% lower weight than baseline. Addition of a SRI, designed to increase SPA and decrease sedentary behavior, to a standard weight loss intervention enhanced successful maintenance of lost weight. Copyright © 2014 The Obesity Society.

  3. Radioprotector modifying influence upon the ion transport ATPase activities

    International Nuclear Information System (INIS)

    Dvoretsky, A.I.; Egorova, E.G.; Ananieva, T.V.; Kulikova, I.A.

    1993-01-01

    The effects of aminothiol and biogenic amine radioprotectors (β-mercaptoethylamine, AET, serotonin, dopamine, histamine) on the basic ion transport enzymes, such as Na, K-ATP ase and Mg, Ca-ATPase activities were investigated in the tissues of numerous organs, with different radiosensitivity in the wistar rats. Experimental results showed that intraperitoneal injection of the used radioprotectors caused preliminary inhibition of the Na, K-ATPase activity in tissues from organs with different radioresistance, but had no influence on the Mg, Ca-ATPase activity in membranes of erythrocytes and rat brain cells. (2 tabs.)

  4. The influence of attitudes toward physical activity and sports

    Directory of Open Access Journals (Sweden)

    Ana Tereza Araújo

    2015-12-01

    Full Text Available Abstract Attitude is one of the most important predictor variables in relation to behavioral intentions regarding physical activity. Thus, this study aims to determine the influence of attitudes towards physical activity. The study comprised a sample of 1129 individuals (507 men and 622 women age between 12 and 58 years ( = 18 sd = 4.03. To collect the data, the Scale of Attitudes Towards Physical Activity and Sports (Dosil, 2002 was based on the Portuguese version (Cid, Alves, & Dosil, 2008. The results show that attitudes towards physical activity and sports are more positive in younger male individuals, who do not attend higher education, who regularly engage in physical activity and whose parents engage in physical/sports activity themselves.

  5. Chemical composition of the thermomineral waters of Josanicka Banja spa as an origin indicator, balneological valorization and geothermal potential

    Directory of Open Access Journals (Sweden)

    Milenić Dejan R.

    2015-01-01

    Full Text Available The chemical composition of the groundwater is directly dependent on the geological structure, hydrogeological and hydrochemical characteristics and as such it represents an output result of all the factors and processes which take place in the environment within which they were formed. The chemical composition of thermomineral waters often represents a crucial factor in determining the origin, balneological valorization and geothermal potential of the resources. This work presents the analysis of origin, belneological valorization and geothermal potential of Josanicka Banja spa, on the basis of the results gained through making the analyisis of chemical contents of the thermomineral waters which occur in the area. The ratio of concentrations of specific chemical components in the thermomineral waters of Josanicka Banja has served as the basic tool for ascertaining the origin of these waters. On the basis of the analysis of the main anion-cation and gas compositions as well as the contents of specific micro-components, a balneological valorization of these resources has been carried out. Apart from that this work also presents the calculation of the expected temperatures in the primary geothermal reservoir, which was carried out on the basis of the results of chemical analysis of thermomineral waters that occur in the area. Geothermal potential of about 4 MWt and significant contents of balneologically active components of the chemical composition of these waters, open up a possibility for their multi-purpose use, which is also presented in the work. [Projekat Ministarstva nauke Republike Srbije, br. TR 33053

  6. The detailed analysis of natural radionuclides dissolved in spa waters of the Kłodzko Valley, Sudety Mountains, Poland

    Energy Technology Data Exchange (ETDEWEB)

    Walencik-Łata, A., E-mail: agata.walencik@us.edu.pl [University of Silesia, Institute of Physics, Department of Nuclear Physics and Its Applications, Uniwersytecka 4 St., 40-007 Katowice (Poland); Kozłowska, B.; Dorda, J. [University of Silesia, Institute of Physics, Department of Nuclear Physics and Its Applications, Uniwersytecka 4 St., 40-007 Katowice (Poland); Przylibski, T.A. [Wrocław University of Technology, Faculty of Geoengineering, Mining and Geology, Division of Geology and Mineral Waters, Wybrzeże S. Wyspiańskiego 27, 50-370 Wrocław (Poland)

    2016-11-01

    A survey was conducted to measure natural radioactivity in spa waters from the Kłodzko Valley. The main goal of this study was to determine the activity concentration of uranium, radium and radon isotopes in the investigated groundwaters. Samples were collected several times from 35 water intakes from 5 spas and 2 mineral water bottling plants. The authors examined whether the increased gamma radiation background, as well as the elevated values of radium and uranium content in reservoir rocks, have a significant impact on the natural radioactivity of these waters. The second objective of this research was to provide information about geochemistry of U, Ra, Rn radionuclides and the radiological and chemical risks incurred by ingestion of isotopes with drinking water. On the basis of results obtained, it is feasible to assess the health hazard posed by ingestion of natural radioactivity with drinking waters. Moreover, the data yielded by this research may be helpful in the process of verification of the application of these waters in balneotherapy. In addition, annual effective radiation doses resulting from the isotopes consumption were calculated on the basis of the evaluated activity concentrations. In dose assessment for uranium and radium isotopes, the authors provided values for different human age groups. The obtained uranium content in the investigated waters was compared with the currently valid regulations concerning the quality of drinking water. Based on the activity concentrations data, the activity isotopic ratios {sup 234}U/{sup 238}U, {sup 226}Ra/{sup 238}U, {sup 222}Rn/{sup 238}U, {sup 222}Rn/{sup 226}Ra and the correlations between radionuclides content were then examined. In brief, it may be concluded on the basis of the obtained results that radon solubility is inversely proportional to radium and uranium dissolution in environmental water circulation. The presented study allows conclusions to be drawn on the radionuclide circulation among

  7. Measuring and influencing physical activity with smartphone technology: a systematic review.

    Science.gov (United States)

    Bort-Roig, Judit; Gilson, Nicholas D; Puig-Ribera, Anna; Contreras, Ruth S; Trost, Stewart G

    2014-05-01

    Rapid developments in technology have encouraged the use of smartphones in physical activity research, although little is known regarding their effectiveness as measurement and intervention tools. This study systematically reviewed evidence on smartphones and their viability for measuring and influencing physical activity. Research articles were identified in September 2013 by literature searches in Web of Knowledge, PubMed, PsycINFO, EBSCO, and ScienceDirect. The search was restricted using the terms (physical activity OR exercise OR fitness) AND (smartphone* OR mobile phone* OR cell phone*) AND (measurement OR intervention). Reviewed articles were required to be published in international academic peer-reviewed journals, or in full text from international scientific conferences, and focused on measuring physical activity through smartphone processing data and influencing people to be more active through smartphone applications. Two reviewers independently performed the selection of articles and examined titles and abstracts to exclude those out of scope. Data on study characteristics, technologies used to objectively measure physical activity, strategies applied to influence activity; and the main study findings were extracted and reported. A total of 26 articles (with the first published in 2007) met inclusion criteria. All studies were conducted in highly economically advantaged countries; 12 articles focused on special populations (e.g. obese patients). Studies measured physical activity using native mobile features, and/or an external device linked to an application. Measurement accuracy ranged from 52 to 100% (n = 10 studies). A total of 17 articles implemented and evaluated an intervention. Smartphone strategies to influence physical activity tended to be ad hoc, rather than theory-based approaches; physical activity profiles, goal setting, real-time feedback, social support networking, and online expert consultation were identified as the most useful

  8. Bioactive food stimulants of sympathetic activity: effect on 24-h energy expenditure and fat oxidation.

    Science.gov (United States)

    Belza, A; Jessen, A B

    2005-06-01

    Bioactive food ingredients influence energy balance by exerting weak thermogenic effects. We studied whether the thermogenic effect of a combination of capsaicin, green tea extract (catechins and caffeine), tyrosine, and calcium was maintained after 7-day treatment and whether local effects in the gastric mucosa were involved in the efficacy. The present study was designed as a 3-way crossover, randomised, placebo-controlled, double-blinded intervention. Department of Human Nutrition, RVAU, Denmark. A total of 19 overweight to obese men (BMI: 28.0+/-2.7 kg/m2) were recruited by advertising locally. The subjects took the supplements for a period of 7 days. The supplements were administrated as a simple supplement with the bioactive ingredients, a similar enterocoated version, or placebo. In all, 24-h energy expenditure (EE), substrate oxidations, spontaneous physical activity (SPA), and heart rate were measured in respiration chambers on the seventh day of each test period. After adjustment for changes in body weight and SPA, 24-h EE was increased by 160 kJ/day (95% CI: 15-305) by the simple preparation as compared to placebo, whereas the enterocoated preparation had no such effect (53 kJ/day, -92 to 198); simple vs enterocoated versions (P=0.09). The simple preparation produced a deficit in 24-h energy balance of 193 kJ/day (49-338, P=0.03). Fat and carbohydrate oxidation were equally increased by the supplements. A supplement containing bioactive food ingredients increased daily EE by approximately 200 kJ or 2%, without raising the heart rate or any observed adverse effects. The lack of effect of the enterocoated preparation suggests that a local action of capsaicin in the gastric mucosa is a prerequisite for exerting the thermogenic effect.

  9. Solar activity influence on air temperature regimes in caves

    Science.gov (United States)

    Stoeva, Penka; Mikhalev, Alexander; Stoev, Alexey

    Cave atmospheres are generally included in the processes that happen in the external atmosphere as circulation of the cave air is connected with the most general circulation of the air in the earth’s atmosphere. Such isolated volumes as the air of caves are also influenced by the variations of solar activity. We discuss cave air temperature response to climate and solar and geomagnetic activity for four show caves in Bulgaria studied for a period of 46 years (1968 - 2013). Everyday noon measurements in Ledenika, Saeva dupka, Snezhanka and Uhlovitsa cave have been used. Temperatures of the air in the zone of constant temperatures (ZCT) are compared with surface temperatures recorded at meteorological stations situated near about the caves - in the towns of Vratsa, Lovech, Peshtera and Smolyan, respectively. For comparison, The Hansen cave, Middle cave and Timpanogos cave from the Timpanogos Cave National Monument, Utah, USA situated nearly at the same latitude have also been examined. Our study shows that the correlation between cave air temperature time series and sunspot number is better than that between the cave air temperature and Apmax indices; that t°ZCT is rather connected with the first peak in geomagnetic activity, which is associated with transient solar activity (CMEs) than with the second one, which is higher and connected with the recurrent high speed streams from coronal holes. Air temperatures of all examined show caves, except the Ledenika cave, which is ice cave show decreasing trends. On the contrary, measurements at the meteorological stations show increasing trends in the surface air temperatures. The trend is decreasing for the Timpanogos cave system, USA. The conclusion is that surface temperature trends depend on the climatic zone, in which the cave is situated, and there is no apparent relation between temperatures inside and outside the caves. We consider possible mechanism of solar cosmic rays influence on the air temperatures in caves

  10. Disease activity decrease is associated with improvement in work productivity over 1 year in early axial spondyloarthritis (SPondyloArthritis Caught Early cohort)

    NARCIS (Netherlands)

    van Lunteren, Miranda; Ez-Zaitouni, Zineb; Fongen, Camilla; Landewé, Robert; Ramonda, Roberta; van der Heijde, Désirée; van Gaalen, Floris A.

    2017-01-01

    To assess if a change in disease activity is associated with a change in work productivity loss (WPL) over 1 year in early axial SpA (axSpA) patients. Baseline and 1 year data of axSpA patients in the SPondyloArthritis Caught Early cohort were analysed. Linear regression models were built explaining

  11. Influence of decreased fibrinolytic activity and plasminogen activator inhibitor-1 4G/5G polymorphism on the risk of venous thrombosis.

    Science.gov (United States)

    Vuckovic, Biljana A; Djeric, Mirjana J; Tomic, Branko V; Djordjevic, Valentina J; Bajkin, Branislav V; Mitic, Gorana P

    2018-01-01

    : Objective of our study is to determine whether decreased fibrinolytic activity or plasminogen activator inhibitor (PAI)-1 4G/5G polymorphism influence the risk of venous thrombosis.Our case-control study included 100 patients with venous thrombosis, and 100 random controls. When patients were compared with random controls, unconditional logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs).Decreased fibrinolytic activity yielded a 2.7-fold increase in risk for venous thrombosis than physiological fibrinolytic activity (OR 2.70; 95% CI 1.22-5.98), when comparing patients with random controls. Adjustment for several putative confounders did not change the estimate (OR 3.02; 95% CI 1.26-7.22). Analysis of venous thrombotic risk influenced by PAI-1 genotype, showed no influence of PAI-1 4G/5G gene variant in comparison with 5G/5G genotype (OR 0.57 95% CI; 0.27-1.20).Decreased fibrinolytic activity increased, whereas PAI-1 4G/5G polymorphism did not influence venous thrombosis risk in this study.

  12. Learning with companies (LeWiCo through the use of Facebook in the context of vocational hospitality education and digital spa marketing

    Directory of Open Access Journals (Sweden)

    Annica Isacsson

    2016-01-01

    The article adopts a case study approach to describe in detail how Facebook was used to foster self-directed and co-constructive learning in a social environment. The findings presented in the article are based on the postings of participating students in Facebook, and on teachers and project team reflections. Overall, the project was a success and led to the construction of a useful, current and engaging knowledge base in the context of spa marketing. Moreover, the students appreciated the informal learning environment, and the teachers learned how to enhance learning without suffocating the learning process with too many guidelines or information. The students learned how to collaborate independently, and in pairs, and to take responsibility of their own learning.

  13. Hydrogeothermal resources in spa areas of Serbia: Main properties and possible improvement of use

    Directory of Open Access Journals (Sweden)

    Dokmanović Petar B.

    2012-01-01

    Full Text Available Geological complexity of the territory of Serbia is a world curiosity: six main geo-tectonic regions and tens sub-regions are delineated in a small area of 88,000 km2. Geologic origin and regional structure of some areas has long been the subject of discussion. Notable magmatism and associated tectonic events in the Earth's crust provided for a fairly large hydrogeothermal resource potential, which is manifested in more than 250 warm (mainly mineral springs and more than 100 hydrothermal wells. Thermal springs and wells together discharge some 5 m3/s. This potential is used in part for balneal therapy (waters differ in temperature and chemical composition in the spa areas of Serbia. The amounts of thermal water unused therapeutically or the amounts of heat energy from unused geo-thermal water may be used in almost all spas for space heating/cooling and thus increase the efficiency of the thermal water energy utilization. This also will be cost-effective, reduce emission of noxious gases, and improve the environmental-health image of the resorts. The hydrogeothermal resources are described for 29 spas with 700 l/s total discharge capacity of water temperature between 25°C and 96ºC, or an overall heat energy of 78.40 MWt. Feasibility of additional energy utilization of thermal water in spas is generally considered.

  14. Well known outstanding geoid and relief depressions as regular wave woven features on Eartg (Indian geoid minimum), Moon (SPA basin), Phobos (Stickney crater), and Miranda (an ovoid).

    Science.gov (United States)

    Kochemasov, Gennady G.

    2010-05-01

    A very unreliable interpretation of the deepest and large depressions on the Moon and Phobos as the impact features is not synonymous and causes many questions. A real scientific understanding of their origin should take into consideration a fact of their similar tectonic position with that of a comparable depression on so different by size, composition, and density heavenly body as Earth. On Earth as on other celestial bodies there is a fundamental division on two segments - hemispheres produced by an interference of standing warping wave 1 (long 2πR) of four directions [1]. One hemisphere is uplifted (continental, highlands) and the opposite subsided (oceanic, lowlands). Tectonic features made by wave 2 (sectors) adorn this fundamental structure. Thus, on the continental risen segment appear regularly disposed sectors, also uplifted and subsided. On the Earth's eastern continental hemisphere they are grouped around the Pamirs-Hindukush vertex of the structural octahedron made by interfering waves2. Two risen sectors (highly uplifted African and the opposite uplifted Asian) are separated by two fallen sectors (subsided Eurasian and the opposite deeply subsided Indoceanic). The Indoceanic sector with superposed on it subsided Indian tectonic granule (πR/4-structure) produce the deepest geoid minimum of Earth (-112 m). The Moon demonstrates its own geoid minimum of the same relative size and in the similar sectoral tectonic position - the SPA basin [2, 3]. This basin represents a deeply subsided sector of the sectoral structure around the Mare Orientale (one of vertices of the lunar structural octahedron). To this Mare converge four sectors: two subsided - SPA basin and the opposite Procellarum Ocean, and two uplifted - we call them the "Africanda sector" and the opposite "Antiafricanda one" to stress structural similarity with Earth [2]. The highest "Africanda sector" is built with light anorthosites; enrichment with Na makes them even less dense that is required

  15. Wood Road School, Ballston Spa, New York solar-energy-system performance evaluation, November 1981-April 1982

    Energy Technology Data Exchange (ETDEWEB)

    Kendall, P.

    1982-01-01

    The Wood Road School Solar Project of the Ballston Spa Central School District is a 216,000 square foot (136,510 square feet of solar conditioned space) combined elementary and middle school located in New York. The solar energy system was designed to supply 64% of the space heating and 88% of the hot water. The system is equipped with 15,389 square feet of one type of flat-plate collector panels and 6650 square feet of another type. Storage is in two 15,000-gallon storage tanks, and auxiliary heating is by electric resistance strip heaters. Monthly performance data are tabulated for the overall system and for each type of collector, storage, domestic hot water, and space heating subsystems. Also tabulated monthly are weather conditions, energy savings, operating energy, and coefficients of performance. Also provided are graphs of collector array efficiency vs the difference between the fluid inlet temperature and ambient temperature divided by insolation. System operation is illustrated by graphs of collector array inlet/outlet temperatures and ambient temperature and typical building loop temperatures vs time for a typical day. Also graphed are the system operating sequence and the solar energy utilization and energy losses. (LEW)

  16. Dating Melt Rock 63545 By Rb-Sr and Sm-Nd: Age of Imbrium; Spa Dress Rehearsal

    Science.gov (United States)

    Nyquist, L. E.; Shih, C. Y.; Reese, Y. D.

    2011-01-01

    Apollo 16 sample 63545 was initially described as one of a group of 19 generally rounded, fine-grained, crystalline rocks that were collected as rake samples [1]. This 16 g "rocklet" was collected at Station 13 on the ejecta blanket of North Ray Crater at the foot of Smoky Mountain [2]. Originally classified as a Very High Alumina (VHA) basalt on geochemical grounds [3], it was later argued to be an impact melt rock [4]. Here we report a Rb-Sr and Sm-Nd isotopic study that shows that some portions of the rock failed to reach isotopic equilibrium on last melting in agreement with the impact melt rock interpretation. Nevertheless, by omitting mineral fractions that are discordant with the majority of the data, we arrive at the time of last melting as 3.88 plus or minus 0.05 Ga ago. This age is in agreement with the Ar-39/Ar-40 plateau age of 3839 plus or minus 23 Ma [5], if the latter is adjusted for the 1.4-1.8% revision in the age of the hornblende monitor [6]. This investigation was undertaken in part as proof-of-concept for SPA-basin sample return.

