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Sample records for activation analysis method

  1. Analysis of Precision of Activation Analysis Method

    DEFF Research Database (Denmark)

    Heydorn, Kaj; Nørgaard, K.

    1973-01-01

    The precision of an activation-analysis method prescribes the estimation of the precision of a single analytical result. The adequacy of these estimates to account for the observed variation between duplicate results from the analysis of different samples and materials, is tested by the statistic T......, which is shown to be approximated by a χ2 distribution. Application of this test to the results of determinations of manganese in human serum by a method of established precision, led to the detection of airborne pollution of the serum during the sampling process. The subsequent improvement in sampling...... conditions was shown to give not only increased precision, but also improved accuracy of the results....

  2. Digital methods of photopeak integration in activation analysis.

    Science.gov (United States)

    Baedecker, P. A.

    1971-01-01

    A study of the precision attainable by several methods of gamma-ray photopeak integration has been carried out. The 'total peak area' method, the methods proposed by Covell, Sterlinski, and Quittner, and some modifications of these methods have been considered. A modification by Wasson of the total peak area method is considered to be the most advantageous due to its simplicity and the relatively high precision obtainable with this technique. A computer routine for the analysis of spectral data from nondestructive activation analysis experiments employing a Ge(Li) detector-spectrometer system is described.

  3. Activity optimization method in SPECT: A comparison with ROC analysis

    Institute of Scientific and Technical Information of China (English)

    D(I)AZ Marlén Pérez; RIZO Oscar Díaz; D(I)AZ Adlin López; APARICIO Eric Estévez; D(I)AZ Reinaldo Roque

    2006-01-01

    A discriminant method for optimizing activity in nuclear medicine studies is validated by comparison with ROC performed with a cardiac phantom. Three different lesions (L1, L2 and L3) were placed in the myocardium-wall by pairs for each SPECT. Three activities (84, 37 or 18.5 MBq) of 99mTc were used as background. Linear discriminant analysis was used to select the parameters that characterize image quality among the measured variables in the images [(Background-to-Lesion (B/Li) and Signal-to-Noise (Si/N) ratio s)]. Two clusters with different image quality (P=0.021) were obtained. The ratios B/L1, B/L2 and B/L3are the parameters used to construct the function with 100% of cases correctly classified into the clusters. The value of 37 MBq was the lowest tested activity for which good results for the B/Li ratios were obtained. The result coincides with the applied ROC-analysis (r=0.89).

  4. Structural Analysis Extended with Active Fault Isolation - Methods and Algorithms

    DEFF Research Database (Denmark)

    Gelso, Esteban R.; Blanke, Mogens

    2009-01-01

    on system inputs can considerably enhance fault isolability. This paper investigates this possibility of active fault isolation from a structural point of view. While such extension of the structural analysis approach was suggested earlier, algorithms and case studies were needed to explore this theory....... The paper develops algorithms for investigation of the possibilities of active structural isolation and it offers illustrative examples and a larger case study to explore the properties of active structural isolability ideas....

  5. Tensor analysis methods for activity characterization in spatiotemporal data

    Energy Technology Data Exchange (ETDEWEB)

    Haass, Michael Joseph; Van Benthem, Mark Hilary; Ochoa, Edward M

    2014-03-01

    Tensor (multiway array) factorization and decomposition offers unique advantages for activity characterization in spatio-temporal datasets because these methods are compatible with sparse matrices and maintain multiway structure that is otherwise lost in collapsing for regular matrix factorization. This report describes our research as part of the PANTHER LDRD Grand Challenge to develop a foundational basis of mathematical techniques and visualizations that enable unsophisticated users (e.g. users who are not steeped in the mathematical details of matrix algebra and mulitway computations) to discover hidden patterns in large spatiotemporal data sets.

  6. Analysis of Solar Magnetic Activity with the Wavelet Coherence Method

    Science.gov (United States)

    Velasco, V. M.; Perez-Peraza, J. A.; Mendoza, B. E.; Valdes-Galicia, J. F.; Sosa, O.; Alvarez-Madrigal, M.

    2007-05-01

    The origin, behavior and evolution of the solar magnetic field is one of the main challenges of observational and theoretical solar physics. Up to now the Dynamo theory gives us the best approach to the problem. However, it is not yet able to predict many features of the solar activity, which seems not to be strictly a periodical phenomenon. Among the indicators of solar magnetic variability there is the 11-years cycle of sunspots, as well as the solar magnetic cycle of 22 years (the Hale cycle). In order to provide more elements to the Dynamo theory that could help it in the predicting task, we analyze here the plausible existence of other periodicities associated with the solar magnetic field. In this preliminary work we use historical data (sunspots and aurora borealis), proxies (Be10 and C14) and modern instrumental data (Coronal Holes, Cosmic Rays, sunspots, flare indexes and solar radio flux at 10.7 cm). To find relationships between different time-frequency series we have employed the t Wavelet Coherence technique: this technique indicates if two time-series of solar activity have the same periodicities in a given time interval. If so, it determines whether such relation is a linear one or not. Such a powerful tool indicates that, if some periodicity at a given frequency has a confidence level below 95%, it appears very lessened or does not appear in the Wavelet Spectral Analysis, such periodicity does not exist . Our results show that the so called Glaisberg cycle of 80-90 years and the periodicity of 205 years (the Suess cycle) do not exist . It can be speculated that such fictitious periodicities hav been the result of using the Fourier transform with series with are not of stationary nature, as it is the case of the Be10 and C14 series. In contrast we confirm the presence of periodicities of 1.3, 1.7, 3.5, 5.5, 7, 60, 120 and 240 years. The concept of a Glaisberg cycle falls between those of 60 and 120 years. We conclude that the periodicity of 120 years

  7. Film analysis of activated sludge microbial discs by the Taguchi method and grey relational analysis.

    Science.gov (United States)

    Chen, M Y; Syu, M J

    2003-12-01

    A biofilm model with substrate inhibition is proposed for the activated sludge growing discs of rotating biological contactor (RBC); this model is different from the steady-state biofilm model based on the Monod assumption. Both deep and shallow types of biofilms are examined and discussed. The biofilm models based on both Monod and substrate inhibition (Haldane) assumptions are compared. In addition, the relationships between substrate utilization rate, biofilm thickness, and liquid phase substrate concentration are discussed. The influence order of the factors that affect the biofilm thickness is studied and discussed by combining the Taguchi method and grey relational analysis. In this work, a Taguchi orthogonal table is used to construct the series that is needed for grey relational analysis to determine the influence priority of the four parameters S(B), kX(f), K(s), and K(i).

  8. [Use of the recurrence plot method in stochastic analysis of neuronal activity].

    Science.gov (United States)

    Novák, V; Schmidt, J

    1996-09-01

    The recurrence plot method is described together with its application to the analysis of inner time relations in the sequences of interspike intervals. The depicted method was employed to analyze results from the computer model of the neuronal stochastic activity. It can be also used to analyze sequences of interspike intervals in the records from life neurons.

  9. Comparative Analysis Of Conventional Method With Activity Based Costing In PT Mulia Sejati Gallery

    Directory of Open Access Journals (Sweden)

    Irma Nadia Erena

    2016-09-01

    Full Text Available The goal of this research was to provide readers the information about the calculation methods, both traditional and activity-based costing in the application of the cost of production. The method used in this research was the qualitative method. The analysis was done by calculating the amount of the production cost using the traditional system and the magnitude of the production cost when using the activity-based costing system. The amount of each acquisition was then performed into data analysis. The results achieved are massive distortion between the calculations using traditional systems and activity based costing system. The conclusions of the whole thesis are activity-based costing system is considered more relevant than traditional systems that are currently used by the company.

  10. [The activity of Codex Alimentarius Commission FAO/WHO Committee on Methods of Analysis and Sampling].

    Science.gov (United States)

    Jedrzejczak, Renata; Brulińska-Ostrowska, Elzbieta; Traczyk, Iwona

    2004-01-01

    In the light of issues discussed during 24th Session of Codex Committee on Methods of Analysis and Sampling that was held in Budapest, 18-22 November 2002, the current activity of this Committee is presented. More detailed information about some of the most advanced or interesting documents is included, i. e. Proposed Draft General Guidelines On Sampling, Harmonized IUPAC Guidelines for Single-Laboratory Validation of Methods of Analysis, Consideration of methods for the detection and identification of food derived from biotechnology.

  11. Activated region fitting: a robust high-power method for fMRI analysis using parameterized regions of activation.

    Science.gov (United States)

    Weeda, Wouter D; Waldorp, Lourens J; Christoffels, Ingrid; Huizenga, Hilde M

    2009-08-01

    An important issue in the analysis of fMRI is how to account for the spatial smoothness of activated regions. In this article a method is proposed to accomplish this by modeling activated regions with Gaussian shapes. Hypothesis tests on the location, spatial extent, and amplitude of these regions are performed instead of hypothesis tests of individual voxels. This increases power and eases interpretation. Simulation studies show robust hypothesis tests under misspecification of the shape model, and increased power over standard techniques especially at low signal-to-noise ratios. An application to real single-subject data also indicates that the method has increased power over standard methods.

  12. ANALYSIS OF INNOVATIVE ACTIVITY OF METALLURGICAL COMPANIES USING MONTE-CARLO MATHEMATICAL MODEL-ING METHOD

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    Shchekoturova S. D.

    2015-04-01

    Full Text Available The article presents an analysis of an innovative activity of four Russian metallurgical enterprises: "Ruspolimet", JSC "Ural Smithy", JSC "Stupino Metallurgical Company", JSC "VSMPO" via mathematical modeling using Monte Carlo method. The results of the assessment of innovative activity of Russian metallurgical companies were identified in five years dynamics. An assessment of the current innovative activity was made by the calculation of an integral index of the innovative activity. The calculation was based on such six indicators as the proportion of staff employed in R & D; the level of development of new technology; the degree of development of new products; share of material resources for R & D; degree of security of enterprise intellectual property; the share of investment in innovative projects and it was analyzed from 2007 to 2011. On the basis of this data the integral indicator of the innovative activity of metallurgical companies was calculated by well-known method of weighting coefficients. The comparative analysis of integral indicators of the innovative activity of considered companies made it possible to range their level of the innovative activity and to characterize the current state of their business. Based on Monte Carlo method a variation interval of the integral indicator was obtained and detailed instructions to choose the strategy of the innovative development of metallurgical enterprises were given as well

  13. Performance Analysis of Transfer function Based Active Noise Cancellation Method Using Evolutionary Algorithm

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    Prof. Vikas Gupta

    2014-01-01

    Full Text Available Due to the exponential increase of noise pollution, the demand for noise controlling system is also increases. Basically two types of techniques are used for noise cancellation active and passive. But passive techniques are inactive for low frequency noise, hence there is an increasing demand of research and developmental work on active noise cancellation techniques. In this paper we introduce a new method in the active noise cancellation system. This new method is the transfer function based method which used Genetic and Particle swarm optimization (PSO algorithm for noise cancellation. This method is very simple and efficient for low frequency noise cancellation. Here we analysis the performance of this method in the presence of white Gaussian noise and compare the results of Particle swarm optimization (PSO and Genetic algorithm. Both algorithms are suitable for different environment, so we observe their performance in different fields. In this paper a comparative study of Genetic and Particle swarm optimization (PSO is described with proper results. It will go in depth what exactly transfer function method, how it work and advantages over neural network based method

  14. Validation of spectrophotometric microplate methods for polyphenol oxidase and peroxidase activities analysis in fruits and vegetables

    Directory of Open Access Journals (Sweden)

    Érica Sayuri SIGUEMOTO

    Full Text Available Abstract Enzymes polyphenol oxidase (PPO and peroxidase (POD play important roles in the processing of fruits and vegetables, since they can produce undesirable changes in color, texture and flavor. Classical methods of activity assessment are based on cuvette spectrophotometric readings. This work aims to propose, to validate and to test microplate spectrophotometric methods. Samples of apple juice and lyophilized enzymes from mushroom and horseradish were analyzed by the cuvette and microplate methods and it was possible to validate the microplate assays with satisfactory results regarding linearity, repeatability, accuracy along with quantitation and detection limits. The proposed microplate methods proved to be reliable and reproducible as the classical methods besides having the advantages of allowing simultaneous analysis and requiring a reduced amount of samples and reactants, which can beneficial to the study of enzyme inactivation in the processing of fruits and vegetables.

  15. Serum 5'nucleotidase activity in rats: a method for automated analysis and criteria for interpretation.

    Science.gov (United States)

    Carakostas, Michael C.; Power, Richard J.; Banerjee, Asit K.

    1990-01-01

    A manual kit for determining serum 5'nucleotidase (5'NT, EC 3.1.3.5) activity was adapted for use with rat samples on a large discrete clinical chemistry analyzer. The precision of the method was good (within-run C.V. = 2.14%; between-run C.V. = 5.5%). A comparison of the new automated method with a manual and semi-automated method gave regression statistics of y = 1.18X -3.66 (Sy. x = 4.54), and y = 0.733X + 1.97 (Sy. x = 1.69), respectively. Temperature conversion factors provided by the kit manufacturer for human samples were determined to be inaccurate for converting results from rat samples. Analysis of components contributing to normal variation in rat serum 5'NT activity showed age and sex to be major factors. Increased serum 5'NT activity was observed in female rats when compared to male rats beginning at about 5 to 6 weeks of age. An analysis of variance of serum 5'NT, alkaline phosphatase, and GGT activities observed over a 9-week period in normal rats suggests several advantages for 5'NT as a predictor of biliary lesions in rats.

  16. [Activity and cost analysis in surgical pathology. Experience of a French university laboratory using the activity-based costing method].

    Science.gov (United States)

    Bellocq, J P; Biron, N; Kessler, S; Penaud, M; Faujour, V; Ospel, J; Supper, E; Barthel, A; Roussel, J F; Méchine-Neuville, A; Marcellin, L; Lang-Avérous, G; Chenard, M P

    2001-06-01

    Good self-knowledge enables us to have a well- reasoned adaptation to our environment. Starting from this precept based on simple common sense, activity and cost analysis, when applied to medical departments in a university hospital setting, represents a necessary phase in their scientific progression and in the continuation of their university vocation. This is all the more true given the present climate of economic and organizational restructuring of medical facilities. This paper relates the experience of a French surgical pathology department which was assessed for cost effectiveness using the Activity-Based Costing (ABC) method in 1999. This method, which originated in the business world and of which the general concepts are presented here, has given us a keener understanding of the diverse processes involved, their costs and how these costs are arrived at. Moreover, this method has identified the proportion of costs imputable to diagnostic work and of those linked to work specific to a university hospital, in particular teaching and research and development. The results can then be used for a clearer analysis of the figures required by prescribers and health care funding agencies, and, within the department, to enhance perception of work carried out by the entire staff in order to initiate a new type of management centered on activity (Activity-Based Management). Adaptable to any medical department, whatever its organizational structure, independent of the significance of any given code letter and regardless of the rating method used to grade activities, the ABC method also allows for comparisons between structures of a similar nature. The thoughts it inspires on economic performance must take into account the rules of good medical practice, the imperatives of quality assurance, the need for "breathing space" which are indispensable to research and a humanist conception of working relations.

  17. a Three-Step Spatial-Temporal Clustering Method for Human Activity Pattern Analysis

    Science.gov (United States)

    Huang, W.; Li, S.; Xu, S.

    2016-06-01

    How people move in cities and what they do in various locations at different times form human activity patterns. Human activity pattern plays a key role in in urban planning, traffic forecasting, public health and safety, emergency response, friend recommendation, and so on. Therefore, scholars from different fields, such as social science, geography, transportation, physics and computer science, have made great efforts in modelling and analysing human activity patterns or human mobility patterns. One of the essential tasks in such studies is to find the locations or places where individuals stay to perform some kind of activities before further activity pattern analysis. In the era of Big Data, the emerging of social media along with wearable devices enables human activity data to be collected more easily and efficiently. Furthermore, the dimension of the accessible human activity data has been extended from two to three (space or space-time) to four dimensions (space, time and semantics). More specifically, not only a location and time that people stay and spend are collected, but also what people "say" for in a location at a time can be obtained. The characteristics of these datasets shed new light on the analysis of human mobility, where some of new methodologies should be accordingly developed to handle them. Traditional methods such as neural networks, statistics and clustering have been applied to study human activity patterns using geosocial media data. Among them, clustering methods have been widely used to analyse spatiotemporal patterns. However, to our best knowledge, few of clustering algorithms are specifically developed for handling the datasets that contain spatial, temporal and semantic aspects all together. In this work, we propose a three-step human activity clustering method based on space, time and semantics to fill this gap. One-year Twitter data, posted in Toronto, Canada, is used to test the clustering-based method. The results show that the

  18. A THREE-STEP SPATIAL-TEMPORAL-SEMANTIC CLUSTERING METHOD FOR HUMAN ACTIVITY PATTERN ANALYSIS

    Directory of Open Access Journals (Sweden)

    W. Huang

    2016-06-01

    Full Text Available How people move in cities and what they do in various locations at different times form human activity patterns. Human activity pattern plays a key role in in urban planning, traffic forecasting, public health and safety, emergency response, friend recommendation, and so on. Therefore, scholars from different fields, such as social science, geography, transportation, physics and computer science, have made great efforts in modelling and analysing human activity patterns or human mobility patterns. One of the essential tasks in such studies is to find the locations or places where individuals stay to perform some kind of activities before further activity pattern analysis. In the era of Big Data, the emerging of social media along with wearable devices enables human activity data to be collected more easily and efficiently. Furthermore, the dimension of the accessible human activity data has been extended from two to three (space or space-time to four dimensions (space, time and semantics. More specifically, not only a location and time that people stay and spend are collected, but also what people “say” for in a location at a time can be obtained. The characteristics of these datasets shed new light on the analysis of human mobility, where some of new methodologies should be accordingly developed to handle them. Traditional methods such as neural networks, statistics and clustering have been applied to study human activity patterns using geosocial media data. Among them, clustering methods have been widely used to analyse spatiotemporal patterns. However, to our best knowledge, few of clustering algorithms are specifically developed for handling the datasets that contain spatial, temporal and semantic aspects all together. In this work, we propose a three-step human activity clustering method based on space, time and semantics to fill this gap. One-year Twitter data, posted in Toronto, Canada, is used to test the clustering-based method. The

  19. Influence analysis of time delay to active mass damper control system using pole assignment method

    Science.gov (United States)

    Teng, J.; Xing, H. B.; Lu, W.; Li, Z. H.; Chen, C. J.

    2016-12-01

    To reduce the influence of time delay on the Active Mass Damper (AMD) control systems, influence analysis of time delay on system poles and stability is applied in the paper. A formula of the maximum time delay for ensuring system stability is established, by which the influence analysis of control gains on system stability is further arisen. In addition, the compensation controller is designed based on the given analysis results and pole assignment. A numerical example and an experiment are illustrated to verify that the performance of time-delay system. The result is consistent to that of the long-time delay control system, as well as to proof the better effectiveness of the new method proposed in this article.

  20. Multi-Level Discourse Analysis in a Physics Teaching Methods Course from the Psychological Perspective of Activity Theory

    Science.gov (United States)

    Vieira, Rodrigo Drumond; Kelly, Gregory J.

    2014-01-01

    In this paper, we present and apply a multi-level method for discourse analysis in science classrooms. This method is based on the structure of human activity (activity, actions, and operations) and it was applied to study a pre-service physics teacher methods course. We argue that such an approach, based on a cultural psychological perspective,…

  1. Multi-Level Discourse Analysis in a Physics Teaching Methods Course from the Psychological Perspective of Activity Theory

    Science.gov (United States)

    Vieira, Rodrigo Drumond; Kelly, Gregory J.

    2014-01-01

    In this paper, we present and apply a multi-level method for discourse analysis in science classrooms. This method is based on the structure of human activity (activity, actions, and operations) and it was applied to study a pre-service physics teacher methods course. We argue that such an approach, based on a cultural psychological perspective,…

  2. Analysis of zirconium and nickel based alloys and zirconium oxides by relative and internal monostandard neutron activation analysis methods

    Energy Technology Data Exchange (ETDEWEB)

    Shinde, Amol D.; Acharya, Raghunath; Reddy, Annareddy V. R. [Bhabha Atomic Research Centre, Mumbai (India)

    2017-04-15

    The chemical characterization of metallic alloys and oxides is conventionally carried out by wet chemical analytical methods and/or instrumental methods. Instrumental neutron activation analysis (INAA) is capable of analyzing samples nondestructively. As a part of a chemical quality control exercise, Zircaloys 2 and 4, nimonic alloy, and zirconium oxide samples were analyzed by two INAA methods. The samples of alloys and oxides were also analyzed by inductively coupled plasma optical emission spectroscopy (ICP-OES) and direct current Arc OES methods, respectively, for quality assurance purposes. The samples are important in various fields including nuclear technology. Samples were neutron irradiated using nuclear reactors, and the radioactive assay was carried out using high-resolution gamma-ray spectrometry. Major to trace mass fractions were determined using both relative and internal monostandard (IM) NAA methods as well as OES methods. In the case of alloys, compositional analyses as well as concentrations of some trace elements were determined, whereas in the case of zirconium oxides, six trace elements were determined. For method validation, British Chemical Standard (BCS)-certified reference material 310/1 (a nimonic alloy) was analyzed using both relative INAA and IM-NAA methods. The results showed that IM-NAA and relative INAA methods can be used for nondestructive chemical quality control of alloys and oxide samples.

  3. Development of Distinction Method of Production Area of Ginsengs by Using a Neutron Activation Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Jin; Chung, Yong Sam; Sun, Gwang Min; Lee, Yu Na; Yoo, Sang Ho [KAERI, Daejeon (Korea, Republic of)

    2010-05-15

    Distinction of production area of Korean ginsengs has been tried by using neutron activation techniques such as an instrumental neutron activation analysis (INAA) and a prompt gamma activation analysis (PGAA). A distribution of elements has varied according to the part of plant clue to the difference of enrichment effect and influence from a soil where the plants have been grown. So correlation study between plants and soil has been an Issue. In this study, the distribution of trace elements within a Korean ginseng was investigated by using an instrumental neutron activation analysis

  4. Sesquiterpene Lactones from Artemisia Genus: Biological Activities and Methods of Analysis

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    Bianca Ivanescu

    2015-01-01

    Full Text Available Sesquiterpene lactones are a large group of natural compounds, found primarily in plants of Asteraceae family, with over 5000 structures reported to date. Within this family, genus Artemisia is very well represented, having approximately 500 species characterized by the presence of eudesmanolides and guaianolides, especially highly oxygenated ones, and rarely of germacranolides. Sesquiterpene lactones exhibit a wide range of biological activities, such as antitumor, anti-inflammatory, analgesic, antiulcer, antibacterial, antifungal, antiviral, antiparasitic, and insect deterrent. Many of the biological activities are attributed to the α-methylene-γ-lactone group in their molecule which reacts through a Michael-addition with free sulfhydryl or amino groups in proteins and alkylates them. Due to the fact that most sesquiterpene lactones are thermolabile, less volatile compounds, they present no specific chromophores in the molecule and are sensitive to acidic and basic mediums, and their identification and quantification represent a difficult task for the analyst. Another problematic aspect is represented by the complexity of vegetal samples, which may contain compounds that can interfere with the analysis. Therefore, this paper proposes an overview of the methods used for the identification and quantification of sesquiterpene lactones found in Artemisia genus, as well as the optimal conditions for their extraction and separation.

  5. METHODS AND MODELS FOR ANALYSIS OF THE ORGANIZATIONAL ECONOMICS ACTIVITY USED FOR DEVELOPMENT OF INFORMATICS SYSTEMS

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    TEODORA VĂTUIU

    2014-10-01

    Full Text Available Study of organizational activity and highlighting problem situations that require specific solutions, require a detailed analysis of the models defined for the real system of the economic companies, regarded not as a sum of assets, but as organizations in which there are activities related into processes. In addition to the usual approach of using modeling languages in the development of information systems, in this paper we intend to present some examples that demonstrate the usefulness of a standard modeling language (UML to analyze organizational activities and to report problem situations that may occur in data management registered on primary documents or in processes that bring together activities. Examples that have been focused on a travel agency can be extrapolated to any other organization, and the diagrams can be used in different contexts, depending on the complexity of the activities identified.

  6. An open source cryostage and software analysis method for detection of antifreeze activity

    DEFF Research Database (Denmark)

    Lørup Buch, Johannes; Ramløv, H

    2016-01-01

    The aim of this study is to provide the reader with a simple setup that can detect antifreeze proteins (AFP) by inhibition of ice recrystallisation in very small sample sizes. This includes an open source cryostage, a method for preparing and loading samples as well as a software analysis method....... The entire setup was tested using hyperactive AFP from the cerambycid beetle, Rhagium mordax. Samples containing AFP were compared to buffer samples, and the results are visualised as crystal radius evolution over time and in absolute change over 30 min. Statistical analysis showed that samples containing...... AFP could reliably be told apart from controls after only two minutes of recrystallisation. The goal of providing a fast, cheap and easy method for detecting antifreeze proteins in solution was met, and further development of the system can be followed at https://github.com/pechano/cryostage....

  7. An open source cryostage and software analysis method for detection of antifreeze activity.

    Science.gov (United States)

    Buch, J L; Ramløv, H

    2016-06-01

    The aim of this study is to provide the reader with a simple setup that can detect antifreeze proteins (AFP) by inhibition of ice recrystallisation in very small sample sizes. This includes an open source cryostage, a method for preparing and loading samples as well as a software analysis method. The entire setup was tested using hyperactive AFP from the cerambycid beetle, Rhagium mordax. Samples containing AFP were compared to buffer samples, and the results are visualised as crystal radius evolution over time and in absolute change over 30 min. Statistical analysis showed that samples containing AFP could reliably be told apart from controls after only two minutes of recrystallisation. The goal of providing a fast, cheap and easy method for detecting antifreeze proteins in solution was met, and further development of the system can be followed at https://github.com/pechano/cryostage.

  8. Analysis of cat oocyte activation methods for the generation of feline disease models by nuclear transfer

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    Herrick Jason R

    2009-12-01

    Full Text Available Abstract Background Somatic cell nuclear transfer in cats offers a useful tool for the generation of valuable research models. However, low birth rates after nuclear transfer hamper exploitation of the full potential of the technology. Poor embryo development after activation of the reconstructed oocytes seems to be responsible, at least in part, for the low efficiency. The objective of this study was to characterize the response of cat oocytes to various stimuli in order to fine-tune existing and possibly develop new activation methods for the generation of cat disease models by somatic cell nuclear transfer. Methods First, changes in the intracellular free calcium concentration [Ca2+]i in the oocytes induced by a number of artificial stimuli were characterized. The stimuli included electroporation, ethanol, ionomycin, thimerosal, strontium-chloride and sodium (Na+-free medium. The potential of the most promising treatments (with or without subsequent incubation in the presence of cycloheximide and cytochalasin B to stimulate oocyte activation and support development of the resultant parthenogenetic embryos was then evaluated. Finally, the most effective methods were selected to activate oocytes reconstructed during nuclear transfer with fibroblasts from mucopolysaccharidosis I- and alpha-mannosidosis-affected cats. Results All treatments were able to elicit a [Ca2+]i elevation in the ooplasm with various characteristics. Pronuclear formation and development up to the blastocyst stage was most efficiently triggered by electroporation (60.5 +/- 2.9 and 11.5 +/- 1.7% and the combined thimerosal/DTT treatment (67.7 +/- 1.8 and 10.6 +/- 1.9%; incubation of the stimulated oocytes with cycloheximide and cytochalasin B had a positive effect on embryo development. When these two methods were used to activate oocytes reconstructed during nuclear transfer, up to 84.9% of the reconstructed oocytes cleaved. When the 2 to 4-cell embryos (a total of 220 were

  9. Analysis of active islanding detection methods for grid-connected microinverters for renewable energy processing

    Energy Technology Data Exchange (ETDEWEB)

    Trujillo, C.L. [Grupo de Sistemas Electronicos Industriales del Departamento de Ingenieria Electronica, Universidad Politecnica de Valencia, Camino de Vera S/N, C.P. 46022, Valencia (Spain); Departamento de Ingenieria Electronica, Universidad Distrital Francisco Jose de Caldas, Carrera 7 N 40-53 Piso 5, Bogota (Colombia); Velasco, D.; Figueres, E.; Garcera, G. [Grupo de Sistemas Electronicos Industriales del Departamento de Ingenieria Electronica, Universidad Politecnica de Valencia, Camino de Vera S/N, C.P. 46022, Valencia (Spain)

    2010-11-15

    This paper presents the analysis and comparison of the main active techniques for islanding detection used in grid-connected microinverters for power processing of renewable energy sources. These techniques can be classified into two classes: techniques introducing positive feedback in the control of the inverter and techniques based on harmonics injection. Accurate PSIM trademark simulations have been carried out in order to perform a comparative analysis of the techniques under study and to establish their advantages and disadvantages according to IEEE standards. (author)

  10. Methods of analysis of physical activity among persons with spinal cord injury: A review

    Directory of Open Access Journals (Sweden)

    Jarmila Štěpánová

    2016-11-01

    Full Text Available Background: A spinal cord injury is one of the most devastating acquired physical disabilities. People with spinal cord injury are usually in a productive age, often interested in sports and physical activity. Therefore it is essential to support the development of monitoring of the quality and quantity of physical activity of people with spinal cord injury. Objective: The aim of this study was to perform systematic review of international studies from the period 2004-2014 with the aim to find appropriate questionnaires focused on the subjective perception of the amount of physical activity of persons with spinal cord injury (SCI to be used in The Czech Republic. Methods: A systematic literature review incorporated the databases of Medline, SPORTDiscus, Ebsco and PSYCInfo. Results: This type of questionnaire has not been used previously in the Czech Republic yet the following international surveys have been used: 1. Physical Activity Scale for Individuals with Physical Disabilities (PASIPD, 2. The Physical Activity Recall Assessment for People with Spinal Cord Injury (PARA-SCI, 3. Leisure Time Physical Activity Questionnaire for People with Spinal Cord Injury (LTPAQ-SCI. In the database search we found studies also focusing on the objective measurements of physical activity of wheelchair users with SCI. The physical switches used by intact populations are adapted for measurements (pedometers, accelerometers, speedometers. Most recent studies utilize Accelerometer based Activity Monitors which are attached to wheel of wheelchair or body of wheelchair users (wrist, leg or chest. Conclusions: This study is essential to critically approach issues of health and active lifestyle of persons with SCI and its use for teaching of students of adapted physical activity and physiotherapy.

  11. Reproducibility of XPS analysis for film thickness of SiO{sub 2}/Si by active Shirley method

    Energy Technology Data Exchange (ETDEWEB)

    Matsumoto, Ryo, E-mail: MATSUMOTO.Ryo@nims.go.jp [National Institute of Technology, Yonago College, Tottori 683-8502 (Japan); Graduate School of Pure and Applied Science, University of Tsukuba, Tsukuba 305-8577 (Japan); National Institute for Materials Science, Tsukuba 305-0044 (Japan); Nishizawa, Yugo; Kataoka, Noriyuki; Tanaka, Hiromi [National Institute of Technology, Yonago College, Tottori 683-8502 (Japan); Yoshikawa, Hideki; Tanuma, Shigeo [National Institute for Materials Science, Tsukuba 305-0044 (Japan); Yoshihara, Kazuhiro [Scienta Omicron, Inc, Tokyo 140-0013 (Japan)

    2016-02-15

    Highlights: • We proposed a new advantage for estimation of XPS background in active Shirley method. • Active Shirley method can estimate a reproducible background without operator dependence. • Active Shirley method demonstrated that the thickness of the SiO{sub 2} film was estimated at 9.71 ± 0.14 nm from noisy Si 2p peaks in the commonly-used range. • We developed practical software including useful GUI with active Shirley method. - Abstract: The active Shirley method has been recently proposed for reproducibly estimating the background and peaks of X-ray photoelectron spectroscopy (XPS) spectra because of its automatic tuning of starting and ending points of the Shirley-type background spectra. This reproducibility is significantly affected not only by a software algorithm of the active Shirley method but also by a choice of the initial ending points or a shape of Voigt function. In this work, we provided an example of the reproducibility of XPS analysis for SiO{sub 2} film (9.2 nm thick) on Si wafer by changing the range of initial ending points or a shape of Voigt function in the active Shirley method. It demonstrated that the thickness of the SiO{sub 2} film was estimated at 9.71 ± 0.14 nm from noisy Si 2p peaks in the commonly-used range.

  12. Analysis and classification of physical and chemical methods of fuel activation

    Directory of Open Access Journals (Sweden)

    Fedorchak Viktoriya

    2015-12-01

    Full Text Available The offered article explores various research studies, developed patents in terms of physical and chemical approaches to the activation of fuel. In this regard, national and foreign researches in the field of fuels activators with different principles of action were analysed, evaluating their pros and cons. The article also intends to classify these methods and compare them regarding diverse desired results and types of fuels used. In terms of physical and chemical influences on fuels and the necessity of making constructive changes in the fuel system of internal combustion engines, an optimal approach was outlined.

  13. X-RAY FLUORESCENCE ANALYSIS OF HANFORD LOW ACTIVITY WASTE SIMULANTS METHOD DEVELOPMENT

    Energy Technology Data Exchange (ETDEWEB)

    Jurgensen, A; David Missimer, D; Ronny Rutherford, R

    2007-08-08

    The x-ray fluorescence laboratory (XRF) in the Analytical Development Directorate (ADD) of the Savannah River National Laboratory (SRNL) was requested to develop an x-ray fluorescence spectrometry method for elemental characterization of the Hanford Tank Waste Treatment and Immobilization Plant (WTP) pretreated low activity waste (LAW) stream to the LAW Vitrification Plant. The WTP is evaluating the potential for using XRF as a rapid turnaround technique to support LAW product compliance and glass former batching. The overall objective of this task was to develop an XRF analytical method that provides rapid turnaround time (<8 hours), while providing sufficient accuracy and precision to determine variations in waste.

  14. The Cost of Company Occupational Accidents: An Activity Based Analysis using the SACA Method

    DEFF Research Database (Denmark)

    Rikhardsson, Pall M.; Impgaard, Martin

    The Systematic Accident Cost Analysis (SACA) project is a research project carried out during 2001 by The Aarhus School of Business and PricewaterhouseCoopers Denmark with financial support from The Danish National Working Environment Authority. It empirically tested a method - the SACA method...... - for evaluating the visible and hidden costs of corporate occupational accidents. It also focused on whether the registration, processing and reporting of these costs could be integrated in the corporate accounting information system. The project was based on case studies in 9 Danish companies within 3 different...

  15. A Method for Structure–Activity Analysis of Quorum-Sensing Signaling Peptides from Naturally Transformable Streptococci

    Directory of Open Access Journals (Sweden)

    Tian XiaoLin

    2009-06-01

    Full Text Available Abstract Many species of streptococci secrete and use a competence-stimulating peptide (CSP to initiate quorum sensing for induction of genetic competence, bacteriocin production, and other activities. These signaling molecules are small, unmodified peptides that induce powerful strain-specific activity at nano-molar concentrations. This feature has provided an excellent opportunity to explore their structure–function relationships. However, CSP variants have also been identified in many species, and each specifically activates its cognate receptor. How such minor changes dramatically affect the specificity of these peptides remains unclear. Structure–activity analysis of these peptides may provide clues for understanding the specificity of signaling peptide–receptor interactions. Here, we use the Streptococcus mutans CSP as an example to describe methods of analyzing its structure–activity relationship. The methods described here may provide a platform for studying quorum-sensing signaling peptides of other naturally transformable streptococci.

  16. A classification and summarization method for analysis of research activities in an academic faculty

    Directory of Open Access Journals (Sweden)

    Eduardo Rocha Loures

    Full Text Available Abstract Nowadays, more and more scientific research activities are carried out in different laboratories and universities, which not only play an important role in the development of science and technology, but also show a significant inference on education. The improvement of the research capability of an academic faculty can directly impact the quality of education, bring innovations to Industrial Engineering curriculum proposals, and guarantee the subjects are up to date. The investigation of the existing issues in the current research activities is usually considered as the primary and challenging step. As the output of research activities, academic articles are often considered as a kind of evidence-based resources for the investigation. Despite some methodological efforts have been made by existing article review methods, less attention has been paid to discover the implicit academic relationships among the academic staffs and to investigate their research expertise. The objective of this study is to address this existing drawback through the proposition of an Academic Information Classification and Summarization method. A case study is carried out in the Industrial and System Engineering Graduate Program (PPGEPS, PUCPR, Brazil. The result not only highlights the advantages that can be obtained from this proposition from the education perspective related to Industrial Engineering, but also can be used as evidence to balance and compare an academic staff’s research expertise and his/her teaching disciplines.

  17. Active Speed Compensation Method of Direct Torque Control System and Stability Analysis

    Directory of Open Access Journals (Sweden)

    Rui Li

    2015-02-01

    Full Text Available By analyzing characteristics of the DTC (direct torque control system in electrical driving system, a shortcoming of the classical DTC method is to point out that it is unable to decouple the mutual interference between torque and speed, so that when a running asynchronous motor subjected to an instantaneous impact load, rotor speed and its deviation appears excessive fluctuations that can not be quickly restored to the initial set value. In this research, under conditions that without sensors for measuring load torque and rotor speed, to an electrical drive systems contains DTC devices, a novel ASCC (active speed compensation control method is proposed based on ADRC (active disturbance rejection control theory, on account of DTC model of asynchronous motor, a multiobjective observer is designed to regulate both the speed and the torque, and a proof of asymptotic stability that related this new control systems with the observer is made by theoretical deduction. Finally stimulating results show that this method can overcome the shortcomings of classical DTC system and greatly enhance the ability of the high-speed driving system to deal with unexpected impact loads.

  18. A method to quantify movement activity of groups of animals using automated image analysis

    Science.gov (United States)

    Xu, Jianyu; Yu, Haizhen; Liu, Ying

    2009-07-01

    Most physiological and environmental changes are capable of inducing variations in animal behavior. The behavioral parameters have the possibility to be measured continuously in-situ by a non-invasive and non-contact approach, and have the potential to be used in the actual productions to predict stress conditions. Most vertebrates tend to live in groups, herds, flocks, shoals, bands, packs of conspecific individuals. Under culture conditions, the livestock or fish are in groups and interact on each other, so the aggregate behavior of the group should be studied rather than that of individuals. This paper presents a method to calculate the movement speed of a group of animal in a enclosure or a tank denoted by body length speed that correspond to group activity using computer vision technique. Frame sequences captured at special time interval were subtracted in pairs after image segmentation and identification. By labeling components caused by object movement in difference frame, the projected area caused by the movement of every object in the capture interval was calculated; this projected area was divided by the projected area of every object in the later frame to get body length moving distance of each object, and further could obtain the relative body length speed. The average speed of all object can well respond to the activity of the group. The group activity of a tilapia (Oreochromis niloticus) school to high (2.65 mg/L) levels of unionized ammonia (UIA) concentration were quantified based on these methods. High UIA level condition elicited a marked increase in school activity at the first hour (P<0.05) exhibiting an avoidance reaction (trying to flee from high UIA condition), and then decreased gradually.

  19. Analysis Of The Method Of Predictive Control Applicable To Active Magnetic Suspension Systems Of Aircraft Engines

    Directory of Open Access Journals (Sweden)

    Kurnyta-Mazurek Paulina

    2015-12-01

    Full Text Available Conventional controllers are usually synthesized on the basis of already known parameters associated with the model developed for the object to be controlled. However, sometimes it proves extremely difficult or even infeasible to find out these parameters, in particular when they subject to changes during the exploitation lifetime. If so, much more sophisticated control methods have to be applied, e.g. the method of predictive control. Thus, the paper deals with application of the predictive control approach to follow-up tracking of an active magnetic suspension where the mathematical and simulation models for such a control system are disclosed with preliminary results from simulation investigations of the control system in question.

  20. Development of distinction method of production area of ginsengs by using a neutron activation analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Youngjin; Chung, Yongsam; Sim, Chulmuu; Sun, Gwangmin; Lee, Yuna; Yoo, Sangho

    2011-01-15

    During the last 2 years of the project, we have tried to develop the technology to make a distinction of the production areas for Korean ginsengs cultivated in the various provinces in Korea and foreign countries. It will contribute to secure the health food safety for public and stability of its market. In this year, we collected ginseng samples cultivated in the northeastern province in Chinese mainland such as Liaoning province, Jilin province and Baekdu mountain within Jilin province. 10 ginseng samples were collected at each province. The elemental concentrations in the ginseng were analyzed by using a neutron activation analysis technique at the HANARO research reactor. The distinction of production area was made by using a statistical software. As a result, the Chinese Korean ginsengs were certainly differentiated from those cultivated in the famous province in Korea though there was a limitation that the number of our sample we analyzed is very small.

  1. Thick activation detectors for neutron spectrometry using different unfolding methods: sensitivity analysis and dose calculation

    Energy Technology Data Exchange (ETDEWEB)

    Medkour Ishak-Boushaki, Ghania, E-mail: gmedkour@yahoo.com [Laboratoire SNIRM-Faculte de Physique, Universite des Sciences et de la Technologie Houari Boumediene, BP 32 El-Alia BabEzzouar, Algiers (Algeria); Boukeffoussa, Khelifa [Laboratoire SNIRM-Faculte de Physique, Universite des Sciences et de la Technologie Houari Boumediene, BP 32 El-Alia BabEzzouar, Algiers (Algeria); Idiri, Zahir [Centre de Recherche Nucleaire d' Alger, 02 Boulevard Frantz-Fanon, BP 399, Algiers (Algeria); Allab, Malika [Laboratoire SNIRM-Faculte de Physique, Universite des Sciences et de la Technologie Houari Boumediene, BP 32 El-Alia BabEzzouar, Algiers (Algeria)

    2012-03-15

    This paper discusses the use of threshold detectors of extended sizes for low intensity neutron fields' characterization. The detectors were tested by the measurement of the neutron spectrum of an {sup 241}Am-Be source. Integral quantities characterizing the neutron field, required for radiological protection, have been derived by unfolding the measured data. A good agreement is achieved between the obtained results and those deduced using Bonner spheres. In addition, a sensitivity analysis of the results to the deconvolution procedure is given. - Highlights: Black-Right-Pointing-Pointer Low intensity neutron fields' characterization using thick threshold detectors. Black-Right-Pointing-Pointer Low activity {sup 241}Am-Be neutron source spectrum measurement. Black-Right-Pointing-Pointer Integral quantities required for radiological protection have been derived. Black-Right-Pointing-Pointer The results are in good agreement with those deduced using Bonner spheres. Black-Right-Pointing-Pointer The results are not very sensitive to the chosen deconvolution procedure.

  2. Associations between diet and disease activity in ulcerative colitis patients using a novel method of data analysis

    Directory of Open Access Journals (Sweden)

    Curno Richard

    2005-02-01

    Full Text Available Abstract Background The relapsing nature and varying geographical prevalence of ulcerative colitis (UC implicates environmental factors such as diet in its aetiology. Methods In order to determine which foods might be related to disease activity in UC a new method of dietary analysis was developed and applied. Eighty-one UC patients were recruited at all stages of the disease process. Following completion of a 7 d diet diary, clinical assessment including a sigmoidoscopic examination (scale 0 (normal mucosa to 6 (very active disease was conducted. Food weights for each person were adjusted (divided by the person's calorific intake for the week. Each food consumed was given a food sigmoidoscopy score (FSS calculated by summing the products of the (adjusted weight of food consumed and sigmoidoscopy score for each patient and occurrence of food and dividing by the total (adjusted weight of the food consumed by all 81 patients. Thus, foods eaten in large quantities by patients with very active disease have high FSSs and vice versa. Foods consumed by Results High FSS foods were characterized by high levels of the anti-thiamin additive sulfite (Mann-Whitney, p Conclusions The dietary analysis method described provides a new tool for establishing relationships between diet and disease and indicates a potentially therapeutic diet for UC.

  3. ANALYSIS OF MULTISCALE METHODS

    Institute of Scientific and Technical Information of China (English)

    Wei-nan E; Ping-bing Ming

    2004-01-01

    The heterogeneous multiscale method gives a general framework for the analysis of multiscale methods. In this paper, we demonstrate this by applying this framework to two canonical problems: The elliptic problem with multiscale coefficients and the quasicontinuum method.

  4. Comparative analysis of dose rates in bricks determined by neutron activation analysis, alpha counting and X-ray fluorescence analysis for the thermoluminescence fine grain dating method

    Science.gov (United States)

    Bártová, H.; Kučera, J.; Musílek, L.; Trojek, T.

    2014-11-01

    In order to evaluate the age from the equivalent dose and to obtain an optimized and efficient procedure for thermoluminescence (TL) dating, it is necessary to obtain the values of both the internal and the external dose rates from dated samples and from their environment. The measurements described and compared in this paper refer to bricks from historic buildings and a fine-grain dating method. The external doses are therefore negligible, if the samples are taken from a sufficient depth in the wall. However, both the alpha dose rate and the beta and gamma dose rates must be taken into account in the internal dose. The internal dose rate to fine-grain samples is caused by the concentrations of natural radionuclides 238U, 235U, 232Th and members of their decay chains, and by 40K concentrations. Various methods can be used for determining trace concentrations of these natural radionuclides and their contributions to the dose rate. The dose rate fraction from 238U and 232Th can be calculated, e.g., from the alpha count rate, or from the concentrations of 238U and 232Th, measured by neutron activation analysis (NAA). The dose rate fraction from 40K can be calculated from the concentration of potassium measured, e.g., by X-ray fluorescence analysis (XRF) or by NAA. Alpha counting and XRF are relatively simple and are accessible for an ordinary laboratory. NAA can be considered as a more accurate method, but it is more demanding regarding time and costs, since it needs a nuclear reactor as a neutron source. A comparison of these methods allows us to decide whether the time- and cost-saving simpler techniques introduce uncertainty that is still acceptable.

  5. Bacterial community analysis of activated sludge: an evaluation of four commonly used DNA extraction methods

    NARCIS (Netherlands)

    Vanysacker, L.; Declerck, S.A.J.; Hellemans, B.; De Meester, L.; Vankelecom, I.; Declerck, P.

    2010-01-01

    The effectiveness of three commercially available direct DNA isolation kits (Mobio, Fast, Qiagen) and one published direct DNA extraction protocol (Bead) for extracting bacterial DNA from different types of activated sludge was investigated and mutually compared. The DNA quantity and purity were

  6. Bacterial community analysis of activated sludge: an evaluation of four commonly used DNA extraction methods

    NARCIS (Netherlands)

    Vanysacker, L.; Declerck, S.A.J.; Hellemans, B.; De Meester, L.; Vankelecom, I.; Declerck, P.

    2010-01-01

    The effectiveness of three commercially available direct DNA isolation kits (Mobio, Fast, Qiagen) and one published direct DNA extraction protocol (Bead) for extracting bacterial DNA from different types of activated sludge was investigated and mutually compared. The DNA quantity and purity were det

  7. METHODICAL APPROACHES TO THE ANALYSIS OF THE RESULTS OF RESEARCH ACTIVITIES

    Directory of Open Access Journals (Sweden)

    S. A. Trushchelev

    2010-01-01

    Full Text Available The value of scientific medical information and its impact indicators (researcher’s publishing activity, citation, impact factor, Hirsch index, etc is considered. Sources of relevant indicators are specified. Data on scientometric indicators of Russian and international scientific cardiology journals are presented.

  8. STRATEGIC PLANNING AT THE ENTERPRISE: APPLICATION OF A METHOD OF THE ANALYSIS OF HIERARCHIES FOR THE STRATEGIC ACTIVITY MONITORING

    Directory of Open Access Journals (Sweden)

    Ilya V. Samarin

    2014-01-01

    Full Text Available The technique of application of a method of the analysis of hierarchiesfor the solution of problems of monitoring of activity of the enterprise onadvance to a strategic objective in the course of implementation of thecurrent medium-term plan is presented. Problems of an assessment of astate and situation forecasting to the termination of the current planningperiod are considered. The matrix method which is the return method ofthe analysis of hierarchies, allowing to estimate and predict a situationwith implementation of the plan in all structures of the enterprise andrealizing procedure of strategic monitoring at the enterprise is developed. Statistical and analytical methods of the solution of a problemof forecasting are presented. For the solution of a task the statisticalmethod developed algorithm of the numerical solution of a task and itsflowchart is submitted. An algorithm for solving the problem of determination of the integral strategic risk the implementation of the set ofevents. Shows an example of solving the problem of determination ofthe degree of achievement of the intermediate objectives for the knownvalues of the degree of implementation of all stipulated by a plan ofactions (works for the six-level hierarchical scheme.

  9. Optimization of crude enzyme preparation methods for analysis of glutamine synthetase activity in phytoplankton and field samples

    Institute of Scientific and Technical Information of China (English)

    WANG Yujue; WANG Dazhi; HONG Huasheng

    2009-01-01

    Glutamine synthetase (GS) is an important enzyme involved in nitrogen assimilation and metabolism in marine phytoplankton. However, little work has been done in situ due to the limitation of crude enzyme preparation methods. In this study, three enzyme preparation methods, high-speed centrifugation (HC, <10 000 g), ultracentrifugation (UC, 70 000 g), and ultrafiltration (UF) with 100 kμ, molecular weight cutoff, were compared using two diatom species (Asterionellopsis glacialis and Thalassiosira weissflogii), and two dinoflagellate species (Alexandrium catenella and Prorocentrum donghaiense) as experimental materials together with field samples collected from Xiamen Harbor, China. The results showed that HC is the best method to prepare crude enzymes for glutamine synthetase activity (GSA) in diatom species and diatom-dominant samples, while UF is the best method to extract GS from dinoflagellate species and dinoflagellate-dominant samples. For the HC method, the optimal centrifugal speed and time were 10 000 g and 35 min, respectively, and under these conditions, the highest GSA was obtained in all samples. This study indicates that both methods (HC and UF) overcome the limitation of centrifugal speed and could be applied to in situ GSA analysis, especially at sea.

  10. Performance analysis of a modified moving shadow elimination method developed for indoor scene activity tracking

    Science.gov (United States)

    Mitra, Bhargav Kumar; Fiaz, Muhammad Kamran; Kypraios, Ioannis; Birch, Philip; Young, Rupert; Chatwin, Chris

    2008-10-01

    Moving shadow detection is an important step in automated robust surveillance systems in which a dynamic object is to be segmented and tracked. Rejection of the shadow region significantly reduces the erroneous tracking of non-target objects within the scene. A method to eliminate such shadows in indoor video sequences has been developed by the authors. The objective has been met through the use of a pixel-wise shadow search process that utilizes a computational model in the RGB colour space to demarcate the moving shadow regions from the background scene and the foreground objects. However, it has been observed that the robustness and efficiency of the method can be significantly enhanced through the deployment of a binary-mask based shadow search process. This, in turn, calls for the use of a prior foreground object segmentation technique. The authors have also automated a standard foreground object segmentation technique through the deployment of some popular statistical outlier-detection based strategies. The paper analyses the performance i.e. the effectiveness as a shadow detector, discrimination potential, and the processing time of the modified moving shadow elimination method on the basis of some standard evaluation metrics.

  11. Determination of antioxidant activity in herbal ingredients for foods using new methods of chemical analysis

    Directory of Open Access Journals (Sweden)

    Katalina Muñoz

    2012-06-01

    Full Text Available A new procedure has been used to separate and quantify the free radical-scavenging activity of individual compounds 18 samples of Thymus vulgaris and 12 samples of Rosmarinus officinalis (both used as natural food preservatives, based on the combination of HPTLC (High Performance Thin Layer Chromatography and postchromatographic DPPH● radical derivatization. The compounds thymol and rosmarinic acid in T. vulgaris and R. officinalis, respectively, were identified by comparisons of their Rf values and UV spectra to standards analyzed under identical analytical conditions, while the quantitative data were calculated from their calibration curves. We found that not only that the biomass yield but also the metabolite content in herbs, depend on the ecotype (genetics and on the agro ecological conditions. The effect of the ambient on the metabolite content is extremely significant and also on their antioxidant activity (One-way ANOVA with Newman-Keuls Multiple Comparison post test was performed using GraphPad Prism version 4.00 for Windows, GraphPad Software. This work pretends to demonstrate the great importance of using new technologies for the selection of the best materials used as natural food preservatives.

  12. Active Mg Estimation Using Thermal Analysis: A Rapid Method to Control Nodularity in Ductile Cast Iron Production

    Science.gov (United States)

    Suárez, Ramon; Sertucha, Jon; Larrañaga, Pello; Lacaze, Jacques

    2016-10-01

    Appropriate nodularity in ductile iron castings is strongly associated with the presence of high enough not combined Mg dissolved in the melt to cast. However, the residual Mg which is commonly measured for production control accounts for both dissolved Mg and Mg combined as oxides and sulfides. To account for the uncertainties associated with such a control, it is quite usual to over treat the melt with the risk of porosity appearance. A new methodology based on thermal analysis has been developed in the present work so as to estimate the amount of free Mg dissolved in the melt ready for pouring. A combination of Te mixture and a new "reactive mixture" composed of sulfur plus a commercial inoculant has been prepared for this purpose. This reactive mixture is able to transform the magnesium remaining dissolved in the melt to combined forms of this element. Experiments performed both during start of production (when Mg overtreatment is usual) and during normal mass production indicate that important variations of free Mg occur without relevant changes in residual Mg content as determined by spectrometry. The method developed in the present work has shown to be highly effective to detect those melt batches where active Mg content is not high enough for guaranteeing a correct nodularity of castings. Selection of proper active Mg thresholds and a correct inoculation process are critical to avoid "false"-negative results when using this new method.

  13. Quantitative Laser Biospeckle Method for the Evaluation of the Activity of Trypanosoma cruzi Using VDRL Plates and Digital Analysis

    Science.gov (United States)

    Grassi, Hilda Cristina; García, Lisbette C.; Lobo-Sulbarán, María Lorena; Velásquez, Ana; Andrades-Grassi, Francisco A.; Cabrera, Humberto; Andrades-Grassi, Jesús E.; Andrades, Efrén D. J.

    2016-01-01

    In this paper we report a quantitative laser Biospeckle method using VDRL plates to monitor the activity of Trypanosoma cruzi and the calibration conditions including three image processing algorithms and three programs (ImageJ and two programs designed in this work). Benznidazole was used as a test drug. Variable volume (constant density) and variable density (constant volume) were used for the quantitative evaluation of parasite activity in calibrated wells of the VDRL plate. The desiccation process within the well was monitored as a function of volume and of the activity of the Biospeckle pattern of the parasites as well as the quantitative effect of the surface parasite quantity (proportion of the object’s plane). A statistical analysis was performed with ANOVA, Tukey post hoc and Descriptive Statistics using R and R Commander. Conditions of volume (100μl) and parasite density (2-4x104 parasites/well, in exponential growth phase), assay time (up to 204min), frame number (11 frames), algorithm and program (RCommander/SAGA) for image processing were selected to test the effect of variable concentrations of benznidazole (0.0195 to 20μg/mL / 0.075 to 76.8μM) at various times (1, 61, 128 and 204min) on the activity of the Biospeckle pattern. The flat wells of the VDRL plate were found to be suitable for the quantitative calibration of the activity of Trypanosoma cruzi using the appropriate algorithm and program. Under these conditions, benznidazole produces at 1min an instantaneous effect on the activity of the Biospeckle pattern of T. cruzi, which remains with a similar profile up to 1 hour. A second effect which is dependent on concentrations above 1.25μg/mL and is statistically different from the effect at lower concentrations causes a decrease in the activity of the Biospeckle pattern. This effect is better detected after 1 hour of drug action. This behavior may be explained by an instantaneous effect on a membrane protein of Trypanosoma cruzi that could

  14. Quantitative Laser Biospeckle Method for the Evaluation of the Activity of Trypanosoma cruzi Using VDRL Plates and Digital Analysis.

    Science.gov (United States)

    Grassi, Hilda Cristina; García, Lisbette C; Lobo-Sulbarán, María Lorena; Velásquez, Ana; Andrades-Grassi, Francisco A; Cabrera, Humberto; Andrades-Grassi, Jesús E; Andrades, Efrén D J

    2016-12-01

    In this paper we report a quantitative laser Biospeckle method using VDRL plates to monitor the activity of Trypanosoma cruzi and the calibration conditions including three image processing algorithms and three programs (ImageJ and two programs designed in this work). Benznidazole was used as a test drug. Variable volume (constant density) and variable density (constant volume) were used for the quantitative evaluation of parasite activity in calibrated wells of the VDRL plate. The desiccation process within the well was monitored as a function of volume and of the activity of the Biospeckle pattern of the parasites as well as the quantitative effect of the surface parasite quantity (proportion of the object's plane). A statistical analysis was performed with ANOVA, Tukey post hoc and Descriptive Statistics using R and R Commander. Conditions of volume (100μl) and parasite density (2-4x104 parasites/well, in exponential growth phase), assay time (up to 204min), frame number (11 frames), algorithm and program (RCommander/SAGA) for image processing were selected to test the effect of variable concentrations of benznidazole (0.0195 to 20μg/mL / 0.075 to 76.8μM) at various times (1, 61, 128 and 204min) on the activity of the Biospeckle pattern. The flat wells of the VDRL plate were found to be suitable for the quantitative calibration of the activity of Trypanosoma cruzi using the appropriate algorithm and program. Under these conditions, benznidazole produces at 1min an instantaneous effect on the activity of the Biospeckle pattern of T. cruzi, which remains with a similar profile up to 1 hour. A second effect which is dependent on concentrations above 1.25μg/mL and is statistically different from the effect at lower concentrations causes a decrease in the activity of the Biospeckle pattern. This effect is better detected after 1 hour of drug action. This behavior may be explained by an instantaneous effect on a membrane protein of Trypanosoma cruzi that could

  15. Multielement analysis of human hair and kidney stones by instrumental neutron activation analysis with the k{sub 0}-standardization method

    Energy Technology Data Exchange (ETDEWEB)

    Abugassa, I.; Sarmani, S.B. [Department of Nuclear Science, Universiti Kebangsaan Malaysia, Bangi, Selangor (Malaysia); Samat, S.B. [Department of Physics, Universiti Kebangsaan Malaysia, Bangi, Selangor (Malaysia)

    1999-06-01

    This paper focuses on the evaluation of the k{sub 0} method of instrumental neutron activation analysis in biological materials. The method has been applied in multielement analysis of human hair standard reference materials from IAEA, No. 085, No. 086 and from NIES (National Institute for Environmental Sciences) No. 5. Hair samples from people resident in different parts of Malaysia, in addition to a sample from Japan, were analyzed. In addition, human kidney stones from members of the Malaysian population have been analyzed for minor and trace elements. More than 25 elements have been determined. The samples were irradiated in the rotary rack (Lazy Susan) at the TRIGA Mark II reactor of the Malaysian Institute for Nuclear Technology and Research (MINT). The accuracy of the method was ascertained by analysis of other reference materials, including 1573 tomato leaves and 1572 citrus leaves. In this method the deviation of the 1/E{sup 1+{alpha}} epithermal neutron flux distribution from the 1/E law (P/T ratio) for true coincidence effects of the {gamma}-ray cascade and the HPGe detector efficiency were determined and corrected for.

