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Sample records for activation utilizing auto-catalytic

  1. LASER INDUCED SELECTIVE ACTIVATION UTILIZING AUTO-CATALYTIC ELECTROLESS PLATING ON POLYMER SURFACE

    DEFF Research Database (Denmark)

    Zhang, Yang; Nielsen, Jakob Skov; Tang, Peter Torben

    2009-01-01

    . Characterization of the deposited copper layer was used to select and improve laser parameters. Several types of polymers with different melting points were used as substrate. Using the above mentioned laser treatment, standard grades of thermoplastic materials such as ABS, SAN, PE, PC and others have been......This paper presents a new method for selective micro metallization of polymers induced by laser. An Nd: YAG laser was employed to draw patterns on polymer surfaces using a special set-up. After subsequent activation and auto-catalytic electroless plating, copper only deposited on the laser tracks....... Induced by the laser, porous and rough structures are formed on the surface, which favours the palladium attachment during the activation step prior to the metallization. Laser focus detection, scanning electron microscopy (SEM) and other instruments were used to analyze the topography of the laser track...

  2. The influence of platinum washing-out time on its recovery from used auto catalytic converters

    Directory of Open Access Journals (Sweden)

    A. Fornalczyk

    2014-07-01

    Full Text Available The used catalytic converters contain small amounts of precious metals. Recovery of these metals is essential for environmental and economic reasons. This work presents a method of Platinum Group Metals (PGM recovery from auto catalytic converters in which they are washed out by a liquid metal. The magneto-hydro-dynamic pump was used to force circulation of liquid metal under the influence of electromagnetic fields The influence of process time on platinum recovery was also carried out.

  3. State of the art on hydrogen passive auto-catalytic recombiner (european union Parsoar project)

    Energy Technology Data Exchange (ETDEWEB)

    Arnould, F.; Bachellerie, E. [Technicatome, 13 - Aix en Provence (France); Auglaire, M. [Tractebel Energy Engineering, Brussels (Belgium); Boeck, B. de [Association Vincotte Nuclear, Brussels (Belgium); Braillard, O. [CEA Cadarache, 13 - Saint Paul lez Durance (France); Eckardt, B. [Siemens AG, Offenbach am Main (Germany); Ferroni, F. [Electrowatt Engineering Limited, Zurich (Switzerland); Moffett, R. [Atomic Energy Canada Limited, Pinawa (Canada); Van Goethem, G. [European Commission, Brussels (Belgium)

    2001-07-01

    This paper presents an overview of the European Union PARSOAR project, which consists in carrying out a state of the art on hydrogen passive auto-catalytic recombiner (PAR) and a handbook guide for implementing these devices in nuclear power plants. This work is performed in the area ''Operational Safety of Existing Installations'' of the key action ''Nuclear Fission'' of the fifth Euratom Framework Programme (1998-2002). (author)

  4. Reliability Tests of Aluminium Wedge Wire Bonding on Auto-catalytic Silver Immersion Gold (ASIG) PCB Metallization

    CERN Document Server

    Drozd, A; Kaufmann, S; Manolescu, F; McGill, I

    2011-01-01

    The Auto-catalytic Silver Immersion Gold (ASIG) PCB metallization is a new process that has clear advantages for PCB assembly especially with regard to lead-free soldering. As it may become a popular process in the future for electronics used in physics experiments, the quality of this metallization for aluminium wire bonding has been studied. Aluminium wedge wire bonding continues to be the interconnection method of choice for many physics detector sensors, for high density signal routing and for unpackaged die. Although advertised as having good quality for aluminium wire bonding, this study was performed to verify this claim as well as to test the longer term reliability of the wire bonds taking into consideration the environmental conditions and life-expectancy of devices, in particular for high energy physics detector applications. The tests were performed on PCBs made with the ASIG and ENIG (Electro-less Nickel Immersion Gold) processes at the same time in order to make a comparison with the current ind...

  5. Vapour Treatment Method Against Other Pyro- and Hydrometallurgical Processes Applied to Recover Platinum From Used Auto Catalytic Converters

    Institute of Scientific and Technical Information of China (English)

    Agnieszka FORNALCZYK; Mariola SATERNUS

    2013-01-01

    Today more and more cars are produced every year.All of them have to be equipped with catalytic converters,the main role of which is to obtain substances harmless to the environment instead of exhausted gases.Catalytic converters contain platinum group metals (PGM) especially platinum,palladium and rhodium.The price of these metals and their increasing demand are the reasons why today it is necessary to recycle used auto catalytic converters.There are many available methods of recovering PGM metals from them,especially platinum.These methods used mainly hydrometallurgical processes; however pyrometallurgical ones become more and more popular.The article presents results of the research mainly concerning pyrometallurgical processes.Two groups of research were carried out.In the first one different metals such as lead,magnesium and copper were used as a metal collector.During the tests,platinum went to those metals forming an alloy.In other research metal vapours were blown through catalytic converter carrier (grinded or whole).In the tests metals such as calcium,magnesium,cadmium and zinc were applied.As a result white or grey powder (metal plus platinum) was obtained.The tables present results of the research.Processing parameters and conclusions are also shown.To compare efficiency of pyrometallurgical and hydrometallurgical methods catalytic converter carrier and samples of copper with platinum obtained from pyrometallurgical method were solved in aqua regia,mixture of aqua regia and fluoric acid.

  6. An Auto-Catalytic Surface for Conformational Replication of Amyloid Fibrils—Genesis of an Amyloid World?

    Science.gov (United States)

    Hammarström, Per; Ali, Malik M.; Mishra, Rajesh; Salagic, Belma; Svensson, Samuel; Tengvall, Pentti; Lundström, Ingemar

    2011-08-01

    Amyloid fibrils are composed of self assembled stacked peptide or protein molecules folded and trapped in a stable cross-beta-sheet conformation. The amyloid fibrillation mechanism represents an intriguing self-catalyzed process rendering replication of a molecular conformational memory of interest for prebiotic chemistry. Herein we describe how a solid surface can be rendered auto-catalytic for fibrillation of a protein solution. We have discovered that a hydrophobic silicon or glass surface can be made to continuously fibrillate solutions of insulin monomers under stressed conditions (pH 1.6, 65°C). It was found that the surface acts as a platform for the formation of nascent seeds that induce fibril replication on and at the surface. This autocatalytic effect stems from a layer a few insulin molecules thick representing an oligomeric layer of misfolded, conformationally trapped, insulin molecules that rapidly through epitaxial growth catalyze the rate determining step (nucleation) during fibril replication. This autocatalytic layer is generated by the protein-solid surface interaction and conformational changes of the adsorbed protein during exposure at the air-water interface. The resulting autocatalytic surface thus both initiates local conformational molecular self-replication and acts as a reservoir for fibril seeds budding off into solution spreading fibril replication entities to the surrounding medium. The possibility of catalysis of the conformational replication process by minute amounts of nucleation sites located on a recruiting surface can evade the issue of dramatic concentration dependence of amyloidogenesis.

  7. Substrate utilization during exercise in active people.

    Science.gov (United States)

    Coyle, E F

    1995-04-01

    When people walk at low intensity after fasting, the energy needed is provided mostly by oxidation of plasma fatty acids. As exercise intensity increases (eg, to moderate running), plasma fatty acid turnover does not increase and the additional energy is obtained by utilization of muscle glycogen, blood glucose, and intramuscular triglyceride. Further increases in exercise intensity are fueled mostly by increases in muscle glycogen utilization with some additional increase in blood glucose oxidation. Muscle glycogen and blood glucose contribute equally to carbohydrate energy production over 2-3 h of moderate-intensity exercise; fatigue develops when these substrates are depleted. Active people can deplete muscle glycogen with 30-60 min of high intensity, intermittent exercise. When the ingestion of dietary carbohydrate is optimal, it is possible to resynthesize muscle glycogen to high concentrations in approximately 24 h, which is the major factor in recovery of exercise tolerance. However, this requires that a 70-kg person eat at least 50 g carbohydrate per every 2 h, beginning soon after exercise, and ingest 500-600 g in 24 h (ie; approximately 7-9 g/kg body wt). Carbohydrate foods eliciting high glycemic and insulinemic responses promote more rapid glycogen resynthesis than do foods eliciting lower glycemic responses. Therefore, foods ingested for energy before, during, or after exercise should be classified according to their glycemic index. Although carbohydrate ingestion before and during exercise adds exogenous substrate to the body, it usually attenuates plasma fatty acid mobilization and oxidation.

  8. Substrate utilization and VSS relations in activated sludge processes

    Energy Technology Data Exchange (ETDEWEB)

    Droste, R.L.; Fernandes, L.; Sun, X. [Ottawa Univ., ON (Canada). Dept. of Civil Engineering

    1993-12-31

    A new empirical substrate removal model for activated sludge in continuous flow stirred tank reactor (CFSTR) and sequencing batch reactor (SBR) was developed in this study. This model includes an exponential function of volatile suspended solids to express the active biomass which is actually involved in substrate utilization. Results indicate that the proposed exponential models predict more accurately effluent COD in CFSTR and SBR systems than the first or zero order models. (author). 7 refs., 1 fig., 4 tabs.

  9. Phytate phosphorus utilization and intestinal phytase activity in laying hens

    Directory of Open Access Journals (Sweden)

    Alaeldein M. Abudabos

    2012-01-01

    Full Text Available The first aim of this study was to examine the effects of strain and age on phytate phosphorus (PP utilization and intestinal phytase activity (IPA in two strains of laying hens, Hy-line Brown (HB and Hy-line White W-36 (HW at 32, 52 and 72 weeks of age. A digestion trial was conducted using the indicator method and birds were sampled to measure IPA. The second aim was to examine the effect of feed grade exogenous phytase enzyme on total (TP, water soluble (WSP and phytate phosphorus (PP excretion in the HW strain fed varying levels of phosphorus. Hens were fed three concentrations of available P (AP: 0.2, 0.3 and 0.4%. Each level of P was supplemented with three levels of commercial feed grade exogenous phytase enzyme (0, 300, and 600 FTU/kg and the amount of TP, WSP and PP in excreta per 100 g of feed consumed was calculated. The HB retained more PP as compared to HW. Intestinal phytase activity showed a significant (P<0.01 age effect with the highest activity occurring at 32 weeks. There were significant differences in the amount of TP and SP excreted between birds receiving the 3 levels of phosphorus with 300 units phytase (P<0.01. The results of this study showed that layers are capable of utilizing PP, and that utilization is regulated by IPA and varies with age. Exogenous phytase improved PP utilization but it increased the amount of TP and WSP in excreta.

  10. Current activities handbook: formerly utilized sites remedial action program

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-02-27

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the activities each of the thirteen state legislatures potentially affected by the Formerly Utilized Sites Remedial Action Program. It contains a description of the state legislative procedural rules and a schedule of each legislative session; a summary of pending relevant legislation; the name and telephone number of legislative and state agency contacts; and the full text of all bills identified.

  11. Early oxygen-utilization and brain activity in preterm infants.

    Directory of Open Access Journals (Sweden)

    Maria Luisa Tataranno

    Full Text Available The combined monitoring of oxygen supply and delivery using Near-InfraRed spectroscopy (NIRS and cerebral activity using amplitude-integrated EEG (aEEG could yield new insights into brain metabolism and detect potentially vulnerable conditions soon after birth. The relationship between NIRS and quantitative aEEG/EEG parameters has not yet been investigated. Our aim was to study the association between oxygen utilization during the first 6 h after birth and simultaneously continuously monitored brain activity measured by aEEG/EEG. Forty-four hemodynamically stable babies with a GA < 28 weeks, with good quality NIRS and aEEG/EEG data available and who did not receive morphine were included in the study. aEEG and NIRS monitoring started at NICU admission. The relation between regional cerebral oxygen saturation (rScO2 and cerebral fractional tissue oxygen extraction (cFTOE, and quantitative measurements of brain activity such as number of spontaneous activity transients (SAT per minute (SAT rate, the interval in seconds (i.e. time between SATs (ISI and the minimum amplitude of the EEG in μV (min aEEG were evaluated. rScO2 was negatively associated with SAT rate (β=-3.45 [CI=-5.76- -1.15], p=0.004 and positively associated with ISI (β=1.45 [CI=0.44-2.45], p=0.006. cFTOE was positively associated with SAT rate (β=0.034 [CI=0.009-0.059], p=0.008 and negatively associated with ISI (β=-0.015 [CI=-0.026- -0.004], p=0.007. Oxygen delivery and utilization, as indicated by rScO2 and cFTOE, are directly related to functional brain activity, expressed by SAT rate and ISI during the first hours after birth, showing an increase in oxygen extraction in preterm infants with increased early electro-cerebral activity. NIRS monitored oxygenation may be a useful biomarker of brain vulnerability in high-risk infants.

  12. Magnetic activated cell sorting (MACS): utility in assisted reproduction.

    Science.gov (United States)

    Makker, Kartikeya; Agarwal, Ashok; Sharma, Rakesh K

    2008-07-01

    Assisted reproductive techniques (ART) have now been extensively incorporated in the management of infertile couples. But even after rapid methodological and technological advances the success rates of these procedures have been below expectations. This has led to development of many sperm preparation protocols to obtain an ideal semen sample for artificial reproduction. Sperm apoptosis has been heavily linked to failures in reproductive techniques. One of the earliest changes shown by apoptotic spermatozoa is externalization of phosphatidyl serine. Magnetic activated cell sorting (MACS) is a novel sperm preparation technique that separates apoptotic and non-apoptotic spermatozoa based on the expression of phosphatidylserine. This has led to the incorporation of MACS as a sperm preparation technique. The review highlights the principle and mechanism of this novel technique and enumerates its advantages as a sperm preparation technique. Its utility in ART as an efficient tool for sperm recovery and its application in cryopreservation of semen samples is also explained.

  13. Learning Activities Utilized and Readiness for the Student Teaching Internship

    Science.gov (United States)

    Stripling, Christopher T.; Thoron, Andrew C.; Estepp, Christopher M.

    2014-01-01

    Agricultural education has traditionally provided rich learning experiences for secondary school students; however, less attention has been paid to the learning experiences preservice agricultural education teachers utilize and provide secondary school students during the student teaching internship. This study sought to describe the learning…

  14. Research activities to improve the utilization of antibiotics in Africa.

    Science.gov (United States)

    Massele, Amos; Tiroyakgosi, Celda; Matome, Matshediso; Desta, Abayneh; Muller, Arno; Paramadhas, Bene D Anand; Malone, Brighid; Kurusa, Gobuiwang; Didimalang, Thatayaone; Moyo, Mosana; Godman, Brian

    2017-02-01

    There is a need to improve the rational use of antibiotics across continents including Africa. This has resulted in initiatives in Botswana including treatment guidelines and the instigation of Antibiotic Stewardship Programs (ASPs). The next steps involve a greater understanding of current antibiotic utilization and resistance patterns (AMR). This resulted in a 2-day meeting involving key stakeholders principally from Botswana to discuss key issues including AMR rates as well as ASPs in both the public and private sectors. Following this, the findings will be used to plan future studies across Africa including point prevalence studies. The findings will be presented in July 2016 at the next Medicines Utilization Research in Africa meeting will ideally serve as a basis for planning future pertinent interventional studies to enhance the rational use of antibiotics in Botswana and wider.

  15. Utilizing the Bicycle for Non-Traditional Activities

    Science.gov (United States)

    Maina, Michael P.; Maina, Julie Schlegel; Sebek, Ludek; Hoffmanova, Jana; Kane, Jennifer Jackson

    2012-01-01

    This article examines the bicycle as not simply a means of transportation or as an exercise device, but rather as a vehicle for teambuilding and problem solving activities within a physical education curriculum. The activities described in this article focus on bike-centered initiatives that foster creative problem solving. They have universal…

  16. Utilization of Mineral Wools as Alkali-Activated Material Precursor

    Directory of Open Access Journals (Sweden)

    Juho Yliniemi

    2016-04-01

    Full Text Available Mineral wools are the most common insulation materials in buildings worldwide. However, mineral wool waste is often considered unrecyclable because of its fibrous nature and low density. In this paper, rock wool (RW and glass wool (GW were studied as alkali-activated material precursors without any additional co-binders. Both mineral wools were pulverized by a vibratory disc mill in order to remove the fibrous nature of the material. The pulverized mineral wools were then alkali-activated with a sodium aluminate solution. Compressive strengths of up to 30.0 MPa and 48.7 MPa were measured for RW and GW, respectively, with high flexural strengths measured for both (20.1 MPa for RW and 13.2 MPa for GW. The resulting alkali-activated matrix was a composite-type in which partly-dissolved fibers were dispersed. In addition to the amorphous material, sodium aluminate silicate hydroxide hydrate and magnesium aluminum hydroxide carbonate phases were identified in the alkali-activated RW samples. The only crystalline phase in the GW samples was sodium aluminum silicate. The results of this study show that mineral wool is a very promising raw material for alkali activation.

  17. ECUT: Energy Conversion and Utilization Technologies program - Biocatalysis research activity

    Science.gov (United States)

    Wilcox, R.

    1984-01-01

    The activities of the Biocatalysis Research Activity are organized into the Biocatalysis and Molecular Modeling work elements and a supporting planning and analysis function. In the Biocatalysis work element, progress is made in developing a method for stabilizing genetically engineered traits in microorganisms, refining a technique for monitoring cells that are genetically engineered, and identifying strains of fungi for highly efficient preprocessing of biomass for optimizing the efficiency of bioreactors. In the Molecular Modeling work element, a preliminary model of the behavior of enzymes is developed. A preliminary investigation of the potential for synthesizing enzymes for use in electrochemical processes is completed. Contact with industry and universities is made to define key biocatalysis technical issues and to broaden the range of potential participants in the activity. Analyses are conducted to identify and evaluate potential concepts for future research funding.

  18. Utilizing Wisconsin Afterschool Programs to Increase Physical Activity in Youth

    Science.gov (United States)

    Cavanagh, Bradley D.; Meinen, Amy

    2015-01-01

    Background: Approximately 31.7% of children in the United States are overweight or obese. Interventions in the afterschool setting may help combat childhood obesity. Research exists on interventions in school settings, but a few data exist for interventions about afterschool programs. This study investigates increasing physical activity (PA) in…

  19. Early Oxygen-Utilization and Brain Activity in Preterm Infants

    NARCIS (Netherlands)

    Tataranno, ML; Alderliesten, Thomas; De Vries, Linda S.; Groenendaal, Floris; Toet, MC; Lemmers, Petra M A; van de Vosse, R.; Van Bel, Frank; Benders, Manon J N L

    2015-01-01

    The combined monitoring of oxygen supply and delivery using Near-InfraRed spectroscopy (NIRS) and cerebral activity using amplitude-integrated EEG (aEEG) could yield new insights into brain metabolism and detect potentially vulnerable conditions soon after birth. The relationship between NIRS and qu

  20. Development of HANARO Activation Analysis System and Utilization Technology

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Y. S.; Moon, J. H.; Cho, H. J. (and others)

    2007-06-15

    1. Establishment of evaluation system using a data for a neutron activation analysis : Improvement of NAA measurement system and its identification, Development of combined data evaluation code of NAA/PGAA, International technical cooperation project 2. Development of technique for a industrial application of high precision gamma nuclide spectroscopic analysis : Analytical quality control, Development of industrial application techniques and its identification 3. Industrial application research for a prompt gamma-ray activation analysis : Improvement of Compton suppression counting system (PGAA), Development of applied technology using a PGAA system 4. Establishment of NAA user supporting system and KOLAS management : Development and validation of KOLAS/ISO accreditation testing and identification method, Cooperation researches for a industrial application, Establishment of integrated user analytical supporting system, Accomplishment of sample irradiation facility.

  1. Electroless Plating on Plastic Induced by Selective Laser Activation

    DEFF Research Database (Denmark)

    Zhang, Yang; Tang, Peter Torben; Hansen, Hans Nørgaard

    2009-01-01

    This paper presents a new method for selective micro metallization of polymers. A Nd:YAG laser is employed to draw patterns on polymer surfaces that are submerged in a liquid (usually water). After subsequent activation with palladium chloride and followed by auto-catalytic electroless plating...... in width with 50μm between two tracks, but further optimization is expected in this field. Due to the porous and rough structure of the laser track, excellent adhesion between metallization and substrate is obtained. On top of the first copper layer, additional metal such as nickel, gold, palladium or tin...

  2. Stock price change rate prediction by utilizing social network activities.

    Science.gov (United States)

    Deng, Shangkun; Mitsubuchi, Takashi; Sakurai, Akito

    2014-01-01

    Predicting stock price change rates for providing valuable information to investors is a challenging task. Individual participants may express their opinions in social network service (SNS) before or after their transactions in the market; we hypothesize that stock price change rate is better predicted by a function of social network service activities and technical indicators than by a function of just stock market activities. The hypothesis is tested by accuracy of predictions as well as performance of simulated trading because success or failure of prediction is better measured by profits or losses the investors gain or suffer. In this paper, we propose a hybrid model that combines multiple kernel learning (MKL) and genetic algorithm (GA). MKL is adopted to optimize the stock price change rate prediction models that are expressed in a multiple kernel linear function of different types of features extracted from different sources. GA is used to optimize the trading rules used in the simulated trading by fusing the return predictions and values of three well-known overbought and oversold technical indicators. Accumulated return and Sharpe ratio were used to test the goodness of performance of the simulated trading. Experimental results show that our proposed model performed better than other models including ones using state of the art techniques.

  3. Stock Price Change Rate Prediction by Utilizing Social Network Activities

    Science.gov (United States)

    Mitsubuchi, Takashi; Sakurai, Akito

    2014-01-01

    Predicting stock price change rates for providing valuable information to investors is a challenging task. Individual participants may express their opinions in social network service (SNS) before or after their transactions in the market; we hypothesize that stock price change rate is better predicted by a function of social network service activities and technical indicators than by a function of just stock market activities. The hypothesis is tested by accuracy of predictions as well as performance of simulated trading because success or failure of prediction is better measured by profits or losses the investors gain or suffer. In this paper, we propose a hybrid model that combines multiple kernel learning (MKL) and genetic algorithm (GA). MKL is adopted to optimize the stock price change rate prediction models that are expressed in a multiple kernel linear function of different types of features extracted from different sources. GA is used to optimize the trading rules used in the simulated trading by fusing the return predictions and values of three well-known overbought and oversold technical indicators. Accumulated return and Sharpe ratio were used to test the goodness of performance of the simulated trading. Experimental results show that our proposed model performed better than other models including ones using state of the art techniques. PMID:24790586

  4. Stock Price Change Rate Prediction by Utilizing Social Network Activities

    Directory of Open Access Journals (Sweden)

    Shangkun Deng

    2014-01-01

    Full Text Available Predicting stock price change rates for providing valuable information to investors is a challenging task. Individual participants may express their opinions in social network service (SNS before or after their transactions in the market; we hypothesize that stock price change rate is better predicted by a function of social network service activities and technical indicators than by a function of just stock market activities. The hypothesis is tested by accuracy of predictions as well as performance of simulated trading because success or failure of prediction is better measured by profits or losses the investors gain or suffer. In this paper, we propose a hybrid model that combines multiple kernel learning (MKL and genetic algorithm (GA. MKL is adopted to optimize the stock price change rate prediction models that are expressed in a multiple kernel linear function of different types of features extracted from different sources. GA is used to optimize the trading rules used in the simulated trading by fusing the return predictions and values of three well-known overbought and oversold technical indicators. Accumulated return and Sharpe ratio were used to test the goodness of performance of the simulated trading. Experimental results show that our proposed model performed better than other models including ones using state of the art techniques.

  5. Thermally activated retainer means utilizing shape memory alloy

    Science.gov (United States)

    Grimaldi, Margaret E. (Inventor); Hartz, Leslie S. (Inventor)

    1993-01-01

    A retainer member suitable for retaining a gap filler placed in gaps between adjacent tile members is presented. One edge of the retainer member may be attached to the gap filler and another edge may be provided with a plurality of tab members which in an intermediate position do not interfere with placement or removal of the gap filler between tile members. The retainer member may be fabricated from a shape memory alloy which when heated to a specified memory temperature will thermally activate the tab members to predetermined memory positions engaging the tile members to retain the gap filler in the gap. This invention has particular application to the thermal tiles on space vehicles such as the Space Shuttle Orbiter.

  6. UTILITY OF MECHANISTIC MODELS FOR DIRECTING ADVANCED SEPARATIONS RESEARCH & DEVELOPMENT ACTIVITIES: Electrochemically Modulated Separation Example

    Energy Technology Data Exchange (ETDEWEB)

    Schwantes, Jon M.

    2009-06-01

    The objective for this work was to demonstrate the utility of mechanistic computer models designed to simulate actinide behavior for use in efficiently and effectively directing advanced laboratory R&D activities associated with developing advanced separations methods.

  7. Activity report on the utilization of research reactors. Japanese Fiscal Year, 1998

    Energy Technology Data Exchange (ETDEWEB)

    Toyoda, Masayuki; Koyama, Yoshimi [eds.] [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2000-03-01

    This is the second issue of the activity report on the utilization of research reactors in the fields of neutron beam experiments, neutron activation analysis, radioisotope production, etc., performed during Japanese Fiscal Year 1998 (April 1, 1998 - March 31, 1999). All reports in this volume were described by users from JAERI and also users from the other organizations, i.e., universities, national research institutes and private companies, who have utilized our research reactor utilization facilities for the purpose of the above studies. (author)

  8. Activity report on the utilization of research reactors. Japanese Fiscal Year, 1999

    Energy Technology Data Exchange (ETDEWEB)

    Toyoda, Masayuki [ed.] [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2001-03-01

    This is the second issue of the activity report on the utilization of research reactors in the fields of neutron beam experiments, neutron activation analysis, radioisotope production, etc., performed during Japanese Fiscal Year 1999 (April 1, 1999 - March 31, 2000). All reports in this volume were described by users from JAERI and also users from the other organizations, i.e., universities, national research institutes and private companies, who have utilized our research reactor utilization facilities for the purpose of the above studies. (author)

  9. Risk management activities of a non-industrial private forest owner with a bivariate utility function

    OpenAIRE

    Brunette, Marielle; Couture, Stéphane

    2014-01-01

    In this paper, we propose to analyse the choice of risk management activity made by a nonindustrial private forest owner who derives utility from consumption and from the sentimental value of the forest that bears a risk of disaster. We consider a bivariate utility function depending on consumption and sentimental value of forest. In this context, we analyse insurance and/or self-insurance decisions. We show that, under fair premium, full insurance is optimal only if the cross derivative of t...

  10. Research Activity in Computational Physics utilizing High Performance Computing: Co-authorship Network Analysis

    Science.gov (United States)

    Ahn, Sul-Ah; Jung, Youngim

    2016-10-01

    The research activities of the computational physicists utilizing high performance computing are analyzed by bibliometirc approaches. This study aims at providing the computational physicists utilizing high-performance computing and policy planners with useful bibliometric results for an assessment of research activities. In order to achieve this purpose, we carried out a co-authorship network analysis of journal articles to assess the research activities of researchers for high-performance computational physics as a case study. For this study, we used journal articles of the Scopus database from Elsevier covering the time period of 2004-2013. We extracted the author rank in the physics field utilizing high-performance computing by the number of papers published during ten years from 2004. Finally, we drew the co-authorship network for 45 top-authors and their coauthors, and described some features of the co-authorship network in relation to the author rank. Suggestions for further studies are discussed.

  11. An analysis of the factors influencing demand-side management activity in the electric utility industry

    Science.gov (United States)

    Bock, Mark Joseph

    Demand-side management (DSM), defined as the "planning, implementation, and monitoring of utility activities designed to encourage consumers to modify their pattern of electricity usage, including the timing and level of electricity demand," is a relatively new concept in the U.S. electric power industry. Nevertheless, in twenty years since it was first introduced, utility expenditures on DSM programs, as well as the number of such programs, have grown rapidly. At first glance, it may seem peculiar that a firm would actively attempt to reduce demand for its primary product. There are two primary explanations as to why a utility might pursue DSM: regulatory mandate, and self-interest. The purpose of this dissertation is to determine the impact these influences have on the amount of DSM undertaken by utilities. This research is important for two reasons. First, it provides insight into whether DSM will continue to exist as competition becomes more prevalent in the industry. Secondly, it is important because no one has taken a comprehensive look at firm-level DSM activity on an industry-wide basis. The primary data set used in this dissertation is the U.S. Department of Energy's Annual Electric Utility Report, Form EIA-861, which represents the most comprehensive data set available for analyzing DSM activity in the U.S. There are four measures of DSM activity in this data set: (1) utility expenditures on DSM programs; (2) energy savings by DSM program participants; and (3) the actual and (4) the potential reductions in peak load resulting from utility DSM measures. Each is used as the dependent variable in an econometric analysis where independent variables include various utility characteristics, regulatory characteristics, and service territory and customer characteristics. In general, the results from the econometric analysis suggest that in 1993, DSM activity was primarily the result of regulatory pressure. All of the evidence suggests that if DSM continues to

  12. Changes in enzymes activity, substrate utilization pattern and diversity of soil microbial communities under cadmium pollution

    Institute of Scientific and Technical Information of China (English)

    Muhammad Akmal; WANG Hai-zhen; WU Jian-jun; XU Jian-ming; XU De-fu

    2005-01-01

    Heavy metal pollution has received increasing attention in recent years mainly because of the public awareness of environmental issues. In this study we have evaluated the effect of cadmium(Cd) on enzymes activity, substrate utilization pattern and diversity of microbial communities in soil spiked with 0, 20, 40, 60, 80, and 100 mg/kg Cd, during 60 d of incubation at 25℃. Enzyme activities determined at 0, 15, 30, 45, and 60 d after heavy metal application(DAA) showed marked declines for various Cd treatments, and up to 60 DAA, 100 mg/kg Cd resulted in 50.1%, 47.4%, and 39.8 % decreases in soil urease, acid phosphatase and dehydrogenase activities,respectively to control. At 60 DAA, substrate utilization pattern of soil microbial communities determined by inoculating Biolog ECO plates indicated that Cd addition had markedly inhibited the functional activity of soil microbial communities and multivariate analysis of sole carbon source utilization showed significantly different utilization patterns for 80 and 100 mg/kg Cd treatments. The structural diversity of soil microbial communities assessed by PCR-DGGE method at 60 DAA, illustrated that DGGE patterns in soil simplified with increasing Cd concentration, and clustering of DGGE profiles for various Cd treatments revealed that they had more than 50% difference with that of control.

  13. Historical evolution of nuclear energy systems development and related activities in JAERI. Fission, fusion, accelerator utilization

    Energy Technology Data Exchange (ETDEWEB)

    Tone, Tatsuzo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2001-03-01

    Overview of the historical evolution of nuclear energy systems development and related activities in JAERI is given in the report. This report reviews the research and development for light water reactor, fast breeder reactor, high temperature gas reactor, fusion reactor and utilization of accelerator-based neutron source. (author)

  14. Student Perceptions of University Physical Activity Instruction Courses Taught Utilizing Sport Education

    Science.gov (United States)

    Mohr, Derek J.; Sibley, Benjamin A.; Townsend, J. Scott

    2012-01-01

    Limited research exists on effective teaching methods in university physical activity instruction (PAI) program courses. The purpose of this study was to evaluate PAI courses taught utilizing a sport education curriculum and instructional model. The Individual Development and Educational Assessment (IDEA) teaching evaluation was administered to…

  15. Utilizing Participatory Mapping and GIS to Examine the Activity Spaces of Homeless Youth.

    Science.gov (United States)

    Townley, Greg; Pearson, L; Lehrwyn, Josephine M; Prophet, Nicole T; Trauernicht, Mareike

    2016-06-01

    Although previous studies have informed our understanding of certain aspects of youth homelessness, few studies have critically examined the spatial and social environments utilized by youth as they navigate life on the streets. This study employed participatory mapping and Geographic Information Systems (GIS) to examine the activity spaces of homeless youth as they relate to sense of community and psychological well-being. Participants were 28 youth experiencing homelessness in Portland, Oregon, USA. Results suggest that youth engage most frequently in service-related activities, and their activity participation is significantly associated with sense of community and psychological well-being. The utility of innovative participatory methods for better understanding the diverse experiences of homeless youth is discussed alongside examination of their practical implications.

  16. Utility of Activated Nitriles in the Synthesis of Novel Heterocyclic Compounds with Antitumor Activity

    Directory of Open Access Journals (Sweden)

    Asmaa S. Salman

    2013-01-01

    Full Text Available Reaction of cyanoacetic acid hydrazide (1 with 4-methoxyacetophenone and 4-chlorobenzaldehyde (2a,b afforded the corresponding 2-cyanoacetohydrazide derivatives (3a,b respectively. The latter compounds were utilized as a key intermediate for the synthesis of new heterocyclic compounds. Newly synthesized compounds were characterized by elemental analyses and spectral data. The antitumor evaluation of some newly synthesized compounds was screened in vitro against human breast cancer cell line (MCF-7.

  17. Novel Optimization Method of Active Frequency Multiplier Utilizing Harmonic Terminating Impedances with DGS

    Directory of Open Access Journals (Sweden)

    M. Kasal

    2006-06-01

    Full Text Available A novel method for the optimization of the active frequency multiplier utilizing the harmonic terminating impedances with the defected ground structures (DGS has been developed. Furthermore, a new type of the low-pass filter with DGS for the higher harmonic suppression will be reported. Experimental conversion gains (14.52 dB for the doubler, 5.56 dB for the tripler and 0.43 dB for the quadrupler and real power-added efficiency (32.76 % for the doubler, 10.15 % for the tripler and 1.42 % for the quadrupler have been attained. To our knowledge, in the considered frequency range, these results represent the best performance reported up to date for the active frequency multipliers utilizing the low-cost BJTs.

  18. Active exercises utilizing a facilitating device in the treatment of lymphedema resulting from breast cancer therapy

    Directory of Open Access Journals (Sweden)

    de Fátima Guerreiro Godoy, Maria

    2010-01-01

    Full Text Available The aim of this study was to evaluate the reduction in volume of arm lymphedema secondary to breast cancer therapy utilizing an exercise facilitating device. Twenty-one women with arm lymphedema resulting from the surgical and radiotherapeutic treatment of breast cancer were randomly selected. Evaluation was made by water-displacement volumetry before and after each session. The patients were submitted to a series of active exercises using a facilitating device for four 12-minute sessions with intervals of 3 minutes between sessions in the sitting position with alignment of the spinal column. The lymphedematous arm was maintained under compression using a cotton-polyester sleeve. The active exercising device used was a mobile flexion bar fixed on a metal base at a height of 30 cm from the tabletop and at a distance of 10 cm from the patient’s body. The paired t-test was utilized for statistical analysis with an alpha error of 5% (p-value ≤0.05 being considered significant. The initial mean volume of the arms was 2,089.9 and the final volume was 2,023.0 mL with a mean loss of 66.9 mL (p-value <0.001. In conclusion, active exercises utilizing facilitating devices can contribute to a reduction in size of lymphedematous limbs.

  19. A Kluyveromyces marxianus 2-deoxyglucose-resistant mutant with enhanced activity of xylose utilization.

    Science.gov (United States)

    Suprayogi, Suprayogi; Nguyen, Minh T; Lertwattanasakul, Noppon; Rodrussamee, Nadchanok; Limtong, Savitree; Kosaka, Tomoyuki; Yamada, Mamoru

    2015-12-01

    Thermotolerant ethanologenic yeast Kluyveromyces marxianus is capable of fermenting various sugars including xylose but glucose represses to hamper the utilization of other sugars. To acquire glucose repression-defective strains, 33 isolates as 2-deoxyglucose (2-DOG)-resistant mutants were acquired from about 100 colonies grown on plates containing 2-DOG, which were derived from an efficient strain DMKU 3-1042. According to the characteristics of sugar consumption abilities and cell growth and ethanol accumulation along with cultivation time, they were classified into three groups. The first group (3 isolates) utilized glucose and xylose in similar patterns along with cultivation to those of the parental strain, presumably due to reduction of the uptake of 2-DOG or enhancement of its export. The second group (29 isolates) showed greatly delayed utilization of glucose, presumably by reduction of the uptake or initial catabolism of glucose. The last group, only one isolate, showed enhanced utilization ability of xylose in the presence of glucose. Further analysis revealed that the isolate had a single nucleotide mutation to cause amino acid substitution (G270S) in RAG5 encoding hexokinase and exhibited very low activity of the enzyme. The possible mechanism of defectiveness of glucose repression in the mutant is discussed in this paper. [Int Microbiol 18(4):235-244 (2015)].

  20. Gradient Descent Learning for Utility Current Compensation using Active Regenerative PWM Filter

    Directory of Open Access Journals (Sweden)

    R. Balamurugan

    2011-01-01

    Full Text Available Problem statement: Harmonic analysis is a primary matter of power quality assessment. Its main intention is to check the utility whether it is delivering the loads without any deviations in voltages and currents. The problem is due to proliferation of Electronic converters and power electronics which gave birth to numerous new applications, offering unmatched comfort to the customers. Approach: Harmonics should be maintained within the limits said in standards like IEEE 519 and others such as IEEE 1159 for safeguarding the utility. This was provided by many mitigation technologies like passive, shunt and series filtering, active conditioners, but they were lack of some demerits like huge cost, many controllers and circuit components. So for controlling the harmonic loads the converter with four quadrant characteristics was implemented and this converter act as shunt active filter as well as rectifier simultaneously without any additional circuitry. For having better harmonic reduction in addition, many controllers like p-q Theorem based controller, Fuzzy and gradient descent based neural network is also used. Results: The simulation results gives the compared source current wave forms for various controllers with individual harmonic mitigations. Conclusion: The pure utility current is obtained by using this intelligent neural filter without any additional components and without any extra controllers than the conventional methods.

  1. Development of a real time activity monitoring Android application utilizing SmartStep.

    Science.gov (United States)

    Hegde, Nagaraj; Melanson, Edward; Sazonov, Edward

    2016-08-01

    Footwear based activity monitoring systems are becoming popular in academic research as well as consumer industry segments. In our previous work, we had presented developmental aspects of an insole based activity and gait monitoring system-SmartStep, which is a socially acceptable, fully wireless and versatile insole. The present work describes the development of an Android application that captures the SmartStep data wirelessly over Bluetooth Low energy (BLE), computes features on the received data, runs activity classification algorithms and provides real time feedback. The development of activity classification methods was based on the the data from a human study involving 4 participants. Participants were asked to perform activities of sitting, standing, walking, and cycling while they wore SmartStep insole system. Multinomial Logistic Discrimination (MLD) was utilized in the development of machine learning model for activity prediction. The resulting classification model was implemented in an Android Smartphone. The Android application was benchmarked for power consumption and CPU loading. Leave one out cross validation resulted in average accuracy of 96.9% during model training phase. The Android application for real time activity classification was tested on a human subject wearing SmartStep resulting in testing accuracy of 95.4%.

  2. Prebiotic galactooligosaccharides activate mucin and pectic galactan utilization pathways in the human gut symbiont Bacteroides thetaiotaomicron

    Science.gov (United States)

    Lammerts van Bueren, Alicia; Mulder, Marieke; Leeuwen, Sander van; Dijkhuizen, Lubbert

    2017-01-01

    Galactooligosaccharides (GOS) are prebiotic carbohydrates that impart changes in the gut bacterial composition of formula-fed infants to more closely resemble that of breast-fed infants. Consuming human milk oligosaccharides (HMOs) provides specific bacterial strains with an advantage for colonizing the infant intestine. These same effects are seen in infants after GOS consumption, however GOS are very complex mixtures and the underlying molecular mechanisms of how GOS mimic HMOs are relatively unknown. Here we studied the effects of GOS utilization on a prominent gut symbiont, Bacteroides thetaiotaomicron, which has been previously shown to consume HMOs via mucin O-glycan degradation pathways. We show that several pathways for targeting O-mucin glycans are activated in B. thetaiotaomicron by GOS, as well as the galactan utilization sytem. Characterization of the endo-galactanase from this system identified activity on various longer GOS substrates while a subset of GOS compounds were identified as potential activators of mucin glycan metabolism in B. thetaiotaomicron. Our results show that GOS functions as an inducer of mucin-glycan pathways while providing a nutrient source in the form of β-(1 → 4)-galactan. These metabolic features of GOS mixtures may serve to explain the beneficial effects that are seen for GOS supplemented infant formula. PMID:28091546

  3. Prebiotic galactooligosaccharides activate mucin and pectic galactan utilization pathways in the human gut symbiont Bacteroides thetaiotaomicron.

    Science.gov (United States)

    Lammerts van Bueren, Alicia; Mulder, Marieke; Leeuwen, Sander van; Dijkhuizen, Lubbert

    2017-01-16

    Galactooligosaccharides (GOS) are prebiotic carbohydrates that impart changes in the gut bacterial composition of formula-fed infants to more closely resemble that of breast-fed infants. Consuming human milk oligosaccharides (HMOs) provides specific bacterial strains with an advantage for colonizing the infant intestine. These same effects are seen in infants after GOS consumption, however GOS are very complex mixtures and the underlying molecular mechanisms of how GOS mimic HMOs are relatively unknown. Here we studied the effects of GOS utilization on a prominent gut symbiont, Bacteroides thetaiotaomicron, which has been previously shown to consume HMOs via mucin O-glycan degradation pathways. We show that several pathways for targeting O-mucin glycans are activated in B. thetaiotaomicron by GOS, as well as the galactan utilization sytem. Characterization of the endo-galactanase from this system identified activity on various longer GOS substrates while a subset of GOS compounds were identified as potential activators of mucin glycan metabolism in B. thetaiotaomicron. Our results show that GOS functions as an inducer of mucin-glycan pathways while providing a nutrient source in the form of β-(1 → 4)-galactan. These metabolic features of GOS mixtures may serve to explain the beneficial effects that are seen for GOS supplemented infant formula.

  4. Synthetic utility of sydnones to couple pharmacologically important heterocycles for antitubercular activity

    Directory of Open Access Journals (Sweden)

    Tasneem Taj

    2014-12-01

    Full Text Available In the present investigation we have utilized the 3-arylsydnones 1a–c to couple two biodynamic moieties in amide derivatives 7–10. The 3-arylsydnones were brominated to 4-bromo-3-arylsydnones 2a–c which further were reacted with benzotriazole/benzothiazolin-2-thione/morpholine/diphenylamine to the corresponding final compounds. The structures of the amide derivatives were confirmed by the spectral (IR, 1H NMR and Mass and analytical data. Further, these were subjected to the antitubercular activity against Mycobacterium tuberculae (H37Rv. The morpholine 7a–c and benzotriazole 8a–c derivatives have exhibited good inhibition.

  5. Utilization of activated sludge plants for enhanced treatment of combined sewage.

    Science.gov (United States)

    Nikolavcic, B; Svardal, K; Wandl, G; Günther, N; Spatzierer, G

    2008-01-01

    A process is introduced which utilizes secondary clarifiers for the treatment of combined sewage. Under storm water conditions, surplus sewage bypasses the aeration tanks after primary treatment and is directly introduced into the secondary clarifiers. The hydraulic capacity of existing activated sludge plants can be increased without additional tank volume. Particulate matter as well as dissolved compounds are removed to a high extent. Investigations on a full scale treatment plant (100,000 p.e.) show that the effluent quality is comparable with full biological treatment, even if the hydraulic loading is increased by 50%. IWA Publishing 2008.

  6. Assessment of industrial activity in the utilization of biomass for energy

    Energy Technology Data Exchange (ETDEWEB)

    1980-09-01

    The objective of this report is to help focus the federal programs in biomass energy, by identifying the status and objectives of private sector activity in the biomass field as of mid-1979. In addition, the industry's perceptions of government activities are characterized. Findings and conclusions are based principally on confidential interviews with executives in 95 companies. These included forest products companies, agricultural products companies, equipment manufacturers, electric and gas utilities petroleum refiners and distributors, research and engineering firms, and trade organizations, as listed in Exhibit 1. Interview findings have been supplemented by research of recent literature. The study focused on four key questions: (1) what is the composition of the biomass industry; (2) what are the companies doing; (3) what are their objectives and strategies; and (4) what are the implications for government policy. This executive summary provides highlights of the key findings and conclusions. The summary discussion is presented in seven parts: (1) overview of the biomass field; (2) structure of the biomass industry today; (3) corporate activities in biomass-related areas; (4) motivations for these activities; (5) industry's outlook on the future for energy-from-biomass; (6) industry's view of government activities; and (7) implications for Federal policy.

  7. Phytochemical analysis and peripheral glucose utilization activity determination of Steblus asper

    Institute of Scientific and Technical Information of China (English)

    Monjoy Kumar Choudhury; S Venkatraman; Lokesh Upadhyay

    2012-01-01

    Objective: To investigate the anti-hyperglycemic and peripheral glucose utilization activity of petroleum ether extract of leafs of Streblus asper (SAPE) as well as to find out the hypoglycemic property of Apiol and its presence in the SAPE. Methods: The GCMS analysis was conducted to identify the Apiol present in the SAPE. Six groups of animals, containing six animals in each, were selected for this study. The first group served as control and provided only vehicle solution. Group second served as vehicle control and treated with 0.5% CMC (carboxy methyl cellulose) orally. Group third to sixth, were treated with glibemclamide (600 ug/kg bw) and SAPE 100 mg/kg bw, 250 mg/kg bw and 500 mg/kg bw respectively. In the second experiment, three groups of animals containing six animals in each were selected and were made diabetic as described earlier and simultaneously treated with pure Apiol at the dosages of 50 mg/kg bw, 75 mg/bw and 100 mg/kg bw respectively. Results: The GCMS analysis reviled the presence of Apiol molecules in the leaves of SAPE. Administration of SAPE and Apiol to the diabetic rats exhibited significant anti diabetic property (P<0.01). After 30 days of SAPE treatment, the fasting blood sugar levels of the diabetic rats were significantly reduced (P<0.001) along with restoration in their glycolytic and gluconeogenic enzyme activities, glycogen content and insulin level. Conclusions: The SAPE exhibited remarkable anti diabetic activity and excellent control over peripheral glucose utilization. Thus, it can be concluded that Apiol may be responsible for its anti-diabetic property.

  8. Substrate Utilization is Influenced by Acute Dietary Carbohydrate Intake in Active, Healthy Females.

    Science.gov (United States)

    Gregory, Sara; Wood, Richard; Matthews, Tracey; Vanlangen, Deborah; Sawyer, Jason; Headley, Samuel

    2011-01-01

    The present study compared the metabolic responses between a single low-carbohydrate (LC) and low-fat (LF) meal followed by an aerobic exercise bout in females. Subjects included 8 active, premenopausal females. Subjects completed a LC and LF testing session. Respiratory gas exchange (RER) measurements were taken for 20 min fasted, for 55 min postprandial (PP), and during 30 min of exercise. Blood was collected for assessment of glucose (G), insulin (IN), triglycerides (TG), and free fatty acids (FFA) during the final 10 min of each time period. The LF meal provided 396 kcal (78% carbohydrate, 7% fat, and 15% protein). The LC meal provided 392 kcal (15% carbohydrate, 68% fat, and 18% protein). No significant differences existed between test meals for fasting blood measurements. PP IN (μU·mL(-1)) levels were significantly lower following LC compared to LF [10.7 (6.1) vs. 26.0 (21.0)]. Postexercise (PE) FFA (mEq·L(-1)) levels were significantly greater following LC [1.1 (0.3) vs. 0.5 (0.3)]. PE TG (mg·dL(-1)) levels were significantly greater following LC [152.0 (53.1) vs. 114.4 (40.9)]. RER was significantly lower at all time points following LC compared to LF. In moderately active adult females, ingestion of a single LC meal resulted in greater lipid oxidation at rest and during exercise as compared to a single LF meal. Although macronutrient distribution appears to have dictated substrate utilization in the present study, more research is needed regarding the long-term effects of macronutrient redistribution with and without exercise on substrate utilization. Key pointsThe relative carbohydrate content of a single meal has a significant impact on postprandial metabolism and substrate utilization in healthy, active females.A single bout of aerobic exercise performed within an hour of meal ingestion has the potential to modify the postprandial response.Interventions aimed at improving body composition and preventing chronic disease should focus on dietary

  9. Energy substrate utilization during nightly vocal activity in three species of Scinax (Anura/Hylidae).

    Science.gov (United States)

    Carvalho, José Eduardo; Gomes, Fernando Ribeiro; Navas, Carlos Arturo

    2008-05-01

    Anuran amphibians exhibit different patterns of energy substrate utilization that correlate with the intensity of vocal and locomotor activities. Given the remarkable differences among species in breeding and feeding strategies, and the different ways energy is used in the whole animal, the suggested correlations between calling and locomotor behavior and the level of energy substrates in the muscles responsible for such activities are more complex than previously reported. We explored the relationships between calling and locomotor behavior and energy supply to trunk and hindlimb muscles, respectively, within the ecologically diverse tree-frog genus Scinax. Specifically, we measured the relative amount of carbohydrates and lipids in these two groups of muscles, and in the liver of three species of Scinax that differ in vocal and locomotor performance, and compared our results with those of two other species for which comparable data are available. We also compared the contents of lipids and carbohydrates of conspecific males collected at the beginning and after 4 h of calling activity. The stomach content to potential feeding opportunities across species was also assessed in both groups of males. Scinax hiemalis and S. rizibilis exhibit comparatively low and episodic calling during long periods of activity whereas S. crospedospilus calls at higher rates over shorter periods. Male S. hiemalis had highest levels of trunk muscle glycogen followed by those of S. rizilbilis and S. crospedospilus, respectively. There was no correlation between total lipid content in trunk muscle and calling rate among different species, suggesting that other metabolic aspects may be responsible for the energetic support for vocal activity. The levels of lipids and carbohydrates in trunk and hindlimb muscles and liver of males collected at the beginning and 4 h into the calling period were similar across species, so the extent of energetic reserves does not appear to constrain vocal or

  10. SUBSTRATE UTILIZATION IS INFLUENCED BY ACUTE DIETARY CARBOHYDRATE INTAKE IN ACTIVE, HEALTHY FEMALES

    Directory of Open Access Journals (Sweden)

    Sara Gregory

    2011-03-01

    Full Text Available The present study compared the metabolic responses between a single low-carbohydrate (LC and low-fat (LF meal followed by an aerobic exercise bout in females. Subjects included 8 active, premenopausal females. Subjects completed a LC and LF testing session. Respiratory gas exchange (RER measurements were taken for 20 min fasted, for 55 min postprandial (PP, and during 30 min of exercise. Blood was collected for assessment of glucose (G, insulin (IN, triglycerides (TG, and free fatty acids (FFA during the final 10 min of each time period. The LF meal provided 396 kcal (78% carbohydrate, 7% fat, and 15% protein. The LC meal provided 392 kcal (15% carbohydrate, 68% fat, and 18% protein. No significant differences existed between test meals for fasting blood measurements. PP IN (µU·mL-1 levels were significantly lower following LC compared to LF [10.7 (6.1 vs. 26.0 (21.0]. Postexercise (PE FFA (mEq·L-1 levels were significantly greater following LC [1.1 (0.3 vs. 0.5 (0.3]. PE TG (mg·dL-1 levels were significantly greater following LC [152.0 (53.1 vs. 114.4 (40.9]. RER was significantly lower at all time points following LC compared to LF. In moderately active adult females, ingestion of a single LC meal resulted in greater lipid oxidation at rest and during exercise as compared to a single LF meal. Although macronutrient distribution appears to have dictated substrate utilization in the present study, more research is needed regarding the long-term effects of macronutrient redistribution with and without exercise on substrate utilization.

  11. Essentiality of respiratory activity for pentose utilization in thermotolerant yeast Kluyveromyces marxianus DMKU 3-1042.

    Science.gov (United States)

    Lertwattanasakul, Noppon; Suprayogi; Murata, Masayuki; Rodrussamee, Nadchanok; Limtong, Savitree; Kosaka, Tomoyuki; Yamada, Mamoru

    2013-04-01

    By random integrative mutagenesis with a kanMX4 cassette in Kluyveromyces marxianus DMKU 3-1042, we obtained three mutants of COX15, ATP25 and CYC3 encoding a cytochrome oxidase assembly factor (singleton), a transcription factor required for assembly of the Atp9p subunit of mitochondrial ATP synthase and cytochrome c heme lyase, respectively, as mutants lacking growth capability on xylose and/or arabinose. They exhibited incapability of growth on non-fermentable carbon sources, such as acetate or glycerol, and thermosensitiveness. Their biomass formation in glucose medium was reduced, but ethanol yields were increased with a high ethanol level in the medium, compared to those of the parental strain. Experiments with respiratory inhibitors showed that cox15 and cyc3, but not atp25, were able to grow in glucose medium containing antimycin A and that the atp25 mutant was KCN-resistant. Activities of NADH and ubiquinol oxidases in membrane fractions of each mutant became a half of that of the parent and negligible, respectively, and their remaining NADH oxidase activities were found to be resistant to KCN. Absolute absorption spectral analysis revealed that the peak corresponding to a + a 3 was very small in atp25 and negligible in cox15 and cyc3. These findings suggest that the K. marxianus strain possesses an alternative KCN-resistant oxidase that is located between primary dehydrogenases and the ubiquinone pool and that the respiratory activity is essential for utilization of pentoses.

  12. The cost-utility of open prostatectomy compared with active surveillance in early localised prostate cancer

    Science.gov (United States)

    2014-01-01

    Background There is an on-going debate about whether to perform surgery on early stage localised prostate cancer and risk the common long term side effects such as urinary incontinence and erectile dysfunction. Alternatively these patients could be closely monitored and treated only in case of disease progression (active surveillance). The aim of this paper is to develop a decision-analytic model comparing the cost-utility of active surveillance (AS) and radical prostatectomy (PE) for a cohort of 65 year old men with newly diagnosed low risk prostate cancer. Methods A Markov model comparing PE and AS over a lifetime horizon was programmed in TreeAge from a German societal perspective. Comparative disease specific mortality was obtained from the Scandinavian Prostate Cancer Group trial. Direct costs were identified via national treatment guidelines and expert interviews covering in-patient, out-patient, medication, aids and remedies as well as out of pocket payments. Utility values were used as factor weights for age specific quality of life values of the German population. Uncertainty was assessed deterministically and probabilistically. Results With quality adjustment, AS was the dominant strategy compared with initial treatment. In the base case, it was associated with an additional 0.04 quality adjusted life years (7.60 QALYs vs. 7.56 QALYs) and a cost reduction of €6,883 per patient (2011 prices). Considering only life-years gained, PE was more effective with an incremental cost-effectiveness ratio of €96,420/life year gained. Sensitivity analysis showed that the probability of developing metastases under AS and utility weights under AS are a major sources of uncertainty. A Monte Carlo simulation revealed that AS was more likely to be cost-effective even under very high willingness to pay thresholds. Conclusion AS is likely to be a cost-saving treatment strategy for some patients with early stage localised prostate cancer. However, cost-effectiveness is

  13. Utility of in vitro test methods to assess the activity of xenoestrogens in fish.

    Science.gov (United States)

    Marlatt, Vicki L; Hewitt, L Mark; Van Der Kraak, Glen

    2006-12-01

    The results of the present study have demonstrated the utility of an estrogen receptor (ER) competitive ligand-binding assay, a hepatocyte vitellogenin (VTG) induction bioassay, and an ER reporter gene bioassay in characterizing the activity of model estrogen agonists (17beta-estradiol [E2], ethynylestradiol, and nonylphenol) and antagonists (tamoxifen and ZM 189154) in rainbow trout (Oncorhynchus mykiss). The in vitro results were validated against in vivo trout waterborne exposures to E2 and tamoxifen. The results showed that all three in vitro assays were capable of detecting the hormonal activities of the selected model compounds in a dose-dependent manner, with the exception of nonylphenol in the ER reporter gene bioassay. However, the relative potency rankings of the model compounds were not consistent between these assays, which suggests that the relative potencies obtained within assays may have limited predictive value between assays. Discrepancies in potencies most likely can be attributed to the different levels of cellular organization in each assay. In addition to model compounds, we also evaluated the responses of the ER-binding assay and the hepatocyte VTG induction bioassay to complex mixtures associated with endocrine effects in fish, specifically extracts of pulp mill effluent. Of the 14 pulp mill effluent extracts tested, only six showed activity in both assays, whereas the remaining eight samples showed activity in only one of the two assays. The hepatocyte VTG induction bioassay consistently showed that the pulp mill effluent extracts were antiestrogenic, which to our knowledge has not been reported in previous studies. Collectively, these results suggest that a combination of in vitro assays that depend on differing endpoints is required to identify potential xenoestrogens and to characterize their modes of action.

  14. COPD symptom burden: impact on health care resource utilization, and work and activity impairment

    Directory of Open Access Journals (Sweden)

    Ding B

    2017-02-01

    Full Text Available Bo Ding,1 Mark Small,2 Gina Bergström,3 Ulf Holmgren3 1Medical Evidence and Observational Research, AstraZeneca Gothenburg, Mölndal, Sweden; 2Real World Research (Respiratory, Adelphi Real World, Bollington, UK; 3Global Payer Evidence and Pricing, AstraZeneca Gothenburg, Mölndal, Sweden Background: Chronic obstructive pulmonary disease (COPD can greatly impact the quality of life by limiting patients’ activities. However, data on impact of symptomatic burden on the health care resource utilization (HCRU and employment in COPD are lacking. We examined the association between COPD Assessment Test (CAT score and direct/indirect costs associated with HCRU and work productivity.Methods: Data from >2,100 patients with COPD consulting for routine care were derived from respiratory disease-specific programs in Europe, the USA and China. Questionnaires, including CAT and Work Productivity and Activity Impairment (WPAI, were used to collect the past and current disease status data and HCRU characteristics from physicians (general practitioners/specialists and patients. A regression approach was used to quantify the association of CAT with HCRU and WPAI variables. CAT score was modeled as a continuous independent variable (range: 0–40.Results: Ninety percent of patients with COPD had a CAT score ≥10. Short-acting therapy and maintenance bronchodilator monotherapy, respectively, were currently prescribed to patients with CAT scores of 10–19 (5.8% and 27.6%, 20–29 (5.1% and 13.1% and 30–40 (2.8% and 6.6%. Prescribing of maintenance bronchodilator dual therapy was low across the CAT score groups (0–9, 7.8%; 10–19, 6.4%; 20–29, 5.9%; 30–40, 4.4%, whereas maintenance triple combination therapy was prescribed more commonly in patients with higher CAT scores (0–9, 16.1%; 10–19, 23.2%; 20–29, 25.9%; 30–40, 35.5%. Increasing CAT scores were significantly associated with a higher frequency of primary care physician visits (P<0

  15. Wood utilization is dependent on catalase activities in the filamentous fungus Podospora anserina.

    Science.gov (United States)

    Bourdais, Anne; Bidard, Frederique; Zickler, Denise; Berteaux-Lecellier, Veronique; Silar, Philippe; Espagne, Eric

    2012-01-01

    Catalases are enzymes that play critical roles in protecting cells against the toxic effects of hydrogen peroxide. They are implicated in various physiological and pathological conditions but some of their functions remain unclear. In order to decipher the role(s) of catalases during the life cycle of Podospora anserina, we analyzed the role of the four monofunctional catalases and one bifunctional catalase-peroxidase genes present in its genome. The five genes were deleted and the phenotypes of each single and all multiple mutants were investigated. Intriguingly, although the genes are differently expressed during the life cycle, catalase activity is dispensable during both vegetative growth and sexual reproduction in laboratory conditions. Catalases are also not essential for cellulose or fatty acid assimilation. In contrast, they are strictly required for efficient utilization of more complex biomass like wood shavings by allowing growth in the presence of lignin. The secreted CATB and cytosolic CAT2 are the major catalases implicated in peroxide resistance, while CAT2 is the major player during complex biomass assimilation. Our results suggest that P. anserina produces external H(2)O(2) to assimilate complex biomass and that catalases are necessary to protect the cells during this process. In addition, the phenotypes of strains lacking only one catalase gene suggest that a decrease of catalase activity improves the capacity of the fungus to degrade complex biomass.

  16. Wood utilization is dependent on catalase activities in the filamentous fungus Podospora anserina.

    Directory of Open Access Journals (Sweden)

    Anne Bourdais

    Full Text Available Catalases are enzymes that play critical roles in protecting cells against the toxic effects of hydrogen peroxide. They are implicated in various physiological and pathological conditions but some of their functions remain unclear. In order to decipher the role(s of catalases during the life cycle of Podospora anserina, we analyzed the role of the four monofunctional catalases and one bifunctional catalase-peroxidase genes present in its genome. The five genes were deleted and the phenotypes of each single and all multiple mutants were investigated. Intriguingly, although the genes are differently expressed during the life cycle, catalase activity is dispensable during both vegetative growth and sexual reproduction in laboratory conditions. Catalases are also not essential for cellulose or fatty acid assimilation. In contrast, they are strictly required for efficient utilization of more complex biomass like wood shavings by allowing growth in the presence of lignin. The secreted CATB and cytosolic CAT2 are the major catalases implicated in peroxide resistance, while CAT2 is the major player during complex biomass assimilation. Our results suggest that P. anserina produces external H(2O(2 to assimilate complex biomass and that catalases are necessary to protect the cells during this process. In addition, the phenotypes of strains lacking only one catalase gene suggest that a decrease of catalase activity improves the capacity of the fungus to degrade complex biomass.