  17. Work productivity in a population-based cohort of patients with spondyloarthritis.

    Science.gov (United States)

    Haglund, Emma; Bremander, Ann; Bergman, Stefan; Jacobsson, Lennart T H; Petersson, Ingemar F

    2013-09-01

    To assess work productivity and associated factors in patients with SpA. This cross-sectional postal survey included 1773 patients with SpA identified in a regional health care register. Items on presenteeism (reduced productivity at work, 0-100%, 0 = no reduction) were answered by 1447 individuals. Absenteeism was defined as register-based sick leave using data from a national register. Disease duration, disease activity (BASDAI), physical function (BASFI), health-related quality of life (EQ-5D), anxiety (HAD-a), depression (HAD-d), self-efficacy [Arthritis Self-efficacy Scale (ASES) pain and symptom], physical activity and education were also measured. Forty-five per cent reported reduced productivity at work with a mean reduction of 20% (95% CI 18, 21) and women reported a higher mean reduction than men (mean 23% vs 17%, P productivity (r = 0.52-0.66, P productivity at work in patients with SpA regardless of age, gender and disease subgroup. ASES symptoms, HAD-a and education level productivity but were not significant in all strata for age, gender and disease subgroup. Work productivity was reduced in patients with SpA and more so in women. Worse quality of life, disease activity, physical function, self-efficacy and depression were all associated with reduced productivity at work in patients with SpA.

  18. Perceptual incongruence influences bistability and cortical activation.

    Directory of Open Access Journals (Sweden)

    Gijs Joost Brouwer

    Full Text Available We employed a parametric psychophysical design in combination with functional imaging to examine the influence of metric changes in perceptual incongruence on perceptual alternation rates and cortical responses. Subjects viewed a bistable stimulus defined by incongruent depth cues; bistability resulted from incongruence between binocular disparity and monocular perspective cues that specify different slants (slant rivalry. Psychophysical results revealed that perceptual alternation rates were positively correlated with the degree of perceived incongruence. Functional imaging revealed systematic increases in activity that paralleled the psychophysical results within anterior intraparietal sulcus, prior to the onset of perceptual alternations. We suggest that this cortical activity predicts the frequency of subsequent alternations, implying a putative causal role for these areas in initiating bistable perception. In contrast, areas implicated in form and depth processing (LOC and V3A were sensitive to the degree of slant, but failed to show increases in activity when these cues were in conflict.

  19. [Adsorbent effect of activated carbon on small molecular uremic toxin and its influence factors].

    Science.gov (United States)

    Yang, Bo; Jiang, Yun-sheng; Li, Jun

    2003-06-01

    To analyze the adsorbent effect of activated carbon on uremic toxin and its influence factors. Uremic toxins (urea, creatinine and uric acid) were dissolved in the distilled water to obtain uremic toxic solution. Activated carbon was added to the solution, and the concentrations of uremic toxins were measured at different time spots. To determine the influence factors, some possible related materials, such as bile, amino acid, Ringer's, solution of glucose, HCl or NaOH respectively were added simultaneously. The concentrations of toxins in uremic toxic solution decreased 5 min after adding the activated carbon. The concentration of urea was the lowest at 30 min, but it increased after 50 min; while the concentrations of creatinine and uric acid reached the lowest level from 10 to 30 min after adding the activated carbon, and maintained at the same level after that. The bile, amino acid, electrolyte, glucose and pH value did not influence the adsorption of uric acid significantly, but they influenced the adsorption of urea and creatinine. Bile and amino acid influenced the concentration of urea remarkably, following glucose, NaOH and HCl. The effect of pH 2.0 solution on the creatinine concentration was the most significant, following glucose. Activated carbon has adsorptive effect on uremic toxins, but its adsorptive effect decreases as time goes on. Bile, glucose, amino acid, NaOH and HCl can affect the adsorptive effect of activated carbon on uremic toxins to some extent.

  20. Treatment of knee OSTEOARTHRITIS in Spa Health resorts: where do we stand?

    Directory of Open Access Journals (Sweden)

    Salca Amalia

    2015-09-01

    Full Text Available Osteoarthrosis (OA includes degenerative joint disorders that affect articular cartilage in the first instance, followed by changes of all components of the joint. The disease is detected in a proportion of 33% by X-ray in patients aged over 60 years. Knee OA (KOA ranks first among chronic diseases from the point of view of patient disability. This article is a review of guidelines and articles regarding arthrosis, balneotherapy, and balneotherapy in KOA treatment. These were accessed on the Pubmed site in the period March-April 2015. The components of balneo-therapy to which the selected articles refer include mud packs, mineral waters, climate change. These are evaluated in association or in comparison with other methods used in the rehabilitation specialty area for the treatment of KOA: kinesitherapy, intra-articular infiltrations, hydrothermotherapy. The changes induced by these therapies on clinical evolution (pain relief, tenderness, functionality, quality of life, depression symptoms or certain serum parameters (biomarkers of oxidative stress, inflammation and cartilage destruction, vitamin D and other serum metabolites were recorded. The results of our review are consistent with the studies focused on spa modalities in all types of OA. All these data helped defining the role of balneotherapy as part of the rehabilitation program for the treatment of KOA, through the benefits specific to it. Conclusion: Balneotherapy has beneficial effects on patients with KOA, both clinically and serologic improvements. Further studies are needed to quantify these effects using KOA specific markers, to establish a hierarchy of balneotherapy methods based on their effects on KOA, as well as to refine indications depending on the stage of the disease.

  1. Influence of early pH decline on calpain activity in porcine muscle

    DEFF Research Database (Denmark)

    Pomponio, Luigi; Ertbjerg, Per; Karlsson, Anders H

    2010-01-01

    myofibril fragmentation at 24 h post-mortem was observed, which was no longer evident in the later phase of the tenderization process. In conclusion, the rate of early pH decline influenced l-calpain activity and the rate but not the extent of myofibrillar degradation, suggesting an early effect......This study investigated the influence of post-mortem pH decline on calpain activity and myofibrillar degradation.From 80 pigs, 30 Longissimus dorsi (LD) muscles were selected on the basis of pH values at 3 h post-mortem and classified into groups of 10 as fast, intermediate and slow pH decline...... measured. A faster decrease in pH resulted in reduced level of l-calpain activity and increased autolysis of the enzyme, and hence an earlier loss of activity due to activation of l-calpain in muscles with a fast pH decline. Paralleling the l-calpain activation in muscles with a fast pH decline a higher...

  2. [Analysis of the effectiveness of the spa and health resort-based treatment of the patients presenting with broncho-pulmonary pathology at the southern coast of the Crimea depending on the period of flowering of Mediterranean Cypress (Cupressus sempervirens)].

    Science.gov (United States)

    Savchenko, V M; Belyaeva, S N; Govorun, M I; Pirogova, M E

    The objective of the present study was to evaluate the influence of pollen of Mediterranean Cypress (Cupressus sempervirens) on the effectiveness of the spa and health resort-based treatment (SHRT) of the patients with broncho-pulmonary pathology at the southern coast of the Crimea (SCC). This article presents the results of the analysis of the data on 122 patients presenting with broncho-pulmonary pathology who received SHRT under the conditions of the Southern Coast of the Crimea. Fifty one (41.8%) of these patients suffered from chronic obstructive pulmonary disease and 71 (58.2%) ones had bronchial asthma. The whole group was comprised of 44 men (36.1%) and 78 women (63.9%). The average (median) age of the patients was 55.8 years. All the participants of the study underwent the comprehensive examination including the general medical and physical examination, complete blood count, the study of sputum cytology and immunological properties of blood including the standard characteristics, IgE and lysozyme levels), evaluation of the respiratory and locomotor (physical) functions with the use of the 6-minute walking test. The aeropollenological study of the aerial environment of the southern coast of the Crimea in the region of Yalta showed that the «bloom» of the Mediterranean Cypress occurs during the period from February till April inclusive. The highest concentrations of cypress pollen are observed in March and early April. The overall effectiveness of SHRT for the patients with broncho-pulmonary pathology arriving for the treatment at the southern coast of the Crimea from other Crimean localities does not depend on the period of «flowering» (the presence of pollen in the air) of the Mediterranean Cypress. In these patients, the termination of the spa and health resort-based treatment during the «flowering» of the Mediterranean Cypress resulted in nothing more than a strained adaptive response manifested as the altered blood leukocyte count. Such reaction

  3. Adolescent Involvement in Extracurricular Activities: Influences on Leadership Skills

    Science.gov (United States)

    Hancock, Donna; Dyk, Patricia Hyjer; Jones, Kenneth

    2012-01-01

    Study examined adolescents' participation in sports, school, and community extracurricular activities to assess the influence of different involvement roles and adult support on leadership skills. The study found that males and females who perceived their adult support more positively had more positive perceptions of their leadership skills.…

  4. Influences on seizure activity in pregnant women with epilepsy

    DEFF Research Database (Denmark)

    Sabers, Anne

    2009-01-01

    This study evaluated whether referral to a specialized epilepsy clinic prior to pregnancy influences seizure activity during pregnancy. In addition, folic acid supplementation prior to pregnancy as a marker of intent to conceive was used to evaluate whether the use of folic acid at the time of co...

  5. Predictive Factors of Clinical Response of Infliximab Therapy in Active Nonradiographic Axial Spondyloarthritis Patients

    Directory of Open Access Journals (Sweden)

    Zhiming Lin

    2015-01-01

    Full Text Available Objectives. To evaluate the efficiency and the predictive factors of clinical response of infliximab in active nonradiographic axial spondyloarthritis patients. Methods. Active nonradiographic patients fulfilling ESSG criteria for SpA but not fulfilling modified New York criteria were included. All patients received infliximab treatment for 24 weeks. The primary endpoint was ASAS20 response at weeks 12 and 24. The abilities of baseline parameters and response at week 2 to predict ASAS20 response at weeks 12 and 24 were assessed using ROC curve and logistic regression analysis, respectively. Results. Of 70 axial SpA patients included, the proportions of patients achieving an ASAS20 response at weeks 2, 6, 12, and 24 were 85.7%, 88.6%, 87.1%, and 84.3%, respectively. Baseline MRI sacroiliitis score (AUC = 0.791; P=0.005, CRP (AUC = 0.75; P=0.017, and ASDAS (AUC = 0.778, P=0.007 significantly predicted ASAS20 response at week 12. However, only ASDAS (AUC = 0.696, P=0.040 significantly predicted ASAS20 response at week 24. Achievement of ASAS20 response after the first infliximab infusion was a significant predictor of subsequent ASAS20 response at weeks 12 and 24 (wald χ2=6.87, P=0.009, and wald χ2=5.171, P=0.023. Conclusions. Infliximab shows efficiency in active nonradiographic axial spondyloarthritis patients. ASDAS score and first-dose response could help predicting clinical efficacy of infliximab therapy in these patients.

  6. Tools for monitoring spondyloarthritis in clinical practice

    NARCIS (Netherlands)

    van Tubergen, Astrid M.; Landewé, Robert B. M.

    2009-01-01

    Spondyloarthritis (SpA) usually follows a chronic disease course that requires regular medical care and monitoring to control for increased disease activity and to maintain physical function. This Review describes the instruments and imaging techniques available for monitoring SpA in clinical

  7. Expression of Peroxisome Proliferator-Activated Receptor-γ in Key Neuronal Subsets Regulating Glucose Metabolism and Energy Homeostasis

    OpenAIRE

    Sarruf, David A.; Yu, Fang; Nguyen, Hong T.; Williams, Diana L.; Printz, Richard L.; Niswender, Kevin D.; Schwartz, Michael W.

    2008-01-01

    In addition to increasing insulin sensitivity and adipogenesis, peroxisome proliferator-activated receptor (PPAR)-γ agonists cause weight gain and hyperphagia. Given the central role of the brain in the control of energy homeostasis, we sought to determine whether PPARγ is expressed in key brain areas involved in metabolic regulation. Using immunohistochemistry, PPARγ distribution and its colocalization with neuron-specific protein markers were investigated in rat and mouse brain sections spa...

  8. The influence of activities and nutrition status to university students' achievements

    Science.gov (United States)

    Fathonah, Siti

    2018-03-01

    The purpose of this research is to analyse the influence of activity and nutrition status to the achievement of students from Engineering Faculty of UNNES. The subject of this research is the students of Engineering Faculty of UNNES. Using proportional random sampling, there are 5% (214 students of 2015 batch) taken as the samples of the research. The methods of collecting the data were using documentation from akademik.unnes.ac.id on students' achievement, questionnaire to ask upon students' activity, and BMI measurement for nutrition status. The data analysis was using percentage description, chi-square analysis, and regression. The data obtained that the average grade points of engineering students are satisfying in the level of 3.29 with light activities with the energy of 2.220 kkal. The average sleeping time of the students were 5.68 hours, whereas the total of their studying and private activity were 18.18 hours. The status of students' nutrition is Normal weight with the details of 64.2% of students are Normal weight, 23.5% of them are wasting, 4.0% are overweight, and 5.2% are obesity. The activity and nutrition status were proven not significantly influencing students grade point of achievements. The suggestions proposed by the researcher are 1) the students need to increase their sleeping time to be 6-9 hours, and they need to habituate themselves in working out at least 3 times a week in 30 - 45 minutes, and 2) further research on nutrition status and students' achievements can focus on the influence of food consumption and students' clean lifestyle.

  9. Activity, content, contributors, and influencers of the twitter discussion on urologic oncology.

    Science.gov (United States)

    Borgmann, Hendrik; Loeb, Stacy; Salem, Johannes; Thomas, Christian; Haferkamp, Axel; Murphy, Declan G; Tsaur, Igor

    2016-09-01

    To analyse the activity, content, contributors, and influencers of the Twitter discussion on urologic oncology. We performed a comprehensive quantitative and qualitative Twitter analysis for the hashtags #prostatecancer, #bladdercancer, #kidneycancer, and #testicularcancer. Symplur was used to analyse activity over different time periods and the top influencers of the Twitter discussion. Tweet Archivist and Twitonomy analysis tools were used to assess characteristics of content and contributors. Twitter discussion on urologic oncology in 2014 contained 100,987 tweets created by 39,326 participants. Mean monthly tweet activity was 6,603±2,183 for #prostatecancer, 866±923 for #testicularcancer, 457±477 for #bladdercancer and 401±504 for #kidneycancer. Twitter activity increased by 41% in 2013 and by 122% in 2014. The content analysis detected awareness, cancer, and risk as frequently mentioned words in urologic oncology tweets. Prevalently used related hashtags were the general hashtag #cancer, awareness hashtags, and the respective cancer/urology tag ontology hashtags. Contributors originated from 41 countries on 6 continents and had a mean of 5,864±4,747 followers. They tweeted from platforms on exclusively mobile devices (39%) more frequently than from desktop devices (29%). Health care organizations accounted for 58% of the top influencers in all cancers. The largest proportion of physicians were among the #prostatecancer and #kidneycancer (each 9%) influencers and individual contributors were most frequent in the discussion on #kidneycancer (57%) and #testicularcancer (50%). There is a significant and growing activity in the Twitter discussion on urologic oncology, particularly on #prostatecancer. The Twitter discussion is global, social, and mobile, and merits attention of stakeholders in health care as a promising communication tool. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. Perceived influence of intrinsic/extrinsic factors on participation in life activities after spinal cord injury.

    Science.gov (United States)

    Cobb, John E; Leblond, Jean; Dumont, Frédéric S; Noreau, Luc

    2018-04-03

    Various types of limitations on community participation are experienced by people with spinal cord injury (SCI). To determine: 1) the perceived influence of six intrinsic/extrinsic factors (i.e. physical impairment, emotional condition, thinking skills, environment, lack of assistance, discrimination) on participation in 26 life activities, 2) if this influence varied based on extent of participation, and 3) if personal or environmental characteristics influenced perceptions. Secondary analysis of a cohort (SCI Community Survey, n = 1508) using the SCI Person-Perceived Participation in Daily Activities Questionnaire. Frequency tables, Fisher's exact tests and correspondence analyses. Respectively, 79.6% and 38.5% of respondents perceived that their physical impairment and the natural and/or built environment were the main factors that limited participation across all activities. Considering participation between three groups (no participation; less than wanted; as much as wanted), significant differences (p intrinsic/extrinsic factors on participation was not significantly influenced by other personal or environmental characteristics. A majority of people with SCI perceived that their participation is limited by one or more of intrinsic/extrinsic factors. Perceptions regarding which factors influence participation differ between activities and these perceptions appear related to the extent of participation suggesting that those who actively participate could be the most sensitive to limitations in certain activities. Copyright © 2018 Elsevier Inc. All rights reserved.

  11. Self-Schemata for Movement Activities: The Influence of Race and Gender.

    Science.gov (United States)

    Harrison, Louis, Jr.; And Others

    This study investigated the influence of race and gender on students' self-schema for movement activities. Study participants were 168 male and female seventh- and eighth-grade students, both African American and Euro American, from a semi-rural school in a Southeastern state. The Physical Activity Schema Analysis (PASA) was administered to…

  12. Activating lay health influencers to promote tobacco cessation.

    Science.gov (United States)

    Muramoto, Myra L; Hall, John R; Nichter, Mark; Nichter, Mimi; Aickin, Mikel; Connolly, Tim; Matthews, Eva; Campbell, Jean Z; Lando, Harry A

    2014-05-01

    To evaluate the effect of tobacco cessation brief-intervention (BI) training for lay "health influencers," on knowledge, self-efficacy and the proportion of participants reporting BI delivery post-training. Randomized, community-based study comparing In-person or Web-based training, with mailed materials. In-person and Web-training groups had significant post-training cessation knowledge and self-efficacy gains. All groups increased the proportion of individuals reporting BIs at follow-up, with no significant between-group differences. Irrespective of participants' prior intervention experience, 80%-86% reported BIs within the past 90 days; 71%-79% reported >1 in the past 30. Web and In-person training significantly increase health influencer cessation knowledge and self-efficacy. With minimal prompting and materials, even persons without BI experience can be activated to encourage tobacco cessation.

  13. The influence of human physical activity and contaminated clothing type on particle resuspension

    International Nuclear Information System (INIS)

    McDonagh, A.; Byrne, M.A.

    2014-01-01

    A study was conducted to experimentally quantify the influence of three variables on the level of resuspension of hazardous aerosol particles from clothing. Variables investigated include physical activity level (two levels, low and high), surface type (four different clothing material types), and time i.e. the rate at which particles resuspend. A mixture of three monodisperse tracer-labelled powders, with median diameters of 3, 5, and 10 microns, was used to “contaminate” the samples, and the resuspended particles were analysed in real-time using an Aerodynamic Particle Sizer (APS), and also by Neutron Activation Analysis (NAA). The overall finding was that physical activity resulted in up to 67% of the contamination deposited on clothing being resuspended back into the air. A detailed examination of the influence of physical activity level on resuspension, from NAA, revealed that the average resuspended fraction (RF) of particles at low physical activity was 28 ± 8%, and at high physical activity was 30 ± 7%, while the APS data revealed a tenfold increase in the cumulative mass of airborne particles during high physical activity in comparison to that during low physical activity. The results also suggest that it is not the contaminated clothing's fibre type which influences particle resuspension, but the material's weave pattern (and hence the material's surface texture). Investigation of the time variation in resuspended particle concentrations indicated that the data were separable into two distinct regimes: the first (occurring within the first 1.5 min) having a high, positive rate of change of airborne particle concentration relative to the second regime. The second regime revealed a slower rate of change of particle concentration and remained relatively unchanged for the remainder of each resuspension event. -- Highlights: • Experimental investigation of the resuspension of hazardous particles from clothing. • Influence of human physical activity

  14. Variable activation in striatal subregions across components of a social influence task in young adult cannabis users.

