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Sample records for activated high gain

  1. High Power VCSEL Device with Periodic Gain Active Region

    2007-01-01

    High power vertical cavity surface emitting lasers(VCSEKLs) with large aperture have been fabricated through improving passivation, lateral oxidation and heat dissipation techniques. Different from conventional three quantum well structures, a periodic gain active region with nine quantum wells was incorporated into the VCSEL structure, with which high efficiency and high power operation were expected. The nine quantum wells were divided into three groups with each of them located at the antinodes of the ca...

  2. Photon-activated charge domain in high-gain photoconductive switches

    Wei Shi(施卫); Huiying Dai(戴慧莹); Xiaowei Sun(孙小卫)

    2003-01-01

    We report our experimental observation of charge domain oscillation in semi-insulating GaAs photoconductive semiconductor switches (PCSSs). The high-gain PCSS is intrinsically a photon-activated charge domain device. It is the photon-activated carriers that satisfy the requirement of charge domain formation on carrier concentration and device length product of 1012 cm-2. We also show that, because of the repeated process of domain formation, the domain travels with a compromised speed of electron saturation velocity and the speed of light. As a result, the transit time of charge domains in PCSS is much shorter than that of traditional Gunn domains.

  3. Arctigenin Inhibits Adipogenesis by Inducing AMPK Activation and Reduces Weight Gain in High-Fat Diet-Induced Obese Mice.

    Han, Yo-Han; Kee, Ji-Ye; Park, Jinbong; Kim, Hye-Lin; Jeong, Mi-Young; Kim, Dae-Seung; Jeon, Yong-Deok; Jung, Yunu; Youn, Dong-Hyun; Kang, JongWook; So, Hong-Seob; Park, Raekil; Lee, Jong-Hyun; Shin, Soyoung; Kim, Su-Jin; Um, Jae-Young; Hong, Seung-Heon

    2016-09-01

    Although arctigenin (ARC) has been reported to have some pharmacological effects such as anti-inflammation, anti-cancer, and antioxidant, there have been no reports on the anti-obesity effect of ARC. The aim of this study is to investigate whether ARC has an anti-obesity effect and mediates the AMP-activated protein kinase (AMPK) pathway. We investigated the anti-adipogenic effect of ARC using 3T3-L1 pre-adipocytes and human adipose tissue-derived mesenchymal stem cells (hAMSCs). In high-fat diet (HFD)-induced obese mice, whether ARC can inhibit weight gain was investigated. We found that ARC reduced weight gain, fat pad weight, and triglycerides in HFD-induced obese mice. ARC also inhibited the expression of peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer-binding protein alpha (C/EBPα) in in vitro and in vivo. Furthermore, ARC induced the AMPK activation resulting in down-modulation of adipogenesis-related factors including PPARγ, C/EBPα, fatty acid synthase, adipocyte fatty acid-binding protein, and lipoprotein lipase. This study demonstrates that ARC can reduce key adipogenic factors by activating the AMPK in vitro and in vivo and suggests a therapeutic implication of ARC for obesity treatment. J. Cell. Biochem. 117: 2067-2077, 2016. © 2016 Wiley Periodicals, Inc.

  4. The Use of Group Activities in Introductory Biology Supports Learning Gains and Uniquely Benefits High-Achieving Students

    Gili Marbach-Ad

    2016-12-01

    Full Text Available This study describes the implementation and effectiveness of small-group active engagement (GAE exercises in an introductory biology course (BSCI207 taught in a large auditorium setting. BSCI207 (Principles of Biology III—Organismal Biology is the third introductory core course for Biological Sciences majors. In fall 2014, the instructors redesigned one section to include GAE activities to supplement lecture content. One section (n = 198 employed three lectures per week. The other section (n = 136 replaced one lecture per week with a GAE class. We explored the benefits and challenges associated with implementing GAE exercises and their relative effectiveness for unique student groups (e.g., minority students, high- and low-grade point average [GPA] students. Our findings show that undergraduates in the GAE class exhibited greater improvement in learning outcomes than undergraduates in the traditional class. Findings also indicate that high-achieving students experienced the greatest benefit from GAE activities. Some at-risk student groups (e.g., two-year transfer students showed comparably low learning gains in the course, despite the additional support that may have been afforded by active learning. Collectively, these findings provide valuable feedback that may assist other instructors who wish to revise their courses and recommendations for institutions regarding prerequisite coursework approval policies.

  5. Sudden gains in behavioural activation for depression.

    Masterson, Ciara; Ekers, David; Gilbody, Simon; Richards, David; Toner-Clewes, Benjamin; McMillan, Dean

    2014-09-01

    Sudden gains have been linked to improved outcomes in cognitive behaviour therapy for depression. The relationship between sudden gains and outcome is less clear in other treatment modalities, including interpersonal psychotherapy and supportive expressive therapy, which may indicate different mechanisms of change between treatment modalities. The current study examined sudden gains in adults meeting diagnostic criteria for depression (N = 40) offered up to 12 sessions of behavioural activation treatment. Sudden gains were found in 42.5% of the sample. Sudden gains occurred early (median pre-gain session 2) and were related to outcome: those who experienced a sudden gain had significantly lower post-treatment scores on the PHQ-9. Furthermore, the proportion meeting the reliable and clinically significant change criteria at end of treatment was higher in the sudden gain group. These findings highlight the importance of understanding the mechanisms by which sudden gains relate to therapy outcome in behavioural activation.

  6. Active Microwave Metamaterials Incorporating Ideal Gain Devices

    Hao Xin

    2010-12-01

    Full Text Available Incorporation of active devices/media such as transistors for microwave and gain media for optics may be very attractive for enabling desired low loss and broadband metamaterials. Such metamaterials can even have gain which may very well lead to new and exciting physical phenomena. We investigate microwave composite right/left-handed transmission lines (CRLH-TL incorporating ideal gain devices such as constant negative resistance. With realistic lumped element values, we have shown that the negative phase constant of this kind of transmission lines is maintained (i.e., left-handedness kept while gain can be obtained (negative attenuation constant of transmission line simultaneously. Possible implementation and challenging issues of the proposed active CRLH-TL are also discussed.

  7. High-Performance 1.55-µm Superluminescent Diode Based on Broad Gain InAs/InGaAlAs/InP Quantum Dash Active Region

    Khan, Mohammed Zahed Mustafa

    2014-08-01

    We report on the high-performance characteristics from superluminescent diodes (SLDs) based on four-stack InAs/InGaAlAs chirped-barrier thickness quantum dash (Qdash) in a well structure. The active region exhibits a measured broad gain spectrum of 140 nm, with a peak modal gain of ~41 cm-1. The noncoated two-section gainabsorber broad-area and ridge-waveguide device configuration exhibits an output power of > 20 mW and > 12 mW, respectively. The corresponding -3-dB bandwidths span ~82 nm and ~72 nm, with a small spectral ripple of <; 0.2 dB, related largely to the contribution from dispersive height dash ensembles of the highly inhomogeneous active region. These C-L communication band devices will find applications in various cross-disciplinary fields of optical metrology, optical coherent tomography, etc.

  8. High-Gain Magnetized Inertial Fusion

    Slutz, Stephen A.; Vesey, Roger A.

    2012-01-01

    Magnetized inertial fusion (MIF) could substantially ease the difficulty of reaching plasma conditions required for significant fusion yields, but it has been widely accepted that the gain is not sufficient for fusion energy. Numerical simulations are presented showing that high-gain MIF is possible in cylindrical liner implosions based on the MagLIF concept [S. A. Slutz et al Phys. Plasmas 17, 056303 (2010)PHPAEN1070-664X10.1063/1.3333505] with the addition of a cryogenic layer of deuterium-tritium (DT). These simulations show that a burn wave propagates radially from the magnetized hot spot into the surrounding much denser cold DT given sufficient hot-spot areal density. For a drive current of 60 MA the simulated gain exceeds 100, which is more than adequate for fusion energy applications. The simulated gain exceeds 1000 for a drive current of 70 MA.

  9. Gain of harmonic generation in high gain free electron laser

    DENG Hai-Xiao; DAI Zhi-Min

    2008-01-01

    In a planar undulator employed free electron laser(FEL),each harmonic radiation starts from linear amplification and ends with nonlinear harmonic interactions of the lower nonlinear harmonics and the fundamental radiation.In this paper,we investigate the harmonic generation based on the dispersion relation driven from the coupled Maxwell-Vlasov equations,taking into account the effects due to energy spread,emittance,betatron oscillation of electron beam as well as diffraction guiding of the radiation field.A 3D universal scaling function for gain of the linear harmonic generation and a 1D universal scaling function for gain of the nonlinear harmonic generation are presented,which promise rapid computation in FEL design and optimization.The analytical approaches have been validated by 3D simulation results in large range.

  10. AN OVERVIEW OF THE DEVELOPMENT OF LOW GAIN FEEDBACK AND LOW-AND-HIGH GAIN FEEDBACK

    Zongli LIN

    2009-01-01

    Low gain feedback refers to certain families of stabilizing state feedback gains that are parameterized in a scalar and go to zero as the scalar decreases to zero. Low gain feedback was initially proposed to achieve semi-global stabilization of linear systems subject to input saturation. It was then combined with high gain feedback in different ways for solving various control problems. The resulting feedback laws are referred to as low-and-high gain feedback. Since the introduction of low gain feedback in the context of semi-global stabilization of linear systems subject to input saturation,there has been effort to develop alternative methods for low gain design, to characterize key features of low gain feedback, and to explore new applications of the low gain and low-and-high gain feedback.This paper reviews the developments in low gain and low-and-high gain feedback designs.

  11. Two-dimensional gain cross-grating based on spatial modulation of active Raman gain

    Wang, Li; Zhou, Feng-Xue; Guo, Hong-Ju; Niu, Yue-Ping; Gong, Shang-Qing

    2016-11-01

    Based on the spatial modulation of active Raman gain, a two-dimensional gain cross-grating is theoretically proposed. As the probe field propagates along the z direction and passes through the intersectant region of the two orthogonal standing-wave fields in the x-y plane, it can be effectively diffracted into the high-order directions, and the zero-order diffraction intensity is amplified at the same time. In comparison with the two-dimensional electromagnetically induced cross-grating based on electromagnetically induced transparency, the two-dimensional gain cross-grating has much higher diffraction intensities in the first-order and the high-order directions. Hence, it is more suitable to be utilized as all-optical switching and routing in optical networking and communication. Project supported by the National Natural Science Foundation of China (Grant Nos. 11274112 and 11347133).

  12. Hybrid optical antenna with high directivity gain.

    Bonakdar, Alireza; Mohseni, Hooman

    2013-08-01

    Coupling of a far-field optical mode to electronic states of a quantum absorber or emitter is a crucial process in many applications, including infrared sensors, single molecule spectroscopy, and quantum metrology. In particular, achieving high quantum efficiency for a system with a deep subwavelength quantum absorber/emitter has remained desirable. In this Letter, a hybrid optical antenna based on coupling of a photonic nanojet to a metallo-dielectric antenna is proposed, which allows such efficient coupling. A quantum efficiency of about 50% is predicted for a semiconductor with volume of ~λ³/170. Despite the weak optical absorption coefficient of 2000 cm(-1) in the long infrared wavelength of ~8 μm, very strong far-field coupling has been achieved, as evidenced by an axial directivity gain of 16 dB, which is only 3 dB below of theoretical limit. Unlike the common phased array antenna, this structure does not require coherent sources to achieve a high directivity. The quantum efficiency and directivity gain are more than an order of magnitude higher than existing metallic, dielectric, or metallo-dielectric optical antenna.

  13. Extended High-Gain Observer for Mars Entry Guidance

    Pingyuan Cui

    2013-02-01

    Full Text Available To deliver a Mars entry vehicle to the prescribed parachute deployment point, active entry guidance is essential. This paper addresses the problem of Mars atmospheric entry guidance through drag tracking method with extended high gain observer. First, an extended high gain observer combined with feedback linearization is applied in drag tracking for Mars entry longitudinal guidance.  The observer estimates the drag and drag rate for drag tracking, estimates the perturbation due to model uncertainty and disturbance, and compensate for the perturbation by canceling its estimate. Then, bank reversal is adopted in the lateral plane to reduce the cross-range error. Finally, Mars entry simulation is performed to assess the performance of the adaptive guidance law. The results demonstrate that the proposed guidance law exhibits good performance.

  14. High gain durable anti-reflective coating

    Maghsoodi, Sina; Brophy, Brenor L.; Colson, Thomas E.; Gonsalves, Peter R.; Abrams, Ze' ev R.

    2016-07-26

    Disclosed herein are polysilsesquioxane-based anti-reflective coating (ARC) compositions, methods of preparation, and methods of deposition on a substrate. In one embodiment, the polysilsesquioxane of this disclosure is prepared in a two-step process of acid catalyzed hydrolysis of organoalkoxysilane followed by addition of tetralkoxysilane that generates silicone polymers with >40 mol % silanol based on Si-NMR. These high silanol siloxane polymers are stable and have a long shelf-life in polar organic solvents at room temperature. Also disclosed are low refractive index ARC made from these compositions with and without additives such as porogens, templates, thermal radical initiator, photo radical initiators, crosslinkers, Si--OH condensation catalyst and nano-fillers. Also disclosed are methods and apparatus for applying coatings to flat substrates including substrate pre-treatment processes, coating processes and coating curing processes including skin-curing using hot-air knives. Also disclosed are coating compositions and formulations for highly tunable, durable, highly abrasion-resistant functionalized anti-reflective coatings.

  15. Simulation of Nonlinear Gain Saturation in Active Photonic Crystal Waveguides

    Chen, Yaohui; Mørk, Jesper

    2012-01-01

    In this paper we present a theoretical analysis of slowlight enhanced traveling wave amplification in an active semiconductor Photonic crystal waveguides. The impact of group index on nonlinear modal gain saturation is investigated.......In this paper we present a theoretical analysis of slowlight enhanced traveling wave amplification in an active semiconductor Photonic crystal waveguides. The impact of group index on nonlinear modal gain saturation is investigated....

  16. Nonlinear Gain Saturation in Active Slow Light Photonic Crystal Waveguides

    Chen, Yaohui; Mørk, Jesper

    2013-01-01

    We present a quantitative three-dimensional analysis of slow-light enhanced traveling wave amplification in an active semiconductor photonic crystal waveguides. The impact of slow-light propagation on the nonlinear gain saturation of the device is investigated.......We present a quantitative three-dimensional analysis of slow-light enhanced traveling wave amplification in an active semiconductor photonic crystal waveguides. The impact of slow-light propagation on the nonlinear gain saturation of the device is investigated....

  17. An output amplitude configurable wideband automatic gain control with high gain step accuracy

    何晓丰; 莫太山; 马成炎; 叶甜春

    2012-01-01

    An output amplitude configurable wideband automatic gain control (AGC) with high gain step accuracy for the GNSS receiver is presented.The amplitude of an AGC is configurable in order to cooperate with baseband chips to achieve interference suppression and be compatible with different full range ADCs.And what's more,the gain-boosting technology is introduced and the circuit is improved to increase the step accuracy.A zero,which is composed by the source feedback resistance and the source capacity,is introduced to compensate for the pole.The AGC is fabricated in a 0.18 μm CMOS process.The AGC shows a 62 dB gain control range by 1 dB each step with a gain error of less than 0.2 dB.The AGC provides 3 dB bandwidth larger than 80 MHz and the overall power consumption is less than 1.8 mA,and the die area is 800 × 300μm2.

  18. Design of a high linearity and high gain accuracy analog baseband circuit for DAB receiver

    Li, Ma; Zhigong, Wang; Jian, Xu; Yiqiang, Wu; Junliang, Wang; Mi, Tian; Jianping, Chen

    2015-02-01

    An analog baseband circuit of high linearity and high gain accuracy for a digital audio broadcasting receiver is implemented in a 0.18-μm RFCMOS process. The circuit comprises a 3rd-order active-RC complex filter (CF) and a programmable gain amplifier (PGA). An automatic tuning circuit is also designed to tune the CF's pass band. Instead of the class-A fully differential operational amplifier (FDOPA) adopted in the conventional CF and PGA design, a class-AB FDOPA is specially employed in this circuit to achieve a higher linearity and gain accuracy for its large current swing capability with lower static current consumption. In the PGA circuit, a novel DC offset cancellation technique based on the MOS resistor is introduced to reduce the settling time significantly. A reformative switching network is proposed, which can eliminate the switch resistor's influence on the gain accuracy of the PGA. The measurement result shows the gain range of the circuit is 10-50 dB with a 1-dB step size, and the gain accuracy is less than ±0.3 dB. The OIP3 is 23.3 dBm at the gain of 10 dB. Simulation results show that the settling time is reduced from 100 to 1 ms. The image band rejection is about 40 dB. It only draws 4.5 mA current from a 1.8 V supply voltage.

  19. A Novel High Gain DC-DC Step up Converter

    M. Al Mamun

    2016-07-01

    Full Text Available High gain dc-dc converters are widely used to maximize the energy harvest for renewable energy systems, for example, photovoltaic systems and fuel cell. Conventional boost converters usually operates at extreme duty cycle to obtain high voltage gain. Operation at extreme duty cycle leads to reverse recovery problem at the switches, high conduction loss, electromagnetic interference etc. This paper proposes a very high gain dc-dc step up converter operating at very low duty cycle (i.e. duty cycle <0.5. The additional advantage of the proposed converter is that a single control signal is used for the switches which reduces the operation complexity. The steady-state theoretical analysis described in this paper is finally verified by simulation results

  20. A SCALE-UP Mock-Up: Comparison of Student Learning Gains in High- and Low-Tech Active-Learning Environments

    Soneral, Paula A. G.; Wyse, Sara A.

    2017-01-01

    Student-centered learning environments with upside-down pedagogies (SCALE-UP) are widely implemented at institutions across the country, and learning gains from these classrooms have been well documented. This study investigates the specific design feature(s) of the SCALE-UP classroom most conducive to teaching and learning. Using pilot survey data from instructors and students to prioritize the most salient SCALE-UP classroom features, we created a low-tech “Mock-up” version of this classroom and tested the impact of these features on student learning, attitudes, and satisfaction using a quasi-­experimental setup. The same instructor taught two sections of an introductory biology course in the SCALE-UP and Mock-up rooms. Although students in both sections were equivalent in terms of gender, grade point average, incoming ACT, and drop/fail/withdraw rate, the Mock-up classroom enrolled significantly more freshmen. Controlling for class standing, multiple regression modeling revealed no significant differences in exam, in-class, preclass, and Introduction to Molecular and Cellular Biology Concept Inventory scores between the SCALE-UP and Mock-up classrooms. Thematic analysis of student comments highlighted that collaboration and whiteboards enhanced the learning experience, but technology was not important. Student satisfaction and attitudes were comparable. These results suggest that the benefits of a SCALE-UP experience can be achieved at lower cost without technology features. PMID:28213582

  1. SOFT-SWITCHED HIGH STEP-UP DC-DC CONVERTER WITH HIGH VOLTAGE GAIN

    J.C. PAUL IMMANUEL

    2013-04-01

    Full Text Available This paper presents a new design of soft switched high step-up dc-dc converter with high voltage gain which is suitable for high power applications such as Uninterruptible Power System (UPS, Photo Voltaic system and hybrid electric vehicles. The emergence of this front-end converter is to improve the shape of active input current given to the system. This converter proposes Soft-Switching technique to achieve ZVS turn on of active switches and ZCS turn off of diodes using Lr - Cr resonance in the auxiliary circuit. Therefore reduces the switching losses. Comparatively the voltage conversion ratio of this converter is higher when compared with the ordinary boost converter. Hence the voltage gain of this converter is also higher. A simulation platform is created using MATLAB which illustrates the ZVS and ZCS operation of the switches and diodes. Open loop and closed loop controlled converter systems are modelled and simulated.

  2. Dispersion relations for 1D high-gain FELs

    Webb, S.D.; Litvinenko, V.N.

    2010-08-23

    We present analytical results for the one-dimensional dispersion relation for high-gain FELs. Using kappa-n distributions, we obtain analytical relations between the dispersion relations for various order kappa distributions. Since an exact solution exists for the kappa-1 (Lorentzian) distribution, this provides some insight into the number of modes on the way to the Gaussian distribution.

  3. Optimization of Scatterer Concentration in High-Gain Scattering Media

    ZHU Jiu-Gao; ZHU He-Yuan; SUN Die-Chi; DU Ge-Guo; LI Fu-Ming

    2001-01-01

    We report the scatterer concentration-dependent behaviour of laser action in high-gain scattering media. Amodified model of a random laser is proposed to explain the experimental results in good agreement. We mayuse this modified model to design and optimize the random laser system. A further detailed model is needed toquantitatively analyse the far-field distribution of random laser action.

  4. A High Gain Omnidirectional Antenna Using Negative Permeability Metamaterial

    Hangfei Tang

    2013-01-01

    Full Text Available A high gain omnidirectional antenna with low profile is proposed and is investigated numerically and experimentally. Based on the conventional center-fed circular epsilon-negative (ENG zeroth-order resonator (ZOR antenna, dendritic structure negative permeability metamaterial (NPM is used as the substrate to enhance the gain of the omnidirectional antenna. The experimental results show that the gain of a center-fed circular ENG ZOR antenna with NPM substrate is enhanced about 2.2 dB, and the efficiency is enhanced about 38%, in the whole broad operating bandwidth as compared to that of the antenna without NPM substrate, which can be used to improve the reliability of wireless communications.

  5. Silicon photodiodes with high photoconductive gain at room temperature.

    Li, X; Carey, J E; Sickler, J W; Pralle, M U; Palsule, C; Vineis, C J

    2012-02-27

    Silicon photodiodes with high photoconductive gain are demonstrated. The photodiodes are fabricated in a complementary metal-oxide-semiconductor (CMOS)-compatible process. The typical room temperature responsivity at 940 nm is >20 A/W and the dark current density is ≈ 100 nA/cm2 at 5 V reverse bias, yielding a detectivity of ≈ 10(14) Jones. These photodiodes are good candidates for applications that require high detection sensitivity and low bias operation.

  6. 20 CFR 416.972 - What we mean by substantial gainful activity.

    2010-04-01

    ... INCOME FOR THE AGED, BLIND, AND DISABLED Determining Disability and Blindness Substantial Gainful Activity § 416.972 What we mean by substantial gainful activity. Substantial gainful activity is work activity that is both substantial and gainful: (a) Substantial work activity. Substantial work activity...

  7. STARS A Two Stage High Gain Harmonic Generation FEL Demonstrator

    M. Abo-Bakr; W. Anders; J. Bahrdt; P. Budz; K.B. Buerkmann-Gehrlein; O. Dressler; H.A. Duerr; V. Duerr; W. Eberhardt; S. Eisebitt; J. Feikes; R. Follath; A. Gaupp; R. Goergen; K. Goldammer; S.C. Hessler; K. Holldack; E. Jaeschke; Thorsten Kamps; S. Klauke; J. Knobloch; O. Kugeler; B.C. Kuske; P. Kuske; A. Meseck; R. Mitzner; R. Mueller; M. Neeb; A. Neumann; K. Ott; D. Pfluckhahn; T. Quast; M. Scheer; Th. Schroeter; M. Schuster; F. Senf; G. Wuestefeld; D. Kramer; Frank Marhauser

    2007-08-01

    BESSY is proposing a demonstration facility, called STARS, for a two-stage high-gain harmonic generation free electron laser (HGHG FEL). STARS is planned for lasing in the wavelength range 40 to 70 nm, requiring a beam energy of 325 MeV. The facility consists of a normal conducting gun, three superconducting TESLA-type acceleration modules modified for CW operation, a single stage bunch compressor and finally a two-stage HGHG cascaded FEL. This paper describes the faciliy layout and the rationale behind the operation parameters.

  8. Slow-light enhanced gain in active photonic crystal waveguides

    Ek, Sara; Chen, Yaohui; Semenova, Elizaveta; Yvind, Kresten; Mørk, Jesper

    2014-01-01

    Slow light is a fascinating physical effect, raising fundamental questions related to our understanding of light-matter interactions as well as offering new possibilities for photonic devices. From the first demonstrations of slow light propagation in ultra-cold atomic gasses, solid-state Ruby and photonic crystal structures, focus has shifted to applications, with slow light offering the ability to enhance and control light-matter interactions. The demonstration of tuneable delay lines, enhanced nonlinearities and spontaneous emission, enlarged spectral sensitivity and increased phase shifts illustrate the possibilities enabled by slow light propagation, with microwave photonics emerging as one of the promising applications. Here, we demonstrate that slow light can be used to control and increase the gain coefficient of an active semiconductor waveguide. The effect was theoretically predicted but not yet experimentally demonstrated. These results show a route towards realizing ultra-compact optical amplifier...

  9. Slow-light-enhanced gain in active photonic crystal waveguides

    Ek, Sara; Hansen, Per Lunnemann; Chen, Yaohui

    2014-01-01

    crystal structural parameters, the maximum value of the gain coefficient can be increased compared with a ridge waveguide structure and at the same time the spectral position of the peak gain be controlled. The experimental results are in qualitative agreement with theory and show that gain values similar...... to those realized in state-of-the-art semiconductor optical amplifiers should be attainable in compact photonic integrated amplifiers...

  10. Physical activity and fat mass gain in Mexican school-age children: a cohort study

    Jáuregui Alejandra

    2012-07-01

    Full Text Available Abstract Background In México, the prevalence of unhealthy weight increased from 24% at 6 y to 33% at 12 y of age, opening a window of opportunity to better understand the pathogenesis of obesity. The objective of this study was to explore the association between time spent on medium, vigorous physical activity (MVPA and concurrent gains in BMI, fat mass (FM and fat-free mass (FFM, alternately, in a cohort of Mexican children followed from kindergarten (baseline to 2nd grade elementary school (endline. Methods The MVPA (5-d accelerometry, BMI, FM and FFM (air displacement plethysmography were measured at baseline and endline. Associations between gains in BMI, FM and FFM and changes in MVPA were examined using lagged and dynamic regression models, controlling for energy intake and demographic variables. Results A total of 205 children were analyzed. Gender affected the effect of MVPA on FM gain. In girls, a high baseline MVPA predicted a lower FM gain (-0.96 kg, p=0.025 compared to low/medium MVPA. Increasing, decreasing or having a persistently high MVPA predicted a lower FM gain (range -1.6 to -1.03 kg, p Conclusion These results support a protective role of MVPA on FM gain in girls, suggesting that it may play a crucial role in the development of obesity. Further research on the gender effect of MVPA is warranted to better understand its role in the prevention and control of overweight and obesity.

  11. 20 CFR 229.85 - Substantial gainful activity by blind employee or child.

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Substantial gainful activity by blind... Reductions § 229.85 Substantial gainful activity by blind employee or child. A blind employee or child who is... substantial gainful activity that does not require skills or ability used in his or her previous work....

  12. Fast ignition integrated experiments and high-gain point design

    Shiraga, H. [Osaka Univ., Osaka (Japan); Nagatomo, H. [Osaka Univ., Osaka (Japan); Theobald, W. [Univ. of Rochester, Rochester, NY (United States); Solodov, A. A. [Univ. of Rochester, Rochester, NY (United States); Tabak, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2014-04-17

    Here, integrated fast ignition experiments were performed at ILE, Osaka, and LLE, Rochester, in which a nanosecond driver laser implodes a deuterated plastic shell in front of the tip of a hollow metal cone and an intense ultrashort-pulse laser is injected through the cone to heat the compressed plasma. Based on the initial successful results of fast electron heating of cone-in-shell targets, large-energy short-pulse laser beam lines were constructed and became operational: OMEGA-EP at Rochester and LFEX at Osaka. Neutron enhancement due to heating with a ~kJ short-pulse laser has been demonstrated in the integrated experiments at Osaka and Rochester. The neutron yields are being analyzed by comparing the experimental results with simulations. Details of the fast electron beam transport and the electron energy deposition in the imploded fuel plasma are complicated and further studies are imperative. The hydrodynamics of the implosion was studied including the interaction of the imploded core plasma with the cone tip. Theory and simulation studies are presented on the hydrodynamics of a high-gain target for a fast ignition point design.

  13. Recent progress in high gain InAs avalanche photodiodes (Presentation Recording)

    Bank, Seth; Maddox, Scott J.; Sun, Wenlu; Nair, Hari P.; Campbell, Joe C.

    2015-08-01

    InAs possesses nearly ideal material properties for the fabrication of near- and mid-infrared avalanche photodiodes (APDs), which result in strong electron-initiated impact ionization and negligible hole-initiated impact ionization [1]. Consequently, InAs multiplication regions exhibit several appealing characteristics, including extremely low excess noise factors and bandwidth independent of gain [2], [3]. These properties make InAs APDs attractive for a number of near- and mid-infrared sensing applications including remote gas sensing, light detection and ranging (LIDAR), and both active and passive imaging. Here, we discuss our recent advances in the growth and fabrication of high gain, low noise InAs APDs. Devices yielded room temperature multiplication gains >300, with much reduced (~10x) lower dark current densities. We will also discuss a likely key contributor to our current performance limitations: silicon diffusion into the intrinsic (multiplication) region from the underlying n-type layer during growth. Future work will focus on increasing the intrinsic region thickness, targeting gains >1000. This work was supported by the Army Research Office (W911NF-10-1-0391). [1] A. R. J. Marshall, C. H. Tan, M. J. Steer, and J. P. R. David, "Electron dominated impact ionization and avalanche gain characteristics in InAs photodiodes," Applied Physics Letters, vol. 93, p. 111107, 2008. [2] A. R. J. Marshall, A. Krysa, S. Zhang, A. S. Idris, S. Xie, J. P. R. David, and C. H. Tan, "High gain InAs avalanche photodiodes," in 6th EMRS DTC Technical Conference, Edinburgh, Scotland, UK, 2009. [3] S. J. Maddox, W. Sun, Z. Lu, H. P. Nair, J. C. Campbell, and S. R. Bank, "Enhanced low-noise gain from InAs avalanche photodiodes with reduced dark current and background doping," Applied Physics Letters, vol. 101, no. 15, pp. 151124-151124-3, Oct. 2012.

  14. High gain multigap avalanche detectors for Cerenkov ring imaging

    Gilmore, R.S.; Lavender, W.M.; Leith, D.W.G.S.; Williams, S.H.

    1980-10-01

    We report on a continuing study of multigap parallel plate avalanche chambers, primarily as photoelectron detectors for use with Cerenkov ring imaging counters. By suitable control of the fields in successive gaps and by introducing screens to reduce photon feedback to the cathode the gain many be increased considerably. We have obtained gains in excess of 6 x 10/sup 7/ for photoelectrons with a good pulse height spectrum and expect to increase this further. We discuss the use of resistive anodes to give avalanche positions in two dimensions by charge division.

  15. Role of surface in high photoconductive gain measured in ZnO nanowire-based photodetector

    Mallampati, Bhargav [University of North Texas, Department of Electrical Engineering (United States); Nair, S. V.; Ruda, H. E. [University of Toronto, Centre for Advanced Nanotechnology (Canada); Philipose, U., E-mail: usha.philipose@unt.edu [University of North Texas, Department of Physics (United States)

    2015-04-15

    On account of their large surface-to-volume ratio, nanowires contain an extremely high density of surface states which can lead to significantly enhanced photocarrier lifetimes resulting in persistent photoconductivity. There are reports that attribute the high photoconductive gain of ZnO nanowire-based photodetectors to hole trapping and de-trapping following oxygen adsorption and desorption from the nanowire surface. Through this work we provide experimental evidence of the role of surface and defects in carrier dynamics, resulting in enhanced photoresponse. ZnO nanowires with an average length of about 20 μm and diameters in the range of 60–80 nm were used in this experiment. Using intensity and temperature dependence of the rise and decay rate of photocurrent, we present a detailed analysis that provides an estimate of the activation energies of carrier trapping mechanisms. The high gain ZnO nanowire photodetector was sensitive to photoexcitation at or below 370 nm corresponding to the band-edge absorption profile of ZnO. At an incident wavelength of 370 nm and at a bias field of 5 kV/cm, it was found that the maximum responsivity is over 10{sup 5} A/W corresponding to an extremely high photoconductive gain of the order of 10{sup 6}. This corresponds to a normalized photoconductive gain of 4 × 10{sup −3} m{sup 2}V{sup −1}.

  16. Relationship of serum somatomedin-like activity and fibroblast proliferative activity with age and body weight gain in sheep.

    Olsen, R F; Wangsness, P J; Patton, W H; Martin, R J

    1981-01-01

    The relationship between serum growth factors and body weight gain was examined in five Dorset lambs. The lambs were weighed and bled by jugular puncture at 2-week intervals between 2 and 18 weeks of age. Somatomedin-like activity (Sm) declined from initially high concentrations at 2 weeks to fairly constant concentrations between 6 and 18 weeks. Relative weight gain--i.e., gain expressed as a percentage of body weight--declined in a manner similar to that of Sm. Mean relative weight gain and mean Sm for the eight 2-week intervals were significantly related (r = .84). Absolute body weight gain--i.e., gain expressed in kilograms--remained fairly constant throughout the study and was not significantly correlated to Sm (r = .15). Serum fibroblast proliferative activity (FPA) was measured as a possible indicator of collective activities of serum growth factors. FPA initially followed a pattern similar to that of Sm, decreasing between 2 and 6 weeks and plateauing until 12 weeks. After 12 weeks, FPA increased to concentrations similar to those observed at 2 weeks. The increase in FPA after 12 weeks was apparently due to an increase in a non-Sm growth factor and had no obvious relationship to body weight changes. Results of the in vitro cell assay system might have been more meaningful if cell type(s) other than WI-38 fibroblasts (e.g., myogenic cells) had been used for estimating collective activities of serum mitogenic factors. The data suggest that serum Sm-like activity may be important in the regulation of growth in sheep.

  17. Losses, gain, and lasing in organic and perovskite active materials (Conference Presentation)

    Pourdavoud, Neda; Riedl, Thomas J.

    2016-09-01

    Organic solid state lasers (OSLs) based on semiconducting polymers or small molecules have seen some significant progress over the past decade. Highly efficient organic gain materials combined with high-Q resonator geometries (distributed feedback (DFB), VCSEL, etc.) have enabled OSLs, optically pumped by simple inorganic laser diodes or even LEDs. However, some fundamental goals remain to be reached, like continuous wave (cw) operation and injection lasing. I will address various loss mechanisms related to accumulated triplet excitons or long-lived polarons that in combination with the particular photo-physics of organic gain media state the dominant road-blocks on the way to reach these goals. I will discuss the recent progress in fundamental understanding of these loss processes, which now provides a solid basis for modelling, e.g. of laser dynamics. Avenues to mitigate these fundamental loss mechanisms, e.g. by alternative materials will be presented. In this regard, a class of gain materials based on organo-lead halide perovskites re-entered the scene as light emitters, recently. Enjoying a tremendous lot of attention as active material for solution processed solar cells with a 20+% efficiency, they have recently unveiled their exciting photo-physics for lasing applications. Optically pumped lasing in these materials has been achieved. I will discuss some of the unique properties that render this class of materials a promising candidate to overcome some of the limitations of "classical" organic gain media.

  18. High Gain and High Directive of Antenna Arrays Utilizing Dielectric Layer on Bismuth Titanate Ceramics

    F. H. Wee

    2012-01-01

    Full Text Available A high gain and high directive microstrip patch array antenna formed from dielectric layer stacked on bismuth titanate (BiT ceramics have been investigated, fabricated, and measured. The antennas are designed and constructed with a combination of two-, four-, and six-BiT elements in an array form application on microwave substrate. For gain and directivity enhancement, a layer of dielectric was stacked on the BiT antenna array. We measured the gain and directivity of BiT array antennas with and without the dielectric layer and found that the gain of BiT array antenna with the dielectric layer was enhanced by about 1.4 dBi of directivity and 1.3 dB of gain over the one without the dielectric layer at 2.3 GHz. The impedance bandwidth of the BiT array antenna both with and without the dielectric layer is about 500 MHz and 350 MHz, respectively, which is suitable for the application of the WiMAX 2.3 GHz system. The utilization of BiT ceramics that covers about 90% of antenna led to high radiation efficiency, and small-size antennas were produced. In order to validate the proposed design, theoretical and measured results are provided and discussed.

  19. High Energy Gain IFEL at UCLA Neptune Laboratory

    Musumeci, Pietro; Clayton, Chris; Doyuran, Adnan; England, Robert J; Joshi, Chandrashekhar; Pellegrini, Claudio; Ralph, Joseph; Rosenzweig, James E; Sung, Chieh; Tochitsky, Sergei Ya; Tolmachev, Sergey; Travish, Gil; Varfolomeev, A; Varfolomeev, Alexander; Yarovoi, Timofey V; Yoder, Rodney

    2005-01-01

    We report the observation of energy gain in excess of 20 MeV at the Inverse Free Electron Laser Accelerator experiment at the Neptune Laboratory at UCLA. A 14.5 MeV electron beam is injected in an undulator strongly tapered in period and field amplitude. The IFEL driver is a CO2 10.6 mkm laser with power larger than 400 GW. The Rayleigh range of the laser, ~ 1.8 cm, is much shorter than the undulator length so that the interaction is diffraction dominated. A few per cent of the injected particles are trapped in a stable accelerating bucket. Electrons with energies up to 35 MeV are measured by a magnetic spectrometer. Simulations, in good agreement with the experimental data, show that most of the energy gain occurs in the first half of the undulator at a gradient of 70 MeV/m and that the structure in the measured energy spectrum arises because of higher harmonic IFEL interaction in the second half of the undulator.

  20. Exploring sudden gains in behavioral activation therapy for Major Depressive Disorder.

    Hunnicutt-Ferguson, Kallio; Hoxha, Denada; Gollan, Jackie

    2012-03-01

    Understanding the onset and course of sudden gains in treatment provides clinical information to the patient and clinician, and encourages clinicians to strive for these sudden clinical gains with their patients. This study characterizes the occurrence of sudden gains with Behavioral Activation (BA; Martell, Addis, & Jacobson, 2001), and the extent to which pre-treatment dysfunctional depressive thinking predicts sudden gains during treatment. We enrolled a sample of adults (n = 42) between ages 18-65 diagnosed with primary Major Depressive Disorder. All participants completed a 16-week course of BA, with clinical and self-report assessments at pre-, mid- and post-treatment. Results indicated that sudden gain and non-sudden gain participants showed differential improvement across treatment. No significant effects emerged for the dysfunctional cognitive style as a predictor of sudden gain status. Sudden gains may result from interaction of non-specific factors with the BA techniques implemented during early phases of therapy.

  1. A novel design of ultra-broadband, high-gain and high-linearity variable gain distributed amplifier in 0.13 μm CMOS technology

    Baharvand, Zainab; Hakimi, Ahmad; Rashedi, Esmat

    2016-12-01

    A high-gain, high-linearity and ultra-broadband variable gain distributed amplifier (VGDA) based on employing multiple techniques is presented to substantially increase the gain. The complete design is composed of two major parts including a VGDA part followed by a single stage distributed amplifier (SSDA) part. The VGDA part makes it possible to achieve different gain settings. For high gain considerations, the SSDA part cascades with the VGDA part that takes the benefits of the multiplicative gain mechanism. A theory is presented to enhance the linearity without imposing further DC power consumption. This idea has been validated by simulation results as expected. The design is analysed and simulated in the standard 0.13 μm CMOS technology. It presents the large gain tuning range of 35 dB, from -5 dB attenuation gain up to +30 dB maximum amplification gain, in relation to the control voltage (Vctr) that varies between 0.42 and 1.1 V. At the maximum amplification gain setting, it presents a DC up to 16 GHz 3 dB bandwidth, an average noise figure of 3.2 dB and an IIP3 of -2 dB m. Furthermore, it dissipates 46.42 mW from 0.7 and 0.9 V power supplies of the drain lines of VGDA and SSDA parts, respectively. Additionally, the Monte Carlo (MC) simulation has been performed to predict an estimate of the accuracy of performance of the proposed design under various conditions.

  2. SIW HIGH GAIN SLOT ANTENNA FOR WLAN/WIMAX APPLICATION

    Neda Akbari

    2014-01-01

    Full Text Available In this paper with using substrate integrated waveguide technology and slot antenna, an antenna array with 8 (2×4 elements has been designed. The antenna substrate is ROGERs 4003 with two different thickness. In lower substrate with 0.5 mm thickness fed network of antenna is putted and upper substrate with 1.5 mm thickness slot in order to radation is embedded. The proposed antenna is designed in C band for WLAN/WiMAX application. Pattern of antenna is directive with peak gain about 18dBi. In feed netowork is used from new method of feeding with using of aperture couple and cavity resonator method.

  3. There Is No Further Gain from Calculating Disease Activity Score in 28 Joints with High Sensitivity Assays of C-Reactive Protein Because of High Intraindividual Variability of CRP

    Jensen Hansen, Inger Marie; Asmussen Andreasen, Rikke; Antonsen, Steen

    2016-01-01

    Background/Purpose: The threshold for reporting of C-reactive protein (CRP) differs from laboratory to laboratory. Moreover, CRP values are affected by the intra individual biological variability.[1] With respect to disease activity score in 28 joints (DAS28) and Rheumatoid Arthritis (RA), precise...... reporting limit for CRP to minimumFigure 1). The logarithmic transformation of CRP in DAS28 formula has an important role Cross sectional study: 769 patients fulfilled the ACR criteria for RA were included, 107 excluded due to missing parameter used...

  4. There Is No Further Gain from Calculating Disease Activity Score in 28 Joints with High Sensitivity Assays of C-Reactive Protein Because of High Intraindividual Variability of CRP: A Cross Sectional Study and Theoretical Consideration

    Jensen Hansen, Inger Marie; Asmussen Andreasen, Rikke; Antonsen, Steen

    Background/Purpose: The threshold for reporting of C-reactive protein (CRP) differs from laboratory to laboratory. Moreover, CRP values are affected by the intra individual biological variability.[1] With respect to disease activity score in 28 joints (DAS28) and Rheumatoid Arthritis (RA), precise...... reporting limit for CRP to minimumFigure 1). The logarithmic transformation of CRP in DAS28 formula has an important role Cross sectional study: 769 patients fulfilled the ACR criteria for RA were included, 107 excluded due to missing parameter used...

  5. The Gain Properties of 1-D Active Photonic Crystal

    2003-01-01

    The terminology 'ID frequency'(w ID) is proposed after analyzing the 1D active photonic crystal based on the transfer matrix method. The relationship between wID and the structure parameters of the photonic crystal is investigated.

  6. High Gain Patch Antenna for 2.4GHz using Metamaterial Superstrate

    Kyu-Chang; LEE; Seung-In; YANG

    2010-01-01

    <正>A patch antenna and our proposed metamaterial patch antenna are simulated and compared. A high gain patch antenna using a single layer metamaterial superstrate with a near to zero refractive index(n)is proposed.The simulation results provide that the gain of the proposed antenna is increased by about 7dB. Consequently,the high gain antenna can be easily obtained by using our metamaterial superstrate.

  7. High gain 1.3-μm GaInNAs SOA with fast gain dynamics and enhanced temperature stability

    Fitsios, D.; Giannoulis, G.; Iliadis, N.; Korpijärvi, V.-M.; Viheriälä, J.; Laakso, A.; Dris, S.; Spyropoulou, M.; Avramopoulos, H.; Kanellos, G. T.; Pleros, N.; Guina, M.

    2014-03-01

    Semiconductor optical amplifiers (SOAs) are a well-established solution of optical access networks. They could prove an enabling technology for DataCom by offering extended range of active optical functionalities. However, in such costand energy-critical applications, high-integration densities increase the operational temperatures and require powerhungry external cooling. Taking a step further towards improving the cost and energy effectiveness of active optical components, we report on the development of a GaInNAs/GaAs (dilute nitride) SOA operating at 1.3μm that exhibits a gain value of 28 dB and combined with excellent temperature stability owing to the large conduction band offset between GaInNAs quantum well and GaAs barrier. Moreover, the characterization results reveal almost no gain variation around the 1320 nm region for a temperature range from 20° to 50° C. The gain recovery time attained values as short as 100 ps, allowing implementation of various signal processing functionalities at 10 Gb/s. The combined parameters are very attractive for application in photonic integrated circuits requiring uncooled operation and thus minimizing power consumption. Moreover, as a result of the insensitivity to heating issues, a higher number of active elements can be integrated on chip-scale circuitry, allowing for higher integration densities and more complex optical on-chip functions. Such component could prove essential for next generation DataCom networks.