  17. Two propanediol utilization-like proteins of Moorella thermoacetica with phosphotransacetylase activity.

    Science.gov (United States)

    Breitkopf, Ronja; Uhlig, Ronny; Drenckhan, Tina; Fischer, Ralf-Jörg

    2016-09-01

    Moorella thermoacetica is one of the model acetogenic bacteria for the resolution of the Wood-Ljungdahl (acetyl-CoA) pathway in which CO2 is autotrophically assimilated yielding acetyl-CoA as central intermediate. Its further conversion into acetate relies on subsequent phosphotransacetylase (PTA) and acetate kinase reactions. However, the genome of M. thermoacetica contains no pta homologous gene. It has been speculated that the moth_0864 and moth_1181 gene products sharing similarities with an evolutionarily distinct phosphotransacylase involved in 1,2-propanediol utilization (PDUL) of Salmonella enterica act as PTAs in M. thermoacetica. Here, we demonstrate specific PTA activities with acetyl-CoA as substrate of 9.05 and 2.03 U/mg for the recombinant enzymes PDUL1 (Moth_1181) and PDUL2 (Moth_0864), respectively. Both showed maximal activity at 65 °C and pH 7.6. Native proteins (90 kDa) are homotetramers composed of four subunits with apparent molecular masses of about 23 kDa. Thus, one or both PDULs of M. thermoacetica might act as PTAs in vivo catalyzing the penultimate step of the Wood-Ljungdahl pathway toward the formation of acetate. In silico analysis underlined that up to now beside of M. thermoacetica, only Sporomusa ovata contains only PDUL like class(III)-PTAs but no other phosphotransacetylases or phosphotransbutyrylases (PTBs).

  18. Prioritization of polysaccharide utilization and control of regulator activation in Bacteroides thetaiotaomicron.

    Science.gov (United States)

    Schwalm, Nathan D; Townsend, Guy E; Groisman, Eduardo A

    2017-04-01

    Bacteroides thetaiotaomicron is a human gut symbiotic bacterium that utilizes a myriad of host dietary and mucosal polysaccharides. The proteins responsible for the uptake and breakdown of many of these polysaccharides are transcriptionally regulated by hybrid two-component systems (HTCSs). These systems consist of a single polypeptide harboring the domains of sensor kinases and response regulators, and thus, are thought to autophosphorylate in response to specific signals. We now report that the HTCS BT0366 is phosphorylated in vivo when B. thetaiotaomicron experiences the BT0366 inducer arabinan but not when grown in the presence of glucose. BT0366 phosphorylation and transcription of BT0366-activated genes requires the conserved predicted sites of phosphorylation in BT0366. When chondroitin sulfate is added to arabinan-containing cultures, BT0366 phosphorylation and transcription of BT0366-activated genes are inhibited and the bacterium exhibits diauxic growth. Whereas 20 additional combinations of polysaccharides also give rise to diauxic growth, other combinations result in synergistic or unaltered growth relative to bacteria experiencing a single polysaccharide. The different strategies employed by B. thetaiotaomicron when faced with multiple polysaccharides may aid its competitiveness in the mammalian gut. © 2016 John Wiley & Sons Ltd.

  19. Geospatial Relationships between Awareness and Utilization of Community Exercise Resources and Physical Activity Levels in Older Adults

    Directory of Open Access Journals (Sweden)

    Christopher J. Dondzila

    2014-01-01

    Full Text Available Introduction. It is unclear if community-based fitness resources (CBFR translate to heightened activity levels within neighboring areas. The purpose of this study was to determine whether awareness and utilization of fitness resources and physical activity differed depending on residential distance from CBFR. Methods. Four hundred and seventeen older adults (72.9±7.7 years were randomly recruited from three spatial tiers (≤1.6, >1.6 to ≤3.2, and >3.2 to 8.0 km surrounding seven senior centers, which housed CBFR. Participants completed questionnaires on health history, CBFR, and physical activity, gathering data on CBFR awareness, utilization, and barriers, overall levels, and predictors to engagement in moderate to vigorous physical activity (MVPA. Results. Across spatial tiers, there were no differences in positive awareness rates of CBFR or CBFR utilization. Engagement in MVPA differed across spatial tiers P3.2 to 8.0 km radius having the highest mean energy expenditure. Across all sites, age and income level P<0.05 were significant predictors of low and high amounts of MVPA, respectively, and current health status and lack of interest represented barriers to CBFR utilization P<0.05. Conclusion. Closer proximity to CBFR did not impact awareness or utilization rates and had an inverse relationship with physical activity.

  20. Carbohydrate-active enzymes from pigmented Bacilli: a genomic approach to assess carbohydrate utilization and degradation

    Directory of Open Access Journals (Sweden)

    Henrissat Bernard

    2011-09-01

    Full Text Available Abstract Background Spore-forming Bacilli are Gram-positive bacteria commonly found in a variety of natural habitats, including soil, water and the gastro-intestinal (GI-tract of animals. Isolates of various Bacillus species produce pigments, mostly carotenoids, with a putative protective role against UV irradiation and oxygen-reactive forms. Results We report the annotation of carbohydrate active enzymes (CAZymes of two pigmented Bacilli isolated from the human GI-tract and belonging to the Bacillus indicus and B. firmus species. A high number of glycoside hydrolases (GHs and carbohydrate binding modules (CBMs were found in both isolates. A detailed analysis of CAZyme families, was performed and supported by growth data. Carbohydrates able to support growth as the sole carbon source negatively effected carotenoid formation in rich medium, suggesting that a catabolite repression-like mechanism controls carotenoid biosynthesis in both Bacilli. Experimental results on biofilm formation confirmed genomic data on the potentials of B. indicus HU36 to produce a levan-based biofilm, while mucin-binding and -degradation experiments supported genomic data suggesting the ability of both Bacilli to degrade mammalian glycans. Conclusions CAZy analyses of the genomes of the two pigmented Bacilli, compared to other Bacillus species and validated by experimental data on carbohydrate utilization, biofilm formation and mucin degradation, suggests that the two pigmented Bacilli are adapted to the intestinal environment and are suited to grow in and colonize the human gut.

  1. Carbohydrate-active enzymes from pigmented Bacilli: a genomic approach to assess carbohydrate utilization and degradation

    Science.gov (United States)

    2011-01-01

    Background Spore-forming Bacilli are Gram-positive bacteria commonly found in a variety of natural habitats, including soil, water and the gastro-intestinal (GI)-tract of animals. Isolates of various Bacillus species produce pigments, mostly carotenoids, with a putative protective role against UV irradiation and oxygen-reactive forms. Results We report the annotation of carbohydrate active enzymes (CAZymes) of two pigmented Bacilli isolated from the human GI-tract and belonging to the Bacillus indicus and B. firmus species. A high number of glycoside hydrolases (GHs) and carbohydrate binding modules (CBMs) were found in both isolates. A detailed analysis of CAZyme families, was performed and supported by growth data. Carbohydrates able to support growth as the sole carbon source negatively effected carotenoid formation in rich medium, suggesting that a catabolite repression-like mechanism controls carotenoid biosynthesis in both Bacilli. Experimental results on biofilm formation confirmed genomic data on the potentials of B. indicus HU36 to produce a levan-based biofilm, while mucin-binding and -degradation experiments supported genomic data suggesting the ability of both Bacilli to degrade mammalian glycans. Conclusions CAZy analyses of the genomes of the two pigmented Bacilli, compared to other Bacillus species and validated by experimental data on carbohydrate utilization, biofilm formation and mucin degradation, suggests that the two pigmented Bacilli are adapted to the intestinal environment and are suited to grow in and colonize the human gut. PMID:21892951

  2. Carbohydrate-active enzymes from pigmented Bacilli: a genomic approach to assess carbohydrate utilization and degradation.

    Science.gov (United States)

    Manzo, Nicola; D'Apuzzo, Enrica; Coutinho, Pedro M; Cutting, Simon M; Henrissat, Bernard; Ricca, Ezio

    2011-09-05

    Spore-forming Bacilli are gram-positive bacteria commonly found in a variety of natural habitats, including soil, water and the gastro-intestinal (GI)-tract of animals. Isolates of various Bacillus species produce pigments, mostly carotenoids, with a putative protective role against UV irradiation and oxygen-reactive forms. We report the annotation of carbohydrate active enzymes (CAZymes) of two pigmented Bacilli isolated from the human GI-tract and belonging to the Bacillus indicus and B. firmus species. A high number of glycoside hydrolases (GHs) and carbohydrate binding modules (CBMs) were found in both isolates. A detailed analysis of CAZyme families, was performed and supported by growth data. Carbohydrates able to support growth as the sole carbon source negatively effected carotenoid formation in rich medium, suggesting that a catabolite repression-like mechanism controls carotenoid biosynthesis in both Bacilli. Experimental results on biofilm formation confirmed genomic data on the potentials of B. indicus HU36 to produce a levan-based biofilm, while mucin-binding and -degradation experiments supported genomic data suggesting the ability of both Bacilli to degrade mammalian glycans. CAZy analyses of the genomes of the two pigmented Bacilli, compared to other Bacillus species and validated by experimental data on carbohydrate utilization, biofilm formation and mucin degradation, suggests that the two pigmented Bacilli are adapted to the intestinal environment and are suited to grow in and colonize the human gut.

  3. A wireless recording system that utilizes Bluetooth technology to transmit neural activity in freely moving animals.

    Science.gov (United States)

    Hampson, Robert E; Collins, Vernell; Deadwyler, Sam A

    2009-09-15

    A new wireless transceiver is described for recording individual neuron firing from behaving rats utilizing Bluetooth transmission technology and a processor onboard for discrimination of neuronal waveforms and associated time stamps. This universal brain activity transmitter (UBAT) is attached to rodents via a backpack and amplifier headstage and can transmit 16 channels of captured neuronal firing data via a Bluetooth transceiver chip over very large and unconstrained distances. The onboard microprocessor of the UBAT allows flexible online control over waveform isolation criteria via transceiver instruction and the two-way communication capacity allows for closed-loop applications between neural events and behavioral or physiological processes which can be modified by transceiver instructions. A detailed description of the multiplexer processing of channel data as well as examples of neuronal recordings in different behavioral testing contexts is provided to demonstrate the capacity for robust transmission within almost any laboratory environment. A major advantage of the UBAT is the long transmission range and lack of object-based line of sight interference afforded by Bluetooth technology, allowing flexible recording capabilities within multiple experimental paradigms without interruption. Continuous recordings over very large distance separations from the monitor station are demonstrated providing experimenters with recording advantages not previously available with other telemetry devices.

  4. Features and amenities of school playgrounds: A direct observation study of utilization and physical activity levels outside of school time

    Directory of Open Access Journals (Sweden)

    Swayampakala Kamala

    2011-04-01

    Full Text Available Abstract Background A significant amount of research has examined whether park or playground availability is associated with physical activity. However, little research has examined whether specific features or amenities of parks or playgrounds, such as the number of unique types of playground equipment or the safety of the equipment is associated with utilization of the facility or physical activity levels while at the facility. There are no studies that use direct observation and a detailed park assessment to examine these associations. Methods Twenty urban schoolyards in the Midwest, ten of which were renovated, were included in this study. Using a detailed environmental assessment tool (i.e., Environmental Assessment of Public Recreation Spaces, information on a variety of playground attributes was collected. Using direct observation (i.e., System for Observing Play and Leisure Activity in Youth, the number of adults, girls and boys attending each schoolyard and their physical activity levels were recorded. Each schoolyard was observed ten times for 90 minutes each time outside of school hours. Clustered multivariable negative binomial regressions and linear regressions were completed to examine the association between playground attributes and utilization of the schoolyard and the proportion active on the playground, respectively. Effect modification by renovation status was also examined. Results At renovated schoolyards, the total number of play features was significantly associated with greater utilization in adults and girls; overall cleanliness was significantly associated with less utilization in girls and boys; and coverage/shade for resting features was significantly associated with greater utilization in adults and boys. At unrenovated schoolyards, overall safety was significantly associated with greater utilization in boys. No playground attribute was associated with the proportion active on the playground after adjusting for all

  5. Evaluation for status and utilization of neutron activation analysis facility of HANARO research reactor (1996-2003)

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Yong Sam; Moon, Jong Hwa; Chung, Young Ju; Kim, Sun Ha; Baek, Sung Ryel; Cho, Hyun Je; Park, Kwang Won; Kang, Sang Hun; Lim, Jong Myoung; Kim, Young Jin

    2004-05-01

    This report is written for the evaluation of the utilization and the status of Neutron Activation Analysis (NAA) facility of HANARO research reactor (1996-2003) which is accomplished by NAA user supporting system ; (i) the results by the number of sample is classified the research and development and analytical service, each item which is divided into the type of supporting (component analysis, nuclide analysis, neutron irradiation) and the field of utilization (environment, human health, industrial materials, standard materials, social and culture and others) are summarized with relevant contents in detail, (ii) The trends of the utilization is evaluated with a technology, a field, an organization of utilization, (iii) the results of training and education for students and users, the survey of user's demand, the investigation of self-satisfaction for NAA user supporting system.

  6. Brain Network Activation Analysis Utilizing Spatiotemporal Features for Event Related Potentials Classification

    Directory of Open Access Journals (Sweden)

    Yaki Stern

    2016-12-01

    Full Text Available The purpose of this study was to introduce an improved tool for automated classification of event-related potentials (ERPs using spatiotemporally parcellated events incorporated into a functional brain network activation (BNA analysis. The auditory oddball ERP paradigm was selected to demonstrate and evaluate the improved tool. Methods: The ERPs of each subject were decomposed into major dynamic spatiotemporal events. Then, a set of spatiotemporal events representing the group was generated by aligning and clustering the spatiotemporal events of all individual subjects. The temporal relationship between the common group events generated a network, which is the spatiotemporal reference BNA model. Scores were derived by comparing each subject’s spatiotemporal events to the reference BNA model and were then entered into a support vector machine classifier to classify subjects into relevant subgroups. The reliability of the BNA scores (test-retest repeatability using intraclass correlation and their utility as a classification tool were examined in the context of Target-Novel classification. Results: BNA intraclass correlation values of repeatability ranged between 0.51 and 0.82 for the known ERP components N100, P200 and P300. Classification accuracy was high when the trained data were validated on the same subjects for different visits (AUCs 0.93 and 0.95. The classification accuracy remained high for a test group recorded at a different clinical center with a different recording system (AUCs 0.81, 0.85 for 2 visits. Conclusion: The improved spatiotemporal BNA analysis demonstrates high classification accuracy. The BNA analysis method holds promise as a tool for diagnosis, follow-up and drug development associated with different neurological conditions.

  7. Survey of state regulatory activities on least cost planning for gas utilities

    Energy Technology Data Exchange (ETDEWEB)

    Goldman, C.A. (Lawrence Berkeley Lab., CA (United States) National Association of Regulatory Utility Commissioners, Washington, DC (United States)); Hopkins, M.E. (Fleming Group, Washington, DC (United States))

    1991-04-01

    Integrated resource planning involves the creation of a process in which supply-side and demand-side options are integrated to create a resource mix that reliably satisfies customers' short-term and long-term energy service needs at the lowest cost. Incorporating the concept of meeting customer energy service needs entails a recognition that customers' costs must be considered along with the utility's costs in the economic analysis of energy options. As applied to gas utilities, an integrated resource plan seeks to balance cost and reliability, and should not be interpreted simply as the search for lowest commodity costs. All state commissions were surveyed to assess the current status of gas planning and demand-side management and to identify significant regulatory issues faced by commissions during the next several years. The survey was to determine the extent to which they have undertaken least-cost planning for gas utilities. The survey included the following topics: (1) status of state PUC least-cost planning regulations and practices for gas utilities; (2) type and scope ofnatural gas DSM programs in effect, includeing fuel substitution; (3) economic tests and analysis methods used to evaluate DSM programs; (4) relationship between prudence reviews of gas utility purchasing practices and integrated resource planning; and (5) key regulatory issues facing gas utilities during the next five years. 34 refs., 6 figs., 10 tabs.

  8. Association between obesity, quality of life, physical activity and health service utilization in primary care patients with osteoarthritis.

    NARCIS (Netherlands)

    Rosemann, T.J.; Grol, R.P.T.M.; Herman, K.; Wensing, M.J.P.; Szecsenyi, J.

    2008-01-01

    ABSTRACT: OBJECTIVE: To assess the association of obesity with quality of life, health service utilization and physical activity in a large sample of primary care patients with osteoarthritis (OA). METHODS: Data were retrieved from the PraxArt project, representing a cohort of 1021 primary care pati

  9. Electromyographical characteristics and muscle utilization in hemiplegic patients during sit-to-stand activity: an observational study.

    Science.gov (United States)

    Lu, Rong R; Li, Fang; Zhu, Bing

    2016-04-01

    Sit-to-stand is an important process in daily activity, and stroke patients have difficulty completing this task due to many reasons. To investigate the characteristic of muscle utilization of lower limb muscles between healthy participants and hemiplegic patients during sit-to-stand activity. This is an observational study. Inpatients at a rehabilitation hospital. Thirty-two stroke patients and 36 healthy participants. The participants were evaluated on sit-to-stand movement. Muscle strength was assessed by measuring maximal voluntary contraction (MVC) bilaterally in quadriceps, hamstrings, tibialis anterior and gastrocnemius. Amplitude (average and maximal) and area under the curve (AUC) of quadriceps, hamstring, tibialis anterior, and gastrocnemius of both sides were recorded during this activity. The average and maximal amplitudes of paretic muscles were significantly less than non-paretic muscles and healthy controls (Psit-to-stand activity in hemiplegic patients. During sit-to-stand, stroke patients' muscle utilization of both sides increased and MUR of the paretic side is similar to the non-paretic side. Muscle utilization ratio might help to understand how patients fulfill the sit-to-stand task. Using this information might improve our training strategy. Through customized training, paretic patients could fulfill the task with less muscle utilization.

  10. Mindfulness, health symptoms and healthcare utilization: Active facets and possible affective mediators.

    Science.gov (United States)

    Consedine, Nathan S; Butler, Haley F

    2014-01-01

    Prior work has linked mindfulness with superior physical and psychological health outcomes. However, studies to date have infrequently tested the unique contributions of individual mindfulness facets, inadequately tested links between facets and healthcare utilization, and have not tested whether depression or anxiety may influence these links. In the current report, 40 young, middle aged and older adults (N = 121) completed measures of dispositional mindfulness, health, healthcare utilization and depression/anxiety. As expected, global trait mindfulness did not predict outcomes while individual mindfulness facets predicted both objective and subjective health as well as healthcare utilization. Across models, observe scores - the tendency to attend to thoughts, sensations and feelings - predicted poorer, and non-reactivity scores better, outcomes even when controlling for demographic and health confounds. Depressed and anxious emotion reduced some but not all mindfulness-health links. Results are discussed in terms of the mechanisms by which greater mindfulness may facilitate better health and health behaviour.

  11. Discussion of impact of relics activation on protection and utilization approaches-take the old summer palace as an example

    Science.gov (United States)

    Xiaoqi, J.

    2015-08-01

    As the popularization of cultural relics and the rapid development of cultural tourism industry, a large number of cultural relic tourism resources goes into public eyes. Activation of relics has became an important way for tourist to contact and understand culture relics. The way of how to properly interpret the historical sense and cultural uniqueness to the masses of tourists in order to achieve social service functions of relic resources has always been research focal point of site protection and utilization, so nowadays it has important significance to protection and utilization of heritage resources in our country. From the point of activation of relics and based on the analysis of resource characteristic, the paper in depth discuss ways of activation of relics of the Old Summer Palace, in order to provide reference for sustainable development of sites tourism in China.

  12. Alcohol Services for Mexican Americans: A Review of Utilization Patterns, Treatment Considerations and Prevention Activities.

    Science.gov (United States)

    Gilbert, M. Jean; Cervantes, Richard C.

    1986-01-01

    Synthesizes available literature that addresses: (1) utilization patterns of alcohol-related services by Mexican Americans; (2) existing therapeutic approaches which take into account cultural factors; and (3) existing approaches to alcohol abuse education and prevention for this population. Discusses research needs and the need for…

  13. CeIR-mediated activation of the cellobiose-utilization gene cluster in Streptococcus pneumoniae

    NARCIS (Netherlands)

    Shafeeq, Sulman; Kloosterman, Tomas G.; Kuipers, Oscar P.; Mitchell, T.J.

    2011-01-01

    The human pathogen Streptococcus pneumoniae harbours many genes encoding phosphotransferase systems and sugar ABC (ATP-binding cassette) transporters, including systems for the utilization of the beta-glucoside sugar cellobiose. In this study, we show that the transcriptional regulator CeIR, which h

  14. Recent progress in understanding activity cliffs and their utility in medicinal chemistry.

    Science.gov (United States)

    Stumpfe, Dagmar; Hu, Ye; Dimova, Dilyana; Bajorath, Jürgen

    2014-01-09

    The activity cliff concept is of high relevance for medicinal chemistry. Recent studies are discussed that have further refined our understanding of activity cliffs and suggested different ways of exploiting activity cliff information. These include alternative approaches to define and classify activity cliffs in two and three dimensions, data mining investigations to systematically detect all possible activity cliffs, the introduction of computational methods to predict activity cliffs, and studies designed to explore activity cliff progression in medicinal chemistry. The discussion of these studies is complemented with new findings revealing the frequency of activity cliff formation when different molecular representations are used and the distribution of activity cliffs across different targets. Taken together, the results have a number of implications for the practice of medicinal chemistry.

  15. A comparison of costs associated with utility management options for dry active waste

    Energy Technology Data Exchange (ETDEWEB)

    Hornibrook, C. [EPRI, Palo Alto, CA (United States)

    1995-12-31

    The economics of low level waste management is receiving more attention today than ever before. This is due to four factors: (1) the increases in the cost of processing of these wastes; (2) increases in the cost of disposal; (3) the addition of storage costs for those without access to disposal; and (4) the increasing competitive nature of the electric generation industry. These pressures are forcing the industry to update it`s evaluation of the mix of processing that will afford it the best long term economics and minimize it`s risks for unforeseen costs. Whether disposal is available or not, all utilities face the same challenge of minimizing the costs associated with the management of these wastes. There are a number of variables that will impact how a utility manages their wastes but the problem is the uncertainty of what will actually happen, i.e., will disposal be available, when and at what cost. Using the EPRI-developed WASTECOST: DAW code, this paper explores a variety of LLW management options available to utilities. Along with providing the costs and benefits, other technical considerations which play an important part in the management of these wastes are also addressed.

  16. THE GRONINGEN ACTIVITY RESTRICTION SCALE FOR MEASURING DISABILITY - ITS UTILITY IN INTERNATIONAL COMPARISONS

    NARCIS (Netherlands)

    SUURMEIJER, TPBM; DOEGLAS, DM; MOUM, T; BRIANCON, S; KROL, B; SANDERMAN, R; GUILLEMIN, F; BJELLE, A; VAMDENHEUVEL, WJA

    1994-01-01

    Objectives. The Groningen Activity Restriction Scale (GARS) is a non-disease-specific instrument to measure disability in activities of daily living (ADL) and instrumental activities of daily living (IADL). It was developed in studies of Dutch samples consisting of elderly or chronically ill people.

  17. Utilization of Human Urine as Fertilizer with Magnesium Oxide (MgO, Zeolite and Activated Carbon as Absorbent

    Directory of Open Access Journals (Sweden)

    Hijrah Purnama Putra

    2014-01-01

    Full Text Available Urine is residual fluid excreted by kidneys through urinary tract to outside of the human body, to maintain homeostasis of fluid in the body. Normally urine still contains high amount of nitrogen, which is 87%, phosphor 50%, potassium 54% and low bacterial content. With these contents urine potentially becomes organic fertilizer rich with nitrogen, phosphor and potassium contents and is beneficial to plants. However, until today the utilization or urine in Indonesia is very low. The urine produced is dispose with feces in toilets. This study aimed to utilize urine as solid organic fertilizer using magnesium oxide (MgO, zeolite, and actived carbon as absorbents of ammonium and phosphor. The study started with collecting urine, time variations of urine storage were 24; 48 and 72 hours, and urine was mixed with water as an assumption that urine mixes with water when flushed in urinals. The result showed effectiveness of optimum urine absorption in urine stored for 48 hours by adding 8 gram MgO, producing ammonium and phosphor contents 56.100 ppm and 3.610 ppm, respectively. From environmental perspective, utilization of urine as organic fertilizer was applicable because it satisfied the ecological principle of sanitation to prevent soil pollution, ground and surface water pollution and its utilization as agricultural resources.

  18. Preparation of activated carbons from coffee husks utilizing FeCl3 and ZnCl2 as activating agents.

    Science.gov (United States)

    Oliveira, Luiz C A; Pereira, Elaine; Guimaraes, Iara R; Vallone, Andrea; Pereira, Márcio; Mesquita, João P; Sapag, Karim

    2009-06-15

    Ferric chloride was used as a new activating agent, to obtain activated carbons (AC) from agro industrial waste (coffee husks). This material was compared with two samples from the same raw material: one of them activated by using the classical activating agent, zinc chloride, and the other, activated with a mixture of the two mentioned activating agents in the same mass proportion. The carbonaceous materials obtained after the activation process showed high specific surface areas (BET), with values higher than 900 m(2)g(-1). It is interesting to observe that the activation with FeCl(3) produces smaller pores compared to the activation with ZnCl(2). An important fact to emphasize in the use of FeCl(3) as activating agent is the activation temperature at 280 degrees C, which is clearly below to the temperature commonly employed for chemical or physical activation, as described in the bibliography. All the studied materials showed different behaviors in the adsorption of methylene blue dye and phenol from aqueous solutions.

  19. The Construction of Metal-Organic Framework with Active Backbones by the Utilization of Reticular Chemistry

    Science.gov (United States)

    Choi, Eunwoo

    With the principles of reticular chemistry, metal-organic frameworks with ultra-high porosity, chiral-recognition unit as a chiral stationary phase, metalloporhyrins for enhanced hydrogen adsorption and an intrinsic conductivity to form porous conductors, have been prepared. This dissertation presents how the principles of reticular chemistry were utilized to achieve in the preparations of metal-organic frameworks with a large surface area and active backbones. Through the simple isoreticular (having the same framework topology) expansion from MOF-177 composed with 1,3,5-tris(4'-carboxyphenyl-)benzene (BTB3-) as the strut; MOF-200 was prepared with 4,4',4"-(benzene-1,3,5-triyl-tris(benzene-4,1-diy1))tribenzoic acid an extension from BTB3- by a phenylene unit to yield one of the most porous MOFs with a Langmuir surface area of 10,400 m2. and the lowest density of 0.22 cm3.g-1. A successful thermal polymerization reaction at 325 °C inside of the pores of highly porous MOF, MOF-177, was performed and verified the integrity of the MOF structure even after the thermal reaction. 1,4-Diphenylbutadiyne that is known to polymerize upon heating to form a conjugated backbone was impregnated via solution-diffusion into MOF-177 and then subsequently polymerized by heat to form polymer impregnated MOF-177. Characterization was carried out using powder X-ray diffraction and volumetric sorption analyzer. MOF-1020 with a linear quaterphenyl dicarboxylate-based strut was designed to contain a chiral bisbinaphthyl crown-ether moiety for alkyl ammonium resolution was precisely placed into a Zn4O(CO2)6-based cubic MOF structure. Unfortunately, the chiral resolution was not achieved due to the sensitivity and the pore environment of MOF-1020. However, an interesting phenomenon was observed, where the loss of crystallinity occurs upon solvent removal while the crystallites remain shiny and crystalline, but it readily is restored upon re-solvation of the crystallites. This rare

  20. Utilizing Selected Di- and Trinucleotides of siRNA to Predict RNAi Activity

    Directory of Open Access Journals (Sweden)

    Ye Han

    2017-01-01

    Full Text Available Small interfering RNAs (siRNAs induce posttranscriptional gene silencing in various organisms. siRNAs targeted to different positions of the same gene show different effectiveness; hence, predicting siRNA activity is a crucial step. In this paper, we developed and evaluated a powerful tool named “siRNApred” with a new mixed feature set to predict siRNA activity. To improve the prediction accuracy, we proposed 2-3NTs as our new features. A Random Forest siRNA activity prediction model was constructed using the feature set selected by our proposed Binary Search Feature Selection (BSFS algorithm. Experimental data demonstrated that the binding site of the Argonaute protein correlates with siRNA activity. “siRNApred” is effective for selecting active siRNAs, and the prediction results demonstrate that our method can outperform other current siRNA activity prediction methods in terms of prediction accuracy.

  1. COMPARISON OF LIPOLYTIC ACTIVITY OF Sporothrix schenckii STRAINS UTILIZING OLIVE OIL-RHODAMINE B AND TWEEN 80

    Directory of Open Access Journals (Sweden)

    Mariana Carissimi

    2007-12-01

    Full Text Available The aim of this work was to identify the lipase activity of Sporothrix schenckii strains using Rhodamine B as an indicator of triglyceride hydrolysis (triolein from olive oil and to compare these results with the use of Tween 80 as substrate. Free fatty acids released from lipase activity were detected on agar plate complexed with Rhodamine B, when exposed to UVA light, through orange fluorescence and by precipitation haloes on Tween 80 agar. There were differences in lipolytic activity among strains and between the media utilized. The highest lipase activity (orange fluorescence was observed on the biomass of 10 strains, with no fluorescent haloes around the colonies, whereas only six strains showed large precipitation haloes. These plate assays are suitable for the detection of lipase-producing strains of S. schenckii in the yeast phase, but it is still unknown whether different enzymes act upon the substrates or whether there are variations of the same enzyme with different specificities.

  2. COMPARISON OF LIPOLYTIC ACTIVITY OF Sporothrix schenckii STRAINS UTILIZING OLIVE OIL-RHODAMINE B AND TWEEN 80

    Directory of Open Access Journals (Sweden)

    Mariana Carissimi

    2007-12-01

    Full Text Available The aim of this work was to identify the lipase activity of Sporothrix schenckii strains using Rhodamine B as an indicator oftriglyceride hydrolysis (triolein from olive oil and to compare these results with the use of Tween 80 as substrate. Free fatty acidsreleased from lipase activity were detected on agar plate complexed with Rhodamine B, when exposed to UVA light, through orangefluorescence and by precipitation haloes on Tween 80 agar. There were differences in lipolytic activity among strains and between themedia utilized. The highest lipase activity (orange fluorescence was observed on the biomass of 10 strains, with no fluorescent haloesaround the colonies, whereas only six strains showed large precipitation haloes. These plate assays are suitable for the detection oflipase-producing strains of S. schenckii in the yeast phase, but it is still unknown whether different enzymes act upon the substrates orwhether there are variations of the same enzyme with different specificities.

  3. Estimation of Viable Biomass In Wastewater And Activated Sludge By Determination of ATP, Oxygen Utilization Rate And FDA Hydrolysis

    DEFF Research Database (Denmark)

    Jørgensen, Poul-Erik; Eriksen, T.; Jensen, B.K.

    1992-01-01

    by inoculating a nutrient medium with either wastewater or activated sludge. Biomass was then determined directly by measurement of dry weight of growth culture (dw), and compared to data obtained by using the previously mentioned methods. In the exponential growth phase, ATP content showed the best correlation......ATP content, oxygen utilization rate (OUR) and fluorescein diacetate (FDA) hydrolysis were tested for the ability to express the amount of viable biomass in wastewater and activated sludge. The relationship between biomass and these activity parameters was established in growth cultures made...... plants, it was found that ATP content and respiration rate estimated viable biomass to range from 81 to 293 mg dw/g SS for raw wastewater and from 67 to 187 mg dw/g SS for activated sludge with a rather weak correlation between ATP and respiration measurements. The FDA hydrolysis estimated viable biomass...

  4. Utilizing Adventure Activities with Intact Groups: A Sociodramatic Systems Approach to Consultation.

    Science.gov (United States)

    Gillis, H. Lee; Bonney, Warren C.

    1989-01-01

    Describes team-building activities for mental health counselors who function as consultants to staffs, groups, or other intact work systems. Provides rationale for application of strategic systems and sociodrama techniques to an adventure activity that allows a group to metaphorically enact its common issue. Provides example of a consultation…

  5. Utility of Acculturation in Physical Activity Research in Latina Adults: An Integrative Review of Literature

    Science.gov (United States)

    Benitez, Tanya J.; Dodgson, Joan E.; Coe, Kathryn; Keller, Colleen

    2016-01-01

    Latina adults in the United States have a disproportionately higher prevalence of chronic diseases related to low physical activity levels than non-Hispanic women. Literature indicates that acculturation may be a contributing factor to being physically active, but the extent of this association remains unclear. An integrative review of literature…

  6. Utility of Acculturation in Physical Activity Research in Latina Adults: An Integrative Review of Literature

    Science.gov (United States)

    Benitez, Tanya J.; Dodgson, Joan E.; Coe, Kathryn; Keller, Colleen

    2016-01-01

    Latina adults in the United States have a disproportionately higher prevalence of chronic diseases related to low physical activity levels than non-Hispanic women. Literature indicates that acculturation may be a contributing factor to being physically active, but the extent of this association remains unclear. An integrative review of literature…

  7. Staphylococcal SplB serine protease utilizes a novel molecular mechanism of activation.

    Science.gov (United States)

    Pustelny, Katarzyna; Zdzalik, Michal; Stach, Natalia; Stec-Niemczyk, Justyna; Cichon, Przemyslaw; Czarna, Anna; Popowicz, Grzegorz; Mak, Pawel; Drag, Marcin; Salvesen, Guy S; Wladyka, Benedykt; Potempa, Jan; Dubin, Adam; Dubin, Grzegorz

    2014-05-30

    Staphylococcal SplB protease belongs to the chymotrypsin family. Chymotrypsin zymogen is activated by proteolytic processing at the N terminus, resulting in significant structural rearrangement at the active site. Here, we demonstrate that the molecular mechanism of SplB protease activation differs significantly and we characterize the novel mechanism in detail. Using peptide and protein substrates we show that the native signal peptide, or any N-terminal extension, has an inhibitory effect on SplB. Only precise N-terminal processing releases the full proteolytic activity of the wild type analogously to chymotrypsin. However, comparison of the crystal structures of mature SplB and a zymogen mimic show no rearrangement at the active site whatsoever. Instead, only the formation of a unique hydrogen bond network, distant form the active site, by the new N-terminal glutamic acid of mature SplB is observed. The importance of this network and influence of particular hydrogen bond interactions at the N terminus on the catalytic process is demonstrated by evaluating the kinetics of a series of mutants. The results allow us to propose a consistent model where changes in the overall protein dynamics rather than structural rearrangement of the active site are involved in the activation process.

  8. Utilization of spent activated carbon to enhance the combustion efficiency of organic sludge derived fuel.

    Science.gov (United States)

    Chen, Wei-Sheng; Lin, Chang-Wen; Chang, Fang-Chih; Lee, Wen-Jhy; Wu, Jhong-Lin

    2012-06-01

    This study examines the heating value and combustion efficiency of organic sludge derived fuel, spent activated carbon derived fuel, and derived fuel from a mixture of organic sludge and spent activated carbon. Spent activated carbon was sampled from an air pollution control device of an incinerator and characterized by XRD, XRF, TG/DTA, and SEM. The spent activated carbon was washed with deionized water and solvent (1N sulfuric acid) and then processed by the organic sludge derived fuel manufacturing process. After washing, the salt (chloride) and sulfide content could be reduced to 99% and 97%, respectively; in addition the carbon content and heating value were increased. Different ratios of spent activated carbon have been applied to the organic sludge derived fuel to reduce the NO(x) emission of the combustion.

  9. Cost utility of behavioural activation delivered by the non-specialist.

    Science.gov (United States)

    Ekers, David; Godfrey, Christine; Gilbody, Simon; Parrott, Steve; Richards, David A; Hammond, Danielle; Hayes, Adele

    2011-12-01

    Behavioural activation by non-specialists appears effective in the treatment of depression. We examined incremental cost-effectiveness of behavioural activation (n = 24) v. treatment as usual (n = 23) in a randomised controlled trial. Intention-to-treat analyses indicated a quality-adjusted life-year (QALY) difference in favour of behavioural activation of 0.20 (95% CI 0.01-0.39, P = 0.042), incremental cost-effectiveness ratio of £5756 per QALY and a 97% probability that behavioural activation is more cost-effective at a threshold value of £20,000. Results are promising for dissemination of behavioural activation but require replication in a larger study.

  10. Utilizing laser interference lithography to fabricate hierarchical optical active nanostructures inspired by the blue Morpho butterfly

    Science.gov (United States)

    Siddique, Radwanul H.; Faisal, Abrar; Hünig, Ruben; Bartels, Carolin; Wacker, Irene; Lemmer, Uli; Hoelscher, Hendrik

    2014-09-01

    The famous non-iridescent blue of the Morpho butter by is caused by a `Christmas tree' like nanostructure which is a challenge for common fabrication techniques. Here, we introduce a method to fabricate this complex morphology utilizing dual beam interference lithography. We add a reflective coating below the photoresist to create a second interference pattern in vertical direction by exploiting the back reflection from the substrate. This vertical pattern exposes the lamella structure into the photosensitive polymer while the horizontal interference pattern determines the distance of the ridges. The photosensitive polymer is chosen accordingly to create the Christmas tree' like tapered shape. The resulting artificial Morpho replica shows brilliant non-iridescent blue up to an incident angle of 40. Its optical properties are close to the original Morpho structure because the refractive index of the polymer is close to chitin. Moreover, the biomimetic surface is water repellent with a contact angle of 110.

  11. Automatic Recognition of Activities of Daily Living utilizing Insole Based and Wrist Worn Wearable Sensors.

    Science.gov (United States)

    Hegde, Nagaraj; Bries, Matthew; Swibas, Tracy; Melanson, Edward; Sazonov, Edward

    2017-08-01

    Automatic recognition of activities of daily living (ADL) is an important component in understanding of energy balance, quality of life and other areas of health and well-being. In our previous work, we had proposed an insole based activity monitor - SmartStep, designed to be socially acceptable and comfortable. The goals of the current study were: first, validation of SmartStep in recognition of a broad set of ADL; second, comparison of the SmartStep to a wrist sensor and testing these in combination; third, evaluation of SmartStep accuracy in measuring wear non-compliance and a novel activity class (driving); fourth, performing the validation in free living against a well-studied criterion measure (ActivPAL, PAL Technologies); and fifth, quantitative evaluation of the perceived comfort of SmartStep. The activity classification models were developed from a laboratory study consisting of 13 different activities under controlled conditions. Leave-one-out cross validation showed 89% accuracy for the combined SmartStep and wrist sensor, 81% for the SmartStep alone, and 69% for the wrist sensor alone. When household activities were grouped together as one class, SmartStep performed equally well compared to the combination of SmartStep and wrist-worn sensor (90% vs 94%) whereas the accuracy of the wrist sensor increased marginally (73% from 69%). SmartStep achieved 92% accuracy in recognition of non-wear and 82% in recognition of driving. Participants then were studied for a day in free-living conditions. The overall agreement with ActivPAL was 82.5% (compared to 97% for the laboratory study). The SmartStep scored the best on the perceived comfort reported at the end of the study. These results suggest that insole-based activity sensors may present a compelling alternative or companion to commonly used wrist devices.

  12. Consistent evaluation of an ultrasound-guided surgical navigation system by utilizing an active validation platform

    Science.gov (United States)

    Kim, Younsu; Kim, Sungmin; Boctor, Emad M.

    2017-03-01

    An ultrasound image-guided needle tracking systems have been widely used due to their cost-effectiveness and nonionizing radiation properties. Various surgical navigation systems have been developed by utilizing state-of-the-art sensor technologies. However, ultrasound transmission beam thickness causes unfair initial evaluation conditions due to inconsistent placement of the target with respect to the ultrasound probe. This inconsistency also brings high uncertainty and results in large standard deviations for each measurement when we compare accuracy with and without the guidance. To resolve this problem, we designed a complete evaluation platform by utilizing our mid-plane detection and time of flight measurement systems. The evaluating system uses a PZT element target and an ultrasound transmitting needle. In this paper, we evaluated an optical tracker-based surgical ultrasound-guided navigation system whereby the optical tracker tracks marker frames attached on the ultrasound probe and the needle. We performed ten needle trials of guidance experiment with a mid-plane adjustment algorithm and with a B-mode segmentation method. With the midplane adjustment, the result showed a mean error of 1.62+/-0.72mm. The mean error increased to 3.58+/-2.07mm without the mid-plane adjustment. Our evaluation system can reduce the effect of the beam-thickness problem, and measure ultrasound image-guided technologies consistently with a minimal standard deviation. Using our novel evaluation system, ultrasound image-guided technologies can be compared under equal initial conditions. Therefore, the error can be evaluated more accurately, and the system provides better analysis on the error sources such as ultrasound beam thickness.

  13. Home uterine activity monitoring: an evidence review of its utility in multiple gestations.

    Science.gov (United States)

    Reichmann, James P

    2009-09-01

    To examine the medical evidence regarding the application of home uterine activity monitoring for multiple gestations. All of the published peer-reviewed articles on the topic were assembled and assigned a level of evidence based on research design. The search uncovered 9 articles, including 3 Level I randomized, controlled trials; 1 level II matched cohort trial; and 5 level III case series. The first 5 trials all showed promising results for home uterine activity monitoring applied to multiple gestations. Ultimately, however, 14 years after the introduction of home uterine activity monitoring, the largest randomized, controlled trial was published, and it demonstrated that pregnancy outcomes were identical for patients with home uterine activity monitoring and patients receiving weekly calls from a nurse. A subsequent National Institute of Child Health and Human Development published trial may provide a clue as to why the large, randomized, controlled trial demonstrated no difference. Contractions in multiple gestations are not predictive of preterm birth.

  14. The utility of the Digi-walker step counter to assess daily physical activity patterns.

    Science.gov (United States)

    Welk, G J; Differding, J A; Thompson, R W; Blair, S N; Dziura, J; Hart, P

    2000-09-01

    The Digi-Walker step counter is a promising and cost-effective tool to measure physical activity under free-living conditions. Two specific studies were conducted to evaluate the number of steps required to meet current physical activity guidelines. Thirty-one adults (17 men, 14 women) served as participants. In study 1, we determined the number of steps to complete a mile under two different conditions and three paces. In study 2, we conducted a field trial to examine the relationship between daily step counts and other indices of physical activity. Participants in this study wore a Digi-Walker for 2 consecutive weeks and completed the 7-d physical activity recall (PAR) after each week. In study 1, there were no differences in step counts by site, but steps were inversely related to pace, with values ranging from 1330 to 1996. Individual step counts at a specific pace were negatively correlated with height, weight, leg length, and stride length and were positively correlated with body fatness. In study 2, participants had average daily step counts of 11,603 when structured vigorous activity was included and 8265 when only light and moderate activity were measured. Modest correlations were found between step counts and estimated energy expenditure. Similar correlations were observed when step counts were related to minutes of activity per day and minutes of sitting per day. Pedometers provide a useful indicator of daily step counts but variability in activity patterns make it difficult to establish step count guidelines that correspond with other public health guidelines.

  15. Improved cartilage regeneration utilizing mesenchymal stem cells in TGF-beta1 gene-activated scaffolds.

    Science.gov (United States)

    Diao, Huajia; Wang, Jinliang; Shen, Chao; Xia, Suhua; Guo, Ting; Dong, Lei; Zhang, Chenyu; Chen, Jiangning; Zhao, Jianning; Zhang, Junfeng

    2009-09-01

    Recently, bone marrow-derived mesenchymal stem cells (MSCs) have been paid more attention for cartilage regeneration. This study evaluated the potential of using MSCs seeded in plasmid transforming growth factor beta1 (pTGF-beta1)-activated three-dimensional chitosan/gelatin scaffolds for improving cartilage repair in vivo. Significant cell proliferation and transforming growth factor beta1 protein expression were observed in vitro in pTGFbeta1-activated scaffolds. Transforming growth factor beta1-activated scaffolds showed high collagen type II and aggrecan expression and low collagen type I expression during in vitro cultivation. MSC-based pTGF-beta1-activated scaffolds also exhibited cartilage histology with high secretion of collagen type II in vitro under the stimulation of pTGF-beta1. In rabbits with full-thickness cartilage defects, the implantation of MSC-based pTGF-beta1-activated scaffolds not only significantly promoted chondrogenic differentiation of MSCs and hyalin-like cartilage matrix synthesis, but also remarkably improved the overall repair of rabbit cartilage defects and exhibited favorable tissue integrity at 10 weeks postsurgery. These results suggest that MSC-based localized pTGF-beta1-activated scaffolds have potential applications for in vivo cartilage repair.

  16. Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid.

    Science.gov (United States)

    Hinz, Christine; Aldrovandi, Maceler; Uhlson, Charis; Marnett, Lawrence J; Longhurst, Hilary J; Warner, Timothy D; Alam, Saydul; Slatter, David A; Lauder, Sarah N; Allen-Redpath, Keith; Collins, Peter W; Murphy, Robert C; Thomas, Christopher P; O'Donnell, Valerie B

    2016-06-24

    Eicosanoids are important mediators of fever, pain, and inflammation that modulate cell signaling during acute and chronic disease. We show by using lipidomics that thrombin-activated human platelets generate a new type of eicosanoid that both stimulates and primes human neutrophil integrin (Mac-1) expression, in response to formylmethionylleucylphenylalanine. Detailed characterization proposes a dioxolane structure, 8-hydroxy-9,11-dioxolane eicosatetraenoic acid (dioxolane A3, DXA3). The lipid is generated in nanogram amounts by platelets from endogenous arachidonate during physiological activation, with inhibition by aspirin in vitro or in vivo, implicating cyclooxygenase-1 (COX). Pharmacological and genetic studies on human/murine platelets revealed that DXA3 formation requires protease-activated receptors 1 and 4, cytosolic phospholipase A2 (cPLA2), Src tyrosine kinases, p38 MAPK, phospholipase C, and intracellular calcium. From data generated by purified COX isoforms and chemical oxidation, we propose that DXA3 is generated by release of an intermediate from the active site followed by oxygenation at C8. In summary, a new neutrophil-activating platelet-derived lipid generated by COX-1 is presented that can activate or prime human neutrophils, suggesting a role in innate immunity and acute inflammation.

  17. Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid*

    Science.gov (United States)

    Hinz, Christine; Aldrovandi, Maceler; Uhlson, Charis; Marnett, Lawrence J.; Longhurst, Hilary J.; Warner, Timothy D.; Alam, Saydul; Slatter, David A.; Lauder, Sarah N.; Allen-Redpath, Keith; Collins, Peter W.; Murphy, Robert C.; Thomas, Christopher P.; O'Donnell, Valerie B.

    2016-01-01

    Eicosanoids are important mediators of fever, pain, and inflammation that modulate cell signaling during acute and chronic disease. We show by using lipidomics that thrombin-activated human platelets generate a new type of eicosanoid that both stimulates and primes human neutrophil integrin (Mac-1) expression, in response to formylmethionylleucylphenylalanine. Detailed characterization proposes a dioxolane structure, 8-hydroxy-9,11-dioxolane eicosatetraenoic acid (dioxolane A3, DXA3). The lipid is generated in nanogram amounts by platelets from endogenous arachidonate during physiological activation, with inhibition by aspirin in vitro or in vivo, implicating cyclooxygenase-1 (COX). Pharmacological and genetic studies on human/murine platelets revealed that DXA3 formation requires protease-activated receptors 1 and 4, cytosolic phospholipase A2 (cPLA2), Src tyrosine kinases, p38 MAPK, phospholipase C, and intracellular calcium. From data generated by purified COX isoforms and chemical oxidation, we propose that DXA3 is generated by release of an intermediate from the active site followed by oxygenation at C8. In summary, a new neutrophil-activating platelet-derived lipid generated by COX-1 is presented that can activate or prime human neutrophils, suggesting a role in innate immunity and acute inflammation. PMID:27129261

  18. PERK Utilizes Intrinsic Lipid Kinase Activity To Generate Phosphatidic Acid, Mediate Akt Activation, and Promote Adipocyte Differentiation

    Science.gov (United States)

    Bobrovnikova-Marjon, Ekaterina; Pytel, Dariusz; Riese, Matthew J.; Vaites, Laura Pontano; Singh, Nickpreet; Koretzky, Gary A.; Witze, Eric S.

    2012-01-01

    The endoplasmic reticulum (ER) resident PKR-like kinase (PERK) is necessary for Akt activation in response to ER stress. We demonstrate that PERK harbors intrinsic lipid kinase, favoring diacylglycerol (DAG) as a substrate and generating phosphatidic acid (PA). This activity of PERK correlates with activation of mTOR and phosphorylation of Akt on Ser473. PERK lipid kinase activity is regulated in a phosphatidylinositol 3-kinase (PI3K) p85α-dependent manner. Moreover, PERK activity is essential during adipocyte differentiation. Because PA and Akt regulate many cellular functions, including cellular survival, proliferation, migratory responses, and metabolic adaptation, our findings suggest that PERK has a more extensive role in insulin signaling, insulin resistance, obesity, and tumorigenesis than previously thought. PMID:22493067

  19. PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation.

    Science.gov (United States)

    Bobrovnikova-Marjon, Ekaterina; Pytel, Dariusz; Riese, Matthew J; Vaites, Laura Pontano; Singh, Nickpreet; Koretzky, Gary A; Witze, Eric S; Diehl, J Alan

    2012-06-01

    The endoplasmic reticulum (ER) resident PKR-like kinase (PERK) is necessary for Akt activation in response to ER stress. We demonstrate that PERK harbors intrinsic lipid kinase, favoring diacylglycerol (DAG) as a substrate and generating phosphatidic acid (PA). This activity of PERK correlates with activation of mTOR and phosphorylation of Akt on Ser473. PERK lipid kinase activity is regulated in a phosphatidylinositol 3-kinase (PI3K) p85α-dependent manner. Moreover, PERK activity is essential during adipocyte differentiation. Because PA and Akt regulate many cellular functions, including cellular survival, proliferation, migratory responses, and metabolic adaptation, our findings suggest that PERK has a more extensive role in insulin signaling, insulin resistance, obesity, and tumorigenesis than previously thought.

  20. Utilizing avidity to improve antifreeze protein activity: a type III antifreeze protein trimer exhibits increased thermal hysteresis activity.

    Science.gov (United States)

    Can, Özge; Holland, Nolan B

    2013-12-03

    Antifreeze proteins (AFPs) are ice growth inhibitors that allow the survival of several species living at temperatures colder than the freezing point of their bodily fluids. AFP activity is commonly defined in terms of thermal hysteresis, which is the difference observed for the solution freezing and melting temperatures. Increasing the thermal hysteresis activity of these proteins, particularly at low concentrations, is of great interest because of their wide range of potential applications. In this study, we have designed and expressed one-, two-, and three-domain antifreeze proteins to improve thermal hysteresis activity through increased binding avidity. The three-domain type III AFP yielded significantly greater activity than the one- and two-domain proteins, reaching a thermal hysteresis of >1.6 °C at a concentration of hysteresis activity.

  1. Utility of Accelerometers to Measure Physical Activity in Children Attending an Obesity Treatment Intervention

    Directory of Open Access Journals (Sweden)

    Wendy Robertson

    2011-01-01

    Full Text Available Objectives. To investigate the use of accelerometers to monitor change in physical activity in a childhood obesity treatment intervention. Methods. 28 children aged 7–13 taking part in “Families for Health” were asked to wear an accelerometer (Actigraph for 7-days, and complete an accompanying activity diary, at baseline, 3-months and 9-months. Interviews with 12 parents asked about research measurements. Results. Over 90% of children provided 4 days of accelerometer data, and around half of children provided 7 days. Adequately completed diaries were collected from 60% of children. Children partake in a wide range of physical activity which uniaxial monitors may undermonitor (cycling, nonmotorised scootering or overmonitor (trampolining. Two different cutoffs (4 METS or 3200 counts⋅min-1 for minutes spent in moderate and vigorous physical activity (MVPA yielded very different results, although reached the same conclusion regarding a lack of change in MVPA after the intervention. Some children were unwilling to wear accelerometers at school and during sport because they felt they put them at risk of stigma and bullying. Conclusion. Accelerometers are acceptable to a majority of children, although their use at school is problematic for some, but they may underestimate children's physical activity.

  2. ECUT: Energy Conversion and Utilization Technologies Program. Biocatalysis Research Activity annual report, FY 1983

    Energy Technology Data Exchange (ETDEWEB)

    1984-04-15

    The activities of the Biocatalysis Research Activity during FY 1983 were organized into the Biocatalysis and Molecular Modeling work elements and a supporting planning and analysis function. In the biocatalysis work element, progress was made in developing a method for stabilizing genetically engineered traits in microorganisms, refining a technique for monitoring cells that have been genetically engineered, identifying strains of fungi for highly efficient preprocessing of biomass for biocatalyzed processes, and determining molecular level conditions for optimizing the efficiency of bioreactors. In the Molecular Modeling work element, a preliminary model of the behavior of enzymes was developed. Also, a preliminary investigation of the potential for synthesizing enzymes for use in electrochemical processes was completed. As part of the Activity's supporting planning and analysis efforts, contact with industry and universities was made to define key biocatalysis technical issues and to broaden the range of potential participants in the Activity. Additionally, analyses were conducted to identify and evaluate potential concepts for future research funding by the Activity. 1 figure, 2 tables.

  3. Green Urban Space Utilization for Mild ICT-Based Touristic Activities: The Case of Pafsilipo Park in Greece

    Directory of Open Access Journals (Sweden)

    Stefanos KARAGIANNIS

    2014-11-01

    Full Text Available This paper discusses the issue of mild touristic activities in green urban landscapes. More specifically, it uses the case of Pasfilipo Park in the city of Karditsa, Greece, where a green urban landscape has been utilized for local life improvement and illustrates existing touristic activities in this area. For the purposes of strengthening landscape’s role, various touristic activities are proposed accompanied by Information and Communications Technologies (ICT. Moreover, this paper queries scientific issues with regard to the capitalization of green urban spaces for small scale touristic and ecological activities, which support local life and local economic growth. This study addresses the above modern requirements for urban development with respect to existing natural and human resources. It attempts to answer the following question: can green open spaces in cities be capitalized for touristic activities that support sustainable growth? In this order, green spaces in cities are recognized as areas for smart growth, where mild touristic activities can be undertaken without ecologic damages and can result in simultaneous economic activities that can lead to local development.

  4. The reported clinical utility of taurine in ischemic disorders may reflect a down-regulation of neutrophil activation and adhesion.

    Science.gov (United States)

    McCarty, M F

    1999-10-01

    The first publications regarding clinical use of taurine were Italian reports claiming therapeutic efficacy in angina, intermittent claudication and symptomatic cerebral arteriosclerosis. A down-regulation of neutrophil activation and endothelial adhesion might plausibly account for these observations. Endothelial platelet-activating factor (PAF) is a crucial stimulus to neutrophil adhesion and activation, whereas endothelial nitric oxide (NO) suppresses PAF production and acts in various other ways to antagonize binding and activation of neutrophils. Hypochlorous acid (HOCl), a neutrophil product which avidly oxidizes many sulfhydryl-dependent proteins, can be expected to inhibit NO synthase while up-regulating PAF generation; thus, a vicious circle can be postulated whereby HOCl released by marginating neutrophils acts on capillary or venular endothelium to promote further neutrophil adhesion and activation. Taurine is the natural detoxicant of HOCl, and thus has the potential to intervene in this vicious circle, promoting a less adhesive endothelium and restraining excessive neutrophil activation. Agents which inhibit the action of PAF on neutrophils, such as ginkgolides and pentoxifylline, have documented utility in ischemic disorders and presumably would complement the efficacy of taurine in this regard. Fish oil, which inhibits endothelial expression of various adhesion factors and probably PAF as well, and which suppresses neutrophil leukotriene production, may likewise be useful in ischemia. These agents may additionally constitute a non-toxic strategy for treating inflammatory disorders in which activated neutrophils play a prominent pathogenic role. Double-blind studies to confirm the efficacy of taurine in symptomatic chronic ischemia are needed.

  5. Lignocellulolytic enzyme activity, substrate utilization, and mushroom yield by Pleurotus ostreatus cultivated on substrate containing anaerobic digester solids.

    Science.gov (United States)

    Isikhuemhen, Omoanghe S; Mikiashvilli, Nona A

    2009-11-01

    Solid waste from anaerobic digestion of litter from the commercial production of broiler chickens has limited use as fertilizer. Its disposal is a major problem for digester operators who are seeking alternative use for anaerobic digester solids, also referred to as solid waste (SW). The use of SW as substrates for the cultivation of Pleurotus ostreatus strain MBFBL400 was investigated. Lignocellulolytic enzymes activity, substrate utilization, and mushroom yield were evaluated in ten different substrate combinations (SCs) containing varying amounts of solid waste, wheat straw, and millet. Nutritional content of mushrooms produced on the different substrates was also determined. Substrates containing 70-80% wheat straw, 10-20% SW, and 10-20% millet were found to produce the highest mushroom yield (874.8-958.3 g/kg). Loss of organic matter in all SCs tested varied from 45.8% to 56.2%, which had positive correlation with the biological efficiency. Laccase, peroxidase, and carboxymethylcellulase (CMCase) activities were higher before fruiting, whereas xylanase showed higher activities after mushroom fruiting. SW increased the nutritional content in mushrooms harvested, and the combination of wheat straw and SW with millet significantly improved mushroom yield. Our findings demonstrated the possibility of utilizing anaerobic digester solids in mushroom cultivation. The application of SW as such could improve the financial gains in the overall economy of anaerobic digester plants.

  6. The Utility of the OMI HCHO/NO2 in Air Quality Decision-Making Activities

    Science.gov (United States)

    Duncan, Bryan

    2010-01-01

    I will discuss a novel and practical application of the OMI HCHU and NO2 data products to the "weight of evidence" in the air quality decision-making process (e.g., State Implementation Plan (SIP)) for a city, region, or state to demonstrate that it is making progress toward attainment of the National Ambient Air Quality Standard (NAAQS) for ozone. Any trend, or lack thereof, in the observed OMI HCHO/NO2 may support that an emission control strategy implemented to reduce ozone is or is not occurring for a metropolitan area. In addition, the observed OMI HCHO/NO2 may be used to define new emission control strategies as the photochemical environments of urban areas evolve over time. I will demonstrate the utility of the OMI HCHO/NO2 over the U.S. for air quality applications with support from simulations with both a regional model and a photochemical box model. These results support mission planning of an OMI-like instrument for the proposed GEO-CAPE satellite that has as one of its objectives to study air quality from space. However, I'm attending the meeting as the Aura Deputy Project Scientist, so I don't technically need to present anything to justify the travel.

  7. Utilization of Enzyme-Immobilized Mesoporous Silica Nanocontainers (IBN-4 in Prodrug-Activated Cancer Theranostics

    Directory of Open Access Journals (Sweden)

    Bau-Yen Hung

    2015-12-01

    Full Text Available To develop a carrier for use in enzyme prodrug therapy, Horseradish peroxidase (HRP was immobilized onto mesoporous silica nanoparticles (IBN-4: Institute of Bioengineering and Nanotechnology, where the nanoparticle surfaces were functionalized with 3-aminopropyltrimethoxysilane and further conjugated with glutaraldehyde. Consequently, the enzymes could be stabilized in nanochannels through the formation of covalent imine bonds. This strategy was used to protect HRP from immune exclusion, degradation and denaturation under biological conditions. Furthermore, immobilization of HRP in the nanochannels of IBN-4 nanomaterials exhibited good functional stability upon repetitive use and long-term storage (60 days at 4 °C. The generation of functionalized and HRP-immobilized nanomaterials was further verified using various characterization techniques. The possibility of using HRP-encapsulated IBN-4 materials in prodrug cancer therapy was also demonstrated by evaluating their ability to convert a prodrug (indole-3- acetic acid (IAA into cytotoxic radicals, which triggered tumor cell apoptosis in human colon carcinoma (HT-29 cell line cells. A lactate dehydrogenase (LDH assay revealed that cells could be exposed to the IBN-4 nanocomposites without damaging their membranes, confirming apoptotic cell death. In summary, we demonstrated the potential of utilizing large porous mesoporous silica nanomaterials (IBN-4 as enzyme carriers for prodrug therapy.

  8. The Utility of the OMI HCHO/NO2 in Air Quality Decision-Making Activities

    Science.gov (United States)

    Duncan, Bryan

    2010-01-01

    I will discuss a novel and practical application of the OMI HCHU and NO2 data products to the "weight of evidence" in the air quality decision-making process (e.g., State Implementation Plan (SIP)) for a city, region, or state to demonstrate that it is making progress toward attainment of the National Ambient Air Quality Standard (NAAQS) for ozone. Any trend, or lack thereof, in the observed OMI HCHO/NO2 may support that an emission control strategy implemented to reduce ozone is or is not occurring for a metropolitan area. In addition, the observed OMI HCHO/NO2 may be used to define new emission control strategies as the photochemical environments of urban areas evolve over time. I will demonstrate the utility of the OMI HCHO/NO2 over the U.S. for air quality applications with support from simulations with both a regional model and a photochemical box model. These results support mission planning of an OMI-like instrument for the proposed GEO-CAPE satellite that has as one of its objectives to study air quality from space. However, I'm attending the meeting as the Aura Deputy Project Scientist, so I don't technically need to present anything to justify the travel.