    Science.gov (United States)

    Gilman, Jodi M; Lee, Sang; Kuster, John K; Lee, Myung Joo; Kim, Byoung Woo; van der Kouwe, Andre; Blood, Anne J; Breiter, Hans C

    2016-05-01

    Decades of research have demonstrated the importance of social influence in initiation and maintenance of drug use, but little is known about neural mechanisms underlying social influence in young adults who use recreational drugs. To better understand whether the neural and/or behavioral response to social influence differs in young adults using illicit drugs, 20 marijuana-using young adults (MJ) aged 18-25, and 20 controls (CON) performed a decision-making task in the context of social influence, while they underwent functional magnetic resonance imaging scans. A priori analyses focused on the nucleus accumbens (NAc), with post hoc analyses in the rest of the striatum. In this task, participants could choose to either follow or go against group influence. When subjects applied social information to response choice selection (independent of following or going against group influence), we observed activation in the middle striatum (caudate), in the MJ group only, that extended ventrally into the NAc. MJ users but not CON showed greater activation in the NAc but not the caudate while making choices congruent with group influence as opposed to choices going against group influence. Activation in the NAc when following social influence was associated with amount of drug use reported. In contrast, during the feedback phase of the task we observed significant NAc activation in both MJ and CON, along with dorsal caudate activation only in MJ participants. This NAc activation did not correlate with drug use. This study shows that MJ users, but not CON, show differential brain activation across striatal subregions when applying social information to make a decision, following versus going against a group of peers, or receiving positive feedback. The current work suggests that differential neural sensitivity to social influence in regions such as the striatum may contribute to the development and/or maintenance of marijuana use.

  15. The Influence of Climacteric Symptoms on Women’s Lives and Activities

    Directory of Open Access Journals (Sweden)

    Agnieszka Bień

    2015-04-01

    Full Text Available In the present study, we performed an analysis of the influence of climacteric symptoms on women’s lives and activities, i.e. their quality of life (QoL. The study was performed between October 2011 and February 2012. It included 148 women aged 44–62. The study used a diagnostic survey with questionnaires. The research instrument was the Blatt-Kupperman index. The respondents were asked to complete a questionnaire on socio-demographic data, quality of life, and the influence of climacteric symptoms on life and its various aspects. The respondents experiencing moderate or severe climacteric symptoms also had stronger feelings of failure (p = 0.005, feeling that opportunities are still available (p = 0.002, of losing their youth and beauty (p < 0.0001, compared to those who had slight or no symptoms. The intensity of climacteric symptoms significantly affects women’s lives and activities, i.e., their QoL. The reported intensity of climacteric symptoms is influenced by the respondents’ education, residence, marital status and professional activity. The more severe the climacteric symptoms, the lower the women’s quality of life, as evidenced for example by the feeling of failure and of losing one’s youth, beauty and opportunities.

  16. Influence of the day care, home and neighbourhood environment on young children's physical activity and health

    DEFF Research Database (Denmark)

    Christian, Hayley; Maitland, Clover; Enkel, Stephanie

    2016-01-01

    to determine outdoor location of physical activity around the home and neighbourhood for a subsample (n=310). The day care environment will be objectively measured using a validated audit tool. Other potential individual, social and physical environmental influences on preschoolers' physical activity...... such as long day care. Research is required to determine how the design of day care outdoor (and indoor) spaces provides opportunities or constraints for physical activity. A significant evidence gap surrounds what objectively measured attributes of the home and neighbourhood environment influence preschoolers......' physical activity. The PLAY Spaces & Environments for Children's Physical Activity (PLAYCE) study will empirically investigate the relative and cumulative influence of the day care, home and neighbourhood environment on preschoolers' physical activity. METHODS AND ANALYSIS: The PLAYCE study is a cross...

  17. Research data management and libraries: relationships, activities, drivers and influences.

    Directory of Open Access Journals (Sweden)

    Stephen Pinfield

    Full Text Available The management of research data is now a major challenge for research organisations. Vast quantities of born-digital data are being produced in a wide variety of forms at a rapid rate in universities. This paper analyses the contribution of academic libraries to research data management (RDM in the wider institutional context. In particular it: examines the roles and relationships involved in RDM, identifies the main components of an RDM programme, evaluates the major drivers for RDM activities, and analyses the key factors influencing the shape of RDM developments. The study is written from the perspective of library professionals, analysing data from 26 semi-structured interviews of library staff from different UK institutions. This is an early qualitative contribution to the topic complementing existing quantitative and case study approaches. Results show that although libraries are playing a significant role in RDM, there is uncertainty and variation in the relationship with other stakeholders such as IT services and research support offices. Current emphases in RDM programmes are on developments of policies and guidelines, with some early work on technology infrastructures and support services. Drivers for developments include storage, security, quality, compliance, preservation, and sharing with libraries associated most closely with the last three. The paper also highlights a 'jurisdictional' driver in which libraries are claiming a role in this space. A wide range of factors, including governance, resourcing and skills, are identified as influencing ongoing developments. From the analysis, a model is constructed designed to capture the main aspects of an institutional RDM programme. This model helps to clarify the different issues involved in RDM, identifying layers of activity, multiple stakeholders and drivers, and a large number of factors influencing the implementation of any initiative. Institutions may usefully benchmark their

  18. Research data management and libraries: relationships, activities, drivers and influences.

    Science.gov (United States)

    Pinfield, Stephen; Cox, Andrew M; Smith, Jen

    2014-01-01

    The management of research data is now a major challenge for research organisations. Vast quantities of born-digital data are being produced in a wide variety of forms at a rapid rate in universities. This paper analyses the contribution of academic libraries to research data management (RDM) in the wider institutional context. In particular it: examines the roles and relationships involved in RDM, identifies the main components of an RDM programme, evaluates the major drivers for RDM activities, and analyses the key factors influencing the shape of RDM developments. The study is written from the perspective of library professionals, analysing data from 26 semi-structured interviews of library staff from different UK institutions. This is an early qualitative contribution to the topic complementing existing quantitative and case study approaches. Results show that although libraries are playing a significant role in RDM, there is uncertainty and variation in the relationship with other stakeholders such as IT services and research support offices. Current emphases in RDM programmes are on developments of policies and guidelines, with some early work on technology infrastructures and support services. Drivers for developments include storage, security, quality, compliance, preservation, and sharing with libraries associated most closely with the last three. The paper also highlights a 'jurisdictional' driver in which libraries are claiming a role in this space. A wide range of factors, including governance, resourcing and skills, are identified as influencing ongoing developments. From the analysis, a model is constructed designed to capture the main aspects of an institutional RDM programme. This model helps to clarify the different issues involved in RDM, identifying layers of activity, multiple stakeholders and drivers, and a large number of factors influencing the implementation of any initiative. Institutions may usefully benchmark their activities against the

  19. Familial influences on the full range of variability in attention and activity levels during adolescence: A longitudinal twin study.

    Science.gov (United States)

    Peng, Chun-Zi; Grant, Julia D; Heath, Andrew C; Reiersen, Angela M; Mulligan, Richard C; Anokhin, Andrey P

    2016-05-01

    To investigate familial influences on the full range of variability in attention and activity across adolescence, we collected maternal ratings of 339 twin pairs at ages 12, 14, and 16, and estimated the transmitted and new familial influences on attention and activity as measured by the Strengths and Weaknesses of Attention-Deficit/Hyperactivity Disorder Symptoms and Normal Behavior Scale. Familial influences were substantial for both traits across adolescence: genetic influences accounted for 54%-73% (attention) and 31%-73% (activity) of the total variance, and shared environmental influences accounted for 0%-22% of the attention variance and 13%-57% of the activity variance. The longitudinal stability of individual differences in attention and activity was largely accounted for by familial influences transmitted from previous ages. Innovations over adolescence were also partially attributable to familial influences. Studying the full range of variability in attention and activity may facilitate our understanding of attention-deficit/hyperactivity disorder's etiology and intervention.

  20. Role of Diet in Influencing Rheumatoid Arthritis Disease Activity

    Science.gov (United States)

    Badsha, Humeira

    2018-01-01

    Background: Patients with Rheumatoid Arthritis (RA) frequently ask their doctors about which diets to follow, and even in the absence of advice from their physicians, many patients are undertaking various dietary interventions. Discussion: However, the role of dietary modifications in RA is not well understood. Several studies have tried to address these gaps in our understanding. Intestinal microbial modifications are being studied for the prevention and management of RA. Some benefits of vegan diet may be explained by antioxidant constituents, lactobacilli and fibre, and by potential changes in intestinal flora. Similarly, Mediterranean diet shows anti-inflammatory effects due to protective properties of omega-3 polyunsaturated fatty acids and vitamins, but also by influencing the gut microbiome. Gluten-free and elemental diets have been associated with some benefits in RA though the existing evidence is limited. Long-term intake of fish and other sources of long-chain polyunsaturated fatty acids are protective for development of RA. The benefits of fasting, anti-oxidant supplementation, flavanoids, and probiotics in RA are not clear. Vitamin D has been shown to influence autoimmunity and specifically decrease RA disease activity. The role of supplements such as fish oils and vitamin D should be explored in future trials to gain new insights in disease pathogenesis and develop RA-specific dietary recommendations. Conclusion: Specifically more research is needed to explore the association of diet and the gut microbiome and how this can influence RA disease activity. PMID:29515679

  1. MRI grading method for active and chronic spinal changes in spondyloarthritis

    International Nuclear Information System (INIS)

    Madsen, K.B.; Jurik, A.G.

    2010-01-01

    Aim: To describe a magnetic resonance imaging (MRI) grading method for both active and chronic spondyloarthritis (SpA) changes in the spine, to test its validity, and compare chronic MRI scores with findings obtained by radiography. Material and methods: A total of 91 patients (41 males; 50 females) with back pain fulfilling the European Spondylarthropathy Study Group (ESSG) criteria for SpA were examined using MRI and radiography of the spine. The mean age was 36.7 years (range 16-51 years) and symptom duration was between 3 and 27 years. The MRI images were assessed for signs of disease activity (bone marrow oedema at the vertebral plates and costo-vertebral joints) and chronic structural changes [syndesmophytes/vertebral fusion, erosion, and fatty marrow deposition (FMD)]. The interobserver agreement was analysed based on 37 examinations. Radiographs were assessed for the presence of shiny corners, vertebral squaring, syndesmophytes/fusion, and erosion. Results: The interobserver agreement for the assessed MRI abnormalities was acceptable, with kappa values between 0.62 and 0.77. A total of 56 patients had SpA-related spinal abnormalities as depicted using MRI. The total chronic MRI score was not significantly related to the radiographic score, mainly because syndesmophytes were difficult to detect by MRI and FMD was only visualized by MRI. However, FMD was significantly related to the total radiographic score and vertebral squaring. Conclusion: The described MRI grading method was reliable for assessing both disease activity and chronic changes. MRI is promising for estimating chronic changes, but cervical radiography may still be needed. FMD seems to be an important sign of chronicity.

  2. MRI grading method for active and chronic spinal changes in spondyloarthritis

    Energy Technology Data Exchange (ETDEWEB)

    Madsen, K.B. [Department of Radiology, Aarhus University Hospital, Aarhus Sygehus (Denmark); Jurik, A.G., E-mail: anne.jurik@aarhus.rm.d [Department of Radiology, Aarhus University Hospital, Aarhus Sygehus (Denmark)

    2010-01-15

    Aim: To describe a magnetic resonance imaging (MRI) grading method for both active and chronic spondyloarthritis (SpA) changes in the spine, to test its validity, and compare chronic MRI scores with findings obtained by radiography. Material and methods: A total of 91 patients (41 males; 50 females) with back pain fulfilling the European Spondylarthropathy Study Group (ESSG) criteria for SpA were examined using MRI and radiography of the spine. The mean age was 36.7 years (range 16-51 years) and symptom duration was between 3 and 27 years. The MRI images were assessed for signs of disease activity (bone marrow oedema at the vertebral plates and costo-vertebral joints) and chronic structural changes [syndesmophytes/vertebral fusion, erosion, and fatty marrow deposition (FMD)]. The interobserver agreement was analysed based on 37 examinations. Radiographs were assessed for the presence of shiny corners, vertebral squaring, syndesmophytes/fusion, and erosion. Results: The interobserver agreement for the assessed MRI abnormalities was acceptable, with kappa values between 0.62 and 0.77. A total of 56 patients had SpA-related spinal abnormalities as depicted using MRI. The total chronic MRI score was not significantly related to the radiographic score, mainly because syndesmophytes were difficult to detect by MRI and FMD was only visualized by MRI. However, FMD was significantly related to the total radiographic score and vertebral squaring. Conclusion: The described MRI grading method was reliable for assessing both disease activity and chronic changes. MRI is promising for estimating chronic changes, but cervical radiography may still be needed. FMD seems to be an important sign of chronicity.

  3. Ion Tentiuc, Contribuţii la istoria şi arheologia spaţiului pruto-nistrean. Siturile de la Durleşti şi Moleşti, Biblioteca Tyragetia, XXI (Chișinău: Muzeul Naţional de Istorie a Moldovei, 2012

    Directory of Open Access Journals (Sweden)

    Sergiu Musteata

    2013-12-01

    Full Text Available Review on book - Ion Tentiuc, Contribuţii la istoria şi arheologia spaţiului pruto-nistrean. Siturile de la Durleşti şi Moleşti, Biblioteca Tyragetia, XXI (Chișinău: Muzeul Naţional de Istorie a Moldovei, 2012

  4. Giving children a voice: Exploring qualitative perspectives on factors influencing recess physical activity

    DEFF Research Database (Denmark)

    Pawlowski, Charlotte Skau; Schipperijn, Jasper; Tjørnhøj-Thomsen, Tine

    2018-01-01

    Facilitators and barriers to recess physical activity are not well understood. To date, research on recess physical activity has predominantly focused on quantitative measures typically focusing on a narrow set of predefined factors, often constructed by adults. To really understand the factors...... 11–12-year-old children. The socio-ecological model was used as the overall theoretical framework. Twelve factors were identified as influencing the children’s recess physical activity: bodily self-esteem and ability; gender; gendered school culture; peer influence; conflicts and exclusion; space...... and place experiences; lack of play facilities; outdoor play policy; use of electronic devices; recess duration; organised activities; and weather. These factors were located within different layers of the socio-ecological model, but were interdependent. The findings speak for implementing a combination...

  5. Environmental influences on physical activity in rural Midwestern adults: a qualitative approach.

    Science.gov (United States)

    Chrisman, Matthew; Nothwehr, Faryle; Yang, Ginger; Oleson, Jacob

    2015-01-01

    Qualitative research can be used to examine multiple factors associated with physical activity and help practitioners identify language used by the rural adult population when discussing this behavior. Three focus groups were conducted among 19 residents of multiple towns in a rural Midwestern county to examine the language and influences on rural physical activity. Focus group members were asked to define physical activity, exercise, community, and neighborhood. They were asked about the activities they engaged in and facilitators and barriers to those activities. A guidebook was developed to capture major themes and common patterns that emerged in the responses to the topics discussed. The data were reviewed for repeated statements and points that were agreed on by multiple participants. Important factors associated with physical activity include the importance of social support and modeling physical activity behavior. Also, the influence of pets and children was important for engaging these adults in physical activity. The focus group members engaged in walking and bicycling in their neighborhood streets and community trails, and desired to see community buildings be open to the public for exercise. This study revealed contextual issues and culturally relevant language for practitioners to use in tailoring physical activity measurement tools or designing interventions for a rural adult population. Social support (specifically, seeing others being active and using pets as motivators for being active) and policy attitudes may be targeted for interventions to increase physical activity in rural adults. © 2014 Society for Public Health Education.

  6. ANALYSIS OF THE EXTERNAL FACTORS OF INFLUENCE ON INNOVATION ACTIVITY OF AN INDUSTRIAL ENTERPRISE

    Directory of Open Access Journals (Sweden)

    I. A. Salikov

    2014-01-01

    Full Text Available Summary. For successful functioning and development of the enterprise is a need to strive as possible deeper and more dynamic influence on parameters and objects OK-environmental management, primarily due to increase their innovation activity. Innovative activity of enterprises influenced by many factors. They can be classified on the factors of direct influence (micro and factors of indirect impacts (macro. Factors of direct impact of the influence on the pace and scale of development of the enterprise, on its effectiveness, because the whole spectrum of these factors acts as a limiter. Macro factors create the General conditions of existence of the enterprise in the external environment. To analyses these factors approach was used to SNW-analysis. As a result of analysis, factors of micro and macro-were classified on: stimulating, it minesweepers and dissuasive. Also studied were the degree of influence of these factors on the innovative activity of the enterprise. Reviewed rating factors hindering the development of innovation activity of industrial enterprise in Russia. In the result of which identified factors that hinder the development of innovative activity, and justified in the direction of overcoming them. It should be noted that the distinction between enabling and constraining factors is rather thin and conditional. So, the factors initially restraining innovation, at a certain point can be transformed into a stimulus for its development. Accounting for these factors, creation of necessary conditions and introduction of innovations in various aspects of the functioning of industrial enterprises will allow them to provide competitor-term benefits and sustainable development in a rapidly changing environment and the external environment.

  7. Separating active and passive influences on stomatal control of transpiration.

    Science.gov (United States)

    McAdam, Scott A M; Brodribb, Timothy J

    2014-04-01

    Motivated by studies suggesting that the stomata of ferns and lycophytes do not conform to the standard active abscisic acid (ABA) -mediated stomatal control model, we examined stomatal behavior in a conifer species (Metasequoia glyptostroboides) that is phylogenetically midway between the fern and angiosperm clades. Similar to ferns, daytime stomatal closure in response to moderate water stress seemed to be a passive hydraulic process in M. glyptostroboides immediately alleviated by rehydrating excised shoots. Only after prolonged exposure to more extreme water stress did active ABA-mediated stomatal closure become important, because foliar ABA production was triggered after leaf turgor loss. The influence of foliar ABA on stomatal conductance and stomatal aperture was highly predictable and additive with the passive hydraulic influence. M. glyptostroboides thus occupies a stomatal behavior type intermediate between the passively controlled ferns and the characteristic ABA-dependent stomatal closure described in angiosperm herbs. These results highlight the importance of considering phylogeny as a major determinant of stomatal behavior.

  8. [The spa and health resort-based treatment of metabolic syndrome with the application of the therapeutic courses of different duration: the evaluation according long-term results].

    Science.gov (United States)

    Chalaya, E N; Botvineva, L A; Tsallagova, L V; Ahkubekova, N K; Efimenko, N V; Kaysinova, A S; Amiyants, V Yu; Vasin, V A

    The objective of the present study was to estimate the effectiveness of the new therapeutic modalities for the spa and health resort-based treatment of metabolic syndrome based on the results of the long-term follow-up observations. A total of 100 patients presenting with metabolic syndrome were recruited for the participation in the study. All of them underwent a shortened course of mineral water intake in the combination with the use of the herbal medicinal products. The results of the study give evidence of the more favorable changes in the clinical and instrumental characteristics of the patients with metabolic syndrome treated with the use of the proposed approach in comparison the patients treated by the conventional methods. Moreover, the beneficial effects of the proposed approach persisted during a longer period. The basal treatment given to our patients was supplemented by dietary therapy, therapeutic physical exercise, narzan baths, intake of mineral water having a temperature of 35-37 °С in conjunction with sulphate mineral water (narzan) cooled to 13-15 °С, and a phytococktail. The results of the long-term observations confirmed the enhanced effectiveness of the spa and health resort-based treatment of metabolic syndrome including the therapeutic courses with the intake of cooled narzan mineral water in the combination with phytococktails. This therapeutic modality increased the duration of the favorable changes of various parameters that characterize metabolic syndrome. Specifically, they persisted during 5-6 months after the application of the standard methods, were still apparent within 6-7 months after the two-week course of the treatment with cold narzan and phytococktails, and during 8-9 months when the duration of the treatment course was extended up to 3 weeks.

  9. Influence of cure activator on the structure and properties of rubbers

    Directory of Open Access Journals (Sweden)

    O. V. Karmanova

    2013-01-01

    Full Text Available The influence of vulcanization activator type on the properties of the compositions and elastic-strength characteristics of rubber was studied. Found that the modification of zinc oxide as the basis of actual formation curing vulcanization agents leads to an increase of vulcanization active centers, providing an increase in the velocity of rubber vulcanization and improvement of physical and mechanical rubber’s properties.