  16. Methods of Multivariate Analysis

    CERN Document Server

    Rencher, Alvin C

    2012-01-01

    Praise for the Second Edition "This book is a systematic, well-written, well-organized text on multivariate analysis packed with intuition and insight . . . There is much practical wisdom in this book that is hard to find elsewhere."-IIE Transactions Filled with new and timely content, Methods of Multivariate Analysis, Third Edition provides examples and exercises based on more than sixty real data sets from a wide variety of scientific fields. It takes a "methods" approach to the subject, placing an emphasis on how students and practitioners can employ multivariate analysis in real-life sit

  17. Analysis of two precipitation methods on the yield, structural features and activity of sulfated polysaccharides from Gracilaria cornea (Rhodophyta

    Directory of Open Access Journals (Sweden)

    Ricardo Basto Souza

    2015-03-01

    Full Text Available The global demand for natural products from seaweeds has increased worldwide; however, no description of the use of isoamly alcohol (IAA for obtaining of sulfated polysaccharides (SPs has been reported. We investigated the efficiency of two precipitation methods (M in obtaining SPs from the red seaweed Gracilaria cornea. SPs enzymatically isolated were concentrated with cetylpyridinium chloride (M I or IAA (M II and extracts were examined with regard to their yield, structural features and in vitro effects on the activated partial thromboplastin time (APTT using normal human plasma and standard heparin (193 IU mg-1. Yield difference reached 12.99%. Quantitative determination of sulfate was similar between the two methods (̴ 26%, but extracts revealed different pattern on charge density by agarose gel electrophoresis. Whereas both extracts revealed as agarocolloids, alternative M II was also efficient for lipids, proteins and nucleic acids according to the infrared analysis. Extracts had virtually no effect on APPT (1.95 and 2 IU mg-1 for M I and M II, respectively. The results revealed IAA as an alternative solvent for obtaining SPs from the red seaweed G. cornea, depending on the industry’ usage criterion.

  18. Active Learning Methods

    Science.gov (United States)

    Zayapragassarazan, Z.; Kumar, Santosh

    2012-01-01

    Present generation students are primarily active learners with varied learning experiences and lecture courses may not suit all their learning needs. Effective learning involves providing students with a sense of progress and control over their own learning. This requires creating a situation where learners have a chance to try out or test their…

  19. An Analysis of the Romanian General Accounting Plan. Opportunities for Adaptation to the Activity-Based Costing (ABC Method

    Directory of Open Access Journals (Sweden)

    Irina-Alina Preda

    2008-11-01

    Full Text Available In this article, we analyze the causes that have led to the improvement of the Romanian general accounting plan according to the Activity- Based Costing (ABC method. We explain the advantages presented by the dissociated organization of management accounting, in contrast with the tabular- statistical form. The article also describes the methodological steps to be taken in the process of recording book entries, according to the Activity-Based Costing (ABC method in Romania.

  20. Analysis of numerical methods

    CERN Document Server

    Isaacson, Eugene

    1994-01-01

    This excellent text for advanced undergraduates and graduate students covers norms, numerical solution of linear systems and matrix factoring, iterative solutions of nonlinear equations, eigenvalues and eigenvectors, polynomial approximation, and other topics. It offers a careful analysis and stresses techniques for developing new methods, plus many examples and problems. 1966 edition.

  1. Methods for testing antioxidant activity.

    Science.gov (United States)

    Antolovich, Michael; Prenzler, Paul D; Patsalides, Emilios; McDonald, Suzanne; Robards, Kevin

    2002-01-01

    Antioxidant activity has been assessed in many ways. The limitation of many newer methods is the frequent lack of an actual substrate in the procedure. The combination of all approaches with the many test methods available explains the large variety of ways in which results of antioxidant testing are reported. The measurement of antioxidant activities, especially of antioxidants that are mixtures, multifunctional or are acting in complex multiphase systems, cannot be evaluated satisfactorily by a simple antioxidant test without due regard to the many variables influencing the results. Several test procedures may be required to evaluate such antioxidant activities. A general method of reporting antioxidant activity independent of the test procedure is proposed.

  2. Non-destructive elemental analysis of large meteorite samples by prompt gamma-ray neutron activation analysis with the internal mono-standard method.

    Science.gov (United States)

    Latif, Sk A; Oura, Y; Ebihara, M; Nakahara, H

    2013-11-01

    Prompt gamma-ray neutron activation analysis (PGNAA) using the internal mono-standard method was tested for its applicability to analyzing large solid samples including irregularly shaped meteorite samples. For evaluating the accuracy and precision of the method, large quantities of the Geological Survey of Japan standardized rock powders (JB-1a, JG-1a, and JP-1) were analyzed and 12 elements (B, Na, Mg, Al, Cl, K, Ca, Ti, Mn, Fe, Sm, and Gd) were determined by using Si as an internal standard element. Analytical results were mostly in agreement with literature values within 10 %. The precision of the method was also shown to be within 10 % (1σ) for most of these elements. The analytical procedure was then applied to four stony meteorites (Allende, Kimble County, Leedey, Lake Labyrinth) and four iron meteorites (Canyon Diablo, Toluca (Mexico), Toluca (Xiquipilco), Squaw Creek) consisting of large chunks or single slabs. For stony meteorites, major elements (Mg, Al, Si, S, Ca, and Ni), minor elements (Na and Mn) and trace element (B, Cl, K, Ti, Co, and Sm) were determined with adequate accuracy. For iron meteorites, results for the Co and Ni mass fractions determined are all consistent with corresponding literature values. After the analysis, it was confirmed that the residual radioactivity remaining in the sample after PGNAA was very low and decreased down to the background level. This study shows that PGNAA with the internal mono-standard method is highly practical for determining the elemental composition of large, irregularly shaped solid samples including meteorites.

  3. Methods for RNA Analysis

    DEFF Research Database (Denmark)

    Olivarius, Signe

    of the transcriptome, 5’ end capture of RNA is combined with next-generation sequencing for high-throughput quantitative assessment of transcription start sites by two different methods. The methods presented here allow for functional investigation of coding as well as noncoding RNA and contribute to future......While increasing evidence appoints diverse types of RNA as key players in the regulatory networks underlying cellular differentiation and metabolism, the potential functions of thousands of conserved RNA structures encoded in mammalian genomes remain to be determined. Since the functions of most...... RNAs rely on interactions with proteins, the establishment of protein-binding profiles is essential for the characterization of RNAs. Aiming to facilitate RNA analysis, this thesis introduces proteomics- as well as transcriptomics-based methods for the functional characterization of RNA. First, RNA...

  4. Activity based costing (ABC Method

    Directory of Open Access Journals (Sweden)

    Prof. Ph.D. Saveta Tudorache

    2008-05-01

    Full Text Available In the present paper the need and advantages are presented of using the Activity BasedCosting method, need arising from the need of solving the information pertinence issue. This issue has occurreddue to the limitation of classic methods in this field, limitation also reflected by the disadvantages ofsuch classic methods in establishing complete costs.

  5. Studies on the method for determination of fluoride concentration in rat hard tissues by neutron activation analysis using sup 20 F

    Energy Technology Data Exchange (ETDEWEB)

    Nakakura, Tadao (Nippon Dental Univ., Tokyo (Japan))

    1991-04-01

    Neutron activation analysis method (non disruptive analysis, short time period measurement) has been recognized as a high precision analysis of fluoride concentration in hard tissue. Heat neutron irradiation analysis using instrumental neutron activation analysis (INAA) method was used to investigate {sup 20}F concentration. Results were as follows. F concentration in a dried material of hard tissue using INAA method can be fixed by measuring the {sup 20}F's energy peak for 10 seconds after neutron irradiation under 1 x 10 n/cm{sup 2}center dots for 10 seconds. Non responding time that is caused by short half reduction time of {sup 20}F can be recovered enough by a revise calculation. Reproducibility of measured fluoride concentration using INAA method was well stabilized. Rat hard tissue which takes no fluoride can be determined fluoride concentration without sodium restriction. Femur fluoride concentrations using INAA method had significant correlation with conventional microdiffusion analysis method (r=0.997, regression line: Y=1.13X + 2.98). Increase of fluoride density in dentine of rat molars under growing period according to fluoride intake was 1/3 of femurs and mandibles. (author).

  6. Expression analysis of polyphenol oxidase isozymes by active staining method and tissue browning of head lettuce (Lactuca sativa L.).

    Science.gov (United States)

    Noda, Takahiro; Iimure, Kazuhiko; Okamoto, Shunsuke; Saito, Akira

    2017-08-01

    Browning of plant tissue is generally considered attributable to enzymatic oxidation by polyphenol oxidase (PPO). Electrophoresis followed by activity staining has been used as an effective procedure to visually detect and isolate isozymes; however, it has not been applied for examination of various PPO isozymes in lettuce. Our study demonstrated that different lettuce PPO isozymes could be detected at different pH in active staining, and multiple isozymes were detected only under alkaline conditions. As a result, we concluded that activity staining with approximately pH 8 enabled to detect various PPO isozymes in lettuce. By expression analysis of the PPO isozymes after wounding, PPO isozymes that correlated with time-course of tissue browning were detected. The wound-induced PPO may play a key role in enzymatic browning.

  7. Effects of different methods of DNA extraction for activated sludge on the subsequent analysis of bacterial community profiles.

    Science.gov (United States)

    Sun, Lianpeng; Ouyang, Xiong; Tang, Yueheng; Yang, Ying; Luo, Ying

    2012-02-01

    The effect of different DNA extraction protocols on activated sludge DNA yield and bacterial community composition was evaluated by temperature gradient gel electrophoresis (TGGE). Nine different procedures to extract DNA were compared-sonication (30s), sonication (40s), sonication (50s), freezing-thawing, bead milling, sodium dodecyl sulfate (SDS)-lysozyme, SDS-proteinase K, SDS-lysozyme-proteinase, and a commercial extraction kit. It was found that the TGGE profiles and the DNA band numbers made significant differences via various extraction methods. The yield and purity of DNA extracted by sonication and other physical methods were not satisfactory, while the DNA purity extracted by SDS and other chemical-biological methods were better. Crude DNA extracts isolated by sonication and other physical methods passed the polymerase chain reaction, despite the absence of purification and acquired affluent DNA bands in TGGE. The affluence of bands in TGGE was not consistent with the yield and purification of DNA, but was correlative with extraction protocols. To analyze the activated sludge bacterial community by TGGE fingerprint, it is necessary to make a synthesis of the TGGE fingerprint profiles of chemical and physical DNA extraction methods to overcome the representative bias.

  8. The development and application of k -standardization method of neutron activation analysis at Es-Salam research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Alghem, L. [Departement d' Analyse par Activation Neutronique, CRNB, BP 180, Ain Oussera 17200, W Djelfa (Algeria)]. E-mail: lylia_25@hotmail.com; Ramdhane, M. [Departement de physique, Universite Mentouri de Constantine (Algeria); Khaled, S. [Departement d' Analyse par Activation Neutronique, CRNB, BP 180, Ain Oussera 17200, W Djelfa (Algeria); Akhal, T. [Departement d' Analyse par Activation Neutronique, CRNB, BP 180, Ain Oussera 17200, W Djelfa (Algeria)

    2006-01-01

    In recent years the k -NAA method has been applied and developed at the 15 MW Es-Salam research reactor, which includes: (1) the detection efficiency calibration of {gamma}-spectrometer used in k -NAA (2) the determination of reactor neutron spectrum parameters such as {alpha} and f factors in the irradiation channel, and (3) the validation of the developed k -NAA procedure by analysing SRM, namely AIEA-Soil7 and CRM, namely IGGE-GSV4. The analysis results obtained by k -NAA with 27 elements of Soil-7 standard and 14 elements of GSV-4 standard were compared with certified values. The analysis results showed that the deviations between experimental and certified values were mostly less than 10%. The k -NAA procedure established at Es-Salam research reactor has been regarded as a reliable standardization method of NAA and as available for practical applications.

  9. Physical activity and sedentary lifestyle in children as time-limited functions: usefulness of the principal component analysis method.

    Science.gov (United States)

    Guinhouya, Comlavi B; Soubrier, Stephane; Vilhelm, Christian; Ravaux, Pierre; Lemdani, Mohamed; Durocher, Alain; Hubert, Hervé

    2007-08-01

    This study was designed to examine the hourly variation in and the interplay between physical activity and sedentary behavior (SB) in order to highlight key time periods for physical activity interventions for children. Data for physical activity and SB obtained with ActiGraph in 56 boys and 47 girls aged from 8 to 11 years. These data were divided into sixty minute-time samples for moderate-to-vigorous physical activity (MVPA) and SB, and analyzed using a principal component analysis (PCA) and correlation statistics. The PCA provides 10 factors which account for 80.4% of the inertia. Only two of these factors did not display competition between MVPA and SB. Contrary to some reports, a coefficient of correlation of -.68 (p < 10(-4)) was found between daily time spent at MVPA and SB. Some salient traits of children's behaviors were shown through PCA. The results suggested that efficacy of interventions targeting the morning hours (07:00 AM-11:59 AM) and the afternoon period (02:00 PM-05:59 PM) warrants attention.

  10. Design and Analysis of a Silicon-Based Pattern Reconfigurable Antenna Employing an Active Element Pattern Method

    Directory of Open Access Journals (Sweden)

    Ke Han

    2017-01-01

    Full Text Available In this paper, a silicon-based radio frequency micro-electromechanical systems (RF MEMS pattern reconfigurable antenna for a Ka-band application was designed, analyzed, fabricated, and measured. The proposed antenna can steer the beam among three radiating patterns (with main lobe directions of −20°, 0°, and +20° approximately at 35 GHz by switching RF MEMS operating modes. The antenna has a low profile with a small size of 3.7 mm × 4.4 mm × 0.4 mm, and consists of one driven patch, four parasitic patches, two assistant patches, and two RF MEMS switches. The active element pattern method integrated with signal flow diagram was employed to analyze the performances of the proposed antenna. Comparing the measured results with analytical and simulated ones, good agreements are obtained.

  11. Activity – based costing method

    Directory of Open Access Journals (Sweden)

    Èuchranová Katarína

    2001-06-01

    Full Text Available Activity based costing is a method of identifying and tracking the operating costs directly associated with processing items. It is the practice of focusing on some unit of output, such as a purchase order or an assembled automobile and attempting to determine its total as precisely as poccible based on the fixed and variable costs of the inputs.You use ABC to identify, quantify and analyze the various cost drivers (such as labor, materials, administrative overhead, rework. and to determine which ones are candidates for reduction.A processes any activity that accepts inputs, adds value to these inputs for customers and produces outputs for these customers. The customer may be either internal or external to the organization. Every activity within an organization comprimes one or more processes. Inputs, controls and resources are all supplied to the process.A process owner is the person responsible for performing and or controlling the activity.The direction of cost through their contact to partial activity and processes is a new modern theme today. Beginning of this method is connected with very important changes in the firm processes.ABC method is a instrument , that bring a competitive advantages for the firm.

  12. A method for predicting target drug efficiency in cancer based on the analysis of signaling pathway activation.

    Science.gov (United States)

    Artemov, Artem; Aliper, Alexander; Korzinkin, Michael; Lezhnina, Ksenia; Jellen, Leslie; Zhukov, Nikolay; Roumiantsev, Sergey; Gaifullin, Nurshat; Zhavoronkov, Alex; Borisov, Nicolas; Buzdin, Anton

    2015-10-06

    A new generation of anticancer therapeutics called target drugs has quickly developed in the 21st century. These drugs are tailored to inhibit cancer cell growth, proliferation, and viability by specific interactions with one or a few target proteins. However, despite formally known molecular targets for every "target" drug, patient response to treatment remains largely individual and unpredictable. Choosing the most effective personalized treatment remains a major challenge in oncology and is still largely trial and error. Here we present a novel approach for predicting target drug efficacy based on the gene expression signature of the individual tumor sample(s). The enclosed bioinformatic algorithm detects activation of intracellular regulatory pathways in the tumor in comparison to the corresponding normal tissues. According to the nature of the molecular targets of a drug, it predicts whether the drug can prevent cancer growth and survival in each individual case by blocking the abnormally activated tumor-promoting pathways or by reinforcing internal tumor suppressor cascades. To validate the method, we compared the distribution of predicted drug efficacy scores for five drugs (Sorafenib, Bevacizumab, Cetuximab, Sorafenib, Imatinib, Sunitinib) and seven cancer types (Clear Cell Renal Cell Carcinoma, Colon cancer, Lung adenocarcinoma, non-Hodgkin Lymphoma, Thyroid cancer and Sarcoma) with the available clinical trials data for the respective cancer types and drugs. The percent of responders to a drug treatment correlated significantly (Pearson's correlation 0.77 p = 0.023) with the percent of tumors showing high drug scores calculated with the current algorithm.

  13. Quantitative structure–activity relationship study of P2X7 receptor inhibitors using combination of principal component analysis and artificial intelligence methods

    Science.gov (United States)

    Ahmadi, Mehdi; Shahlaei, Mohsen

    2015-01-01

    P2X7 antagonist activity for a set of 49 molecules of the P2X7 receptor antagonists, derivatives of purine, was modeled with the aid of chemometric and artificial intelligence techniques. The activity of these compounds was estimated by means of combination of principal component analysis (PCA), as a well-known data reduction method, genetic algorithm (GA), as a variable selection technique, and artificial neural network (ANN), as a non-linear modeling method. First, a linear regression, combined with PCA, (principal component regression) was operated to model the structure–activity relationships, and afterwards a combination of PCA and ANN algorithm was employed to accurately predict the biological activity of the P2X7 antagonist. PCA preserves as much of the information as possible contained in the original data set. Seven most important PC's to the studied activity were selected as the inputs of ANN box by an efficient variable selection method, GA. The best computational neural network model was a fully-connected, feed-forward model with 7−7−1 architecture. The developed ANN model was fully evaluated by different validation techniques, including internal and external validation, and chemical applicability domain. All validations showed that the constructed quantitative structure–activity relationship model suggested is robust and satisfactory. PMID:26600858

  14. Quantitative structure-activity relationship study of P2X7 receptor inhibitors using combination of principal component analysis and artificial intelligence methods.

    Science.gov (United States)

    Ahmadi, Mehdi; Shahlaei, Mohsen

    2015-01-01

    P2X7 antagonist activity for a set of 49 molecules of the P2X7 receptor antagonists, derivatives of purine, was modeled with the aid of chemometric and artificial intelligence techniques. The activity of these compounds was estimated by means of combination of principal component analysis (PCA), as a well-known data reduction method, genetic algorithm (GA), as a variable selection technique, and artificial neural network (ANN), as a non-linear modeling method. First, a linear regression, combined with PCA, (principal component regression) was operated to model the structure-activity relationships, and afterwards a combination of PCA and ANN algorithm was employed to accurately predict the biological activity of the P2X7 antagonist. PCA preserves as much of the information as possible contained in the original data set. Seven most important PC's to the studied activity were selected as the inputs of ANN box by an efficient variable selection method, GA. The best computational neural network model was a fully-connected, feed-forward model with 7-7-1 architecture. The developed ANN model was fully evaluated by different validation techniques, including internal and external validation, and chemical applicability domain. All validations showed that the constructed quantitative structure-activity relationship model suggested is robust and satisfactory.

  15. Methods of analysis by the U.S. Geological Survey National Water Quality Laboratory; determination of methylene blue active substances by spectrophotometry

    Science.gov (United States)

    Burkhardt, Mark R.; Cinotto, Pete J.; Frahm, Galen W.; Woodworth, Mark T.; Pritt, Jeffrey W.

    1995-01-01

    A method for the determination of methylene blue active substances in whole-water samples by liquid-liquid extraction and spectrophotometric detection is described. Sulfate and sulfonate-based surfectants are reacted with methylene blue to form a blue-colored complex. The complex is extracted into chloroform, back-washed with an acidified phosphate-based buffer solution, and measured against external standards with a probe spectrophotometer. The method detection limt for routine analysis is 0.02 milligram per liter. The precision is plus/minus 10 percent relative standard deviation. The positive bias from nitrate and chloride and U.S. Geological Survey method O-3111-83 for methylene blue active substances is minized by adding a back-washing step.

  16. Spatial and temporal analysis on the distribution of active radio-frequency identification (RFID) tracking accuracy with the Kriging method.

    Science.gov (United States)

    Liu, Xin; Shannon, Jeremy; Voun, Howard; Truijens, Martijn; Chi, Hung-Lin; Wang, Xiangyu

    2014-10-29

    Radio frequency identification (RFID) technology has already been applied in a number of areas to facilitate the tracking process. However, the insufficient tracking accuracy of RFID is one of the problems that impedes its wider application. Previous studies focus on examining the accuracy of discrete points RFID, thereby leaving the tracking accuracy of the areas between the observed points unpredictable. In this study, spatial and temporal analysis is applied to interpolate the continuous distribution of RFID tracking accuracy based on the Kriging method. An implementation trial has been conducted in the loading and docking area in front of a warehouse to validate this approach. The results show that the weak signal area can be easily identified by the approach developed in the study. The optimum distance between two RFID readers and the effect of the sudden removal of readers are also presented by analysing the spatial and temporal variation of RFID tracking accuracy. This study reveals the correlation between the testing time and the stability of RFID tracking accuracy. Experimental results show that the proposed approach can be used to assist the RFID system setup process to increase tracking accuracy.

  17. Spatial and Temporal Analysis on the Distribution of Active Radio-Frequency Identification (RFID Tracking Accuracy with the Kriging Method

    Directory of Open Access Journals (Sweden)

    Xin Liu

    2014-10-01

    Full Text Available Radio frequency identification (RFID technology has already been applied in a number of areas to facilitate the tracking process. However, the insufficient tracking accuracy of RFID is one of the problems that impedes its wider application. Previous studies focus on examining the accuracy of discrete points RFID, thereby leaving the tracking accuracy of the areas between the observed points unpredictable. In this study, spatial and temporal analysis is applied to interpolate the continuous distribution of RFID tracking accuracy based on the Kriging method. An implementation trial has been conducted in the loading and docking area in front of a warehouse to validate this approach. The results show that the weak signal area can be easily identified by the approach developed in the study. The optimum distance between two RFID readers and the effect of the sudden removal of readers are also presented by analysing the spatial and temporal variation of RFID tracking accuracy. This study reveals the correlation between the testing time and the stability of RFID tracking accuracy. Experimental results show that the proposed approach can be used to assist the RFID system setup process to increase tracking accuracy.

  18. Sacred activity by the Method of Excavation

    Directory of Open Access Journals (Sweden)

    Eliana Anjos Furtado

    2014-04-01

    Full Text Available Excavation is a clinical and teaching methodology created by the first author of this article. It constitutes a way of helping subjects think, make and speak. This process occurs through the xcavation of making, unblinding and/or unveiling elements in search for the understanding of sacred activity. Through xcavation, subjects understand their thoughts, values and the society in which they live in as they excavate their life stories and their relations with making, including their daily, social and work activities. We applied a thoughtful analysis to approach the role of excavation and the concept of sacred activity. Sacred activity is the core activity of every human being, which is not necessarily the activity we perform in our everyday or work life. Sacred activity is that in which subjects are inserted and experience integrally, genuinely and with no masking. Through sacred activities, subjects surrender, not only to the activity itself, but also to the other, to himself and into himself, by quest. Seeking sacred activity is, therefore, a process of questioning, excavating the routine of subjects, watching and understanding the content of this excavation, replacing and adjusting what is being unveiled, and thus making this activity sacred. In this analysis, we concluded that, by the method of excavation, the sacralization of this action should allow subjects to have tender relationships, and thus be cured.

  19. METHODS OF MAGNETOTELLURIC ANALYSIS

    Science.gov (United States)

    Magnetotelluric prospecting is a method of geophysical exploration that makes use of the fluctuations in the natural electric and magnetic fields...function of the conductivity structure of the earth’s substrata. This report describes some new methods for analyzing and interpreting magnetotelluric

  20. A new method based on fractal variance function for analysis and quantification of sympathetic and vagal activity in variability of R-R time series in ECG signals

    Energy Technology Data Exchange (ETDEWEB)

    Conte, Elio [Department of Pharmacology and Human Physiology and Tires, Center for Innovative Technologies for Signal Detection and Processing, University of Bari, Bari (Italy); School of Advanced International Studies on Nuclear, Theoretical and Nonlinear Methodologies-Bari (Italy)], E-mail: fisio2@fisiol.uniba.it; Federici, Antonio [Department of Pharmacology and Human Physiology and Tires, Center for Innovative Technologies for Signal Detection and Processing, University of Bari, Bari (Italy); Zbilut, Joseph P. [Department of Molecular Biophysics and Physiology, Rush University Medical Center, 1653W Congress, Chicago, IL 60612 (United States)

    2009-08-15

    It is known that R-R time series calculated from a recorded ECG, are strongly correlated to sympathetic and vagal regulation of the sinus pacemaker activity. In human physiology it is a crucial question to estimate such components with accuracy. Fourier analysis dominates still to day the data analysis efforts of such data ignoring that FFT is valid under some crucial restrictions that results largely violated in R-R time series data as linearity and stationarity. In order to go over such approach, we introduce a new method, called CZF. It is based on variogram analysis. It is aimed from a profound link with Recurrence Quantification Analysis that is a basic tool for investigation of non linear and non stationary time series. Therefore, a relevant feature of the method is that it finally may be applied also in cases of non linear and non stationary time series analysis. In addition, the method enables also to analyze the fractal variance function, the Generalized Fractal Dimension and, finally, the relative probability density function of the data. The CZF gives very satisfactory results. In the present paper it has been applied to direct experimental cases of normal subjects, patients with hypertension before and after therapy and in children under some different conditions of experimentation.

  1. Instrumental neutron activation analysis of geochemical samples by k{sub 0} standardization method using short lived nuclides

    Energy Technology Data Exchange (ETDEWEB)

    Oura, Yasuji; Kanzaki, Chinatsu; Ebihara, Mitsuru [Tokyo Metropolitan Univ., Graduate School of Science, Tokyo (Japan)

    2003-03-01

    Mg, Al, Ca, Ti, V, and Mn contents in geochemical and cosmochemical samples were analyzed by both k{sub 0} standardization INAA and conventional INAA by a comparison method. The contents of Mg, Al, and Mn by k{sub 0} method were consistent with recommended values and ones by comparison methods. For Ti and V their values are slightly higher than recommended ones. The values by k{sub 0} method were reliable within {+-}10%. (author)

  2. Analysis of medicinal plant extracts by neutron activation method; Analise de extratos de plantas medicinais pelo metodo de ativacao com neutrons

    Energy Technology Data Exchange (ETDEWEB)

    Vaz, Sandra Muntz

    1995-12-31

    This dissertation has presented the results from analysis of medicinal plant extracts using neutron activation method. Instrumental neutron activation analysis was applied to the determination of the elements Al, Br, Ca, Ce, Cl, Cr, Cs, Fe, K, La, Mg, Mn, Na, Rb, Sb, Sc and Zn in medicinal extracts obtained from Achyrolcline satureoides DC, Casearia sylvestris, Centella asiatica, Citrus aurantium L., Solano lycocarpum, Solidago microglossa, Stryphnondedron barbatiman and Zingiber officinale R. plants. The elements Hg and Se were determined using radiochemical separation by means of retention of Se in HMD inorganic exchanger and solvent extraction of Hg by bismuth diethyl-dithiocarbamate solution. Precision and accuracy of the results have been evaluated by analysing reference materials. The therapeutic action of some elements found in plant extracts analyzed was briefly discussed 70 refs., 13 figs., 15 tabs

  3. Implementation of the k{sub 0}-standardization Method for an Instrumental Neutron Activation Analysis: Use-k{sub 0}-IAEA Software as a Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Yong Sam; Moon, Jong Hwa; Kim, Sun Ha; Kim, Hark Rho [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of); Ho, Manh Dung [Nuclear Research Institute, Dalat (Viet Nam)

    2006-03-15

    Under the RCA post-doctoral program, from May 2005 through February 2006, it was an opportunity to review the present work being carried out in the Neutron Activation Analysis Laboratory, HANARO Center, KAERI. The scope of this research included: a calibration of the counting system, a characterization of the irradiation facility ,a validation of the established k{sub o}-NAA procedure.The k{sub o}-standardization method for an Neutron Activation Analysis(k{sub o}-NAA), which is becoming increasingly popular and widespread,is an absolute calibration technique where the nuclear data are replaced by compound nuclear constants which are experimentally determined. The k{sub o}-IAEA software distributed by the IAEA in 2005 was used as a demonstration for this work. The NAA no. 3 irradiation hole in the HANARO research reactor and the gamma-ray spectrometers No. 1 and 5 in the NAA Laboratory were used.

  4. Methods in algorithmic analysis

    CERN Document Server

    Dobrushkin, Vladimir A

    2009-01-01

    …helpful to any mathematics student who wishes to acquire a background in classical probability and analysis … This is a remarkably beautiful book that would be a pleasure for a student to read, or for a teacher to make into a year's course.-Harvey Cohn, Computing Reviews, May 2010

  5. Studies on application of neutron activation analysis -Applied research on air pollution monitoring and development of analytical method of environmental samples

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Yong Sam; Moon, Jong Hwa; Chung, Young Ju; Jeong, Eui Sik; Lee, Sang Mi; Kang, Sang Hun; Cho, Seung Yeon; Kwon, Young Sik; Chung, Sang Wuk; Lee, Kyu Sung; Chun, Ki Hong; Kim, Nak Bae; Lee, Kil Yong; Yoon, Yoon Yeol; Chun, Sang Ki

    1997-09-01

    This research report is written for results of applied research on air pollution monitoring using instrumental neutron activation analysis. For identification and standardization of analytical method, 24 environmental samples are analyzed quantitatively, and accuracy and precision of this method are measured. Using airborne particulate matter and biomonitor chosen as environmental indicators, trace elemental concentrations of sample collected at urban and rural site monthly are determined ant then the calculation of statistics and the factor analysis are carried out for investigation of emission source. Facilities for NAA are installed in a new HANARO reactor, functional test is performed for routine operation. In addition, unified software code for NAA is developed to improve accuracy, precision and abilities of analytical processes. (author). 103 refs., 61 tabs., 19 figs.

  6. USE OF STATISTICAL METHODS IN DETECTING ACCOUNTING ENGINEERING ACTIVITIES (AS EXEMPLIFIED BY THE ACCOUNTING SYSTEM IN POLAND – SECOND PART: EMPIRICAL ASPECTS OF ANALYSIS

    Directory of Open Access Journals (Sweden)

    Leszek Michalczyk

    2013-10-01

    Full Text Available This article is one in a series of two publications concerning detection of accounting engineering operations in use. Its conclusions and methods may be applied to external auditing procedures. The aim of the present duo-article is to define a method of statistical analysis that could identify procedures falling within the scope of a framework herein defined as accounting engineering. This model for analysis is meant to be employed in these aspects of initial financial and accounting audit in a business enterprise that have to do with isolating the influence of variant accounting solutions, which are a consequence of the settlement method chosen by the enterprise. Materials for statistical analysis were divided into groups according to the field in which a given company operated. In this article, we accept and elaborate on the premise that significant differences in financial results may be solely a result of either expansive policy on new markets or the acquisition of cheaper sources for operating activities. In the remaining cases, the choice of valuation and settlement methods becomes crucial; the greater the deviations, the more essential this choice becomes. Even though the research materials we analyze are regionally-conditioned, the model may find its application in other accounting systems, provided that it has been appropriately implemented. Furthermore, the article defines an innovative concept of variant accounting.

  7. Comparative analysis of radical scavenging and antioxidant activity of phenolic compounds present in everyday use spice plants by means of spectrophotometric and chromatographic methods.

    Science.gov (United States)

    Stankevičius, Mantas; Akuņeca, Ieva; Jãkobsone, Ida; Maruška, Audrius

    2011-06-01

    Comparative analysis of radical scavenging and antioxidant activities of phenolic compounds present in everyday use spice plants was carried out by means of spectrophotometric and chromatographic methods. Six spice plant samples, namely onion (Allium cepa), parsley (Petroselinum crispum) roots and leaves, celery (Apium graveolens) roots and leaves and leaves of dill (Anethum graveolens) were analyzed. Total amount of phenolic compounds and radical scavenging activity (RSA) was the highest in celery leaves and dill extracts and was the lowest in celery roots. Comparing commonly used spectrophotometric analysis of 2,2-diphenyl-1-picrylhydrazyl (DPPH) RSA of extracts with the results obtained using reversed-phase chromatographic separation with on-line post-column radical scavenging reaction detection, good correlation was obtained (R(2)=0.848). Studies using HPLC system with electrochemical detector showed that bioactive phytochemicals can be separated and antioxidant activities of individual compounds evaluated without the need of a complex HPLC system with reaction detector. The results obtained using electrochemical detection correlate with the RSA assayed using spectrophotometric method (R(2)=0.893).

  8. Socioeconomic Methods in Educational Analysis.

    Science.gov (United States)

    Weber, William H., III

    This book explores the possibilities in a new approach to educational analysis--a fusion of methods drawn from economics, sociology, and social psychology. The author combines his explanation of socioeconomic analysis with the presentation of several examples that illustrate the application of his method to different analytical problems. The book…

  9. Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides

    Directory of Open Access Journals (Sweden)

    Lohner Karl

    2008-11-01

    Full Text Available Abstract Background Growing concerns about bacterial resistance to antibiotics have prompted the development of alternative therapies like those based on cationic antimicrobial peptides (APs. These compounds not only are bactericidal by themselves but also enhance the activity of antibiotics. Studies focused on the systematic characterization of APs are hampered by the lack of standard guidelines for testing these compounds. We investigated whether the information provided by methods commonly used for the biological characterization of APs is comparable, as it is often assumed. For this purpose, we determined the bacteriostatic, bactericidal, and permeability-increasing activity of synthetic peptides (n = 57; 9–13 amino acid residues in length analogous to the lipopolysaccharide-binding region of human lactoferricin by a number of the most frequently used methods and carried out a comparative analysis. Results While the minimum inhibitory concentration determined by an automated turbidimetry-based system (Bioscreen or by conventional broth microdilution methods did not differ significantly, bactericidal activity measured under static conditions in a low-ionic strength solvent resulted in a vast overestimation of antimicrobial activity. Under these conditions the degree of antagonism between the peptides and the divalent cations differed greatly depending on the bacterial strain tested. In contrast, the bioactivity of peptides was not affected by the type of plasticware (polypropylene vs. polystyrene. Susceptibility testing of APs using cation adjusted Mueller-Hinton was the most stringent screening method, although it may overlook potentially interesting peptides. Permeability assays based on sensitization to hydrophobic antibiotics provided overall information analogous – though not quantitatively comparable- to that of tests based on the uptake of hydrophobic fluorescent probes. Conclusion We demonstrate that subtle changes in methods for

  10. COMPETITIVE INTELLIGENCE ANALYSIS - SCENARIOS METHOD

    Directory of Open Access Journals (Sweden)

    Ivan Valeriu

    2014-07-01

    Full Text Available Keeping a company in the top performing players in the relevant market depends not only on its ability to develop continually, sustainably and balanced, to the standards set by the customer and competition, but also on the ability to protect its strategic information and to know in advance the strategic information of the competition. In addition, given that economic markets, regardless of their profile, enable interconnection not only among domestic companies, but also between domestic companies and foreign companies, the issue of economic competition moves from the national economies to the field of interest of regional and international economic organizations. The stakes for each economic player is to keep ahead of the competition and to be always prepared to face market challenges. Therefore, it needs to know as early as possible, how to react to others’ strategy in terms of research, production and sales. If a competitor is planning to produce more and cheaper, then it must be prepared to counteract quickly this movement. Competitive intelligence helps to evaluate the capabilities of competitors in the market, legally and ethically, and to develop response strategies. One of the main goals of the competitive intelligence is to acknowledge the role of early warning and prevention of surprises that could have a major impact on the market share, reputation, turnover and profitability in the medium and long term of a company. This paper presents some aspects of competitive intelligence, mainly in terms of information analysis and intelligence generation. Presentation is theoretical and addresses a structured method of information analysis - scenarios method – in a version that combines several types of analysis in order to reveal some interconnecting aspects of the factors governing the activity of a company.

  11. Development of the Method of Bacterial Leaching of Metals out of Low-Grade Ores, Rocks, and Industrial Wastes Using Neutron Activation Analysis

    CERN Document Server

    Tsertsvadze, L A; Petriashvili, Sh G; Chutkerashvili, D G; Kirkesali, E I; Frontasyeva, M V; Pavlov, S S; Gundorina, S F

    2001-01-01

    The results of preliminary investigations aimed at the development of an economical and easy to apply technique of bacterial leaching of rare and valuable metals out of low-grade ores, complex composition ores, rocks, and industrial wastes in Georgia are discussed. The main groups of microbiological community of the peat suspension used in the experiments of bacterial leaching are investigated and the activity of particular microorganisms in the leaching of probes with different mineral compositions is assessed. The element composition of the primary and processed samples was investigated by the epithermal neutron activation analysis method and the enrichment/subtraction level is estimated for various elements. The efficiency of the developed technique to purify wastes, extract some scrace metals, and enrich ores or rocks in some elements, e.g. Au, U, Th, Cs, Sr, Rb, Sc, Zr, Hf, Ta, Gd, Er, Lu, Ce, etc., is demonstrated.

  12. Establishing a High-content Analysis Method for Tubulin Polymerization to Evaluate Both the Stabilizing and Destabilizing Activities of Compounds.

    Science.gov (United States)

    Sum, Chi Shing; Nickischer, Debra; Lei, Ming; Weston, Andrea; Zhang, Litao; Schweizer, Liang

    2014-01-01

    Microtubules are important components of the cellular cytoskeleton that play roles in various cellular processes such as vesicular transport and spindle formation during mitosis. They are formed by an ordered organization of α-tubulin and β-tubulin hetero-polymers. Altering microtubule polymerization has been known to be the mechanism of action for a number of therapeutically important drugs including taxanes and epothilones. Traditional cell-based assays for tubulin-interacting compounds rely on their indirect effects on cell cycle and/or cell proliferation. Direct monitoring of compound effects on microtubules is required to dissect detailed mechanisms of action in a cellular setting. Here we report a high-content assay platform to monitor tubulin polymerization status by directly measuring the acute effects of drug candidates on the cellular tubulin network with the capability to dissect the mechanisms of action. This high-content analysis distinguishes in a quantitative manner between compounds that act as tubulin stabilizers versus those that are tubulin destabilizers. In addition, using a multiplex approach, we expanded this analysis to simultaneously monitor physiological cellular responses and associated cellular phenotypes.

  13. The Method of Relative Evaluations in the Analysis of the Innovation and Scientific-Technical Activity in the National Innovation System

    Directory of Open Access Journals (Sweden)

    Melnyk Alexander G.

    2017-04-01

    Full Text Available The article suggests the methodical approach to calculation of the system of analytical indicators for complex analysis of the innovation and scientific-technical activity by defining indexes such as: implementarity of technologies; institutional fullness of the national innovation system (NIS; high technology grade of the industry branches and sectors of the NIS. Fundamentals on the interpretation of these indicators in determining the status of institutional and technological structures, as well as the investment ability of technologies in the NIS, have been formulated. An evaluation of status of the innovation and scientific-technical activity in the industry and in the sector of scientific organizations of Ukraine was carried out on the example of practical application of the methodical approach to the analysis of statistical data. A simulation of the calculation index of implementarity of technologies in terms of the hypothesis of a 10 x magnification of the number of patents for inventions was completed. The author’s own interpretation of values of the calculated indicators has been proposed.

  14. Conference on Instrumental Activation Analysis: IAA 89

    Science.gov (United States)

    Vobecky, M.; Obrusnik, I.

    1989-05-01

    The proceedings contain 40 abstracts of papers all of which have been incorporated in INIS. The papers were centred on the applications of radioanalytical methods, especially on neutron activation analysis, x ray fluorescence analysis, PIXE analysis and tracer techniques in biology, medicine and metallurgy, measuring instruments including microcomputers, and data processing methods.

  15. Probabilistic methods for rotordynamics analysis

    Science.gov (United States)

    Wu, Y.-T.; Torng, T. Y.; Millwater, H. R.; Fossum, A. F.; Rheinfurth, M. H.

    1991-01-01

    This paper summarizes the development of the methods and a computer program to compute the probability of instability of dynamic systems that can be represented by a system of second-order ordinary linear differential equations. Two instability criteria based upon the eigenvalues or Routh-Hurwitz test functions are investigated. Computational methods based on a fast probability integration concept and an efficient adaptive importance sampling method are proposed to perform efficient probabilistic analysis. A numerical example is provided to demonstrate the methods.

  16. Simultaneous analysis of 11 main active components in Cirsium setosum based on HPLC-ESI-MS/MS and combined with statistical methods.

    Science.gov (United States)

    Sun, Qian; Chang, Lu; Ren, Yanping; Cao, Liang; Sun, Yingguang; Du, Yingfeng; Shi, Xiaowei; Wang, Qiao; Zhang, Lantong

    2012-11-01

    A novel method based on high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry was developed for simultaneous determination of the 11 major active components including ten flavonoids and one phenolic acid in Cirsium setosum. Separation was performed on a reversed-phase C(18) column with gradient elution of methanol and 0.1‰ acetic acid (v/v). The identification and quantification of the analytes were achieved on a hybrid quadrupole linear ion trap mass spectrometer. Multiple-reaction monitoring scanning was employed for quantification with switching electrospray ion source polarity between positive and negative modes in a single run. Full validation of the assay was carried out including linearity, precision, accuracy, stability, limits of detection and quantification. The results demonstrated that the method developed was reliable, rapid, and specific. The 25 batches of C. setosum samples from different sources were first determined using the developed method and the total contents of 11 analytes ranged from 1717.460 to 23028.258 μg/g. Among them, the content of linarin was highest, and its mean value was 7340.967 μg/g. Principal component analysis and hierarchical clustering analysis were performed to differentiate and classify the samples, which is helpful for comprehensive evaluation of the quality of C. setosum.

  17. Activating teaching methods in french language teaching

    OpenAIRE

    Kulhánková, Anna

    2009-01-01

    The subject of this diploma thesis is activating teaching methods in french language teaching. This thesis outlines the issues acitvating teaching methods in the concept of other teaching methods. There is a definition of teaching method, classification of teaching methods and characteristics of each activating method. In the practical part of this work are given concrete forms of activating teaching methods appropriate for teaching of french language.

  18. MHHT-Based Method for Analysis of Micro-Doppler Signatures for Human Finer-Grained Activity Using Through-Wall SFCW Radar

    Directory of Open Access Journals (Sweden)

    Fugui Qi

    2017-03-01

    Full Text Available Ultra-wideband radar-based penetrating detection and recognition of human activities has become a focus on remote sensing in various military applications in recent years, such as urban warfare, hostage rescue, and earthquake post-disaster rescue. However, an excellent micro-Doppler signature (MDS extracting method of human motion with high time-frequency resolution, outstanding anti-interference ability, and extensive adaptability, which aims to provide favorable and more detailed features for human activity recognition and classification, especially in the non-free space detection environment, is in great urgency. To cope with the issue, a multiple Hilbert-Huang transform (MHHT method is proposed for high-resolution time-frequency analysis of finer-grained human activity MDS hidden in ultra-wideband (UWB radar echoes during the through-wall detection environment. Based on the improved HHT with effective intrinsic mode function (IMF selection according to the cosine similarity (CS principle, the improved HHT is applied to each channel signal in the effective channel scope of the UWB radar signal and then integrated along the range direction. The activities of swinging one or two arms while standing at a spot 3 m from a wall were used to validate the abilities of the proposed method for extracting and separating the MDS of different moving body structures with a high time-frequency resolution. Simultaneously, the corresponding relationship between the frequency components in MHHT-based spectra and structures of the moving human body was demonstrated according to the radar Doppler principle combined with the principle of human body kinematics. Moreover, six common finer-grained human activities and a piaffe at different ranges under the through-wall detection environment were exploited to confirm the adaptability of the novel method for different activities and pre-eminent anti-interference ability under a low signal-noise-clutter ratio (SNCR

  19. Nonlinear programming analysis and methods

    CERN Document Server

    Avriel, Mordecai

    2012-01-01

    This text provides an excellent bridge between principal theories and concepts and their practical implementation. Topics include convex programming, duality, generalized convexity, analysis of selected nonlinear programs, techniques for numerical solutions, and unconstrained optimization methods.

  20. A new method based on low background instrumental neutron activation analysis for major, trace and ultra-trace element determination in atmospheric mineral dust from polar ice cores

    Energy Technology Data Exchange (ETDEWEB)

    Baccolo, Giovanni, E-mail: giovanni.baccolo@mib.infn.it [Graduate School in Polar Sciences, University of Siena, Via Laterina 8, 53100, Siena (Italy); Department of Environmental Sciences, University of Milano-Bicocca, P.zza della Scienza 1, 20126, Milano (Italy); INFN, Section of Milano-Bicocca, P.zza della Scienza 3, 20126, Milano (Italy); Clemenza, Massimiliano [INFN, Section of Milano-Bicocca, P.zza della Scienza 3, 20126, Milano (Italy); Department of Physics, University of Milano-Bicocca, P.zza della Scienza 3, 20126, Milano (Italy); Delmonte, Barbara [Department of Environmental Sciences, University of Milano-Bicocca, P.zza della Scienza 1, 20126, Milano (Italy); Maffezzoli, Niccolò [Centre for Ice and Climate, Niels Bohr Institute, Juliane Maries Vej, 30, 2100, Copenhagen (Denmark); Nastasi, Massimiliano; Previtali, Ezio [INFN, Section of Milano-Bicocca, P.zza della Scienza 3, 20126, Milano (Italy); Department of Physics, University of Milano-Bicocca, P.zza della Scienza 3, 20126, Milano (Italy); Prata, Michele; Salvini, Andrea [LENA, University of Pavia, Pavia (Italy); Maggi, Valter [Department of Environmental Sciences, University of Milano-Bicocca, P.zza della Scienza 1, 20126, Milano (Italy); INFN, Section of Milano-Bicocca, P.zza della Scienza 3, 20126, Milano (Italy)

    2016-05-30

    Dust found in polar ice core samples present extremely low concentrations, in addition the availability of such samples is usually strictly limited. For these reasons the chemical and physical analysis of polar ice cores is an analytical challenge. In this work a new method based on low background instrumental neutron activation analysis (LB-INAA) for the multi-elemental characterization of the insoluble fraction of dust from polar ice cores is presented. Thanks to an accurate selection of the most proper materials and procedures it was possible to reach unprecedented analytical performances, suitable for ice core analyses. The method was applied to Antarctic ice core samples. Five samples of atmospheric dust (μg size) from ice sections of the Antarctic Talos Dome ice core were prepared and analyzed. A set of 37 elements was quantified, spanning from all the major elements (Na, Mg, Al, Si, K, Ca, Ti, Mn and Fe) to trace ones, including 10 (La, Ce, Nd, Sm, Eu, Tb, Ho, Tm, Yb and Lu) of the 14 natural occurring lanthanides. The detection limits are in the range of 10{sup −13}–10{sup −6} g, improving previous results of 1–3 orders of magnitude depending on the element; uncertainties lies between 4% and 60%. - Highlights: • A new method based on neutron activation for the multi-elemental characterization of atmospheric dust entrapped in polar ice cores is proposed. • 37 elements were quantified in μg size dust samples with detection limits ranging from 10{sup −13} to 10{sup −6} g. • A low background approach and a clean analytical protocol improved INAA performances to unprecedented levels for multi-elemental analyses.

  1. Bayesian Methods for Statistical Analysis

    OpenAIRE

    Puza, Borek

    2015-01-01

    Bayesian methods for statistical analysis is a book on statistical methods for analysing a wide variety of data. The book consists of 12 chapters, starting with basic concepts and covering numerous topics, including Bayesian estimation, decision theory, prediction, hypothesis testing, hierarchical models, Markov chain Monte Carlo methods, finite population inference, biased sampling and nonignorable nonresponse. The book contains many exercises, all with worked solutions, including complete c...

  2. A new method based on low background instrumental neutron activation analysis for major, trace and ultra-trace element determination in atmospheric mineral dust from polar ice cores.

    Science.gov (United States)

    Baccolo, Giovanni; Clemenza, Massimiliano; Delmonte, Barbara; Maffezzoli, Niccolò; Nastasi, Massimiliano; Previtali, Ezio; Prata, Michele; Salvini, Andrea; Maggi, Valter

    2016-05-30

    Dust found in polar ice core samples present extremely low concentrations, in addition the availability of such samples is usually strictly limited. For these reasons the chemical and physical analysis of polar ice cores is an analytical challenge. In this work a new method based on low background instrumental neutron activation analysis (LB-INAA) for the multi-elemental characterization of the insoluble fraction of dust from polar ice cores is presented. Thanks to an accurate selection of the most proper materials and procedures it was possible to reach unprecedented analytical performances, suitable for ice core analyses. The method was applied to Antarctic ice core samples. Five samples of atmospheric dust (μg size) from ice sections of the Antarctic Talos Dome ice core were prepared and analyzed. A set of 37 elements was quantified, spanning from all the major elements (Na, Mg, Al, Si, K, Ca, Ti, Mn and Fe) to trace ones, including 10 (La, Ce, Nd, Sm, Eu, Tb, Ho, Tm, Yb and Lu) of the 14 natural occurring lanthanides. The detection limits are in the range of 10(-13)-10(-6) g, improving previous results of 1-3 orders of magnitude depending on the element; uncertainties lies between 4% and 60%.

  3. A new method for FMRI activation detection

    Science.gov (United States)

    Wei, Jianing; Talavage, Thomas M.; Pollak, Ilya

    2009-02-01

    The objective of fMRI data analysis is to detect the region of the brain that gets activated in response to a specific stimulus presented to the subject. We develop a new algorithm for activation detection in event-related fMRI data. We utilize a forward model for fMRI data acquisition which explicitly incorporates physiological noise, scanner noise and the spatial blurring introduced by the scanner. After slice-by-slice image restoration procedure that independently restores each data slice corresponding to each time index, we estimate the parameters of the hemodynamic response function (HRF) model for each pixel of the restored data. In order to enforce spatial regularity in our estimates, we model the prior distribution of the HRF parameters as a generalized Gaussian Markov random field (GGMRF) model. We develop an algorithm to compute the maximum a posteriori (MAP) estimates of the parameters. We then threshold the amplitude parameters to obtain the final activation map. We illustrate our algorithm by comparing it with the widely used general linear model (GLM) method. In synthetic data experiments, under the same probability of false alarm, the probability of correct detection for our method is up to 15% higher than GLM. In real data experiments, through anatomical analysis and benchmark testing using block paradigm results, we demonstrate that our algorithm produces fewer false alarms than GLM.

  4. Accurate determination of arsenic in arsenobetaine standard solutions of BCR-626 and NMIJ CRM 7901-a by neutron activation analysis coupled with internal standard method.

    Science.gov (United States)

    Miura, Tsutomu; Chiba, Koichi; Kuroiwa, Takayoshi; Narukawa, Tomohiro; Hioki, Akiharu; Matsue, Hideaki

    2010-09-15

    Neutron activation analysis (NAA) coupled with an internal standard method was applied for the determination of As in the certified reference material (CRM) of arsenobetaine (AB) standard solutions to verify their certified values. Gold was used as an internal standard to compensate for the difference of the neutron exposure in an irradiation capsule and to improve the sample-to-sample repeatability. Application of the internal standard method significantly improved linearity of the calibration curve up to 1 microg of As, too. The analytical reliability of the proposed method was evaluated by k(0)-standardization NAA. The analytical results of As in AB standard solutions of BCR-626 and NMIJ CRM 7901-a were (499+/-55)mgkg(-1) (k=2) and (10.16+/-0.15)mgkg(-1) (k=2), respectively. These values were found to be 15-20% higher than the certified values. The between-bottle variation of BCR-626 was much larger than the expanded uncertainty of the certified value, although that of NMIJ CRM 7901-a was almost negligible.

  5. In situ mineralogical-chemical analysis of Martian materials at landing/roving sites by active and passive remote sensing methods

    Science.gov (United States)

    Neukum, G.; Lehmann, F.; Regner, P.; Jaumann, R.

    1988-01-01

    Remote sensing of the Martian surface from the ground and from orbiting spacecraft has provided some first-order insight into the mineralogical-chemical composition and the weathering state of Martian surface materials. Much more detailed information can be gathered from performing such measurements in situ at the landing sites or from a rover in combination with analogous measurements from orbit. Measurements in the wavelength range of approximately 0.3 to 12.0 micrometers appear to be suitable to characterize much of the physical, mineralogical, petrological, and chemical properties of Martian surface materials and the weathering and other alteration processes that have acted on them. It is of particular importance to carry out measurements at the same time over a broad wavelength range since the reflectance signatures are caused by different effects and hence give different and complementing information. It appears particularly useful to employ a combination of active and passive methods because the use of active laser spectroscopy allows the obtaining of specific information on thermal infrared reflectance of surface materials. It seems to be evident that a spectrometric survey of Martian materials has to be focused on the analysis of altered and fresh mafic materials and rocks, water-bearing silicates, and possibly carbonates.

  6. Development of a technique using MCNPX code for determination of nitrogen content of explosive materials using prompt gamma neutron activation analysis method

    Energy Technology Data Exchange (ETDEWEB)

    Nasrabadi, M.N., E-mail: mnnasrabadi@ast.ui.ac.ir [Department of Nuclear Engineering, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan 81746-73441 (Iran, Islamic Republic of); Bakhshi, F.; Jalali, M.; Mohammadi, A. [Department of Nuclear Engineering, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan 81746-73441 (Iran, Islamic Republic of)

    2011-12-11

    Nuclear-based explosive detection methods can detect explosives by identifying their elemental components, especially nitrogen. Thermal neutron capture reactions have been used for detecting prompt gamma 10.8 MeV following radioactive neutron capture by {sup 14}N nuclei. We aimed to study the feasibility of using field-portable prompt gamma neutron activation analysis (PGNAA) along with improved nuclear equipment to detect and identify explosives, illicit substances or landmines. A {sup 252}Cf radio-isotopic source was embedded in a cylinder made of high-density polyethylene (HDPE) and the cylinder was then placed in another cylindrical container filled with water. Measurements were performed on high nitrogen content compounds such as melamine (C{sub 3}H{sub 6}N{sub 6}). Melamine powder in a HDPE bottle was placed underneath the vessel containing water and the neutron source. Gamma rays were detected using two NaI(Tl) crystals. The results were simulated with MCNP4c code calculations. The theoretical calculations and experimental measurements were in good agreement indicating that this method can be used for detection of explosives and illicit drugs.

  7. Active and passive cooling methods for dwellings

    DEFF Research Database (Denmark)

    Oropeza-Perez, Ivan; Østergaard, Poul Alberg

    2018-01-01

    they might be applied, and what their energy needs are. Secondly, what scientific analysis has been carried out and what the major findings are. Thirdly, what their economic and technical feasibility of use at the stage of implementation and operation within a dwelling are. Then, either with the reviewed......In this document a review of three active as well as ten passive cooling methods suitable for residential buildings is carried out. The review firstly addresses how the various technologies cool the space according to the terms of the building heat balance, under what technical conditions...... studies or with a simulation modelling, an assessment of temperature drop of each cooling method within a standard-size dwelling is carried out. Also, a comparison of initial investment, energy consumption, maintenance, retrofitting and required space is done. Thereafter, with this information, a decision...

  8. SWOT ANALYSIS ON SAMPLING METHOD

    Directory of Open Access Journals (Sweden)

    CHIS ANCA OANA

    2014-07-01

    Full Text Available Audit sampling involves the application of audit procedures to less than 100% of items within an account balance or class of transactions. Our article aims to study audit sampling in audit of financial statements. As an audit technique largely used, in both its statistical and nonstatistical form, the method is very important for auditors. It should be applied correctly for a fair view of financial statements, to satisfy the needs of all financial users. In order to be applied correctly the method must be understood by all its users and mainly by auditors. Otherwise the risk of not applying it correctly would cause loose of reputation and discredit, litigations and even prison. Since there is not a unitary practice and methodology for applying the technique, the risk of incorrectly applying it is pretty high. The SWOT analysis is a technique used that shows the advantages, disadvantages, threats and opportunities. We applied SWOT analysis in studying the sampling method, from the perspective of three players: the audit company, the audited entity and users of financial statements. The study shows that by applying the sampling method the audit company and the audited entity both save time, effort and money. The disadvantages of the method are difficulty in applying and understanding its insight. Being largely used as an audit method and being a factor of a correct audit opinion, the sampling method’s advantages, disadvantages, threats and opportunities must be understood by auditors.