  8. High Gain Hybrid Graphene-Organic Semiconductor Phototransistors

    Huisman, Everardus H.; Shulga, Artem G.; Zomer, Paul J.; Tombros, Nikolaos; Bartesaghi, Davide; Bisri, Satria Zulkarnaen; Loi, Maria A.; Koster, L. Jan Anton; van Wees, Bart J.

    2015-01-01

    Hybrid phototransistors of graphene and the organic semiconductor poly(3-hexylthiophene-2,5-diyl) (P3HT) are presented. Two types of phototransistors are demonstrated with a charge carrier transit time that differs by more than 6 orders of magnitude. High transit time devices are fabricated using a

  9. High gain durable anti-reflective coating with oblate voids

    Maghsoodi, Sina; Brophy, Brenor L.; Colson, Thomas E.; Gonsalves, Peter R.; Abrams, Ze' ev

    2016-06-28

    Disclosed herein are single layer transparent coatings with an anti-reflective property, a hydrophobic property, and that are highly abrasion resistant. The single layer transparent coatings contain a plurality of oblate voids. At least 1% of the oblate voids are open to a surface of the single layer transparent coatings.

  10. Optically-gated Non-latched High Gain Power Device

    2008-11-21

    INTENSITY MODULATION OF PSD SWITCHING DYNAMICS 39 5.1. Optically-modulated Active Gate Control (OMAG) architecture for full controllability of turn-on... architecture for next- generation avionics, electromagnetic interference (EMI) is a critical issue [2, 3]. EMI immunity of these actuators from external jamming...TlissMT (o] Ns * I utut*n I/a^l Rh-( J.52«5E»84 [ mVC ] I 0«| 1.20S2JE-02 [I/O cm] aloha =| 07t627 Ml: Bulk concenfcation M • Mobility O ! Bull

  11. Stabilization of sandwich non-linear systems with low-and-high gain feedback design

    Stoorvogel, Anton A.; Wang, Xu; Saberi, Ali; Sannuti, Peddapullaiah

    2010-01-01

    In this paper, we consider the problems of semi- global and global internal stabilization of a class of sandwich systems consisting of two linear systems with a saturation element in between. We develop here low-and-high gain and scheduled low-and-high gain state feedback design methodolo- gies to s

  12. Avalanche effect and gain saturation in high harmonic generation

    Serrat, Carles; Budesca, Josep M; Seres, Jozsef; Seres, Enikoe; Aurand, Bastian; Hoffmann, Andreas; Namba, Shinichi; Kuehl, Thomas; Spielmann, Christian

    2015-01-01

    Optical amplifiers in all ranges of the electromagnetic spectrum exhibit two essential characteristics: i) the input signal during the propagation in the medium is multiplied by the avalanche effect of the stimulated emission to produce exponential growth and ii) the amplification saturates at increasing input signal. We demonstrate that the strong-field theory in the frame of high harmonic generation fully supports the appearance of both the avalanche and saturation effects in the amplification of extreme ultraviolet attosecond pulse trains. We confirm that the amplification takes place only if the seed pulses are perfectly synchronized with the driving strong field in the amplifier. We performed an experimental study and subsequent model calculation on He gas driven by intense 30-fs-long laser pulses, which was seeded with an attosecond pulse train at 110 eV generated in a separated Ne gas jet. The comparison of the performed calculations with the measurements clearly demonstrates that the pumped He gas med...

  13. High-gain Yb:YAG amplifier for ultrashort pulse laser at high-average power

    Vetrovec, John; Copeland, Drew A.; Litt, Amardeep S.; Du, Detao

    2016-03-01

    We report on a Yb:YAG laser amplifier for ultrashort pulse applications at kW-class average power. The laser uses two large-aperture, disk-type gain elements fabricated from composite ceramic YAG material, and a multi-pass extraction architecture to obtain high gain in a chirped-pulse amplification system. The disks are edge-pumped, thus allowing for reduced doping of host material with laser ions, which translates to lower lasing threshold and lower heat dissipation in the Yb:YAG material. The latter makes it possible to amplify a near diffraction-limited seed without significant thermo-optical distortions. This work presents results of testing the laser amplifier with relay optics configured for energy extraction with up to 40 passes through the disks. Applications for the ultrashort pulse laser amplifier include producing laser-induced plasma channel, laser material ablation, and laser acceleration of atomic particles.

  14. Effects of high CO2 levels on dynamic photosynthesis: carbon gain, mechanisms, and environmental interactions.

    Tomimatsu, Hajime; Tang, Yanhong

    2016-05-01

    Understanding the photosynthetic responses of terrestrial plants to environments with high levels of CO2 is essential to address the ecological effects of elevated atmospheric CO2. Most photosynthetic models used for global carbon issues are based on steady-state photosynthesis, whereby photosynthesis is measured under constant environmental conditions; however, terrestrial plant photosynthesis under natural conditions is highly dynamic, and photosynthetic rates change in response to rapid changes in environmental factors. To predict future contributions of photosynthesis to the global carbon cycle, it is necessary to understand the dynamic nature of photosynthesis in relation to high CO2 levels. In this review, we summarize the current body of knowledge on the photosynthetic response to changes in light intensity under experimentally elevated CO2 conditions. We found that short-term exposure to high CO2 enhances photosynthetic rate, reduces photosynthetic induction time, and reduces post-illumination CO2 burst, resulting in increased leaf carbon gain during dynamic photosynthesis. However, long-term exposure to high CO2 during plant growth has varying effects on dynamic photosynthesis. High levels of CO2 increase the carbon gain in photosynthetic induction in some species, but have no significant effects in other species. Some studies have shown that high CO2 levels reduce the biochemical limitation on RuBP regeneration and Rubisco activation during photosynthetic induction, whereas the effects of high levels of CO2 on stomatal conductance differ among species. Few studies have examined the influence of environmental factors on effects of high levels of CO2 on dynamic photosynthesis. We identified several knowledge gaps that should be addressed to aid future predictions of photosynthesis in high-CO2 environments.

  15. Study on Dielectric Resonator Antenna with Annular Patch for High Gain and Large Bandwidth

    FENG Kuisheng; LI Na; MENG Qingwei; WANG Yongfeng; ZHANG Jingwei

    2015-01-01

    A new high-gain cylindrical Dielectric res-onator antenna (DRA) with a large bandwidth is proposed. A cylindrical Dielectric resonator (DR), a double-annular patch and a metallic cylinder are used to obtain a large bandwidth and a high gain. The mode TM12 excited in the patch is used to enhance the gain of the DRA, and the cavity formed by the metallic cylinder provides a further higher gain and a larger bandwidth. The measured results demonstrate that the proposed DRA achieves a large band-width of 23%from 5.3 to 6.8GHz with VSWR less than two and a high gain around 11 dBi.

  16. The Design of High-Q Sallen-Key Biquads with Unity-Gain Buffer Amplifiers

    Gaunholt, Hans; Guldbrandsen, Birthe

    1997-01-01

    and to implement the Sallen- Key biquad even in the high-Q case with reasonable sensitivities. The method is based on the unity gain version of the biquad and as unity gain buffer amplifiers are readily manufactured in integrated circuit technology the results may be very useful in the fabrication of integrated...

  17. Operation regimes, gain dynamics and highly stable operation points of Ho:YLF regenerative amplifiers

    Kroetz, Peter; Calendron, Anne-Laure; Chatterjee, Gourab; Cankaya, Huseyin; Murari, Krishna; Kaertner, Franz X; Hartl, Ingmar; Miller, R J Dwayne

    2016-01-01

    We present a comprehensive study of laser pulse amplification with respect to operation regimes, gain dynamics, and highly stable operation points of Ho:YLF regenerative amplifiers (RAs). The findings are expected to be more generic than for this specific case. Operation regimes are distinguished with respect to pulse energy and the appearance of pulse instability as a function of the repetition rate, seed energy, and pump intensity. The corresponding gain dynamics are presented, identifying highly stable operation points related to high gain build -up during pumping and high gain depletion during pulse amplification. These operation points are studied numerically and experimentally as a function of several parameters, thereby achieving, for our Ho:YLF RA, highly stable output pulses with measured fluctuations of only 0.19% (standard deviation).

  18. High But Not Low Probability of Gain Elicits a Positive Feeling Leading to the Framing Effect

    Gosling, Corentin J.; Moutier, Sylvain

    2017-01-01

    Human risky decision-making is known to be highly susceptible to profit-motivated responses elicited by the way in which options are framed. In fact, studies investigating the framing effect have shown that the choice between sure and risky options depends on how these options are presented. Interestingly, the probability of gain of the risky option has been highlighted as one of the main factors causing variations in susceptibility to the framing effect. However, while it has been shown that high probabilities of gain of the risky option systematically lead to framing bias, questions remain about the influence of low probabilities of gain. Therefore, the first aim of this paper was to clarify the respective roles of high and low probabilities of gain in the framing effect. Due to the difference between studies using a within- or between-subjects design, we conducted a first study investigating the respective roles of these designs. For both designs, we showed that trials with a high probability of gain led to the framing effect whereas those with a low probability did not. Second, as emotions are known to play a key role in the framing effect, we sought to determine whether they are responsible for such a debiasing effect of the low probability of gain. Our second study thus investigated the relationship between emotion and the framing effect depending on high and low probabilities. Our results revealed that positive emotion was related to risk-seeking in the loss frame, but only for trials with a high probability of gain. Taken together, these results support the interpretation that low probabilities of gain suppress the framing effect because they prevent the positive emotion of gain anticipation.

  19. High But Not Low Probability of Gain Elicits a Positive Feeling Leading to the Framing Effect.

    Gosling, Corentin J; Moutier, Sylvain

    2017-01-01

    Human risky decision-making is known to be highly susceptible to profit-motivated responses elicited by the way in which options are framed. In fact, studies investigating the framing effect have shown that the choice between sure and risky options depends on how these options are presented. Interestingly, the probability of gain of the risky option has been highlighted as one of the main factors causing variations in susceptibility to the framing effect. However, while it has been shown that high probabilities of gain of the risky option systematically lead to framing bias, questions remain about the influence of low probabilities of gain. Therefore, the first aim of this paper was to clarify the respective roles of high and low probabilities of gain in the framing effect. Due to the difference between studies using a within- or between-subjects design, we conducted a first study investigating the respective roles of these designs. For both designs, we showed that trials with a high probability of gain led to the framing effect whereas those with a low probability did not. Second, as emotions are known to play a key role in the framing effect, we sought to determine whether they are responsible for such a debiasing effect of the low probability of gain. Our second study thus investigated the relationship between emotion and the framing effect depending on high and low probabilities. Our results revealed that positive emotion was related to risk-seeking in the loss frame, but only for trials with a high probability of gain. Taken together, these results support the interpretation that low probabilities of gain suppress the framing effect because they prevent the positive emotion of gain anticipation.

  20. Very High Gain and Low Noise Near Infrared Single Photon Counting Detectors and Arrays Project

    National Aeronautics and Space Administration — Amplification Technologies Inc ("ATI") proposes to develop the enabling material and device technology for the design of ultra low noise, high gain and low...

  1. Detailed theoretical and experimental investigation of high-gain erbium-doped fiber amplifier

    Pedersen, Bo; Dybdal, Kristen; Dam-Hansen, Carsten

    1990-01-01

    A full-scale numerical model for the erbium-doped fiber amplifier has been developed that incorporates realistic index and erbium-concentration profiles as well as the spectral distribution of amplified spontaneous emission (ASE). The high accuracy of the model is demonstrated by comparison...... with a comprehensive set of data, including gain, ASE, and pump power, obtained for a well-characterized Er-Al-doped fiber. An absorption-to-emission cross-section ratio of 1.0 was measured at the gain peak. Pumping at 654 nm, the excited state absorption was observed to be insignificant. A high gain of 39.6 d...

  2. Microstructure-Fibre-Based Optical Parametric Amplification in Telecom Band with Ultra-High Gain Slope

    ZHANG Wei; XIAO Li; ZHANG Lei; HUANG Yi-Dong; PENG Jiang-De

    2006-01-01

    @@ We report a microstructure-fibre-based parametric amplification experiment in telecom band with ultra-high gain slope. A peak on-off gain of 52.3 dB is achieved using 25 m high nonlinear microstructure fibre (MF) and only 5.3 W pump power. The parametric gain slope is up to 580dBW-1 km-1. From the experimental data, the linear coefficient of the MF is estimated to be about 66. 7 W-1 km-1. The experiment shows the great potential of MFs in practical fibre parametric amplifiers.

  3. Gain and loss enhancement in active and passive particulate composite materials

    Mackay, Tom G

    2015-01-01

    Two active dielectric materials may be blended together to realize a homogenized composite material (HCM) which exhibits more gain than either component material. Likewise, two dissipative dielectric materials may be blended together to realize an HCM which exhibits more loss than either component material. Sufficient conditions for such gain/loss enhancement were established using the Bruggeman homogenization formalism. Gain/loss enhancement arises when (i) the imaginary parts of the relative permittivities of both component materials are similar in magnitude and (ii) the real parts of the relative permittivities of both component materials are dissimilar in magnitude.

  4. High-Gain AlxGa1-xAs/GaAs Transistors For Neural Networks

    Kim, Jae-Hoon; Lin, Steven H.

    1991-01-01

    High-gain AlxGa1-xAs/GaAs npn double heterojunction bipolar transistors developed for use as phototransistors in optoelectronic integrated circuits, especially in artificial neural networks. Transistors perform both photodetection and saturating-amplification functions of neurons. Good candidates for such application because structurally compatible with laser diodes and light-emitting diodes, detect light, and provide high current gain needed to compensate for losses in holographic optical elements.

  5. Polarization-insensitive optical gain characteristics of highly stacked InAs/GaAs quantum dots

    Kita, Takashi; Suwa, Masaya; Kaizu, Toshiyuki; Harada, Yukihiro [Department of Electrical and Electronic Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501 (Japan)

    2014-06-21

    The polarized optical gain characteristics of highly stacked InAs/GaAs quantum dots (QDs) with a thin spacer layer fabricated on an n{sup +}-GaAs (001) substrate were studied in the sub-threshold gain region. Using a 4.0-nm-thick spacer layer, we realized an electronically coupled QD superlattice structure along the stacking direction, which enabled the enhancement of the optical gain of the [001] transverse-magnetic (TM) polarization component. We systematically studied the polarized electroluminescence properties of laser devices containing 30 and 40 stacked InAs/GaAs QDs. The net modal gain was analyzed using the Hakki-Paoli method. Owing to the in-plane shape anisotropy of QDs, the polarization sensitivity of the gain depends on the waveguide direction. The gain showing polarization isotropy between the TM and transverse-electric polarization components is high for the [110] waveguide structure, which occurs for higher amounts of stacked QDs. Conversely, the isotropy of the [−110] waveguide is easily achieved even if the stacking is relatively low, although the gain is small.

  6. DEMONSTRATION OF 3D EFFECTS WITH HIGH GAIN AND EFFICIENCY IN A UV FEL OSCILLATOR

    Stephen Benson; George Biallas; Keith Blackburn; James Boyce; Donald Bullard; James Coleman; Cody Dickover; David Douglas; Forrest Ellingsworth; Pavel Evtushenko; Carlos Hernandez-Garcia; Christopher Gould; Joseph Gubeli; David Hardy; Kevin Jordan; John Klopf; James Kortze; Robert Legg; Matthew Marchlik; Steven Moore; George Neil; Thomas Powers; Daniel Sexton; Michelle D. Shinn; Christopher Tennant; Richard Walker; Anne Watson; Gwyn Williams; Frederick Wilson; Shukui Zhang

    2011-03-01

    We report on the performance of a high gain UV FEL oscillator operating on an energy recovery linac at Jefferson Lab. The high brightness of the electron beam leads to both gain and efficiency that cannot be reconciled with a one-dimensional model. Three-dimensional simulations do predict the performance with reasonable precision. Gain in excess of 100% per pass and an efficiency close to 1/2NW, where NW is the number of wiggler periods, is seen. The laser mirror tuning curves currently permit operation in the wavelength range of 438 to 362 nm. Another mirror set allows operation at longer wavelengths in the red with even higher gain and efficiency.

  7. Utilizing wideband AMC structures for high-gain inkjet-printed antennas on lossy paper substrate

    Cook, Benjamin Stassen

    2013-01-01

    Significant gain and bandwidth improvement of inkjet-printed antennas with integrated artificial magnetic conductor (AMC) is achieved by utilizing wideband ground-backed frequency selective surfaces (FSSs) to overcome the high losses of organic substrates such as paper. A microstrip-fed monopole mounted on an artificial magnetic conductor is demonstrated to improve the gain by 5 dB over previous works and exhibit much wider impedance bandwidth while maintaining a thin antenna profile and a 20% electrical size reduction. The effect of AMC bandwidth on substrate losses and the gain reduction caused by finite AMC array effects are investigated in an effort to produce high-gain, miniaturized, low-cost wearable and structure mount antennas. © 2013 IEEE.

  8. Telmisartan prevents weight gain and obesity through activation of peroxisome proliferator-activated receptor-delta-dependent pathways

    He, Hongbo; Yang, Dachun; Ma, Liqun

    2010-01-01

    -gamma expression, whereas neither candesartan nor losartan affected PPAR-delta expression. In vivo, long-term administration of telmisartan significantly reduced visceral fat and prevented high-fat diet-induced obesity in wild-type mice and hypertensive rats but not in PPAR-delta knockout mice. Administration...... and increased uncoupling protein 2 and 3 expression in skeletal muscle in wild-type mice but not in PPAR-delta knockout mice. We conclude that telmisartan prevents adipogenesis and weight gain through activation of PPAR-delta-dependent lipolytic pathways and energy uncoupling in several tissues.......)-delta-dependent pathways in several tissues. In vitro, telmisartan significantly upregulated PPAR-delta expression in 3T3-L1 preadipocytes in a time- and dose-dependent manner. Other than enhancing PPAR-delta expression by 68.2+/-17.3% and PPAR-delta activity by 102.0+/-9.0%, telmisartan also upregulated PPAR...

  9. Modeling of gain saturation effects in active semiconductor photonic crystal waveguides

    Chen, Yaohui; Mørk, Jesper

    2012-01-01

    In this paper, we present a theoretical analysis of slow-light enhanced light amplification in an active semiconductor photonic crystal line defect waveguide. The impact of enhanced light-matter interactions on carrier-depletion-induced modal gain saturation is investigated.......In this paper, we present a theoretical analysis of slow-light enhanced light amplification in an active semiconductor photonic crystal line defect waveguide. The impact of enhanced light-matter interactions on carrier-depletion-induced modal gain saturation is investigated....

  10. Shock-Ignited High Gain/Yield Targets for the National Ignition Facility

    Perkins, L. J.; Lafortune, K. N.; Bedrosiian, P.; Tabak, M.; Miles, A.; Dixit, S.; Betti, R.; Anderson, K.; Zhou, C.

    2006-10-01

    Shock-ignition, a new concept for ICF ignition [C.Zhou, R.Betti Bull APS, v50, 2005], is being studied as a future option for efficiently achieving high gains in large laser facilities such as NIF. Accordingly, this offers the potential for testing: (1)High yield (up to 200MJ), reactor-relevant targets for inertial fusion energy (2)High fusion yield targets for DOE NNSA stockpile application (3)Targets with appreciable gain at low laser drive energies (gains of 10's at 150kJ) (4)Ignition of simple, non-cryo (room temperature) single shell gas targets at (unity gain). By contrast to conventional hotspot ignition, we separate the assembly and ignition phases by initially imploding a massive cryogenic shell on a low adiabat (alpha 0.7) at low velocity (less than 2e7cm/s) using a direct drive pulse of modest total energy. The assembled fuel is then separately ignited by a strong, spherically convergent shock driven by a high intensity spike at the end of the pulse and timed to reach the center as the main fuel is stagnating and starting to rebound. Like fast ignition, shock ignition can achieve high gains with low drive energy, but has the advantages of requiring only a single laser with less demanding timing and spatial focusing requirements.

  11. Impact of gain saturation on the mode instability threshold in high-power fiber amplifiers

    Hansen, Kristian Rymann; Lægsgaard, Jesper

    2014-01-01

    We present a coupled-mode model of transverse mode instability in high-power fiber amplifiers, which takes the effect of gain saturation into account. The model provides simple semi-analytical formulas for the mode instability threshold, which are valid also for highly saturated amplifiers...

  12. High-gain X-ray free electron laser by beat-wave terahertz undulator

    Chang, Chao; Hei, DongWei [Science and Technology on High Power Microwave Laboratory, Northwest Institute of Nuclear Technology, Xi' an City 710024 (China); Institute of Energy, Tsinghua University, Beijing 100084 (China); Pellegrin, Claudio; Tantawi, Sami [SLAC National Accelerator Laboratory, Stanford University, Stanford, California 94309 (United States)

    2013-12-15

    The THz undulator has a higher gain to realize a much brighter X-ray at saturation, compared with the optical undulator under the same undulator strength and beam quality. In order to fill the high-power THz gap and realize the THz undulator, two superimposed laser pulses at normal incidence to the electron-beam moving direction form an equivalent high-field THz undulator by the frequency difference to realize the high-gain X-ray Free electron laser. The pulse front tilt of lateral fed lasers is used to realize the electron-laser synchronic interaction. By PIC simulation, a higher gain and a larger X-ray radiation power by the beat wave THz undulator could be realized, compared with the optical undulator for the same electron beam parameters.

  13. 78 FR 74125 - Agency Information Collection Activities; Comment Request; Measuring Educational Gain in the...

    2013-12-10

    ... Agency Information Collection Activities; Comment Request; Measuring Educational Gain in the National.... chapter 3501 et seq.), ED is proposing an extension of an existing information collection. DATES... submitted after the comment period will not be accepted. Written requests for information or...

  14. Gain optimization in fiber optical parametric amplifiers by combining standard and high-SBS threshold highly nonlinear fibers

    Da Ros, Francesco; Rottwitt, Karsten; Peucheret, Christophe

    2012-01-01

    Combining Al-doped and Ge-doped HNLFs as gain media in FOPAs is proposed and optimized, resulting in efficient SBS mitigation while circumventing the additional loss of the high SBS threshold Al-doped fiber.......Combining Al-doped and Ge-doped HNLFs as gain media in FOPAs is proposed and optimized, resulting in efficient SBS mitigation while circumventing the additional loss of the high SBS threshold Al-doped fiber....

  15. Adaptive control of linear multivariable systems with high frequency gain matrix hurwitz

    Ying ZHOU; Yuqiang WU; Shumin FEI

    2005-01-01

    A new adaptive control scheme is proposed for multivariable model reference adaptive control(MRAC) systems based on the nonlinear backstepping approach with vector form.The assumption on a priori knowledge of the high frequency gain matrix in existing results is relaxed and the new required condition for the high frequency gain matrix can be easily checked for certain plants so that the proposed method is widely applicable.This control scheme guarantees the global stability of the closed-loop systems and the tracking error can be arbitrary small.The simulation result for an application example shows the validity of the proposed nonlinear adaptive scheme.

  16. Very high-accuracy calibration of radiation pattern and gain of a near-field probe

    Pivnenko, Sergey; Nielsen, Jeppe Majlund; Breinbjerg, Olav

    2014-01-01

    In this paper, very high-accuracy calibration of the radiation pattern and gain of a near-field probe is described. An open-ended waveguide near-field probe has been used in a recent measurement of the C-band Synthetic Aperture Radar (SAR) Antenna Subsystem for the Sentinel 1 mission of the Europ......In this paper, very high-accuracy calibration of the radiation pattern and gain of a near-field probe is described. An open-ended waveguide near-field probe has been used in a recent measurement of the C-band Synthetic Aperture Radar (SAR) Antenna Subsystem for the Sentinel 1 mission...

  17. High-Directional Wave Propagation in Periodic Gain/Loss Modulated Materials

    Kumar, N; Herrero, R; Loiko, Yu; Staliunas, K

    2012-01-01

    Amplification/attenuation of light waves in artificial materials with a gain/loss modulation on the wavelength scale can be sensitive to the propagation direction. We give a numerical proof of the high anisotropy of the gain/loss in two dimensional periodic structures with square and rhombic lattice symmetry by solving the full set of Maxwell's equations using the finite difference time domain method. Anisotropy of amplification/attenuation leads to the narrowing of the angular spectrum of propagating radiation with wavevectors close to the edges of the first Brillouin Zone. The effect provides a novel and useful method to filter out high spatial harmonics from noisy beams.

  18. A Broadband and High Gain Tapered Slot Antenna for W-Band Imaging Array Applications

    Dong Sik Woo

    2014-01-01

    Full Text Available A broadband and high gain tapered slot antenna (TSA by utilizing a broadband microstrip- (MS- to-coplanar stripline (CPS balun has been developed for millimeter-wave imaging systems and sensors. This antenna exhibits ultrawideband performance for frequency ranges from 70 to over 110 GHz with the high antenna gain, low sidelobe levels, and narrow beamwidth. The validity of this antenna as imaging arrays is also demonstrated by analyzing mutual couplings and 4-element linear array. This antenna can be applied to mm-wave phased array, imaging array for plasma diagnostics applications.

  19. Enhanced optical precursors by Doppler effect via active Raman gain process.

    Peng, Yandong; Niu, Yueping; Zhang, Lida; Yang, Aihong; Jiang, Lin; Gong, Shangqing

    2012-08-15

    A scheme for enhancing precursor pulse by Doppler effect is proposed in a room-temperature active-Raman-gain medium. Due to abnormal dispersion between two gain peaks, main fields are advanced and constructively interfere with optical precursors, which leads to enhancement of the transient pulse at the rise edge of the input. Moreover, after Doppler averaging, the abnormal dispersion intensifies and the constructive interference between precursors and main fields is much strengthened, which boosts the transient spike. Simulation results demonstrate that the peak intensity of precursors could be enhanced nearly 20 times larger than that of the input.

  20. Inkjet Printing of Paper-Based Wideband and High Gain Antennas

    Cook, Benjamin

    2011-12-07

    This thesis represents a major contribution to wideband and high gain inkjet-printed antennas on paper. This work includes the complete characterization of the inkjet printing process for passive microwave devices on paper substrate as well as several ultra-wideband and high gain antenna designs. The characterization work includes the electrical characterization of the permittivity and loss tangent for paper substrate through 10 GHz, ink conductivity data for variable sintering conditions, and minimum feature sizes obtainable by today’s current inkjet processes for metallic nanoparticles. For the first time ever, inkjet-printed antennas are demonstrated that operate over the entire UWB band and demonstrate gains up to 8dB. This work also presents the first fractal-based inkjet-printed antennas with enhanced bandwidth and reduced production costs, and a novel slow wave log periodic dipole array which shows minimizations of 20% in width over conventional log periodic antennas.

  1. Improvement on a 2 × 2 Elements High-Gain Circularly Polarized Antenna Array

    C. Liu

    2015-01-01

    Full Text Available A novel antipodal Vivaldi antenna with tapering serrated structure at the edges is proposed. Compared with traditional Vivaldi antennas without serrated structure, the gain of the designed antenna is significantly improved in the desired frequency band (4.5–7.5 GHz. In addition, a 2 × 2 Vivaldi antenna array with an orthorhombic structure is designed and fabricated to achieve a circular polarization (CP characteristic. With this configuration, the 3 dB axial ratio bandwidth of the array reaches about 42% with respect to the center frequency of 6 GHz and a high gain is achieved as well. The novel Vivaldi antenna and CP antenna array both have ultrawide band (UWB and high-gain characteristics, which may be applied to the field of commercial communication, remote sensing, and so forth.

  2. Dynamic properties of a pulse-pumped fiber laser with a short, high-gain cavity

    Yang, Chaolin; Guo, Junhong; Wei, Pu; Wan, Hongdan; Xu, Ji; Wang, Jin

    2016-09-01

    We demonstrate a pulsed high-gain all-fiber laser without intracavity modulators, where a short and heavily Erbium-doped fiber is used as the gain medium in a ring cavity. By pulsed-pumping this short high gain cavity and tuning an intracavity variable optical coupler, the laser generates optical pulses with a pulse-width of μs at a repetition rate in the order of kHz down to one-shot operation. Furthermore, dynamic properties of this laser are investigated theoretically based on a traveling-wave-model, in which an adaptive-discrete-grid-finite-difference-method is applied. The simulation results validate the experimental results. The demonstrated pulsed laser is compact, flexible and cost-effective, which will have great potential for applications in all-optical sensing and communication systems.

  3. Enhancing speed of pinning synchronizability: low-degree nodes with high feedback gains

    Zhou, Ming-Yang; Liao, Hao; Fu, Zhong-Qian; Cai, Shi-Min

    2015-01-01

    Controlling complex networks is of paramount importance in science and engineering. Despite recent efforts to improve controllability and synchronous strength, little attention has been paid to the speed of pinning synchronizability (rate of convergence in pinning control) and the corresponding pinning node selection. To address this issue, we propose a hypothesis to restrict the control cost, then build a linear matrix inequality related to the speed of pinning controllability. By solving the inequality, we obtain both the speed of pinning controllability and optimal control strength (feedback gains in pinning control) for all nodes. Interestingly, some low-degree nodes are able to achieve large feedback gains, which suggests that they have high influence on controlling system. In addition, when choosing nodes with high feedback gains as pinning nodes, the controlling speed of real systems is remarkably enhanced compared to that of traditional large-degree and large-betweenness selections. Thus, the proposed...

  4. A high voltage gain quasi Z-source isolated DC/DC converter

    Siwakoti, Yam P.; Blaabjerg, Frede; Loh, Poh Chiang

    2014-01-01

    A compact quasi-Z-source DC/DC converter is presented with high voltage gain, isolated output, and improved efficiency. The improvements in size and performance were achieved by using a square wave inverter with only two output switches driving an isolating transformer in push-pull mode, followed...

  5. 75 FR 61228 - Board Meeting: Technical Lessons Gained From High-Level Nuclear Waste Disposal Efforts

    2010-10-04

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR WASTE TECHNICAL REVIEW BOARD Board Meeting: Technical Lessons Gained From High-Level Nuclear Waste Disposal Efforts Pursuant to its authority under section 5051 of Public Law 100-203, Nuclear Waste Policy Amendments Act...

  6. Review on High Gain Conical Horn Antenna for Short-Range Communications

    Priyanka Bhagwat

    2013-11-01

    Full Text Available Horn antennas are very popular at UHF (300 MHz-3 GHz and higher frequencies ( as high as 140 GHz. Horn antennas often have a directional radiation pattern with a high antenna gain, which can range up to 25 dB in some cases, with 10-20 dB being typical. Horn antennas have a wide impedance bandwidth, implying that the input impedance is slowly varying over a wide frequency range. The bandwidth for practical horn antennas can be of the order of 20:1 (for instance, operating from 1 GHz-20 GHz, with a 10:1 bandwidth being common. The gain of horn antennas often increases as the frequency of operation is increased. This is because the size of the horn aperture is measured in wavelengths; at higher frequencies the horn antenna is "electrically larger" because high frequency has a smaller wavelength. Horn antennas have very little loss, so the directivity of a horn is roughly equal to its gain. In this paper, we will present review about conical horn antenna which uses hybrid technique and provides high gain at frequencies ranging 3GHz keeping its size within limits. Also, literature survey will demostrate other reference papers will includes horn antennas using different techniques and used for various applications.

  7. High-Current Gain Two-Dimensional MoS 2 -Base Hot-Electron Transistors

    Torres, Carlos M.

    2015-12-09

    The vertical transport of nonequilibrium charge carriers through semiconductor heterostructures has led to milestones in electronics with the development of the hot-electron transistor. Recently, significant advances have been made with atomically sharp heterostructures implementing various two-dimensional materials. Although graphene-base hot-electron transistors show great promise for electronic switching at high frequencies, they are limited by their low current gain. Here we show that, by choosing MoS2 and HfO2 for the filter barrier interface and using a noncrystalline semiconductor such as ITO for the collector, we can achieve an unprecedentedly high-current gain (α ∼ 0.95) in our hot-electron transistors operating at room temperature. Furthermore, the current gain can be tuned over 2 orders of magnitude with the collector-base voltage albeit this feature currently presents a drawback in the transistor performance metrics such as poor output resistance and poor intrinsic voltage gain. We anticipate our transistors will pave the way toward the realization of novel flexible 2D material-based high-density, low-energy, and high-frequency hot-carrier electronic applications. © 2015 American Chemical Society.

  8. Prior exercise training blunts short-term high-fat diet-induced weight gain.

    Snook, Laelie A; MacPherson, Rebecca E K; Monaco, Cynthia M F; Frendo-Cumbo, Scott; Castellani, Laura; Peppler, Willem T; Anderson, Zachary G; Buzelle, Samyra L; LeBlanc, Paul J; Holloway, Graham P; Wright, David C

    2016-08-01

    High-fat diets rapidly cause weight gain and glucose intolerance. We sought to determine whether these changes could be mitigated with prior exercise training. Male C57BL/6J mice were exercise-trained by treadmill running (1 h/day, 5 days/wk) for 4 wk. Twenty-four hours after the final bout of exercise, mice were provided with a high-fat diet (HFD; 60% kcal from lard) for 4 days, with no further exercise. In mice fed the HFD prior to exercise training, the results were blunted weight gain, reduced fat mass, and a slight attenuation in glucose intolerance that was mirrored by greater insulin-induced Akt phosphorylation in skeletal muscle compared with sedentary mice fed the HFD. When ad libitum-fed sedentary mice were compared with sedentary high-fat fed mice that were calorie restricted (-30%) to match the weight gain of the previously trained high-fat fed mice, the same attenuated impairments in glucose tolerance were found. Blunted weight gain was associated with a greater capacity to increase energy expenditure in trained compared with sedentary mice when challenged with a HFD. Although mitochondrial enzymes in white adipose tissue and UCP-1 protein content in brown adipose tissue were increased in previously exercised compared with sedentary mice fed a HFD, ex vivo mitochondrial respiration was not increased in either tissue. Our data suggest that prior exercise training attenuates high-fat diet-induced weight gain and glucose intolerance and is associated with a greater ability to increase energy expenditure in response to a high-fat diet.

  9. High-precision gas gain and energy transfer measurements in Ar–CO2 mixtures

    Şahin, Özkan; Veenhof, Rob

    2014-01-01

    Ar–CO2 is a Penning mixture since a fraction of the energy stored in Ar 3p53d3p53d and higher excited states can be transferred to ionize CO2 molecules. In the present work, concentration and pressure dependence of Penning transfer rate and photon feedback parameter in Ar–CO2 mixtures have been investigated with recent systematic high-precision gas gain measurements which cover the range 1–50% CO2 at 400, 800, 1200, 1800 hPa and gas gain from 1 to 5×105.

  10. High-precision gas gain and energy transfer measurements in Ar–CO{sub 2} mixtures

    Şahin, Özkan, E-mail: osahin@uludag.edu.tr [Department of Physics, Uludağ University, 16059 Bursa (Turkey); Kowalski, Tadeusz Z. [Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Kraków (Poland); Veenhof, Rob [Department of Physics, Uludağ University, 16059 Bursa (Turkey); RD51 collaboration, CERN, Genève (Switzerland)

    2014-12-21

    Ar–CO{sub 2} is a Penning mixture since a fraction of the energy stored in Ar 3p{sup 5}3d and higher excited states can be transferred to ionize CO{sub 2} molecules. In the present work, concentration and pressure dependence of Penning transfer rate and photon feedback parameter in Ar–CO{sub 2} mixtures have been investigated with recent systematic high-precision gas gain measurements which cover the range 1–50% CO{sub 2} at 400, 800, 1200, 1800 hPa and gas gain from 1 to 5×10{sup 5}.

  11. Design on X-band Wideband and High-gain Multi-layer Microstrip Antenna

    Soufian LAKRIT

    2014-07-01

    Full Text Available In this paper, a wide-band and high-gain microstrip antenna with mullti-layer microstrip patch and an aperture-coupled feeding is proposed. The antenna has a condensed structure where the dimension is about 8.5mm by 7.5mm by 4.662mm leading to good bandwidths covering 8.05 GHz to 12.01 GHz (39.48%, and the gain is up to 5.23dB. The low expenses of this profile and its simple configuration allows for an its easy fabrication, with appropriation with wireless and satellite communication.

  12. Design on X-band Wideband and High-gain Multi-layer Microstrip Antenna

    Soufian LAKRIT; Hassan AMMOR

    2014-01-01

    In this paper, a wide-band and high-gain microstrip antenna with mullti-layer microstrip patch and an aperture-coupled feeding is proposed. The antenna has a condensed structure where the dimension is about 8.5mm by 7.5mm by 4.662mm leading to good bandwidths covering 8.05 GHz to 12.01 GHz (39.48%), and the gain is up to 5.23dB. The low expenses of this profile and its simple configuration allows for an its easy fabrication, with appropriation with wireless and satellite communica...

  13. Quantum limited noise figure operation of high gain erbium doped fiber amplifiers

    Lumholt, Ole; Povlsen, Jørn Hedegaard; Schüsler, Kim;

    1993-01-01

    powers below -5 dBm, and an improvement of 2.0 dB with a simultaneous gain increase of 4.1 dB is measured relative to a gain-optimized fiber. The optimum isolator location is evaluated for different pump and signal wavelengths in both an Al/Er-doped and a Ge/Er-doped fiber, for pump and signal power......Performance improvements obtained by using an isolator as an amplified-spontaneous-emission-suppressing component within erbium-doped fibers are evaluated. Simultaneous high-gain and near-quantum-limited noise figures can be obtained by such a scheme. The noise figure improves for input signal...... variations and different pump configurations. In all cases the optimum isolator position lies within 10-37% of the total fiber length for small signal operation...

  14. Magnetically coupled high-gain Y-source isolated DC/DC converter

    Siwakoti, Yam P.; Loh, Poh Chiang; Blaabjerg, Frede;

    2014-01-01

    A new form of magnetically coupled DC/DC converter is proposed for medium power applications (250 W to 2 kW), requiring a high-voltage gain, short inductive charging time and galvanic isolation. The proposed converter can be realised using a unique Y-source impedance network and a two-switch push......-pull circuit with voltage-doubling rectification. The converter's voltage gain is presently not matched by any other converter operating at the same switch duty ratio. The converter also has more degrees of freedom in design for setting the desired gain than other converters, and hence can better meet...... the demands of many applications. The operating principles of the converter have been analysed mathematically, and are verified by both simulation and experiment....

  15. Millimeter Wave Fabry-Perot Resonator Antenna Fed by CPW with High Gain and Broadband

    Xue-Xia Yang

    2016-01-01

    Full Text Available A novel millimeter wave coplanar waveguide (CPW fed Fabry-Perot (F-P antenna with high gain, broad bandwidth, and low profile is reported. The partially reflective surface (PRS and the ground form the F-P resonator cavity, which is filled with the same dielectric substrate. A dual rhombic slot loop on the ground acts as the primary feeding antenna, which is fed by the CPW and has broad bandwidth. In order to improve the antenna gain, metal vias are inserted surrounding the F-P cavity. A CPW-to-microstrip transition is designed to measure the performances of the antenna and extend the applications. The measured impedance bandwidth of S11 less than −10 dB is from 34 to 37.7 GHz (10.5%, and the gain is 15.4 dBi at the center frequency of 35 GHz with a 3 dB gain bandwidth of 7.1%. This performance of the antenna shows a tradeoff among gain, bandwidth, and profile.

  16. Design of anisotropic focusing metasurface and its application for high-gain lens antenna

    Guo, Wenlong; Wang, Guangming; Li, Haipeng; Li, Tangjing; Ge, Qichao; Zhuang, Yaqiang

    2017-03-01

    In this paper, we propose an anisotropic focusing metasurface with function of focusing orthogonally polarized waves in refraction and reflection modes respectively. By employing four layered metallic patches spaced by triple layered dielectric spacers, an anisotropic phase element is designed with capability of transmitting x-polarized waves but reflecting y-polarized beams efficiently. Composed of 21 × 21 cells and with size of 105 × 105 mm2, a focusing metasurface operating at 15 GHz is designed with the same focal length of 30 mm for x- and y-polarized waves. By setting a patch antenna at the focal point, the metasurface sample is employed to enhance gain of the radiation source. For verification, the metasurface sample is fabricated and measured. The antenna performance, in terms of realized boresight gain and operating bandwidth under x- and y-polarized waves illumination, is presented. Results show that the 1 dB gain bandwidths are respectively from 14.7 to 15.3 GHz and 14.7 to 15.2 GHz, and the gain are enhanced by 14.1 dB, 15.1 dB in refraction and reflection modes when the metasurface is impinged by x- and y-polarized spherical waves. The proposed anisotropic metasurface may afford an alternative for designing anisotropic planar lens or high-gain antenna.

  17. High gain GaAs photoconductive semiconductor switches for ground penetrating radar

    Loubriel, G.M.; Aurand, J.F.; Buttram, M.T.; Zutavern, F.J.; Helgeson, W.D.; O`Malley, M.W. [Sandia National Labs., Albuquerque, NM (United States); Brown, D.J. [Ktech Corp., Albuquerque, NM (United States)

    1996-07-01

    The ability of high gain GaAs Photoconductive Semiconductor switches (PCSS) to deliver high peak power, fast risetime pulses when triggered with small laser diode arrays makes them suitable for their use in radars that rely on fast impulses. This type of direct time domain radar is uniquely suited for observation of large structures under ground because it can operate at low frequencies and at high average power. This paper will summarize the state-of-the-art in high gain GaAs switches and discuss their use in a radar transmitter. We will also present a summary of an analysis of the effectiveness of different pulser geometries that result in transmitted pulses with varying frequency content. To this end we developed a simple model that includes transmit and receive antenna response, attenuation and dispersion of the electromagnetic impulses by the soil, and target cross sections.

  18. A Coherent Compton Backscattering High Gain FEL using an X-Band Microwave Undulator

    Tantawi, S.; Dolgashev, V.; Nantista, C.; /SLAC; Pellegrini, C.; Rosenzweig, J.; Travish, G.; /UCLA

    2005-12-14

    High power microwave sources at X-Band, delivering 400 to 500 of megawatts for about 400 ns, have been recently developed. These sources can power a microwave undulator with short period and large gap, and can be used in short wavelength FELs reaching the nm region at a beam energy of about 1 GeV. We present here an experiment designed to demonstrate that microwave undulators have the field quality needed for high gain FELs.

  19. Femtosecond Ti:sapphire cryogenic amplifier with high gain and MHz repetition rate

    Dantan, Aurelien Romain; Laurat, Julien; Ourjoumtsev, Alexei;

    2007-01-01

    We demonstrate high gain amplification of 160-femtosecond pulses in a compact double-pass cryogenic Ti:sapphire amplifier. The setup involves a negative GVD mirrors recompression stage, and operates with a repetition rate between 0.2 and 4 MHz with a continuous pump laser. Amplification factors...... as high as 17 and 320 nJ Fourier-limited pulses are obtained at a 800 kHz repetition rate....

  20. Pregnant women's perceptions of weight gain, physical activity, and nutrition using Theory of Planned Behavior constructs.

    Whitaker, Kara M; Wilcox, Sara; Liu, Jihong; Blair, Steven N; Pate, Russell R

    2016-02-01

    A better understanding of women's perceptions of weight gain and related behaviors during pregnancy is necessary to inform behavioral interventions. We used the Theory of Planned Behavior (TPB) to examine pregnant women's perceptions and intentions toward weight gain, physical activity (PA), and nutrition using a mixed methods study design. Women between 20 and 30 weeks gestation (n = 189) were recruited to complete an Internet-based survey. Salient beliefs toward weight gain, PA, and nutrition were captured through open-ended responses and content analyzed into themes. TPB constructs (attitude, subjective norm, perceived behavioral control, intentions) were examined using Pearson correlations and hierarchical linear regression models. Salient beliefs were consistent with the existing literature in non-pregnant populations, with the addition of many pregnancy-specific beliefs. TPB constructs accounted for 23-39 % of the variance in weight gain, PA, and nutrition intentions, and made varying contributions across outcomes. The TPB is a useful framework for examining women's weight-related intentions during pregnancy. Study implications for intervention development are discussed.

  1. Whey protein reduces early life weight gain in mice fed a high-fat diet

    Tranberg, Britt; Hellgren, Lars; Lykkesfeldt, Jens;

    2013-01-01

    An increasing number of studies indicate that dairy products, including whey protein, alleviate several disorders of the metabolic syndrome. Here, we investigated the effects of whey protein isolate (whey) in mice fed a high-fat diet hypothesising that the metabolic effects of whey would...... be associated with changes in the gut microbiota composition. Five-week-old male C57BL/6 mice were fed a high-fat diet ad libitum for 14 weeks with the protein source being either whey or casein. Faeces were collected at week 0, 7, and 13 and the fecal microbiota was analysed by denaturing gradient gel...... reduced weight gain in young C57BL/6 mice fed a high-fat diet compared to casein. Although the effect on weight gain ceased, whey alleviated glucose intolerance, improved insulin sensitivity and reduced plasma cholesterol. These findings could not be explained by changes in food intake or gut microbiota...