  10. Influence of healthcare institution managers' proactive approach to communication activities on patient satisfaction

    Directory of Open Access Journals (Sweden)

    Filipović Vinka

    2010-01-01

    Full Text Available Background/Aim. Over the recent years customer satisfaction program as a tool for patient satisfaction has been recognized as an important issue in healthcare services. The aim of this preliminary study was to explore an influence of healthcare institution managers' approach and attitudes to marketing and public relations activities (communication activities, in the context of implementation of customer satisfaction programs, on patient satisfaction. Methods. The study was conducted among managers from different state-owned healthcare institutions (healthcare centers, clinics, hospitals in Serbia. The structured questionnaire form, comprising both open and closed questions, was used as a main research tool. The total number of sent questionnaires was 120; 56 questionnaires were sent back, while 49 of them were valid. Results. It was shown that 42.9% of healthcare institutions apply proactive media approach, and that 35.7% of the organizations have a person who, besides his/her basic engagements, performs activities connected with marketing and public relations. Using Chi-square likelihood ratio test it is confirmed that these activities have a significant role in supporting customer satisfaction program implementation (p < 0.05. The results showed that in 69.4% cases, positive attitude of healthcare institutions managers toward marketing and public relations activities had positive influence on patient satisfaction (p < 0.05. Conclusion. Managers in healthcare sector in Serbia who used proactive approach toward media and who had already institutionalized communication activities with external stakeholders have a positive attitude to implementation of customer satisfaction program. Furthermore, managers' attitude toward communication activities has influence on patient satisfaction.

  11. GPR Activities in Italy: a Review

    Science.gov (United States)

    Tosti, Fabio; Ambrosanio, Michele; Battaglia, Enzo; Bianchini Ciampoli, Luca; De Carlo, Lorenzo; Matera, Loredana; Prontera, Santo; Sileo, Maria

    2015-04-01

    Ground-penetrating radar has been increasingly played an important role over the last 15 years in Italy due to its high reliability in assisting the assessment of the built environment for civil engineering purposes, and in being used for geophysical investigations within many other fields of application. In line with this, original works involving fundamental aspects of this technique and implementing its use more practically in a number of interesting projects have been developed over years, both under a research and an enterprise point of view. This paper will endeavour to review the current status of ground-penetrating radar activities in Italy. Efforts have been devoted to single out the most interesting national research projects, both recent and ongoing, involving ground-penetrating radar in Italy, such as the ARCHEO project in the 90s, funded by the Italian Ministry for Universities, wherein a stepped frequency ultra-wide band radar suited for archaeological surveys was manufactured. In this framework, it is worth citing another important and more recent project, European Community funded, namely, ORFEUS, which started in the late 2006 with the overall aim of providing the capability to locate buried infrastructure accurately and reliably by means of a bore-head ground-penetrating radar for horizontal directional drilling. A review on the main use of this non-destructive technique in management activities of national resources and infrastructures has been also performed, ranging from the applications made by Anas S.p.A., i.e., the main management authority for the Italian road and motorway network, up to private enterprises specialized in both services providing and ground-penetrating radar manufacturing such as, to cite a few, Sineco S.p.A. and IDS Ingegneria dei Sistemi S.p.A., respectively. Current national guidelines, rules or protocols to be followed during radar surveys have been also reviewed. Unlike well-established international standards such as

  12. Influence Determination of Social Responsibility to the Productivity Enterprise Activity Level

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    Sergii Kavun

    2016-07-01

    Full Text Available The purpose of this paper is to develop a scientific and methodical approach for determination of the comprehensive social responsibility indicator in this paper based on estimation of influence degree for the economical, ecological, social and labour, standard and legal components. There is allowance for determining of some level of enterprise social responsibility. In addition, there is a basis for development some ways of their increasing. The essence of the used approach is clotting of the individual indicators set to four intermediate indicators of the economic, ecological, social and labor, standard and legal components, which can be boiled down to the generalizing activity productivity indicator based on the matrix and range approach. An economical and mathematical model of the social responsibility influence level to the enterprise activity productivity level, which is based on enterprise propose harmonization with the participants’ interests, was being built. The paper proposes the mathematical model, which allows detecting a necessary time period for enterprise activity productivity ensuring due to social responsibility implementation.

  13. The influence of business strategy on new product activity: the role of market orientation

    NARCIS (Netherlands)

    Frambach, R.T.; Prabhu, Jaideep; Verhallen, T.M.M.

    2003-01-01

    In this paper, we propose that business strategy influences new product activity both directly and indirectly via its influence on market orientation. Accordingly, we develop a framework linking firms' relative emphasis on cost leadership, product differentiation and focus strategies to firms'

  14. Methicillin-resistant Staphylococcus aureus isolates with SCCmec type V and spa types t437 or t1081 associated to discordant susceptibility results between oxacillin and cefoxitin, Central Taiwan.

    Science.gov (United States)

    Ho, Cheng-Mao; Lin, Chien-Yu; Ho, Mao-Wang; Lin, Hsiao-Chuan; Chen, Chao-Jung; Lin, Lee-Chung; Lu, Jang-Jih

    2016-12-01

    Staphylococcus aureus isolates with discordant susceptibility results between oxacillin and cefoxitin obtained using automated microbiology systems are infrequently observed. From April 2013 to December 2014, 1956 methicillin-resistant S. aureus (MRSA) and 1761 methicillin-susceptible S. aureus isolates were obtained from different patients. Forty isolates (1.1% and 2% in case of S. aureus and MRSA, respectively) with discordant susceptibility results (oxacillin susceptible and cefoxitin resistant) and carrying mecA gene were obtained. Except 2 SCCmec type IV isolates, 38 MRSA isolates were all SCCmec type V (V T or non-V T ), which were further divided into V T (n=22) and non-V T (n=16). The most common spa type in V T and non-V T isolates were t437 (n=19) and t1081 (n=13), respectively. Only 55% of patients received effective antimicrobial agents; 2 mortalities were not attributable to MRSA infection. Using standard agar dilution, 17 MRSA isolates (0.46% and 0.87% in case of S. aureus and MRSA, respectively) had oxacillin MIC in the susceptible ranges (oxacillin-susceptible MRSA [OS-MRSA]); all carried SCCmec type V (V T , n=8; non-V T , n=9). The most common spa-MLST types of OS-MRSA in V T and non-V T were t437-ST59 (n=4) and t1081-ST45 (n=7), respectively. Concomitant testing by both cefoxitin- and oxacillin-based methods is a practical strategy for OS-MRSA detection in the clinical laboratories. Continuous monitoring of OS-MRSA isolates is necessary to elucidate their impact in clinical infectious diseases. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. The Influence of Solar Activity on the Rainfall over India: Cycle-to ...

    Indian Academy of Sciences (India)

    The Influence of Solar Activity on the Rainfall over India: Cycle-to-Cycle Variations. K. M. Hiremath. Indian Institute of Astrophysics, Bangalore 560 034, India. e-mail: hiremath@iiap.res.in. Abstract. We use 130 years data for studying correlative effects due to solar cycle and activity phenomena on the occurrence of rainfall ...

  16. Áreas (desprotegidas do Brasil: as estâncias hidrominerais Protected areas in Brazil: Brazilian spa towns

    Directory of Open Access Journals (Sweden)

    Alessandra Bortoni Ninis

    2008-06-01

    Full Text Available Resumo: O presente texto discute a vulnerabilidade das estâncias hidrominerais brasileiras frente à expansão do mercado de águas minerais engarrafadas. Mostra como o isolamento entre as estâncias e as suas águas minerais, de um lado, e as políticas brasileiras de preservação ambiental, como a Política Nacional de Recursos Hídricos e a política de unidades de conservação, coloca em risco a sustentabilidade da produção hídrica, o turismo e os padrões de vida das comunidades residentes nestas estâncias.Abstract: The present paper discusses the vulnerability of Brazilian spa towns that depend on the extraction of mineral water, given the expansion of the market for bottled mineral water. It shows how the isolation of these communities and their sources of mineral water, on the one side, and the Brazilian environmental preservation policies (like the National Water Policy and the Conservation Units Policy, on the other, place risks to the sustainability of water production, to tourism and to the standards of living achieved by the communities depending on the extraction of mineral water.

  17. Physical activity in adolescents: analysis of social influence of parents and friends

    Directory of Open Access Journals (Sweden)

    Luanna Alexandra Cheng

    2014-01-01

    Conclusions: Parents and friends have a social influence on adolescents’ level of physical activity through the mechanism of behavior modeling or through social support, mediated by self‐efficacy.

  18. Physical activity, evaluation of menopause, life satisfaction and influence tactics in marriage of perimenopausal women

    Directory of Open Access Journals (Sweden)

    Eugenia Mandal

    2016-10-01

    Full Text Available Background Domination of the biomedical approach to menopause may imply creation of negative attitudes to the phenomenon, and at the same time negatively affect women’s life satisfaction and behaviour in the family. It is assumed that physical activity may be a defensive factor, as this type of activity may reduce the intensity of menopause symptoms. The aim of the research was to determine the relation between menopause evaluation, life satisfaction and tactics of influence employed in marriage by women who differ in involvement in physical exercise. Participants and procedure The research was conducted among 90 women, at the age of 45-55: 45 physically active women and 45 women who do not engage in any physical activity. The following research methods were used: the Menopause Evaluation Scale, the Satisfaction With Life Scale (SWLS and the Questionnaire of Influence in Close Relations of Women and Men. Results Positive evaluation of menopause was related to involvement in physical exercise as well as to a stronger tendency to use positive strategies of exerting influence on one’s spouse. The research also showed a slight correlation between life satisfaction and involvement in physical exercise. Negative evaluation of menopause was related to avoiding physical activity. Conclusions Physical activity is more frequently related to a positive attitude towards menopause and the use of more positive tactics of exerting influence on one’s spouse, and slightly positively conducive to one’s life satisfaction level.

  19. Prefrontal θ-Burst Stimulation Disrupts the Organizing Influence of Active Short-Term Retrieval on Episodic Memory.

    Science.gov (United States)

    Marin, Bianca M; VanHaerents, Stephen A; Voss, Joel L; Bridge, Donna J

    2018-01-01

    Dorsolateral prefrontal cortex (DLPFC) is thought to organize items in working memory and this organizational role may also influence long-term memory. To causally test this hypothesized role of DLPFC in long-term memory formation, we used θ-burst noninvasive stimulation (TBS) to modulate DLPFC involvement in a memory task that assessed the influence of active short-term retrieval on later memory. Human subjects viewed three objects on a grid and then either actively retrieved or passively restudied one object's location after a brief delay. Long-term memory for the other objects was assessed after a delay to evaluate the beneficial role of active short-term retrieval on subsequent memory for the entire set of object locations. We found that DLPFC TBS had no significant effects on short-term memory. In contrast, DLPFC TBS impaired long-term memory selectively in the active-retrieval condition but not in the passive-restudy condition. These findings are consistent with the hypothesized contribution of DLPFC to the organizational processes operative during active short-term retrieval that influence long-term memory, although other regions that were not stimulated could provide similar contributions. Notably, active-retrieval and passive-restudy conditions were intermixed, and therefore nonspecific influences of stimulation were well controlled. These results suggest that DLPFC is causally involved in organizing event information during active retrieval to support coherent long-term memory formation.

  20. In vitro reconstitution of sortase-catalyzed pilus polymerization reveals structural elements involved in pilin cross-linking.

    Science.gov (United States)

    Chang, Chungyu; Amer, Brendan R; Osipiuk, Jerzy; McConnell, Scott A; Huang, I-Hsiu; Hsieh, Van; Fu, Janine; Nguyen, Hong H; Muroski, John; Flores, Erika; Ogorzalek Loo, Rachel R; Loo, Joseph A; Putkey, John A; Joachimiak, Andrzej; Das, Asis; Clubb, Robert T; Ton-That, Hung

    2018-06-12

    Covalently cross-linked pilus polymers displayed on the cell surface of Gram-positive bacteria are assembled by class C sortase enzymes. These pilus-specific transpeptidases located on the bacterial membrane catalyze a two-step protein ligation reaction, first cleaving the LPXTG motif of one pilin protomer to form an acyl-enzyme intermediate and then joining the terminal Thr to the nucleophilic Lys residue residing within the pilin motif of another pilin protomer. To date, the determinants of class C enzymes that uniquely enable them to construct pili remain unknown. Here, informed by high-resolution crystal structures of corynebacterial pilus-specific sortase (SrtA) and utilizing a structural variant of the enzyme (SrtA 2M ), whose catalytic pocket has been unmasked by activating mutations, we successfully reconstituted in vitro polymerization of the cognate major pilin (SpaA). Mass spectrometry, electron microscopy, and biochemical experiments authenticated that SrtA 2M synthesizes pilus fibers with correct Lys-Thr isopeptide bonds linking individual pilins via a thioacyl intermediate. Structural modeling of the SpaA-SrtA-SpaA polymerization intermediate depicts SrtA 2M sandwiched between the N- and C-terminal domains of SpaA harboring the reactive pilin and LPXTG motifs, respectively. Remarkably, the model uncovered a conserved TP(Y/L)XIN(S/T)H signature sequence following the catalytic Cys, in which the alanine substitutions abrogated cross-linking activity but not cleavage of LPXTG. These insights and our evidence that SrtA 2M can terminate pilus polymerization by joining the terminal pilin SpaB to SpaA and catalyze ligation of isolated SpaA domains in vitro provide a facile and versatile platform for protein engineering and bio-conjugation that has major implications for biotechnology.

  1. The influence of human physical activity and contaminated clothing type on particle resuspension.

    Science.gov (United States)

    McDonagh, A; Byrne, M A

    2014-01-01

    A study was conducted to experimentally quantify the influence of three variables on the level of resuspension of hazardous aerosol particles from clothing. Variables investigated include physical activity level (two levels, low and high), surface type (four different clothing material types), and time i.e. the rate at which particles resuspend. A mixture of three monodisperse tracer-labelled powders, with median diameters of 3, 5, and 10 microns, was used to "contaminate" the samples, and the resuspended particles were analysed in real-time using an Aerodynamic Particle Sizer (APS), and also by Neutron Activation Analysis (NAA). The overall finding was that physical activity resulted in up to 67% of the contamination deposited on clothing being resuspended back into the air. A detailed examination of the influence of physical activity level on resuspension, from NAA, revealed that the average resuspended fraction (RF) of particles at low physical activity was 28 ± 8%, and at high physical activity was 30 ± 7%, while the APS data revealed a tenfold increase in the cumulative mass of airborne particles during high physical activity in comparison to that during low physical activity. The results also suggest that it is not the contaminated clothing's fibre type which influences particle resuspension, but the material's weave pattern (and hence the material's surface texture). Investigation of the time variation in resuspended particle concentrations indicated that the data were separable into two distinct regimes: the first (occurring within the first 1.5 min) having a high, positive rate of change of airborne particle concentration relative to the second regime. The second regime revealed a slower rate of change of particle concentration and remained relatively unchanged for the remainder of each resuspension event. Copyright © 2013 Elsevier Ltd. All rights reserved.

  2. Post-Materialism as a Cultural Factor Influencing Entrepreneurial Activity across Nations

    OpenAIRE

    Uhlaner, L.M.; Thurik, A.R.; Hutjes, J.

    2002-01-01

    textabstractThe study of the determinants of entrepreneurship at the country level has been dominated by economic influences. The relative stability of differences in levels of entrepreneurship across coun-tries suggests that other forces such as certain institutional and/or cultural factors are at play. The objective of this paper is to explore how post-materialism explains differences in entrepreneurial activity across countries. Entrepreneurial activity is defined as the percent of a count...

  3. Perceived difficulties using everyday technology after acquired brain injury: influence on activity and participation.

    Science.gov (United States)

    Lindén, Anita; Lexell, Jan; Lund, Maria Larsson

    2010-12-01

    Using everyday technology (ET) is a prerequisite for activities and participation at home and in the community. It is well known that persons with an acquired brain injury (ABI) can have limitations in activities of daily living but our knowledge of their difficulties using ET is not known. Thirty-six persons (27 men and 9 women, mean age 44 years, age range 26-60) with an ABI (2-10 years post injury) were interviewed, using the Everyday Technology Use Questionnaire (ETUQ), about their perceived difficulties using ET and how these difficulties influenced their everyday activities and their possibilities to participate at home and in the community. A majority (78%) of the persons reported difficulties using ET. The most common difficulties were related to the use of telecommunication and computers. Despite these difficulties, a majority still used most objects and services independently. Twenty-six participants (72%) perceived that their difficulties using ET influenced their everyday activities and their possibility to participate at home and in the community. The results indicate that rehabilitation following an ABI should consider whether clients' use of ET influences their activity and participation and adopt interventions accordingly. The results also indicate that difficulties using ET need to be considered in the design of community services to prevent societal barriers.

  4. Elementary Schoolchildren's Perceived Competence and Physical Activity Involvement: The Influence of Parents' Role Modelling Behaviours and Perceptions of their Child's Competence

    OpenAIRE

    Bois, Julien; Sarrazin, Philippe; Brustad, Robert; Trouilloud, David; Cury, François

    2005-01-01

    International audience; Objectives. To study the influence of fathers' and mothers' physical activity involvement and perceptions of their children's physical competence upon children's perceptions of competence and children's time spent in physical activity. Two forms of parental socialization influence were assessed: the direct influence of parents' actual physical activity (PA) behaviour (role modelling) on children's physical activity and the indirect influence of parents' beliefs systems...

  5. Influence of coal preoxidation on the porosity of the activated carbons with steam activation

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Yuwen; Gao, Jihui; Sun, Fei; Li, Yang; Wu, Shaohua; Qin, Yukun [Harbin Institute of Technology, Harbin (China). School of Energy Science and Engineering

    2013-07-01

    Activated carbons have been prepared from a low ash content anthracite preoxidized in air to different degrees. Steam has been used as activating agent to prepare different burn-off samples. The preoxidation effect on the physico-chemical characteristics of the resulting chars and activated carbons were comparatively studied. The surface area and porosity of sample was studied by N{sub 2} adsorption at 77 0A0;K. The results show that introduced oxygen in coal structure had a great influence on the carbonization and subsequent activation process. The carbonization of oxidized coal exhibited a broader volatile evolution with respect to temperature, and the resulting chars had a larger microporosity. The porosity of the char is a primary foundation to develop more microporosity upon activation. Activation of char from oxidized coal facilitated development of small scale micropore, however, the micropore widening was also observed at high burn-offs. Compared with development of supermicropore, the evolution of mesoporosity is hindered strongly by preoxidation treatment. The quantity of basic surface sites in activated carbons increased with an increase in oxidation degree, while the quantity of acidic sites appeared equivalent. It seemed that the amount of surface groups and the microporosity mainly developed in a parallel way.