  9. Use of statistical methods in detecting accounting engineering activities (as exemplified by the accounting system in Poland) - First part: Theoretical aspects of analysis

    OpenAIRE

    Michalczyk, Leszek

    2013-01-01

    This article is one in a series of two publications concerning companies' detection of accounting engineering operations in use. Its conclusions and methods may be applied to external auditing procedures. The aim of the present duo-article is to define a method of statistical analysis that could identify procedures falling within the scope of a framework herein defined as accounting engineering. This model for analysis is meant to be employed in these aspects of initial financial and accounti...

  10. USE OF STATISTICAL METHODS IN DETECTING ACCOUNTING ENGINEERING ACTIVITIES (AS EXEMPLIFIED BY THE ACCOUNTING SYSTEM IN POLAND) – SECOND PART: EMPIRICAL ASPECTS OF ANALYSIS

    OpenAIRE

    Leszek Michalczyk

    2013-01-01

    This article is one in a series of two publications concerning detection of accounting engineering operations in use. Its conclusions and methods may be applied to external auditing procedures. The aim of the present duo-article is to define a method of statistical analysis that could identify procedures falling within the scope of a framework herein defined as accounting engineering. This model for analysis is meant to be employed in these aspects of initial financial and accounting audit in...

  11. Statistical methods for bioimpedance analysis

    Directory of Open Access Journals (Sweden)

    Christian Tronstad

    2014-04-01

    Full Text Available This paper gives a basic overview of relevant statistical methods for the analysis of bioimpedance measurements, with an aim to answer questions such as: How do I begin with planning an experiment? How many measurements do I need to take? How do I deal with large amounts of frequency sweep data? Which statistical test should I use, and how do I validate my results? Beginning with the hypothesis and the research design, the methodological framework for making inferences based on measurements and statistical analysis is explained. This is followed by a brief discussion on correlated measurements and data reduction before an overview is given of statistical methods for comparison of groups, factor analysis, association, regression and prediction, explained in the context of bioimpedance research. The last chapter is dedicated to the validation of a new method by different measures of performance. A flowchart is presented for selection of statistical method, and a table is given for an overview of the most important terms of performance when evaluating new measurement technology.

  12. Method for Systematic Assessment of Chemical Changes in Molecular Scaffolds with Conserved Topology and Application to the Analysis of Scaffold-Activity Relationships.

    Science.gov (United States)

    Hu, Ye; Zhang, Bijun; Bajorath, Jürgen

    2015-08-01

    Sets of scaffolds with conserved molecular topology are abundant among drugs and bioactive compounds. Core structure topology is one of the determinants of biological activity. Heteroatom replacements and/or bond order variation render topologically equivalent scaffolds chemically distinct and also contribute to differences in the biological activity of compounds containing these scaffolds. Relationships between core structure topology, chemical modifications, and observed activity profiles are difficult to analyze. A computational method is introduced to consistently assess chemical transformations that distinguish scaffolds with conserved topology. The methodology is applied to quantify chemical differences in conserved topological environments and systematically relate chemical changes in topologically equivalent scaffolds to associated activity profiles.

  13. Analysis methods for airborne radioactivity

    OpenAIRE

    Ala-Heikkilä, Jarmo J

    2008-01-01

    High-resolution gamma-ray spectrometry is an analysis method well suitable for monitoring airborne radioactivity. Many of the natural radionuclides and a majority of anthropogenic nuclides are prominent gamma-ray emitters. With gamma-ray spectrometry different radionuclides are readily observed at minute concentrations that are far from health hazards. The gamma-ray spectrometric analyses applied in air monitoring programmes can be divided into particulate measurements and gas measurements. I...

  14. Nonlinear programming analysis and methods

    CERN Document Server

    Avriel, Mordecai

    2003-01-01

    Comprehensive and complete, this overview provides a single-volume treatment of key algorithms and theories. The author provides clear explanations of all theoretical aspects, with rigorous proof of most results. The two-part treatment begins with the derivation of optimality conditions and discussions of convex programming, duality, generalized convexity, and analysis of selected nonlinear programs. The second part concerns techniques for numerical solutions and unconstrained optimization methods, and it presents commonly used algorithms for constrained nonlinear optimization problems. This g

  15. Activation of Students with Various Teaching Methods

    DEFF Research Database (Denmark)

    Andersen, Shuang Ma

    2011-01-01

    A group of teaching methodes to active engineer students have been tried out. The methodes are developed based on the Pedagogical Cyclic Workflow (PCW). Comparing with earlier evaluation, positive feedback is achieved among the students.......A group of teaching methodes to active engineer students have been tried out. The methodes are developed based on the Pedagogical Cyclic Workflow (PCW). Comparing with earlier evaluation, positive feedback is achieved among the students....

  16. Evaluation of neutron flux parameters in irradiation sites of research reactor using the Westcott-formalism for the k0 neutron activation analysis method

    Science.gov (United States)

    Kasban, H.; Hamid, Ashraf

    2015-12-01

    Instrumental Neutron Activation Analysis using k0 (k0-INAA) method has been used to determine a number of elements in sediment samples collected from El-Manzala Lake in Egypt. k0-INAA according to Westcott's formalism has been implemented using the complete irradiation kit of the fast pneumatic rabbit and some selected manually loaded irradiation sites for short and long irradiation at Egypt Second Research Reactor (ETRR-2). Zr-Au and Co sets as neutron flux monitors are used to determine the neutron flux parameters (f and α) in each irradiation sites. Two reference materials IAEA Soil-7 samples have been inserted and implemented for data validation and an internal monostandard multi monitor used (k0 based IM-NAA). It was given a good agreement between the experimental analyzed values and that obtained of the certified values. The major and trace elements in the sediment samples have been evaluated with the use of Co as an internal and Au as an external monostandard comparators. The concentrations of the elements (Cr, Mn and Zn) in the sediment samples of the present work are discussed regarding to those obtained from other sites.

  17. Application of Software Safety Analysis Methods

    Energy Technology Data Exchange (ETDEWEB)

    Park, G. Y.; Hur, S.; Cheon, S. W.; Kim, D. H.; Lee, D. Y.; Kwon, K. C. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Lee, S. J.; Koo, Y. H. [Doosan Heavy Industries and Construction Co., Daejeon (Korea, Republic of)

    2009-05-15

    A fully digitalized reactor protection system, which is called the IDiPS-RPS, was developed through the KNICS project. The IDiPS-RPS has four redundant and separated channels. Each channel is mainly composed of a group of bistable processors which redundantly compare process variables with their corresponding setpoints and a group of coincidence processors that generate a final trip signal when a trip condition is satisfied. Each channel also contains a test processor called the ATIP and a display and command processor called the COM. All the functions were implemented in software. During the development of the safety software, various software safety analysis methods were applied, in parallel to the verification and validation (V and V) activities, along the software development life cycle. The software safety analysis methods employed were the software hazard and operability (Software HAZOP) study, the software fault tree analysis (Software FTA), and the software failure modes and effects analysis (Software FMEA)

  18. Gait analysis methods in rehabilitation

    Directory of Open Access Journals (Sweden)

    Baker Richard

    2006-03-01

    Full Text Available Abstract Introduction Brand's four reasons for clinical tests and his analysis of the characteristics of valid biomechanical tests for use in orthopaedics are taken as a basis for determining what methodologies are required for gait analysis in a clinical rehabilitation context. Measurement methods in clinical gait analysis The state of the art of optical systems capable of measuring the positions of retro-reflective markers placed on the skin is sufficiently advanced that they are probably no longer a significant source of error in clinical gait analysis. Determining the anthropometry of the subject and compensating for soft tissue movement in relation to the under-lying bones are now the principal problems. Techniques for using functional tests to determine joint centres and axes of rotation are starting to be used successfully. Probably the last great challenge for optical systems is in using computational techniques to compensate for soft tissue measurements. In the long term future it is possible that direct imaging of bones and joints in three dimensions (using MRI or fluoroscopy may replace marker based systems. Methods for interpreting gait analysis data There is still not an accepted general theory of why we walk the way we do. In the absence of this, many explanations of walking address the mechanisms by which specific movements are achieved by particular muscles. A whole new methodology is developing to determine the functions of individual muscles. This needs further development and validation. A particular requirement is for subject specific models incorporating 3-dimensional imaging data of the musculo-skeletal anatomy with kinematic and kinetic data. Methods for understanding the effects of intervention Clinical gait analysis is extremely limited if it does not allow clinicians to choose between alternative possible interventions or to predict outcomes. This can be achieved either by rigorously planned clinical trials or using

  19. Active teaching methods, studying responses and learning

    DEFF Research Database (Denmark)

    Christensen, Hans Peter; Vigild, Martin Etchells; Thomsen, Erik Vilain;

    2010-01-01

    Students’ study strategies when exposed to activating teaching methods are measured, analysed and compared to study strategies in more traditional lecture-based teaching. The resulting learning outcome is discussed.......Students’ study strategies when exposed to activating teaching methods are measured, analysed and compared to study strategies in more traditional lecture-based teaching. The resulting learning outcome is discussed....

  20. Active teaching methods, studying responses and learning

    DEFF Research Database (Denmark)

    Christensen, Hans Peter; Vigild, Martin Etchells; Thomsen, Erik Vilain;

    Students’ study strategies when exposed to activating teaching methods are measured, analysed and compared to study strategies in more traditional lecture-based teaching.......Students’ study strategies when exposed to activating teaching methods are measured, analysed and compared to study strategies in more traditional lecture-based teaching....

  1. Active teaching methods, studying responses and learning

    DEFF Research Database (Denmark)

    Christensen, Hans Peter; Vigild, Martin Etchells; Thomsen, Erik Vilain

    Students’ study strategies when exposed to activating teaching methods are measured, analysed and compared to study strategies in more traditional lecture-based teaching.......Students’ study strategies when exposed to activating teaching methods are measured, analysed and compared to study strategies in more traditional lecture-based teaching....

  2. Active teaching methods, studying responses and learning

    DEFF Research Database (Denmark)

    Christensen, Hans Peter; Vigild, Martin Etchells; Thomsen, Erik Vilain

    2010-01-01

    Students’ study strategies when exposed to activating teaching methods are measured, analysed and compared to study strategies in more traditional lecture-based teaching. The resulting learning outcome is discussed.......Students’ study strategies when exposed to activating teaching methods are measured, analysed and compared to study strategies in more traditional lecture-based teaching. The resulting learning outcome is discussed....

  3. Data Analysis Methods for Paleogenomics

    DEFF Research Database (Denmark)

    Avila Arcos, Maria del Carmen

    , thanks to the introduction of NGS and the implementation of data analysis methods specific for each project. Chapters 1 to 3 have been published in peer-reviewed journals and Chapter 4 is currently in review. Chapter 5 consists of a manuscript describing initial results of an ongoing research project...... (Danmarks Grundforskningfond) 'Centre of Excellence in GeoGenetics' grant, with additional funding provided by the Danish Council for Independent Research 'Sapere Aude' programme. The thesis comprises five chapters, all of which represent different projects that involved the analysis of massive amounts...... of sequence data, generated using next-generation sequencing (NGS) technologies, from either forensic (Chapter 1) or ancient (Chapters 2-5) materials. These chapters present projects very different in nature, reflecting the diversity of questions that have become possible to address in the ancient DNA field...

  4. Hybrid methods for cybersecurity analysis :

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Warren Leon,; Dunlavy, Daniel M.

    2014-01-01

    Early 2010 saw a signi cant change in adversarial techniques aimed at network intrusion: a shift from malware delivered via email attachments toward the use of hidden, embedded hyperlinks to initiate sequences of downloads and interactions with web sites and network servers containing malicious software. Enterprise security groups were well poised and experienced in defending the former attacks, but the new types of attacks were larger in number, more challenging to detect, dynamic in nature, and required the development of new technologies and analytic capabilities. The Hybrid LDRD project was aimed at delivering new capabilities in large-scale data modeling and analysis to enterprise security operators and analysts and understanding the challenges of detection and prevention of emerging cybersecurity threats. Leveraging previous LDRD research e orts and capabilities in large-scale relational data analysis, large-scale discrete data analysis and visualization, and streaming data analysis, new modeling and analysis capabilities were quickly brought to bear on the problems in email phishing and spear phishing attacks in the Sandia enterprise security operational groups at the onset of the Hybrid project. As part of this project, a software development and deployment framework was created within the security analyst work ow tool sets to facilitate the delivery and testing of new capabilities as they became available, and machine learning algorithms were developed to address the challenge of dynamic threats. Furthermore, researchers from the Hybrid project were embedded in the security analyst groups for almost a full year, engaged in daily operational activities and routines, creating an atmosphere of trust and collaboration between the researchers and security personnel. The Hybrid project has altered the way that research ideas can be incorporated into the production environments of Sandias enterprise security groups, reducing time to deployment from months and

  5. Active Ageing: An Analysis

    Directory of Open Access Journals (Sweden)

    Alina-Cristina Nuta

    2011-10-01

    Full Text Available The problem of ageing is a highly topical for Romania and for European Union. In this framework, to create and implement some strategies for active ageing is an important objective. The international and regional forums set (supported by official statistics that the number of older people growing rapidly. Romania needs some programmes (with labour, social, economic, health care aspects to deal with the demographic changes, programs that will reform the existing working life structures and legislation. Despite the actual pension reform, which tries to close the opportunity of early retirement (by penalizing the total pension flows, or increasing the retirement age, etc., the labour system does not sets some important targets for this area.

  6. Activating teaching methods, studying responses and learning

    OpenAIRE

    Christensen, Hans Peter; Vigild, Martin E.; Thomsen, Erik; Szabo, Peter; Horsewell, Andy

    2009-01-01

    Students’ study strategies when exposed to activating teaching methods are measured, analysed and compared to study strategies in more traditional lecture-based teaching. The resulting learning outcome is discussed. Peer Reviewed

  7. Social Activity Method (SAM): A Fractal Language for Mathematics

    Science.gov (United States)

    Dowling, Paul

    2013-01-01

    In this paper I shall present and develop my organisational language, "social activity method" (SAM), and illustrate some of its applications. I shall introduce a new scheme for "modes of recontextualisation" that enables the analysis of the ways in which one activity--which might be school mathematics or social research or any…

  8. Stability analysis of fractional-order generalized chaotic susceptible–infected–recovered epidemic model and its synchronization using active control method

    Indian Academy of Sciences (India)

    Sana P Ansari; Saurabh K Agrawal; Subir Das

    2015-01-01

    This paper presents the synchronization between a pair of identical susceptible–infected–recovered (SIR) epidemic chaotic systems and fractional-order time derivative using active control method. The fractional derivative is described in Caputo sense. Numerical simulation results show that the method is effective and reliable for synchronizing the fractional-order chaotic systems while it allows the system to remain in chaotic state. The striking features of this paper are: the successful presentation of the stability of the equilibrium state and the revelation that time for synchronization varies with the variation in fractional-order derivatives close to the standard one for different specified values of the parameters of the system.

  9. Optimization methods for activities selection problems

    Science.gov (United States)

    Mahad, Nor Faradilah; Alias, Suriana; Yaakop, Siti Zulaika; Arshad, Norul Amanina Mohd; Mazni, Elis Sofia

    2017-08-01

    Co-curriculum activities must be joined by every student in Malaysia and these activities bring a lot of benefits to the students. By joining these activities, the students can learn about the time management and they can developing many useful skills. This project focuses on the selection of co-curriculum activities in secondary school using the optimization methods which are the Analytic Hierarchy Process (AHP) and Zero-One Goal Programming (ZOGP). A secondary school in Negeri Sembilan, Malaysia was chosen as a case study. A set of questionnaires were distributed randomly to calculate the weighted for each activity based on the 3 chosen criteria which are soft skills, interesting activities and performances. The weighted was calculated by using AHP and the results showed that the most important criteria is soft skills. Then, the ZOGP model will be analyzed by using LINGO Software version 15.0. There are two priorities to be considered. The first priority which is to minimize the budget for the activities is achieved since the total budget can be reduced by RM233.00. Therefore, the total budget to implement the selected activities is RM11,195.00. The second priority which is to select the co-curriculum activities is also achieved. The results showed that 9 out of 15 activities were selected. Thus, it can concluded that AHP and ZOGP approach can be used as the optimization methods for activities selection problem.

  10. INTER-COUNTRY EFFICIENCY EVALUATION IN INNOVATION ACTIVITY ON THE BASIS OF METHOD FOR DATA ENVELOPMENT ANALYSIS AMONG COUNTRIES WITH DEVELOPED AND DEVELOPING ECONOMY, INCLUDING THE REPUBLIC OF BELARUS

    Directory of Open Access Journals (Sweden)

    I. V. Zhukovski

    2016-01-01

    Full Text Available The paper considers a problem on efficiency evaluation of innovation activity in 63 countries with developed and developing economies while using a method for data envelopment analysis. The following results of innovation activity have been used for calculation of an efficiency factor: export of high-technology products as percentage of industrial product export, export of ICT services as percentage of services export and payments obtained due to realization of intellectual property rights (in US dollars. A model of the data envelopment analysis with a changeable scale-dependent effect and which is directed on maximization of the obtained results (output-oriented VRS model has been used for the analysis. The evaluation has shown that such countries as the USA, Israel, Sweden and some others have maximum efficiency of resource transformation into innovative activity output. The executed analysis has revealed that the Republic of Belarus has a potential for improvement of indices on innovation results.

  11. The influence of friends and psychosocial factors on physical activity and screen time behavior in adolescents: a mixed-methods analysis.

    Science.gov (United States)

    Garcia, Jeanette M; Sirard, John R; Deutsch, Nancy L; Weltman, Arthur

    2016-08-01

    (1) Determine the association between adolescent moderate-to-vigorous physical activity (MVPA) and screen time with their nominated friends' behaviors and (2) explore potential mechanisms of friends' social influences on MVPA and screen time. Participants consisted of 152 adolescents (mean age: 14.5 years, 53 % female, 50 % high school, 80 % Caucasian). MVPA was measured with an Actigraph GT3X+ accelerometer. Demographic and psychosocial variables were assessed via questionnaires. Participants nominated up to 5 friends who completed MVPA and screen time questionnaires. A subset of adolescents (n = 108) participated in focus groups that examined potential mechanism of friends' influence on MVPA and screen time. Multiple regression analysis examined the association of demographic, psychological, and nominated friend variables with participants' MVPA and screen time. NVivo 10.0 was used to analyze qualitative data. Greater levels of friends' MVPA was associated with greater levels of MVPA in both males (p associated with greater levels of screen time in males (p = .04) while psychosocial variables, such as increased screen time enjoyment, were associated with increased screen time in females (p = .01). School level was not associated with either MVPA or screen time. Focus group data indicated that friends positively influenced participants' MVPA through engaging in activity with participants, verbal encouragement, and modeling of MVPA. All participants preferred to be active with friends rather than alone, however, females preferred activity with a close friend while males preferred to be active with a group. Enjoyment of MVPA was the most cited reason for engaging in MVPA with friends. The majority of participants reported friends not having an influence on screen time. Adolescents with active friends are more likely to be physically active and spend less time engaging in screen-based behaviors. Interventions to increase MVPA in youth could be designed to

  12. Use of the Taguchi method for biomechanical comparison of flexor-tendon-repair techniques to allow immediate active flexion. A new method of analysis and optimization of technique to improve the quality of the repair.

    Science.gov (United States)

    Singer, G; Ebramzadeh, E; Jones, N F; Meals, R

    1998-10-01

    The current trend toward early active flexion after repair of the flexor tendons necessitates a stronger repair than that provided by a modified Kessler technique with use of 4-0 nylon suture. The purpose of the current study was to determine, with use of the Taguchi method of analysis, the strongest and most consistent repair of the flexor tendons. Flexor tendons were obtained from fresh-frozen hands of human cadavera. Eight flexor tendons initially were repaired with the modified Kessler technique with use of 4-0 nylon core suture and 6-0 nylon epitenon suture. A test matrix was used to analyze a total of twenty variables in sixty-four tests. These variables included eight techniques for core-suture repair, four types of core suture, two sizes of core suture, four techniques for suture of the epitenon, and two distances from the repair site for placement of the core suture. After each repair, the specimens were mounted in a servohydraulic mechanical testing machine for tension-testing to failure. The optimum combination of variables was determined, with the Taguchi method, to be an augmented Becker technique with use of 3-0 Mersilene core suture, placed 0.75 centimeter from the cut edge with volar epitenon suture. The four-strand, double modified Kessler technique provided the second strongest repair. Five tendons that had been repaired with use of the optimum combination then were tested and compared with tendons that had been repaired with the standard modified Kessler technique. With the optimum combination of variables, the strength of the repair improved from a mean (and standard deviation) of 17.2 +/- 2.9 to 128 +/- 5.6 newtons, and the stiffness improved from a mean of 4.6 to 16.2 newtons per millimeter.

  13. A Novel Method for Real-Time, Continuous, Fluorescence-Based Analysis of Anti-DNA Abzyme Activity in Systemic Lupus

    Directory of Open Access Journals (Sweden)

    Michelle F. Cavallo

    2012-01-01

    Full Text Available Systemic Lupus Erythematosus (SLE is an autoimmune disease characterized by the production of antibodies against a variety of self-antigens including nucleic acids. These antibodies are cytotoxic, catalytic (hydrolyzing DNA, RNA, and protein, and nephritogenic. Current methods for investigating catalytic activities of natural abzymes produced by individuals suffering from autoimmunity are mostly discontinuous and often employ hazardous reagents. Here we demonstrate the utility of dual-labeled, fluorogenic DNA hydrolysis probes in highly specific, sensitive, continuous, fluorescence-based measurement of DNA hydrolytic activity of anti-ssDNA abzymes purified from the serum of patients suffering from SLE. An assay for the presence and levels of antibodies exhibiting hydrolytic activity could facilitate disease diagnosis, prediction of flares, monitoring of disease state, and response to therapy. The assay may allow indirect identification of additional targets of anti-DNA antibodies and the discovery of molecules that inhibit their activity. Combined, these approaches may provide new insights into molecular mechanisms of lupus pathogenesis.

  14. Faecal gas analysis by electronic nose as novel, non-invasive method for assessment of active and quiescent paediatric inflammatory bowel disease: Proof of principle study.

    Science.gov (United States)

    de Meij, Tim G J; de Boer, Nanne K H; Benninga, Marc A; Lentferink, Yvette E; de Groot, Evelien F J; van de Velde, Mirjam E; van Bodegraven, Adriaan A; van der Schee, Marc P

    2014-09-22

    Inflammatory bowel disease (IBD) and its two phenotypes ulcerative colitis (UC) and Crohn's disease (CD) are essentially assessed by endoscopy, both in initial diagnostic work-up and during follow-up. This carries a high burden, especially on paediatric patients. Faecal volatile organic compounds (VOCs) are considered potential non-invasive biomarkers for intestinal diseases linked to gut microbiota alterations. We hypothesized that faecal VOC analysis by electronic nose allows discrimination of children with CD, UC and controls during active disease and remission. Faecal VOC patterns of children with newly diagnosed IBD and controls were studied by an electronic nose (Cyranose 320®), at baseline and upon achieving remission at 6-weeks of follow-up. Disease activity was assessed by global physician's assessment, substantiated by serum C-reactive protein and faecal calprotectin. Internally cross-validated receiver-operator-characteristic curves and corresponding sensitivity and specificity for detection of IBD were calculated RESULTS: Faecal VOC profiles of patients with UC (26) and CD (29) differed from controls (28); in active disease (AUC±95% CI, p-value, sensitivity, specificity: 1.00±0.00; p<0.001, 100%, 100%) and (0.85±0.05, p<0.001, 86%, 67%) and in clinical remission (0.94±0.06, p<0.001, 94%, 94%) and (0.94±0.06, p<0.001, 94%, 94%), respectively. Furthermore, CD-patients differed from UC-patients during active disease (0.96±0.03; p<0.001, 97%, 92%), and upon achieving clinical remission (0.81±0.08, p=0.002, 88%, 72%). Faecal VOC analysis allowed discrimination of paediatric patients with IBD from controls, both during active disease and remission. It therefore has potential as non-invasive test, in both diagnostic work-up and assessment of disease activity in IBD. Copyright © 2014 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

  15. Analysis and estimation of risk management methods

    Directory of Open Access Journals (Sweden)

    Kankhva Vadim Sergeevich

    2016-05-01

    Full Text Available At the present time risk management is an integral part of state policy in all the countries with developed market economy. Companies dealing with consulting services and implementation of the risk management systems carve out a niche. Unfortunately, conscious preventive risk management in Russia is still far from the level of standardized process of a construction company activity, which often leads to scandals and disapproval in case of unprofessional implementation of projects. The authors present the results of the investigation of the modern understanding of the existing methodology classification and offer the authorial concept of classification matrix of risk management methods. Creation of the developed matrix is based on the analysis of the method in the context of incoming and outgoing transformed information, which may include different elements of risk control stages. So the offered approach allows analyzing the possibilities of each method.

  16. A new and fast DLLME-CE method for the enantioselective analysis of zopiclone and its active metabolite after fungal biotransformation.

    Science.gov (United States)

    de Albuquerque, Nayara Cristina Perez; de Gaitani, Cristiane Masetto; de Oliveira, Anderson Rodrigo Moraes

    2015-05-10

    Zopiclone (ZO) is a chiral drug that undergoes extensive metabolism to N-desmethylzopiclone (N-Des-ZO) and zopiclone-N-oxide (N-Ox-ZO). Pharmacological studies have shown (S)-N-Des-ZO metabolite presents anxiolytic activity and a patent for this metabolite was requested for anxiety treatment and related disorders. In this context, biotransformation employing fungi may be a promising strategy to obtain N-Des-ZO. To perform the biotransformation study in this work, an enantioselective method based on capillary electrophoresis (CE) and dispersive liquid-liquid microextraction (DLLME) was developed. CE analyses were carried out in sodium phosphate buffer (pH 2.5; 50mmolL(-1)) containing 0.5% (w/v) carboxymethyl-β-CD, at a constant voltage of +25kV. DLLME was conducted using 2mL of liquid culture medium pH 9.5. Chloroform (100μL) and methanol (300μL) were employed as extraction and disperser solvent, respectively. After CE and DLLME optimization, the analytical method was fully validated. The method was linear over a concentration range of 90-6000ngmL(-1) for each ZO enantiomer (r>0.999) and 50-1000ngmL(-1) for each N-Des-ZO enantiomer (r>0.998). Absolute recovery of 51 and 82% was achieved for N-Des-ZO and ZO, respectively. The accuracy and precision results agreed with the EMA (European Medicines Agency) guideline, and so did the stability study. Application of the developed method in a biotransformation study was conducted in order to investigate the ability of fungi, belonging to the genus Cunninghamella, in metabolizing ZO chiral drug. Fungi Cunninghamella elegans ATCC 10028B and Cunninghamella echinulata var elegans ATCC 8688A demonstrated to be able to enantioselectively biotransform ZO to its active metabolite, N-Des-ZO. Therefore, the proposed goals of this work, i.e. a fast DLLME-CE method and an outstanding strategy to obtain N-Des-ZO, were successfully attained.

  17. Methods for using polypeptides having cellobiohydrolase activity

    Energy Technology Data Exchange (ETDEWEB)

    Morant, Marc D; Harris, Paul

    2016-08-23

    The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

  18. Simultaneous quantitation of 14 active components in Yinchenhao decoction with an ultrahigh performance liquid chromatography-diode array detector: Method development and ingredient analysis of different commonly prepared samples.

    Science.gov (United States)

    Yi, YaXiong; Zhang, Yong; Ding, Yue; Lu, Lu; Zhang, Tong; Zhao, Yuan; Xu, XiaoJun; Zhang, YuXin

    2016-11-01

    J. Sep. Sci. 2016, 39, 4147-4157 DOI: 10.1002/jssc.201600284 Yinchenhao decoction (YCHD) is a famous Chinese herbal formula recorded in the Shang Han Lun which was prescribed by Zhongjing Zhang during 150-219 AD. A novel quantitative analysis method was developed, based on ultrahigh performance liquid chromatography coupled with a diode array detector for the simultaneous determination of 14 main active components in Yinchenhao decoction. Furthermore, the method has been applied for compositional difference analysis of the 14 components in eight normal extraction samples of Yinchenhao decoction, with the aid of hierarchical clustering analysis and similarity analysis. The present research could help hospital, factory and lab choose the best way to make Yinchenhao decoction with better efficacy.

  19. Activity Analysis and Cost Analysis in Medical Schools.

    Science.gov (United States)

    Koehler, John E.; Slighton, Robert L.

    There is no unique answer to the question of what an ongoing program costs in medical schools. The estimates of program costs generated by classical methods of cost accounting are unsatisfactory because such accounting cannot deal with the joint production or joint cost problem. Activity analysis models aim at calculating the impact of alternative…

  20. Rapid coal proximate analysis by thermogravimetric method

    Energy Technology Data Exchange (ETDEWEB)

    Mao Jianxiong; Yang Dezhong; Zhao Baozhong

    1987-09-01

    A rapid coal proximate analysis by thermogravimetric analysis (TGA) can be used as an alternative method for the standard proximate analysis. This paper presents a program set up to rapidly perform coal proximate analysis by using a thermal analyzer and TGA module. A comparison between coal proximate analyses by standard method (GB) and TGA is also given. It shows that most data from TGA fall within the tolerance limit of standard method.

  1. Evaluation of methods to assess physical activity

    Science.gov (United States)

    Leenders, Nicole Y. J. M.

    Epidemiological evidence has accumulated that demonstrates that the amount of physical activity-related energy expenditure during a week reduces the incidence of cardiovascular disease, diabetes, obesity, and all-cause mortality. To further understand the amount of daily physical activity and related energy expenditure that are necessary to maintain or improve the functional health status and quality of life, instruments that estimate total (TDEE) and physical activity-related energy expenditure (PAEE) under free-living conditions should be determined to be valid and reliable. Without evaluation of the various methods that estimate TDEE and PAEE with the doubly labeled water (DLW) method in females there will be eventual significant limitations on assessing the efficacy of physical activity interventions on health status in this population. A triaxial accelerometer (Tritrac-R3D, (TT)), an uniaxial (Computer Science and Applications Inc., (CSA)) activity monitor, a Yamax-Digiwalker-500sp°ler , (YX-stepcounter), by measuring heart rate responses (HR method) and a 7-d Physical Activity Recall questionnaire (7-d PAR) were compared with the "criterion method" of DLW during a 7-d period in female adults. The DLW-TDEE was underestimated on average 9, 11 and 15% using 7-d PAR, HR method and TT. The underestimation of DLW-PAEE by 7-d PAR was 21% compared to 47% and 67% for TT and YX-stepcounter. Approximately 56% of the variance in DLW-PAEE*kgsp{-1} is explained by the registration of body movement with accelerometry. A larger proportion of the variance in DLW-PAEE*kgsp{-1} was explained by jointly incorporating information from the vertical and horizontal movement measured with the CSA and Tritrac-R3D (rsp2 = 0.87). Although only a small amount of variance in DLW-PAEE*kgsp{-1} is explained by the number of steps taken per day, because of its low cost and ease of use, the Yamax-stepcounter is useful in studies promoting daily walking. Thus, studies involving the

  2. A catalog of automated analysis methods for enterprise models.

    Science.gov (United States)

    Florez, Hector; Sánchez, Mario; Villalobos, Jorge

    2016-01-01

    Enterprise models are created for documenting and communicating the structure and state of Business and Information Technologies elements of an enterprise. After models are completed, they are mainly used to support analysis. Model analysis is an activity typically based on human skills and due to the size and complexity of the models, this process can be complicated and omissions or miscalculations are very likely. This situation has fostered the research of automated analysis methods, for supporting analysts in enterprise analysis processes. By reviewing the literature, we found several analysis methods; nevertheless, they are based on specific situations and different metamodels; then, some analysis methods might not be applicable to all enterprise models. This paper presents the work of compilation (literature review), classification, structuring, and characterization of automated analysis methods for enterprise models, expressing them in a standardized modeling language. In addition, we have implemented the analysis methods in our modeling tool.

  3. Probabilistic methods in combinatorial analysis

    CERN Document Server

    Sachkov, Vladimir N

    2014-01-01

    This 1997 work explores the role of probabilistic methods for solving combinatorial problems. These methods not only provide the means of efficiently using such notions as characteristic and generating functions, the moment method and so on but also let us use the powerful technique of limit theorems. The basic objects under investigation are nonnegative matrices, partitions and mappings of finite sets, with special emphasis on permutations and graphs, and equivalence classes specified on sequences of finite length consisting of elements of partially ordered sets; these specify the probabilist

  4. Optimization Methods for Supply Chain Activities

    Directory of Open Access Journals (Sweden)

    Balasescu S.

    2014-12-01

    Full Text Available This paper approach the theme of supply chain activities for medium and large companies which run many operations and need many facilities. The first goal is to analyse the influence of optimisation methods of supply chain activities on the success rate for a business. The second goal is to compare some logistic strategies applied by companies with the same profile to see which is the most effective. The final goal is to show which is the necessity of strategic optimum for a company and how can be achieved the considering the demand uncertainty.

  5. Convergence analysis of combinations of different methods

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Y. [Clarkson Univ., Potsdam, NY (United States)

    1994-12-31

    This paper provides a convergence analysis for combinations of different numerical methods for solving systems of differential equations. The author proves that combinations of two convergent linear multistep methods or Runge-Kutta methods produce a new convergent method of which the order is equal to the smaller order of the two original methods.

  6. SWOT ANALYSIS ON SAMPLING METHOD

    National Research Council Canada - National Science Library

    CHIS ANCA OANA; BELENESI MARIOARA;

    2014-01-01

    .... Our article aims to study audit sampling in audit of financial statements. As an audit technique largely used, in both its statistical and nonstatistical form, the method is very important for auditors...

  7. Prognostic Analysis System and Methods of Operation

    Science.gov (United States)

    MacKey, Ryan M. E. (Inventor); Sneddon, Robert (Inventor)

    2014-01-01

    A prognostic analysis system and methods of operating the system are provided. In particular, a prognostic analysis system for the analysis of physical system health applicable to mechanical, electrical, chemical and optical systems and methods of operating the system are described herein.

  8. Anti-inflammatory activity and qualitative analysis of different extracts of Maytenus obscura (A. Rich.) Cuf. by high performance thin layer chromatography method

    Institute of Scientific and Technical Information of China (English)

    Mohamed F. Alajmi; Perwez Alam

    2014-01-01

    Objective: To perform aqueous ethanol soluble fraction (AESF) and dichloromethane extract of aerial parts of Maytenus obscura (A. Rich.) Cuf. using high performance thin layer chromatography (HPTLC) and to test anti-inflammatory activity of these extracts.Methods:HPTLC studies were carried out using CAMAG HPTLC system equipped with Linomat IV applicator, TLC scanner 3, Reprostar 3, CAMAG ADC 2 and WIN CATS-4 software were used. The anti-inflammatory activity was tested by injecting different groups of rats (6 each) with formalin in hind paw and measuring the edema volume before and 1 h later formalin injection. Control group received saline i.p. The extracts treatment was injected i.p. in doses of 100 and 200 mg/kg 1 h before formalin administration. Indomethacin (30 mg/kg) was used as standard.Results:The results of preliminary phytochemical studies confirmed the presence of protein, lipid, carbohydrate, phenol, flavonoid, saponin, triterpenoid, alkaloid and anthraquinone in both extracts. Chromatography was performed on glass-backed silica gel 60 F254 HPTLC plates with the green solvents toluene: ethyacetate: glacial acetic acid (5:3:0.2, v/v/v) as mobile phase. HPTLC finger printing of AESF revealed major eight peaks with Rf values in the range of 0.28 to 0.80 and the dichloromethane revealed major 11 peaks with Rf values in the range of 0.12 to 0.76. The purity of sample was confirmed by comparing the absorption spectra at start, middle and end position of the band. Treatment of rats (i.p.) with AESF and dichloromethane in doses of 100 and 200 mg/kg inhibited singnificantly (P<0.05, n=6) formalin-induced inflammation by 50%, 55.9%, 45.5%, and 51.4%, respectively.Conclusions:HPTLC finger printing of AESF and dichloromethane of Maytenus obscura revealed eight major spots for alcoholic extracts and nine major spots for dichloromethane extracts. These HPTLC profiles may be of great usefulness in the quality control of herbal products containing these extracts. The

  9. Applying critical analysis - main methods

    Directory of Open Access Journals (Sweden)

    Miguel Araujo Alonso

    2012-02-01

    Full Text Available What is the usefulness of critical appraisal of literature? Critical analysis is a fundamental condition for the correct interpretation of any study that is subject to review. In epidemiology, in order to learn how to read a publication, we must be able to analyze it critically. Critical analysis allows us to check whether a study fulfills certain previously established methodological inclusion and exclusion criteria. This is frequently used in conducting systematic reviews although eligibility criteria are generally limited to the study design. Critical analysis of literature and be done implicitly while reading an article, as in reading for personal interest, or can be conducted in a structured manner, using explicit and previously established criteria. The latter is done when formally reviewing a topic.

  10. [Bioluminescent method of determining antiprotease activity].

    Science.gov (United States)

    Gitel'zon, I I; Rykov, S A; Kratasiuk, G A; Petushkov, V N; Shvetskiĭ, A G

    1985-11-01

    A method for antiprotease activity measurement based on the use of luminous bacteria luciferase as protein substrate of proteases is suggested. Antiprotease is incubated with protease for 1 to 2 min at 30 degrees C and then it is added to the reaction mixture containing luciferase, NADH: FMN-oxidoreductase and their substrates--myristic aldehyde, FMN and NADH. Biofluorescence is measured in a temperature-controlled cuvette for 1 min. The total time of the measurement is 3 min. The method can be applied both in fine biochemical assays and in medical rapid diagnosis.

  11. Trial Sequential Methods for Meta-Analysis

    Science.gov (United States)

    Kulinskaya, Elena; Wood, John

    2014-01-01

    Statistical methods for sequential meta-analysis have applications also for the design of new trials. Existing methods are based on group sequential methods developed for single trials and start with the calculation of a required information size. This works satisfactorily within the framework of fixed effects meta-analysis, but conceptual…

  12. Nonlinear structural analysis using integrated force method

    Indian Academy of Sciences (India)

    N R B Krishnam Raju; J Nagabhushanam

    2000-08-01

    Though the use of the integrated force method for linear investigations is well-recognised, no efforts were made to extend this method to nonlinear structural analysis. This paper presents the attempts to use this method for analysing nonlinear structures. General formulation of nonlinear structural analysis is given. Typically highly nonlinear bench-mark problems are considered. The characteristic matrices of the elements used in these problems are developed and later these structures are analysed. The results of the analysis are compared with the results of the displacement method. It has been demonstrated that the integrated force method is equally viable and efficient as compared to the displacement method.

  13. Cost Analysis: Methods and Realities.

    Science.gov (United States)

    Cummings, Martin M.

    1989-01-01

    Argues that librarians need to be concerned with cost analysis of library functions and services because, in the allocation of resources, decision makers will favor library managers who demonstrate understanding of the relationships between costs and productive outputs. Factors that should be included in a reliable scheme for cost accounting are…

  14. Method to produce catalytically active nanocomposite coatings

    Energy Technology Data Exchange (ETDEWEB)

    Erdemir, Ali; Eryilmaz, Osman Levent; Urgen, Mustafa; Kazmanli, Kursat

    2016-02-09

    A nanocomposite coating and method of making and using the coating. The nanocomposite coating is disposed on a base material, such as a metal or ceramic; and the nanocomposite consists essentially of a matrix of an alloy selected from the group of Cu, Ni, Pd, Pt and Re which are catalytically active for cracking of carbon bonds in oils and greases and a grain structure selected from the group of borides, carbides and nitrides.

  15. Activation analysis of meteorites. 3

    Energy Technology Data Exchange (ETDEWEB)

    Nagai, H.; Honda, M.; Sato, H. [Nihon Univ., College of Humanities and Sciences, Tokyo (Japan); Ebihara, M.; Oura, Y.; Setoguchi, M. [Tokyo Metropolitan Univ., Faculty of Science, Tokyo (Japan)

    2001-07-01

    A long-lived cosmogenic nuclide, {sup 53}Mn in extra-terrestrial materials has been determined in the DR-1 hole of the JRR-3M reactor, applying the well-thermalized neutron flux. The neutron flux intensities are variable with the depths whereas the fast thermal ratios are not quite variable. By this method, {sup 53}Mn contents in iron meteorites and metal phases in general could be routinely determined in many samples. The chemical separation method has been modified and a convenient short circuit method has been proposed to shorten the process. The short method is to count the activities of {sup 54}Mn just after the irradiation without further purification of manganese. (author)

  16. Simultaneous quantitation of 14 active components in Yinchenhao decoction by using ultra high performance liquid chromatography with diode array detection: Method development and ingredient analysis of different commonly prepared samples.

    Science.gov (United States)

    Yi, YaXiong; Zhang, Yong; Ding, Yue; Lu, Lu; Zhang, Tong; Zhao, Yuan; Xu, XiaoJun; Zhang, YuXin

    2016-11-01

    We developed a novel quantitative analysis method based on ultra high performance liquid chromatography coupled with diode array detection for the simultaneous determination of the 14 main active components in Yinchenhao decoction. All components were separated on an Agilent SB-C18 column by using a gradient solvent system of acetonitrile/0.1% phosphoric acid solution at a flow rate of 0.4 mL/min for 35 min. Subsequently, linearity, precision, repeatability, and accuracy tests were implemented to validate the method. Furthermore, the method has been applied for compositional difference analysis of 14 components in eight normal-extraction Yinchenhao decoction samples, accompanied by hierarchical clustering analysis and similarity analysis. The result that all samples were divided into three groups based on different contents of components demonstrated that extraction methods of decocting, refluxing, ultrasonication and extraction solvents of water or ethanol affected component differentiation, and should be related to its clinical applications. The results also indicated that the sample prepared by patients in the family by using water extraction employing a casserole was almost same to that prepared using a stainless-steel kettle, which is mostly used in pharmaceutical factories. This research would help patients to select the best and most convenient method for preparing Yinchenhao decoction.

  17. Quantitative Method of Measuring Metastatic Activity

    Science.gov (United States)

    Morrison, Dennis R. (Inventor)

    1999-01-01

    The metastatic potential of tumors can be evaluated by the quantitative detection of urokinase and DNA. The cell sample selected for examination is analyzed for the presence of high levels of urokinase and abnormal DNA using analytical flow cytometry and digital image analysis. Other factors such as membrane associated uroldnase, increased DNA synthesis rates and certain receptors can be used in the method for detection of potentially invasive tumors.

  18. [Biliary, renal and fecal elimination and distribution of gold after a single oral administration of auranofin, quantified by the instrumental neutron activation analysis method].

    Science.gov (United States)

    Benn, H P; Schnier, C; Bauer, E; Seiler, K U; Elhöft, H; Löffler, H

    1991-01-01

    Three days after cholecystectomy, seven patients received a single dose of auranofin (5 tablets Ridaura = 4.35 mg gold). At defined time points thereafter the gold content in samples of blood, plasma, urine, bile, and feces was determined by instrumental neutron activation analysis (INAA). Maxima of the mean gold concentrations in blood (140 +/- 42 ng/ml) and plasma (173 +/- 54 ng/ml) are found 2 h after oral administration of the antirheumatic agent, after 16 h in urine (43 +/- 28 ng/ml) and bile (65 +/- 50 ng/ml), and after 24 h in erythrocytes (greater than 200 ng/ml). The mean terminal half-lives are 7.6 days (blood), 15 days (plasma), 5 days (erythrocytes), and 6.5 days (bile). The cumulative biliary gold excretion within 8 days after the administration of auranofin was 1.6%, compared with 4% and 40% for renal and fecal elimination, respectively. The gold concentration in plasma is always higher than that in bile. There is a close correlation between the areas under the concentration curves (AUC) in bile and plasma (r = 0.864).

  19. Physical Activity Measurement Accuracy in Individuals With Chronic Lung Disease: A Systematic Review With Meta-Analysis of Method Comparison Studies.

    Science.gov (United States)

    Dhillon, Satvir S; Sima, Carmen A; Kirkham, Ashley R; Syed, Nafeez; Camp, Pat G

    2015-11-01

    To investigate the accuracy of physical activity measurement strategies in adults with chronic lung disease. MEDLINE, Embase, and CINAHL databases were searched from inception to September 30, 2014. Studies reporting validity data for devices measuring energy expenditure in comparison with indirect calorimetry or doubly labeled water measurements in chronic lung disease were included. Nine publications in chronic obstructive pulmonary disease (COPD) or cystic fibrosis (CF) from 2294 studies were identified. Two reviewers evaluated studies for quality using a modified version of the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) checklist and extracted data relating to population, setting, devices, activity protocols, and energy expenditure. Disagreements were resolved by consensus. Studies were of high quality, with 8 studies scoring at least 9 out of 11 on the QUADAS checklist. In laboratory-based settings, the SenseWear multisensor accurately estimated energy expenditure during walking compared with indirect calorimetry (pooled mean difference, -0.7 kcal/min; 95% confidence interval [CI], -2.5 to 1.1) in COPD, but overestimated it in CF. However, 2 studies in COPD and CF showed the SenseWear multisensor accurately estimated energy expenditure during lifestyle tasks compared with indirect calorimetry (pooled mean difference, .18 kcal/min; 95% CI, -.13 to .49). The Digi-Walker pedometer underestimated energy expenditure compared with indirect calorimetry in COPD (mean difference walking, -2.4 kcal/min; 95% CI -3.4 to -1.1; mean difference lifestyle tasks, -2.3 kcal/min; 95% CI, -2.8 to -1.8). In free-living settings, the ActiReg multisensor accurately measured energy expenditure in COPD (mean difference, -21 kcal/d; 95% CI, -133.9 to 91.9), whereas the Flex Heart Rate Method underestimated energy expenditure in CF (mean difference, -454.1 kcal/d; 95% CI, -727 to -181.2). Energy expenditure estimation was accurate from the SenseWear and Acti

  20. Scoring methods used in cluster analysis

    OpenAIRE

    Sirota, Sergej

    2014-01-01

    The aim of the thesis is to compare methods of cluster analysis correctly classify objects in the dataset into groups, which are known. In the theoretical section first describes the steps needed to prepare a data file for cluster analysis. The next theoretical section is dedicated to the cluster analysis, which describes ways of measuring similarity of objects and clusters, and dedicated to description the methods of cluster analysis used in practical part of this thesis. In practical part a...

  1. The Functional Methods of Discourse Analysis

    Institute of Scientific and Technical Information of China (English)

    覃卓敏

    2008-01-01

    From the macroscopic angle of function, methods of discourse analysis are clarified to find out two important methods in pragmatics and through which will better used in the understanding of discourse.

  2. Infinitesimal methods of mathematical analysis

    CERN Document Server

    Pinto, J S

    2004-01-01

    This modern introduction to infinitesimal methods is a translation of the book Métodos Infinitesimais de Análise Matemática by José Sousa Pinto of the University of Aveiro, Portugal and is aimed at final year or graduate level students with a background in calculus. Surveying modern reformulations of the infinitesimal concept with a thoroughly comprehensive exposition of important and influential hyperreal numbers, the book includes previously unpublished material on the development of hyperfinite theory of Schwartz distributions and its application to generalised Fourier transforms and harmon

  3. Echinacea purpurea: Pharmacology, phytochemistry and analysis methods

    Directory of Open Access Journals (Sweden)

    Azadeh Manayi

    2015-01-01

    Full Text Available Echinacea purpurea (Asteraceae is a perennial medicinal herb with important immunostimulatory and anti-inflammatory properties, especially the alleviation of cold symptoms. The plant also attracted scientists′ attention to assess other aspects of its beneficial effects. For instance, antianxiety, antidepression, cytotoxicity, and antimutagenicity as induced by the plant have been revealed in various studies. The findings of the clinical trials are controversial in terms of side effects. While some studies revealed the beneficial effects of the plant on the patients and no severe adverse effects, some others have reported serious side effects including abdominal pain, angioedema, dyspnea, nausea, pruritus, rash, erythema, and urticaria. Other biological activities of the plant such as antioxidant, antibacterial, antiviral, and larvicidal activities have been reported in previous experimental studies. Different classes of secondary metabolites of the plant such as alkamides, caffeic acid derivatives, polysaccharides, and glycoproteins are believed to be biologically and pharmacologically active. Actually, concurrent determination and single analysis of cichoric acid and alkamides have been successfully developed mainly by using high-performance liquid chromatography (HPLC coupled with different detectors including UV spectrophotometric, coulometric electrochemical, and electrospray ionization mass spectrometric detectors. The results of the studies which were controversial revealed that in spite of major experiments successfully accomplished using E. purpurea, many questions remain unanswered and future investigations may aim for complete recognition of the plant′s mechanism of action using new, complementary methods.

  4. Echinacea purpurea: Pharmacology, phytochemistry and analysis methods.

    Science.gov (United States)

    Manayi, Azadeh; Vazirian, Mahdi; Saeidnia, Soodabeh

    2015-01-01

    Echinacea purpurea (Asteraceae) is a perennial medicinal herb with important immunostimulatory and anti-inflammatory properties, especially the alleviation of cold symptoms. The plant also attracted scientists' attention to assess other aspects of its beneficial effects. For instance, antianxiety, antidepression, cytotoxicity, and antimutagenicity as induced by the plant have been revealed in various studies. The findings of the clinical trials are controversial in terms of side effects. While some studies revealed the beneficial effects of the plant on the patients and no severe adverse effects, some others have reported serious side effects including abdominal pain, angioedema, dyspnea, nausea, pruritus, rash, erythema, and urticaria. Other biological activities of the plant such as antioxidant, antibacterial, antiviral, and larvicidal activities have been reported in previous experimental studies. Different classes of secondary metabolites of the plant such as alkamides, caffeic acid derivatives, polysaccharides, and glycoproteins are believed to be biologically and pharmacologically active. Actually, concurrent determination and single analysis of cichoric acid and alkamides have been successfully developed mainly by using high-performance liquid chromatography (HPLC) coupled with different detectors including UV spectrophotometric, coulometric electrochemical, and electrospray ionization mass spectrometric detectors. The results of the studies which were controversial revealed that in spite of major experiments successfully accomplished using E. purpurea, many questions remain unanswered and future investigations may aim for complete recognition of the plant's mechanism of action using new, complementary methods.

  5. Earth analysis methods, subsurface feature detection methods, earth analysis devices, and articles of manufacture

    Science.gov (United States)

    West, Phillip B [Idaho Falls, ID; Novascone, Stephen R [Idaho Falls, ID; Wright, Jerry P [Idaho Falls, ID

    2012-05-29

    Earth analysis methods, subsurface feature detection methods, earth analysis devices, and articles of manufacture are described. According to one embodiment, an earth analysis method includes engaging a device with the earth, analyzing the earth in a single substantially lineal direction using the device during the engaging, and providing information regarding a subsurface feature of the earth using the analysis.

  6. Earth analysis methods, subsurface feature detection methods, earth analysis devices, and articles of manufacture

    Science.gov (United States)

    West, Phillip B.; Novascone, Stephen R.; Wright, Jerry P.

    2011-09-27

    Earth analysis methods, subsurface feature detection methods, earth analysis devices, and articles of manufacture are described. According to one embodiment, an earth analysis method includes engaging a device with the earth, analyzing the earth in a single substantially lineal direction using the device during the engaging, and providing information regarding a subsurface feature of the earth using the analysis.

  7. Analysis methods for facial motion

    Directory of Open Access Journals (Sweden)

    Katsuaki Mishima

    2009-05-01

    Full Text Available Objective techniques to evaluate a facial movement are indispensable for the contemporary treatment of patients with motor disorders such as facial paralysis, cleft lip, postoperative head and neck cancer, and so on. Recently, computer-assisted, video-based techniques have been devised and reported as measuring systems in which facial movements can be evaluated quantitatively. Commercially available motion analysis systems, in which a stereo-measuring technique with multiple cameras and markers to facilitate search of matching among images through all cameras, also are utilized, and are used in many measuring systems such as video-based systems. The key is how the problems of facial movement can be extracted precisely, and how useful information for the diagnosis and decision-making process can be derived from analyses of facial movement. Therefore, it is important to discuss which facial animations should be examined, and whether fixation of the head and markers attached to the face can hamper natural facial movement.

  8. Optical Design and Active Optics Methods in Astronomy

    CERN Document Server

    Lemaitre, Gerard R

    2013-01-01

    Optical designs for astronomy involve implementation of active optics and adaptive optics from X-ray to the infrared. Developments and results of active optics methods for telescopes, spectrographs and coronagraph planet finders are presented. The high accuracy and remarkable smoothness of surfaces generated by active optics methods also allow elaborating new optical design types with high aspheric and/or non-axisymmetric surfaces. Depending on the goal and performance requested for a deformable optical surface analytical investigations are carried out with one of the various facets of elasticity theory: small deformation thin plate theory, large deformation thin plate theory, shallow spherical shell theory, weakly conical shell theory. The resulting thickness distribution and associated bending force boundaries can be refined further with finite element analysis. Keywords: active optics, optical design, elasticity theory, astronomical optics, diffractive optics, X-ray optics

  9. Probabilistic structural analysis by extremum methods

    Science.gov (United States)

    Nafday, Avinash M.

    1990-01-01

    The objective is to demonstrate discrete extremum methods of structural analysis as a tool for structural system reliability evaluation. Specifically, linear and multiobjective linear programming models for analysis of rigid plastic frames under proportional and multiparametric loadings, respectively, are considered. Kinematic and static approaches for analysis form a primal-dual pair in each of these models and have a polyhedral format. Duality relations link extreme points and hyperplanes of these polyhedra and lead naturally to dual methods for system reliability evaluation.

  10. Sensitivity Analysis Using Simple Additive Weighting Method

    Directory of Open Access Journals (Sweden)

    Wayne S. Goodridge

    2016-05-01

    Full Text Available The output of a multiple criteria decision method often has to be analyzed using some sensitivity analysis technique. The SAW MCDM method is commonly used in management sciences and there is a critical need for a robust approach to sensitivity analysis in the context that uncertain data is often present in decision models. Most of the sensitivity analysis techniques for the SAW method involve Monte Carlo simulation methods on the initial data. These methods are computationally intensive and often require complex software. In this paper, the SAW method is extended to include an objective function which makes it easy to analyze the influence of specific changes in certain criteria values thus making easy to perform sensitivity analysis.

  11. The method of apparel manufactures business process analysis based on activity-based costing%基于作业成本的服装企业业务过程分析方法

    Institute of Scientific and Technical Information of China (English)

    吴涛

    2012-01-01

    The business process analysis model is provided based on the operating costs. By analyzing garment enterprises,the production process is analysed. The method for export operating costs, operating and resource hierarchy from business process analysis model and business process model is also mentioned. The method of calculating operating costs is concluded,the activity-based costing is completed by using operating cost table.%提出基于作业成本的业务过程分析模型.以服装企业为例,分析了成衣生产流程.探讨从业务过程分析模型以及业务流程模型导出资源层次结构的方法.给出了作业成本的计算方法,利用其数据表完成作业成本计算.

  12. Antioxidant properties of Krebs cycle intermediates against malonate pro-oxidant activity in vitro: a comparative study using the colorimetric method and HPLC analysis to determine malondialdehyde in rat brain homogenates.

    Science.gov (United States)

    Puntel, Robson Luiz; Roos, Daniel Henrique; Grotto, Denise; Garcia, Solange C; Nogueira, Cristina Wayne; Rocha, Joao Batista Teixeira

    2007-06-13

    A variety of Krebs cycle intermediaries has been shown to possess antioxidant properties in different in vivo and in vitro systems. Here we examined whether citrate, succinate, malate, oxaloacetate, fumarate and alpha-ketoglutarate could modulate malonate-induced thiobarbituric acid-reactive species (TBARS) production in rat brain homogenate. The mechanisms involved in their antioxidant activity were also determined using two analytical methods: 1) a popular spectrophotometric method (Ohkawa, H., Ohishi, N., Yagi, K., 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry 95, 351-358.) and a high performance liquid chromatographic (HPLC) procedure (Grotto, D., Santa Maria, L. D., Boeira, S., Valentini, J., Charão, M. F., Moro, A. M., Nascimento, P. C., Pomblum, V. J., Garcia, S. C., 2006. Rapid quantification of malondialdehyde in plasma by high performance liquid chromatography-visible detection. Journal of Pharmaceutical and Biomedical Analysis 43, 619-624.). Citrate, malate, and oxaloacetate reduced both basal and malonate-induced TBARS production. Their effects were not changed by pre-treatment of rat brain homogenates at 100 degrees C for 10 min. alpha-Ketoglutarate increased basal TBARS without changing malonate-induced TBARS production in fresh and heat-treated homogenates. Succinate reduced basal--without altering malonate-induced TBARS production. Its antioxidant activity was abolished by KCN or heat treatment. Fumarate reduced malonate-induced TBARS production in fresh homogenates; however, its effect was completely abolished by heat treatment. There were minimal differences among the studied methods. Citrate, oxaloacetate, malate, alpha-ketoglutarate and malonate showed iron-chelating activity. We suggest that antioxidant properties of citrate, malate and oxaloacetate were due to their ability to cancel iron redox activity by forming inactive complexes, whereas alpha-ketoglutarate and malonate pro

  13. Constructing an Intelligent Patent Network Analysis Method

    Directory of Open Access Journals (Sweden)

    Chao-Chan Wu

    2012-11-01

    Full Text Available Patent network analysis, an advanced method of patent analysis, is a useful tool for technology management. This method visually displays all the relationships among the patents and enables the analysts to intuitively comprehend the overview of a set of patents in the field of the technology being studied. Although patent network analysis possesses relative advantages different from traditional methods of patent analysis, it is subject to several crucial limitations. To overcome the drawbacks of the current method, this study proposes a novel patent analysis method, called the intelligent patent network analysis method, to make a visual network with great precision. Based on artificial intelligence techniques, the proposed method provides an automated procedure for searching patent documents, extracting patent keywords, and determining the weight of each patent keyword in order to generate a sophisticated visualization of the patent network. This study proposes a detailed procedure for generating an intelligent patent network that is helpful for improving the efficiency and quality of patent analysis. Furthermore, patents in the field of Carbon Nanotube Backlight Unit (CNT-BLU were analyzed to verify the utility of the proposed method.