  2. Excess Folic Acid Increases Lipid Storage, Weight Gain, and Adipose Tissue Inflammation in High Fat Diet-Fed Rats

    Karen B. Kelly

    2016-09-01

    Full Text Available Folic acid intake has increased to high levels in many countries, raising concerns about possible adverse effects, including disturbances to energy and lipid metabolism. Our aim was to investigate the effects of excess folic acid (EFA intake compared to adequate folic acid (AFA intake on metabolic health in a rodent model. We conducted these investigations in the setting of either a 15% energy low fat (LF diet or 60% energy high fat (HF diet. There was no difference in weight gain, fat mass, or glucose tolerance in EFA-fed rats compared to AFA-fed rats when they were fed a LF diet. However, rats fed EFA in combination with a HF diet had significantly greater weight gain and fat mass compared to rats fed AFA (p < 0.05. Gene expression analysis showed increased mRNA levels of peroxisome proliferator-activated receptor γ (PPARγ and some of its target genes in adipose tissue of high fat-excess folic acid (HF-EFA fed rats. Inflammation was increased in HF-EFA fed rats, associated with impaired glucose tolerance compared to high fat-adequate folic acid (HF-AFA fed rats (p < 0.05. In addition, folic acid induced PPARγ expression and triglyceride accumulation in 3T3-L1 cells. Our results suggest that excess folic acid may exacerbate weight gain, fat accumulation, and inflammation caused by consumption of a HF diet.

  3. High-energy electron induced gain degradation in bipolar junction transistors

    Kulkarni, S.R. [Department of PG Studies in Physics, SBMJC, Jayanagar, Bangalore 560 011 (India)]. E-mail: srinivask24@hotmail.com; Ravindra, M. [Components Division, ICG, ISRO Satellite Centre, Airport Road, Bangalore 560 017 (India); Joshi, G.R. [Components Division, ICG, ISRO Satellite Centre, Airport Road, Bangalore 560 017 (India); Damle, R. [Department of Physics, Bangalore University, Bangalore 560 056 (India)]. E-mail: damleraju@yahoo.com

    2006-09-15

    This paper describes the effect of 8 MeV electron beam on the forward current gain of space borne commercial indigenous bipolar junction transistors 2N2219A (npn), 2N3019 (npn) and 2N2905A (pnp). The devices are exposed to 8 MeV electron in the biased condition. The collector characteristics and Gummel plots are obtained as a function of accumulated dose. An excess base current model as well as Messenger-Spratt equation have been used to account for the observed gain degradation. The results indicate that 8 MeV electrons of high dose rate induce gain degradation by increasing the base current as well as decrease in collector current. The current gain degradation appears to be predominantly due to displacement damage in the bulk of the transistor. Off-line measurements of the h {sub FE} of the irradiated transistors indicate that the displacement induced defect and recombination centers do not anneal even at 150 {sup o}C.

  4. High power double-scale pulses from a gain-guided double-clad fiber laser

    Zhang, Haitao; Gao, Gan; Li, Qinghua; Gong, Mali

    2017-03-01

    Generation of high power double-scale pulses from a gain-guided double-clad fiber laser is experimentally demonstrated. By employing the Yb-doped 10/130 double-clad fiber as the gain medium, the laser realizes an output power of 5.1 W and pulse energy of 0.175 µJ at repetition rate of 29.14 MHz. To the best of our knowledge, this average output power is the highest among the reported double-scale pulse oscillators. The autocorrelation trace of pulses contains the short (98 fs) and long (29.5 ps) components, and the spectral bandwidth of the pulse is 27.3 nm. Such double-scale pulses are well suited for seeding the high power MOPA (master oscillator power amplifier) systems, nonlinear frequency conversion and optical coherence tomography.

  5. First lasing of a high-gain harmonic generation free- electron laser experiment

    Yu, L H; Ben-Zvi, I; Di Mauro, Louis F; Doyuran, A; Graves, W; Johnson, E; Krinsky, S; Malone, R; Pogorelsky, I V; Skaritka, J; Rakowsky, G; Solomon, L; Wang, X J; Woodle, M; Yakimenko, V; Biedron, S G; Galayda, J N; Gluskin, E; Jagger, J; Sajaev, Vadim; Vasserman, I

    2000-01-01

    We report on the first lasing of a high-gain harmonic generation (HGHG) free-electron laser (FEL). The experiment was conducted at the Accelerator Test Facility (ATF) at Brookhaven National Laboratory (BNL). This is a BNL experiment in collaboration with the Advanced Photon Source (APS) at Argonne National Laboratory. A preliminary measurement gives a high-gain harmonic generation (HGHG) pulse energy that is 2x10 sup 7 times larger than the spontaneous radiation. In a purely self-amplified spontaneous emission (SASE) mode of operation, the signal was measured as 10 times larger than the spontaneous radiation in the same distance (approx 2 m) through the same wiggler. This means the HGHG signal is 2x10 sup 6 times larger than the SASE signal. To obtain the same saturated output power by the SASE process, the radiator would have to be 3 times longer (6 m).

  6. Nonlinear harmonics in the high-gain harmonic generation (HGHG) experiment

    Biedron, S G; Milton, S V; Yu, L H; Wang, X J

    2001-01-01

    We have previously performed rigorous analyses of the nonlinear harmonics in self-amplified spontaneous emission (SASE) free-electron lasers (FELs) using a 3D simulation code. To date, we have presented only preliminary results of these higher harmonics resulting in the high-gain harmonic generation (HGHG) process. A single-pass, high-gain FEL experiment based on the HGHG theory is underway at the Accelerator Test Facility (ATF) at Brookhaven National Laboratory (BNL) in collaboration with the Advanced Photon Source (APS) at Argonne National Laboratory (ANL). Using the above experiment's design parameters, the specific case of the harmonic output from the HGHG experiment will be examined using a 3D simulation code. The sensitivity of nonlinear harmonic output for this HGHG experiment as functions of emittance, energy spread, and peak current in both cases, and for the dispersive section strength and input seed power in the HGHG case, will be presented.

  7. High-gain direct-drive inertial confinement fusion for the Laser Megajoule: recent progress

    Canaud, B [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Garaude, F [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Ballereau, P [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Bourgade, J L [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Clique, C [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Dureau, D [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Houry, M [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Jaouen, S [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Jourdren, H [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Lecler, N [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Masse, L [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Masson, A [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Quach, R [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Piron, R [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Riz, D [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Vliet, J van der [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Temporal, M [Calle Grau, 685, Sucre (Bolivia); Delettrez, J A [Laboratory of Laser Energetics, University of Rochester, 250 East River Road, Rochester, NY 14623 (United States); McKenty, P W [Laboratory of Laser Energetics, University of Rochester, 250 East River Road, Rochester, NY 14623 (United States)

    2007-12-15

    Recent progress in high-gain direct-drive inertial confinement fusion with the laser Megajoule is reviewed. A new baseline direct-drive target design is presented which implodes with a two-cones irradiation pattern of indirect-drive beam configuration and zooming. Perturbation amplitudes and correlated growth rates of hydrodynamic instabilities in the compressed core of a directly driven inertial confinement fusion capsule are analyzed in planar and spherical geometries, with and without heat conduction, in the unsteady state regime of the deceleration. Shock propagation in heterogeneous media is addressed in the context of first shock. The neutron and photon emissions of high-gain direct-drive target are characterized. Numerical interpretations of directly driven homothetic cryogenic D{sub 2} target implosion experiments on the Omega facility are presented.

  8. Gain engineering for all-optical microwave and high speed pulse generation in mode-locked fiber lasers

    Li, Fangxin; Helmy, Amr S.

    2014-03-01

    Pulsed sources based on approaches that employ only photonic components and no RF components will be discussed in this talk. Several technologies have been explored to generate actively mode-locked sources using electronically driven fiber ring cavities. However, for these sources the pulse repetition rate is usually limited by the bandwidth of the intracavity modulator. Filtering of highly-stable low repetition rate optical combs utilizing cavities such as Fabry-Perot etalons can be used to overcome this limitation. This scheme is not flexible as it requires highly precise control of ultrahigh finesse etalons which limits the repetition rate to the free spectral range of the filter. Pulsed sources based on semiconductor devices offer many advantages, including large gain bandwidth, rapid tunability, long-term stability. In this work we introduce a novel, simple method to generate optical clock with wavelength tunability using two continuous wave (CW) lasers. The lasers are injected into a conventional SOAs-based fiber ring laser. The beating signal generated by these two lasers causes the modulation of the SOA gain saturation inside the cavity. Thus, the SOA provides gain and functions as the modulator as well as the gain medium. When the lasing mode inside the cavity is amplified, it also results in gain-induced four wave mixing. The proposed technique is particularly versatile, overcoming the bandwidth limitation of other techniques, which require RF sources. Moreover, this technique provides the possibility for hybrid integration as it is comprised of semiconductor chips that can be heterogeneously integrated on a Si platform.

  9. Effects of the pacifier activated lullaby on weight gain of premature infants.

    Cevasco, Andrea M; Grant, Roy E

    2005-01-01

    Within the past 5 years there has been an increase of premature infants surviving in the neonatal intensive care unit as well as an increasing cost for each day the infant is kept there. It is important for the premature infant to acquire the feeding skills necessary for weight gain, which lead to discharge from the hospital, and recent advancements have indicated the effectiveness in using contingent music to teach sucking skills to premature infants. The purpose of the first analysis in this study was to determine the effects of Pacifier Activated Lullaby (PAL) trials on weight gain of premature infants. During a 2-year time period, 62 infants from a sample of 188 met criteria for analysis. A one-way analysis of variance showed no significance in daily weight gain for the number of PAL trials completed. The mean weight gains for infants with 1 PAL trial = 13.85 grams, 2 trials = 26.67, 3 trials = 29.64, and 4 or more = 22.89. The Pearson product-moment correlation between the mean percent of music earned via nonnutritive sucking (NNS) and mean weight gain of all trials approached significance (p = .077, r = 0.18). In a second analysis, weight gained prior to use of PAL, during use of PAL, and post use of PAL was analyzed. Results indicated no significant difference between weight gain 1 day prior to use of PAL, the day of PAL trial, and 1 day post use of PAL. Mean weight gain for those infants who participated in 1 PAL trial was 8.49 grams for 1 day prior to use of PAL, 18.73 the day of PAL trial, and 24.81 for 1 day post use of PAL. Mean weight gain for 3 days prior to using the PAL was 10.78, 11.30 on the day of PAL trial, and 24.78 grams for 3 days post PAL use. The analyses show definite trends of greater weight gain with PAL use; however, individual variability within groups was greater than group differences leading to no significance in statistical analysis. In the third analysis the effect of proximity between premature infants' feeding schedule and PAL

  10. Olanzapine-high potency antipsychotic drug inducing significant weight gain: A case report

    Marić Nađa P.

    2008-01-01

    Full Text Available INTRODUCTION Olanzapine is a second generation antipsychotic (SGA with a high level of therapeutic effectiveness in schizophrenia and other psychotic disorders. Along with the positive therapeutic effects, an increase of the body weight frequently occurs. According to the literature, the average weight gain is about 6-7 kg during several months of treatment. This could be valued as a moderate weight increase. CASE OUTLINE This article presents a case of a young female with schizophrenia, without clinical improvement with several antipsychotics (clozapine, risperidone, haloperidol and with the occurrence of significant neurological side effects. The treatment started with olanzapine (baseline was associated with good initial response (PANSS reduction 20% in the first two weeks and the improvement was maintained further on (PANSS reduction 50% after 16 weeks. Significant increase (20 kg, 40% in weight appeared during the following 16 weeks (BMI at baseline 17.9 kg/m2; BMI 16 weeks later 25.1 kg/m2. CONCLUSION High effectiveness of olanzapine in schizophrenia symptoms reduction was accompanied by a significant weight gain. However, this drug leads to impaired glucoregulation, dyslipidaemia etc. It also increases the risk of diabetes and cardio-vascular diseases, i.e. the main causes of mortality in schizophrenia after a suicide. Therefore, clinicians are suggested to focus on possible predictors of weight gain during olanzapine therapy, and act accordingly in order to prevent serious health consequences.

  11. A Vehicle Haptic Steering by Wire System Based on High Gain GPI Observers

    A. Rodriguez-Angeles

    2014-01-01

    Full Text Available A vehicle steering by wire (SBW haptic system based on high gain generalized proportional integral (GPI observers is introduced. The observers are considered for the estimation of dynamic perturbations that are present at the tire and steering wheel. To ensure efficient tracking between the commanded steering wheel angle and the tire orientation angle, the estimated perturbations are on line canceled. As to provide a haptic interface with the driver, the estimated dynamic effects at the steering rack are fed back to the steering wheel, yielding a master-slave haptic system with bilateral communication. For implementation purposes few sensors and minimum knowledge of the dynamic model are required, which is a major advantage compared to other approaches. Only position tracking errors are fed back, while all other signals are estimated by the high gain GPI observers. The scheme is robust to uncertainty on the input gain and cancels dynamic perturbation effects such as friction and aligning forces on the tire. Experimental results are presented on a prototype platform.

  12. A bootstrapped, low-noise, and high-gain photodetector for shot noise measurement

    Zhou, Haijun; Yang, Wenhai; Li, Zhixiu; Li, Xuefeng; Zheng, Yaohui, E-mail: yhzheng@sxu.edu.cn [State Key Laboratory of Quantum Optics and Quantum Optics Devices, Institute of Opto-Electronics, Shanxi University, Taiyuan 030006 (China)

    2014-01-15

    We presented a low-noise, high-gain photodetector based on the bootstrap structure and the L-C (inductance and capacitance) combination. Electronic characteristics of the photodetector, including electronic noise, gain and frequency response, and dynamic range, were verified through a single-frequency Nd:YVO{sub 4} laser at 1064 nm with coherent output. The measured shot noise of 50 μW laser was 13 dB above the electronic noise at the analysis frequency of 2 MHz, and 10 dB at 3 MHz. And a maximum clearance of 28 dB at 2 MHz was achieved when 1.52 mW laser was illuminated. In addition, the photodetector showed excellent linearities for both DC and AC amplifications in the laser power range between 12.5 μW and 1.52 mW.

  13. Inkjet printing of novel wideband and high gain antennas on low-cost paper substrate

    Cook, Benjamin Stassen

    2012-09-01

    A complete characterization of the inkjet printing process using metallic nanoparticle inks on a paper substrate for microwave frequencies up to 12.5 GHz as well as its application to low-cost, high gain and wideband antenna design are demonstrated in this work. Laser and heat sintering of metallic nanoparticles are compared on paper substrate for the first time which demonstrate immense cost and time benefits of laser sintering. The antennas fabricated using the characterized process include a Vivaldi for the UWB band which exhibits a significantly higher gain of up to 8 dBi as compared to the currently published inkjet printed antennas, and a novel slow-wave log periodic dipole array which employs a new miniaturization technique to show 20% width reduction. © 1963-2012 IEEE.

  14. High-gain multipassed Yb:YAG amplifier for ultrashort pulse laser

    Vetrovec, John; Copeland, Drew A.; Litt, Amardeep S.; Du, Detao

    2016-05-01

    We report on a Yb:YAG laser amplifier for ultrashort pulse applications at kW-class average power. The laser uses two large-aperture, disk-type gain elements fabricated from composite ceramic YAG material, and a multi-pass extraction architecture to obtain high gain in a chirped-pulse amplification system. The disks are edge-pumped, thus allowing for reduced doping of the host material with laser ions, which translates to lower lasing threshold and lower heat dissipation in the Yb:YAG material. The latter makes it possible to amplify a near diffraction-limited seed without significant thermo-optical distortions. This work presents results of testing the laser amplifier with relay optics and passive polarization switching configured for energy extraction with up to 40 passes through the disks. Applications for the ultrashort pulse laser amplifier include producing a laser-induced plasma channel, laser material ablation, and laser acceleration of atomic particles.

  15. Interpolating gain-scheduled H∞ loop shaping design for high speed ball screw feed drives.

    Dong, Liang; Tang, WenCheng; Bao, DaFei

    2015-03-01

    This paper presents a method to design servo controllers for flexible ball screw drives with time-varying dynamics, which are mainly due to the time-varying table position and the workpiece mass. A gain-scheduled H∞ loop shaping controller is designed to achieve high tracking performance against the dynamic variations. H∞ loop shaping design procedure incorporates open loop shaping by a set of compensators to obtain performance/robust stability tradeoffs. The interpolating gain-scheduled controller is obtained by interpolating the state space model of the linear time-invariant (LTI) controllers estimated for fixed values of the scheduling parameters and a linear least squares problem can be solved. The proposed controller has been compared with P/PI with velocity and acceleration feedforward and adaptive backstepping sliding mode control experimentally. The experimental results indicate that the tracking performance has been improved and the robustness for time-varying dynamics has been achieved with the proposed scheme.

  16. High gain broadband amplification of ultraviolet pulses in optical parametric chirped pulse amplifier.

    Wnuk, Paweł; Stepanenko, Yuriy; Radzewicz, Czesław

    2010-04-12

    We report on a high gain amplification of broadband ultraviolet femtosecond pulses in an optical parametric chirped pulse amplifier. Broadband ultraviolet seed pulses were obtained by an achromatic frequency doubling of the output from a femtosecond Ti:Sapphire oscillator. Stretched seed pulses were amplified in a multipass parametric amplifier with a single BBO crystal pumped by a ns frequency quadrupled Nd:YAG laser. A noncollinear configuration was used for a broadband amplification. The total (after compression) amplification of 2.510(5) was achieved, with compressed pulse energy of 30 microJ and pulse duration of 24 fs. We found that the measured gain was limited by thermal effects induced by the absorption of the pump laser by color centers created in the BBO crystal.

  17. A bootstrapped, low-noise, and high-gain photodetector for shot noise measurement.

    Zhou, Haijun; Yang, Wenhai; Li, Zhixiu; Li, Xuefeng; Zheng, Yaohui

    2014-01-01

    We presented a low-noise, high-gain photodetector based on the bootstrap structure and the L-C (inductance and capacitance) combination. Electronic characteristics of the photodetector, including electronic noise, gain and frequency response, and dynamic range, were verified through a single-frequency Nd:YVO4 laser at 1064 nm with coherent output. The measured shot noise of 50 μW laser was 13 dB above the electronic noise at the analysis frequency of 2 MHz, and 10 dB at 3 MHz. And a maximum clearance of 28 dB at 2 MHz was achieved when 1.52 mW laser was illuminated. In addition, the photodetector showed excellent linearities for both DC and AC amplifications in the laser power range between 12.5 μW and 1.52 mW.

  18. Amplification of background EMG activity affects the interpretation of H-reflex gain.

    Tahayori, Behdad; Kitano, Koichi; Hong, Siang L; Koceja, David M

    2010-12-01

    In many H-reflex studies, the modulation of the H-reflex is usually compared relative to the normal EMG activity within the muscle. Such comparisons enable the investigators to infer whether the change in the amplitude of the H-reflex was independent of normally occurring muscle activity. This interpretation of the H-reflex is regarded as H-reflex gain, a popular dependent variable in human H-reflex studies. However, in many studies to date, the muscle activity level has been determined from the same EMG signal from which the H-reflex is recorded. This leads to an important methodological consideration: measuring the ongoing normal EMG activity from the same signal might result in an inaccurate measurement, since this EMG signal will need to be minimally amplified to capture the synchronous volley of the H-reflex amplitude. In this study we examined this possibility and found that comparing the EMG activity level from the seated position to standing position yields different results (on average 8.03% in the measurement of the increase of muscle activity). This difference was both dependent on the task and also on the EMG instrumentation used. To solve this problem we suggest the bifurcation of the EMG signal from the recording electrodes with differential amplification of the signal. With this method, both the naturally occurring muscle activity and the H-reflex signal are collected from the same area of the muscle and a more accurate measurement of the H-reflex gain will be yielded.

  19. Modeling and Analysis of Transformerless High Gain Buck-boost DC-DC Converters

    Vu Tran

    2014-12-01

    Full Text Available This paper proposes a transfomerless switched capacitor buck boost converter model, which provides higher voltage gain and higher efficiency when compared to the conventional buck boost converter. The averaged model based on state-space description is analyzed in the paper. The simulation results are presented to confirm the capability of the converter to generate high voltage ratios. The comparison between the proposed model and the traditional model is also provided to reveal the improvement. The proposed converter is suitable for for a wide application which requires high step-up DC-DC converters such as DC micro-grids and solar electrical energy.

  20. Design of High Gain and Broadband Antennas at 60 GHz for Underground Communications Systems

    Yacouba Coulibaly

    2012-01-01

    Full Text Available A new broadband and high gain dielectric resonator antenna for millimeter wave is presented. The investigated antenna configuration consists of a periodic square ring frequency selective surfaces on a superstrate, an aperture-coupled scheme feed, an intermediate substrate, and a cylindrical dielectric resonator. This antenna is designed to cover the ISM frequency band at 60 GHz (57 GHz–64 GHz. It was numerically designed using CST microwave Studio simulation software package. Another prototype with a plain dielectric superstrate is also studied for comparison purposes. A bandwidth of 13.56% at the centered frequency of 61.34 GHz and a gain of 11 dB over the entire ISM band have been achieved. A maximum gain of 14.26 dB is obtained at 60 GHz. This is an enhancement of 9 dB compared to a single DRA. HFSS is used to validate our antenna designs. Good agreement between the results of the two softwares is obtained. With these performances, these antennas promise to be useful in the design of future wireless underground communication systems operating in the unlicensed 60 GHz frequency band.

  1. Broadband microwave phase shifter based on high speed cross gain modulation in quantum dot semiconductor optical amplifiers

    Chen, Yaohui; Mørk, Jesper

    2009-01-01

    We present a scheme to achieve tunable ~180 degrees microwave phase shifts at frequencies exceeding 100 GHz based on high speed cross gain modulation in quantum dot semiconductor optical amplifiers.......We present a scheme to achieve tunable ~180 degrees microwave phase shifts at frequencies exceeding 100 GHz based on high speed cross gain modulation in quantum dot semiconductor optical amplifiers....

  2. Whey protein reduces early life weight gain in mice fed a high-fat diet.

    Britt Tranberg

    Full Text Available An increasing number of studies indicate that dairy products, including whey protein, alleviate several disorders of the metabolic syndrome. Here, we investigated the effects of whey protein isolate (whey in mice fed a high-fat diet hypothesising that the metabolic effects of whey would be associated with changes in the gut microbiota composition. Five-week-old male C57BL/6 mice were fed a high-fat diet ad libitum for 14 weeks with the protein source being either whey or casein. Faeces were collected at week 0, 7, and 13 and the fecal microbiota was analysed by denaturing gradient gel electrophoresis analyses of PCR-derived 16S rRNA gene (V3-region amplicons. At the end of the study, plasma samples were collected and assayed for glucose, insulin and lipids. Whey significantly reduced body weight gain during the first four weeks of the study compared with casein (P<0.001-0.05. Hereafter weight gain was similar resulting in a 15% lower final body weight in the whey group relative to casein (34.0±1.0 g vs. 40.2±1.3 g, P<0.001. Food intake was unaffected by protein source throughout the study period. Fasting insulin was lower in the whey group (P<0.01 and glucose clearance was improved after an oral glucose challenge (P<0.05. Plasma cholesterol was lowered by whey compared to casein (P<0.001. The composition of the fecal microbiota differed between high- and low-fat groups at 13 weeks (P<0.05 whereas no difference was seen between whey and casein. In conclusion, whey initially reduced weight gain in young C57BL/6 mice fed a high-fat diet compared to casein. Although the effect on weight gain ceased, whey alleviated glucose intolerance, improved insulin sensitivity and reduced plasma cholesterol. These findings could not be explained by changes in food intake or gut microbiota composition. Further studies are needed to clarify the mechanisms behind the metabolic effects of whey.

  3. High Gain Antenna System Deployment Mechanism Integration, Characterization, and Lessons Learned

    Parong, Fil; Russell, Blair; Garcen, Walter; Rose, Chris; Johnson, Chris; Huber, Craig

    2014-01-01

    The integration and deployment testing of the High Gain Antenna System for the Global Precipitation Measurement mission is summarized. The HGAS deployment mechanism is described. The gravity negation system configuration and its influence on vertical, ground-based, deployment tests are presented with test data and model predictions. A focus is made on the late discovery and resolution of a potentially mission degrading deployment interference condition. The interaction of the flight deployment mechanism, gravity negation mechanism, and use of dynamic modeling is described and lessons learned presented.

  4. Photosynthetically active radiation and carbon gain drives the southern orientation of Myrtillocactus geometrizans fruits.

    Ponce-Bautista, A; Valverde, P L; Flores, J; Zavala-Hurtado, A; Vite, F; López-Ortega, G; Pérez-Hernández, M A

    2017-03-01

    The equatorial orientation of reproductive structures is known in some columnar cacti from extratropical deserts. It has been hypothesised that photosynthetically active radiation (PAR) interception is the main reason for this orientation, because of its key effect on nocturnal CO2 uptake. However, there are no studies addressing both the effect of PAR and its consequence, carbon gain, on fruit orientation. Accordingly, we tested whether PAR and carbon gain could explain the southern fruit orientation of Myrtillocactus geometrizans, an inter-tropical columnar cactus. We studied three populations of M. geometrizans in Mexico. For each population, azimuth of fruits, total daily PAR, nocturnal acid accumulation (NAA) and fruit production were measured. The relationships between rib orientation and number of fruits, as well as total daily PAR, were evaluated using periodic regressions. The effect of total daily PAR and NAA on number of fruits was assessed using generalised linear models. During spring, mean fruit orientation had a south azimuth for three populations. Likewise, rib orientation had a significant effect on fruit production, with the south-facing ribs having the maximum number of fruits. Total daily PAR was highest in the south-facing ribs, at least for those in the northern and central populations. Furthermore, during spring, there was a significant positive effect of total daily PAR and NAA on fruit production. Our results provide strong evidence that the higher carbon gain in equatorial ribs, through a highest interception of PAR, would be the responsible factor for equatorial orientation of fruits in an inter-tropical columnar cactus.

  5. The activity in the contralateral primary motor cortex, dorsal premotor and supplementary motor area is modulated by performance gains

    Ronen eSosnik

    2014-04-01

    Full Text Available There is growing experimental evidence that the engagement of different brain areas in a given motor task may change with practice, although the specific brain activity patterns underlying different stages of learning, as defined by kinematic or dynamic performance indices, are not well understood. Here we studied the change in activation in motor areas during practice on sequences of handwriting-like trajectories, connecting four target points on a digitizing table 'as rapidly and as accurately as possible' while lying inside an fMRI scanner. Analysis of the subjects' pooled kinematic and imaging data, acquired at the beginning, middle and end of the training period, revealed no correlation between the amount of activation in the contralateral M1, PM (dorsal and ventral, SMA, preSMA and PPC and the amount of practice per-se. Single trial analysis has revealed that the correlation between the amount of activation in the contralateral M1 and trial mean velocity was partially modulated by performance gains related effects, such as increased hand motion smoothness. Furthermore, it was found that the amount of activation in the contralateral preSMA increased when subjects shifted from generating straight point-to-point trajectories to their spatiotemporal concatenation into a smooth, curved trajectory. Altogether, our results indicate that the amount of activation in the contralateral M1, PMd and preSMA during the learning of movement sequences is correlated with performance gains and that high level motion features (e.g., motion smoothness may modulate, or even mask correlations between activity changes and low-level motion attributes (e.g., trial mean velocity.

  6. Polarization beam combination technique for gain saturation effect compensation in high-energy systems

    Chen, Junchi; Peng, Yujie; Su, Hongpeng; Leng, Yuxin

    2016-06-01

    To compensate for the gain saturation effect in the high-energy laser amplifier, a modified polarization beam combination (PBC) method is introduced to reshape temporal waveform of the injected laser pulse to obtain a controlled high-energy laser pulse shape after amplification. One linearly polarized beam is divided into two orthogonal polarized beams, which spatially recombine together collinearly after propagating different optical paths with relative time delay in PBC structure. The obtained beam with polarization direction being rotated by the following half wave plate is divided and combined again to reform a new beam in another modified polarization beam structure. The reformed beam is injected into three cascaded laser amplifiers. The amplified pulse shape can be controlled by the incident pulse shape and amplifier gain, which is agreeable to the simulation by the Frank-Nodvik equations. Based on the simple method, the various temporal waveform of output pulse with tunable 7 to 20 ns pulse duration can be obtained without interferometric fringes.

  7. Monopole Charge Domain in High-Gain Gallium Arsenide Photoconductive Switches

    施卫; 陈二柱; 张显斌; 李琦

    2002-01-01

    Considering that semi-insulating gallium arsenide photoconductive switches can be triggered into the high gain mode and no reliable theories can account for the observed transient characteristics, we propose the monopole charge domain model to explain the peculiar switching phenomena occurring in the high gain mode and we discuss the requirements for the lock-on switching. During operation on this mode, the applied field across the switch and the lock-on field are all larger than the Gunn threshold field. Our developed monopole charge domain is based on the transferred-electron effect, but the domain is only composed of large numbers of electrons piled up due to the negative differential mobility. Using the model and taking the physical mechanism of the avalanche impact ionization and recombination radiation into consideration, we interpret the typical phenomena of the lock-on effect, such as the time delay between the beginning of optical illumination and turning-on of the switch, and the conduction mechanism of the sustaining phase. Under different conditions of bias field intensity and incident light energy, the time delay of the switching is calculated. The results show that the physical mechanisms of impact ionization and recombination radiation occurring in the monopole charge domain are responsible for the lock-on switching.

  8. DFIG-Based Wind Turbine Robust Control Using High-Order Sliding Modes and a High Gain Observer

    Beltran, Brice; Benbouzid, Mohamed; Ahmed-Ali, Tarek; Mangel, Hervé

    2011-01-01

    International audience; This paper deals with the power generation control in variable speed wind turbines. In this context, a control strategy is proposed to ensure power extraction optimization of a DFIG-based wind turbine. The proposed control strategy combines an MPPT using a high gain observer and second-order sliding mode for the DFIG control. This strategy presents attractive features such as chattering-free behavior, finite reaching time, robustness and unmodeled dynamics (generator a...

  9. Indirect flat-panel detector with avalanche gain: fundamental feasibility investigation for SHARP-AMFPI (scintillator HARP active matrix flat panel imager).

    Zhao, Wei; Li, Dan; Reznik, Alla; Lui, B J M; Hunt, D C; Rowlands, J A; Ohkawa, Yuji; Tanioka, Kenkichi

    2005-09-01

    An indirect flat-panel imager (FPI) with avalanche gain is being investigated for low-dose x-ray imaging. It is made by optically coupling a structured x-ray scintillator CsI(Tl) to an amorphous selenium (a-Se) avalanche photoconductor called HARP (high-gain avalanche rushing photoconductor). The final electronic image is read out using an active matrix array of thin film transistors (TFT). We call the proposed detector SHARP-AMFPI (scintillator HARP active matrix flat panel imager). The advantage of the SHARP-AMFPI is its programmable gain, which can be turned on during low dose fluoroscopy to overcome electronic noise, and turned off during high dose radiography to avoid pixel saturation. The purpose of this paper is to investigate the important design considerations for SHARP-AMFPI such as avalanche gain, which depends on both the thickness d(Se) and the applied electric field E(Se) of the HARP layer. To determine the optimal design parameter and operational conditions for HARP, we measured the E(Se) dependence of both avalanche gain and optical quantum efficiency of an 8 microm HARP layer. The results were used in a physical model of HARP as well as a linear cascaded model of the FPI to determine the following x-ray imaging properties in both the avalanche and nonavalanche modes as a function of E(Se): (1) total gain (which is the product of avalanche gain and optical quantum efficiency); (2) linearity; (3) dynamic range; (4) gain nonuniformity resulting from thickness nonuniformity; and (5) effects of direct x-ray interaction in HARP. Our results showed that a HARP layer thickness of 8 microm can provide adequate avalanche gain and sufficient dynamic range for x-ray imaging applications to permit quantum limited operation over the range of exposures needed for radiography and fluoroscopy.

  10. Redesign of a Variable-Gain Output Feedback Longitudinal Controller Flown on the High-Alpha Research Vehicle (HARV)

    Ostroff, Aaron J.

    1998-01-01

    This paper describes a redesigned longitudinal controller that flew on the High-Alpha Research Vehicle (HARV) during calendar years (CY) 1995 and 1996. Linear models are developed for both the modified controller and a baseline controller that was flown in CY 1994. The modified controller was developed with three gain sets for flight evaluation, and several linear analysis results are shown comparing the gain sets. A Neal-Smith flying qualities analysis shows that performance for the low- and medium-gain sets is near the level 1 boundary, depending upon the bandwidth assumed, whereas the high-gain set indicates a sensitivity problem. A newly developed high-alpha Bode envelope criterion indicates that the control system gains may be slightly high, even for the low-gain set. A large motion-base simulator in the United Kingdom was used to evaluate the various controllers. Desired performance, which appeared to be satisfactory for flight, was generally met with both the low- and medium-gain sets. Both the high-gain set and the baseline controller were very sensitive, and it was easy to generate pilot-induced oscillation (PIO) in some of the target-tracking maneuvers. Flight target-tracking results varied from level 1 to level 3 and from no sensitivity to PIO. These results were related to pilot technique and whether actuator rate saturation was encountered.

  11. Whey protein reduces early life weight gain in mice fed a high-fat diet

    Tranberg, Britt; Hellgren, Lars; Lykkesfeldt, Jens

    2013-01-01

    An increasing number of studies indicate that dairy products, including whey protein, alleviate several disorders of the metabolic syndrome. Here, we investigated the effects of whey protein isolate (whey) in mice fed a high-fat diet hypothesising that the metabolic effects of whey would...... be associated with changes in the gut microbiota composition. Five-week-old male C57BL/6 mice were fed a high-fat diet ad libitum for 14 weeks with the protein source being either whey or casein. Faeces were collected at week 0, 7, and 13 and the fecal microbiota was analysed by denaturing gradient gel...... weight gain was similar resulting in a 15% lower final body weight in the whey group relative to casein (34.0±1.0 g vs. 40.2±1.3 g, Pprotein source throughout the study period. Fasting insulin was lower in the whey group (P

  12. High Gain Slot Array with Fabry-Perot Cavity Feeding Circuit

    Halim Boutayeb

    2016-01-01

    Full Text Available A new approach for designing slot arrays using a Fabry-Perot cavity for the feeding circuit is presented. The proposed array has simpler and smaller feeding circuit compared to conventional feeding networks that have multiple dividers or combiners. The dividers and combiners are usually sources of losses. In addition, the profile of the proposed array is not limited by the half-wavelength resonance condition that exists for Fabry-Perot resonator antennas based on partially reflecting surfaces. The operating frequency is not sensitive to the profile of the antenna. A small profile can be achieved without the utilization of an artificial magnetic conductor or a substrate with high dielectric constant. To validate the proposed approach, full-wave numerical results are presented at 5.8 GHz showing good impedance matching, a high gain of about 22 dB, and an efficiency of 76%.

  13. Whey protein reduces early life weight gain in mice fed a high-fat diet

    Tranberg, Britt; Hellgren, Lars; Lykkesfeldt, Jens;

    2013-01-01

    be associated with changes in the gut microbiota composition. Five-week-old male C57BL/6 mice were fed a high-fat diet ad libitum for 14 weeks with the protein source being either whey or casein. Faeces were collected at week 0, 7, and 13 and the fecal microbiota was analysed by denaturing gradient gel...... weight gain was similar resulting in a 15% lower final body weight in the whey group relative to casein (34.0±1.0 g vs. 40.2±1.3 g, PFasting insulin was lower in the whey group (P... after an oral glucose challenge (Pmicrobiota differed between high- and low-fat groups at 13 weeks (P

  14. Millimeter-wave double-dipole antennas for high-gain integrated reflector illumination

    Filipovic, Daniel F.; Ali-Ahmad, Walid Y.; Rebeiz, Gabriel M.

    1992-05-01

    A double-dipole antenna backed by a ground plane has been fabricated for submillimeter wavelengths. The double-dipole antenna is integrated on a thin dielectric membrane with a planar detector at its center. Measured feed patterns at 246 GHz agree well with theory and demonstrate a rotationally symmetric pattern with high coupling efficiency to Gaussian beams. The input impedance is around 50 ohms, and will match well to a Schottky diode or SIS detector. The double-dipole antenna served as the feed for a small machined parabolic reflector. The integrated reflector had a measured gain of 37 dB at 119 microns. This makes the double-dipole antenna ideally suited as a feed for high resolution tracking or for long focal length Cassegrain antenna systems.

  15. Lossless Airy Surface Polaritons in a Metamaterial via Active Raman Gain

    Zhang, Qi; Huang, Guoxiang

    2016-01-01

    We propose a scheme to realize a lossless propagation of linear and nonlinear Airy surface polaritons (SPs) via active Raman gain (ARG). The system we suggest is a planar interface superposed by a negative index metamaterial (NIMM) and a dielectric, where three-level quantum emitters are doped. By using the ARG from the quantum emitters and the destructive interference effect between the electric and magnetic responses from the NIMM, we show that not only the Ohmic loss of the NIMM but also the light absorption of the quantum emitters can be completely eliminated. As a result, non-diffractive Airy SPs may propagate for very long distance without attenuation. We also show that the Kerr nonlinearity of the system can be largely enhanced due to the introduction of the quantum emitters and hence lossless Airy surface polaritonic solitons with very low power can be generated in the system.

  16. Storage and retrieval of light pulses in a fast-light medium via active Raman gain

    Xu, Datang; Bai, Zhengyang; Huang, Guoxiang

    2016-12-01

    We propose a scheme to realize the storage and retrieval of light pulses in a fast-light medium via a mechanism of active Raman gain (ARG). The system under consideration is a four-level atomic gas interacting with three (pump, signal, and control) laser fields. We show that a stable propagation of signal light pulses with superluminal velocity (i.e., fast-light pulses) is possible in such a system through the ARG contributed by the pump field and the quantum interference effect induced by the control field. We further show that a robust storage and retrieval of light pulses in such a fast-light medium can be implemented by switching on and off the pump and the control fields simultaneously. The results reported here may have potential applications for light information processing and transmission using fast-light media.

  17. High-pass filtering and dynamic gain regulation enhance vertical bursts transmission along the mossy fiber pathway of cerebellum

    Jonathan Mapelli

    2010-05-01

    Full Text Available Signal elaboration in the cerebellum mossy fiber input pathway presents controversial aspects, especially concerning gain regulation and the spot-like (rather than beam-like appearance of granular-to-molecular layer transmission. By using voltage-sensitive dye (VSD imaging in rat cerebellar slices (Mapelli et al., 2010, we found that mossy fiber bursts optimally excited the granular layer above ~50 Hz and the overlaying molecular layer above ~100 Hz, thus generating a cascade of high-pass filters. NMDA receptors enhanced transmission in the granular, while GABA-A receptors depressed transmission in both the granular and molecular layer. Burst transmission gain was controlled through a dynamic frequency-dependent involvement of these receptors. Moreover, while high-frequency transmission was enhanced along vertical lines connecting the granular to molecular layer, no high-frequency enhancement was observed along the parallel fiber axis in the molecular layer. This was probably due to the stronger effect of Purkinje cell GABA-A receptor-mediated inhibition occurring along the parallel fibers than along the granule cell axon ascending branch. The consequent amplification of burst responses along vertical transmission lines could explain the spot-like activation of Purkinje cells observed following punctuate stimulation in vivo .

  18. Actively phase-controlled coupling between plasmonic waveguides via in-between gain-assisted nanoresonator: nanoscale optical logic gates.

    Ho, Kum-Song; Han, Yong-Ha; Ri, Chol-Song; Im, Song-Jin

    2016-08-15

    The development of nanoscale optical logic gates has attracted immense attention due to increasing demand for ultrahigh-speed and energy-efficient optical computing and data processing, however, suffers from the difficulty in precise control of phase difference of the two optical signals. We propose a novel conception of nanoscale optical logic gates based on actively phase-controlled coupling between two plasmonic waveguides via an in-between gain-assisted nanoresonator. Precise control of phase difference between the two plasmonic signals can be performed by manipulating pumping rate at an appropriate frequency detuning, enabling a high contrast between the output logic states "1" and "0." Without modification of the structural parameters, different logic functions can be provided. This active nanoscale optical logic device is expected to be quite energy-efficient with ideally low energy consumption on the order of 0.1 fJ/bit. Analytical calculations and numerical experiments demonstrate the validity of the proposed concept.

  19. Progress in laboratory high gain ICF (inertial confinement fusion): Prospects for the future

    Storm, E.; Lindl, J.D.; Campbell, E.M.; Bernat, T.P.; Coleman, L.W.; Emmett, J.L.; Hogan, W.J.; Hunt, J.T.; Krupke, W.F.; Lowdermilk, W.H.

    1988-01-01

    Inertial confinement fusion (ICF), a thermonuclear reaction in a small (/approximately/5 mm diameter) fuel capsule filled with a few milligrams of deuterium and tritium, has been the subject of very fruitful experimentation since the early 1970's. High gain ICF is now on the threshold of practical applications. With a Laboratory Microfusion Facility (LMF), these applications will have major implications for national defense, basic and applied science, and power production. With a driver capable of delivering about 10 MJ in a 10-ns pulse at an intensity of /approximately/3 /times/ 10/sup 14/ W/cm/sup 2/, an appropriately configured cryogenic capsule could be compressed to a density of about 200 g/cm/sup 3/ and a temperature of 3--5 keV. Under these conditions, up to 10 mg of DT could be ignited, and with a burn efficiency of about 30%, release up to 1000 MJ of fusion energy, an energy gain of about 100. A thousand megajoules is equivalent to about one quarter ton of TNT, or about 7 gallons of oil--an amount of energy tractable under laboratory conditions and potentially very useful for a variety of applications. 61 refs., 33 figs.

  20. Small sized high-gain PHEMT high-power amplifiers for X-band applications

    Hek, A.P. de; Hunneman, P.A.H.

    2000-01-01

    The development of two small sized broadband X-band high-power amplifiers is discussed. The amplifiers are realised with the help of the pseudomorphic HEMT technology of the Fraunhofer Institute for Applied Solid State Physics (FhG-IAF). With the help of this technology the feasibility of integratin

  1. High-gain Seeded FEL Amplifier Tunable in the Terahertz Range

    Sung, C; Pellegrini, C; Ralph, J E; Reiche, S; Rosenzweig, J B; Tochitsky, Sergei Ya

    2005-01-01

    The lack of a high-power, relatively low-cost and compact terahertz (THz) source in the range 0.3-3x10(12) Hz is the major obstacle in progressing on biomedical and material studies at these wavelengths. A high-gain, single pass seeded FEL technique allows to obtain high power THz pulses of a high spectral brightness. We describe an ongoing project at the Neptune laboratory where a ~ 1kW seed pulse generated by difference frequency mixing of CO2 laser lines in a GaAs nonlinear crystal is injected into a waveguide FEL amplifier. The FEL is driven by a 5 ps (r.m.s) long electron pulse with a peak current up to 100A provided by a regular S-band photoinjector. According to 3-D, time dependent simulations, up to ~ 10 MW THz power can be generated using a 2 meter long planar undulator. By mixing different pairs of CO2 laser lines and matching resonant energy of the electron beam, tunability in the 100-400 mm range is expected. A tunable Fabri-Perot interferometer will be used to select a high-power 5ps THz pulse. T...

  2. Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice

    Madsen, Birgitte Lindegaard; Matthews, Vance B; Brandt, Claus

    2013-01-01

    Circulating interleukin (IL)-18 is elevated in obesity, but paradoxically causes hypophagia. We hypothesized that IL-18 may attenuate high fat diet induced insulin resistance by activating AMP activated protein kinase (AMPK). We studied mice with a global deletion of the α isoform of the IL-18...

  3. CLOSED LOOP CONTROL OF THREE PORT CONVERTER WITH HIGH VOLTAGE GAIN

    Santhi Mary Antony A

    2015-08-01

    Full Text Available Photovoltaic (PV system is one of the best renewable energy sources for power generation system due to their pollution free and low cost properties. The PV cells has less efficiency compared to other source of power generation. The system efficiency is improved by reducing components count, which reduces the losses. In this paper a new three port converter (TPC is proposed for stand-alone renewable power applications. The proposed converter has three switches to achieve the power flow control. Single inductor is used for common energy transfer element for two different sources. The coupled inductor is used to increase the voltage conversion ratio with reasonable duty cycle. Thus the proposed converter has high voltage gain with less components count. The output voltage is regulated through feedback network. The system performance is verified through simulation results.