  9. Enzyme Activities in Oleaginous Yeasts Accumulating and Utilizing Exogenous or Endogenous Lipids

    NARCIS (Netherlands)

    Holdsworth, Jane E.; Veenhuis, Marten; Ratledge, Colin

    1988-01-01

    The activities of ATP:citrate lyase (ACL; EC 4.1.3.8), carnitine acetyltransferase (CAT; EC 2.3.1.7), NADP+-dependent isocitrate dehydrogenase (ICDH; EC 1.1.1.42), isocitrate lyase (ICL; EC 4.1.3.1) and malic enzyme (malate dehydrogenase; EC 1.1.1.40) were measured in four oleaginous yeasts, Candida

  10. Utilizing the Active and Collaborative Learning Model in the Introductory Physics Course

    Science.gov (United States)

    Nam, Nguyen Hoai

    2014-01-01

    Model of active and collaborative learning (ACLM) applied in training specific subject makes clear advantage due to the goals of knowledge, skills that students got to develop successful future job. The author exploits the learning management system (LMS) of Hanoi National University of Education (HNUE) to establish a learning environment in the…

  11. Utilizing Technology to Improve the Administration of Instructional Physical Activity Programs in Higher Education

    Science.gov (United States)

    Melton, Bridget; Burdette, Trey

    2011-01-01

    The purpose of this article is to provide examples of how technology is being used in one university to increase the organization and effectiveness of instructional physical activity programs (IPAPs). The article outlines ways in which technology can organize materials for students, instructors, and programs. Additionally, the article describes…

  12. Utilization of quail and chicken embryos for the detection of botulinum toxin type A activity

    Science.gov (United States)

    Clostridium botulinum is a ubiquitous microorganism which can produce botulinum toxins and the ability to assess toxin activity in a food sample is critical. As an alternative to the mouse assay incubating quail (Coturnix coturnix japonica) and chicken (Gallus gallus domestics) embryos were evaluat...

  13. Utilizing Generalization Tactics to Promote Leisure-Time Physical Activity for Students with Intellectual Disabilities

    Science.gov (United States)

    Haegele, Justin A.; Park, Seung Yeon

    2016-01-01

    Research suggests that school-aged individuals with intellectual disabilities (ID) tend to be less physically active than their typically developing peers (e.g., Shields, King, Corbett, & Imms, 2014). While these students can be successful in acquiring motor and sport-related skills during physical education, they tend not to use those skills…

  14. Preparation of Nickel/Active Carboncatalyst and its Utilization for Benzene Hydrogenation

    Directory of Open Access Journals (Sweden)

    Enggelena Septiawati

    2010-06-01

    Full Text Available The research on the preparation of nickel catalyst impregnated on active carbon by two methods has been carried out. The impregnation of Ni metal was done using nickel(II chloride as a precursor. The impregnated of Ni metal on samples in A method was made in varying of percentage i.e., 0.5, 1.0 and 2.0% (w/w as the weight proportion of Ni to active carbon and NiCl2.6H20. The concentration of Ni that would be impregnated on samples in B method was made close to Ni content of samples in A method determined by atomic adsorption spectrometry. Preparation of nickel/active carbon catalyst with A method was done with dipping the active carbon in the nickel(II chloride solution followed by filtering and then drying at 110 °C for 4 hours, and then calcination by flowing nitrogen and reduction by hydrogen, each at 400 °C at 4 hours. The treatments made on samples in A method was also done on samples in B method, the only difference was evaporating all of precursor solution after dipping active carbon in that precursor solution was done in B method. The characterization includes: iodium adsorption test, determination of nickel content by means of atomic adsorption spectrometry, and acidity by adsorption of ammonia methods. Test of catalyst activity was done by means of hydrogenation of benzene to cyclohexane at 150, 200 and 250 °C, the pressure of 1 atm and the flow rate of hydrogen 6 mL/minute. The products were analyzed by gas chromatographic method. The results show that A method produced a catalyst with relatively low nickel content. However the acidity and ability to convert benzene to cyclohexane were relatively high and it increased as increasing the content of nickel. The temperature of the reaction was achieved at 250 °C which gave the yield on conversion of 25.3678%. The catalyst obtained by B method in the same condition of hydrogenation gave only smaller results.

  15. Analysis of Platinum Content in Used Auto Catalytic Converter Carriers and the Possibility of its Recovery

    Directory of Open Access Journals (Sweden)

    Saternus M.

    2014-06-01

    Full Text Available Obecnie każdy wyprodukowany samochód musi być wyposażony w katalizator, w którym metale szlachetne takie jak platyna, pallad czy rod pełnią funkcje katalityczne. Czas życia katalizatorów jest ograniczony, zatem zostają one zastąpione nowymi, a stare stanowią ważne źródło platynowców. Zużyte katalizatory samochodowe przerabiane są hydrometalurgicznie lub pirometalurgicznie. Jednakże pierwszym etapem takiego przerobu powinna być analiza chemiczna. W pracy analizie na zawartość platyny poddano kilka różnych nośników katalitycznych pochodzących z różnych samochodów. Do tego celu posłużył elektronowy mikroskop skaningowy. Przedstawiono strukturę analizowanych nośników katalitycznych, ich analizę chemiczną jak również wykresy EDS (Energy Dispersive Spectrum. Przeprowadzono dyskusję wyników i możliwych metod odzysku platyny.

  16. Hydrogen Recombination Rates of Plate-type Passive Auto-catalytic Recombiner

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jongtae; Hong, Seong-Wan [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kim, Gun Hong [Kyungwon E-C Co., Seongnam (Korea, Republic of)

    2014-10-15

    The hydrogen mitigation system may include igniters, passive autocatalytic recombiner (PAR), and venting or dilution system. Recently PAR is commonly used as a main component of HMS in a NPP containment because of its passive nature. PARs are categorized by the shape and material of catalytic surface. Catalytic surface coated by platinum is mostly used for the hydrogen recombiners. The shapes of the catalytic surface can be grouped into plate type, honeycomb type and porous media type. Among them, the plate-type PAR is well tested by many experiments. PAR performance analysis can be approached by a multi-scale method which is composed of micro, meso and macro scales. The criterion of the scaling is the ratio of thickness of boundary layer developed on a catalytic surface to representative length of a computational domain. Mass diffusion in the boundary layer must be resolved in the micro scale analysis. In a lumped parameter (LP) analysis using a system code such as MAAP or MELCOR, the chamber of the PAR is much smaller than a computational node. The hydrogen depletion by a PAR is modeled as a source of mass and energy conservation equations. Te catalytic surface reaction of hydrogen must be modeled by a volume-averaged correlation. In this study, a micro scale analysis method is developed using libraries in OpenFOAM to evaluate a hydrogen depletion rate depending on parameters such as size and number of plates and plate arrangement. The analysis code is validated by simulating REKO-3 experiment. And hydrogen depletion analysis is conducted by changing the plate arrangement as a trial of the performance enhancement of a PAR. In this study, a numerical code for an analysis of a PAR performance in a micro scale has been developed by using OpenFOAM libraries. The physical and numerical models were validated by simulating the REKO-3 experiment. As a try to enhance the performance of the plate-type PAR, it was proposed to apply a staggered two-layer arrangement of the catalytic plates. The hydrogen concentration at PAR exit was calculated using the developed numerical method.

  17. Utilization of ko-factors for quality assurance in neutron activation analysis

    DEFF Research Database (Denmark)

    Heydorn, K.; Damsgaard, E.

    1994-01-01

    Multielement certification analysis by instrumental neutron activation analysis requires simultaneous irradiation of several elemental comparator standards in order to ascertain traceability. Internal consistency of different comparators may be checked by calculation of k0-ratios, which show large...... deviations from unity in case of stoichiometric or other gross errors. Quality assurance based on the Analysis of Precision of k0-ratios from replicate analyses detects unexpected variability associated with inaccurate comparator standards. In two actual cases of cerification lack of statistical control...

  18. Human platelets utilize cycloxygenase-1 to generate dioxolane A3, a neutrophil activating eicosanoid

    OpenAIRE

    Hinz, Christine; Aldrovandi, MacEler; Alam, Saydul; Slatter, David; Lauder, Sarah Nicol; Allen-Redpath, Keith; Collins, Peter William; Thomas, Christopher P.; O'Donnell, Valerie Bridget

    2016-01-01

    Eicosanoids are important mediators of fever, pain, and inflammation that modulate cell signaling during acute and chronic disease. We show by using lipidomics that thrombin-activated human platelets generate a new type of eicosanoid that both stimulates and primes human neutrophil integrin (Mac-1) expression, in response to formylmethionylleucylphenylalanine. Detailed characterization proposes a dioxolane structure, 8-hydroxy-9,11-dioxolane eicosatetraenoic acid (dioxolane A3, DXA3). The lip...

  19. Antimicrobial Activity and Phytochemical Analysis of Citrus Fruit Peels -Utilization of Fruit Waste

    OpenAIRE

    K. Ashok Kumar; Narayani, M.; A. Subanthini; Jayakumar, M.

    2011-01-01

    Antibacterial activity of five different solvent extracts(ethyl acetate, acetone, ethanol, petroleum ether and water) prepared by soxhlet extractor from two citrus fruit peel (Citrus sinensis and Citrus limon) were screened against five pathogenic bacteria Staphylococcus aureus, Bacillus subtilis, Escherichia coli , Klebsiella pneumonia and Salmonella typhi. The highest antibacterial potentiality was exhibited by the acetone peel extract of Citrus sinensis followed by the ethyl acetate peel e...

  20. Maximizing semi-active vibration isolation utilizing a magnetorheological damper with an inner bypass configuration

    Energy Technology Data Exchange (ETDEWEB)

    Bai, Xian-Xu, E-mail: bai@hfut.edu.cn [Department of Vehicle Engineering, Hefei University of Technology, Hefei 230009 (China); Wereley, Norman M.; Hu, Wei [Department of Aerospace Engineering, University of Maryland, College Park, Maryland 20742 (United States)

    2015-05-07

    A single-degree-of-freedom (SDOF) semi-active vibration control system based on a magnetorheological (MR) damper with an inner bypass is investigated in this paper. The MR damper employing a pair of concentric tubes, between which the key structure, i.e., the inner bypass, is formed and MR fluids are energized, is designed to provide large dynamic range (i.e., ratio of field-on damping force to field-off damping force) and damping force range. The damping force performance of the MR damper is modeled using phenomenological model and verified by the experimental tests. In order to assess its feasibility and capability in vibration control systems, the mathematical model of a SDOF semi-active vibration control system based on the MR damper and skyhook control strategy is established. Using an MTS 244 hydraulic vibration exciter system and a dSPACE DS1103 real-time simulation system, experimental study for the SDOF semi-active vibration control system is also conducted. Simulation results are compared to experimental measurements.

  1. Synthesis of 6,8-dichloroquinolones utilizing new method and evaluation of their antibacterial activities

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Several 6,8-dichloroquinolone analogues were synthesized from the key intermediate compound of 2,3,4,5-tetrachlorobenzene carbonyl chloride, which was obtained from the starting material of tetrachlorophthalic anhydride. Their in vitro antibacterial activities were evaluated. As a result of this study, compounds 21c and 21d were twofold more potent than ciprofloxacin (CPFX)and norfloxacin (NFLX) against Staphylococcus aureus-9, and with the same potent as CPFX and NFLX while against Escherichia coli-2, but were less potent than references in against Pseudomonas aeruginosa-17.

  2. Phase Preference by Active, Acetate-Utilizing Bacteria at the Rifle, CO Integrated Field Research Challenge Site

    Energy Technology Data Exchange (ETDEWEB)

    Kerkhof, L.; Williams, K.H.; Long, P.E.; McGuinness, L.

    2011-02-21

    Previous experiments at the Rifle, Colorado Integrated Field Research Challenge (IFRC) site demonstrated that field-scale addition of acetate to groundwater reduced the ambient soluble uranium concentration. In this report, sediment samples collected before and after acetate field addition were used to assess the active microbes via {sup 13}C acetate stable isotope probing on 3 phases [coarse sand, fines (8-approximately 150 {micro}m), groundwater (0.2-8 {micro}m)] over a 24-day time frame. TRFLP results generally indicated a stronger signal in {sup 13}C-DNA in the 'fines' fraction compared to the sand and groundwater. Before the field-scale acetate addition, a Geobacter-like group primarily synthesized {sup 13}C-DNA in the groundwater phase, an alpha Proteobacterium primarily grew on the fines/sands, and an Acinetobacter sp. and Decholoromonas-like OTU utilized much of the {sup 13}C acetate in both groundwater and particle-associated phases. At the termination of the field-scale acetate addition, the Geobacter-like species was active on the solid phases rather than the groundwater, while the other bacterial groups had very reduced newly synthesized DNA signal. These findings will help to delineate the acetate utilization patterns of bacteria in the field and can lead to improved methods for stimulating distinct microbial populations in situ.

  3. Phase Preference by Active, Acetate-Utilizing Bacteria at the Rifle, CO Integrated Field Research Challenge Site

    Energy Technology Data Exchange (ETDEWEB)

    Kerkhoff, Lee; Williams, Kenneth H.; Long, Philip E.; McGuinness, L.

    2011-02-15

    Uranium contaminated groundwaters are a legacy concern for the U.S. Department of Energy. Previous experiments at the Rifle, Colorado Integrated Field Challenge (IFC) site have demonstrated that field-scale addition of acetate to groundwater reduces the ambient soluable uranium concentration, sequestering the radionuclide as uraninite. However, questions remain regarding which microorganism(s) are consuming this acetate and if active groundwater microorganisms are different from active particle-associated bacteria. In this report, 13-C acetate was used to assess the active microbes that synthesize DNA on 3 size fractions [coarse sand, fines (8-approximately 150 micron), groundwater (0.2-8 micron)] over a 24 -day time frame. Results indicated a stronger signal from 13-C acetate associated with the “fines” fraction compared with smaller amounts of 13-C uptake on the sand fraction and groundwater samples during the SIP incubations. TRFLP analysis of this 13-C-labeled DNA, indicated 31+ 9 OTU's with 6 peaks dominating the active profiles (166, 187, 210, 212, and 277 bp peaks using MnlI). Cloning/sequencing of the amplification products indicated a Geobacter-like group (187, 210, 212 bp) primarily synthesized DNA from acetate in the groundwater phase, an alpha Proteobacterium (166 bp) primarily grew on the fines/sands, and an Acinetobacter sp. (277 bp) utilized much of the 13C acetate in both groundwater and particle-associated phases. These findings will help to delineate the acetate utilization patterns of bacteria during field-scale acetate addition and can lead to improved methods for stimulating distinct microbial populations in situ.

  4. The Utilization of Waste Date Seed as Bio-Oil and Activated Carbon by Pyrolysis Process

    Directory of Open Access Journals (Sweden)

    Mohammad Uzzal Hossain Joardder

    2012-01-01

    Full Text Available The renovation of biomass waste in the form of date seed waste into activated carbon and biofuel by fixed bed pyrolysis reactor has been focused in this study to obtain gaseous, liquid, and solid products. The date seed in particle form is pyrolysed in an externally heated fixed bed reactor with nitrogen as the carrier gas. The reactor is heated from 400°C to 600°C. A maximum liquid yield of 50 wt.% and char of 30 wt.% are obtained at a reactor bed temperature of 500°C with a running time of 120 minutes. The oil is found to possess favorable flash point and reasonable density and viscosity. The higher calorific value is found to be 28.636 MJ/kg which is significantly higher than other biomass derived. Decolonization of 85–97% is recorded for the textile effluent and 75–90% for the tannery effluent, in all cases decreasing with temperature increase. Good adsorption capacity of the prepared activated carbon in case of diluted textile and tannery effluent was found.

  5. Antimicrobial Activity and Phytochemical Analysis of Citrus Fruit Peels -Utilization of Fruit Waste

    Directory of Open Access Journals (Sweden)

    K. Ashok kumar

    2011-06-01

    Full Text Available Antibacterial activity of five different solvent extracts(ethyl acetate, acetone, ethanol, petroleum ether and water prepared by soxhlet extractor from two citrus fruit peel (Citrus sinensis and Citrus limon were screened against five pathogenic bacteria Staphylococcus aureus, Bacillus subtilis, Escherichia coli , Klebsiella pneumonia and Salmonella typhi. The highest antibacterial potentiality was exhibited by the acetone peel extract of Citrus sinensis followed by the ethyl acetate peel extract of Citrus limon. The peel extract of Citrus sinensis and Citrus limon can be considered to be as equally potent as the antibiotics, such as metacillin and penicillin. MICs were tested at concentrations ranging from 50-6.25 mg/ml as wells as their MBCs. The phytochemical analysis of the citrus peel extracts showed the presence of flavonoids, saponins, steroids, terpenoids, tannins and alkaloids

  6. Utilization of granular activated carbon adsorber for nitrates removal from groundwater of the Cluj region.

    Science.gov (United States)

    Moşneag, Silvia C; Popescu, Violeta; Dinescu, Adrian; Borodi, George

    2013-01-01

    The level of nitrates from groundwater from Cluj County and other areas from Romania have increased values, exceeding or getting close to the allowed limit values, putting in danger human and animal heath. In this study we used granular activated carbon adsorbent (GAC) for nitrate (NO(-)3) removal for the production of drinking water from groundwater of the Cluj county. The influences of the contact time, nitrate initial concentration, and adsorbent concentration have been studied. We determined the equilibrium adsorption capacity of GAC, used for NO(-)3 removal and we applied the Langmuir and Freundlich isotherm models. Ultraviolet-visible (UV-Vis) and Fourier transform infrared (FTIR) spectroscopy, X ray diffraction (XRD), Scanning Electron Microscopy (SEM) were used for process characterization. We also determined: pH, conductivity, Total Dissolved Solids and Total Hardness. The GAC adsorbents have excellent capacities of removing nitrate from groundwater from Cluj County areas.

  7. Utilization of activated carbon for the removal of basic dyes in fixed-bed microcolumn

    Energy Technology Data Exchange (ETDEWEB)

    El Qada, Emad N. [Department of Chemical Engineering Technology, Yanbu Industrial College, Yanbu, P.O. Box 30346 (Saudi Arabia); Abdelghany, Emad A.; Magdy, Yehia H. [Chemical Eng. Dept., Faculty of Eng., Minia University, Minia, P.O. Box 61519 (Egypt)

    2013-07-01

    Liquid-phase adsorption processes were performed using basic dyes (methylene blue (MB), basic red (BR) and basic yellow (BY)) in an activated carbon microcolumn. The effects of initial dye concentration, column diameter and particle size were investigated. The performance of the fixed-bed adsorber was evaluated through the concept of breakthrough curves. The Thomas model was employed to predict the breakthrough curves and compared with the experimental breakthrough curves. Furthermore, the Empty Bed Residence Time (EBRT) has been applied to the data to determine the minimum residence time and the minimum adsorbent exhaustion rate. Column studies showed effective use of adsorbents. The results reflected the significance of the experimental parameters on the efficient removal of basic dyes from aqueous solution. The Thomas model predicts the experimental data well.

  8. Trends in resource utilization and prescription of anticonvulsants for patients with active epilepsy in Germany.

    Science.gov (United States)

    Strzelczyk, Adam; Haag, Anja; Reese, Jens P; Nickolay, Tanja; Oertel, Wolfgang H; Dodel, Richard; Knake, Susanne; Rosenow, Felix; Hamer, Hajo M

    2013-06-01

    This study evaluated trends in the resource use of patients with active epilepsy over a 5-year period at an outpatient clinic of a German epilepsy center. Two cross-sectional cohorts of consecutive adults with active epilepsy were evaluated over a 3-month period in 2003 and 2008. Data on socioeconomic status, course of epilepsy, as well as direct and indirect costs were recorded using validated patient questionnaires. We enrolled 101 patients in 2003 and 151 patients in 2008. In both cohorts, 76% of the patients suffered from focal epilepsy, and the majority was on antiepileptic drug (AED) polytherapy (mean AED number: 1.7 (2003), 1.8 (2008)). We calculated epilepsy-specific costs of € 2955 in 2003 and € 3532 in 2008 per 3 months per patient. Direct medical costs were mainly due to anticonvulsants in 2003 (59.4% of total direct costs, 34.0% in 2008) and to hospitalization in 2008 (46.9% of total direct costs, 27.7% in 2003). The proportion of enzyme-inducing anticonvulsants and 'old' AEDs decreased between 2003 and 2008. Indirect costs of € 1689 and € 1847 were mainly due to early retirement (48.4%; 46.0% of total indirect costs in 2003; 2008), unemployment (26.1%; 24.2%), and days off due to seizures (25.5%; 29.8%). This study showed a shift in distribution of direct cost components with increased hospital costs as well as a cost-neutral increase in the prescription of 'newer' AEDs. The amount and distribution of indirect cost components remained unchanged.

  9. Improved drug targeting of cancer cells by utilizing actively targetable folic acid-conjugated albumin nanospheres.

    Science.gov (United States)

    Shen, Zheyu; Li, Yan; Kohama, Kazuhiro; Oneill, Brian; Bi, Jingxiu

    2011-01-01

    Folic acid-conjugated albumin nanospheres (FA-AN) have been developed to provide an actively targetable drug delivery system for improved drug targeting of cancer cells with reduced side effects. The nanospheres were prepared by conjugating folic acid onto the surface of albumin nanospheres using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDAC) as a catalyst. To test the efficacy of these nanospheres as a potential delivery platform, doxorubicin-loaded albumin nanospheres (DOX-AN) and doxorubicin-loaded FA-AN (FA-DOX-AN) were prepared by entrapping DOX (an anthracycline, antibiotic drug widely used in cancer chemotherapy that works by intercalating DNA) into AN and FA-AN nanoparticles. Cell uptake of the DOX was then measured. The results show that FA-AN was incorporated into HeLa cells (tumor cells) only after 2.0h incubation, whereas HeLa cells failed to incorporate albumin nanospheres without conjugated folic acid after 4.0h incubation. When HeLa cells were treated with the DOX-AN, FA-DOX-AN nanoparticles or free DOX, cell viability decreased with increasing culture time (i.e. cell death increases with time) over a 70h period. Cell viability was always the lowest for free DOX followed by FA-DOX-AN4 and then DOX-AN. In a second set of experiments, HeLa cells washed to remove excess DOX after an initial incubation for 2h were incubated for 70h. The corresponding cell viability was slightly higher when the cells were treated with FA-DOX-AN or free DOX whilst cells treated with DOX-AN nanoparticles remained viable. The above experiments were repeated for non-cancerous, aortic smooth muscle cells (AoSMC). As expected, cell viability of the HeLa cells (with FA receptor alpha, FRα) and AoSMC cells (without FRα) decreased rapidly with time in the presence of free DOX, but treatment with FA-DOX-AN resulted in selective killing of the tumor cells. These results indicated that FA-AN may be used as a promising actively targetable drug delivery system to improve drug

  10. UTILIZATION OF ACTIVATED ZEOLITE AS MOLECULAR SIEVE IN CHROMATOGRAPHIC COLUMN FOR SEPARATION OF COAL TAR COMPOUNDS

    Directory of Open Access Journals (Sweden)

    Dwi Retno Nurotul Wahidiyah

    2010-06-01

    Full Text Available Application of activated zeolite (ZAA as molecular sieve to separate compounds of coal tar from vaccum fractional distillation, have been done. The size of zeolite was 10-20 mesh and used as solid phase in column chromatography with length of 30 cm. The first step of the research was coal pyrolisis and the product (tar was distillated by fractional column and vaccum system at reduced pressure 44 cmHg and maximum temperature at 200 oC. The distillate from this procedure was flowed to the column chromatography of zeolite (ZAA. The compound absorbed by zeolite was eluted with varying solvents, i.e: CCl4, acetone and ethanol. Each fraction was then analyzed by gas chromatography. The results showed, zeolite have a capability to separate the compounds of tar and it tends to absorb medium hydrocarbon. The nonpolar eluent [CCl4] gives the better result in eluting tar compound than polar (ethanol or medium polar eluents (acetone.   Keywords: zeolite, coal tar, column chromatography

  11. Utilization of activated CO2-neutralized red mud for removal of arsenate from aqueous solutions.

    Science.gov (United States)

    Sahu, Ramesh Chandra; Patel, Rajkishore; Ray, Bankim Chandra

    2010-07-15

    A laboratory study was conducted to investigate the ability of activated CO(2)-neutralized red mud (ANRM) for the removal of arsenate from the aqueous solutions. The batch adsorption experiments were conducted with respect to adsorbent dose, equilibrium pH, contact time, initial arsenate concentration, kinetics, Langmuir isotherms. The mechanisms involved in adsorption of arsenate ions on ANRM were characterized by using XRD, FT-IR, UV-vis, SEM/EDX, and chemical methods. The percentage removal was found to increase gradually with decrease of pH and maximum removal was achieved at pH approximately 4. Adsorption kinetic studies revealed that the adsorption process followed pseudo-second-order kinetics and equilibrates within 24 h. FT-IR spectra of ANRM before and after adsorption reveals the binding of arsenate to the adsorbent. The adsorption data were fitted to linearly transformed Langmuir isotherm with R(2) (correlation coefficient)>0.99. Arsenate adsorbed ANRM can be regenerated using NaOH solution at pH 12.0.

  12. A Novel Colorimetric Immunoassay Utilizing the Peroxidase Mimicking Activity of Magnetic Nanoparticles

    Directory of Open Access Journals (Sweden)

    Hyun Gyu Park

    2013-05-01

    Full Text Available A simple colorimetric immunoassay system, based on the peroxidase mimicking activity of Fe3O4 magnetic nanoparticles (MNPs, has been developed to detect clinically important antigenic molecules. MNPs with ca. 10 nm in diameter were synthesized and conjugated with specific antibodies against target molecules, such as rotaviruses and breast cancer cells. Conjugation of the MNPs with antibodies (MNP-Abs enabled specific recognition of the corresponding target antigenic molecules through the generation of color signals arising from the colorimetric reaction between the selected peroxidase substrate, 3,3',5,5'-tetramethylbenzidine (TMB and H2O2. Based on the MNP-promoted colorimetric reaction, the target molecules were detected and quantified by measuring absorbance intensities corresponding to the oxidized form of TMB. Owing to the higher stabilities and economic feasibilities of MNPs as compared to horseradish peroxidase (HRP, the new colorimetric system employing MNP-Abs has the potential of serving as a potent immunoassay that should substitute for conventional HRP-based immunoassays. The strategy employed to develop the new methodology has the potential of being extended to the construction of simple diagnostic systems for a variety of biomolecules related to human cancers and infectious diseases, particularly in the realm of point-of-care applications.

  13. Utilization of biodiesel waste as a renewable resource for activated carbon. Application to environmental problems

    Energy Technology Data Exchange (ETDEWEB)

    Foo, K.Y.; Hameed, B.H. [School of Chemical Engineering, Engineering Campus, University of Science Malaysia, 14300 Nibong Tebal, Penang (Malaysia)

    2009-12-15

    Stepping into the new globalized and paradigm shifted era, a huge revolution has been undergone by the oil palm industry. From a humble source of the edible oil, today oil palm has demonstrated a wide variety of uses, almost by every part of its plant. With the price of the crude petroleum hitting record height every other day, the feasibility of palm oil and oil palm biomass as renewable substitutes for the production of biodiesel has been proposed. Lately, its development has received various criticisms, mainly hinges on the huge generation of solid residues which are currently no profitable use. In view of the aforementioned reason, this paper presents a state-of-the-art review of oil palm industry, its fundamental background studies, propagation and industrial applications. Moreover, the recent developments on the preparation of activated carbons from oil palm waste, its major challenges together with the future expectation are summarized and discussed. Conclusively, the expansion of oil palm waste in the field of adsorption science represents a potentially viable and powerful tool, leading to the superior improvement of pollution control and environmental conservation. (author)

  14. Analysis of Muscle Activity Utilizing Bench Presses in the AnyBody Simulation Modelling System

    Directory of Open Access Journals (Sweden)

    Zhongqiu Ji

    2016-01-01

    Full Text Available Using the AnyBody human modeling system with identical weights and varying grip distance (40.0 cm, 50.0 cm, and 60.0 cm, the stress distribution for the pectoralis and the muscle of upper extremity during a bench press was simulated, and the surface myoelectricity (EMG method was validated. Methods. The physical parameters driving the model of the human body were selected as weights of 35.0% (25.0 kg and grip distances. Conclusion. The validation of AnyBody software was proved as a high validity by using EMG test of four muscles’ activity compared to AnyBody software. During a bench press, the pectoralis major is the main muscle, the pectoralis major discharge increases with the height of barbell increases, and the pectoralis major discharge decreases as the short grip width increases. When the grip width equals the shoulder width, the value of pectoralis minor is lowest; when the grip width is smaller or larger than the shoulder width, the value is larger. As the short grip distance increases, the discharge of posterior deltoid muscle and triceps surface myoelectricity increases; thus, as the short grip distance increases, the deltoid muscle and triceps assist the pectoralis major during a bench press.

  15. Utilization of quantitative structure-activity relationships (QSARs) in risk assessment: Alkylphenols

    Energy Technology Data Exchange (ETDEWEB)

    Beck, B.D.; Toole, A.P.; Callahan, B.G.; Siddhanti, S.K. (Gradient Corporation, Cambridge, MA (United States))

    1991-12-01

    Alkylphenols are a class of environmentally pervasive compounds, found both in natural (e.g., crude oils) and in anthropogenic (e.g., wood tar, coal gasification waste) materials. Despite the frequent environmental occurrence of these chemicals, there is a limited toxicity database on alkylphenols. The authors have therefore developed a 'toxicity equivalence approach' for alkylphenols which is based on their ability to inhibit, in a specific manner, the enzyme cyclooxygenase. Enzyme-inhibiting ability for individual alkylphenols can be estimated based on the quantitative structure-activity relationship developed by Dewhirst (1980) and is a function of the free hydroxyl group, electron-donating ring substituents, and hydrophobic aromatic ring substituents. The authors evaluated the toxicological significance of cyclooxygenase inhibition by comparison of the inhibitory capacity of alkylphenols with the inhibitory capacity of acetylsalicylic acid, or aspirin, a compound whose low-level effects are due to cyclooxygenase inhibition. Since nearly complete absorption for alkylphenols and aspirin is predicted, based on estimates of hydrophobicity and fraction of charged molecules at gastrointestinal pHs, risks from alkylphenols can be expressed directly in terms of 'milligram aspirin equivalence,' without correction for absorption differences. They recommend this method for assessing risks of mixtures of alkylphenols, especially for those compounds with no chronic toxicity data.38 references.

  16. Utilization of Activated Carbon for the Removal of Ni Metal from Industrial Liquid Waste

    Directory of Open Access Journals (Sweden)

    *1H. Tahir

    2014-06-01

    Full Text Available Environmental pollution caused by toxic metals seems to occur globally. Metal intoxicated wastewater can be challenging to health safety. The high concentration of pollutants is required to be removed before the discharge of wastewater into open waste streams. The present study relates the monitoring of heavy metals in the industrial waste coming from Shairshah, Lyari SITE industrial area and control sites selected from Clifton beach of Karachi (Pakistan. Concentrations of selected trace metals, Cr, Fe, Hg, Na, K, Cd, Pb, Ni, Zn, Mo, Mn and Cu were estimated by using Atomic Absorption Spectrophotometer, Flame Photometer and 200 Multi parameter Ion Specific Meter under standard analytical conditions. Statistical methods of relevance were applied to check the accuracy of the system. Selective removal of Ni metal from waste water was carried out by adsorption process using activated carbon prepared from agricultural waste. The effectiveness of the adsorption process has been tested under the optimized conditions of temperature, concentration, stay time and amount of adsorbent. Adsorption isotherm models like Freundlich and Langmuir were applied to determine the feasibility of process by finding the values oftheir respective constants. The R2 values show that Langmuir model was the best fitted adsorption model. The feasibility of adsorption process was determined by RL factor. Thermodynamic parameters such as free energy (ΔG˚, enthalpy (ΔH˚ and entropy (ΔS˚ of the system were calculated. The sorption free energy (Es was also estimated. The pHpzc of adsorbent was also estimated by adopting pH drift method. The percentage removal and distribution coefficient (KD values for Ni removal were also determined. The present system represents that Ni and other metals can be effectively removed by employing adsorption method using low cost natural adsorbents.

  17. PPARd activation in human myotubes increases mitochondrial fatty acid oxidative capacity and reduces glucose utilization by a switch in substrate preference

    NARCIS (Netherlands)

    Feng, Y.; Nikolic, N.; Bakke, S.S.; Kersten, A.H.; Boekschoten, M.V.

    2014-01-01

    The role of peroxisome proliferator-activated receptor d (PPARd) activation on global gene expression and mitochondrial fuel utilization were investigated in human myotubes. Only 21 genes were up-regulated and 3 genes were down-regulated after activation by the PPARd agonist GW501516. Pathway analys

  18. Near Real-Time Nondestructive Active Inspection Technologies Utilizing Delayed γ-Rays and Neutrons for Advanced Safeguards

    Energy Technology Data Exchange (ETDEWEB)

    Hunt, Alan [Idaho State Univ., Pocatello, ID (United States). Idaho Accelerator Center, Dept. of Physics; Reedy, E. T.E. [Idaho State Univ., Pocatello, ID (United States). Dept. of Phyics, Idaho Accelerator Center; Mozin, V. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Tobin, S. J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Nuclear Nonproliferation

    2015-02-12

    In this two year project, the research team investigated how delayed γ-rays from short-lived fission fragments detected in the short interval between irradiating pulses can be exploited for advanced safeguards technologies. This program contained experimental and modeling efforts. The experimental effort measured the emitted spectra, time histories and correlations of the delayed γ-rays from aqueous solutions and solid targets containing fissionable isotopes. The modeling effort first developed and benchmarked a hybrid Monte Carlo simulation technique based on these experiments. The benchmarked simulations were then extended to other safeguards scenarios, allowing comparisons to other advanced safeguards technologies and to investigate combined techniques. Ultimately, the experiments demonstrated the possible utility of actively induced delayed γ-ray spectroscopy for fissionable material assay.

  19. A β-mannan utilization locus in Bacteroides ovatus involves a GH36 α-galactosidase active on galactomannans.

    Science.gov (United States)

    Reddy, Sumitha K; Bågenholm, Viktoria; Pudlo, Nicholas A; Bouraoui, Hanene; Koropatkin, Nicole M; Martens, Eric C; Stålbrand, Henrik

    2016-07-01

    The Bacova_02091 gene in the β-mannan utilization locus of Bacteroides ovatus encodes a family GH36 α-galactosidase (BoGal36A), transcriptionally upregulated during growth on galactomannan. Characterization of recombinant BoGal36A reveals unique properties compared to other GH36 α-galactosidases, which preferentially hydrolyse terminal α-galactose in raffinose family oligosaccharides. BoGal36A prefers hydrolysing internal galactose substitutions from intact and depolymerized galactomannan. BoGal36A efficiently releases (> 90%) galactose from guar and locust bean galactomannans, resulting in precipitation of the polysaccharides. As compared to other GH36 structures, the BoGal36A 3D model displays a loop deletion, resulting in a wider active site cleft which likely can accommodate a galactose-substituted polymannose backbone. © 2016 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

  20. Microbial network for waste activated sludge cascade utilization in an integrated system of microbial electrolysis and anaerobic fermentation

    DEFF Research Database (Denmark)

    Liu, Wenzong; He, Zhangwei; Yang, Chunxue

    2016-01-01

    and Parabacteroides, which showed a delayed contribution to the extracellular electron transport leading to a slow cascade utilization of WAS. Conclusions: Efficient pretreatment could supply more short-chain fatty acids and higher conductivities in the fermentative liquid, which facilitated mass transfer in anodic......Background: Bioelectrochemical systems have been considered a promising novel technology that shows an enhanced energy recovery, as well as generation of value-added products. A number of recent studies suggested that an enhancement of carbon conversion and biogas production can be achieved...... in an integrated system of microbial electrolysis cell (MEC) and anaerobic digestion (AD) for waste activated sludge (WAS). Microbial communities in integrated system would build a thorough energetic and metabolic interaction network regarding fermentation communities and electrode respiring communities...

  1. Utilization of actinide as cell active materials. Effective utilization of uranium as battery active material. JAERI's nuclear research promotion program, H10-034-2. Contract research

    Energy Technology Data Exchange (ETDEWEB)

    Yamana, Hajimu; Moriyama, Hirotake; Asano, Hideki [Kyoto Univ., Kumatori, Osaka (Japan). Research Reactor Institute; Shiokawa, Yoshinobu; Yamamura, Asao; Hasegawa, Kazuki; Kimura, Akihiro; Umekita, Satoshi [Tohoku Univ., Sendai (Japan). Inst. for Materials Research

    2002-03-01

    As a part of the research to explore the advantageous utilization of actinide elements as battery active materials, the concept of the uranium battery using molten salts was studied. As a result of the comparative evaluation on the redox-flow-battery and other secondary battery, U(Bi)-Cl{sub 2} battery using molten chloride was selected. As the substitute of UCl{sub 3}, LaCl{sub 3} was tested for analyzing its properties of electrochemical reduction. By Electro-motive-force measurement, the activity coefficient of some lanthanide metals in liquid bismuth was determined. By cyclic voltammetry, electrochemical properties, such as electro-deposition characteristics, reductive dissolution of La metal into liquid Bi, co-deposition of La and Bi by forming binary intermetallic compounds, were investigated. For the purpose of developing a technique to analyze the chemical status of U in molten salt, high temperature UV-Visible Spectrophotometry device was developed, and it was tested with NdCl{sub 3}. (author)

  2. Pareto utility

    NARCIS (Netherlands)

    Masako, I.; Laeven, R.J.A.; Magnus, J.R.; Muris, C.

    2013-01-01

    In searching for an appropriate utility function in the expected utility framework, we formulate four properties that we want the utility function to satisfy. We conduct a search for such a function, and we identify Pareto utility as a function satisfying all four desired properties. Pareto utility

  3. Association between oral 5-ASA adherence and health care utilization and costs among patients with active ulcerative colitis

    Directory of Open Access Journals (Sweden)

    Mitra Debanjali

    2012-09-01

    Full Text Available Abstract Background Observational cohort study to assess the association between adherence to oral 5-aminosalicylates (5-ASAs and all-cause costs and health care utilization among patients with active ulcerative colitis (UC in the United States. Methods Retrospective analysis of insurance claims from June 1997 to August 2006 in the LifeLink Database. Patient criteria: aged 18 or older with one or more claim(s between June 1997 and August 2005 for a UC diagnosis and at least one oral 5-ASA prescription on or after the first observed UC diagnosis; continuous enrollment for at least 6 months prior to and 12 months following 5-ASA initiation (index date. As a proxy for active disease, patients needed to have at least two UC-specific non-pharmacy claims, at least 30 days of 5-ASA treatment and at least one corticosteroid prescription within the 12-month post-index period. Cumulative exposure to oral 5-ASAs over the 12-month period was calculated using the medication possession ratio (MPR. Patients with an MPR of at least 0.80 were classified as adherent. All-cause medical and pharmacy resource utilization and costs were computed over the 12-month post-index period and compared between adherent and nonadherent patients. Results 1,693 UC patients met study inclusion criteria: 72% were nonadherent to 5-ASA treatment (n = 1,217 and 28% were adherent (n = 476 in the 12-month study period. Compared with nonadherent patients, adherent patients had 31% fewer hospitalizations (P = 0.0025 and 34% fewer emergency department admissions (P = 0.0016. Adherent patients had 25% more pharmacy prescriptions overall (P P P = 0.0002. After adjusting for covariates, total all-cause costs were 29% higher for nonadherent patients than for adherent patients (mean [95% confidence interval]: $13,465 [$13,094, $13,835] vs $17,339 [$17,033, $17,645]. Conclusions Approximately three-quarters of patients with active UC were not adherent with their

  4. A microfluidic chip for formation and collection of emulsion droplets utilizing active pneumatic micro-choppers and micro-switches.

    Science.gov (United States)

    Lai, Chia-Wei; Lin, Yen-Heng; Lee, Gwo-Bin

    2008-10-01

    The formation of emulsification droplets is crucial for many industrial applications. This paper reports a new microfluidic chip capable of formation and collection of micro-droplets in liquids for emulsion applications. This microfluidic chip comprising microchannels, a micro-chopper and a micro-switch was fabricated by using micro-electro-mechanical-systems (MEMS) technology. The microfluidic chip can generate uniform droplets with tunable sizes by using combination of flow-focusing and liquid-chopping techniques. The droplet size can be actively fine-tuned by controlling either the relative sheath/sample flow velocity ratios or the chopping frequency. The generated droplets can be then sorted to a specific collection area utilizing an active pneumatic micro-switch formed with three micro-valves. Experimental data showed that the olive oil and sodium-alginate (Na-alginate) droplets with diameters ranging from 3 mum to 70 mum with a variation less than 14% is successfully generated and collected. The development of this microfluidic system can be promising for emulsion, drug delivery and nano-medicine applications.

  5. ADN-1184 a monoaminergic ligand with 5-HT(6/7) receptor antagonist activity: pharmacological profile and potential therapeutic utility.

    Science.gov (United States)

    Kołaczkowski, M; Mierzejewski, P; Bieńkowski, P; Wesołowska, A; Newman-Tancredi, A

    2014-02-01

    Many dementia patients exhibit behavioural and psychological symptoms (BPSD) that include psychosis, aggressivity, depression and anxiety. Antipsychotic drugs are frequently prescribed but fail to significantly attenuate mood deficits, may interfere with cognitive function and are associated with motor and cardiac side effects, which are problematic in elderly patients. A need therefore exists for drugs that are better suited for the treatment of BPSD. We used in vitro cellular and in vivo behavioural tests to characterize ADN-1184, a novel arylsulfonamide ligand with potential utility for treatment of BPSD. ADN-1184 exhibits substantial 5-HT6 /5-HT7 /5-HT2A /D2 receptor affinity and antagonist properties in vitro. In tests of antipsychotic-like activity, it reversed MK-801-induced hyperactivity and stereotypies and inhibited conditioned avoidance response (MED = 3 mg·kg(-1) i.p.). Remarkably, ADN-1184 also reduced immobility time in the forced swim test at low doses (0.3 and 1 mg·kg(-1) i.p.; higher doses were not significantly active). Notably, up to 30 mg·kg(-1) ADN-1184 did not impair memory performance in the passive avoidance test or elicit significant catalepsy and only modestly inhibited spontaneous locomotor activity (MED = 30 mg·kg(-1) i.p.). ADN-1184 combines antipsychotic-like with antidepressant-like properties without interfering with memory function or locomotion. This profile is better than that of commonly used atypical antipsychotics tested under the same conditions and suggests that it is feasible to identify drugs that improve BPSD, without exacerbating cognitive deficit or movement impairment, which are of particular concern in patients with dementia. © 2013 The British Pharmacological Society.

  6. ADN-1184 a monoaminergic ligand with 5-HT6/7 receptor antagonist activity: pharmacological profile and potential therapeutic utility

    Science.gov (United States)

    Kołaczkowski, M; Mierzejewski, P; Bieńkowski, P; Wesołowska, A; Newman-Tancredi, A

    2014-01-01

    Background and Purpose Many dementia patients exhibit behavioural and psychological symptoms (BPSD) that include psychosis, aggressivity, depression and anxiety. Antipsychotic drugs are frequently prescribed but fail to significantly attenuate mood deficits, may interfere with cognitive function and are associated with motor and cardiac side effects, which are problematic in elderly patients. A need therefore exists for drugs that are better suited for the treatment of BPSD. Experimental Approach We used in vitro cellular and in vivo behavioural tests to characterize ADN-1184, a novel arylsulfonamide ligand with potential utility for treatment of BPSD. Key Results ADN-1184 exhibits substantial 5-HT6/5-HT7/5-HT2A/D2 receptor affinity and antagonist properties in vitro. In tests of antipsychotic-like activity, it reversed MK-801-induced hyperactivity and stereotypies and inhibited conditioned avoidance response (MED = 3 mg·kg−1 i.p.). Remarkably, ADN-1184 also reduced immobility time in the forced swim test at low doses (0.3 and 1 mg·kg−1 i.p.; higher doses were not significantly active). Notably, up to 30 mg·kg−1 ADN-1184 did not impair memory performance in the passive avoidance test or elicit significant catalepsy and only modestly inhibited spontaneous locomotor activity (MED = 30 mg·kg−1 i.p.). Conclusions and Implications ADN-1184 combines antipsychotic-like with antidepressant-like properties without interfering with memory function or locomotion. This profile is better than that of commonly used atypical antipsychotics tested under the same conditions and suggests that it is feasible to identify drugs that improve BPSD, without exacerbating cognitive deficit or movement impairment, which are of particular concern in patients with dementia. PMID:24199650

  7. High-Performance Harmonic Isolation and Load Voltage Regulation of the Three-Phase Series Active Filter Utilizing the Waveform Reconstruction Method

    DEFF Research Database (Denmark)

    Senturk, Osman Selcuk; Hava, Ahmet M.

    2009-01-01

    . The SAF-compensated system utilizing WRM provides highperformance load harmonic voltage isolation and load voltage regulation at steady-state and during transients compared to the system utilizing the synchronous reference-frame-based signal decomposition. In addition, reducing the line current sampling......This paper develops a waveform reconstruction method (WRM) for high accuracy and bandwidth signal decomposition of voltage-harmonic-type three-phase diode rectifier load voltage into its harmonic and fundamental components, which are utilized in the series active filter (SAF) control algorithms...

  8. Demonstration of Active Power Controls by Utility-Scale PV Power Plant in an Island Grid: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Gevorgian, Vahan; O' Neill, Barbara

    2017-02-01

    The National Renewable Energy Laboratory (NREL), AES, and the Puerto Rico Electric Power Authority conducted a demonstration project on a utility-scale photovoltaic (PV) plant to test the viability of providing important ancillary services from this facility. As solar generation increases globally, there is a need for innovation and increased operational flexibility. A typical PV power plant consists of multiple power electronic inverters and can contribute to grid stability and reliability through sophisticated 'grid-friendly' controls. In this way, it may mitigate the impact of its variability on the grid and contribute to important system requirements more like traditional generators. In 2015, testing was completed on a 20-MW AES plant in Puerto Rico, and a large amount of test data was produced and analyzed that demonstrates the ability of PV power plants to provide various types of new grid-friendly controls. This data showed how active power controls can leverage PV's value from being simply an intermittent energy resource to providing additional ancillary services for an isolated island grid. Specifically, the tests conducted included PV plant participation in automatic generation control, provision of droop response, and fast frequency response.

  9. Effect of plate preparation on active-material utilization and cycleability of positive plates in automotive lead/acid batteries

    Science.gov (United States)

    Ozgun, H.; Lam, L. T.; Rand, D. A. J.; Bhargava, S. K.

    The power demands from automotive lead/acid batteries are rising steadily with the increasing number of electronic accessories that are being fitted to modern vehicles. In order to meet new levels of performance, automotive batteries have been redesigned to use low-ohmic microporous separators, as well as thinner plates (to increase the number of plates per cell) that are made with a low paste density. This approach, however, has led to a separate problem, namely, an appreciable reduction in battery service life. To redress this situation, a research programme has been implemented in our laboratories to examine, in detail, the effect of plate preparation on the active-material utilization and cycleability of automotive positive plates with grids made from low-antimony alloy. The cycleability is evaluated in terms of repetitive reserve-capacity. The results suggest that a paste formula with a combination of high density and low acid-to-oxide ratio is the most appropriate technology for the production of the thin positive plates that are required in advanced designs of automotive batteries.

  10. Web-based educational activities developed by the Society for Neuroscience in Anesthesiology and Critical Care (SNACC): the experience of process, utilization, and expert evaluation.

    Science.gov (United States)

    Sharma, Deepak; Bilotta, Federico; Moore, Laurel E; Bebawy, John F; Flexman, Alana M; Rochlen, Lauryn; Gorji, Reza; Avitsian, Rafi

    2014-01-01

    Web-based delivery of educational material by scientific societies appears to have increased recently. However, the utilization of such efforts by the members of professional societies is unknown. We report the experience with delivery of educational resources on the Web site of the Society for Neuroscience in Anesthesiology and Critical Care (SNACC), and utilization of those resources by members. Three web-based educational initiatives were developed over 1 year to be disseminated through the SNACC Web site (http://www.snacc.org) for society members: (1) The SNACC Bibliography; (2) "Chat with the Author"; and (3) Clinical Case Discussions. Content experts and authors of important new research publications were invited to contribute. Member utilization data were abstracted with the help of the webmaster. For the bibliography, there were 1175 page requests during the 6-month period after its launch by 122/664 (19%) distinct SNACC members. The bibliography was utilized by 107/553 (19%) of the active members and 15/91 (16.5%) of the trainee members. The "Chats with the Authors" were viewed by 56 (9%) members and the Clinical Case Discussions by 51 (8%) members. Educational resources can be developed in a timely manner utilizing member contributions without additional financial implications. However, the member utilization of these resources was lower than expected. These are first estimates of utilization of web-based educational resources by members of a scientific society. Further evaluation of such utilization by members of other societies as well as measures of the effectiveness and impact of such activities is needed.

  11. Enhanced hydrogen production from waste activated sludge by cascade utilization of organic matter in microbial electrolysis cells.

    Science.gov (United States)

    Lu, Lu; Xing, Defeng; Liu, Bingfeng; Ren, Nanqi

    2012-03-15

    Fermentative hydrogen production from waste activated sludge (WAS) has low H2 yield because WAS contains limited amounts of carbohydrate suitable for use by hydrogen-producing bacteria. Here, augmentation of hydrogen production from WAS by microbial electrolysis cells (MECs) was implemented. H2 yields of 3.89±0.39 mg-H2/g-DS (5.67±0.61 mg-H2/g-VSS) from raw WAS and 6.78±0.94 mg-H2/g-DS (15.08±1.41 mg-H2/g-VSS) from alkaline-pretreated WAS were obtained in the two-chamber MECs (TMECs). This was several times higher than yields obtained previously by fermentation. Single-chamber MECs (SMECs) with low internal resistance showed a H2 production rate that 13 times that of TMECs with similar H2 yield when alkaline-pretreated WAS was used. However, methanogenesis was detected after several batch cycles. A yield balance calculation revealed that carbohydrates were not the only substrates for electrohydrogenesis. Protein and its acidification products, such as volatile fatty acids are also responsible for a portion of H2 generation in MEC. Characterization of WAS in TMECs by three-dimensional excitation-emission matrix (EEM) fluorescence spectroscopy with parallel factor analysis indicated that electrohydrogenesis reacted on the extracellular polymeric substances and intracellular substances of WAS. Cascade utilization of organic matter in MECs increased hydrogen production from WAS. MECs showed high hydrogen yield from WAS, fewer H2 sinks, and insensitivity to temperature. Optimizing MEC configurations and operation conditions and improving the pretreatment processes of WAS are necessary before practical application can take place on a large scale.

  12. An ortholog of farA of Aspergillus nidulans is implicated in the transcriptional activation of genes involved in fatty acid utilization in the yeast Yarrowia lipolytica

    Energy Technology Data Exchange (ETDEWEB)

    Poopanitpan, Napapol; Kobayashi, Satoshi; Fukuda, Ryouichi; Horiuchi, Hiroyuki [Department of Biotechnology, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657 (Japan); Ohta, Akinori, E-mail: aaohta@mail.ecc.u-tokyo.ac.jp [Department of Biotechnology, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657 (Japan)

    2010-11-26

    Research highlights: {yields} POR1 is a Yarrowia lipolytica ortholog of farA involved in fatty acid response in A. nidulans. {yields} Deletion of POR1 caused growth defects on fatty acids. {yields} {Delta}por1 strain exhibited defects in the induction of genes involved in fatty acid utilization. -- Abstract: The yeast Yarrowia lipolytica effectively utilizes hydrophobic substrates such as fatty acids and n-alkanes. To identify a gene(s) regulating fatty acid utilization in Y. lipolytica, we first studied homologous genes to OAF1 and PIP2 of Saccharomyces cerevisiae, but their disruption did not change growth on oleic acid at all. We next characterized a Y. lipolytica gene, POR1 (primary oleate regulator 1), an ortholog of farA encoding a transcriptional activator that regulates fatty acid utilization in Aspergillus nidulans. The deletion mutant of POR1 was defective in the growth on various fatty acids, but not on glucose, glycerol, or n-hexadecane. It exhibited slight defect on n-decane. The transcriptional induction of genes involved in {beta}-oxidation and peroxisome proliferation by oleate was distinctly diminished in the {Delta}por1 strains. These data suggest that POR1 encodes a transcriptional activator widely regulating fatty acid metabolism in Y. lipolytica.

  13. Burr Utility

    NARCIS (Netherlands)

    Ikefuji, M.; Laeven, R.J.A.; Magnus, J.R.; Muris, C.H.M.

    2010-01-01

    This note proposes the Burr utility function. Burr utility is a flexible two-parameter family that behaves approximately power-like (CRRA) remote from the origin, while exhibiting exponential-like (CARA) features near the origin. It thus avoids the extreme behavior of the power family near the origi

  14. Estimating Utility

    DEFF Research Database (Denmark)

    Arndt, Channing; Simler, Kenneth R.

    2010-01-01

    an information-theoretic approach to estimating cost-of-basic-needs (CBN) poverty lines that are utility consistent. Applications to date illustrate that utility-consistent poverty measurements derived from the proposed approach and those derived from current CBN best practices often differ substantially......, with the current approach tending to systematically overestimate (underestimate) poverty in urban (rural) zones....

  15. Promotion of HANARO Utilization for Year 2006

    Energy Technology Data Exchange (ETDEWEB)

    Sohn, J. M.; Kim, H. R.; Jun, B. J. (and others)

    2007-05-15

    To activate the HANARO utilization by expanding HANARO utilization fields, recruiting and training new users. In order to promote the HANARO utilization, the following activities have been performed. The neutron usage fee in HANARO. Achievements of HANARO utilization. Project for Activation of the Research using HANARO. HANARO Symposium. Survey of the HANARO User Satisfaction Index. Operation and Management of HANARO Server. Management of HANARO related committees. Training of HANARO users. Related activities of HANARO publicity. The related activities to activate HANARO utilization have been carried out successfully. This report summarized the detailed activities to activate the HANARO utilization. They will be useful for expanding HANARO utilization in the near future.

  16. ECUT: Energy Conversion and Utilization Technologies program. Industry, university and research interest in the US Department of Energy ECUT biocatalysis research activity

    Science.gov (United States)

    Wilcox, R. E.

    1983-01-01

    The results of a Research Opportunity Notice (RON) disseminated by the Jet Propulsion Laboratory for the U.S. Department of Energy Conversion and Utilization Technologies (ECUT) Program's Biocatalysis Research Activity are presented. The RON was issued in late April of 1983 and solicited expressions of interest from petrochemical and chemical companies, bioengineering firms, biochemical engineering consultants, private research laboratories, and universities for participating in a federal research program to investigate potential applications of biotechnology in producing chemicals. The RON results indicate that broad interest exists within the nation's industry, universities, and research institutes for the Activity and its planned research and development program.

  17. PTS regulation domain-containing transcriptional activator CelR and sigma factor σ(54) control cellobiose utilization in Clostridium acetobutylicum.

    Science.gov (United States)

    Nie, Xiaoqun; Yang, Bin; Zhang, Lei; Gu, Yang; Yang, Sheng; Jiang, Weihong; Yang, Chen

    2016-04-01

    The phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) regulation domain (PRD)-containing enhancer binding proteins (EBPs) are an important class of σ(54) -interacting transcriptional activators. Although PRD-containing EBPs are present in many Firmicutes, most of their regulatory functions remain unclear. In this study, the transcriptional regulons of about 50 PRD-containing EBPs in diverse Firmicutes species are reconstructed by using a comparative genomic approach, which contain the genes associated with utilization of β-glucosides, fructose/levan, mannose/glucose, pentitols, and glucosamine/fructosamine. We then present experimental evidence that the cel operon involved in cellobiose utilization is directly regulated by CelR and σ(54) (SigL) in Clostridium acetobutylicum. The predicted three CelR-binding sites and σ(54) promoter elements upstream of the cel operon are verified by in vitro binding assays. We show that CelR has an ATPase activity, which is strongly stimulated by the presence of DNA containing the CelR-binding sites. Moreover, mutations in any one of the three CelR-binding sites significantly decreased the cel promoter activity probably due to the need for all three DNA sites for maximal ATPase activity of CelR. It is suggested that CelR is regulated by PTS-mediated phosphorylation at His-551 and His-829, which exerts a positive effect and an inhibitory effect, respectively, on the CelR activity. © 2015 John Wiley & Sons Ltd.

  18. Utilization of zinc chloride for surface modification of activated carbon derived from Jatropha curcas L. for absorbent material.

    Science.gov (United States)

    Pratumpong, P; Toommee, S

    2016-12-01

    The objective of this research is to produce the low-cost activated carbon from Jatropha curcas L. by chemical activation using zinc chloride ZnCl2. The effects of the impregnation ratio on the surface and chemical properties of activated carbon were investigated. The impregnation ratio was selected at the range of 1:1-10:1 for investigation. The optimum conditions resulted in an activated carbon with a carbon content of 80% wt, while the specific surface area evaluated using nitrogen adsorption isotherm corresponds to 600 m(2)/g.

  19. The Acyl-CoA synthetases encoded within FAA1 and FAA4 in Saccharomyces cerevisiae function as components of the fatty acid transport system linking import, activation, and intracellular Utilization

    DEFF Research Database (Denmark)

    Færgeman, Nils J.; Black, P N; Zhao, X D

    2001-01-01

    Exogenous long-chain fatty acids are activated to coenzyme A derivatives prior to metabolic utilization. In the yeast Saccharomyces cerevisiae, the activation of these compounds prior to metabolic utilization proceeds through the fatty acyl-CoA synthetases Faa1p and Faa4p. Faa1p or Faa4p are esse...

  20. Utility of Self-Made Crossword Puzzles as an Active Learning Method to Study Biochemistry in Undergraduate Education

    Science.gov (United States)

    Coticone, Sulekha Rao

    2013-01-01

    To incorporate an active learning component in a one-semester biochemistry course, students were asked to create crossword puzzles using key concepts. Student observations on the use of self-made crossword puzzles as an active-learning instructional tool were collected using a 5-point Likert survey at the end of the semester. A majority of the…

  1. Implementing Child-focused Activity Meter Utilization into the Elementary School Classroom Setting Using a Collaborative Community-based Approach.

    Science.gov (United States)

    Lynch, B A; Jones, A; Biggs, B K; Kaufman, T; Cristiani, V; Kumar, S; Quigg, S; Maxson, J; Swenson, L; Jacobson, N

    2015-12-01

    The prevalence of pediatric obesity has increased over the past 3 decades and is a pressing public health program. New technology advancements that can encourage more physical in children are needed. The Zamzee program is an activity meter linked to a motivational website designed for children 8-14 years of age. The objective of the study was to use a collaborative approach between a medical center, the private sector and local school staff to assess the feasibility of using the Zamzee Program in the school-based setting to improve physical activity levels in children. This was a pilot 8-week observational study offered to all children in one fifth grade classroom. Body mass index (BMI), the amount of physical activity by 3-day recall survey, and satisfaction with usability of the Zamzee Program were measured pre- and post-study. Out of 11 children who enrolled in the study, 7 completed all study activities. In those who completed the study, the median (interquartile range) total activity time by survey increased by 17 (1042) minutes and the BMI percentile change was 0 (8). Both children and their caregivers found the Zamzee Activity Meter (6/7) and website (6/7) "very easy" or "easy" to use. The Zamzee Program was found to be usable but did not significantly improve physical activity levels or BMI. Collaborative obesity intervention projects involving medical centers, the private sector and local schools are feasible but the effectiveness needs to be evaluated in larger-scale studies.

  2. Utilizing Behavioral Economics to Understand Adherence to Physical Activity Guidelines Among a Low-Income Urban Community.

    Science.gov (United States)

    Shuval, Kerem; Si, Xia; Nguyen, Binh; Leonard, Tammy

    2015-07-01

    Behavioral economics studies have found that individuals with more patient time preferences (ie, greater willingness to forgo current costs for future benefits) are more likely to save money. Although research has observed significant relationships between time preferences and health-promoting behaviors, scant evidence exists with physical activity as an outcome. We examined the association between monetary saving behaviors and physical activity among adults of low-income who reside in an urban community. Specifically, we assessed the relationship between saving behaviors (checking/saving account, monthly savings, and planning family finances), and future orientation to physical activity as a dichotomous (meeting guidelines) and continuous (total and domain specific) endpoint. In multivariable regression, being future-oriented and having a checking/saving account were related to a 1.3 and 2.1 times higher (respectively) likelihood of meeting physical activity guidelines (P < .05). When examining physical activity continuously, all measures were significantly related to leisure-time activity (P < .05). Our study findings establish a relationship between future time preferences and increased levels of physical activity among low-income adults. Future research should prospectively explore the efficacy of various schemes that help individuals overcome impatient time preferences to determine a causal relationship.

  3. Analyzing salvia divinorum and its active ingredient salvinorin a utilizing thin layer chromatography and gas chromatography/mass spectrometry.

    Science.gov (United States)

    Jermain, John D; Evans, Hiram K

    2009-05-01

    In recent years, Salvia divinorum has become a major focus by state legislatures throughout the United States looking to prohibit the sale of the psychoactive plant. After researching testing procedures presented in the literature and those employed by crime laboratories throughout the country, it was decided that thin layer chromatography (TLC) and gas chromatography/mass spectrometry (GC/MS) were the methods to use to analyze plant material for salvinorin A. With TLC, salvinorin A was detected from extracted plant material and was easily distinguishable from 13 other Salvia species as well as Cannabis sativa L. (marijuana). When using GC/MS, salvinorin A was best extracted from plant material with chloroform at ambient temperature when using a nonpolar solvent and acetone at ambient temperature when using a polar solvent. By utilizing these techniques, criminalists are now able to confirm the presence of salvinorin A in a submitted plant material suspected to be Salvia divinorum.

  4. Perception and possible utilization of moonlight intensity for reproductive activities in a lunar-synchronized spawner, the golden rabbitfish.