  14. Matrix methods for bare resonator eigenvalue analysis.

    Science.gov (United States)

    Latham, W P; Dente, G C

    1980-05-15

    Bare resonator eigenvalues have traditionally been calculated using Fox and Li iterative techniques or the Prony method presented by Siegman and Miller. A theoretical framework for bare resonator eigenvalue analysis is presented. Several new methods are given and compared with the Prony method.

  15. Text analysis methods, text analysis apparatuses, and articles of manufacture

    Science.gov (United States)

    Whitney, Paul D; Willse, Alan R; Lopresti, Charles A; White, Amanda M

    2014-10-28

    Text analysis methods, text analysis apparatuses, and articles of manufacture are described according to some aspects. In one aspect, a text analysis method includes accessing information indicative of data content of a collection of text comprising a plurality of different topics, using a computing device, analyzing the information indicative of the data content, and using results of the analysis, identifying a presence of a new topic in the collection of text.

  16. Methods of marketing and advertising activity evaluation

    Directory of Open Access Journals (Sweden)

    A.I. Yakovlev

    2016-09-01

    Full Text Available The result of the business entities’ activities is associated with the development of instruments of the economic processes efficiency determination, including marketing activities. It has determined the purpose of the article. The methodological principles in this area are developed. It is proved that the increase in sales of the profit margin is only partly dependent on the implementation of advertising measures. The methodical approaches for estimation of exhibition and advertising activity and promotion of its employees are specified. The results of work involve evaluation of the advertising effect value on the basis of share of the advertising impact on the increase of sales and revenue from the sale of products. The corresponding proportion of such impact is determined based on the consumer inquiry. The index of trade fair works, its calculation based on two components: how many times a specific company participated in such events; and how well the company was presented at relevant trade fairs. The indices of the cost on advertising and promotion of certain products manufacturer are provided. The scientific innovation of the research is as follows. It is proved that the sales increase effect should not be assigned to advertising only. The compositions that influence the consumer preferences and their share in the total value effect are determined. The new is the proposed index of influence of the trade fair work results depending on the selected factors. The practical importance of the research results involve more accurate calculation of the effect of the activities made and, consequently, increase efficiency of the business entities.

  17. [Novel mathematical approach to determination of antibiotics concentration by agar diffusion method. Analysis of graphical, table and mathematical options of relative biological activity estimation].

    Science.gov (United States)

    Esipov, S E

    1998-01-01

    Several varieties of relative biological activity estimation are comparatively analyzed and illustrated by an example of tylosin. For visual demonstration the estimates with the equation of a straight line are represented graphically. It is concluded that the design equations in the State Pharmacopeia XI (USSR) should be respectively replaced. The advantages of the variety for the biological activity estimation with the one-point intercept form of the equation of a straight line are illustrated by particular examples.

  18. Anti–inflammatory activity and qualitative analysis of different extracts of Maytenus obscura (A. Rich. Cuf. by high performance thin layer chromatography method

    Directory of Open Access Journals (Sweden)

    Mohamed F. Alajmi

    2014-02-01

    Conclusions: HPTLC finger printing of AESF and dichloromethane of Maytenus obscura revealed eight major spots for alcoholic extracts and nine major spots for dichloromethane extracts. These HPTLC profiles may be of great usefulness in the quality control of herbal products containing these extracts. The anti-inflammatory activity of both extracts also revealed the medicinal importance of these extracts. The plant can be further explored for the isolation of phytoconstituents having anti-inflammatory activity.

  19. Analysis of Maths Learning Activities Developed By Pre-service Teachers in Terms of the Components of Content, Purpose, Application Methods

    Directory of Open Access Journals (Sweden)

    Çağla Toprak

    2014-04-01

    Full Text Available Today- when the influence of the alteration movement done in order to keep up with the age of the educational system is still continuing- the importance of teachers in students’ learning and achieving what is expected from the education system has been stated by the studies conducted (Hazır & Bıkmaz, 2006. Teachers own a critical role in the stage of both preparing teaching materials and using them (Stein & Smith, 1998b; Swan, 2007. When the existing curriculums –in particular, maths and geometry cirriculums- are analyzed, it can be observed that activities are the most significant teaching materials (Bozkurt, 2012. In fact, it is possible to characterize the existing curriculums as activity-based ones (Report of Workshop Examining Content of Primary School Curriculums According to Branches, 2010; Epö, 2005. Therefore, what sort of learning activities there are, what qualities they need to have, how to design and apply them are topics that must be elaborated (Uğurel et al., 2010.  At this point, our study to increase the skills of pre-service teachers during the process of developing activities was conducted with 27 pre-service teachers -19 girls 8 boys- studying in the 4th year in Mathematics Education Department at a state university in the Aegean Region. The activity designs the pre-service teachers developed considering the patterns given after a series of practice were analyzed in documents in terms of the aim of design and the form of practice. As a result of the studies, it is observed that pre-service teachers deal with the topics from the maths curriculum and these topics are of different grade levels. The result of the examination named as target component suggests that activities developed aim firstly at providing learning and this is followed by reinforcing the concepts already learned. It is stated that pre-service teachers prefer mostly small group (cooperative studies in the activities they develop.Key Words:

  20. Parametric Methods for Order Tracking Analysis

    DEFF Research Database (Denmark)

    Jensen, Tobias Lindstrøm; Nielsen, Jesper Kjær

    2017-01-01

    Order tracking analysis is often used to find the critical speeds at which structural resonances are excited by a rotating machine. Typically, order tracking analysis is performed via non-parametric methods. In this report, however, we demonstrate some of the advantages of using a parametric method...... for order tracking analysis. Specifically, we show that we get a much better time and frequency resolution, obtain a much more robust and accurate estimate of the RPM profile, and are able to perform accurate order tracking analysis even without the tachometer signal....

  1. ACTIVE AND PARTICIPATORY METHODS IN BIOLOGY: MODELING

    Directory of Open Access Journals (Sweden)

    Brînduşa-Antonela SBÎRCEA

    2011-01-01

    Full Text Available By using active and participatory methods it is hoped that pupils will not only come to a deeper understanding of the issues involved, but also that their motivation will be heightened. Pupil involvement in their learning is essential. Moreover, by using a variety of teaching techniques, we can help students make sense of the world in different ways, increasing the likelihood that they will develop a conceptual understanding. The teacher must be a good facilitator, monitoring and supporting group dynamics. Modeling is an instructional strategy in which the teacher demonstrates a new concept or approach to learning and pupils learn by observing. In the teaching of biology the didactic materials are fundamental tools in the teaching-learning process. Reading about scientific concepts or having a teacher explain them is not enough. Research has shown that modeling can be used across disciplines and in all grade and ability level classrooms. Using this type of instruction, teachers encourage learning.

  2. Beam-propagation method - Analysis and assessment

    Science.gov (United States)

    van Roey, J.; van der Donk, J.; Lagasse, P. E.

    1981-07-01

    A method for the calculation of the propagation of a light beam through an inhomogeneous medium is presented. A theoretical analysis of this beam-propagation method is given, and a set of conditions necessary for the accurate application of the method is derived. The method is illustrated by the study of a number of integrated-optic structures, such as thin-film waveguides and gratings.

  3. Fractal methods in image analysis and coding

    OpenAIRE

    Neary, David

    2001-01-01

    In this thesis we present an overview of image processing techniques which use fractal methods in some way. We show how these fields relate to each other, and examine various aspects of fractal methods in each area. The three principal fields of image processing and analysis th a t we examine are texture classification, image segmentation and image coding. In the area of texture classification, we examine fractal dimension estimators, comparing these methods to other methods in use, a...

  4. Kinetic analysis of anionic surfactant adsorption from aqueous solution onto activated carbon and layered double hydroxide with the zero length column method

    NARCIS (Netherlands)

    Schouten, Natasja; Ham, Louis G.J. van der; Euverink, Gert-Jan W.; Haan, André B. de

    2009-01-01

    Low cost adsorption technology offers high potential to clean-up laundry rinsing water. From an earlier selection of adsorbents, layered double hydroxide (LDH) and granular activated carbon (GAC) proved to be interesting materials for the removal of anionic surfactant, linear alkyl benzene sulfonate

  5. Optical design and active optics methods in astronomy

    Science.gov (United States)

    Lemaitre, Gerard R.

    2013-03-01

    Optical designs for astronomy involve implementation of active optics and adaptive optics from X-ray to the infrared. Developments and results of active optics methods for telescopes, spectrographs and coronagraph planet finders are presented. The high accuracy and remarkable smoothness of surfaces generated by active optics methods also allow elaborating new optical design types with high aspheric and/or non-axisymmetric surfaces. Depending on the goal and performance requested for a deformable optical surface analytical investigations are carried out with one of the various facets of elasticity theory: small deformation thin plate theory, large deformation thin plate theory, shallow spherical shell theory, weakly conical shell theory. The resulting thickness distribution and associated bending force boundaries can be refined further with finite element analysis.

  6. PERFORMANCE ANALYSIS OF METHODS FOR ESTIMATING ...

    African Journals Online (AJOL)

    2014-12-31

    Dec 31, 2014 ... analysis revealed that the MLM was the most accurate model ..... obtained using the empirical method as the same formula is used. ..... and applied meteorology, American meteorological society, October 1986, vol.25, pp.

  7. Statistical methods for categorical data analysis

    CERN Document Server

    Powers, Daniel

    2008-01-01

    This book provides a comprehensive introduction to methods and models for categorical data analysis and their applications in social science research. Companion website also available, at https://webspace.utexas.edu/dpowers/www/

  8. LANDSCAPE ANALYSIS METHOD OF RIVERINE TERRITORIES

    OpenAIRE

    Fedoseeva O. S.

    2013-01-01

    The article proposes a method for landscape area analysis, which consists of four stages. Technique is proposed as a tool for the practical application of pre-project research materials in the design solutions for landscape areas planning and organization

  9. An introduction to numerical methods and analysis

    CERN Document Server

    Epperson, James F

    2013-01-01

    Praise for the First Edition "". . . outstandingly appealing with regard to its style, contents, considerations of requirements of practice, choice of examples, and exercises.""-Zentralblatt MATH "". . . carefully structured with many detailed worked examples.""-The Mathematical Gazette The Second Edition of the highly regarded An Introduction to Numerical Methods and Analysis provides a fully revised guide to numerical approximation. The book continues to be accessible and expertly guides readers through the many available techniques of numerical methods and analysis. An Introduction to

  10. [Framework analysis method in qualitative research].

    Science.gov (United States)

    Liao, Xing; Liu, Jian-ping; Robison, Nicola; Xie, Ya-ming

    2014-05-01

    In recent years a number of qualitative research methods have gained popularity within the health care arena. Despite this popularity, different qualitative analysis methods pose many challenges to most researchers. The present paper responds to the needs expressed by recent Chinese medicine researches. The present paper is mainly focused on the concepts, nature, application of framework analysis, especially on how to use it, in such a way to assist the newcomer of Chinese medicine researchers to engage with the methodology.

  11. Two MIS Analysis Methods: An Experimental Comparison.

    Science.gov (United States)

    Wang, Shouhong

    1996-01-01

    In China, 24 undergraduate business students applied data flow diagrams (DFD) to a mini-case, and 20 used object-oriented analysis (OOA). DFD seemed easier to learn, but after training, those using the OOA method for systems analysis made fewer errors. (SK)

  12. An Analysis Method of Business Application Framework

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    We discuss the evolution of object-oriented software developmentpr o cess based on software pattern. For developing mature software fra mework and component, we advocate to elicit and incorporate software patterns fo r ensuing quality and reusability of software frameworks. On the analysis base o f requirement specification for business application domain, we present analysis method and basic role model of software framework. We also elicit analysis patt ern of framework architecture, and design basic role classes and their structure .

  13. Relating Actor Analysis Methods to Policy Problems

    NARCIS (Netherlands)

    Van der Lei, T.E.

    2009-01-01

    For a policy analyst the policy problem is the starting point for the policy analysis process. During this process the policy analyst structures the policy problem and makes a choice for an appropriate set of methods or techniques to analyze the problem (Goeller 1984). The methods of the policy anal

  14. Causal Moderation Analysis Using Propensity Score Methods

    Science.gov (United States)

    Dong, Nianbo

    2012-01-01

    This paper is based on previous studies in applying propensity score methods to study multiple treatment variables to examine the causal moderator effect. The propensity score methods will be demonstrated in a case study to examine the causal moderator effect, where the moderators are categorical and continuous variables. Moderation analysis is an…

  15. Error Analysis of Band Matrix Method

    OpenAIRE

    Taniguchi, Takeo; Soga, Akira

    1984-01-01

    Numerical error in the solution of the band matrix method based on the elimination method in single precision is investigated theoretically and experimentally, and the behaviour of the truncation error and the roundoff error is clarified. Some important suggestions for the useful application of the band solver are proposed by using the results of above error analysis.

  16. Empirical likelihood method in survival analysis

    CERN Document Server

    Zhou, Mai

    2015-01-01

    Add the Empirical Likelihood to Your Nonparametric ToolboxEmpirical Likelihood Method in Survival Analysis explains how to use the empirical likelihood method for right censored survival data. The author uses R for calculating empirical likelihood and includes many worked out examples with the associated R code. The datasets and code are available for download on his website and CRAN.The book focuses on all the standard survival analysis topics treated with empirical likelihood, including hazard functions, cumulative distribution functions, analysis of the Cox model, and computation of empiric

  17. A new analysis method using Bragg curve spectroscopy for a Multi-purpose Active-target Particle Telescope for radiation monitoring

    Science.gov (United States)

    Losekamm, M. J.; Milde, M.; Pöschl, T.; Greenwald, D.; Paul, S.

    2017-02-01

    Traditional radiation detectors can either measure the total radiation dose omnidirectionally (dosimeters), or determine the incoming particles characteristics within a narrow field of view (spectrometers). Instantaneous measurements of anisotropic fluxes thus require several detectors, resulting in bulky setups. The Multi-purpose Active-target Particle Telescope (MAPT), employing a new detection principle, is designed to measure particle fluxes omnidirectionally and be simultaneously a dosimeter and spectrometer. It consists of an active core of scintillating fibers whose light output is measured by silicon photomultipliers, and fits into a cube with an edge length of 10 cm. It identifies particles using extended Bragg curve spectroscopy, with sensitivity to charged particles with kinetic energies above 25 MeV. MAPT's unique layout results in a geometrical acceptance of approximately 800 cm2 sr and an angular resolution of less than 6°, which can be improved by track-fitting procedures. In a beam test of a simplified prototype, the energy resolution was found to be less than 1 MeV for protons with energies between 30 and 70 MeV. Possible applications of MAPT include the monitoring of radiation environments in spacecraft and beam monitoring in medical facilities.

  18. Scope-Based Method Cache Analysis

    DEFF Research Database (Denmark)

    Huber, Benedikt; Hepp, Stefan; Schoeberl, Martin

    2014-01-01

    , as it requests memory transfers at well-defined instructions only. In this article, we present a new cache analysis framework that generalizes and improves work on cache persistence analysis. The analysis demonstrates that a global view on the cache behavior permits the precise analyses of caches which are hard......The quest for time-predictable systems has led to the exploration of new hardware architectures that simplify analysis and reasoning in the temporal domain, while still providing competitive performance. For the instruction memory, the method cache is a conceptually attractive solution...

  19. 沟通分析理论的活用——大学生的职场沟通能力分析法%The Active Use of Transactional Analysis Theory: Analysis Method of the Students' Workplace Communication Skills

    Institute of Scientific and Technical Information of China (English)

    芦文利

    2012-01-01

    Transactional Analysis theory (TA) is founded by Eric Berne in the 1960s, it is a kind of psychological theory to study people's thinking, feelings and behavior. This paper focuses on the students who will go to work to provide an analysis method for the professional communication skills of students.%沟通分析理论(简称TA)是由Eric Berne于60年代创立.是一种研究人们思想、感情及行为的心理学理论.本文着眼于将要就职的大学生,对大学生的职业沟通能力提供分析方法.

  20. Assessment of the active method to determine soil moisture

    Directory of Open Access Journals (Sweden)

    José Luis Serna Farfan

    2017-07-01

    Full Text Available In recent years, fiber-optic distributed temperature sensing (FO-DTS methods have been successfully used to investigate a wide range of hydrological applications. In particular, two methods have been developed to monitor the soil water content (θ with the FO-DTS technology: the passive and the active methods. This work presents an assessment of the active method to determine the θ of a sandy soil. In this method, fiber-optic cables with metallic armoring are used and a voltage difference is applied between the two ends of the cable to warm it during a specified time period. Then, an empirical relationship is used to relate θ with a parameter called cumulative temperature (Tcum . To apply the active method, we propose a potential relationship defined by stretches, which depends on the hydrodynamic properties of the soil studied. Different experiments were carried out to assess the active method. These experiments had different heat pulse durations (2, 5, 10 and 20 min with electrical powers of 2.1, 2.6, 2.3 and 2.4 W/m, respectively, and allowed determining the optimum heat pulse duration (tf , the optimum temporal integration interval (Δt, the optimum final time of integration (t0 used in the calculation of the cumulative temperature, and the optimum current (I that should circulate through the fiber-optic cable to generate the heat pulse. Results show that the optimum operating parameters are: tf = 1200 s Δt = 150 s, t0 = tf, and I ≈ 17 A (2.43 W/m. Our analysis allowed obtaining volumetric water contents ranging from 0.14 to 0.46 m3/m3, with errors that are smaller than 0.08 m3/m3.

  1. Wavelet methods in mathematical analysis and engineering

    CERN Document Server

    Damlamian, Alain

    2010-01-01

    This book gives a comprehensive overview of both the fundamentals of wavelet analysis and related tools, and of the most active recent developments towards applications. It offers a stateoftheart in several active areas of research where wavelet ideas, or more generally multiresolution ideas have proved particularly effective. The main applications covered are in the numerical analysis of PDEs, and signal and image processing. Recently introduced techniques such as Empirical Mode Decomposition (EMD) and new trends in the recovery of missing data, such as compressed sensing, are also presented.

  2. Spatial analysis statistics, visualization, and computational methods

    CERN Document Server

    Oyana, Tonny J

    2015-01-01

    An introductory text for the next generation of geospatial analysts and data scientists, Spatial Analysis: Statistics, Visualization, and Computational Methods focuses on the fundamentals of spatial analysis using traditional, contemporary, and computational methods. Outlining both non-spatial and spatial statistical concepts, the authors present practical applications of geospatial data tools, techniques, and strategies in geographic studies. They offer a problem-based learning (PBL) approach to spatial analysis-containing hands-on problem-sets that can be worked out in MS Excel or ArcGIS-as well as detailed illustrations and numerous case studies. The book enables readers to: Identify types and characterize non-spatial and spatial data Demonstrate their competence to explore, visualize, summarize, analyze, optimize, and clearly present statistical data and results Construct testable hypotheses that require inferential statistical analysis Process spatial data, extract explanatory variables, conduct statisti...

  3. Advanced Analysis Methods in Particle Physics

    Energy Technology Data Exchange (ETDEWEB)

    Bhat, Pushpalatha C. [Fermilab

    1900-01-01

    Each generation of high energy physics experiments is grander in scale than the previous – more powerful, more complex and more demanding in terms of data handling and analysis. The spectacular performance of the Tevatron and the beginning of operations of the Large Hadron Collider, have placed us at the threshold of a new era in particle physics. The discovery of the Higgs boson or another agent of electroweak symmetry breaking and evidence of new physics may be just around the corner. The greatest challenge in these pursuits is to extract the extremely rare signals, if any, from huge backgrounds arising from known physics processes. The use of advanced analysis techniques is crucial in achieving this goal. In this review, I discuss the concepts of optimal analysis, some important advanced analysis methods and a few examples. The judicious use of these advanced methods should enable new discoveries and produce results with better precision, robustness and clarity.

  4. Advanced analysis methods in particle physics

    Energy Technology Data Exchange (ETDEWEB)

    Bhat, Pushpalatha C.; /Fermilab

    2010-10-01

    Each generation of high energy physics experiments is grander in scale than the previous - more powerful, more complex and more demanding in terms of data handling and analysis. The spectacular performance of the Tevatron and the beginning of operations of the Large Hadron Collider, have placed us at the threshold of a new era in particle physics. The discovery of the Higgs boson or another agent of electroweak symmetry breaking and evidence of new physics may be just around the corner. The greatest challenge in these pursuits is to extract the extremely rare signals, if any, from huge backgrounds arising from known physics processes. The use of advanced analysis techniques is crucial in achieving this goal. In this review, I discuss the concepts of optimal analysis, some important advanced analysis methods and a few examples. The judicious use of these advanced methods should enable new discoveries and produce results with better precision, robustness and clarity.

  5. Analysis of mixed data methods & applications

    CERN Document Server

    de Leon, Alexander R

    2013-01-01

    A comprehensive source on mixed data analysis, Analysis of Mixed Data: Methods & Applications summarizes the fundamental developments in the field. Case studies are used extensively throughout the book to illustrate interesting applications from economics, medicine and health, marketing, and genetics. Carefully edited for smooth readability and seamless transitions between chaptersAll chapters follow a common structure, with an introduction and a concluding summary, and include illustrative examples from real-life case studies in developmental toxicolog

  6. Chromatographic methods for analysis of triazine herbicides.

    Science.gov (United States)

    Abbas, Hana Hassan; Elbashir, Abdalla A; Aboul-Enein, Hassan Y

    2015-01-01

    Gas chromatography (GC) and high-performance liquid chromatography (HPLC) coupled to different detectors, and in combination with different sample extraction methods, are most widely used for analysis of triazine herbicides in different environmental samples. Nowadays, many variations and modifications of extraction and sample preparation methods such as solid-phase microextraction (SPME), hollow fiber-liquid phase microextraction (HF-LPME), stir bar sportive extraction (SBSE), headspace-solid phase microextraction (HS-SPME), dispersive liquid-liquid microextraction (DLLME), dispersive liquid-liquid microextraction based on solidification of floating organic droplet (DLLME-SFO), ultrasound-assisted emulsification microextraction (USAEME), and others have been introduced and developed to obtain sensitive and accurate methods for the analysis of these hazardous compounds. In this review, several analytical properties such as linearity, sensitivity, repeatability, and accuracy for each developed method are discussed, and excellent results were obtained for the most of developed methods combined with GC and HPLC techniques for the analysis of triazine herbicides. This review gives an overview of recent publications of the application of GC and HPLC for analysis of triazine herbicides residues in various samples.

  7. Probabilistic Analysis Methods for Hybrid Ventilation

    DEFF Research Database (Denmark)

    Brohus, Henrik; Frier, Christian; Heiselberg, Per

    This paper discusses a general approach for the application of probabilistic analysis methods in the design of ventilation systems. The aims and scope of probabilistic versus deterministic methods are addressed with special emphasis on hybrid ventilation systems. A preliminary application of stoc...... of stochastic differential equations is presented comprising a general heat balance for an arbitrary number of loads and zones in a building to determine the thermal behaviour under random conditions....

  8. An introduction to numerical methods and analysis

    CERN Document Server

    Epperson, J F

    2007-01-01

    Praise for the First Edition "". . . outstandingly appealing with regard to its style, contents, considerations of requirements of practice, choice of examples, and exercises.""-Zentrablatt Math "". . . carefully structured with many detailed worked examples . . .""-The Mathematical Gazette "". . . an up-to-date and user-friendly account . . .""-Mathematika An Introduction to Numerical Methods and Analysis addresses the mathematics underlying approximation and scientific computing and successfully explains where approximation methods come from, why they sometimes work (or d

  9. Methods for genetic linkage analysis using trisomies

    Energy Technology Data Exchange (ETDEWEB)

    Feingold, E. [Emory Univ. School of Public Health, Atlanta, GA (United States); Lamb, N.E.; Sherman, S.L. [Emory Univ., Atlanta, GA (United States)

    1995-02-01

    Certain genetic disorders are rare in the general population, but more common in individuals with specific trisomies. Examples of this include leukemia and duodenal atresia in trisomy 21. This paper presents a linkage analysis method for using trisomic individuals to map genes for such traits. It is based on a very general gene-specific dosage model that posits that the trait is caused by specific effects of different alleles at one or a few loci and that duplicate copies of {open_quotes}susceptibility{close_quotes} alleles inherited from the nondisjoining parent give increased likelihood of having the trait. Our mapping method is similar to identity-by-descent-based mapping methods using affected relative pairs and also to methods for mapping recessive traits using inbred individuals by looking for markers with greater than expected homozygosity by descent. In the trisomy case, one would take trisomic individuals and look for markers with greater than expected homozygosity in the chromosomes inherited from the nondisjoining parent. We present statistical methods for performing such a linkage analysis, including a test for linkage to a marker, a method for estimating the distance from the marker to the trait gene, a confidence interval for that distance, and methods for computing power and sample sizes. We also resolve some practical issues involved in implementing the methods, including how to use partially informative markers and how to test candidate genes. 20 refs., 5 figs., 1 tab.

  10. [Methods for grain size analysis of nanomedicines].

    Science.gov (United States)

    Geng, Zhi-Wang; He, Lan; Zhang, Qi-Ming; Yang, Yong-Jian

    2012-07-01

    As nanomedicines are developing fast in both academic and market areas, building up suitable methods for nanomedicine analysis with proper techniques is an important subject, requiring further research. The techniques, which could be employed for grain size analysis of nanomedicines, were reviewed. Several key techniques were discussed with their principles, scope of applications, advantages and defects. Their applications to nanomedine analysis were discussed according to the properties of different nanomedicines, with the purpose of providing some suggestions for the control and administration of nanomedicines.

  11. Analysis of neutron flux distribution using the Monte Carlo method for the feasibility study of the Prompt Gamma Activation Analysis technique at the IPR-R1 TRIGA reactor

    Energy Technology Data Exchange (ETDEWEB)

    Guerra, Bruno T.; Pereira, Claubia, E-mail: brunoteixeiraguerra@yahoo.com.br, E-mail: claubia@nuclear.ufmg.br [Universidade Federal de Minas Gerais (DEN/UFMG), Belo Horizonte, MG (Brazil). Departmento de Energia Nuclear; Soares, Alexandre L.; Menezes, Maria Angela B.C., E-mail: menezes@cdtn.br, E-mail: asleal@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2015-07-01

    The IPR-R1 is a reactor type TRIGA, Mark-I model, manufactured by the General Atomic Company and installed at Nuclear Technology Development Centre (CDTN), Brazilian Commission for Nuclear Energy (CNEN), in Belo Horizonte, Brazil. It is a light water moderated and cooled, graphite-reflected, open-pool type research reactor and operates at 100 kW. It presents low power, low pressure, for application in research, training and radioisotopes production. The fuel is an alloy of zirconium hydride and uranium enriched at 20% in {sup 235}U. The implementation of the PGNAA (Prompt Gamma Neutron Activation Analysis) using this research reactor will significantly increase in number of chemical elements analysed and the kind of matrices. A project is underway in order to implement this technique at CDTN. The objective of this study was to contribute in feasibility analysis of implementing this technique. For this purpose, MCNP is being used. Some variance reduction tools in the methodology, that has been already developed, was introduced for calculating of the neutron flux in the neutron extractor inclined. The objective was to reduce the code error and thereby increasing the reliability of the results. With the implementation of the variance reduction tools, the results of the thermal and epithermal neutron fluxes presented a significant improvement in both calculations. (author)

  12. Method for enhancing amidohydrolase activity of fatty acid amide hydrolase

    Energy Technology Data Exchange (ETDEWEB)

    John, George; Nagarajan, Subbiah; Chapman, Kent; Faure, Lionel; Koulen, Peter

    2016-10-25

    A method for enhancing amidohydrolase activity of Fatty Acid Amide Hydrolase (FAAH) is disclosed. The method comprising administering a phenoxyacylethanolamide that causes the enhanced activity. The enhanced activity can have numerous effects on biological organisms including, for example, enhancing the growth of certain seedlings. The subject matter disclosed herein relates to enhancers of amidohydrolase activity.

  13. Numerical methods in software and analysis

    CERN Document Server

    Rice, John R

    1992-01-01

    Numerical Methods, Software, and Analysis, Second Edition introduces science and engineering students to the methods, tools, and ideas of numerical computation. Introductory courses in numerical methods face a fundamental problem-there is too little time to learn too much. This text solves that problem by using high-quality mathematical software. In fact, the objective of the text is to present scientific problem solving using standard mathematical software. This book discusses numerous programs and software packages focusing on the IMSL library (including the PROTRAN system) and ACM Algorithm

  14. Model correction factor method for system analysis

    DEFF Research Database (Denmark)

    Ditlevsen, Ove Dalager; Johannesen, Johannes M.

    2000-01-01

    The Model Correction Factor Method is an intelligent response surface method based on simplifiedmodeling. MCFM is aimed for reliability analysis in case of a limit state defined by an elaborate model. Herein it isdemonstrated that the method is applicable for elaborate limit state surfaces on which...... severallocally most central points exist without there being a simple geometric definition of the corresponding failuremodes such as is the case for collapse mechanisms in rigid plastic hinge models for frame structures. Taking as simplifiedidealized model a model of similarity with the elaborate model...... surface than existing in the idealized model....

  15. Organic reagents in spectrophotometric methods of analysis

    Energy Technology Data Exchange (ETDEWEB)

    Savvin, Sergey B; Mikhailova, Alla V [V.I. Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Moscow (Russian Federation); Shtykov, S N [Department of Chemistry, N.G. Chernyshevskii Saratov State University (Russian Federation)

    2006-04-30

    The role of organic, in particular, complex-forming, reagents in the formation and development of spectrophotometric analysis is discussed. The prospects for the use of organic reagents in modern analytical methods are considered; the attention is focused on modified and immobilised reagents, receptor molecules and on the use of nonaqueous and organised media.

  16. Systems and methods for sample analysis

    Energy Technology Data Exchange (ETDEWEB)

    Cooks, Robert Graham; Li, Guangtao; Li, Xin; Ouyang, Zheng

    2015-10-20

    The invention generally relates to systems and methods for sample analysis. In certain embodiments, the invention provides a system for analyzing a sample that includes a probe including a material connected to a high voltage source, a device for generating a heated gas, and a mass analyzer.

  17. Modern methods of wine quality analysis

    Directory of Open Access Journals (Sweden)

    Галина Зуфарівна Гайда

    2015-06-01

    Full Text Available  In this paper physical-chemical and enzymatic methods of quantitative analysis of the basic wine components were reviewed. The results of own experiments were presented for the development of enzyme- and cell-based amperometric sensors on ethanol, lactate, glucose, arginine

  18. Single-cell analysis - Methods and protocols

    OpenAIRE

    Carlo Alberto Redi

    2013-01-01

    This is certainly a timely volume in the Methods in molecular biology series: we already entered the synthetic biology era and thus we need to be aware of the new methodological advances able to fulfill the new and necessary needs for biologists, biotechnologists and nano-biotechnologists. Notably, among these, the possibility to perform single cell analysis allow researchers to capture single cell responses....

  19. ASAAM: Aspectual Sofware Architecture Analysis Method

    NARCIS (Netherlands)

    Tekinerdogan, B.

    Software architecture analysis methods aim to predict the quality of a system before it has been developed. In general, the quality of the architecture is validated by analyzing the impact of predefined scenarios on architectural components. Hereby, it is implicitly assumed that an appropriate

  20. Drawing up of a procedure for vanadium determination in mussels using the neutron activation analysis method; Estabelecimento de procedimento para determinacao de vanadio em mexilhoes pelo metodo de analise por ativacao com neutrons

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Daniele, E-mail: danyseo@uol.com.b [Universidade Presbiteriana Mackenzie, Sao Paulo, SP (Brazil). Centro de Ciencias Biologicas e da Saude; Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Vasconcellos, Marina B.A.; Saiki, Mitiko; Catharino, Marilia G.M.; Moreira, Edson G., E-mail: mbvascon@ipen.b, E-mail: mitiko@ipen.b, E-mail: mgcatharino@uol.com.b, E-mail: emoreira@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Sousa, Eduinetty C.P.M. de; Pereira, Camilo D.S., E-mail: edvinett@usp.b, E-mail: camilo.pereira@usp.b [Universidade de Sao Paulo (IO/USP), SP (Brazil). Inst. Oceanografico. Lab. de Ecotoxicologia Marinha

    2009-07-01

    This work establishes an adequate procedure for obtaining reliable results for determination of vanadium in mussels, leg by leg by the neutron activation analysis (NAA), viewing the posterior application on the bio monitoring the coastal pollution, particularly near the petroleum terminals.For the evaluation of result quality concerning to the quality of those results, the work analysed the reference material certification NIST SRM 1566b Oyster Tissue. The precision of the results were also analysed using repetitions of mussel samples collected at the coastal of northern Sao Paulo state, Brazil. The NAA procedure consisted of 200 mg of sample and a synthetic standard of vanadium during a period of 8 s and under a thermal neutron flux of 6.6 x 10{sup 12} n cm{sup -2} s{sup -1} at the pneumatic station 4 of the IEA-R1 nuclear reactor of IPEN-CNEN/SP. After a 3 min decay, the measurements of the gamma activities of the sample and the standard were done using a Ge hyper pure semi-conductor detector, connected to gamma ray multichannel analyser. The vanadium were determined by the measurement of the gamma activity of the {sup 52}V through the 1434.08 keV peak, and half-life time of 3.75 min. The concentration of V were calculated by the comparative method. The obtained results indicated the viability of the NAA procedure established for the determination of vanadium in mussels

  1. Digital Forensics Analysis of Spectral Estimation Methods

    CERN Document Server

    Mataracioglu, Tolga

    2011-01-01

    Steganography is the art and science of writing hidden messages in such a way that no one apart from the intended recipient knows of the existence of the message. In today's world, it is widely used in order to secure the information. In this paper, the traditional spectral estimation methods are introduced. The performance analysis of each method is examined by comparing all of the spectral estimation methods. Finally, from utilizing those performance analyses, a brief pros and cons of the spectral estimation methods are given. Also we give a steganography demo by hiding information into a sound signal and manage to pull out the information (i.e, the true frequency of the information signal) from the sound by means of the spectral estimation methods.

  2. Spectroscopic Chemical Analysis Methods and Apparatus

    Science.gov (United States)

    Hug, William F. (Inventor); Reid, Ray D. (Inventor); Bhartia, Rohit (Inventor); Lane, Arthur L. (Inventor)

    2017-01-01

    Spectroscopic chemical analysis methods and apparatus are disclosed which employ deep ultraviolet (e.g. in the 200 nm to 300 nm spectral range) electron beam pumped wide bandgap semiconductor lasers, incoherent wide bandgap semiconductor light emitting devices, and hollow cathode metal ion lasers to perform non-contact, non-invasive detection of unknown chemical analytes. These deep ultraviolet sources enable dramatic size, weight and power consumption reductions of chemical analysis instruments. In some embodiments, Raman spectroscopic detection methods and apparatus use ultra-narrow-band angle tuning filters, acousto-optic tuning filters, and temperature tuned filters to enable ultra-miniature analyzers for chemical identification. In some embodiments Raman analysis is conducted along with photoluminescence spectroscopy (i.e. fluorescence and/or phosphorescence spectroscopy) to provide high levels of sensitivity and specificity in the same instrument.

  3. Practical Fourier analysis for multigrid methods

    CERN Document Server

    Wienands, Roman

    2004-01-01

    Before applying multigrid methods to a project, mathematicians, scientists, and engineers need to answer questions related to the quality of convergence, whether a development will pay out, whether multigrid will work for a particular application, and what the numerical properties are. Practical Fourier Analysis for Multigrid Methods uses a detailed and systematic description of local Fourier k-grid (k=1,2,3) analysis for general systems of partial differential equations to provide a framework that answers these questions.This volume contains software that confirms written statements about convergence and efficiency of algorithms and is easily adapted to new applications. Providing theoretical background and the linkage between theory and practice, the text and software quickly combine learning by reading and learning by doing. The book enables understanding of basic principles of multigrid and local Fourier analysis, and also describes the theory important to those who need to delve deeper into the detai...

  4. Multiple predictor smoothing methods for sensitivity analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Helton, Jon Craig; Storlie, Curtis B.

    2006-08-01

    The use of multiple predictor smoothing methods in sampling-based sensitivity analyses of complex models is investigated. Specifically, sensitivity analysis procedures based on smoothing methods employing the stepwise application of the following nonparametric regression techniques are described: (1) locally weighted regression (LOESS), (2) additive models, (3) projection pursuit regression, and (4) recursive partitioning regression. The indicated procedures are illustrated with both simple test problems and results from a performance assessment for a radioactive waste disposal facility (i.e., the Waste Isolation Pilot Plant). As shown by the example illustrations, the use of smoothing procedures based on nonparametric regression techniques can yield more informative sensitivity analysis results than can be obtained with more traditional sensitivity analysis procedures based on linear regression, rank regression or quadratic regression when nonlinear relationships between model inputs and model predictions are present.

  5. Simple gas chromatographic method for furfural analysis.

    Science.gov (United States)

    Gaspar, Elvira M S M; Lopes, João F

    2009-04-03

    A new, simple, gas chromatographic method was developed for the direct analysis of 5-hydroxymethylfurfural (5-HMF), 2-furfural (2-F) and 5-methylfurfural (5-MF) in liquid and water soluble foods, using direct immersion SPME coupled to GC-FID and/or GC-TOF-MS. The fiber (DVB/CAR/PDMS) conditions were optimized: pH effect, temperature, adsorption and desorption times. The method is simple and accurate (RSDTOF-MS: 0.3, 1.2 and 0.9 ngmL(-1) for 2-F, 5-MF and 5-HMF, respectively). It was applied to different commercial food matrices: honey, white, demerara, brown and yellow table sugars, and white and red balsamic vinegars. This one-step, sensitive and direct method for the analysis of furfurals will contribute to characterise and quantify their presence in the human diet.

  6. Heteroscedastic regression analysis method for mixed data

    Institute of Scientific and Technical Information of China (English)

    FU Hui-min; YUE Xiao-rui

    2011-01-01

    The heteroscedastic regression model was established and the heteroscedastic regression analysis method was presented for mixed data composed of complete data, type- I censored data and type- Ⅱ censored data from the location-scale distribution. The best unbiased estimations of regression coefficients, as well as the confidence limits of the location parameter and scale parameter were given. Furthermore, the point estimations and confidence limits of percentiles were obtained. Thus, the traditional multiple regression analysis method which is only suitable to the complete data from normal distribution can be extended to the cases of heteroscedastic mixed data and the location-scale distribution. So the presented method has a broad range of promising applications.

  7. Electromyographic analysis: shoulder muscle activity revisited.

    Science.gov (United States)

    Heuberer, Philipp; Kranzl, Andreas; Laky, Brenda; Anderl, Werner; Wurnig, Christian

    2015-04-01

    Restoring optimal strength and biomechanics of a pathologic shoulder knowledge of activity patterns of healthy glenohumeral muscles is mandatory. Yet, data on normal shoulder muscle activity are not always conclusive. The study was undertaken (a) to evaluate muscle activity patterns in the healthy shoulder using surface and fine-wire electromyography (EMG), and (b) to assess method's suitability in the clinical setting especially regarding painfulness and practicability. Surface and fine-wire EMG was performed on 11 healthy subjects (2f/9 m, Ø age 28 years) to assess 14 muscles including rotator cuff muscles during 8 planar standardised shoulder movements (abduction, forward flexion, internal and external rotation in neutral, 45° and 90° abduction). Pain was assessed using the visual analogue scale before testing, after inserting the fine-wire electrodes, after maximal voluntary contraction, before and after exercises, and after electrode removal. The most important finding regarding EMG activity patterns in the healthy shoulder was that the subscapularis activity was found to play a major role in abduction and forward flexion. Furthermore, this study was able to show that EMG measurements, especially fine-wire EMG, is prone to high failure rates (up to 32%); however, pain was not a limiting factor. The present study (1) revealed a new insight, especially finding the subscapularis activity playing a major role in abduction and forward flexion of the healthy shoulder; and (2) motion analysis system and the use of fine-wire electrodes were prone to failure; however, pain was not a limiting factor. Basic Science, Electrodiagnostic Study.

  8. Activity Landscape Plotter: A Web-based Application for the Analysis of Structure-Activity Relationships.

    Science.gov (United States)

    González-Medina, Mariana; Méndez-Lucio, Oscar; Medina-Franco, Jose Luis

    2017-02-24

    Activity landscape modeling is a powerful method for the quantitative analysis of structure-activity relationships. This cheminformatics area is in continuous growth and several quantitative and visual approaches are constantly being developed. However, these approaches often fall into disuse due to their limited access. Herein, we present Activity Landscape Plotter as the first freely available web-based tool to automatically analyze structure-activity relationships of compound data sets. Based on the concept of activity landscape modeling, the online service performs pair-wise structure and activity relationships from an input data set supplied by the user. For visual analysis, Activity Landscape Plotter generates Structure-Activity Similarity and Dual Activity Difference maps. The user can interactively navigate through the maps and export all the pairwise structure-activity information as comma delimited files. Activity Landscape Plotter is freely accessible at https://unam-shiny-difacquim.shinyapps.io/ActLSmaps/.

  9. Methods for genetic linkage analysis using trisomies

    Energy Technology Data Exchange (ETDEWEB)

    Feingold, E.; Lamb, N.E.; Sherman, S.L. [Emory Univ., Atlanta, GA (United States)

    1994-09-01

    Certain genetic disorders (e.g. congenital cataracts, duodenal atresia) are rare in the general population, but more common in people with Down`s syndrome. We present a method for using individuals with trisomy 21 to map genes for such traits. Our methods are analogous to methods for mapping autosomal dominant traits using affected relative pairs by looking for markers with greater than expected identity-by-descent. In the trisomy case, one would take trisomic individuals and look for markers with greater than expected reduction to homozygosity in the chromosomes inherited form the non-disjoining parent. We present statistical methods for performing such a linkage analysis, including a test for linkage to a marker, a method for estimating the distance from the marker to the gene, a confidence interval for that distance, and methods for computing power and sample sizes. The methods are described in the context of gene-dosage model for the etiology of the disorder, but can be extended to other models. We also resolve some practical issues involved in implementing the methods, including how to use partially informative markers, how to test candidate genes, and how to handle the effect of reduced recombination associated with maternal meiosis I non-disjunction.

  10. Geometric Variational Methods for Controlled Active Vision

    Science.gov (United States)

    2006-08-01

    Kantorovich mass transfer problem,” Numerische Mathematik 84 (2000), pp. 375-393. [14] A. Blake and M. Isard , Active Contours, Springer-Verlag, New York...flow,” Artificial Intelligence, 23:185– 203, 1981. [59] M. Isard and A. Blake, ”CONDENSATION – conditional density propagation for visual tracking

  11. A DECOMPOSITION METHOD OF STRUCTURAL DECOMPOSITION ANALYSIS

    Institute of Scientific and Technical Information of China (English)

    LI Jinghua

    2005-01-01

    Over the past two decades,structural decomposition analysis(SDA)has developed into a major analytical tool in the field of input-output(IO)techniques,but the method was found to suffer from one or more of the following problems.The decomposition forms,which are used to measure the contribution of a specific determinant,are not unique due to the existence of a multitude of equivalent forms,irrational due to the weights of different determinants not matching,inexact due to the existence of large interaction terms.In this paper,a decomposition method is derived to overcome these deficiencies,and we prove that the result of this approach is equal to the Shapley value in cooperative games,and so some properties of the method are obtained.Beyond that,the two approaches that have been used predominantly in the literature have been proved to be the approximate solutions of the method.

  12. Methods of Analysis of Electronic Money in Banks

    Directory of Open Access Journals (Sweden)

    Melnychenko Oleksandr V.

    2014-03-01

    Full Text Available The article identifies methods of analysis of electronic money, formalises its instruments and offers an integral indicator, which should be calculated by issuing banks and those banks, which carry out operations with electronic money, issued by other banks. Calculation of the integral indicator would allow complex assessment of activity of the studied bank with electronic money and would allow comparison of parameters of different banks by the aggregate of indicators for the study of the electronic money market, its level of development, etc. The article presents methods which envisage economic analysis of electronic money in banks by the following directions: solvency and liquidity, efficiency of electronic money issue, business activity of the bank and social responsibility. Moreover, the proposed indicators by each of the directions are offered to be taken into account when building integral indicators, with the help of which banks are studied: business activity, profitability, solvency, liquidity and so on.

  13. Method of thermal derivative gradient analysis (TDGA

    Directory of Open Access Journals (Sweden)

    M. Cholewa

    2009-07-01

    Full Text Available In this work a concept of thermal analysis was shown, using for crystallization kinetics description the temperature derivatives after time and direction. Method of thermal derivative gradient analysis (TDGA is assigned for alloys and metals investigation as well as cast composites in range of solidification. The construction and operation characteristics were presented for the test stand including processing modules and probes together with thermocouples location. Authors presented examples of results interpretation for AlSi11 alloy castings with diversified wall thickness and at different pouring temperature.

  14. Reduction Method for Active Distribution Networks

    DEFF Research Database (Denmark)

    Raboni, Pietro; Chen, Zhe

    2013-01-01

    On-line security assessment is traditionally performed by Transmission System Operators at the transmission level, ignoring the effective response of distributed generators and small loads. On the other hand the required computation time and amount of real time data for including Distribution...... Networks also would be too large. In this paper an adaptive aggregation method for subsystems with power electronic interfaced generators and voltage dependant loads is proposed. With this tool may be relatively easier including distribution networks into security assessment. The method is validated...

  15. Model-based methods for linkage analysis.

    Science.gov (United States)

    Rice, John P; Saccone, Nancy L; Corbett, Jonathan

    2008-01-01

    The logarithm of an odds ratio (LOD) score method originated in a seminal article by Newton Morton in 1955. The method is broadly concerned with issues of power and the posterior probability of linkage, ensuring that a reported linkage has a high probability of being a true linkage. In addition, the method is sequential so that pedigrees or LOD curves may be combined from published reports to pool data for analysis. This approach has been remarkably successful for 50 years in identifying disease genes for Mendelian disorders. After discussing these issues, we consider the situation for complex disorders where the maximum LOD score statistic shares some of the advantages of the traditional LOD score approach, but is limited by unknown power and the lack of sharing of the primary data needed to optimally combine analytic results. We may still learn from the LOD score method as we explore new methods in molecular biology and genetic analysis to utilize the complete human DNA sequence and the cataloging of all human genes.

  16. Spatial Analysis Methods of Road Traffic Collisions

    DEFF Research Database (Denmark)

    Loo, Becky P. Y.; Anderson, Tessa Kate

    Spatial Analysis Methods of Road Traffic Collisions centers on the geographical nature of road crashes, and uses spatial methods to provide a greater understanding of the patterns and processes that cause them. Written by internationally known experts in the field of transport geography, the book...... outlines the key issues in identifying hazardous road locations (HRLs), considers current approaches used for reducing and preventing road traffic collisions, and outlines a strategy for improved road safety. The book covers spatial accuracy, validation, and other statistical issues, as well as link...

  17. ANALYSIS METHOD OF AUTOMATIC PLANETARY TRANSMISSION KINEMATICS

    Directory of Open Access Journals (Sweden)

    Józef DREWNIAK

    2014-06-01

    Full Text Available In the present paper, planetary automatic transmission is modeled by means of contour graphs. The goals of modeling could be versatile: ratio calculating via algorithmic equation generation, analysis of velocity and accelerations. The exemplary gears running are analyzed, several drives/gears are consecutively taken into account discussing functional schemes, assigned contour graphs and generated system of equations and their solutions. The advantages of the method are: algorithmic approach, general approach where particular drives are cases of the generally created model. Moreover, the method allows for further analyzes and synthesis tasks e.g. checking isomorphism of design solutions.

  18. Quantitative gold nanoparticle analysis methods: A review.

    Science.gov (United States)

    Yu, Lei; Andriola, Angelo

    2010-08-15

    Research and development in the area of gold nanoparticles' (AuNPs) preparation, characterization, and applications are burgeoning in recent years. Many of the techniques and protocols are very mature, but two major concerns are with the mass domestic production and the consumption of AuNP based products. First, how many AuNPs exist in a dispersion? Second, where are the AuNPs after digestion by the environment and how many are there? To answer these two questions, reliable and reproducible methods are needed to analyze the existence and the population of AuNP in samples. This review summarized the most recent chemical and particle quantitative analysis methods that have been used to characterize the concentration (in number of moles of gold per liter) or population (in number of particles per mL) of AuNPs. The methods summarized in this review include, mass spectroscopy, electroanalytical methods, spectroscopic methods, and particle counting methods. These methods may count the number of AuNP directly or analyze the total concentration of element gold in an AuNP dispersion.

  19. Cloud Based Development Issues: A Methodical Analysis

    Directory of Open Access Journals (Sweden)

    Sukhpal Singh

    2012-11-01

    Full Text Available Cloud based development is a challenging task for various software engineering projects, especifically for those which demand extraordinary quality, reusability and security along with general architecture. In this paper we present a report on a methodical analysis of cloud based development problems published in major computer science and software engineering journals and conferences organized by various researchers. Research papers were collected from different scholarly databases using search engines within a particular period of time. A total of 89 research papers were analyzed in this methodical study and we categorized into four classes according to the problems addressed by them. The majority of the research papers focused on quality (24 papers associated with cloud based development and 16 papers focused on analysis and design. By considering the areas focused by existing authors and their gaps, untouched areas of cloud based development can be discovered for future research works.

  20. Numerical methods and analysis of multiscale problems

    CERN Document Server

    Madureira, Alexandre L

    2017-01-01

    This book is about numerical modeling of multiscale problems, and introduces several asymptotic analysis and numerical techniques which are necessary for a proper approximation of equations that depend on different physical scales. Aimed at advanced undergraduate and graduate students in mathematics, engineering and physics – or researchers seeking a no-nonsense approach –, it discusses examples in their simplest possible settings, removing mathematical hurdles that might hinder a clear understanding of the methods. The problems considered are given by singular perturbed reaction advection diffusion equations in one and two-dimensional domains, partial differential equations in domains with rough boundaries, and equations with oscillatory coefficients. This work shows how asymptotic analysis can be used to develop and analyze models and numerical methods that are robust and work well for a wide range of parameters.

  1. Qualitative data analysis a methods sourcebook

    CERN Document Server

    Miles, Matthew B; Saldana, Johnny

    2014-01-01

    The Third Edition of Miles & Huberman's classic research methods text is updated and streamlined by Johnny SaldaNa, author of The Coding Manual for Qualitative Researchers. Several of the data display strategies from previous editions are now presented in re-envisioned and reorganized formats to enhance reader accessibility and comprehension. The Third Edition's presentation of the fundamentals of research design and data management is followed by five distinct methods of analysis: exploring, describing, ordering, explaining, and predicting. Miles and Huberman's original research studies are profiled and accompanied with new examples from SaldaNa's recent qualitative work. The book's most celebrated chapter, "Drawing and Verifying Conclusions," is retained and revised, and the chapter on report writing has been greatly expanded, and is now called "Writing About Qualitative Research." Comprehensive and authoritative, Qualitative Data Analysis has been elegantly revised for a new generation of qualitative r...

  2. Digital dream analysis: a revised method.

    Science.gov (United States)

    Bulkeley, Kelly

    2014-10-01

    This article demonstrates the use of a digital word search method designed to provide greater accuracy, objectivity, and speed in the study of dreams. A revised template of 40 word search categories, built into the website of the Sleep and Dream Database (SDDb), is applied to four "classic" sets of dreams: The male and female "Norm" dreams of Hall and Van de Castle (1966), the "Engine Man" dreams discussed by Hobson (1988), and the "Barb Sanders Baseline 250" dreams examined by Domhoff (2003). A word search analysis of these original dream reports shows that a digital approach can accurately identify many of the same distinctive patterns of content found by previous investigators using much more laborious and time-consuming methods. The results of this study emphasize the compatibility of word search technologies with traditional approaches to dream content analysis. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. Performance analysis of active schedules in identical parallel machine

    Institute of Scientific and Technical Information of China (English)

    Changjun WANG; Yugeng XI

    2007-01-01

    Active schedule is one of the most basic and popular concepts in production scheduling research. For identical parallel machine scheduling with jobs' dynamic arrivals, the tight performance bounds of active schedules under the measurement of four popular objectives are respectively given in this paper. Similar analysis method and conclusions can be generalized to static identical parallel machine and single machine scheduling problem.

  4. Single-cell analysis - Methods and protocols

    Directory of Open Access Journals (Sweden)

    Carlo Alberto Redi

    2013-06-01

    Full Text Available This is certainly a timely volume in the Methods in molecular biology series: we already entered the synthetic biology era and thus we need to be aware of the new methodological advances able to fulfill the new and necessary needs for biologists, biotechnologists and nano-biotechnologists. Notably, among these, the possibility to perform single cell analysis allow researchers to capture single cell responses....

  5. Applied research of environmental monitoring using instrumental neutron activation analysis

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Young Sam; Moon, Jong Hwa; Chung, Young Ju

    1997-08-01

    This technical report is written as a guide book for applied research of environmental monitoring using Instrumental Neutron Activation Analysis. The contents are as followings; sampling and sample preparation as a airborne particulate matter, analytical methodologies, data evaluation and interpretation, basic statistical methods of data analysis applied in environmental pollution studies. (author). 23 refs., 7 tabs., 9 figs.

  6. Text analysis devices, articles of manufacture, and text analysis methods

    Science.gov (United States)

    Turner, Alan E; Hetzler, Elizabeth G; Nakamura, Grant C

    2013-05-28

    Text analysis devices, articles of manufacture, and text analysis methods are described according to some aspects. In one aspect, a text analysis device includes processing circuitry configured to analyze initial text to generate a measurement basis usable in analysis of subsequent text, wherein the measurement basis comprises a plurality of measurement features from the initial text, a plurality of dimension anchors from the initial text and a plurality of associations of the measurement features with the dimension anchors, and wherein the processing circuitry is configured to access a viewpoint indicative of a perspective of interest of a user with respect to the analysis of the subsequent text, and wherein the processing circuitry is configured to use the viewpoint to generate the measurement basis.

  7. A method to measure hydrolytic activity of adenosinetriphosphatases (ATPases.

    Directory of Open Access Journals (Sweden)

    Gianluca Bartolommei

    Full Text Available The detection of small amounts (nanomoles of inorganic phosphate has a great interest in biochemistry. In particular, phosphate detection is useful to evaluate the rate of hydrolysis of phosphatases, that are enzymes able to remove phosphate from their substrate by hydrolytic cleavage. The hydrolysis rate is correlated to enzyme activity, an extremely important functional parameter. Among phosphatases there are the cation transporting adenosinetriphosphatases (ATPases, that produce inorganic phosphate by cleavage of the γ-phosphate of ATP. These membrane transporters have many fundamental physiological roles and are emerging as potential drug targets. ATPase hydrolytic activity is measured to test enzyme functionality, but it also provides useful information on possible inhibitory effects of molecules that interfere with the hydrolytic process. We have optimized a molybdenum-based protocol that makes use of potassium antimony (III oxide tartrate (originally employed for phosphate detection in environmental analysis to allow its use with phosphatase enzymes. In particular, the method was successfully applied to native and recombinant ATPases to demonstrate its reliability, validity, sensitivity and versatility. Our method introduces significant improvements to well-established experimental assays, which are currently employed for ATPase activity measurements. Therefore, it may be valuable in biochemical and biomedical investigations of ATPase enzymes, in combination with more specific tests, as well as in high throughput drug screening.

  8. The Analysis of Activated Carbon Regeneration Technologies

    Institute of Scientific and Technical Information of China (English)

    姚芳

    2014-01-01

    A series of methods for activated carbon regeneration were briefly introduced.Such as thermal regeneration,chemical regeneration,biochemical regeneration,and newly supercritical fluid regeneration, electrochemical regeneration,light-catalyzed regeneration,and microwave radiation method,and the developing trend of activated carbon regeneration was predicted.

  9. Glutarimides: Biological activity, general synthetic methods and physicochemical properties

    Directory of Open Access Journals (Sweden)

    Popović-Đorđević Jelena B.