  6. EFFECT OF KINESIO TAPE VERSUS ATHLETIC TAPE ON MYOELECTRIC ACTIVITY OF ANKLE MUSCLES IN PATIENTS WITH CHRONIC ANKLE SPRAIN

    Directory of Open Access Journals (Sweden)

    Asmaa F Abdelmonem

    2018-04-01

    Full Text Available Background: Sprained ankle a common orthopedic injury. The standard treatment for ankle sprains remains nonoperative. Ankle taping was used to protect and prevent ligaments excessive strain. So, the current study aimed at investigating the effect of spa-care Kinesio tape versus standard white athletic tape on myoelectric activities (EMG of ankle evertors (peroneus longus and invertors (tibialis anterior in a chronic ankle sprain. Methods: A convenient sample of 30 patients with a chronic ankle sprain (18 females and 12 males were included in this study. Their mean age ±SD was 24 ±1.2 years. Their height was 175±4.8 cm among men & 163±5.2 cm for females, and weight was 85±5.2 kg for males & 74±5.5 kg for women. It was a within-group design in which the same participant experienced the two types of taping compared to no taping condition. Root mean square (RMS was measured while participants were moving the isokinetic dynamometer at an angular velocity of 120°/sec using concentric contraction mode through full ankle range of motion. The EMG (RMS of evertors and invertors was measured immediately after the three taping ways (no tape, Kinesio tape, and athletic tape with a one-week interval between each taping. Results: Spa-care Kinesiotape significantly reduced evertors and invertors EMG (RMS compared with no tape or athletic tape in patients with chronic ankle sprain. Mean± SD of the evertors was 0.7 (±0.1 for no tape and 0.58 (±0.2 for Kinesio tape. The P value was 0.000 for kinesio tape in evertors compared with no tape. Also, mean± SD of the invertors was 0.87 (±0.23 for no tape, and 0.54 (±0.1 for Kinesio tape and the P value was 0.001 for Kinesio tape in invertors compared with no tape. Conclusion: Spa-care Kinesio tape may be useful for reducing EMG activity of ankle muscles in a chronic ankle sprain.

  7. The influence of extracurricular activities on middle school students' science learning in China

    Science.gov (United States)

    Zhang, Danhui; Tang, Xing

    2017-07-01

    Informal science learning has been found to have effects on students' science learning. Through the use of secondary data from a national assessment of 7410 middle school students in China, this study explores the relationship among five types of extracurricular science activities, learning interests, academic self-concept, and science achievement. Structural equation modelling was used to investigate the influence of students' self-chosen and school-organised extracurricular activities on science achievement through mediating interests and the academic self-concept. Chi-square tests were used to determine whether there was an opportunity gap in the student's engagement in extracurricular activities. The students' volunteer and school-organised participation in extracurricular science activities had a positive and indirect influence on their science achievement through the mediating variables of their learning interests and academic self-concept. However, there were opportunity gaps between different groups of students in terms of school location, family background, and especially the mother's education level. Students from urban areas with better-educated mothers or higher socioeconomic status are more likely to access diverse science-related extracurricular activities.

  8. Analysing the influence of human activity on runoff in the Weihe River basin

    Directory of Open Access Journals (Sweden)

    C. Shen

    2015-05-01

    Full Text Available Changing runoff patterns can have profound effects on the economic development of river basins. To assess the impact of human activity on runoff in the Weihe River basin, principal component analysis (PCA was applied to a set of 17 widely used indicators of economic development to construct general combined indicators reflecting different types of human activity. Grey relational analysis suggested that the combined indicator associated with agricultural activity was most likely to have influenced the changes in runoff observed within the river basin during 1994–2011. Curve fitting was then performed to characterize the relationship between the general agricultural indicator and the measured runoff, revealing a reasonably high correlation (R2 = 0.393 and an exponential relationship. Finally, a sensitivity analysis was performed to assess the influence of the 17 individual indicators on the measured runoff, confirming that indicators associated with agricultural activity had profound effects whereas those associated with urbanization had relatively little impact.

  9. Development of scales to assess children's perceptions of friend and parental influences on physical activity

    Directory of Open Access Journals (Sweden)

    Brockman Rowan

    2009-10-01

    Full Text Available Abstract Background Many children do not meet physical activity guidelines. Parents and friends are likely to influence children's physical activity but there is a shortage of measures that are able to capture these influences. Methods A new questionnaire with the following three scales was developed: 1 Parental influence on physical activity; 2 Motives for activity with friends scale; and 3 Physical activity and sedentary group normative values. Content for each scale was informed by qualitative work. One hundred and seventy three, 10-11 year old children completed the new questionnaire twice, one week apart. Participants also wore an accelerometer for 5 days and mean minutes of moderate to vigorous physical activity, light physical activity and sedentary time per day were obtained. Test-retest reliability of the items was calculated and Principal Component analysis of the scales performed and sub-scales produced. Alphas were calculated for main scales and sub-scales. Correlations were calculated among sub-scales. Correlations between each sub-scale and accelerometer physical activity variables were calculated for all participants and stratified by sex. Results The Parental influence scale yielded four factors which accounted for 67.5% of the variance in the items and had good (α > 0.7 internal consistency. The Motives for physical activity scale yielded four factors that accounted for 66.1% and had good internal consistency. The Physical activity norms scale yielded 4 factors that accounted for 67.4% of the variance, with good internal consistency for the sub-scales and alpha of .642 for the overall scale. Associations between the sub-scales and physical activity differed by sex. Although only 6 of the 11 sub-scales were significantly correlated with physical activity there were a number of associations that were positively correlated >0.15 indicating that these factors may contribute to the explanation of children's physical activity

  10. Study on the Influence of Refreshment/Activation Cycles and Irrigants on Mechanical Cleaning Efficiency During Ultrasonic Activation of the Irrigant

    NARCIS (Netherlands)

    van der Sluis, Lucas W. M.; Vogels, Maikel P. J. M.; Verhaagen, Bram; Macedo, Ricardo; Wesselink, Paul R.

    Introduction: The aims of this study were to evaluate dentin debris removal from the root canal during ultrasonic activation of sodium hypochlorite (2% and 10%), carbonated water, and distilled water and to determine the influence of 3 ultrasonic refreshment/activation cycles of the irrigant by

  11. Study on the influence of refreshment/activation cycles and irrigants on mechanical cleaning efficiency during ultrasonic activation of the irrigant

    NARCIS (Netherlands)

    van der Sluis, L.W.M.; Vogels, M.P.J.M.; Verhaagen, B.; Macedo, R.; Wesselink, P.R.

    2010-01-01

    Introduction: The aims of this study were to evaluate dentin debris removal from the root canal during ultrasonic activation of sodium hypochlorite (2% and 10%), carbonated water, and distilled water and to determine the influence of 3 ultrasonic refreshment/activation cycles of the irrigant by

  12. Influence of grain activation conditions on functional characteristics of brown rice flour.

    Science.gov (United States)

    Singh, Arashdeep; Sharma, Savita; Singh, Baljit

    2017-09-01

    Grain activation is a natural processing technique that can be used to produce modified flours without chemical modification. Functional characteristics of brown rice flour as influenced by grain activation time and temperatures were investigated. Germination temperatures at 25 ℃, 30 ℃ and 35 ℃ and time for 12, 24, 36 and 48 h significantly influenced the functional properties of flour with modification of starch, protein and high enzymatic activity. Significant decrease in the bulk density, water absorption and swelling power of brown rice flour was observed in comparison to non-germinated flour. Gel consistency and oil absorption capacity of brown rice flour increased as the grain activation time and temperature were increased. Native flour had lowest emulsion and foaming properties, while increase in grain activation time and temperature enhanced the emulsifying and foaming properties of flour. Paste clarity of native flour was 54% which was reduced to 25.17%; however, increase in germination time and temperature increased the % synersis values of germinated flour. Native flour had least gelation concentration of 12% which increased to 25% after 48 h of germination at 35 ℃. Overall, germination can be used as a natural way to modify the functional properties of brown rice flours for their utilization in variety food products.

  13. The influence of alcohol consumption on sickness presenteeism and impaired daily activities. The WIRUS screening study.

    Science.gov (United States)

    Aas, Randi Wågø; Haveraaen, Lise; Sagvaag, Hildegunn; Thørrisen, Mikkel Magnus

    2017-01-01

    Alcohol use is a global health issue and may influence activity performance in a variety of domains, including the occupational and domestic spheres. The aim of the study was to examine the influence of annual drinking frequency and binge drinking (≥6 units at one occasion) on activity impairments both at work (sickness presenteeism) and outside the workplace. Employees (n = 3278), recruited from 14 Norwegian private and public companies, responded to a questionnaire containing questions from the Alcohol Use Disorders Identification Test (AUDIT) and the Workplace Productivity and Activity Impairment questionnaire (WPAI). Multiple hierarchical regression analyses revealed that binge drinking was associated with both sickness presenteeism and impaired daily activities, even after controlling for gender, age, educational level, living status and employment sector. Annual drinking frequency was associated with impaired daily activities, but not sickness presenteeism. Binge drinking seems to have a stronger influence on activity performance both at work and outside the workplace than drinking frequency. Interventions targeting alcohol consumption should benefit from focusing on binge drinking behavior.

  14. The influence of alcohol consumption on sickness presenteeism and impaired daily activities. The WIRUS screening study.

    Directory of Open Access Journals (Sweden)

    Randi Wågø Aas

    Full Text Available Alcohol use is a global health issue and may influence activity performance in a variety of domains, including the occupational and domestic spheres. The aim of the study was to examine the influence of annual drinking frequency and binge drinking (≥6 units at one occasion on activity impairments both at work (sickness presenteeism and outside the workplace.Employees (n = 3278, recruited from 14 Norwegian private and public companies, responded to a questionnaire containing questions from the Alcohol Use Disorders Identification Test (AUDIT and the Workplace Productivity and Activity Impairment questionnaire (WPAI.Multiple hierarchical regression analyses revealed that binge drinking was associated with both sickness presenteeism and impaired daily activities, even after controlling for gender, age, educational level, living status and employment sector. Annual drinking frequency was associated with impaired daily activities, but not sickness presenteeism.Binge drinking seems to have a stronger influence on activity performance both at work and outside the workplace than drinking frequency. Interventions targeting alcohol consumption should benefit from focusing on binge drinking behavior.

  15. Dual-Task Performance: Influence of Frailty, Level of Physical Activity, and Cognition.

    Science.gov (United States)

    Giusti Rossi, Paulo; Pires de Andrade, Larissa; Hotta Ansai, Juliana; Silva Farche, Ana Claudia; Carnaz, Leticia; Dalpubel, Daniela; Ferriolli, Eduardo; Assis Carvalho Vale, Francisco; de Medeiros Takahashi, Anielle Cristhine

    2018-03-08

    Cognition and level of physical activity have been associated with frailty syndrome. The development of tools that assess deficits related to physical and cognitive frailties simultaneously are of common interest. However, little is known about how much these aspects influence the performance of dual-task tests. Our aims were (a) to verify the influence of frailty syndrome and objectively measured physical activity and cognition on the Timed Up and Go (TUG) test and Timed Up and Go associated with dual-task (TUG-DT) performances; and (b) to compare TUG and TUG-DT performances between older adults who develop frailty syndrome. Sixty-four community-dwelling older adults were divided into frail, prefrail, and nonfrail groups, according to frailty phenotype. Assessments included anamnesis, screening of frailty syndrome, cognitive assessment (Addenbrooke's cognitive examination), placement of a triaxial accelerometer to assess level of physical activity, and TUG and TUG-DT (TUG associated with a motor-cognitive task of calling a phone number) performances. After 7 days, the accelerometer was removed. A multiple linear regression was applied to identify which independent variables could explain performances in the TUG and TUG-DT. Subsequently, the analysis of covariance test, adjusted for age, cognition, and level of physical activity covariates, was used to compare test performances. There were no differences in cognition between groups. Significant differences in the level of physical activity were found in the frail group. Compared with the frail group, the nonfrail group required less time and fewer steps to complete the TUG. Regarding the TUG-DT, cognition and age influenced the time spent and number of steps, respectively; however, no differences were found between groups. Frail older adults presented worse performance in the TUG when compared with nonfrail older adults. The dual-task test does not differentiate older adults with frailty syndrome, regardless of

  16. The Interplay of Networking Activities and Internal Knowledge Actions for Subsidiary Influence within MNCs

    DEFF Research Database (Denmark)

    Najafi-Tavani, Zhaleh; Giroud, Axèle; Andersson, Ulf

    2014-01-01

    in the UK. The results indicate that the possession of strategic resources (knowledge or embedded relations) increases subsidiary influence only when the knowledge is transferred back to headquarters. Importantly, the impact of subsidiary-headquarters embeddedness, external embeddedness and knowledge......Knowledge-based and network-based activities are known determinants of foreign subsidiary influence. We demonstrate that the interaction between these factors is essential in understanding how subsidiaries gain influence within an MNC. We test this using data on 184 foreign-owned subsidiaries...... development on influence is mediated by the extent of reverse knowledge transfer. This mediating role sheds new light on the antecedents to subsidiary influence....

  17. Spent fuel performance assessment (SPA) for a hypothetical repository in crystalline formations in Germany

    International Nuclear Information System (INIS)

    Luehrmann, L.; Noseck, U.; Storck, R.

    2000-07-01

    Within the framework of this project a first long-term safety assessment study for a generic German repository with spent nuclear fuel in granite host formations has been performed. Conceptual models have been developed and implemented into the numerical codes. These models describe the relevant processes in the near and far field of the repository. For the nuclide mobilisation and the diffusion-controlled transport through the bentonite barrier the computer code GRAPOS for far-field transport the code CHETMAD has been developed. Transport in the far field has been assumed to take place in a fracture network. As retardation mechanism matrix diffusion accompanied by linear equilibrium sorption on the rock matrix is considered. Both codes have been tested by intercomparison with codes of other countries. The dose rates have been calculated by the code EXCON considering the transport pathways into the biosphere. A reference scenario has been defined. It considers instantaneous saturation of the bentonite immediately after the operational phase of the repository, failure of all containers after 1000 years, diffusion through the bentonite, transport through fractured dykes, which represent a fast transport pathway in the low permeability region of the granite. The nuclide mobilization has been calculated according to a common source term which has been developed by all participants of the SPA project. It is assumed that 25% of the containers are connected to the considered transport pathway in the far field. The nuclides are transported to layers close to the surface. The contaminated water is pumped from a surface well and used for drinking, irrigation, cattle feed and fish ponds. (orig.) [de

  18. Physical activity influences the immune system of breast cancer patients

    Directory of Open Access Journals (Sweden)

    Thorsten Schmidt

    2017-01-01

    Full Text Available It has been suggested that physical activity in breast cancer patients can not only improve quality of life. Influences on physical and psychological levels have been evaluated, but effects on the immune system of breast cancer patients are hardly known. A PubMed search identified relevant trials and meta-analyses from 1970 to 2013. This review summarizes the results of international studies and the current discussion of effects of physical activity on the immune system of breast cancer patients. Highlighted are effects of physical activity on the immune system. Seven original articles and 14 reviews included in this review. Two original and the review articles includes other tumor entities besides breast cancer.Evaluated methods such as dose-response relationships for exercise in oncology, hardly exist. Increased immunological anti-cancer activity due to physical activity is probably mediated via an increase in number and cytotoxicity of monocytes and natural killer cells and cytokines.

  19. Study on the Influence of Refreshment/Activation Cycles and Irrigants on Mechanical Cleaning Efficiency During Ultrasonic Activation of the Irrigant

    NARCIS (Netherlands)

    van der Sluis, Lucas W.M.; Vogels, Maikel P.J.M.; Verhaagen, B.; Macedo, Ricardo; Wesselink, Paul R.

    2010-01-01

    Introduction The aims of this study were to evaluate dentin debris removal from the root canal during ultrasonic activation of sodium hypochlorite (2% and 10%), carbonated water, and distilled water and to determine the influence of 3 ultrasonic refreshment/activation cycles of the irrigant by using

  20. Separating Active and Passive Influences on Stomatal Control of Transpiration[OPEN

    Science.gov (United States)

    McAdam, Scott A.M.; Brodribb, Timothy J.

    2014-01-01

    Motivated by studies suggesting that the stomata of ferns and lycophytes do not conform to the standard active abscisic acid (ABA) -mediated stomatal control model, we examined stomatal behavior in a conifer species (Metasequoia glyptostroboides) that is phylogenetically midway between the fern and angiosperm clades. Similar to ferns, daytime stomatal closure in response to moderate water stress seemed to be a passive hydraulic process in M. glyptostroboides immediately alleviated by rehydrating excised shoots. Only after prolonged exposure to more extreme water stress did active ABA-mediated stomatal closure become important, because foliar ABA production was triggered after leaf turgor loss. The influence of foliar ABA on stomatal conductance and stomatal aperture was highly predictable and additive with the passive hydraulic influence. M. glyptostroboides thus occupies a stomatal behavior type intermediate between the passively controlled ferns and the characteristic ABA-dependent stomatal closure described in angiosperm herbs. These results highlight the importance of considering phylogeny as a major determinant of stomatal behavior. PMID:24488969

  1. The Influence of the Characteristics of Mathematical Outdoor Activities in Mobile Environments on Students' Emotions

    Directory of Open Access Journals (Sweden)

    Wajeeh M. Daher

    2012-04-01

    Full Text Available This research attempted to find out how the characteristics of outdoor activities carried out with the mobile phone influence students' emotions. The research findings point at the following components related to the activity as influencing students' emotions: The activity novelty, the activity theme (related to everyday life, related to a new subject related to the students themselves or to an issue or a subject that the students like to do, etc., the activity conditions (its physical part is easy/uneasy to perform, resources are available, etc., the outer environment conditions (hot, warm, cold, etc., the roles which the activity enables (these roles may or may not satisfy a student, the learning method enabled in the activity (exploring mathematical ideas independently, exploring mathematics collaboratively, etc., the challenge or competition associated with the activity (it needs persistence, attention, etc.. These components show that taking care of students' leaning emotions in outdoor mathematical activities can be achieved through paying attention to different aspects of the activity which are outlined above.

  2. Perceived influence and college students' diet and physical activity behaviors: an examination of ego-centric social networks.

    Science.gov (United States)

    Harmon, Brook E; Forthofer, Melinda; Bantum, Erin O; Nigg, Claudio R

    2016-06-06

    Obesity is partially a social phenomenon, with college students particularly vulnerable to changes in social networks and obesity-related behaviors. Currently, little is known about the structure of social networks among college students and their potential influence on diet and physical activity behaviors. The purpose of the study was to examine social influences impacting college students' diet and physical activity behaviors, including sources of influence, comparisons between sources' and students' behaviors, and associations with meeting diet and physical activity recommendations. Data was collected from 40 students attending college in Hawaii. Participants completed diet and physical activity questionnaires and a name generator. Participants rated nominees' influence on their diet and physical activity behaviors as well as compared nominees' behaviors to their own. Descriptive statistics were used to look at perceptions of influence across network groups. Logistic regression models were used to examine associations between network variables and odds of meeting recommendations. A total of 325 nominations were made and included: family (n = 116), college friends (n = 104), high school friends (n = 87), and significant others (n = 18). Nearly half of participants were not from Hawaii. Significant others of non-Hawaii students were perceived to be the most influential (M(SD) = 9(1.07)) and high school friends the least influential (M(SD) = 1.31(.42)) network. Overall, perceived influence was highest for diet compared to physical activity, but varied based on comparisons with nominees' behaviors. Significant others were most often perceived has having similar (44 %) or worse (39 %) eating behaviors than participants, and those with similar eating behaviors were perceived as most influential (M(SD) = 9.25(1.04)). Few associations were seen between network variables and odds of meeting recommendations. Among the groups nominated, high

  3. Perceived influence and college students’ diet and physical activity behaviors: an examination of ego-centric social networks

    Directory of Open Access Journals (Sweden)

    Brook E. Harmon

    2016-06-01

    Full Text Available Abstract Background Obesity is partially a social phenomenon, with college students particularly vulnerable to changes in social networks and obesity-related behaviors. Currently, little is known about the structure of social networks among college students and their potential influence on diet and physical activity behaviors. The purpose of the study was to examine social influences impacting college students’ diet and physical activity behaviors, including sources of influence, comparisons between sources’ and students’ behaviors, and associations with meeting diet and physical activity recommendations. Methods Data was collected from 40 students attending college in Hawaii. Participants completed diet and physical activity questionnaires and a name generator. Participants rated nominees’ influence on their diet and physical activity behaviors as well as compared nominees' behaviors to their own. Descriptive statistics were used to look at perceptions of influence across network groups. Logistic regression models were used to examine associations between network variables and odds of meeting recommendations. Results A total of 325 nominations were made and included: family (n = 116, college friends (n = 104, high school friends (n = 87, and significant others (n = 18. Nearly half of participants were not from Hawaii. Significant others of non-Hawaii students were perceived to be the most influential (M(SD = 9(1.07 and high school friends the least influential (M(SD = 1.31(.42 network. Overall, perceived influence was highest for diet compared to physical activity, but varied based on comparisons with nominees’ behaviors. Significant others were most often perceived has having similar (44 % or worse (39 % eating behaviors than participants, and those with similar eating behaviors were perceived as most influential (M(SD = 9.25(1.04. Few associations were seen between network variables and odds of meeting

  4. Microbial ecology, bacterial pathogens, and antibiotic resistant genes in swine manure wastewater as influenced by three swine management systems.