    Science.gov (United States)

    Takemura, Akihiro; Susilo, Endang Sri; Rahman, M D Saydur; Morita, Masaya

    2004-10-01

    Rabbitfishes are known to spawn synchronously around the species-specific lunar phase. It is considered that they perceive and utilize cues from the moon in order to be synchronized gonadal development and spawning with the lunar cycle. Using the golden rabbitfish, Siganus guttatus, which spawns synchronously around the first quarter moon during the reproductive season, we measured the fluctuation of melatonin levels and examined the response of the fish to moonlight intensity. Daily fluctuation of melatonin concentration in the blood of golden rabbitfish showed low levels during daytime and high levels during night-time, suggesting that melatonin functions in the perception and utilization of photoperiod. Plasma melatonin concentration at the new moon was higher than that at the full moon. When the fish were exposed to moonlight at midnight of the both moon phases, the melatonin concentrations decreased to the control levels. These results show that the fish possibly perceive moonlight intensity and plasma melatonin fluctuates according to 'lightness' at a point of night. At the first spawning period (experiment was started one month before the spawning), the fish reared under natural conditions spawned at the expected spawning dates, whereas the fish reared under the constant darkness and lightness of night did not spawn. At the second spawning period (experiment was started 2 weeks before the spawning), the fish reared under the conditions of natural and constant darkness of night spawned but not that of constant lightness of night. It is possible that night conditions are related to synchronous gonadal development and spawning in the golden rabbitfish.

  5. Utility and safety of temporary pacing using active fixation leads and externalized re-usable permanent pacemakers after lead extraction

    National Research Council Canada - National Science Library

    Kawata, Hiro; Pretorius, Victor; Phan, Huy; Mulpuru, Siva; Gadiyaram, Varuna; Patel, Jigar; Steltzner, Dawna; Krummen, David; Feld, Gregory; Birgersdotter-Green, Ulrika

    2013-01-01

    .... The use of an externalized permanent active-fixation pacemaker lead connected to a permanent pacemaker generator for temporary pacing may be beneficial because of improved lead stability, and greater...

  6. Multiattribute Utility Theory without Expected Utility Foundations

    NARCIS (Netherlands)

    A.M. Stiggelbout; P.P. Wakker

    1995-01-01

    Methods for determining the form of utilities are needed for the implementation of utility theory in specific decisions. An important step forward was achieved when utility theorists characterized useful parametric families of utilities, and simplifying decompositions of multiattribute utilities. Th

  7. Utilization of activated carbon produced from fruit juice industry solid waste for the adsorption of Yellow 18 from aqueous solutions.

    Science.gov (United States)

    Angin, Dilek

    2014-09-01

    The use of activated carbon obtained from sour cherry (Prunus cerasus L.) stones for the removal of a basic textile dye, which is Yellow 18, from aqueous solutions at different contact times, pH values and solution temperatures was investigated. The surface area and micropore volume of chemically modified activated carbon were 1704 m(2) g(-1) and 0.984 cm(3) g(-1), respectively. The experimental data indicated that the adsorption isotherms were well described by the Langmuir equilibrium isotherm equation and the calculated adsorption capacity was 75.76 mg g(-1) at 318 K. The adsorption kinetic of Yellow 18 obeys the pseudo-second-order kinetic model. The thermodynamic parameters were calculated to estimate the nature of adsorption. The activation energy of the system was calculated as 0.71-2.36 kJ/mol. According to these results, prepared activated carbon could be used as a low-cost adsorbent to compare with the commercial activated carbon for the removal of Yellow 18 from wastewater.

  8. A Case of Thrombotic Thrombocytopenia Purpura Associated with Systemic Lupus Erythematosus: Diagnostic Utility of ADAMTS-13 Activity

    Directory of Open Access Journals (Sweden)

    Risa Yamada

    2011-01-01

    Full Text Available Thrombotic thrombocytopenia purpura (TTP caused by a deficiency in ADAMTS-13 activity is considered to involve a subset of thrombotic microangiopathy (TMA. Although concept of TTP is included under the umbrella of TMA, discrimination of TTP from TMA is occasionally difficult in an autoimmune disorder. Herein, we report a case with TTP associated with systemic lupus erythematosus (SLE. In this case, it was difficult to discriminate TTP from TMA and the measurement of ADAMTS-13 activity was useful for obtaining an accurate diagnosis. SLE patients having thrombocytopenia in complication with anemia should be considered a monitoring of ADAMTS-13 activity even though the patients lacked symptoms of TTP related to the microvascular coagulation.

  9. Measurements of the Backstreaming Proton IONS in the Self-Magnetic Pinch (SMP) Diode Utilizing Copper Activation Technique

    Science.gov (United States)

    Mazarakis, Michael; Cuneo, Michael; Fournier, Sean; Johnston, Mark; Kiefer, Mark; Leckbee, Joshua; Simpson, Sean; Renk, Timothy; Webb, Timothy; Bennett, Nichelle

    2016-10-01

    The results presented here were obtained with an SMP diode mounted at the front high voltage end of the 8-10-MV RITS Self-Magnetically Insulated Transmission Line (MITL) voltage adder. Our experiments had two objectives: first, to measure the contribution of the back-streaming proton currents emitted from the anode target, and second, to evaluate the energy of those ions and hence the actual Anode-Cathode (A-K) gap voltage. The accelerating voltage quoted in the literature is estimated utilizing para-potential flow theories. Thus, it is interesting to have another independent measurement of the A-K voltage. We have measured the back-streaming protons emitted from the anode and propagating through a hollow cathode tip for various diode configurations and different techniques of target cleaning treatment, namely, heating at very high temperatures with DC and pulsed current, with RF plasma cleaning, and with both plasma cleaning and heating. We have also evaluated the A-K gap voltage by energy filtering techniques. Sandia is operated by Sandia Corporation, a subsidiary of Lockheed Martin Company, for the US DOE NNSA under Contract No. DE-AC04-94AL85000.

  10. Inserting CO2 into Aryl C-H Bonds of Metal-Organic Frameworks: CO2 Utilization for Direct Heterogeneous C-H Activation.

    Science.gov (United States)

    Gao, Wen-Yang; Wu, Haifan; Leng, Kunyue; Sun, Yinyong; Ma, Shengqian

    2016-04-25

    Described for the first time is that carbon dioxide (CO2 ) can be successfully inserted into aryl C-H bonds of the backbone of a metal-organic framework (MOF) to generate free carboxylate groups, which serve as Brønsted acid sites for efficiently catalyzing the methanolysis of epoxides. The work delineates the very first example of utilizing CO2 for heterogeneous C-H activation and carboxylation reactions on MOFs, and opens a new avenue for CO2 chemical transformations under mild reaction conditions.

  11. Ferulic acid-coupled chitosan: thermal stability and utilization as an antioxidant for biodegradable active packaging film.

    Science.gov (United States)

    Woranuch, Sarekha; Yoksan, Rangrong; Akashi, Mitsuru

    2015-01-22

    The aim of the present research was to study the thermal stability of ferulic acid after coupling onto chitosan, and the possibility of using ferulic acid-coupled chitosan (FA-CTS) as an antioxidant for biodegradable active packaging film. FA-CTS was incorporated into biodegradable film via a two-step process, i.e. compounding extrusion at temperatures up to 150°C followed by blown film extrusion at temperatures up to 175°C. Although incorporation of FA-CTS with a content of 0.02-0.16% (w/w) caused decreased water vapor barrier property and reduced extensibility, the biodegradable films possessed improved oxygen barrier property and antioxidant activity. Radical scavenging activity and reducing power of film containing FA-CTS were higher than those of film containing naked ferulic acid, by about 254% and 94%, respectively. Tensile strength and rigidity of the films were not significantly affected by the addition of FA-CTS with a content of 0.02-0.08% (w/w). The above results suggested that FA-CTS could potentially be used as an antioxidant for active packaging film.

  12. Efficient utilization of Eucheuma denticulatum hydrolysates using an activated carbon adsorption process for ethanol production in a 5-L fermentor.

    Science.gov (United States)

    Ra, Chae Hun; Kim, Min Ji; Jeong, Gwi-Taek; Kim, Sung-Koo

    2017-03-01

    A total monosaccharide concentration of 37.8 g/L and 85.9% conversion from total fermentable monosaccharides of 44.0 g/L from 110 g dw/L Eucheuma denticulatum slurry were obtained by thermal acid hydrolysis and enzymatic saccharification. Subsequent adsorption treatment to remove 5-hydroxymethylfurfural (5-HMF) using 5% activated carbon and an adsorption time of 10 min were used to prevent a prolonged lag phase, reduced cell growth, and low ethanol production. The equilibrium adsorption capacity (q e) of HMF (58.183 mg/g) showed high affinity to activated carbon comparing to those of galactose (2.466 mg/g) and glucose (2.474 mg/g). The efficiency of cell growth and ethanol production with activated carbon treatment was higher than that without activated carbon treatment. Fermentation using S. stipitis KCTC7228 produced a cell concentration of 3.58 g dw/L with Y X/S of 0.107, and an ethanol concentration of 15.8 g/L with Y P/S of 0.48 in 96 h.

  13. Achromobactor denitrificans SP1 produces pharmaceutically active 25C prodigiosin upon utilizing hazardous di(2-ethylhexyl)phthalate

    Science.gov (United States)

    Achromobacter denitrificans SP1 isolated from soil sludge heavily contaminated with plastic waste produced a novel pharmaceutically-active 25C prodigiosin analog during growth in a simple mineral salt medium supplemented with hazardous di(2-ethylhexyl)phthalate (DEHP) blended PVC plastics (in situ) ...

  14. Utilizing Talking Circles as a Means of Gathering American Indian Stories for Developing a Nutrition and Physical Activity Curriculum

    Science.gov (United States)

    Brandenburger, Shelly J.; Wells, Karlys; Stluka, Suzanne

    2017-01-01

    This qualitative study used a focus group approach (talking circles) to elicit tribal elder insight on important concepts for the purpose of creating a curriculum to teach tribal youth in South Dakota about nutrition and physical activity in culturally appropriate ways. The focus groups were part of a larger project that is exploring mechanisms…

  15. One-Two Punch: Utilizing Teacher Research Experiences and Related Classroom Activities to Increase Student Interest in STEM

    Science.gov (United States)

    Wold-Brennon, R.; Cooper, S. K.

    2014-12-01

    Through collaborations between scientists and educators, the Consortium for Ocean Leadership developed a series of marine geosciences classroom activities and lesson plans -- including the Adopt-a-Microbe project, a collection of hands-on science lessons that use the sub-seafloor microbiology topics to provide engaging pathways for K-12 students to learn about the world around them. The goal of these activities has been to introduce youth to deep ocean exploration, inspire interest in microbial oceanography, and foster higher education goals and career paths in related sciences for our youth. From the beginning, these lessons were developed in close working relationships between scientists and educators, and the lessons geared towards middle school have been recently piloted with the intent to maximize sustained student interest in STEM topics. While teaching these units, educators used surveys, polls, group discussions, and interviews to shed light on correlations between student interest in STEM and their close proximity to exemplary and enthusiastic educators and student leaders who are active in STEM activities such as research projects and expeditions. Educators continue to use Adopt-a-Microbe and related expedition science-based lessons to explore the broader impacts of their professional development in the Geosciences on their students' professed interest in STEM.

  16. SV40 utilizes ATM kinase activity to prevent non-homologous end joining of broken viral DNA replication products.

    Directory of Open Access Journals (Sweden)

    Gregory A Sowd

    2014-12-01

    Full Text Available Simian virus 40 (SV40 and cellular DNA replication rely on host ATM and ATR DNA damage signaling kinases to facilitate DNA repair and elicit cell cycle arrest following DNA damage. During SV40 DNA replication, ATM kinase activity prevents concatemerization of the viral genome whereas ATR activity prevents accumulation of aberrant genomes resulting from breakage of a moving replication fork as it converges with a stalled fork. However, the repair pathways that ATM and ATR orchestrate to prevent these aberrant SV40 DNA replication products are unclear. Using two-dimensional gel electrophoresis and Southern blotting, we show that ATR kinase activity, but not DNA-PK(cs kinase activity, facilitates some aspects of double strand break (DSB repair when ATM is inhibited during SV40 infection. To clarify which repair factors associate with viral DNA replication centers, we examined the localization of DSB repair proteins in response to SV40 infection. Under normal conditions, viral replication centers exclusively associate with homology-directed repair (HDR and do not colocalize with non-homologous end joining (NHEJ factors. Following ATM inhibition, but not ATR inhibition, activated DNA-PK(cs and KU70/80 accumulate at the viral replication centers while CtIP and BLM, proteins that initiate 5' to 3' end resection during HDR, become undetectable. Similar to what has been observed during cellular DSB repair in S phase, these data suggest that ATM kinase influences DSB repair pathway choice by preventing the recruitment of NHEJ factors to replicating viral DNA. These data may explain how ATM prevents concatemerization of the viral genome and promotes viral propagation. We suggest that inhibitors of DNA damage signaling and DNA repair could be used during infection to disrupt productive viral DNA replication.

  17. SV40 utilizes ATM kinase activity to prevent non-homologous end joining of broken viral DNA replication products.

    Science.gov (United States)

    Sowd, Gregory A; Mody, Dviti; Eggold, Joshua; Cortez, David; Friedman, Katherine L; Fanning, Ellen

    2014-12-01

    Simian virus 40 (SV40) and cellular DNA replication rely on host ATM and ATR DNA damage signaling kinases to facilitate DNA repair and elicit cell cycle arrest following DNA damage. During SV40 DNA replication, ATM kinase activity prevents concatemerization of the viral genome whereas ATR activity prevents accumulation of aberrant genomes resulting from breakage of a moving replication fork as it converges with a stalled fork. However, the repair pathways that ATM and ATR orchestrate to prevent these aberrant SV40 DNA replication products are unclear. Using two-dimensional gel electrophoresis and Southern blotting, we show that ATR kinase activity, but not DNA-PK(cs) kinase activity, facilitates some aspects of double strand break (DSB) repair when ATM is inhibited during SV40 infection. To clarify which repair factors associate with viral DNA replication centers, we examined the localization of DSB repair proteins in response to SV40 infection. Under normal conditions, viral replication centers exclusively associate with homology-directed repair (HDR) and do not colocalize with non-homologous end joining (NHEJ) factors. Following ATM inhibition, but not ATR inhibition, activated DNA-PK(cs) and KU70/80 accumulate at the viral replication centers while CtIP and BLM, proteins that initiate 5' to 3' end resection during HDR, become undetectable. Similar to what has been observed during cellular DSB repair in S phase, these data suggest that ATM kinase influences DSB repair pathway choice by preventing the recruitment of NHEJ factors to replicating viral DNA. These data may explain how ATM prevents concatemerization of the viral genome and promotes viral propagation. We suggest that inhibitors of DNA damage signaling and DNA repair could be used during infection to disrupt productive viral DNA replication.

  18. Daily Activity Patterns and Perch Height Utilization in Pre-Breeding Season by Forest Calotes, Calotes rouxii (Sauria: Agamidae in the Sacred Grove of the Northern Western Ghats

    Directory of Open Access Journals (Sweden)

    Sameer Bajru

    2016-01-01

    Full Text Available Although, the Forest Calotes Calotes rouxii is the most common and endemic species of lizard inhabiting the Western Ghats, information on its ecology is remain scarce. In order to better understanding of life history of C. rouxii, we investigated its pre breeding activity patterns and microhabitat utilization in a small sacred grove (~0.65 ha of the northern Western Ghats. Calotes rouxii showed a unimodal activity pattern, peak activity period was observed at late morning (11.00-12.30 h and afternoon (13.00-15.45 h. The activity patterns of lizards involved basking and resting at early morning period. Once they attained optimum body temperature at peak period activities such as moving, social displays and foraging were performed. In late afternoon all activities were decreased and they retreat to their refuge sites. Sex specific microhabitat segregation was detected; males occupied higher perches than females. The males encounter during study period were positively correlated with temperature while negatively correlated with humidity, however females encountered were not correlated with humidity and temperature.

  19. Earthworm extracts utilized in the green synthesis of gold nanoparticles capable of reinforcing the anticoagulant activities of heparin

    Science.gov (United States)

    Kim, Hee Kyeong; Choi, Myung-Jin; Cha, Song-Hyun; Koo, Yean Kyoung; Jun, Sang Hui; Cho, Seonho; Park, Youmie

    2013-12-01

    Gold nanoparticles were obtained using a green synthesis approach with aqueous earthworm extracts without any additional reducing or capping agents. The gold nanoparticles were characterized using UV-visible spectrophotometry, high-resolution transmission electron microscopy, atomic force microscopy, field emission scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and inductively coupled plasma mass spectrometry. The anticoagulant activity of the gold nanoparticles was assessed using the activated partial thromboplastin time and was mildly enhanced by combining the gold nanoparticles with heparin. In addition to the generation of spherical nanoparticles with an average diameter of 6.13 ± 2.13 nm, cubic and block-shaped nanoparticles with an average aspect ratio, defined as the length divided by width, of 1.47 were also observed.

  20. A Randomized Controlled Trial of In-Home Tele-behavioral Health Care Utilizing Behavioral Activation for Depression

    Science.gov (United States)

    2015-03-01

    secured at the JBLM site. MOVI /Jabber licenses obtained for this study are still active, but due to lack of use (since the treatment phase is complete... violence are documented by study clinicians via a treatment session checklist. Our telehealth treatment session checklist was developed in part to...excluded) (h) History of violence or poor impulse control (i) Significant ongoing stressors that require urgent crisis intervention (j) Have a living

  1. Detection of specific polymerase chain reaction product by utilizing the 5'----3' exonuclease activity of Thermus aquaticus DNA polymerase.

    OpenAIRE

    1991-01-01

    The 5'----3' exonuclease activity of the thermostable enzyme Thermus aquaticus DNA polymerase may be employed in a polymerase chain reaction product detection system to generate a specific detectable signal concomitantly with amplification. An oligonucleotide probe, nonextendable at the 3' end, labeled at the 5' end, and designed to hybridize within the target sequence, is introduced into the polymerase chain reaction assay. Annealing of probe to one of the polymerase chain reaction product s...

  2. Evolution of D-lactate dehydrogenase activity from glycerol dehydrogenase and its utility for D-lactate production from lignocellulose.

    Science.gov (United States)

    Wang, Qingzhao; Ingram, Lonnie O; Shanmugam, K T

    2011-11-22

    Lactic acid, an attractive, renewable chemical for production of biobased plastics (polylactic acid, PLA), is currently commercially produced from food-based sources of sugar. Pure optical isomers of lactate needed for PLA are typically produced by microbial fermentation of sugars at temperatures below 40 °C. Bacillus coagulans produces L(+)-lactate as a primary fermentation product and grows optimally at 50 °C and pH 5, conditions that are optimal for activity of commercial fungal cellulases. This strain was engineered to produce D(-)-lactate by deleting the native ldh (L-lactate dehydrogenase) and alsS (acetolactate synthase) genes to impede anaerobic growth, followed by growth-based selection to isolate suppressor mutants that restored growth. One of these, strain QZ19, produced about 90 g L(-1) of optically pure D(-)-lactic acid from glucose in lactate dehydrogenase (D-LDH) activity was identified as a mutated form of glycerol dehydrogenase (GlyDH; D121N and F245S) that was produced at high levels as a result of a third mutation (insertion sequence). Although the native GlyDH had no detectable activity with pyruvate, the mutated GlyDH had a D-LDH specific activity of 0.8 μmoles min(-1) (mg protein)(-1). By using QZ19 for simultaneous saccharification and fermentation of cellulose to D-lactate (50 °C and pH 5.0), the cellulase usage could be reduced to 1/3 that required for equivalent fermentations by mesophilic lactic acid bacteria. Together, the native B. coagulans and the QZ19 derivative can be used to produce either L(+) or D(-) optical isomers of lactic acid (respectively) at high titers and yields from nonfood carbohydrates.

  3. [Proposition and evaluation of the educational activities for effective utilization of opioids performed by pharmacists in palliative home care].

    Science.gov (United States)

    Akai, Namika; Hashimoto, Daisuke; Fujita, Tomoko; Miyake, Keiichi; Hamabe-Fujita, Wakako; Tokuyama, Shogo

    2010-04-01

    Recently, it is required that community pharmacists participate in palliative home care. In this study, we designed educational activities for palliative home care to local residents as a new approach performed by community pharmacists. In addition, we proposed this approach to community pharmacists and discussed its roles to promote palliative home care in the future. We designed and held an educational seminar on palliative home care focusing on safe use of opioids in local residents. After this seminar, we conducted a questionnaire survey of the participants. Then, we made a proposition of this new approach by presentation of a seminar to community pharmacists (members of "Heartfulcare INC"). After the proposition, a questionnaire survey of the seminar on palliative home care was performed. In total, 79 people participated in the educational seminar. Most (87.3%) participants thought that it was informative. Furthermore, about 40% of participants answered "misunderstanding of opioids" or "anxiety regarding side effects of opioids" were removed following the seminar. All participating pharmacists evaluated the seminar as useful. The educational activity in the present study seemed effective to local residents on their misunderstanding of opioids. Furthermore, this approach was appreciated as an important role of community pharmacists in the palliative home care not only by local residents but also by pharmacists themselves. Therefore it seems important to continue such activities so as to improve palliative home care in the future.

  4. Effects of Different Substrates on Lignocellulosic Enzyme Expression, Enzyme Activity, Substrate Utilization and Biological Efficiency of Pleurotus Eryngii

    Directory of Open Access Journals (Sweden)

    Chunliang Xie

    2016-09-01

    Full Text Available Background/Aims: Pleurotus eryngii is one of the most valued and delicious mushrooms which are commercially cultivated on various agro-wastes. How different substrates affect lignocellulosic biomass degradation, lignocellulosic enzyme production and biological efficiency in Pleurotus eryngii was unclear. Methods and Results: In this report, Pleurotus eryngii was cultivated in substrates including ramie stalks, kenaf stalks, cottonseed hulls and bulrush stalks. The results showed that ramie stalks and kenaf stalks were found to best suitable to cultivate Pleurotus eryngii with the biological efficiency achieved at 55% and 57%, respectively. In order to establish correlations between different substrates and lignocellulosic enzymes expression, the extracellular proteins from four substrates were profiled with high throughput TMT-based quantitative proteomic approach. 241 non-redundant proteins were identified and 74 high confidence lignocellulosic enzymes were quantified. Most of the cellulases, hemicellulases and lignin depolymerization enzymes were highly up-regulated when ramie stalks and kenaf stalks were used as carbon sources. The enzyme activities results suggested cellulases, hemicellulases and lignin depolymerization enzymes were significantly induced by ramie stalks and kenaf stalks. Conclusion: The lignocelluloses degradation, most of the lignocellulosic enzymes expressions and activities of Pleurotus eryngii had positive correlation with the biological efficiency, which depend on the nature of lignocellulosic substrates. In addition, the lignocellulosic enzymes expression profiles during Pleurotus eryngii growth in different substrates were obtained. The present study suggested that most of the lignocellulosic enzymes expressions and activities can be used as tools for selecting better performing substrates for commercial mushroom cultivation.

  5. A call for the better utilization of physical activity and exercise training in the defense against cardiovascular disease.

    Science.gov (United States)

    Murlasits, Zsolt

    2015-11-01

    Statins, also known as 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, effectively reduce elevated levels of serum LDL-C concentration and in turn lower cardiovascular morbidity and mortality. Regular exercise and physical activity also have significant preventive effects against cardiovascular diseases by simultaneously reducing multiple risk factors. However, statins also produce a number of adverse events, including muscle pain, which increases dramatically in statin users who also exercise, likely limiting the cardiovascular benefits. Most importantly, reduced physical activity participation due to statin-related side effects can cancel out the benefits of the pharmacological treatment. Although exercise training offers more modest benefits compared to pharmacological therapy against traditional risk factors, considering the total impact of exercise on cardiovascular health, it is now evident that this intervention may offer a greater reduction of risks compared to statin therapy alone. However, primary recommendations regarding cardiovascular therapy still center around pharmacological approaches. Thus a new outlook is called for in clinical practice that provides room for physical activity and exercise training, thus lipid targets can be reached by a combined intervention along with improvements in other cardiovascular parameters, such as endothelial function and low-grade inflammation. Databases such as Pubmed and Google Scholar as well as the reference list of the relevant articles were searched to collect information for this opinion article.

  6. Activation of β3-adrenoceptors increases in vivo free fatty acid uptake and utilization in brown but not white fat depots in high-fat-fed rats.

    Science.gov (United States)

    Warner, Amy; Kjellstedt, Ann; Carreras, Alba; Böttcher, Gerhard; Peng, Xiao-Rong; Seale, Patrick; Oakes, Nicholas; Lindén, Daniel

    2016-12-01

    Activation of brown adipose tissue (BAT) and browning of white adipose tissue (WAT) present potential new therapies for obesity and type 2 diabetes. Here, we examined the effects of β3-adrenergic stimulation on tissue-specific uptake and storage of free fatty acids (FFA) and its implications for whole body FFA metabolism in diet-induced obese rats using a multi-radiotracer technique. Male Wistar rats were high fat-fed for 12 wk and administered β3-agonist CL316,243 (CL, 1 mg·kg(-1)·day(-1)) or saline via osmotic minipumps during the last 3 wk. The rats were then fasted and acutely infused with a tracer mixture ([(14)C]palmitate and the partially metabolized R-[(3)H]bromopalmitate) under anesthesia. CL infusion decreased body weight gain and fasting plasma glucose levels. While core body temperature was unaffected, infrared thermography showed an increase in tail heat dissipation following CL infusion. Interestingly, CL markedly increased both FFA storage and utilization in interscapular and perirenal BAT, whereas the flux of FFA to skeletal muscle was decreased. In this rat model of obesity, only sporadic populations of beige adipocytes were detected in the epididymal WAT depot of CL-infused rats, and there was no change in FFA uptake or utilization in WAT following CL infusion. In summary, β3-agonism robustly increased FFA flux to BAT coupled with enhanced utilization. Increased BAT activation most likely drove the increased tail heat dissipation to maintain thermostasis. Our results emphasize the quantitative role of brown fat as the functional target of β3-agonism in obesity. Copyright © 2016 the American Physiological Society.

  7. Marketing active transportation to school to improve children's health: Utilizing parental perspectives from an inner-city environment.

    Science.gov (United States)

    Royne, Marla B; Ivey, Stephanie S; Levy, Marian; Fox, Alexa K; Roakes, Susan L

    2016-01-01

    Thirty years ago, nearly half of the children in the United States walked or rode their bikes to school. Today, less than 15% of children actively commute to school. With the growing obesity epidemic, encouraging children to walk or bike to school has become a national priority. This research examines factors that influence parental decisions allowing their children to walk to school in an urban environment to identify effective marketing and communication strategies to reach those parents. Results indicate differences in parental perspectives across populations; suggestions for effectively marketing the Safe Routes to School program to minority populations are provided.

  8. The Next Generation Non-competitive Active Polyester Nanosystems for Transferrin Receptor-mediated Peroral Transport Utilizing Gambogic Acid as a Ligand.

    Science.gov (United States)

    Saini, P; Ganugula, R; Arora, M; Kumar, M N V Ravi

    2016-01-01

    The current methods for targeted drug delivery utilize ligands that must out-compete endogenous ligands in order to bind to the active site facilitating the transport. To address this limitation, we present a non-competitive active transport strategy to overcome intestinal barriers in the form of tunable nanosystems (NS) for transferrin receptor (TfR) utilizing gambogic acid (GA), a xanthanoid, as its ligand. The NS made using GA conjugated poly(lactide-co-glycolide) (PLGA) have shown non-competitive affinity to TfR evaluated in cell/cell-free systems. The fluorescent PLGA-GA NS exhibited significant intestinal transport and altered distribution profile compared to PLGA NS in vivo. The PLGA-GA NS loaded with cyclosporine A (CsA), a model peptide, upon peroral dosing to rodents led to maximum plasma concentration of CsA at 6 h as opposed to 24 h with PLGA-NS with at least 2-fold higher levels in brain at 72 h. The proposed approach offers new prospects for peroral drug delivery and beyond.

  9. High-valued Utilization of China Fir Sawdust Extracted Essential Oil: Preparation of Granular Activated Carbons for n-Butane Adsorption

    Institute of Scientific and Technical Information of China (English)

    ZHU Guang-zhen; DENG Xian-lun; LIU Xiao-min

    2011-01-01

    [Objective] The aim was to study on the high-valued utilization of China Fir sawdust extracted essential oil. [Method] In the field of fir essential oil extraction, the processed China fir sawdust was used to prepare low-valued products. The high-valued utilization of China fir sawdust extracted essential oil (CFSEEO), namely as a precursor to prepare granular activated carbons (GACs), was attempted. The materials were characterized by ultimate analysis, SEM and XRD. [Rusult] A butane working capacity (BWC) of 14.3 g/100 ml was obtained by using the GACs with apparent density of 0.25 g/ml. It was available to introduce the technology of extracting essential oil from the China fir sawdust (CFS) in the industrial production process of activated carbons with high BWC (12.0 -16.5 g/100 ml) and high surface area (2 000 -2 630m2/g) using phosphoric acid based on previous studies of the authors. [Conclusion] The resulting carbon prepared with the raw materials containing lower moisture exhibited a better property on n-butane adsorption.

  10. Estrogen secreting adrenal adenocarcinoma in an 18-month-old boy: aromatase activity, protein expression, mRNA and utilization of gonadal type promoter.

    Science.gov (United States)

    Watanabe, T; Yasuda, T; Noda, H; Wada, K; Kazukawa, I; Someya, T; Minamitani, K; Minagawa, M; Wataki, K; Matsunaga, T; Ohnuma, N; Kohno, Y; Harada, N

    2000-12-01

    We examined clinical, endocrinological and molecular biological aspects of an estrogen-secreting adrenal carcinoma in an 18-month-old male to clarify the pathogenesis of this condition. An 18-month-old boy was referred for evaluation of progressive bilateral gynecomastia and appearance of pubic hair. The patient had elevated plasma estradiol (349 pg/ml) and testosterone (260 ng/dl) levels that completely suppressed FSH and LH levels, and was subsequently diagnosed with an adrenal tumor on the right side. After removal of a 300-g adenocarcinoma, gynecomastia regressed and essentially normal hormone levels were restored. Aromatase activity in the tumor tissue determined by the 3H-water method was 71.0-104.4 pmol/min/mg protein. High levels of aromatase protein and mRNA in the tumor tissue were also demonstrated, while neither aromatase activity nor protein was detected in normal adrenal glands. To investigate the regulation of aromatase expression in the adrenal carcinoma, we examined the usage of alternate promoters responsible for aromatase gene transcription. In the present case, the amounts of aromatase mRNA utilizing gonadal types of exon 1c (1.3) and 1d (II) were significantly higher than those that using other exon 1s. This result suggested that the utilization of a gonadal-type exon 1 might be involved in the over-production of aromatase in estrogen-secreting adrenal carcinoma.

  11. The Hansenula polymorpha MOX gene presents two alternative transcription start points differentially utilized and sensitive to respiratory activity.

    Science.gov (United States)

    Genu, Victor; Gödecke, Stefanie; Hollenberg, Cornelis P; Pereira, Gonçalo G

    2003-06-01

    The peroxisomal methanol metabolism of Hansenula polymorpha depends on a group of genes that are coordinately regulated. Methanol oxidase (Mox) plays a key role in this pathway and its synthesis has been shown to be regulated at the transcriptional level. MOX expression is strongly repressed on glucose and activated on glycerol or methanol. In this study we have identified two MOX transcripts that are differentially expressed along MOX derepression. The first one, named l-MOX (for longer MOX), starts at position -425, is only weakly and transiently transcribed and is not translated into the Mox protein. The other is the true MOX mRNA, which initiates around position -25. Using a strain bearing multiple copies of MOX(Q1N) and a reporter gene fused to the MOX promoter, regulation of the two transcripts was investigated. Initiation of the true MOX correlates with repression of l-MOX and conditions that are repressive for MOX transcription, such as the inhibition of mitochondrial activity, lead to higher levels of l-MOX expression. This effect was first observed in a mox mutant (Q1N-M8) unable to grow on nonfermentable carbon sources. No function was detected for l-MOX, but its regulation follows a pattern similar to that of catalase, which is essential for methanol metabolism. This suggests that, l-MOX, although precisely regulated, seems to be a remnant of the evolution of the methanol metabolism network.

  12. Utility of Activated Glassy Carbon and Pencil Graphite Electrodes for Voltammetric Determination of Nalbuphine Hydrochloride in Pharmaceutical and Biological Fluids

    Directory of Open Access Journals (Sweden)

    Hoda M. Elqudaby

    2016-01-01

    Full Text Available This work compares voltammetric response of nalbuphine hydrochloride (NP·HCl at both activated glassy carbon and pencil graphite electrodes. The electrochemical oxidation of the drug was studied using cyclic voltammetry (CV, differential pulse voltammetry (DPV, and square wave voltammetry (SWV techniques. For analytical purpose a well-resolved irreversible diffusion controlled voltammetric peak was established in Britton-Robinson (B-R buffer solution of pH 6.00 using pencil graphite electrode (PGE. Using activated glassy carbon electrode (GCE a well-resolved irreversible diffusion controlled voltammetric peak was obtained at pH 7.00 using the same buffer solution. According to the linear relationship between the peak current and NP·HCl concentration, DPV and SWV methods were developed for their quantitative determination in pharmaceutical and human biological fluids. The linear response was obtained in the range from 1.6×10-5 to 1.5×10-4 mol L−1 using PGE and from 12.5×10-6 to 13.75×10-5 mol L−1 using a GC electrode, respectively. Precision and accuracy of the developed method were checked by recovery studies.

  13. Human Control Law and Brain Activity of Voluntary Motion by Utilizing a Balancing Task with an Inverted Pendulum

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    Satoshi Suzuki

    2010-01-01

    Full Text Available Human characteristics concerning voluntary motion control are investigated, because this motion is fundamental for the machine operation and human-computer system. Using a force feedback haptic device and a balancing task of a virtual inverted pendulum, participants were trained in the task, and hand motion/force was measured, and brain activity was monitored. First, through brain analysis by near-infrared spectroscopy (NIRS and motion analysis of the pendulum, we identified a participant who was the most expert. Next, control characteristics of the most expert were investigated by considering the operational force and delay factor of a human. As a result, it was found that predictive control based on velocity information was used predominantly although a perception feedback control against the pendulum posture worked. And it was shown that an on-off intermittency control, which was a strategy for the skilled balancing, can be described well by a liner model involving two types of time shifts for the position and velocity. In addition, it was confirmed that the cortex activity for observation in an ocular motor control area and visual processing area was strong to enhance above-mentioned control strategies.

  14. [Effects of elevated atmospheric CO2 and nitrogen application on cotton biomass, nitrogen utilization and soil urease activity].

    Science.gov (United States)

    Lyu, Ning; Yin, Fei-hu; Chen, Yun; Gao, Zhi-jian; Liu, Yu; Shi, Lei

    2015-11-01

    In this study, a semi-open-top artificial climate chamber was used to study the effect of CO2 enrichment (360 and 540 µmol · mol(-1)) and nitrogen addition (0, 150, 300 and 450 kg · hm(-2)) on cotton dry matter accumulation and distribution, nitrogen absorption and soil urease activity. The results showed that the dry matter accumulation of bud, stem, leaf and the whole plant increased significantly in the higher CO2 concentration treatment irrespective of nitrogen level. The dry matter of all the detected parts of plant with 300 kg · hm(-2) nitrogen addition was significantly higher than those with the other nitrogen levels irrespective of CO2 concentration, indicating reasonable nitrogen fertilization could significantly improve cotton dry matter accumulation. Elevated CO2 concentration had significant impact on the nitrogen absorption contents of cotton bud and stem. Compared to those under CO2 concentration of 360 µmol · mol(-1), the nitrogen contents of bud and stem both increased significantly under CO2 concentration of 540 µmol · mol(-1). The nitrogen content of cotton bud in the treatment of 300 kg · hm(-2) nitrogen was the highest among the four nitrogen fertilizer treatments. While the nitrogen contents of cotton stem in the treatments of 150 kg · hm(-2) and 300 kg · hm(-2) nitrogen levels were higher than those in the treatment of 0 kg · hm(-2) and 450 kg · hm(-2) nitrogen levels. The nitrogen content of cotton leaf was significantly influenced by the in- teraction of CO2 elevation and N addition as the nitrogen content of leaf increased in the treatments of 0, 150 and 300 kg · hm(-2) nitrogen levels under the CO2 concentration of 540 µmol · mol(-1). The nitrogen content in cotton root was significantly increased with the increase of nitrogen fertilizer level under elevated CO2 (540 µmol · mol(-1)) treatment. Overall, the cotton nitrogen absorption content under the elevated CO2 (540 µmol · mol(-1)) treatment was higher than that

  15. Map, Excite, Jump, and Measure: An Outreach Activity That Utilizes Seismology to Engage Students in Technology, Science, Engineering, and Mathematics

    Science.gov (United States)

    van der Lee, S.; Tekverk, K.; Rooney, K.; Boxerman, J.

    2013-12-01

    We designed and will present a lesson plan to teach students STEM concepts through seismology. The plan addresses new generation science standards in the Framework for K-12 Science Education as well AAAS Benchmarks for Science Literacy. The plan can be executed at a facility with a seismometer in a research facility or university, on a field trip, but it can also be used in a school setting with a school seismometer. Within the lesson plan, the students first use technology to obtain earthquake location data and map them. Next, the students learn about the science of earthquakes, which is followed by an engineering activity in which the students design a hypothetical seismometer and interact with the actual seismometer and live data display. Lastly the students use mathematics to locate an earthquake through trilateration. The lesson plan has been fine-tuned through implementation with over 150 students from grades 3-12 from the Chicago area.

  16. Utility of a redox-active pyridine(diimine) chelate in facilitating two electron oxidative addition chemistry at uranium.

    Science.gov (United States)

    Kiernicki, John J; Fanwick, Phillip E; Bart, Suzanne C

    2014-08-01

    Exposure of the uranium(IV) complex, Cp(P)U((Mes)PDI(Me)) (1) ((Mes)PDI(Me) = 2,6-((Mes)N=CMe)2–C5H3N; Mes = 2,4,6-trimethylphenyl; Cp(P) = 1-(7,7-dimethylbenzyl)cyclopentadienyl), which contains a [(Mes)PDI(Me)](3−) chelate, to I2, Cl2, PhSeCl, and PhEEPh (E = S, Se, Te) results in oxidative addition to form the uranium(IV) family, Cp(P)U(XX′)((Mes)PDI(Me)) (X = X′ = I, Cl, EPh; X = SePh, X′ = Cl). Spectroscopic and structural studies support products with [(Mes)PDI(Me)](1−), indicating the reducing equivalents derive from this redox-active chelate.

  17. Lack of utility of risk score and gynecological examination for screening for sexually transmitted infections in sexually active adolescents

    Directory of Open Access Journals (Sweden)

    Côrtes Rejane LM

    2009-03-01

    Full Text Available Abstract Background Sexually transmitted infections constitute the main health risk among adolescents. In developing countries the diagnosis and treatment of cervical infections is based on the syndromic approach. In this study we estimated the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae among female adolescents from a Health Sector of the city of Goiânia, Brazil, and validated cervicitis diagnosis using World Health Organization/Ministry of Health risk score and gynecological examination. Methods A cross-sectional community-based sample of 914 15- to 19-year-old female teenagers was randomly selected and referred to the local Family Health Program. Of these, 472 (51.6% were sexually active and gynecological examinations were carried out for 427. Endocervical samples were collected to perform the polymerase chain reaction for C. trachomatis and N. gonorrhoeae. Performance of risk score, the presence of mucopurulent discharge, friability, ectopia and pain during cervical maneuver were compared with the presence of C. trachomatis or N. gonorrhoeae or both. Results The prevalence of C. trachomatis and N. gonorrhoeae was 14.5% and 2.1%, respectively. The risk score had a specificity of 31.9% (95% confidence interval, 21.2 to 44.2 and a positive predictive value of 20.8% (95% confidence interval, 13.5 to 29.7. Friability was the component of the gynecological examination that presented the best performance with a sensitivity of 43.5%, specificity of 81.0%, and 30.6% of positive predictive value. Conclusion The prevalence of infection by C. trachomatis and N. gonorrhoeae was high among these sexually active adolescents. The syndromic approach is clearly inadequate for screening and treating these infections in this population. Therefore, the implantation of other strategies to control these infections among adolescents is urgently required.

  18. Selective utilization of exogenous amino acids by Dehalococcoides ethenogenes strain 195 and its effects on growth and dechlorination activity.

    Science.gov (United States)

    Zhuang, Wei-Qin; Yi, Shan; Feng, Xueyang; Zinder, Stephen H; Tang, Yinjie J; Alvarez-Cohen, Lisa

    2011-11-01

    Bacteria of the genus Dehalococcoides are important members of bioremediation communities because of their ability to detoxify chloroethenes to the benign end product ethene. Genome-enabled studies conducted with Dehalococcoides ethenogenes 195 have revealed that two ATP-binding cassette (ABC)-type amino acid transporters are expressed during its exponential growth stages. In light of previous findings that Casamino Acids enhanced its dechlorination activity, we hypothesized that strain 195 is capable of importing amino acids from its environment to facilitate dechlorination and growth. To test this hypothesis, we applied isotopomer-based dilution analysis with (13)C-labeled acetate to differentiate the amino acids that were taken up by strain 195 from those synthesized de novo and to determine the physiological changes caused by the significantly incorporated amino acids. Our results showed that glutamate/glutamine and aspartate/asparagine were almost exclusively synthesized by strain 195, even when provided in excess in the medium. In contrast, phenylalanine, isoleucine, leucine, and methionine were identified as the four most highly incorporated amino acids, at levels >30% of respective proteinogenic amino acids. When either phenylalanine or all four highly incorporated amino acids were added to the defined mineral medium, the growth rates, dechlorination activities, and yields of strain 195 were enhanced to levels similar to those observed with supplementation with 20 amino acids. However, genes for the putative ABC-type amino acids transporters and phenylalanine biosynthesis exhibited insignificant regulation in response to the imported amino acids. This study also demonstrates that using isotopomer-based metabolite analysis can be an efficient strategy for optimizing nutritional conditions for slow-growing microorganisms.

  19. Active induction balance method for metal detector sensing head utilizing transmitter-bucking and dual current source

    Science.gov (United States)

    Ambruš, D.; Vasić, D.; Bilas, V.

    2013-06-01

    A central problem in a design of frequency domain electromagnetic induction sensors used in landmine detection is an effective suppression of a direct inductive coupling between the transmitter and the receiver coil (induction balance, IB). In sensing heads based on the transmitter-bucking configuration, IB is achieved by using two concentric transmitter coils with opposing exciter fields in order to create a central magnetic cavity for the receiver coil. This design has numerous advantages over other IB methods in terms of detection sensitivity, spatial resolution, sensor dimensions and suitability for model-based measurements. However, very careful design and precise sensing head geometry are required if a single excitation source is used for driving both transmitter coils. In this paper we analyze the IB sensitivity to small perturbations of geometrical properties of coils. We propose a sensor design with dual current source and active induction balance scheme which overcomes the limitations of geometry-based balancing and potentially provides more efficient compensation of soil effects.

  20. Impact of the Staphylococcus epidermidis LytSR two-component regulatory system on murein hydrolase activity, pyruvate utilization and global transcriptional profile

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    Yu Fangyou

    2010-11-01

    Full Text Available Abstract Background Staphylococcus epidermidis has emerged as one of the most important nosocomial pathogens, mainly because of its ability to colonize implanted biomaterials by forming a biofilm. Extensive studies are focused on the molecular mechanisms involved in biofilm formation. The LytSR two-component regulatory system regulates autolysis and biofilm formation in Staphylococcus aureus. However, the role of LytSR played in S. epidermidis remained unknown. Results In the present study, we demonstrated that lytSR knock-out in S. epidermidis did not alter susceptibility to Triton X-100 induced autolysis. Quantitative murein hydrolase assay indicated that disruption of lytSR in S. epidermidis resulted in decreased activities of extracellular murein hydrolases, although zymogram showed no apparent differences in murein hydrolase patterns between S. epidermidis strain 1457 and its lytSR mutant. Compared to the wild-type counterpart, 1457ΔlytSR produced slightly more biofilm, with significantly decreased dead cells inside. Microarray analysis showed that lytSR mutation affected the transcription of 164 genes (123 genes were upregulated and 41 genes were downregulated. Specifically, genes encoding proteins responsible for protein synthesis, energy metabolism were downregulated, while genes involved in amino acid and nucleotide biosynthesis, amino acid transporters were upregulated. Impaired ability to utilize pyruvate and reduced activity of arginine deiminase was observed in 1457ΔlytSR, which is consistent with the microarray data. Conclusions The preliminary results suggest that in S. epidermidis LytSR two-component system regulates extracellular murein hydrolase activity, bacterial cell death and pyruvate utilization. Based on the microarray data, it appears that lytSR inactivation induces a stringent response. In addition, LytSR may indirectly enhance biofilm formation by altering the metabolic status of the bacteria.

  1. Is Self-Reported Physical Activity Participation Associated with Lower Health Services Utilization among Older Adults? Cross-Sectional Evidence from the Canadian Community Health Survey

    Directory of Open Access Journals (Sweden)

    Koren L. Fisher

    2015-01-01

    Full Text Available Purpose. To examine relationships between leisure time physical activity (LTPA and health services utilization (H in a nationally representative sample of community-dwelling older adults. Methods. Cross-sectional data from 56,652 Canadian Community Health Survey respondents aged ≥ 50 years (48% M; 52% F; mean age 63.5 ± 10.2 years were stratified into three age groups and analysed using multivariate generalized linear modeling techniques. Participants were classified according to PA level based on self-reported daily energy expenditure. Nonleisure PA (NLPA was categorized into four levels ranging from mostly sitting to mostly lifting objects. Results. Active 50–65-year-old individuals were 27% less likely to report any GP consultations ORadj=0.73; P<0.001 and had 8% fewer GP consultations annually (IRRadj=0.92; P<0.01 than their inactive peers. Active persons aged 65–79 years were 18% less likely than inactive respondents to have been hospitalized overnight in the previous year (ORadj=0.82, P<0.05. Higher levels of NLPA were significantly associated with lower levels of HSU, across all age groups. Conclusion. Nonleisure PA appeared to be a stronger predictor of all types of HSU, particularly in the two oldest age groups. Considering strategies that focus on reducing time spent in sedentary activities may have a positive impact on reducing the demand for health services.

  2. The Utility of the OMI HCHO and NO2 Data Products in Air Quality Decision- Making Activities

    Science.gov (United States)

    Duncan, Bryan N.

    2010-01-01

    We will present three related air quality applications of the OMI HCHO (formaldehyde) and NO2 (nitrogen dioxide) data products, which we us to support mission planning of an OMI-like instrument for the proposed GEO-CAPE satellite that has as one of its objectives to study air quality from space. First, we will discuss a novel and practical application of the data products to the "weight of evidence" in the air quality decision-making process (e.g., State Implementation Plan (SIP)) for a city, region, or state to demonstrate that it is making progress toward attainment of the National Ambient Air Quality Standard (NAAQS) for ozone. Any trend, or lack thereof, in the observed OMI HCHO/NO2, which we use as an air quality indicator, may support that an emission control strategy implemented to reduce ozone is or is not occurring for a metropolitan area. Second, we will discuss how we use variations in the OMI HCHO product as a proxy for variability in the biogenic hydrocarbon, isoprene, which is an important player for the formation of high levels of ozone and the dominant source of HCHO in the eastern U.S. Third, we will discuss the variability of NO2 in the U.S. as indicated by the OMI NO2 product. In addition, we will show the impact of the 2005 hurricanes on pollutant emissions, including those associated with the intensive oil extraction and refining activities, in the Gulf of Mexico region using the OMI NO2 product. The variability of HCHO and NO2 as indicated by OMI helps us to understand changes in the OMI HCHO/NO2 and the implications for ozone formation.

  3. The Utility of the OMI HCHO and NO2 Data Products in Air Quality Decision- Making Activities

    Science.gov (United States)

    Duncan, Bryan N.

    2010-01-01

    We will present three related air quality applications of the OMI HCHO (formaldehyde) and NO2 (nitrogen dioxide) data products, which we us to support mission planning of an OMI-like instrument for the proposed GEO-CAPE satellite that has as one of its objectives to study air quality from space. First, we will discuss a novel and practical application of the data products to the "weight of evidence" in the air quality decision-making process (e.g., State Implementation Plan (SIP)) for a city, region, or state to demonstrate that it is making progress toward attainment of the National Ambient Air Quality Standard (NAAQS) for ozone. Any trend, or lack thereof, in the observed OMI HCHO/NO2, which we use as an air quality indicator, may support that an emission control strategy implemented to reduce ozone is or is not occurring for a metropolitan area. Second, we will discuss how we use variations in the OMI HCHO product as a proxy for variability in the biogenic hydrocarbon, isoprene, which is an important player for the formation of high levels of ozone and the dominant source of HCHO in the eastern U.S. Third, we will discuss the variability of NO2 in the U.S. as indicated by the OMI NO2 product. In addition, we will show the impact of the 2005 hurricanes on pollutant emissions, including those associated with the intensive oil extraction and refining activities, in the Gulf of Mexico region using the OMI NO2 product. The variability of HCHO and NO2 as indicated by OMI helps us to understand changes in the OMI HCHO/NO2 and the implications for ozone formation.

  4. Commercial activities and subsistence utilization of mangrove forests around the Wouri estuary and the Douala-Edea reserve (Cameroon

    Directory of Open Access Journals (Sweden)

    Dahdouh-Guebas Farid

    2009-11-01

    Full Text Available Abstract Background Worldwide there is growing research interest in the ethnobiology of mangrove forests. Notwithstanding that, little information has been published about ethnobiology of mangrove forests in Cameroon. The aims of this study were a to analyze the harvesting methods and the local selling of mangrove wood products by loggers in the vicinity of Wouri estuary and b to investigate the patterns of subsistence uses of mangrove wood products around the Douala-Edea reserve. Methods Semi-structured interviews were conducted with 120 active mangrove loggers in 23 Douala wood markets and 103 households located in three villages (Mbiako, Yoyo I and Yoyo II close to Douala-Edea reserve. In each of the three densely populated villages, every second household was chosen for sampling while in all markets, mangrove loggers were chosen randomly. In addition, log diameters were measured in each market using a wooden foldable tape measure. A post hoc analysis (Newman-Keuls test was performed in order to detect the common wood class diameter sold in the Douala wood markets. Results The analysis of the loggers' survey data has shown that large logs of Rhizophora with diameter greater than 40 cm were common in the Douala wood markets and were more closely associated with loggers who used chainsaws. In addition to the general mangroves wood products selling, the analysis on a subsistence level (households' survey suggests the local population's dependence on mangroves, with multiple uses of Rhizophora racemosa Meyer, R. harrisonii Leechman, Avicennia germinans L. Stearn., Laguncularia racemosa Gaertn. f. and Conocarpus erectus L. timbers for furniture, fences, smoking fish, and fuelwood. Finally, Nypa fruticans (Thunb. Wurmb. leaves were used as thatching material for house walls and roofs. Conclusion Our findings revealed that big logs of Rhizophora were commonly sold by the loggers. A majority of loggers (60% reported that mangrove marketed wood

  5. Utilizing an Extraterrestrial Analogue to Predict Sediment Migration on Frenchman Flat due to Convective Vortex (Dust Devil) Activity

    Science.gov (United States)

    McGee, B. W.

    2006-12-01

    data from the NTS, and combining them with measurements of sediment loading and erosive strength in terrestrial dust devils, it is possible to both illustrate the potential significance of dust devils to currently-accepted radionuclide residence time on Frenchman Flat playa, as well as predict areas of unexpected radionuclide migration and/or attenuation due to dust devil activity.

  6. Male Adolescent Contraceptive Utilization.

    Science.gov (United States)

    Finkel, Madelon Lubin; Finkel, David J.

    1978-01-01

    The contraceptive utilization of a sample of sexually active, urban, high school males (Black, Hispanic, and White) was examined by anonymous questionnaire. Contraceptive use was haphazard, but White males tended to be more effective contraceptors than the other two groups. Reasons for nonuse were also studied. (Author/SJL)

  7. Identifying Low pH Active and Lactate-Utilizing Taxa within Oral Microbiome Communities from Healthy Children Using Stable Isotope Probing Techniques

    Energy Technology Data Exchange (ETDEWEB)

    McLean, Jeffrey S.; Fansler, Sarah J.; Majors, Paul D.; Mcateer, Kathleen; Allen, Lisa Z.; Shirtliff, Mark E.; Lux, Renate; Shi, Wenyuan

    2012-03-05

    Many human microbial infectious diseases including dental caries are polymicrobial in nature and how these complex multi-species communities evolve from a healthy to a diseased state is not well understood. Although many health- or disease-associated oral microbes have been characterized in vitro, their physiology in vivo in the presence of the complex oral microbiome is difficult to determine with current approaches. In addition, about half of these oral species remain uncultivated to date and little is known except their 16S rRNA sequence. Lacking culture-based physiological analyses, the functional roles of uncultivated microorganisms will remain enigmatic despite their apparent disease correlation. To start addressing these knowledge gaps, we applied a novel combination of in vivo Magnetic Resonance Spectroscopy (MRS) with RNA and DNA based Stable Isotope Probing (SIP) to oral plaque communities from healthy children for temporal monitoring of carbohydrate utilization, organic acid production and identification of metabolically active and inactive bacterial species.

  8. Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach.

    Science.gov (United States)

    Anan, Kosuke; Masui, Moriyasu; Hara, Shinichiro; Ohara, Miho; Kume, Masaharu; Yamamoto, Shoichi; Shinohara, Shunji; Tsuji, Hiroki; Shimada, Shinji; Yagi, Shigenori; Hasebe, Nobuyoshi; Kai, Hiroyuki

    2017-09-01

    NR2B subunit containing N-methyl-d-aspartate (NMDA) receptor is an attractive target for chronic pain due to its involvement in disease states and its limited distribution in the central nervous system. Cyclohexanol-based leads 6a and 6c were identified as potent NR2B-selective NMDA antagonists utilizing a scaffold hopping approach. Further optimization of this series through replacement of the amide in the leads with an isoxazole and efforts to optimize the pharmacokinetic profiles led to the discovery of orally available brain penetrants 7k and 7l, which demonstrated analgesic activity in the mouse formalin test at early and late phases. Copyright © 2017. Published by Elsevier Ltd.

  9. Application of solid waste from anaerobic digestion of poultry litter in Agrocybe aegerita cultivation: mushroom production, lignocellulolytic enzymes activity and substrate utilization.

    Science.gov (United States)

    Isikhuemhen, Omoanghe S; Mikiashvili, Nona A; Kelkar, Vinaya

    2009-06-01

    The degradation and utilization of solid waste (SW) from anaerobic digestion of poultry litter by Agrocybe aegerita was evaluated through mushroom production, loss of organic matter (LOM), lignocellulolytic enzymes activity, lignocellulose degradation and mushroom nutrients content. Among the substrate combinations (SCs) tested, substrates composed of 10-20% SW, 70-80% wheat straw and 10% millet was found to produce the highest mushroom yield (770.5 and 642.9 g per 1.5 kg of substrate). LOM in all SCs tested varied between 8.8 and 48.2%. A. aegerita appears to degrade macromolecule components (0.6-21.8% lignin, 33.1-55.2% cellulose and 14-53.9% hemicellulose) during cultivation on the different SCs. Among the seven extracellular enzymes monitored, laccase, peroxidase and CMCase activities were higher before fruiting; while xylanase showed higher activities after fruiting. A source of carbohydrates (e.g., millet) in the substrate is needed in order to obtain yield and biological efficiency comparable to other commercially cultivated exotic mushrooms.

  10. Gestão de custos florestais: um estudo de caso utilizando o Activity-Based Costing Forest management costs: a case study utilizing Activity-Based Costing

    Directory of Open Access Journals (Sweden)

    Alcir Ribeiro Carneiro de Almeida

    1999-08-01

    Full Text Available No atual cenário de industrialização globalizada, tornou-se fundamental a eficácia no gerenciamento dos custos considerados inevitavelmente necessários. Programas convencionais de redução dos custos não consideram o grau de agregação de valor das atividades de rotina pela distorção dos sistemas contábeis atuais. No presente estudo, apresentam-se os principais motivos da falta de relevância das informações de custo, comenta-se sobre o problema da redução de desperdícios florestais e suas conseqüências. A partir de um estudo de caso em uma empresa do setor florestal, demonstra-se uma simulação do Activity Based Costing (ABC em uma determinada área da empresa, concluindo-se que a adoção de sistemas de custeio mais aprimorados, tal como o ABC, devem fazer parte de programas que busquem o aumento da competitividade do setor florestal.In the current view of globalized industrialization, it has become fundamental to manage essential costs effectively. Conventional programs for reducing costs, do no consider the value agregation grade of routine activities because of the distortion of current accounting systems. This study, presents the main reasons for the lack of relevance of the cost information, commenting on the problem of the reduction of forest waste and its consequences. Using a case study in a company from the forest sector, a simulation of Activity Based Costing (ABC is demonstrated in a determined area of the company it is concluded that the adoption of a more refined cost system, such as the ABC, should be included in programs, that seek to increase the competitiveness of the forest sector.

  11. A comparison of red blood cell transfusion utilization between anti-activated factor X and activated partial thromboplastin monitoring in patients receiving unfractionated heparin.

    Science.gov (United States)

    Belk, K W; Laposata, M; Craver, C

    2016-11-01

    Essentials Anti-activated factor X (Anti-Xa) monitoring is more precise than activated partial thromboplastin (aPTT). 20 804 hospitalized cardiovascular patients monitored with Anti-Xa or aPTT were analyzed. Adjusted transfusion rates were significantly lower for patients monitored with Anti-Xa. Adoption of Anti-Xa protocols could reduce transfusions among cardiovascular patients in the US. Background Anticoagulant activated factor X protein (Anti-Xa) has been shown to be a more precise monitoring tool than activated partial thromboplastin time (aPTT) for patients receiving unfractionated heparin (UFH) anticoagulation therapy. Objectives To compare red blood cell (RBC) transfusions between patients receiving UFH who are monitored with Anti-Xa and those monitored with aPTT. Patients/Methods A retrospective cohort study was conducted on patients diagnosed with acute coronary syndrome (ACS) (N = 14 822), diagnosed with ischemic stroke (STK) (N = 1568) or with a principal diagnosis of venous thromboembolism (VTE) (N = 4414) in the MedAssets data from January 2009 to December 2013. Anti-Xa and aPTT groups were identified from hospital billing details, with both brand and generic name as search criteria. Propensity score techniques were used to match Anti-Xa cases to aPTT controls. RBC transfusions were identified from hospital billing data. Multivariable logistic regression was used to identify significant drivers of transfusions. Results Anti-Xa patients had fewer RBC transfusions than aPTT patients in the ACS population (difference 17.5%; 95% confidence interval [CI] 16.4-18.7%), the STK population (difference 8.2%; 95% CI 4.4-11.9%), and the VTE population (difference 4.7%; 95% CI 3.3-6.1%). After controlling for patient age and gender, diagnostic risks (e.g. anemia, renal insufficiency, and trauma), and invasive procedures (e.g. cardiac catheterization, hemodialysis, and coronary artery bypass graft), Anti-Xa patients were less likely to have a transfusion while

  12. The effect of priming exercise on O2 uptake kinetics, muscle O2 delivery and utilization, muscle activity, and exercise tolerance in boys.

    Science.gov (United States)

    Barker, Alan R; Trebilcock, Emily; Breese, Brynmor; Jones, Andrew M; Armstrong, Neil

    2014-03-01

    This study used priming exercise in young boys to investigate (i) how muscle oxygen delivery and oxygen utilization, and muscle activity modulate oxygen uptake kinetics during exercise; and (ii) whether the accelerated oxygen uptake kinetics following priming exercise can improve exercise tolerance. Seven boys that were aged 11.3 ± 1.6 years completed either a single bout (bout 1) or repeated bouts with 6 min of recovery (bout 2) of very heavy-intensity cycling exercise. During the tests oxygen uptake, muscle oxygenation, muscle electrical activity and exercise tolerance were measured. Priming exercise most likely shortened the oxygen uptake mean response time (change, ±90% confidence limits; -8.0 s, ±3.0), possibly increased the phase II oxygen uptake amplitude (0.11 L·min(-1), ±0.09) and very likely reduced the oxygen uptake slow component amplitude (-0.08 L·min(-1), ±0.07). Priming resulted in a likely reduction in integrated electromyography (-24% baseline, ±21% and -25% baseline, ±19) and a very likely reduction in Δ deoxyhaemoglobin/Δoxygen uptake (-0.16, ±0.11 and -0.09, ±0.05) over the phase II and slow component portions of the oxygen uptake response, respectively. A correlation was present between the change in tissue oxygenation index during bout 2 and the change in the phase II (r = -0.72, likely negative) and slow component (r = 0.72, likely positive) oxygen uptake amplitudes following priming exercise, but not for muscle activity. Exercise tolerance was likely reduced (change -177 s, ±180) following priming exercise. The altered phase II and slow component oxygen uptake amplitudes in boys following priming exercise are linked to an improved localised matching of muscle oxygen delivery to oxygen uptake and not muscle electrical activity. Despite more rapid oxygen uptake kinetics following priming exercise, exercise tolerance was not enhanced.

  13. Alterations in grooming activity and syntax in heterozygous SERT and BDNF knockout mice: the utility of behavior-recognition tools to characterize mutant mouse phenotypes.