  4. Photovoltaic Response Characteristics of GaAs Photoconductive Switches Under High Gain Mode

    DAI Hui-ying; SHI Wei

    2007-01-01

    Given is the experiment results in which the laser pulses of 1 046 nm and 532 nm are used to trigger the semi-insulation GaAs photoconductive semiconductor switch(PCSS) with an electrode distance of 4 mm. And made is an analysis of the switch's photovoltaic response characteristics under the high gain mode when the biased field is bigger than the Geng effect field. Also a theory is presented that the main reason for the photovoltaic pulse response delay is the transmission of charge domain, caused by the presence of EL2 energy level in the chip material. Finally, the transmission time of charge domain is calculated and a result that inosculates with the experiment is attained.

  5. A high gain patch fed horn antenna for millimeter wave imaging receiver

    Shireen, Rownak; Hwang, Timothy; Shi, Shouyuan; Prather, D. W.

    2005-11-01

    In this paper, antennas that combine transitions from microstrip line / coplanar waveguide (CPW) to horn antenna in a single unit are presented. Conventional single layer microstrip patch antennas inherently suffer narrow operation bandwidth; to widen the frequency bandwidth, stacked patch antennas are used and high gain is achieved from the horn antenna. Here, microstrip line / CPW directly feeds the bottom patch while the top patch couples parasitically to the bottom patch. For -10 dB return loss, 25% bandwidth is achieved for both microstrip line to horn antenna (MSLTHA) at center frequency f0=17.5 GHz and for CPW to horn antenna (CPWTHA) at f0=97 GHz. The designs were optimized using 3D Finite Element Method (FEM) software HFSS by Ansoft Corporation. The optimal design of MSLTHA has been fabricated and characterized. The return loss and far field radiation pattern are measured and has been found in very good agreement with the simulation results.

  6. Convergent Evolution towards High Net Carbon Gain Efficiency Contributes to the Shade Tolerance of Palms (Arecaceae).

    Ma, Ren-Yi; Zhang, Jiao-Lin; Cavaleri, Molly A; Sterck, Frank; Strijk, Joeri S; Cao, Kun-Fang

    2015-01-01

    Most palm species occur in the shaded lower strata of tropical rain forests, but how their traits relate to shade adaptation is poorly understood. We hypothesized that palms are adapted to the shade of their native habitats by convergent evolution towards high net carbon gain efficiency (CGEn), which is given by the maximum photosynthetic rate to dark respiration rate ratio. Leaf mass per area, maximum photosynthetic rate, dark respiration and N and P concentrations were measured in 80 palm species grown in a common garden, and combined with data of 30 palm species growing in their native habitats. Compared to other species from the global leaf economics data, dicotyledonous broad-leaved trees in tropical rainforest or other monocots in the global leaf economics data, palms possessed consistently higher CGEn, achieved by lowered dark respiration and fairly high foliar P concentration. Combined phylogenetic analyses of evolutionary signal and trait evolution revealed convergent evolution towards high CGEn in palms. We conclude that high CGEn is an evolutionary strategy that enables palms to better adapt to shady environments than coexisting dicot tree species, and may convey advantages in competing with them in the tropical forest understory. These findings provide important insights for understanding the evolution and ecology of palms, and for understanding plant shade adaptations of lower rainforest strata. Moreover, given the dominant role of palms in tropical forests, these findings are important for modelling carbon and nutrient cycling in tropical forest ecosystems.

  7. Convergent Evolution towards High Net Carbon Gain Efficiency Contributes to the Shade Tolerance of Palms (Arecaceae.

    Ren-Yi Ma

    Full Text Available Most palm species occur in the shaded lower strata of tropical rain forests, but how their traits relate to shade adaptation is poorly understood. We hypothesized that palms are adapted to the shade of their native habitats by convergent evolution towards high net carbon gain efficiency (CGEn, which is given by the maximum photosynthetic rate to dark respiration rate ratio. Leaf mass per area, maximum photosynthetic rate, dark respiration and N and P concentrations were measured in 80 palm species grown in a common garden, and combined with data of 30 palm species growing in their native habitats. Compared to other species from the global leaf economics data, dicotyledonous broad-leaved trees in tropical rainforest or other monocots in the global leaf economics data, palms possessed consistently higher CGEn, achieved by lowered dark respiration and fairly high foliar P concentration. Combined phylogenetic analyses of evolutionary signal and trait evolution revealed convergent evolution towards high CGEn in palms. We conclude that high CGEn is an evolutionary strategy that enables palms to better adapt to shady environments than coexisting dicot tree species, and may convey advantages in competing with them in the tropical forest understory. These findings provide important insights for understanding the evolution and ecology of palms, and for understanding plant shade adaptations of lower rainforest strata. Moreover, given the dominant role of palms in tropical forests, these findings are important for modelling carbon and nutrient cycling in tropical forest ecosystems.

  8. A High Efficiency Variable Gain Amplifier Circuit with Controllable Transconductance Amp

    Okura, Tetsuro; Okura, Shunsuke; Ido, Toru; Taniguchi, Kenji

    A novel power reduction technique for a variable gain amplifier (VGA) with a two-stage operational amplifier is proposed. The technique improves the power consumption of a VGA by optimizing the bandwidth and the phase margin dynamically on all gain range of the VGA through controlling the input transconductance of opamp. A VGA utilizing the proposed technique shows 40% reduction of power consumption against a conventional VGA at the best condition of VGA gain range.

  9. Fluorene- and benzofluorene-cored oligomers as low threshold and high gain amplifying media

    Kazlauskas, Karolis, E-mail: karolis.kazlauskas@ff.vu.lt; Kreiza, Gediminas; Bobrovas, Olegas; Adomėnienė, Ona; Adomėnas, Povilas; Juršėnas, Saulius [Institute of Applied Research, Vilnius University, Saulėtekio 9-III, LT-10222 Vilnius (Lithuania); Jankauskas, Vygintas [Department of Solid State Electronics, Vilnius University, Saulėtekio 9-III, LT-10222 Vilnius (Lithuania)

    2015-07-27

    Deliberate control of intermolecular interactions in fluorene- and benzofluorene-cored oligomers was attempted via introduction of different-length alkyl moieties to attain high emission amplification and low amplified spontaneous emission (ASE) threshold at high oligomer concentrations. Containing fluorenyl peripheral groups decorated with different-length alkyl moieties, the oligomers were found to express weak concentration quenching of emission, yet excellent carrier drift mobilities (close to 10{sup −2} cm{sup 2}/V/s) in the amorphous films. Owing to the larger radiative decay rates (>1.0 × 10{sup 9 }s{sup −1}) and smaller concentration quenching, fluorene-cored oligomers exhibited down to one order of magnitude lower ASE thresholds at higher concentrations as compared to those of benzofluorene counterparts. The lowest threshold (300 W/cm{sup 2}) obtained for the fluorene-cored oligomers at the concentration of 50 wt % in polymer matrix is among the lowest reported for solution-processed amorphous films in ambient conditions, what makes the oligomers promising for lasing application. Great potential in emission amplification was confirmed by high maximum net gain (77 cm{sup −1}) revealed for these compounds. Although the photostability of the oligomers was affected by photo-oxidation, it was found to be comparable to that of various organic lasing materials including some commercial laser dyes evaluated under similar excitation conditions.

  10. Relationship between sociodemographics, dietary intake, and physical activity with gestational weight gain among pregnant women in Rafsanjan City, Iran.

    Ebrahimi, Fatemeh; Shariff, Zalilah Mohd; Tabatabaei, Seyed Zia; Fathollahi, Mahmood Sheikh; Mun, Chan Yoke; Nazari, Mozhgan

    2015-03-01

    Gestational weight gain (GWG) is a determinant of health and nutrition of mothers and offspring. However, many factors associated with GWG are not completely understood. The present study assessed the relationship between sociodemographics, dietary intake, and physical activity with GWG in 308 Iranian pregnant women attending government healthcare centres in Rafsanjan city, Iran. Women gained an average of 12.87±3.57 kg during pregnancy while 54% did not gain weight within the Institute of Medicine (IOM)-recommended range. Univariate logistic models showed that gestaional weight gain was related to age, pre-pregnancy body mass index (BMI), energy intake, and sitting time. Cumulative logit model showed positive relationship between age (p=0.0137) and pre-pregnancy BMI (pnutritional status and physical activity should be emphasized in antenatal care.

  11. Gestational weight gain by reduced brain melanocortin activity affects offspring energy balance in rats

    Heinsbroek, A. C. M.; van Dijk, G.

    2009-01-01

    Introduction: Excessive gestational body weight gain of mothers may predispose offspring towards obesity and metabolic derangements. It is difficult to discern the effects of maternal obesogenic factors-such as diet and/or thrifty genetic predisposition-from gestational weight gain per se. Methods:

  12. A scalable-low cost architecture for high gain beamforming antennas

    Bakr, Omar

    2010-10-01

    Many state-of-the-art wireless systems, such as long distance mesh networks and high bandwidth networks using mm-wave frequencies, require high gain antennas to overcome adverse channel conditions. These networks could be greatly aided by adaptive beamforming antenna arrays, which can significantly simplify the installation and maintenance costs (e.g., by enabling automatic beam alignment). However, building large, low cost beamforming arrays is very complicated. In this paper, we examine the main challenges presented by large arrays, starting from electromagnetic and antenna design and proceeding to the signal processing and algorithms domain. We propose 3-dimensional antenna structures and hybrid RF/digital radio architectures that can significantly reduce the complexity and improve the power efficiency of adaptive array systems. We also present signal processing techniques based on adaptive filtering methods that enhance the robustness of these architectures. Finally, we present computationally efficient vector quantization techniques that significantly improve the interference cancellation capabilities of analog beamforming architectures. © 2010 IEEE.

  13. Transportation-cyber-physical-systems-oriented engine cylinder pressure estimation using high gain observer

    Li, Yong-Fu; Xiao-Pei, Kou; Zheng, Tai-Xiong; Li, Yin-Guo

    2015-05-01

    In transportation cyber-physical-systems (T-CPS), vehicle-to-vehicle (V2V) communications play an important role in the coordination between individual vehicles as well as between vehicles and the roadside infrastructures, and engine cylinder pressure is significant for engine diagnosis on-line and torque control within the information exchange process under V2V communications. However, the parametric uncertainties caused from measurement noise in T-CPS lead to the dynamic performance deterioration of the engine cylinder pressure estimation. Considering the high accuracy requirement under V2V communications, a high gain observer based on the engine dynamic model is designed to improve the accuracy of pressure estimation. Then, the analyses about convergence, converge speed and stability of the corresponding error model are conducted using the Laplace and Lyapunov method. Finally, results from combination of Simulink with GT-Power based numerical experiments and comparisons demonstrate the effectiveness of the proposed approach with respect to robustness and accuracy. Project supported by the National Natural Science Foundation of China (Grant No. 61304197), the Scientific and Technological Talents of Chongqing, China (Grant No. cstc2014kjrc-qnrc30002), the Key Project of Application and Development of Chongqing, China (Grant No. cstc2014yykfB40001), the Natural Science Funds of Chongqing, China (Grant No. cstc2014jcyjA60003), and the Doctoral Start-up Funds of Chongqing University of Posts and Telecommunications, China (Grant No. A2012-26).

  14. Sensitivity- and effort-gain analysis: multilead ECG electrode array selection for activation time imaging.

    Hintermüller, Christoph; Seger, Michael; Pfeifer, Bernhard; Fischer, Gerald; Modre, Robert; Tilg, Bernhard

    2006-10-01

    Methods for noninvasive imaging of electric function of the heart might become clinical standard procedure the next years. Thus, the overall procedure has to meet clinical requirements as an easy and fast application. In this paper, we propose a new electrode array which improves the resolution of methods for activation time imaging considering clinical constraints such as easy to apply and compatibility with routine leads. For identifying the body-surface regions where the body surface potential (BSP) is most sensitive to changes in transmembrane potential (TMP), a virtual array method was used to compute local linear dependency (LLD) maps. The virtual array method computes a measure for the LLD in every point on the body surface. The most suitable number and position of the electrodes within the sensitive body surface regions was selected by constructing effort gain (EG) plots. Such a plot depicts the relative attainable rank of the leadfield matrix in relation to the increase in number of electrodes required to build the electrode array. The attainable rank itself was computed by a detector criterion. Such a criterion estimates the maximum number of source space eigenvectors not covered by noise when being mapped to the electrode space by the leadfield matrix and recorded by a detector. From the sensitivity maps, we found that the BSP is most sensitive to changes in TMP on the upper left frontal and dorsal body surface. These sensitive regions are covered best by an electrode array consisting of two L-shaped parts of approximately 30 cm x 30 cm and approximately 20 cm x 20 cm. The EG analysis revealed that the array meeting clinical requirements best and improving the resolution of activation time imaging consists of 125 electrodes with a regular horizontal and vertical spacing of 2-3 cm.

  15. Studies of relative gain and timing response of fine-mesh photomultiplier tubes in high magnetic fields

    Sulkosky, Vincent A. [Univ. of Virginia, Charlottesville, VA (United States); Allison-Russell, Lyndsey L. [Hampton Univ., Hampton, VA (United States); Barber, Corinne C. [Univ. of South Carolina, Columbia, SC (United States); Cao, Tongtong [Univ. of South Carolina, Columbia, SC (United States); Ilieva, Yordanka [Univ. of South Carolina, Columbia, SC (United States); Jin, Kai [Univ. of Virginia, Charlottesville, VA (United States); Kalicy, Grzegorz [Old Dominion Univ., Norfolk, VA (United States); Park, K. [Old Dominion Univ., Norfolk, VA (United States); Ton, N. [Univ. of Virginia, Charlottesville, VA (United States); Zheng, Xiaochao [Univ. of Virginia, Charlottesville, VA (United States)

    2016-05-01

    We investigated the use of Hamamatsu fine-mesh photomultiplier tube assemblies H6152-70 and H6614-70 with regards to their gain and timing resolution in magnetic fields up to 1.9 T. Our results show that the H6614-70 assembly can operate reliably in magnetic fields exceeding 1.5 T, while preserving a reasonable timing resolution even with a gain reduction of a factor of ~100. The reduction of the relative gain of the H6152-70 is similar to the H6614-70's near 1.5 T, but its timing resolution worsens considerably at this high field.

  16. High indium content graded channel GainAs/AlinAs pseudomorphic MODFETs

    Laskar, J.; Kolodzey, J.; Boor, S.; Hsieh, K. C.; Kalem, S.; Caracci, S.; Ketterson, A. A.; Brock, T.; Adesida, I.; Sivco, D.; Cho, A. Y.

    1990-03-01

    We report on the electrical and microstructural properties of InP/GaxIn 1 -xAs/Al0.48In0.52As modulation doped layers having compositionally graded active channels with different channel thicknesses. The layers were grown by solid source molecular beam epitaxy on Fe-doped InP substrates. The undoped GaInAs two dimensional electron gas channel layers were grown having indium compositions graded from x = 0.53 at the substrate buffer to x= 0.65 at the heterointerface by varying the Ga cell temperature during growth. Active channel thicknesses of 20 nm and 30 nm were compared with lattice matched layers. Transmission electron microscope image analysis indicates no misfit dislocations in these structures. Hall-effect measurements at 300 K show an increase in the mobility from 8,380 cm2/Vs for the lattice matched layer to 12,500 cm2/Vs for the 30 nm pseudomorphic layer. Small gate-length, 0.25 μn, MODFETs were fabricated to determine effective velocity values from transconductance ( g m ) and current gain ( h 21 ) measurements. The peak dc extrinsic g m increased from 367 mS/mm for the lattice matched layer to 668 mS/mm for the 30 nm pseudomorphic layer. The effective electron carrier velocity increased from 1.57 × 107 cm/s for the lattice matched layer to 1.88 × 107 cm/s for the 30 nm pseudomorphic layer. Our results show that compositional grading is a useful technique to obtain thick pseudomorphic layers with good transport properties.

  17. High-intensity resistance training amplifies muscle hypertrophy and functional gains in persons with Parkinson's disease.

    Dibble, Leland E; Hale, Tessa F; Marcus, Robin L; Droge, John; Gerber, J Parry; LaStayo, Paul C

    2006-09-01

    Strength deficits in persons with Parkinson's disease (PD) have been identified as a contributor to bradykinesia. However, there is little research that examines the effect of resistance training on muscle size, muscle force production, and mobility in persons with PD. The purpose of this exploratory study was to examine, in persons with PD, the changes in quadriceps muscle volume, muscle force production, and mobility as a result of a 12-week high-force eccentric resistance training program and to compare the effects to a standard-care control. Nineteen individuals with idiopathic PD were recruited and consented to participate. Matched assignment for age and disease severity resulted in 10 participants in the eccentric group and 9 participants in the control group. All participants were tested prior to and following a 12-week intervention period with testing and training conducted at standardized times in their medication cycle. The eccentric group performed high-force quadriceps contractions on an eccentric ergometer 3 days a week for 12 weeks. The standard-care group exercise program encompassed standard exercise management of PD. The outcome variables were quadriceps muscle volume, muscle force, and mobility measures (6-minute walk, stair ascent/descent time). Each outcome variable was tested using separate one-way analyses of covariance on the difference scores. Muscle volume, muscle force, and functional status improvements occurred in persons with PD as a result of high-force eccentric resistance training. The eccentric group demonstrated significantly greater difference scores for muscle structure, stair descent, and 6-minute walk (P eccentric group consistently exceeded those in the standard-care group for all variables. To our knowledge, this is the first clinical trial to investigate and demonstrate the effects of eccentric resistance training on muscle hypertrophy, strength, and mobility in persons with PD. Additional research is needed to determine the

  18. Electrical vagus nerve stimulation decreases food consumption and weight gain in rats fed a high-fat diet.

    Gil, Krzysztof; Bugajski, A; Thor, P

    2011-12-01

    There is growing evidence that vagus nerve stimulation (VNS) has a suppressive effect on both short- and long-term feeding in animal models. We previously showed that long-term VNS (102 days) with low-frequency electrical impulses (0.05 Hz) decreased food intake and body weight in rats. In the present study, we investigated the effect of high frequency (10 Hz) VNS on feeding behavior and appetite in rats fed a high-fat diet; peptide secretion and other parameters were assessed as well. Adult male Wistar rats were each implanted subcutaneously with a microstimulator (MS) and fed a high-fat diet throughout the entire study period (42 days). The left vagus nerve was stimulated by rectangular electrical pulses (10 ms, 200 mV, 10 Hz, 12 h a day) generated by the MS. Body weight and food intake were measured each morning. At the end of the experimental period, animals were euthanized and blood samples were taken. Serum levels of ghrelin, leptin and nesfatin-1 were assessed using radioimmunoassays. Adipose tissue content was evaluated by weighing epididymal fat pads, which were incised at the time of sacrifice. To determine whether VNS activated the food-related areas of the brain, neuronal c-Fos induction in the nuclei of the solitary tract (NTS) was assessed. Chronic vagus nerve stimulation significantly decreased food intake, body weight gain and epididymal fat pad weight in animals that received VNS compared with control animals. Significant neuronal responses in the NTS were observed following VNS. Finally, serum concentrations of ghrelin were increased, while serum levels of leptin were decreased. Although not significant, serum nesfatin-1 levels were also elevated. These results support the theory that VNS leads to reductions in food intake, body weight gain and adipose tissue by increasing brain satiety signals conducted through the vagal afferents. VNS also evoked a feed-related hormonal response, including elevated blood concentrations of nesfatin-1.

  19. High speed gain coupled DFB laser diode integrated with MQW electroabsorption modulator

    Kim, M G; Park, S S; Oh, D K; Lee, H T; Kim, H M; Pyun, K E

    1998-01-01

    We have demonstrated stable modulation characteristics of the gain coupled distributed feedback(GC-DFB) laser diode integrated with butt-coupled InGaAsP/InGaAsP strain compensated MQW(multiple-Quantum-well) modulator for high speed optical transmission. For this purpose, we have adopted the InGaAsP/InGaAsP strain compensated MQW structure for the EA modulator and n-doped InGaAs absorptive grating for DFB laser. The typical threshold current and slope efficiency were about 15 mA and 0.1 mW/mA, respectively. The extinction ratio of fabricated integrated device was about 15 dB at -2 V, and the small signal bandwidth was shown to be around 17GHz. We also found that the alpha parameter becomes negative at below a -0.6 V bias voltage. We transmitted 10 Gbps NRZ electrical signal over 90 km of standard single mode optical fiber (SMF). A clearly opened eye diagram was observed in the modulated output.

  20. Spacecraft Angular Rates Estimation with Gyrowheel Based on Extended High Gain Observer

    Xiaokun Liu

    2016-04-01

    Full Text Available A gyrowheel (GW is a kind of electronic electric-mechanical servo system, which can be applied to a spacecraft attitude control system (ACS as both an actuator and a sensor simultaneously. In order to solve the problem of two-dimensional spacecraft angular rate sensing as a GW outputting three-dimensional control torque, this paper proposed a method of an extended high gain observer (EHGO with the derived GW mathematical model to implement the spacecraft angular rate estimation when the GW rotor is working at large angles. For this purpose, the GW dynamic equation is firstly derived with the second kind Lagrange method, and the relationship between the measurable and unmeasurable variables is built. Then, the EHGO is designed to estimate and calculate spacecraft angular rates with the GW, and the stability of the designed EHGO is proven by the Lyapunov function. Moreover, considering the engineering application, the effect of measurement noise in the tilt angle sensors on the estimation accuracy of the EHGO is analyzed. Finally, the numerical simulation is performed to illustrate the validity of the method proposed in this paper.

  1. Spacecraft Angular Rates Estimation with Gyrowheel Based on Extended High Gain Observer.

    Liu, Xiaokun; Yao, Yu; Ma, Kemao; Zhao, Hui; He, Fenghua

    2016-04-14

    A gyrowheel (GW) is a kind of electronic electric-mechanical servo system, which can be applied to a spacecraft attitude control system (ACS) as both an actuator and a sensor simultaneously. In order to solve the problem of two-dimensional spacecraft angular rate sensing as a GW outputting three-dimensional control torque, this paper proposed a method of an extended high gain observer (EHGO) with the derived GW mathematical model to implement the spacecraft angular rate estimation when the GW rotor is working at large angles. For this purpose, the GW dynamic equation is firstly derived with the second kind Lagrange method, and the relationship between the measurable and unmeasurable variables is built. Then, the EHGO is designed to estimate and calculate spacecraft angular rates with the GW, and the stability of the designed EHGO is proven by the Lyapunov function. Moreover, considering the engineering application, the effect of measurement noise in the tilt angle sensors on the estimation accuracy of the EHGO is analyzed. Finally, the numerical simulation is performed to illustrate the validity of the method proposed in this paper.

  2. BiCMOS operational amplifier with precise and stable dc gain for high-frequency switched capacitor circuits

    Baschirotto, A.; Alini, R.; Castello, R.

    1991-07-01

    A novel approach in the design of high-frequency switched capacitor (SC) circuits is presented. It is based on the use of simple and fast amplifiers with low but precisely controlled gain value. The effect of the precisely known and stable opamp gain is compensated for by changing the capacitor values during the synthesis of the SC cell. An example of an opamp with these features and the synthesis of a biquadratic filter based on this approach are given.

  3. Fructans from Agave tequilana with a Lower Degree of Polymerization Prevent Weight Gain, Hyperglycemia and Liver Steatosis in High-Fat Diet-Induced Obese Mice

    Márquez-Aguirre, A. L.; Camacho-Ruíz, R. M.; Gutiérrez-Mercado, Y. K.; Padilla-Camberos, E.; González-Ávila, M.; Gálvez-Gastélum, F. J.; N.E. Díaz-Martínez; Ortuño-Sahagún, D.

    2016-01-01

    Fructans from agave have received specific attention because of their highly branched fructan content. We have previously reported that the degree of polymerization (dp) influences their biological activity. Therefore, the aim of this study was to investigate the effect of unfractionated and fractionated fructans (higher and lower dps) from Agave tequilana in high-fat diet-induced (HFD) obese mice. Fructans with a lower dp (HFD+ScF) decreased weight gain by 30 %, body fat mass by 51 %, hyperg...

  4. SOFT X-RAY FEL BY CASCADING STAGES OF HIGH GAIN HARMONIC GENERATION.

    YU,L.H.

    2003-04-17

    Short wavelength Free-Electron Lasers are perceived as the next generation of synchrotron light sources. In the past decade, significant advances have been made in the theory and technology of high brightness electron beams and single pass FELs. These developments facilitate the construction of practical VUV FELs and make x-ray FELs possible. Self-Amplified Spontaneous Emission (SASE) and High Gain Harmonic Generation (HGHG)[17-19] are the two leading candidates for x-ray FELs. The first lasing of HGHG proof-of-principle experiment succeeded in August, 1999 in Brookhaven National Laboratory. The experimental results agree with the theory prediction. Compared with SASE FEL, the following advantages of HGHG FEL were confirmed; (1) Better longitudinal coherence, and hence, much narrower bandwidth than SASE. (2) More stable central wavelength, (3) More stable output energy. In this introduction, we will first briefly describe the principle of HGHG in Section A. Then in Section B, we give a general description about how to produce soft x-ray by cascading HGHG scheme. In section 2, we give a detailed description of the system design. Then, in section 3, we give a description of an analytical estimate for the HGHG process, and the calculation of the parameters of different parts of the system. The estimate is found to agree with simulation within about a factor 2 for most cases we studied. The stability issue, the sensitivity to parameter variation, the harmonic contents of the final output, and the noise degradation issue of such HGHG scheme are discussed in Section 4. The results are presented in Section 4. Finally, in Section 5, we will give some discussion of the challenges in development of the system. The conclusion is given in Section 6.

  5. Dynamic Sliding Mode Evolution PWM Controller for a Novel High-Gain Interleaved DC-DC Converter in PV System

    Taizhou Bei

    2014-01-01

    Full Text Available Considering the disadvantages of the traditional high-gain DC-DC converter such as big size, high voltage stress of switches, and large input current ripple, a novel high-gain interleaved boost converter with coupled-inductor and switched-capacitor was proposed correspondingly and the operation principle together with the steady-state analysis of this converter was also described. Besides, a new control approach-dynamic sliding mode evolution PWM controller (DSME PWM for the novel topological converter based on both dynamic evolution and sliding mode control was also presented. From the simulation results and experimental validation the proposed converter can fulfill high-gain boost, low ripple of both the input current and the output voltage. Furthermore, MPPT technique can be also achieved in a short time by simulation. The efficiency and stability of the converter proposed in this paper can be improved.

  6. Design and performance of an Automatic Gain Control system for the High Energy X-Ray Timing Experiment

    Pelling, Michael R.; Rothschild, Richard E.; Macdonald, Daniel R.; Hertel, Robert; Nishiie, Edward

    1991-01-01

    The High Energy X-Ray Timing Experiment (HEXTE), currently under development for the X-Ray Timing Explorer (XTE) mission, employs a closed loop gain control system to attain 0.5 percent stabilization of each of eight-phoswich detector gains. This Automatic Gain Control (AGC) system utilizes a split window discriminator scheme to control the response of each detector pulse height analyzer to gated Am-241 X-ray events at 60 keV. A prototype AGC system has been implemented and tested within the gain perturbation environment expected to be experienced by the HEXTE instrument in flight. The AGC system and test configuration are described. Response, stability and noise characteristics are measured and compared with theoretical predictions. The system is found to be generally suitable for the HEXTE application.

  7. Effects of Dietary Carbohydrate Sources on Daily Weight Gain and Digestive Enzyme Activities of Juvenile Peanut Worm(Sipunculus nudus)

    Zhang Qin; Xu Mingzhu; Tong Tong; Dong Lanfang

    2015-01-01

    In the study,glucose,sucrose,dextrin,tapioca starch,potato starch,corn starch and gelatinized corn starch were selected to make the diets with same nitrogen and lipid,and Juvenile peanut worms( Sipunculus nudus) were fed with the diets came from different carbohydrate sources,effects of diets with different carbohydrate sources on daily weight gain and digestive enzyme activities of S. nudus were studied. Results showed that diets with different carbohydrate sources had significant influences on daily weight gain and digestive enzyme activities of S. nudus( P < 0. 05). Daily weight gain in gelatinized corn starch group was significantly higher than that in other groups( P < 0. 05); daily weight gain in glucose group was significantly lower than that in other groups( P < 0. 05); daily weight gain in the three ungelatinized starch groups was significantly higher than that in glucose,sucrose and dextrin groups( P < 0. 05). Analysis of digestive enzyme activities showed that dietary carbohydrate sources had significant influences on digestive enzyme activities of S. nudus( P < 0. 05). Protease activities and amylase activities of S. nudus in sucrose group were the highest,which were significantly higher than that in the other groups( P < 0. 05); lipase activities of S. nudus in glucose group were the lowest,which were significantly lower than that in other groups( P < 0. 05). In conclusion,growth-promoting effects of macromolecules carbohydrates( starch) were better than that of disaccharide( sucrose) and monosaccharide( glucose),which of gelatinized starch were better than that of ungelatinized starch.

  8. A high conversion-gain Q-band InP DHBT subharmonic mixer using LO frequency doubler

    Johansen, Tom Keinicke; Vidkjær, Jens; Krozer, Viktor;

    2008-01-01

    The paper presents analysis and design of a Q-band subharmonic mixer (SHM) with high conversion gain. The SHM consists of a local oscillator (LO) frequency doubler, RF pre-amplifier, and single-ended mixer. The SHM has been fabricated in a high-speed InP double heterojunction bipolar transistor...

  9. Gaining A Geological Perspective Through Active Learning in the Large Lecture Classroom

    Kapp, J. L.; Richardson, R. M.; Slater, S. J.

    2008-12-01

    NATS 101 A Geological Perspective is a general education course taken by non science majors. We offer 600 seats per semester, with four large lecture sections taught by different faculty members. In the past we have offered optional once a week study groups taught by graduate teaching assistants. Students often feel overwhelmed by the science and associated jargon, and many are prone to skipping lectures altogether. Optional study groups are only attended by ~50% of the students. Faculty members find the class to be a lot of work, mainly due to the grading it generates. Activities given in lecture are often short multiple choice or true false assignments, limiting the depth of understanding we can evaluate. Our students often lack math and critical thinking skills, and we spend a lot of time in lecture reintroducing ideas students should have already gotten from the text. In summer 2007 we were funded to redesign the course. Our goals were to 1) cut the cost of running the course, and 2) improve student learning. Under our redesign optional study groups were replaced by once a week mandatory break out sessions where students complete activities that have been introduced in lecture. Break out sessions substitute for one hour of lecture, and are run by undergraduate preceptors and graduate teaching assistants (GTAs). During the lecture period, lectures themselves are brief with a large portion of the class devoted to active learning in small groups. Weekly reading quizzes are submitted via the online course management system. Break out sessions allow students to spend more time interacting with their fellow students, undergraduate preceptors, and GTAs. They get one on one help in break out sessions on assignments designed to enhance the lecture material. The active lecture format means less of their time is devoted to listening passively to a lecture, and more time is spent peer learning an interacting with the instructor. Completing quizzes online allows students

  10. A PMT-like high gain avalanche photodiode based on GaN/AlN periodical stacked structure

    Zheng, Ji-yuan; Yang, Di; Yu, Jia-dong; Meng, Xiao; E, Yan-xiong; Wu, Chao; Hao, Zhi-biao; Sun, Chang-zheng; Xiong, Bing; Luo, Yi; Han, Yan-jian; Wang, Jian; Li, Hong-tao; Brault, Julien; Matta, Samuel; Khalfioui, Mohamed Al; Yan, Jian-chang; Wei, Tong-bo; Zhang, Yun; Wang, Jun-xi

    2016-01-01

    Avalanche photodiode (APD) has been intensively investigated as a promising candidate to replace photomultiplier tubes (PMT) for weak light detection. However, in conventional APDs, a large portion of carrier energy drawn from the electric field is thermalized, and the multiplication efficiencies of electron and hole are low and close. In order to achieve high gain, the device should work under breakdown bias, where carrier multiplication proceeds bi-directionally to form a positive feedback multiplication circle. However, breakdown is hard to control, in practice, APDs should work under Geiger mode as a compromise between sustainable detection and high gain. The complexity of system seriously restricts the application. Here, we demonstrate an avalanche photodiode holding high gain without breakdown, which means no quenching circuit is needed for sustainable detection. The device is based on a GaN/AlN periodically-stacked-structure (PSS), wherein electron holds much higher efficiency than hole to draw energy ...

  11. Double-pass ytterbium-doped fiber amplifier with high gain coefficient and low noise figure

    Anting Wang(王安廷); Meishu Xing(邢美术); Guanghui Chen(陈光辉); Wenkui Yang(杨文奎); Hai Ming(明海); Jianping Xie(谢建平); Yunxia Wu(吴云霞)

    2003-01-01

    We have proposed and demonstrated a double-pass ytterbium-doped fiber amplifier using an optical circulator and a fiber Bragg grating as reflector. When the signal has passed through the ytterbium-doped fiber once, it reflects off a 0.2-nm passive fiber Bragg grating filter. This reduces amplified spontaneous emission (ASE) noise from the first pass. The input signal light is amplified both forward and backward through ytterbium-doped fiber. With this double-pass configuration, 1053.15-nm unsaturated signal gain of 28 dB, gain coefficient of 1.1 dB/mW, and noise figure of less than 4 dB are achieved at 977-nm pump power of 68 mW. It is also found that this double-pass configure provides enhancing gain coefficient and improving noise figure by comparison with single-pass configuration.

  12. The Effects of Activity and Gain Based Virtual Material on Student's Success, Permanency and Attitudes towards Science Lesson

    Tas, Erol

    2015-01-01

    The main objective of this study is to research the effects of a student gains and activity based virtual material on students' success, permanence and attitudes towards science lesson, developed for science and technology lesson 6th grade "Systems in our body" unit. The study, which had a quasi-experimental design, was conducted with…

  13. Steps Ahead: Adaptation of physical activity and dietary guidelines for reducing unhealthy weight gain in the Lower Misissippi Delta

    The purpose of our study was to test the effectiveness of adapting the Dietary Guidelines for Americans (2010) (DG), with and without a physical activity (PA) component, in reducing weight gain in the Lower Mississippi Delta region (LMD) of the United States. A sample of 121 White and African-Americ...

  14. High energy gain in three-dimensional simulations of light sail acceleration

    Sgattoni, A., E-mail: andrea.sgattoni@polimi.it [Dipartimento di Energia, Politecnico di Milano, Milano (Italy); CNR, Istituto Nazionale di Ottica, u.o.s. “Adriano Gozzini,” Pisa (Italy); Sinigardi, S. [CNR, Istituto Nazionale di Ottica, u.o.s. “Adriano Gozzini,” Pisa (Italy); Dipartimento di Fisica e Astronomia, Università di Bologna, Bologna (Italy); INFN sezione di Bologna, Bologna (Italy); Macchi, A. [CNR, Istituto Nazionale di Ottica, u.o.s. “Adriano Gozzini,” Pisa (Italy); Dipartimento di Fisica “Enrico Fermi,” Università di Pisa, Pisa (Italy)

    2014-08-25

    The dynamics of radiation pressure acceleration in the relativistic light sail regime are analysed by means of large scale, three-dimensional (3D) particle-in-cell simulations. Differently to other mechanisms, the 3D dynamics leads to faster and higher energy gain than in 1D or 2D geometry. This effect is caused by the local decrease of the target density due to transverse expansion leading to a “lighter sail.” However, the rarefaction of the target leads to an earlier transition to transparency limiting the energy gain. A transverse instability leads to a structured and inhomogeneous ion distribution.

  15. The role of diet and physical activity in post-transplant weight gain after renal transplantation

    Zelle, Dorien M.; Kok, Trijntje; Dontje, Manon L.; Danchell, Eva I.; Navis, Gerjan; van Son, Willem J.; Bakker, Stephan J. L.; Corpeleijn, Eva

    2013-01-01

    Background Long-term survival of renal transplant recipients (RTR) has not improved over the past 20yr. The question rises to what extent lifestyle factors play a role in post-transplant weight gain and its associated risks after transplantation. Methods Twenty-six RTR were measured for body weight,

  16. Modelling Plant and Soil Nitrogen Feedbacks Affecting Forest Carbon Gain at High CO2

    McMurtrie, R. E.; Norby, R. J.; Franklin, O.; Pepper, D. A.

    2007-12-01

    Short-term, direct effects of elevated atmospheric CO2 concentrations on plant carbon gain are relatively well understood. There is considerable uncertainty, however, about longer-term effects, which are influenced by various plant and ecosystem feedbacks. A key feedback in terrestrial ecosystems occurs through changes in plant carbon (C) allocation patterns. For instance, if high CO2 were to increase C allocation to roots, then plants may experience positive feedback through improved plant nutrition. A second type of feedback, associated with decomposition of soil-organic matter, may reduce soil-nutrient availability at high CO2. This paper will consider mechanistic models of both feedbacks. Effects of high CO2 on plant C allocation will be investigated using a simple model of forest net primary production (NPP) that incorporates the primary mechanisms of plant carbon and nitrogen (N) balance. The model called MATE (Model Any Terrestrial Ecosystem) includes an equation for annual C balance that depends on light- saturated photosynthetic rate and therefore on [CO2], and an equation for N balance incorporating an expression for N uptake as a function of root mass. The C-N model is applied to a Free Air CO2 Exchange (FACE) experiment at Oak Ridge National Laboratory (ORNL) in Tennessee, USA, where closed-canopy, monoculture stands of the deciduous hardwood sweetgum ( Liquidambar styraciflua) have been growing at [CO2] of 375 and 550 ppm for ten years. Features of this experiment are that the annual NPP response to elevated CO2 has averaged approximately 25% over seven years, but that annual fine-root production has almost doubled on average, with especially large increases in later years of the experiment (Norby et al. 2006). The model provides a simple graphical approach for analysing effects of elevated CO2 and N supply on leaf/root/wood C allocation and productivity. It simulates increases in NPP and fine-root production at the ORNL FACE site that are consistent

  17. Noticeable positive Doppler effect on optical bistability in an N-type active Raman gain atomic system

    Chang Zeng-Guang; Niu Yue-Ping; Zhang Jing-Tao; Gong Shang-Qing

    2012-01-01

    We theoretically investigate the Doppler effect on optical bistability in an N type active Raman gain atomic system inside an optical ring cavity.It is shown that the Doppler effect can greatly enhance the dispersion and thus create the bistable behaviour or greatly increase the bistable region,which has been known as the positive Doppler effect on optical bistability.In addition,we find that a positive Doppler effect can change optical bistability from the hybrid dispersion-gain type to a dispersive type.

  18. Designing Gain- and Loss-Framed Messages to Increase Physical Activity among University Students Living in two Different Cultures

    Pelin Ozgur Polat

    2015-01-01

    BACKGROUND Widespread evidence indicates that physical activity has positive effects on physical health in long-run. Therefore, adopting exercising habits at early ages is essential for reducing risk of developing chronic diseases. As a result, prevention studies frequently focus on informing young people about possible consequences of engaging or not engaging in physical activity to encourage them to develop a healthy lifestyle. Gain- and loss-framed health messages (Rothman & Salove...

  19. Modified unscented Kalman filter using modified filter gain and variance scale factor for highly maneuvering target tracking

    Changyun Liu; Penglang Shui; Gang Wei; Song Li

    2014-01-01

    To improve the low tracking precision caused by lagged filter gain or imprecise state noise when the target highly maneu-vers, a modified unscented Kalman filter algorithm based on the improved filter gain and adaptive scale factor of state noise is pre-sented. In every filter process, the estimated scale factor is used to update the state noise covariance Qk, and the improved filter gain is obtained in the filter process of unscented Kalman filter (UKF) via predicted variance Pk|k-1, which is similar to the standard Kalman filter. Simulation results show that the proposed algorithm provides better accuracy and ability to adapt to the highly maneu-vering target compared with the standard UKF.

  20. Large delay tunable slow-light based on high-gain stimulated-Brillouin-scattering amplification in optical fibers

    XING Liang; ZHAN Li; XIA YuXing

    2009-01-01

    Tunable stimulated-Brillouin-scattering (SBS)-based slow-light in optical fibers has potential applications in optical buffering in the future all-optical router commutation systems.However,due to the low SBS threshold and relatively high realistic signal power,the gain in the usual SBS systems is limited at~30 dB.This paper presents a high-gain SBS scheme to realize large delay slow-light,which benefits from avoiding the depletion of the pump power in a short fiber as SBS media.The experiment demon strates that,up to 50 dB non-saturated gain has been observed in the single-stage 591.8 m fiber SBS amplification.The slow-light delay can be obtained 52 ns,and the fractional delay can exceed 1.

  1. No further gain can be achieved by calculating Disease Activity Score in 28 joints with high-sensitivity assay of C-reactive protein because of high intraindividual variability of C-reactive protein: A cross-sectional study and theoretical consideration.

    Hansen, Inger M J; Emamifar, Amir; Andreasen, Rikke A; Antonsen, Steen

    2017-01-01

    Disease Activity Score in 28 joints (DAS28) is commonly used to evaluate disease activity of rheumatoid arthritis (RA) and is a guide to treatment decision.The aim of this study was to evaluate the impact of lower reporting limit for C-reactive protein (CRP), with respect to intraindividual biological variability, on the calculation of DAS28 and subsequent patient classification.This study consists of 2 sections: a theoretical consideration discussing the performance of CRP in calculating DAS28 taking intraindividual biological variation and lower reporting limit for CRP into account and a cross-sectional study of RA patients applying our theoretical results. Therefore, we calculated DAS28 twice, with the actual CRP values and CRP = 9 mg/L, the latter to elucidate the positive effects of reducing the lower reporting limit of CRP from <10 to <3 mg/L.Lower-reporting limit of <10 mg/L leads to overestimate DAS28. However, reducing lower reporting limit for CRP to <3 mg/L results in optimizing DAS28 calculation. Further lowering of reporting limit for CRP to <3 mg/L does not increase the precision of DAS28 owing to the relatively large intraindividual biological variation.Five hundred twelve patients were included. There was a significant difference between recalculated and patients DAS28 (P < 0.001). One hundred nine patients had DAS28 deviation (compatible to remission to low: 66, low to moderate: 39. and moderate to high: 4).Owing to significant impact of intraindividual biologic variation on DAS28 and patient classification, special attention should be paid to calculate DAS28 when CRP values are within normal range. Furthermore, we conclude that results of different studies evaluating DAS28 and treatment response are not comparable if the reporting limits of CRP are unknown.

  2. High-power gain-switched Tm(3+)-doped fiber laser.

    Tang, Yulong; Xu, Lin; Yang, Yi; Xu, Jianqiu

    2010-10-25

    Gain-switched by a 1.914-µm Tm:YLF crystal laser, a two-stage Tm(3+) fiber laser has been achieved 100-W level ~2-µm pulsed laser output with a slope efficiency of ~52%. With the 6-m length of Tm fiber, the laser wavelength was centered at 2020 nm with a bandwidth of ~25 nm. Based on an acousto-optic switch, the pulse repetition rate can be modulated from 500 Hz to 50 kHz, and the laser pulse width can be tuned between 75 ns and ~1 µs. The maximum pulse energy was over 10 mJ, and the maximum pulse peak power was 138 kW. By using the fiber-coiling-induced mode-filtering effect, laser beam quality of M2 = 1.01 was obtained. Further scaling the pulse energy and average power from such kind of gain-switched fiber lasers was also discussed.

  3. High gain micro-channel plate multipliers for particle tracking or single photo-electron counting

    Oba, K.; Rehak, P.; Smith, S.D.

    1980-01-01

    Micro-channel plate multipliers have been used to detect the passage of relativistic charged particles. Measurements of the detection efficiency and pulse height response versus micro-channel plate gain are presented for one, two and three micro-channel plate arrays. Values describing temporal response and transit time jitter are also given. In a separate measurement, the response of a single micro-channel plate to individual slow electrons (less than or equal to 1 keV) was studied. By using a special technique output bunches as small as three electrons may be seen for low average micro-channel plate gain. The results of attempts to improve the micro-channel plate response are also presented.