    2015-01-01

    Full Text Available Glutarimides, 2,6-dioxopiperidines are compounds that rarely occur in natural sources, but so far isolated ones exert widespread pharmacological activities, which makes them valuable as potential pharmacotherapeutics. Glutarimides act as androgen receptor antagonists, anti-inflammatory, anxiolytics, antibacterials, and tumor suppressing agents. Some synthetic glutarimide derivatives are already in use as immunosuppressive and sedative (e.g., thalidomide or anxiolytics (buspirone drugs. The wide applicability of this class of compounds, justify the interest of scientists to explore new pathways for its syntheses. General methods for synthesis of six-membered imide ring, are presented in this paper. These methods include: a reaction of dicarboxylic acids with ammonia or primary amine, b reactions of cyclization: amido-acids, diamides, dinitriles, nitrilo-acids, amido-nitriles, amido-esters, amidoacyl-chlorides or diacyl-chlorides, c adition of carbon-monoxide on a,b-unsaturated amides, d oxidation reactions, e Michael adition of active methylen compounds on methacrylamide or conjugated amides. Some of the described methods are used for closing glutarimide ring in syntheses of farmacological active compounds sesbanimide and aldose reductase inhibitors (ARI. Analyses of the geometry, as well as, the spectroscopic analyses (NMR and FT-IR of some glutarimides are presented because of their broad spectrum of pharmacological activity. To elucidate structures of glutarimides, geometrical parameters of newly synthesized tert-pentyl-1-benzyl-4-methyl-glutarimide-3-carboxylate (PBMG are analyzed and compared with the experimental data from X-ray analysis for glutarimide. Moreover, molecular electrostatic potential (MEP surface which is plotted over the optimized geometry to elucidate the reactivity of PBMG molecule is analyzed. The electronic properties of glutarimide derivatives are explained on the example of thalidomide. The Frontier Molecular Orbital

  10. Space Debris Reentry Analysis Methods and Tools

    Institute of Scientific and Technical Information of China (English)

    WU Ziniu; HU Ruifeng; QU Xi; WANG Xiang; WU Zhe

    2011-01-01

    The reentry of uncontrolled spacecraft may be broken into many pieces of debris at an altitude in the range of 75-85 km.The surviving fragments could pose great hazard and risk to ground and people.In recent years,methods and tools for predicting and analyzing debris reentry and ground risk assessment have been studied and developed in National Aeronautics and Space Administration(NASA),European Space Agency(ESA) and other organizations,including the group of the present authors.This paper reviews the current progress on this topic of debris reentry briefly.We outline the Monte Carlo method for uncertainty analysis,breakup prediction,and parameters affecting survivability of debris.The existing analysis tools can be classified into two categories,i.e.the object-oriented and the spacecraft-oriented methods,the latter being more accurate than the first one.The past object-oriented tools include objects of only simple shapes.For more realistic simulation,here we present an object-oriented tool debris reentry and ablation prediction system(DRAPS) developed by the present authors,which introduces new object shapes to 15 types,as well as 51 predefined motions and relevant aerodynamic and aerothermal models.The aerodynamic and aerothermal models in DRAPS are validated using direct simulation Monte Carlo(DSMC) method.

  11. Optical methods for the analysis of dermatopharmacokinetics

    Science.gov (United States)

    Lademann, Juergen; Weigmann, Hans-Juergen; von Pelchrzim, R.; Sterry, Wolfram

    2002-07-01

    The method of tape stripping in combination with spectroscopic measurements is a simple and noninvasive method for the analysis of dermatopharmacokinetics of cosmetic products and topically applied drugs. The absorbance at 430 nm was used for the characterization of the amount of corneocytes on the tape strips. It was compared to the increase of weight of the tapes after removing them from the skin surface. The penetration profiles of two UV filter substances used in sunscreens were determined. The combined method of tape stripping and spectroscopic measurements can be also used for the investigation of the dermatopharmacokinetics of topically applied drugs passing through the skin. Differences in the penetration profiles of the steroid compound clobetasol, applied in the same concentration in different formulations on the skin are presented.

  12. Data Analysis Methods for Library Marketing

    Science.gov (United States)

    Minami, Toshiro; Kim, Eunja

    Our society is rapidly changing to information society, where the needs and requests of the people on information access are different widely from person to person. Library's mission is to provide its users, or patrons, with the most appropriate information. Libraries have to know the profiles of their patrons, in order to achieve such a role. The aim of library marketing is to develop methods based on the library data, such as circulation records, book catalogs, book-usage data, and others. In this paper we discuss the methodology and imporatnce of library marketing at the beginning. Then we demonstrate its usefulness through some examples of analysis methods applied to the circulation records in Kyushu University and Guacheon Library, and some implication that obtained as the results of these methods. Our research is a big beginning towards the future when library marketing is an unavoidable tool.

  13. [Anorexia nervosa: study method and sleep analysis].

    Science.gov (United States)

    Cervera, S; Zapata, R; Gual, P; Quintanilla, B

    1989-01-01

    By studying anorexia nervosa with an Integrated Inventory and the quality and the quantity of sleep applying Hauri's scale for the analysis of dream contents, the sleeping habits of 50 anorexic patients who were under treatment have been studied. The results show that sleep in these patients is similar and sometimes better in quantity and quality than those in the control group. Their dreams are characterized by an almost total absence of sexual, aggressive and alimentary contents, and that reality, active participation, unpleasant feelings and sensory-perceptive elements are predominant.

  14. A high-efficiency aerothermoelastic analysis method

    Science.gov (United States)

    Wan, ZhiQiang; Wang, YaoKun; Liu, YunZhen; Yang, Chao

    2014-06-01

    In this paper, a high-efficiency aerothermoelastic analysis method based on unified hypersonic lifting surface theory is established. The method adopts a two-way coupling form that couples the structure, aerodynamic force, and aerodynamic thermo and heat conduction. The aerodynamic force is first calculated based on unified hypersonic lifting surface theory, and then the Eckert reference temperature method is used to solve the temperature field, where the transient heat conduction is solved using Fourier's law, and the modal method is used for the aeroelastic correction. Finally, flutter is analyzed based on the p-k method. The aerothermoelastic behavior of a typical hypersonic low-aspect ratio wing is then analyzed, and the results indicate the following: (1) the combined effects of the aerodynamic load and thermal load both deform the wing, which would increase if the flexibility, size, and flight time of the hypersonic aircraft increase; (2) the effect of heat accumulation should be noted, and therefore, the trajectory parameters should be considered in the design of hypersonic flight vehicles to avoid hazardous conditions, such as flutter.

  15. Content Analysis in Systems Engineering Acquisition Activities

    Science.gov (United States)

    2016-04-30

    quantitative and qualitative methods exist to (1) capture or generate data needed for a particular analysis, (2) reduce the data, (3) evaluate the data to...presented in this report was supported by the Acquisition Research Program of the Graduate School of Business & Public Policy at the Naval...analysis in systems engineering technical evaluation processes. Content analysis is a qualitative data analysis methodology used to discover

  16. Numerical analysis method for linear induction machines.

    Science.gov (United States)

    Elliott, D. G.

    1972-01-01

    A numerical analysis method has been developed for linear induction machines such as liquid metal MHD pumps and generators and linear motors. Arbitrary phase currents or voltages can be specified and the moving conductor can have arbitrary velocity and conductivity variations from point to point. The moving conductor is divided into a mesh and coefficients are calculated for the voltage induced at each mesh point by unit current at every other mesh point. Combining the coefficients with the mesh resistances yields a set of simultaneous equations which are solved for the unknown currents.

  17. Thermal Analysis Methods for Aerobraking Heating

    Science.gov (United States)

    Amundsen, Ruth M.; Gasbarre, Joseph F.; Dec, John A.

    2005-01-01

    As NASA begins exploration of other planets, a method of non-propulsively slowing vehicles at the planet, aerobraking, may become a valuable technique for managing vehicle design mass and propellant. An example of this is Mars Reconnaissance Orbiter (MRO), which will launch in late 2005 and reach Mars in March of 2006. In order to save propellant, MRO will use aerobraking to modify the initial orbit at Mars. The spacecraft will dip into the atmosphere briefly on each orbit, and during the drag pass, the atmospheric drag on the spacecraft will slow it, thus lowering the orbit apoapsis. The largest area on the spacecraft, and that most affected by the heat generated during the aerobraking process, is the solar arrays. A thermal analysis of the solar arrays was conducted at NASA Langley, to simulate their performance throughout the entire roughly 6-month period of aerobraking. Several interesting methods were used to make this analysis more rapid and robust. Two separate models were built for this analysis, one in Thermal Desktop for radiation and orbital heating analysis, and one in MSC.Patran for thermal analysis. The results from the radiation model were mapped in an automated fashion to the Patran thermal model that was used to analyze the thermal behavior during the drag pass. A high degree of automation in file manipulation as well as other methods for reducing run time were employed, since toward the end of the aerobraking period the orbit period is short, and in order to support flight operations the runs must be computed rapidly. All heating within the Patran Thermal model was combined in one section of logic, such that data mapped from the radiation model and aeroheating model, as well as skin temperature effects on the aeroheating and surface radiation, could be incorporated easily. This approach calculates the aeroheating at any given node, based on its position and temperature as well as the density and velocity at that trajectory point. Run times on

  18. FUZZY METHOD FOR FAILURE CRITICALITY ANALYSIS

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The greatest benefit is realized from failure mode, effect and criticality analysis (FMECA) when it is done early in the design phase and tracks product changes as they evolve; design changes can then be made more economically than if the problems are discovered after the design has been completed. However, when the discovered design flaws must be prioritized for corrective actions, precise information on their probability of occurrence, the effect of the failure, and their detectability often are not availabe. To solve this problem, this paper described a new method, based on fuzzy sets, for prioritizing failures for corrective actions in a FMCEA. Its successful application to the container crane shows that the proposed method is both reasonable and practical.

  19. Selective spectroscopic methods for water analysis

    Energy Technology Data Exchange (ETDEWEB)

    Vaidya, Bikas [Iowa State Univ., Ames, IA (United States)

    1997-06-24

    This dissertation explores in large part the development of a few types of spectroscopic methods in the analysis of water. Methods for the determination of some of the most important properties of water like pH, metal ion content, and chemical oxygen demand are investigated in detail. This report contains a general introduction to the subject and the conclusions. Four chapters and an appendix have been processed separately. They are: chromogenic and fluorogenic crown ether compounds for the selective extraction and determination of Hg(II); selective determination of cadmium in water using a chromogenic crown ether in a mixed micellar solution; reduction of chloride interference in chemical oxygen demand determination without using mercury salts; structural orientation patterns for a series of anthraquinone sulfonates adsorbed at an aminophenol thiolate monolayer chemisorbed at gold; and the role of chemically modified surfaces in the construction of miniaturized analytical instrumentation.

  20. Analytical methods for arsenic speciation analysis

    Directory of Open Access Journals (Sweden)

    Rajaković Ljubinka V.

    2013-01-01

    Full Text Available Arsenic exists in the form of various chemical species differing by their physicochemical behavior, in toxicity, bioavailability and biotransformation. The determination of arsenic species is an important issue for environmental, clinical and food chemistry. However, differentiation of these species is a quite complex analytical task. Numerous speciation procedures have been studied that include electrochemical, chromatographic, spectrometric and hyphenated techniques. This review comprehends the relevant research in the field of arsenic speciation analysis with novel applications and significant advances. Stability of arsenic species and each of the analytical steps (sample collection, storage, preservation, extraction of the arsenic speciation methods was particularly evaluated. Analytical validation and performance of these methods are also reviewed.

  1. Phase analysis method for burst onset prediction

    Science.gov (United States)

    Stellino, Flavio; Mazzoni, Alberto; Storace, Marco

    2017-02-01

    The response of bursting neurons to fluctuating inputs is usually hard to predict, due to their strong nonlinearity. For the same reason, decoding the injected stimulus from the activity of a bursting neuron is generally difficult. In this paper we propose a method describing (for neuron models) a mechanism of phase coding relating the burst onsets with the phase profile of the input current. This relation suggests that burst onset may provide a way for postsynaptic neurons to track the input phase. Moreover, we define a method of phase decoding to solve the inverse problem and estimate the likelihood of burst onset given the input state. Both methods are presented here in a unified framework, describing a complete coding-decoding procedure. This procedure is tested by using different neuron models, stimulated with different inputs (stochastic, sinusoidal, up, and down states). The results obtained show the efficacy and broad range of application of the proposed methods. Possible applications range from the study of sensory information processing, in which phase-of-firing codes are known to play a crucial role, to clinical applications such as deep brain stimulation, helping to design stimuli in order to trigger or prevent neural bursting.

  2. Metrological activity determination of 133Ba by sum-peak absolute method

    Science.gov (United States)

    da Silva, R. L.; de Almeida, M. C. M.; Delgado, J. U.; Poledna, R.; Santos, A.; de Veras, E. V.; Rangel, J.; Trindade, O. L.

    2016-07-01

    The National Laboratory for Metrology of Ionizing Radiation provides gamma sources of radionuclide and standardized in activity with reduced uncertainties. Relative methods require standards to determine the sample activity while the absolute methods, as sum-peak, not. The activity is obtained directly with good accuracy and low uncertainties. 133Ba is used in research laboratories and on calibration of detectors for analysis in different work areas. Classical absolute methods don't calibrate 133Ba due to its complex decay scheme. The sum-peak method using gamma spectrometry with germanium detector standardizes 133Ba samples. Uncertainties lower than 1% to activity results were obtained.

  3. Metrological activity determination of {sup 133}Ba by sum-peak absolute method

    Energy Technology Data Exchange (ETDEWEB)

    Silva, R.L. da; Delgado, J.U.; Poledna, R.; Santos, A.; Veras, E.V. de; Rangel, J.; Trindade, O.L. [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Almeida, M.C.M. de, E-mail: marcandida@yahoo.com.br, E-mail: candida@cnen.gov.br [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil)

    2015-07-01

    The National Laboratory for Metrology of Ionizing Radiation provides gamma sources of radionuclide and standardized in activity with reduced uncertainties. Relative methods require standards to determine the sample activity while the absolute methods, as sum-peak, not. The activity is obtained directly with good accuracy and low uncertainties. {sup 133}Ba is used in research laboratories and on calibration of detectors for analysis in different work areas. Classical absolute methods do not calibrate {sup 133}Ba due to its complex decay scheme. The sum-peak method using gamma spectrometry with germanium detector standardizes {sup 133}Ba samples. Uncertainties lower than 1% to activity results were obtained.

  4. Application of case analysis teaching method in nursing teaching in Department of Internal Medicine

    Directory of Open Access Journals (Sweden)

    Zhang-xiu SHENG

    2014-04-01

    Full Text Available Objective:In order to adapt to the modern occupation education teaching idea, to stimulate students’ interest in learning, training students' comprehensive quality, improve the students' active participation, understanding, analysis and problem solving skills. Methods: I In the course of different stages using teaching methods of case analysis: case introduction before class teaching method, case analysis during and after class teaching method, and case analysis of the whole chapter after class teaching method.  Results and Conclusion: Through the course of different stages of using case analysis teaching method, we can launch the students’ active learning, stimulate the students' interest in learning, activate classroom atmosphere, train students' independent thinking, strengthen the problems solving ability, improve the self-learning ability of students, activate their participation and awareness, analysis, judgment, introduction, and strengthen students' exam ability, improve the test scores of students and the teaching effect of nursing in Department of internal medicine.

  5. Neutron Activation Analysis of Water - A Review

    Science.gov (United States)

    Buchanan, John D.

    1971-01-01

    Recent developments in this field are emphasized. After a brief review of basic principles, topics discussed include sources of neutrons, pre-irradiation physical and chemical treatment of samples, neutron capture and gamma-ray analysis, and selected applications. Applications of neutron activation analysis of water have increased rapidly within the last few years and may be expected to increase in the future.

  6. Fast and environmentally friendly quantitative analysis of active agents in anti-diabetic tablets by an alternative laser-induced breakdown spectroscopy (LIBS) method and comparison to a validated reversed-phase high-performance liquid chromatography (RP-HPLC) method.

    Science.gov (United States)

    Contreras, Victor Ulises; Meneses-Nava, Marco A; Ornelas-Soto, Nancy; Barbosa-García, Oracio; López-de-Alba, Pedro L; Maldonado, José L; Ramos-Ortiz, Gabriel; Acevedo-Aguilar, Francisco J; López-Martínez, Leticia

    2012-11-01

    Laser-induced breakdown spectroscopy (LIBS) is evaluated as a potential analytic technique for rapid screening and quality control of anti-diabetic tablets. This paper proposes a simple LIBS-based method for the quantitative analysis of two active pharmaceutical ingredients (APIs): metformin (Met) and glybenclamide (Gly). In order to quantify both APIs, chlorine (Cl) concentration was estimated by employing the Cl/Br optical emission ratio, where Br was introduced as internal standard. Calibration curves were prepared, achieving linearity higher than 99%. On the other hand, for comparison to the proposed method, an isocratic reversed-phase high-performance liquid chromatography (RP-HPLC) method was also developed for quantitative determination of the same analytes by ultraviolet (UV) detection. The chromatographic separation was achieved on a Phenomenex Hypersil C18, 250 mm × 4.6 mm, 5 μm column. The mobile phase was K(2)HPO(4)/H(3)PO(4)-CH(3)OH and flow rate was 1.0 mL min(-1). The method is linear over a range of 10-60 μg mL(-1) for Gly and 5-30 μg mL(-1) for Met and the correlation coefficients were ≥0.99. Recoveries were found to be in the range of 95-101%. Furthermore, four different commercial brands of each active agent were evaluated by both proposed LIBS and chromatographic methods and results were compared with each other. The comparison was satisfactorily validated by analysis of variance (ANOVA).

  7. Chemical Component and Activity Analysis of Litsea cubeba Extracts Obtained by Different Extraction Methods%不同提取方法山苍子油的化学成分与抗氧化活性分析

    Institute of Scientific and Technical Information of China (English)

    李芳; Yaru Song; Howard Holness; Kevin O’Shea

    2015-01-01

    山苍子油富含萜烯化合物却显示较低的抗氧化活性(64.95 mg·mL -1 ),色谱级的柠檬醛抗氧化活性最低(74.33 mg·mL -1),因此推测脂肪酸成分(特别是不饱和脂肪酸)是山苍子油抗氧化活性的主要物质基础。%Objective]The objective of this study is to evaluate the effect of three common methods on the DPPH radical scavenging activity and the rate of extraction of Litsea cubeba from the dry fruit. GC-MS analysis was carried out to perform the correlation between chemical composition and antioxidant activity of extracts. [Method]The antioxidant extracts of Litsea cubeba were obtained using liquid-liquid extraction ( with ultrasonic assisted or magnetic assisted) ,SFE ( CO2 super-critical fluid extraction) and steam distillation extraction. The antioxidant activities of the extracts were measured by a free radical scavenging method using 1,1-diphenyl-2-picrylhydrazyl (DPPH). The GC-MS analysis of Litsea cubeba extracts were carried out with added 1,4-dibromobenzene which served as an internal standard. Peak area normalization was used to get the relative amount of main compounds in the respective extracts.[Result]Results demonstrate that the oil has significant antioxidant activity. The natural antioxidants are most effectively extracted by employing liquid – liquid extraction. The ultrasonic assisted liquid-liquid extraction exhibiting the highest oil yields of 26. 34%,while magnetic agitation extraction showed highest antioxidant activity of 31. 22 mg·mL -1(IC50). The antioxidant activity of supercritical carbon dioxide extraction is 56. 95 mg·mL -1 . Steam distillation showed lowest antioxidant activity of 64. 95 mg·mL -1 . More than 122 compounds were identified by GC-MS analysis,including 12 kinds of fatty acids,16 kinds of terpenes,18 kinds of oxygenated terpenes,and other trace compounds including alkenes,alcohols,ketones,and alkanes from these extracts. GC-MS results show that the main components of the oil of Litsea cubeba

  8. A Simple and Accurate Method for Measuring Enzyme Activity.

    Science.gov (United States)

    Yip, Din-Yan

    1997-01-01

    Presents methods commonly used for investigating enzyme activity using catalase and presents a new method for measuring catalase activity that is more reliable and accurate. Provides results that are readily reproduced and quantified. Can also be used for investigations of enzyme properties such as the effects of temperature, pH, inhibitors,…

  9. A Simple and Accurate Method for Measuring Enzyme Activity.

    Science.gov (United States)

    Yip, Din-Yan

    1997-01-01

    Presents methods commonly used for investigating enzyme activity using catalase and presents a new method for measuring catalase activity that is more reliable and accurate. Provides results that are readily reproduced and quantified. Can also be used for investigations of enzyme properties such as the effects of temperature, pH, inhibitors,…

  10. Analysis of methods. [information systems evolution environment

    Science.gov (United States)

    Mayer, Richard J. (Editor); Ackley, Keith A.; Wells, M. Sue; Mayer, Paula S. D.; Blinn, Thomas M.; Decker, Louis P.; Toland, Joel A.; Crump, J. Wesley; Menzel, Christopher P.; Bodenmiller, Charles A.

    1991-01-01

    Information is one of an organization's most important assets. For this reason the development and maintenance of an integrated information system environment is one of the most important functions within a large organization. The Integrated Information Systems Evolution Environment (IISEE) project has as one of its primary goals a computerized solution to the difficulties involved in the development of integrated information systems. To develop such an environment a thorough understanding of the enterprise's information needs and requirements is of paramount importance. This document is the current release of the research performed by the Integrated Development Support Environment (IDSE) Research Team in support of the IISEE project. Research indicates that an integral part of any information system environment would be multiple modeling methods to support the management of the organization's information. Automated tool support for these methods is necessary to facilitate their use in an integrated environment. An integrated environment makes it necessary to maintain an integrated database which contains the different kinds of models developed under the various methodologies. In addition, to speed the process of development of models, a procedure or technique is needed to allow automatic translation from one methodology's representation to another while maintaining the integrity of both. The purpose for the analysis of the modeling methods included in this document is to examine these methods with the goal being to include them in an integrated development support environment. To accomplish this and to develop a method for allowing intra-methodology and inter-methodology model element reuse, a thorough understanding of multiple modeling methodologies is necessary. Currently the IDSE Research Team is investigating the family of Integrated Computer Aided Manufacturing (ICAM) DEFinition (IDEF) languages IDEF(0), IDEF(1), and IDEF(1x), as well as ENALIM, Entity

  11. A concise method for mine soils analysis

    Energy Technology Data Exchange (ETDEWEB)

    Winkler, S.; Wildeman, T.; Robinson, R.; Herron, J.

    1999-07-01

    A large number of abandoned hard rock mines exist in Colorado and other mountain west states, many on public property. Public pressure and resulting policy changes have become a driving force in the reclamation of these sites. Two of the key reclamation issues for these sites in the occurrence of acid forming materials (AFMs) in mine soils, and acid mine drainage (AMD) issuing from mine audits. An AMD treatment system design project for the Forest Queen mine in Colorado's San Juan mountains raised the need for a simple, useable method for analysis of mine land soils, both for suitability as a construction material, and to determine the AFM content and potential for acid release. The authors have developed a simple, stepwise, go - no go test for the analysis of mine soils. Samples were collected from a variety of sites in the Silverton, CO area, and subjected to three tiers of tests including: paste pH, Eh, and 10% HCl fizz test; then total digestion in HNO{sub 3}/HCl, neutralization potential, exposure to meteoric water, and toxicity content leaching procedure (TCLP). All elemental analyses were performed with an inductively-coupled plasma (ICP) spectrometer. Elimination of samples via the first two testing tiers left two remaining samples, which were subsequently subjected to column and sequential batch tests, with further elemental analysis by ICP. Based on these tests, one sample was chosen for suitability as a constructing material for the Forest Queen treatment system basins. Further simplification, and testing on two pairs of independent soil samples, has resulted in a final analytical method suitable for general use.

  12. Chapter 11. Community analysis-based methods

    Energy Technology Data Exchange (ETDEWEB)

    Cao, Y.; Wu, C.H.; Andersen, G.L.; Holden, P.A.

    2010-05-01

    Microbial communities are each a composite of populations whose presence and relative abundance in water or other environmental samples are a direct manifestation of environmental conditions, including the introduction of microbe-rich fecal material and factors promoting persistence of the microbes therein. As shown by culture-independent methods, different animal-host fecal microbial communities appear distinctive, suggesting that their community profiles can be used to differentiate fecal samples and to potentially reveal the presence of host fecal material in environmental waters. Cross-comparisons of microbial communities from different hosts also reveal relative abundances of genetic groups that can be used to distinguish sources. In increasing order of their information richness, several community analysis methods hold promise for MST applications: phospholipid fatty acid (PLFA) analysis, denaturing gradient gel electrophoresis (DGGE), terminal restriction fragment length polymorphism (TRFLP), cloning/sequencing, and PhyloChip. Specific case studies involving TRFLP and PhyloChip approaches demonstrate the ability of community-based analyses of contaminated waters to confirm a diagnosis of water quality based on host-specific marker(s). The success of community-based MST for comprehensively confirming fecal sources relies extensively upon using appropriate multivariate statistical approaches. While community-based MST is still under evaluation and development as a primary diagnostic tool, results presented herein demonstrate its promise. Coupled with its inherently comprehensive ability to capture an unprecedented amount of microbiological data that is relevant to water quality, the tools for microbial community analysis are increasingly accessible, and community-based approaches have unparalleled potential for translation into rapid, perhaps real-time, monitoring platforms.

  13. Methods of Modelling Marketing Activity on Software Sales

    Directory of Open Access Journals (Sweden)

    Bashirov Islam H.

    2013-11-01

    Full Text Available The article studies a topical issue of development of methods of modelling marketing activity on software sales for achievement of efficient functioning of an enterprise. On the basis of analysis of the market type for the studied CloudLinux OS product, the article identifies the market structure type: monopolistic competition. To ensure the information basis of the marketing activity in the target market segment, the article offers the survey method. The article provides a questionnaire, which contains specific questions regarding the studied market segment of hosting services, for an online survey with the help of the Survio service. In accordance with the system approach the CloudLinux OS has properties of systems, namely, diversity. Economic differences are non-price indicators that have no numeric expression and are quality descriptions. Analysis of the market and the conducted survey allow obtaining them. Combination of price and non-price indicators provides a complete description of the product properties. To calculate an integral indicator of competitiveness the article offers to apply a model, which is based on the direct algebraic addition of weight measures of individual indicators, regulation of formalised indicators and use of the mechanism of fuzzy sets for identification of non-formalised indicators. The calculated indicator allows not only assessment of the current level of competitiveness, but also identification of influence of changes of various indicators, which allows increase of efficiency of marketing decisions. Also, having identified the target customers of hosting OS and formalised non-price parameters, it is possible to conduct the search for a set of optimal characteristics of the product. In the result an optimal strategy of the product advancement to the market is formed.

  14. High resolution N2 adsorption isotherms at 77.4 K and 87.3 K by carbon blacks and activated carbon fibers--analysis of porous texture of activated carbon fibers by αs-method.

    Science.gov (United States)

    Nakai, Kazuyuki; Nakada, Yoko; Hakuman, Masako; Yoshida, Masayuki; Senda, Yousuke; Tateishi, Yuko; Sonoda, Joji; Naono, Hiromitsu

    2012-02-01

    The standard α(s)-data of N(2) at 87.3 K by graphitized and nongraphitized carbon black samples (GCB-I and NGCB) (cf.Figs. 3 and 4) have been determined on the basis of the high resolution adsorption isotherms of N(2) at 87.3 K, which were repeatedly measured in the pressure range of p/p(o)=5×10(-8)-0.4. The high resolution adsorption isotherms of N(2) by two kinds of activated carbon fibers (ACF-I and ACF-II) were measured from p/p(o)=10(-7) to p/p(o)=0.995 at 77.4 K and from p/p(o)=10(-7) to p/p(o)=0.4 at 87.3 K. Combination of the adsorption isotherms by ACF-I and ACF-II with the standard α(s)-data by NGCB at 77.4 K and 87.3 K make it possible to construct the high resolution α(s)-plots from very low filling (1%) to complete filling (100%). The high resolution α(s)-plots of N(2) at 77.4 K and 87.3 K were analyzed. On the basis of the analyzed result, the porous textures of ACF-I and ACF-II will be discussed.

  15. Generalized Analysis of a Distribution Separation Method

    Directory of Open Access Journals (Sweden)

    Peng Zhang

    2016-04-01

    Full Text Available Separating two probability distributions from a mixture model that is made up of the combinations of the two is essential to a wide range of applications. For example, in information retrieval (IR, there often exists a mixture distribution consisting of a relevance distribution that we need to estimate and an irrelevance distribution that we hope to get rid of. Recently, a distribution separation method (DSM was proposed to approximate the relevance distribution, by separating a seed irrelevance distribution from the mixture distribution. It was successfully applied to an IR task, namely pseudo-relevance feedback (PRF, where the query expansion model is often a mixture term distribution. Although initially developed in the context of IR, DSM is indeed a general mathematical formulation for probability distribution separation. Thus, it is important to further generalize its basic analysis and to explore its connections to other related methods. In this article, we first extend DSM’s theoretical analysis, which was originally based on the Pearson correlation coefficient, to entropy-related measures, including the KL-divergence (Kullback–Leibler divergence, the symmetrized KL-divergence and the JS-divergence (Jensen–Shannon divergence. Second, we investigate the distribution separation idea in a well-known method, namely the mixture model feedback (MMF approach. We prove that MMF also complies with the linear combination assumption, and then, DSM’s linear separation algorithm can largely simplify the EM algorithm in MMF. These theoretical analyses, as well as further empirical evaluation results demonstrate the advantages of our DSM approach.

  16. Water Hammer Analysis by Characteristic Method

    Directory of Open Access Journals (Sweden)

    A. R. Lohrasbi

    2008-01-01

    Full Text Available Rapid changes in the velocity of fluid in closed conduits generate large pressure, which are transmitted through the system with the speed of sound. When the fluid medium is a liquid the pressure surges and related phenomena are described as water hammer. Water hammer is caused by normal operation of the system, such as valve opening or closure, pump starts and stoppages and by abnormal condition, such as power failure. Problem statement: Water hammer causes the additional pressure in water networks. This pressure maybe defects on pipes and connections. The likely effects of water hammer must be taken into account in the structural design of pipelines and in the design of operating procedures for pumps, valves, etc. Approach: The physical phenomena of water hammer and the mathematical model which provides the basis for design computations are described. Most water hammer analysis involves computer solution by the method of characteristics. In this study water hammer is modelled with this method and effect of valve opening and closure will be surveyed with a program that is used for this purpose and with a numerical example. Results: The more rapid the closure of the valve, the more rapid is the change in momentum and hence, greater is the additional pressure developed. Conclusions/Recommendations: For preventing of water hammer defects, is recommended that valves should be open or closed slowly. Also with using the method of characteristics, we can modelled all pipe networks, and see the affects of water hammer.

  17. Spatial methods in areal administrative data analysis

    Directory of Open Access Journals (Sweden)

    Haijun Ma

    2006-12-01

    Full Text Available Administrative data often arise as electronic copies of paid bills generated from insurance companies including the Medicare and Medicaid programs. Such data are widely seen and analyzed in the public health area, as in investigations of cancer control, health service accessibility, and spatial epidemiology. In areas like political science and education, administrative data are also important. Administrative data are sometimes more readily available as summaries over each administrative unit (county, zip code, etc. in a particular set determined by geopolitical boundaries, or what statisticians refer to as areal data. However, the spatial dependence often present in administrative data is often ignored by health services researchers. This can lead to problems in estimating the true underlying spatial surface, including inefficient use of data and biased conclusions. In this article, we review hierarchical statistical modeling and boundary analysis (wombling methods for areal-level spatial data that can be easily carried out using freely available statistical computing packages. We also propose a new edge-domain method designed to detect geographical boundaries corresponding to abrupt changes in the areal-level surface. We illustrate our methods using county-level breast cancer late detection data from the state of Minnesota.

  18. Analysis Method for Quantifying Vehicle Design Goals

    Science.gov (United States)

    Fimognari, Peter; Eskridge, Richard; Martin, Adam; Lee, Michael

    2007-01-01

    A document discusses a method for using Design Structure Matrices (DSM), coupled with high-level tools representing important life-cycle parameters, to comprehensively conceptualize a flight/ground space transportation system design by dealing with such variables as performance, up-front costs, downstream operations costs, and reliability. This approach also weighs operational approaches based on their effect on upstream design variables so that it is possible to readily, yet defensively, establish linkages between operations and these upstream variables. To avoid the large range of problems that have defeated previous methods of dealing with the complex problems of transportation design, and to cut down the inefficient use of resources, the method described in the document identifies those areas that are of sufficient promise and that provide a higher grade of analysis for those issues, as well as the linkages at issue between operations and other factors. Ultimately, the system is designed to save resources and time, and allows for the evolution of operable space transportation system technology, and design and conceptual system approach targets.

  19. Recent Developments in Helioseismic Analysis Methods and Solar Data Assimilation

    CERN Document Server

    Schad, Ariane; Duvall, Tom L; Roth, Markus; Vorontsov, Sergei V

    2016-01-01

    We review recent advances and results in enhancing and developing helioseismic analysis methods and in solar data assimilation. In the first part of this paper we will focus on selected developments in time-distance and global helioseismology. In the second part, we review the application of data assimilation methods on solar data. Relating solar surface observations as well as helioseismic proxies with solar dynamo models by means of the techniques from data assimilation is a promising new approach to explore and to predict the magnetic activity cycle of the Sun.

  20. Research on the Dividing Method for Present-Day Regional Active Block

    Institute of Scientific and Technical Information of China (English)

    Zhang Xiaoliang; Jiang Zaisen; Chen Bing; Wang Qi; Zhang Xi

    2006-01-01

    In this paper, a new idea that combines Quasi-Accurate Detection of gross errors (QUAD) with discontinuous deformation positive analysis, is brought forward to divide the regional active blocks. The method can improve the demarcation of active blocks for areas lacking with observation data and offer a new train of through for the complete study of the regional deformation of active blocks. In addition, using the Sichuan-Yunnan area as example, the practice process of the method is introduced briefly.

  1. Multi-Spacecraft Turbulence Analysis Methods

    Science.gov (United States)

    Horbury, Tim S.; Osman, Kareem T.

    Turbulence is ubiquitous in space plasmas, from the solar wind to supernova remnants, and on scales from the electron gyroradius to interstellar separations. Turbulence is responsible for transporting energy across space and between scales and plays a key role in plasma heating, particle acceleration and thermalisation downstream of shocks. Just as with other plasma processes such as shocks or reconnection, turbulence results in complex, structured and time-varying behaviour which is hard to measure with a single spacecraft. However, turbulence is a particularly hard phenomenon to study because it is usually broadband in nature: it covers many scales simultaneously. One must therefore use techniques to extract information on multiple scales in order to quantify plasma turbulence and its effects. The Cluster orbit takes the spacecraft through turbulent regions with a range of characteristics: the solar wind, magnetosheath, cusp and magnetosphere. In each, the nature of the turbulence (strongly driven or fully evolved; dominated by kinetic effects or largely on fluid scales), as well as characteristics of the medium (thermalised or not; high or low plasma sub- or super-Alfvenic) mean that particular techniques are better suited to the analysis of Cluster data in different locations. In this chapter, we consider a range of methods and how they are best applied to these different regions. Perhaps the most studied turbulent space plasma environment is the solar wind, see Bruno and Carbone [2005]; Goldstein et al. [2005] for recent reviews. This is the case for a number of reasons: it is scientifically important for cosmic ray and solar energetic particle scattering and propagation, for example. However, perhaps the most significant motivations for studying solar wind turbulence are pragmatic: large volumes of high quality measurements are available; the stability of the solar wind on the scales of hours makes it possible to identify statistically stationary intervals to

  2. Operating cost analysis of anaesthesia: Activity based costing (ABC analysis

    Directory of Open Access Journals (Sweden)

    Majstorović Branislava M.

    2011-01-01

    Full Text Available Introduction. Cost of anaesthesiology represent defined measures to determine a precise profile of expenditure estimation of surgical treatment, which is important regarding planning of healthcare activities, prices and budget. Objective. In order to determine the actual value of anaestesiological services, we started with the analysis of activity based costing (ABC analysis. Methods. Retrospectively, in 2005 and 2006, we estimated the direct costs of anestesiological services (salaries, drugs, supplying materials and other: analyses and equipment. of the Institute of Anaesthesia and Resuscitation of the Clinical Centre of Serbia. The group included all anesthetized patients of both sexes and all ages. We compared direct costs with direct expenditure, “each cost object (service or unit” of the Republican Health-care Insurance. The Summary data of the Departments of Anaesthesia documented in the database of the Clinical Centre of Serbia. Numerical data were utilized and the numerical data were estimated and analyzed by computer programs Microsoft Office Excel 2003 and SPSS for Windows. We compared using the linear model of direct costs and unit costs of anaesthesiological services from the Costs List of the Republican Health-care Insurance. Results. Direct costs showed 40% of costs were spent on salaries, (32% on drugs and supplies, and 28% on other costs, such as analyses and equipment. The correlation of the direct costs of anaestesiological services showed a linear correlation with the unit costs of the Republican Healthcare Insurance. Conclusion. During surgery, costs of anaesthesia would increase by 10% the surgical treatment cost of patients. Regarding the actual costs of drugs and supplies, we do not see any possibility of costs reduction. Fixed elements of direct costs provide the possibility of rationalization of resources in anaesthesia.

  3. Bayesian methods for the design and analysis of noninferiority trials.

    Science.gov (United States)

    Gamalo-Siebers, Margaret; Gao, Aijun; Lakshminarayanan, Mani; Liu, Guanghan; Natanegara, Fanni; Railkar, Radha; Schmidli, Heinz; Song, Guochen

    2016-01-01

    The gold standard for evaluating treatment efficacy of a medical product is a placebo-controlled trial. However, when the use of placebo is considered to be unethical or impractical, a viable alternative for evaluating treatment efficacy is through a noninferiority (NI) study where a test treatment is compared to an active control treatment. The minimal objective of such a study is to determine whether the test treatment is superior to placebo. An assumption is made that if the active control treatment remains efficacious, as was observed when it was compared against placebo, then a test treatment that has comparable efficacy with the active control, within a certain range, must also be superior to placebo. Because of this assumption, the design, implementation, and analysis of NI trials present challenges for sponsors and regulators. In designing and analyzing NI trials, substantial historical data are often required on the active control treatment and placebo. Bayesian approaches provide a natural framework for synthesizing the historical data in the form of prior distributions that can effectively be used in design and analysis of a NI clinical trial. Despite a flurry of recent research activities in the area of Bayesian approaches in medical product development, there are still substantial gaps in recognition and acceptance of Bayesian approaches in NI trial design and analysis. The Bayesian Scientific Working Group of the Drug Information Association provides a coordinated effort to target the education and implementation issues on Bayesian approaches for NI trials. In this article, we provide a review of both frequentist and Bayesian approaches in NI trials, and elaborate on the implementation for two common Bayesian methods including hierarchical prior method and meta-analytic-predictive approach. Simulations are conducted to investigate the properties of the Bayesian methods, and some real clinical trial examples are presented for illustration.

  4. Method and tool for network vulnerability analysis

    Science.gov (United States)

    Swiler, Laura Painton; Phillips, Cynthia A.

    2006-03-14

    A computer system analysis tool and method that will allow for qualitative and quantitative assessment of security attributes and vulnerabilities in systems including computer networks. The invention is based on generation of attack graphs wherein each node represents a possible attack state and each edge represents a change in state caused by a single action taken by an attacker or unwitting assistant. Edges are weighted using metrics such as attacker effort, likelihood of attack success, or time to succeed. Generation of an attack graph is accomplished by matching information about attack requirements (specified in "attack templates") to information about computer system configuration (contained in a configuration file that can be updated to reflect system changes occurring during the course of an attack) and assumed attacker capabilities (reflected in "attacker profiles"). High risk attack paths, which correspond to those considered suited to application of attack countermeasures given limited resources for applying countermeasures, are identified by finding "epsilon optimal paths."

  5. Digital methods for mediated discourse analysis

    DEFF Research Database (Denmark)

    Kjær, Malene; Larsen, Malene Charlotte

    2015-01-01

    practice of health care professionals (Author 1, 2014) and 2) young people’s identity construction on social media platforms (Author 2, 2010, 2015, in press). The paper’s contribution is a methodological discussion on digital data collection using methods such as online interviewing (via e-mail or chat......In this paper we discuss methodological strategies for collecting multimodal data using digital resources. The aim is to show how digital resources can provide ethnographic insights into mediated actions (Scollon, 2002) that can otherwise be difficult to observe or engage in, due to, for instance......, restrictions or privately mediated settings. Having used mediated discourse analysis (Scollon 2002, Scollon & Scollon, 2004) as a framework in two different research projects, we show how the framework, in correlation with digital resources for data gathering, provides new understandings of 1) the daily...

  6. Quantitative Risk Analysis: Method And Process

    Directory of Open Access Journals (Sweden)

    Anass BAYAGA

    2010-03-01

    Full Text Available Recent and past studies (King III report, 2009: 73-75; Stoney 2007;Committee of Sponsoring Organisation-COSO, 2004, Bartell, 2003; Liebenberg and Hoyt, 2003; Reason, 2000; Markowitz 1957 lament that although, the introduction of quantifying risk to enhance degree of objectivity in finance for instance was quite parallel to its development in the manufacturing industry, it is not the same in Higher Education Institution (HEI. In this regard, the objective of the paper was to demonstrate the methods and process of Quantitative Risk Analysis (QRA through likelihood of occurrence of risk (phase I. This paper serves as first of a two-phased study, which sampled hundred (100 risk analysts in a University in the greater Eastern Cape Province of South Africa.The analysis of likelihood of occurrence of risk by logistic regression and percentages were conducted to investigate whether there were a significant difference or not between groups (analyst in respect of QRA.The Hosmer and Lemeshow test was non-significant with a chi-square(X2 =8.181; p = 0.300, which indicated that there was a good model fit, since the data did not significantly deviate from the model. The study concluded that to derive an overall likelihood rating that indicated the probability that a potential risk may be exercised within the construct of an associated threat environment, the following governing factors must be considered: (1 threat source motivation and capability (2 nature of the vulnerability (3 existence and effectiveness of current controls (methods and process.

  7. Teacher’s methodical activity as a source of educational and methodical tasks

    Directory of Open Access Journals (Sweden)

    Скворцова С. А.

    2016-09-01

    Full Text Available The article of S. Skvortsova “Teacher’s methodical activity as a source of educational and methodical tasks”, interprets the teacher’s methodical activity as solving a number of methodical tasks. We define a methodical task as a situation that occurs in the process of teacher's methodical activity the purpose of which is to teach pupils certain content. Educational and methodical tasks are the models of such situations formulated in words. The goal of educational and methodical tasks is to form future teachers’ methodical competency. Methodical tasks are classified on practical and intellectual, that in its turn are divided into standard and problematic. Taking into consideration the external structure of the process of solving methodical tasks we define the teacher’s ability to solve methodical tasks as a complex of actions to be performed to solve a methodical task on the basis of a teacher’s conscious use of methodical knowledge and ways of action. Educational and methodical tasks are used in order to form the ability to solve methodical tasks in the process of teacher’s methodical training in pedagogical universities. Educational and methodical tasks, as opposed to methodical tasks, are classified: 1 according to the level of methodical activity on standard, partially-standard and creative; 2 according to the types of methodical activity on informational-analytical, analytically-synthetic, operationally-practical, projective-modelling, synthetic-constructing; 3 according to the content of teacher’s methodical activity on basic and special ones. Standard and partially-standard educational and methodical tasks are the symbolic models of standard methodical tasks in teacher’s activity, and creative educational and methodical tasks are the symbolic models of problematic methodical tasks. Educational and methodical tasks are mainly the models of intellectual methodical tasks as they don’t suggest the interaction between a

  8. Buckling analysis of composite cylindrical shell using numerical analysis method

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Hae Young; Bae, Won Byung [Pusan Nat' l Univ., Busan (Korea, Republic of); Cho, Jong Rae [Korea Maritime Univ., Busan (Korea, Republic of); Lee, Woo Hyung [Underwater Vehicle Research Center, Busan (Korea, Republic of)

    2012-01-15

    The objective of this paper is to predict the buckling pressure of a composite cylindrical shell using buckling formulas (ASME 2007, NASA SP 8007) and finite element analysis. The model in this study uses a stacking angle of [0/90]12t and USN 125 composite material. All specimens were made using a prepreg method. First, finite element analysis was conducted, and the results were verified through comparison with the hydrostatic pressure bucking experiment results. Second, the values obtained from the buckling formula and the buckling pressure values obtained from the finite element analysis were compared as the stacking angle was changed in 5 .deg. increments from 20 .deg. to 90 .deg. The linear and nonlinear results of the finite element analysis were consistent with the results of the experiment, with a safety factor of 0.85-1. Based on the above result, the ASME 2007 formula, a simplified version of the NASA SP 8007 formula, is regarded as a buckling formula that provides a reliable safety factor.

  9. An active vibration isolation system using adaptive proportional control method

    Science.gov (United States)

    Liu, Yun-Hui; Hsieh, Hung-En; Wu, Wei-Hao

    2014-03-01

    This paper is concerned with a six-degree-of-freedom active vibration isolation system using voice coil actuators with absolute velocity feedback control for highly sensitive measurement equipment, e.g. atomic force microscopes, suffering from building vibration. The main differences between this type of system and traditional isolator, is that there are no isolator resonance. The absolute vibration velocity signal acquired from an accelerator and being processed through an integrator is input to the controller as a feedback signal, and the controller output signal drives the voice coil actuator to produce a sky-hook damper force. In practice, the phase response of integrator at low frequency such as 2~6 Hz deviate from the 90 degree which is the exact phase difference between the vibration velocity and acceleration. Therefore, an adaptive filter is used to compensate the phase error in this paper. An analysis of this active vibration isolation system is presented, and model predictions are compared to experimental results. The results show that the proposed method significantly reduces transmissibility at resonance without the penalty of increased transmissibility at higher frequencies.

  10. Analysis on electric energy measuring method based on multi-resolution analysis

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xiao-bing; CUI Jia-rui; LIANG Yuan-hua; WANG Mu-kun

    2006-01-01

    Along with the massive applications of the non-linear loads and the impact loads, many non-stationary stochastic signals such as harmonics, inter-harmonics, impulse signals and so on are introduced into the electric network, and these non-stationary stochastic signals have had effects on the accuracy of the measurement of electric energy. The traditional method like Fourier Analysis can be applied efficiently on the stationary stochastic signals, but it has little effect on non-stationary stochastic signals. In light of this, the form of the signals of the electric network in wavelet domain will be discussed in this paper. A measurement method of active power based on multi-resolution analysis in the stochastic process is presented. This method has a wider application scope compared with the traditional method Fourier analysis, and it is of good referential value and practical value in terms of raising the level of the existing electric energy measurement.

  11. Current status of neutron activation analysis using the Dalat Nuclear Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen Van Suc; Nguyen Mong Sinh [Nuclear Research Institute, Dalat (Viet Nam)

    1999-10-01

    Neutron activation analysis is one of the most sensitive, rapid, accurated methods for determination of trace elements in different materials. A review is made of the current status of the activities and the results in studying and developing NAA (Neutron Activation Analysis) at the Dalat Nuclear Research Institute and applying this method to different sectors of science and technology in Vietnam. (author)

  12. Noninvasive method to assess the electrical brain activity from rats

    Directory of Open Access Journals (Sweden)

    Rosana Ferrari

    2013-10-01

    Full Text Available This research presents a noninvasive method for the acquisition of brain electrical signal in rat. Was used an electroencephalography (EEG system developed for bovine and adapted to rats. The bipolar electrode system (needle electrodes was glued on the surface of the head of the animal without surgical procedures and the other electrode was glued to the tail, as ground. The EEG activity was sampled at 120Hz for an hour. The accuracy and precision of the EEG measurement was performed using Fourier analysis and signal energy. For this, the digital signal was divided into sections successive of 3 seconds and was decomposed into four frequency bands: delta (0.3 to 4Hz, theta (4-8Hz, alpha (8-12Hz and beta (12-30Hz and energy (µV² of the series of time filtered were calculated. The method allowed the acquisition of non-invasive electrical brain signals in conscious rats and their frequency patterns were in agreement with previous studies that used surgical procedures to acquire EEG in rats. This system showed accuracy and precision and will allow further studies on behavior and to investigate the action of drugs on the central nervous system in rats without surgical procedures.

  13. Social activity method (SAM): A fractal language for mathematics

    Science.gov (United States)

    Dowling, Paul

    2013-09-01

    In this paper I shall present and develop my organisational language, social activity method (SAM), and illustrate some of its applications. I shall introduce a new scheme for modes of recontextualisation that enables the analysis of the ways in which one activity - which might be school mathematics or social research or any empirically observed regularity of practice - recontextualises the practice of another and I shall also present, deploy, and develop an existing scheme - domains of action - in an analysis of school mathematics examination papers and in the structuring of what I refer to as the esoteric domain. This domain is here conceived as a hybrid domain of, first, linguistic and extralinguistic resources that are unambiguously mathematical in terms of both expression and content and, second, pedagogic theory - often tacit - that enables the mathematical gaze onto other practices and so recontextualises them. A second and more general theme that runs through the paper is the claim that there is nothing that is beyond semiosis, that there is nothing to which we have direct access, unmediated by interpretation. This state of affairs has implications for mathematics education. Specifically, insofar as an individual's mathematical semiotic system is under continuous development - the curriculum never being graspable all at once - understanding - as a stable semiotic moment - of any aspect or object of mathematics is always localised to the individual and is at best transient, and the sequencing of such moments may well also be more individualised than consistent in some correspondence with the sequencing of the curriculum. This being the case, a concentration on understanding as a goal may well serve to inhibit the pragmatic acquisition and deployment of mathematical technologies, which should be the principal aim of mathematics teaching and learning. The paper is primarily concerned with mathematics education. SAM, however, is a language that is available for

  14. Coloured Petri Nets: Basic Concepts, Analysis Methods and Practical Use. Vol. 2, Analysis Methods

    DEFF Research Database (Denmark)

    Jensen, Kurt

    This three-volume work presents a coherent description of the theoretical and practical aspects of coloured Petri nets (CP-nets). The second volume contains a detailed presentation of the analysis methods for CP-nets. They allow the modeller to investigate dynamic properties of CP-nets. The main...

  15. Methods to Measure Physical Activity Behaviors in Health Education Research

    Science.gov (United States)

    Fitzhugh, Eugene C.

    2015-01-01

    Regular physical activity (PA) is an important concept to measure in health education research. The health education researcher might need to measure physical activity because it is the primary measure of interest, or PA might be a confounding measure that needs to be controlled for in statistical analysis. The purpose of this commentary is to…

  16. Specific classification of financial analysis of enterprise activity

    Directory of Open Access Journals (Sweden)

    Synkevych Nadiia I.

    2014-01-01

    Full Text Available Despite the fact that one can find a big variety of classifications of types of financial analysis of enterprise activity, which differ with their approach to classification and a number of classification features and their content, in modern scientific literature, their complex comparison and analysis of existing classification have not been done. This explains urgency of this study. The article studies classification of types of financial analysis of scientists and presents own approach to this problem. By the results of analysis the article improves and builds up a specific classification of financial analysis of enterprise activity and offers classification by the following features: objects, subjects, goals of study, automation level, time period of the analytical base, scope of study, organisation system, classification features of the subject, spatial belonging, sufficiency, information sources, periodicity, criterial base, method of data selection for analysis and time direction. All types of financial analysis significantly differ with their inherent properties and parameters depending on the goals of financial analysis. The developed specific classification provides subjects of financial analysis of enterprise activity with a possibility to identify a specific type of financial analysis, which would correctly meet the set goals.

  17. An active vibration control method of bridge structures by the ...

    African Journals Online (AJOL)

    An active vibration control method of bridge structures by the linearization of ... zones due to economic requirements, and with occurrence of seismic events in ... linearization proportionality coefficients are constantly modified to optimal values.

  18. An Overview of Bayesian Methods for Neural Spike Train Analysis

    Directory of Open Access Journals (Sweden)

    Zhe Chen

    2013-01-01

    Full Text Available Neural spike train analysis is an important task in computational neuroscience which aims to understand neural mechanisms and gain insights into neural circuits. With the advancement of multielectrode recording and imaging technologies, it has become increasingly demanding to develop statistical tools for analyzing large neuronal ensemble spike activity. Here we present a tutorial overview of Bayesian methods and their representative applications in neural spike train analysis, at both single neuron and population levels. On the theoretical side, we focus on various approximate Bayesian inference techniques as applied to latent state and parameter estimation. On the application side, the topics include spike sorting, tuning curve estimation, neural encoding and decoding, deconvolution of spike trains from calcium imaging signals, and inference of neuronal functional connectivity and synchrony. Some research challenges and opportunities for neural spike train analysis are discussed.

  19. New numerical analysis method in computational mechanics: composite element method

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A new type of FEM, called CEM (composite element method), is proposed to solve the static and dynamic problems of engineering structures with high accuracy and efficiency. The core of this method is to define two sets of coordinate systems for DOF's description after discretizing the structure, i.e. the nodal coordinate system UFEM(ξ) for employing the conventional FEM, and the field coordinate system UCT(ξ) for utilizing classical theory. Then, coupling these two sets of functional expressions could obtain the composite displacement field U(ξ) of CEM. The computations of the stiffness and mass matrices can follow the conventional procedure of FEM. Since the CEM inherents some good properties of the conventional FEM and classical analytical method, it has the powerful versatility to various complex geometric shapes and excellent approximation. Many examples are presented to demonstrate the ability of CEM.

  20. New numerical analysis method in computational mechanics: composite element method

    Institute of Scientific and Technical Information of China (English)

    曾攀

    2000-01-01

    A new type of FEM, called CEM (composite element method), is proposed to solve the static and dynamic problems of engineering structures with high accuracy and efficiency. The core of this method is to define two sets of coordinate systems for DOF’ s description after discretizing the structure, i.e. the nodal coordinate system UFEM(ζ) for employing the conventional FEM, and the field coordinate system UCT(ζ) for utilizing classical theory. Then, coupling these two sets of functional expressions could obtain the composite displacement field U(ζ) of CEM. The computations of the stiffness and mass matrices can follow the conventional procedure of FEM. Since the CEM inherents some good properties of the conventional FEM and classical analytical method, it has the powerful versatility to various complex geometric shapes and excellent approximation. Many examples are presented to demonstrate the ability of CEM.

  1. Methods for the proximate analysis of peat

    Energy Technology Data Exchange (ETDEWEB)

    Sheppard, J.D.; Tibbetts, T.E.; Forgeron, D.W.

    1986-01-01

    An investigation was conducted into methods for determining the percentages of volatile matter and ash in peat. Experiments were performed on two types of sphagnum peat, a decomposed fuel peat and a commercial horticultural grade peat. The heating apparatus consisted of both a standard programmable furnace (Fisher Coal Analyser) and a thermogravimetric analyser with a module for differential scanning calorimetry (Mettler TA 3000 system). The results indicate that the seven minute test for volatile matter at either 900 C or 950 C does not fully differentiate volatiles from fixed carbon and, depending on the degree of decomposition, up to sixty minutes at 900 C may be required. The TGA system is very useful in discriminating between different fractions of volatile matter. The relative fractions are more important in determining burning characteristics than the total percentage of volatiles. Ashing must be performed under conditions sufficiently severe to ensure complete combustion of organics. The severity that is required is mainly dependent on the degree of decomposition and sample size. Use of TGA and DSC for studying the combustion of peat provides much more information than the standard proximate analysis. 14 refs.

  2. Mapping Cigarettes Similarities using Cluster Analysis Methods

    Directory of Open Access Journals (Sweden)

    Lorentz Jäntschi

    2007-09-01

    Full Text Available The aim of the research was to investigate the relationship and/or occurrences in and between chemical composition information (tar, nicotine, carbon monoxide, market information (brand, manufacturer, price, and public health information (class, health warning as well as clustering of a sample of cigarette data. A number of thirty cigarette brands have been analyzed. Six categorical (cigarette brand, manufacturer, health warnings, class and four continuous (tar, nicotine, carbon monoxide concentrations and package price variables were collected for investigation of chemical composition, market information and public health information. Multiple linear regression and two clusterization techniques have been applied. The study revealed interesting remarks. The carbon monoxide concentration proved to be linked with tar and nicotine concentration. The applied clusterization methods identified groups of cigarette brands that shown similar characteristics. The tar and carbon monoxide concentrations were the main criteria used in clusterization. An analysis of a largest sample could reveal more relevant and useful information regarding the similarities between cigarette brands.

  3. An Analysis of the SURF Method

    Directory of Open Access Journals (Sweden)

    Edouard Oyallon

    2015-07-01

    Full Text Available The SURF method (Speeded Up Robust Features is a fast and robust algorithm for local, similarity invariant representation and comparison of images. Similarly to many other local descriptor-based approaches, interest points of a given image are defined as salient features from a scale-invariant representation. Such a multiple-scale analysis is provided by the convolution of the initial image with discrete kernels at several scales (box filters. The second step consists in building orientation invariant descriptors, by using local gradient statistics (intensity and orientation. The main interest of the SURF approach lies in its fast computation of operators using box filters, thus enabling real-time applications such as tracking and object recognition. The SURF framework described in this paper is based on the PhD thesis of H. Bay [ETH Zurich, 2009], and more specifically on the paper co-written by H. Bay, A. Ess, T. Tuytelaars and L. Van Gool [Computer Vision and Image Understanding, 110 (2008, pp. 346–359]. An implementation is proposed and used to illustrate the approach for image matching. A short comparison with a state-of-the-art approach is also presented, the SIFT algorithm of D. Lowe [International Journal of Computer Vision, 60 (2004, pp. 91–110], with which SURF shares a lot in common.

  4. The methodical statutes monitoring of activity by innovative structures

    OpenAIRE

    Stoianovskii, Andrii; Baranovska, Sofia; Stoianovska, Iryna

    2012-01-01

    In the article it is suggested to perfect methodical recommendations in relation to monitoring of activity of innovative structures, which, among other, allow to mark off the results of activity of leading organ of management and contractors of innovative projects, registered in her limits an innovative structure.

  5. [Methods of hygromycin B phosphotransferase activity assay in transgenic plant].

    Science.gov (United States)

    Zhuo, Qin; Yang, Xiaoguang

    2004-07-01

    Hygromycin B phosphotransferase (HPT) is a widely used selectable marker protein of transgenic plant. Detection of its activity is critical to studies on the development of various transgenic plants, silence of inserted gene, marker-free system development and safety assessment of transgenic food. In this paper, several methods for detecting the activity of this enzyme were reviewed.

  6. Forms and Methods of Agricultural Sector Innovative Activity Improvement

    Directory of Open Access Journals (Sweden)

    Aisha S. Ablyaeva

    2013-01-01

    Full Text Available The article is focused on basic forms and methods to improve the efficiency of innovative activity in the agricultural sector of Ukraine. It was determined that the development of agriculture in Ukraine is affected by a number of factors that must be considered to design innovative models of entrepreneurship development and ways to improve the efficiency of innovative entrepreneurship activity.