    Science.gov (United States)

    Kyzar, Evan J; Pham, Mimi; Roth, Andrew; Cachat, Jonathan; Green, Jeremy; Gaikwad, Siddharth; Kalueff, Allan V

    2012-12-01

    Serotonin transporter (SERT) and brain-derived neurotrophic factor (BDNF) are key modulators of molecular signaling, cognition and behavior. Although SERT and BDNF mutant mouse phenotypes have been extensively characterized, little is known about their self-grooming behavior. Grooming represents an important behavioral domain sensitive to environmental stimuli and is increasingly used as a model for repetitive behavioral syndromes, such as autism and attention deficit/hyperactivity disorder. The present study used heterozygous ((+/-)) SERT and BDNF male mutant mice on a C57BL/6J background and assessed their spontaneous self-grooming behavior applying both manual and automated techniques. Overall, SERT(+/-) mice displayed a general increase in grooming behavior, as indicated by more grooming bouts and more transitions between specific grooming stages. SERT(+/-) mice also aborted more grooming bouts, but showed generally unaltered activity levels in the observation chamber. In contrast, BDNF(+/-) mice displayed a global reduction in grooming activity, with fewer bouts and transitions between specific grooming stages, altered grooming syntax, as well as hypolocomotion and increased turning behavior. Finally, grooming data collected by manual and automated methods (HomeCageScan) significantly correlated in our experiments, confirming the utility of automated high-throughput quantification of grooming behaviors in various genetic mouse models with increased or decreased grooming phenotypes. Taken together, these findings indicate that mouse self-grooming behavior is a reliable behavioral biomarker of genetic deficits in SERT and BDNF pathways, and can be reliably measured using automated behavior-recognition technology.

  14. Evaluation of a Trapezoidal Predictive Controller for a Four-Wire Active Power Filter for Utility Equipment of Metro Railway, Power-Land Substations

    Directory of Open Access Journals (Sweden)

    Sergio Salas-Duarte

    2016-01-01

    Full Text Available The realization of an improved predictive current controller based on a trapezoidal model is described, and the impact of this technique is assessed on the performance of a 2 kW, 21.6 kHz, four-wire, Active Power Filter for utility equipment of Metro Railway, Power-Land Substations. The operation of the trapezoidal predictive current controller is contrasted with that of a typical predictive control technique, based on a single Euler approximation, which has demonstrated generation of high-quality line currents, each using a 400 V DC link to improve the power quality of an unbalanced nonlinear load of Metro Railway. The results show that the supply current waveforms become virtually sinusoidal waves, reducing the current ripple by 50% and improving its power factor from 0.8 to 0.989 when the active filter is operated with a 1.6 kW load. The principle of operation of the trapezoidal predictive controller is analysed together with a description of its practical development, showing experimental results obtained with a 2 kW prototype.

  15. Utilization of actinide as cell active materials. JAERI's nuclear research promotion program, H10-034-1. Contract research

    Energy Technology Data Exchange (ETDEWEB)

    Shiokawa, Yoshinobu; Yamamura, Tomoo; Watanabe, Nobutaka; Umekita, Satoshi [Tohoku University, Institute for Materials Research, Sendai, Miyagi (Japan)

    2002-03-01

    The electrochemical properties of U, Np, Pu and Am were discussed from the viewpoint of cell active materials From the thermodynamic properties and the kinetics of electrode reactions, it is found that neptunium in the aqueous system and some uranium complexes in the polar aprotic solvents can be utilized as an active material of the redox flow battery for the electric power storage. Moreover, A new actinide redox battery is proposed in the present article: the galvanic cell is expressed by Electrode(-) |An{sup 3+}, An{sup 4+}| |AnO{sub 2}{sup +}, AnO{sub 2}{sup 2+}| Electrode(+). The actinide batteries are expected to have more excellent charge and discharge performance than the current vanadium battery because of the great similarity of chemical species in the each redox couple. The standard rate constants and formal potential of Np(VI)/Np(V) and Np(IV)/Np(III) couples were determined by the cyclic voltammetry and the neptunium battery was demonstrated. For the development of uranium redox flow battery, the redox reaction mechanisms and redox potentials of uranium -diketones including new -tetraketones were elucidated and it was found the open circuit voltage is increased with the acid dissociation constant of the ligand. (author)

  16. [Clinical study using activity-based costing to assess cost-effectiveness of a wound management system utilizing modern dressings in comparison with traditional wound care].

    Science.gov (United States)

    Ohura, Takehiko; Sanada, Hiromi; Mino, Yoshio

    2004-01-01

    In recent years, the concept of cost-effectiveness, including medical delivery and health service fee systems, has become widespread in Japanese health care. In the field of pressure ulcer management, the recent introduction of penalty subtraction in the care fee system emphasizes the need for prevention and cost-effective care of pressure ulcer. Previous cost-effectiveness research on pressure ulcer management tended to focus only on "hardware" costs such as those for pharmaceuticals and medical supplies, while neglecting other cost aspects, particularly those involving the cost of labor. Thus, cost-effectiveness in pressure ulcer care has not yet been fully established. To provide true cost effectiveness data, a comparative prospective study was initiated in patients with stage II and III pressure ulcers. Considering the potential impact of the pressure reduction mattress on clinical outcome, in particular, the same type of pressure reduction mattresses are utilized in all the cases in the study. The cost analysis method used was Activity-Based Costing, which measures material and labor cost aspects on a daily basis. A reduction in the Pressure Sore Status Tool (PSST) score was used to measure clinical effectiveness. Patients were divided into three groups based on the treatment method and on the use of a consistent algorithm of wound care: 1. MC/A group, modern dressings with a treatment algorithm (control cohort). 2. TC/A group, traditional care (ointment and gauze) with a treatment algorithm. 3. TC/NA group, traditional care (ointment and gauze) without a treatment algorithm. The results revealed that MC/A is more cost-effective than both TC/A and TC/NA. This suggests that appropriate utilization of modern dressing materials and a pressure ulcer care algorithm would contribute to reducing health care costs, improved clinical results, and, ultimately, greater cost-effectiveness.

  17. Unexpected Activity of a Novel Kunitz-type Inhibitor

    Science.gov (United States)

    Smith, David; Tikhonova, Irina G.; Jewhurst, Heather L.; Drysdale, Orla C.; Dvořák, Jan; Robinson, Mark W.; Cwiklinski, Krystyna; Dalton, John P.

    2016-01-01

    Kunitz-type (KT) protease inhibitors are low molecular weight proteins classically defined as serine protease inhibitors. We identified a novel secreted KT inhibitor associated with the gut and parenchymal tissues of the infective juvenile stage of Fasciola hepatica, a helminth parasite of medical and veterinary importance. Unexpectedly, recombinant KT inhibitor (rFhKT1) exhibited no inhibitory activity toward serine proteases but was a potent inhibitor of the major secreted cathepsin L cysteine proteases of F. hepatica, FhCL1 and FhCL2, and of human cathepsins L and K (Ki = 0.4-27 nm). FhKT1 prevented the auto-catalytic activation of FhCL1 and FhCL2 and formed stable complexes with the mature enzymes. Pulldown experiments from adult parasite culture medium showed that rFhKT1 interacts specifically with native secreted FhCL1, FhCL2, and FhCL5. Substitution of the unusual P1 Leu15 within the exposed reactive loop of FhKT1 for the more commonly found Arg (FhKT1Leu15/Arg15) had modest adverse effects on the cysteine protease inhibition but conferred potent activity against the serine protease trypsin (Ki = 1.5 nm). Computational docking and sequence analysis provided hypotheses for the exclusive binding of FhKT1 to cysteine proteases, the importance of the Leu15 in anchoring the inhibitor into the S2 active site pocket, and the inhibitor's selectivity toward FhCL1, FhCL2, and human cathepsins L and K. FhKT1 represents a novel evolutionary adaptation of KT protease inhibitors by F. hepatica, with its prime purpose likely in the regulation of the major parasite-secreted proteases and/or cathepsin L-like proteases of its host. PMID:27422822

  18. GPR surveying of transport infrastructures and buildings; underground utility and void sensing - ongoing activities in Working Group 2 of COST Action TU1208

    Science.gov (United States)

    Pajewski, Lara; Plati, Christina; Derobert, Xavier

    2015-04-01

    This work aims at presenting the ongoing research activities carried out in Working Group 2 'GPR surveying of pavements, bridges, tunnels and buildings; underground utility and void sensing' of the COST (European COoperation in Science and Technology) Action TU1208 'Civil Engineering Applications of Ground Penetrating Radar' (www.GPRadar.eu). The principal goal of the COST Action TU1208 is to exchange and increase scientific-technical knowledge and experience of Ground Penetrating Radar (GPR) techniques in civil engineering, whilst simultaneously promoting throughout Europe the effective use of this safe and non-destructive technique in the monitoring of infrastructures and structures. Four Working Groups (WGs) carry out the research activities. WG1 focuses on the development of innovative GPR equipment dedicated for civil engineering applications. WG2 deals with the development of guidelines and protocols for the surveying, through the use of a GPR system, of transport infrastructure and buildings, as well as for the sensing of utilities and voids. WG3 deals with the development of electromagnetic forward and inverse scattering methods, for the characterization of GPR scenarios, as well as with data- processing algorithms for the elaboration of the data collected during GPR surveys. WG4 is concerned with the use of GPR in fields different from the civil engineering, as well as with the integration of GPR with other non-destructive testing techniques. Each WG includes several Projects. WG2 includes five Projects. Project 2.1 focuses on outlining 'Innovative inspection procedures for effective GPR surveying of critical transport infrastructures (pavements, bridges and tunnels).' Project 2.2 is concerned with the development of 'Innovative inspection procedures for effective GPR surveying of buildings.' Project 2.3 deals with identifying 'Innovative inspection procedures for effective GPR sensing and mapping of underground utilities and voids, with a focus to urban

  19. Multiattribute Utility Theory without Expected Utility Foundations

    NARCIS (Netherlands)

    J. Miyamoto (John); P.P. Wakker (Peter)

    1996-01-01

    textabstractMethods for determining the form of utilities are needed for the implementation of utility theory in specific decisions. An important step forward was achieved when utility theorists characterized useful parametric families of utilities and simplifying decompositions of multiattribute ut

  20. N-methylpyridinium, a degradation product of trigonelline upon coffee roasting, stimulates respiratory activity and promotes glucose utilization in HepG2 cells.

    Science.gov (United States)

    Riedel, Annett; Hochkogler, Christina Maria; Lang, Roman; Bytof, Gerhard; Lantz, Ingo; Hofmann, Thomas; Somoza, Veronika

    2014-03-01

    N-Methylpyridinium (NMP) is a thermal degradation product of trigonelline formed upon coffee roasting and hypothesized to exert several health benefits in humans. Since for trigonelline evidence for hypoglycemic effects exists, we examined whether NMP also affects mechanisms of glucose utilization and cellular energy formation. For this purpose, the impact of trigonelline and NMP on respiratory activity, extracellular acidification, cellular adenosine nucleotides, energy supply from fatty acids and glucose as well as thermogenesis in HepG2 cells was analyzed. A 24 hour incubation with nanomolar concentrations of NMP enhanced oxygen consumption rates, resulting in increased ATP levels. Glucose was identified as the prevalent energy substrate as its uptake was augmented up to 18.1% ± 7.44% by NMP at 0.09 μM, whereas the uptake of fatty acids decreased upon NMP treatment. Cellular glucose uptake was also stimulated by trigonelline administration; however, a shift to the anaerobic energy production pathway was monitored. Both pyridine derivatives induced thermogenesis, although trigonelline presumably promoted proton leaks, while NMP increased the concentration of the uncoupling protein-2. We provide evidence that both compounds appear to stimulate cellular energy metabolism in HepG2 cells. Human intervention studies are warranted to ensure these effects in vivo.

  1. Distributed H2 Supply for Fuel Cell Utility Vehicles Year 6 - Activity 3.5 - Development fo a National Center for Hydrogen Technology

    Energy Technology Data Exchange (ETDEWEB)

    Almlie, Jay

    2012-04-15

    The Energy & Environmental Research Center (EERC) has developed a high-pressure hydrogen production system that reforms a liquid organic feedstock and water at operating pressures up to 800 bar (~12,000 psig). The advantages of this system include the elimination of energy-intensive hydrogen compression, a smaller process footprint, and the elimination of gaseous or liquid hydrogen transport. This system could also potentially enable distributed hydrogen production from centralized coal. Processes have been investigated to gasify coal and then convert the syngas into alcohol or alkanes. These alcohols and alkanes could then be easily transported in bulk to distributed high-pressure water-reforming (HPWR)-based systems to deliver hydrogen economically. The intent of this activity was to utilize the EERC’s existing HPWR hydrogen production process, previously designed and constructed in a prior project phase, as a basis to improve operational and production performance of an existing demonstration unit. Parameters to be pursued included higher hydrogen delivery pressure, higher hydrogen production rates, and the ability to refill within a 5-minute time frame.

  2. Aerobic production and utilization of lactate satisfy increased energy demands upon neuronal activation in hippocampal slices and provide neuroprotection against oxidative stress

    Directory of Open Access Journals (Sweden)

    Avital eSchurr

    2012-01-01

    Full Text Available Ever since it was shown for the first time that lactate can support neuronal function in vitro as a sole oxidative energy substrate, investigators in the field of neuroenergetics have been debating the role, if any, of this glycolytic product in cerebral energy metabolism. Our experiments employed the rat hippocampal slice preparation with electrophysiological and biochemical methodologies. The data generated by these experiments a support the hypothesis that lactate, not pyruvate, is the end product of cerebral aerobic glycolysis; b indicate that lactate plays a major and crucial role in affording neural tissue to respond adequately to glutamate excitation and to recover unscathed post-excitation; c suggest that neural tissue activation is accompanied by aerobic lactate and NADH production, the latter being produced when the former is converted to pyruvate by mitochondrial lactate dehydrogenase (mLDH; d imply that NADH can be utilized as an endogenous scavenger of reactive oxygen species (ROS to provide neuroprotection against ROS-induced neuronal damage.

  3. Maximizing the utilization of Laminaria japonica as biomass via improvement of alginate lyase activity in a two-phase fermentation system.

    Science.gov (United States)

    Oh, Yuri; Xu, Xu; Kim, Ji Young; Park, Jong Moon

    2015-08-01

    Brown seaweed contains up to 67% of carbohydrates by dry weight and presents high potential as a polysaccharide feedstock for biofuel production. To effectively use brown seaweed as a biomass, degradation of alginate is the major challenge due to its complicated structure and low solubility in water. This study focuses on the isolation of alginate degrading bacteria, determining of the optimum fermentation conditions, as well as comparing the conventional single fermentation system with the two-phase fermentation system which is separately using alginate and mannitol extracted from Laminaria japonica. Maximum yield of organic acids production and volatile solids reduction obtained were 0.516 g/g and 79.7%, respectively, using the two-phase fermentation system in which alginate fermentation was carried out at pH 7 and mannitol fermentation at pH 8. The two-phase fermentation system increased the yield of organic acids production by 1.14 times and led to a 1.45-times reduction of VS when compared to the conventional single fermentation system at pH 8. The results show that the two-phase fermentation system improved the utilization of alginate by separating alginate from mannitol leading to enhanced alginate lyase activity.

  4. γ-Glutamyltransferases (GGT) in Colletotrichum graminicola: mRNA and enzyme activity, and evidence that CgGGT1 allows glutathione utilization during nitrogen deficiency.

    Science.gov (United States)

    Bello, Marco H; Morin, Dexter; Epstein, Lynn

    2013-02-01

    Gamma-glutamyltransferase (GGT, EC 2.3.2.2) cleaves the γ-glutamyl linkage in glutathione (GSH). Three GGTs in the hemibiotrophic plant pathogen Colletotrichum graminicola were identified in silico. GGT mRNA expression was monitored by quantitative reverse-transcriptase PCR. Expression of all three genes was detected in planta during the biotrophic and necrotrophic stages of infection. Of the three GGTs, CgGGT1 mRNA (from gene GLRG_09590) was the most highly expressed. All three GGT mRNAs were up-regulated in wild type nitrogen-starved germlings in comparison to non-starved germlings. CgGGT1 was insertionally mutagenized in C. graminicola, complemented with the wild type form of the gene, and over-expressed. Enzyme assays of two independent CgGGT1 knockouts and the wild type indicated that CgGGT1 is the major GGT and accounts for 86% and 68% of total GGT activity in conidia and mycelia, respectively. The over-expressing strain had 8-fold and 3-fold more enzyme activity in conidia and mycelia, respectively, than the wild type. In an analysis of the GGT knockout, complemented and over-expressing strains, GGT1 transcript levels are highly correlated (r=0.95) with levels of total GGT enzyme activity. CgGGT1 and CgGGT2 genes in strains that had ectopic copies of CgGGT1 were not up-regulated by nitrogen-starvation, in contrast to the wild type. Deletion or over-expression of CgGGT1 had no effect on mRNA expression of CgGGT2 and CgGGT3. In broth in which 3 and 6mM glutathione (GSH) was the nitrogen source, the CgGGT1 over-expressing strain produced significantly (P<0.0001) more biomass than the wild type and complemented strains, whereas the CgGGT1Δ strains produced significantly (P<0.0001) less biomass than the wild type strain. This suggests that CgGGT1 is involved in utilizing GSH as a nitrogen source. However, deletion and over-expression of CgGGT1 had no effect on either virulence in wounded corn leaf sheaths or GSH levels in conidia and mycelia. Thus, the

  5. Cost-effectiveness and cost-utility of a Web-based or print-delivered tailored intervention to promote physical activity among adults aged over fifty: an economic evaluation of the Active Plus intervention.

    Science.gov (United States)

    Golsteijn, Rianne Hj; Peels, Denise A; Evers, Silvia Maa; Bolman, Catherine; Mudde, Aart N; de Vries, Hein; Lechner, Lilian

    2014-09-28

    The adverse health effects of insufficient physical activity (PA) result in high costs to society. The economic burden of insufficient PA, which increases in our aging population, stresses the urgency for cost-effective interventions to promote PA among older adults. The current study provides insight in the cost-effectiveness and cost-utility of different versions of a tailored PA intervention (Active Plus) among adults aged over fifty. The intervention conditions (i.e. print-delivered basic (PB; N = 439), print-delivered environmental (PE; N = 435), Web-based basic (WB; N = 423), Web-based environmental (WE; N = 432)) and a waiting-list control group were studied in a clustered randomized controlled trial. Intervention costs were registered during the trial. Health care costs, participant costs and productivity losses were identified and compared with the intervention effects on PA (in MET-hours per week) and quality-adjusted life years (QALYs) 12 months after the start of the intervention. Cost-effectiveness ratios (ICERs) and cost-utility ratios (ICURs) were calculated per intervention condition. Non-parametric bootstrapping techniques and sensitivity analyses were performed to account for uncertainty. As a whole (i.e. the four intervention conditions together) the Active Plus intervention was found to be cost-effective. The PB-intervention (ICER = €-55/MET-hour), PE-intervention (ICER = €-94/MET-hour) and the WE-intervention (ICER = €-139/MET-hour) all resulted in higher effects on PA and lower societal costs than the control group. With regard to QALYs, the PB-intervention (ICUR = €38,120/QALY), the PE-intervention (ICUR = €405,892/QALY) and the WE-intervention (ICUR = €-47,293/QALY) were found to be cost-effective when considering a willingness-to-pay threshold of €20,000/QALY. In most cases PE had the highest probability to be cost-effective. The Active Plus intervention was found to be a cost

  6. Identifying low pH active and lactate-utilizing taxa within oral microbiome communities from healthy children using stable isotope probing techniques.

    Directory of Open Access Journals (Sweden)

    Jeffrey S McLean

    Full Text Available BACKGROUND: Many human microbial infectious diseases including dental caries are polymicrobial in nature. How these complex multi-species communities evolve from a healthy to a diseased state is not well understood. Although many health- or disease-associated oral bacteria have been characterized in vitro, their physiology within the complex oral microbiome is difficult to determine with current approaches. In addition, about half of these species remain uncultivated to date with little known besides their 16S rRNA sequence. Lacking culture-based physiological analyses, the functional roles of uncultivated species will remain enigmatic despite their apparent disease correlation. To start addressing these knowledge gaps, we applied a combination of Magnetic Resonance Spectroscopy (MRS with RNA and DNA based Stable Isotope Probing (SIP to oral plaque communities from healthy children for in vitro temporal monitoring of metabolites and identification of metabolically active and inactive bacterial species. METHODOLOGY/PRINCIPAL FINDINGS: Supragingival plaque samples from caries-free children incubated with (13C-substrates under imposed healthy (buffered, pH 7 and diseased states (pH 5.5 and pH 4.5 produced lactate as the dominant organic acid from glucose metabolism. Rapid lactate utilization upon glucose depletion was observed under pH 7 conditions. SIP analyses revealed a number of genera containing cultured and uncultivated taxa with metabolic capabilities at pH 5.5. The diversity of active species decreased significantly at pH 4.5 and was dominated by Lactobacillus and Propionibacterium species, both of which have been previously found within carious lesions from children. CONCLUSIONS/SIGNIFICANCE: Our approach allowed for identification of species that metabolize carbohydrates under different pH conditions and supports the importance of Lactobacilli and Propionibacterium in the development of childhood caries. Identification of species within

  7. Regulation of Lactobacillus casei Sorbitol Utilization Genes Requires DNA-Binding Transcriptional Activator GutR and the Conserved Protein GutM▿

    Science.gov (United States)

    Alcántara, Cristina; Sarmiento-Rubiano, Luz Adriana; Monedero, Vicente; Deutscher, Josef; Pérez-Martínez, Gaspar; Yebra, María J.

    2008-01-01

    Sequence analysis of the five genes (gutRMCBA) downstream from the previously described sorbitol-6-phosphate dehydrogenase-encoding Lactobacillus casei gutF gene revealed that they constitute a sorbitol (glucitol) utilization operon. The gutRM genes encode putative regulators, while the gutCBA genes encode the EIIC, EIIBC, and EIIA proteins of a phosphoenolpyruvate-dependent sorbitol phosphotransferase system (PTSGut). The gut operon is transcribed as a polycistronic gutFRMCBA messenger, the expression of which is induced by sorbitol and repressed by glucose. gutR encodes a transcriptional regulator with two PTS-regulated domains, a galactitol-specific EIIB-like domain (EIIBGat domain) and a mannitol/fructose-specific EIIA-like domain (EIIAMtl domain). Its inactivation abolished gut operon transcription and sorbitol uptake, indicating that it acts as a transcriptional activator. In contrast, cells carrying a gutB mutation expressed the gut operon constitutively, but they failed to transport sorbitol, indicating that EIIBCGut negatively regulates GutR. A footprint analysis showed that GutR binds to a 35-bp sequence upstream from the gut promoter. A sequence comparison with the presumed promoter region of gut operons from various firmicutes revealed a GutR consensus motif that includes an inverted repeat. The regulation mechanism of the L. casei gut operon is therefore likely to be operative in other firmicutes. Finally, gutM codes for a conserved protein of unknown function present in all sequenced gut operons. A gutM mutant, the first constructed in a firmicute, showed drastically reduced gut operon expression and sorbitol uptake, indicating a regulatory role also for GutM. PMID:18676710

  8. Cost-utility analysis of certolizumab pegol versus alternative tumour necrosis factor inhibitors available for the treatment of moderate-to-severe active rheumatoid arthritis in Spain

    OpenAIRE

    2015-01-01

    Background Certolizumab pegol, a PEGylated tumour necrosis factor (TNF)-inhibitor, improves the clinical signs and symptoms of rheumatoid arthritis (RA) when used in combination with methotrexate or as monotherapy. This study evaluatedthe cost-utility of certolizumab pegol versusTNF-inhibitors plus methotrexate in the treatment of moderate-to-severe RA in Spain. Methods A Markov cohort health state transition model was developed to evaluate the cost-utility (costs and quality-adjusted life ye...

  9. Module Utilization Committee. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1984-03-01

    Photovoltaic collector modules were declared surplus to the needs of the US Department of Energy. The Module Utilization Committee was formed to make appropriate disposition of the surplus modules. The final report of that committee accounts for that disposition. The membership and activities of the committee are set forth and the results of its activities are reported.

  10. The role of extracellular carbonic anhydrase activity in inorganic carbon utilization of Phaeocystis globosa (Prymnesiophyceae) : A comparison with other marine algae using the isotopic disequilibrium technique

    NARCIS (Netherlands)

    Elzenga, JTM; Prins, HBA; Stefels, J

    2000-01-01

    The utilization of inorganic carbon species by the marine microalga Phaeocystis globasa (Prymnesiophyceae) and several other algal species from different taxa, was investigated by determining the time course of C-14 incorporation in isotopic disequilibrium experiments. From these kinetic data, concl

  11. 北虫草的活性成分及开发利用研究%Study on the Active Components and Utilization of Cordyceps Militaris

    Institute of Scientific and Technical Information of China (English)

    叶春苗

    2014-01-01

    Much research and attention have been devoted to Cordyceps militaris due to its medicinal and health functions. This article makes summary of the main bioactive components in Cordyceps militaris and its development and utilization, gives a description of the artificial cultivation method of Cordyceps militaris, and analyzes its exploitation and utilization prospect so as to provide reference for the further research and use of Cordyceps militaris.%北虫草因具有药用与保健功能,被广泛研究与关注。综述北虫草中主要生物活性成分及其开发利用情况,介绍北虫草的人工培育方法,分析、展望北虫草的开发利用前景,以期为北虫草的进一步研究、利用提供参考。

  12. The U.S. power industry's activities to expand coal ash utilization in face of lower ash quality

    Energy Technology Data Exchange (ETDEWEB)

    Golden, D.M. [Electric Power Research Inst., Palo Alto, CA (United States)

    2001-07-01

    The use of coal by electric power utilities results in more than 105 million tons of by products each year in the United States. More restrictive air quality emission limits have resulted in cleaner air, but this means the fly ash is more contaminated and cannot be used in its largest market, the concrete industry. For this reason, the Electric Power Research Institute (EPRI) conducted a 5 year program at increasing ash utilization in the cement and concrete market in the United States. This initiative was in response to recent concerns regarding the impacts on ash quality due to more aggressive nitrogen oxide (NOx) controls. The EPRI program provides the technical basis for protecting the bulk sale of coal ash in high-volume applications in cement and concrete and other high volume civil engineering applications. Fly ash derived from NOx control systems has higher carbon levels and ammonia levels. Problems with ammoniated ash are a major concern for coal-fired power plants. It was shown that there are four ways to minimize the impact of NOx controls that reduce ash quality directly affecting ash utilization. These are: (1) prevention of carbon accumulation in fly ash for use in sensitive markets, (2) carbon removal, (3) concentration of reactive ash fractions by removal of coarse fractions, and (4) ammonia removal. It was concluded that more studies are needed to examine long-term durability and other properties before any of these options can be exploited on an industrial scale. 21 refs., 1 tab.

  13. Utility usage forecasting

    Energy Technology Data Exchange (ETDEWEB)

    Hosking, Jonathan R. M.; Natarajan, Ramesh

    2017-08-22

    The computer creates a utility demand forecast model for weather parameters by receiving a plurality of utility parameter values, wherein each received utility parameter value corresponds to a weather parameter value. Determining that a range of weather parameter values lacks a sufficient amount of corresponding received utility parameter values. Determining one or more utility parameter values that corresponds to the range of weather parameter values. Creating a model which correlates the received and the determined utility parameter values with the corresponding weather parameters values.

  14. Utilization of contraception among sexually active HIV positive women attending art clinic in University of Gondar Hospital: a hospital based cross-sectional study.

    Science.gov (United States)

    Worke, Mulugeta Dile; Bezabih, Lealem Meseret; Woldetasdik, Mulat Adefris

    2016-10-21

    Contraception helps to prevent unplanned pregnancies among human immune virus positive women. The contraceptive utilization status and associated factors were not well addressed in the study area. Therefore, this study aimed to assess utilization of contraceptives and associated factors among human immune virus positive reproductive age group women appearing at anti-retroviral therapy clinic at the University of Gondar Hospital, North West Ethiopia. An institution based cross-sectional study was conducted among 397 systematically selected HIV positive reproductive age women who visited ART unit of the University of Gondar teaching referral hospital from January 8-20, 2014. The data were collected using pre tested and structured questionnaires through face-to-face interviews. The data were entered into Epi-Info version 3.5, and cleaned and analyzed using SPSS version 20. Descriptive summary of the data and logistic regression were used to identify possible predictors using odds ratio with 95 % confidence interval and P-value of 0.05. The study revealed that the overall utilization of any type of contraception was 50 %. Of them, 4.1 % got contraception from anti-retroviral therapy unit. Fear of side effects was the most common (42 %) reason for not using contraception. Women who attended secondary education, married and who had 4-6 children were more likely to use contraception than their counterparts were; (AOR: 5.63; 95 % CI: 1.74-18.21), (AOR: 8.07; 95 % CI: 3.10-20.99) and (AOR: 3.61; 95 % CI: 1.16-11.26) respectively. However, Women between 35-49 years, had no intention to have another child and discordant couples were 83 %, 76 % and 65 % less likely to use contraception respectively than their counterparts. The results of this study revealed that the utilization of contraception was low. Women between 35-49 years, those who had no intention to have another child and whose partner was HIV sero-negative and fear of side effect of the contraception

  15. Entrez Programming Utilities

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Entrez Programming Utilities (E-utilities) are a set of eight server-side programs that provide a stable interface into the Entrez query and database system at...

  16. Peroxisome Proliferator-Activated Receptor-alpha-Null Mice Have Increased White Adipose Tissue Glucose Utilization, GLUT4, and Fat Mass: Role in Liver and Brain

    NARCIS (Netherlands)

    Knauf, C.; Rieusset, J.; Foretz, M.; Cani, P.D.; Uldry, M.; Hosokawa, M.; Martinez, E.; Bringart, M.; Waget, A.; Kersten, A.H.; Desvergne, B.; Gremlich, S.; Wahli, W.; Seydoux, J.; Delzenne, N.M.; Thorens, B.; Burcelin, R.

    2006-01-01

    Activation of the peroxisome proliferator-activated receptor (PPAR)-¿ increases lipid catabolism and lowers the concentration of circulating lipid, but its role in the control of glucose metabolism is not as clearly established. Here we compared PPAR¿ knockout mice with wild type and confirmed that

  17. Peroxisome Proliferator-Activated Receptor-alpha-Null Mice Have Increased White Adipose Tissue Glucose Utilization, GLUT4, and Fat Mass: Role in Liver and Brain

    NARCIS (Netherlands)

    Knauf, C.; Rieusset, J.; Foretz, M.; Cani, P.D.; Uldry, M.; Hosokawa, M.; Martinez, E.; Bringart, M.; Waget, A.; Kersten, A.H.; Desvergne, B.; Gremlich, S.; Wahli, W.; Seydoux, J.; Delzenne, N.M.; Thorens, B.; Burcelin, R.

    2006-01-01

    Activation of the peroxisome proliferator-activated receptor (PPAR)-¿ increases lipid catabolism and lowers the concentration of circulating lipid, but its role in the control of glucose metabolism is not as clearly established. Here we compared PPAR¿ knockout mice with wild type and confirmed that

  18. Nonexpected utility and coherence

    NARCIS (Netherlands)

    Diecidue, E.

    2001-01-01

    The descriptive power of expected utility has been challenged by behavioral evidence showing that people deviate systematically from the expected utility paradigm. Since the end of the 70's several alternatives to the classical expected utility paradigm have been proposed in order to accommodate the

  19. Information, evolution and utility

    Directory of Open Access Journals (Sweden)

    Larry Samuelson

    2006-03-01

    Full Text Available Human utility embodies a number of seemingly irrational aspects. The leading example in this paper is that utilities often depend on the presence of salient unchosen alternatives. Our focus is to understand why an evolutionary process might optimally lead to such seemingly dysfunctional features in our motivations and to derive implications for the nature of our utility functions.

  20. Utility of N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides as precursors for synthesis of new functionalized 1,3,4-thiadiazoles with potential antimicrobial activity

    Directory of Open Access Journals (Sweden)

    Abdou O. Abdelhamid

    2015-11-01

    Full Text Available Starting from N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides, a series of new functionalized 1,3,4-thiadiazoles were prepared. The structures of the compounds prepared were confirmed by both elemental and spectral analyses as well as by alternate synthesis. The mechanisms of the studied reactions are outlined. The antimicrobial activities of the compounds prepared were screened and the results showed that most of such compounds exhibit considerable activities.

  1. Automated ISS Flight Utilities

    Science.gov (United States)

    Offermann, Jan Tuzlic

    2016-01-01

    During my internship at NASA Johnson Space Center, I worked in the Space Radiation Analysis Group (SRAG), where I was tasked with a number of projects focused on the automation of tasks and activities related to the operation of the International Space Station (ISS). As I worked on a number of projects, I have written short sections below to give a description for each, followed by more general remarks on the internship experience. My first project is titled "General Exposure Representation EVADOSE", also known as "GEnEVADOSE". This project involved the design and development of a C++/ ROOT framework focused on radiation exposure for extravehicular activity (EVA) planning for the ISS. The utility helps mission managers plan EVAs by displaying information on the cumulative radiation doses that crew will receive during an EVA as a function of the egress time and duration of the activity. SRAG uses a utility called EVADOSE, employing a model of the space radiation environment in low Earth orbit to predict these doses, as while outside the ISS the astronauts will have less shielding from charged particles such as electrons and protons. However, EVADOSE output is cumbersome to work with, and prior to GEnEVADOSE, querying data and producing graphs of ISS trajectories and cumulative doses versus egress time required manual work in Microsoft Excel. GEnEVADOSE automates all this work, reading in EVADOSE output file(s) along with a plaintext file input by the user providing input parameters. GEnEVADOSE will output a text file containing all the necessary dosimetry for each proposed EVA egress time, for each specified EVADOSE file. It also plots cumulative dose versus egress time and the ISS trajectory, and displays all of this information in an auto-generated presentation made in LaTeX. New features have also been added, such as best-case scenarios (egress times corresponding to the least dose), interpolated curves for trajectories, and the ability to query any time in the

  2. Utilizing peroxide as precursor for the synthesis of CeO{sub 2}/ZnO composite oxide with enhanced photocatalytic activity

    Energy Technology Data Exchange (ETDEWEB)

    Lv, Zijian [School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094 (China); Nanjing AIREP Environmental Protection Technology Co., Ltd, Nanjing, Jiangsu 210091 (China); Zhong, Qin, E-mail: zq304@mail.njust.edu.com.cn [School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094 (China); Nanjing AIREP Environmental Protection Technology Co., Ltd, Nanjing, Jiangsu 210091 (China); Ou, Man [School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094 (China); Nanjing AIREP Environmental Protection Technology Co., Ltd, Nanjing, Jiangsu 210091 (China)

    2016-07-15

    Graphical abstract: - Highlights: • The CeO2/ZnO composite oxide is synthesized with peroxide as a precursor. • The excellent photocatalytic activity is due to the synergistic effect of CeO2 and oxygen vacancy. • The hydroxyl radicals are confirmed to be the dominant active species. - Abstract: A facile synthesis method of CeO{sub 2}/ZnO composite oxides with higher oxygen vacancy concentration was developed by a two-step precipitation method, in which peroxide was used as precursor. The photocatalytic activity of the catalysts under UV irradiation was studied in degradation of methylene blue (MB). All CeO{sub 2}/ZnO photocatalysts exhibited higher photocatalytic performance than pure ZnO, and 1%CeO{sub 2}/ZnO showed highest photocatalytic activity among the prepared catalysts. It was confirmed that the synergistic effect of CeO{sub 2} and oxygen vacancy caused the improved photocatalytic activity. Furthermore, the mechanism was investigated by introducing different additives, and it was found that the hydroxyl radicals played a crucial role in degradation process.

  3. Optimization of 1,2,3,4-tetrahydroacridin-9(10H)-ones as antimalarials utilizing structure-activity and structure-property relationships.

    Science.gov (United States)

    Cross, R Matthew; Maignan, Jordany R; Mutka, Tina S; Luong, Lisa; Sargent, Justin; Kyle, Dennis E; Manetsch, Roman

    2011-07-14

    Antimalarial activity of 1,2,3,4-tetrahydroacridin-9(10H)-ones (THAs) has been known since the 1940s and has garnered more attention with the development of the acridinedione floxacrine (1) in the 1970s and analogues thereof such as WR 243251 (2a) in the 1990s. These compounds failed just prior to clinical development because of suboptimal activity, poor solubility, and rapid induction of parasite resistance. Moreover, detailed structure-activity relationship (SAR) studies of the THA core scaffold were lacking and SPR studies were nonexistent. To improve upon initial findings, several series of 1,2,3,4-tetrahydroacridin-9(10H)-ones were synthesized and tested in a systematic fashion, examining each compound for antimalarial activity, solubility, and permeability. Furthermore, a select set of compounds was chosen for microsomal stability testing to identify physicochemical liabilities of the THA scaffold. Several potent compounds (EC(50) < 100 nM) were identified to be active against the clinically relevant isolates W2 and TM90-C2B while possessing good physicochemical properties and little to no cross-resistance.

  4. TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.

    Science.gov (United States)

    Vassilev, A; Kaneko, K J; Shu, H; Zhao, Y; DePamphilis, M L

    2001-05-15

    Mammals express four highly conserved TEAD/TEF transcription factors that bind the same DNA sequence, but serve different functions during development. TEAD-2/TEF-4 protein purified from mouse cells was associated predominantly with a novel TEAD-binding domain at the amino terminus of YAP65, a powerful transcriptional coactivator. YAP65 interacted specifically with the carboxyl terminus of all four TEAD proteins. Both this interaction and sequence-specific DNA binding by TEAD were required for transcriptional activation in mouse cells. Expression of YAP in lymphocytic cells that normally do not support TEAD-dependent transcription (e.g., MPC11) resulted in up to 300-fold induction of TEAD activity. Conversely, TEAD overexpression squelched YAP activity. Therefore, the carboxy-terminal acidic activation domain in YAP is the transcriptional activation domain for TEAD transcription factors. However, whereas TEAD was concentrated in the nucleus, excess YAP65 accumulated in the cytoplasm as a complex with the cytoplasmic localization protein, 14-3-3. Because TEAD-dependent transcription was limited by YAP65, and YAP65 also binds Src/Yes protein tyrosine kinases, we propose that YAP65 regulates TEAD-dependent transcription in response to mitogenic signals.

  5. Teacher Didactic Content Knowledge and its relation with the utilization of practical activities in chemistry classes: A study with expert teachers of the Angolan educational system

    Directory of Open Access Journals (Sweden)

    Laurinda Baca

    2014-03-01

    Full Text Available This study was developed within the Angolan educational system, with chemistry expert teachers who teach the 7th grade (12 years old. Aiming to characterize the didactic content knowledge and relate it with the quality of teaching and with the development of practical activities that ensure the active participation of students in the construction of knowledge, we observed and analyzed the classes of a group of expert teachers, specifically in the content of chemical reactions and chemical equations. In a quasi-experimental design methodology, the used technique was the observation from the capture of images in the classes. An element we paid particular attention in the analysis of the classes was the implementation of strategies that involve practical activities, since the didactic research has amply demonstrated that they are likely to generate active learning in science education, with particular emphasis in chemistry. The results revealed that the expert teachers often use practical activities in their classrooms, using group work procedures, work front and questions oral and written.

  6. Utilizing peroxide as precursor for the synthesis of CeO2/ZnO composite oxide with enhanced photocatalytic activity

    Science.gov (United States)

    Lv, Zijian; Zhong, Qin; Ou, Man

    2016-07-01

    A facile synthesis method of CeO2/ZnO composite oxides with higher oxygen vacancy concentration was developed by a two-step precipitation method, in which peroxide was used as precursor. The photocatalytic activity of the catalysts under UV irradiation was studied in degradation of methylene blue (MB). All CeO2/ZnO photocatalysts exhibited higher photocatalytic performance than pure ZnO, and 1%CeO2/ZnO showed highest photocatalytic activity among the prepared catalysts. It was confirmed that the synergistic effect of CeO2 and oxygen vacancy caused the improved photocatalytic activity. Furthermore, the mechanism was investigated by introducing different additives, and it was found that the hydroxyl radicals played a crucial role in degradation process.

  7. X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design

    Science.gov (United States)

    Clasman, Jozlyn R.; Báez-Santos, Yahira M.; Mettelman, Robert C.; O’Brien, Amornrat; Baker, Susan C.; Mesecar, Andrew D.

    2017-01-01

    Ubiquitin-like domain 2 (Ubl2) is immediately adjacent to the N-terminus of the papain-like protease (PLpro) domain in coronavirus polyproteins, and it may play a critical role in protease regulation and stability as well as in viral infection. However, our recent cellular studies reveal that removing the Ubl2 domain from MERS PLpro has no effect on its ability to process the viral polyprotein or act as an interferon antagonist, which involves deubiquitinating and deISGylating cellular proteins. Here, we test the hypothesis that the Ubl2 domain is not required for the catalytic function of MERS PLpro in vitro. The X-ray structure of MERS PLpro-∆Ubl2 was determined to 1.9 Å and compared to PLpro containing the N-terminal Ubl2 domain. While the structures were nearly identical, the PLpro-∆Ubl2 enzyme revealed the intact structure of the substrate-binding loop. Moreover, PLpro-∆Ubl2 catalysis against different substrates and a purported inhibitor revealed no differences in catalytic efficiency, substrate specificity, and inhibition. Further, no changes in thermal stability were observed between enzymes. We conclude that the catalytic core of MERS PLpro, i.e. without the Ubl2 domain, is sufficient for catalysis and stability in vitro with utility to evaluate potential inhibitors as a platform for structure-based drug design. PMID:28079137

  8. Trm1p, a Zn(II)₂Cys₆-type transcription factor, is essential for the transcriptional activation of genes of methanol utilization pathway, in Pichia pastoris.

    Science.gov (United States)

    Sahu, Umakant; Krishna Rao, Kamisetty; Rangarajan, Pundi N

    2014-08-15

    The zinc finger transcription factors Mxr1p and Rop are key regulators of methanol metabolism in the methylotrophic yeast, Pichia pastoris, while Trm1p and Trm2p regulate methanol metabolism in Candida boidinii. Here, we demonstrate that Trm1p is essential for the expression of genes of methanol utilization (mut) pathway in P. pastoris as well. Expression of AOXI and other genes of mut pathway is severely compromised in P. pastoris ΔTrm1 strain resulting in impaired growth on media containing methanol as the sole source of carbon. Trm1p localizes to the nucleus of cells cultured on glucose or methanol. The zinc finger domain of Mxr1p but not Trm1p binds to AOXI promoter sequences in vitro, indicating that these two positive regulators act by different mechanisms. We conclude that both Trm1p and Mxr1p are essential for the expression of genes of mut pathway in P. pastoris and the mechanism of transcriptional regulation of mut pathway may be similar in P. pastoris and C. boidinii.

  9. An Analysis of Success Factors in the Utilization of Learning Activity Packages Employed as Vehicles for Individualizing Science Instruction at Nova High School.

    Science.gov (United States)

    Campbell, Roy Franklin

    The purpose of this study was to determine whether "Learning Activity Packages" (LAPs) could be used as the basic instructional material of individualized instruction for certain types of students and not for others. A sample of 133 biology students was selected at random and assigned to one of three groups, low, medium or high, on the basis of…

  10. Utilizing Model Eliciting Activities (MEA's) to engage middle school teachers and students in storm water management practices to mitigate human impacts of land development

    Science.gov (United States)

    Tazaz, A.; Wilson, R. M.; Schoen, R.; Blumsack, S.; King, L.; Dyehouse, M.

    2013-12-01

    'The Integrating STEM Project' engaged 6-8 grade teachers through activities incorporating mathematics, science and technology incorporating both Next Generation Science Standards (NGSS) and Common Core State Standards-Mathematics (CCSS-Math). A group of researchers from Oceanography, Mathematics, and Education set out to provide middle school teachers with a 2 year intensive STEM integration professional development with a focus on environmental topics and to monitor the achievement outcomes in their students. Over the course of 2 years the researchers created challenging professional development sessions to expand teacher knowledge and teachers were tasked to transform the information gained during the professional development sessions for classroom use. One lesson resource kit presented to the teachers, which was directly applicable to the classroom, included Model Eliciting Activities (MEA's) to explore the positive and negative effects land development has on climate and the environment, and how land development impacts storm water management. MEA's were developed to encourage students to create models to solve complex problems and to allow teachers to investigate students thinking. MEA's are a great curriculum technique used in engineering fields to help engage students by providing hands on activities using real world data and problems. We wish to present the Storm Water Management Resource toolkit including the MEA and present the outcomes observed from student engagement in this activity.

  11. Industrial design of enzymic processes catalysed by very active immobilized derivatives: utilization of diffusional limitations (gradients of pH) as a profitable tool in enzyme engineering.

    Science.gov (United States)

    Guisán, J M; Alvaro, G; Rosell, C M; Fernandez-Lafuente, R

    1994-12-01

    We have developed integrated studies of enzyme reaction engineering for the hydrolysis of penicillin G catalysed by very active penicillin G acylase (PGA) derivatives. We have studied the distinct effect of a key variable (pH) on different industrial parameters (e.g. activity/stability parameters). In this way we have demonstrated, in contrast with that proposed by other authors, that the generation of gradients of pH inside the porous structure of very active enzyme derivatives may be not a problem but a 'very profitable tool' to improve the whole set of industrial parameters. In this way we can establish two distinct 'optimal pH values': (i) the one inside the particle of the biocatalyst and (ii) the one in the bulk solution. The use of an external pH of 8.0 associated with the promotion of a controlled decrease in internal pH (e.g. around a mean value of 5.5) was very useful to simultaneously obtain interesting values of all industrial parameters: (i) very high hydrolytic yields (higher than 97%); (ii) a very important increase on the stability of PGA derivatives (higher than a 50-fold factor); and (iii) a very small decrease in operational activity (approximately 15%) as compared with the one of soluble enzyme at pH 8.0 with no diffusional hindrances.

  12. Cost-utility of metal-on-metal hip resurfacing compared to conventional total hip replacement in young active patients with osteoarthritis

    NARCIS (Netherlands)

    Heintzbergen, S.; Kulin, N.A.; IJzerman, M.J.; Steuten, L.M.G.; Werle, J.; Khong, H.; Marshall, D.A.

    2013-01-01

    Background: Metal-on-metal hip resurfacing arthroplasty (MoM HRA) has emerged as an alternative to total hip arthroplasty (THA) for younger active patients with osteoarthritis (OA). Birmingham hip resurfacing is the most common MoM HRA in Alberta, and is therefore compared with conventional THA. Obj

  13. Increased Na+/K(+)-pump activity and adenosine triphosphate utilization after compound 48/80-induced histamine secretion from rat mast cells

    DEFF Research Database (Denmark)

    Johansen, Torben; Praetorius, Birger Hans

    1994-01-01

    -production were measured by the bioluminescence technique (firefly lantern) and by measurement of the lactate production under anaerobic conditions (antimycin A, oligomycin), respectively. There was an increased requirement for ATP after the secretory response associated with an increased activity of the Na...

  14. Quantitative determination of biological activity of botulinum toxins utilizing compound muscle action potentials (CMAP), and comparison of neuromuscular transmission blockage and muscle flaccidity among toxins.

    Science.gov (United States)

    Torii, Yasushi; Goto, Yoshitaka; Takahashi, Motohide; Ishida, Setsuji; Harakawa, Tetsuhiro; Sakamoto, Takashi; Kaji, Ryuji; Kozaki, Shunji; Ginnaga, Akihiro

    2010-01-01

    The biological activity of various types of botulinum toxin has been evaluated using the mouse intraperitoneal LD(50) test (ip LD(50)). This method requires a large number of mice to precisely determine toxin activity, and so has posed a problem with regard to animal welfare. We have used a direct measure of neuromuscular transmission, the compound muscle action potential (CMAP), to evaluate the effect of different types of botulinum neurotoxin (NTX), and we compared the effects of these toxins to evaluate muscle relaxation by employing the digit abduction scoring (DAS) assay. This method can be used to measure a broad range of toxin activities the day after administration. Types A, C, C/D, and E NTX reduced the CMAP amplitude one day after administration at below 1 ip LD(50), an effect that cannot be detected using the mouse ip LD(50) assay. The method is useful not only for measuring toxin activity, but also for evaluating the characteristics of different types of NTX. The rat CMAP test is straightforward, highly reproducible, and can directly determine the efficacy of toxin preparations through their inhibition of neuromuscular transmission. Thus, this method may be suitable for pharmacology studies and the quality control of toxin preparations.

  15. YEAR 2 BIOMASS UTILIZATION

    Energy Technology Data Exchange (ETDEWEB)

    Christopher J. Zygarlicke

    2004-11-01

    This Energy & Environmental Research Center (EERC) Year 2 Biomass Utilization Final Technical Report summarizes multiple projects in biopower or bioenergy, transportation biofuels, and bioproducts. A prototype of a novel advanced power system, termed the high-temperature air furnace (HITAF), was tested for performance while converting biomass and coal blends to energy. Three biomass fuels--wood residue or hog fuel, corn stover, and switchgrass--and Wyoming subbituminous coal were acquired for combustion tests in the 3-million-Btu/hr system. Blend levels were 20% biomass--80% coal on a heat basis. Hog fuel was prepared for the upcoming combustion test by air-drying and processing through a hammer mill and screen. A K-Tron biomass feeder capable of operating in both gravimetric and volumetric modes was selected as the HITAF feed system. Two oxide dispersion-strengthened (ODS) alloys that would be used in the HITAF high-temperature heat exchanger were tested for slag corrosion rates. An alumina layer formed on one particular alloy, which was more corrosion-resistant than a chromia layer that formed on the other alloy. Research activities were completed in the development of an atmospheric pressure, fluidized-bed pyrolysis-type system called the controlled spontaneous reactor (CSR), which is used to process and condition biomass. Tree trimmings were physically and chemically altered by the CSR process, resulting in a fuel that was very suitable for feeding into a coal combustion or gasification system with little or no feed system modifications required. Experimental procedures were successful for producing hydrogen from biomass using the bacteria Thermotoga, a deep-ocean thermal vent organism. Analytical procedures for hydrogen were evaluated, a gas chromatography (GC) method was derived for measuring hydrogen yields, and adaptation culturing and protocols for mutagenesis were initiated to better develop strains that can use biomass cellulose. Fly ash derived from

  16. YEAR 2 BIOMASS UTILIZATION

    Energy Technology Data Exchange (ETDEWEB)

    Christopher J. Zygarlicke

    2004-11-01

    This Energy & Environmental Research Center (EERC) Year 2 Biomass Utilization Final Technical Report summarizes multiple projects in biopower or bioenergy, transportation biofuels, and bioproducts. A prototype of a novel advanced power system, termed the high-temperature air furnace (HITAF), was tested for performance while converting biomass and coal blends to energy. Three biomass fuels--wood residue or hog fuel, corn stover, and switchgrass--and Wyoming subbituminous coal were acquired for combustion tests in the 3-million-Btu/hr system. Blend levels were 20% biomass--80% coal on a heat basis. Hog fuel was prepared for the upcoming combustion test by air-drying and processing through a hammer mill and screen. A K-Tron biomass feeder capable of operating in both gravimetric and volumetric modes was selected as the HITAF feed system. Two oxide dispersion-strengthened (ODS) alloys that would be used in the HITAF high-temperature heat exchanger were tested for slag corrosion rates. An alumina layer formed on one particular alloy, which was more corrosion-resistant than a chromia layer that formed on the other alloy. Research activities were completed in the development of an atmospheric pressure, fluidized-bed pyrolysis-type system called the controlled spontaneous reactor (CSR), which is used to process and condition biomass. Tree trimmings were physically and chemically altered by the CSR process, resulting in a fuel that was very suitable for feeding into a coal combustion or gasification system with little or no feed system modifications required. Experimental procedures were successful for producing hydrogen from biomass using the bacteria Thermotoga, a deep-ocean thermal vent organism. Analytical procedures for hydrogen were evaluated, a gas chromatography (GC) method was derived for measuring hydrogen yields, and adaptation culturing and protocols for mutagenesis were initiated to better develop strains that can use biomass cellulose. Fly ash derived from

  17. Systems and methods for solar energy storage, transportation, and conversion utilizing photochemically active organometallic isomeric compounds and solid-state catalysts

    Energy Technology Data Exchange (ETDEWEB)

    Vollhardt, K. Peter C.; Segalman, Rachel A; Majumdar, Arunava; Meier, Steven

    2015-02-10

    A system for converting solar energy to chemical energy, and, subsequently, to thermal energy includes a light-harvesting station, a storage station, and a thermal energy release station. The system may include additional stations for converting the released thermal energy to other energy forms, e.g., to electrical energy and mechanical work. At the light-harvesting station, a photochemically active first organometallic compound, e.g., a fulvalenyl diruthenium complex, is exposed to light and is photochemically converted to a second, higher-energy organometallic compound, which is then transported to a storage station. At the storage station, the high-energy organometallic compound is stored for a desired time and/or is transported to a desired location for thermal energy release. At the thermal energy release station, the high-energy organometallic compound is catalytically converted back to the photochemically active organometallic compound by an exothermic process, while the released thermal energy is captured for subsequent use.

  18. The clinical utility of tuberculin skin test and interferon-γ release assay in the diagnosis of active tuberculosis among young adults: a prospective observational study

    Directory of Open Access Journals (Sweden)

    Lee Sei Won

    2011-04-01

    Full Text Available Abstract Background The roles of the tuberculin skin test (TST and QuantiFERON®-TB Gold In-Tube assay (QFT-IT in the diagnosis of active tuberculosis (TB are not clear in young adults. We evaluated the diagnostic accuracy of the TST and QFT-IT in smear-negative TB among young adults with no underlying disease. Methods We prospectively enrolled 166 young participants 20-29 years of age with suspected active TB in a military hospital of South Korea. The TST and QFT-IT were performed for all participants. Results Of the 143 patients included in the analysis, active TB was diagnosed in 100 (69.9%. There were 141 male patients, none of whom had immunosuppressive disease. The sensitivity, specificity, positive predictive value (PPV, and negative predictive value (NPV of TST were 94% (95% CI, 87-98%, 88% (95% CI, 74-96%, 95% (95% CI, 88-98%, and 86% (95% CI, 72-94%, respectively. The sensitivity, specificity, PPV, and NPV of the QFT-IT were 93% (95% CI, 86-97%, 95% (95% CI, 81-99%, 98% (95% CI, 92-99%, and 84% (95% CI, 69-93%, respectively. No significant differences were found between the TST and QFT-IT in any statistic. Conclusions Both the TST and QFT-IT showed high sensitivity and specificity in differentiating active TB from other diseases. The diagnostic accuracy of these two tests did not differ significantly when applied to this clinical population of young, immunocompetent adults in whom neonatal BCG vaccination was common, there was no history of previous TB and in whom suspicion of TB was high. Trial registration ClinicalTrials.gov: NCT00982969

  19. Teaching retirement financial literacy in an undergraduate gerontology classroom: broadening the concept of the tripod or three-legged stool of retirement income utilizing active learning.

    Science.gov (United States)

    Baker, Hallie E; Brown, Pamela Pitman

    2015-01-01

    The three-legged stool concept is widely used in gerontological and geriatric education as an explanation on how one should fiscally approach his or her retirement. Financial managers, planners, retirees, business owners, even the Social Security Administration uses this metaphor of fiscal soundness in retirement planning. Gerontologists are moving away from the "tripod of retirement income" and "three-legged stool" term, as more often market work is needed for financial security. This activity focuses on the tripod or three-legged stool concepts of retirement planning using active learning, allowing the students to work collaboratively in a group, reflect upon the activity, and most importantly have fun. The game also allows for an expansion of the tripod concepts into the four pillars of economic security, broaching the use of personal assets and the possible need for longer employment. Game scenarios also emphasize macro- and microlevel forces, such as race, gender, health status, education, or marital status, which can influence timing of retirement or the level of retirement income available. The authors include instructions on how to set up the learning experience including worksheets, as well as reflection questions posed throughout the process.

  20. PFBC Utility Demonstration Project

    Energy Technology Data Exchange (ETDEWEB)

    1992-11-01

    This report provides a summary of activities by American Electric Power Service Corporation during the first budget period of the PFBC Utility Demonstration Project. In April 1990, AEP signed a Cooperative Agreement with the US Department of Energy to repower the Philip Sporn Plant, Units 3 4 in New Haven, West Virginia, with a 330 KW PFBC plant. The purpose of the program was to demonstrate and verify PFBC in a full-scale commercial plant. The technical and cost baselines of the Cooperative Agreement were based on a preliminary engineering and design and a cost estimate developed by AEP subsequent to AEP's proposal submittal in May 1988, and prior to the signing of the Cooperative Agreement. The Statement of Work in the first budget period of the Cooperative Agreement included a task to develop a preliminary design and cost estimate for erecting a Greenfield plant and to conduct a comparison with the repowering option. The comparative assessment of the options concluded that erecting a Greenfield plant rather than repowering the existing Sporn Plant could be the technically and economically superior alternative. The Greenfield plant would have a capacity of 340 MW. The ten additional MW output is due to the ability to better match the steam cycle to the PFBC system with a new balance of plant design. In addition to this study, the conceptual design of the Sporn Repowering led to several items which warranted optimization studies with the goal to develop a more cost effective design.

  1. Domestic utility attitudes toward foreign uranium supply

    Energy Technology Data Exchange (ETDEWEB)

    1981-06-01

    The current embargo on the enrichment of foreign-origin uranium for use in domestic utilization facilities is scheduled to be removed in 1984. The pending removal of this embargo, complicated by a depressed worldwide market for uranium, has prompted consideration of a new or extended embargo within the US Government. As part of its on-going data collection activities, Nuclear Resources International (NRI) has surveyed 50 domestic utility/utility holding companies (representing 60 lead operator-utilities) on their foreign uranium purchase strategies and intentions. The most recent survey was conducted in early May 1981. A number of qualitative observations were made during the course of the survey. The major observations are: domestic utility views toward foreign uranium purchase are dynamic; all but three utilities had some considered foreign purchase strategy; some utilities have problems with buying foreign uranium from particular countries; an inducement is often required by some utilities to buy foreign uranium; opinions varied among utilities concerning the viability of the domestic uranium industry; and many utilities could have foreign uranium fed through their domestic uranium contracts (indirect purchases). The above observations are expanded in the final section of the report. However, it should be noted that two of the observations are particularly important and should be seriously considered in formulation of foreign uranium import restrictions. These important observations are the dynamic nature of the subject matter and the potentially large and imbalanced effect the indirect purchases could have on utility foreign uranium procurement.

  2. 41 CFR 109-39.301 - Utilization guidelines.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Utilization guidelines... Management System Vehicles § 109-39.301 Utilization guidelines. DOE activities utilizing GSA IFMS motor... meeting DOE utilization guidelines or established local use objectives, as appropriate. Those vehicles...

  3. The Utility Battery Storage Systems Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    1994-11-01

    Utility battery energy storage allows a utility or customer to store electrical energy for dispatch at a time when its use is more economical, strategic, or efficient. The UBS program sponsors systems analyses, technology development of subsystems and systems integration, laboratory and field evaluation, and industry outreach. Achievements and planned activities in each area are discussed.

  4. Amyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons.

    Directory of Open Access Journals (Sweden)

    Keifer P Walsh

    Full Text Available Neurites of neurons under acute or chronic stress form bundles of filaments (rods containing 1∶1 cofilin∶actin, which impair transport and synaptic function. Rods contain disulfide cross-linked cofilin and are induced by treatments resulting in oxidative stress. Rods form rapidly (5-30 min in >80% of cultured hippocampal or cortical neurons treated with excitotoxic levels of glutamate or energy depleted (hypoxia/ischemia or mitochondrial inhibitors. In contrast, slow rod formation (50% of maximum response in ∼6 h occurs in a subpopulation (∼20% of hippocampal neurons upon exposure to soluble human amyloid-β dimer/trimer (Aβd/t at subnanomolar concentrations. Here we show that proinflammatory cytokines (TNFα, IL-1β, IL-6 also induce rods at the same rate and within the same neuronal population as Aβd/t. Neurons from prion (PrP(C-null mice form rods in response to glutamate or antimycin A, but not in response to proinflammatory cytokines or Aβd/t. Two pathways inducing rod formation were confirmed by demonstrating that NADPH-oxidase (NOX activity is required for prion-dependent rod formation, but not for rods induced by glutamate or energy depletion. Surprisingly, overexpression of PrP(C is by itself sufficient to induce rods in over 40% of hippocampal neurons through the NOX-dependent pathway. Persistence of PrP(C-dependent rods requires the continuous activity of NOX. Removing inducers or inhibiting NOX activity in cells containing PrP(C-dependent rods causes rod disappearance with a half-life of about 36 min. Cofilin-actin rods provide a mechanism for synapse loss bridging the amyloid and cytokine hypotheses for Alzheimer disease, and may explain how functionally diverse Aβ-binding membrane proteins induce synaptic dysfunction.

  5. Electroluminescence of a Multi-Layered Organic Light-Emitting Diode Utilizing Trans-4-[p-[Nmethyl-N-(hydroxymethyl)amino]styryl]-N-Methylphridinium Tetraphenylborate as the Active Layer

    Institute of Scientific and Technical Information of China (English)

    FENG Xue-Yuan; ZHANG Jia-Yu; XU Chun-Xiang; QIAO Yi; GUI Yi-Ping

    2006-01-01

    Employing an organic dye salt oftrans-4-[p-[N-methyl-N-(hydroxymethyl)amino]styryl]-N-methylphridinium tetraphenylborate (ASPT) as the active layer, 8-hydrocyquinoline aluminium (Alqa) as the electron transporting layer and N,Nt-diphenyl-N,Nl-bis(3-methylphenyl)-[l,l'-biphenyl]-4,4'-diamine (TPD) as the hole transporting layer, respectively, we fabricate a multi-layered organic light-emitting diode and observe the colour tunable electroluminescence (EL). The dependence of the EL spectra on the applied voltage is investigated in detail, and the recombination mechanism is discussed by considering the variation of the hole-electron recombination region.

  6. Utilization of various agricultural wastes for activated carbon preparation and application for the removal of dyes and metal ions from aqueous solutions.