  4. Investigation of hole-blocking contacts for high-conversion-gain amorphous selenium detectors for X-ray imaging

    Abbaszadeh, S.; Allec, N.; Ghanbarzadeh, S.; Shafique, U.; Karim, K.S.

    2012-01-01

    In this paper, we investigated different organic and inorganic hole-blocking contacts for amorphous selenium (a-Se)-based photodetectors: CeO2, TiO2, perylene tetracarboxylic bisbenzimidazole (PTCBI), and polyimide (PI). CeO2 has previously been used as a blocking layer for high-gain a-Se devices. T

  5. Eigenmodes and mode competition in a high-gain free-electron laser including alternating-gradient focusing

    Wu Ju Ha

    2001-01-01

    We solve the eigenvalue problem for a high gain free-electron laser in the 'water-bag' model including alternating-gradient focusing by a variational-solution-based (VSB) expansion method. Such VSB expansion method is very efficient for finding the eigenvalue. The results agree with those obtained by numerical simulation quite well. We further discuss the mode degeneracy and mode competition.

  6. Quantum spatial correlations in high-gain parametric down-conversion measured by means of a CCD camera

    Jedrkiewicz, O.; Brambilla, E.; Bache, Morten

    2006-01-01

    We consider travelling-wave parametric down-conversion in the high-gain regime and present the experimental demonstration of the quantum character of the spatial fluctuations in the system. In addition to showing the presence of sub-shot noise fluctuations in the intensity difference, we demonstr...

  7. High gain semiconductor optical amplifier — Laser diode at visible wavelength

    Shen, Chao

    2017-02-07

    We reported on the first experimental demonstration of a two-section semipolar InGaN-based laser diode with monolithically integrated semiconductor optical amplifier (SOA-LD). The onset of amplification effect was measured at 4V SOA bias (VSOA). The SOA-LD shows a large gain of 5.32 dB at Vsoa = 6 V.

  8. Novel T-Z source inverter with high voltage gain and reduced transformer turn ratio

    Mostaan, Ali; Sharifi Malfejani, Saeed; Soltani, Mohsen

    2015-01-01

    Novel voltage source inverter based on the Z source inverter structure is introduced in this paper. In this new inverter, two inductors of the impedance network in conventional Z source inverter are replaced with two transformers or coupled inductors, but unlike the T-Z source inverter that it's ...... cost. The proposed inverter is analyzed in steady state and its voltage gain is obtained. The performance of the proposed inverter is verified with simulation results using the MATLAB/SIMULINK software....

  9. Recent Advances on the Design of High-Gain Wideband Operational Transconductance Amplifiers

    Rida Assaad

    2009-01-01

    greater than 90 dB DC gain, GBW of 325 MHz and better than 70∘ phase margin is discussed. The settling-time- of the NCFF topology can be faster than that of OTAs with Miller compensation. Experimental results for the recycling folded-cascode OTA fabricated in TSMC 0.18 m CMOS, and results of the NCFF demonstrate the efficiency and feasibility of the feed-forward schemes.

  10. Pulse Combustor Driven Pressure Gain Combustion for High Efficiency Gas Turbine Engines

    Lisanti, Joel

    2017-02-01

    The gas turbine engine is an essential component of the global energy infrastructure which accounts for a significant portion of the total fossil fuel consumption in transportation and electric power generation sectors. For this reason there is significant interest in further increasing the efficiency and reducing the pollutant emissions of these devices. Conventional approaches to this goal, which include increasing the compression ratio, turbine inlet temperature, and turbine/compressor efficiency, have brought modern gas turbine engines near the limits of what may be achieved with the conventionally applied Brayton cycle. If a significant future step increase in gas turbine efficiency is to be realized some deviation from this convention is necessary. The pressure gain gas turbine concept is a well established new combustion technology that promises to provide a dramatic increase in gas turbine efficiency by replacing the isobaric heat addition process found in conventional technology with an isochoric process. The thermodynamic benefit of even a small increase in stagnation pressure across a gas turbine combustor translates to a significant increase in cycle efficiency. To date there have been a variety of methods proposed for achieving stagnation pressure gains across a gas turbine combustor and these concepts have seen a broad spectrum of levels of success. The following chapter provides an introduction to one of the proposed pressure gain methods that may be most easily realized in a practical application. This approach, known as pulse combustor driven pressure gain combustion, utilizes an acoustically resonant pulse combustor to approximate isochoric heat release and thus produce a rise in stagnation pressure.

  11. Gain-scheduled Linear Quadratic Control of Wind Turbines Operating at High Wind Speed

    Østergaard, Kasper Zinck; Stoustrup, Jakob; Brath, Per

    2007-01-01

    This paper addresses state estimation and linear quadratic (LQ) control of variable speed variable pitch wind turbines. On the basis of a nonlinear model of a wind turbine, a set of operating conditions is identified and a LQ controller is designed for each operating point. The controller gains....... Simulation results are given that display good performance of the observers and comparisons with a controller designed by classical methods displays the potential of the method.  ...

  12. Optimization of Drive Pulse Configuration for a High-Gain Transient X-Ray Laser at 19.6 nm

    LU Xin; LI Ying-Jun; ZHANG Jie

    2001-01-01

    An Ne-like transient collisional excitation x-ray laser at 19.6nm (J = 0 → 1, 3p - 3s) was investigated numerically using a sophisticated hydrodynamic code for a l00μm thick Ge planar target irradiated by a nanosecond pre pulse followed by a picosecond main optical laser pulse. The simulations indicate that for a given peak intensity, the main pulse has an optimal duration to generate the maximum effective gain. An effective gain as high as 200 cma-1 was obtained for the optimized drive pulse configuration.

  13. Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC).

    Zheng, Jie; van de Veerdonk, Frank L; Crossland, Katherine L; Smeekens, Sanne P; Chan, Chun M; Al Shehri, Tariq; Abinun, Mario; Gennery, Andrew R; Mann, Jelena; Lendrem, Dennis W; Netea, Mihai G; Rowan, Andrew D; Lilic, Desa

    2015-10-01

    Signal transducer and activator of transcription 3 (STAT3) triggered production of Th-17 cytokines mediates protective immunity against fungi. Mutations affecting the STAT3/interleukin 17 (IL-17) pathway cause selective susceptibility to fungal (Candida) infections, a hallmark of chronic mucocutaneous candidiasis (CMC). In patients with autosomal dominant CMC, we and others previously reported defective Th17 responses and underlying gain-of-function (GOF) STAT1 mutations, but how this affects STAT3 function leading to decreased IL-17 is unclear. We also assessed how GOF-STAT1 mutations affect STAT3 activation, DNA binding, gene expression, cytokine production, and epigenetic modifications. We excluded impaired STAT3 phosphorylation, nuclear translocation, and sequestration of STAT3 into STAT1/STAT3 heterodimers and confirm significantly reduced transcription of STAT3-inducible genes (RORC/IL-17/IL-22/IL-10/c-Fos/SOCS3/c-Myc) as likely underlying mechanism. STAT binding to the high affinity sis-inducible element was intact but binding to an endogenous STAT3 DNA target was impaired. Reduced STAT3-dependent gene transcription was reversed by inhibiting STAT1 activation with fludarabine or enhancing histone, but not STAT1 or STAT3 acetylation with histone deacetylase (HDAC) inhibitors trichostatin A or ITF2357. Silencing HDAC1, HDAC2, and HDAC3 indicated a role for HDAC1 and 2. Reduced STAT3-dependent gene transcription underlies low Th-17 responses in GOF-STAT1 CMC, which can be reversed by inhibiting acetylation, offering novel targets for future therapies.

  14. Study on optical gain of one-dimensional photonic crystals with active impurity

    Zhenghua Li; Tinggen Shen; Xuehua Song; Junfeng Ma; Yong Sheng; Gang Wang

    2007-01-01

    Localized fields in the defect mode of one-dimensional photonic crystals with active impurity are studied with the help of the theory of spontaneous emission from two-level atoms embedded in photonic crystals.Numerical simulations demonstrate that the enhancement of stimulated radiation, as well as the phenomena of transmissivity larger than unity and the abnormality of group velocity close to the edges of photonic band gap, are related to the negative imaginary part of the complex effective refractive index of doped layers. This means that the complex effective refractive index has a negative imaginary part, and that the impurity state with very high quality factor and great state density will occur in the photonic forbidden band if active impurity is introduced into the defect layer properly. Therefore, the spontaneous emission can be enhanced, the amplitude of stimulated emission will be very large and it occurs most probably close to the edges of photonic band gap with the fundamental reason, the group velocity close to the edges of band gap is very small or abnormal.

  15. Compact tunable high power picosecond source based on Yb-doped fiber amplification of gain switch laser diode.

    Liu, Hongjun; Gao, Cunxiao; Tao, Jintao; Zhao, Wei; Wang, Yishan

    2008-05-26

    A compact tunable high power picosecond source based on Yb-doped fiber amplification of gain switch laser diode is demonstrated. A multi-stage single mode Yb-doped fiber preamplifier was combined with a single mode double-clad Yb-doped fiber main amplifier to construct the amplification system, which is seeded by a gain switch laser diode. By optimizing preamplifier???s parameters to compensate the seed spectrum gain, a "flat top" broadband spectrum is obtained to realize wavelength tunable output with a self-made tunable filter. The tunable pulses were further amplified to 3.5 W average power 90 ps pulses at 1 MHz repetition rate, and the center wavelength was tunable in the ranges from 1053 nm to 1073 nm with excellent beam quality.

  16. High-gain dipole antenna using polydimethylsiloxane-glass microsphere (PDMS-GM) substrate for 5G applications

    Muhamad, Wan Asilah Wan; Ngah, Razali; Jamlos, Mohd Faizal; Soh, Ping Jack; Ali, Mohd Tarmizi

    2017-01-01

    A new dipole antenna designed using polydimethylsiloxane-glass microsphere (PDMS-GM) substrate is presented. The PDMS-GM substrate offered a lower permittivity of 1.85 compared to pure PDMS of 2.7. This resulted in a wide operating frequency range from 19 GHz up to more than 45 GHz, indicating a bandwidth of more than 28 GHz. The proposed PDMS-GM antenna featured a gain of up to 13.3 dB compared to pure PDMS which only produced 13 GHz of bandwidth and 5.5 dB gain. Instead of wide bandwidth and high gain, the proposed antenna is capable of becoming water resistant by covering its radiator and SMA connector. Such capabilities of the new PDMS-GM antenna indicated suitability for the fifth-generation (5G) wireless communication systems.

  17. Seasonal Variations of Polarization Diversity Gain in a Vegetated Area considering High Elevation Angles and a Nomadic User

    Milan Kvicera

    2015-01-01

    Full Text Available Seasonal variations of the polarization diversity gain are addressed for a nomadic user in a vegetated area taking high elevation angles and nongeostationary satellites into consideration. Corresponding experimental data were obtained at a frequency of 2.0 GHz at Stromovka Park in Prague, the Czech Republic, within the full in-leaf and out-of-leaf periods of 2013 and 2014, respectively. By detecting copolarized and cross-polarized components of the transmitted left- and right-handed circularly polarized signals, the corresponding diversity gain was obtained for multiple-input single-output (MISO, single-input multiple-output (SIMO, and combined MISO/SIMO cases. It was found that tree defoliation results in a significant decrease of the polarization diversity gain achieved for low time percentages in particular scenarios.

  18. Wideband and flat-gain amplifier based on high concentration erbium-doped fibres in parallel double-pass configuration

    Hamida, B A; Cheng, X S; Harun, S W; Naji, A W; Arof, H; Al-Khateeb, W; Khan, S; Ahmad, H

    2012-03-31

    A wideband and flat gain erbium-doped fibre amplifier (EDFA) is demonstrated using a hybrid gain medium of a zirconiabased erbium-doped fibre (Zr-EDF) and a high concentration erbium-doped fibre (EDF). The amplifier has two stages comprising a 2-m-long ZEDF and 9-m-long EDF optimised for C- and L-band operations, respectively, in a double-pass parallel configuration. A chirp fibre Bragg grating (CFBG) is used in both stages to ensure double propagation of the signal and thus to increase the attainable gain in both C- and L-band regions. At an input signal power of 0 dBm, a flat gain of 15 dB is achieved with a gain variation of less than 0.5 dB within a wide wavelength range from 1530 to 1605 nm. The corresponding noise figure varies from 6.2 to 10.8 dB within this wavelength region.

  19. Stability of Gain Scheduling Control for Aircraft with Highly Nonlinear Behavior

    Fany Mendez-Vergara

    2014-01-01

    Full Text Available The main goal of this work is to study the stability properties of an aircraft with nonlinear behavior, controlled using a gain scheduled approach. An output feedback is proposed which is able to guarantee asymptotical stability of the task-coordinates origin and safety of the operation in the entire flight envelope. The results are derived using theory of hybrid and singular perturbed systems. It is demonstrated that both body velocity and orientation asymptotic tracking can be obtained in spite of nonlinearities and uncertainty. The results are illustrated using numerical simulations in F16 jet.

  20. 93-133 GHz Band InP High-Electron-Mobility Transistor Amplifier with Gain-Enhanced Topology

    Sato, Masaru; Shiba, Shoichi; Matsumura, Hiroshi; Takahashi, Tsuyoshi; Nakasha, Yasuhiro; Suzuki, Toshihide; Hara, Naoki

    2013-04-01

    In this study, we developed a new type of high-frequency amplifier topology using 75-nm-gate-length InP-based high-electron-mobility transistors (InP HEMTs). To enhance the gain for a wide frequency range, a common-source common-gate hybrid amplifier topology was proposed. A transformer-based balun placed at the input of the amplifier generates differential signals, which are fed to the gate and source terminals of the transistor. The amplified signal is outputted at the drain node. The simulation results show that the hybrid topology exhibits a higher gain from 90 to 140 GHz than that of the conventional common-source or common-gate amplifier. The two-stage amplifier fabricated using the topology exhibits a small signal gain of 12 dB and a 3-dB bandwidth of 40 GHz (93-133 GHz), which is the largest bandwidth and the second highest gain reported among those of published 120-GHz-band amplifiers. In addition, the measured noise figure was 5 dB from 90 to 100 GHz.

  1. Normal hematopoiesis and lack of β-catenin activation in osteoblasts of patients and mice harboring Lrp5 gain-of-function mutations

    Galán-Díez, Marta; Isa, Adiba; Ponzetti, Marco;

    2016-01-01

    of hematopoiesis and leukemogenic properties of β-catenin activation in osteoblasts, that lead to development of acute myeloid leukemia (AML). Using mice with gain-of-function (GOF) Lrp5 alleles (Lrp5(A214V)) that recapitulate the human high bone mass (HBM) phenotype, as well as patients with the T253I HBM Lrp5...... patients showed normal hematopoiesis, normal percentage of myeloid cells, and lack of anemia. We conclude that Lrp5 GOF mutations do not activate β-catenin signaling in osteoblasts. As a result, myeloid lineage differentiation is normal in HBM patients and mice. This article is part of a Special Issue...

  2. Does Structured Quizzing with Process Specific Feedback Lead to Learning Gains in an Active Learning Geoscience Classroom?

    Palsole, S.; Serpa, L. F.

    2013-12-01

    There is a great realization that efficient teaching in the geosciences has the potential to have far reaching effects in outreach to decision and policy makers (Herbert, 2006; Manduca & Mogk, 2006). This research in turn informs educators that the geosciences by the virtue of their highly integrative nature play an important role in serving as an entry point into STEM disciplines and helping developing a new cadre of geoscientists, scientists and a general population with an understanding of science. Keeping these goals in mind we set to design introductory geoscience courses for non-majors and majors that move away from the traditional lecture models which don't necessarily contribute well to knowledge building and retention ((Handelsman et al., 2007; Hake, 1997) to a blended active learning classroom where basic concepts and didactic information is acquired online via webquests, lecturettes and virtual field trips and the face to face portions of the class are focused on problem solving exercises. The traditional way to ensure that students are prepared for the in-class activity is to have the students take a quiz online to demonstrate basic competency. In the process of redesign, we decided to leverage the technology to build quizzes that are highly structured and map to a process (formation of divergent boundaries for example) or sets of earth processes that we needed the students to know before in-class activities. The quizzes can be taken multiple times and provide process specific feedback, thus serving as a heuristic to the students to ensure they have acquired the necessary competency. The heuristic quizzes were developed and deployed over a year with the student data driving the redesign process to ensure synchronicity. Preliminary data analysis indicates a positive correlation between higher student scores on in-class application exercises and time spent on the process quizzes. An assessment of learning gains also indicate a higher degree of self

  3. High-gain step-profiled integrated diagonal horn-antennas

    Eleftheriades, George V.; Rebeiz, Gabriel M.

    1992-05-01

    A new step-profiled integrated-horn antenna is proposed. The antenna allows gains in the range of 17-20 dB to be achieved using standard (100) silicon wafers. The antenna is diagonally fed and exhibits very good circular symmetry within the 10-dB beamwidth. It has a fundamental Gaussian coupling efficiency of 83 percent. It is demonstrated that the profiled antenna has a radiation pattern similar to that of its smooth envelope horn, provided that the discontinuity between successive wafers does not exceed 0.15 lambda. The integrated stepped-profile horn performs much better than a corresponding smooth 70 deg flare-angle integrated horn of the same aperture size. The integrated step-profile horn is very well-suited for radio-astonomical and remote-sensing millimeter-wave imaging arrays requiring a large number of focal-plane elements.

  4. A novel broadband and high-gain microstrip reflectarray antenna with variable polarization

    Zhihang WU; Wenxun ZHANG; Zhenguo LIU; Wei SHEN

    2008-01-01

    This article proposes a new kind of microstrip reflectarray antenna, of which the polarization could be reconfigured among all the polarization states instead of some fixed states in a dual- or multi-polarized antenna. The mechanism for polarized variability is so simple that only mechanical rotation is needed. Theoretical analysis shows that the refected polarization covers all states and that the dual- or multi-layered unit structure sandwiched with air-gaps can broaden the bandwidth efficiently. Moreover, it is demonstrated that adopting more elements can enhance antenna gain. With these advanta-geous features, this kind of antenna has the potential significance for engineering applications in radar, com-munication, etc. In this article, a complete theoretical analysis as well as a specific design sample is given to verify this method.

  5. Excess Folic Acid Increases Lipid Storage, Weight Gain, and Adipose Tissue Inflammation in High Fat Diet-Fed Rats

    Kelly, Karen B.; Kennelly, John P.; Ordonez, Marta; Nelson, Randal; Leonard, Kelly; Stabler, Sally; Gomez-Muñoz, Antonio; Field, Catherine J.; Jacobs, René L.

    2016-01-01

    Folic acid intake has increased to high levels in many countries, raising concerns about possible adverse effects, including disturbances to energy and lipid metabolism. Our aim was to investigate the effects of excess folic acid (EFA) intake compared to adequate folic acid (AFA) intake on metabolic health in a rodent model. We conducted these investigations in the setting of either a 15% energy low fat (LF) diet or 60% energy high fat (HF) diet. There was no difference in weight gain, fat mass, or glucose tolerance in EFA-fed rats compared to AFA-fed rats when they were fed a LF diet. However, rats fed EFA in combination with a HF diet had significantly greater weight gain and fat mass compared to rats fed AFA (p adipose tissue of high fat-excess folic acid (HF-EFA) fed rats. Inflammation was increased in HF-EFA fed rats, associated with impaired glucose tolerance compared to high fat-adequate folic acid (HF-AFA) fed rats (p < 0.05). In addition, folic acid induced PPARγ expression and triglyceride accumulation in 3T3-L1 cells. Our results suggest that excess folic acid may exacerbate weight gain, fat accumulation, and inflammation caused by consumption of a HF diet. PMID:27669293

  6. High Magnetic Shear Gain in a Liquid Sodium Stable Couette Flow Experiment; A Prelude to an alpha-Omega Dynamo

    Colgate, Stirling A; Pariev, Vladimir; Finn, John; Beckley, Howard; Si, Jiahe; Martinic, Joe; Westpfahl, David; Slutz, James; Westrom, Cebastian; Klein, Brianna; Schendel, Paul; Scharle, Cletus; McKinney, Travis; Ginanni, Rocky; Bentley, Ian; Mickey, Timothy

    2010-01-01

    The $\\Omega$-phase of the liquid sodium $\\alpha$-$\\Omega$ dynamo experiment at NMIMT in cooperation with LANL has successfully demonstrated the production of a high toroidal field, $B_{\\phi} \\simeq 8\\times B_r$ from the radial component of an applied poloidal magnetic field, $B_r$. This enhanced toroidal field is produced by rotational shear in stable Couette flow within liquid sodium at $Rm \\simeq 120$. The small turbulence in stable Taylor-Couette flow is caused by Ekman flow where $ (\\delta v/v)^2 \\sim 10^{-3} $. This high $\\Omega$-gain in low turbulence flow contrasts with a smaller $\\Omega$-gain in higher turbulence, Helmholtz-unstable shear flows. This result supports the ansatz that large scale astrophysical magnetic fields are created within semi-coherent large scale motions in which turbulence plays only a smaller diffusive role that enables magnetic flux linkage.

  7. High-gain direct-drive inertial confinement fusion for the Laser Mégajoule: recent progress

    Canaud, B.; Garaude, F.; Ballereau, P.; Bourgade, J. L.; Clique, C.; Dureau, D.; Houry, M.; Jaouen, S.; Jourdren, H.; Lecler, N.; Masse, L.; Masson, A.; Quach, R.; Piron, R.; Riz, D.; Van der Vliet, J.; Temporal, M.; Delettrez, J. A.; McKenty, P. W.

    2007-12-01

    Recent progress in high-gain direct-drive inertial confinement fusion with the laser Mégajoule is reviewed. A new baseline direct-drive target design is presented which implodes with a two-cones irradiation pattern of indirect-drive beam configuration and zooming. Perturbation amplitudes and correlated growth rates of hydrodynamic instabilities in the compressed core of a directly driven inertial confinement fusion capsule are analyzed in planar and spherical geometries, with and without heat conduction, in the unsteady state regime of the deceleration. Shock propagation in heterogeneous media is addressed in the context of first shock. The neutron and photon emissions of high-gain direct-drive target are characterized. Numerical interpretations of directly driven homothetic cryogenic D2 target implosion experiments on the Omega facility are presented.

  8. High magnetic shear gain in a liquid sodium stable couette flow experiment A prelude to an alpha - omega dynamo

    Colgate, Stirling [Los Alamos National Laboratory; Li, Jui [Los Alamos National Laboratory; Finn, John [Los Alamos National Laboratory; Pariev, Vladimir [Los Alamos National Laboratory; Beckley, Howard [NM INSTIT. OF MINING AND TECH; Si, Jiahe [NM INSTIT. OF MINING AND TECH.; Martinic, Joe [NM INSTIT. OF MINING AND TECH.; Westpfahl, David [NM INSTIT. OF TECH.; Slutz, James [NM INSTIT. OF MINING AND TECH.; Westrom, Zeb [NM INSTIT. OF TECH.; Klein, Brianna [NM INSTIT. OF MINING AND TECH.

    2010-11-08

    The {Omega}-phase of the liquid sodium {alpha}-{Omega} dynamo experiment at NMIMT in cooperation with LANL has successfully demonstrated the production of a high toroidal field, B{sub {phi}} {approx_equal} 8 x B{sub r} from the radial component of an applied poloidal magnetic field, B{sub r}. This enhanced toroidal field is produced by rotational shear in stable Couette Row within liquid sodium at Rm {approx_equal} 120. The small turbulence in stable Taylor-Couette Row is caused by Ekman Row where ({delta}v/v){sup 2} {approx} 10{sup -3}. This high {Omega}-gain in low turbulence flow contrasts with a smaller {Omega}-gain in higher turbulence, Helmholtz-unstable shear flows. This result supports the ansatz that large scale astrophysical magnetic fields are created within semi-coherent large scale motions in which turbulence plays a diffusive role that enables magnetic flux linkage.

  9. Determinants of Developmental Gain in Daily Activities in Young Children with Cerebral Palsy.

    Kruijsen-Terpstra, Anne J A; Ketelaar, Marjolijn; Verschuren, Olaf; Smits, Dirk-Wouter; Jongmans, Marian J; Gorter, Jan Willem

    2014-09-18

    ABSTRACT The aim of this study was to examine which child and family characteristics at the child's age of 2 years are determinants of development of self-care and mobility activities over a period of 2 years in young children with cerebral palsy (CP). Longitudinal data of 92 children, representing all levels of the Gross Motor Function Classification System (GMFCS), were analyzed. Children's self-care and mobility activities were assessed with the Functional Skills Scale of the Pediatric Evaluation of Disability Inventory. Development of self-care and mobility activities was related to several child determinants but no family determinants. GMFCS, type of CP, intellectual capacity, and epilepsy were related to the development of self-care and mobility activities, while manual ability and spasticity were related to development of mobility activities. Multivariate analysis indicated that GMFCS and intellectual capacity were the strongest determinants of development of self-care activities, and GMFCS was the strongest determinant of development of mobility activities. The change in self-care and mobility activities was less favorable in severely affected children with severe disability. Knowledge of GMFCS level and intellectual capacity is important in anticipating change over time and goal setting in young children with CP.

  10. Local expectation violations result in global activity gain in primary visual cortex.

    Kok, Peter; van Lieshout, Lieke L F; de Lange, Floris P

    2016-11-22

    During natural perception, we often form expectations about upcoming input. These expectations are usually multifaceted - we expect a particular object at a particular location. However, expectations about spatial location and stimulus features have mostly been studied in isolation, and it is unclear whether feature-based expectation can be spatially specific. Interestingly, feature-based attention automatically spreads to unattended locations. It is still an open question whether the neural mechanisms underlying feature-based expectation differ from those underlying feature-based attention. Therefore, establishing whether the effects of feature-based expectation are spatially specific may inform this debate. Here, we investigated this by inducing expectations of a specific stimulus feature at a specific location, and probing the effects on sensory processing across the visual field using fMRI. We found an enhanced sensory response for unexpected stimuli, which was elicited only when there was a violation of expectation at the specific location where participants formed a stimulus expectation. The neural consequences of this expectation violation, however, spread to cortical locations processing the stimulus in the opposite hemifield. This suggests that an expectation violation at one location in the visual world can lead to a spatially non-specific gain increase across the visual field.

  11. Excess Folic Acid Increases Lipid Storage, Weight Gain, and Adipose Tissue Inflammation in High Fat Diet-Fed Rats.

    Kelly, Karen B; Kennelly, John P; Ordonez, Marta; Nelson, Randal; Leonard, Kelly; Stabler, Sally; Gomez-Muñoz, Antonio; Field, Catherine J; Jacobs, René L

    2016-09-23

    Folic acid intake has increased to high levels in many countries, raising concerns about possible adverse effects, including disturbances to energy and lipid metabolism. Our aim was to investigate the effects of excess folic acid (EFA) intake compared to adequate folic acid (AFA) intake on metabolic health in a rodent model. We conducted these investigations in the setting of either a 15% energy low fat (LF) diet or 60% energy high fat (HF) diet. There was no difference in weight gain, fat mass, or glucose tolerance in EFA-fed rats compared to AFA-fed rats when they were fed a LF diet. However, rats fed EFA in combination with a HF diet had significantly greater weight gain and fat mass compared to rats fed AFA (p folic acid (HF-EFA) fed rats. Inflammation was increased in HF-EFA fed rats, associated with impaired glucose tolerance compared to high fat-adequate folic acid (HF-AFA) fed rats (p folic acid induced PPARγ expression and triglyceride accumulation in 3T3-L1 cells. Our results suggest that excess folic acid may exacerbate weight gain, fat accumulation, and inflammation caused by consumption of a HF diet.

  12. On the Fielding of a High Gain, Shock-Ignited Target on the National Ignitiion Facility in the Near Term

    Perkins, L J; Betti, R; Schurtz, G P; Craxton, R S; Dunne, A M; LaFortune, K N; Schmitt, A J; McKenty, P W; Bailey, D S; Lambert, M A; Ribeyre, X; Theobald, W R; Strozzi, D J; Harding, D R; Casner, A; Atzemi, S; Erbert, G V; Andersen, K S; Murakami, M; Comley, A J; Cook, R C; Stephens, R B

    2010-04-12

    Shock ignition, a new concept for igniting thermonuclear fuel, offers the possibility for a near-term ({approx}3-4 years) test of high gain inertial confinement fusion on the National Ignition Facility at less than 1MJ drive energy and without the need for new laser hardware. In shock ignition, compressed fusion fuel is separately ignited by a strong spherically converging shock and, because capsule implosion velocities are significantly lower than those required for conventional hotpot ignition, fusion energy gains of {approx}60 may be achievable on NIF at laser drive energies around {approx}0.5MJ. Because of the simple all-DT target design, its in-flight robustness, the potential need for only 1D SSD beam smoothing, minimal early time LPI preheat, and use of present (indirect drive) laser hardware, this target may be easier to field on NIF than a conventional (polar) direct drive hotspot ignition target. Like fast ignition, shock ignition has the potential for high fusion yields at low drive energy, but requires only a single laser with less demanding timing and spatial focusing requirements. Of course, conventional symmetry and stability constraints still apply. In this paper we present initial target performance simulations, delineate the critical issues and describe the immediate-term R&D program that must be performed in order to test the potential of a high gain shock ignition target on NIF in the near term.

  13. Quercetin decreases high-fat diet induced body weight gain and accumulation of hepatic and circulating lipids in mice.

    Hoek-van den Hil, E F; van Schothorst, E M; van der Stelt, I; Swarts, H J M; Venema, D; Sailer, M; Vervoort, J J M; Hollman, P C H; Rietjens, I M C M; Keijer, J

    2014-09-01

    Dietary flavonoids may protect against cardiovascular diseases (CVD). Increased circulating lipid levels and hepatic lipid accumulation are known risk factors for CVD. The aim of this study was to investigate the effects and underlying molecular mechanisms of the flavonoid quercetin on hepatic lipid metabolism in mice with high-fat diet induced body weight gain and hepatic lipid accumulation. Adult male mice received a 40 energy% high-fat diet without or with supplementation of 0.33 % (w/w) quercetin for 12 weeks. Body weight gain was 29 % lower in quercetin fed mice (p lipid accumulation to 29 % of the amount present in the control mice (p lipid profiling revealed that the supplementation significantly lowered serum lipid levels. Global gene expression profiling of liver showed that cytochrome P450 2b (Cyp2b) genes, key target genes of the transcription factor constitutive androstane receptor (Car; official symbol Nr1i3), were downregulated. Quercetin decreased high-fat diet induced body weight gain, hepatic lipid accumulation and serum lipid levels. This was accompanied by regulation of cytochrome P450 2b genes in liver, which are possibly under transcriptional control of CAR. The quercetin effects are likely dependent on the fat content of the diet.

  14. Alkali-activated fly ash. Relationship between mechanical strength gains and initial ash chemistry

    Palomo, A.

    2008-09-01

    Full Text Available Alkali-activated fly ash is the primary component of a new generation of high-strength, durable binders with excellent mechanical properties and durability (on occasion bettering traditional Portland cement performance. Moreover, development of these cements may contribute to mitigating CO2 emissions, since the base material is an industrial by-product. The present study was conducted to determine the effect of the composition of the initial materials (SiO2/Al2O3 and Na2O/Al2O3 ratios on the mechanical properties, nature and composition of the reaction products. The results obtained indicate that there is no linear relationship between these ratios and mechanical strength, but rather a series of optimal values above and below which strength declines. In the specific case of the ratios studied in the present paper, these values were: SiO2/Al2O3= 4.0 and Na2O/Al2O3= 1.0 (molar ratios.Las cenizas volantes activadas alcalinamente constituyen la base de una nueva generación de cementos con muy interesantes propiedades mecánicas, adherentes y durables (a veces incluso mejores que las de los cementos Portland tradicionales. Adicionalmente el desarrollo de estos cementos podría contribuir a mitigar las emisiones de CO2 a la atmósfera, ya que el material base de los mismos puede estar formado por subproductos industriales. En la presente investigación se realizó un estudio para determinar la influencia de la composición de los materiales iniciales (ratios SiO2/Al2O3 y Na2O/Al2O3 en las propiedades mecánicas y en la naturaleza y composición de los productos de reacción. Los resultados obtenidos indican que no existe una relación lineal de dichas ratios con las resistencias mecánicas, sino que existen unos valores óptimos, por encima y debajo de los cuales las resistencias mecánicas disminuyen. En el caso concreto de las ratios estudiadas en el presente trabajo estos valores serian: SiO2/Al2O3= 4,0 y Na2O/Al2O3= 1,0 (relaciones molares

  15. Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet

    Jang, Woo Young; Bae, Ki Beom; Kim, Sung Hyun; Yu, Dong Hun; Kim, Hei Jung; Ji, Young Rae; Park, Seo Jin; Park, Si Jun; Kang, Min-Cheol; Jeong, Ja In [School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701 (Korea, Republic of); Park, Sang-Joon [College of Veterinary Medicine, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701 (Korea, Republic of); Lee, Sang Gyu [School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701 (Korea, Republic of); Lee, Inkyu [School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 700-842 (Korea, Republic of); Kim, Myoung Ok [School of Animal BT Sciences, Sangju Campus, Kyungpook National University, 386 Gajang-dong, Sangju, Gyeongsangbuk-do 742-211 (Korea, Republic of); Yoon, Duhak, E-mail: dhyoon@knu.ac.kr [School of Animal BT Sciences, Sangju Campus, Kyungpook National University, 386 Gajang-dong, Sangju, Gyeongsangbuk-do 742-211 (Korea, Republic of); Ryoo, Zae Young, E-mail: jaewoong64@hanmail.net [School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701 (Korea, Republic of)

    2014-02-14

    Highlights: • The expression of Jazf1 in the liver suppressed lipid accumulation. • Jazf1 significantly increases transcription of fatty acid synthase. • Jazf1 plays a critical role in the regulation of energy and lipid homeostasis. • Jazf1 associates the development of metabolic disorder. • Jazf1 may provide a new therapeutic target in the management of metabolic disorder. - Abstract: Jazf1 is a 27 kDa nuclear protein containing three putative zinc finger motifs that is associated with diabetes mellitus and prostate cancer; however, little is known about the role that this gene plays in regulation of metabolism. Recent evidence indicates that Jazf1 transcription factors bind to the nuclear orphan receptor TR4. This receptor regulates PEPCK, the key enzyme involved in gluconeogenesis. To elucidate Jazf1’s role in metabolism, we fed a 60% fat diet for up to 15 weeks. In Jazf1 overexpression mice, weight gain was found to be significantly decreased. The expression of Jazf1 in the liver also suppressed lipid accumulation and decreased droplet size. These results suggest that Jazf1 plays a critical role in the regulation of lipid homeostasis. Finally, Jazf1 may provide a new therapeutic target in the management of obesity and diabetes.

  16. Modified High Gain APDs for Multi-beam Ladar Instrumentation Project

    National Aeronautics and Space Administration — In this effort, Radiation Monitoring Devices, Inc (RMD) addresses NASA's request for sensitive, high quantum efficiency (QE) optical detectors for space- and...

  17. Temperature dependency of the Ga/In distribution in Cu(In,Ga)Se2 absorbers in high temperature processes

    Mueller, B. J.; Demes, T.; Lill, P. C.; Haug, V.; Hergert, F.; Zweigart, S.; Herr, U.

    2016-05-01

    The current article reports about the influence of temperature and glass substrate on Ga/In interdiffusion and chalcopyrite phase formation in the stacked elemental layer process. According to the Shockley-Queisser limit the optimum for single junction devices is near 1.4 eV, which is strongly coupled on the Ga/(Ga+In) ratio of Cu(In,Ga)Se2 thin film solar cells. To increase the Ga content in the active region of the Cu(In,Ga)Se2 a 70:30 CuGa alloy target is used. An increase of the selenization temperature leads to a more homogeneous Ga/In distribution and a less pronounced Ga agglomeration at the back contact. The Ga/In interdiffusion rates for different selenization temperatures and substrates were estimated with the model of a two layer system. At the highest selenization temperature used an absorber band gap of 1.12 eV was realized, which is similar to typical values of absorbers produced during the co-evaporation process. The Na diffusion into the Cu(In,Ga)Se2 is weakly temperature dependent but strongly influenced by the choice of the glass substrate composition.

  18. Field Plate Optimization in Low-Power High-Gain Source-Gated Transistors

    Sporea,R.A.; Trainor, M.J.; Young, N.D.; Shannon, J.M.; Silva, S.R.P.

    2012-01-01

    Source-gated transistors (SGTs) have potentially very high output impedance and low saturation voltages, which make them ideal as building blocks for high performance analog circuits fabricated in thin-film technologies. The quality of the saturation is greatly influenced by the design of the field-

  19. Determinants of Developmental Gain in Daily Activities in Young Children with Cerebral Palsy

    Kruijsen-Terpstra, Anne J A; Ketelaar, Marjolijn; Verschuren, Olaf; Smits, Dirk-Wouter; Jongmans, Marian J; Gorter, Jan Willem

    2015-01-01

    The aim of this study was to examine which child and family characteristics at the child's age of 2 years are determinants of development of self-care and mobility activities over a period of 2 years in young children with cerebral palsy (CP). Longitudinal data of 92 children, representing all level

  20. Determinants of developmental gain in daily activities in young children with cerebral palsy

    Kruijsen-Terpstra, Anne JA; Ketelaar, Marjolijn; Verschuren, Olaf; Smits, Dirk-Wouter; Jongmans, Marian J; Gorter, Jan Willem

    2015-01-01

    The aim of this study was to examine which child and family characteristics at the child's age of 2 years are determinants of development of self-care and mobility activities over a period of 2 years in young children with cerebral palsy (CP). Longitudinal data of 92 children, representing all level

  1. A novel 3-stage structure for a low-noise, high-gain and gain-flattened L-band erbium doped fiber amplifier

    强则煊; 何赛灵; 张徐亮; 沈林放

    2004-01-01

    The configuration of the novel three-stage L-band erbium-doped fiber amplifier with very large and flat gain and very low noise figure presented in this paper uses the forward ASE (amplified spontaneous emission) from the first section of the EDF (erbium-doped fiber) and the backward ASE from the third section of the EDF (both serve as the secondary pump sources of energy) to pump the second EDF. To improve the pump efficiency, the power of the pump is split into two parts (with a ratio of e.g. 2:7). The characteristics of this L-band EDFA are studied on the basis of the Giles Model with ASE.

  2. A novel 3-stage structure for a low-noise, high-gain and gain-flattened L-band erbium doped fiber amplifier

    强则煊; 何赛灵; 张徐亮; 沈林放

    2004-01-01

    The configuration of the novel three-stage L-band erbium-doped fiber amplifier with very large and flat gain and very low noise figure presented in this paper uses the forward ASE (amplified spontaneous emission) from the first section of the EDF (erbium-doped fiber) and the backward AS E from the third section of the EDF (both serve as the secondary pump sources of energy) to pump the second EDF. To improve the pump efficiency, the power of the pump is split into two parts(with a ratio of e.g. 2:7). The characteristics of this L-band EDFA are studied on the basis of the Giles Model with ASE.

  3. High Adherence to CPAP Treatment Does Not Prevent the Continuation of Weight Gain among Severely Obese OSAS Patients

    Myllylä, Minna; Kurki, Samu; Anttalainen, Ulla; Saaresranta, Tarja; Laitinen, Tarja

    2016-01-01

    Study Objectives: Obstructive sleep apnea syndrome (OSAS) patients benefit from continuous positive airway pressure (CPAP) treatment in a dose-response manner. We determined adherence and weight control, as well as their predictors, among long-term CPAP users. Methods: Cohort of 1,023 OSAS patients had used CPAP on average of 6.6 ± 1.2 years. BMI was determined at baseline and at follow-up visits. There were 7.4 ± 1.7 BMI and 6.5 ± 1.8 CPAP usage measurements per patient on average. Using the Bayesian hierarchical model, we determined the patients' individual trends of BMI and adherence development. Patients with significantly increasing or decreasing trends were identified at the posterior probability level of > 90%. Results: The mean age in the cohort was 55.6 ± 9.8 years, BMI 33.5 ± 6.4 kg/m2, apnea-hypopnea index 33.7 ± 23.1, and CPAP usage 6.0 ± 1.8 h/day. The majority of patients had no significant change in BMI (mean annual weight gain 0.04 ± 0.29 kg/m2) or CPAP adherence (mean annual increase 11.4 ± 7.0 min/day). However, at the individual level, 10% of the patients showed significant annual weight gain (0.63 ± 0.35 kg/m2) during the 5-year follow-up period. At baseline these patients were already more severely obese (mean BMI 40.0 ± 5.9 kg/m2) despite being younger (mean 50.9 ± 9.5 years) than the rest of the cohort. Conclusions: In the majority of CPAP-treated OSAS patients, weight did not significantly change but gained slightly slower than in age-matched population in general. However, in 10% of patients, high adherence to CPAP treatment did not prevent the continuation of weight gain. These patients present a high-risk group for OSAS-related multimorbidity later in life. Citation: Myllylä M, Kurki S, Anttalainen U, Saaresranta T, Laitinen T. High adherence to CPAP treatment does not prevent the continuation of weight gain among severely obese OSAS patients. J Clin Sleep Med 2016;12(4):519–528. PMID:26888588

  4. Cortical activation changes underlying stimulation-induced behavioural gains in chronic stroke.

    Stagg, Charlotte Jane; Bachtiar, Velicia; O'Shea, Jacinta; Allman, Claire; Bosnell, Rosemary Ann; Kischka, Udo; Matthews, Paul McMahan; Johansen-Berg, Heidi

    2012-01-01

    Transcranial direct current stimulation, a form of non-invasive brain stimulation, is showing increasing promise as an adjunct therapy in rehabilitation following stroke. However, although significant behavioural improvements have been reported in proof-of-principle studies, the underlying mechanisms are poorly understood. The rationale for transcranial direct current stimulation as therapy for stroke is that therapeutic stimulation paradigms increase activity in ipsilesional motor cortical areas, but this has not previously been directly tested for conventional electrode placements. This study was performed to test directly whether increases in ipsilesional cortical activation with transcranial direct current stimulation are associated with behavioural improvements in chronic stroke patients. Patients at least 6 months post-first stroke participated in a behavioural experiment (n = 13) or a functional magnetic resonance imaging experiment (n = 11), each investigating the effects of three stimulation conditions in separate sessions: anodal stimulation to the ipsilesional hemisphere; cathodal stimulation to the contralesional hemisphere; and sham stimulation. Anodal (facilitatory) stimulation to the ipsilesional hemisphere led to significant improvements (5-10%) in response times with the affected hand in both experiments. This improvement was associated with an increase in movement-related cortical activity in the stimulated primary motor cortex and functionally interconnected regions. Cathodal (inhibitory) stimulation to the contralesional hemisphere led to a functional improvement only when compared with sham stimulation. We show for the first time that the significant behavioural improvements produced by anodal stimulation to the ipsilesional hemisphere are associated with a functionally relevant increase in activity within the ipsilesional primary motor cortex in patients with a wide range of disabilities following stroke.

  5. Cortical activation changes underlying stimulation-induced behavioural gains in chronic stroke

    Stagg, Charlotte Jane; Bachtiar, Velicia; O'Shea, Jacinta; Allman, Claire; Bosnell, Rosemary Ann; Kischka, Udo; Matthews, Paul McMahan; Johansen-Berg, Heidi

    2011-01-01

    Transcranial direct current stimulation, a form of non-invasive brain stimulation, is showing increasing promise as an adjunct therapy in rehabilitation following stroke. However, although significant behavioural improvements have been reported in proof-of-principle studies, the underlying mechanisms are poorly understood. The rationale for transcranial direct current stimulation as therapy for stroke is that therapeutic stimulation paradigms increase activity in ipsilesional motor cortical a...

  6. The Development of a Digital Marketing Strategy to Gain Active Mobile Game Users in Japan

    Rönkkö, Makiyo

    2014-01-01

    Japan is the world’s biggest spender on mobile apps. This makes it an attractive market, but entering the Japan market is very difficult for Finnish mobile software developers. The goal of this thesis is to identify possible constraints that limit mobile game companies in the Japanese market, and analyze the means of increasing brand awareness and acquiring active game players. The focus is on finding the key elements required for building a digital marketing strategy targeted towards Japanes...

  7. Analog time-reversed ultrasonically encoded (TRUE) optical focusing inside scattering media with high power gain (Conference Presentation)

    Ma, Cheng; Xu, Xiao; Wang, Lihong V.