  7. Combined-cycle power plant. 500 MW on a single shaft. Active stability improvement of the compressor - methods of analysis. Final report; GuD-Kraftwerk, 500 MW auf einer Welle. Aktive Stabilitaetsverbesserung am Verdichter - Analyseverfahren. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Stoff, H.; Methling, F.O.

    2002-07-01

    Various analysis techniques are tested as possible stall and surge avoidance monitoring systems on high-speed axial compressors. Measurements were taken in a 4-stage transonic compressor with igv in the region of stable operation as well as approaching and crossing the surge line with fully developed rotating stall. The measurements contain the static wall pressure in front of each blade row. Artificial neural networks, Fourier techniques and cepstral analysis are investigated. The different methods are checked on a single sensor signal to reduce the instrumentational effort. Using the cepstral analysis a characteristic parameter is calculated which is valid in all investigated regions of operation of the compressor. This characteristic parameter is based on the blade passing frequency, i.e. in the terms of cepstral analysis it is the intensity of the fundamental component as well as the intensities of all its higher harmonics which are covered by the sensor signal. (orig.)

  8. Spatial heterogeneity analysis of brain activation in fMRI.

    Science.gov (United States)

    Gupta, Lalit; Besseling, René M H; Overvliet, Geke M; Hofman, Paul A M; de Louw, Anton; Vaessen, Maarten J; Aldenkamp, Albert P; Ulman, Shrutin; Jansen, Jacobus F A; Backes, Walter H

    2014-01-01

    In many brain diseases it can be qualitatively observed that spatial patterns in blood oxygenation level dependent (BOLD) activation maps appear more (diffusively) distributed than in healthy controls. However, measures that can quantitatively characterize this spatial distributiveness in individual subjects are lacking. In this study, we propose a number of spatial heterogeneity measures to characterize brain activation maps. The proposed methods focus on different aspects of heterogeneity, including the shape (compactness), complexity in the distribution of activated regions (fractal dimension and co-occurrence matrix), and gappiness between activated regions (lacunarity). To this end, functional MRI derived activation maps of a language and a motor task were obtained in language impaired children with (Rolandic) epilepsy and compared to age-matched healthy controls. Group analysis of the activation maps revealed no significant differences between patients and controls for both tasks. However, for the language task the activation maps in patients appeared more heterogeneous than in controls. Lacunarity was the best measure to discriminate activation patterns of patients from controls (sensitivity 74%, specificity 70%) and illustrates the increased irregularity of gaps between activated regions in patients. The combination of heterogeneity measures and a support vector machine approach yielded further increase in sensitivity and specificity to 78% and 80%, respectively. This illustrates that activation distributions in impaired brains can be complex and more heterogeneous than in normal brains and cannot be captured fully by a single quantity. In conclusion, heterogeneity analysis has potential to robustly characterize the increased distributiveness of brain activation in individual patients.

  9. Spatial heterogeneity analysis of brain activation in fMRI

    Directory of Open Access Journals (Sweden)

    Lalit Gupta

    2014-01-01

    Full Text Available In many brain diseases it can be qualitatively observed that spatial patterns in blood oxygenation level dependent (BOLD activation maps appear more (diffusively distributed than in healthy controls. However, measures that can quantitatively characterize this spatial distributiveness in individual subjects are lacking. In this study, we propose a number of spatial heterogeneity measures to characterize brain activation maps. The proposed methods focus on different aspects of heterogeneity, including the shape (compactness, complexity in the distribution of activated regions (fractal dimension and co-occurrence matrix, and gappiness between activated regions (lacunarity. To this end, functional MRI derived activation maps of a language and a motor task were obtained in language impaired children with (Rolandic epilepsy and compared to age-matched healthy controls. Group analysis of the activation maps revealed no significant differences between patients and controls for both tasks. However, for the language task the activation maps in patients appeared more heterogeneous than in controls. Lacunarity was the best measure to discriminate activation patterns of patients from controls (sensitivity 74%, specificity 70% and illustrates the increased irregularity of gaps between activated regions in patients. The combination of heterogeneity measures and a support vector machine approach yielded further increase in sensitivity and specificity to 78% and 80%, respectively. This illustrates that activation distributions in impaired brains can be complex and more heterogeneous than in normal brains and cannot be captured fully by a single quantity. In conclusion, heterogeneity analysis has potential to robustly characterize the increased distributiveness of brain activation in individual patients.

  10. Prompt gamma-ray activation analysis (PGAA)

    Energy Technology Data Exchange (ETDEWEB)

    Kern, J. [Fribourg Univ. (Switzerland). Inst. de Physique

    1996-11-01

    The paper deals with a brief description of the principles of prompt gamma-ray activation analysis (PGAA), with the detection of gamma-rays, the PGAA project at SINQ and with the expected performances. 8 figs., 3 tabs., 10 refs.

  11. Transforming Teacher Education, An Activity Theory Analysis

    Science.gov (United States)

    McNicholl, Jane; Blake, Allan

    2013-01-01

    This paper explores the work of teacher education in England and Scotland. It seeks to locate this work within conflicting sociocultural views of professional practice and academic work. Drawing on an activity theory framework that integrates the analysis of these seemingly contradictory discourses with a study of teacher educators' practical…

  12. Sampling and analysis methods for geothermal fluids and gases

    Energy Technology Data Exchange (ETDEWEB)

    Watson, J.C.

    1978-07-01

    The sampling procedures for geothermal fluids and gases include: sampling hot springs, fumaroles, etc.; sampling condensed brine and entrained gases; sampling steam-lines; low pressure separator systems; high pressure separator systems; two-phase sampling; downhole samplers; and miscellaneous methods. The recommended analytical methods compiled here cover physical properties, dissolved solids, and dissolved and entrained gases. The sequences of methods listed for each parameter are: wet chemical, gravimetric, colorimetric, electrode, atomic absorption, flame emission, x-ray fluorescence, inductively coupled plasma-atomic emission spectroscopy, ion exchange chromatography, spark source mass spectrometry, neutron activation analysis, and emission spectrometry. Material on correction of brine component concentrations for steam loss during flashing is presented. (MHR)

  13. 酸碱法生产活性氧化锌经济性差异对比分析%Comparative analysis on economical difference of activated zinc oxide production by acid/base methods

    Institute of Scientific and Technical Information of China (English)

    蔡建国

    2013-01-01

    By analyzing the economical efficiency of the differences of four methods of manufacturing activated zinc oxide,which are the acid method of adding soda(Na2CO3),the acid method of adding ammonium hydrogen carbonate (NH4HCO3),the ammonia leaching-ammonia distillation method(evaporating ammonia by heating),and carbonization method(by inletting carbon dioxide),it's found that the alkali methods are superior to the acid methods,and the ammonia leaching-ammonia distillation method is the most cost-effective one.Acid methods have higher consumption costs of leaching reagent and synthesizing agent.Furthermore,the acid methods produce a large amount of wastewater during the manufacture process of activated zinc oxide.Since the treatment cost of wastewater is higher than the revenue of product recovery,their economical efficiency is poor.In conclusion,it is recommended to use the ammonia leaching-ammonia distillation method to manufacture activated zinc oxide,because it is not only economical,but also environmentally friendly.%通过对4种生产活性氧化锌工艺,即酸法的加纯碱(Na2CO3)法和加碳酸氢氨(NH4HCO3)法,氨浸法的加热蒸氨让氨挥发法和通入二氧化碳碳化法的差异部分的经济性进行分析,对比发现碱法总体优于酸法,其中以氨浸蒸氨法经济性最佳.酸法不仅存在浸出剂和合成剂消耗成本高,而且酸法生产活性氧化锌会产生大量的废水,废水处理成本高于回收产品的收入,经济性较差.因此推荐用氨浸蒸氨法生产活性氧化锌,不仅经济而且环保.

  14. Critical Security Methods : New Frameworks for Analysis

    NARCIS (Netherlands)

    Voelkner, Nadine; Huysmans, Jef; Claudia, Aradau; Neal, Andrew

    2015-01-01

    Critical Security Methods offers a new approach to research methods in critical security studies. It argues that methods are not simply tools to bridge the gap between security theory and security practice. Rather, to practise methods critically means engaging in a more free and experimental interpl

  15. Critical Security Methods : New Frameworks for Analysis

    NARCIS (Netherlands)

    Voelkner, Nadine; Huysmans, Jef; Claudia, Aradau; Neal, Andrew

    2015-01-01

    Critical Security Methods offers a new approach to research methods in critical security studies. It argues that methods are not simply tools to bridge the gap between security theory and security practice. Rather, to practise methods critically means engaging in a more free and experimental

  16. Basic methods of linear functional analysis

    CERN Document Server

    Pryce, John D

    2011-01-01

    Introduction to the themes of mathematical analysis, geared toward advanced undergraduate and graduate students. Topics include operators, function spaces, Hilbert spaces, and elementary Fourier analysis. Numerous exercises and worked examples.1973 edition.

  17. Interaction patterns of brain activity across space, time and frequency. Part I: methods

    CERN Document Server

    Pascual-Marqui, Roberto D

    2011-01-01

    We consider exploratory methods for the discovery of cortical functional connectivity. Typically, data for the i-th subject (i=1...NS) is represented as an NVxNT matrix Xi, corresponding to brain activity sampled at NT moments in time from NV cortical voxels. A widely used method of analysis first concatenates all subjects along the temporal dimension, and then performs an independent component analysis (ICA) for estimating the common cortical patterns of functional connectivity. There exist many other interesting variations of this technique, as reviewed in [Calhoun et al. 2009 Neuroimage 45: S163-172]. We present methods for the more general problem of discovering functional connectivity occurring at all possible time lags. For this purpose, brain activity is viewed as a function of space and time, which allows the use of the relatively new techniques of functional data analysis [Ramsay & Silverman 2005: Functional data analysis. New York: Springer]. In essence, our method first vectorizes the data from...

  18. An in vitro method for evaluating vascular endothelial ADPase activity.

    Science.gov (United States)

    Caprino, L; Togna, A R; Stella, C; Togna, G

    1996-06-01

    Some xenobiotics, known to promote the development of thrombotic phenomena, affect vascular endothelium ADPase, a regulatory enzyme that inactivates vaso- and platelet-active adenine nucleotides. This proposed new experimental approach represents an improved method of evaluation of vascular endothelial ADPase activity which is assessed by measuring, at pre-established times, the degradation rate of exogenous ADP incubated with aortic bovine patches. The ADP dosage was performed by using a spectrophotometric enzymatic assay. Statistical analyses showed that the method is capable of highlighting the linearity of the ADPase activity time-course, thus indicating that the slopes of time-degradation curves of ADP are a valid index for this endothelial ectoenzyme activity. Results obtained with ADPase inhibiting or stimulating agent confirm that this in vitro method is an efficient tool for estimating the ability of xenobiotics or drugs to modify the nonthrombogenic properties of vascular endothelium.

  19. Analysis of PCA Method in Image Recognition with MATALAB

    Institute of Scientific and Technical Information of China (English)

    ZHAO Ping

    2014-01-01

    The growing need for effective biometric identification is widely acknowledged. Human face recognition is an important area in the field of biometrics. It has been an active area of research for several decades,but still remains a challenging problem because of the complexity of the human face. The Principal Component Analysis(PCA),or the eigenface method,is a de - facto standard in human face recognition. In this paper,the principle of PCA is introduced and the compressing and rebuilding of the image is accomplished with matlab program.

  20. Advanced Software Methods for Physics Analysis

    Science.gov (United States)

    Lista, L.

    2006-01-01

    Unprecedented data analysis complexity is experienced in modern High Energy Physics experiments. The complexity arises from the growing size of recorded data samples, the large number of data analyses performed by different users in each single experiment, and the level of complexity of each single analysis. For this reason, the requirements on software for data analysis impose a very high level of reliability. We present two concrete examples: the former from BaBar experience with the migration to a new Analysis Model with the definition of a new model for the Event Data Store, the latter about a toolkit for multivariate statistical and parametric Monte Carlo analysis developed using generic programming.

  1. Cytotoxic activity and phytochemical analysis of Arum palaestinum Boiss

    Institute of Scientific and Technical Information of China (English)

    Mai Mohammed Farid; Sameh Reda Hussein; Lamiaa Fawzy Ibrahim; Mohammed Ali El Desouky; Amr Mohammed Elsayed; Ahmad Ali El Oqlah; Mahmoud Mohammed Saker

    2015-01-01

    Objective:To evaluate the in vitro cytotoxic activity of the fractionated extract as well as isolated compounds of Arum palaestinum Boiss. (A. palaestinum) (black calla lily), and to identify the volatile components which may be responsible for the potential antitumor activity. Methods: A. palaestinum was collected from its natural habitats and subjected to phytochemical analysis for separation of pure compounds. In vitro cytotoxic activity was investigated against four human carcinoma cell lines Hep2, HeLa, HepG2 and MCF7 for the fractionated extract and isolated compounds. While, the diethyl ether fraction was subjected to GC–MS analysis as it exhibited the most potent cytotoxic effect to evaluate the active constituents responsible for the cytotoxic activities. Results:Four flavonoid compounds were isolated (luteolin, chrysoeriol, isoorientin, isovitexin) from the diethyl ether and ethyl acetate. The extracts and the pure isolated compounds showed a significant high antiproliferative activity against all investigated cell lines. The GC–MS analysis revealed the separation and identification of 15 compounds representing 95.01%of the extract and belonging to different groups of chemical compounds. Conclusions:The present study is considered to be the first report on the cytotoxic activities carried out on different selected fractions and pure compounds of A. palaestinum to provide evidences for its strong antitumor activities. In addition, chrysoeriol and isovitexin compounds were isolated for the first time from the studied taxa.

  2. Cytotoxic activity and phytochemical analysis of Arum palaestinum Boiss.

    Institute of Scientific and Technical Information of China (English)

    Mai; Mohammed; Farid; Sameh; Reda; Hussein; Lamiaa; Fawzy; Ibrahim; Mohammed; Ali; El; Desouky; Amr; Mohammed; Elsayed; Ahmad; Ali; El; Oqlah; Mahmoud; Mohammed; Saker

    2015-01-01

    Objective: To evaluate the in vitro cytotoxic activity of the fractionated extract as well as isolated compounds of Arum palaestinum Boiss.(A. palaestinum)(black calla lily), and to identify the volatile components which may be responsible for the potential antitumor activity.Methods: A. palaestinum was collected from its natural habitats and subjected to phytochemical analysis for separation of pure compounds. In vitro cytotoxic activity was investigated against four human carcinoma cell lines Hep2, He La, Hep G2 and MCF7 for the fractionated extract and isolated compounds. While, the diethyl ether fraction was subjected to GC–MS analysis as it exhibited the most potent cytotoxic effect to evaluate the active constituents responsible for the cytotoxic activities.Results: Four flavonoid compounds were isolated(luteolin, chrysoeriol, isoorientin,isovitexin) from the diethyl ether and ethyl acetate. The extracts and the pure isolated compounds showed a significant high antiproliferative activity against all investigated cell lines. The GC–MS analysis revealed the separation and identification of 15 compounds representing 95.01% of the extract and belonging to different groups of chemical compounds.Conclusions: The present study is considered to be the first report on the cytotoxic activities carried out on different selected fractions and pure compounds of A. palaestinum to provide evidences for its strong antitumor activities. In addition,chrysoeriol and isovitexin compounds were isolated for the first time from the studied taxa.

  3. An improved quantitative analysis method for plant cortical microtubules.

    Science.gov (United States)

    Lu, Yi; Huang, Chenyang; Wang, Jia; Shang, Peng

    2014-01-01

    The arrangement of plant cortical microtubules can reflect the physiological state of cells. However, little attention has been paid to the image quantitative analysis of plant cortical microtubules so far. In this paper, Bidimensional Empirical Mode Decomposition (BEMD) algorithm was applied in the image preprocessing of the original microtubule image. And then Intrinsic Mode Function 1 (IMF1) image obtained by decomposition was selected to do the texture analysis based on Grey-Level Cooccurrence Matrix (GLCM) algorithm. Meanwhile, in order to further verify its reliability, the proposed texture analysis method was utilized to distinguish different images of Arabidopsis microtubules. The results showed that the effect of BEMD algorithm on edge preserving accompanied with noise reduction was positive, and the geometrical characteristic of the texture was obvious. Four texture parameters extracted by GLCM perfectly reflected the different arrangements between the two images of cortical microtubules. In summary, the results indicate that this method is feasible and effective for the image quantitative analysis of plant cortical microtubules. It not only provides a new quantitative approach for the comprehensive study of the role played by microtubules in cell life activities but also supplies references for other similar studies.

  4. An Improved Quantitative Analysis Method for Plant Cortical Microtubules

    Directory of Open Access Journals (Sweden)

    Yi Lu

    2014-01-01

    Full Text Available The arrangement of plant cortical microtubules can reflect the physiological state of cells. However, little attention has been paid to the image quantitative analysis of plant cortical microtubules so far. In this paper, Bidimensional Empirical Mode Decomposition (BEMD algorithm was applied in the image preprocessing of the original microtubule image. And then Intrinsic Mode Function 1 (IMF1 image obtained by decomposition was selected to do the texture analysis based on Grey-Level Cooccurrence Matrix (GLCM algorithm. Meanwhile, in order to further verify its reliability, the proposed texture analysis method was utilized to distinguish different images of Arabidopsis microtubules. The results showed that the effect of BEMD algorithm on edge preserving accompanied with noise reduction was positive, and the geometrical characteristic of the texture was obvious. Four texture parameters extracted by GLCM perfectly reflected the different arrangements between the two images of cortical microtubules. In summary, the results indicate that this method is feasible and effective for the image quantitative analysis of plant cortical microtubules. It not only provides a new quantitative approach for the comprehensive study of the role played by microtubules in cell life activities but also supplies references for other similar studies.

  5. The SMART CLUSTER METHOD - adaptive earthquake cluster analysis and declustering

    Science.gov (United States)

    Schaefer, Andreas; Daniell, James; Wenzel, Friedemann

    2016-04-01

    Earthquake declustering is an essential part of almost any statistical analysis of spatial and temporal properties of seismic activity with usual applications comprising of probabilistic seismic hazard assessments (PSHAs) and earthquake prediction methods. The nature of earthquake clusters and subsequent declustering of earthquake catalogues plays a crucial role in determining the magnitude-dependent earthquake return period and its respective spatial variation. Various methods have been developed to address this issue from other researchers. These have differing ranges of complexity ranging from rather simple statistical window methods to complex epidemic models. This study introduces the smart cluster method (SCM), a new methodology to identify earthquake clusters, which uses an adaptive point process for spatio-temporal identification. Hereby, an adaptive search algorithm for data point clusters is adopted. It uses the earthquake density in the spatio-temporal neighbourhood of each event to adjust the search properties. The identified clusters are subsequently analysed to determine directional anisotropy, focussing on a strong correlation along the rupture plane and adjusts its search space with respect to directional properties. In the case of rapid subsequent ruptures like the 1992 Landers sequence or the 2010/2011 Darfield-Christchurch events, an adaptive classification procedure is applied to disassemble subsequent ruptures which may have been grouped into an individual cluster using near-field searches, support vector machines and temporal splitting. The steering parameters of the search behaviour are linked to local earthquake properties like magnitude of completeness, earthquake density and Gutenberg-Richter parameters. The method is capable of identifying and classifying earthquake clusters in space and time. It is tested and validated using earthquake data from California and New Zealand. As a result of the cluster identification process, each event in

  6. Solving Generalised Riccati Differential Equations by Homotopy Analysis Method

    Directory of Open Access Journals (Sweden)

    J. Vahidi

    2013-07-01

    Full Text Available In this paper, the quadratic Riccati differential equation is solved by means of an analytic technique, namely the homotopy analysis method (HAM. Comparisons are made between Adomian’s decomposition method (ADM and the exact solution and the homotopy analysis method. The results reveal that the proposed method is very effective and simple.

  7. 21 CFR 163.5 - Methods of analysis.

    Science.gov (United States)

    2010-04-01

    ... CONSUMPTION CACAO PRODUCTS General Provisions § 163.5 Methods of analysis. Shell and cacao fat content in cacao products shall be determined by the following methods of analysis prescribed in “Official Methods..._locations.html. (a) Shell content—12th ed. (1975), methods 13.010-13.014, under the heading “Shell in...

  8. Techniques for Surveying Urban Active Faults by Seismic Methods

    Institute of Scientific and Technical Information of China (English)

    Xu Mingcai; Gao Jinghua; Liu Jianxun; Rong Lixin

    2005-01-01

    Using the seismic method to detect active faults directly below cities is an irreplaceable prospecting technique. The seismic method can precisely determine the fault position. Seismic method itself can hardly determine the geological age of fault. However, by considering in connection with the borehole data and the standard geological cross-section of the surveyed area, the geological age of reflected wave group can be qualitatively (or semi-quantitatively)determined from the seismic depth profile. To determine the upper terminal point of active faults directly below city, it is necessary to use the high-resolution seismic reflection technique.To effectively determine the geometric feature of deep faults, especially to determine the relation between deep and shallow fracture structures, the seismic reflection method is better than the seismic refraction method.

  9. Methods for analysis of fluoroquinolones in biological fluids

    Science.gov (United States)

    Methods for analysis of 10 selected fluoroquinolone antibiotics in biological fluids are reviewed. Approaches for sample preparation, detection methods, limits of detection and quantitation and recovery information are provided for both single analyte and multi-analyte fluoroquinolone methods....

  10. Multiscale statistical analysis of coronal solar activity

    CERN Document Server

    Gamborino, Diana; Martinell, Julio J

    2016-01-01

    Multi-filter images from the solar corona are used to obtain temperature maps which are analyzed using techniques based on proper orthogonal decomposition (POD) in order to extract dynamical and structural information at various scales. Exploring active regions before and after a solar flare and comparing them with quiet regions we show that the multiscale behavior presents distinct statistical properties for each case that can be used to characterize the level of activity in a region. Information about the nature of heat transport is also be extracted from the analysis.

  11. Analysis of two drying methods on the yield and activity of sulfated polysaccharides extracted from Halymenia sp. (Rhodophyceae - doi: 10.4025/actascibiolsci.v34i1.6961

    Directory of Open Access Journals (Sweden)

    Norma Maria Barros Benevides

    2011-11-01

    Full Text Available Sulfated polysaccharides (SPs have attracted growing interest for various biotechnological applications. We evaluated the efficiency of two methods of drying SPs (M I and II extracted from Halymenia sp Rhodophyceae in order to compare the yield, purification and anticoagulant activity. The total SPs (TSPs were first extracted with papain in 100 mM sodium acetate (pH 5.0 containing cysteine and EDTA (5 mM. The TSPs obtained were dried in an oven (M I or lyophilized (M II and then examined by ion exchange chromatography (DEAE-cellulose using the NaCl gradient technique. The fractions were analyzed by 0.5% agarose gel electrophoresis and the in vitro anticoagulant activity was evaluated by the activated partial thromboplastin time test using normal human plasma and compared to heparin (HEP (193.00 IU mg-1. There was a difference in TSP yield of 19.05% and similar chromatographic SP profiles. Electrophoresis revealed fractions with distinct resolutions. The fractions eluted with 0.75 M of salt (M I and II were the most active, measuring 27.40 and 72.66 IU mg-1, respectively, when compared to HEP. Therefore, obtaining SP with anticoagulant activity from Halymenia sp. is more efficient by freeze-drying. 

  12. Application of neutron activation analysis method in leaves of Casearia obliqua medicinal plant; Aplicacao do metodo de analise por ativacao com neutrons na analise de folhas da planta medicinal Casearia obliqua

    Energy Technology Data Exchange (ETDEWEB)

    Yamashita, Celina I.; Saiki, Mitiko [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)]. E-mail: celinayamashita@yahoo.com.br; mitiko@ipen.br; Sertie, Jaime A.A. [Sao Paulo Univ., SP (Brazil). Inst. de Ciencias Biomedicas

    2005-07-01

    The pharmacological properties of medicinal plants have been related to the presence of organic compounds, however elements are also known to have an important participation in the active compounds constitution process. In this study, instrumental neutron activation analysis (INAA) was applied to determine elements in leaves of Casearia obliqua medicinal plant collected at two different locations in the Atlantic Forest, Brazil, SP. Soil samples collected from where this plant was grown were also analyzed in order to verify if there is a correlation between the elements present in soils and plant leaves. Br, Ca, Cl, Co, Cr, Cs, Fe, K, La, Mn, Na, Rb, Sb, Sc and Zn were determined in C. obliqua leaves and the elements As, Ca, Ce, Eu, Fe, Hf, La, Lu, Nd, Rb, Sc, Sm, Tb, Th, U and Zn in soils. Soil samples collected from two different locations presented similar concentrations for most elements. Likewise, C. obliqua leaves collected from the two locations presented similar elemental contents. These results suggest that analysis of extracts from these leaf samples and the evaluation of their pharmacological activities should be carried out. Certified reference materials IAEA-Soil-7, USGS W-1, NIST 1573a Tomato Leaves and NIST 1515 Apple Leaves were analyzed and the quality of the obtained results was assured. (author)

  13. Perspective of regulation on software safety analysis: experience of software safety analysis activity of Lungmen project

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Chuan Chung [Taiwan Power Company, Taipei TW (China)

    2005-11-15

    Software Safety Analysis is one of the essential tasks must be performed in the design work of digital computer software used in safety system of Nuclear Power Station. While there is more experience in Software Verification and Validation and Configuration Management in software industry, Software Safety Analysis (SSA) is a new task. What is the scope of SSA? What should be done in SSA? Various SSA related code and Standards were reviewed and from the evolvement of code and standards, it was concluded that Abnormal Condition and Events should be treated as part of SSA activities and SSA activities could be one of the activities in Software V and V SSA case study on NUMAC as Pervious Developed System was presented and a new method on SSA - 'Hazard Analysis and Defense in Depth for Software Safety Analysis' to enhance the confidence in SSA activities in Lungmen project was introduced.

  14. New analysis method of seismic active earth pressure and its distribution on a retaining wall%地震条件下挡土墙主动土压力及其分布的新分析法

    Institute of Scientific and Technical Information of China (English)

    张国祥

    2014-01-01

    The seismic active earth pressure calculations problem with pseudo-static method is translated into non-seismic active earth pressure calculations problem in this paper using the transform method with rotating calculation model of retaining wall. Depend on the non-seismic active earth pressure formulations with differential layer method, the analytical formulas of resultant force of seismic earth pressure, application position of resultant force and distribution of seismic earth pressure with differential layer method are obtained directly, and the analytical solution of critical rupture angle by graphic method. The influencing factors including horizontal and vertical seismic accelerations, batter angle of wall back,cohesion and external friction angle between filler and back of retaining wall, equispaced overloading can be considered. The formulas can be used for seismic active earth pressure calculations of cohesive soil or non-cohesive soil with common border condition. The rotating seismic angle method in this paper is that the seismic active earth pressure calculation model with pseudo-static method is firstly rotated into static active earth pressure calculation model, and the stress states of retaining wall and soil behind retaining wall are not changed, and then the seismic active earth pressures with pseudo-static method are solved by the calculation methods of static active earth pressures. The deducing process of seismic active earth pressure formulations with pseudo-static method is simplified and unified greatly by using the new method. The seismic active earth pressure theory with pseudo-static method is perfected much more.%采用旋转挡土墙计算模型的变换法,将在地震和拟静力法条件下主动土压力的求解问题转化为在静力条件下主动土压力的求解问题。根据在静力条件下水平层分析法的主动土压力推导结果,直接获得在地震条件下主动土压力强度分布、土压力合力及其

  15. Multiscale Methods for Nuclear Reactor Analysis

    Science.gov (United States)

    Collins, Benjamin S.

    The ability to accurately predict local pin powers in nuclear reactors is necessary to understand the mechanisms that cause fuel pin failure during steady state and transient operation. In the research presented here, methods are developed to improve the local solution using high order methods with boundary conditions from a low order global solution. Several different core configurations were tested to determine the improvement in the local pin powers compared to the standard techniques, that use diffusion theory and pin power reconstruction (PPR). Two different multiscale methods were developed and analyzed; the post-refinement multiscale method and the embedded multiscale method. The post-refinement multiscale methods use the global solution to determine boundary conditions for the local solution. The local solution is solved using either a fixed boundary source or an albedo boundary condition; this solution is "post-refinement" and thus has no impact on the global solution. The embedded multiscale method allows the local solver to change the global solution to provide an improved global and local solution. The post-refinement multiscale method is assessed using three core designs. When the local solution has more energy groups, the fixed source method has some difficulties near the interface: however the albedo method works well for all cases. In order to remedy the issue with boundary condition errors for the fixed source method, a buffer region is used to act as a filter, which decreases the sensitivity of the solution to the boundary condition. Both the albedo and fixed source methods benefit from the use of a buffer region. Unlike the post-refinement method, the embedded multiscale method alters the global solution. The ability to change the global solution allows for refinement in areas where the errors in the few group nodal diffusion are typically large. The embedded method is shown to improve the global solution when it is applied to a MOX/LEU assembly

  16. Methods for Mediation Analysis with Missing Data

    Science.gov (United States)

    Zhang, Zhiyong; Wang, Lijuan

    2013-01-01

    Despite wide applications of both mediation models and missing data techniques, formal discussion of mediation analysis with missing data is still rare. We introduce and compare four approaches to dealing with missing data in mediation analysis including list wise deletion, pairwise deletion, multiple imputation (MI), and a two-stage maximum…

  17. ANALYSIS METHODS OF BANKRUPTCY RISK IN ROMANIAN ENERGY MINING INDUSTRY

    Directory of Open Access Journals (Sweden)

    CORICI MARIAN CATALIN

    2016-12-01

    Full Text Available The study is an analysis of bankruptcy risk and assessing the economic performance of the entity in charge of energy mining industry from southwest region. The scientific activity assesses the risk of bankruptcy using score’s method and some indicators witch reflecting the results obtained and elements from organization balance sheet involved in mining and energy which contributes to the stability of the national energy system. Analysis undertaken is focused on the application of the business organization models that allow a comprehensive assessment of the risk of bankruptcy and be an instrument of its forecast. In this study will be highlighted developments bankruptcy risk within the organization through the Altman model and Conan-Holder model in order to show a versatile image on the organization's ability to ensure business continuity

  18. Research on PGNAA adaptive analysis method with BP neural network

    Science.gov (United States)

    Peng, Ke-Xin; Yang, Jian-Bo; Tuo, Xian-Guo; Du, Hua; Zhang, Rui-Xue

    2016-11-01

    A new approach method to dealing with the puzzle of spectral analysis in prompt gamma neutron activation analysis (PGNAA) is developed and demonstrated. It consists of utilizing BP neural network to PGNAA energy spectrum analysis which is based on Monte Carlo (MC) simulation, the main tasks which we will accomplish as follows: (1) Completing the MC simulation of PGNAA spectrum library, we respectively set mass fractions of element Si, Ca, Fe from 0.00 to 0.45 with a step of 0.05 and each sample is simulated using MCNP. (2) Establishing the BP model of adaptive quantitative analysis of PGNAA energy spectrum, we calculate peak areas of eight characteristic gamma rays that respectively correspond to eight elements in each individual of 1000 samples and that of the standard sample. (3) Verifying the viability of quantitative analysis of the adaptive algorithm where 68 samples were used successively. Results show that the precision when using neural network to calculate the content of each element is significantly higher than the MCLLS.

  19. Analysis of the Peak Resistance Frequency Method.

    Science.gov (United States)

    Wang, Boshuo; Weiland, James D

    2016-10-01

    This study analyzes the peak resistance frequency (PRF) method described by Mercanzini et al., a method that can easily extract the tissue resistance from impedance spectroscopy for many neural engineering applications but has no analytical description thus far. Mathematical analyses and computer simulations were used to explore underlying principles, accuracy, and limitations of the PRF method. The mathematical analyses demonstrated that the PRF method has an inherent but correctable deviation dependent on the idealness of the electrode-tissue interface, which is validated by simulations. Further simulations show that both frequency sampling and noise affect the accuracy of the PRF method, and in general, it performs less accurately than least squares methods. However, the PRF method achieves simplicity and reduced measurement and computation time at the expense of accuracy. From the qualitative results, the PRF method can work with reasonable precision and simplicity, although its limitation and the idealness of the electrode-tissue interface involved should be taken into consideration. This paper provides a mathematical foundation for the PRF method and its practical implementation.

  20. Numerical analysis in electromagnetics the TLM method

    CERN Document Server

    Saguet, Pierre

    2013-01-01

    The aim of this book is to give a broad overview of the TLM (Transmission Line Matrix) method, which is one of the "time-domain numerical methods". These methods are reputed for their significant reliance on computer resources. However, they have the advantage of being highly general.The TLM method has acquired a reputation for being a powerful and effective tool by numerous teams and still benefits today from significant theoretical developments. In particular, in recent years, its ability to simulate various situations with excellent precision, including complex materials, has been

  1. Chemical Analysis Methods for Silicon Carbide

    Institute of Scientific and Technical Information of China (English)

    Shen Keyin

    2006-01-01

    @@ 1 General and Scope This Standard specifies the determination method of silicon dioxide, free silicon, free carbon, total carbon, silicon carbide, ferric sesquioxide in silicon carbide abrasive material.

  2. Research progress of pharmacological activities and analytical methods for plant origin proteins.

    Science.gov (United States)

    Li, Chun-hong; Chen, Cen; Xia, Zhi-ning; Yang, Feng-qing

    2015-07-01

    As one of the important active components of traditional Chinese medicine (TCM), plant origin active proteins have many significant pharmacological functions. According to researches on the plant origin active proteins reported in recent years, pharmacological effects include anti-tumor, immune regulation, anti-oxidant, anti-pathogeny microorganism, anti-thrombus, as well as hypolipidemic and hypoglycemic activities of plant origin were reviewed, respectively. On the other hand, the analytical methods including chromatography, spectroscopy, electrophoresis and mass spectrometry for plant origin proteins analysis were also summarized. The main purpose of this paper is providing a reference for future development and application of plant active proteins.

  3. Reliability Analysis of Slope Stability by Central Point Method

    OpenAIRE

    Li, Chunge; WU Congliang

    2015-01-01

    Given uncertainty and variability of the slope stability analysis parameter, the paper proceed from the perspective of probability theory and statistics based on the reliability theory. Through the central point method of reliability analysis, performance function about the reliability of slope stability analysis is established. What’s more, the central point method and conventional limit equilibrium methods do comparative analysis by calculation example. The approach’s numerical ...

  4. A generalized method of active RC network synthesis.

    Science.gov (United States)

    Leach, D. P.; Chan, S.-P.

    1971-01-01

    A completely general active RC network synthesis technique using a grounded gyrator and a summing amplifier is described. The technique overcomes serious limitations of previous RC-gyrator realizations and offers advantages o ver other general active RC synthesis methods. The technique is well suited for construction using thin-film RC networks and integrated circuit operational amplifiers, and provides a configuration which is quite insensitive to element variations.

  5. Computational Models for Analysis of Illicit Activities

    DEFF Research Database (Denmark)

    Nizamani, Sarwat

    Numerous illicit activities happen in our society, which, from time to time affect the population by harming individuals directly or indirectly. Researchers from different disciplines have contributed to developing strategies to analyze such activities, in order to help law enforcement agents....... These models include a model for analyzing evolution of terrorist networks; a text classification model for detecting suspicious text and identification of suspected authors of anonymous emails; and a semantic analysis model for news reports, which may help analyze the illicit activities in certain area...... with location and temporal information. For the network evolution, the hierarchical agglomerative clustering approach has been applied to terrorist networks as case studies. The networks' evolutions show that how individual actors who are initially isolated from each other are converted in small groups, which...

  6. Ensemble Methods for Classification of Physical Activities from Wrist Accelerometry.

    Science.gov (United States)

    Chowdhury, Alok Kumar; Tjondronegoro, Dian; Chandran, Vinod; Trost, Stewart G

    2017-09-01

    To investigate whether the use of ensemble learning algorithms improve physical activity recognition accuracy compared to the single classifier algorithms, and to compare the classification accuracy achieved by three conventional ensemble machine learning methods (bagging, boosting, random forest) and a custom ensemble model comprising four algorithms commonly used for activity recognition (binary decision tree, k nearest neighbor, support vector machine, and neural network). The study used three independent data sets that included wrist-worn accelerometer data. For each data set, a four-step classification framework consisting of data preprocessing, feature extraction, normalization and feature selection, and classifier training and testing was implemented. For the custom ensemble, decisions from the single classifiers were aggregated using three decision fusion methods: weighted majority vote, naïve Bayes combination, and behavior knowledge space combination. Classifiers were cross-validated using leave-one subject out cross-validation and compared on the basis of average F1 scores. In all three data sets, ensemble learning methods consistently outperformed the individual classifiers. Among the conventional ensemble methods, random forest models provided consistently high activity recognition; however, the custom ensemble model using weighted majority voting demonstrated the highest classification accuracy in two of the three data sets. Combining multiple individual classifiers using conventional or custom ensemble learning methods can improve activity recognition accuracy from wrist-worn accelerometer data.

  7. Steel mill products analysis using qualities methods

    Directory of Open Access Journals (Sweden)

    B. Gajdzik

    2016-10-01

    Full Text Available The article presents the subject matter of steel mill product analysis using quality tools. The subject of quality control were bolts and a ball bushing. The Pareto chart and fault mode and effect analysis (FMEA were used to assess faultiness of the products. The faultiness analysis in case of the bolt enabled us to detect the following defects: failure to keep the dimensional tolerance, dents and imprints, improper roughness, lack of pre-machining, non-compatibility of the electroplating and faults on the surface. Analysis of the ball bushing has also revealed defects such as: failure to keep the dimensional tolerance, dents and imprints, improper surface roughness, lack of surface premachining as well as sharp edges and splitting of the material.

  8. Progress in spatial analysis methods and applications

    CERN Document Server

    Páez, Antonio; Buliung, Ron N; Dall'erba, Sandy

    2010-01-01

    This book brings together developments in spatial analysis techniques, including spatial statistics, econometrics, and spatial visualization, and applications to fields such as regional studies, transportation and land use, population and health.

  9. Computational methods for corpus annotation and analysis

    CERN Document Server

    Lu, Xiaofei

    2014-01-01

    This book reviews computational tools for lexical, syntactic, semantic, pragmatic and discourse analysis, with instructions on how to obtain, install and use each tool. Covers studies using Natural Language Processing, and offers ideas for better integration.

  10. Analysis of queues methods and applications

    CERN Document Server

    Gautam, Natarajan

    2012-01-01

    Introduction Analysis of Queues: Where, What, and How?Systems Analysis: Key ResultsQueueing Fundamentals and Notations Psychology in Queueing Reference Notes Exercises Exponential Interarrival and Service Times: Closed-Form Expressions Solving Balance Equations via Arc CutsSolving Balance Equations Using Generating Functions Solving Balance Equations Using Reversibility Reference Notes ExercisesExponential Interarrival and Service Times: Numerical Techniques and Approximations Multidimensional Birth and Death ChainsMultidimensional Markov Chains Finite-State Markov ChainsReference Notes Exerci

  11. Optimizing human activity patterns using global sensitivity analysis.

    Science.gov (United States)

    Fairchild, Geoffrey; Hickmann, Kyle S; Mniszewski, Susan M; Del Valle, Sara Y; Hyman, James M

    2014-12-01

    Implementing realistic activity patterns for a population is crucial for modeling, for example, disease spread, supply and demand, and disaster response. Using the dynamic activity simulation engine, DASim, we generate schedules for a population that capture regular (e.g., working, eating, and sleeping) and irregular activities (e.g., shopping or going to the doctor). We use the sample entropy (SampEn) statistic to quantify a schedule's regularity for a population. We show how to tune an activity's regularity by adjusting SampEn, thereby making it possible to realistically design activities when creating a schedule. The tuning process sets up a computationally intractable high-dimensional optimization problem. To reduce the computational demand, we use Bayesian Gaussian process regression to compute global sensitivity indices and identify the parameters that have the greatest effect on the variance of SampEn. We use the harmony search (HS) global optimization algorithm to locate global optima. Our results show that HS combined with global sensitivity analysis can efficiently tune the SampEn statistic with few search iterations. We demonstrate how global sensitivity analysis can guide statistical emulation and global optimization algorithms to efficiently tune activities and generate realistic activity patterns. Though our tuning methods are applied to dynamic activity schedule generation, they are general and represent a significant step in the direction of automated tuning and optimization of high-dimensional computer simulations.

  12. The simulation study of three typical time frequency analysis methods

    Directory of Open Access Journals (Sweden)

    Li Yifeng

    2017-01-01

    Full Text Available The principals and characteristics of three typical time frequency analysis methods that Short Time Furious transformation, wavelet transformation and Hilbert-Huang transformation are introduced, and the mathematical definition, characteristics and application ranges of these analysis methods and so on are pointed out, then their time-frequency local performance is made analysis and comparison through computer programming and simulation.

  13. Applying Activity Based Costing (ABC Method to Calculate Cost Price in Hospital and Remedy Services

    Directory of Open Access Journals (Sweden)

    A Dabiri

    2012-04-01

    Full Text Available Background: Activity Based Costing (ABC is one of the new methods began appearing as a costing methodology in the 1990. It calculates cost price by determining the usage of resources. In this study, ABC method was used for calculating cost price of remedial services in hospitals.Methods: To apply ABC method, Shahid Faghihi Hospital was selected. First, hospital units were divided into three main departments: administrative, diagnostic, and hospitalized. Second, activity centers were defined by the activity analysis method. Third, costs of administrative activity centers were allocated into diagnostic and operational departments based on the cost driver. Finally, with regard to the usage of cost objectives from services of activity centers, the cost price of medical services was calculated.Results: The cost price from ABC method significantly differs from tariff method. In addition, high amount of indirect costs in the hospital indicates that capacities of resources are not used properly.Conclusion: Cost price of remedial services with tariff method is not properly calculated when compared with ABC method. ABC calculates cost price by applying suitable mechanisms but tariff method is based on the fixed price. In addition, ABC represents useful information about the amount and combination of cost price services.

  14. Methods of Fourier analysis and approximation theory

    CERN Document Server

    Tikhonov, Sergey

    2016-01-01

    Different facets of interplay between harmonic analysis and approximation theory are covered in this volume. The topics included are Fourier analysis, function spaces, optimization theory, partial differential equations, and their links to modern developments in the approximation theory. The articles of this collection were originated from two events. The first event took place during the 9th ISAAC Congress in Krakow, Poland, 5th-9th August 2013, at the section “Approximation Theory and Fourier Analysis”. The second event was the conference on Fourier Analysis and Approximation Theory in the Centre de Recerca Matemàtica (CRM), Barcelona, during 4th-8th November 2013, organized by the editors of this volume. All articles selected to be part of this collection were carefully reviewed.

  15. Inference of splicing regulatory activities by sequence neighborhood analysis.

    Directory of Open Access Journals (Sweden)

    Michael B Stadler

    2006-11-01

    Full Text Available Sequence-specific recognition of nucleic-acid motifs is critical to many cellular processes. We have developed a new and general method called Neighborhood Inference (NI that predicts sequences with activity in regulating a biochemical process based on the local density of known sites in sequence space. Applied to the problem of RNA splicing regulation, NI was used to predict hundreds of new exonic splicing enhancer (ESE and silencer (ESS hexanucleotides from known human ESEs and ESSs. These predictions were supported by cross-validation analysis, by analysis of published splicing regulatory activity data, by sequence-conservation analysis, and by measurement of the splicing regulatory activity of 24 novel predicted ESEs, ESSs, and neutral sequences using an in vivo splicing reporter assay. These results demonstrate the ability of NI to accurately predict splicing regulatory activity and show that the scope of exonic splicing regulatory elements is substantially larger than previously anticipated. Analysis of orthologous exons in four mammals showed that the NI score of ESEs, a measure of function, is much more highly conserved above background than ESE primary sequence. This observation indicates a high degree of selection for ESE activity in mammalian exons, with surprisingly frequent interchangeability between ESE sequences.

  16. A fast and efficient method for device level layout analysis

    Science.gov (United States)

    Dong, YaoQi; Zou, Elaine; Pang, Jenny; Huang, Lucas; Yang, Legender; Zhang, Chunlei; Du, Chunshan; Hu, Xinyi; Wan, Qijian

    2017-03-01

    There is an increasing demand for device level layout analysis, especially as technology advances. The analysis is to study standard cells by extracting and classifying critical dimension parameters. There are couples of parameters to extract, like channel width, length, gate to active distance, and active to adjacent active distance, etc. for 14nm technology, there are some other parameters that are cared about. On the one hand, these parameters are very important for studying standard cell structures and spice model development with the goal of improving standard cell manufacturing yield and optimizing circuit performance; on the other hand, a full chip device statistics analysis can provide useful information to diagnose the yield issue. Device analysis is essential for standard cell customization and enhancements and manufacturability failure diagnosis. Traditional parasitic parameters extraction tool like Calibre xRC is powerful but it is not sufficient for this device level layout analysis application as engineers would like to review, classify and filter out the data more easily. This paper presents a fast and efficient method based on Calibre equation-based DRC (eqDRC). Equation-based DRC extends the traditional DRC technology to provide a flexible programmable modeling engine which allows the end user to define grouped multi-dimensional feature measurements using flexible mathematical expressions. This paper demonstrates how such an engine and its programming language can be used to implement critical device parameter extraction. The device parameters are extracted and stored in a DFM database which can be processed by Calibre YieldServer. YieldServer is data processing software that lets engineers query, manipulate, modify, and create data in a DFM database. These parameters, known as properties in eqDRC language, can be annotated back to the layout for easily review. Calibre DesignRev can create a HTML formatted report of the results displayed in Calibre

  17. Game data analysis tools and methods

    CERN Document Server

    Coupart, Thibault

    2013-01-01

    This book features an introduction to the basic theoretical tenets of data analysis from a game developer's point of view, as well as a practical guide to performing gameplay analysis on a real-world game.This book is ideal for video game developers who want to try and experiment with the game analytics approach for their own productions. It will provide a good overview of the themes you need to pay attention to, and will pave the way for success. Furthermore, the book also provides a wide range of concrete examples that will be useful for any game data analysts or scientists who want to impro

  18. SAGE Research Methods Datasets: A Data Analysis Educational Tool.

    Science.gov (United States)

    Vardell, Emily

    2016-01-01

    SAGE Research Methods Datasets (SRMD) is an educational tool designed to offer users the opportunity to obtain hands-on experience with data analysis. Users can search for and browse authentic datasets by method, discipline, and data type. Each of the datasets are supplemented with educational material on the research method and clear guidelines for how to approach data analysis.

  19. Antioxidant activity of wine assessed by different in vitro methods

    Directory of Open Access Journals (Sweden)

    Di Lorenzo Chiara

    2017-01-01

    Full Text Available Epidemiological studies have suggested that a diet rich in antioxidant compounds could help in counteracting the effects of reactive oxygen species, reducing the risk factors for chronic diseases. The moderate consumption of wine, especially red wine, has been associated with the reduction in mortalities from cardiovascular diseases. One of the possible reasons for the protective effect of wine can be identified in the high content of polyphenols (mainly flavonoids, which have significant antioxidant activity. Even though several in vitro tests have been developed for the measure of the antioxidant property, no method has showed a satisfactory correlation with the in vivo situation. On these bases, the aim of this study was the application and comparison of different in vitro methods to assess the antioxidant activity of red, rosé and white wines. The methods were: 1 Folin-Cocalteau's assay for the quantification of total polyphenol content; 2 the DPPH (1,1-diphenyl-2-picrylhydrazyl spectrophotometric assay and the Trolox Equivalent Antioxidant Capacity (TEAC spectrophotometric assay for measuring the antioxidant activity of samples; 3 High Performance Thin Layer Chromatography for separation of phenolic substances and assessment of the associated antioxidant activity; 4 electrochemical detection by using a biosensor. Although all the approaches show some limitations, this battery of tests offers a more reliable body of data on the antioxidant activity of vine derivatives.

  20. An Experimental Method for the Active Learning of Greedy Algorithms

    Science.gov (United States)

    Velazquez-Iturbide, J. Angel

    2013-01-01

    Greedy algorithms constitute an apparently simple algorithm design technique, but its learning goals are not simple to achieve.We present a didacticmethod aimed at promoting active learning of greedy algorithms. The method is focused on the concept of selection function, and is based on explicit learning goals. It mainly consists of an…

  1. A method to determine validity and reliability of activity sensors

    NARCIS (Netherlands)

    Boerema, S.T.; Hermens, H.J.

    2013-01-01

    METHOD Four sensors were securely fastened to a mechanical oscillator (Vibration Exciter, type 4809, Brüel & Kjær) and moved at various frequencies (6.67Hz; 13.45Hz; 19.88Hz) within the range of human physical activity. For each of the three sensor axes, the sensors were simultaneously moved for fiv

  2. Low-Threshold Active Teaching Methods for Mathematic Instruction

    Science.gov (United States)

    Marotta, Sebastian M.; Hargis, Jace

    2011-01-01

    In this article, we present a large list of low-threshold active teaching methods categorized so the instructor can efficiently access and target the deployment of conceptually based lessons. The categories include teaching strategies for lecture on large and small class sizes; student action individually, in pairs, and groups; games; interaction…

  3. A novel electrochemical method to determine α-amylase activity.

    Science.gov (United States)

    Zhang, Juan; Cui, Junhui; Liu, Ying; Chen, Yangyang; Li, Genxi

    2014-07-07

    In this paper, we report a novel electrochemical method that can be developed as a biosensor for simple and direct determination of α-amylase activity. The method is based on the hydrolysis of maltopentaose, the substrate of the enzyme, which is immobilized on the surface of a gold electrode, and the induced charge changes of the substrate-modified electrode. Specifically, the substrate maltopentaose is immobilized onto a gold electrode surface via a simple and direct immobilization technique that involves a one-step and site-specific attachment of unmodified maltopentaose to the hydrazide-derivatized surface. So, by analyzing the electrochemical signal obtained from the electro-active molecule [Ru(NH3)5Cl](2+) during the hydrolysis of maltopentaose, the determination of α-amylase activity is achieved. Under optimized conditions, α-amylase activity can be assayed with a detection limit of 0.022 U mL(-1). The biosensor exhibits a rapid response, good stability and anti-interference ability. Furthermore, the biosensor has also been successfully applied to detect α-amylase in human serum, which shows acceptable accuracy compared to the currently used clinical method. The proposed method in this work may also have potential application of α-amylase determination in real blood samples, diagnostics and food production in the future.

  4. Active Subspace Methods for Data-Intensive Inverse Problems

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Qiqi [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

    2017-04-27

    The project has developed theory and computational tools to exploit active subspaces to reduce the dimension in statistical calibration problems. This dimension reduction enables MCMC methods to calibrate otherwise intractable models. The same theoretical and computational tools can also reduce the measurement dimension for calibration problems that use large stores of data.

  5. An Experimental Method for the Active Learning of Greedy Algorithms

    Science.gov (United States)

    Velazquez-Iturbide, J. Angel

    2013-01-01

    Greedy algorithms constitute an apparently simple algorithm design technique, but its learning goals are not simple to achieve.We present a didacticmethod aimed at promoting active learning of greedy algorithms. The method is focused on the concept of selection function, and is based on explicit learning goals. It mainly consists of an…

  6. Root selection methods in flood analysis

    Directory of Open Access Journals (Sweden)

    B. Parmentier

    2003-01-01

    Full Text Available In the 1970s, de Laine developed a root-matching procedure for estimating unit hydrograph ordinates from estimates of the fast component of the total runoff from multiple storms. Later, Turner produced a root selection method which required only data from one storm event and was based on recognising a pattern typical of unit hydrograph roots. Both methods required direct runoff data, i.e. prior separation of the slow response. This paper introduces a further refinement, called root separation, which allows the estimation of both the unit hydrograph ordinates and the effective precipitation from the full discharge hydrograph. It is based on recognising and separating the quicker component of the response from the much slower components due to interflow and/or baseflow. The method analyses the z-transform roots of carefully selected segments of the full hydrograph. The root patterns of these separate segments tend to be dominated by either the fast response or the slow response. This paper shows how their respective time-scales can be distinguished with an accuracy sufficient for practical purposes. As an illustration, theoretical equations are derived for a conceptual rainfall-runoff system with the input split between fast and slow reservoirs in parallel. These are solved analytically to identify the reservoir constants and the input splitting parameter. The proposed method, called 'root separation', avoids the subjective selection of rainfall roots in the Turner method as well as the subjective matching of roots in the original de Laine method. Keywords: unit hydrograph,identification methods, z-transform, polynomial roots, root separation, fast andslow response, Nash cascade

  7. On two methods of statistical image analysis

    NARCIS (Netherlands)

    Missimer, J; Knorr, U; Maguire, RP; Herzog, H; Seitz, RJ; Tellman, L; Leenders, KL

    1999-01-01

    The computerized brain atlas (CBA) and statistical parametric mapping (SPM) are two procedures for voxel-based statistical evaluation of PET activation studies. Each includes spatial standardization of image volumes, computation of a statistic, and evaluation of its significance. In addition, smooth

  8. Analysis of Two Methods to Evaluate Antioxidants

    Science.gov (United States)

    Tomasina, Florencia; Carabio, Claudio; Celano, Laura; Thomson, Leonor

    2012-01-01

    This exercise is intended to introduce undergraduate biochemistry students to the analysis of antioxidants as a biotechnological tool. In addition, some statistical resources will also be used and discussed. Antioxidants play an important metabolic role, preventing oxidative stress-mediated cell and tissue injury. Knowing the antioxidant content…

  9. Statistical Smoothing Methods and Image Analysis

    Science.gov (United States)

    1988-12-01

    83 - 111. Rosenfeld, A. and Kak, A.C. (1982). Digital Picture Processing. Academic Press,Qrlando. Serra, J. (1982). Image Analysis and Mat hematical ...hypothesis testing. IEEE Trans. Med. Imaging, MI-6, 313-319. Wicksell, S.D. (1925) The corpuscle problem. A mathematical study of a biometric problem

  10. An ESDIRK Method with Sensitivity Analysis Capabilities

    DEFF Research Database (Denmark)

    Kristensen, Morten Rode; Jørgensen, John Bagterp; Thomsen, Per Grove

    2004-01-01

    A new algorithm for numerical sensitivity analysis of ordinary differential equations (ODEs) is presented. The underlying ODE solver belongs to the Runge-Kutta family. The algorithm calculates sensitivities with respect to problem parameters and initial conditions, exploiting the special structure...

  11. Analysis Methods Of The Insolvency Risk

    Directory of Open Access Journals (Sweden)

    Gabriela Munteanu

    2010-12-01

    Full Text Available A company’s capacity to be solvent/able* – to defeat the insolvencyrisk, has an important position within the System of financial-patrimonial analysis. Any problem regarding the payment of obligatory taxes generates prejudice and requires urgent solving.

  12. Mixed Methods Analysis of Enterprise Social Networks

    DEFF Research Database (Denmark)

    Behrendt, Sebastian; Richter, Alexander; Trier, Matthias

    2014-01-01

    The increasing use of enterprise social networks (ESN) generates vast amounts of data, giving researchers and managerial decision makers unprecedented opportunities for analysis. However, more transparency about the available data dimensions and how these can be combined is needed to yield accurate...

  13. Analysis of Two Methods to Evaluate Antioxidants

    Science.gov (United States)

    Tomasina, Florencia; Carabio, Claudio; Celano, Laura; Thomson, Leonor

    2012-01-01

    This exercise is intended to introduce undergraduate biochemistry students to the analysis of antioxidants as a biotechnological tool. In addition, some statistical resources will also be used and discussed. Antioxidants play an important metabolic role, preventing oxidative stress-mediated cell and tissue injury. Knowing the antioxidant content…

  14. 作业成本法在高速公路施工项目中的应用分析%Analysis of Applying the Activity-based Costing Method in Expressway Construction Project

    Institute of Scientific and Technical Information of China (English)

    高萍

    2012-01-01

    Cost management is an important part of expressway construction project management.The article analyzed the existing problems in the cost management of expressway construction projects, proposed the concept of applying the activity-based costing method in expressway construction projects, and analyzed the favorable and unfavorable factors of applying the activity-based costing method in expressway construction projects.%成本管理是高速公路工程施工项目管理中的重要组成部分。文章分析了高速公路施工项目成本管理所存在的问题,提出了作业成本法应用于高速公路施工项目的理念,并分析了作业成本法在高速公路施工项目中应用的有利因素与不利因素。

  15. Adaptive Current Control Method for Hybrid Active Power Filter

    Science.gov (United States)

    Chau, Minh Thuyen

    2016-09-01

    This paper proposes an adaptive current control method for Hybrid Active Power Filter (HAPF). It consists of a fuzzy-neural controller, identification and prediction model and cost function. The fuzzy-neural controller parameters are adjusted according to the cost function minimum criteria. For this reason, the proposed control method has a capability on-line control clings to variation of the load harmonic currents. Compared to the single fuzzy logic control method, the proposed control method shows the advantages of better dynamic response, compensation error in steady-state is smaller, able to online control is better and harmonics cancelling is more effective. Simulation and experimental results have demonstrated the effectiveness of the proposed control method.

  16. Comparative analysis of multiple target tracking methods

    Directory of Open Access Journals (Sweden)

    Michael Kamaraj Devadoss

    2016-07-01

    Full Text Available Many applications such as intelligent transportation, video surveillance, robotics of computer vision mainly depend on task of multiple object tracking. It includes the process of detection, classifications and tracking. The main focus of the study is to develop an efficient and effective multiple target tracking methods to solve the issues of illumination changes, occlusions and affinity matching. Accordingly, the various multiple target tracking methods are tested and evaluated using the metrics on publicly available datasets from which it is obvious that the outcome of the global energy minimization and optimization techniques is comparatively better than any other existing techniques in all aspects. This comparative study work will also help in better understanding of the problem, knowledge of the methods and experimental evaluation skill for further research works.