    Science.gov (United States)

    Kadirvelu, K; Kavipriya, M; Karthika, C; Radhika, M; Vennilamani, N; Pattabhi, S

    2003-03-01

    Activated carbons were prepared from the agricultural solid wastes, silk cotton hull, coconut tree sawdust, sago waste, maize cob and banana pith and used to eliminate heavy metals and dyes from aqueous solution. Adsorption of all dyes and metal ions required a very short time and gave quantitative removal. Experimental results show all carbons were effective for the removal of pollutants from water. Since all agricultural solid wastes used in this investigation are freely, abundantly and locally available, the resulting carbons are expected to be economically viable for wastewater treatment.

  7. Utilization of activated carbon loaded with sulphur for sulphur fertilization in agriculture; Verwertung von mit Schwefel beladener Aktivkohle als Schwefelduenger in der Landwirtschaft

    Energy Technology Data Exchange (ETDEWEB)

    Kirfel, Kristina; Hoffmann, Heide [Humboldt Univ. Berlin (Germany). AG Agraroekologie und Oekologischer Landbau

    2013-01-15

    Due to the decrease of atmospheric sulphur deposition, sulphur fertilization has gained significance for agriculture in recent years. Carbon-sulphur-pellets (CSP), activated carbon pellets loaded with sulphur, previously used for desulphurization in biogas plants, are up to now disposed of as waste. In this context the question arises if CSP could be of use for sulphur fertilization of agricultural crops. The objective of this study was to test sulphur release and plant availability from, and plant tolerance towards CSP. A pot experiment using Zea mays with different shares of CSP was carried out. Leaf green intensity of vital plants, indicating plants' current nutritional status, was measured and differences in plant development were documented regularly. At the end of the trial period biomass and elemental contents of the test plants, as well as electrical conductivity and pH-value of the substrate-CSP-mixtures were determined. Amendments of 0.2 m.-% to 1.0 m.-% had a positive effect on plants' dry mass yield; higher shares led to considerable yield losses. By addition of CSP, sulphur content in the plant dry mass increased compared to the control without sulphur fertilization. This result indicates that sulphur adsorbed to activated carbon becomes plant available when applicated to cultural substrate. (orig.)

  8. Non-noble metal Bi deposition by utilizing Bi2WO6 as the self-sacrificing template for enhancing visible light photocatalytic activity

    Science.gov (United States)

    Yu, Shixin; Zhang, Yihe; Li, Min; Du, Xin; Huang, Hongwei

    2017-01-01

    Bi metal deposited on Bi2WO6 composite photocatalysts have been successfully synthesized via a simple in-situ reduction method at room temperature with using Bi2WO6 as self-sacrificing template and NaBH4 as reducing agent. The reduction extent can be easily modulated by controlling the concentration of NaBH4 solution. X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Fourier-transform infrared (FTIR) spectra, N2 adsorption-desorption isotherms, scanning electron microscopy (SEM), transmission electron microscopy (TEM), high resolution TEM (HRTEM), diffuse reflection spectroscopy (DRS) and photoelectrochemical measurements were carried out to analyze the phase, morphology, optical property and photoelectrochemical property of the as-prepared samples. The photocatalytic activity is surveyed by degradation of phenol under visible light (λ > 420 nm), which showed that the BWO-0.2 photocatalyst exhibited the highest efficiency, which was over 3 times as high as pure Bi2WO6. The enhanced photocatalytic activity should be attributed to strengthened photoabsorption and charge separation efficiency derived from the surface plasmon resonance (SPR) of Bi metal.

  9. Brain Activity Stimulated by Prism Adaptation Tasks Utilized for the Treatment of Unilateral Spatial Neglect: A Study with fNIRS

    Directory of Open Access Journals (Sweden)

    Hiroshi Taniguchi

    2012-01-01

    Full Text Available We investigated the neurological basis for efficacy of prism adaptation therapy, which is used for the treatment of poststroke unilateral spatial neglect (USN. Study subjects were 6 USN-positive (+, 6 USN-negative patients, and 6 healthy volunteer control subjects. USN was identified by the Behavioural Inattention Test (BIT. During the tasks, brain activity was assessed with fNIRS via changes in oxyHb concentration per unit length. There was no significant difference in the number of errors in the task between the 3 groups. However, in the USN(+ group there was a significantly greater reduction in oxyHb levels in the right parietal association cortex during the prism adaptation task than in the other 2 groups (<0.05. There was an immediate improvement in USN symptoms as well as a significant increase in oxyHb levels during the prism adaptation in the channels covering the right frontal and parietal lobes in 2 patients in the USN(+ group (<0.05. This result suggested that decreased activity in the right parietal association cortex, which is related to spatial perception, during the prism adaptation task and task-induced reorganization of the right frontal and parietal areas were involved in improvement in USN symptoms.

  10. A mutation in the COX5 gene of the yeast Scheffersomyces stipitis alters utilization of amino acids as carbon source, ethanol formation and activity of cyanide insensitive respiration.

    Science.gov (United States)

    Freese, Stefan; Passoth, Volkmar; Klinner, Ulrich

    2011-04-01

    Scheffersomyces stipitis PJH was mutagenized by random integrative mutagenesis and the integrants were screened for lacking the ability to grow with glutamate as sole carbon source. One of the two isolated mutants was damaged in the COX5 gene, which encodes a subunit of the cytochrome c oxidase. BLAST searches in the genome of Sc. stipitis revealed that only one singular COX5 gene exists in Sc. stipitis, in contrast to Saccharomyces cerevisiae, where two homologous genes are present. Mutant cells had lost the ability to grow with the amino acids glutamate, proline or aspartate and other non-fermentable carbon sources, such as acetic acid and ethanol, as sole carbon sources. Biomass formation of the mutant cells in medium containing glucose or xylose as carbon source was lower compared with the wild-type cells. However, yields and specific ethanol formation of the mutant were much higher, especially under conditions of higher aeration. The mutant cells lacked both cytochrome c oxidase activity and cyanide-sensitive respiration, whereas ADH and PDC activities were distinctly enhanced. SHAM-sensitive respiration was obviously essential for the fermentative metabolism, because SHAM completely abolished growth of the mutant cells with both glucose or xylose as carbon source.

  11. Utilization of radioanalytical methods for the determination of isotopes of U, Pu and Am in activated charcoal from IEA-R1 reactor

    Energy Technology Data Exchange (ETDEWEB)

    Geraldo, Bianca; Marumo, Julio T., E-mail: bgeraldo@ipen.br, E-mail: jtmarumo@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Taddei, Maria Helena T., E-mail: mhtaddei@cnen.gov.br [Laboratorio de Pocos de Caldas (LAPOC/CNEN-MG), Pocos de Caldas, MG (Brazil)

    2013-07-01

    Activated charcoal is a radioactive waste arising from the water purification system of the nuclear research reactor. The management of this waste includes its characterization in order to identify and quantify the existing radionuclides, including those known as 'difficult-to-measure radionuclides' (RDM). The analysis of these RDM usually involves complex radiochemical costly and time consuming procedures for the purification and separation of them. The objective of this work was to define a methodology of sequential analysis of isotopes of U, Pu and Am, present in activated charcoal, evaluating chemical recovery, analysis time, quantity of radioactive waste generated and cost. Ion exchange and the chromatographic extraction methodologies were compared. Both methods showed high chemical recoveries, ranged from 74 and 100% for U, 76 and 100% for Pu and 87 and 100% for Am, demonstrating that these methods provide accurate and reliable results. However, chromatographic extraction method is more suitable for the determination of the radionuclides because it generates the smaller volume of waste and is more cost-effectively. (author)

  12. Super climate for Vodafone Italia. Utilization of active chilled beams for a monument protected sanitation; Prima Klima fuer Vodafone Italia. Einsatz aktiver Kuehlbalken fuer ein denkmalgeschuetztes Sanierungsprojekt

    Energy Technology Data Exchange (ETDEWEB)

    Sefker, T.; Joneleit, R. [Trox GmbH, Neukirchen-Vluyn (Germany)

    2008-03-15

    Vodafone Italia moved as a new user into the former Olivetti headquarter (ICO) at the Italian Ivrea. A total sanitation was done of the outer envelope and facility management of the monument protected building. To secure a best possible comfort in the as call-center used open-plan offices and in the single bureaus the responsibles decided for an active chilled beam system with fresh air inlet and secondary air cooling. Chilled beams can save energy by delivering sensible cooling directly to spaces, decoupling maximum air delivery from the cooling load and reducing ventilation fan energy consumption; meet standard ventilation requirements with less ventilation airflow; has lower temperature lift and operates at higher efficiency; and reduces the need for energy-consuming reheat of cooled air. (GL)

  13. Utilizing time-driven activity-based costing to understand the short- and long-term costs of treating localized, low-risk prostate cancer.

    Science.gov (United States)

    Laviana, Aaron A; Ilg, Annette M; Veruttipong, Darlene; Tan, Hung-Jui; Burke, Michael A; Niedzwiecki, Douglas R; Kupelian, Patrick A; King, Chris R; Steinberg, Michael L; Kundavaram, Chandan R; Kamrava, Mitchell; Kaplan, Alan L; Moriarity, Andrew K; Hsu, William; Margolis, Daniel J A; Hu, Jim C; Saigal, Christopher S

    2016-02-01

    Given the costs of delivering care for men with prostate cancer remain poorly described, this article reports the results of time-driven activity-based costing (TDABC) for competing treatments of low-risk prostate cancer. Process maps were developed for each phase of care from the initial urologic visit through 12 years of follow-up for robotic-assisted laparoscopic prostatectomy (RALP), cryotherapy, high-dose rate (HDR) and low-dose rate (LDR) brachytherapy, intensity-modulated radiation therapy (IMRT), stereotactic body radiation therapy (SBRT), and active surveillance (AS). The last modality incorporated both traditional transrectal ultrasound (TRUS) biopsy and multiparametric-MRI/TRUS fusion biopsy. The costs of materials, equipment, personnel, and space were calculated per unit of time and based on the relative proportion of capacity used. TDABC for each treatment was defined as the sum of its resources. Substantial cost variation was observed at 5 years, with costs ranging from $7,298 for AS to $23,565 for IMRT, and they remained consistent through 12 years of follow-up. LDR brachytherapy ($8,978) was notably cheaper than HDR brachytherapy ($11,448), and SBRT ($11,665) was notably cheaper than IMRT, with the cost savings attributable to shorter procedure times and fewer visits required for treatment. Both equipment costs and an inpatient stay ($2,306) contributed to the high cost of RALP ($16,946). Cryotherapy ($11,215) was more costly than LDR brachytherapy, largely because of increased single-use equipment costs ($6,292 vs $1,921). AS reached cost equivalence with LDR brachytherapy after 7 years of follow-up. The use of TDABC is feasible for analyzing cancer services and provides insights into cost-reduction tactics in an era focused on emphasizing value. By detailing all steps from diagnosis and treatment through 12 years of follow-up for low-risk prostate cancer, this study has demonstrated significant cost variation between competing treatments. © 2015

  14. 柚子全果综合利用及生物活性研究进展%Research Progress of Comprehensive Utilization and Biological Activity of Grapefruit Fruit

    Institute of Scientific and Technical Information of China (English)

    杨宁

    2015-01-01

    Grapefruit is rutaceae citrus fruit, and grapefruit pulp not only contains rich glycosides substances, vitamins, minerals, and insulin composition, but also has important biological functions. Grapefruit peel accounts for 43% ~48% of the whole grapefruit, which contains flavonoids, natural pigment, dietary fiber, limonin, essential oil and else active ingredients. The medical research shows that the grapefruit peel extract has many physiological activities for strong antioxidant, anticancer, antibacterial and blood sugar fall and so on. The comprehensive utilization of grapefruit fruit and biological activity research were clarified in detail which can provide guidance for the comprehensive utilization and development of whole grapefruit fruit resources.%柚子是芸香料柑橘属水果,柚子肉不仅含有丰富的甙类物质、维生素、矿物质,类胰岛素等成分,而且还具有重要的生物学功能。柚皮占整个柚子的43%~48%,含有黄酮类化合物、天然色素、膳食纤维、柠檬苦素、香精油等活性成分。这些成分赋予柚皮提取物具有抗氧化、抗癌、抑菌和降血糖等生理活性。本文对柚子全果综合利用及生物活性研究详细阐述,可以为我国柚子全果资源的综合利用开发提供指导。

  15. Study on information utility

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Information has two aspects. One aspect is the objective one; another aspect is the subjective one. Shannon has discussed the objective aspect of information in information theory. But the subjective aspect of information has not been fully discussed. Someone use "Bayesian approaches" to evaluate the value of information. But in some cases it does not meet the information user's need. This paper is focus on the subjective aspect of objectively measurable information and gives formal definitions for information, information utility, and marginal information utility, normalized calculation of information utility. The information discussed in the paper has interdisciplinary nature. This work can be the foundation of many application areas.

  16. Human recombinant macrophage inflammatory protein-1 alpha and -beta and monocyte chemotactic and activating factor utilize common and unique receptors on human monocytes.

    Science.gov (United States)

    Wang, J M; Sherry, B; Fivash, M J; Kelvin, D J; Oppenheim, J J

    1993-04-01

    The human macrophage inflammatory proteins-1 alpha and -beta (MIP-1 alpha and -beta), which are also known as LD78 and ACT2, respectively, are distinct but highly related members of the chemoattractant cytokine (chemokine) family. rMIP-1 alpha and -beta labeled with 125I specifically bind to human peripheral blood monocytes, the monocytic cell line THP-1, peripheral blood T cells, and the YT cell line. Steady state binding experiments revealed approximately 3000 high affinity binding sites/cell for MIP-1 alpha on human monocytes and on THP-1 cells, with Kd values of 383 pM and 450 pM, respectively. Human MIP-1 alpha and -beta had nearly identical affinities for the binding sites and each competed equally well for binding. Human monocyte chemotactic and activating factor (MCAF), a member of the same chemokine family, consistently displaced about 25% of human MIP-1 alpha and -beta binding on monocytes but not on YT cells, which did not bind MCAF. On the other hand, human rMIP-1 alpha and -beta partially inhibited binding of radiolabeled MCAF to monocytes. Both MIP-1 alpha and -beta were chemotactic for human monocytes. Preincubation of monocytes with human rMIP-1 alpha or -beta markedly reduced cell migration towards the other cytokine, whereas preincubation with human rMCAF only partially desensitized the monocyte chemotaxis response to human rMIP-1 alpha or -beta. These data suggest the existence of three subtypes of receptors, i.e., one unique receptor shared by MIP-1 alpha and -beta, a second unique receptor for MCAF, and a third species that recognizes both MCAF and MIP-1 peptides.

  17. Metabolic Pathway for Propionate Utilization by Phosphorus-Accumulating Organisms in Activated Sludge: 13C Labeling and In Vivo Nuclear Magnetic Resonance

    Science.gov (United States)

    Lemos, Paulo C.; Serafim, Luísa S.; Santos, Margarida M.; Reis, Maria A. M.; Santos, Helena

    2003-01-01

    In vivo 13C and 31P nuclear magnetic resonance techniques were used to study propionate metabolism by activated sludge in enhanced biological phosphorus removal systems. The fate of label supplied in [3-13C]propionate was monitored in living cells subjected to anaerobic/aerobic cycles. During the anaerobic phase, propionate was converted to polyhydroxyalkanoates (PHA) with the following monomer composition: hydroxyvalerate, 74.2%; hydroxymethylvalerate, 16.9%; hydroxymethylbutyrate, 8.6%; and hydroxybutyrate, 0.3%. The isotopic enrichment in the different carbon atoms of hydroxyvalerate (HV) produced during the first anaerobic stage was determined: HV5, 59%; HV4, 5.0%; HV3, 1.1%; HV2, 3.5%; and HV1, 2.8%. A large proportion of the supplied label ended up on carbon C-5 of HV, directly derived from the pool of propionyl-coenzyme A (CoA), which is primarily labeled on C-3; useful information on the nature of operating metabolic pathways was provided by the extent of labeling on C-1, C-2, and C-4. The labeling pattern on C-1 and C-2 was explained by the conversion of propionyl-CoA to acetyl-CoA via succinyl-CoA and the left branch of the tricarboxylic acid cycle, which involves scrambling of label between the inner carbons of succinate. This constitutes solid evidence for the operation of succinate dehydrogenase under anaerobic conditions. The labeling in HV4 is explained by backflux from succinate to propionyl-CoA. The involvement of glycogen in the metabolism of propionate was also demonstrated; moreover, it was shown that the acetyl moiety to the synthesis of PHA was derived preferentially from glycogen. According to the proposed metabolic scheme, the decarboxylation of pyruvate is coupled to the production of hydrogen, and the missing reducing equivalents should be derived from a source other than glycogen metabolism. PMID:12514001

  18. Expression and/or activity of the SVCT2 ascorbate transporter may be decreased in many aggressive cancers, suggesting potential utility for sodium bicarbonate and dehydroascorbic acid in cancer therapy.

    Science.gov (United States)

    McCarty, Mark F

    2013-10-01

    rendering them less aggressive. Indeed, several published studies have concluded that parenteral DHA--sometimes in quite modest doses--can retard the growth of transplanted tumors in rodents. As an alternative or adjunctive strategy, oral administration of sodium bicarbonate, by normalizing the extracellular pH of tumors, has the potential to boost the activity of SCTV2 in tumor cells, thereby promoting increased ascorbate uptake. Indeed, the utility of oral sodium bicarbonate for suppressing metastasis formation in nude mice xenografted with a human breast cancer has been reported. Hence, oral sodium bicarbonate and intravenous DHA may have the potential to blunt the aggressiveness of certain cancers in which suboptimal intracellular ascorbate levels contribute to elevated HIF-1 activity.

  19. Information, Utility & Bounded Rationality

    CERN Document Server

    Ortega, Pedro A

    2011-01-01

    Perfectly rational decision-makers maximize expected utility, but crucially ignore the resource costs incurred when determining optimal actions. Here we employ an axiomatic framework for bounded rational decision-making based on a thermodynamic interpretation of resource costs as information costs. This leads to a variational "free utility" principle akin to thermodynamical free energy that trades off utility and information costs. We show that bounded optimal control solutions can be derived from this variational principle, which leads in general to stochastic policies. Furthermore, we show that risk-sensitive and robust (minimax) control schemes fall out naturally from this framework if the environment is considered as a bounded rational and perfectly rational opponent, respectively. When resource costs are ignored, the maximum expected utility principle is recovered.

  20. Chemical Search Web Utility

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Chemical Search Web Utility is an intuitive web application that allows the public to easily find the chemical that they are interested in using, and which...

  1. Utilization of lignin

    Energy Technology Data Exchange (ETDEWEB)

    Machihara, A.

    1981-01-01

    The chemical structure of lignin, the composition of pulping spent liquors, conversion of lignin into fine chemicals, utilization of lignin products, and physical and chemical properties of lignin and and derivatives are reviewed. (Refs 29).

  2. UtilityOther_ELCFRANCHISE

    Data.gov (United States)

    Vermont Center for Geographic Information — ELCFRANCHISE includes Vermont's Electric Utility Franchise boundaries. It is a compilation of many data sources. The boundaries are approximate and should be used...

  3. UtilityTelecom_TELEFAC

    Data.gov (United States)

    Vermont Center for Geographic Information — The UtilityTelecom_TELEFAC data layer contains points which are intended to represent the location of telecommunications facilities (towers and/or antennas) in...

  4. Biotechnology of space utilization

    Energy Technology Data Exchange (ETDEWEB)

    Matsumiya, Hiroyuki

    1989-10-05

    This paper introdued the practical results of biotechnological experiments utilizing features of space and the present Japanese plan. The electrophoresis and crystal growth of protein utilize the microgravity field and cell culture utilizes the influence of microgravity on organism. Of practical results in space experiments, the electrophoresis was made by US but others were carried out by Europian countries. It was thought that the electrophoresis utilizing space environment could be demonstrated to be promosing for the separating and refining techniques by the experiment on the basis of the Apolo Project. The crystal growth of protein was reported by Litke of Denmark as to the crystal of lyzozyme. The space experiment of cell culture was carried out by Cogoli of Switzerland as to the culture of lymphocyte in the Shattle. Japan is studying the primary material experiment project(FMPT) in the Space Shattle and unmanned experiment for electrophoresis. 9 refs., 3 tabs.

  5. MSIS Drug Utilization Datamart

    Data.gov (United States)

    U.S. Department of Health & Human Services — This page provides background needed to take advantage of the capabilities of the MSIS Drug Utilization Datamart. This mart allows the user to develop high-level...

  6. 辣木的有效成分、保健功能和开发利用研究进展%Research Progress on Active Ingredients, Health Care Functions, Development and Utilization of Moringa oleifera

    Institute of Scientific and Technical Information of China (English)

    孙丹; 管俊岭; 许玫; 李涛; 陈文品

    2016-01-01

    Moringa oleifera belongs to Moringaceae Moringa Adans'hot tropical deciduous woody vegetables and oil crops, having a high nutritional value and unique biological activity, with great development potential. This article reviewed the extraction of moringa oil, protein, total flavonoids et al;and the function of anti-oxidation and protecting the liver, lowering blood sugar and blood fat, anti-bacterial and anti-inflammatory and other health functions,besides, the development and utilization were also reviewed, hoping to provide a reference for the comprehensive development and utilization of Moringa oleifera resources.%辣木(Moringa oleifera)是辣木科辣木属的热带落叶木本蔬菜及油料作物,有着丰富的营养价值和独特的生物活性,极具开发潜力。从辣木有效成分辣木油、蛋白质、总黄酮等的提取,抗氧化及保护肝脏、降血糖、降血脂、抗菌消炎等保健功能和开发利用等方面进行综述,为辣木资源的研究利用提供参考。

  7. Códigos de activación en urgencias y emergencias: La utilidad de priorizar Activation codes in urgency and emergency care: The utility of prioritising

    Directory of Open Access Journals (Sweden)

    X. Jiménez Fàbrega

    2010-01-01

    , i.e. cardiac arrest, stroke, trauma, acute coronary syndrome or sepsis. The creation of systems of coordination between care levels involving different levels of complexity has made possible the implementation and, finally, the consolidation of certain procedures agreed upon amongst all health professionals involved in the care process. These procedures, in a spontaneous and generic way, have been defined as «activation codes». The appearance of these codes apparently seems simple, but represents a challenge. On an emergency being detected, the receiving centre appropriate for the patient is warned through an emergency coordinating centre and the patient is taken to that centre. What is sought with the codes is coordinated team work, based on scientific protocols recognised by those involved in care and the scientific community, and avoidance of duplicated actions and unnecessary delays in actions with the patient. In short, their single aim is joint work in the patient's benefit.

  8. Utility requirements for fusion

    Energy Technology Data Exchange (ETDEWEB)

    Vondrasek, R.J.

    1982-02-01

    This report describes work done and results obtained during performance of Task 1 of a study of Utility Requirements and Criteria for Fusion Options. The work consisted of developing a list of utility requirements for fusion optics containing definition of the requirements and showing their relative importance to the utility industry. The project team members developed a preliminary list which was refined by discussions and literature searches. The refined list was recast as a questionnaire which was sent to a substantial portion of the utility industry in this country. Forty-three questionnaire recipients responded including thirty-two utilities. A workshop was held to develop a revised requirements list using the survey responses as a major input. The list prepared by the workshop was further refined by a panel consisting of vice presidents of the three project team firms. The results of the study indicate that in addition to considering the cost of energy for a power plant, utilities consider twenty-three other requirements. Four of the requirements were judged to be vital to plant acceptability: Plant Capital Cost, Financial Liability, Plant Safety and Licensability.

  9. Health care utilization

    DEFF Research Database (Denmark)

    Jacobsen, Christian Bøtcher; Andersen, Lotte Bøgh; Serritzlew, Søren

    An important task in governing health services is to control costs. The literatures on both costcontainment and supplier induced demand focus on the effects of economic incentives on health care costs, but insights from these literatures have never been integrated. This paper asks how economic cost...... make health professionals provide more of this service to each patient, but that lower user payment (unexpectedly) does not necessarily mean higher total cost or a stronger association between the number of patients per supplier and the health care utilization. This implies that incentives...... are important, but that economics cannot alone explain the differences in health care utilization....

  10. Energetic utilization of dietary fiber in pigs

    NARCIS (Netherlands)

    Rijnen, M.M.J.A.

    2003-01-01

    The energetic utilization of fermentable dietary fiber (fDF) of different fiber sources and its relation to physical activity and housing conditions was studied in three experiments. In all experiments the daily intake of digestible nutrients, nitrogen and energy balances, heat production, and activ

  11. 30 CFR 817.180 - Utility installations.

    Science.gov (United States)

    2010-07-01

    ... PERMANENT PROGRAM PERFORMANCE STANDARDS PERMANENT PROGRAM PERFORMANCE STANDARDS-UNDERGROUND MINING ACTIVITIES § 817.180 Utility installations. All underground mining activities shall be conducted in a manner...; oil, gas, and coal-slurry pipelines, railroads; electric and telephone lines; and water and sewage...

  12. Module utilization committee

    Science.gov (United States)

    Volkmer, K.; Praver, G.

    1984-01-01

    Photovoltaic collector modules were declared surplus to the needs of the U.S. Dept. of Energy. The Module Utilization Committee was formed to make appropriate disposition of the surplus modules on a national basis and to act as a broker for requests for these modules originating outside of the National Photovoltaics Program.

  13. Electric utilities in Illinois

    Energy Technology Data Exchange (ETDEWEB)

    1978-01-01

    Although the conference dealt specifically with concerns of the electric utilities in Illinois, the issues were dealt with in the national context as well. A separate abstract was prepared for each of the 5 sections of this proceeding. A total of 25 papers were presented. Section titles are: Forecasting, Planning and Siting, Reliability, Rates and Financing, and Future Developments.

  14. Report on promotion of utilization of radiation

    Energy Technology Data Exchange (ETDEWEB)

    1987-09-01

    This report presents results of studies made by the Atomic Energy Commission concerning research and development activities to be carried out in future to promote the utilization of radiation. First, the current state of radiation utilization is described, centering on practical applications, research and development activities (for practical and advanced applications), and international cooperation (with developing and advanced nations). The second part deals with activities required in future to promote practical utilization of radiation, research and development of advanced techniques, and cooperation to be offered to developing countries. Third, specific measures to be carried out for effective radiation utilization are described. For ..gamma..-rays and electron beams, which are widely in use at present, there are some economic and social problems remaining to be solved. For advanced utilization of radiation beams, further efforts should be focused on basic research on ..pi..-meson and ..mu..-particle beams and their application to canser treatment and nuclear fusion; research on monochromatic neutron beams; application of RI beams to the development of new materials and new analysis techniques, application of epithermal neutron beams to elementary radiography and CT; etc. The utilization, application and development of tracers are also described. (Nogami, K.).

  15. Utility applications program. Annual report for 1981

    Energy Technology Data Exchange (ETDEWEB)

    Doherty, T.J.; Loscutoff, W.V.

    1982-06-01

    The purpose of the Utility Applications Program is to provide information and assistance to interested utilities on central station energy storage systems. Compressed air and underground pumped hydroelectric energy storage are the primary technical focus. Smaller utilities are the primary targets of this program, as they may not have resources to track and utilize new energy conservation developments. The program, initiated during this year-long period, consists of a series of tasks integrating and supporting energy storage implementation. Program management and technical coordination activities monitor the wide range of research ongoing both under government support and in industry and provide a locus for dissemination of results. Recently completed DOE demonstration studies provide the central data base and the DOE CAES and UPH Technology Program activities provide another major resource. In addition a UPH preliminary feasibility study in coorination with Central Vermont Public Servie (CVPS), a Northeast utility, was carried out. The major program activity this period was a comprehensive technology assessment and environmental siting study, performed in coordination with the Soyland Power Cooperative in Decatur, Illinois. The reports from this work established solid siting precedents for CAES application in the US and jointly assisted the utility in assembling the required baseline information for ongoing technical and financial development of the first US compressed air energy storage facility.

  16. Utilities:Other:Utilities at Pipe Spring National Monument, Arizona (Utilities.gdb:Other:utilpnt_other)

    Data.gov (United States)

    National Park Service, Department of the Interior — This feature class represents various types of utilities, not including water- and power-related utilities, at Pipe Spring National Monument, Arizona. The utilities...

  17. Protocol investigating the clinical utility of an objective measure of activity and attention (QbTest) on diagnostic and treatment decision-making in children and young people with ADHD-'Assessing QbTest Utility in ADHD' (AQUA): a randomised controlled trial.

    Science.gov (United States)

    Hall, Charlotte L; Walker, Gemma M; Valentine, Althea Z; Guo, Boliang; Kaylor-Hughes, Catherine; James, Marilyn; Daley, David; Sayal, Kapil; Hollis, Chris

    2014-12-01

    The National Institute for Health and Care Excellence (NICE) guidelines for attention deficit/hyperactivity disorder (ADHD) state that young people need to have access to the best evidence-based care to improve outcome. The current 'gold standard' ADHD diagnostic assessment combines clinical observation with subjective parent, teacher and self-reports. In routine practice, reports from multiple informants may be unavailable or contradictory, leading to diagnostic uncertainty and delay. The addition of objective tests of attention and activity may help reduce diagnostic uncertainty and delays in initiating treatment leading to improved outcomes. This trial investigates whether providing clinicians with an objective report of levels of attention, impulsivity and activity can lead to an earlier, and more accurate, clinical diagnosis and improved patient outcome. This multisite randomised controlled trial will recruit young people (aged 6-17 years old) who have been referred for an ADHD diagnostic assessment at Child and Adolescent Mental Health Services (CAMHS) and Community Paediatric clinics across England. Routine clinical assessment will be augmented by the QbTest, incorporating a continuous performance test (CPT) and infrared motion tracking of activity. The participant will be randomised into one of two study arms: QbOpen (clinician has immediate access to a QbTest report): QbBlind (report is withheld until the study end). Primary outcomes are time to diagnosis and diagnostic accuracy. Secondary outcomes include clinician's diagnostic confidence and routine clinical outcome measures. Cost-effective analysis will be conducted, alongside a qualitative assessment of the feasibility and acceptability of incorporating QbTest in routine practice. The findings from the study will inform commissioners, clinicians and managers about the feasibility, acceptability, clinical utility and cost-effectiveness of incorporating QbTest into routine diagnostic assessment of young

  18. Industrial coal utilization

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-01-01

    The effects of the National Energy Act on the use of coal in US industrial and utility power plants are considered. Innovative methods of using coal in an environmentally acceptable way are discussed: furnace types, fluidized-bed combustion, coal-oil-mixtures, coal firing in kilns and combustion of synthetic gas and liquid fuels. Fuel use in various industries is discussed with trends brought about by uncertain availability and price of natural gas and fuel oils: steel, chemical, cement, pulp and paper, glass and bricks. The symposium on Industrial Coal Utilization was sponsored by the US DOE, Pittsburgh Energy Technology Center, April 3 to 4, 1979. Twenty-one papers have been entered individually into the EDB. (LTN)

  19. Industrial coal utilization

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-01-01

    The effects of the National Energy Act on the use of coal in US industrial and utility power plants are considered. Innovative methods of using coal in an environmentally acceptable way are discussed: furnace types, fluidized-bed combustion, coal-oil-mixtures, coal firing in kilns and combustion of synthetic gas and liquid fuels. Fuel use in various industries is discussed with trends brought about by uncertain availability and price of natural gas and fuel oils: steel, chemical, cement, pulp and paper, glass and bricks. The symposium on Industrial Coal Utilization was sponsored by the US DOE, Pittsburgh Energy Technology Center, April 3 to 4, 1979. Twenty-one papers have been entered individually into the EDB. (LTN)

  20. UTILITY OF SIMPLIFIED LABANOTATION

    OpenAIRE

    Maria del Pilar Naranjo

    2016-01-01

    After using simplified Labanotation as a didactic tool for some years, the author can conclude that it accomplishes at least three main functions: efficiency of rehearsing time, social recognition and broadening of the choreographic consciousness of the dancer. The doubts of the dancing community about the issue of ‘to write or not to write’ are highly determined by the contexts and their own choreographic evolution, but the utility of Labanotation, as a tool for knowledge, is undeniable.

  1. Windpower utilization possibilities

    Science.gov (United States)

    Hoetzel, C.

    1982-01-01

    The possibilities of windpower utilization for mechanical pumps, electric generators, mechanical water vortex pumps, and heat pumps are reviewed. Application possibilities can be realized by windpower systems of different size. It must however be determined for which purpose and for which power range they are used. The site and the concomitant wind potential is of utmost importance. Small units in the 10 kW power range are very interesting for autonomous or semiautonomous energy supply.

  2. UTILITY OF SIMPLIFIED LABANOTATION

    Directory of Open Access Journals (Sweden)

    Maria del Pilar Naranjo

    2016-02-01

    Full Text Available After using simplified Labanotation as a didactic tool for some years, the author can conclude that it accomplishes at least three main functions: efficiency of rehearsing time, social recognition and broadening of the choreographic consciousness of the dancer. The doubts of the dancing community about the issue of ‘to write or not to write’ are highly determined by the contexts and their own choreographic evolution, but the utility of Labanotation, as a tool for knowledge, is undeniable.

  3. Time functions as utilities

    CERN Document Server

    Minguzzi, E

    2009-01-01

    Every time function on spacetime gives a (continuous) total preordering of the spacetime events which respects the notion of causal precedence. The problem of the existence of a (semi-)time function on spacetime and the problem of recovering the causal structure starting from the set of time functions are studied. It is pointed out that these problems have an analog in the field of microeconomics known as utility theory. In a chronological spacetime the semi-time functions correspond to the utilities for the chronological relation, while in a K-causal (stably causal) spacetime the time functions correspond to the utilities for the K^+ relation (Seifert's relation). By exploiting this analogy, we are able to import some mathematical results, most notably Peleg's and Levin's theorems, to the spacetime framework. As a consequence, we prove that a K-causal (i.e. stably causal) spacetime admits a time function and that the time or temporal functions can be used to recover the K^+ (or Seifert) relation which indeed...

  4. Recent trend in coal utilization technology. Coal utilization workshop

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Chon Ho; Son, Ja Ek; Lee, In Chul; Jin, Kyung Tae; Kim, Seong Soo [Korea Inst. of Energy Research, Taejon (Korea, Republic of)

    1995-12-01

    The 11th Korea-U.S.A. joint workshop on coal utilization technology was held in somerset, Pennsylvania, U.S.A. from october 2 to 3, 1995. In the opening ceremony, Dr.C. Low-el Miller, associate deputy assistant secretary of office of clean coal technology, U.S.DOE, gave congratulatory remarks and Dr. Young Mok Son, president of KIER, made a keynote address. In this workshop, 30 papers were presented in the fields of emission control technology, advanced power generation systems, and advanced coal cleaning and liquid fuels. Especially, from the Korean side, not only KIER but also other private research institutes and major engineering companies including KEPCO, Daewoo Institute of Construction Technology, Jindo Engineering and Construction Co. Daewoo Institute for Advanced Engineering and universities participated in this workshop, reflecting their great interests. Attendants actively discussed about various coal utilization technologies and exchanged scientific and technical information on the state-of-art clean coal technologies under development. (author)

  5. Hydrogen utilization potential in subsurface sediments

    DEFF Research Database (Denmark)

    Adhikari, Rishi Ram; Glombitza, Clemens; Nickel, Julia

    2016-01-01

    Pacific, and Gulf of Mexico) with different predominant electron-acceptors. Hydrogenases constitute a diverse family of enzymes expressed by microorganisms that utilize molecular hydrogen as a metabolic substrate, product, or intermediate. The assay reveals the potential for utilizing molecular hydrogen...... and allows qualitative detection of microbial activity irrespective of the predominant electron-accepting process. Because the method only requires samples frozen immediately after recovery, the assay can be used for identifying microbial activity in subsurface ecosystems without the need to preserve live...

  6. Time Functions as Utilities

    Science.gov (United States)

    Minguzzi, E.

    2010-09-01

    Every time function on spacetime gives a (continuous) total preordering of the spacetime events which respects the notion of causal precedence. The problem of the existence of a (semi-)time function on spacetime and the problem of recovering the causal structure starting from the set of time functions are studied. It is pointed out that these problems have an analog in the field of microeconomics known as utility theory. In a chronological spacetime the semi-time functions correspond to the utilities for the chronological relation, while in a K-causal (stably causal) spacetime the time functions correspond to the utilities for the K + relation (Seifert’s relation). By exploiting this analogy, we are able to import some mathematical results, most notably Peleg’s and Levin’s theorems, to the spacetime framework. As a consequence, we prove that a K-causal (i.e. stably causal) spacetime admits a time function and that the time or temporal functions can be used to recover the K + (or Seifert) relation which indeed turns out to be the intersection of the time or temporal orderings. This result tells us in which circumstances it is possible to recover the chronological or causal relation starting from the set of time or temporal functions allowed by the spacetime. Moreover, it is proved that a chronological spacetime in which the closure of the causal relation is transitive (for instance a reflective spacetime) admits a semi-time function. Along the way a new proof avoiding smoothing techniques is given that the existence of a time function implies stable causality, and a new short proof of the equivalence between K-causality and stable causality is given which takes advantage of Levin’s theorem and smoothing techniques.

  7. Tribal Utility Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Engel, R. A.; Zoellick, J. J.

    2007-06-30

    The Schatz Energy Research Center (SERC) assisted the Yurok Tribe in investigating the feasibility of creating a permanent energy services program for the Tribe. The original purpose of the DOE grant that funded this project was to determine the feasibility of creating a full-blown Yurok Tribal electric utility to buy and sell electric power and own and maintain all electric power infrastructure on the Reservation. The original project consultant found this opportunity to be infeasible for the Tribe. When SERC took over as project consultant, we took a different approach. We explored opportunities for the Tribe to develop its own renewable energy resources for use on the Reservation and/or off-Reservation sales as a means of generating revenue for the Tribe. We also looked at ways the Tribe can provide energy services to its members and how to fund such efforts. We identified opportunities for the development of renewable energy resources and energy services on the Yurok Reservation that fall into five basic categories: • Demand-side management – This refers to efforts to reduce energy use through energy efficiency and conservation measures. • Off-grid, facility and household scale renewable energy systems – These systems can provide electricity to individual homes and Tribal facilities in areas of the Reservation that do not currently have access to the electric utility grid. • Village scale, micro-grid renewable energy systems - These are larger scale systems that can provide electricity to interconnected groups of homes and Tribal facilities in areas of the Reservation that do not have access to the conventional electric grid. This will require the development of miniature electric grids to serve these interconnected facilities. • Medium to large scale renewable energy development for sale to the grid – In areas where viable renewable energy resources exist and there is access to the conventional electric utility grid, these resources can be

  8. Social group utility maximization

    CERN Document Server

    Gong, Xiaowen; Yang, Lei; Zhang, Junshan

    2014-01-01

    This SpringerBrief explains how to leverage mobile users' social relationships to improve the interactions of mobile devices in mobile networks. It develops a social group utility maximization (SGUM) framework that captures diverse social ties of mobile users and diverse physical coupling of mobile devices. Key topics include random access control, power control, spectrum access, and location privacy.This brief also investigates SGUM-based power control game and random access control game, for which it establishes the socially-aware Nash equilibrium (SNE). It then examines the critical SGUM-b

  9. MUNI-FITS-Utils

    Science.gov (United States)

    Chrastina, M.; Zejda, M.; Mikulášek, Z.

    2010-12-01

    The FITS standard allows arbitrary use of name-space for keywords, except some reserved keywords. Result of this freedom is that several keywords have the same meaning. Similar problem is that values of keywords have different physical units. These facts complicate automated data processing and also creation of FITS file archives with simple structure. MUNI-FITS-Utils is a package of Python scripts which have been developed in PyFITS, a Python FITS Module. Scripts are user-friendly and allow manipulating FITS headers to get uniform shape. Further functions will be added soon.

  10. Utilization of coalbed methane

    Energy Technology Data Exchange (ETDEWEB)

    Gustavson, J.B. [Gustavson Associates Inc., Boulder, CO (United States)

    1996-02-01

    Substantial progress has been made in capturing coalbed methane (CBM gas), which constitutes a valuable source of clean burning energy. It is of importance to study the various potential uses of coalbed methane and to understand the various technologies required, as well as their economics and any institutional constraints. In industrialised countries, the uses of coalbed methane are almost solely dependent on microeconomics; coalbed methane must compete for a market against natural gas and other energy sources - and frequently, coalbed methane is not competitive against other energy sources. In developing countries, on the other hand, particularly where other sources of energy are in short supply, coalbed methane economics yield positive results. Here, constraints to development of CBM utilization are mainly lack of technology and investment capital. Sociological aspects such as attitude and cultural habits, may also have a strong negative influence. This paper outlines the economics of coalbed methane utilization, particularly its competition with natural gas, and touches upon the many different uses to which coalbed methane may be applied. 24 refs., 4 figs.

  11. Geothermal Resource Utilization

    Energy Technology Data Exchange (ETDEWEB)

    Lienau, Paul J.

    1998-01-03

    Man has utilized the natural heat of the earth for centuries. Worldwide direct use of geothermal currently amounts to about 7,000 MWt, as compared to 1,500 MWe, now being used for the generation of electricity. Since the early 1970s, dwindling domestic reservoirs of oil and gas, continued price escalation of oil on the world market and environmental concerns associated with coal and nuclear energy have created a growing interest in the use of geothermal energy in the United States. The Department of Energy goals for hydrothermal resources utilization in the United States, expressed in barrels of oil equivalent, is 50 to 90 million bbl/yr by 1985 and 350 to 900 million bbl/yr by the year 2000. This relatively clean and highly versatile resource is now being used in a multitude of diverse applications (e.g., space heating and cooling, vegetable dehydration, agriculture, aquaculture, light manufacturing), and other applications requiring a reliable and economic source of heat.

  12. Micrograin Superplasticity: Characteristics and Utilization

    Directory of Open Access Journals (Sweden)

    Farghalli A. Mohamed

    2011-07-01

    Full Text Available Micrograin Superplasticity refers to the ability of fine-grained materials (1 µm < d < 10 μm, where d is the grain size to exhibit extensive neck-free elongations during deformation at elevated temperatures. Over the past three decades, good progress has been made in rationalizing this phenomenon. The present paper provides a brief review on this progress in several areas that have been related to: (a the mechanical characteristics of micrograin superplasticity and their origin; (b the effect of impurity content and type on deformation behavior, boundary sliding, and cavitation during superplastic deformation; (c the formation of cavity stringers; (d dislocation activities and role during superplastic flow; and (e the utilization of superplasticity.

  13. Highly Efficient Full-Color Thermally Activated Delayed Fluorescent Organic Light-Emitting Diodes: Extremely Low Efficiency Roll-Off Utilizing a Host with Small Singlet-Triplet Splitting.

    Science.gov (United States)

    Zhang, Dongdong; Zhao, Chongguang; Zhang, Yunge; Song, Xiaozeng; Wei, Pengcheng; Cai, Minghan; Duan, Lian

    2017-02-08

    Numerous efforts have been devoted to boost the efficiency of thermally activated delayed fluorescence (TADF) devices; however, strategies to suppress the device efficiency roll-off are still in urgent need. Here, a general and effective approach to suppress the efficiency roll-off of TADF devices is proposed, that is, utilizing TADF materials as the hosts for TADF emitters. Bearing small singlet-triplet splitting (ΔEST) with donor and acceptor units, TADF materials as the hosts possess the potential to achieve matched frontier energy levels with the adjacent transporting layers, facilitating balanced charge injection as well as bipolar charge transport mobilities beneficial to the balanced charges transportation. Furthermore, an enhanced Förster energy transfer from the host to the dopant can be anticipated, helpful to reduce the exciton concentration. Based on the principles, a new TADF material based on indeno[2,1-b]carbazole/1,3,5-triazin derivation is synthesized and used as the universal host for the full-color TADF devices. Remarkable low efficiency roll-off was achieved with above 90% of the maximum external quantum efficiencies (EQEmax's) maintained even at a brightness of 2000 cd/m(2), along with EQEmax's of 23.2, 21.0, and 19.2% for orange, green, and sky-blue TADF devices, respectively. Through computational simulation, we identified the suppressed exciton annihilation rates compared with devices adopting conventional hosts. The state-of-the-art low efficiency roll-off of those TADF devices manifests the great potential of such host design strategy, paving an efficient strategy toward their practical application.

  14. A general classification of silicon utilizing organisms

    Science.gov (United States)

    Das, P.; Das, S.

    2010-12-01

    Silicon utilizing organisms may be defined as organisms with high silicon content (≥ 1% dry weight) and they can metabolize silicon with or without demonstrable silicon transporter genes (SIT) in them(Das,2010). Silicon is the second most abundant element in the lithosphere (27.70%) and it is as important as phosphorus and magnesium (0.03%) in the biota. Hydrated silica represents the second most abundant biogenic mineral after carbonate minerals. Silicon is accumulated and metabolized by some prokaryotes, and Si compounds can stimulate the growth of a range of fungi. It is well known that Si is essential for diatoms. In mammals, Si is considered an essential trace element, required in bone, cartilage and connective tissue formation, enzymatic activities and other metabolic processes. Silicon was suggested to act as a phosphoprotein effector in bone. In mammals, Si is also reported to positively influence the immune system and to be required for lymphocyte proliferation. The aqueous chemistry of Si is dominated by silicic acid at biological pH ranges. Monosilicic acid can form stable complexes with organic hydroxy-containing molecules . Biosilica also has been identified associated with various biomolecules including proteins and carbohydrates. There are main seven groups of silicon utilizing organisms belonging to Gram positive bacteria, algae, protozoa, sponges, fungi, lichens, and monocotyledon plants. In each group again all the members are not silicon utilizing organisms, thus selective members in each group are further classified depending their degree of silicon utilization. Important silicon utilizing bacteria are Mycobacteria, Nocardia, Streptomyces, Staphylococcus, Bacillus, Lactobacillus spp. etc., Important silicon utilizing algae are Centrobacillariophyceae, Pennatibacillariophyceae and Chrysophyceae. Many protozoa belonging to Heterokonta, Choanoflagellida, Actinopoda are well known silicon utilizing microorganisms. Hexactinellida ( glass sponges

  15. Asteroid exploration and utilization

    Science.gov (United States)

    Radovich, Brian M.; Carlson, Alan E.; Date, Medha D.; Duarte, Manny G.; Erian, Neil F.; Gafka, George K.; Kappler, Peter H.; Patano, Scott J.; Perez, Martin; Ponce, Edgar

    1992-01-01

    The Earth is nearing depletion of its natural resources at a time when human beings are rapidly expanding the frontiers of space. The resources possessed by asteroids have enormous potential for aiding and enhancing human space exploration as well as life on Earth. Project STONER (Systematic Transfer of Near Earth Resources) is based on mining an asteroid and transporting raw materials back to Earth. The asteroid explorer/sample return mission is designed in the context of both scenarios and is the first phase of a long range plan for humans to utilize asteroid resources. Project STONER is divided into two parts: asteroid selection and explorer spacecraft design. The spacecraft design team is responsible for the selection and integration of the subsystems: GNC, communications, automation, propulsion, power, structures, thermal systems, scientific instruments, and mechanisms used on the surface to retrieve and store asteroid regolith. The sample return mission scenario consists of eight primary phases that are critical to the mission.

  16. Hydrogen and energy utilities

    Energy Technology Data Exchange (ETDEWEB)

    Hustadt, Daniel [Vattenfall Europe Innovation GmbH (Germany)

    2010-07-01

    Renewable electricity generation plays one major role with the biggest share being wind energy. At the end of the year 2009 a wind power plant capacity of around 26 GW was installed in Germany. Several outlooks come to the conclusion that this capacity can be doubled in ten years (compare Figure 1). Additionally the German government has set a target of 26 GW installed off-shore capacity in North and Baltic Sea until 2030. At Vattenfall only a minor percentage of the electricity production comes from wind power today. This share will be increased up to 12% until 2030 following Vattenfall's strategy 'Making Electricity Clean'. This rapid development of wind power offers several opportunities but also means some challenges to Utilities. (orig.)

  17. Utilize Vacuum Forming to Make Interdisciplinary Connections

    Science.gov (United States)

    Love, Tyler S.; Valenza, Frank

    2011-01-01

    The concept of vacuum forming has been around since the 19th century, despite not being fully utilized in industry until the 1950s. In the past, industrial arts classes have used vacuum-forming projects to concentrate solely on the manufacturing process and the final product. However, vacuum forming is not just an old industrial arts activity; it…

  18. Utility-Based HTN Planning

    NARCIS (Netherlands)

    Georgievski, Ilche; Lazovik, Alexander

    2014-01-01

    We propose the use of HTN planning for risk-sensitive planning domains. We suggest utility functions that reflect the risk attitude of compound tasks, and adapt a best-first search algorithm to take such utilities into account.

  19. Iranian nurses' constraint for research utilization

    Directory of Open Access Journals (Sweden)

    Mehrdad Neda

    2009-09-01

    Full Text Available Abstract Background This paper identifies the views of Iranian clinical nurses regarding the utilization of nursing research in practice. There is a need to understand what restricts Iranian clinical nurses to use research findings. The aim of this study was to identify practicing nurses' view of aspects which they perceived constrain them from research utilization that summarizes and uses research findings to address a nursing practice problem. Methods Data were collected during 6 months by means of face-to face interviews follow by one focus group. Analysis was undertaken using a qualitative content analysis. Results Findings disclosed some key themes perceived by nurses to restrict them to use research findings: level of support require to be research active, to be research minded, the extent of nurses knowledge and skills about research and research utilization, level of educational preparation relating to using research, administration and executive challenges in clinical setting, and theory-practice gap. Conclusion This study identifies constraints that require to be overcome for clinical nurses to actively get involved in research utilization. In this study nurses were generally interested to use research findings. However they felt restricted because of lack of time, lack of peer and manager support and limited knowledge and skills of the research process. This study also confirms that research utilization and the change to research nursing practice are complex issues which require both organizational and educational efforts.

  20. Scoping study of integrated resource planning needs in the public utility sector

    Energy Technology Data Exchange (ETDEWEB)

    Garrick, C J; Garrick, J M; Rue, D R [NEOS Corp., Lakewood, CO (United States)

    1993-06-01

    Integrated resource planning (IRP) is an approach to utility resource planning that integrates the evaluation of supply- and demand-site options for providing energy services at the least cost. Many utilities practice IRP; however, most studies about IRP focus on investor-owned utilities (IOUs). This scoping study investigates the IRP activities and needs of public utilities (not-for-profit utilities, including federal, state, municipal, and cooperative utilities). This study (1) profiles IRP-related characteristics of the public utility sector, (2) articulates the needs of public utilities in understanding and implementing IRP, and (3) identifies strategies to advance IRP principles in public utility planning.

  1. Utilization management in anatomic pathology.

    Science.gov (United States)

    Lewandrowski, Kent; Black-Schaffer, Steven

    2014-01-01

    There is relatively little published literature concerning utilization management in anatomic pathology. Nonetheless there are many utilization management opportunities that currently exist and are well recognized. Some of these impact only the cost structure within the pathology department itself whereas others reduce charges for third party payers. Utilization management may result in medical legal liabilities for breaching the standard of care. For this reason it will be important for pathology professional societies to develop national utilization guidelines to assist individual practices in implementing a medically sound approach to utilization management.

  2. Liquefaction chemistry and kinetics: Hydrogen utilization studies

    Energy Technology Data Exchange (ETDEWEB)

    Rothenberger, K.S.; Warzinski, R.P.; Cugini, A.V. [Pittsburgh Energy Technology Center, PA (United States)] [and others

    1995-12-31

    The objectives of this project are to investigate the chemistry and kinetics that occur in the initial stages of coal liquefaction and to determine the effects of hydrogen pressure, catalyst activity, and solvent type on the quantity and quality of the products produced. The project comprises three tasks: (1) preconversion chemistry and kinetics, (2) hydrogen utilization studies, and (3) assessment of kinetic models for liquefaction. The hydrogen utilization studies work will be the main topic of this report. However, the other tasks are briefly described.

  3. Gas utilization technologies

    Energy Technology Data Exchange (ETDEWEB)

    Biljetina, R.

    1994-09-01

    One of the constant challenges facing the research community is the identification of technology needs 5 to 15 years from now. A look back into history indicates that the forces driving natural gas research have changed from decade to decade. In the 1970s research was driven by concerns for adequate supply; in the 1980s research was aimed at creating new markets for natural gas. What then are the driving forces for the 1990s? Recent reports from the natural gas industry have helped define a new direction driven primarily by market demand for natural gas. A study prepared by the Interstate Natural Gas Association of America Foundation entitled ``Survey of Natural Research, Development, and Demonstration RD&D Priorities`` indicated that in the 1990s the highest research priority should be for natural gas utilization and that technology development efforts should not only address efficiency and cost, but environmental and regulatory issues as well. This study and others, such as the report by the American Gas Association (A.G.A.) entitled ``Strategic Vision for Natural Gas Through the Year 2000,`` clearly identify the market sectors driving today`s technology development needs. The biggest driver is the power generation market followed by the industrial, transportation, appliance, and gas cooling markets. This is best illustrated by the GRI 1994 Baseline Projection on market growth in various sectors between the year 1992 and 2010. This paper highlights some of the recent technology developments in each one of these sectors.

  4. Molecular mechanisms of thiamine utilization.

    Science.gov (United States)

    Singleton, C K; Martin, P R

    2001-05-01

    Thiamine is required for all tissues and is found in high concentrations in skeletal muscle, heart, liver, kidneys and brain. A state of severe depletion is seen in patients on a strict thiamine-deficient diet in 18 days, but the most common cause of thiamine deficiency in affluent countries is alcoholism. Thiamine diphosphate is the active form of thiamine, and it serves as a cofactor for several enzymes involved primarily in carbohydrate catabolism. The enzymes are important in the biosynthesis of a number of cell constituents, including neurotransmitters, and for the production of reducing equivalents used in oxidant stress defenses and in biosyntheses and for synthesis of pentoses used as nucleic acid precursors. Because of the latter fact, thiamine utilization is increased in tumor cells. Thiamine uptake by the small intestines and by cells within various organs is mediated by a saturable, high affinity transport system. Alcohol affects thiamine uptake and other aspects of thiamine utilization, and these effects may contribute to the prevalence of thiamine deficiency in alcoholics. The major manifestations of thiamine deficiency in humans involve the cardiovascular (wet beriberi) and nervous (dry beriberi, or neuropathy and/or Wernicke-Korsakoff syndrome) systems. A number of inborn errors of metabolism have been described in which clinical improvements can be documented following administration of pharmacological doses of thiamine, such as thiamine-responsive megaloblastic anemia. Substantial efforts are being made to understand the genetic and biochemical determinants of inter-individual differences in susceptibility to development of thiamine deficiency-related disorders and of the differential vulnerabilities of tissues and cell types to thiamine deficiency.

  5. Facility Utilization Reports -  FAA Aviation Information Utilization Reports

    Data.gov (United States)

    Department of Transportation — Provides: (1) Space management and planning, including area calculations, tracking space by organization and employee, and monitoring space utilization information....

  6. Not utilized learning potentials

    DEFF Research Database (Denmark)

    Kragelund, Linda

    -conscious disjuncture, in development of the concept pseudo-everyday life activities and in a categorizing mo­del for and a theory about student nurses' learning processes. The theory includes relations between 4 types of  disjuncture, 3 types of content in the learning processes, and factors that provoke......  When the Danish Nursing Education in 2002 became a Bachelor Degree the clinical part of the education was reduced. Therefore, it was necessary to optimize learning in practice.       I made a qualitative investigation to describe student nurses' learning processes in non-routine situations where...... transformation from one type of disjuncture to another.      Students and mentors are not aware that students are in potential learning situations when they interact on their own with patients, and that it is non-routine for students to act with patients in pseudo-everyday life activities. It may be possible...

  7. Utility Computing: Reality and Beyond

    Science.gov (United States)

    Ivanov, Ivan I.

    Utility Computing is not a new concept. It involves organizing and providing a wide range of computing-related services as public utilities. Much like water, gas, electricity and telecommunications, the concept of computing as public utility was announced in 1955. Utility Computing remained a concept for near 50 years. Now some models and forms of Utility Computing are emerging such as storage and server virtualization, grid computing, and automated provisioning. Recent trends in Utility Computing as a complex technology involve business procedures that could profoundly transform the nature of companies' IT services, organizational IT strategies and technology infrastructure, and business models. In the ultimate Utility Computing models, organizations will be able to acquire as much IT services as they need, whenever and wherever they need them. Based on networked businesses and new secure online applications, Utility Computing would facilitate "agility-integration" of IT resources and services within and between virtual companies. With the application of Utility Computing there could be concealment of the complexity of IT, reduction of operational expenses, and converting of IT costs to variable `on-demand' services. How far should technology, business and society go to adopt Utility Computing forms, modes and models?

  8. Supplier Selection Using Weighted Utility Additive Method

    Science.gov (United States)

    Karande, Prasad; Chakraborty, Shankar

    2015-10-01

    Supplier selection is a multi-criteria decision-making (MCDM) problem which mainly involves evaluating a number of available suppliers according to a set of common criteria for choosing the best one to meet the organizational needs. For any manufacturing or service organization, selecting the right upstream suppliers is a key success factor that will significantly reduce purchasing cost, increase downstream customer satisfaction and improve competitive ability. The past researchers have attempted to solve the supplier selection problem employing different MCDM techniques which involve active participation of the decision makers in the decision-making process. This paper deals with the application of weighted utility additive (WUTA) method for solving supplier selection problems. The WUTA method, an extension of utility additive approach, is based on ordinal regression and consists of building a piece-wise linear additive decision model from a preference structure using linear programming (LP). It adopts preference disaggregation principle and addresses the decision-making activities through operational models which need implicit preferences in the form of a preorder of reference alternatives or a subset of these alternatives present in the process. The preferential preorder provided by the decision maker is used as a restriction of a LP problem, which has its own objective function, minimization of the sum of the errors associated with the ranking of each alternative. Based on a given reference ranking of alternatives, one or more additive utility functions are derived. Using these utility functions, the weighted utilities for individual criterion values are combined into an overall weighted utility for a given alternative. It is observed that WUTA method, having a sound mathematical background, can provide accurate ranking to the candidate suppliers and choose the best one to fulfill the organizational requirements. Two real time examples are illustrated to prove

  9. Information security becoming a priority for utilities

    Energy Technology Data Exchange (ETDEWEB)

    Nicolaides, S. [Numerex, Atlanta, GA (United States)

    2009-10-15

    As part of North America's national critical infrastructure, utilities are finding themselves at the forefront of a security issue. In October 2007, a leading security service provider reported a 90 per cent increase in the number of hackers attempting to attack its utility clients in just one year. Utilities are vulnerable to cyber attacks that could disrupt power production and the transmission system. This article discussed the need for intelligent technologies in securely enabling resource management and operational efficiency of the utilities market. It discussed the unique security challenges that utilities face at a time of greater regulatory activity, heightened environmental concerns, tighter data security requirements and an increasing need for remote monitoring and control. A new tool has emerged for cyber security in the form of an international standard that may offer a strong guideline to work toward 11 security domains. These include security policy; organization of information security; asset management; human resources security; physical and environmental security; communications and operations management; access control; information systems acquisition; development and maintenance; information security incident management; business continuity management; and compliance. 2 figs.

  10. Electric utility industry and planning

    Energy Technology Data Exchange (ETDEWEB)

    Schiffman, Y. (ed.)

    1983-01-01

    The objective of the workshop reported in these proceedings was to bring together planners, public officials, and community leaders with members of the utility industry to learn about utilities and to permit a meaningful exchange of information. This workshop was held at the Annual Meeting of the American Planning Association and its Energy Planning Division. The workshop was designed to inform planners about the electric-utility industry. A separate abstract was prepared for each of 4 individual presentations.

  11. VT Electric Utility Franchise Areas

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) ELCFRANCHISE includes Vermont's Electric Utility Franchise boundaries. It is a compilation of many data sources. The boundaries are approximate...

  12. Confidential data in a competitive utility environment: A regulatory perspective

    Energy Technology Data Exchange (ETDEWEB)

    Vine, E.

    1996-08-01

    Historically, the electric utility industry has been regarded as one of the most open industries in the United States in sharing information but their reputation is being challenged by competitive energy providers, the general public, regulators, and other stakeholders. As the prospect of competition among electricity power providers has increased in recent years, many utilities have been requesting that the data they submit to their utility regulatory commissions remain confidential. Withholding utility information from the public is likely to have serious and significant policy implications with respect to: (1) consumer education, the pursuit of truth, mutual respect among parties, and social cooperation; (2) the creation of a fair market for competitive energy services; (3) the regulatory balance; (4) regional and national assessments of energy-savings opportunities; (5) research and development; and (6) evaluations of utility programs, plans, and policies. In a telephone survey of all public utility commissions (PUCs) that regulate electric and gas utilities in the U.S., we found that almost all PUCs have received requests from utility companies for data to be filed as confidential, and confidential data filings appear to have increased (both in scope and in frequency) in those states where utility restructuring is being actively discussed. The most common types of data submitted as confidential by utilities dealt with specific customer data, market data, avoided costs, and utility costs.