    2016-03-01

    Focusing light deep inside scattering media plays a key role in such biomedical applications as high resolution optical imaging, control, and therapy. In recent years, wavefront shaping technologies have come a long way in controlling light propagation in complex media. A prominent example is time-reversed ultrasonically encoded (TRUE) focusing, which allows noninvasive introduction of "guide stars" inside biological tissue to guide light focusing. By measuring the optical wavefront emanating from an ultrasound focus created at the target location, TRUE determines the desired wavefront non-iteratively, and achieves focusing at the target position via a subsequent optical time reversal. Compared to digital counterparts that employ slow electronic spatial light modulators and cameras, analog TRUE focusing relies on nonlinear photorefractive crystals that inherently accommodate more spatial modes and eliminate the troublesome alignment and data transfer required by digital approaches. However, analog TRUE focusing suffers from its small gain, defined as the energy or power ratio between the focusing and probing beams in the focal volume. Here, by implementing a modified analog TRUE focusing scheme that squeezes the duration of the time-reversed photon packet below the carrier-recombination-limited hologram decay time of the crystal, we demonstrated a photon flux amplification much greater than unity at a preset focal voxel in between two scattering layers. Although the energy gain was still below unity, the unprecedented power gain will nevertheless benefit new biomedical applications.

  8. General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats.

    Swithers, Susan E; Baker, Chelsea R; Davidson, T L

    2009-08-01

    In an earlier work (S. E. Swithers & T. L. Davidson, 2008), rats provided with a fixed amount of a yogurt diet mixed with saccharin gained more weight and showed impaired caloric compensation relative to rats given the same amount of yogurt mixed with glucose. The present 4 experiments examined the generality of these findings and demonstrated that increased body weight gain was also demonstrated when animals consumed a yogurt diet sweetened with an alternative high-intensity sweetener (acesulfame potassium; AceK) as well as in animals given a saccharin-sweetened base diet (refried beans) that was calorically similar but nutritionally distinct from low-fat yogurt. These studies also extended earlier findings by showing that body weight differences persist after saccharin-sweetened diets are discontinued and following a shift to a diet sweetened with glucose. In addition, rats first exposed to a diet sweetened with glucose still gain additional weight when subsequently exposed to a saccharin-sweetened diet. The results of these experiments add support to the hypothesis that exposure to weak or nonpredictive relationships between sweet tastes and caloric consequences may lead to positive energy balance.

  9. Time Is Money: The Decision Making of Smartphone High Users in Gain and Loss Intertemporal Choice

    Tang, Zixuan; Zhang, Huijun; Yan, An; Qu, Chen

    2017-01-01

    Nowadays the smartphone plays an important role in our lives. While it brings us convenience and efficiency, its overuse can cause problems. Although a great number of studies have demonstrated that people affected by substance abuse, pathological gambling, and internet addiction disorder have lower self-control than average, scarcely any study has investigated the decision making of smartphone high users by using a behavioral paradigm. The present study employed an intertemporal task, the Smartphone Addiction Inventory (SPAI) and the Barratt Impulsiveness Scale 11th version (BIS-11) to explore the decision control of smartphone high users in a sample of 125 college students. Participants were divided into three groups according to their SPAI scores. The upper third (69 or higher), middle third (from 61 to 68) and lower third (60 or lower) of scores were defined as high smartphone users, medium users and low users, respectively. We compared the percentage of small immediate reward/penalty choices in different conditions between the three groups. Relative to the low users group, high users and medium users were more inclined to request an immediate monetary reward. Moreover, for the two dimensions of time and money in intertemporal choice, high users and medium users showed a bias in intertemporal choice task among most of the time points and value magnitude compared to low users. These findings demonstrated that smartphone overuse was associated with problematic decision-making, a pattern similar to that seen in persons affected by a variety of addictions. PMID:28344568

  10. Subthreshold Schottky-barrier thin-film transistors with ultralow power and high intrinsic gain

    Lee, Sungsik; Nathan, Arokia

    2016-10-01

    The quest for low power becomes highly compelling in newly emerging application areas related to wearable devices in the Internet of Things. Here, we report on a Schottky-barrier indium-gallium-zinc-oxide thin-film transistor operating in the deep subthreshold regime (i.e., near the OFF state) at low supply voltages (400) that was both bias and geometry independent. The transistor reported here is useful for sensor interface circuits in wearable devices where high current sensitivity and ultralow power are vital for battery-less operation.

  11. Microwave control using a high-gain bias-free optoelectronic switch

    Freeman, J. L.; Ray, S.; West, D. L.; Thompson, A. G.; Lagasse, M. J.

    1991-08-01

    We describe an optoelectronic microwave switch that exploits the high optical sensitivity of the air-GaAs interface. With an optical power of 100 micro-W, the switch has an insertion loss of 3.4 dB and an isolation of greater than 20 dB from 0 to 10 GHz. No electrical power is needed.

  12. Energy gain and spectral tailoring of ion beams using ultra-high intensity laser beams

    Prasad, Rajendra; Swantusch, Marco; Cerchez, Mirela; Spickermann, Sven; Auorand, Bastian; Wowra, Thomas; Boeker, Juergen; Willi, Oswald

    2015-11-01

    The field of laser driven ion acceleration over the past decade has produced a huge amount of research. Nowadays, several multi-beam facilities with high rep rate system, e.g. ELI, are being developed across the world for different kinds of experiments. The study of interaction dynamics of multiple beams possessing ultra-high intensity and ultra-short pulse duration is of vital importance. Here, we present the first experimental results on ion acceleration using two ultra-high intensity beams. Thanks to the unique capability of Arcturus laser at HHU Düsseldorf, two almost identical, independent beams in laser parameters such as intensity (>1020 W/cm2), pulse duration (30 fs) and contrast (>1010), could be accessed. Both beams are focused onto a 5 μm thin Ti target. While ensuring spatial overlap of the two beams, at relative temporal delay of ~ 50 ps (optimum delay), the proton and carbon ion energies were enhanced by factor of 1.5. Moreover, strong modulation in C4+ions near the high energy cut-off is observed later than the optimum delay for the proton enhancement. This offers controlled tailoring of the spectral content of heavy ions.

  13. Simplification of Sun Tracking Mode to Gain High Concentration Solar Energy

    Omar Aliman

    2007-01-01

    Full Text Available Power conversion from solar thermal energy to electrical energy is still very cost-intensive. Serious effort has to be given in the development of the concentrator or heliostat structure expenditure which contributing the most expensive component in a central receiver solar power plant. With current development to find alternatives and lower down the capital, a new mode of sun tracking has been developed and feasibility tested. As it applies a single stage collector replacing conventional double stages structure, the new technique has significantly benefits use in high temperature and high concentration solar energy applications. Meanwhile, the stationary or fixed target (receiver offers more convenient working environment for various applications. Large and heavy solar powered Stirling Engine could be placed at the stationary location. On the other advantage offers by the new technique, the optical alignment was reasonably easier and less time consuming.

  14. Ultrahigh gain AlGaN/GaN high energy radiation detectors

    Howgate, J.D.; Schoell, S.J.; Schaefer, S.; Stutzmann, M.; Sharp, I.D. [Walter Schottky Institut and Physik Department, Technische Universitaet Muenchen, Am Coulombwall 4, 85748 Garching (Germany); Hofstetter, M.; Schmid, M.; Thalhammer, S. [Helmholtz Zentrum Muenchen, Ingolstaedter Landstrasse 1, 85764 Neuherberg (Germany); Zizak, I. [Helmholtz Zentrum Berlin, Albert-Einstein-Str. 15, 12489 Berlin (Germany); Hable, V.; Greubel, C.; Dollinger, G. [Institut fuer Angewandte Physik und Messtechnik LRT2, Werner-Heisenberg-Weg 39, 85577 Neubiberg (Germany)

    2012-08-15

    Due to its remarkable tolerance to high energy ionizing radiation, GaN has recently attracted attention as a promising material for dosimetry applications. However, materials issues that lead to persistent photoconductivity, poor sensitivity, and requirements for large operational voltages have been hurdles to realization of the full potential of this material. Here we demonstrate that the introduction of a two-dimensional electron gas channel, through the addition of AlGaN/GaN heterointerfaces, can be used to create intrinsic amplification of the number of electrons that can be collected from single ionization events, yielding exceptionally large sensitivities in ultralow dose rate regimes. Furthermore, anomalous photo-responses, which severely limit response times of GaN-based devices, can be eliminated using these heterostructures. Measurements using focused monochromatic synchrotron radiation at 1-20 keV, as well as focused 20 MeV protons, reveal that these devices provide the capability for high sensitivity and resolution real time monitoring, which is competitive with and complementary to state-of-the-art detectors. Therefore, AlGaN/GaN heterostructure devices are extremely promising for future applications in fields ranging from high energy physics to medical imaging. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  15. High-gain adaptive regulator for a string equation with uncertain harmonic disturbance under boundary output feedback control

    Baozhu GUO; Wei GUO

    2003-01-01

    This paper considers the boundary stabilization and parameter estimation of a one-dimensional wave equation in the case when one end is fixed and control and harmonic disturbance with uncertain amplitude are input at another end. A high-gain adaptive regulator is designed in terms of measured collocated end velocity. The existence and uniqueness of the classical solution of the closed-loop system is proven. It is shown that the state of the system approaches the standstill as time goes to infitv and meanwhile, the estimated parameter converges to the unknown parameter.

  16. Transverse and temporal characteristics of a high-gain free-electron laser in the saturation regime

    Huang Zhi Rong

    2002-01-01

    The transverse and the temporal characteristics of a high-gain free-electron laser are governed by refractive guiding and sideband instability, respectively. Using the self-consistent Vlasov-Maxwell equations, we explicitly determine the effective index of refraction and the guided radiation mode for an electron beam with arbitrary transverse size. Electrons trapped by the guided radiation execute synchrotron oscillation and hence are susceptible to the sideband instability. We explain the spectral evolution and determine the sideband growth rate. These theoretical predictions agree well with GINGER simulation results.

  17. Results of innovative communication processes on productivity gains in a high technology environment

    Kelly, B. J.

    1985-01-01

    The technology which resulted in performance breakthroughs at engineering and management services is discussed. As a result of the innovative approaches of communicating productivity concepts to the employees, specific outcomes can now be pinpointed at all levels of the organization such as: (1) employee-headed program; (2) performance feedback processes; and (3) an investigative approach to creating leadership. The Lockheed Corporation began the innovative trend in 1974 when they became the first company to introduce quality circles in America. Although some of Lockheed-EMSCO's processes may sound different from traditional improvement processes, the context out of which those to be presented evolved has sustained more than 10 years of positive results through employee involvement activities.

  18. Novel Interleaved Converter with Extra-High Voltage Gain to Process Low-Voltage Renewable-Energy Generation

    Chih-Lung Shen

    2016-10-01

    Full Text Available This paper presents a novel interleaved converter (NIC with extra-high voltage gain to process the power of low-voltage renewable-energy generators such as photovoltaic (PV panel, wind turbine, and fuel cells. The NIC can boost a low input voltage to a much higher voltage level to inject renewable energy to DC bus for grid applications. Since the NIC has two circuit branches in parallel at frond end to share input current, it is suitable for high power applications. In addition, the NIC is controlled in an interleaving pattern, which has the advantages that the NIC has lower input current ripple, and the frequency of the ripple is twice the switching frequency. Two coupled inductors and two switched capacitors are incorporated to achieve a much higher voltage gain than conventional high step-up converters. The proposed NIC has intrinsic features such as leakage energy totally recycling and low voltage stress on power semiconductor. Thorough theoretical analysis and key parameter design are presented in this paper. A prototype is built for practical measurements to validate the proposed NIC.

  19. Yield gains of coffee plants from phosphorus fertilization may not be generalized for high density planting

    Samuel Vasconcelos Valadares

    2014-06-01

    Full Text Available Inconclusive responses of the adult coffee plant to phosphorus fertilization have been reported in the literature, especially when dealing with application of this nutrient in high density planting systems. Thus, this study was carried out for the purpose of assessing the response of adult coffee plants at high planting density in full production (in regard to yield and their biennial cycle/stability to the addition of different sources and application rates of P in the Zona da Mata region of Minas Gerais, Brazil. The experiment with coffee plants of the Catucaí Amarelo 6/30 variety was carried out over four growing seasons. Treatments were arranged in a full factorial design [(4 × 3 + 1] consisting of four P sources (monoammonium phosphate, simple superphosphate, natural reactive rock phosphate from Algeria (Djebel-Onk, and FH 550®, three P rates (100, 200, and 400 kg ha-1 year-1 of P2O5, and an additional treatment without application of the nutrient (0 kg ha-¹ year-¹. A randomized block experimental design was used with three replicates. The four seasons were evaluated as subplots in a split plot experiment. The P contents in soil and leaves increased with increased rates of P application. However, there was no effect from P application on the yield and its biennial cycle/stability regardless of the source used over the four seasons assessed.

  20. Levamisole: A positive allosteric modulator for the α3β4 nicotinic acetylcholine receptors prevents weight gain in CD-1 mice on a high fat diet.

    Lewis, Jeanne A; Yakel, Jerrel L; Pandya, Anshul A

    2016-12-01

    Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the function of multiple neurotransmitter pathways throughout the central nervous system. This includes nAChRs found on the proopiomelanocortin neurons in the hypothalamus. Activation of these nAChRs by nicotine causes a decrease in consumption of food in rodents. In this study, we tested the effect of subtype selective allosteric modulators for nAChRs on the body weight of CD-1 mice. Levamisole, an allosteric modulator for the α3β4 subtype of nAChRs, prevented weight gain in mice that were fed a high fat diet. PNU-120596 and desformylflustrabromine are selective PAMs for the α7 and α4β2 nAChR, respectively. Both of these compounds failed to prevent weight gain in CD-1 mice. These results suggest that modulation of hypothalamic α3β4 nAChRs is an important factor in regulating food intake, and the PAMs for these receptors need further investigation as potential therapeutic agents for controlling weight gain.

  1. A High-Gain Passive UHF-RFID Tag with Increased Read Range

    Simone Zuffanelli

    2016-07-01

    Full Text Available In this work, a passive ultra-high frequency radio-frequency identification UHF-RFID tag based on a 1.25 wavelengths thin dipole antenna is presented for the first time. The length of the antenna is properly chosen in order to maximize the tag read range, while maintaining a reasonable tag size and radiation pattern. The antenna is matched to the RFID chip by means of a very simple matching network based on a shunt inductance. A tag prototype, based on the Alien Higgs-3 chip, is designed and fabricated. The overall dimensions are 400 mm × 14.6 mm, but the tag width for most of its length is delimited by the wire diameter (0.8 mm. The measured read range exhibits a maximum value of 17.5 m at the 902–928 MHz frequency band. This represents an important improvement over state-of-the-art passive UHF-RFID tags.

  2. A High-Gain Passive UHF-RFID Tag with Increased Read Range

    Zuffanelli, Simone; Aguila, Pau; Zamora, Gerard; Paredes, Ferran; Martin, Ferran; Bonache, Jordi

    2016-01-01

    In this work, a passive ultra-high frequency radio-frequency identification UHF-RFID tag based on a 1.25 wavelengths thin dipole antenna is presented for the first time. The length of the antenna is properly chosen in order to maximize the tag read range, while maintaining a reasonable tag size and radiation pattern. The antenna is matched to the RFID chip by means of a very simple matching network based on a shunt inductance. A tag prototype, based on the Alien Higgs-3 chip, is designed and fabricated. The overall dimensions are 400 mm × 14.6 mm, but the tag width for most of its length is delimited by the wire diameter (0.8 mm). The measured read range exhibits a maximum value of 17.5 m at the 902–928 MHz frequency band. This represents an important improvement over state-of-the-art passive UHF-RFID tags. PMID:27455274

  3. Sensitivity gains, linearity, and spectral reproducibility in nonuniformly sampled multidimensional MAS NMR spectra of high dynamic range

    Suiter, Christopher L.; Paramasivam, Sivakumar; Hou, Guangjin; Sun, Shangjin; Rice, David; Hoch, Jeffrey C.; Rovnyak, David

    2014-01-01

    Recently, we have demonstrated that considerable inherent sensitivity gains are attained in MAS NMR spectra acquired by nonuniform sampling (NUS) and introduced maximum entropy interpolation (MINT) processing that assures the linearity of transformation between the time and frequency domains. In this report, we examine the utility of the NUS/MINT approach in multidimensional datasets possessing high dynamic range, such as homonuclear 13C–13C correlation spectra. We demonstrate on model compounds and on 1–73-(U-13C, 15N)/74–108-(U-15N) E. coli thioredoxin reassembly, that with appropriately constructed 50 % NUS schedules inherent sensitivity gains of 1.7–2.1-fold are readily reached in such datasets. We show that both linearity and line width are retained under these experimental conditions throughout the entire dynamic range of the signals. Furthermore, we demonstrate that the reproducibility of the peak intensities is excellent in the NUS/MINT approach when experiments are repeated multiple times and identical experimental and processing conditions are employed. Finally, we discuss the principles for design and implementation of random exponentially biased NUS sampling schedules for homonuclear 13C–13C MAS correlation experiments that yield high-quality artifact-free datasets. PMID:24752819

  4. Sensitivity Gains, Linearity, and Spectral Reproducibility in Nonuniformly Sampled Multidimensional MAS NMR Spectra of High Dynamic Range.

    Suiter, Christopher L.; Paramasivam, Sivakumar; Hou, Guangjin; Sun, Shangjin; Rice, David M.; Hoch, Jeffrey C.; Rovnyak, David S.; Polenova, Tatyana E.

    2014-04-22

    Recently, we have demonstrated that considerable inherent sensitivity gains are attained in MAS NMR spectra acquired by nonuniform sampling (NUS) and introduced maximum entropy interpolation (MINT) processing that assures the linearity of transformation between the time and frequency domains. In this report, we examine the utility of the NUS/MINT approach in multidimensional datasets possessing high dynamic range, such as homonuclear 13C–13C correlation spectra. We demonstrate on model compounds and on 1–73-(U-13C,15N)/74–108-(U-15N) E. coli thioredoxin reassembly, that with appropriately constructed 50 % NUS schedules inherent sensitivity gains of 1.7–2.1-fold are readily reached in such datasets. We show that both linearity and line width are retained under these experimental conditions throughout the entire dynamic range of the signals. Furthermore, we demonstrate that the reproducibility of the peak intensities is excellent in the NUS/MINT approach when experiments are repeated multiple times and identical experimental and processing conditions are employed. Finally, we discuss the principles for design and implementation of random exponentially biased NUS sampling schedules for homonuclear 13C–13C MAS correlation experiments that yield high quality artifact-free datasets.

  5. Semi-global robust output regulation of minimum-phase nonlinear systems based on high-gain nonlinear internal model

    Wei, Xile; Lu, Meili; Wang, Jiang; Tsang, K. M.; Deng, Bin; Che, Yanqiu

    2010-05-01

    We consider the assumption of existence of the general nonlinear internal model that is introduced in the design of robust output regulators for a class of minimum-phase nonlinear systems with rth degree (r ≥ 2). The robust output regulation problem can be converted into a robust stabilisation problem of an augmented system consisting of the given plant and a high-gain nonlinear internal model, perfectly reproducing the bounded including not only periodic but also nonperiodic exogenous signal from a nonlinear system, which satisfies some general immersion assumption. The state feedback controller is designed to guarantee the asymptotic convergence of system errors to zero manifold. Furthermore, the proposed scheme makes use of output feedback dynamic controller that only processes information from the regulated output error by using high-gain observer to robustly estimate the derivatives of the regulated output error. The stabilisation analysis of the resulting closed-loop systems leads to regional as well as semi-global robust output regulation achieved for some appointed initial condition in the state space, for all possible values of the uncertain parameter vector and the exogenous signal, ranging over an arbitrary compact set.

  6. Gain control of gamma frequency activation by a novel feed forward disinhibitory loop: implications for normal and epileptic neural activity

    Zeinab eBirjandian

    2013-11-01

    Full Text Available The inhibition of excitatory (pyramidal neurons directly dampens their activity resulting in a suppression of neural network output. The inhibition of inhibitory cells is more complex. Inhibitory drive is known to gate neural network synchrony, but there is also a widely held view that it may augment excitability by reducing inhibitory cell activity, a process termed disinhibition. Surprisingly, however, disinhibition has never been demonstrated to be an important mechanism that augments or drives the activity of excitatory neurons in a functioning neural circuit. Using voltage sensitive dye imaging (VSDI we show that 20-80 Hz stimulus trains, (beta-gamma activation, of the olfactory cortex pyramidal cells in layer II leads to a subsequent reduction in inhibitory interneuron activity that augments the efficacy of the initial stimulus. This disinhibition occurs with a lag of about 150-250 ms after the initial excitation of the layer 2 pyramidal cell layer. In addition activation of the endopiriform nucleus also arises just before the disinhibitory phase with a lag of about 40-80 ms. Preventing the spread of action potentials from layer II stopped the excitation of the endopiriform nucleus, abolished the disinhibitory activity and reduced the excitation of layer II cells. After the induction of experimental epilepsy the disinhibition was more intense with a concomitant increase in excitatory cell activity. Our observations provide the first evidence of feed forward disinhibition loop that augments excitatory neurotransmission, a mechanism that could play an important role in the development of epileptic seizures.

  7. Gain-of-function Lyn induces anemia: appropriate Lyn activity is essential for normal erythropoiesis and Epo receptor signaling.

    Slavova-Azmanova, Neli S; Kucera, Nicole; Satiaputra, Jiulia; Stone, Leah; Magno, Aaron; Maxwell, Mhairi J; Quilici, Cathy; Erber, Wendy; Klinken, S Peter; Hibbs, Margaret L; Ingley, Evan

    2013-07-11

    Lyn is involved in erythropoietin (Epo)-receptor signaling and erythroid homeostasis. Downstream pathways influenced following Lyn activation and their significance to erythropoiesis remain unclear. To address this, we assessed a gain-of-function Lyn mutation (Lyn(up/up)) on erythropoiesis and Epo receptor signaling. Adult Lyn(up/up) mice were anemic, with dysmorphic red cells (spherocyte-like, acanthocytes) in their circulation, indicative of hemolytic anemia and resembling the human disorder chorea acanthocytosis. Heterozygous Lyn(+/up) mice became increasingly anemic with age, indicating that the mutation was dominant. In an attempt to overcome this anemia, extramedullary erythropoiesis was activated. As the mice aged, the levels of different immature erythroid populations changed, indicating compensatory mechanisms to produce more erythrocytes were dynamic. Changes in Epo signaling were observed in Lyn(+/up) erythroid cell lines and primary CD71(+) Lyn(up/up) erythroblasts, including significant alterations to the phosphorylation of Lyn, the Epo receptor, Janus kinase 2, Signal Transducer and Action of Transcription-5, GRB2-associated-binding protein-2, Akt, and Forkhead box O3. As a consequence of altered Lyn signaling, Lyn(+/up) cells remained viable in the absence of Epo but displayed delayed Epo-induced differentiation. These data demonstrate that Lyn gene dosage and activity are critical for normal erythropoiesis; constitutively active Lyn alters Epo signaling, which in turn produces erythroid defects.

  8. Caffeine prevents weight gain and cognitive impairment caused by a high-fat diet while elevating hippocampal BDNF.

    Moy, Gregory A; McNay, Ewan C

    2013-01-17

    Obesity, high-fat diets, and subsequent type 2 diabetes (T2DM) are associated with cognitive impairment. Moreover, T2DM increases the risk of Alzheimer's disease (AD) and leads to abnormal elevation of brain beta-amyloid levels, one of the hallmarks of AD. The psychoactive alkaloid caffeine has been shown to have therapeutic potential in AD but the central impact of caffeine has not been well-studied in the context of a high-fat diet. Here we investigated the impact of caffeine administration on metabolism and cognitive performance, both in control rats and in rats placed on a high-fat diet. The effects of caffeine were significant: caffeine both (i) prevented the weight-gain associated with the high-fat diet and (ii) prevented cognitive impairment. Caffeine did not alter hippocampal metabolism or insulin signaling, likely because the high-fat-fed animals did not develop full-blown diabetes; however, caffeine did prevent or reverse a decrease in hippocampal brain-derived neurotrophic factor (BDNF) seen in high-fat-fed animals. These data confirm that caffeine may serve as a neuroprotective agent against cognitive impairment caused by obesity and/or a high-fat diet. Increased hippocampal BDNF following caffeine administration could explain, at least in part, the effects of caffeine on cognition and metabolism.

  9. [ICF and social medicine evaluation of capability of gainful activity: is everything clear?--a discussion article].

    Körner, M

    2005-08-01

    The ICF (International Classification of Functioning, Disability and Health) calls attention to the complexities associated with disturbances of health. The question raised is how the various constituents and the resulting network as defined by this Classification can gain importance for medical expertise under the statutory pension insurance scheme concerning work-related capacity. Possible variations of strategy are discussed: clinical intuition, algorithmic pathways, proved medical diagnostics, particular diagnostics of activity according to ICF. A genuine "silver bullet" is not in evidence thus far. It cannot be expected that diagnostics relating to a certain sector of the ICF will basically eclipse the rest. Future standards of medical expertise should specify as clearly as possible the impact of the diverse diagnostic findings on the assessment of work-related capacity. Framing emphasis in this way cannot be performed by the ICF on its own.

  10. Spectral Analysis of Quantum-Dash Lasers: Effect of Inhomogeneous Broadening of the Active-Gain Region

    Khan, Mohammed Zahed Mustafa

    2012-05-01

    The effect of the active region inhomogeneity on the spectral characteristics of InAs/InP quantum-dash (Qdash) lasers is examined theoretically by solving the coupled set of carrier-photon rate equations. The inhomogeneity due to dash size or composition fluctuation is included in the model by considering dispersive energy states and characterized by a Gaussian envelope. In addition, the technique incorporates multilongitudinal photon modes and homogeneous broadening of the optical gain. The results predict a red shift in the central lasing wavelength of Qdash lasers on increasing the inhomogeneous broadening either explicitly or implicitly, which supports various experimental observations. The threshold current density and the lasing bandwidth are also found to increase. © 2012 IEEE.

  11. Laser propagation through full-scale, high-gain MagLIF gas pipes using the NIF

    Pollock, Bradley; Sefkow, Adam; Goyon, Clement; Strozzi, David; Khan, Shahab; Rosen, Mordy; Campbell, Mike; Logan, Grant; Peterson, Kyle; Moody, John

    2016-10-01

    The first relevant measurements of laser propagation through surrogate high-gain MagLIF gas pipe targets at full scale have been performed at the NIF, using 30 kJ of laser drive from one quad in a 10 ns pulse at an intensity of 2e14 W/cm2. The unmagnetized pipe is filled with 1 atm of 99%/1% neopentane/Ar, and uses an entrance window of 0.75 um polyimide and an exit window of 0.3 um of Ta backed with 5 um of polyimide. Side-on x-ray emission from the plasma is imaged through the 100 um-thick epoxy wall onto a framing camera at four times during the drive, and is in excellent agreement with pre-shot HYDRA radiation-hydrodynamics modeling. X-ray emission from the Ta exit plane is imaged onto a streak camera to determine the timing and intensity of the laser burning through the pipe, and the Ar emission from the center of the pipe is spectrally- and temporally-resolved to determine the plasma electron temperature. Backscatter is measured throughout the laser drive, and is found to be of significance only when the laser reaches the Ta exit plane and produces SBS. These first results in unmagnetized surrogate gas fills are encouraging since they demonstrate sufficient laser energy absorption and low LPI losses within high-density long-scale-length plasmas for proposed high-gain MagLIF target designs. We will discuss plans to magnetize targets filled with high-density DT gas in future experiments. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the National Nuclear Security Administration under Contract No. DE-AC04-94AL85000.

  12. The effects of acute stress exposure on striatal activity during Pavlovian conditioning with monetary gains and losses.

    Lewis, Andrea H; Porcelli, Anthony J; Delgado, Mauricio R

    2014-01-01

    Pavlovian conditioning involves the association of an inherently neutral stimulus with an appetitive or aversive outcome, such that the neutral stimulus itself acquires reinforcing properties. Across species, this type of learning has been shown to involve subcortical brain regions such as the striatum and the amygdala. It is less clear, however, how the neural circuitry involved in the acquisition of Pavlovian contingencies in humans, particularly in the striatum, is affected by acute stress. In the current study, we investigate the effect of acute stress exposure on Pavlovian conditioning using monetary reinforcers. Participants underwent a partial reinforcement conditioning procedure in which neutral stimuli were paired with high and low magnitude monetary gains and losses. A between-subjects design was used, such that half of the participants were exposed to cold stress while the remaining participants were exposed to a no stress control procedure. Cortisol measurements and subjective ratings were used as measures of stress. We observed an interaction between stress, valence, and magnitude in the ventral striatum, with the peak in the putamen. More specifically, the stress group exhibited an increased sensitivity to magnitude in the gain domain. This effect was driven by those participants who experienced a larger increase in circulating cortisol levels in response to the stress manipulation. Taken together, these results suggest that acute stress can lead to individual differences in circulating cortisol levels which influence the striatum during Pavlovian conditioning with monetary reinforcers.

  13. A new design methodology of obtaining wide band high gain broadband parametric source for infrared wavelength applications

    Maji, Partha Sona; Roy Chaudhuri, Partha

    2016-03-01

    In this article, we have presented a new design methodology of obtaining wide band parametric sources based on highly nonlinear chalcogenide material of As2S3. The dispersion profile of the photonic crystal fiber (PCF) has been engineered wisely by reducing the diameter of the second air-hole ring to have a favorable higher order dispersion parameter. The parametric gain dependence upon fiber length, pump power, and different pumping wavelengths has been investigated in detail. Based upon the nonlinear four wave mixing phenomenon, we are able to achieve a wideband parametric amplifier with peak gain of 29 dB with FWHM of ≈2000 nm around the IR wavelength by proper tailoring of the dispersion profile of the PCF with a continuous wave Erbium (Er3+)-doped ZBLAN fiber laser emitting at 2.8 μm as the pump source with an average power of 5 W. The new design methodology will unleash a new dimension to the chalcogenide material based investigation for wavelength translation around IR wavelength band.

  14. Parameter Analysis For A High-Gain Harmonic Generation FEL By Numerical Calculation Based On 1D Theory

    Li, Yuhui; Zhang, Shancai

    2004-01-01

    The high-gain harmonic generation (HGHG) free-electron laser (FEL) is an important candidate for a fourth-generation light source. Lots of theoretical work has been performed. Recently a further 1D theory about HGHG FEL has been developed. It considers the effects of different parameters for the whole process. An initial program based on this theory has been made. In this paper, a brief comparison of the results from this 1D program and from TDA (3D code) is discussed. It also analyses the parameters for Shanghai deep ultra violate free-electron laser source (SDUV-FEL), including electron beam energy spread, seed laser power, strength of dispersion section etc.

  15. Modeling and output tracking of transverse flux permanent magnet machines using high gain observer and RBF neural network.

    Karimi, H R; Babazadeh, A

    2005-10-01

    This paper deals with modeling and adaptive output tracking of a transverse flux permanent magnet machine as a nonlinear system with unknown nonlinearities by utilizing high gain observer and radial basis function networks. The proposed model is developed based on computing the permeance between rotor and stator using quasiflux tubes. Based on this model, the techniques of feedback linearization and Hinfinity control are used to design an adaptive control law for compensating the unknown nonlinear parts, such as the effect of cogging torque, as a disturbance is decreased onto the rotor angle and angular velocity tracking performances. Finally, the capability of the proposed method in tracking both the angle and the angular velocity is shown in the simulation results.

  16. Gimbals Drive and Control Electronics Design, Development and Testing of the LRO High Gain Antenna and Solar Array Systems

    Chernyakov, Boris; Thakore, Kamal

    2010-01-01

    Launched June 18, 2009 on an Atlas V rocket, NASA's Lunar Reconnaissance Orbiter (LRO) is the first step in NASA's Vision for Space Exploration program and for a human return to the Moon. The spacecraft (SC) carries a wide variety of scientific instruments and provides an extraordinary opportunity to study the lunar landscape at resolutions and over time scales never achieved before. The spacecraft systems are designed to enable achievement of LRO's mission requirements. To that end, LRO's mechanical system employed two two-axis gimbal assemblies used to drive the deployment and articulation of the Solar Array System (SAS) and the High Gain Antenna System (HGAS). This paper describes the design, development, integration, and testing of Gimbal Control Electronics (GCE) and Actuators for both the HGAS and SAS systems, as well as flight testing during the on-orbit commissioning phase and lessons learned.

  17. Transmission Enhancement of High-$k$ Waves through Metal-InGaAsP Multilayers Calculated via Scattering Matrix Method with Semi-Classical Optical Gain

    Smalley, Joseph S T; Shahin, Shiva; Kanté, Boubacar; Fainman, Yeshaiahu

    2015-01-01

    We analyze the steady-state transmission of high-momentum (high-$k$) electromagnetic waves through metal-semiconductor multilayer systems with loss and gain in the near-infrared (NIR). Using a semi-classical optical gain model in conjunction with the scattering matrix method (SMM), we study indium gallium arsenide phosphide (InGaAsP) quantum wells as the active semiconductor, in combination with the metals, aluminum-doped zinc oxide (AZO) and silver (Ag). Under moderate external pumping levels, we find that NIR transmission through Ag/InGaAsP systems may be enhanced by several orders of magnitude relative to the unpumped case, over a large angular and frequency bandwidth. Conversely, transmission enhancement through AZO/InGaAsP systems is orders of magnitude smaller, and has a strong frequency dependence. We discuss the relative importance of Purcell enhancement on our results and validate analytical calculations based on the SMM with numerical finite-difference time domain simulations.

  18. Fabrication and materials for magneto-photonic assemblies for high-gain antenna applications at GHz frequencies

    Zhang, Lanlin

    Recent magnetic photonic assembly (MPA) designs for high-gain antennas contain arrays of low-loss, anisotropic dielectrics and ferrimagnetic materials. Anisotropic dielectrics (AD) are fabricated from laminates, which consist of two ceramics with largely different permittivity and low dielectric losses at GHz frequencies. High gain has been demonstrated in a prototype antenna with 2 sets of 3 mutually rotated AD layers. These layers were made from laminates of commercially available alpha-Al2O3 and Nd-doped barium titanate. Equivalent permittivity tensors and loss tangents (tan delta˜1.9x10-3) were characterized using a resonant cavity based approach, coupled with a finite-element method (FEM) full-wave solver. To enable further minimization of dielectric loss (tan delta), dense high-purity alpha-Al2O3 and TiO2 were prepared starting from colloidally stabilizing the powders in aqueous HNO3 or NH3. After colloidal filtration and sintering, alpha-Al 2O3 with >97.9% density was achieved at a sintering temperature of 1300°C, and TiO2 with >99.5% density was obtained at 1000°C. These low sintering temperatures are ascribed to excellent compact homogeneity. TiO2 was obtained with tan delta of 1.4x10-4 at 6.4 GHz at room temperature. This relatively low value is attributed to the homogeneous dense microstructure with 2.2 mum grain size. Al 3+ was doped into TiO2 using a modified infiltration method to compensate for the effect of Ti4+ reduction. A homogeneous microstructure and doping concentration were also observed in the doped dense TiO2. Substituted Y3Fe5O12 (YIG) garnet was chosen as the ferrimagnetic (F) component, due to its pronounced Faraday rotation effect and potentially low magnetic and dielectric loss. Phase pure garnet was prepared by using the citric-gel method. The magnetic properties were studied for Ca,V,Zr-substituted YIG (CVZG) and as-prepared particle morphology. Compacts of CVZG submicron particles were found to possess a low loss at GHz

  19. Submonolayer InGaAs/GaAs quantum-dot lasers with high modal gain and zero-linewidth enhancement factor

    Xu, Zhangcheng; Birkedal, Dan; Juhl, Michael

    2004-01-01

    The gain spectra of a submonolayer (SML) InGaAs/GaAs quantum dot (QD) laser working at 30°C were measured using the Hakki–Paoli method. It is found that the maximum modal gain of QD ground states is as high as 44 cm–1 and no gain saturation occurs below the threshold at the lasing wavelength of 964.......1 nm. When the injection current is about 0.98 times the threshold, the gain spectrum becomes symmetric with respect to the lasing wavelength, and zero-linewidth enhancement factor is observed. These properties are attributed to the high density and the high uniformity of SML QDs in our laser diode....

  20. Ultra-high, broadband gain in a lattice-engineered, Yb-doped double tungstate channel waveguide

    Geskus, D.; Aravazhi, S.; Bernhardi, E.H.; Agazzi, L.; García-Blanco, S.M.; Pollnau, M.

    2012-01-01

    150 dB/cm gain over 55 nm wavelength range between 977-1032 nm is obtained in a 47.5% Yb-doped potassium double tungstate waveguide amplifier. The dependence of luminescence lifetime and gain on Yb concentration is investigated.

  1. An indirect flat-panel detector with avalanche gain for low dose x-ray imaging: SAPHIRE (scintillator avalanche photoconductor with high resolution emitter readout)

    Zhao, Wei; Li, Dan; Rowlands, J. A.; Egami, N.; Takiguchi, Y.; Nanba, M.; Honda, Y.; Ohkawa, Y.; Kubota, M.; Tanioka, K.; Suzuki, K.; Kawai, T.

    2008-03-01

    An indirect flat-imager with programmable avalanche gain and field emitter array (FEA) readout is being investigated for low-dose x-ray imaging with high resolution. It is made by optically coupling a structured x-ray scintillator CsI (Tl) to an amorphous selenium (a-Se) avalanche photoconductor called HARP (high-gain avalanche rushing photoconductor). The charge image created by HARP is read out by electron beams generated by the FEA. The proposed detector is called SAPHIRE (Scintillator Avalanche Photoconductor with HIgh Resolution Emitter readout). The avalanche gain of HARP depends on both a-Se thickness and applied electric field E Se. At E Se of > 80 V/μm, the avalanche gain can enhance the signal at low dose (e.g. fluoroscopy) and make the detector x-ray quantum noise limited down to a single x-ray photon. At high exposure (e.g. radiography), the avalanche gain can be turned off by decreasing E Se to < 70 V/μm. In this paper the imaging characteristics of the FEA readout method, including the spatial resolution and noise, were investigated experimentally using a prototype optical HARP-FEA image sensor. The potential x-ray imaging performance of SAPHIRE, especially the aspect of programmable gain to ensure wide dynamic range and x-ray quantum noise limited performance at the lowest exposure in fluoroscopy, was investigated.

  2. Double-pass high-gain low-noise EDFA over S- and C+L-bands by tunable fundamental-mode leakage loss.

    Hung, Chi-Ming; Chen, Nan-Kuang; Lai, Yinchieh; Chi, Sien

    2007-02-19

    We demonstrate a high-gain low-noise double-pass tunable EDFA over S- and C+L-bands by discretely introducing fundamental-mode leakage loss in a 16-m-long standard C-band Er(3+)-doped fiber. The amplified spontaneous emission at the wavelengths of longer than 1530 nm can be substantially attenuated by the ASE suppressing filters to maintain high population inversion and to squeeze out the optical gain for S-band signals. When the filters are disabled, the gain bandwidth immediately returns back to the C+L-bands. Under S-band operation, a 37 dB small signal gain and a minimum 4.84 dB noise figure at 1486.9 nm are achieved with a 980 nm pump power of 154 mW.

  3. Very high-gain and low-excess noise near-infrared single-photon avalanche detector: an NIR solid state photomultiplier

    Linga, Krishna; Yevtukhov, Yuriy; Liang, Bing

    2009-05-01

    A new family of photodetectors with a Discrete Amplification (DA) mechanism allows the realization of very high gain and low excess noise factor in the visible and near infrared spectral regions and offers an alternative to conventional photomultiplier tubes and Geiger mode avalanche photodetectors. These photodetectors can operate in linear detection mode with gain-bandwidth product in excess of 4X1014 and in photon counting mode with count rates up to 108 counts/sec. Potential benefits of this technology over conventional avalanche photodetectors include ultra low excess noise factor, very high gain, and lower reset time (photodetectors in the near infrared wavelength range. The measured devices have the following performance characteristics: gain > 2X105, excess noise factor Lidar, quantum cryptography, night vision and other military, defence and aerospace applications.

  4. Parameter analysis for a high-gain harmonic generation FEL using a recently developed 3D polychromatic code

    Biedron, S G; Yu, L H

    2000-01-01

    One possible design for a fourth-generation light source is the high-gain harmonic generation (HGHG) free-electron laser (FEL). Here, a coherent seed with a wavelength at a subharmonic of the desired output radiation interacts with the electron beam in an energy-modulating section. This energy modulation is then converted into spatial bunching while traversing a dispersive section (a three-dipole chicane). The final step is passage through an undulator tuned to the desired higher harmonic output wavelength. The coherent seed serves to suppress and can be at a much lower subharmonic of the output radiation. Recently, a 3D code that includes multiple frequencies, multiple undulators (both in quantity and/or type), quadrupole magnets, and dipole magnets was developed to easily simulate HGHG. Here, a brief review of the HGHG theory, the code development, the Accelerator Test Facility's (ATF) HGHG FEL experimental parameters, and the parameter analysis from simulations of this specific experiment will be discussed...

  5. Inhibitory effects of Leonurus sibiricus on weight gain after menopause in ovariectomized and high-fat diet-fed mice.

    Kim, Jangseon; Kim, Mi Hye; Choi, You Yeon; Hong, Jongki; Yang, Woong Mo

    2016-07-01

    Leonurus sibiricus, also called motherwort, is a well-known functional food and medicinal herb. It has been known to possess beneficial properties for women's health, especially for aged women. Estrogen deficiency in the menopause could induce lipid metabolic abnormalities in body fat, resulting in obesity. In this study, the inhibitory effects of L. sibiricus on obesity after the menopause were investigated. Female C57BL/6 mice were ovariectomized and fed high-fat diet (HFD) for 12 weeks. Following an induction period, aqueous extracts of L. sibiricus (LS) were orally administrated for 6 weeks. The body, uterine, and visceral fat weights were measured immediately after the animals were killed. Histological analysis was performed to monitor fat and liver. Serum levels of glucose, triglyceride, total cholesterol, and LDL-cholesterol were evaluated. In addition, the expression of lipases was analyzed. Total body weight was significantly decreased by LS treatment. Histological changes in adipocyte size were shown along with a decrease of visceral fat weight in the LS-treated group. In addition, the fat infiltration of liver was reduced by LS administration. LS-treated mice experienced decreases of serum triglyceride, total cholesterol, and LDL-cholesterol levels. The expression of HSL and ATGL was significantly increased by LS treatment. These results suggest that LS could regulate the lipid metabolism via an increase of lipases expression in ovariectomized and HFD-fed mice. LS might be a novel candidate for a functional food to inhibit weight gain after the menopause.

  6. Sensor fault detection and isolation via high-gain observers: application to a double-pipe heat exchanger.

    Escobar, R F; Astorga-Zaragoza, C M; Téllez-Anguiano, A C; Juárez-Romero, D; Hernández, J A; Guerrero-Ramírez, G V

    2011-07-01

    This paper deals with fault detection and isolation (FDI) in sensors applied to a concentric-pipe counter-flow heat exchanger. The proposed FDI is based on the analytical redundancy implementing nonlinear high-gain observers which are used to generate residuals when a sensor fault is presented (as software sensors). By evaluating the generated residual, it is possible to switch between the sensor and the observer when a failure is detected. Experiments in a heat exchanger pilot validate the effectiveness of the approach. The FDI technique is easy to implement allowing the industries to have an excellent alternative tool to keep their heat transfer process under supervision. The main contribution of this work is based on a dynamic model with heat transfer coefficients which depend on temperature and flow used to estimate the output temperatures of a heat exchanger. This model provides a satisfactory approximation of the states of the heat exchanger in order to allow its implementation in a FDI system used to perform supervision tasks.

  7. Fuzzy PI Controller Based Fault Analysis and Recovery in Sensorless BLDC Motor using High Gain Hybrid Converter (HGHC

    R. Jayanthi

    2014-12-01

    Full Text Available Renewable Energy Sources (RES has been widely used in various applications due to increase in power demand. In this study, a High Gain Hybrid Converter (HGHC has been used to utilize maximum power from PV panel and to control the battery mode of operation such as charging/discharging in an efficient manner. In the load side, sensor less BLDC motor has been used in this study. After the back EMF is generated in the load side BLDC motor, it is taken as feedback to the HGHC. So, this will act as the main supply and thus, more power can be saved. Moreover, this research study also focuses on the transient analysis of the BLDC motor. The inverter in BLDC motor plays a vital role as it is responsible for flux generation and fixing up of angle ‘θ’ to the motor for its operation. So, the failures in the switches of the inverter would greatly affect the overall functioning of the BLDC motor. Thus, this research study focuses on the failure analysis of these switches in the inverter. In order to analyze and recover these faults, error controllers have been used in this proposed study. The simulations are carried out in MATLAB r2011a and the results are taken. The results show the significant performance of the proposed model.