  17. Cluster analysis of activity-time series in motor learning

    DEFF Research Database (Denmark)

    Balslev, Daniela; Nielsen, Finn Årup; Frutiger, Sally A.

    2002-01-01

    Neuroimaging studies of learning focus on brain areas where the activity changes as a function of time. To circumvent the difficult problem of model selection, we used a data-driven analytic tool, cluster analysis, which extracts representative temporal and spatial patterns from the voxel......-time series. The optimal number of clusters was chosen using a cross-validated likelihood method, which highlights the clustering pattern that generalizes best over the subjects. Data were acquired with PET at different time points during practice of a visuomotor task. The results from cluster analysis show...... practice-related activity in a fronto-parieto-cerebellar network, in agreement with previous studies of motor learning. These voxels were separated from a group of voxels showing an unspecific time-effect and another group of voxels, whose activation was an artifact from smoothing. Hum. Brain Mapping 15...

  18. Cluster analysis of activity-time series in motor learning

    DEFF Research Database (Denmark)

    Balslev, Daniela; Nielsen, Finn Å; Futiger, Sally A

    2002-01-01

    Neuroimaging studies of learning focus on brain areas where the activity changes as a function of time. To circumvent the difficult problem of model selection, we used a data-driven analytic tool, cluster analysis, which extracts representative temporal and spatial patterns from the voxel......-time series. The optimal number of clusters was chosen using a cross-validated likelihood method, which highlights the clustering pattern that generalizes best over the subjects. Data were acquired with PET at different time points during practice of a visuomotor task. The results from cluster analysis show...... practice-related activity in a fronto-parieto-cerebellar network, in agreement with previous studies of motor learning. These voxels were separated from a group of voxels showing an unspecific time-effect and another group of voxels, whose activation was an artifact from smoothing...

  19. Cluster analysis of activity-time series in motor learning

    DEFF Research Database (Denmark)

    Balslev, Daniela; Nielsen, Finn Å; Futiger, Sally A

    2002-01-01

    Neuroimaging studies of learning focus on brain areas where the activity changes as a function of time. To circumvent the difficult problem of model selection, we used a data-driven analytic tool, cluster analysis, which extracts representative temporal and spatial patterns from the voxel......-time series. The optimal number of clusters was chosen using a cross-validated likelihood method, which highlights the clustering pattern that generalizes best over the subjects. Data were acquired with PET at different time points during practice of a visuomotor task. The results from cluster analysis show...... practice-related activity in a fronto-parieto-cerebellar network, in agreement with previous studies of motor learning. These voxels were separated from a group of voxels showing an unspecific time-effect and another group of voxels, whose activation was an artifact from smoothing...

  20. SIMS: a hybrid method for rapid conformational analysis.

    Directory of Open Access Journals (Sweden)

    Bryant Gipson

    Full Text Available Proteins are at the root of many biological functions, often performing complex tasks as the result of large changes in their structure. Describing the exact details of these conformational changes, however, remains a central challenge for computational biology due the enormous computational requirements of the problem. This has engendered the development of a rich variety of useful methods designed to answer specific questions at different levels of spatial, temporal, and energetic resolution. These methods fall largely into two classes: physically accurate, but computationally demanding methods and fast, approximate methods. We introduce here a new hybrid modeling tool, the Structured Intuitive Move Selector (sims, designed to bridge the divide between these two classes, while allowing the benefits of both to be seamlessly integrated into a single framework. This is achieved by applying a modern motion planning algorithm, borrowed from the field of robotics, in tandem with a well-established protein modeling library. sims can combine precise energy calculations with approximate or specialized conformational sampling routines to produce rapid, yet accurate, analysis of the large-scale conformational variability of protein systems. Several key advancements are shown, including the abstract use of generically defined moves (conformational sampling methods and an expansive probabilistic conformational exploration. We present three example problems that sims is applied to and demonstrate a rapid solution for each. These include the automatic determination of "active" residues for the hinge-based system Cyanovirin-N, exploring conformational changes involving long-range coordinated motion between non-sequential residues in Ribose-Binding Protein, and the rapid discovery of a transient conformational state of Maltose-Binding Protein, previously only determined by Molecular Dynamics. For all cases we provide energetic validations using well

  1. A general method for determining secondary active transporter substrate stoichiometry.

    Science.gov (United States)

    Fitzgerald, Gabriel A; Mulligan, Christopher; Mindell, Joseph A

    2017-01-25

    The number of ions required to drive substrate transport through a secondary active transporter determines the protein's ability to create a substrate gradient, a feature essential to its physiological function, and places fundamental constraints on the transporter's mechanism. Stoichiometry is known for a wide array of mammalian transporters, but, due to a lack of readily available tools, not for most of the prokaryotic transporters for which high-resolution structures are available. Here, we describe a general method for using radiolabeled substrate flux assays to determine coupling stoichiometries of electrogenic secondary active transporters reconstituted in proteoliposomes by measuring transporter equilibrium potentials. We demonstrate the utility of this method by determining the coupling stoichiometry of VcINDY, a bacterial Na(+)-coupled succinate transporter, and further validate it by confirming the coupling stoichiometry of vSGLT, a bacterial sugar transporter. This robust thermodynamic method should be especially useful in probing the mechanisms of transporters with available structures.

  2. [Ureasic activity in soy products. Proposal of a new method].

    Science.gov (United States)

    Olguin, M C; Zingale, M I; Revelant, G C; Vignale, M E

    2001-09-01

    The evaluation of residual ureasic activity in soy products is usually employed as an indicator of the efficiency of the inhibition treatments. The purpose of this study is to compare the AACC method (22-90), based on differences of pH, with an assay where ureasic activity is measured by its hydrolytic action on urea and quantification of the ammonium produced with Berthelot reaction. Twenty different samples of soy bean flour with and without thermal inactivation treatments were assessed with the two methods. The new method has a good correlation with that of the AACC--r = 0.9416 (p < 0.0001). It also presents a better specificity because it measures the concentration of the reaction product and shows a more amplified answer than the increase of pH.

  3. Development of HANARO Activation Analysis System and Utilization Technology

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Y. S.; Moon, J. H.; Cho, H. J. (and others)

    2007-06-15

    1. Establishment of evaluation system using a data for a neutron activation analysis : Improvement of NAA measurement system and its identification, Development of combined data evaluation code of NAA/PGAA, International technical cooperation project 2. Development of technique for a industrial application of high precision gamma nuclide spectroscopic analysis : Analytical quality control, Development of industrial application techniques and its identification 3. Industrial application research for a prompt gamma-ray activation analysis : Improvement of Compton suppression counting system (PGAA), Development of applied technology using a PGAA system 4. Establishment of NAA user supporting system and KOLAS management : Development and validation of KOLAS/ISO accreditation testing and identification method, Cooperation researches for a industrial application, Establishment of integrated user analytical supporting system, Accomplishment of sample irradiation facility.

  4. Soybean phospholipase D activity determination. A comparison of two methods

    Directory of Open Access Journals (Sweden)

    Ré, E.

    2007-09-01

    Full Text Available Due to a discrepancy between previously published results, two methods to determine the soybean phospholipase D activity were evaluated. One method is based on the extraction of the enzyme from whole soybean flour, quantifying the enzyme activity on the extract. The other method quantifies the enzymatic activity on whole soybean flour without enzyme extraction. In the extraction-based-method, both the extraction time and the number of extractions were optimized. The highest phospholipase D activity values were obtained from the method without enzyme extraction. This method is less complex, requires less running-time and the conditions of the medium in which phospholipase D acts resemble the conditions found in the oil industrySe evaluaron dos métodos para determinar la actividad de la fosfolipasa D en soja debido a que existe discrepancia entre los resultados publicados. Un método se basa en la extracción de la enzima de la harina resultante de la molienda del grano de soja entero, cuantificando la actividad sobre el extracto. En el otro método, la cuantificación se realiza sobre la harina del grano entero molido, sin extraer la enzima. En el método de extracción se optimizaron tanto el tiempo como el número de extracciones. Los mayores valores de actividad de la fosfolipasa D se obtuvieron por el método sin extracción de la enzima. Este método es más simple, exige menos tiempo de ejecución y las condiciones del medio en que actúa la fosfolipasa D se asemejan a las condiciones encontradas en la industria aceitera.

  5. Soft-tissues Image Processing: Comparison of Traditional Segmentation Methods with 2D active Contour Methods

    Science.gov (United States)

    Mikulka, J.; Gescheidtova, E.; Bartusek, K.

    2012-01-01

    The paper deals with modern methods of image processing, especially image segmentation, classification and evaluation of parameters. It focuses primarily on processing medical images of soft tissues obtained by magnetic resonance tomography (MR). It is easy to describe edges of the sought objects using segmented images. The edges found can be useful for further processing of monitored object such as calculating the perimeter, surface and volume evaluation or even three-dimensional shape reconstruction. The proposed solutions can be used for the classification of healthy/unhealthy tissues in MR or other imaging. Application examples of the proposed segmentation methods are shown. Research in the area of image segmentation focuses on methods based on solving partial differential equations. This is a modern method for image processing, often called the active contour method. It is of great advantage in the segmentation of real images degraded by noise with fuzzy edges and transitions between objects. In the paper, results of the segmentation of medical images by the active contour method are compared with results of the segmentation by other existing methods. Experimental applications which demonstrate the very good properties of the active contour method are given.

  6. An Autoregressive Method for Simulation Output Analysis.

    Science.gov (United States)

    1982-12-01

    Spectral Density Function 24 3 THE AUTOREGRESSIVE METHOD AND ITS APPLICATIONS...precision of point estimates can be approximated arbitrarily closely by the spectral density function at zero of a finite order autoregressive process...also develop some approximation theorems for continuous spectral density function . It is then demonstrated that a continuous spectral density function

  7. Simplified Processing Method for Meter Data Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Fowler, Kimberly M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Colotelo, Alison H. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Downs, Janelle L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Ham, Kenneth D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Henderson, Jordan W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Montgomery, Sadie A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Vernon, Christopher R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Parker, Steven A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-11-01

    Simple/Quick metered data processing method that can be used for Army Metered Data Management System (MDMS) and Logistics Innovation Agency data, but may also be useful for other large data sets. Intended for large data sets when analyst has little information about the buildings.

  8. Analysis of the sweeped actuator line method

    Directory of Open Access Journals (Sweden)

    Nathan Jörn

    2015-01-01

    Full Text Available The actuator line method made it possible to describe the near wake of a wind turbine more accurately than with the actuator disk method. Whereas the actuator line generates the helicoidal vortex system shed from the tip blades, the actuator disk method sheds a vortex sheet from the edge of the rotor plane. But with the actuator line come also temporal and spatial constraints, such as the need for a much smaller time step than with actuator disk. While the latter one only has to obey the Courant-Friedrichs-Lewy condition, the former one is also restricted by the grid resolution and the rotor tip-speed. Additionally the spatial resolution has to be finer for the actuator line than with the actuator disk, for well resolving the tip vortices. Therefore this work is dedicated to examining a method in between of actuator line and actuator disk, which is able to model the transient behaviour, such as the rotating blades, but which also relaxes the temporal constraint. Therefore a larger time-step is used and the blade forces are swept over a certain area. The main focus of this article is on the aspect of the blade tip vortex generation in comparison with the standard actuator line and actuator disk.

  9. MULTIPHYSICAL ANALYSIS METHODS OF TRANSPORT MACHINES

    Directory of Open Access Journals (Sweden)

    L. Avtonomova

    2009-01-01

    Full Text Available The complex of theoretical, calculable and applied questions of elements transport machine are studied. Coupled-field analyses are useful for solving problems where the coupled interaction of phenomena from various disciplines of physical science is significant. There are basically 3 methods of coupling distinguished by the finite element formulation techniques used to develop the matrix equations.

  10. Review of Methods of Critical Discourse Analysis (second edition)

    Institute of Scientific and Technical Information of China (English)

    邵晓巍

    2014-01-01

    This article, through giving an overview of Methods of Critical Discourse Analysis(second edition), introduces six methodology of doing Critical Discourse Analysis. It is hoped that this article will help those interested in CDA better usher into this field.

  11. Statistical methods for astronomical data analysis

    CERN Document Server

    Chattopadhyay, Asis Kumar

    2014-01-01

    This book introduces “Astrostatistics” as a subject in its own right with rewarding examples, including work by the authors with galaxy and Gamma Ray Burst data to engage the reader. This includes a comprehensive blending of Astrophysics and Statistics. The first chapter’s coverage of preliminary concepts and terminologies for astronomical phenomenon will appeal to both Statistics and Astrophysics readers as helpful context. Statistics concepts covered in the book provide a methodological framework. A unique feature is the inclusion of different possible sources of astronomical data, as well as software packages for converting the raw data into appropriate forms for data analysis. Readers can then use the appropriate statistical packages for their particular data analysis needs. The ideas of statistical inference discussed in the book help readers determine how to apply statistical tests. The authors cover different applications of statistical techniques already developed or specifically introduced for ...

  12. Physical Activity Recognition with Mobile Phones: Challenges, Methods, and Applications

    Science.gov (United States)

    Yang, Jun; Lu, Hong; Liu, Zhigang; Boda, Péter Pál

    In this book chapter, we present a novel system that recognizes and records the physical activity of a person using a mobile phone. The sensor data is collected by built-in accelerometer sensor that measures the motion intensity of the device. The system recognizes five everyday activities in real-time, i.e., stationary, walking, running, bicycling, and in vehicle. We first introduce the sensor's data format, sensor calibration, signal projection, feature extraction, and selection methods. Then we have a detailed discussion and comparison of different choices of feature sets and classifiers. The design and implementation of one prototype system is presented along with resource and performance benchmark on Nokia N95 platform. Results show high recognition accuracies for distinguishing the five activities. The last part of the chapter introduces one demo application built on top of our system, physical activity diary, and a selection of potential applications in mobile wellness, mobile social sharing and contextual user interface domains.

  13. Iso standardization of theoretical activity evaluation method for low and intermediate level activated waste generated at nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Makoto Kashiwagi [JGC, Yokohama, 220-6001 (Japan); Garamszeghy, Mike [NWMO, Toronto, Ontario, M4T 2S3 (Canada); Lantes, Bertrand; Bonne, Sebastien [EDF UTO, 93192 Noisy le Grand (France); Pillette-Cousin, Lucien [AREVA TA, 91192 Gif-sur-Yvette (France); Leganes, Jose Luis [ENRESA, 28043 Madrid (Spain); Volmert, Ben [NAGRA, CH-5430 Wettingen (Switzerland); James, David W. [DW James Consulting, North Oaks, MN 55127 (United States)

    2013-07-01

    Disposal of low-and intermediate-level activated waste generated at nuclear power plants is being planned or carried out in many countries. The radioactivity concentrations and/or total quantities of long-lived, difficult-to-measure nuclides (DTM nuclides), such as C-14, Ni-63, Nb-94, α emitting nuclides etc., are often restricted by the safety case for a final repository as determined by each country's safety regulations, and these concentrations or amounts are required to be known and declared. With respect to waste contaminated by contact with process water, the Scaling Factor method (SF method), which is empirically based on sampling and analysis data, has been applied as an important method for determining concentrations of DTM nuclides. This method was standardized by the International Organization for Standardization (ISO) and published in 2007 as ISO21238 'Scaling factor method to determine the radioactivity of low and intermediate-level radioactive waste packages generated at nuclear power plants' [1]. However, for activated metal waste with comparatively high concentrations of radioactivity, such as may be found in reactor control rods and internal structures, direct sampling and radiochemical analysis methods to evaluate the DTM nuclides are limited by access to the material and potentially high personnel radiation exposure. In this case, theoretical calculation methods in combination with empirical methods based on remote radiation surveys need to be used to best advantage for determining the disposal inventory of DTM nuclides while minimizing exposure to radiation workers. Pursuant to this objective a standard for the theoretical evaluation of the radioactivity concentration of DTM nuclides in activated waste, is in process through ISO TC85/SC5 (ISO Technical Committee 85: Nuclear energy, nuclear technologies, and radiological protection; Subcommittee 5: Nuclear fuel cycle). The project team for this ISO standard was formed in 2011 and

  14. Planning and Optimization Methods for Active Distribution Systems

    DEFF Research Database (Denmark)

    Abbey, Chad; Baitch, Alex; Bak-Jensen, Birgitte

    ”. This report assesses the various requirements to facilitate the transition towards active distribution systems (ADSs). Specifically, the report starts from a survey of requirements of planning methodologies and identifies a new framework and methodologies for short, medium and long term models for active...... in the distribution business since the exploitation of existing assets with Advanced Automation and Control may be a valuable alternative to network expansion or reinforcement. Information and communication technology (ICT) cannot be considered as a simple add-on of the power system and simultaneous analysis (co...

  15. Collection and analysis of active particles

    Energy Technology Data Exchange (ETDEWEB)

    DeLong, C.W.

    1950-01-27

    When it became apparent that particles were emanating from the stacks of the separations plants, it become important that the source, size, activity and composition of the particles be determined in order to evaluate the hazard to persons working in and neer the stack areas. The present report will give the results of radiochemical analysis of particles collected by electrostatic precipitation from ``B`` plant canyon ventilation air, not from the off-gas ventilation line. Of importance is the fact the particles analyzed consist not only of particles from the ventilation air but also, unavoidably, of rust from the iron manifold used to conduct the gases to the precipitator. This makes a determination of the activity versus weight ratio impossible, but should not invalidate the radiochemical data.

  16. Synthetic Methods, Chemistry, and the Anticonvulsant Activity of Thiadiazoles

    Directory of Open Access Journals (Sweden)

    Bhawna Sharma

    2013-01-01

    Full Text Available The chemistry of heterocyclic compounds has been an interesting field of study for a long time. Heterocyclic nucleus 1,3,4-thiadiazole constitutes an important class of compounds for new drug development. The synthesis of novel thiadiazole derivatives and investigation of their chemical and biological behavior have gained more importance in recent decades. The search for antiepileptic compounds with more selective activity and lower toxicity continues to be an active area of intensive investigation in medicinal chemistry. During the recent years, there has been intense investigation of different classes of thiadiazole compounds, many of which possess extensive pharmacological activities, namely, antimicrobial activity, anticonvulsant, antifungal antidiabetic, anti-inflammatory, antioxidant, and antituberculosis activities, and so forth. The resistance towards available drugs is rapidly becoming a major worldwide problem. The need to design new compounds to deal with this resistance has become one of the most important areas of research today. Thiadiazole is a versatile moiety that exhibits a wide variety of biological activities. Thiadiazole moiety acts as “hydrogen binding domain” and “two-electron donor system.” It also acts as a constrained pharmacophore. On the basis of the reported literature, we study here thiadiazole compounds and their synthetic methods chemistry and anticonvulsant activity.

  17. Origin identification for Cantona, Puebla, obsidians by the analysis method of neutron activation (NAA); Identificacion de procedencia para obsidianas de Cantona, Puebla, por el metodo de analisis por activacion neutronica (AAN)

    Energy Technology Data Exchange (ETDEWEB)

    Tellez N, A. L.

    2013-07-01

    There are tests that most of the obsidian worked in the workshops of Cantona, Puebla, is coming from the mineral deposits of Oyameles-Zaragoza, but also has been detected obsidian that macroscopically belongs to other mineral deposits. The present work has as purpose to determine the provenance of an obsidian sample obtained in the Cantona Site to know if there was the presence of obsidian of other mineral deposits. For the study the neutron activation analysis was used to identify the presence of other deposits. An explanation on the treatment to the selected pieces is included, the preparation of the same ones for its irradiation in the nuclear reactor, the counting and statistical study of the results. Finally the results of the selected samples are presented, indicating their origin places, that time comes and the interpretation of the results is given. (Author)

  18. Updated Methods for Seed Shape Analysis

    Directory of Open Access Journals (Sweden)

    Emilio Cervantes

    2016-01-01

    Full Text Available Morphological variation in seed characters includes differences in seed size and shape. Seed shape is an important trait in plant identification and classification. In addition it has agronomic importance because it reflects genetic, physiological, and ecological components and affects yield, quality, and market price. The use of digital technologies, together with development of quantification and modeling methods, allows a better description of seed shape. Image processing systems are used in the automatic determination of seed size and shape, becoming a basic tool in the study of diversity. Seed shape is determined by a variety of indexes (circularity, roundness, and J index. The comparison of the seed images to a geometrical figure (circle, cardioid, ellipse, ellipsoid, etc. provides a precise quantification of shape. The methods of shape quantification based on these models are useful for an accurate description allowing to compare between genotypes or along developmental phases as well as to establish the level of variation in different sets of seeds.

  19. Robustness analysis method for orbit control

    Science.gov (United States)

    Zhang, Jingrui; Yang, Keying; Qi, Rui; Zhao, Shuge; Li, Yanyan

    2017-08-01

    Satellite orbits require periodical maintenance due to the presence of perturbations. However, random errors caused by inaccurate orbit determination and thrust implementation may lead to failure of the orbit control strategy. Therefore, it is necessary to analyze the robustness of the orbit control methods. Feasible strategies which are tolerant to errors of a certain magnitude can be developed to perform reliable orbit control for the satellite. In this paper, first, the orbital dynamic model is formulated by Gauss' form of the planetary equation using the mean orbit elements; the atmospheric drag and the Earth's non-spherical perturbations are taken into consideration in this model. Second, an impulsive control strategy employing the differential correction algorithm is developed to maintain the satellite trajectory parameters in given ranges. Finally, the robustness of the impulsive control method is analyzed through Monte Carlo simulations while taking orbit determination error and thrust error into account.

  20. Decision making based on data analysis methods

    OpenAIRE

    Sirola, Miki; Sulkava, Mika

    2016-01-01

    This technical report is based on four our recent articles:"Data fusion of pre-election gallups and polls for improved support estimates", "Analyzing parliamentary elections based on voting advice application data", "The Finnish car rejection reasons shown in an interactive SOM visualization tool", and "Network visualization of car inspection data using graph layout". Neural methods are applied in political and technical decision making. We introduce decision support schemes based on Self-Org...

  1. Research on Turbine Flowfield Analysis Methods.

    Science.gov (United States)

    1985-01-01

    convergnece. A recent review paper by Henrici (Reference 14) calls attention to the applicability of under-relaxation in this problem. When the solidity...coefficients are written as +I •.- ...- .. Then the basic equation can be split into its real and imaginary parts as: ’ ".. 14. Henrici , P., "Fast...Mapping of Nearly Circular Regions", Quarterly of Applied Mathematics 3, (1945) pp. 12-28. - "-, 14. Henrici , P., "Fast Fourier Methods in Computational

  2. Geometrical Methods for Power Network Analysis

    CERN Document Server

    Bellucci, Stefano; Gupta, Neeraj

    2013-01-01

    This book is a short introduction to power system planning and operation using advanced geometrical methods. The approach is based on well-known insights and techniques developed in theoretical physics in the context of Riemannian manifolds. The proof of principle and robustness of this approach is examined in the context of the IEEE 5 bus system. This work addresses applied mathematicians, theoretical physicists and power engineers interested in novel mathematical approaches to power network theory.

  3. Adaptive Nodal Transport Methods for Reactor Transient Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Thomas Downar; E. Lewis

    2005-08-31

    Develop methods for adaptively treating the angular, spatial, and time dependence of the neutron flux in reactor transient analysis. These methods were demonstrated in the DOE transport nodal code VARIANT and the US NRC spatial kinetics code, PARCS.

  4. Kernel Smoothing Methods for Non-Poissonian Seismic Hazard Analysis

    Science.gov (United States)

    Woo, Gordon

    2017-04-01

    For almost fifty years, the mainstay of probabilistic seismic hazard analysis has been the methodology developed by Cornell, which assumes that earthquake occurrence is a Poisson process, and that the spatial distribution of epicentres can be represented by a set of polygonal source zones, within which seismicity is uniform. Based on Vere-Jones' use of kernel smoothing methods for earthquake forecasting, these methods were adapted in 1994 by the author for application to probabilistic seismic hazard analysis. There is no need for ambiguous boundaries of polygonal source zones, nor for the hypothesis of time independence of earthquake sequences. In Europe, there are many regions where seismotectonic zones are not well delineated, and where there is a dynamic stress interaction between events, so that they cannot be described as independent. From the Amatrice earthquake of 24 August, 2016, the subsequent damaging earthquakes in Central Italy over months were not independent events. Removing foreshocks and aftershocks is not only an ill-defined task, it has a material effect on seismic hazard computation. Because of the spatial dispersion of epicentres, and the clustering of magnitudes for the largest events in a sequence, which might all be around magnitude 6, the specific event causing the highest ground motion can vary from one site location to another. Where significant active faults have been clearly identified geologically, they should be modelled as individual seismic sources. The remaining background seismicity should be modelled as non-Poissonian using statistical kernel smoothing methods. This approach was first applied for seismic hazard analysis at a UK nuclear power plant two decades ago, and should be included within logic-trees for future probabilistic seismic hazard at critical installations within Europe. In this paper, various salient European applications are given.

  5. Evaluating Temporal Analysis Methods Using Residential Burglary Data

    Directory of Open Access Journals (Sweden)

    Martin Boldt

    2016-08-01

    Full Text Available Law enforcement agencies, as well as researchers rely on temporal analysis methods in many crime analyses, e.g., spatio-temporal analyses. A number of temporal analysis methods are being used, but a structured comparison in different configurations is yet to be done. This study aims to fill this research gap by comparing the accuracy of five existing, and one novel, temporal analysis methods in approximating offense times for residential burglaries that often lack precise time information. The temporal analysis methods are evaluated in eight different configurations with varying temporal resolution, as well as the amount of data (number of crimes available during analysis. A dataset of all Swedish residential burglaries reported between 2010 and 2014 is used (N = 103,029. From that dataset, a subset of burglaries with known precise offense times is used for evaluation. The accuracy of the temporal analysis methods in approximating the distribution of burglaries with known precise offense times is investigated. The aoristic and the novel aoristic e x t method perform significantly better than three of the traditional methods. Experiments show that the novel aoristic e x t method was most suitable for estimating crime frequencies in the day-of-the-year temporal resolution when reduced numbers of crimes were available during analysis. In the other configurations investigated, the aoristic method showed the best results. The results also show the potential from temporal analysis methods in approximating the temporal distributions of residential burglaries in situations when limited data are available.

  6. MODERN METHODS OF EVALUATING THE PRODUCTIVITY OF THE RESEARCH ACTIVITY

    Directory of Open Access Journals (Sweden)

    Romanov D. A.

    2015-04-01

    Full Text Available The purpose of the research is development of the new methods of diagnostic the research activities productivity. It is known, that for the evaluation the productivity of a scientist we usually use a well-known index of Hirsch, the introduction of which in 2005 was a significant step forward compared with application of this index as the ratio of the number of references to works of scientist and publications themselves. At the same time even h-index as an indicator is not flawless, the main flaw is weak differential ability: a number of links to the most cited publications of the scientific worker does not matter after reaching a certain threshold. It is necessary to develop a method of estimating the productivity of scientific worker, which preserves dignities of h-index and removes its shortcomings. This will allow evaluating the productivity of research activities more objectively. Methodological bases of the research: a systematic approach (considering the science as a social institution in close connection with the society as a whole, a metasystem approach (considering the results of the scientific activities as a metasystem, i.e. the system with relatively independent components, probabilistic and statistical approach (considering the research activities as the random process, a synergistic approach (considering science like a self-organized system qualimetric approach (considering the productivity of scientific activity as latent variables that reflect a variety of criteria

  7. An Irregular Wave Maker of Active Absorption with VOF Method

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A numerical irregular wave flume with active absorption of re-reflected waves is simulated by use of volume of fluid (VOF) method. An active absorbing wave-maker based on linear wave-theory is set on the left boundary of the wave flume. The progressive waves and the absorbing waves are generated simultaneously at the active wave generating-absorbing boundary. The absorbing waves are generated to eliminate the waves coming back to the generating boundary due to reflection from the outflow boundary and the structures. SIRW method proposed by Frigaard and Brorsen (1995) is used to separate the incident waves and reflected waves. The digital filters are designed based on the surface elevation signals of the two wave gauges. The corrected velocity of the wave-maker paddle is the output from the digital filter in real time. The numerical results of regular and irregular waves by the active absorbing-generating boundary are compared with the numerical results by the ordinary generating boundary to verify the performance of the active absorbing generator boundary. The differences between the initial incident waves and the estimated incident waves are analyzed.

  8. Development and coupling analysis of active skin antenna

    Science.gov (United States)

    Zhou, Jinzhu; Huang, Jin; He, Qingqang; Tang, Baofu; Song, Liwei

    2017-02-01

    An active skin antenna is a multifunctional composite structure that can provide load-bearing structure and steerable beam pointing functions, and is usually installed in the structural surface of aircraft, warships, and armored vehicles. This paper presents an innovative design of the active skin antenna, which consists of a package layer, control and signal processing layer, and RF (radio frequency) layer. The RF layer is fabricated by low temperature co-fired ceramics, with 64 microstrip antenna elements, tile transmitting and receiving modules, microchannel heat sinks, and feeding networks integrated into a functional block 2.8 mm thick. In this paper, a full-sized prototype of an active skin antenna was designed, fabricated, and tested. Moreover, a coupling analysis method was presented to evaluate the mechanical and electromagnetic performance of the active skin antenna subjected to aerodynamic loads. A deformed experimental system was built to validate the effectiveness of the coupling analysis method, which was also implemented to evaluate the performance of the active skin antenna when subjected to aerodynamic pressure. The fabricated specimen demonstrated structural configuration feasibility, and superior environmental load resistance.

  9. Design Method of Active Disturbance Rejection Variable Structure Control System

    Directory of Open Access Journals (Sweden)

    Yun-jie Wu

    2015-01-01

    Full Text Available Based on lines cluster approaching theory and inspired by the traditional exponent reaching law method, a new control method, lines cluster approaching mode control (LCAMC method, is designed to improve the parameter simplicity and structure optimization of the control system. The design guidelines and mathematical proofs are also given. To further improve the tracking performance and the inhibition of the white noise, connect the active disturbance rejection control (ADRC method with the LCAMC method and create the extended state observer based lines cluster approaching mode control (ESO-LCAMC method. Taking traditional servo control system as example, two control schemes are constructed and two kinds of comparison are carried out. Computer simulation results show that LCAMC method, having better tracking performance than the traditional sliding mode control (SMC system, makes the servo system track command signal quickly and accurately in spite of the persistent equivalent disturbances and ESO-LCAMC method further reduces the tracking error and filters the white noise added on the system states. Simulation results verify the robust property and comprehensive performance of control schemes.

  10. Extrudate Expansion Modelling through Dimensional Analysis Method

    DEFF Research Database (Denmark)

    A new model framework is proposed to correlate extrudate expansion and extrusion operation parameters for a food extrusion cooking process through dimensional analysis principle, i.e. Buckingham pi theorem. Three dimensionless groups, i.e. energy, water content and temperature, are suggested...... to describe the extrudates expansion. From the three dimensionless groups, an equation with three experimentally determined parameters is derived to express the extrudate expansion. The model is evaluated with whole wheat flour and aquatic feed extrusion experimental data. The average deviations...

  11. Casting defects analysis by the Pareto method

    Directory of Open Access Journals (Sweden)

    B. Borowiecki

    2011-07-01

    Full Text Available On the basis of receive results formed of diagram Pareto Lorenz. On the basis of receive graph it affirmed, that for 70% general number casting defects answered 3 defects (9 contribution – 100% defects. For 70% general number defects of influence it has three type of causes: sand holes, porosity and slaginclusions. Thedefects show that it is necessary to take up construction gatingsystem. The remaining 8 causes have been concerned only 25%, with general number of casting defects. Analysis of receive results permit to determine of direction of correct actions in order to eliminate or to limit the most defects.

  12. A comparison of methods to determine tannin acyl hydrolase activity

    Directory of Open Access Journals (Sweden)

    Cristóbal Aguilar

    1999-01-01

    Full Text Available Six methods to determine the activity of tannase produced by Aspergillus niger Aa-20 on polyurethane foam by solid state fermentation, which included two titrimetric techniques, three spectrophotometric methods and one HPLC assay were tested and compared. All methods assayed enabled the measurement of extracellular tannase activity. However, only five were useful to evaluate intracellular tannase activity. Studies on the effect of pH on tannase extraction demonstrated that tannase activity was considerably under-estimated when its extraction was carried out at pH values below 5.5 and above 6.0. Results showed that the HPLC technique and the modified Bajpai and Patil methods presented several advantages in comparison to the other methods tested.Seis métodos para determinar a atividade de tannase produzida por Aspergillus niger O Aa-20 em espuma de polyuretano por fermentação em estado sólido foram estudados. Duas técnicas titulométricas , três métodos spectrofotométricos e um método por HPLC foram testados e comparados. Todos os métodos testados permitiram determinar a atividade da tannase produzida extracelularmente. Entretanto, somente cinco se mostraram úteis para avaliar a atividade da tannase produzida intracelularmente. Os estudos do efeito do pH na extração de tannase demonstraram que a atividade de tannase era consideravelmente subestimada quando sua extração foi executada em valores de pH inferiores a 5.5 e superior a pH 6.0. Os resultados demostraram que a técnica de HPLC o método Bajpai and Patil modificado apresentam várias vantagens em comparação aos outros métodos testados.

  13. Modified Homotopy Analysis Method for Nonlinear Fractional Partial Differential Equations

    Directory of Open Access Journals (Sweden)

    D. Ziane

    2017-05-01

    Full Text Available In this paper, a combined form of natural transform with homotopy analysis method is proposed to solve nonlinear fractional partial differential equations. This method is called the fractional homotopy analysis natural transform method (FHANTM. The FHANTM can easily be applied to many problems and is capable of reducing the size of computational work. The fractional derivative is described in the Caputo sense. The results show that the FHANTM is an appropriate method for solving nonlinear fractional partial differentia equation.

  14. Uranium analysis by neutron induced fissionography method using solid state nuclear track detectors

    CERN Document Server

    Akyuez, T; Guezel, T; Akyuz, S

    1999-01-01

    In this study total twenty samples (eight reference materials and twelve sediment samples) were analysed for their uranium content which is in the range of 1-17 mu g/g, by neutron induced fissionography (NIF) method using solid state nuclear track detectors (SSNTDs) in comparison with the results of neutron activation analysis (NAA), delayed neutron counting (DNC) technique or fluorometric method. It is found that NIF method using SSNTDs is very sensitive for analysis of uranium.

  15. Analysis of Vibration Diagnostics Methods for Induction Motors

    Directory of Open Access Journals (Sweden)

    A. Kalinov

    2012-01-01

    Full Text Available The paper presents an analysis of existing vibration diagnostics methods. In order to evaluate an efficiency of method application the following criteria have been proposed: volume of input data required for establishing diagnosis, data content, software and hardware level, execution time for vibration diagnostics. According to the mentioned criteria a classification of vibration diagnostics methods for determination of their advantages and disadvantages, search for their development and improvement has been presented in paper. The paper contains a comparative estimation of methods in accordance with the proposed  criteria. According to this estimation the most efficient methods are a spectral analysis and spectral analysis of the vibration signal envelope.

  16. The Constant Comparative Method of Qualitative Analysis

    Directory of Open Access Journals (Sweden)

    Barney G. Glaser, Ph.D.

    2008-11-01

    Full Text Available Currently, the general approaches to the analysis of qualitative data are these:1. If the analyst wishes to convert qualitative data into crudely quantifiable form so that he can provisionally test a hypothesis, he codes the data first and then analyzes it. He makes an effort to code “all relevant data [that] can be brought to bear on a point,” and then systematically assembles, assesses and analyzes these data in a fashion that will “constitute proof for a given proposition.”i2. If the analyst wishes only to generate theoretical ideasnew categories and their properties, hypotheses and interrelated hypotheses- he cannot be confined to the practice of coding first and then analyzing the data since, in generating theory, he is constantly redesigning and reintegrating his theoretical notions as he reviews his material.ii Analysis with his purpose, but the explicit coding itself often seems an unnecessary, burdensome task. As a result, the analyst merely inspects his data for new properties of his theoretical categories, and writes memos on these properties.We wish to suggest a third approach

  17. Time Slice Analysis Method Based on OTCA Used in fMRI Weak Signal Function Extraction

    Institute of Scientific and Technical Information of China (English)

    LUO Sen-lin; LI Li; ZHANG Xin-li; ZHANG Tie-mei

    2007-01-01

    The original temporal clustering analysis (OTCA) is an effective technique for obtaining brain activation maps when the timing and location of the activation are completely unknown, but its deficiency of sensitivity is exposed in processing brain activation signal which is relatively weak. The time slice analysis method based on OTCA is proposed considering the weakness of the functional magnetic resonance imaging (fMRI) signal of the rat model. By dividing the stimulation period into several time slices and analyzing each slice to detect the activated pixels respectively after the background removal, the sensitivity is significantly improved. The inhibitory response in the hypothalamus after glucose loading is detected successfully with this method in the experiment on rat. Combined with the OTCA method, the time slice analysis method based on OTCA is effective on detecting when, where and which type of response will happen after stimulation, even if the fMRI signal is weak.

  18. Paired comparisons analysis: an axiomatic approach to ranking methods

    NARCIS (Netherlands)

    Gonzalez-Diaz, J.; Hendrickx, Ruud; Lohmann, E.R.M.A.

    2014-01-01

    In this paper we present an axiomatic analysis of several ranking methods for general tournaments. We find that the ranking method obtained by applying maximum likelihood to the (Zermelo-)Bradley-Terry model, the most common method in statistics and psychology, is one of the ranking methods that per

  19. PHYTOCHEMICAL ANALYSIS AND ANTIMICROBIAL ACTIVITY OF CASIA OCCIDENTALIS (L

    Directory of Open Access Journals (Sweden)

    Venkanna Lunavath

    2013-02-01

    Full Text Available The trend of using natural products has increased and the active plant extracts are frequently screened for new drug discoveries. The present study deals with the screening of Casia occidentalis leaves for their antimicrobial activity against various strains of bacteria. Plant Cassia occidentalis belongs to family Caesalpiniaceae, is a diffuse offensively odorous under shrub. Casia occidentalis were shade dried, powered and was extracted using solvents Methanol. The antimicrobial activity test performed by the disc diffusion method. Preliminary phytochemical analysis of the plant extracts fractions of HXF, CTF, CFF and AQF showed the presence of carbohydrates, amino acids, phytosterols, fixed oils and phenolic compounds. The AQF fraction of C. occidentalis showed high activity across pseudomonas aeuruginosa and staphylococcus aureus bacteria. The present study indicates the potential usefulness of Casia occidentalis leaves in the treatment of various diseases caused by micro-organisms.

  20. A method for determining Am-241 activity for large area contamination.

    Science.gov (United States)

    Wilhelm, Emilien; Arbor, Nicolas; Gutierrez, Sébastien; Ménard, Stéphanie; Nourreddine, Abdel-Mjid

    2017-01-01

    Airborne gamma-ray spectrometry system HELINUC™ is used for different missions. Although well-developed for estimation of high energy emitters' activity, it is rarely used for low energy emitters. A new method for the determination of Am-241 activity over extended sites based both on statistical analysis of spectra and deconvolution of Am-241 signal with a reference library is presented. Results show a lowering of the detection threshold and a good agreement with ground level measurements.

  1. Vulnerability analysis of three remote voting methods

    CERN Document Server

    Enguehard, Chantal

    2009-01-01

    This article analyses three methods of remote voting in an uncontrolled environment: postal voting, internet voting and hybrid voting. It breaks down the voting process into different stages and compares their vulnerabilities considering criteria that must be respected in any democratic vote: confidentiality, anonymity, transparency, vote unicity and authenticity. Whether for safety or reliability, each vulnerability is quantified by three parameters: size, visibility and difficulty to achieve. The study concludes that the automatisation of treatments combined with the dematerialisation of the objects used during an election tends to substitute visible vulnerabilities of a lesser magnitude by invisible and widespread vulnerabilities.

  2. Mathematical methods of analysis of biopolymer sequences

    CERN Document Server

    Gindikin, S G

    1992-01-01

    This collection contains papers by participants in the seminar on mathematical methods in molecular biology who worked for several years at the Laboratory of Molecular Biology and Bioorganic Chemistry (now the Institute of Physical and Chemical Problems in Biology) at Moscow State University. The seminar united mathematicians and biologists around the problems of biological sequences. The collection includes original results as well as expository material and spans a range of perspectives, from purely mathematical problems to algorithms and their computer realizations. For this reason, the book is of interest to mathematicians, statisticians, biologists, and computational scientists who work with biopolymer sequences.

  3. Tournament Methods for WLAN: Analysis and Efficiency

    Science.gov (United States)

    Galtier, Jérôme

    In the context of radio distributed networks, we present a generalized approach for Medium Access Control (MAC) with a fixed congestion window. Our protocol is quite simple to analyze and can be used in a lot of different situations. We give mathematical evidence showing that our performance is asymptotically tight. We also place ourselves in the WiFi and WiMAX frameworks, and discuss experimental results showing acollision reduction of 14% to 21% compared to the best-known methods. We discuss channel capacity improvement and fairness considerations.

  4. Application of Statistical Methods to Activation Analytical Results near the Limit of Detection

    DEFF Research Database (Denmark)

    Heydorn, Kaj; Wanscher, B.

    1978-01-01

    Reporting actual numbers instead of upper limits for analytical results at or below the detection limit may produce reliable data when these numbers are subjected to appropriate statistical processing. Particularly in radiometric methods, such as activation analysis, where individual standard...... deviations of analytical results may be estimated, improved discrimination may be based on the Analysis of Precision. Actual experimental results from a study of the concentrations of arsenic in human skin demonstrate the power of this principle....

  5. Molten Salt Breeder Reactor Analysis Methods

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jinsu; Jeong, Yongjin; Lee, Deokjung [Ulsan National Institute of Science and Technology, Ulsan (Korea, Republic of)

    2015-05-15

    Utilizing the uranium-thorium fuel cycle shows considerable potential for the possibility of MSR. The concept of MSBR should be revised because of molten salt reactor's advantage such as outstanding neutron economy, possibility of continuous online reprocessing and refueling, a high level of inherent safety, and economic benefit by keeping off the fuel fabrication process. For the development of MSR research, this paper provides the MSBR single-cell, two-cell and whole core model for computer code input, and several calculation results including depletion calculation of each models. The calculations are carried out by using MCNP6, a Monte Carlo computer code, which has CINDER90 for depletion calculation using ENDF-VII nuclear data. From the calculation results of various reactor design parameters, the temperature coefficients are all negative at the initial state and MTC becomes positive at the equilibrium state. From the results of core rod worth, the graphite control rod alone cannot makes the core subcritical at initial state. But the equilibrium state, the core can be made subcritical state only by graphite control rods. Through the comparison of the results of each models, the two-cell method can represent the MSBR core model more accurately with a little more computational resources than the single-cell method. Many of the thermal spectrum MSR have adopted a multi-region single-fluid strategy.

  6. Neutron Field Measurements in Phantom with Foil Activation Methods.

    Science.gov (United States)

    1986-11-29

    jI25 Ii III uumu ullli~ S....- - Lb - w * .qJ’ AD-A 192 122 ulJ. IL (pj DNA-TR-87- 10 N EUTRON FIELD MEASUREMENTS IN PHANTOM WITH FOIL ACTIVATION...SAND II Measurements in Phantom 6 4 The 5-Foil Neutron Dosimetry Method 29 5 Comparison of SAND II and Simple 5-Foil Dosimetry Method 34 6 Thermal ...quite reasonable. The monkey phantom spectrum differs from the NBS U-235 fission spectrum in that the former has a I/E tail plus thermal -neutron peak

  7. ISAR active jamming method based on sinusoidal modulation

    Institute of Scientific and Technical Information of China (English)

    Yu Zhang; Congfeng Liu; Yan Zhu

    2015-01-01

    It is potential y useful to perform deception or cover jamming using the rotating angular reflectors since they can form deception echoes along range and azimuth. Inspired by the cohe-rent jamming and micro-motion modulation, a novel active method is proposed for inverse synthetic aperture radar (ISAR). Radar pulses are sampled and frequency-modulated along azimuth by si-nusoidal signal, and then the jamming signals are retransmitted to the radar and the jamming images are induced after ISAR imaging. Therein, the jamming principle, key parameters and the jamming effect are discussed. The simulated data verify the effectiveness of the jamming method.

  8. Comparative Study Among Lease Square Method, Steepest Descent Method, and Conjugate Gradient Method for Atmopsheric Sounder Data Analysis

    Directory of Open Access Journals (Sweden)

    Kohei Arai

    2013-09-01

    Full Text Available Comparative study among Least Square Method: LSM, Steepest Descent Method: SDM, and Conjugate Gradient Method: CGM for atmospheric sounder data analysis (estimation of vertical profiles for water vapor is conducted. Through simulation studies, it is found that CGM shows the best estimation accuracy followed by SDM and LSM. Method dependency on atmospheric models is also clarified.

  9. Experimental and analysis methods in radiochemical experiments

    Science.gov (United States)

    Cattadori, C. M.; Pandola, L.

    2016-04-01

    Radiochemical experiments made the history of neutrino physics by achieving the first observation of solar neutrinos (Cl experiment) and the first detection of the fundamental pp solar neutrinos component (Ga experiments). They measured along decades the integral νe charged current interaction rate in the exposed target. The basic operation principle is the chemical separation of the few atoms of the new chemical species produced by the neutrino interactions from the rest of the target, and their individual counting in a low-background counter. The smallness of the expected interaction rate (1 event per day in a ˜ 100 ton target) poses severe experimental challenges on the chemical and on the counting procedures. The main aspects related to the analysis techniques employed in solar neutrino experiments are reviewed and described, with a special focus given to the event selection and the statistical data treatment.

  10. Surface analysis methods in materials science

    CERN Document Server

    Sexton, Brett; Smart, Roger

    1992-01-01

    The idea for this book stemmed from a remark by Philip Jennings of Murdoch University in a discussion session following a regular meeting of the Australian Surface Science group. He observed that a text on surface analysis and applica­ tions to materials suitable for final year undergraduate and postgraduate science students was not currently available. Furthermore, the members of the Australian Surface Science group had the research experience and range of coverage of sur­ face analytical techniques and applications to provide a text for this purpose. A of techniques and applications to be included was agreed at that meeting. The list intended readership of the book has been broadened since the early discussions, particularly to encompass industrial users, but there has been no significant alter­ ation in content. The editors, in consultation with the contributors, have agreed that the book should be prepared for four major groups of readers: - senior undergraduate students in chemistry, physics, metallur...

  11. Experimental and analysis methods in radiochemical experiments

    Energy Technology Data Exchange (ETDEWEB)

    Cattadori, C.M. [INFN, Milano (Italy); Pandola, L. [Laboratori Nazionali del Sud, INFN, Catania (Italy); Gran Sasso Science Institute, INFN, L' Aquila (Italy)

    2016-04-15

    Radiochemical experiments made the history of neutrino physics by achieving the first observation of solar neutrinos (Cl experiment) and the first detection of the fundamental pp solar neutrinos component (Ga experiments). They measured along decades the integral ν{sub e} charged current interaction rate in the exposed target. The basic operation principle is the chemical separation of the few atoms of the new chemical species produced by the neutrino interactions from the rest of the target, and their individual counting in a low-background counter. The smallness of the expected interaction rate (1 event per day in a ∝ 100 ton target) poses severe experimental challenges on the chemical and on the counting procedures. The main aspects related to the analysis techniques employed in solar neutrino experiments are reviewed and described, with a special focus given to the event selection and the statistical data treatment. (orig.)

  12. Novel DTA method for thermal stability analysis

    Energy Technology Data Exchange (ETDEWEB)

    Berty, J.M.; Gandhi, R.J.; Lee, S.

    1986-01-01

    A Differential Thermal Analysis (DTA) technique to study the kinetics of highly exothermic reactions for estimating thermal stability parameters has been developed. The technique involves measuring and analyzing the heat generated due to the reaction from a differential temperature curve. The technique has been tested by studying the kinetics of the reaction between sodium thiosulfate and hydrogen peroxide whose kinetic parameters are already known and whose thermal stability has been analyzed by a different technique. First the envisiones experiment was simulated on computer, then the DTA experimental equipment was designed on the basis of the computer simulation and finally the actual reaction between Na/sub 2/S/sub 2/O/sub 4/ and H/sub 2/O was performed. The satisfactory results demonstrated the feasibility of the DTA technique for estimating the kinetic parameters.

  13. Radiation analysis devices, radiation analysis methods, and articles of manufacture

    Science.gov (United States)

    Roybal, Lyle Gene

    2010-06-08

    Radiation analysis devices include circuitry configured to determine respective radiation count data for a plurality of sections of an area of interest and combine the radiation count data of individual of sections to determine whether a selected radioactive material is present in the area of interest. An amount of the radiation count data for an individual section is insufficient to determine whether the selected radioactive material is present in the individual section. An article of manufacture includes media comprising programming configured to cause processing circuitry to perform processing comprising determining one or more correction factors based on a calibration of a radiation analysis device, measuring radiation received by the radiation analysis device using the one or more correction factors, and presenting information relating to an amount of radiation measured by the radiation analysis device having one of a plurality of specified radiation energy levels of a range of interest.

  14. 浅议作业成本法在环境成本计算和分摊中的应用%Analysis of activity cost method used in calculation and apportionment of environmental cost

    Institute of Scientific and Technical Information of China (English)

    李琼

    2013-01-01

    在目前传统会计系统下,环境成本直接计算分摊到制造费用,然后由所有产品共同分摊环境成本,造成产品成本信息扭曲。针对这一问题,采用作业成本法,可以通过设置作业成本库,并通过成本动因科学地、合理地确定计量环境成本,从而有效地解决这个问题,有利于管理层利用正确的产品成本信息做出有利于环境效应并具有长远发展能力的产品的决策。%Under current traditional accounting system,environmental cost is directly apportioned to manufacturing cost to be shared by all products thus generating twisted product cost information. To cope with this,activity cost method is employed. It establishes an activity cost pool and then scales environmental cost scientifically and reasonably based on cost drivers. This approach is helpful to decision making by management with correct product cost information,which favors development of a more environment-friendly and lasting product.

  15. A Reliable Method for Rhythm Analysis during Cardiopulmonary Resuscitation

    Directory of Open Access Journals (Sweden)

    U. Ayala

    2014-01-01

    Full Text Available Interruptions in cardiopulmonary resuscitation (CPR compromise defibrillation success. However, CPR must be interrupted to analyze the rhythm because although current methods for rhythm analysis during CPR have high sensitivity for shockable rhythms, the specificity for nonshockable rhythms is still too low. This paper introduces a new approach to rhythm analysis during CPR that combines two strategies: a state-of-the-art CPR artifact suppression filter and a shock advice algorithm (SAA designed to optimally classify the filtered signal. Emphasis is on designing an algorithm with high specificity. The SAA includes a detector for low electrical activity rhythms to increase the specificity, and a shock/no-shock decision algorithm based on a support vector machine classifier using slope and frequency features. For this study, 1185 shockable and 6482 nonshockable 9-s segments corrupted by CPR artifacts were obtained from 247 patients suffering out-of-hospital cardiac arrest. The segments were split into a training and a test set. For the test set, the sensitivity and specificity for rhythm analysis during CPR were 91.0% and 96.6%, respectively. This new approach shows an important increase in specificity without compromising the sensitivity when compared to previous studies.

  16. A Reliable Method for Rhythm Analysis during Cardiopulmonary Resuscitation

    Science.gov (United States)

    Ayala, U.; Irusta, U.; Ruiz, J.; Eftestøl, T.; Kramer-Johansen, J.; Alonso-Atienza, F.; Alonso, E.; González-Otero, D.

    2014-01-01

    Interruptions in cardiopulmonary resuscitation (CPR) compromise defibrillation success. However, CPR must be interrupted to analyze the rhythm because although current methods for rhythm analysis during CPR have high sensitivity for shockable rhythms, the specificity for nonshockable rhythms is still too low. This paper introduces a new approach to rhythm analysis during CPR that combines two strategies: a state-of-the-art CPR artifact suppression filter and a shock advice algorithm (SAA) designed to optimally classify the filtered signal. Emphasis is on designing an algorithm with high specificity. The SAA includes a detector for low electrical activity rhythms to increase the specificity, and a shock/no-shock decision algorithm based on a support vector machine classifier using slope and frequency features. For this study, 1185 shockable and 6482 nonshockable 9-s segments corrupted by CPR artifacts were obtained from 247 patients suffering out-of-hospital cardiac arrest. The segments were split into a training and a test set. For the test set, the sensitivity and specificity for rhythm analysis during CPR were 91.0% and 96.6%, respectively. This new approach shows an important increase in specificity without compromising the sensitivity when compared to previous studies. PMID:24895621

  17. Emotion recognition method using entropy analysis of EEG signals

    Directory of Open Access Journals (Sweden)

    Seyyed Abed Hosseini

    2011-08-01

    Full Text Available This paper proposes an emotion recognition system using EEG signals, therefore a new approach to emotion state analysis by approximate (ApEn and wavelet entropy (WE is described. We have used EEG signals recorded during emotion in five channels (FP1, FP2, T3, T4 and Pz, under pictures induction environment (calm-neutral and negative excited for participants. After a brief introduction to the concept, the ApEn and WE were extracted from two different EEG time series. The result showed that, the classification accuracy in two emotion states was 73.25% using the support vector machine (SVM classifier. The simulations showed that the classification accuracy is good and the proposed methods are effective. During an emotion, the EEG is less complex compared to the normal, indicating reduction in active neuronal process in the brain.

  18. Evaluation of harmonic detection methods for active power filter applications

    DEFF Research Database (Denmark)

    Asiminoaei, Lucian; Blaabjerg, Frede; Hansen, Steffan

    2005-01-01

    filter is to use a good method for current/voltage reference generation. There exist many implementations supported by different theories (either in time- or frequency-domain), which continuously debate their performances proposing ever better solutions. This paper gives a survey of the common used...... theories. Then, the work here proposes a simulation setup that decouples the harmonic reference generator from the active filter model and its controller. In this way the selected methods can be equally analyzed and compared with respect to their performance, which helps anticipating possible...... implementation issues. The conclusions are collected and a comparison is given at the end, which is useful in deciding the future hardware setup implementation. The comparison shows that the choice of numerical filtering is a key factor for obtaining good accuracies and dynamics for an active filter....

  19. Comparison of a general series expansion method and the homotopy analysis method

    CERN Document Server

    Liu, Cheng-shi

    2011-01-01

    A simple analytic tool namely the general series expansion method is proposed to find the solutions for nonlinear differential equations. By choosing a set of suitable basis functions $\\{e_n(t,t_0)\\}_{n=0}^{+\\infty}$ such that the solution to the equation can be expressed by $u(t)=\\sum_{n=0}^{+\\infty}c_ne_n(t,t_0)$. In general, $t_0$ can control and adjust the convergence region of the series solution such that our method has the same effect as the homotopy analysis method proposed by Liao, but our method is more simple and clear. As a result, we show that the secret parameter $h$ in the homotopy analysis methods can be explained by using our parameter $t_0$. Therefore, our method reveals a key secret in the homotopy analysis method. For the purpose of comparison with the homotopy analysis method, a typical example is studied in detail.

  20. Stochastic back analysis of permeability coefficient using generalized Bayesian method

    Institute of Scientific and Technical Information of China (English)

    Zheng Guilan; Wang Yuan; Wang Fei; Yang Jian

    2008-01-01

    Owing to the fact that the conventional deterministic back analysis of the permeability coefficient cannot reflect the uncertainties of parameters, including the hydraulic head at the boundary, the permeability coefficient and measured hydraulic head, a stochastic back analysis taking consideration of uncertainties of parameters was performed using the generalized Bayesian method. Based on the stochastic finite element method (SFEM) for a seepage field, the variable metric algorithm and the generalized Bayesian method, formulas for stochastic back analysis of the permeability coefficient were derived. A case study of seepage analysis of a sluice foundation was performed to illustrate the proposed method. The results indicate that, with the generalized Bayesian method that considers the uncertainties of measured hydraulic head, the permeability coefficient and the hydraulic head at the boundary, both the mean and standard deviation of the permeability coefficient can be obtained and the standard deviation is less than that obtained by the conventional Bayesian method. Therefore, the present method is valid and applicable.

  1. Analysis of mesoscale forecasts using ensemble methods

    CERN Document Server

    Gross, Markus

    2016-01-01

    Mesoscale forecasts are now routinely performed as elements of operational forecasts and their outputs do appear convincing. However, despite their realistic appearance at times the comparison to observations is less favorable. At the grid scale these forecasts often do not compare well with observations. This is partly due to the chaotic system underlying the weather. Another key problem is that it is impossible to evaluate the risk of making decisions based on these forecasts because they do not provide a measure of confidence. Ensembles provide this information in the ensemble spread and quartiles. However, running global ensembles at the meso or sub mesoscale involves substantial computational resources. National centers do run such ensembles, but the subject of this publication is a method which requires significantly less computation. The ensemble enhanced mesoscale system presented here aims not at the creation of an improved mesoscale forecast model. Also it is not to create an improved ensemble syste...

  2. New analysis method for passive microrheology

    Science.gov (United States)

    Nishi, Kengo; Schmidt, Christoph; Mackintosh, Fred

    Passive microrheology is an experimental technique used to measure the mechanical response of materials from the fluctuations of micron-sized beads embedded in the medium. Microrheology is well suited to study rheological properties of materials that are difficult to obtain in larger amounts and also of materials inside of single cells. In one common approach, one uses the fluctuation-dissipation theorem to obtain the imaginary part of the material response function from the power spectral density of bead displacement fluctuations, while the real part of the response function is calculated using a Kramers-Kronig integral. The high-frequency cut-off of this integral strongly affects the real part of the response function in the high frequency region. Here, we discuss how to obtain more accurate values of the real part of the response function by an alternative method using autocorrelation functions.