  13. Fly ash quality and utilization

    Energy Technology Data Exchange (ETDEWEB)

    Barta, L.E.; Lachner, L.; Wenzel, G.B. [Inst. for Energy, Budapest (Hungary); Beer, M.J. [Massachusetts Inst. of Technology, Cambridge, MA (United States)

    1995-12-01

    The quality of fly ash is of considerable importance to fly ash utilizers. The fly ash puzzolanic activity is one of the most important properties that determines the role of fly ash as a binding agent in the cementing process. The puzzolanic activity, however is a function of fly ash particle size and chemical composition. These parameters are closely related to the process of fly ash formation in pulverized coal fired furnaces. In turn, it is essential to understand the transformation of mineral matter during coal combustion. Due to the particle-to-particle variation of coal properties and the random coalescence of mineral particles, the properties of fly ash particles e.g. size, SiO{sub 2} content, viscosity can change considerably from particle to particle. These variations can be described by the use of the probability theory. Since the mean values of these randomly changing parameters are not sufficient to describe the behavior of individual fly ash particles during the formation of concrete, therefore it is necessary to investigate the distribution of these variables. Examples of these variations were examined by the Computer Controlled Scanning Electron Microscopy (CCSEM) for particle size and chemical composition for Texas lignite and Eagel Butte mineral matter and fly ash. The effect of combustion on the variations of these properties for both the fly ash and mineral matter were studied by using a laminar flow reactor. It is shown in our paper, that there are significant variations (about 40-50% around the mean values) of the above-listed properties for both coal samples. By comparing the particle size and chemical composition distributions of the mineral matter and fly ash, it was possible to conclude that for the Texas lignite mineral matter, the combustion did not effect significantly the distribution of these properties, however, for the Eagel Butte coal the combustion had a major impact on these mineral matter parameters.

  14. Reflections on Improvement of Utility Model System in China

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Even since 1985 when the Patent Law was launched in China, the utility model patent has been playing a very important role. Over the two decades, the utility model system has played an active part in encouraging invention-creations, and promoting the progress and development of science and technology.

  15. The Evaluator's Responsibility for Utilization.

    Science.gov (United States)

    Patton, Michael Quinn

    1988-01-01

    The role of the evaluator in insuring utilization and quality of evaluation results is discussed. Topics covered include a utilization-focused vision of accountability, overcoming staff fears of evaluation, eliciting the right information from users, situational responsiveness, and advocacy. (TJH)

  16. Utility supply portfolio diversity requirements

    Energy Technology Data Exchange (ETDEWEB)

    Hanser, Philip; Graves, Frank

    2007-06-15

    In general, diversification for its own sake by utilities is likely to come at significant cost from ignoring or having to overcome engineering reasons for preferring a less diversified portfolio of resources. Integrated utilities, distcos and merchant gencos are likely to pursue widely divergent strategies in this regard. (author)

  17. Utility photovoltaic group: Status report

    Science.gov (United States)

    Serfass, Jeffrey A.; Hester, Stephen L.; Wills, Bethany N.

    1996-01-01

    The Utility PhotoVoltaic Group (UPVG) was formed in October of 1992 with a mission to accelerate the use of cost-effective small-scale and emerging grid-connected applications of photovoltaics for the benefit of electric utilities and their customers. The UPVG is now implementing a program to install up to 50 megawatts of photovoltaics in small-scale and grid-connected applications. This program, called TEAM-UP, is a partnership of the U.S. electric utility industry and the U.S. Department of Energy to help develop utility PV markets. TEAM-UP is a utility-directed program to significantly increase utility PV experience by promoting installations of utility PV systems. Two primary program areas are proposed for TEAM-UP: (1) Small-Scale Applications (SSA)—an initiative to aggregate utility purchases of small-scale, grid-independent applications; and (2) Grid-Connected Applications (GCA)—an initiative to identify and competitively award cost-sharing contracts for grid-connected PV systems with high market growth potential, or collective purchase programs involving multiple buyers. This paper describes these programs and outlines the schedule, the procurement status, and the results of the TEAM-UP process.

  18. Xylose utilization in recombinant Zymomonas

    Science.gov (United States)

    Kahsay, Robel Y; Qi, Min; Tao, Luan; Viitanen, Paul V; Yang, Jianjun

    2013-01-07

    Zymomonas expressing xylose isomerase from A. missouriensis was found to have improved xylose utilization, growth, and ethanol production when grown in media containing xylose. Xylose isomerases related to that of A. missouriensis were identified structurally through molecular phylogenetic and Profile Hidden Markov Model analyses, providing xylose isomerases that may be used to improve xylose utilization.

  19. Utilizing Fractal Time

    Science.gov (United States)

    Marks-Tarlow, Terry

    Linear concepts of time plus the modern capacity to track history emerged out of circular conceptions characteristic of ancient and traditional cultures. A fractal concept of time lies implicitly within the analog clock, where each moment is treated as unique. With fractal geometry the best descriptor of nature, qualities of self-similarity and scale invariance easily model her endless variety and recursive patterning, both in time and across space. To better manage temporal aspects of our lives, a fractal concept of time is non-reductive, based more on the fullness of being than on fragments of doing. By using a fractal concept of time, each activity or dimension of life is multiply and vertically nested. Each nested cycle remains simultaneously present, operating according to intrinsic dynamics and time scales. By adding the vertical axis of simultaneity to the horizontal axis of length, time is already full and never needs to be filled. To attend to time's vertical dimension is to tap into the imaginary potential for infinite depth. To switch from linear to fractal time allows us to relax into each moment while keeping in mind the whole.

  20. Information-Seeking, Research Utilization, and Barriers to Research Utilization of Pediatric Nurse Educators.

    Science.gov (United States)

    Barta, Kathleen M.

    1995-01-01

    Responses from 52% of 409 pediatric nurse educators identified 3 top information sources for updating instruction: nursing journals, professional education activities, and texts. Level of research utilization measured by Nursing Practice Questionnaire-Education for eight nursing practices was the implementation stage. Those using nursing journals…

  1. U.S. electric utility demand-side management 1993

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    This report presents comprehensive information on electric power industry demand-side management activities in the United States at the national, regional, and utility levels. Data is included for energy savings, peakload reductions, and costs.

  2. Lunar All-Terrain Utility Vehicle for EVA Project

    Data.gov (United States)

    National Aeronautics and Space Administration — ProtoInnovations, LLC proposes to develop a new type of planetary rover called a Lunar All-terrain Utility Vehicle ("Lunar ATV") to assist extra-vehicular activities...

  3. Lunar All-Terrain Utility Vehicle for EVA Project

    Data.gov (United States)

    National Aeronautics and Space Administration — ProtoInnovations, LLC proposes to develop a new type of planetary rover called a Lunar All-terrain Utility Vehicle ("LATUV") to assist extra-vehicular activities in...

  4. U.S. electric utility demand-side management 1993

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    This report presents comprehensive information on electric power industry demand-side management activities in the United States at the national, regional, and utility levels. Data is included for energy savings, peakload reductions, and costs.

  5. Hualapai Tribal Utility Development Project

    Energy Technology Data Exchange (ETDEWEB)

    Hualapai Tribal Nation

    2008-05-25

    The first phase of the Hualapai Tribal Utility Development Project (Project) studied the feasibility of establishing a tribally operated utility to provide electric service to tribal customers at Grand Canyon West (see objective 1 below). The project was successful in completing the analysis of the energy production from the solar power systems at Grand Canyon West and developing a financial model, based on rates to be charged to Grand Canyon West customers connected to the solar systems, that would provide sufficient revenue for a Tribal Utility Authority to operate and maintain those systems. The objective to establish a central power grid over which the TUA would have authority and responsibility had to be modified because the construction schedule of GCW facilities, specifically the new air terminal, did not match up with the construction schedule for the solar power system. Therefore, two distributed systems were constructed instead of one central system with a high voltage distribution network. The Hualapai Tribal Council has not taken the action necessary to establish the Tribal Utility Authority that could be responsible for the electric service at GCW. The creation of a Tribal Utility Authority (TUA) was the subject of the second objective of the project. The second phase of the project examined the feasibility and strategy for establishing a tribal utility to serve the remainder of the Hualapai Reservation and the feasibility of including wind energy from a tribal wind generator in the energy resource portfolio of the tribal utility (see objective 2 below). It is currently unknown when the Tribal Council will consider the implementation of the results of the study. Objective 1 - Develop the basic organizational structure and operational strategy for a tribally controlled utility to operate at the Tribe’s tourism enterprise district, Grand Canyon West. Coordinate the development of the Tribal Utility structure with the development of the Grand Canyon

  6. Utilization of carbohydrates by radiation processing

    Energy Technology Data Exchange (ETDEWEB)

    Kume, T. E-mail: kume@taka.jaeri.go.jp; Nagasawa, N.; Yoshii, F

    2002-03-01

    Upgrading and utilization of carbohydrates such as chitosan, sodium alginate, carrageenan, cellulose, pectin have been investigated for recycling these bio-resources and reducing the environmental pollution. These carbohydrates were easily degraded by irradiation and various kinds of biological activities such as anti-microbial activity, promotion of plant growth, suppression of heavy metal stress, phytoalexins induction, etc. were induced. On the other hand, some carbohydrate derivatives, carboxymethylcellulose and carboxymethylstarch, could be crosslinked under certain radiation condition and produce the biodegradable hydrogel for medical and agricultural use.

  7. Geothermal direct-heat utilization assistance

    Science.gov (United States)

    The report summarizes activities of the Geo-Heat Center (GHC) at Oregon Institute of Technology for the first quarter of Fiscal Year 1995. It describes contacts with parties during this period related to assistance with geothermal direct heat projects. Areas dealt with include geothermal heat pumps, space heating, greenhouses, aquaculture, resources and equipment. Research is also being conducted on geothermal energy cost evaluation, low-temperature geothermal resource assessment, use of silica waste from the Cerro Prieto geothermal field as construction materials and geothermal heat pumps. Outreach activities include the publication of a quarterly bulletin on direct heat applications and dissemination of information on low-temperature geothermal resources and utilization.

  8. EERC Center for Biomass Utilization 2006

    Energy Technology Data Exchange (ETDEWEB)

    Zygarlicke, Christopher J. [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center; Hurley, John P. [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center; Aulich, Ted R. [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center; Folkedahl, Bruce C. [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center; Strege, Joshua R. [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center; Patel, Nikhil [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center; Shockey, Richard E. [Univ. of North Dakota, Grand Forks, ND (United States). Energy and Environmental Research Center

    2009-05-27

    The Center for Biomass Utilization® 2006 project at the Energy & Environmental Research Center (EERC) consisted of three tasks related to applied fundamental research focused on converting biomass feedstocks to energy, liquid transportation fuels, and chemicals. Task 1, entitled Thermochemical Conversion of Biomass to Syngas and Chemical Feedstocks, involved three activities. Task 2, entitled Crop Oil Biorefinery Process Development, involved four activities. Task 3, entitled Management, Education, and Outreach, focused on overall project management and providing educational outreach related to biomass technologies through workshops and conferences.

  9. Politics of public utility regulation

    Energy Technology Data Exchange (ETDEWEB)

    Gormley, W.T. Jr.

    1983-01-01

    Since the early 1970s, energy and telecommunications policies have emerged as increasingly complex and conflictual issues in state government and have, consequently, brought about change in the politics of public utilities regulation. In this analysis, Gormley shows that state public utilities commissions, in determining the rates that can be charged by private utility companies, must confront elected government officials, members of the state bureaucracy, citizens' groups, and the regulated industries themselves in a very visible, highly technical, costly, and controversial process that pits investors against consumers, business groups against residential consumers, consumer groups against environmentalists, and low-income consumers against consumers as a whole.

  10. Silicon Utilizing Microbial Bioactivities in the Biosphere

    Science.gov (United States)

    Sen, M. M.; Das, S.

    2012-12-01

    Diatoms are unicellular eukaryotic algae and an important member of the silicon utilizing organisms, that generate ~20% of the ~100 billion metric tons of organic carbon produced through photosynthesis on Earth each year. Fragilariopsis is a dominating psychrophilic diatom genus in polar sea ice. The two species Fragilariopsis cylindrus and Fragilariopsis curta are able to grow and divide below freezing temperature. Antifreeze proteins (AFPs), involved in cold adaptation in several psychrophilic organisms, are widespread in this two polar species. Achanthes minutissima isolated as dominant diatom has degradable effects involving petroleum hydocarbons. Phaeodactylum tricornutum, have antibacterial activity and the fatty acid, eicosapentaenoic acid (EPA), has been identified as one compound responsible for this activity. Other antibacterial compounds are monounsaturated fatty acid (9Z)-hexadecenoic acid (palmitoleic acid; C16:1 n-7) and the relatively unusual polyunsaturated fatty acid (6Z, 9Z, 12Z)-hexadecatrienoic acid (HTA; C16:3 n-4). Both are active against Gram-positive bacteria and many Gram-negative pathogen. Palmitoleic acid is active at micro-molar concentrations, kills bacteria rapidly, and is highly active against multidrug-resistant Staphylococcus aureus. Domoic acid -a neurotoxin produced by Pseudo-nitzschia accumulates in marine invertebrates. Evidences of sea lion (Zalophus californianus) and human poisoning following consumption of contaminated blue mussels (Mytilus edulis) is mainly due to this toxin. Among the most prominent features described in human beings was memory impairment which led to the name Amnesic Shellfish Poisoning [ASP]. Silicon utilizing organisms can act as a bioindicator of environmental contamination, thus a rapid change in phytochelatins to both the increase in and the withdrawal of environmental Cd stress was found in Thalassiosira nordenskioeldii. Some of them also can produce biofuels particularly diatoms have significant

  11. State Drug Utilization Data 2013

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  12. State Drug Utilization Data 2012

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  13. State Drug Utilization Data 2001

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  14. State Drug Utilization Data 2000

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  15. State Drug Utilization Data 2008

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  16. State Drug Utilization Data 2003

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  17. State Drug Utilization Data 1999

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  18. State Drug Utilization Data 2009

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  19. State Drug Utilization Data 2011

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  20. State Drug Utilization Data 2014

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  1. State Drug Utilization Data 1994

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  2. State Drug Utilization Data 1991

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  3. State Drug Utilization Data 1995

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  4. State Drug Utilization Data 1993

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  5. State Drug Utilization Data 2004

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  6. State Drug Utilization Data 1992

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  7. State Drug Utilization Data 1997

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  8. State Drug Utilization Data 2005

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  9. State Drug Utilization Data 1996

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  10. State Drug Utilization Data 1998

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  11. State Drug Utilization Data 2006

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  12. State Drug Utilization Data 2010

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  13. State Drug Utilization Data 2007

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  14. State Drug Utilization Data 2002

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  15. State Drug Utilization Data 2016

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  16. Medicare Utilization for Part B

    Data.gov (United States)

    U.S. Department of Health & Human Services — This link takes you to the Medicare utilization statistics for Part B (Supplementary Medical Insurance SMI) which includes the Medicare Part B Physician and Supplier...

  17. Medicare Utilization for Part A

    Data.gov (United States)

    U.S. Department of Health & Human Services — This link takes you to the Medicare utilization statistics for Part A (Hospital Insurance HI) which include the Medicare Ranking for all Short-Stay Hospitals by...

  18. US Forest Service Land Utilization

    Data.gov (United States)

    US Forest Service, Department of Agriculture — A map service on the www depicting units designated by the Secretary of Agriculture for conservation and utilization under Title III of the Bankhead-Jones Farm...

  19. State Drug Utilization Data 2015

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  20. Growth of hydrocarbon utilizing microorganisms

    Digital Repository Service at National Institute of Oceanography (India)

    Bhosle, N.B.; Mavinkurve, S.

    Two isolates from marine mud having broad spectrum hydrocarbon utilizing profile were identified as Arthrobacter simplex and Candida tropicalis.Both the organisms grew exponentially on crude oil. The cell yield of the organisms was influenced...

  1. Cloud Computing Utility and Applications

    Directory of Open Access Journals (Sweden)

    Pradeep Kumar Tiwari

    2011-12-01

    Full Text Available Cloud Architecture provides services on demand basis via internet (WWW services. Application design in cloud computing environment or the applications which support cloud paradigm are on demand on the basis of user requirement. Those applications provide the support on various hardware, software and other resource requirement on demand. API used in the cloud computing provide the greater advantage to provide industrial strength, where the complex reliability and scalability logic of the underlying services remains implemented and hidden in the cloud environment. Cloud Computing provide the highest utilization in terms of utilization, resource sharing, requirement gathering and utility to the other needful resources. In this paper we discuss several utility and their applications. We provide a broad discussion which is useful for cloud computing research.

  2. State Drug Utilization Data 2017

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  3. Industrial utilization of geopressured geothermal energy

    Energy Technology Data Exchange (ETDEWEB)

    Underhill, Gary K; Carlson, Ronald A.; Clendinning, William A.; Erdos, Jozsef; Gault, John; Hall, James W.; Jones, Robert L.; Michael, Herbert K.; Powell, Paul H.; Riemann, Carl F.; Rios-Castellon, Lorenzo; Shepherd, Burchard P.; Wilson, John S.

    1976-01-01

    Discussion of the industrial utilization of geopressured geothermal energy is currently limited by the limited knowledge of the resource's distribution. However, the resource assessment activity in the Bureau of Economic Geology, The University of Texas at Austin, has identified a number of fairway or potential resource zones. These zones are located in Kenedy County; in and about Corpus Christi and Nueces Bays in Nueces, San Patricio, and Aransas Counties; in the coastal zones of Matagorda County; and in a crescent-shaped zone parallel to the coastline in Brazoria and Galveston Counties. The Kenedy and Matagorda County zones are situated in rural areas with little or no industrial activity. The Corpus Christi and Brazoria-Galveston zones are in and adjacent to highly industrialized and urbanized districts. The rural zones will require the establishment of new industries for geothermal fluid utilization while the industrial-urban zones will require either new industry, expansion to existing industry, or modification to existing plant and process. Proposed industries for geothermal fluid utilization can be considered with respect to fitting the industry to the available fluids; this has been the usual approach. An alternate approach is to fit the abailable fluids to the proposed industry. In order to follow the alternate approach requires consideration of ways to upgrade the quality of existing geothermal fluids or geothermal-derived or -energized fluids.

  4. Are CEOs Expected Utility Maximizers?

    OpenAIRE

    John List; Charles Mason

    2009-01-01

    Are individuals expected utility maximizers? This question represents much more than academic curiosity. In a normative sense, at stake are the fundamental underpinnings of the bulk of the last half-century's models of choice under uncertainty. From a positive perspective, the ubiquitous use of benefit-cost analysis across government agencies renders the expected utility maximization paradigm literally the only game in town. In this study, we advance the literature by exploring CEO's preferen...

  5. Lymphedema Prophylaxis Utilizing Perloperative Education

    Science.gov (United States)

    2005-09-01

    AD Award Number: DAMD17-00-1-0495 TITLE: Lymphedema Prophylaxis Utilizing Perloperative Education PRINCIPAL INVESTIGATOR: Mary Ann Kosir, M.D...NUMBER Lymphedema Prophylaxis Utilizing Perloperative Education 5b. GRANT NUMBER DAM D1 7-00-1-0495 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...perioperative training for lymphedema assessment and protection. The hypothesis is that structured perioperative training in lymphedema protection will

  6. Burnout and health care utilization.

    Science.gov (United States)

    Jackson, C N; Manning, M R

    1995-01-01

    This study explores the relationship between burnout and health care utilization of 238 employed adults. Burnout was measured by the Maslach Burnout Inventory and health care utilization by insurance company records regarding these employees' health care costs and number of times they accessed health care services over a one year period. ANOVAs were conducted using Golembiewski and Munzenrider's approach to define the burnout phase. Significant differences in health care costs were found.

  7. How expensive is link utilization?

    OpenAIRE

    Stanojević, Rade; Shorten, Robert

    2007-01-01

    Understanding the relationship between queueing delays and link utilization for general traffic conditions is an important open problem in networking research. Difficulties in understanding this relationship stem from the fact that it depends on the complex nature of arriving traffic and the problems associated with modelling such traffic. Existing AQM schemes achieve a "low delay" and "high utilization" by responding early to congestion without considering the exact relationship betwee...

  8. PROBLEMS OF UTILIZATION MANUFACTURABILITY OF MACHINES

    Directory of Open Access Journals (Sweden)

    Kokorev G. D.

    2016-05-01

    Full Text Available The article contains analysis of consumption of the main natural resources and their use in the automotive industry. It is noted that during the manufacture of the car pollution is obtained in 2 times more than in exploitation. It defines the essence of recycling process (autorecycling and its ecological components. Activity on autorecycling was expressed through the index of recycling efficiency. We have analyzed the global car fleet and average annual amount of automotive waste, million tons per year. We point out that one of the economic components of recycling is the use of parts and mechanisms of machines ready for further use, by qualitative technical diagnostics with use of diagnostics devices. The problem of utilization technological effectiveness of cars as set of the properties characterizing fitness of a design to utilization at the minimum costs of time, work, means, providing the minimum negative impact on environment and the maximum involvement of components of the written-off equipment in processing or a reuse is considered. The main definitions and factors defining utilization technological effectiveness and its main indicators are given. The main ways of increasing of utilization technological effectiveness of cars are offered and the conclusion is drawn that simplifying dismantling of the car on automobile components, reducing dismantle time, time of draining of everything, the liquids and oils applied at operation, applying environmentally friendly materials, etc., the designer can increase technological effectiveness of the car at utilization. As a result of the solved task we have got ecological and economic effect of vehicle recycling

  9. Analysis of Comprehensive Utilization of Coconut Waste

    Institute of Scientific and Technical Information of China (English)

    Kan; ZHENG; Dong; LIANG; Xirui; ZHANG

    2013-01-01

    This paper describes and analyzes the coconut cultivation in China,and the current comprehensive utilization of waste resources generated during cultivation and processing of coconut.The wastes generated in the process of cultivation include old coconut tree trunk,roots,withered coconut leaves,coconut flower and fallen cracking coconut,mainly used for biogas extraction,direct combustion and power generation,brewing,pharmacy,and processing of building materials;the wastes generated during processing include coconut water,coconut coat,coconut shell and coconut meal,mainly used for processing beverages,pharmaceutical products,activated carbon,medium and feed.This paper analyzes and explores some problems in the process of comprehensive utilization of coconut waste in China,such as insufficient understanding,inadequate development and lack of research efforts,and finally puts forth the corresponding development countermeasures.

  10. Microbial thiocyanate utilization under highly alkaline conditions.

    Science.gov (United States)

    Sorokin, D Y; Tourova, T P; Lysenko, A M; Kuenen, J G

    2001-02-01

    activity which converted cyanate (CNO-) to ammonia and CO2. On the other hand, cyanase activity either was absent or was present at very low levels in the autotrophic strains grown on thiocyanate as the sole energy and N source. As a result, large amounts of cyanate were found to accumulate in the media during utilization of thiocyanate at pH 10 in batch and thiocyanate-limited continuous cultures. This is a first direct proof of a "cyanate pathway" in pure cultures of thiocyanate-degrading bacteria. Since it is relatively stable under alkaline conditions, cyanate is likely to play a role as an N buffer that keeps the alkaliphilic bacteria safe from inhibition by free ammonia, which otherwise would reach toxic levels during dissimilatory degradation of thiocyanate.

  11. Design, synthesis and evaluation of novel 2-thiophen-5-yl-3H-quinazolin-4-one analogues as inhibitors of transcription factors NF-kappaB and AP-1 mediated transcriptional activation: Their possible utilization as anti-inflammatory and anti-cancer agents.

    Science.gov (United States)

    Giri, Rajan S; Thaker, Hardik M; Giordano, Tony; Williams, Jill; Rogers, Donna; Vasu, Kamala K; Sudarsanam, Vasudevan

    2010-04-01

    In an attempt to discover novel inhibitors of NF-kappaB and AP-1 mediated transcriptional activation utilizing the concept of chemical lead based medicinal chemistry and bioisosterism a series of 2-(2,3-disubstituted-thiophen-5-yl)-3H-quinazolin-4-one analogs was designed. A facile and simple route for the synthesis of the designed molecules was developed. Synthesized molecules were evaluated for their activity as inhibitors towards NF-kappaB and AP-1 mediated transcriptional activation in a cell line report-based assay. This series provides us with a substantial number of compounds inhibiting the activity of NF-kappaB and/or AP-1 mediated transcriptional activation. These compounds also exhibit anti-inflammatory and anti-cancer activity in in vivo models of inflammation and cancer. The 4-pyridyl group is found to be the most important pharmacophore on the third position of thiophene ring for inhibiting NF-kappaB and AP-1 mediated transcriptional activation. The relationships between the activities shown by these compounds in the in vivo and in vitro models have been established by using FVB transgenic mice model. These results suggest the suitability of the designed molecular framework as a potential scaffold for the design of molecules with inhibitory activity towards NF-kappaB and AP-1 mediated transcriptional activation, which may also exhibit anti-inflammatory and anti-cancer activity. This series of molecules warrants further study to explore their potential as therapies for use in chronic inflammatory conditions and cancer. Development of the synthetic protocol for the synthesis of this series of molecules, biological activities and a structure-activity relationship (SAR) have been discussed herein.

  12. Utility Battery Storage Systems Program plan: FY 1994--FY 1998

    Energy Technology Data Exchange (ETDEWEB)

    1994-02-01

    The Utility Battery Storage Systems Program, sponsored by the US Department of Energy (DOE), is addressing needed improvements so that the full benefits of these systems can be realized. A key element of the Program is the quantification of the benefits of batteries used in utility applications. The analyses of the applications and benefits are ongoing, but preliminary results indicate that the widespread introduction of battery storage by utilities could benefit the US economy by more than $26 billion by 2010 and create thousands of new jobs. Other critical elements of the DOE Program focus on improving the batteries, power electronics, and control subsystems and reducing their costs. These subsystems are then integrated and the systems undergo field evaluation. Finally, the most important element of the Program is the communication of the capabilities and benefits of battery systems to utility companies. Justifiably conservative, utilities must have proven, reliable equipment that is economical before they can adopt new technologies. While several utilities are leading the industry by demonstrating battery systems, a key task of the DOE program is to inform the entire industry of the value, characteristics, and availability of utility battery systems so that knowledgeable decisions can be made regarding future investments. This program plan for the DOE Utility Battery Storage Systems Program describes the technical and programmatic activities needed to bring about the widespread use of batteries by utilities. By following this plan, the DOE anticipates that many of the significant national benefits from battery storage will be achieved in the near future.

  13. ADVANCED UTILITY SIMULATION MODEL, REPORT OF SENSITIVITY TESTING, CALIBRATION, AND MODEL OUTPUT COMPARISONS (VERSION 3.0)

    Science.gov (United States)

    The report gives results of activities relating to the Advanced Utility Simulation Model (AUSM): sensitivity testing. comparison with a mature electric utility model, and calibration to historical emissions. The activities were aimed at demonstrating AUSM's validity over input va...

  14. Utility Solar Generation Valuation Methods

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Thomas N.; Dion, Phillip J.

    2009-06-30

    Tucson Electric Power (TEP) developed, tested and verified the results of a new and appropriate method for accurately evaluating the capacity credit of time variant solar generating sources and reviewed new methods to appropriately and fairly evaluate the value of solar generation to electric utilities. The project also reviewed general integrated approaches for adequately compensating owners of solar generation for their benefits to utilities. However, given the limited funding support and time duration of this project combined with the significant differences between utilities regarding rate structures, solar resource availability and coincidence of solar generation with peak load periods, it is well beyond the scope of this project to develop specific rate, rebate, and interconnection approaches to capture utility benefits for all possible utilities. The project developed computer software based evaluation method models to compare solar generation production data measured in very short term time increments called Sample Intervals over a typical utility Dispatch Cycle during an Evaluation Period against utility system load data. Ten second resolution generation production data from the SGSSS and actual one minute resolution TEP system load data for 2006 and 2007, along with data from the Pennington Street Garage 60 kW DC capacity solar unit installed in downtown Tucson will be applied to the model for testing and verification of the evaluation method. Data was provided by other utilities, but critical time periods of data were missing making results derived from that data inaccurate. The algorithms are based on previous analysis and review of specific 2005 and 2006 SGSSS production data. The model was built, tested and verified by in house TEP personnel. For this phase of the project, TEP communicated with, shared solar production data with and collaborated on the development of solar generation valuation tools with other utilities, including Arizona Public

  15. Heat utilization (2); Netsuriyo (2)

    Energy Technology Data Exchange (ETDEWEB)

    Akizawa, Jun [Tokyo University of Agriculture and Tecnology, Tokyo (Japan)

    1999-01-31

    (102) The application of the carbon dioxide separation and collection system using CPC to the thermal power plant. (103) The effect of the scattered light on collection of heat of solar pond. (104) The development of the Basin- multiple-effect compound type solar heat distiller. (Production and performance test of the small plant.) (105) On the plan of the new-model solar heat engine. (106) The performance prediction of solar power system using Stirling engine. (Part 2 The case in which the divided condenser was used.) (107) The trial manufacture of the sun cooker. It was announced and was made of 6 from various regions in this session on the heat utilization. On the multiple-effect compound type solar heat distiller, the comment that the feasibility could be expected from the simple structure was made. And, the question on system operation of allocation of the distillation quantity, etc. was actively made. On 2 of plan of the new-model solar heat engine and trial manufacture of the sun cooker, it was not possible that the publicator came for the aged to Okinawa, and instead, it became an announcement by tape and OHP blown in self. Though it was the form which there was no in the convention, it could be heard of that it is major field. It was thought, because there was some an announcement on the Stirling engine in the this session, place be able to. And, photograph and experimental result of the prototype are also included for the announcement of the sun cooker and want to desire the opportunities which hear the direct announcement. It wants to be thankful for hardship Mr.Naito the Science and Technology Agency National Aerospace Laboratory that it carried tape and OHP and assisted the announcement. The biomass. (108) The measurement approach of the environment resuscitation acceleration effect. (109) The basic research on the biogas storage by the clathration. The behavior of the carbon dioxide in the clathrate generation. (111) The solar thermal application

  16. Hydrogen utilization potential in subsurface sediments

    Directory of Open Access Journals (Sweden)

    Rishi Ram Adhikari

    2016-01-01

    Full Text Available Subsurface microbial communities undertake many terminal electron-accepting processes, often simultaneously. Using a tritium-based assay, we measured the potential hydrogen oxidation catalyzed by hydrogenase enzymes in several subsurface sedimentary environments (Lake Van, Barents Sea, Equatorial Pacific and Gulf of Mexico with different predominant electron-acceptors. Hydrogenases constitute a diverse family of enzymes expressed by microorganisms that utilize molecular hydrogen as a metabolic substrate, product or intermediate. The assay reveals the potential for utilizing molecular hydrogen and allows qualitative detection of microbial activity irrespective of the predominant electron-accepting process. Because the method only requires samples frozen immediately after recovery, the assay can be used for identifying microbial activity in subsurface ecosystems without the need to preserve live material.We measured potential hydrogen oxidation rates in all samples from multiple depths at several sites that collectively span a wide range of environmental conditions and biogeochemical zones. Potential activity normalized to total cell abundance ranges over five orders of magnitude and varies, dependent upon the predominant terminal electron acceptor. Lowest per-cell potential rates characterize the zone of nitrate reduction and highest per-cell potential rates occur in the methanogenic zone. Possible reasons for this relationship to predominant electron acceptor include (i increasing importance of fermentation in successively deeper biogeochemical zones and (ii adaptation of H2ases to successively higher concentrations of H2 in successively deeper zones.

  17. Back to Bentham? Explorations of experience utility

    NARCIS (Netherlands)

    Wakker, P.P.; Kahneman, D.; Sarin, R.K.

    1997-01-01

    Two core meanings of "utility" are distinguished. "Decision utility" is the weight of an outcome in a decision. "Experienced utility" is hedonic quality, as in Bentham's usage. Experienced utility can be reported in real time (instant utility), or in retrospective evaluations of past episodes

  18. Back to Bentham? Explorations of experience utility

    NARCIS (Netherlands)

    Wakker, P.P.; Kahneman, D.; Sarin, R.K.

    1997-01-01

    Two core meanings of "utility" are distinguished. "Decision utility" is the weight of an outcome in a decision. "Experienced utility" is hedonic quality, as in Bentham's usage. Experienced utility can be reported in real time (instant utility), or in retrospective evaluations of past episodes (remem

  19. Effective Utilization Of Tax Revenue In Nigeria

    Directory of Open Access Journals (Sweden)

    Michael Baghebo

    2012-07-01

    Full Text Available This paper is an attempt to examine the effective utilization of tax revenue vis-à-vis the impact of Government expenditure on economic growth and development of Nigeria. Government intervenes in the economy through a variety of policies, of these policies, two are most important. They are fiscal and monetary policy. This work is on the expenditure component of fiscal policy. Until recently, Nigeria has been one of the most disappointing development stories of the modern era-a cautionary tale of the risk of huge revenue from taxation in an environment of weak governance. In recent years, the most conspicuous fact about Nigeria’s economy is that corruption and mismanagement of its post- colonial government has prevented the channeling of the country’s resources from taxation and other sources into lasting improvements in infrastructure and the construction of a sound base for self sustaining economic development. Thus despite increasing revenue base, the rate of poverty, unemployment, high rate of inflation, low capacity utilization in industry, debt overhang, deterioration or stagnation of economic activities still prevail. From the foregoing, it should be clear what need to be done to improve the effective utilization of government fiscal (spending operations by: improving the quantity and quality of resources available to the government for its activities and improve the ways in which the resources available to the government are managed through the application of cost benefit analysis, expenditure analysis, transparency and accountability in the conduct of government business and also ensuring at all times that people of doubtful character are not elected into government or are not entrusted with the management of public resources. Avoiding actions that induce government officials to behave in corrupt ways and been genuinely interested in what government is doing. That is been critical in the activities of government.

  20. Utilization and utility of clinical laboratory reports with graphical elements

    Directory of Open Access Journals (Sweden)

    Brian H Shirts

    2012-01-01

    Full Text Available Background: Graphical reports that contain charts, images, and tables have potential to convey information more effectively than text-based reports; however, studies have not measured how much clinicians value such features. We sought to identify factors that might influence the utilization of reports with graphical elements postulating that this is a surrogate for relative clinical utility of these graphical elements. Materials and Methods: We implemented a pilot project at ARUP laboratories to develop online enhanced laboratory test reports that contained graphical elements. We monitored on-demand clinician access to reports generated for 48 reportable tests over 22 months. We evaluated utilization of reports with graphical elements by clinicians at all institutions that use ARUP as a reference laboratory using descriptive statistics, regression, and meta-analysis tools to evaluate groups of similar test reports. Results: Median download rate by test was 8.6% with high heterogeneity in download rates between tests. Test reports with additional graphical elements were not necessarily downloaded more often than reports without these elements. Recently implemented tests and tests reporting abnormal results were associated with higher download rates (P < 0.01. Higher volume tests were associated with lower download rates (P = 0.03. Conclusions: In select cases graphical information may be clinically useful, particularly for less frequently ordered tests and in on reports of abnormal results. The utilization data presented could be used as a reference point for other laboratories planning on implementing graphical reporting. However, between-test heterogeneity was high and in many cases graphical elements may add little clinical utility, particularly if these merely reinforce information already contained in text based reports.

  1. E-Commerce for utilities

    Energy Technology Data Exchange (ETDEWEB)

    Malicky, M. [Metzler and Associates, Deerfield, IL (United States)

    1999-07-01

    The use of E-Commerce by energy utility and service companies was discussed. E-Commerce was described as being all communication via the web including Internet, Intranet and Extranet. E-Commerce communication includes the exchange of information, data, money services, products, ideas, conversations, knowledge, inventory and events. E-Commerce can be applied to electric and gas utilities to enhance energy marketing, delivery, retail energy, energy services, retail services and customer satisfaction. This means of communication is quickly becoming an essential part of customer care strategy. It reduces costs and improves performance. It was forecasted that E-Commerce will more than double from 1998 to 2001. 15 refs.

  2. Utility launches computer information service

    Energy Technology Data Exchange (ETDEWEB)

    Beaty, W. [ed.; Ordonez, B.

    1994-12-01

    Three employees at Lee County Electric Cooperative in North Fort Meyers, Fla., have developed InterLine, an on-line computer service designed specifically for the electric utility industry. Since introducing InterLine to the public, the development team has been looking at what areas of information would be most useful to subscribers. In the initial phase, system features include forums on electrical engineering, safety and health and transmission and distribution, a library of files and the Internet gateway. If InterLIne is embraced by the electric utility industry, long range plans are to take it internationls.

  3. Utilities and energy efficiency Denmark report

    Energy Technology Data Exchange (ETDEWEB)

    Olesen, G.B.; Lyck, N.C.

    1996-11-01

    The report is the Danish contribution to the project `Utilities and Energy Efficiency` produced for the European Commission by IET, Nikkel straat 15, 4823 AE Breda, The Netherlands. Information is given under the headings of existing situation and desired situation. Recommendations are also given under the headings of legislation concerning the objectives of the utilities, of government programs and targets, of organizational structure, required market dependence and internal objectives of the utilities, for regulation and standardization, and of tariff structure. Flow diagrams are presented for the Danish energy system 1990, 1993. The 1993 follow up of the energy plan `Energy 2000` points out that the goals set up at that time, first and foremost the 20% reduction in CO{sub 2} emissions in 2005 compared to the 1988 level, will not be reached without changes in policy, such as an increase in the use of renewable energy, more transparent and consistent tariff systems as a greater incentive for energy conservation, regulations on thermal insulation of houses, increase in public information activities,a new subsidy scheme to stimulate improvements of energy efficiency in buildings and regulations on energy supply to large buildings. (ARW) 55 refs.

  4. Comparative studies of utilization of industrial electron accelerators and adsorption with activated carbon for industrial effluent treatment; Estudo comparativo da utilizacao de aceleradores industriais de eletrons e adsorcao com carvao ativado para tratamento de efluentes industriais

    Energy Technology Data Exchange (ETDEWEB)

    Sampa, Maria Helena de O.; Rela, Paulo R.; Duarte, Celina Lopes; Las Casas, Alexandre; Mori, Manoel Nunes; Omi, Nelson M. [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)]. E-mail: mhosampa@ipen.br

    2005-07-01

    A technical and economical feasibility study was performed comparing the use electron beam and activated charcoal for treatment of industrial wastewater. In this study was used synthetic solutions, prepared in laboratory with organic compounds standards, where the composition was focused on the critical organic contaminants usually presented in wastewater from petrochemical industry. For the sample irradiation was used an industrial electron beam from Radiation Dynamics Inc. 1.5 MeV - 37.5 kW setup in IPEN. The doses ranged from 5 kGy to 100 kGy. A common granulated activated charcoal in a fixed-bed absorber glass column was used to study the pollutants absorption performance. The results show that if the adequate irradiation dose was delivered to the organic pollutant, it is possible to conclude for the studied compounds that the Electron Beam Process is, in aspect of organic removal efficiency, similar to the activated carbon process. (author)

  5. Clinical utility of measures of breathlessness.

    Science.gov (United States)

    Cullen, Deborah L; Rodak, Bernadette

    2002-09-01

    The clinical utility of measures of dyspnea has been debated in the health care community. Although breathlessness can be evaluated with various instruments, the most effective dyspnea measurement tool for patients with chronic lung disease or for measuring treatment effectiveness remains uncertain. Understanding the evidence for the validity and reliability of these instruments may provide a basis for appropriate clinical application. Evaluate instruments designed to measure breathlessness, either as single-symptom or multidimensional instruments, based on psychometrics foundations such as validity, reliability, and discriminative and evaluative properties. Classification of each dyspnea measurement instrument will recommend clinical application in terms of exercise, benchmarking patients, activities of daily living, patient outcomes, clinical trials, and responsiveness to treatment. Eleven dyspnea measurement instruments were selected. Each instrument was assessed as discriminative or evaluative and then analyzed as to its psychometric properties and purpose of design. Descriptive data from all studies were described according to their primary patient application (ie, chronic obstructive pulmonary disease, asthma, or other patient populations). The Borg Scale and the Visual Analogue Scale are applicable to exertion and thus can be applied to any cardiopulmonary patient to determine dyspnea. All other measures were determined appropriate for chronic obstructive pulmonary disease, whereas the Shortness of Breath Questionnaire can be applied to cystic fibrosis and lung transplant patients. The most appropriate utility for all instruments was measuring the effects on activities of daily living and for benchmarking patient progress. Instruments that quantify function and health-related quality of life have great utility for documenting outcomes but may be limited as to documenting treatment responsiveness in terms of clinically important changes. The dyspnea

  6. Present status of underground thermal utilization in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Yasukawa, Kasumi [Geological Survey of Japan, Tsukuba (Japan); Takasugi, Shinji [GeoSystem Co Ltd., Tokyo (Japan)

    2003-12-01

    Utilization of low-enthalpy geothermal energy in Japan, especially with the application of geothermal heat pumps, is far behind other industrial countries. In 1998, a feasibility study was made of utilizing Japan's low-enthalpy geothermal resources. Since 2001 the Geo-Heat Promotion Association of Japan (GeoHPJ) began its activities with the objective of installing 140,000 heat pump systems in private houses by the target year of 2010. The Geothermal Research Society of Japan has also launched new activities in this sector. Research groups in universities and other national institutes have started geoscientific research on the utilization of low-enthalpy resources and private, academic and governmental sectors have consequently begun promoting geothermal heat pump utilization. (author)

  7. Utility Energy Services Contracts: Enabling Documents

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-05-01

    Utility Energy Services Contracts: Enabling Documents provides materials that clarify the authority for Federal agencies to enter into utility energy services contracts (UESCs), as well as sample documents and resources to ease utility partnership contracting.

  8. Expected utility with lower probabilities

    DEFF Research Database (Denmark)

    Hendon, Ebbe; Jacobsen, Hans Jørgen; Sloth, Birgitte

    1994-01-01

    An uncertain and not just risky situation may be modeled using so-called belief functions assigning lower probabilities to subsets of outcomes. In this article we extend the von Neumann-Morgenstern expected utility theory from probability measures to belief functions. We use this theory...

  9. Production and utilization of radioisotopes

    Energy Technology Data Exchange (ETDEWEB)

    Sekine, Toshiaki [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Matsuoka, Hiromitsu

    1999-03-01

    A plan of developing radioisotopes with a high power proton accelerator of the Neutron Science Project is presented. The status of production and utilization of radioisotopes in Japan is briefly discussed. The radioisotopes to be produced for biomedical use are discussed together with the facility for production of those radioisotopes and for research with the products. (author)

  10. 1999 international ash utilization symposium

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    112 papers were presented covering various aspects of the utilization of coal and other combustion products. Topics included fundamental chemistry and mineralogy, new products, health and environmental aspects, economic development issues, agricultural and mine reclamation applications, concrete and cement, and fly ash beneficiation technologies. Selected papers will be published in the journal 'Fuel'.

  11. Administrative Utility Analysis: Study Summary.

    Science.gov (United States)

    Peat, Marwick, Mitchell and Co., San Juan, Puerto Rico.

    This document summarizes the recommendations made as a result of a study on administrative utility analysis and vocational education programs for Puerto Rico. The major recommendation was that the Area of Vocational and Technical Education (AVTE) in the Puerto Rico Department of Education be restructured at the central organizational level, for…

  12. Wind energy utilization: A bibliography

    Science.gov (United States)

    1975-01-01

    Bibliography cites documents published to and including 1974 with abstracts and references, and is indexed by topic, author, organization, title, and keywords. Topics include: Wind Energy Potential and Economic Feasibility, Utilization, Wind Power Plants and Generators, Wind Machines, Wind Data and Properties, Energy Storage, and related topics.

  13. Zymomonas with improved xylose utilization

    Science.gov (United States)

    Viitanen, Paul V [West Chester, PA; Tao, Luan [Havertown, PA; Zhang, Yuying [New Hope, PA; Caimi, Perry G [Kennett Square, PA; McCutchen, Carol M [Wilmington, DE; McCole, Laura [East Fallowfield, PA; Zhang, Min [Lakewood, CO; Chou, Yat-Chen [Lakewood, CO; Franden, Mary Ann [Centennial, CO

    2011-08-16

    Strains of Zymomonas were engineered by introducing a chimeric xylose isomerase gene that contains a mutant promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene. The promoter directs increased expression of xylose isomerase, and when the strain is in addition engineered for expression of xylulokinase, transaldolase and transketolase, improved utilization of xylose is obtained.

  14. Utility of spoken dialog systems

    CSIR Research Space (South Africa)

    Barnard, E

    2008-12-01

    Full Text Available the evolution of poken dialog system research in the developed world, and show that the utility of speech is based on user factors and application factors (among others). After adjusting the factors for the developing world context, and plotting...

  15. Utilization and management of alder.

    Science.gov (United States)

    David G. Briggs; Dean S. DeBell; William A. Atkinson

    1978-01-01

    In the Pacific Northwest and British Columbia, red alder often grows on forest lands following natural or man-caused disturbances. Frequently ignored as a pest or weed, many alder stands have developed to the point where important utilization and management questions are being asked. It is recognized that alder is a fast growing species, and that its rapid early growth...

  16. The Library Space Utilization Methodology.

    Science.gov (United States)

    Hall, Richard B.

    1978-01-01

    Describes the Library Space Utilization (LSU) methodology, which demonstrates that significant information about the functional requirements of a library can be measured and displayed in a quantitative and graphic form. It measures "spatial" relationships between selected functional divisions; it also determines how many people--staff and…

  17. Active ingredients of olive oil processing wastes and their comprehensive utilization technique:a review%橄榄油加工废弃物中的活性成分及其综合利用技术研究进展

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    在橄榄油的生产加工过程中产生了大量的富含生物活性物质的废弃物,这些废弃物均未得到有效的开发利用,造成了极大的资源浪费和环境污染.实现橄榄油加工废弃物的高值化综合开发利用是实现油橄榄产业可持续发展的重要保障之一.结合国内外研究报道,总结了橄榄油加工废弃物中的活性成分及其综合利用技术的研究现状,旨在为橄榄油加工废弃物的综合开发利用提供可行思路和技术参考.%Abundant wastes with bioactive compounds are produced during olive oil production. Those wastes are not utilized reasonably and lead to the problems of resource waste and environmental pollution. Comprehensive exploitation and utilization of olive oil processing wastes ( OPW) with high value is one of the most important strategies for olive industry achieving sustainable development. The active ingredients in OPW and their comprehensive utilization techniques were summarized so as to provide a feasible solu-tion and technical reference for OPW.

  18. Nuclear fuel activity with minor actinides after their useful life in a BWR; Actividad del combustible nuclear con actinidos menores despues de su vida util en un reactor BWR

    Energy Technology Data Exchange (ETDEWEB)

    Martinez C, E.; Ramirez S, J. R.; Alonso V, G., E-mail: eduardo.martinez@inin.gob.mx [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2016-09-15

    Nuclear fuel used in nuclear power reactors has a life cycle, in which it provides energy, at the end of this cycle is withdrawn from the reactor core. This used fuel is known as spent nuclear fuel, a strong problem with this fuel is that when the fuel was irradiated in a nuclear reactor it leaves with an activity of approximately 1.229 x 10{sup 15} Bq. The aim of the transmutation of actinides from spent nuclear fuel is to reduce the activity of high level waste that must be stored in geological repositories and the lifetime of high level waste; these two achievements would reduce the number of necessary repositories, as well as the duration of storage. The present work is aimed at evaluating the activity of a nuclear fuel in which radioactive actinides could be recycled to remove most of the radioactive material, first establishing a reference of actinides production in the standard nuclear fuel of uranium at end of its burning in a BWR, and a fuel rod design containing 6% of actinides in an uranium matrix from the enrichment tails is proposed, then 4 standard uranium fuel rods are replaced by 4 actinide bars to evaluate the production and transmutation of the same, finally the reduction of actinide activity in the fuel is evaluated. (Author)

  19. Comparison of fructooligosaccharide utilization by Lactobacillus and Bacteroides species.

    Science.gov (United States)

    Endo, Hiroya; Tamura, Kazuji; Fukasawa, Tomoyuki; Kanegae, Minoru; Koga, Jinichiro

    2012-01-01

    The utilization of 1-kestose (GF(2)) and nystose (GF(3)), the main components of fructooligosaccharides (FOS), by Lactobacillus and Bacteroides species was examined. Of seven Lactobacillus and five Bacteroides strains that utilized FOS, L. salivarius, L. rhamnosus, L. casei, and L. gasseri utilized only GF(2), whereas L. acidophilus and all the Bacteroides strains utilized both GF(2) and GF(3). Only the strains able to utilize both GF(2) and GF(3) had β-fructosidase activity in the culture supernatants. The culture supernatants of the Lactobacillus strains had higher β-fructosidase activity for GF(2) than for GF(3), whereas those of the Bacteroides strains had higher activity for GF(3) than for GF(2). Furthermore, β-fructosidase activity of the culture supernatants of the Lactobacillus cells grown in the GF(3) medium was much higher than that of the cells grown in the GF(2) medium, whereas the activity of the culture supernatants of the Bacteroides cells grown in the GF(3) medium was almost the same as that of the cells grown in the GF(2) medium. These results indicate that Lactobacillus species metabolize FOS in a different way from that of Bacteroides species.

  20. Effects of Phosphorus Supply Level on Phosphatase Activity and Phosphorus Absorption and Utilization Efficiency of Young Newhall Navel Orange Trees%供磷水平对纽荷尔脐橙幼树磷酸酶活性和磷素吸收利用效率的影响

    Institute of Scientific and Technical Information of China (English)

    樊卫国; 王立新

    2013-01-01

    The experiment of young Newhall navel orange trees grafted on Poncirus trifoliate (L. ) Raf. in pots were conducted to study the effects of various phosphorus supply levels on the acid phosphatase (APase) activity and phosphorus absorption and utilization efficiency and to provide the scientific basis for soil nutrition diagnosis and determination of suitable phosphorus application quantity in Newhall navel orange garden. The results showed that the APase activity of roots, leaves and soil and SAPase activity of roots were negatively correlated to phosphorus supply levels among 7 phosphorus supply treatments range from 5 to 125 mg/kg. The APase activity of roots, leaves and soil and SAPase activity of roots were the highest and phosphorus utilization efficiency of the whole plant, above-ground part and roots was the maximum under 5 mg/kg phosphorus supply level but leaves displayed the symptoms of phosphorus deficiency. The biomass and phosphorus absorption efficiency of the whole plant, above-ground part and roots under 25 mg/kg phosphorus supply level reached the highest but its phosphorus utilization efficiency was lower than that under 5 mg/kg phosphorus supply level. The growth of young Newhall navel orange trees under above 65 mg/kg phosphorus supply level was inhibited obviously and the APase activity of roots, leaves and soil and SAPase activity of roots, as well as phosphorus absorption and utilization efficiency were reduced significantly. In conclusion,25 -45 mg/kg phosphorus supply level is beneficial to growth and phosphorus absorption and utilization of young Newhall navel orange trees.%为了探索柑橘对磷养分的吸收利用特性,为柑橘园土壤养分的诊断及施磷量的确定提供科学依据,以枳砧纽荷尔脐橙幼树为材料,采用盆栽试验研究了不同供磷水平对其磷酸酶活性和磷素吸收利用效率的影响.结果表明:在5~125 mg/kg 7个供磷水平处理中,纽荷尔脐橙幼树根系、叶片及土壤

  1. Subjective ambiguity, expected utility and Choquet expected utility

    OpenAIRE

    Jiankang Zhang

    2002-01-01

    Using the Savage set up, this paper provides a simple axiomatization of the Choquet Expected Utility model where the capacity is an inner measure. Two attractive features of the model are its specificity and the transparency of its axioms. The key axiom states that the decision-maker uses unambiguous acts to approximate ambiguous ones. In addition, the notion of `ambiguity' is subjective and derived from preferences.

  2. Presence and the utility of audio spatialization

    DEFF Research Database (Denmark)

    Bormann, Karsten

    2005-01-01

    performance by varying the spatial fidelity of the audio independently of its relevance to performance on the search task that subjects were to perform. This was achieved by having conditions in which subjects searched for a music-playing radio (an active sound source) and having conditions in which......The primary concern of this paper is whether the utility of audio spatialization, as opposed to the fidelity of audio spatialization, impacts presence. An experiment is reported that investigates the presence-performance relationship by decoupling spatial audio fidelity (realism) from task...... the playing radio would be stationary (a passive sound source) while subjects searched for some other object. Independent of this, the music emitted by the radio would be either fully spatialized or directional but nonattenuated. Findings include that for subjects searching for the active sound source, being...

  3. Workplace Stress, Organizational Factors and EAP Utilization

    Science.gov (United States)

    Azzone, Vanessa; McCann, Bernard; Merrick, Elizabeth Levy; Hiatt, Deirdre; Hodgkin, Dominic; Horgan, Constance

    2013-01-01

    This study examined relationships between workplace stress, organizational factors and use of EAP counseling services delivered by network providers in a large, privately-insured population. Claims data were linked to measures of workplace stress, focus on wellness/prevention, EAP promotion, and EAP activities for health care plan enrollees from 26 employers. The association of external environment and work organization variables with use of EAP counseling services was examined. Higher levels of EAP promotion and worksite activities were associated with greater likelihood of service use. Greater focus on wellness/prevention and unusual and significant stress were associated with lower likelihood of service use. Results provide stakeholders with insights on approaches to increasing utilization of EAP services. PMID:24058322

  4. A Functional Magnetic Resonance Imaging Study to Investigate the Utility of a Picture Imagination Task in Investigating Neural Responses in Patients with Chronic Musculoskeletal Pain to Daily Physical Activity Photographs.

    Directory of Open Access Journals (Sweden)

    Ann M Taylor

    Full Text Available Pain-related anxiety and fear are associated with increased difficulties in attention, increased awareness of pain, impaired disengagement from pain, and can moderate the effects of attentional coping attempts. Accurately assessing the direct impact of pain-related anxiety and fear on pain behavior has proved difficult. Studies have demonstrated no or limited influence of pain-related fear and anxiety on behavior but this may be due to inherent problems with the scales used. Neuroimaging has improved the understanding of neural processes underlying the factors that influence pain perception. This study aimed to establish if a Picture and Imagination Task (PIT, largely developed from the Photographs of Daily Activity (PHODA assessment tool, could help explore how people living with chronic pain process information about daily activities. Blood oxygenation level dependent (BOLD functional magnetic resonance imaging (fMRI was used to compare brain responses in patients with chronic musculoskeletal pain (CMSKP (n = 15 and healthy controls (n = 15. Subjects were asked to imagine how they would feel mentally and physically if asked to perform daily activities illustrated in PIT. The results found that a number of regions involved in pain processing saw increased BOLD activation in patients compared with controls when undertaking the task and included the insula, anterior cingulate cortex, thalamus and inferior and superior parietal cortices. Similarly, increased BOLD responses in patients compared to controls in the frontal pole, paracingulate and the supplementary motor cortex may be suggestive of a memory component to the responses The amygdala, orbitofrontal cortex, substantia nigra/ventral tegmentum, putamen, thalamus, pallidum, inferior parietal (supramarginal and angular gyrus and cingulate cortex were also seen to have greater differences in BOLD signal changes in patients compared with controls and many of these regions are also associated

  5. PEMANFAATAN PIROPILIT SEBELUM DAN SESUDAH AKTIVASI SEBAGAI ADSORBEN PADA PROSES PENURUNAN BILANGAN PEROKSIDA DAN KADAR ASAM LEMAK BEBAS MINYAK JELANTAH (The Utilization of Pyrophilite Before and After Activation as an Adsorbent on Decreased Level Process

    Directory of Open Access Journals (Sweden)

    Sari Dewi Cahyaning Tyas

    2011-11-01

    Full Text Available ABSTRAK Telah dilakukan penelitian dengan tujuan: 1. Mengetahui perubahan karakteristik piropilit meliputi intensitas serapan gugus aktif OH- dan luas permukaan. 2. Mengetahui ada tidaknya pengaruh variasi jenis dan masa adsorben terhadap penurunan kadar asam lemak bebas dan bilangan peroksida minyak jelantah. Penelitian ini terdiri atas dua tahap: 1. Pembuatan adsorben yakni piropilit sebelum dan sesudah aktivasi. 2. Adsorpsi asam lemak bebas dan senyawa peroksida minyak jelantah. Analisis hasil penelitian tahap 1 dilakukan dengan Spektrofotometer IR dan ”Surface area analyzer”, tahap 2 dengan metode statistik analisis varian dua arah. Hasil penelitian tahap 1 menunjukkan ada perubahan karakteristik piropilit yakni peningkatan intensitas serapan gugus aktif OH- dan luas permukaan sebelum dan sesudah aktivasi berturut-turut 10-20 % menjadi 20-30 % dan 8,374 m2/g menjadi 11,790 m2/g. Untuk penelitian tahap 2 menunjukkan tidak ada interaksi antara jenis dan masa adsorben sedangkan dari masing-masing variabel ternyata ada pengaruh yang signifikan. Hal ini ditunjukkan bahwa pada masa adsorben 5 gram, sebelum dan sesudah aktivasi asam lemak bebas mengalami penurunan dari 0,6693 % menjadi 0,4131 % dan 0,3731 % sedangkan bilangan peroksida dari 1,1889 meq/Kg menjadi 0,4973 meq/Kg dan 0,4632 meq/Kg. ABSTRACT Has been studied with the aim of: 1. Knowing the characteristic changes in absorption intensity piropilit include active OH-groups and surface area. 2. Determine whether there is the influence of adsorbent type and period of decreased levels of free fatty acid and peroxide numbers used cooking oil.Study consisted of two stages: 1. Making the piropilit adsorbent before and after activation. 2. Adsorption of free fatty acid and peroxide compound used cooking oil. Analysis of the results of the study phase 1 performed with IR spectrophotometer and "Surface area analyzer", phase 2 with statistical methods of two-way analysis of variance.The results

  6. Reactive dye extraction utilizing regenerated bleaching earth

    Directory of Open Access Journals (Sweden)

    M. Shahi

    2017-09-01

    Full Text Available Bentonite bleaching earth is utilized for purifying used motor oil through a recovery process in order to improve the quality and stability of the final product. Indeed, spent bleaching earth is generated due to adsorbing oil impurities. Polluted spent bleaching earth contains 20-40% (w/w oil and is flammable. Its disposal without pre-treatment leads to loss of oil along with environmental impacts. Accordingly, similar studies have been conducted since 1979 until now. This research was a laboratory study on reactive dye adsorption. Cleaning bleaching clay, thermal remediation and acid washing activation methods were utilized. Response surface methodology was used to design the experiments and determine the optimal parameters in order to run the dye adsorption process. The main experimental parameters have been concluded as temperature (200-800 °C, acid solution concentration (0.1-3 M, dye solution concentration (1-35 ppm, and ratio of activated earth to dye solution (0.1-2 %, w/w. Results revealed that dye adsorption process along with oil removal at a temperature of 650 °C, acid solution concentration of 0.83 M, dye solution concentration of 11.75 ppm and ratio of activated earth to dye solution of 1.52 % (w/w results in an adsorption efficiency of 68.57%. This removal efficiency is a bit higher than activated virgin bleaching earth and much higher than virgin bleaching earth, which has adsorption capacities of 66.75% and 51.56%, respectively. Considering this recycling process, the purified material is quite acceptable technically, environmentally and economically.

  7. Possibilities of utilizing power plant fly ashes

    Directory of Open Access Journals (Sweden)

    Mezencevová Andrea

    2003-09-01

    Full Text Available The burning of fossil fuels in industrial power stations plays a significant role in the production of thermal and electrical energy. Modern thermal power plants are producing large amounts of solid waste, mainly fly ashes. The disposal of power plant waste is a large environmental problem at the present time. In this paper, possibilities of utilization of power plant fly ashes in industry, especially in civil engineering, are presented. The fly ash is a heterogeneous material with various physical, chemical and mineralogical properties, depending on the mineralogical composition of burned coal and on the used combustion technology. The utilization of fly ashes is determined of their properties. The fineness, specific surface area, particle shape, density, hardness, freeze-thaw resistance, etc. are decisive. The building trade is a branch of industry, which employs fly ash in large quantities for several decades.The best utilization of fluid fly ashes is mainly in the production of cement and concrete, due to the excellent pozzolanic and cementitious properties of this waste. In the concrete processing, the fly ash is utilized as a replacement of the fine aggregate (fine filler or a partial replacement for cement (active admixture. In addition to economic and ecological benefits, the use of fly ash in concrete improves its workability and durability, increases compressive and flexural strength, reduces segregation, bleeding, shrinkage, heat evolution and permeability and enhances sulfate resistance of concrete.The aim of current research is to search for new technologies for the fly ash utilization. The very interesting are biotechnological methods to recovery useful components of fly ashes and unconventional methods of modification of fly ash properties such as hydrothermal zeolitization and mechanochemical modification of its properties. Mechanochemistry deals with physico - chemical transformations and chemical reactions of solids induced by

  8. Fluid Substitution Modeling to Determine Sensitivity of 3D Vertical Seismic Profile Data to Injected CO­2­ at an active Carbon Capture, Utilization and Storage Project, Farnsworth field, TX.

    Science.gov (United States)

    Haar, K. K.; Balch, R. S.

    2015-12-01

    The Southwest Regional Partnership on Carbon Sequestration monitors a CO2 capture, utilization and storage project at Farnsworth field, TX. The reservoir interval is a Morrowan age fluvial sand deposited in an incised valley. The sands are between 10 to 25m thick and located about 2800m below the surface. Primary oil recovery began in 1958 and by the late 1960's secondary recovery through waterflooding was underway. In 2009, Chaparral Energy began tertiary recovery using 100% anthropogenic CO2 sourced from an ethanol and a fertilizer plant. This constitutes carbon sequestration and fulfills the DOE's initiative to determine the best approach to permanent carbon storage. One purpose of the study is to understand CO­2 migration from injection wells. CO2­ plume spatial distribution for this project is analyzed with the use of time-lapse 3D vertical seismic profiles centered on CO2 injection wells. They monitor raypaths traveling in a single direction compared to surface seismic surveys with raypaths traveling in both directions. 3D VSP surveys can image up to 1.5km away from the well of interest, exceeding regulatory requirements for maximum plume extent by a factor of two. To optimize the timing of repeat VSP acquisition, the sensitivity of the 3D VSP surveys to CO2 injection was analyzed to determine at what injection volumes a seismic response to the injected CO­2 will be observable. Static geologic models were generated for pre-CO2 and post-CO2 reservoir states through construction of fine scale seismic based geologic models, which were then history matched via flow simulations. These generated static states of the model, where CO2­ replaces oil and brine in pore spaces, allow for generation of impedance volumes which when convolved with a representative wavelet generate synthetic seismic volumes used in the sensitivity analysis. Funding for the project is provided by DOE's National Energy Technology Laboratory (NETL) under Award No. DE-FC26-05NT42591.