  8. Wavelength-Dependent Transient Characteristics Caused by Gain Saturation in Highly Nonlinear Fiber-Based Raman Amplifiers

    Shinobu; Tamaoki; Tetsufumi; Tsuzaki; Motoki; Kakui; Masayuki; Shigematsu

    2003-01-01

    We have investigated the transient characteristics of discrete Raman Amplifiers and found that the response time caused by gain saturation is dependent upon the wavelength, which corresponds to the effective length of the pump light.

  9. Positive Effect of Severe Nakagami-m Fading on the Performance of Multiuser TAS/MRC Systems with High Selection Gain

    Chia-Chun Hung

    2012-01-01

    Full Text Available This paper investigates the positive effect of severe Nakagami-m fading on the performance of multiuser transmit antenna selection/maximal-ratio combining (TAS/MRC systems with high selection gain. Both amount of fading (AF and symbol error rate (SER of M-QAM are derived as closed-form expressions for integer m. For arbitrary m, the AF and the SER are expressible as a single infinite series of Gamma function and Gauss hypergeometric function, respectively. The analytical results lead to the following observations. First, the SER performance can demonstrate the positive effect of severe Nakagami-m fading on multiuser TAS/MRC systems with high selection gain. Second, the AF performance only exhibits the negative impact of severe fading regardless of high selection gain. Last, the benefit of severe fading to the system performance diminishes at high signal-to-noise ratio (SNR.

  10. NEU-P11, a novel melatonin agonist, inhibits weight gain and improves insulin sensitivity in high-fat/high-sucrose-fed rats.

    She, Meihua; Deng, Xiaojian; Guo, Zhenyu; Laudon, Moshe; Hu, Zhuowei; Liao, Duanfang; Hu, Xiaobo; Luo, Yi; Shen, Qingyun; Su, Zehong; Yin, Weidong

    2009-04-01

    Evidences indicate that a complex relationship exists among sleep disorders, obesity and insulin resistance. NEU-P11 is a novel melatonin agonist used in treatment of psychophysiological insomnia, and in animal studies NEU-P11 showed sleep-promoting effect. In this study, we applied NEU-P11 on obese rats to assess its potential melatoninergic effects in vivo. Obese models were established using high-fat/high-sucrose-fed for 5 months. NEU-P11 (10mg/kg)/melatonin (4mg/kg)/vehicle were administered by a daily intraperitoneal injection respectively for 8 weeks. Our results showed that NEU-P11 or melatonin inhibited both body weight gain and deposit of abdominal fat with no influence on food intake. The impaired insulin sensitivity and antioxidative potency were improved and the levels of plasma glucose, total cholesterol (TC), triglycerides (TG) decreased with an increased in HDL-cholesterol (HDL-c) after NEU-P11 or melatonin administration. These data suggest that NEU-P11, like melatonin, decreased body weight gain and improved insulin sensitivity and metabolic profiles in obese rats. We conclude that NEU-P11 has a melatoninergic effect on regulating body weight in obese rats and also improving metabolic profiles and efficiently enhancing insulin sensitivity.

  11. High-Activity Dealloyed Catalysts

    Kongkanand, Anusorn [General Motors LLC, Pontiac, MI (United States)

    2014-09-30

    Reduction of costly Pt usage in proton exchange membrane fuel cell electrodes is one of the major challenges towards development and commercialization of fuel cell vehicles. Although few have met the initial-kinetic activity requirements in a realistic fuel cell device, no catalyst material has ever met the demanding fuel cell durability targets set by DOE. In this project, a team of 4 universities and 2 companies came together to investigate a concept that appeared promising in preliminary non-fuel cell tests then to further develop the catalyst to a mature level ready for vehicle implementation. The team consists of academia with technical leadership in their respective areas, a catalyst supplier, and a fuel cell system integrator.The tightly collaborative project enabled development of a highly active and durable catalyst with performance that significantly exceeds that of previous catalysts and meets the DOE targets for the first time (Figure 1A). The catalyst was then further evaluated in full-active-area stack in a realistic vehicle operating condition (Figure 1B). This is the first public demonstration that one can realize the performance benefit and Pt cost reduction over a conventional pure Pt catalyst in a long-term realistic PEMFC system. Furthermore, systematic analyses of a range of catalysts with different performance after fuel cell testing allowed for correlation between catalyst microstructure and its electrocatalytic activity and durability. This will in turn aid future catalyst development.

  12. Net Gains

    Fielker, David

    2008-01-01

    The Easter conference 2008 had several activities which for the author raised the same questions on cube nets in some work with eight-year-olds some time ago. In this article, the author muses on some problems from the Easter conference regarding nets of shapes. (Contains 1 note.)

  13. Performance, carcass characteristics and gain cost of feedlot cattle fed a high level of concentrate and different feed additives

    Érico Rodrigues

    2013-01-01

    Full Text Available The objective of this study was to evaluate the effects of feeding cattle with isoprotein and isoenergetic diets, with and without the addition of polyclonal antibody preparation (PAP, yeasts (YST or monensin sodium (MON on performance, carcass characteristics and gain cost in feedlot. Ninety-five 20-month old bullocks (323.3±21.8 kg were distributed in 25 pens. The completely randomized experimental design had a 2 × 2 + 1 factorial arrangement and the treatments were replicated 5 times. There was no effect of MON for DMI throughout the feedlot period; however, MON reduced the dry matter intake (DMI in g/kg of BW in the first 28 days when compared with the other treatments. The gain cost decreased with MON addition in relation to the other treatments. Inclusion of YST decreased average daily gain (ADG, final body weight, hot carcass weight, carcass weight, gain to feed ratio and DMI in g/kg body weight, worsening feed conversion and increasing the gain cost in the feeding periods. Inclusion of PAP increased ADG and decreased the gain cost, besides improving feed conversion. For MON and PAP, a difference was found for kidney-pelvic fat and kidney-pelvic fat per 100 kg of hot carcass weight. For MON and YST, there was a difference in ADG, feed conversion, gain cost and carcass yield and kidney-pelvic fat per 100 kg of hot carcass. Treatment YST worsened performance in relation to the non-supplemented treatments. Feeding PAP to animals did not influence performance and carcass characteristics of bullocks in feedlot negatively. Thus, PAP shows potential to substitute MON in cattle feeding using isoprotein and isoenergetic diets.

  14. The study of electromagnetic wave propagation in photonic crystals via planewave based transfer (scattering) matrix method with active gain material applications

    Li, Ming

    In this dissertation, a set of numerical simulation tools are developed under previous work to efficiently and accurately study one-dimensional (1D), two-dimensional (2D), 2D slab and three-dimensional (3D) photonic crystal structures and their defects effects by means of spectrum (transmission, reflection, absorption), band structure (dispersion relation), and electric and/or magnetic fields distribution (mode profiles). Further more, the lasing property and spontaneous emission behaviors are studied when active gain materials are presented in the photonic crystal structures. First, the planewave based transfer (scattering) matrix method (TMM) is described in every detail along with a brief review of photonic crystal history (Chapter 1 and 2). As a frequency domain method, TMM has the following major advantages over other numerical methods: (1) the planewave basis makes Maxwell's Equations a linear algebra problem and there are mature numerical package to solve linear algebra problem such as Lapack and Scalapack (for parallel computation). (2) Transfer (scattering) matrix method make 3D problem into 2D slices and link all slices together via the scattering matrix (S matrix) which reduces computation time and memory usage dramatically and makes 3D real photonic crystal devices design possible; and this also makes the simulated domain no length limitation along the propagation direction (ideal for waveguide simulation). (3) It is a frequency domain method and calculation results are all for steady state, without the influences of finite time span convolution effects and/or transient effects. (4) TMM can treat dispersive material (such as metal at visible light) naturally without introducing any additional computation; and meanwhile TMM can also deal with anisotropic material and magnetic material (such as perfectly matched layer) naturally from its algorithms. (5) Extension of TMM to deal with active gain material can be done through an iteration procedure with gain

  15. Effect of computer mouse gain and visual demand on mouse clicking performance and muscle activation in a young and elderly group of experienced computer users

    Sandfeld, Jesper; Jensen, Bente R.

    2005-01-01

    The present study evaluated the specific effects of motor demand and visual demands on the ability to control motor output in terms of performance and muscle activation. Young and elderly subjects performed multidirectional pointing tasks with the computer mouse. Three levels of mouse gain...... was only to a minor degree influenced by mouse gain (and target sizes) indicating that stability of the forearm/hand is of significance during computer mouse control. The study has implications for ergonomists, pointing device manufacturers and software developers....

  16. Metamaterials with Gain

    Hess, Ortwin

    2012-02-01

    Nanoplasmonic metamaterials are the key to an extreme control of light and allow us to conceive materials with negative or vanishing refractive index. Indeed, metamaterials enable a multitude of exciting and useful applications, such as subwavelength focusing, invisibility cloaking, and ``trapped rainbow'' stopping of light. The realization of these materials has recently advanced from the microwave to the optical regime. However, at optical wavelengths, metamaterials may suffer from high dissipative losses owing to the metallic nature of their constituent nanoplasmonic meta-molecules. It is therefore not surprising that overcoming loss restrictions by gain is currently one of the most important topics in metamaterials' research. At the same time, providing gain on the nanoplasmonic (metamolecular) level opens up exciting new possibilities such as a whole new type of metamaterial nano-laser with a cavity length of about a tenth of the wavelength. The talk gives an overview of the state of the art of gain-enhanced metamaterials. Particular focus will be placed on nano-plasmonic metamaterials (such as double-fishnet metamaterials) with integrated laser dyes as gain medium. The successful compensation of loss by gain is demonstrated on the meta-molecular level. On the basis of a comprehensive, microscopic Maxwell-Bloch Langevin approach of spatio-temporal light amplification and lasing in gain-enhanced nanoplasmonic (negative-index) metamaterials a methodology based on the discrete Poynting's theorem is introduced that allows dynamic tracing of the flow of electromagnetic energy into and out of ``microscopic'' channels (light field, plasmons, gain medium). It is shown that steady-state amplification can be achieved in nanoplasmonic metamaterials. Finally, a complex spatio-temporal interplay of light-field and coherent absorption dynamics is revealed in the lasing dynamics of a nanoplasmonic gain-enhanced double-fishnet metamaterial.

  17. Giant enhancement of optical high-order sideband generation and their control in a dimer of two cavities with gain and loss

    Li, Jiahui; Li, Jiahua; Xiao, Qian; Wu, Ying

    2016-06-01

    Parity-time (PT ) symmetric systems, which rely on the balanced gain-loss condition and render the Hamiltonian non-Hermitian, have provided a new platform to engineer effective light-matter interactions in recent years. Here we explore the high-order sideband features of the output fields obtained from a PT -symmetric optical system consisting of a passive nonlinear cavity coupled to an active linear cavity. By employing a perturbation technique, we derive analytic formulas used to determine the nonlinear transmission coefficient of optical second-order sideband in this structure. Using experimentally achievable parameters, it is clearly shown that the efficiency of the second-order sideband generation can be greatly enhanced in the PT -symmetric dimer, extremely in the vicinity of the transition point from unbroken- to broken-PT regimes. Moreover, we further analyzed the influences of the system parameters, including the photon-tunneling rate between two cavities, Kerr nonlinearity strength, and optical detuning, on the second-order sideband generation. Subsequently we investigate the higher-order sideband output spectrum by numerical simulations, where the sideband amplitude also is largely enhanced in the PT -symmetric arrangement, compared with the passive-passive double-cavity system. Our obtained results provide a new avenue for acquiring optical high-order sidebands and operating light, which may inspire further applications in chip-scale optical communications and optical frequency combs.

  18. Fructans from Agave tequilana with a Lower Degree of Polymerization Prevent Weight Gain, Hyperglycemia and Liver Steatosis in High-Fat Diet-Induced Obese Mice.

    Márquez-Aguirre, A L; Camacho-Ruíz, R M; Gutiérrez-Mercado, Y K; Padilla-Camberos, E; González-Ávila, M; Gálvez-Gastélum, F J; Díaz-Martínez, N E; Ortuño-Sahagún, D

    2016-12-01

    Fructans from agave have received specific attention because of their highly branched fructan content. We have previously reported that the degree of polymerization (dp) influences their biological activity. Therefore, the aim of this study was to investigate the effect of unfractionated and fractionated fructans (higher and lower dps) from Agave tequilana in high-fat diet-induced (HFD) obese mice. Fructans with a lower dp (HFD+ScF) decreased weight gain by 30 %, body fat mass by 51 %, hyperglycemia by 25 % and liver steatosis by 40 %. Interestingly, unfractionated fructans (HFD+F) decreased glucose and triglycerides (TG), whereas fractionated fructans with a higher dp (HFD+LcF) decreased TG but not glucose; in contrast, HFD+ScF decreased glucose but not TG. Our findings suggest that both higher and lower dp agave fructans have complementary effects in metabolic disorders related to obesity. These findings may contribute to the development of improved food supplements with a specific ratio combination of fructans with different dps.

  19. Underrepresented minority high school and college students report STEM-pipeline sustaining gains after participating in the Loma Linda University Summer Health Disparities Research Program.

    Lorena M Salto

    Full Text Available An urgent need exists for graduate and professional schools to establish evidence-based STEM (science, technology, engineering, and math pipeline programs to increase the diversity of the biomedical workforce. An untapped yet promising pool of willing participants are capable high school students that have a strong STEM interest but may lack the skills and the guided mentoring needed to succeed in competitive STEM fields. This study evaluates and compares the impact of the Loma Linda University (LLU Summer Health Disparities Research Program on high school (HS and undergraduate (UG student participants. The primary focus of our summer research experience (SRE is to enhance the research self-efficacy of the participants by actively involving them in a research project and by providing the students with personalized mentoring and targeted career development activities, including education on health disparities. The results of our study show that our SRE influenced terminal degree intent and increased participant willingness to incorporate research into future careers for both the HS and the UG groups. The quantitative data shows that both the HS and the UG participants reported large, statistically significant gains in self-assessed research skills and research self-efficacy. Both participant groups identified the hands-on research and the mentor experience as the most valuable aspects of our SRE and reported increased science skills, increased confidence in science ability and increased motivation and affirmation to pursue a science career. The follow-up data indicates that 67% of the HS participants and 90% of the UG participants graduated from college with a STEM degree; for those who enrolled in graduate education, 61% and 43% enrolled in LLU, respectively. We conclude that structured SREs can be highly effective STEM strengthening interventions for both UG and HS students and may be a way to measurably increase institutional and biomedical

  20. An novel analog programmable power supply for active gain control of the Multi-Pixel Photon Counter (MPPC)

    Li, Zhengwei; Xu, Yupeng; Yan, Bo; Li, Yanguo; Lu, Xuefeng; Li, Xufang; Zhang, Shuo; Chang, Zhi; Li, Jicheng; Zhang, Yifei; Zhao, Jianling

    2016-01-01

    Silicon Photo-Multipliers (SiPM) are regarded as novel photo-detector to replace conventional Photo-Multiplier Tubes (PMTs). However, the breakdown voltage dependence on the ambient temperature results in a gain variation of $\\sim$3$\\% /^{\\circ} \\mathrm C$. This can severely limit the application of this device in experiments with wide range of operating temperature, especially in space telescope. An experimental setup in dark condition was established to investigate the temperature and bias voltage dependence of gain for the Multi-Pixel Photon Counter (MPPC), one type of the SiPM developed by Hamamatsu. The gain and breakdown voltage dependence on operating temperature of an MPPC can be approximated by a linear function, which is similar to the behavior of a zener diode. The measured temperature coefficient of the breakdown voltage is $(59.4 \\pm 0.4$ mV)$/^{\\circ} \\mathrm C$. According to this fact, a programmable power supply based on two zener diodes and an operational amplifier was designed with a positiv...

  1. High energy gain of trapped electrons in a tapered, diffraction-dominated inverse-free-electron laser.

    Musumeci, P; Tochitsky, S Ya; Boucher, S; Clayton, C E; Doyuran, A; England, R J; Joshi, C; Pellegrini, C; Ralph, J E; Rosenzweig, J B; Sung, C; Tolmachev, S; Travish, G; Varfolomeev, A A; Varfolomeev, A A; Yarovoi, T; Yoder, R B

    2005-04-22

    Energy gain of trapped electrons in excess of 20 MeV has been demonstrated in an inverse-free-electron-laser (IFEL) accelerator experiment. A 14.5 MeV electron beam is copropagated with a 400 GW CO2 laser beam in a 50 cm long undulator strongly tapered in period and field amplitude. The Rayleigh range of the laser, approximately 1.8 cm, is much shorter than the undulator length yielding a diffraction-dominated interaction. Experimental results on the dependence of the acceleration on injection energy, laser focus position, and laser power are discussed. Simulations, in good agreement with the experimental data, show that most of the energy gain occurs in the first half of the undulator at a gradient of 70 MeV/m and that the structure in the measured energy spectrum arises because of higher harmonic IFEL interaction in the second half of the undulator.

  2. High Gain Rectangular Microstrip Patch Antenna Employing FR4 Substrate for Wi-MAX, LMDS and MMDS Applications

    Jaspreet Singh

    2016-06-01

    Full Text Available This paper presents an antenna for WiMAX, LMDS and MMDS system applications. FR4 material has been used as substrate having dielectric constant of 4.4. The Patch, Ground and feedline are made of copper. The proposed antenna is rectangular in shape which resonate at 3.42 GHz with a bandwidth of 45MHz (3.40GHz- 3.44GHz and corresponding return loss of -32.39 dB. The performance of the antenna has been analyzed in terms of return loss (dB, gain (dB, directivity (dBi, VSWR and impedance (ohms. The proposed antenna has directivity and gain of 7.2 dBi and 7.28 dB respectively

  3. High-gain complementary metal-oxide-semiconductor inverter based on multi-layer WSe2 field effect transistors without doping

    Kang, Won-Mook; Cho, In-Tak; Roh, Jeongkyun; Lee, Changhee; Lee, Jong-Ho

    2016-10-01

    A high-gain complementary metal-oxide-semiconductor (CMOS) logic inverter was implemented by fabricating p- and n-type field effect transistors (FETs) based on multi-layer WSe2 on the same wafer. Au as a high work-function metal is contacted to WSe2 for the source/drain of the p-type FET. The n-type FET has an Al electrode contacted to WSe2 for the source/drain. Both FETs were designed to have similar on-current densities (>10-7 A μm-1) and high on/off current ratios (>106). The inverter shows excellent switching characteristics including relatively high voltage gains (>25) and high noise margins (>0.9) in the range of supply voltage from 2 V to 8 V. This work has a great significance in the realization of a CMOS logic gate based on WSe2 without an additional doping scheme.

  4. Activation of the prefrontal cortex by unilateral transcranial direct current stimulation leads to an asymmetrical effect on risk preference in frames of gain and loss.

    Ye, Hang; Huang, Daqiang; Wang, Siqi; Zheng, Haoli; Luo, Jun; Chen, Shu

    2016-10-01

    Previous brain imaging and brain stimulation studies have suggested that the dorsolateral prefrontal cortex may be critical in regulating risk-taking behavior, although its specific causal effect on people's risk preference remains controversial. This paper studied the independent modulation of the activity of the right and left dorsolateral prefrontal cortex using various configurations of transcranial direct current stimulation. We designed a risk-measurement table and adopted a within-subject design to compare the same participant's risk preference before and after unilateral stimulation when presented with different frames of gain and loss. The results confirmed a hemispheric asymmetry and indicated that the right dorsolateral prefrontal cortex has an asymmetric effect on risk preference regarding frames of gain and loss. Enhancing the activity of the right dorsolateral prefrontal cortex significantly decreased the participants' degree of risk aversion in the gain frame, whereas it increased the participants' degree of risk aversion in the loss frame. Our findings provide important information regarding the impact of transcranial direct current stimulation on the risk preference of healthy participants. The effects observed in our experiment compared with those of previous studies provide further evidence of the effects of hemispheric and frame-dependent asymmetry. These findings may be helpful in understanding the neural basis of risk preference in humans, especially when faced with decisions involving possible gain or loss relative to the status quo.

  5. High net modal gain (>100 cm(-1)) in 19-stacked InGaAs quantum dot laser diodes at 1000 nm wavelength band.

    Tanoue, Fumihiko; Sugawara, Hiroharu; Akahane, Kouichi; Yamamoto, Naokatsu

    2013-07-01

    An InGaAs quantum dot (QD) laser diode with 19-stacked QDs separated by 20 nm-thick GaAs spacers was fabricated using an ultrahigh-rate molecular beam epitaxial growth technique, and the laser characteristics were evaluated. A 19-stacked simple broad area QD laser diode was lased at the 1000 nm waveband. A net modal gain of 103 cm(-1) was obtained at 2.25 kA/cm(2), and the saturated modal gain was 145.6 cm(-1); these are the highest values obtained to our knowledge. These results indicate that using this technique to highly stack QDs is effective for improving the net modal gain of QD lasers.

  6. Merged beam laser design for reduction of gain-saturation and two-photon absorption in high power single mode semiconductor lasers.

    Lysevych, M; Tan, H H; Karouta, F; Fu, L; Jagadish, C

    2013-04-08

    In this paper we report a method to overcome the limitations of gain-saturation and two-photon absorption faced by developers of high power single mode InP-based lasers and semiconductor optical amplifiers (SOA) including those based on wide-waveguide or slab-coupled optical waveguide laser (SCOWL) technology. The method is based on Y-coupling design of the laser cavity. The reduction in gain-saturation and two-photon absorption in the merged beam laser structures (MBL) are obtained by reducing the intensity of electromagnetic field in the laser cavity. Standard ridge-waveguide lasers and MBLs were fabricated, tested and compared. Despite a slightly higher threshold current, the reduced gain-saturation in MBLs results in higher output power. The MBLs also produced a single spatial mode, as well as a strongly dominating single spectral mode which is the inherent feature of MBL-type cavity.

  7. Salvianolic Acid B Inhibited PPARγ Expression and Attenuated Weight Gain in Mice with High-Fat Diet-Induced Obesity

    Peijian Wang

    2014-07-01

    Full Text Available Background/Aims: Obesity contributes to the development of cardiometabolic disorders such as type 2 diabetes, fatty liver disease and cardiovascular disease. Salvianolic acid B (Sal B is a molecule derived from the root of Salvia miltiorrhiza (Danshen, which is a traditional Chinese medicine that is widely used to treat cardiovascular diseases. However, the role of Sal B in obesity and obesity-related metabolic disorders is unknown. In this study, we aimed to investigate the effects of Sal B on high-fat diet-induced obesity and determine the possible mechanisms involved. Methods: Male C57BL/6J mice fed a high-fat diet for 12 weeks received a supplement of Sal B (100 mg/kg/day by gavage for a further 8 weeks. These mice were compared to control mice fed an un-supplemented high-fat diet. 3T3-L1 preadipocytes were used in vitro studies. Results: Sal B administration significantly decreased body weight, white adipose tissue weight, adipocyte size and lipid (triglyceride and total cholesterol levels in obese mice. Eight weeks of Sal B administration also improved the intraperitoneal glucose tolerance test (IPGTT and intraperitoneal insulin tolerance test (IPITT scores in high-fat diet-induced obese mice. In 3T3-L1 preadipocytes that were cultured in vitro and induced to differentiate, Sal B reduced the accumulation of lipid droplets and lipid content in a dose-dependent manner. Immunoblotting indicated that Sal B decreased peroxisome proliferator-activated receptor gamma (PPARγ and CCAAT/enhancer binding protein α (C/EBPα expression but increased the expression of GATA binding protein 2 and 3 (GATA 2, GATA 3 both in vivo and in vitro. Conclusion: Our data suggest that Sal B may reduce obesity and obesity-related metabolic disorders by suppressing adipogenesis. The effects of Sal B in adipose tissue may be related to its action on PPARγ, C/EBPα, GATA-2 and GATA-3.

  8. Overexpression of Elafin in Ovarian Carcinoma Is Driven by Genomic Gains and Activation of the Nuclear Factor κB Pathway and Is Associated with Poor Overall Survival

    Adam Clauss

    2010-02-01

    Full Text Available Ovarian cancer is a leading cause of cancer mortality in women. The aim of this study was to elucidate whether whey acidic protein (WAP genes on chromosome 20q13.12, a region frequently amplified in this cancer, are expressed in serous carcinoma, the most common form of the disease. Herein, we report that a trio of WAP genes (HE4, SLPI, and Elafin is overexpressed and secreted by serous ovarian carcinomas. To our knowledge, this is the first report linking Elafin to ovarian cancer. Fluorescence in situ hybridization analysis of primary tumors demonstrates genomic gains of the Elafin locus in a majority of cases. In addition, a combination of peptidomimetics, RNA interference, and chromatin immunoprecipitation experiments shows that Elafin expression can be transcriptionally upregulated by inflammatory cytokines through activation of the nuclear factor κB pathway. Importantly, using a clinically annotated tissue microarray composed of late-stage, high-grade serous ovarian carcinomas, we show that Elafin expression correlates with poor overall survival. These results, combined with our observation that Elafin is secreted by ovarian tumors and is minimally expressed in normal tissues, suggest that Elafin may serve as a determinant of poor survival in this disease.

  9. Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria Diet

    Saverio Massimo Lepore

    2015-01-01

    Full Text Available The high consumption of olive tree products in the Mediterranean diet has been associated with a lower incidence of metabolic disorders and cardiovascular diseases. In particular, the protective effects of olive oil have been attributed to the presence of polyphenols such as oleuropein (Ole and its derivatives. We have synthesized a peracetylated derivative of Ole (Ac-Ole which has shown in vitro antioxidant and growth-inhibitory activity higher than the natural molecule. In this study, male C57BL/6JOlaHsd mice were fed with a standard (std, cafeteria (caf diet, and caf diet supplemented with Ole (0.037 mmol/kg/day and Ac-Ole (0.025 mmol/kg/day for 15 weeks. We observed a significant reduction in the caf diet-induced body weight gain and increase of abdominal adipose tissue. Also, Ole and Ac-Ole prevented the development of hepatic steatosis. Finally, Ole and Ac-Ole determined a lower increase of HDL and LDL-cholesterol levels and corrected caf diet-induced elevation of plasma glucose concentrations by improving insulin sensitivity. The observed beneficial properties of Ole and Ac-Ole make these compounds and in particular Ac-Ole promising candidates for a potential pharmaceutic use in metabolic disorders.

  10. Carnosic acid-rich rosemary (Rosmarinus officinalis L.) leaf extract limits weight gain and improves cholesterol levels and glycaemia in mice on a high-fat diet.

    Ibarra, Alvin; Cases, Julien; Roller, Marc; Chiralt-Boix, Amparo; Coussaert, Aurélie; Ripoll, Christophe

    2011-10-01

    Rosemary (Rosmarinus officinalis L.) extracts (RE) are natural antioxidants that are used in food, food supplements and cosmetic applications; exert anti-inflammatory and anti-hyperglycaemic effects; and promote weight loss, which can be exploited to develop new preventive strategies against metabolic disorders. Therefore, the aim of the present study was to evaluate the preventive effects of rosemary leaf extract that was standardised to 20 % carnosic acid (RE) on weight gain, glucose levels and lipid homeostasis in mice that had begun a high-fat diet (HFD) as juveniles. The animals were given a low-fat diet, a HFD or a HFD that was supplemented with 500 mg RE/kg body weight per d (mpk). Physiological and biochemical parameters were monitored for 16 weeks. Body and epididymal fat weight in animals on the HFD that was supplemented with RE increased 69 and 79 % less than those in the HFD group. Treatment with RE was associated with increased faecal fat excretion but not with decreased food intake. The extract also reduced fasting glycaemia and plasma cholesterol levels. In addition, we evaluated the inhibitory effects of RE in vitro on pancreatic lipase and PPAR-γ agonist activity; the in vitro findings correlated with our observations in the animal experiments. Thus, the present results suggest that RE that is rich in carnosic acid can be used as a preventive treatment against metabolic disorders, which merits further examination at physiological doses in randomised controlled trials.

  11. Broadband and high-speed swept external-cavity laser using a quantum-dot superluminescent diode as gain device

    胡发杰; 金鹏; 吴艳华; 王飞飞; 魏恒; 王占国

    2015-01-01

    A wide wavelength tuning range swept external-cavity laser using an InAs/GaAs quantum-dot superluminescent diode as a gain device is demonstrated. The tunable filter consists of a polygon scanner and a grating in Littrow telescope-less configuration. The swept laser generates greater than 54-mW peak output power and up to 33-kHz sweep rate with a sweep range of 150 nm centered at 1155 nm. The effects of injection current and sweep rate on the sweep performance of the swept laser are studied.

  12. Technology developments and first measurements on inverse Low Gain Avalanche Detector (iLGAD) for high energy physics applications

    Carulla, M.; Fernández-García, M.; Fernández-Martínez, P.; Flores, D.; González, J.; Hidalgo, S.; Jaramillo, R.; Merlos, A.; Palomo, F. R.; Pellegrini, G.; Quirion, D.; Vila, I.

    2016-12-01

    The first Inverse Low Gain Avalanche Detector (iLGAD) have been fabricated at IMB-CNM (CSIC). The iLGAD structure includes the multiplication diffusions at the ohmic contact side while the segmentation is implemented at the front side with multiple p+ diffusions. Therefore, iLGAD is p on p position-sensitive detector with a uniform electric field all along the device area that guarantees the same signal amplification wherever a particle passes through the sensitive bulk solving the main draw of the LGAD microstrip detector. However, the detection current is dominated by holes flowing back from the multiplication junction with the subsequent increase of the transient current pulse duration in comparison with conventional LGAD counterparts. Applications of iLGAD range from tracking and timing applications, like determination of primary interaction vertex, to medical imaging. The paper addresses the optimization of the iLGAD structure with the aid of TCAD simulations, focusing on the electric field profiles of iLGAD and LGAD microstrip structures and the corresponding gain. The electrical performance of the first fabricated samples is also provided. For the first time, we have the experimental demonstration of the signal amplification of these novel iLGAD detectors.

  13. Active narrowband filtering, line narrowing and gain using ladder electromagnetically induced transparency in an optically thick atomic vapour

    Keaveney, James; Sarkisyan, David; Papoyan, Aram; Adams, Charles S

    2013-01-01

    Electromagnetically induced transparency (EIT) resonances using the $5\\rm{S}_{1/2}\\rightarrow5\\rm{P}_{3/2}\\rightarrow5\\rm{D}_{5/2}$ ladder-system in optically thick Rb atomic vapour are studied. We observe a strong line narrowing effect and gain at the $5\\rm{S}_{1/2}\\rightarrow5\\rm{P}_{3/2}$ transition wavelength due to an energy-pooling assisted frequency conversion with characteristics similar to four-wave mixing. As a result it is possible to observe tunable and switchable transparency resonances with amplitude close to $100\\%$ and a linewidth of 15 MHz. In addition, the large line narrowing effect allows resolution of $^{85}$Rb $5\\rm{D}_{5/2}$ hyperfine structure even in the presence of strong power broadening.

  14. Technology developments and first measurements on inverse Low Gain Avalanche Detector (iLGAD) for high energy physics applications

    Carulla, M.; Fernández-Martínez, P.; IMB-CNM (CSIC); Flores, D.; IMB-CNM (CSIC); González, J.; Hidalgo, S.; Jaramillo, R.; Merlos, A.; Palomo, F.R.; Pellegrini, G; Quirion, D.; Vila, I.

    2016-01-01

    ABSTRACT: The first Inverse Low Gain Avalanche Detector (iLGAD) have been fabricated at IMB-CNM (CSIC). The iLGAD structure includes the multiplication diffusions at the ohmic contact side while the segmentation is implemented at the front side with multiple P + diffusions. Therefore, iLGAD is P on P position-sensitive detector with a uniform electric field all along the device area that guarantees the same signal amplification wherever a particle passes through the sensitive bulk solving the main draw of the LGAD microstrip detector. However, the detection current is dominated by holes flowing back from the multiplication junction with the subsequent transient current pulse duration increase in comparison with conventional LGAD counterparts. Applications of iLGAD range from tracking and timing applications like determination of primary interaction vertex to medical imaging. The paper addresses the optimization of the iLGAD structure with the aid of TCAD simul...

  15. Eight week exposure to a high sugar high fat diet results in adiposity gain and alterations in metabolic biomarkers in baboons (Papio hamadryas sp.

    Tejero M Elizabeth

    2010-10-01

    Full Text Available Abstract Background Baboons (Papio hamadryas Sp. develop features of the cardiometabolic syndrome and represent a clinically-relevant animal model in which to study the aetiology of the disorder. To further evaluate the baboon as a model for the study of the cardiometabolic syndrome, we developed a high sugar high fat diet and hypothesized that it could be used to induce adiposity gain and affect associated circulating biomarkers. Methods We developed a diet enriched with monosaccharides and saturated fatty acids that was composed of solid and liquid energy sources. We provided a group of baboons (n = 9 ad libitum access to this diet for 8 weeks. Concurrently, a control group (n = 6 was maintained with ad libitum access to a low sugar low fat baseline diet and normal water for 8 weeks. Body composition was determined by dual-energy X-ray absorptiometry and circulating metabolic biomarkers were measured using standard methodology before and after the 8 week study period. Results Neither body composition nor circulating biomarkers changed in the control group. Following the 8 weeks, the intervention group had a significant increase in fat mass (1.71 ± 0.98 vs. 3.23 ± 1.70 kg, p = 0.004, triglyceride (55 ± 13 vs. 109 ± 67 mg/dL, p = 0.006,, and leptin (1.19 ± 1.40 vs. 3.29 ± 2.32 ng/mL, p = 0.001 and a decline in adiponectin concentrations (33530 ± 9744 vs. 23330 ± 7863 ng/mL, p = 0.002. Percentage haemoglobin A1C (4.0 ± 0.3 vs. 6.0 ± 1.4, p = 0.002 also increased in the intervention group. Conclusions Our findings indicate that when exposed to a high sugar high fat diet, young adult male baboons develop increased body fat and triglyceride concentrations, altered adipokine concentrations, and evidence of altered glucose metabolism. Our findings are in keeping with observations in humans and further demonstrate the potential utility of this highly clinically-relevant animal model for studying diet-induced metabolic dysregulation.

  16. Gut microbiota Modulated by Probiotics and Garcinia cambogia Extract Correlate with Weight Gain and Adipocyte Sizes in High Fat-Fed Mice

    Jaeyoung Heo; Minseok Seo; Hwanhee Park; Woon Kyu Lee; Le Luo Guan; Joon Yoon; Kelsey Caetano-Anolles; Hyeonju Ahn; Se-Young Kim; Yoon-Mo Kang; Seoae Cho; Heebal Kim

    2016-01-01

    Results of recent studies on gut microbiota have suggested that obesogenic bacteria exacerbate obesity and metabolic dysfunction in the host when fed a high fat diet (HFD). In order to explore obesity-associated bacterial candidates and their response to diet, the composition of faecal bacterial communities was investigated by analyzing 16S rRNA gene sequences in mice. Dietary intervention with probiotics and Garcinia cambogia extract attenuated weight gain and adipocyte size in HFD-fed mice....

  17. Amorphous silicon germanium carbide photo sensitive bipolar junction transistor with a base-contact and a continuous tunable high current gain

    Bablich, A., E-mail: andreas.bablich@uni-siegen.de [Department of Electrical and Computer Engineering, Institute for Microsystem Technologies, University of Siegen, Hoelderlinstrasse 3, 57076 Siegen (Germany); Merfort, C., E-mail: merfort@imt.e-technik.uni-siegen.de [Department of Electrical and Computer Engineering, Institute for Microsystem Technologies, University of Siegen, Hoelderlinstrasse 3, 57076 Siegen (Germany); Eliasz, J., E-mail: jacek.eliasz@student.uni-siegen.de [Department of Electrical and Computer Engineering, Institute for Microsystem Technologies, University of Siegen, Hoelderlinstrasse 3, 57076 Siegen (Germany); Schäfer-Eberwein, H., E-mail: heiko.schaefer@uni-siegen.de [Department of Electrical and Computer Engineering, Institute of High Frequency and Quantum Electronics, University of Siegen, Hoelderlinstrasse 3, 57076 Siegen (Germany); Haring-Bolivar, P., E-mail: peter.haring@uni-siegen.de [Department of Electrical and Computer Engineering, Institute of High Frequency and Quantum Electronics, University of Siegen, Hoelderlinstrasse 3, 57076 Siegen (Germany); Boehm, M., E-mail: markus.boehm@uni-siegen.de [Department of Electrical and Computer Engineering, Institute for Microsystem Technologies, University of Siegen, Hoelderlinstrasse 3, 57076 Siegen (Germany)

    2014-05-02

    , the device presented in this paper obtains no optical gain with an incident light power of 0.31 μW and 578 nm wavelength. The PS-BJT exhibits promising characteristics with a maximum current density greater than 65 μA μm{sup −1} and a tunable high current gain β. Possible applications exist in fields of control and drive circuits, in display and image devices, in photo interrupters, in photo sensitive matrices or in optoelectronic switches. - Highlights: • Current controllable a-Si:H phototransistor • Controllable high current gain • Current and phototunable transistor.

  18. A C-band 55%PAE high gain two-stage power amplifier based on AlGaN/GaN HEMT

    郑佳欣; 马晓华; 卢阳; 赵博超; 张宏鹤; 张濛; 曹梦逸; 郝跃

    2015-01-01

    A C-band high efficiency and high gain two-stage power amplifier based on AlGaN/GaN high electron mobility transistor (HEMT) is designed and measured in this paper. The input and output impedances for the optimum power-added efficiency (PAE) are determined at the fundamental and 2nd harmonic frequency ( f0 and 2 f0). The harmonic manipulation networks are designed both in the driver stage and the power stage which manipulate the second harmonic to a very low level within the operating frequency band. Then the inter-stage matching network and the output power combining network are calculated to achieve a low insertion loss. So the PAE and the power gain is greatly improved. In an operation frequency range of 5.4 GHz–5.8 GHz in CW mode, the amplifier delivers a maximum output power of 18.62 W, with a PAE of 55.15%and an associated power gain of 28.7 dB, which is an outstanding performance.

  19. A C-band 55% PAE high gain two-stage power amplifier based on AlGaN/GaN HEMT

    Zheng, Jia-Xin; Ma, Xiao-Hua; Lu, Yang; Zhao, Bo-Chao; Zhang, Hong-He; Zhang, Meng; Cao, Meng-Yi; Hao, Yue

    2015-10-01

    A C-band high efficiency and high gain two-stage power amplifier based on AlGaN/GaN high electron mobility transistor (HEMT) is designed and measured in this paper. The input and output impedances for the optimum power-added efficiency (PAE) are determined at the fundamental and 2nd harmonic frequency (f0 and 2f0). The harmonic manipulation networks are designed both in the driver stage and the power stage which manipulate the second harmonic to a very low level within the operating frequency band. Then the inter-stage matching network and the output power combining network are calculated to achieve a low insertion loss. So the PAE and the power gain is greatly improved. In an operation frequency range of 5.4 GHz-5.8 GHz in CW mode, the amplifier delivers a maximum output power of 18.62 W, with a PAE of 55.15% and an associated power gain of 28.7 dB, which is an outstanding performance. Project supported by the National Key Basic Research Program of China (Grant No. 2011CBA00606), Program for New Century Excellent Talents in University, China (Grant No. NCET-12-0915), and the National Natural Science Foundation of China (Grant No. 61334002).

  20. Auto-digital gain balancing: a new detection scheme for high-speed chemical species tomography of minor constituents

    Pal, Sandip; McCann, Hugh

    2011-11-01

    In many dynamic gas-phase reaction processes, there is great interest to measure the distribution of minor constituents, i.e. automotive gasoline engine exhaust by catalytic conversion, where a characteristic challenge is to image the distribution of 10 ppm (average) of carbon monoxide (CO) at 1000 frames per second across a 50 mm diameter exhaust pipe; this particular problem has been pursued as a case study. In this paper, we present a novel electronic scheme that achieves the required measurement of around 10-3 absorption with 10-4 precision at kHz bandwidth. This was not previously achievable with any known technology. We call the new scheme Auto-Digital Gain Balancing. It is amenable to replication for many simultaneous measurement channels, and it permits simultaneous measurement of multiple species, in some circumstances. Experimental demonstrations are presented in the near-infrared. In single scans of a tunable diode laser, measurements of both CO and CO2 have been made with 20 dB signal-to-noise ratio at peak absorption. This work paves the way for chemical species tomography of minor constituents in many dynamic gas-phase systems.

  1. Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice.

    Iffiú-Soltész, Zsuzsa; Wanecq, Estelle; Lomba, Almudena; Portillo, Maria P; Pellati, Federica; Szöko, Eva; Bour, Sandy; Woodley, John; Milagro, Fermin I; Alfredo Martinez, J; Valet, Philippe; Carpéné, Christian

    2010-04-01

    Benzylamine is found in Moringa oleifera, a plant used to treat diabetes in traditional medicine. In mammals, benzylamine is metabolized by semicarbazide-sensitive amine oxidase (SSAO) to benzaldehyde and hydrogen peroxide. This latter product has insulin-mimicking action, and is involved in the effects of benzylamine on human adipocytes: stimulation of glucose transport and inhibition of lipolysis. This study examined whether chronic, oral administration of benzylamine could improve glucose tolerance and the circulating lipid profile without increasing oxidative stress in overweight and pre-diabetic mice. The benzylamine diffusion across the intestine was verified using everted gut sacs. Then, glucose handling and metabolic markers were measured in mice rendered insulin-resistant when fed a high-fat diet (HFD) and receiving or not benzylamine in their drinking water (3600micromol/(kgday)) for 17 weeks. HFD-benzylamine mice showed lower body weight gain, fasting blood glucose, total plasma cholesterol and hyperglycaemic response to glucose load when compared to HFD control. In adipocytes, insulin-induced activation of glucose transport and inhibition of lipolysis remained unchanged. In aorta, benzylamine treatment partially restored the nitrite levels that were reduced by HFD. In liver, lipid peroxidation markers were reduced. Resistin and uric acid, surrogate plasma markers of metabolic syndrome, were decreased. In spite of the putative deleterious nature of the hydrogen peroxide generated during amine oxidation, and in agreement with its in vitro insulin-like actions found on adipocytes, the SSAO-substrate benzylamine could be considered as a potential oral agent to treat metabolic syndrome.

  2. More gain less pain: balance control learning shifts the activation patterns of leg and neck muscles and increases muscular parsimony.

    Iodice, Pierpaolo; Cesinaro, Stefano; Romani, Gian Luca; Pezzulo, Giovanni

    2015-07-01

    Athletes such as skaters or surfers maintain their balance on very unstable platforms. Remarkably, the most skilled athletes seem to execute these feats almost effortlessly. However, the dynamics that lead to the acquisition of a defined and efficient postural strategy are incompletely known. To understand the posture reorganization process due to learning and expertise, we trained twelve participants in a demanding balance/posture maintenance task for 4 months and measured their muscular activity before and after a (predictable) disturbance cued by an auditory signal. The balance training determined significant delays in the latency of participants' muscular activity: from largely anticipatory muscular activity (prior to training) to a mixed anticipatory-compensatory control strategy (after training). After training, the onset of activation was delayed for all muscles, and the sequence of activation systematically reflected the muscle position in the body from top to bottom: neck/upper body muscles were recruited first and in an anticipatory fashion, whereas leg muscles were recruited after the disturbance onset, producing compensatory adjustments. The resulting control strategy includes a mixture of anticipatory and compensatory postural adjustments, with a systematic sequence of muscular activation reflecting the different demands of neck and leg muscles. Our results suggest that subjects learned the precise timing of the disturbance onset and used this information to deploy postural adjustments just-in-time and to transfer at least part of the control of posture from anticipatory to less-demanding feedback-based strategies. In turn, this strategy shift increases the cost-efficiency of muscular activity, which is a key signature of skilled performance.

  3. Image formation using stimulated raman scattering gain

    Bespalov, V. G.; Makarov, E. A.; Stasel'ko, D. I.