  3. Analysis of speech waveform quantization methods

    Directory of Open Access Journals (Sweden)

    Tadić Predrag R.

    2008-01-01

    Full Text Available Digitalization, consisting of sampling and quantization, is the first step in any digital signal processing algorithm. In most cases, the quantization is uniform. However, having knowledge of certain stochastic attributes of the signal (namely, the probability density function, or pdf, quantization can be made more efficient, in the sense of achieving a greater signal to quantization noise ratio. This means that narrower channel bandwidths are required for transmitting a signal of the same quality. Alternatively, if signal storage is of interest, rather than transmission, considerable savings in memory space can be made. This paper presents several available methods for speech signal pdf estimation, and quantizer optimization in the sense of minimizing the quantization error power.

  4. Analysis of the Wing Tsun Punching Methods

    Directory of Open Access Journals (Sweden)

    Jeff Webb

    2012-07-01

    Full Text Available The three punching techniques of Wing Tsun, while few in number, represent an effective approach to striking with the closed fist. At first glance, the rather short stroke of each punch would seem disproportionate to the amount of power it generates. Therefore, this article will discuss the structure and body mechanics of each punch, in addition to the various training methods employed for developing power. Two of the Wing Tsun punches, namely the lifting punch and the hooking punch, are often confused with similar punches found in Western boxing. The key differences between the Wing Tsun and boxing punches, both in form and function, will be discussed. Finally, the strategy for applying the Wing Tsun punches will serve as the greatest factor in differentiating them from the punches of other martial arts styles.

  5. An economic analysis of developmental detection methods.

    Science.gov (United States)

    Glascoe, F P; Foster, E M; Wolraich, M L

    1997-06-01

    To assess the costs and benefits of various approaches to early detection of developmental disabilities. Cost-benefit analyses based on data from previously published studies of developmental screening tests. General pediatric practices and day care centers. A total of 247 parents and their 0- to 6-year-old children-103 from day care centers and 144 from pediatric practices. Licensed psychological examiners administered a screening test of parents' concerns about children's development and one or two direct screening tests: the Denver-II and/or the Battelle Developmental Inventory Screening Test. For the day care sample, examiners also administered to each child measures of intelligence, adaptive behavior, and language. In the pediatric sample, children were administered additional assessments. At the same time, diagnostic measures were administered to a randomly selected subsample to make determinations about developmental status. Each screening method was evaluated for its short-term costs (administration, interpretation, diagnosis, and treatment) and long-term benefits (impact of early intervention on adult functioning as inferred from longitudinal studies by other researchers). When the long-term costs and benefits were considered, none of the approaches emerged as markedly superior to another. When viewing the short-term costs, the various screening approaches differed markedly. The use of parents' concerns was by far the least costly for physicians to administer and interpret. Physicians can incur tremendous expenses when attempting to detect children with developmental problems. Although the benefits of early detection and intervention are substantial, physicians are not well-compensated for providing a critical service to society. Health policymakers and third-party payers must reconsider their minimal investment in early detection by health care providers. Nevertheless, our findings have encouraging implications for practice, because the use of parents

  6. CHAPTER 7. BERYLLIUM ANALYSIS BY NON-PLASMA BASED METHODS

    Energy Technology Data Exchange (ETDEWEB)

    Ekechukwu, A

    2009-04-20

    The most common method of analysis for beryllium is inductively coupled plasma atomic emission spectrometry (ICP-AES). This method, along with inductively coupled plasma mass spectrometry (ICP-MS), is discussed in Chapter 6. However, other methods exist and have been used for different applications. These methods include spectroscopic, chromatographic, colorimetric, and electrochemical. This chapter provides an overview of beryllium analysis methods other than plasma spectrometry (inductively coupled plasma atomic emission spectrometry or mass spectrometry). The basic methods, detection limits and interferences are described. Specific applications from the literature are also presented.

  7. Artifact suppression and analysis of brain activities with electroencephalography signals

    Institute of Scientific and Technical Information of China (English)

    Md. Rashed-Al-Mahfuz; Md. Rabiul Islam; Keikichi Hirose; Md. Khademul Islam Molla

    2013-01-01

    Brain-computer interface is a communication system that connects the brain with computer (or other devices) but is not dependent on the normal output of the brain (i.e., peripheral nerve and muscle). Electro-oculogram is a dominant artifact which has a significant negative influence on further analysis of real electroencephalography data. This paper presented a data adaptive technique for artifact suppression and brain wave extraction from electroencephalography signals to detect regional brain activities. Empirical mode decomposition based adaptive thresholding approach was employed here to suppress the electro-oculogram artifact. Fractional Gaussian noise was used to determine the threshold level derived from the analysis data without any training. The purified electroencephalography signal was composed of the brain waves also called rhythmic components which represent the brain activities. The rhythmic components were extracted from each electroencephalography channel using adaptive wiener filter with the original scale. The regional brain activities were mapped on the basis of the spatial distribution of rhythmic components, and the results showed that different regions of the brain are activated in response to different stimuli. This research analyzed the activities of a single rhythmic component, alpha with respect to different motor imaginations. The experimental results showed that the proposed method is very efficient in artifact suppression and identifying individual motor imagery based on the activities of alpha component.

  8. Hybrid architecture active wavefront sensing and control system, and method

    Science.gov (United States)

    Feinberg, Lee D. (Inventor); Dean, Bruce H. (Inventor); Hyde, Tristram T. (Inventor)

    2011-01-01

    According to various embodiments, provided herein is an optical system and method that can be configured to perform image analysis. The optical system can comprise a telescope assembly and one or more hybrid instruments. The one or more hybrid instruments can be configured to receive image data from the telescope assembly and perform a fine guidance operation and a wavefront sensing operation, simultaneously, on the image data received from the telescope assembly.

  9. THE MODERN MODELS AND METHODS OF DIAGNOSIS THE RESEARCH ACTIVITY OF ACADEMIC AND PEDAGOGICAL COLLECTIVES

    Directory of Open Access Journals (Sweden)

    Loyko V. I.

    2015-10-01

    Full Text Available The purpose of research – the development of models and methods of multiparametrical diagnostic the research activities of scientific and pedagogical collectives of educational institutions. The problematics of research is improving the quality and productivity (the efficiency of research activities in educational institutions. The problem of research is the question of how to objectively and comprehensively (in a complex diagnose the research activities of scientific and pedagogical collectives? The urgency of solving specified problem is caused by the need to ensuring a close relationship between research, methodological and educational activities in educational institutions. We have also to consider the increasing role of clusters in the Russian economy, cooperation and integration levels (steps a system of continuous education, etc. The authors identified the parameters reflecting significance of research activities of the scientific and the pedagogical collectives for the scientific and educational community (social megaenvironmental. When allocating indicators the authors took into account that science - the social and cultural phenomenon and the social institution, and the most important aspect of the significance of the research activity - in the innovative development of various spheres of human activity. The applied methods of research: mathematical modeling; methods of the theory of graphs, sets and relations; methods of "artificial intelligence" and the multi-parameter analysis of systems; methods of quality control (theory of latent variables. Methodological bases of research: systemic, cultural, competence, metasystem, sociological, qualimetric and synergetic approaches

  10. Analysis of construction dynamic plan using fuzzy critical path method

    Directory of Open Access Journals (Sweden)

    Kurij Kazimir V.

    2014-01-01

    Full Text Available Critical Path Method (CPM technique has become widely recognized as valuable tool for the planning and scheduling large construction projects. The aim of this paper is to present an analytical method for finding the Critical Path in the precedence network diagram where the duration of each activity is represented by a trapezoidal fuzzy number. This Fuzzy Critical Path Method (FCPM uses a defuzzification formula for trapezoidal fuzzy number and applies it on the total float (slack time for each activity in the fuzzy precedence network to find the critical path. The method presented in this paper is very effective in determining the critical activities and finding the critical paths.

  11. Modified Homotopy Analysis Method for Zakharov-Kuznetsov Equations

    Directory of Open Access Journals (Sweden)

    Muhammad USMAN

    2013-01-01

    Full Text Available In this paper, we apply Modified Homotopy Analysis Method (MHAM to find appropriate solutions of Zakharov-Kuznetsov equations which are of utmost importance in applied and engineering sciences. The proposed modification is the elegant coupling of Homotopy Analysis Method (HAM and Taylor’s series. Numerical results coupled with graphical representation explicitly reveal the complete reliability of the proposed algorithm.

  12. 7 CFR 58.812 - Methods of sample analysis.

    Science.gov (United States)

    2010-01-01

    ... Marketing Service, Dairy Programs, or the Official Methods of Analysis of the Association of Official... 7 Agriculture 3 2010-01-01 2010-01-01 false Methods of sample analysis. 58.812 Section 58.812 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE...

  13. Validation of a hybrid life-cycle inventory analysis method.

    Science.gov (United States)

    Crawford, Robert H

    2008-08-01

    The life-cycle inventory analysis step of a life-cycle assessment (LCA) may currently suffer from several limitations, mainly concerned with the use of incomplete and unreliable data sources and methods of assessment. Many past LCA studies have used traditional inventory analysis methods, namely process analysis and input-output analysis. More recently, hybrid inventory analysis methods have been developed, combining these two traditional methods in an attempt to minimise their limitations. In light of recent improvements, these hybrid methods need to be compared and validated, as these too have been considered to have several limitations. This paper evaluates a recently developed hybrid inventory analysis method which aims to improve the limitations of previous methods. It was found that the truncation associated with process analysis can be up to 87%, reflecting the considerable shortcomings in the quantity of process data currently available. Capital inputs were found to account for up to 22% of the total inputs to a particular product. These findings suggest that current best-practice methods are sufficiently accurate for most typical applications, but this is heavily dependent upon data quality and availability. The use of input-output data assists in improving the system boundary completeness of life-cycle inventories. However, the use of input-output analysis alone does not always provide an accurate model for replacing process data. Further improvements in the quantity of process data currently available are needed to increase the reliability of life-cycle inventories.

  14. A Practical Method of Policy Analysis by Simulating Policy Options

    Science.gov (United States)

    Phelps, James L.

    2011-01-01

    This article focuses on a method of policy analysis that has evolved from the previous articles in this issue. The first section, "Toward a Theory of Educational Production," identifies concepts from science and achievement production to be incorporated into this policy analysis method. Building on Kuhn's (1970) discussion regarding paradigms, the…

  15. A novel method for production of activated carbon from waste tea by chemical activation with microwave energy

    Energy Technology Data Exchange (ETDEWEB)

    Emine Yagmur; Meryem Ozmak; Zeki Aktas [Ankara University, Ankara (Turkey). Faculty of Engineering

    2008-11-15

    This study presents the production of activated carbon from waste tea. Activated carbons were prepared by phosphoric acid activation with and without microwave treatment and carbonisation of the waste tea under nitrogen atmosphere at various temperatures and different phosphoric acid/precursor impregnation ratios. The surface properties of the activated carbons were investigated by elemental analysis, BET surface area, SEM, FTIR. Prior to heat treatment conducted in a furnace, the mixture of the waste tea and H{sub 3}PO{sub 4} was treated with microwave heating. The maximum BET surface area was 1157 m{sup 2}/g for the sample treated with microwave energy and then carbonised at 350{sup o}C. In case of application of conventional method, the BET surface area of the resultant material was 928.8 m{sup 2}/g using the same precursor and conditions. According to the Dubinin-Radushkevich (DR) method the micropore surface area for the sample treated with microwave energy was higher than the sample obtained from the conventional method. Results show that microwave heating reasonably influenced the micropore surface area of the samples as well as the BET surface area. The samples activated were also characterised in terms of the cumulative pore and micropore volumes according to the BJH, DR and t-methods, respectively. 35 refs., 6 figs., 4 tabs.

  16. Comparison The Effects of Two Monocyte Isolation Methods,Plastic Adherence and Magnetic Activated Cell Sorting Methods,on Phagocytic Activity of Generated Dendritic Cells

    Directory of Open Access Journals (Sweden)

    Behnaz Asadi

    2013-01-01

    Full Text Available Objective: It is believed that monocyte isolation methods and maturation factors affect the phenotypic and functional characteristics of resultant dendritic cells (DC. In the present study, we compared two monocyte isolation methods, including plastic adherence-dendritic cells (Adh-DC and magnetic activated cell sorting- dendritic cells (MACS-DC, and their effects on phagocytic activity of differentiated immature DCs (immDCs.Materials and Methods: In this experimental study, immDCs were generated from plastic adherence and MACS isolated monocytes in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF and interleukin 4 (IL-4 in five days. The phagocytic activity of immDCs was analyzed by fluorescein isothiocyanate (FITC-conjugated latex bead using flow cytometry. One way ANOVA test was used for statistical analysis of differences among experimental groups, including Adh-DC and MACS-DC groups.Results: We found that phagocytic activity of Adh-DC was higher than MACS-DC, whereas the mean fluorescence intensity (MFI of phagocytic cells was higher in MACS-DC (p<0.05.Conclusion: We concluded that it would be important to consider phagocytosis parameters of generated DCs before making any decision about monocyte isolation methods to have fully functional DCs.

  17. RESULTS OF THE QUESTIONNAIRE: ANALYSIS METHODS

    CERN Multimedia

    Staff Association

    2014-01-01

    Five-yearly review of employment conditions   Article S V 1.02 of our Staff Rules states that the CERN “Council shall periodically review and determine the financial and social conditions of the members of the personnel. These periodic reviews shall consist of a five-yearly general review of financial and social conditions;” […] “following methods […] specified in § I of Annex A 1”. Then, turning to the relevant part in Annex A 1, we read that “The purpose of the five-yearly review is to ensure that the financial and social conditions offered by the Organization allow it to recruit and retain the staff members required for the execution of its mission from all its Member States. […] these staff members must be of the highest competence and integrity.” And for the menu of such a review we have: “The five-yearly review must include basic salaries and may include any other financial or soc...

  18. Complex system analysis using CI methods

    Science.gov (United States)

    Fathi, Madjid; Hildebrand, Lars

    1999-03-01

    Modern technical tasks often need the use of complex system models. In many complex cases the model parameters can be gained using neural networks, but these systems allow only a one-way simulation from the input values to the learned output values. If evaluation in the other direction is needed, these model allow no direct evaluation. This task can be solved using evolutionary algorithms, which are part of the computational intelligence. The term computational intelligence covers three special fields of the artificial intelligence, fuzzy logic, artificial neural networks and evolutionary algorithms. We will focus only on the topic of evolutionary algorithms and fuzzy logic. Evolutionary algorithms covers the fields of genetic algorithms, evolution strategies and evolutionary programming. These methods can be used to optimize technical problems. Evolutionary algorithms have certain advantages, if these problems have no mathematical properties, like steadiness or the possibility to obtain the derivatives. Fuzzy logic systems normally lack these properties. The use of a combination of evolutionary algorithms and fuzzy logic allow an evaluation of the learned simulation models in the direction form output to the input values. An example can be given from the field of screw rotor design.

  19. Immunofluorescence in cytogenetic analysis: method and applications

    Directory of Open Access Journals (Sweden)

    Jeppesen Peter

    2000-01-01

    Full Text Available Control of the genetic information encoded by DNA in mammalian chromosomes is mediated by proteins, some of which are only transiently attached, although others are intrinsically associated with nucleic acid in the complex mixture known as chromatin. Chromatin-associated proteins range from the ubiquitous and abundant histones down to the most specific and rare of transcription factors. Although many chromatin proteins are probably excluded from highly condensed mitotic chromosomes, a number are retained throughout the cell cycle and can be detected on chromosomes in metaphase spreads. Comparing the distribution of a chromosomal protein with known cytogenetic markers on metaphase chromosomes can provide an important and potentially highly informative first source of data on the function of the protein under consideration. The aim of the present study is to summarize some of the principles involved in obtaining suitable chromosome preparations for subsequent immunolocalization of protein antigens. Some applications of the method will be included to illustrate how this approach has increased our understanding of chromosome structure and genetic regulation.

  20. Some Applications of Fast Neutron Activation Analysis of Oxygen

    Energy Technology Data Exchange (ETDEWEB)

    Owrang, Farshid

    2003-07-01

    illustrated how the activated water would propagate along that pipe. C) Combustion products. In order to investigate the oxidation in combustion products (deposits), the total amount of oxygen in the deposits collected from combustion chambers of a modern gasoline engine was measured, using cyclic fast neutron activation analysis (FNAA). As a compartment, the organic compounds containing oxygen were identified using {sup 13}C solid-state nuclear magnetic resonance (NMR) spectroscopy. The results of FNAA showed that the amount of oxygen in deposits varies depending on where the deposits have been formed. {sup 13}C NMR has showed that the carbon backbone of the deposits exists as highly oxidized poly aromatics and/or graphitic structure. D) On-line fast neutron activation analysis. On-line neutron activation analysis was used to detect the amount of oxygen in bulk liquids. The method was optimised for on-line detection of oxygen in rapeseed oil. The goal was to develop a non-intrusive method for measurement of the total amount of oxygen in oil during combustion/oxidation.

  1. Dictionary learning and sparse recovery for electrodermal activity analysis

    Science.gov (United States)

    Kelsey, Malia; Dallal, Ahmed; Eldeeb, Safaa; Akcakaya, Murat; Kleckner, Ian; Gerard, Christophe; Quigley, Karen S.; Goodwin, Matthew S.

    2016-05-01

    Measures of electrodermal activity (EDA) have advanced research in a wide variety of areas including psychophysiology; however, the majority of this research is typically undertaken in laboratory settings. To extend the ecological validity of laboratory assessments, researchers are taking advantage of advances in wireless biosensors to gather EDA data in ambulatory settings, such as in school classrooms. While measuring EDA in naturalistic contexts may enhance ecological validity, it also introduces analytical challenges that current techniques cannot address. One limitation is the limited efficiency and automation of analysis techniques. Many groups either analyze their data by hand, reviewing each individual record, or use computationally inefficient software that limits timely analysis of large data sets. To address this limitation, we developed a method to accurately and automatically identify SCRs using curve fitting methods. Curve fitting has been shown to improve the accuracy of SCR amplitude and location estimations, but have not yet been used to reduce computational complexity. In this paper, sparse recovery and dictionary learning methods are combined to improve computational efficiency of analysis and decrease run time, while maintaining a high degree of accuracy in detecting SCRs. Here, a dictionary is first created using curve fitting methods for a standard SCR shape. Then, orthogonal matching pursuit (OMP) is used to detect SCRs within a dataset using the dictionary to complete sparse recovery. Evaluation of our method, including a comparison to for speed and accuracy with existing software, showed an accuracy of 80% and a reduced run time.

  2. Schedulability Analysis Method of Timing Constraint Petri Nets

    Institute of Scientific and Technical Information of China (English)

    李慧芳; 范玉顺

    2002-01-01

    Timing constraint Petri nets (TCPNs) can be used to model a real-time system specification and to verify the timing behavior of the system. This paper describes the limitations of the reachability analysis method in analyzing complex systems for existing TCPNs. Based on further research on the schedulability analysis method with various topology structures, a more general state reachability analysis method is proposed. To meet various requirements of timely response for actual systems, this paper puts forward a heuristic method for selecting decision-spans of transitions and develops a heuristic algorithm for schedulability analysis of TCPNs. Examples are given showing the practicality of the method in the schedulability analysis for real-time systems with various structures.

  3. Analysis of foreign physical activity recommendations and guidelines for schools

    Directory of Open Access Journals (Sweden)

    Jan Pavelka

    2014-06-01

    Full Text Available Background:An adequate level of physical activity is an important part of children's lifestyle. The school environment plays a significant role in the area of interventions and strategies aiming to increase the level of physical activity in children. Objectives: The aim of this study is to analyse foreign recommendations leading to an increased level of physical activity in children and young people in Czech schools. Methods: A systematic search of studies published between 1988 and 2012 in the English language was completed in library databases Medline, Sport Discus, ProQuest, PsychInfo, ERIC, Wiley InterScience using the following keywords: physical activity, guidelines, recommendations, school and youth. The studies were then classified based on abstract and full-text analyses. Using a content analysis the expert team formulated the final recommendations to increase the level of physical activity for schools in the Czech Republic (CR. Results: Out of the total number of 91 identified foreign studies, 25 met the predetermined criteria and were used as a basis for formulating the recommendations. These foreign studies included 15 papers published in USA, two in Australia, two in Great Britain, two in Canada, one in the European Union, one in New Zealand and one international paper (an international consensus of experts from 34 countries. Based on the interpretation of the evidence, its justification and final consensus of the expert team, the basic areas for the recommendations to increase the level of physical activity in schools in the CR were identified. Conclusions: An analysis of foreign recommendations to increase the level of physical activity designed for schools and school facilities is one of the possible methods of formulating domestic recommendations. This recommendation could contribute to deeper understanding of the issue of the deteriorating lifestyle of school-aged children in the CR and reflects the efforts for improvement.

  4. 活化法测量中子活化在线分析系统样品处的中子能谱%Neutron Spectrum Measurement with Activation Method in Sample Place of On-line Neutron Activation Analysis System

    Institute of Scientific and Technical Information of China (English)

    王松林; 孔祥忠; 邓勇军; 拓飞; 王琦; 位金锋; 李永明

    2009-01-01

    用多箔活化法测定了由Am-Be中子源慢化屏蔽系统构成的中子活化在线分析系统样品处的中子能谱.根据待测场点的中子注量率水平,选用了5种非裂变核材料箔,其中4种是中能区和热区的,1种是快区的,给出了各箔片的特性参数.通过在待测场点对箔片进行辐照,并测量其生成放射性核的γ放射性,计算出了各箔片的活化率.运用SAND-II和MSIT迭代方法,解出了待测场点的中子能谱.详细分析了数据处理过程中群截面的加工处理以及由于自屏蔽效应引起的群截面修正问题;研究了影响解谱精度的主要因素;对解谱结果作了一定的分析讨论;并用蒙特卡罗(MC)方法对最后的中子能谱做了不确定度分析.%The neutron spectrum in sample place of on-line neutron activation analysis system was measured with multiple foil activation technique. According to the neutron fluence level of measuring request, 5 kinds of non-fission nuclear material foils were selected, of which 4 were sensitive to thermal energy region and intermediate energy region, and 1 was sensitive to fast energy region. By measuring the foil activity, the neutron spectrum that was needed to measured was unfolded with the iterative methods SAND-II and MSIT. Meanwhile, the process of producing and modifying group cross section were analysed amply. The main factors which have influence on the accuracy of the solution were studied. The discussion for solution was done simply, and the uncertainty of solution was analysed by using the Monte Carlo method.

  5. Rotordynamic Analysis with Shell Elements for the Transfer Matrix Method

    Science.gov (United States)

    1989-08-01

    jACCESSION NO. 11. TITLE (Include Security Classification) (UNCLASSIFIED) ROTORDYNAMIC ANALYSIS WITH SHELL ELEMENTS FOR THE TRANSFER MATRIX METHOD 12...SECURITY CLASSIFICATION OF THIS PAGE AFIT/CI "OVERPRINT" iii ABSTRACT Rotordynamic Analysis with Shell Elements for the Transfer Matrix Method. (August...analysts in indus- try . ’ . ," Accesiu:, For NTIS CR,4i Fi FilC TA,: [3 0. fi A-1 B I ., ,.................. ,., ROTORDYNAMIC ANALYSIS WITH SHELL ELEMENTS

  6. Effect of biochar activation by different methods on toxicity of soil contaminated by industrial activity.

    Science.gov (United States)

    Kołtowski, Michał; Charmas, Barbara; Skubiszewska-Zięba, Jadwiga; Oleszczuk, Patryk

    2017-02-01

    The objective of the study was to determine the effect of various methods of biochar activation on the ecotoxicity of soils with various properties and with various content and origin of contaminants. The biochar produced from willow (at 700°C) was activated by 1) microwaves (in a microwave reactor under an atmosphere of water vapour), 2) carbon dioxide (in the quartz fluidized bed reactor) and 3) superheated steam (in the quartz fluidized bed reactor). Three different soils were collected from industrial areas. The soils were mixed with biochar and activated biochars at the dose of 5% and ecotoxicological parameters of mixture was evaluated using two solid phase test - Phytotoxkit F (Lepidium sativum) and Collembolan test (Folsomia candida) and one liquid phase test - Microtox® (Vibrio fischeri). Biochar activation had both positive and negative impacts, depending on the activation method, kind of bioassay and kind of soil. Generally, biochar activated by microwaves increased the effectiveness of ecotoxicity reduction relative to non-activated biochars. Whereas, biochar activated with CO2 most often cause a negative effect manifested by deterioration or as a lack of improvement in relation to non-activated biochar or to non-amended soil. It was also demonstrated that the increase of biochar specific surface area caused a significant reduction of toxicity of water leachates from the studied soils. Effectiveness of the reduction of leachate toxicity was weakened in the presence of dissolved organic carbon in the soil. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Network analysis of online bidding activity

    Science.gov (United States)

    Yang, I.; Oh, E.; Kahng, B.

    2006-07-01

    With the advent of digital media, people are increasingly resorting to online channels for commercial transactions. The online auction is a prototypical example. In such online transactions, the pattern of bidding activity is more complex than traditional offline transactions; this is because the number of bidders participating in a given transaction is not bounded and the bidders can also easily respond to the bidding instantaneously. By using the recently developed network theory, we study the interaction patterns between bidders (items) who (that) are connected when they bid for the same item (if the item is bid by the same bidder). The resulting network is analyzed by using the hierarchical clustering algorithm, which is used for clustering analysis for expression data from DNA microarrays. A dendrogram is constructed for the item subcategories; this dendrogram is compared to a traditional classification scheme. The implication of the difference between the two is discussed.

  8. Method for detecting software anomalies based on recurrence plot analysis

    OpenAIRE

    Michał Mosdorf

    2012-01-01

    Presented paper evaluates method for detecting software anomalies based on recurrence plot analysis of trace log generated by software execution. Described method for detecting software anomalies is based on windowed recurrence quantification analysis for selected measures (e.g. Recurrence rate - RR or Determinism - DET). Initial results show that proposed method is useful in detecting silent software anomalies that do not result in typical crashes (e.g. exceptions).

  9. Method for detecting software anomalies based on recurrence plot analysis

    Directory of Open Access Journals (Sweden)

    Michał Mosdorf

    2012-03-01

    Full Text Available Presented paper evaluates method for detecting software anomalies based on recurrence plot analysis of trace log generated by software execution. Described method for detecting software anomalies is based on windowed recurrence quantification analysis for selected measures (e.g. Recurrence rate - RR or Determinism - DET. Initial results show that proposed method is useful in detecting silent software anomalies that do not result in typical crashes (e.g. exceptions.

  10. Multifractal detrended fluctuation analysis of optogenetic modulation of neural activity

    Science.gov (United States)

    Kumar, S.; Gu, L.; Ghosh, N.; Mohanty, S. K.

    2013-02-01

    Here, we introduce a computational procedure to examine whether optogenetically activated neuronal firing recordings could be characterized as multifractal series. Optogenetics is emerging as a valuable experimental tool and a promising approach for studying a variety of neurological disorders in animal models. The spiking patterns from cortical region of the brain of optogenetically-stimulated transgenic mice were analyzed using a sophisticated fluctuation analysis method known as multifractal detrended fluctuation analysis (MFDFA). We observed that the optogenetically-stimulated neural firings are consistent with a multifractal process. Further, we used MFDFA to monitor the effect of chemically induced pain (formalin injection) and optogenetic treatment used to relieve the pain. In this case, dramatic changes in parameters characterizing a multifractal series were observed. Both the generalized Hurst exponent and width of singularity spectrum effectively differentiates the neural activities during control and pain induction phases. The quantitative nature of the analysis equips us with better measures to quantify pain. Further, it provided a measure for effectiveness of the optogenetic stimulation in inhibiting pain. MFDFA-analysis of spiking data from other deep regions of the brain also turned out to be multifractal in nature, with subtle differences in the parameters during pain-induction by formalin injection and inhibition by optogenetic stimulation. Characterization of neuronal firing patterns using MFDFA will lead to better understanding of neuronal response to optogenetic activation and overall circuitry involved in the process.

  11. Behavioural activation for depression; an update of meta-analysis of effectiveness and sub group analysis.

    Directory of Open Access Journals (Sweden)

    David Ekers

    Full Text Available BACKGROUND: Depression is a common, disabling condition for which psychological treatments are recommended. Behavioural activation has attracted increased interest in recent years. It has been over 5 years since our meta-analyses summarised the evidence supporting and this systematic review updates those findings and examines moderators of treatment effect. METHOD: Randomised trials of behavioural activation for depression versus controls or anti-depressant medication were identified using electronic database searches, previous reviews and reference lists. Data on symptom level and study level moderators were extracted and analysed using meta-analysis, sub-group analysis and meta-regression respectively. RESULTS: Twenty six randomised controlled trials including 1524 subjects were included in this meta-analysis. A random effects meta-analysis of symptom level post treatment showed behavioural activation to be superior to controls (SMD -0.74 CI -0.91 to -0.56, k = 25, N = 1088 and medication (SMD -0.42 CI -0.83 to-0.00, k = 4, N = 283. Study quality was low in the majority of studies and follow- up time periods short. There was no indication of publication bias and subgroup analysis showed limited association between moderators and effect size. CONCLUSIONS: The results in this meta-analysis support and strengthen the evidence base indicating Behavioural Activation is an effective treatment for depression. Further high quality research with longer term follow-up is needed to strengthen the evidence base.

  12. Optimal Recognition Method of Human Activities Using Artificial Neural Networks

    Directory of Open Access Journals (Sweden)

    Oniga Stefan

    2015-12-01

    Full Text Available The aim of this research is an exhaustive analysis of the various factors that may influence the recognition rate of the human activity using wearable sensors data. We made a total of 1674 simulations on a publically released human activity database by a group of researcher from the University of California at Berkeley. In a previous research, we analyzed the influence of the number of sensors and their placement. In the present research we have examined the influence of the number of sensor nodes, the type of sensor node, preprocessing algorithms, type of classifier and its parameters. The final purpose is to find the optimal setup for best recognition rates with lowest hardware and software costs.

  13. Expectations of Formal Model Analysis Methods: Implications for SIG-MA

    NARCIS (Netherlands)

    Slinger, J.H.

    2009-01-01

    At the 2008 System Dynamics Conference in Athens a survey of the understanding and expectations of conference participants regarding model analysis was conducted. Respondents included both those active in research on formal model analysis methods and those only vaguely familiar with the term. Result

  14. Analysis of physical activities in Taekwondo Pumsae.

    Science.gov (United States)

    Lee, Sang-Bock; Cha, Eun-Jong; Lee, Tae-Soo

    2008-01-01

    Exercise is very important element for successful aging. Among many sports events, Korea is the suzerain of Taekwondo. When competing (Taekwondo Free Fighting) after learning Poomse as basic movements and inuring them, people compete with movements depending on situation. Among Poomses of Taekwondo, Taegeuk Poomse consists of very basic movements from 1 Jang to 8 Jang and they are for inuring to body. In order to prescribe Taegeuk Jang, which is the basic movement of Taekwondo that Korea is the suzerain, as an exercise for successful aging, it is necessary to analyze physical activity level of each Taegeuk Jang (From 1 Jang through 8 Jang) and suggest the same. Therefore, in this study, I analyzed physical activity level of each Jang of Taegeuk Poomse by attaching Armband made by Body Media Company on brachia and legs below knee of Taekwondo trainees. The result of the analysis of the whole momentum from Taegeuk 1 Jang to 8 Jang is as follows: First, the average absolute value of acceleration variation of vertical direction signal (L-MAD): 5.15. Second, the average absolute value of acceleration variation of horizontal direction signal (T-MAD): 3.44. Finally, the average of calorie consumption per minute (AEE/Min): 5.06 Cal. The obtained result corresponds to proper exercise condition for successful aging and it can be utilized as data for exercise prescription for the young and the old.

  15. Stability and Accuracy Analysis for Taylor Series Numerical Method

    Institute of Scientific and Technical Information of China (English)

    赵丽滨; 姚振汉; 王寿梅

    2004-01-01

    The Taylor series numerical method (TSNM) is a time integration method for solving problems in structural dynamics. In this paper, a detailed analysis of the stability behavior and accuracy characteristics of this method is given. It is proven by a spectral decomposition method that TSNM is conditionally stable and belongs to the category of explicit time integration methods. By a similar analysis, the characteristic indicators of time integration methods, the percentage period elongation and the amplitude decay of TSNM, are derived in a closed form. The analysis plays an important role in implementing a procedure for automatic searching and finding convergence radii of TSNM. Finally, a linear single degree of freedom undamped system is analyzed to test the properties of the method.

  16. Stochastic Plane Stress Analysis with Elementary Stiffness Matrix Decomposition Method

    Science.gov (United States)

    Er, G. K.; Wang, M. C.; Iu, V. P.; Kou, K. P.

    2010-05-01

    In this study, the efficient analytical method named elementary stiffness matrix decomposition (ESMD) method is further investigated and utilized for the moment evaluation of stochastic plane stress problems in comparison with the conventional perturbation method in stochastic finite element analysis. In order to evaluate the performance of this method, computer programs are written and some numerical results about stochastic plane stress problems are obtained. The numerical analysis shows that the computational efficiency is much increased and the computer EMS memory requirement can be much reduced by using ESMD method.

  17. A Rapid Method for Measuring Strontium-90 Activity in Crops in China

    Science.gov (United States)

    Pan, Lingjing Pan; Yu, Guobing; Wen, Deyun; Chen, Zhi; Sheng, Liusi; Liu, Chung-King; Xu, X. George

    2017-09-01

    A rapid method for measuring Sr-90 activity in crop ashes is presented. Liquid scintillation counting, combined with ion exchange columns 4`, 4"(5")-di-t-butylcyclohexane-18-crown-6, is used to determine the activity of Sr-90 in crops. The yields of chemical procedure are quantified using gravimetric analysis. The conventional method that uses ion-exchange resin with HDEHP could not completely remove all the bismuth when comparatively large lead and bismuth exist in the samples. This is overcome by the rapid method. The chemical yield of this method is about 60% and the MDA for Sr-90 is found to be 2:32 Bq/kg. The whole procedure together with using spectrum analysis to determine the activity only takes about one day, which is really a large improvement compared with the conventional method. A modified conventional method is also described here to verify the value of the rapid one. These two methods can meet di_erent needs of daily monitoring and emergency situation.

  18. A gasometric method to determine erythrocyte catalase activity

    Directory of Open Access Journals (Sweden)

    A.J.S. Siqueira

    1999-09-01

    Full Text Available We describe a new gasometric method to determine erythrocyte catalase activity by the measurement of the volume of oxygen produced as a result of hydrogen peroxide decomposition in a system where enzyme and substrate are separated in a special reaction test tube connected to a manometer and the reagents are mixed with a motor-driven stirrer. The position of the reagents in the test tube permits the continuous measurement of oxygen evolution from the time of mixing, without the need to stop the reaction by the addition of acid after each incubation time. The enzyme activity is reported as KHb, i.e., mg hydrogen peroxide decomposed per second per gram of hemoglobin (s-1 g Hb-1. The value obtained for catalase activity in 28 samples of hemolyzed human blood was 94.4 ± 6.17 mg H2O2 s-1 g Hb-1. The results obtained were precise and consistent, indicating that this rapid, simple and inexpensive method could be useful for research and routine work.

  19. WORK ANALYSIS IN ORGANIZATIONS – DEFINITION, USES AND METHODS

    Directory of Open Access Journals (Sweden)

    Andrea Valéria Steil

    2016-11-01

    Full Text Available Work analysis is a process used to understand what the important tasks of the job are, how they are performed, and what human attributes are necessary to carry them out successfully. Work analysis is an attempt to develop a theory of human behavior about the job in question to support management decisions. This paper defines work analysis, discusses its main uses in organizations, and presents the objects of study and the methods of work analysis. This paper also discusses how work analysis is done, considering the following steps:  types of data to be collected, data sources, data collecting methods, summary of the information and work analysis reports. This paper ends with the differentiation of work analysis and individual modeling skills and brings arguments to endorse work analysis as an intervention of work and organizational psychology.

  20. Research on the Analysis Method of Micro Concentration of Uranium

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Spectrophotometric method is used for the analysis of micro concentration of uraninum in aqueousand organic phase in order to test the feasibility of TBP/OK-dimethylbenzene-TTA method for assayingorganic phase and concentrated hydrochloric acid-arsenazo Ⅲ method for assaying aqueous phase. It is

  1. 21 CFR 2.19 - Methods of analysis.

    Science.gov (United States)

    2010-04-01

    ... enforcement programs to utilize the methods of analysis of the AOAC INTERNATIONAL (AOAC) as published in the... reference, when available and applicable. Copies are available from the AOAC INTERNATIONAL, 481 North... AOAC method, the Commissioner will furnish a copy of the particular method, or a reference to the...

  2. Reliability analysis method applied in slope stability: slope prediction and forecast on stability analysis

    Institute of Scientific and Technical Information of China (English)

    Wenjuan ZHANG; Li CHEN; Ning QU; Hai'an LIANG

    2006-01-01

    Landslide is one kind of geologic hazards that often happens all over the world. It brings huge losses to human life and property; therefore, it is very important to research it. This study focused in combination between single and regional landslide, traditional slope stability analysis method and reliability analysis method. Meanwhile, methods of prediction of slopes and reliability analysis were discussed.

  3. A general method for determining secondary active transporter substrate stoichiometry

    Science.gov (United States)

    Fitzgerald, Gabriel A; Mulligan, Christopher; Mindell, Joseph A

    2017-01-01

    The number of ions required to drive substrate transport through a secondary active transporter determines the protein’s ability to create a substrate gradient, a feature essential to its physiological function, and places fundamental constraints on the transporter’s mechanism. Stoichiometry is known for a wide array of mammalian transporters, but, due to a lack of readily available tools, not for most of the prokaryotic transporters for which high-resolution structures are available. Here, we describe a general method for using radiolabeled substrate flux assays to determine coupling stoichiometries of electrogenic secondary active transporters reconstituted in proteoliposomes by measuring transporter equilibrium potentials. We demonstrate the utility of this method by determining the coupling stoichiometry of VcINDY, a bacterial Na+-coupled succinate transporter, and further validate it by confirming the coupling stoichiometry of vSGLT, a bacterial sugar transporter. This robust thermodynamic method should be especially useful in probing the mechanisms of transporters with available structures. DOI: http://dx.doi.org/10.7554/eLife.21016.001 PMID:28121290

  4. Alternative method for quantification of alfa-amylase activity

    Directory of Open Access Journals (Sweden)

    DF. Farias

    Full Text Available A modification of the sensitive agar diffusion method was developed for macro-scale determination of alfa-amylase. The proposed modifications lower costs with the utilisation of starch as substrate and agar as supporting medium. Thus, a standard curve was built using alfa-amylase solution from Aspergillus oryzae, with concentrations ranging from 2.4 to 7,500 U.mL-1. Clear radial diffusion zones were measured after 4 hours of incubation at 20 °C. A linear relationship between the logarithm of enzyme activities and the area of clear zones was obtained. The method was validated by testing α-amylase from barley at the concentrations of 2.4; 60; 300 and 1,500 U.mL-1. The proposed method turned out to be simpler, faster, less expensive and able to determine on a macro-scale α-amylase over a wide range (2.4 to 7,500 U.mL-1 in scientific investigation as well as in teaching laboratory activities.

  5. Piezoelectric Analysis of Saw Sensor Using Finite Element Method

    OpenAIRE

    Vladimír KUTIŠ; Gabriel GÁLIK; Ivan RÝGER; Murín, Justín; Juraj HRABOVSKÝ; Juraj PAULECH; Tibor LALINSKÝ

    2013-01-01

    In this contribution modeling and simulation of surface acoustic waves (SAW) sensor using finite element method will be presented. SAW sensor is made from piezoelectric GaN layer and SiC substrate. Two different analysis types are investigated - modal and transient. Both analyses are only 2D. The goal of modal analysis, is to determine the eigenfrequency of SAW, which is used in following transient analysis. In transient analysis, wave propagation in SAW sensor is investigated. Both analyses ...

  6. Structure-activity study of thiazides by magnetic resonance methods (NQR, NMR, EPR) and DFT calculations.

    Science.gov (United States)

    Latosińska, J N

    2005-01-01

    The paper presents a comprehensive analysis of the relationship between the electronic structure of thiazides and their biological activity. The compounds of interest were studied in solid state by the resonance methods nuclear quadrupole resonance (NQR), nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) and quantum chemistry (ab inito and DFT) methods. Detailed parallel analysis of the spectroscopic parameters such as quadrupole coupling constant (QCC) NQR chemical shift (delta), chemical shift anisotropy (CSA), asymmetry parameter (eta), NMR and hyperfine coupling constant (A), EPR was performed and the electronic effects (polarisation and delocalisation) were revealed and compared. Biological activity of thiazides has been found to depend on many factors, but mainly on the physico-chemical properties whose assessment was possible on the basis of electron density determination in the molecules performed by experimental and theoretical methods.

  7. Validation of an activity optimization method for nuclear medicine in planar studies

    Energy Technology Data Exchange (ETDEWEB)

    Perez D, M. [Central University of Las Villas, CEETI, Camajuani Road Km 5.5, Santa Clara 54830 Villa Clara (Cuba); Diaz R, O. [Institute for Sciences and Advanced Technologies (Cuba); Farias L, F. [Federal University of Pernambuco (Brazil)]. e-mail: mperez@uclv.edu.cu

    2006-07-01

    A method for optimizing the administered activity in Static Nuclear Medicine Studies is validated by comparison with ROC curve. Linear Discriminant analysis of image quality in gamma cameras was the applied statistical technique. The constructed linear discriminant function owns as dependent parameters, the differentiated levels of image quality obtained by observer's criterion. The independent parameters in the function were physical variables, as Signal-to Background ratios and Signal-to-Noise ratios. They were obtained from the selection of Regions of Interest in images obtained from a Jaszczak phantom, corresponding to lesion and background sites. The percentage of cases correctly classified by discriminant analysis was analyzed to grade the proposed discriminant method. The minimum value of the administered activity, which permits good image quality, (it means good results for the parameters selected by the discriminant function), can be proposed as an optimized value of activity for planar studies of Nuclear Medicine. The method was tested using images from a Jaszczak phantom, acquired under four activities (1088 MBq, 962 MBq, 740 MBq and 562 MBq) with a gamma camera equipped with a high resolution - low energy- parallel-hole collimator. The gamma camera was tested by a NEMA protocol. Image quality was graded by three expert observers who also developed a rated procedure which consist in analyzing the images for ROC analysis. Two of the six measured Background-to-Signal ratios were the parameters able to construct the linear discriminant function with high correlation respect to the observer criterion, from all the measured physical variables. The value of 740 MBq was the optimum after discriminant method application in this particular experiment. The results were coincident with the application of ROC-analysis. The optimal activity value obtained with the proposed discriminant procedure coincided with the activity value for which the area under the ROC

  8. Mathematical analysis of complex cellular activity

    CERN Document Server

    Bertram, Richard; Teka, Wondimu; Vo, Theodore; Wechselberger, Martin; Kirk, Vivien; Sneyd, James

    2015-01-01

    This book contains two review articles on mathematical physiology that deal with closely related topics but were written and can be read independently. The first article reviews the basic theory of calcium oscillations (common to almost all cell types), including spatio-temporal behaviors such as waves. The second article uses, and expands on, much of this basic theory to show how the interaction of cytosolic calcium oscillators with membrane ion channels can result in highly complex patterns of electrical spiking. Through these examples one can see clearly how multiple oscillatory processes interact within a cell, and how mathematical methods can be used to understand such interactions better. The two reviews provide excellent examples of how mathematics and physiology can learn from each other, and work jointly towards a better understanding of complex cellular processes. Review 1: Richard Bertram, Joel Tabak, Wondimu Teka, Theodore Vo, Martin Wechselberger: Geometric Singular Perturbation Analysis of Burst...

  9. Eye movement analysis for activity recognition using electrooculography.

    Science.gov (United States)

    Bulling, Andreas; Ward, Jamie A; Gellersen, Hans; Tröster, Gerhard

    2011-04-01

    In this work, we investigate eye movement analysis as a new sensing modality for activity recognition. Eye movement data were recorded using an electrooculography (EOG) system. We first describe and evaluate algorithms for detecting three eye movement characteristics from EOG signals-saccades, fixations, and blinks-and propose a method for assessing repetitive patterns of eye movements. We then devise 90 different features based on these characteristics and select a subset of them using minimum redundancy maximum relevance (mRMR) feature selection. We validate the method using an eight participant study in an office environment using an example set of five activity classes: copying a text, reading a printed paper, taking handwritten notes, watching a video, and browsing the Web. We also include periods with no specific activity (the NULL class). Using a support vector machine (SVM) classifier and person-independent (leave-one-person-out) training, we obtain an average precision of 76.1 percent and recall of 70.5 percent over all classes and participants. The work demonstrates the promise of eye-based activity recognition (EAR) and opens up discussion on the wider applicability of EAR to other activities that are difficult, or even impossible, to detect using common sensing modalities.

  10. Communication Systems and Study Method for Active Distribution Power systems

    DEFF Research Database (Denmark)

    Wei, Mu; Chen, Zhe

    Due to the involvement and evolvement of communication technologies in contemporary power systems, the applications of modern communication technologies in distribution power system are becoming increasingly important. In this paper, the International Organization for Standardization (ISO....... The suitability of the communication technology to the distribution power system with active renewable energy based generation units is discussed. Subsequently the typical possible communication systems are studied by simulation. In this paper, a novel method of integrating communication system impact into power...... system simulation is presented to address the problem of lack of off-shelf research tools on the power system communication. The communication system is configured and studied by the OPNET, and the performance of an active distribution power system integrated with the communication system is simulated...

  11. [Method of determining tissue renin activity using heterologous serum].

    Science.gov (United States)

    Orbetsova, V Ts; Kiprov, D

    1979-01-01

    The authors described a method for determination of tissue renin activity with heterologous substrate. The preparation of the substrate was performed at several stages: salting with amonium sulfate; dialisis of the precipitate till complete separation of amonium sulfate molecules; distruction of angiotensinases by interchangeble souring and alcalization of the medium; lyophylization of the pure substrate. The obtained renin-substrate was preserved in ampules and its usage had a series of advantages--duration, economic, a possibility for standartization of the determination, etc., which were described in details in the article. The described in details also the quantitative determination of the renin activity in the tissues (renal and cerebral) with the help of the obtained substrate as the moments, modiied by the authors, were indicated.

  12. Improved Methods for the Enrichment and Analysis of Glycated Peptides

    Science.gov (United States)

    Zhang, Qibin; Schepmoes, Athena A.; Brock, Jonathan W. C.; Wu, Si; Moore, Ronald J.; Purvine, Samuel O.; Baynes, John W.; Smith, Richard D.; Metz, Thomas O.

    2009-01-01

    Nonenzymatic glycation of tissue proteins has important implications in the development of complications of diabetes mellitus. Herein we report improved methods for the enrichment and analysis of glycated peptides using boronate affinity chromatography and electron-transfer dissociation mass spectrometry, respectively. The enrichment of glycated peptides was improved by replacing an off-line desalting step with an online wash of column-bound glycated peptides using 50 mM ammonium acetate, followed by elution with 100 mM acetic acid. The analysis of glycated peptides by MS/MS was improved by considering only higher charged (≥3) precursor ions during data-dependent acquisition, which increased the number of glycated peptide identifications. Similarly, the use of supplemental collisional activation after electron transfer (ETcaD) resulted in more glycated peptide identifications when the MS survey scan was acquired with enhanced resolution. Acquiring ETD-MS/MS data at a normal MS survey scan rate, in conjunction with the rejection of both 1+ and 2+ precursor ions, increased the number of identified glycated peptides relative to ETcaD or the enhanced MS survey scan rate. Finally, an evaluation of trypsin, Arg-C, and Lys-C showed that tryptic digestion of glycated proteins was comparable to digestion with Lys-C and that both were better than Arg-C in terms of the number of glycated peptides and corresponding glycated proteins identified by LC–MS/MS. PMID:18989935

  13. Improved Methods for the Enrichment and Analysis of Glycated Peptides

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Qibin; Schepmoes, Athena A; Brock, Jonathan W; Wu, Si; Moore, Ronald J; Purvine, Samuel O; Baynes, John; Smith, Richard D; Metz, Thomas O

    2008-12-15

    Non-enzymatic glycation of tissue proteins has important implications in the development of complications of diabetes mellitus. Herein we report improved methods for the enrichment and analysis of glycated peptides using boronate affinity chromatography and electron transfer dissociation mass spectrometry, respectively. The enrichment of glycated peptides was improved by replacing an off-line desalting step with an on-line wash of column-bound glycated peptides using 50 mM ammonium acetate. The analysis of glycated peptides by MS/MS was improved by considering only higher charged (≥3) precursor-ions during data-dependent acquisition, which increased the number of glycated peptide identifications. Similarly, the use of supplemental collisional activation after electron transfer (ETcaD) resulted in more glycated peptide identifications when the MS survey scan was acquired with enhanced resolution. In general, acquiring ETD-MS/MS data at a normal MS survey scan rate, in conjunction with the rejection of both 1+ and 2+ precursor-ions, increased the number of identified glycated peptides relative to ETcaD or the enhanced MS survey scan rate. Finally, an evaluation of trypsin, Arg-C, and Lys-C showed that tryptic digestion of glycated proteins was comparable to digestion with Lys-C and that both were better than Arg-C in terms of the number glycated peptides identified by LC-MS/MS.

  14. NONLINEAR DATA RECONCILIATION METHOD BASED ON KERNEL PRINCIPAL COMPONENT ANALYSIS

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    In the industrial process situation, principal component analysis (PCA) is a general method in data reconciliation.However, PCA sometime is unfeasible to nonlinear feature analysis and limited in application to nonlinear industrial process.Kernel PCA (KPCA) is extension of PCA and can be used for nonlinear feature analysis.A nonlinear data reconciliation method based on KPCA is proposed.The basic idea of this method is that firstly original data are mapped to high dimensional feature space by nonlinear function, and PCA is implemented in the feature space.Then nonlinear feature analysis is implemented and data are reconstructed by using the kernel.The data reconciliation method based on KPCA is applied to ternary distillation column.Simulation results show that this method can filter the noise in measurements of nonlinear process and reconciliated data can represent the true information of nonlinear process.

  15. Geothermal water and gas: collected methods for sampling and analysis. Comment issue. [Compilation of methods

    Energy Technology Data Exchange (ETDEWEB)

    Douglas, J.G.; Serne, R.J.; Shannon, D.W.; Woodruff, E.M.

    1976-08-01

    A collection of methods for sampling and analysis of geothermal fluids and gases is presented. Compilations of analytic options for constituents in water and gases are given. Also, a survey of published methods of laboratory water analysis is included. It is stated that no recommendation of the applicability of the methods to geothermal brines should be assumed since the intent of the table is to encourage and solicit comments and discussion leading to recommended analytical procedures for geothermal waters and research. (WHK)

  16. Antifungal activity of gold nanoparticles prepared by solvothermal method

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, Tokeer, E-mail: tahmad3@jmi.ac.in [Nanochemistry Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi 110025 (India); Wani, Irshad A.; Lone, Irfan H.; Ganguly, Aparna [Nanochemistry Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi 110025 (India); Manzoor, Nikhat; Ahmad, Aijaz [Department of Biosciences, Jamia Millia Islamia, New Delhi 110025 (India); Ahmed, Jahangeer [Department of Chemistry, Michigan State University, East Lansing, MI 48824 (United States); Al-Shihri, Ayed S. [Department of Chemistry, Faculty of Science, King Khalid University, Abha 61413, P.O. Box 9004 (Saudi Arabia)

    2013-01-15

    Graphical abstract: Gold nanoparticles (7 and 15 nm) of very high surface area (329 and 269 m{sup 2}/g) have been successfully synthesized through solvothermal method by using tin chloride and sodium borohydride as reducing agents. As-prepared gold nanoparticles shows very excellent antifungal activity against Candida isolates and activity increases with decrease in the particle size. Display Omitted Highlights: ► Effect of reducing agents on the morphology of gold nanoparticles. ► Highly uniform and monodisperse gold nanoparticles (7 nm). ► Highest surface area of gold nanoparticles (329 m{sup 2/}g). ► Excellent antifungal activity of gold nanoparticles against Candida strains. -- Abstract: Gold nanoparticles have been successfully synthesized by solvothermal method using SnCl{sub 2} and NaBH{sub 4} as reducing agents. X-ray diffraction studies show highly crystalline and monophasic nature of the gold nanoparticles with face centred cubic structure. The transmission electron microscopic studies show the formation of nearly spherical gold nanoparticles of average size of 15 nm using SnCl{sub 2}, however, NaBH{sub 4} produced highly uniform, monodispersed and spherical gold nanoparticles of average grain size of 7 nm. A high surface area of 329 m{sup 2}/g for 7 nm and 269 m{sup 2}/g for 15 nm gold nanoparticles was observed. UV–vis studies assert the excitations over the visible region due to transverse and longitudinal surface plasmon modes. The gold nanoparticles exhibit excellent size dependant antifungal activity and greater biocidal action against Candida isolates for 7 nm sized gold nanoparticles restricting the transmembrane H{sup +} efflux of the Candida species than 15 nm sized gold nanoparticles.

  17. Methodical Approach to Diagnostics of Efficiency of Production Economic Activity of an Enterprise

    Directory of Open Access Journals (Sweden)

    Zhukov Andrii V.

    2014-03-01

    Full Text Available The article offers developments of a methodical approach to diagnostics of efficiency of production economic activity of an enterprise, which, unlike the existing ones, is realised through the following stages: analysis of the enterprise external environment; analysis of the enterprise internal environment; identification of components of efficiency of production economic activity for carrying out complex diagnostics by the following directions: efficiency of subsystems of the enterprise production economic activity, efficiency of use of separate types of resources and socio-economic efficiency; scorecard formation; study of tendencies of change of indicators; identification of cause-effect dependencies between the main components of efficiency for diagnosing reasons of its level; diagnosing deviations of indicator values from their optimal values; development of a managerial decision on preserving and increasing efficiency of production economic activity of the enterprise.

  18. Analysis of uncertainties in a individualized method of estimation activity of {sup 1}31I for hyperthyroid patient; Analisis de incertidumbres en un metodo individualizado de estimacion de actividad de {sup 1}31I para el paciente hipertiroideo

    Energy Technology Data Exchange (ETDEWEB)

    Orellana Salas, A.; Melgar Perez, J.; Arrocha Acevedo, J. F.

    2013-07-01

    The determination of the activity to prescribe the hyperthyroid patients presented difficult consideration uncertainties. The uncertainties associated with the experimental design can exceed 20%, so it should be valued to customize activity therapy of {sup 1}31 I. (Author)

  19. Quantitative phosphoproteomic analysis using iTRAQ method.

    Science.gov (United States)

    Asano, Tomoya; Nishiuchi, Takumi

    2014-01-01

    The MAPK (mitogen-activated kinase) cascade plays important roles in plant perception of and reaction to developmental and environmental cues. Phosphoproteomics are useful to identify target proteins regulated by MAPK-dependent signaling pathway. Here, we introduce the quantitative phosphoproteomic analysis using a chemical labeling method. The isobaric tag for relative and absolute quantitation (iTRAQ) method is a MS-based technique to quantify protein expression among up to eight different samples in one experiment. In this technique, peptides were labeled by some stable isotope-coded covalent tags. We perform quantitative phosphoproteomics comparing Arabidopsis wild type and a stress-responsive mapkk mutant after phytotoxin treatment. To comprehensively identify the downstream phosphoproteins of MAPKK, total proteins were extracted from phytotoxin-treated wild-type and mapkk mutant plants. The phosphoproteins were purified by Pro-Q(®) Diamond Phosphoprotein Enrichment Kit and were digested with trypsin. Resulting peptides were labeled with iTRAQ reagents and were quantified and identified by MALDI TOF/TOF analyzer. We identified many phosphoproteins that were decreased in the mapkk mutant compared with wild type.

  20. Chromatographic Methods for the Analysis of Polyphenols in Wines

    Directory of Open Access Journals (Sweden)

    Medić-Šarić, M.

    2009-03-01

    Full Text Available Wine is an excellent source of various classes of polyphenols, including phenolic acids, flavonoids, and trihydroxystilbene resveratrol (Fig.1. Polyphenols play a major role in wine quality since they contribute to the sensory characteristics of wine, particularly color and astringency. A recent interest in these substances has been stimulated by abundant evidence of their beneficial effects on human health, such as anticarcinogenic, antiinflamatory and antimicrobial activities. Therefore, numerous studies have been performed in the attempt to analyze polyphenols in wine. This paper reviews the current advances in the determination of polyphenols in wine by the major chromatographic techniques such as thin-layer chromatography (TLC and high-performance liquid chromatography (HPLC.The great complexity of the polyphenolic content of wine and the difficulty in obtaining some of the standards usually require sample preparation before analysis. Two methods for sample preparation, liquid-liquid extraction and solid-phase extraction, are most commonly applied. Hydrolysis is applied frequently, but not exclusively, to remove the sugar moieties from glycosides.TLC on silica gel plates is useful for the rapid and low-cost separation and identification of the polyphenols present in wine (Fig. 2. Densitometric quantitative analysis of polyphenols in wine extracts is usually performed by scanning the TLC plates with UV light at wavelengths of 350–365 nm or 250–260 nm (Fig. 3. For the evaluation of the most efficient mobile phase and an optimal choice of the combination of two or more mobile phases, two methods may be applied: information theory and numerical taxonomy. HPLC currently represents the most popular technique for the analysis of polyphenols in wine. For this purpose, a reversed-phase HPLC method that uses gradient elution with binary elution system is usually employed. Routine detection is based on measurement of UV-Vis absorption with a diode