  9. RTNS-II utilization plan

    Energy Technology Data Exchange (ETDEWEB)

    Zwilsky, Klaus M.

    1978-09-01

    This plan describes a general program for the effective utilization of this resource by the fusion materials community. Because its flux is low relative to levels expected in commercial fusion reactors, the RINS-II is not expected to produce data of direct engineering significance (with some exceptions). Rather, it will be used chiefly to aid in the development of models of high energy neutron effects. Such models are needed in projecting engineering data obtained in high flux fission reactors to the fusion environment. Fission reactors, because of their relatively soft neutron spectra, cannot produce the high ratio of transmutations to displacements (except in an important special case) or the high energy recoil atoms appropriate to fusion reactors utilizing the D-T reaction.

  10. Introduction to drug utilization research

    DEFF Research Database (Denmark)

    Wettermark, Björn; Elseviers, Monique; Almarsdóttir, Anna Birna

    2016-01-01

    Qualitative research methods derive from the social sciences. Their use in drug utilization research is increasingly widespread, especially in understanding patient and prescriber perspectives. The main focus in qualitative research is exploration of a given phenomenon in order to get a wider und...... understanding of why and how it appears. Qualitative research methods build on various theoretical underpinnings/schools of thought. The same validity and quality criteria cannot be used for both qualitative and quantitative methods.......Qualitative research methods derive from the social sciences. Their use in drug utilization research is increasingly widespread, especially in understanding patient and prescriber perspectives. The main focus in qualitative research is exploration of a given phenomenon in order to get a wider...

  11. Utilization of the terrestrial cyanobacteria

    Science.gov (United States)

    Katoh, Hiroshi; Tomita-Yokotani, Kaori; Furukawa, Jun; Kimura, Shunta; Yokoshima, Mika; Yamaguchi, Yuji; Takenaka, Hiroyuki

    The terrestrial, N _{2}-fixing cyanobacterium, Nostoc commune has expected to utilize for agriculture, food and terraforming cause of its extracellular polysaccharide, desiccation tolerance and nitrogen fixation. Previously, the first author indicated that desiccation related genes were analyzed and the suggested that the genes were related to nitrogen fixation and metabolisms. In this report, we suggest possibility of agriculture, using the cyanobacterium. Further, we also found radioactive compounds accumulated N. commune (cyanobacterium) in Fukushima, Japan after nuclear accident. Thus, it is investigated to decontaminate radioactive compounds from the surface soil by the cyanobacterium and showed to accumulate radioactive compounds using the cyanobacterium. We will discuss utilization of terrestrial cyanobacteria under closed environment. Keyword: Desiccation, terrestrial cyanobacteria, bioremediation, agriculture

  12. Tactical Utility of Tailored Systems

    Science.gov (United States)

    2015-07-10

    www.popsci.com/ cars /article/2011-06/how-first- crowdsourced-military- car -can-remake-future-defense- manufacturing Tactical Utility of Tailored Systems...year lead time to develop a piece of equipment, if we were able to collapse the pace of which that manufacturing takes place, that would save taxpayers...within budget. This paper hopes to explore the idea of combining virtual environments and rapid manufacturing to create tailored materiel specific

  13. Purdue Solar Energy Utilization Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Agrawal, Rakesh [Purdue

    2014-01-21

    The objective of this project is to establish and set-up a laboratory that will facilitate research and development of new low-cost and high-efficiency solar energy utilization technologies at Purdue University. The outcome will help spur the creation of solar energy start-up companies and eventually a solar energy industry in Indiana that can help fulfill the growing national demand for solar energy.

  14. Microorganism Utilization for Synthetic Milk

    Science.gov (United States)

    Morford, Megan A.; Khodadad, Christina L.; Caro, Janicce I.; Spencer, LaShelle E.; Richards, Jeffery T.; Strayer, Richard F.; Birmele, Michele N.; Wheeler, Raymond M.

    2014-01-01

    A desired architecture for long duration spaceflight, like aboard the International Space Station or for future missions to Mars, is to provide a supply of fresh food crops for the astronauts. However, some crops can create a high proportion of inedible plant waste. The main goal of the Synthetic Biology project, Cow in a Column, was to produce the components of milk (sugar, lipid, protein) from inedible plant waste by utilizing microorganisms (fungi, yeast, bacteria). Of particular interest was utilizing the valuable polysaccharide, cellulose, found in plant waste, to naturally fuel-through microorganism cellular metabolism- the creation of sugar (glucose), lipid (milk fat), and protein (casein) in order to produce a synthetic edible food product. Environmental conditions such as pH, temperature, carbon source, aeration, and choice microorganisms were optimized in the laboratory and the desired end-products, sugars and lipids, were analyzed. Trichoderma reesei, a known cellulolytic fungus, was utilized to drive the production of glucose, with the intent that the produced glucose would serve as the carbon source for milk fat production and be a substitute for the milk sugar lactose. Lipid production would be carried out by Rhodosporidium toruloides, yeast known to accumulate those lipids that are typically found in milk fat. Results showed that glucose and total lipid content were below what was expected during this phase of experimentation. In addition, individual analysis of six fatty acids revealed that the percentage of each fatty acid was lower than naturally produced bovine milk. Overall, this research indicates that microorganisms could be utilized to breakdown inedible solid waste to produce useable products. For future work, the production of the casein protein for milk would require the development of a genetically modified organism, which was beyond the scope of the original project. Additional trials would be needed to further refine the required

  15. Electroluminescence of a Multi-Layered Organic Light-Emitting Diode Utilizing Trans-4-[p-[N-methyl-N-(hydroxymethyl)amino]styryl]-N-Methylphridinium Tetraphenylborate as the Active Layer

    Science.gov (United States)

    Feng, Xue-Yuan; Zhang, Jia-Yu; Xu, Chun-Xiang; Qiao, Yi; Cui, Yi-Ping

    2006-06-01

    Employing an organic dye salt of trans-4-[p-[N-methyl-N-(hydroxymethyl)amino]styryl]-N-methylphridinium tetraphenylborate (ASPT) as the active layer, 8-hydrocyquinoline aluminium (Alq3) as the electron transporting layer and N,N'-diphenyl-N,N'-bis(3-methylphenyl)-[1,1'-biphenyl]-4,4'-diamine (TPD) as the hole transporting layer, respectively, we fabricate a multi-layered organic light-emitting diode and observe the colour tunable electroluminescence (EL). The dependence of the EL spectra on the applied voltage is investigated in detail, and the recombination mechanism is discussed by considering the variation of the hole-electron recombination region.

  16. Comprehensive utilization of digested residue

    Energy Technology Data Exchange (ETDEWEB)

    Reizhi Shen [Soil and Fertilizer Inst. of Shanghai Academy of Agricultural Sciences (China)

    2000-07-01

    The application history of biogas technology in China covers almost one century. Until the 1980's, people's attention not only focused on the benefit of biogas as people's daily fuel, but also on the comprehensive utilization of digested residues. People are more and more interested in these methods of comprehensive utilization, which has led to many research projects on, among others, ''digested effluent as feed additive for pigs'', ''digested sludge for growing mushroom'', and ''digested effluent as pesticide''. Not only are biogas fermentation, organic waste such as animal manure, crop straw, distillery wastewater and the wastewater from slaughter houses converted to biogas, but also digested residues are very useful with a lot of ''potential value'' and ''special functions'', which will bring far more benefits than biogas alone. Some progress on the comprehensive utilization of digested residues in the past ten years is summarized below. (orig.)

  17. Advanced Gasification By-Product Utilization

    Energy Technology Data Exchange (ETDEWEB)

    Rodney Andrews; Aurora Rubel; Jack Groppo; Brock Marrs; Ari Geertsema; Frank Huggins; M. Mercedes Maroto-Valer; Brandie M. Markley; Zhe Lu; Harold Schobert

    2006-08-31

    With the passing of legislation designed to permanently cap and reduce mercury emissions from coal-fired utilities, it is more important than ever to develop and improve upon methods of controlling mercury emissions. One promising technique is carbon sorbent injection into the flue gas of the coal-fired power plant. Currently, this technology is very expensive as costly commercially activated carbons are used as sorbents. There is also a significant lack of understanding of the interaction between mercury vapor and the carbon sorbent, which adds to the difficulty of predicting the amount of sorbent needed for specific plant configurations. Due to its inherent porosity and adsorption properties as well as on-site availability, carbons derived from gasifiers are potential mercury sorbent candidates. Furthermore, because of the increasing restricted use of landfilling, the coal industry is very interested in finding uses for these materials as an alternative to the current disposal practice. The results of laboratory investigations and supporting technical assessments conducted under DOE Subcontract No. DE-FG26-03NT41795 are reported. This contract was with the University of Kentucky Research Foundation, which supports work with the University of Kentucky Center for Applied Energy Research and The Pennsylvania State University Energy Institute. The worked described was part of a project entitled ''Advanced Gasification By-Product Utilization''. This work involved the development of technologies for the separation and characterization of coal gasification slags from operating gasification units, activation of these materials to increase mercury and nitrogen oxide capture efficiency, assessment of these materials as sorbents for mercury and nitrogen oxides, assessment of the potential for leaching of Hg captured by the carbons, analysis of the slags for cement applications, and characterization of these materials for use as polymer fillers. The

  18. Advanced Gasification By-Product Utilization

    Energy Technology Data Exchange (ETDEWEB)

    Rodney Andrews; Aurora Rubel; Jack Groppo; Brock Marrs; Ari Geertsema; Frank Huggins; M. Mercedes Maroto-Valer; Brandie M. Markley; Zhe Lu; Harold Schobert

    2006-08-31

    With the passing of legislation designed to permanently cap and reduce mercury emissions from coal-fired utilities, it is more important than ever to develop and improve upon methods of controlling mercury emissions. One promising technique is carbon sorbent injection into the flue gas of the coal-fired power plant. Currently, this technology is very expensive as costly commercially activated carbons are used as sorbents. There is also a significant lack of understanding of the interaction between mercury vapor and the carbon sorbent, which adds to the difficulty of predicting the amount of sorbent needed for specific plant configurations. Due to its inherent porosity and adsorption properties as well as on-site availability, carbons derived from gasifiers are potential mercury sorbent candidates. Furthermore, because of the increasing restricted use of landfilling, the coal industry is very interested in finding uses for these materials as an alternative to the current disposal practice. The results of laboratory investigations and supporting technical assessments conducted under DOE Subcontract No. DE-FG26-03NT41795 are reported. This contract was with the University of Kentucky Research Foundation, which supports work with the University of Kentucky Center for Applied Energy Research and The Pennsylvania State University Energy Institute. The worked described was part of a project entitled ''Advanced Gasification By-Product Utilization''. This work involved the development of technologies for the separation and characterization of coal gasification slags from operating gasification units, activation of these materials to increase mercury and nitrogen oxide capture efficiency, assessment of these materials as sorbents for mercury and nitrogen oxides, assessment of the potential for leaching of Hg captured by the carbons, analysis of the slags for cement applications, and characterization of these materials for use as polymer fillers. The

  19. Semi-continuous production of high-activity pectinases by immobilized Rhizopus oryzae using tobacco wastewater as substrate and their utilization in the hydrolysis of pectin-containing lignocellulosic biomass at high solid content.

    Science.gov (United States)

    Zheng, Yu-Xi; Wang, Yuan-Liang; Pan, Jun; Zhang, Jian-Rong; Dai, Ya; Chen, Kun-Yan

    2017-10-01

    In this study, highly reactive endo- and exo-polygalacturonases (PGs) were produced from the tobacco industry wastewater using immobilized Rhizopus oryzae. Compared with free cells, immobilized cells increased enzyme activity 2.8-fold and reduced production time to 24h by shake-flask production. Moreover, the immobilized cells enabled the semi-continuous production of enzymes through repeated-batch mode for seven consecutive cycles in a scale-up bioreactor. During the first five cycles, the average endo-PG and exo-PG activities reached 307.5 and 242.6U/ml, respectively. The addition of crude enzyme for the hydrolysis of pectin-containing lignocellulosic biomass under high-gravity conditions increased glucose release 4.2-fold (115.4 vs. 29.0g/L), compared with hydrolysis using cellulase alone. This process achieves the efficient production of pectin-degrading enzymes, provides a cost-effective method for tobacco wastewater treatment, and offers the possibility to obtain fermentable sugars with high-titer from pectin-containing lignocellulosic biomass, which has important potential for the commercial production of bio-fuels. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Simple utility functions with Giffen demand

    DEFF Research Database (Denmark)

    Sørensen, Peter Norman

    2007-01-01

    Simple utility functions with the Giffen property are presented: locally, the demand curve for a good is upward sloping. The utility functions represent continuous, monotone, convex preferences......Simple utility functions with the Giffen property are presented: locally, the demand curve for a good is upward sloping. The utility functions represent continuous, monotone, convex preferences...

  1. A humanitarian mission in southern Iraq: utilization of the 7th Field Hospital of the Army of the Czech Republic--a report on its medical activities and working conditions.

    Science.gov (United States)

    Chmátal, Petr; Bohonĕk, Milos; Dobiásová, Martina; Hasek, Robert; Cernohous, Miroslav

    2005-06-01

    Between April 24 and September 18, 2003, a total of 7,099 outpatient treatments were performed. Between June 3 and September 18, 2003, a total of 124 patients were surgically treated and 209 patients were hospitalized; the hospital recorded 1,239 bed-days, 137 of them in the intensive care unit. A total of 924 X-ray and ultrasound examinations were performed, as well as 10,014 laboratory tests. Local inhabitants accounted for 90.5% of the patients. In their practice, the doctors encountered a very wide spectrum of surgical and nonsurgical diagnoses. Part of the work was to support humanitarian activities, with supplies of humanitarian material, selection of children for specialized cardiosurgical treatment in the Czech Republic, and blood donations. Work in that unstable region was significantly complicated by the extreme climate and the high security risk.

  2. Aproveitamento da casca de citros na perspectiva de alimentos: prospecção da atividade antibacteriana Utilization of citrus by-products in food perspective: screening of antibacterial activity

    Directory of Open Access Journals (Sweden)

    Carin Gerhardt

    2012-05-01

    export of orange juice. The State of Rio Grande Do Sul is an important producer of citrus. During farming and processing of citrus, tons of residues are generated, with low commercial value and great potential for use in the field of food production. These residues possess many nutrients, pigments and bioactive compounds, as well as low toxicity and cost. There is evidence that the peel of citrus have antibacterial and antifungal activity. In this work, we aim to determine the antibacterial activity of ethanolic extracts of citrus peels in the perspective of disinfection and preservation of food, presenting sustainable and natural alternatives directed at consumers concerned with health. Ethanolic extracts of crude peel of ripe ponkan tangerine (Citrus reticulata Blanco, pomelo (Citrus maxima (Burm. Merr. and rangpur lime (Citrus limonia Osbeck were obtained from ecological family farms. Their antibacterial activities were evaluated regarding Minimal Inhibitory Concentration (MIC and Minimal Bactericidal Concentration (MBC against five different bacterial strains. The rangpur lime extract presented the best antibacterial activity, with about 24 mg.mL-1 MIC and 42 mg.mL-1 MBC for the most resistant strain. Pseudomonas aeruginosa was the most sensitive strain. All ethanolic extracts inhibited or inactivated all tested strains, indicating they could be used as natural alternatives in food disinfection and preservation.

  3. Material degradation - a nuclear utility's view

    Energy Technology Data Exchange (ETDEWEB)

    Spekkens, P. [Ontario Power Generation, Science and Technology Development, Toronto, Ontario (Canada)

    2007-07-01

    Degradation of nuclear plant materials has been responsible for major costs and unit outage time. As such, nuclear utilities are important end users of the information produced by R and D on material degradation. This plenary describes the significance of material degradation for the nuclear utilities, and how utilities use information about material degradation in their short, medium and long term planning activities. Utilities invest in R and D programs to assist them in their business objective of operating safely, reliably and cost competitively. Material degradation impacts all three of these business drivers. Utilities make decisions on life cycle planning, unit refurbishment and 'new build' projects on the basis of their understanding of the behaviour of a variety of materials in a broad range of environments. The R and D being carried out today will determine the future business success of the nuclear utilities. The R and D program needs to be broadly based to include a range of materials, environments and time-frames, particularly any new materials proposed for use in new units. The R and D community needs to help the utility managers make choices that will result in an optimized materials R and D program.

  4. Physics Instruction Utilizing Culture-Based Pedagogy

    Directory of Open Access Journals (Sweden)

    Nerrie E. Malaluan

    2015-11-01

    Full Text Available This research assessed topics in physics where culture-based pedagogy may be utilized and the applicability of Batangueño culture to these topics. It also determined the visual presentations which canbe prepared by teachers to incorporate Batangueñoculture in physics instruction. The end purpose of the study was to develop a teaching guide using culture-based pedagogy to reinforce the student’s learning, and help them achieve high academic performance. Descriptive method was adopted with questionnaire as tool in gathering data. Interviews and focus group discussions were also conducted. Thirty physics teachers in public secondary schools of the Division of Batangas City served as respondents. Purposive sampling was applied in determining the respondents. Frequency, percentage, ranking and weighted mean were statistical tools applied. Findings revealed that the culture-based pedagogy that could be utilized in teaching physics was on topics: Constant and Uniformly Acceleration; Work, Power and Energy; Laws of Motion; Projectile Motion; Heat and Light. Batangueño culture was found applicable in teaching physics. The visual presentations which could be used were pictures, powerpoint and video clips. Moreover, the proposed teaching guide utilizing culture-based pedagogy may be used by teachersto heighten students’ interest and motivation and to attain active participation and high achievement. It may be a reference of employing Batangueño culture in teaching the topics. It was recommended that the output be presented to the school heads and supervisors for their comments and suggestions for enrichment of content and application of culture-based pedagogy not only in science but in other learning areas.

  5. Consulting report on the NASA technology utilization network system

    Science.gov (United States)

    Hlava, Marjorie M. K.

    1992-01-01

    The purposes of this consulting effort are: (1) to evaluate the existing management and production procedures and workflow as they each relate to the successful development, utilization, and implementation of the NASA Technology Utilization Network System (TUNS) database; (2) to identify, as requested by the NASA Project Monitor, the strengths, weaknesses, areas of bottlenecking, and previously unaddressed problem areas affecting TUNS; (3) to recommend changes or modifications of existing procedures as necessary in order to effect corrections for the overall benefit of NASA TUNS database production, implementation, and utilization; and (4) to recommend the addition of alternative procedures, routines, and activities that will consolidate and facilitate the production, implementation, and utilization of the NASA TUNS database.

  6. Saving and Utilizing on Water Resources from Steel Making

    Institute of Scientific and Technical Information of China (English)

    HuLiguang

    2005-01-01

    In this espy, the author gives some presentation of the water saving practices in Baosteel for years. Relying on water saving research program and by means of water utilization analysis, water consumption distribution balance test water from every sequence of production activities, Baosteel promotes the waste saving projects including waster water comprehensive utilization and water loss reduction.At the same time, the water utilization technology analysis work and management work have considerably strengthened and operation of saving on fresh water sources and waster water utilization has been put into practice with the purpose to decrease water loss per ton of steel making, while the quality of water is placed under guarantee, a number of new records of water consumption ratio comes into being constantly.

  7. Vision 2021. The utilities future

    Energy Technology Data Exchange (ETDEWEB)

    Liere, J. van [KEMA, Arnhem (Netherlands)

    1996-12-01

    The electricity industry is gradually making the transition to a free market economy characterized by competition. With the arrival of a more market-oriented structure, the electricity companies have taken measures to reduce costs while retaining reliability and safety of the production and distribution. Today the majority of these efforts are oriented towards optimizing the scope and the structure of the organizations and towards streamlining internal processes in order to improve productivity. Throughout the world, the increasing competition among utilities is accompanied by the unbundling of production, transport, distribution and customer service functions. There is a remarkable similarity between the transitions in the computer industry some years ago (from main frame to personal PC`s) and in the electric utility industry today. The new structure is expected to be less centralized and more dispersed. In the dispersed generation concept the locally deployed power plant must become smaller, more flexible, more efficient and less expensive than today`s power plants. Power generation is gradually changing from a steam cycle (Rankine cycle) via the combined cycle to the gas cycle (Brayton cycle). The fuel used to power the gas turbine is expected to change in the future from high calorific to low calorific gas, generated from biomass, waste, oil residues, blast furnaces, coal, etc. Five new areas to be addressed have been identified that can be characterized as follows: (a) improved utilization of capital-intensive production resources to reduce costs, (b) electrification and the supply of heat to increase sales and market share, (c) sustainable developments to broaden our future resource base, (d) improved efficiency based on the Brayton cycle to increase flexibility, (e) development of energy services with new secondary services to stay in the market. (EG) 10 refs.

  8. Melatonin charge transfer complex with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone: Molecular structure, DFT studies, thermal analyses, evaluation of biological activity and utility for determination of melatonin in pure and dosage forms

    Science.gov (United States)

    Mohamed, Gehad G.; Hamed, Maher M.; Zaki, Nadia G.; Abdou, Mohamed M.; Mohamed, Marwa El-Badry; Abdallah, Abanoub Mosaad

    2017-07-01

    A simple, accurate and fast spectrophotometric method for the quantitative determination of melatonin (ML) drug in its pure and pharmaceutical forms was developed based on the formation of its charge transfer complex with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as an electron acceptor. The different conditions for this method were optimized accurately. The Lambert-Beer's law was found to be valid over the concentration range of 4-100 μg mL- 1 ML. The solid form of the CT complex was structurally characterized by means of different spectral methods. Density functional theory (DFT) and time-dependent density functional theory (TD-DFT) calculations were carried out. The different quantum chemical parameters of the CT complex were calculated. Thermal properties of the CT complex and its kinetic thermodynamic parameters were studied, as well as its antimicrobial and antifungal activities were investigated. Molecular docking studies were performed to predict the binding modes of the CT complex components towards E. coli bacterial RNA and the receptor of breast cancer mutant oxidoreductase.

  9. Optical Isolator Utilizing Surface Plasmons

    Directory of Open Access Journals (Sweden)

    Shinji Yuasa

    2012-05-01

    Full Text Available Feasibility of usage of surface plasmons in a new design of an integrated optical isolator has been studied. In the case of surface plasmons propagating at a boundary between a transition metal and a double-layer dielectric, there is a significant difference of optical loss for surface plasmons propagating in opposite directions. Utilizing this structure, it is feasible to fabricate a competitive plasmonic isolator, which benefits from a broad wavelength operational bandwidth and a good technological compatibility for integration into the Photonic Integrated Circuits (PIC. The linear dispersion relation was derived for plasmons propagating in a multilayer magneto-optical slab.

  10. Direct Utilization of Geothermal Energy

    Directory of Open Access Journals (Sweden)

    John W. Lund

    2010-08-01

    Full Text Available The worldwide application of geothermal energy for direct utilization is reviewed. This paper is based on the world update for direct-use presented at the World Geothermal Congress 2010 in Bali, Indonesia (WGC2010 [1] which also includes material presented at three world geothermal congresses in Italy, Japan and Turkey (WGC95, WGC2000 and WGC2005. This report is based on country update papers prepared for WGC2010 and data from other sources. Final update papers were received from 70 countries of which 66 reported some direct utilization of geothermal energy for WGC2010. Twelve additional countries were added to the list based on other sources of information. The 78 countries having direct utilization of geothermal energy, is a significant increase from the 72 reported in 2005, the 58 reported in 2000, and the 28 reported in 1995. An estimate of the installed thermal power for direct utilization at the end of 2009, reported from WGC2010 is 48,493 MWt, almost a 72 % increased over the 2005 data, growing at a compound rate of 11.4% annually with a capacity factor of 0.28. The thermal energy used is 423,830 TJ/year (117,740 GWh/yr, about a 55% increase over 2005, growing at a compound rate of 9.2% annually. The distribution of thermal energy used by category is approximately 47.2% for ground-source heat pumps, 25.8% for bathing and swimming (including balneology, 14.9% for space heating (of which 85% is for district heating, 5.5% for greenhouses and open ground heating, 2.8% for industrial process heating, 2.7% for aquaculture pond and raceway heating, 0.4% for agricultural drying, 0.5% for snow melting and cooling, and 0.2% for other uses. Energy savings amounted to 250 million barrels (38 million tonnes of equivalent oil annually, preventing 33 million tonnes of carbon and 107 million tonnes of CO2 being release to the atmosphere which includes savings in geothermal heat pump cooling (compared to using fuel oil to generate electricity.

  11. Asymptotics of robust utility maximization

    CERN Document Server

    Knispel, Thomas

    2012-01-01

    For a stochastic factor model we maximize the long-term growth rate of robust expected power utility with parameter $\\lambda\\in(0,1)$. Using duality methods the problem is reformulated as an infinite time horizon, risk-sensitive control problem. Our results characterize the optimal growth rate, an optimal long-term trading strategy and an asymptotic worst-case model in terms of an ergodic Bellman equation. With these results we propose a duality approach to a "robust large deviations" criterion for optimal long-term investment.

  12. Cooling clothing utilizing water evaporation

    DEFF Research Database (Denmark)

    Sakoi, Tomonori; Tominaga, Naoto; Melikov, Arsen Krikor

    2014-01-01

    We developed cooling clothing that utilizes water evaporation to cool the human body and has a mechanism to control the cooling intensity. Clean water was supplied to the outer surface of the T-shirt of the cooling clothing, and a small fan was used to enhance evaporation on this outer surface...... temperature ranging from 27.4 to 30.7 °C to establish a suitable water supply control method. A water supply control method that prevents water accumulation in the T-shirt and water dribbling was validated; this method is established based on the concept of the water evaporation capacity under the applied...

  13. Utilization of Fatliquors by Fungi

    Directory of Open Access Journals (Sweden)

    O. P. Sharma

    1980-04-01

    Full Text Available wenty five fungi isolated from deteriorated finished leathers have been tested to know their relative capacity to utilize the fatliquors viz., raw fish oil, castor oil, fish oil (sulphated, spindle oil turkey red oil and coconut oil. All these fatty substances supported the growth of all the fungi except a few species of Aspergillus, Trichoderma and Drechslera which showed moderate growth. The studies support the contention that fatliquors initially provide a substrate for the growth of fungi on finished leather and its products.

  14. European utilities. What are the advantages, limits and perspectives of the multi-utilities model?; Les utilities europeennes. Quels sont les atouts, les limites et les perspectives du modele multi-utilities?

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-01-01

    Since several years, the European utilities (public service companies) have started a movement of broadening of their offer. They now encompass the overall domain of collective services (mainly electricity, natural gas, wastes and water) to propose global offers. The European utilities also go deeper in their range of offers with the management of fluxes (fluid supplies), of services (energy) and the externalization of infrastructures (cogeneration unit, waste water treatment plants, etc..). The multi-utilities model (association of at least 2 collective services inside a same portfolio of activities) has become a standard. This strategic evolution, implemented since several years in Europe, has been possible thanks to regulation changes: opening of gas and electricity markets to competition, increase of environmental standard requirements, delegation of services. If the multi-utilities concept appears as attractive, several questions remain unanswered: what are the real synergies between collective service activities? Is the multi-utilities model viable? How to finance such a model? How to construct and commercialize global offers? What are the commercial and financial results of the multi-utilities model? What are the alternatives to this model? Which strategic future to the European utilities? This study makes a precise status of the European markets of collective services. It analyzes the strategy of the European groups which have adopted the multi-utilities model and shows the advantages and limits of this strategic model. The study includes an analysis of the financial performances of the 20 main European groups which allows to foresee two scenarios of mid-term evolution for this sector. (J.S.)

  15. Development and validation of reversed phase liquid chromatographic method utilizing ultraviolet detection for quantification of irinotecan (CPT-11) and its active metabolite, SN-38, in rat plasma and bile samples: application to pharmacokinetic studies.

    Science.gov (United States)

    Bansal, Tripta; Awasthi, Anshumali; Jaggi, Manu; Khar, Roop K; Talegaonkar, Sushama

    2008-09-15

    A new, simple, sensitive and specific reversed-phase high performance liquid chromatographic (HPLC) method using ultraviolet detection was developed and validated for the analysis of CPT-11 (lambda(max)=254 nm, 365 nm) and its major active metabolite, SN-38 (lambda(max)=380 nm) in rat plasma and bile. The sample pre-treatment from plasma involved a single protein precipitation step with cold acetonitrile. In case of bile, liquid-liquid extraction with dichloromethane: tert-butyl methyl ether (3:7) was carried out. Topotecan, a structurally related camptothecin, was used as an internal standard. An aliquot of 50 microL was injected onto a C-18 column. The chromatographic separation was achieved by gradient elution consisting of acetonitrile and water (pH 3.0 adjusted with 20% o-phosphoric acid) at a flow rate of 1.0 ml/min. Total run time for each sample was 30 min. All the analytes viz. topotecan, CPT-11, SN-38 were well separated with retention times of 11.4, 13.4 and 15.5 min, respectively. Method was found to be selective, linear (R(2) approximately 0.999), accurate (recovery+/-15%) and precise (<5% C.V.) in the selected concentration ranges for both the analytes. The quantification limit for CPT-11 was 40 ngml(-1) and for SN-38 was 25 ngml(-1). The percent extraction efficiency was approximately 97% for CPT-11 and SN-38 from plasma while extraction recovery of CPT-11 and SN-38 from bile was approximately 70% and approximately 60%, respectively. The method was successfully used to determine plasma and biliary excretion time profiles of CPT-11 and SN-38, following oral and intravenous CPT-11 administration in rats. In the present study, irinotecan showed an absolute bioavailability of 30% as calculated from the pharmacokinetic data.

  16. Assessment of individual dose utilization vs. physician prescribing recommendations for recombinant activated factor VII (rFVIIa) in paediatric and adult patients with congenital haemophilia and alloantibody inhibitors (CHwI): the Dosing Observational Study in Hemophilia (DOSE).

    Science.gov (United States)

    Gruppo, R A; Kessler, C M; Neufeld, E J; Cooper, D L

    2013-07-01

    Recent data from the Dosing Observational Study in Hemophilia diary study has described home treatment with recombinant activated factor VII (rFVIIa) in congenital haemophilia with inhibitors (CHwI). The current analysis compares prescribed and patient/caregiver-reported rFVIIa administration in paediatric and adult CHwI patients in this study. Patients with ≥ 4 bleeding episodes within a 3-month period prescribed rFVIIa as first-line therapy for bleeding episodes were eligible. Patients/caregivers completed a diary for ≥ 90 days or until the patient experienced four bleeds. Initial, total and mean rFVIIa doses reported for each bleeding episode were calculated and compared with the physician-prescribed doses. Of 52 enrolled patients (25 children; 27 adults), 39 (75%) completed the study. Children and adults had similar mean durations of bleeding episodes. Both patient groups were administered higher initial rFVIIa doses for joint bleeds than prescribed: median (range) 215.2 (74.1-400.0) mcg kg(-1) vs. 200.0 (61.0-270.0) mcg kg(-1) for children, and 231.3 (59.3-379.7) mcg kg(-1) vs. 123.0 (81.0-289.0) mcg kg(-1) for adults. The median infused dose for joint bleeds was higher in adults than children (175.2 vs. 148.0 mcg kg(-1) ), but children received significantly more doses per joint bleed than adults (median 6.5 vs. 3.0). The median total dose per joint bleed was higher in children than adults (1248.7 vs. 441.6). For children and adults, both initial and additional doses administered for bleeds were higher than prescribed. Children received higher total doses per bleed due to an increased number of infusions per bleed.

  17. High-utilizing Crohn's disease patients under psychosomatic therapy*

    Directory of Open Access Journals (Sweden)

    Jantschek Günther

    2008-10-01

    Full Text Available Abstract Objective Few studies have been published on health care utilization in Crohn's disease and the influence of psychological treatment on high utilizers. Methods The present sub study of a prospective multi center investigation conducted in 87 of 488 consecutive Crohn's disease (CD patients was designed to investigate the influence of the course of Crohn's disease on health care utilization (hospital days (HD and sick leave days (SLD collected by German insurance companies and to examine the conditions of high-utilizing patients. Predictors of health care utilization should be selected. Based on a standardized somatic treatment, high health care utilizing patients of the psychotherapy and control groups should be compared before and after a one-year treatment. Results Multivariate regression analysis identified disease activity at randomization as an important predictor of the clinical course (r2 = 0.28, p 2 = 0.15, p = 0.09. The patients' level of anxiety, depression and lack of control at randomization predicted their health-related quality of life at the end of the study (r2 = 0.51, p 2 = 0.22, p Among high utilizers, a significantly greater drop in HD (p Conclusion The course of Crohn's disease is influenced by psychological as well as somatic factors; especially depression seems important here. A significant drop of health care utilization demonstrates the benefit of psychological treatment in the subgroup of high-utilizing CD patients. Further studies are needed to replicate the findings of the clinical outcome in this CD subgroup.

  18. 76 FR 17379 - Information Collection Activity; Comment Request

    Science.gov (United States)

    2011-03-29

    ... Rural Utilities Service Information Collection Activity; Comment Request AGENCY: Rural Utilities Service... collection and recordkeeping activities (see 5 CFR 1320.8(d)). This notice identifies an information.... Department of Agriculture (USDA) Rural Development Utilities Programs, invites comments on this...

  19. Utilizing inheritance in requirements engineering

    Science.gov (United States)

    Kaindl, Hermann

    1994-01-01

    The scope of this paper is the utilization of inheritance for requirements specification, i.e., the tasks of analyzing and modeling the domain, as well as forming and defining requirements. Our approach and the tool supporting it are named RETH (Requirements Engineering Through Hypertext). Actually, RETH uses a combination of various technologies, including object-oriented approaches and artificial intelligence (in particular frames). We do not attempt to exclude or replace formal representations, but try to complement and provide means for gradually developing them. Among others, RETH has been applied in the CERN (Conseil Europeen pour la Rechereche Nucleaire) Cortex project. While it would be impossible to explain this project in detail here, it should be sufficient to know that it deals with a generic distributed control system. Since this project is not finished yet, it is difficult to state its size precisely. In order to give an idea, its final goal is to substitute the many existing similar control systems at CERN by this generic approach. Currently, RETH is also tested using real-world requirements for the Pastel Mission Planning System at ESOC in Darmstadt. First, we outline how hypertext is integrated into a frame system in our approach. Moreover, the usefulness of inheritance is demonstrated as performed by the tool RETH. We then summarize our experiences of utilizing inheritance in the Cortex project. Lastly, RETH will be related to existing work.

  20. Hypertext Cross-Reference Utilities

    Science.gov (United States)

    Warren-Smith, R. F.; Draper, P. W.

    This document describes a set of ``Hypertext Cross-Reference Utilities'' (HTX) which are designed to help maintain large documentation sets whose constituent documents are written using the Hypertext Markup Languagee (HTML). The central part of HTX is a hypertext linker, hlink. This allows hyper-links (or cross-references) to be established between related documents in such a way that it is easy to maintain their integrity as individual documents are updated. Information produced by this linking process is also used by other HTX utilities to provide document search facilities and the ability to randomly access any part of a documentation set. This latter capability forms a basis for constructing hypertext help systems for use by other software. The expected readership of this document includes those who read hypertext documentation, those who write it, and those who maintain it, especially those who write and maintain Starlink documentation. Software developers may also be interested in the possibilities for hypertext help that HTX provides.

  1. ADVANCED GASIFICATION BY-PRODUCT UTILIZATION

    Energy Technology Data Exchange (ETDEWEB)

    Rodney Andrews; Aurora Rubel; Jack Groppo; Ari Geertsema; M. Mercedes Maroto-Valer; Zhe Lu; Harold Schobert

    2005-04-01

    The results of laboratory investigations and supporting technical assessments conducted under DOE Subcontract No. DE-FG26-03NT41795 are reported for the period September 1, 2003 to August 31, 2004. This contract is with the University of Kentucky Research Foundation, which supports work with the University of Kentucky Center for Applied Energy Research and The Pennsylvania State University Energy Institute. The worked described was part of a project entitled ''Advanced Gasification By-Product Utilization''. This work involves the development of technologies for the separation and characterization of coal gasification slags from operating gasification units, activation of these materials to increase mercury and nitrogen oxide capture efficiency, assessment of these materials as sorbents for mercury and nitrogen oxides, and characterization of these materials for use as polymer fillers.

  2. TALEN utilization in rice genome modifications.

    Science.gov (United States)

    Li, Ting; Liu, Bo; Chen, Chih Ying; Yang, Bing

    2014-08-15

    Transcription activator-like effector nucleases (TALENs), the newly developed and powerful genetic tools for precise genome editing, are fusion proteins of TAL effectors as DNA binding domains and the cleavage domain of FokI endonuclease. As a pair, the central repeat regions of TALENs determine the DNA binding specificity for the two sub-target sites; and the dimeric non-specific FokI cleavage domains cause a DNA double strand break (DSB) between the bound sequences. In vivo, cells repair the DSBs through either non-homologous end joining (NHEJ) pathway or homologous recombination (HR) pathway. Various methods have been developed for easy and fast assembly of TALEN genes for their utilization in a variety of eukaryotic cells or organisms. Here we present a TALEN-based rice genome modification protocol including constructing modularly assembled TALENs, rice transformation, and mutant screening.

  3. TRW Advanced Slagging Coal Combustor Utility Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    1989-01-01

    The TRW Advanced Slagging Coal Combustor Demonstration Project consists of retrofitting Orange and Rockland (O R) Utility Corporation's Lovett Plant Unit No. 3 with four (4) slagging combustors which will allow the gas/ou desip unit to fire 2.5 sulfur coal. The slogging combustor process will provide NO[sub x] and SO[sub x] emissions that meet NSPS and New York State Envirommental Standards. TRW-CBU scope of work includes the engineering, design and supply of the slogging combustors, coal and limestone feed systems and a control system for these components. During this report period, the design activities for all systems progressed to permit the release of specifications and requests for proposals. Award of contracts for long-delivery items and major equipment are being placed to meet the revised program schedule.

  4. Utilities:Power:Power-Related Utilities at Pipe Spring National Monument, Arizona (Utilities.gdb:Power:utilpnt_power)

    Data.gov (United States)

    National Park Service, Department of the Interior — This feature class represents power-related utilities at Pipe Spring National Monument, Arizona. The utilities were collected using Trimble Global Positioning System...

  5. Advanced Gasification By-Product Utilization

    Energy Technology Data Exchange (ETDEWEB)

    Rodney Andrews; Aurora Rubel; Jack Groppo; Ari Geertsema; Frank Huggins; M. Mercedes Maroto-Valer; Brandie M. Markley; Harold Schobert

    2006-02-01

    With the recent passing of new legislation designed to permanently cap and reduce mercury emissions from coal-fired utilities, it is more important than ever to develop and improve upon methods of controlling mercury emissions. One promising technique is carbon sorbent injection into the flue gas of the coal-fired power plant. Currently, this technology is very expensive as costly commercially activated carbons are used as sorbents. There is also a significant lack of understanding of the interaction between mercury vapor and the carbon sorbent, which adds to the difficulty of predicting the amount of sorbent needed for specific plant configurations. Due to its inherent porosity and adsorption properties as well as on-site availability, carbons derived from gasifiers are potential mercury sorbent candidates. Furthermore, because of the increasing restricted use of landfilling, the coal industry is very interested in finding uses for these materials as an alternative to the current disposal practice. The results of laboratory investigations and supporting technical assessments conducted under DOE Subcontract No. DE-FG26-03NT41795 are reported for the period September 1, 2004 to August 31, 2005. This contract is with the University of Kentucky Research Foundation, which supports work with the University of Kentucky Center for Applied Energy Research and The Pennsylvania State University Energy Institute. The worked described was part of a project entitled ''Advanced Gasification By-Product Utilization''. This work involves the development of technologies for the separation and characterization of coal gasification slags from operating gasification units, activation of these materials to increase mercury and nitrogen oxide capture efficiency, assessment of these materials as sorbents for mercury and nitrogen oxides, and characterization of these materials for use as polymer fillers.

  6. EQ-5D Utilities in Chronic Spontaneous/Idiopathic Urticaria.

    Science.gov (United States)

    Hawe, Emma; McBride, Doreen; Balp, Maria-Magdalena; Tian, Haijun; Halliday, Anna; Stull, Donald E

    2016-05-01

    To obtain utility estimates suitable for use in economic models for chronic spontaneous (idiopathic) urticaria (CSU). Patient-level data from three randomized clinical trials-ASTERIA I, ASTERIA II and GLACIAL-were analysed. Health states were derived from the Urticaria Activity Score over 7 days (UAS7); higher scores denote greater activity. The health state score ranges were urticaria free: 0; well-controlled urticaria: 1-6; mild urticaria: 7-15; moderate urticaria: 16-27; and severe urticaria: 28-42. The mean EQ-5D utilities were calculated for each health state. A mixed model was used to predict the EQ-5D according to UAS7 health states in a pooled data set containing all treatment arms and time points from the three trials. Pooled trial data were validated through visual comparisons and interaction terms. Fixed and random effects for trials and patients were included, along with the following covariates: UAS7 health state at baseline (moderate or severe); presence of angioedema at baseline and during follow-up; duration of CSU; number of previous CSU medications; visit; current treatment; and patient age and sex. There was a consistent improvement in EQ-5D utilities as urticaria activity decreased. The mean utilities ranged from 0.710 (severe urticaria) to 0.780 (moderate urticaria), 0.829 (mild urticaria), 0.862 (well-controlled urticaria) and 0.894 (urticaria free). Sensitivity and subgroup analyses confirmed the robustness of the results. The results suggest that EQ-5D utility scores increase with decreasing urticaria activity. EQ-5D utility scores enable the health-related quality of life of CSU patients to be compared with that of patients with other diseases.

  7. Maximizing utilization of sport halls during peak hours

    DEFF Research Database (Denmark)

    Iversen, Evald Bundgård; Forsberg, Peter

    the number of participants 7.5 persons higher pr. activity compared to club activities. This implies that clubs during peak hours could include more participants. Another possibility to increase utilization is if the management of sport facilities forced sport clubs and other organisers to adapt......BACKGROUNDDuring peak hours (4.30pm-8pm) demand for timeslots in sport halls in Denmark are high and there are few timeslots available. Further, focus on how public resources are spent most efficient is increasing (Iversen, 2013). This makes it interesting to analyse how utilization could...... be increased during peak hours. DATA AND METHODOLOGYData is collected by observation of activities during two weeks on for example whether halls are used or not; the amount of playing field used; and number of participants (Iversen, 2012). Data on 1.331 activities in 36 sport halls across 4 municipalities have...

  8. Advanced clean coal utilization technologies

    Energy Technology Data Exchange (ETDEWEB)

    Moritomi, Hiroshi [National Inst. for Resources and Environment, Tsukuba, Ibaraki (Japan)

    1993-12-31

    The most important greenhouse gas is CO{sub 2} from coal utilization. Ways of mitigating CO{sub 2} emissions include the use of alternative fuels, using renewable resources and increasing the efficiency of power generation and end use. Adding to such greenhouse gas mitigation technologies, post combustion control by removing CO{sub 2} from power station flue gases and then storing or disposing it will be available. Although the post combustion control have to be evaluated in a systematic manner relating them to whether they are presently available technology, to be available in the near future or long term prospects requiring considerable development, it is considered to be a less promising option owing to the high cost and energy penalty. By contrast, abatement technologies aimed at improving conversion efficiency or reducing energy consumption will reduce emissions while having their own commercial justification.

  9. Personal genetics: sports utility vehicle?

    Science.gov (United States)

    Grimaldi, Keith Anthony; Paoli, Antonio; Smith, Graeme John

    2012-12-01

    Personal genetic testing which is not strictly related to medicine or health is becoming more and more popular covering areas from ancestry, genealogy, nutrition& lifestyle and more recently sports and exercise. The reasons are compelling - if it were possible to read in our genes our potential sporting attributes and how to achieve them it would be valuable information. But is it possible? This overview will look at the current situation and future prospects the authors believe that there is utility in sports genetic testing exactly what can be interpreted from our genetic results needs to be precisely defined and limited to what has been demonstrated by repeated scientific studies. Current areas of interest include optimizing exercise/training routines, VO2max improvement and predisposition to some common sports related injuries such as tendonitis. The interest and the scientific progress is reflected both in increasing rate of publication of geneexercise studies as well as in patent applications concerning genetic associations with commercial potential.

  10. Capacity Utilization in European Railways

    DEFF Research Database (Denmark)

    Khadem Sameni, Melody; Landex, Alex

    2013-01-01

    At the strategic level, railways currently use different indices to estimate how ‘value’ is generated by using railway capacity. However, railway capacity is a multidisciplinary area, and attempts to develop various indices cannot provide a holistic measure of operational efficiency. European...... railways are facing a capacity challenge which is caused by passenger and freight demand exceeding the track capacity supply. In the absence of a comprehensive railway capacity manual, methodologies are needed to assess how well railways use their track capacity. This paper presents a novel...... and unprecedented approach for this aim. Relative operational efficiency of 24 European railways in capacity utilization is studied for the first time by data envelopment analysis (DEA). It deviates from previous applications of DEA in the railway industry that are conducted to analyze cost efficiency of railways...

  11. Aspects of carbon dioxide utilization

    Energy Technology Data Exchange (ETDEWEB)

    Omae, Iwao [Omae Research Laboratories, 335-23 Mizuno, Sayama, Saitama 350-1317 (Japan)

    2006-06-30

    Carbon dioxide reacts with hydrogen, alcohols, acetals, epoxides, amines, carbon-carbon unsaturated compounds, etc. in supercritical carbon dioxide or in other solvents in the presence of metal compounds as catalysts. The products of these reactions are formic acid, formic acid esters, formamides, methanol, dimethyl carbonate, alkylene carbonates, carbamic acid esters, lactones, carboxylic acids, polycarbonate (bisphenol-based engineering polymer), aliphatic polycarbonates, etc. Especially, the productions of formic acid, formic acid methyl ester and dimethylformamide with a ruthenium catalyst; dimethyl carbonate and urethanes with a dialkyltin catalyst; 2-pyrone with a nickel-phosphine catalyst; diphenyl carbonate with a lead phenoxide catalyst; the alternating copolymerization of carbon dioxide and epoxides with a zinc catalyst has attracted attentions as the industrial utilizations of carbon dioxide. The further development of these production processes is expected. (author)

  12. Resourceful Utilization of Tannery Wastewater

    Institute of Scientific and Technical Information of China (English)

    Wang Chen; Wang Xikui; Ding Maochen; Zhang Chaoyu

    2012-01-01

    Leather industry is an important light industry in China. Leather making requires a series of chemical treatment. Degreasing, unhairing and chrome tanning wastewaters are the main portions of tannery wastewater. Reclaiming and reusing these wastewaters can eliminate 80% of COD, 75% of BOD, 95% of chromium and 93% of sulfuret, furthermore reduce environment impact, decrease treatment costs, save chemicals and water. Some application methods of wastewater reclamation and reuse for dif- ferent operations were reported. The suitable reclamation and reuse technologies can enable leather making processes more ra- tional, and realize the recovery and recycle of several chemicals in the tannery. Resourceful utilization of tannery wastewater should mate with renovating production technology, updating equipment, and must be guaranteed sufficiently by environmental protection measures.

  13. The Utilization of Home Help in Sweden: A Multivariate Analysis.

    Science.gov (United States)

    Thorslund, Mats; And Others

    1991-01-01

    Estimated effect of variety of factors on the utilization of home help among the elderly in Sweden using a sample (n=421) of people 75 years and older. Results indicated physical functioning (instrumental activities of daily living) and living alone were most important. (Author/ABL)

  14. Differential Availability and Utilization of Agricultural Publications (Haringhata Study).

    Science.gov (United States)

    Dey, P. K.

    1979-01-01

    A study of rural Indian villages was undertaken to determine the availability of agricultural publications and the extent of use by farmers. Low utilization was related to illiteracy, inaccessibility of villages, and lack of government and university extension activity. Recommendations included increasing the publication and distribution of farm…

  15. Radiological Laboratory, Utility, Office Building LEED Strategy & Achievement

    Energy Technology Data Exchange (ETDEWEB)

    Seguin, Nicole R. [Los Alamos National Laboratory

    2012-07-18

    Missions that the Radiological Laboratory, utility, Office Building (RLUOB) supports are: (1) Nuclear Materials Handling, Processing, and Fabrication; (2) Stockpile Management; (3) Materials and Manufacturing Technologies; (4) Nonproliferation Programs; (5) Waste Management Activities - Environmental Programs; and (6) Materials Disposition. The key capabilities are actinide analytical chemistry and material characterization.

  16. Fuel utilization during exercise after 7 days of bed rest

    Science.gov (United States)

    Barrows, Linda H.; Harris, Bernard A.; Moore, Alan D.; Siconolfi, Steven F.

    1992-01-01

    Energy yield from carbohydrate, fat, and protein during physical activity is partially dependent on an individual's fitness level. Prolonged exposure to microgravity causes musculoskeletal and cardiovascular deconditioning; these adaptations may alter fuel utilization during space flight. Carbohydrate and fat metabolism during exercise were analyzed before and after 7 days of horizontal bed rest.

  17. Youth Physical Activity Resources Use and Activity Measured by Accelerometry

    Science.gov (United States)

    Maslow, Andréa L.; Colabianchi, Natalie

    2014-01-01

    Objectives To examine whether utilization of physical activity resources (eg, parks) was associated with daily physical activity measured by accelerometry. Methods 111 adolescents completed a travel diary with concurrent accelerometry. The main exposure was self-reported utilization of a physical activity resource (none/1+ resources). The main outcomes were total minutes spent in daily 1) moderate-vigorous physical activity and 2) vigorous physical activity. Results Utilizing a physical activity resource was significantly associated with total minutes in moderate-vigorous physical activity. African-Americans and males had significantly greater moderate-vigorous physical activity. Conclusions Results from this study support the development and use of physical activity resources. PMID:21204684

  18. Utility Energy Services Contracts Lessons Learned

    Energy Technology Data Exchange (ETDEWEB)

    None

    2001-08-01

    This document describes best practices in the use of Utility Energy Services Contracts. The recommendations were generated by a group of innovative energy managers in many successful projects. The topics include project financing, competition between utility franchises, and water conservation.

  19. Utility Incentives for Combined Heat and Power

    Science.gov (United States)

    This report describes the results of EPA's research and analysis into utility incentives for CHP. It provides information about utility-initiated policies, programs, and incentives for CHP systems, and includes case studies and tools and resources.

  20. Utility Energy Services Contracts: Enabling Documents

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, Karen; Vasquez, Deb

    2017-01-01

    The Federal Energy Management Program's 'Utility Energy Service Contracts: Enabling Documents' provide legislative information and materials that clarify the authority for federal agencies to enter into utility energy service contracts, or UESCs.

  1. 31. FACTORS INFLUENCING UTILIZATION OF INTERMITTENT ...

    African Journals Online (AJOL)

    Esem

    treatment of malaria during pregnancy(IPTp), effective IPTp service utilization ... effective case management of malaria. Despite the ... Factors influencing IPTp utilization identified in the study included; educational status of a woman,. Medical ...

  2. Urban ecology and the municipal utilities

    DEFF Research Database (Denmark)

    Nielsen, Susanne Balslev

    1998-01-01

    Current management of municipal utilities for energy, water and solid waste is often in conflict with the ideas of ecological demonstrationprojects. The writer argue there is a need of transformation within municipal utilities and a need of new planning tools......Current management of municipal utilities for energy, water and solid waste is often in conflict with the ideas of ecological demonstrationprojects. The writer argue there is a need of transformation within municipal utilities and a need of new planning tools...

  3. Active magnetic regenerator

    Science.gov (United States)

    Barclay, John A.; Steyert, William A.

    1982-01-01

    The disclosure is directed to an active magnetic regenerator apparatus and method. Brayton, Stirling, Ericsson, and Carnot cycles and the like may be utilized in an active magnetic regenerator to provide efficient refrigeration over relatively large temperature ranges.

  4. Research Utilization in Social Work Education.

    Science.gov (United States)

    Briar, Scott, Ed.; And Others

    The Project on Research Utilization in Social Work Education established in 1976 is described. There are eight chapters to the report. Chapter 1 describes the project. The broad goals of the project were to: (1) analyze the dynamics of research utilization in social work; (2) identify the obstacles to research utilization, especially those that…

  5. Health utilities of hypertensive patients in Vietnam

    NARCIS (Netherlands)

    Nguyen, T.P.; Postma, M.J.; Veninga, Catharina

    2015-01-01

    Objectives: With a lack of an essential evidence on utilities to support cost-effectiveness analysis of hypertension management in Vietnam, we aimed to gather data on health utilities for hypertensive patients and identify predictors of utility. Methods: Hypertensive patients, from 40 to 80 years ol

  6. 75 FR 4098 - Utility Allowance Adjustments

    Science.gov (United States)

    2010-01-26

    ... URBAN DEVELOPMENT Utility Allowance Adjustments AGENCY: Office of the Chief Information Officer, HUD... are required to advise the Secretary of the need for and request of a new utility allowance for... whether the information will have practical utility; (2) Evaluate the accuracy of the agency's estimate...

  7. 25 CFR 700.105 - Utility charges.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Utility charges. 700.105 Section 700.105 Indians THE OFFICE OF NAVAJO AND HOPI INDIAN RELOCATION COMMISSION OPERATIONS AND RELOCATION PROCEDURES General Policies and Instructions Definitions § 700.105 Utility charges. Utility charges means the cost for...

  8. 10 CFR 34.71 - Utilization logs.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Utilization logs. 34.71 Section 34.71 Energy NUCLEAR... RADIOGRAPHIC OPERATIONS Recordkeeping Requirements § 34.71 Utilization logs. (a) Each licensee shall maintain utilization logs showing for each sealed source the following information: (1) A description, including...

  9. 49 CFR 218.22 - Utility employee.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Utility employee. 218.22 Section 218.22... employee. (a) A utility employee shall be subject to the Hours of Service Act, and the requirements for... parts 217, 219, and 228 of this chapter. (b) A utility employee shall perform service as a member...

  10. 45 CFR 12.12 - Utilization.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Utilization. 12.12 Section 12.12 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION DISPOSAL AND UTILIZATION OF SURPLUS REAL PROPERTY FOR PUBLIC HEALTH PURPOSES § 12.12 Utilization. (a) Where property or any portion thereof is not...

  11. 10 CFR 766.101 - Data utilization.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Data utilization. 766.101 Section 766.101 Energy DEPARTMENT OF ENERGY URANIUM ENRICHMENT DECONTAMINATION AND DECOMMISSIONING FUND; PROCEDURES FOR SPECIAL ASSESSMENT OF DOMESTIC UTILITIES Procedures for Special Assessment § 766.101 Data utilization. DOE shall use...

  12. 45 CFR 650.11 - Utilization reports.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Utilization reports. 650.11 Section 650.11 Public... Utilization reports. Paragraph (h) of the standard Patent Rights clause set forth in § 650.4 obliges grantees “to submit on request periodic reports no more frequently than annually on the utilization of a...

  13. Trends in Utility Green Pricing Programs (2005)

    Energy Technology Data Exchange (ETDEWEB)

    Bird, L.; Brown, E.

    2006-10-01

    This report presents year-end 2005 data on utility green pricing programs, and examines trends in consumer response and program implementation over time. The data in this report, which were obtained via a questionnaire distributed to utility green pricing program managers, can be used by utilities to benchmark the success of their green power programs.

  14. Electric and gas utility marketing of residential energy conservation case studies

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-05-01

    The objective of this research was to obtain information about utility conservation marketing techniques from companies actively engaged in performing residential conservation services. Many utilities currently are offering comprehensive services (audits, listing of contractors and lenders, post-installation inspection, advertising, and performing consumer research). Activities are reported for the following utilities: Niagara Mohawk Power Corporation; Tampa Electric Company; Memphis Light, Gas, and Water Division; Northern States Power-Wisconsin; Public Service Company of Colorado; Arizona Public Service Company; Pacific Gas and Electric Company; Sacramento Municipal Utility District; and Pacific Power and Light Company.

  15. Undergraduate Nursing Students’ Research Activities and Utilization: A Turkish Sample

    Directory of Open Access Journals (Sweden)

    Nurcan Ertu\\u011F

    2014-01-01

    Full Text Available Objetivo: el objetivo de este estudio fue determinar las actividades de investigación y la utilización de los resultados de la investi - gación por parte los estudiantes de enfermería de pregrado. Método: un diseño descriptivo fue utilizado en el estudio que se desarrolló con estudiantes de pregrado de enfermería en dos universidades en Turquía durante el semestre de primavera de 2012. La población estuvo conformada por 216 participantes. Los datos fueron recolectados a través de un cuestionario elaborado por el autor en base a la literatura. Las pruebas de porcentaje, chi-cuadrado y la prueba exacta de Fisher fueron utilizados para evaluar los datos recogidos. Resultados: aproximadamente la mitad de los estudiantes (49,5 % sabían cómo acceder a las publicaciones científicas, pero ninguno de los estudiantes siguen o leen publicaciones científicas. Solo unos pocos estudiantes (4,2 % habían participado en una actividad de investigación científica. Se encontró que el 87,0 % de los estudiantes no utilizan los resultados de la investigación en la práctica clínica. De 216 estudiantes, el 34,4 % no sabe cómo utilizar los resultados de la investigación científica. Conclusiones: la mayoría de los estudiantes no utilizan los resultados de la investigación en la práctica clínica. Falta de conocimiento sobre el uso de la investigación fue la razón más importante para que los estudiantes no utilizaran los resultados de la investigación. Se sugiere que los estudiantes deben ser alentados y apoyados para utilizar los resultados de investigación y realizar investigaciones.

  16. Review of evaluations of utility home-energy-audit programs

    Science.gov (United States)

    Berry, L.; Soderstrom, J.; Hirst, E.; Newman, B.; Weaver, R.

    1981-03-01

    Evaluation efforts of utilities with active home energy audit programs are reviewed to suggest methodologies, issues, and data that can contribute to the development of a comprehensive Residential Conservation Service evaluation plan. On the basis mainly of written reports received from the utilities, findings about customer response to programs are summarized. The topics discussed include: correlates of program penetration rates; use of financing; attitudes toward programs; actions taken; characteristics of participants; and energy savings due to programs. Particular attention is given to three studies (Tennessee Valley Authority, Seattle City Light, and Pacific Gas and Electric) that analyze fuel consumption records as part of the evaluation.

  17. US electric utility demand-side management, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-26

    The report presents comprehensive information on electric power industry demand-side management (DSM) activities in US at the national, regional, and utility levels. Objective is provide industry decision makers, government policy makers, analysts, and the general public with historical data that may be used in understanding DSM as it relates to the US electric power industry. The first chapter, ``Profile: US Electric Utility Demand-Side Management,`` presents a general discussion of DSM, its history, current issues, and a review of key statistics for the year. Subsequent chapters present discussions and more detailed data on energy savings, peak load reductions, and costs attributable to DSM.

  18. Capture and utilization of carbon dioxide with polyethylene glycol

    CERN Document Server

    Yang, Zhen-Zhen; He, Liang-Nian

    2012-01-01

    In this volume, Professor He and his coworkers summarize polyethylene glycol (PEG)-promoted CO2 chemistry on the basis of understanding about phase behavior of PEG/CO2 system and reaction mechanism at molecular level. As PEG could be utilized as a green replacement for organic solvents, phase-transfer catalyst, surfactant, support in various reaction systems, significantly promoting catalytic activity and recovering expensive metal catalysts, particularly regarded as a CO2-philic material, the authors focus on special applications of PEG in CO2 capture and utilization, including PEG-functional

  19. Celss nutrition system utilizing snails

    Science.gov (United States)

    Midorikawa, Y.; Fujii, T.; Ohira, A.; Nitta, K.

    At the 40th IAF Congress in Malaga, a nutrition system for a lunar base CELSS was presented. A lunar base with a total of eight crew members was envisaged. In this paper, four species of plants—rice, soybean, lettuce and strawberry—were introduced to the system. These plants were sufficient to satisfy fundamental nutritional needs of the crew members. The supply of nutrition from plants and the human nutritional requirements could almost be balanced. Our study revealed that the necessary plant cultivation area per crew member would be nearly 40 m 3 in the lunar base. The sources of nutrition considered in the study were energy, sugar, fat, amino acids, inorganic salt and vitamins; however, calcium, vitamin B 2, vitamin A and sodium were found to be lacking. Therefore, a subsystem to supply these elements is of considerable value. In this paper, we report on a study for breeding snails and utilizing meat as food. Nutrients supplied from snails are shown to compensate for the abovementioned lacking elements. We evaluate the snail breeder and the associated food supply system as a subsystem of closed ecological life support system.

  20. Fuel Utilization and Environment Pollution

    Directory of Open Access Journals (Sweden)

    B. S. Soroka

    2007-01-01

    Full Text Available An influence of utilization of various fuel types on the environment pollution has been analyzed taking into account the state and forecast of changes in consumption structure of primary energy in the world.The regional peculiarities of the environment impact have been studied methodically (regarding the Ukraine as an example: distribution of the harmful effluents has been considered in various regions of the country and inter-relations of some branches of national economy and industry with the atmosphere pollution have been examined.The CO2 effluent distribution within the European regions has been considered as the main greenhouse gas. It has been stated that the difference of the specific CO2 effluent yield per unit of GDP makes more than an order by value between some European countries.This index becomes higher if specific GDP of the country concerned is lower and portion of extractive industries, metallurgical and fuel-power complexes is higher in the country’s economy.