    Science.gov (United States)

    Brooks, John P; Adeli, Ardeshir; McLaughlin, Michael R

    2014-06-15

    The environmental influence of farm management in concentrated animal feeding operations (CAFO) can yield vast changes to the microbial biota and ecological structure of both the pig and waste manure lagoon wastewater. While some of these changes may not be negative, it is possible that CAFOs can enrich antibiotic resistant bacteria or pathogens based on farm type, thereby influencing the impact imparted by the land application of its respective wastewater. The purpose of this study was to measure the microbial constituents of swine-sow, -nursery, and -finisher farm manure lagoon wastewater and determine the changes induced by farm management. A total of 37 farms were visited in the Mid-South USA and analyzed for the genes 16S rRNA, spaQ (Salmonella spp.), Camp-16S (Campylobacter spp.), tetA, tetB, ermF, ermA, mecA, and intI using quantitative PCR. Additionally, 16S rRNA sequence libraries were created. Overall, it appeared that finisher farms were significantly different from nursery and sow farms in nearly all genes measured and in 16S rRNA clone libraries. Nearly all antibiotic resistance genes were detected in all farms. Interestingly, the mecA resistance gene (e.g. methicillin resistant Staphylococcus aureus) was below detection limits on most farms, and decreased as the pigs aged. Finisher farms generally had fewer antibiotic resistance genes, which corroborated previous phenotypic data; additionally, finisher farms produced a less diverse 16S rRNA sequence library. Comparisons of Camp-16S and spaQ GU (genomic unit) values to previous culture data demonstrated ratios from 10 to 10,000:1 depending on farm type, indicating viable but not cultivatable bacteria were dominant. The current study indicated that swine farm management schemes positively and negatively affect microbial and antibiotic resistant populations in CAFO wastewater which has future "downstream" implications from both an environmental and public health perspective. Published by Elsevier Ltd.

  5. Influences of climacteric in female sexual activity

    Directory of Open Access Journals (Sweden)

    Anthonio Alisancharles Batista de Almeida

    2016-01-01

    Full Text Available Objective: to identify complaints of sexual function related to climacteric symptoms among women in climacteric age. Methods: this is an descritive study. A sample of 330 women aged from 35 to 65 years old, with three previous Pap tests. We used a semi-structured questionnaire developed by the researchers. A descriptive statistical analysis was performed having the central tendency of proportion and measure the average as a parameter. Results: it was evidenced that 50.0% were between 35-45 years, 73.0% were sexually active, 59.4% had decreased libido, and 58.5% reported dyspareunia. Conclusion: it is necessary that the health services and professionals are aware of the influence of climacteric on women’s health to develop strategies aimed at quality of life.

  6. Physical activity levels of community-dwelling older adults are influenced by winter weather variables.

    Science.gov (United States)

    Jones, G R; Brandon, C; Gill, D P

    2017-07-01

    Winter weather conditions may negatively influence participation of older adults in daily physical activity (PA). Assess the influence of winter meteorological variables, day-time peak ambient temperature, windchill, humidity, and snow accumulation on the ground to accelerometer measured PA values in older adults. 50 community-dwelling older adults (77.4±4.7yrs; range 71-89; 12 females) living in Southwestern Ontario (Latitude 42.9°N Longitude 81.2° W) Canada, wore a waist-borne accelerometer during active waking hours (12h) for 7 consecutive days between February and April 2007. Hourly temperature, windchill, humidity, and snowfall accumulation were obtained from meteorological records and time locked to hourly accelerometer PA values. Regression analysis revealed significant relationships between time of day, ambient daytime high temperature and a humidity for participation in PA. Windchill temperature added no additional influence over PA acclamation already influenced by ambient day-time temperature and the observed variability in PA patterns relative to snow accumulation over the study period was too great to warrant its inclusion in the model. Most PA was completed in the morning hours and increased as the winter month's transitioned to spring (February through April). An equation was developed to adjust for winter weather conditions using temperature, humidity and time of day. Accurate PA assessment during the winter months must account for the ambient daytime high temperatures, humidity, and time of day. These older adults were more physically active during the morning hours and became more active as the winter season transitioned to spring. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Implementing an Active Learning Environment to Influence Students' Motivation in Biochemistry

    Science.gov (United States)

    Cicuto, Camila Aparecida Tolentino; Torres, Bayardo Baptista

    2016-01-01

    The Biochemistry: Biomolecules Structure and Metabolism course's goal is to promote meaningful learning through an active learning environment. Thus, study periods (SP) and discussion groups (DG) are used as a substitute for lecture classes. The goal of this study was to evaluate how this learning environment influences students' motivation (n =…

  8. The influence of neutron activated products in BIXS method for tungsten

    International Nuclear Information System (INIS)

    Yang, Yang; Peng, Taiping; Chen, Zhilin; Zhang, Zhe; Song, Honghu

    2016-01-01

    Highlights: • An approach is proposed to assess the influence of neutron activated products in BIXS method for tungsten based on Monte Carlo simulations. • Six principal radioactive neutron activated products (W-181, W-185, W-187, Ta-182, Re-186 and Re-188) with exhaustive decay data were included in the calculation to simulate the real condition. • W-187 strongly affects the tritium measurement shortly after DT experiments and about one month later W-181, W-185 and Ta-182 dominate the effects of neutron activated products. • The intensity of spectrum devoted by NAPs is as much as 10.6 times larger than by tritium in the same region of interest (ROI) directly after reactor shutdown, while it will reduce to 0.83% after 19 months. - Abstract: Tritium β-decay Induced X-ray Spectroscopy (BIXS) is a promising method to obtain tritium retention details both on surface and in bulk of plasma facing materials (PFMs) in magnetic fusion devices. Influence of neutron activated products (NAPs) is one of the primary problems in BIXS, since the energy of Compton scattering photons and characteristic X-rays is close to the range of tritium β-rays. In this paper, Monte Carlo simulation was introduced to evaluate effects of NAPs in BIXS measurements for tungsten. Three steps are included in simulation, neutron flux simulation to reckon the neutron flux in PFMs based on the simplified model of ITER, activated products calculation to compute the distribution of NAPs in PFMs and radiation spectra simulation to calculate the spectra of NAPs in PFMs sample. Six typical nuclides (including W-185, W-181 and Re-188, etc.) produced by neutron irradiation were considered in this study. Finally, influence of NAPs was estimated quantitatively with the assumption that 1% of DT fuel retained in PFMs uniformly. It is found that the intensity of spectrum devoted by NAPs is as much as 10.6 times larger than it by tritium in the same region of interest (ROI) directly after reactor shutdown

  9. The influence of neutron activated products in BIXS method for tungsten

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Yang; Peng, Taiping, E-mail: yangyanginpc@163.com; Chen, Zhilin; Zhang, Zhe; Song, Honghu

    2016-12-15

    Highlights: • An approach is proposed to assess the influence of neutron activated products in BIXS method for tungsten based on Monte Carlo simulations. • Six principal radioactive neutron activated products (W-181, W-185, W-187, Ta-182, Re-186 and Re-188) with exhaustive decay data were included in the calculation to simulate the real condition. • W-187 strongly affects the tritium measurement shortly after DT experiments and about one month later W-181, W-185 and Ta-182 dominate the effects of neutron activated products. • The intensity of spectrum devoted by NAPs is as much as 10.6 times larger than by tritium in the same region of interest (ROI) directly after reactor shutdown, while it will reduce to 0.83% after 19 months. - Abstract: Tritium β-decay Induced X-ray Spectroscopy (BIXS) is a promising method to obtain tritium retention details both on surface and in bulk of plasma facing materials (PFMs) in magnetic fusion devices. Influence of neutron activated products (NAPs) is one of the primary problems in BIXS, since the energy of Compton scattering photons and characteristic X-rays is close to the range of tritium β-rays. In this paper, Monte Carlo simulation was introduced to evaluate effects of NAPs in BIXS measurements for tungsten. Three steps are included in simulation, neutron flux simulation to reckon the neutron flux in PFMs based on the simplified model of ITER, activated products calculation to compute the distribution of NAPs in PFMs and radiation spectra simulation to calculate the spectra of NAPs in PFMs sample. Six typical nuclides (including W-185, W-181 and Re-188, etc.) produced by neutron irradiation were considered in this study. Finally, influence of NAPs was estimated quantitatively with the assumption that 1% of DT fuel retained in PFMs uniformly. It is found that the intensity of spectrum devoted by NAPs is as much as 10.6 times larger than it by tritium in the same region of interest (ROI) directly after reactor shutdown

  10. Design of a Linear Gaussian Control Law for an Adaptive Optics System

    Science.gov (United States)

    1990-12-01

    3-7 3.4. X-Axis Slice of Actuator :#49 Influence Function .. .. .... ...... ...... 3-9 3.5. Approximate Influence Function for Actuator #49... influence function is a mathematical representation of the effect of a single ac- tuator voltage on the local mirror shape. Usually, the influence ... function is nonzero only in the vicinity of the actuator: the influence function of an actualor has a limited spa- tial domain. Several factors affect the

  11. Erosion influences the seismicity of active thrust faults.

    Science.gov (United States)

    Steer, Philippe; Simoes, Martine; Cattin, Rodolphe; Shyu, J Bruce H

    2014-11-21

    Assessing seismic hazards remains one of the most challenging scientific issues in Earth sciences. Deep tectonic processes are classically considered as the only persistent mechanism driving the stress loading of active faults over a seismic cycle. Here we show via a mechanical model that erosion also significantly influences the stress loading of thrust faults at the timescale of a seismic cycle. Indeed, erosion rates of about ~0.1-20 mm yr(-1), as documented in Taiwan and in other active compressional orogens, can raise the Coulomb stress by ~0.1-10 bar on the nearby thrust faults over the inter-seismic phase. Mass transfers induced by surface processes in general, during continuous or short-lived and intense events, represent a prominent mechanism for inter-seismic stress loading of faults near the surface. Such stresses are probably sufficient to trigger shallow seismicity or promote the rupture of deep continental earthquakes up to the surface.

  12. July 1974 solar events: a possible lower limit for microwave activity

    Energy Technology Data Exchange (ETDEWEB)

    Kaufmann, P; Iacomo, P Jr; Koppe, E H; Marques dos Santos, P; Schaal, R E [Universidade Mackenzie, Sao Paulo (Brazil). Centro de Radio-Astronomia e Astrofisica; Blakey, J R [Surrey Univ., Guildford (UK). Dept. of Physics

    1975-11-01

    The active region McMath 10433 was the source of several flares and radio outbursts during the early part of July 1974. This region was tracked continuously, for several periods during the month at 22.2 GHz using a telescope with a 4 minutes of arc beam. Comparison with the results obtained simultaneously with a normal 7 GHz solar instrument indicate that there is important burst activity occurring at levels below the detection limit of normal solar patrol instruments. The time-development morphology of these bursts is similar to those normally observed and has enabled the simple events to be re-interpreted. A completely new type of event-the fast absorption-has also been recognized. The correlation of the microwave events with SPA events observed on VLF propagation is also discussed.

  13. A place for play? The influence of the home physical environment on children's physical activity and sedentary behaviour.

    Science.gov (United States)

    Maitland, Clover; Stratton, Gareth; Foster, Sarah; Braham, Rebecca; Rosenberg, Michael

    2013-08-17

    The home environment is an important influence on the sedentary behaviour and physical activity of children, who have limited independent mobility and spend much of their time at home. This article reviews the current evidence regarding the influence of the home physical environment on the sedentary behaviour and physical activity of children aged 8-14 years. A literature search of peer reviewed articles published between 2005 and 2011 resulted in 38 observational studies (21 with activity outcomes, 23 with sedentary outcomes) and 11 experimental studies included in the review. The most commonly investigated behavioural outcomes were television watching and moderate to vigorous physical activity. Media equipment in the home and to a lesser extent the bedroom were positively associated with children's sedentary behaviour. Physical activity equipment and the house and yard were not associated with physical activity, although environmental measures were exclusively self-reported. On the other hand, physical activity equipment was inversely associated with sedentary behaviours in half of studies. Observational studies that investigated the influence of the physical and social environment within the home space, found that the social environment, particularly the role of parents, was important. Experimental studies that changed the home physical environment by introducing a television limiting device successfully decreased television viewing, whereas the influence of introducing an active video game on activity outcomes was inconsistent. Results highlight that the home environment is an important influence on children's sedentary behaviour and physical activity, about which much is still unknown. While changing or controlling the home physical environment shows promise for reducing screen based sedentary behaviour, further interventions are needed to understand the broader impact of these changes. Future studies should prioritise investigating the influence of the home

  14. The decision to work after state pension age and how it affects quality of life: evidence from a 6-year English panel study.

    Science.gov (United States)

    Di Gessa, Giorgio; Corna, Laurie; Price, Debora; Glaser, Karen

    2018-01-10

    despite an increasing proportion of older people working beyond State Pension Age (SPA), little is known about neither the motivations for this decision nor whether, and to what extent, working beyond SPA affects quality of life (QoL). QoL was measured using the CASP-19 scale. Respondents in paid work beyond SPA were distinguished based on whether they reported financial constraints as the main reason for continuing in work. Linear regression models were used to assess the associations between paid work beyond SPA and CASP-19 scores among men aged 65-74 and women aged 60-69 (n = 2,502) cross-sectionally and over time using Wave 4 and Wave 7 of the English Longitudinal Study of Ageing. approximately, one in five respondents were in paid work beyond SPA, one-third of whom reported financial issues as the main reason. These individuals reported significantly lower CASP-19 scores (β = -1.21) compared with those who retired at the expected/usual age. Respondents who declared being in paid work beyond SPA because they enjoyed their work or wanted to remain active, reported significantly higher QoL (β = 1.62). Longitudinal analyses suggest that those who were working post-SPA by choice, but who had stopped working at follow-up, also reported marginally (P working beyond SPA need to be considered in light of individual motivations for extending working life. Given the trend towards working longer and the abolishment of mandatory retirement ages, it is important that older people maintain control over their decision to work in later life. © The Author(s) 2018 Published by Oxford University Press on behalf of the British Geriatrics Society.

  15. A systematic review - physical activity in dementia: The influence of the nursing home environment

    NARCIS (Netherlands)

    Anderiesen, H.; Scherder, E.J.A.; Goossens, R.H.; Sonneveld, M.

    2014-01-01

    Most older persons with dementia living in nursing homes spend their days without engaging in much physical activity. This study therefore looked at the influence that the environment has on their level of physical activity, by reviewing empirical studies that measured the effects of environmental

  16. Influences of Technology-Related Playful Activity and Thought on Moral Development

    Science.gov (United States)

    Bergen, Doris; Davis, Darrel

    2011-01-01

    Many early developmental theorists such as Freud, Erikson, Piaget, and Vygotsky suggested that play--which the authors of this article define as both playful activity and playful thought--had the power to influence the moral emotions, behaviors, and reasoning of children. More recent researchers have also found evidence of moral development in…

  17. Influence of Atmospheric Propagation on Performance of Laser Active Imaging System

    International Nuclear Information System (INIS)

    Li Yingchun; Sun Huayan; Guo Huichao; Zhao Yun

    2011-01-01

    Atmospheric propagation has serious influence on the performance of a good designed laser active imaging system. Atmospheric attenuation and turbulence are two main effects on laser atmospheric propagation. Imaging SNR (Signal-Noise-Ratio) and resolution are two key indexes to describe the performance of a laser active imaging system. Establishing the relation between system performance index and atmospheric propagation effect is significant. The paper analyzed the relation between imaging performance and atmospheric attenuation and turbulence through simulation. And also the experiments were done under different weather to validate the conclusion of simulation.

  18. Influencia genética de las proteínas surfactantes SP-A y SP-D en la neumonía, la gripe por A (H1N1) 2009 y el asma alérgico

    OpenAIRE

    Herrera Ramos, Estefanía

    2015-01-01

    Programa de doctorado: Salud pública: Epidemiología, nutrición y planificación [ES]La presente Tesis Doctoral plantea la hipótesis de que la variabilidad genética de las proteínas surfactantes A y D (SP-A y SP-D) pueden influir en la susceptibilidad y pronóstico de diversas enfermedades pulmonares. Esas variantes podrían utilizarse como marcadores para identificar a los subgrupos de individuos con mayor predisposición a desarrollar una de estas enf...

  19. Removal efficiency of methylene blue using activated carbon from waste banana stem: Study on pH influence

    Science.gov (United States)

    Misran, E.; Bani, O.; Situmeang, E. M.; Purba, A. S.

    2018-02-01

    The effort to remove methylene blue in artificial solution had been conducted using adsorption process. The abundant banana stem waste was utilized as activated carbon precursor. This study aimed to analyse the influence of solution pH to removal efficiency of methylene blue using activated carbon from banana stem as adsorbent. Activated carbon from banana stem was obtained by chemical activation using H3PO4 solution. Proximate analysis result showed that the activated carbon has 47.22% of fixed carbon. This value exhibited that banana stem was a potential adsorbent precursor. Methylene blue solutions were prepared at initial concentration of 50 ppm. The influence of solution pH was investigated with the use of 0.2 g adsorbent for 100 mL dye solution. The adsorption was conducted using shaker with at a constant rate of 100 rpm at room temperature for 90 minutes. The results showed that solution pH influenced the adsorption. The activated carbon from banana stem demonstrated satisfying performance since removal efficiencies of methylene blue were higher than 99%.

  20. Eventual physiological properties of radon dissolved in drinking water

    International Nuclear Information System (INIS)

    Garsou, J.; Lecomte, J.; Lagneaux, D.

    1978-01-01

    Natural radioactivity of spring waters in Spa basin is not correlated with some therapeutic or physiological activity. This statement is based on two arguments. The first one is of biological character, the second one is of epidemiological character. In fact the observations on an all aged human population accidentally submitted to a long ingestion of a radon-rich water at concentrations far higher than those of the spring waters in Spa basin, have been found not to show any physiological or pathological activity. (author)

  1. Lower limit of intensity for the solar activity in microwaves

    Energy Technology Data Exchange (ETDEWEB)

    Kaufmann, P; Iacomo, P Jr; Koppe, E H; dos Santos, P M; Schaal, R E [Universidade Mackenzie, Sao Paulo (Brazil). Centro de Radio-Astronomia e Astrofisica; Blakey, J R [Surrey Univ., Guildford (UK). Dept. of Physics

    1976-01-01

    The active region McMath 10433 has produced various flares and bursts in radio frequency in the beginning of july 1974. This region was scanned countinously in 22.2 GHz with a radio telescope showing a 4 min. arc beam, in various periods of the month. In comparison with the results simultaneously obtained with a normal solar radio telescope, in 7 GHz, it was verified that there is an important explosive activity in lower levels in the limit of detection of an usual patrolling instrument. The morphology of these events, in its progress in the time, is similar to that normaly known, and allowed, the re-interpretation of simple events. A completly new type of event was defined: the fast absorptions. The correlation of events in microwaves with 'SPA' recorded in 'VLF' propagation is also discussed.

  2. Parents' perception of their influence on their child's physical activity.

    Science.gov (United States)

    VanDerworp, Gwendolyn Kay; Ryan, Sarah-Jane

    2016-03-01

    Childhood physical activity (PA) has declined in the western world recently. To combat child inactivity, government programs have been organized to promote PA within families. It is important for physiotherapists to understand the influence parents perceive to have on their child's PA habits in order to better encourage a positive parental influence. The purpose of this study is to explore how parents perceive their influence on their child/children's PA through an interpretative phenomenological analysis (IPA) approach. This qualitative study used a phenomenological approach with semi-structured interviews conducted with five participants. The interviews were analyzed using elements of IPA. Master themes developed with their corresponding subthemes: creating an environment of opportunity--logistics, opportunities through encouragement and PA within the family, barriers to PA--barriers created by parents and barriers created by external factors, and parent and child interactions--children communicating interest and disinterest in PA and parent's attitudes toward children's disinterest. The findings suggest that parents perceive themselves to have a greater positive influence on their children rather than negative. The barriers that parents create are not perceived to prevent their child's PA but rather restrict it. Many participants reported enjoying doing PA with their children and used PA as an opportunity for family time, indicating a dual purpose for PA. © The Author(s) 2014.

  3. Growth and extracellular phosphatase activity of arbuscular mycorrhizal hyphae as influenced by soil organic matter

    DEFF Research Database (Denmark)

    Joner, E.J.; Jakobsen, I.

    1995-01-01

    Two experiments were set up to investigate the influence of soil organic matter on growth of arbuscular mycorrhizal (AM) hyphae and concurrent changes in soil inorganic P, organic P and phosphatase activity. A sandy loam soil was kept for 14 months under two regimes (outdoor where surplus...... additions. In soil with added clover alkaline phosphatase activity increased due to the presence of mycorrhizal hyphae. We suggest that mycorrhizas may influence the exudation of acid phosphatase by roots. Hyphae of G. invermaium did apparently not excrete extracellular phosphatases, but their presence may...

  4. In the company we keep: social physique anxiety levels differ around parents and peers.

    Science.gov (United States)

    Brunet, Jennifer; Sabiston, Catherine M

    2011-01-01

    This study examined the psychometric properties of two scales which assessed social physique anxiety (SPA) in the context of peers (peer SPA) and parents (parent SPA), and differences in reported levels of peer SPA and parent SPA. Young adults (N = 381, 161 males, M(age) = 18.69 years) completed self-report measures. Results supported the internal consistency, convergent validity and factor structure of the peer SPA and parent SPA scales. Also, participants reported significantly higher levels of peer SPA compared to parent SPA. Findings offer preliminary support for the investigation of contextualized SPA using the scales tested in this study, and suggest more research is needed to better understand the processes that may increase or decrease SPA when surrounded by peers and parents.

  5. On the influence of the alternation of two different cooling systems on dairy cow daily activities

    Directory of Open Access Journals (Sweden)

    Simona M.C. Porto

    2017-02-01

    Full Text Available Among the causes that influence cow welfare, heat stress induced by microclimatic conditions is one of the most relevant and many studies have investigated the efficacy of different cooling systems on animal health status. Nevertheless, the direct influence of the cooling systems on possible modifications of dairy cow behaviour has been addressed in a few studies and the related results were affected by the presence of a paddock, which gave a refuge from hot temperature. Since an alteration of the daily time budget spent by dairy cows in their usual activities can be associated with changes in their health status, this study investigated the effects of the alternation of two different cooling systems on lying, standing, and feeding behaviour of a group of dairy cows bred in a free-stall dairy house where animals had no access to a paddock. The barn was equipped with a fogging system associated with forced ventilation installed in the resting area and a sprinkler system associated with forced ventilation installed in the feeding area. The two systems were activated alternately. The results demonstrated that the management of the two cooling systems affected the analysed behaviours. Though the activation of the cooling system installed in the resting area encouraged the decubitus of animals in the stalls, the activation of that one of the feeding alley could not be able to influence the standing behaviour and had only a moderate positive influence on the feeding activity.

  6. Impedance Immunsensor Based on Interdigitated Array Microelectrode and its Experiment Parameter Optimization

    Directory of Open Access Journals (Sweden)

    Wen Ping Zhao

    2014-05-01

    Full Text Available This article accounts for a novel impedance immunosensor based on the specificity reaction of the antigen-antibody and the sensitivity of the interdigitated array microelectrode (IDAM for the determination of chlorpyrifos residues. The basic knowledge of immunoassay was in relation to its IDAM electrode surface modification, antibody immobilization, bovine serum albumin (BSA blocking and sample detection. The SPA was dropped onto the surface of IDAM electrode, used for binding antibody Fc fragments. Next, antibody was immobilized on the SPA modified electrode. Finally, BSA was employed to block the possible remaining active sites avoiding any nonspecific adsorption. Target chlorpyrifos was then captured by the immobilized antibody, resulting in a change in the impedance of the IDAM microelectrode surface. The fabrication procedure of the immunosensor and the sample detection were characterized by electrochemical impedance spectroscopy (EIS. The influences of the experiment parameters were investigated. Under optimized conditions, an excellent biosensor was fabricated. Many of the antibodies, enzymes and other reagents integral to immunoassays were very expensive, often hundreds of dollars per milligram, therefore miniaturization reduces reagent costs drastically. In this article the volume of the reagents was micro upgrade, the antibodies, SPA and BSA were 30 mL, the chlorpyrifos sample and detection solution were 50mL. The advantages of the immunosensor were exhibited in its better specificity, stability, selectivity and regeneration. The proposed method was proven to be a feasible quantitative method for chlorpyrifos analysis in vegetables and fruits.

  7. Factors influencing the determination of fluorite by means of neutron activation analysis

    International Nuclear Information System (INIS)

    Lutze, H.

    1975-01-01

    Proceeding from the necessity of a rapid analysis of fluorite by neutron activation of an unprepared drill core the influence of interfering elements, of inhomogeneous fluorite distribution, of the sample volume and of moisture are examined. Recommendations are given to overcome these interferences. (author)

  8. Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition.

    Science.gov (United States)

    Gao, Lu; Rabbitt, Elizabeth H; Condon, Jennifer C; Renthal, Nora E; Johnston, John M; Mitsche, Matthew A; Chambon, Pierre; Xu, Jianming; O'Malley, Bert W; Mendelson, Carole R

    2015-07-01

    The precise mechanisms that lead to parturition are incompletely defined. Surfactant protein-A (SP-A), which is secreted by fetal lungs into amniotic fluid (AF) near term, likely provides a signal for parturition; however, SP-A-deficient mice have only a relatively modest delay (~12 hours) in parturition, suggesting additional factors. Here, we evaluated the contribution of steroid receptor coactivators 1 and 2 (SRC-1 and SRC-2), which upregulate SP-A transcription, to the parturition process. As mice lacking both SRC-1 and SRC-2 die at birth due to respiratory distress, we crossed double-heterozygous males and females. Parturition was severely delayed (~38 hours) in heterozygous dams harboring SRC-1/-2-deficient embryos. These mothers exhibited decreased myometrial NF-κB activation, PGF2α, and expression of contraction-associated genes; impaired luteolysis; and elevated circulating progesterone. These manifestations also occurred in WT females bearing SRC-1/-2 double-deficient embryos, indicating that a fetal-specific defect delayed labor. SP-A, as well as the enzyme lysophosphatidylcholine acyltransferase-1 (LPCAT1), required for synthesis of surfactant dipalmitoylphosphatidylcholine, and the proinflammatory glycerophospholipid platelet-activating factor (PAF) were markedly reduced in SRC-1/-2-deficient fetal lungs near term. Injection of PAF or SP-A into AF at 17.5 days post coitum enhanced uterine NF-κB activation and contractile gene expression, promoted luteolysis, and rescued delayed parturition in SRC-1/-2-deficient embryo-bearing dams. These findings reveal that fetal lungs produce signals to initiate labor when mature and that SRC-1/-2-dependent production of SP-A and PAF is crucial for this process.

  9. Physical activity behaviors and influences among Chinese-American children aged 9-13 years: A qualitative study

    Science.gov (United States)

    Low physical activity is a major health issue among Chinese Americans. This study explored Chinese–American children's physical activity behaviors and influencing factors. Twenty-five children of Chinese or Taiwanese descent were interviewed to understand their favorite sports or physical activities...

  10. Modulation of brain activity during action observation: influence of perspective, transitivity and meaningfulness.

    Directory of Open Access Journals (Sweden)

    Sébastien Hétu

    Full Text Available The coupling process between observed and performed actions is thought to be performed by a fronto-parietal perception-action system including regions of the inferior frontal gyrus and the inferior parietal lobule. When investigating the influence of the movements' characteristics on this process, most research on action observation has focused on only one particular variable even though the type of movements we observe can vary on several levels. By manipulating the visual perspective, transitivity and meaningfulness of observed movements in a functional magnetic resonance imaging study we aimed at investigating how the type of movements and the visual perspective can modulate brain activity during action observation in healthy individuals. Importantly, we used an active observation task where participants had to subsequently execute or imagine the observed movements. Our results show that the fronto-parietal regions of the perception action system were mostly recruited during the observation of meaningless actions while visual perspective had little influence on the activity within the perception-action system. Simultaneous investigation of several sources of modulation during active action observation is probably an approach that could lead to a greater ecological comprehension of this important sensorimotor process.

  11. Advocates or cartographers? Scientific advisors and the narratives of German energy transition

    International Nuclear Information System (INIS)

    Leipprand, Anna; Flachsland, Christian; Pahle, Michael

    2017-01-01

    Political debate on energy in Germany has been shaped by two historically opposed discourses, one pushing for a transition to renewables, the other holding on to the status quo. Scientific policy advice (SPA) has been involved in their evolution from the beginning. This paper draws on the Advocacy Coalition Framework and on discourse and narrative theory to study the role of SPA in recent German energy policy. We explore 1) whether scientific advisors have been members of advocacy coalitions, and 2) how their contributions may have interacted with the evolution of the discourses and major narratives. We perform a qualitative text analysis of 50 SPA reports published between 2000 and 2015. We find that the majority of studies clearly take sides in the debate, and that in most cases the reports’ positions are fully transparent. Despite the polarization, SPA provides differentiated information on key aspects of the discourses, and alternative design options for policy instruments. We conclude that SPA contributions have improved the conditions for political consensus and compromise. Collectively, SPA studies provide a basis for mapping different policy pathways and their consequences. In the future, SPA should address additional critical issues such as coal phase-out and international leadership. - Highlights: • We explore the role of scientific policy advice in Germany's energy transition. • There is widespread, mostly transparent advocacy in scientific advisory reports. • We conclude that scientific policy advice has facilitated dialogue and compromise. • We discuss implications for future advisory activity and further improvements.

  12. Fibromyalgia, a missed comorbidity in spondyloarthritis: prevalence and impact on assessment and treatment.

    Science.gov (United States)

    Mease, Philip J

    2017-07-01

    Fibromyalgia is a clinical representation of the neurobiological phenomenon of central sensitization, characterized by chronic widespread pain, fatigue, sleep disturbance, and other symptoms. Fibromyalgia may occur in conjunction with chronic rheumatic diseases, driven by the effects of chronic pain and inflammation and likely influenced by the patient's genetic and psychoemotional background. This article reviews the data on prevalence of concomitant fibromyalgia and its impact on disease assessment in patients with spondyloarthritis (SpA) and psoriatic arthritis (PsA). Fibromyalgia occurs in 2-8% of the general population. In AxSpA cohorts the prevalence has been reported in 4-25%, and in PsA, 16-22%, the majority being female. Measures of disease activity which are comprised partly or wholly of patient-reported outcomes such as pain and patient global are significantly higher in patients with concomitant fibromyalgia and do not improve as much with treatment as more objective measures, a finding which has been observed in other diseases such as rheumatoid arthritis and lupus. Fibromyalgia occurs in a significant proportion of patients with SpA and PsA. Disease activity measures with subjective elements are conflated in patients with fibromyalgia and do not reliably assess true inflammatory disease. This needs to be taken into account when evaluating the impact of immunomodulatory therapy.

  13. A place for play? The influence of the home physical environment on children’s physical activity and sedentary behaviour

    Science.gov (United States)

    2013-01-01

    The home environment is an important influence on the sedentary behaviour and physical activity of children, who have limited independent mobility and spend much of their time at home. This article reviews the current evidence regarding the influence of the home physical environment on the sedentary behaviour and physical activity of children aged 8–14 years. A literature search of peer reviewed articles published between 2005 and 2011 resulted in 38 observational studies (21 with activity outcomes, 23 with sedentary outcomes) and 11 experimental studies included in the review. The most commonly investigated behavioural outcomes were television watching and moderate to vigorous physical activity. Media equipment in the home and to a lesser extent the bedroom were positively associated with children’s sedentary behaviour. Physical activity equipment and the house and yard were not associated with physical activity, although environmental measures were exclusively self-reported. On the other hand, physical activity equipment was inversely associated with sedentary behaviours in half of studies. Observational studies that investigated the influence of the physical and social environment within the home space, found that the social environment, particularly the role of parents, was important. Experimental studies that changed the home physical environment by introducing a television limiting device successfully decreased television viewing, whereas the influence of introducing an active video game on activity outcomes was inconsistent. Results highlight that the home environment is an important influence on children’s sedentary behaviour and physical activity, about which much is still unknown. While changing or controlling the home physical environment shows promise for reducing screen based sedentary behaviour, further interventions are needed to understand the broader impact of these changes. Future studies should prioritise investigating the influence of the

  14. Longitudinal examination of social and environmental influences on motivation for physical activity.

    Science.gov (United States)

    Richards, Elizabeth A; McDonough, Meghan; Fu, Rong

    2017-10-01

    Physical activity behavior is influenced by numerous factors including motivation, social interactions, and the walkability of the environment. To examine how social contexts and environmental features affect physical activity motivational processes across time. Participants (N=104) completed 3 monthly online surveys assessing self-determination theory constructs, social partners in physical activity, neighborhood walkability, and weekly physical activity. Longitudinal path analysis examined the degree to which physical activity was predicted by individual goals, orientation, and autonomy support and whether these associations were meditated by motivation and moderated by the social and environmental contexts of physical activity. The effect of controlled exercise orientations on physical activity was mediated by autonomous motivation. This association was stronger among those who perceived less crime in their neighborhoods. To improve the ability to tailor physical activity counseling it is important to understand how each person views exercise situations and to understand his/her social and neighborhood environments. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Study on the environmental movements and distributions of natural radioactive nuclides on the granite area (III)

    International Nuclear Information System (INIS)

    Morishima, Hiroshige; Koga, Taeko

    2000-03-01

    The natural radionuclides as K-40, uranium decay series and thorium decay series etc. are widely distributed on environment, but are not uniformly. These have influences various forms as the sources of terrecial environmental γ radiation and of radon in to the human life environment and make wide fluctuation seasonal and spatially on the environment. The environmental radiation is higher than that of the other on the west Japan where generally consist rich of granite strata. We deeply appreciate in regard to natural radiation and would carry the studies on the movement and distribution of natural radioactive nuclides on high background radiation area consisted rich granite strata. We have selected and observed on Ikeda mineral spring district Ota-shi Shimane pref., Misasa spa district, Tohaku-gun, Tottori pref. on Chugoku area, Muro district Uda-gun, Hachibuse district, Nafa-shi Nara pref., and Arima spa district, Hyogo-pref., Kawanishi-shi, Hyogo pref. on Kinki area and Masutomi spa, Koma-gun, Yamanashi pref., for HBRA, and Higashi-osaka-shi, Osaka pref., for CA. We have carried out the study on the environmental movement and distribution of natural radioactive nuclides containing radon and decay nuclides, and reported these results on following; (1) Radon measurements have been carried using cup typed radon and thoron monitors which are easy handling in spite of need of long sampling period, pico-rad method by active charcoal sampling and Pilon scintillation-cell with 300 ml volume by grub sampling. Accumulated radon monitors have been used cellulose nitrate (LR-115 type II, Kodak Co.) as solid state track detector. Among these characteristics of radon monitors, though minimum detectable limit of cup method for 3 months sampling is higher than those by the other method, it is able to measure mean Rn-222 concentration for 3 months. Rn-222 concentration by pico-rad method is able to get briefly mean concentration for 24 hours, is small detector and many sample are

  16. The efficacy and safety of etanercept in patients with rheumatoid arthritis and spondyloarthropathy on hemodialysis.

    Science.gov (United States)

    Senel, Soner; Kisacik, Bunyamin; Ugan, Yunus; Kasifoglu, Timucin; Tunc, Ercan; Cobankara, Veli

    2011-10-01

    We aimed to evaluate the efficacy and safety of long-term use of etanercept therapy in patients with spondyloarthropathy (SpA) and rheumatoid arthritis (RA) on hemodialysis (HD). Selected RA or SpA patients treated with etanercept under HD were retrospectively evaluated. Etanercept-related adverse events were closely recorded for all patients. At the follow-up, erythrocyte sedimentation rate and C-reactive protein levels were monitored. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) for SpA patients and Disease Activity Score (DAS28) for RA patients were measured at every 3 or 6 months. In total five end-stage renal disease (ESRD) patients were enrolled to the study. The causes of ESRD in the study subjects were amyloidosis (n = 2), analgesic nephropathy (n = 2), and nephrolithiasis (n = 1). Three were diagnosed as SpA and two were RA. All patients used etanercept. The median age was 39 years (range 22-72 years). The median disease duration was 12 years (range 2-20 years). The median follow-up after etanercept therapy was 18 months (range 5-33 months). DAS28 score decreased after the treatment and did not increase during follow-up in RA patients. BASDAI score decreased after the treatment during follow-up in three patients with SpA. At the follow-up, only one patient was diagnosed with septic arthritis. As a result of our study, etanercept treatment in RA and SpA patients on HD seems to be safe, well tolerated, and effective in most of the patients. Above all, due to impaired host defense in patients with ESRD, enhanced risk of infections should be kept in mind during follow-up period and larger trials are needed to prove the safety of etanercept in HD patients.

  17. Mechanism by which BMI influences leisure-time physical activity behavior.

    Science.gov (United States)

    Godin, Gaston; Bélanger-Gravel, Ariane; Nolin, Bertrand

    2008-06-01

    The objective of this prospective study was to clarify the mechanism by which BMI influences leisure-time physical activity. This was achieved in accordance with the assumptions underlying the Theory of Planned Behavior (TPB), considered as one of the most useful theories to predict behavior adoption. At baseline, a sample of 1,530 respondents completed a short questionnaire to measure intention and perceived behavioral control (PBC), the two proximal determinants of behavior of TPB. Past behavior, sociodemographic variables, and weight and height were also assessed. The dependent variable, leisure-time physical activity was assessed 3 months later. Hierarchical multiple regression analyses revealed that BMI is a direct predictor of future leisure-time physical activity, not mediated by the variables of TPB. Additional hierarchical analyses indicated that BMI was not a moderator of the intention-behavior and PBC-behavior relationships. The results of this study suggest that high BMI is a significant negative determinant of leisure-time physical activity. This observation reinforces the importance of preventing weight gain as a health promotion strategy for avoiding a sedentary lifestyle.

  18. Physical activity, but not sedentary time, influences bone strength in late adolescence.

    Science.gov (United States)

    Tan, Vina Ps; Macdonald, Heather M; Gabel, Leigh; McKay, Heather A

    2018-03-20

    Physical activity is essential for optimal bone strength accrual, but we know little about interactions between physical activity, sedentary time, and bone outcomes in older adolescents. Physical activity (by accelerometer and self-report) positively predicted bone strength and the distal and midshaft tibia in 15-year-old boys and girls. Lean body mass mediated the relationship between physical activity and bone strength in adolescents. To examine the influence of physical activity (PA) and sedentary time on bone strength, structure, and density in older adolescents. We used peripheral quantitative computed tomography to estimate bone strength at the distal tibia (8% site; bone strength index, BSI) and tibial midshaft (50% site; polar strength strain index, SSI p ) in adolescent boys (n = 86; 15.3 ± 0.4 years) and girls (n = 106; 15.3 ± 0.4 years). Using accelerometers (GT1M, Actigraph), we measured moderate-to-vigorous PA (MVPA Accel ), vigorous PA (VPA Accel ), and sedentary time in addition to self-reported MVPA (MVPA PAQ-A ) and impact PA (ImpactPA PAQ-A ). We examined relations between PA and sedentary time and bone outcomes, adjusting for ethnicity, maturity, tibial length, and total body lean mass. At the distal tibia, MVPA Accel and VPA Accel positively predicted BSI (explained 6-7% of the variance, p accounting for lean mass. Sedentary time did not independently predict bone strength at either site. Greater tibial bone strength in active adolescents is mediated, in part, by lean mass. Despite spending most of their day in sedentary pursuits, adolescents' bone strength was not negatively influenced by sedentary time.

  19. Influence of tourism and traffic on the Eurasian lynx hunting activity and daily movements

    Directory of Open Access Journals (Sweden)

    Belotti, E.

    2012-01-01

    Full Text Available Human presence influences survival of large carnivores in several ways and even outdoor activities can be a source of disturbance. As ungulate prey provide the Eurasian lynx (Lynx lynx with food for several nights and the pattern of lynx activity is mainly shaped by searching for and consuming large prey, the need to move decreases strongly while the prey is eaten. However, during the day, human activity may drive lynx to move to safe shelters and habitat features such as dense vegetation may increase tolerance. In the Bohemian Forest (Czech Republic, we found 116 prey killed by five GPS–collared lynxes. We tested whether the kill sites were located farther from roads or tourist trails than a set of randomly generated locations and whether presence of roads or tourist trails and habitat structure influenced the distance ‘kill site to daytime resting sites’. At night, with low human activity, lynxes did not avoid roads and even selected the surroundings of tourist trails. The distance ‘kill site to daytime resting sites’ correlated negatively with presence of habitat concealment and distance to tourist trails, suggesting that outdoor activities may have to be considered in lynx management plans.

  20. Solicitant -exciting plain bioclimate / Amara Balneoclimateric Resort, 

    Directory of Open Access Journals (Sweden)

    Munteanu Constantin

    2011-05-01

    Full Text Available Spa and balneotherapy is one of studying medicine and therapy and apply natural factors intherapy: natural mineral water springs and lakes mineralized, therapeuticmineral mud and peat, gas emanations and climate zones,orlocalities developed intosources respective treatment , the spa resort climate.Resources are the mineral spa and climatic treatment ,whose physicochemical properties meet the needs of prevention and health maintenance, strengthening and restoration of health, work capacity and physical and mental comfort of the individual.Climatic is a form of treatment, well-run, have fewer side effects than chemo therapeutictreatment and prolonged effects, because the way treatment is as close to normal activity in a relaxing environment.Bioclimate turn-applicant is characterized by general biological effects resulting from theapplication marked the central nervous system and autonomic and endocrine activity. Bioclimatic conditions, demanding aplain exciting resorts are located in northeasternbalneoclimatice Baragan, on the shores of salt lakes: Amara, Lacul Sarat.

  1. School Administrators' Perceptions of Factors that Influence Children's Active Travel to School

    Science.gov (United States)

    Price, Anna E.; Pluto, Delores M.; Ogoussan, Olga; Banda, Jorge A.

    2011-01-01

    Background: Increasing children's active travel to school may be 1 strategy for addressing the growing prevalence of obesity among school age children. Using the School Travel Survey, we examined South Carolina school district leaders' perceptions of factors that influence elementary and middle school students walking to school. Methods: Frequency…

  2. Momentary assessment of contextual influences on affective response during physical activity.

    Science.gov (United States)

    Dunton, Genevieve Fridlund; Liao, Yue; Intille, Stephen; Huh, Jimi; Leventhal, Adam

    2015-12-01

    Higher positive and lower negative affective response during physical activity may reinforce motivation to engage in future activity. However, affective response during physical activity is typically examined under controlled laboratory conditions. This research used ecological momentary assessment (EMA) to examine social and physical contextual influences on momentary affective response during physical activity in naturalistic settings. Participants included 116 adults (mean age = 40.3 years, 73% female) who completed 8 randomly prompted EMA surveys per day for 4 days across 3 semiannual waves. EMA surveys measured current activity level, social context, and physical context. Participants also rated their current positive and negative affect. Multilevel models assessed whether momentary physical activity level moderated differences in affective response across contexts controlling for day of the week, time of day, and activity intensity (measured by accelerometer). The Activity Level × Alone interaction was significant for predicting positive affect (β = -0.302, SE = 0.133, p = .024). Greater positive affect during physical activity was reported when with other people (vs. alone). The Activity Level × Outdoors interaction was significant for predicting negative affect (β = -0.206, SE = 0.097, p = .034). Lower negative affect during physical activity was reported outdoors (vs. indoors). Being with other people may enhance positive affective response during physical activity, and being outdoors may dampen negative affective response during physical activity. (c) 2015 APA, all rights reserved).

  3. Intrinsically disordered proteins aggregate at fungal cell-to-cell channels and regulate intercellular connectivity.

    Science.gov (United States)

    Lai, Julian; Koh, Chuan Hock; Tjota, Monika; Pieuchot, Laurent; Raman, Vignesh; Chandrababu, Karthik Balakrishna; Yang, Daiwen; Wong, Limsoon; Jedd, Gregory

    2012-09-25

    Like animals and plants, multicellular fungi possess cell-to-cell channels (septal pores) that allow intercellular communication and transport. Here, using a combination of MS of Woronin body-associated proteins and a bioinformatics approach that identifies related proteins based on composition and character, we identify 17 septal pore-associated (SPA) proteins that localize to the septal pore in rings and pore-centered foci. SPA proteins are not homologous at the primary sequence level but share overall physical properties with intrinsically disordered proteins. Some SPA proteins form aggregates at the septal pore, and in vitro assembly assays suggest aggregation through a nonamyloidal mechanism involving mainly α-helical and disordered structures. SPA loss-of-function phenotypes include excessive septation, septal pore degeneration, and uncontrolled Woronin body activation. Together, our data identify the septal pore as a complex subcellular compartment and focal point for the assembly of unstructured proteins controlling diverse aspects of intercellular connectivity.

  4. Transition metal ions mediated tyrosine based short peptide amphiphile nanostructures inhibit bacterial growth.

    Science.gov (United States)

    Joshi, Khashti Ballabh; Singh, Ramesh; Mishra, Narendra Kumar; Kumar, Vikas; Vinayak, Vandana

    2018-05-17

    We report the design and synthesis of biocompatible small peptide based molecule for the controlled and targeted delivery of the encapsulated bioactive metal ions via transforming their internal nanostructures. Tyrosine based short peptide amphiphile (sPA) was synthesized which self-assembled into β-sheet like secondary structures. The self assembly of the designed sPA was modulated by using different bioactive transition metal ions which is confirmed by spectroscopic and microscopic techniques. These bioactive metal ions conjugated sPA hybrid structures are further used to develop antibacterial materials. It is due to the excellent antibacterial activity of zinc ions that the growth of clinically relevant bacteria such as E. Coli was inhibited in the presence of zinc-sPA conjugate. The bacterial test demonstrated that owing to high biocompatibility with bacterial cell, the designed sPA worked as metal ions delivery agent and therefore it can show great potential in locally addressing bacterial infections. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Influence of silver on photocatalytic activity of TiO2

    International Nuclear Information System (INIS)

    Kisen, Carla Yuri; Teodoro, Vinicius; Zaghete, Maria Ap.; Perazolli, Leinig Antonio; Longo, Elson

    2016-01-01

    Full text: This work studied the influence of silver on photo activity of TiO 2 , prepared by Pechini method, in the photodegradation of Rhodamine-B. The catalysts were prepared with different percentage of silver (0.0, 0.5 and 1.0 %) and different calcination temperatures (500, 600 and 700°C), characterized by X-ray diffraction (DRX) and field emission gun - scanning electron microscopy (FEG-SEM), The powders' photo catalytic activity was defined by Rhodamine-B decolorisation test. The solution containing the dye and the catalyst, in the concentration of 0,01 mmol L -1 e 1,0 g L -1 respectively, were submitted to radiation with 9W germicidal lamp for 120 minutes. The control samples, for comparison effects, were made with TiO 2 anatase (Synth brand) and photolysis tests. In the micrographs, obtained by SEM, all the temperatures and compositions employed presented similar morphologies, it is assumed the calcination temperature rise leads to a decreased apparent porosity and the generation of particles clusters. The X-ray diffractograms indicates the calcination temperature influence in the generation of distinct TiO 2 phases during the catalysts synthesis. Regardless of the TiO 2 proportions, the only actual phase with 500°C calcination is the anatase. At 600°C, the rutile phase coexisting with the anatase phase disappears, and the rutile phase predominates. Among the catalysts, what presented greater activity was the TiO 2 with 0.5% Ag and calcination temperature of 500°C, which degraded around 100% in 60 minutes. References: [1] P. Cozolli, E. Fanizza and A. Agostiano. J. Phys.Chem. B108, 9623-9630, 2004. (author)

  6. Influence of Microtexture on Early Plastic Slip Activity in Ti-6Al-4V Polycrystals

    Science.gov (United States)

    Hémery, Samuel; Dang, Van Truong; Signor, Loïc; Villechaise, Patrick

    2018-06-01

    Microtextured regions are known to influence the fatigue performance of titanium alloys. Previous studies revealed that crack initiation, accounting for most of the fatigue life, is triggered by slip activity. The influence of microtextured regions on the early plastic slip activity was presently investigated by means of an in situ tensile test performed inside a scanning electron microscope on a bimodal Ti-6Al-4V polycrystalline specimen. A slip trace analysis was carried out in several regions with different crystallographic textures to highlight potentially different deformation behaviors. Significant stress heterogeneities were revealed through an early slip activation in microtextured regions with a predominant [0001] orientation. This point was shown to be related to a locally increased resolved shear stress. Consequences on behavior under cyclic loadings are finally discussed.

  7. [The influence of variable and constant magnetic fields on biota and biological activity of ordinary chernozem soils].

    Science.gov (United States)

    Denisova, T V; Kazeev, K Sh

    2007-01-01

    In model experiments on influence variable magnetic fields of industrial frequency (50 Hz) an induction of 1500 and of 6000 mkTl and the constant magnetic field an induction of 6000 mkTl and of 15000 mkTl during 5 days of exposure on biological properties of chernozem ordinary is shown, that the soil microflora is more sensitive to magnetic fields, than enzymes activity. Bacteria are more sensitive, than microscopic mushrooms. Dehydrogenase it is steady against influence of all variants. Constant magnetic field by the induction of 15000 mkTl rendered practically identical authentic overwhelming influence on catalase and saccharase activity - on 51 and 47% accordingly.

  8. Influence Factors of Sexual Activity for Internal Migrants in China

    Directory of Open Access Journals (Sweden)

    Junguo Zhang, PhD candidate

    2018-06-01

    indicate that specific demographic, socioeconomic, and epidemiological characteristics influenced sexual frequency among migrants. Sexual communication as the largest effect predictor to sexual frequency should be paid more attention to, to improve sexual activity of migrants.Zhang J, Wu J, Li Y, et al. Influence factors of sexual activity for internal migrants in China. J Sex Med 2018;6:97–107. Key Words: Sexual Activity, Influence Factors, Migrants, China, Quantile Regression

  9. Activation of ERK2 in basolateral amygdala underlies the promoting influence of stress on fear memory and anxiety: influence of midazolam pretreatment.

    Science.gov (United States)

    Maldonado, N M; Espejo, P J; Martijena, I D; Molina, V A

    2014-02-01

    Exposure to emotionally arousing experiences elicits a robust and persistent memory and enhances anxiety. The amygdala complex plays a key role in stress-induced emotional processing and in the fear memory formation. It is well known that ERK activation in the amygdala is a prerequisite for fear memory consolidation. Moreover, stress elevates p-ERK2 levels in several areas of the brain stress circuitry. Therefore, given that the ERK1/2 cascade is activated following stress and that the role of this cascade is critical in the formation of fear memory, the present study investigated the potential involvement of p-ERK2 in amygdala subnuclei in the promoting influence of stress on fear memory formation and on anxiety-like behavior. A robust and persistent ERK2 activation was noted in the Basolateral amygdala (BLA), which was evident at 5min after restraint and lasted at least one day after the stressful experience. Midazolam, a short-acting benzodiazepine ligand, administered prior to stress prevented the increase in the p-ERK2 level in the BLA. Pretreatment with intra-BLA infusion of U0126 (MEK inhibitor), but not into the adjacent central nucleus of the amygdala, attenuated the stress-induced promoting influence on fear memory formation. Finally, U0126 intra-BLA infusion prevented the enhancement of anxiety-like behavior in stressed animals. These findings suggest that the selective ERK2 activation in BLA following stress exposure is an important mechanism for the occurrence of the promoting influence of stress on fear memory and on anxiety-like behavior. © 2013 Published by Elsevier B.V. and ECNP.

  10. Perceptions, Expectations, and Informal Supports Influence Exercise Activity in Frail Older Adults

    Directory of Open Access Journals (Sweden)

    Louise Broderick

    2015-04-01

    Full Text Available This study aims to explore frail older adults’ perceptions of what influences their exercise behaviors. A qualitative descriptive design was used. Semi-structured, open-ended interviews were conducted with 29 frail older adults. Thematic content analysis established the findings. Frail older adults perceive exercise as a by-product of other purposeful activities such as manual work or social activities. Progression into frailty appears to be associated with a decline in non-family support, changing traditional roles within family support networks, and lower baseline activity levels. Frail older adults perceive exercise as incidental to more purposeful activities rather than an endpoint in itself. Therefore, exercise programs concentrating on functional outcomes may be more relevant for this population. Strategies that educate and promote social support networks may also benefit frail older adults.

  11. Influence of experimental occlusal discrepancy on masticatory muscle activity during clenching.

    Science.gov (United States)

    Baba, K; Ai, M; Mizutani, H; Enosawa, S

    1996-01-01

    The influence of the experimental occlusal discrepancy on masticatory muscle activity was investigated on 12 subjects. Specially designed occlusal interferences were fabricated and various occlusal states were simulated with their aid. Subjects were asked to carry out eccentric clenching efforts and electromyographic activity of the masseter plus the anterior and posterior temporal muscles was measured. When compared with clenching on the unaltered natural dentition, clenching on the experimental interferences resulted in distinct patterns in the jaw elevator muscles, and the most characteristic change was observed when clenching effort was exerted on the experimental non-working side interference. Electromyographic activity in the anterior and posterior temporal muscles was decreased on the working side and increased on the non-working side and originally unilateral activity pattern with clear dominance on the working side was altered to a bilateral pattern, while that of the masseter muscles remained uninfluenced. Resultant bilateral activity in the anterior and posterior temporal muscles is thought to cause a superior movement of the working side condyle and an inferior movement of the non-working side condyle.

  12. Investigation on the movements and the distributions of radon, thoron and their decay nuclides on the life circumstances

    International Nuclear Information System (INIS)

    Morishima, Hiroshige; Koga, Taeko

    2001-03-01

    UNSCEAR (2000) reported that the effective doses due to the inhalation of radon and its decay nuclides account on average of the all world for about one-half of all natural sources of radiation. These have great influences on various forms as the sources of terrecial environmental γ radiation and of radon on our life circumstances. Radon and thoron, which are natural gaseous radioactive nuclides released out of rocks and soil etc. are chemical inert and electrically uncharged, but they in the air can spontaneously decay to other metal atoms. And they made a wide fluctuation seasonally and spatially on the environment, but these are not uniformly. We have selected and observed on Misasa spa district, Tottori pref., Kawanishi-shi, Hyogo pref. and Masutomi spa, Yamanashi pref., for HBRA, and Higashi-osaka-shi, Osaka pref., for CA. We have carried out the study on the environmental movement and distribution of natural radioactive nuclides containing radon, thoron and their decay nuclides, and reported these results on following; (1) Radon measurements have been carried using a small pico-rad detector and many sampling points and Pilon scintillation-cell with 300 ml volume by grub sampling. Mean radon concentrations of get briefly for 24 hours are measured to be available on draw of the concentration distribution map. (2) We continued time cource variation of mean radon concentrations on same private house of Misasa spa district. Mean radon concentrations in air for 6 years were fluctuated 6.7-50 Bq/m 3 and 23-170 Bq/m 3 indoor. The mean concentrations on summer and rain season is low level at open-door situation and that on winter is high, as same as these on Kawanishi Hyogo pref.. It was shown that radon outdoor concentrations variation in time course almost have a similar tendency with indoor and the life situation of air ventilation and conditioning are more influenced than variation on area condition. (3) Radon concentrations on Masutomi spa districts, Yamanashi

  13. Influence of acid phosphatase activity on the saccharification of potato maltodextrins by Aspergillus niger glucoamylase

    Energy Technology Data Exchange (ETDEWEB)

    Zyla, K. (Akademia Rolnicza, Cracow (Poland). Dept. of Biotechnology)

    1990-01-01

    A preparation of Aspergillus niger acid phosphatase, which had the temperature optimum 60deg C, pH optimum 1.8-3.0; good stability at pH 4-5, the ability to hydrolyze glucose-6-phosphate at a high rate, and substantial lack of glucogenic activities, was used simultaneously with a glucoamylase in order to learn its influence on the saccharification of potato maltodextrins. The addition of the acid phosphatase activity in amounts that gave the 50 fold increase, as compared to phosphatase activity which naturally occurs in the gluocoamylase (GA) preparation 'AMG-200', was found to influence on the DE level, mainly at the high substrate concentration (40% d.s.) and low glucoamylase dosage (60-100 GAU/kg d.s.). It may also be possible, when using the acid phosphatase addition, to shorten the saccharification time. (orig.).

  14. Genotypic and climatic influence on the antioxidant activity of flavonoids in Kale (Brassica oleracea var. sabellica).

    Science.gov (United States)

    Zietz, Michaela; Weckmüller, Annika; Schmidt, Susanne; Rohn, Sascha; Schreiner, Monika; Krumbein, Angelika; Kroh, Lothar W

    2010-02-24

    The influence of genotype and climatic factors, e.g. mean temperature and mean global radiation level, on the antioxidant activity of kale was investigated. Therefore, eight kale cultivars, hybrid and traditional, old cultivars, were grown in a field experiment and harvested at four different times. In addition to the investigation of the total phenolic content, the overall antioxidant activity was determined by TEAC assay and electron spin resonance spectrometry. A special aim was to characterize the contribution of single flavonoids to the overall antioxidant activity using an HPLC-online TEAC approach. The antioxidant activity and the total phenolic content were influenced by the genotype and the eco-physiological factors. The HPLC-online TEAC results showed that not all flavonol glycosides contribute to the overall antioxidant activity in the same manner. Taking the results of the structural analysis obtained by HPLC-ESI-MS(n) into account, distinct structure-antioxidant relationships have been observed.

  15. Available processing resources influence encoding-related