    2016-07-01

    Theoretical analysis of the spatial, noise, and energy characteristics of an amplifier has been performed in the mode of spectral and time selection using subnanosecond stimulated Raman Scattering gain of weak echo signals in crystalline active media that are known for high (up to 10-1 cm/MW) gain coefficients. The possibility to reach high gain values has been demonstrated for weak signals from objects at acceptable angular sizes of the field of vision of an amplifier. To provide a signal-to-noise ratio that exceeds unity over the entire field of vision, the number of photons at the input to an amplifier that is required has to exceed the number of its resolution elements. Accurate determination of the possibilities of recording of weak echo signals and quality of images of targets that are obtained using amplifiers under stimulated Raman Scattering requires additional special experiments.

  4. Minimization of the impact of a broad bandwidth high-gain nonlinear preamplifier to the amplified spontaneous emission pedestal of the Vulcan petawatt laser facility.

    Musgrave, I O; Hernandez-Gomez, C; Canny, D; Collier, J; Heathcote, R

    2007-10-01

    To generate petawatt pulses using the Vulcan Nd:glass laser requires a broad bandwidth high-gain preamplifier. The preamplifier used is an optical parametric amplifier that provides a total gain of 10(8) in three amplification stages. We report on a detailed investigation of the effect of the Vulcan optical parametric chirped pulse amplification (OPCPA) preamplifier on contrast caused by the amplified spontaneous emission (ASE) pedestal that extends up to 2 ns before the arrival of the main pulse. The contrast after compression is improved to 4x10(8) of the intensity of the main pulse using near-field apertures between the stages of the OPCPA preamplifier. Further reduction of the level of the ASE pedestal can be achieved at the cost of a reduction in amplified bandwidth by solely phosphate glass amplification after initial preamplification rather than a mixed glass amplification scheme.

  5. No evidence for a role of the peroxisome proliferator-activated receptor gamma (PPARG) and adiponectin (ADIPOQ) genes in antipsychotic-induced weight gain.

    Brandl, Eva J; Tiwari, Arun K; Zai, Clement C; Chowdhury, Nabilah I; Lieberman, Jeffrey A; Meltzer, Herbert Y; Kennedy, James L; Müller, Daniel J

    2014-10-30

    Antipsychotics frequently cause changes in glucose metabolism followed by development of weight gain and/or diabetes. Recent findings from our group indicated an influence of glucose-related genes on this serious side effect. With this study, we aimed to extend previous research and performed a comprehensive study on the peroxisome proliferator-activated receptor gamma (PPARG) and the adiponectin (ADIPOQ) genes. In 216 schizophrenic patients receiving antipsychotics for up to 14 weeks, we investigated single-nucleotide polymorphisms in or near PPARG (N=24) and ADIPOQ (N=18). Statistical analysis was done using ANCOVA in SPSS. Haplotype analysis was performed in UNPHASED 3.1.4 and Haploview 4.2. None of the PPARG or ADIPOQ variants showed significant association with antipsychotic-induced weight gain in our combined sample or in a refined subsample of patients of European ancestry treated with clozapine or olanzapine after correction for multiple testing. Similarly, no haplotype association could withstand multiple test correction. Although we could not find a significant influence of ADIPOQ and PPARG on antipsychotic-induced weight gain, our comprehensive examination of these two genes contributes to understanding the biology of this serious side effect. More research on glucose metabolism genes is warranted to elucidate their role in metabolic changes during antipsychotic treatment.

  6. Contradictions between the Virtual and Physical High School Classroom: A Third-Generation Activity Theory Perspective

    Murphy, Elizabeth; Manzanares, Maria A. Rodriguez

    2008-01-01

    This paper uses a third-generation Activity Theory perspective to gain insight into the contradictions between the activity systems of the physical and virtual high school classroom from the perspective of teachers who had transitioned from one system to the other. Data collection relied on semi-structured interviews conducted with e-teachers as…

  7. Ultra-thin single-layer transparent geometrical phase gradient metasurface and its application to high-gain circularly-polarized lens antenna

    Li, Tang-Jing; Liang, Jian-Gang; Li, Hai-Peng; Liu, Ya-Qiao

    2016-09-01

    A new method to design an ultra-thin high-gain circularly-polarized antenna system with high efficiency is proposed based on the geometrical phase gradient metasurface (GPGM). With an accuracy control of the transmission phase and also the high transmission amplitude, the GPGM is capable of manipulating an electromagnetic wave arbitrarily. A focusing transmission lens working at Ku band is well optimized with the F/D of 0.32. A good focusing effect is demonstrated clearly by theoretical calculation and electromagnetic simulation. For further application, an ultra-thin single-layer transmissive lens antenna based on the proposed focusing metasurface operating at 13 GHz is implemented and launched by an original patch antenna from the perspective of high integration, simple structure, and low cost. Numerical and experimental results coincide well, indicating the advantages of the antenna system, such as a high gain of 17.6 dB, the axis ratio better than 2 dB, a high aperture efficiency of 41%, and also a simple fabrication process based on the convenient print circuit board technology. The good performance of the proposed antenna indicates promising applications in portable communication systems. Project supported by the National Natural Science Foundation of China (Grant No. 61372034).

  8. Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC)

    Zheng, J.; Veerdonk, F.L. van de; Crossland, K.L.; Smeekens, S.P.; Chan, C.M.; Shehri, T. Al; Abinun, M.; Gennery, A.R.; Mann, J.; Lendrem, D.W.; Netea, M.G.; Rowan, A.D.; Lilic, D.

    2015-01-01

    Signal transducer and activator of transcription 3 (STAT3) triggered production of Th-17 cytokines mediates protective immunity against fungi. Mutations affecting the STAT3/interleukin 17 (IL-17) pathway cause selective susceptibility to fungal (Candida) infections, a hallmark of chronic mucocutaneo

  9. Remembering with gains and losses: effects of monetary reward and punishment on successful encoding activation of source memories.

    Shigemune, Yayoi; Tsukiura, Takashi; Kambara, Toshimune; Kawashima, Ryuta

    2014-05-01

    The motivation of getting rewards or avoiding punishments reinforces learning behaviors. Although the neural mechanisms underlying the effect of rewards on episodic memory have been demonstrated, there is little evidence of the effect of punishments on this memory. Our functional magnetic resonance imaging (fMRI) study investigated the effects of monetary rewards and punishments on activation during the encoding of source memories. During encoding, participants memorized words (item) and locations of presented words (source) under 3 conditions (Reward, Punishment, and Control). During retrieval, participants retrieved item and source memories of the words and were rewarded or penalized according to their performance. Source memories encoded with rewards or punishments were remembered better than those without such encoding. fMRI data demonstrated that the ventral tegmental area and substantia nigra and nucleus accumbens activations reflected both the processes of reward and punishment, whereas insular activation increased as a linear function of punishment. Activation in the hippocampus and parahippocampal cortex predicted subsequent retrieval success of source memories. Additionally, correlations between these reward/punishment-related regions and the hippocampus were significant. The successful encoding of source memories could be enhanced by punishments and rewards, and interactions between reward/punishment-related regions and memory-related regions could contribute to memory enhancement by reward and/or punishment.

  10. Designing Gain- and Loss-Framed Messages to Increase Physical Activity among University Students Living in two Different Cultures

    Pelin Ozgur Polat

    2015-10-01

    The primary aim of this project is to gather information through using different methods and investigate the determinants of message persuasiveness in university students from the British and Turkish cultures in order to design effective physical activity messages leading intention, attitude and behaviour change. The results of the finalized studies showed the importance of using both qualitative and quantitative methods in message design process.

  11. Impact of Korean pine nut oil on weight gain and immune responses in high-fat diet-induced obese mice.

    Park, Soyoung; Lim, Yeseo; Shin, Sunhye; Han, Sung Nim

    2013-10-01

    Korean pine nut oil (PNO) has been reported to have favorable effects on lipid metabolism and appetite control. We investigated whether PNO consumption could influence weight gain, and whether the PNO-induced effect would result in an improvement of immune function in high-fat diet (HFD)-induced obese mice. C57BL/6 mice were fed control diets with 10% energy fat from either PNO or soybean oil (SBO), or HFDs with 45% energy fat from 10% PNO or SBO and 35% lard, 20% PNO or SBO and 25% lard, or 30% PNO or SBO and 15% lard for 12 weeks. The proliferative responses of splenocytes upon stimulation with concanavalin A (Con A) or lipopolysaccharide (LPS), Con A-stimulated production of interleukin (IL)-2 and interferon (IFN)-γ, and LPS-stimulated production of IL-6, IL-1β, and prostaglandin E2 (PGE2) by splenocytes were determined. Consumption of HFDs containing PNO resulted in significantly less weight gain (17% less, P PNO consumption resulted in a higher production of IL-1β (P = 0.04). Replacement of SBO with PNO had no effect on the production of IL-2, IFN-γ, IL-6, or PGE2 in mice fed with either the control diets or HFDs. In conclusion, consumption of PNO reduced weight gain in mice fed with HFD, but this effect did not result in the overall improvement in immune responses.

  12. Significant progression of load on the musculoskeletal system with extremely high loads, with rapid weekly weight gains, using the Anatoly Gravitational System, in a 10-week training period

    Burke DT

    2013-10-01

    Full Text Available David T Burke,1 David Tran,1 Di Cui,1 Daniel P Burke,2 Samir Al-Adawi,3 Atsu SS Dorvlo41Emory University Medical School, Atlanta, GA, USA; 2Georgia College and State University, GA, USA; 3Department of Behavioral Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman; 4Department of Mathematics and Statistics, College of Science, Sultan Qaboos University, Muscat, OmanAbstract: In an age of increasing numbers of lifestyle diseases and plasticity of longevity, exercise and weight training have been increasingly recognized as both preventing and mitigating the severity of many illnesses. This study was designed to determine whether significant weight-lifting gains could be realized through the Anatoly Gravitational System. Specifically, this study sought to determine whether this once-weekly weight-training system could result in significant weekly strength gains during a 10-week training period. A total of 50 participants, ranging in age from 17 to 67 years, completed at least 10 weekly 30-minute training sessions. The results suggest participants could, on average, double their weight-lifting capacity within 10 sessions. This preliminary study, which would require further scrutiny, suggests the Anatoly Gravitational System provides a rather unique opportunity to load the musculoskeletal system with extremely high loads, with rapid weekly weight gains, using only short weekly training sessions. More studies are warranted to scrutinize these findings.Keywords: Anatoly Gravitational System, weight training, musculoskeletal system

  13. A gain-coefficient switched Alexandrite laser

    Lee, Chris J; Boller, Klaus-J

    2012-01-01

    We report on a gain-coefficient switched Alexandrite laser. An electro-optic modulator is used to switch between high and low gain states by making use of the polarization dependent gain of Alexandrite. In gain-coefficient switched mode, the laser produces 85 ns pulses with a pulse energy of 240 mJ at a repetition rate of 5 Hz.

  14. A gain-coefficient switched Alexandrite laser

    Lee, Chris J.; Slot, van der Peter J.M.; Boller, Klaus-J.

    2013-01-01

    We report on a gain-coefficient switched Alexandrite laser. An electro-optic modulator is used to switch between high and low gain states by making use of the polarization dependent gain of Alexandrite. In gain-coefficient switched mode, the laser produces 85 ns pulses with a pulse energy of 240 mJ

  15. High-fat-diet-induced weight gain ameliorates bone loss without exacerbating AβPP processing and cognition in female APP/PS1 mice

    Yunhua ePeng

    2014-08-01

    Full Text Available Osteoporosis is negatively correlated with body mass, whereas both osteoporosis and weight loss occur at higher incidence during the progression of Alzheimer’s disease (AD than the age-matched non-dementia individuals. Given that there is no evidence that overweight associated with AD-type cognitive dysfunction, we hypothesized that moderate weight gain might have a protective effect on the bone loss in AD without exacerbating cognitive dysfunction. In the present study, feeding a high-fat-diet (HFD, 45% calorie from fat to female APP/PS1 transgenic mice, an AD animal model, induced weight gain. The bone mineral density, microarchitecture, and biomechanical properties of the femurs were then evaluated. The results showed that the middle-aged female APP/PS1 transgenic mice were susceptible to osteoporosis of the femoral bones and that weight gain significantly enhanced bone mass and mechanical properties. Notably, HFD was not detrimental to brain insulin signaling and AβPP processing, as well as to exploration ability and working, learning and memory performance of the transgenic mice measured by T maze and water maze, compared with the mice fed a normal fat diet (10% calorie from fat. In addition, the circulating levels of leptin but not estradiol were remarkably elevated in HFD-treated mice. These results suggest that a body weight gain induced by the HFD feeding regimen significantly improved bone mass in female APP/PS1 mice with no detriments to exploration ability and spatial memory, most likely via the action of elevated circulating leptin.

  16. Supercontinuum generation in a photonic crystal fiber pumped by a gain-switched high-power fiber laser

    Larsen, Casper; Skovgaard, Peter M. W.; Noordegraaf, Danny;

    2011-01-01

    Supercontinuum (SC) generation in nonlinear photonic crystal fibers (NLF) using continuous-wave (CW) fiber lasers for pumping has been studied before[1,2]. The advantages of CW-SC are high spectral smoothness, high spectral power density, simplicity of the system, and lower noise than the more...... common picosecond-pumped SC. The cost of these features is increased nonlinear fiber lengths due to less efficient nonlinear processes at the lower power levels. Especially, the generation of light in the visible wavelength range has been a challenge. This has previously been tackled by increasing...

  17. Caffeine prevents weight gain and cognitive impairment caused by a high-fat diet while elevating hippocampal BDNF

    Moy, Gregory A.; McNay, Ewan C.

    2012-01-01

    Obesity, high-fat diets, and subsequent type 2 diabetes (T2DM) are associated with cognitive impairment. Moreover, T2DM increases the risk of Alzheimer’s disease (AD) and leads to abnormal elevation of brain beta-amyloid levels, one of the hallmarks of AD. The psychoactive alkaloid caffeine has been shown to have therapeutic potential in AD but the central impact of caffeine has not been well-studied in the context of a high-fat diet. Here we investigated the impact of caffeine administration...

  18. Three months of high-fructose feeding fails to induce excessive weight gain or leptin resistance in mice.

    Erik J Tillman

    Full Text Available High-fructose diets have been implicated in obesity via impairment of leptin signaling in humans and rodents. We investigated whether fructose-induced leptin resistance in mice could be used to study the metabolic consequences of fructose consumption in humans, particularly in children and adolescents. Male C57Bl/6 mice were weaned to a randomly assigned diet: high fructose, high sucrose, high fat, or control (sugar-free, low-fat. Mice were maintained on their diets for at least 14 weeks. While fructose-fed mice regularly consumed more kcal and expended more energy, there was no difference in body weight compared to control by the end of the study. Additionally, after 14 weeks, both fructose-fed and control mice displayed similar leptin sensitivity. Fructose-feeding also did not change circulating glucose, triglycerides, or free fatty acids. Though fructose has been linked to obesity in several animal models, our data fail to support a role for fructose intake through food lasting 3 months in altering of body weight and leptin signaling in mice. The lack of impact of fructose in the food of growing mice on either body weight or leptin sensitivity over this time frame was surprising, and important information for researchers interested in fructose and body weight regulation.

  19. Design of wideband high-gain circularly polarized Vivaldi antenna array%高增益宽带圆极化Vivaldi天线阵的设计

    许唐红; 张弘; 王东; 朱海涛; 兰敏

    2013-01-01

    提出了一种由新型Vivaldi天线单元构成的2×2十字交叉圆极化天线阵.Vivaldi天线单元采用边缘渐变对拓的锯齿结构,提高了天线在4.7~7.0 GHz频带内的增益,其反射系数低于-10 dB的带宽为2.4~11.0 GHz,具有超宽带线极化特性.圆极化天线阵测量结果显示,在4.5~7.0 GHz频带范围内,其轴比均低于3 dB,且整个频带范围内增益达11~13 dBi.%A circularly polarized (CP) crossed antenna array with 2X2 elements based on a novel antipodal Vivaldi antenna is proposed. The Vivaldi antenna with tapering serrated structure at the edges, which is a ultra-wideband (UWB) linearly polarized antenna, has a high gain at 4. 7-7. 0 GHz, and a wide impedance bandwidth of 2. 4-11. 0 GHz when the reflection coefficient is smaller than -10 dB. The measured data of the antenna array show that the axial ratio is lower than 3 dB between 4. 5 GHz and 7. 0 GHz. A high antenna gain from 11 dBi to 13 dBi is also achieved at the whole bandwidth of the array. The proposed antenna element and array both own UWB and high-gain characteristics.

  20. Novel high-gain, improved-bandwidth, finned-ladder V-band Traveling-Wave Tube slow-wave circuit design

    Kory, Carol L.; Wilson, Jeffrey D.

    1994-01-01

    The V-band frequency range of 59-64 GHz is a region of the millimeter-wave spectrum that has been designated for inter-satellite communications. As a first effort to develop a high-efficiency V-band Traveling-Wave Tube (TWT), variations on a ring-plane slow-wave circuit were computationally investigated to develop an alternative to the more conventional ferruled coupled-cavity circuit. The ring-plane circuit was chosen because of its high interaction impedance, large beam aperture, and excellent thermal dissipation properties. Despite these advantages, however, low bandwidth and high voltage requirements have, until now, prevented its acceptance outside the laboratory. In this paper, the three-dimensional electrodynamic simulation code MAFIA (solution of MAxwell's Equation by the Finite-Integration-Algorithm) is used to investigate methods of increasing the bandwidth and lowering the operating voltage of the ring-plane circuit. Calculations of frequency-phase dispersion, beam on-axis interaction impedance, attenuation and small-signal gain per wavelength were performed for various geometric variations and loading distributions of the ring-plane TWT slow-wave circuit. Based on the results of the variations, a circuit termed the finned-ladder TWT slow-wave circuit was designed and is compared here to the scaled prototype ring-plane and a conventional ferruled coupled-cavity TWT circuit over the V-band frequency range. The simulation results indicate that this circuit has a much higher gain, significantly wider bandwidth, and a much lower voltage requirement than the scaled ring-plane prototype circuit, while retaining its excellent thermal dissipation properties. The finned-ladder circuit has a much larger small-signal gain per wavelength than the ferruled coupled-cavity circuit, but with a moderate sacrifice in bandwidth.

  1. Repetition-rate-selectable high-speed optical gating in a VO{sub 2} thin film based on gain modulation of optical amplifier

    Lee, Yong Wook; Kim, Bong Jun; Choi, Sung Youl; Chae, Byung Gyu; Kim, Hyun Tak [Electronics and Telecommunications Research Institute, Daejeon (Korea, Republic of); Lee, Yong Wook [Pukyong National University, Busan (Korea, Republic of); Seo, Gi Wan [University of Science and Technology, Daejeon (Korea, Republic of); Lee, Yong Wan [University of Minnesota, Minneapolis, MN (United States)

    2010-12-15

    In this research, we investigated the dependence of the saturation-induced gain modulation (SIGM) on the modulation frequency of the input signal in an erbium-doped fiber amplifier (EDFA). By finding and incorporating the modulation frequency invariance of the SIGM realizable within some frequency range, we demonstrated a repetition-rate-selectable high-speed optical gating in two-terminal electrical devices based on vanadium-dioxide thin films. In the implemented optical gating system, the repetition rate could be freely chosen as an arbitrary frequency between 0.27 and 10 kHz without any degradation of the gating speed and the signal-to-noise ratio.

  2. Transgenic Rescue of Adipocyte Glucose-dependent Insulinotropic Polypeptide Receptor Expression Restores High Fat Diet-induced Body Weight Gain

    Ugleholdt, Randi; Pedersen, Jens; Bassi, Maria Rosaria

    2011-01-01

    that was similar between the groups. In contrast, glucose-dependent insulinotropic polypeptide-mediated insulin secretion does not seem to be important for regulation of body weight after high fat feeding. The study supports a role of the adipocyte GIPr in nutrient-dependent regulation of body weight and lean mass...... and the direct effects on adipose tissue, we generated transgenic mice with targeted expression of the human GIPr to white adipose tissue or beta-cells, respectively. These mice were then cross-bred with the GIPr knock-out strain. The central findings of the study are that mice with GIPr expression targeted...

  3. Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia.

    Hanna Janke

    Full Text Available About 30% of patients with acute myeloid leukemia (AML harbour mutations of the receptor tyrosine kinase FLT3, mostly internal tandem duplications (ITD and point mutations of the second tyrosine kinase domain (TKD. It was the aim of this study to comprehensively analyze clinical and functional properties of various FLT3 mutants. In 672 normal karyotype AML patients FLT3-ITD, but not FLT3-TKD mutations were associated with a worse relapse free and overall survival in multivariate analysis. In paired diagnosis-relapse samples FLT3-ITD showed higher stability (70% compared to FLT3-TKD (30%. In vitro, FLT3-ITD induced a strong activating phenotype in Ba/F3 cells. In contrast, FLT3-TKD mutations and other point mutations--including two novel mutations--showed a weaker but clear gain-of-function phenotype with gradual increase in proliferation and protection from apoptosis. The pro-proliferative capacity of the investigated FLT3 mutants was associated with cell surface expression and tyrosine 591 phosphorylation of the FLT3 receptor. Western blot experiments revealed STAT5 activation only in FLT3-ITD positive cell lines, in contrast to FLT3-non-ITD mutants, which displayed an enhanced signal of AKT and MAPK activation. Gene expression analysis revealed distinct difference between FLT3-ITD and FLT3-TKD for STAT5 target gene expression as well as deregulation of SOCS2, ENPP2, PRUNE2 and ART3. FLT3-ITD and FLT3 point mutations show a gain-of-function phenotype with distinct signalling properties in vitro. Although poor prognosis in AML is only associated with FLT3-ITD, all activating FLT3 mutations can contribute to leukemogenesis and are thus potential targets for therapeutic interventions.

  4. High Gain Lateral Semi-Insulating GaAs Photoconductive Switch Triggered by 1064 nm Laser Pulses

    施卫; 张显斌; 李琦; 陈二柱; 赵卫

    2002-01-01

    We report on the experimental results of a lateral semi-insulating GaAs photoconductive switch, with a gap of 8mm between two electrodes, triggered by 1064nm laser pulses at a wavelength beyond the GaAs absorption edge. Both the linear and nonlinear modes of the switch were observed when it was triggered by light pulses with an energy of l.9mJ and a pulse width of 60ns, and operated at high voltages of 3 and 5kV. The results show that when the semi-insulating GaAs photoconductive switch operates under an electrical field of 4.37 k V/cm, it will enter into the linear mode first, and then the switch will undergo the nonlinear mode (lock-on) after a delay of about 20 - 100 ns. It is worth noticing that the delay time under high light energy is longer than that in the low optical energy. The non-intrinsic absorption mechanism is discussed. EL2 deep level defects and double-photon absorption in GaAs may play a key part in the absorption process.

  5. Co-regulation analysis of closely linked genes identifies a highly recurrent gain on chromosome 17q25.3 in prostate cancer

    Martínez-A Carlos

    2008-10-01

    Full Text Available Abstract Background Transcriptional profiling of prostate cancer (PC has unveiled new markers of neoplasia and allowed insights into mechanisms underlying this disease. Genomewide analyses have also identified new chromosomal abnormalities associated with PC. The combination of both classes of data for the same sample cohort might provide better criteria for identifying relevant factors involved in neoplasia. Here we describe transcriptional signatures identifying distinct normal and tumoral prostate tissue compartments, and the inference and demonstration of a new, highly recurrent copy number gain on chromosome 17q25.3. Methods We have applied transcriptional profiling to tumoral and non-tumoral prostate samples with relatively homogeneous epithelial representations as well as pure stromal tissue from peripheral prostate and cultured cell lines, followed by quantitative RT-PCR validations and immunohistochemical analysis. In addition, we have performed in silico colocalization analysis of co-regulated genes and validation by fluorescent in situ hybridization (FISH. Results The transcriptomic analysis has allowed us to identify signatures corresponding to non-tumoral luminal and tumoral epithelium, basal epithelial cells, and prostate stromal tissue. In addition, in silico analysis of co-regulated expression of physically linked genes has allowed us to predict the occurrence of a copy number gain at chromosomal region 17q25.3. This computational inference was validated by fluorescent in situ hybridization, which showed gains in this region in over 65% of primary and metastatic tumoral samples. Conclusion Our approach permits to directly link gene copy number variations with transcript co-regulation in association with neoplastic states. Therefore, transcriptomic studies of carefully selected samples can unveil new diagnostic markers and transcriptional signatures highly specific of PC, and lead to the discovery of novel genomic abnormalities

  6. Species' habitat use inferred from environmental variables at multiple scales: How much we gain from high-resolution vegetation data?

    Gastón, Aitor; Ciudad, Carlos; Mateo-Sánchez, María C.; García-Viñas, Juan I.; López-Leiva, César; Fernández-Landa, Alfredo; Marchamalo, Miguel; Cuevas, Jorge; de la Fuente, Begoña; Fortin, Marie-Josée; Saura, Santiago

    2017-03-01

    Spatial resolution of environmental data may influence the results of habitat selection models. As high-resolution data are usually expensive, an assessment of their contribution to the reliability of habitat models is of interest for both researchers and managers. We evaluated how vegetation cover datasets of different spatial resolutions influence the inferences and predictive power of multi-scale habitat selection models for the endangered brown bear populations in the Cantabrian Range (NW Spain). We quantified the relative performance of three types of datasets: (i) coarse resolution data from Corine Land Cover (minimum mapping unit of 25 ha), (ii) medium resolution data from the Forest Map of Spain (minimum mapping unit of 2.25 ha and information on forest canopy cover and tree species present in each polygon), and (iii) high-resolution Lidar data (about 0.5 points/m2) providing a much finer information on forest canopy cover and height. Despite all the models performed well (AUC > 0.80), the predictive ability of multi-scale models significantly increased with spatial resolution, particularly when other predictors of habitat suitability (e.g. human pressure) were not used to indirectly filter out areas with a more degraded vegetation cover. The addition of fine grain information on forest structure (LiDAR) led to a better understanding of landscape use and a more accurate spatial representation of habitat suitability, even for a species with large spatial requirements as the brown bear, which will result in the development of more effective measures to assist endangered species conservation.

  7. Experimental studies of high order soliton compression effect and gain characteristics in femtosecond laser pulses Er3+-doped fiber amplifier

    刘东峰; 陈国夫; 白晋涛; 王贤华

    2000-01-01

    Seed laser pulses with average power of 146 pW and pulse duration of 480 fs were amplified to 14.5 mW. The pulse duration was compressed to 260 fs using 6 m high concentration Er3+ -doped fiber under forward pumping. The amplified signal pulse energy was 0.691 nJ (corresponding to a peak power of 2 657.7 W) and the repetition rate was 20.84 MHz. Spectrum breakup was observed simultaneously. The spectrum of pulses amplified by 3 m Er3+ -doped fiber remains a single peak under different pump power. The amplified pulse duration was compressed abnormally with the increasing pump power using the backward pumping; that is, the amplified pulses were compressed with the increasing pump power under low pump power. When the pump power reached 38 mW, the shortest amplified pulse duration was 309 fs. With further increase in pump power, the amplified pulses began broadening, accompanied by a single peak spectrum under different pump power.

  8. Gut microbiota Modulated by Probiotics and Garcinia cambogia Extract Correlate with Weight Gain and Adipocyte Sizes in High Fat-Fed Mice

    Heo, Jaeyoung; Seo, Minseok; Park, Hwanhee; Lee, Woon Kyu; Guan, Le Luo; Yoon, Joon; Caetano-Anolles, Kelsey; Ahn, Hyeonju; Kim, Se-Young; Kang, Yoon-Mo; Cho, Seoae; Kim, Heebal

    2016-01-01

    Results of recent studies on gut microbiota have suggested that obesogenic bacteria exacerbate obesity and metabolic dysfunction in the host when fed a high fat diet (HFD). In order to explore obesity-associated bacterial candidates and their response to diet, the composition of faecal bacterial communities was investigated by analyzing 16S rRNA gene sequences in mice. Dietary intervention with probiotics and Garcinia cambogia extract attenuated weight gain and adipocyte size in HFD-fed mice. To identify obesity-causative microbiota, two statistical analyses were performed. Forty-eight bacterial species were found to overlap between the two analyses, indicating the commonly identified species as diet-driven and obesity-associated, which would make them strong candidates for host-microbiome interaction on obesity. Finally, correlation based network analysis between diet, microbe, and host revealed that Clostridium aminophilum, a hyper-ammonia-producing bacterium, was highly correlated with obesity phenotypes and other associated bacteria, and shown to be suppressed by the combination of probiotics and Garcinia cambogia extract. Results of the present study suggest that probiotics and Garcinia cambogia extract alleviate weight gain and adiposity, in part via differentially modulating the composition of gut microbiota in HFD fed mice. PMID:27658722

  9. A High-Gain Three-Port Power Converter with Fuel Cell, Battery Sources and Stacked Output for Hybrid Electric Vehicles and DC-Microgrids

    Ching-Ming Lai

    2016-03-01

    Full Text Available This paper proposes a novel high-gain three-port power converter with fuel cell (FC, battery sources and stacked output for a hybrid electric vehicle (HEV connected to a dc-microgrid. In the proposed power converter, the load power can be flexibly distributed between the input sources. Moreover, the charging or discharging of the battery storage device can be controlled effectively using the FC source. The proposed converter has several outputs in series to achieve a high-voltage output, which makes it suitable for interfacing with the HEV and dc-microgrid. On the basis of the charging and discharging states of the battery storage device, two power operation modes are defined. The proposed power converter comprises only one boost inductor integrated with a flyback transformer; the boost and flyback circuit output terminals are stacked to increase the output voltage gain and reduce the voltage stress on the power devices. This paper presents the circuit configuration, operating principle, and steady-state analysis of the proposed converter, and experiments conducted on a laboratory prototype are presented to verify its effectiveness.

  10. Gut microbiota Modulated by Probiotics and Garcinia cambogia Extract Correlate with Weight Gain and Adipocyte Sizes in High Fat-Fed Mice.

    Heo, Jaeyoung; Seo, Minseok; Park, Hwanhee; Lee, Woon Kyu; Guan, Le Luo; Yoon, Joon; Caetano-Anolles, Kelsey; Ahn, Hyeonju; Kim, Se-Young; Kang, Yoon-Mo; Cho, Seoae; Kim, Heebal

    2016-09-23

    Results of recent studies on gut microbiota have suggested that obesogenic bacteria exacerbate obesity and metabolic dysfunction in the host when fed a high fat diet (HFD). In order to explore obesity-associated bacterial candidates and their response to diet, the composition of faecal bacterial communities was investigated by analyzing 16S rRNA gene sequences in mice. Dietary intervention with probiotics and Garcinia cambogia extract attenuated weight gain and adipocyte size in HFD-fed mice. To identify obesity-causative microbiota, two statistical analyses were performed. Forty-eight bacterial species were found to overlap between the two analyses, indicating the commonly identified species as diet-driven and obesity-associated, which would make them strong candidates for host-microbiome interaction on obesity. Finally, correlation based network analysis between diet, microbe, and host revealed that Clostridium aminophilum, a hyper-ammonia-producing bacterium, was highly correlated with obesity phenotypes and other associated bacteria, and shown to be suppressed by the combination of probiotics and Garcinia cambogia extract. Results of the present study suggest that probiotics and Garcinia cambogia extract alleviate weight gain and adiposity, in part via differentially modulating the composition of gut microbiota in HFD fed mice.

  11. Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity.

    Christian C Evans

    Full Text Available Diet-induced obesity (DIO is a significant health concern which has been linked to structural and functional changes in the gut microbiota. Exercise (Ex is effective in preventing obesity, but whether Ex alters the gut microbiota during development with high fat (HF feeding is unknown.Determine the effects of voluntary Ex on the gastrointestinal microbiota in LF-fed mice and in HF-DIO.Male C57BL/6 littermates (5 weeks were distributed equally into 4 groups: low fat (LF sedentary (Sed LF/Sed, LF/Ex, HF/Sed and HF/Ex. Mice were individually housed and LF/Ex and HF/Ex cages were equipped with a wheel and odometer to record Ex. Fecal samples were collected at baseline, 6 weeks and 12 weeks and used for bacterial DNA isolation. DNA was subjected both to quantitative PCR using primers specific to the 16S rRNA encoding genes for Bacteroidetes and Firmicutes and to sequencing for lower taxonomic identification using the Illumina MiSeq platform. Data were analyzed using a one or two-way ANOVA or Pearson correlation.HF diet resulted in significantly greater body weight and adiposity as well as decreased glucose tolerance that were prevented by voluntary Ex (p<0.05. Visualization of Unifrac distance data with principal coordinates analysis indicated clustering by both diet and Ex at week 12. Sequencing demonstrated Ex-induced changes in the percentage of major bacterial phyla at 12 weeks. A correlation between total Ex distance and the ΔCt Bacteroidetes: ΔCt Firmicutes ratio from qPCR demonstrated a significant inverse correlation (r2 = 0.35, p = 0.043.Ex induces a unique shift in the gut microbiota that is different from dietary effects. Microbiota changes may play a role in Ex prevention of HF-DIO.

  12. Exercise Prevents Weight Gain and Alters the Gut Microbiota in a Mouse Model of High Fat Diet-Induced Obesity

    Evans, Christian C.; LePard, Kathy J.; Kwak, Jeff W.; Stancukas, Mary C.; Laskowski, Samantha; Dougherty, Joseph; Moulton, Laura; Glawe, Adam; Wang, Yunwei; Leone, Vanessa; Antonopoulos, Dionysios A.; Smith, Dan; Chang, Eugene B.; Ciancio, Mae J.

    2014-01-01

    Background Diet-induced obesity (DIO) is a significant health concern which has been linked to structural and functional changes in the gut microbiota. Exercise (Ex) is effective in preventing obesity, but whether Ex alters the gut microbiota during development with high fat (HF) feeding is unknown. Objective Determine the effects of voluntary Ex on the gastrointestinal microbiota in LF-fed mice and in HF-DIO. Methods Male C57BL/6 littermates (5 weeks) were distributed equally into 4 groups: low fat (LF) sedentary (Sed) LF/Sed, LF/Ex, HF/Sed and HF/Ex. Mice were individually housed and LF/Ex and HF/Ex cages were equipped with a wheel and odometer to record Ex. Fecal samples were collected at baseline, 6 weeks and 12 weeks and used for bacterial DNA isolation. DNA was subjected both to quantitative PCR using primers specific to the 16S rRNA encoding genes for Bacteroidetes and Firmicutes and to sequencing for lower taxonomic identification using the Illumina MiSeq platform. Data were analyzed using a one or two-way ANOVA or Pearson correlation. Results HF diet resulted in significantly greater body weight and adiposity as well as decreased glucose tolerance that were prevented by voluntary Ex (p<0.05). Visualization of Unifrac distance data with principal coordinates analysis indicated clustering by both diet and Ex at week 12. Sequencing demonstrated Ex-induced changes in the percentage of major bacterial phyla at 12 weeks. A correlation between total Ex distance and the ΔCt Bacteroidetes: ΔCt Firmicutes ratio from qPCR demonstrated a significant inverse correlation (r2 = 0.35, p = 0.043). Conclusion Ex induces a unique shift in the gut microbiota that is different from dietary effects. Microbiota changes may play a role in Ex prevention of HF-DIO. PMID:24670791

  13. Multipolar, time-dynamical model for the loss compensation and lasing of a spherical plasmonic nanoparticle spaser immersed in an active gain medium

    Veltri, Alessandro; Chipouline, Arkadi; Aradian, Ashod

    2016-09-01

    The plasmonic response of a metal nanoparticle in the presence of surrounding gain elements is studied, using a space and time-dependent model, which integrates a quantum formalism to describe the gain and a classical treatment for the metal. Our model fully takes into account the influence of the system geometry (nanosphere) and offers for the first time, the possibility to describe the temporal evolution of the fields and the coupling among the multipolar modes of the particle. We calculate the lasing threshold value for all multipoles of the spaser, and demonstrate that the dipolar one is lowest. The onset of the lasing instability, in the linear regime, is then studied both with and without external field forcing. We also study the behaviour of the system below the lasing threshold, with the external field, demonstrating the existence of an amplification regime where the nanoparticle’s plasmon is strongly enhanced as the threshold is approached. Finally, a qualitative discussion is provided on later, non-linear stages of the dynamics and the approach to the steady-state of the spaser; in particular, it is shown that, for the considered geometry, the spasing is necessarily multi-modal and multipolar modes are always activated.

  14. New insights into nitrate dynamics in a karst groundwater system gained from in situ high-frequency optical sensor measurements

    Opsahl, S. P.; Musgrove, M.; Slattery, R. N.

    2017-03-01

    Understanding nitrate dynamics in groundwater systems as a function of climatic conditions, especially during contrasting patterns of drought and wet cycles, is limited by a lack of temporal and spatial data. Nitrate sensors have the capability for making accurate, high-frequency measurements of nitrate in situ, but have not yet been evaluated for long-term use in groundwater wells. We measured in situ nitrate continuously in two groundwater monitoring wells -one rural and one urban-located in the recharge zone of a productive karst aquifer in central Texas in order to resolve changes that occur over both short-term (hourly to daily) and long-term (monthly to yearly) periods. Nitrate concentrations, measured as nitrate-nitrogen in milligrams per liter (mg/L), during drought conditions showed little or no temporal change as groundwater levels declined. During aquifer recharge, extremely rapid changes in concentration occurred at both wells as documented by hourly data. At both sites, nitrate concentrations were affected by recharging surface water as evidenced by nitrate concentrations in groundwater recharge (0.8-1.3 mg/L) that were similar to previously reported values for regional recharging streams. Groundwater nitrate concentrations responded differently at urban and rural sites during groundwater recharge. Concentrations at the rural well (approximately 1.0 mg/L) increased as a result of higher nitrate concentrations in groundwater recharge relative to ambient nitrate concentrations in groundwater, whereas concentrations at the urban well (approximately 2.7 mg/L) decreased as a result of the dilution of higher ambient nitrate concentrations relative to those in groundwater recharge. Notably, nitrate concentrations decreased to as low as 0.8 mg/L at the urban site during recharge but postrecharge concentrations exceeded 3.0 mg/L. A return to higher nitrate concentrations postrecharge indicates mobilization of a localized source of elevated nitrate within the

  15. High effective silica fume alkali activator

    Vladimír Živica

    2004-04-01

    Growing demands on the engineering properties of cement based materials and the urgency to decrease unsuitable ecologic impact of Portland cement manufacturing represent significant motivation for the development of new cement corresponding to these aspects. One category represents prospective alkali activated cements. A significant factor influencing their properties is alkali activator used. In this paper we present a new high effective alkali activator prepared from silica fume and its effectiveness. According to the results obtained this activator seems to be more effective than currently used activators like natrium hydroxide, natrium carbonate, and water glass.

  16. A flexible and high-performance bidirectional optical amplifier with all optical gain control using ASE noise path through multi-port circulators

    An Vu Tran; Chang-Joon Chae; Rodney S. Tucker

    2003-01-01

    We report a flexible all-optical gain controlled bidirectional optical amplifier. The device achieves constant gain and low noise figure over a large input power range. Moreover, the device removes Rayleigh backscattered light and amplifier noise.

  17. Effects on weight gain and gut microbiota in rats given bacterial supplements and a high-energy-dense diet from fetal life through to 6 months of age.

    Karlsson, Caroline L J; Molin, Göran; Fåk, Frida; Johansson Hagslätt, Marie-Louise; Jakesevic, Maja; Håkansson, Åsa; Jeppsson, Bengt; Weström, Björn; Ahrné, Siv

    2011-09-01

    The aim of the present study was to assess the long-term effects of a high-energy-dense diet, supplemented with Lactobacillus plantarum (Lp) or Escherichia coli (Ec), on weight gain, fattening and the gut microbiota in rats. Since the mother's dietary habits can influence offspring physiology, dietary regimens started with the dams at pregnancy and throughout lactation and continued with the offspring for 6 months. The weight gain of group Lp was lower than that of groups C (control) and Ec (P = 0·086). More retroperitoneal adipose tissue (P = 0·030) and higher plasma leptin (P = 0·035) were observed in group Ec compared with group Lp. The viable count of Enterobacteriaceae was higher in group Ec than in group Lp (P = 0·019), and when all animals were compared, Enterobacteriaceae correlated positively with body weight (r 0·428, P = 0·029). Bacterial diversity was lower in group Ec than in groups C (P ≤ 0·05) and Lp (P ≤ 0·05). Firmicutes, Bacteroidetes and Verrucomicrobia dominated in all groups, but Bacteroidetes were more prevalent in group C than in groups Lp (P = 0·036) and Ec (P = 0·056). The same five bacterial families dominated the microbiota of groups Ec and C, and four of these were also present in group Lp. The other five families dominating in group Lp were not found in any of the other groups. Multivariate data analysis pointed in the same directions as the univariate statistics. The present results suggest that supplementation of L. plantarum or E. coli can have long-term effects on the composition of the intestinal microbiota, as well as on weight gain and fattening.

  18. Whey-reduced weight gain is associated with a temporary growth reduction in young mice fed a high-fat diet

    Tranberg, Britt; Madsen, Andreas N.; Hansen, Axel K.;

    2015-01-01

    Whey protein consumption reportedly alleviates parameters of the metabolic syndrome. Here, we investigated the effects of whey protein isolate (whey) in young mice fed a high-fat diet. We hypothesized that whey as the sole protein source reduced early weight gain associated with retarded growth...... and decreased concentration of insulin-like growth factor-1. Moreover, we hypothesized that these changes were explained by increased nitrogen loss via elevated urea production and/or increased energy expenditure. Male 5-week-old C57BL/6 mice were fed high-fat diets with the protein source being either whey......, casein or a combination of both for 5 weeks. After 1, 3 or 5 weeks, respectively, the mice were subjected to a meal challenge with measurements of blood and urinary urea before and 1 and 3 h after eating a weighed meal of their respective diets. In a subset of mice, energy expenditure was measured...

  19. Challenges for the Adaptive Gain Integrating Pixel Detector (AGIPD) design due to the high intensity photon radiation environment at the European XFEL

    Becker, J; Göttlicher, P; Graafsma, H; Hirsemann, H; Jack, S; Klyuev, A; Marras, S Lange A; Trunk, U; Klanner, R; Schwandt, J; Zhang, J; Dinapoli, R; Greiffenberg, D; Henrich, B; Mozzanica, A; Schmitt, B; Shi, X; Gronewald, M; Krüger, H

    2013-01-01

    The European X-ray Free Electron Laser (XFEL) is a new research facility currently under construction in Hamburg, Germany. With a pulse length of less than 100 fs and an extremely high luminosity of 27000 flashes per second the European XFEL will have a unique time structure that demands the development of new detectors tailored to the requirements imposed by the experiments while complying with the machine specific operation parameters. The Adaptive Gain Integrating Pixel Detector (AGIPD) is one response to the need for large 2D detectors, able to cope with the 4.5 MHz frame rate, as well as with the high dynamic range needed by XFEL experiments ranging from single photons to more than 10$^4$ 12 keV photons per pixel per pulse. In addition it has to withstand doses of up to 1 GGy over three years.

  20. Weight Gain during Pregnancy

    ... report card Careers Archives Pregnancy Before or between pregnancies Nutrition, weight & fitness Prenatal care Is it safe? Labor & ... more. Stony Point, NY 10980 Close X Home > Pregnancy > Nutrition, weight & fitness > Weight gain during pregnancy Weight gain ...

  1. The Study of Electromagnetic Wave Propogation in Photonic Crystals Via Planewave Based Transfer (Scattering) Matrix Method with Active Gain Material Applications

    LI, Ming [Iowa State Univ., Ames, IA (United States)

    2007-01-01

    In this dissertation, a set of numerical simulation tools are developed under previous work to efficiently and accurately study one-dimensional (1D), two-dimensional(2D), 2D slab and three-dimensional (3D) photonic crystal structures and their defects effects by means of spectrum (transmission, reflection, absorption), band structure (dispersion relation), and electric and/or magnetic fields distribution (mode profiles). Furthermore, the lasing property and spontaneous emission behaviors are studied when active gain materials are presented in the photonic crystal structures. Various physical properties such as resonant cavity quality factor, waveguide loss, propagation group velocity of electromagnetic wave and light-current curve (for lasing devices) can be obtained from the developed software package.

  2. Tailoring Directive Gain for High-Contrast, Wide-Viewing-Angle Organic Light-Emitting Diodes Using Speckle Image Holograpy Metasurfaces.

    Zhou, Lei; Ou, Qing-Dong; Shen, Su; Zhou, Yun; Fan, Yuan-Yuan; Zhang, Jun; Tang, Jian-Xin

    2016-08-31

    Holography metasurfaces have been used to control the propagation of light to an unprecedented level, exhibiting the immense potential for light steering in organic light-emitting diodes (OLEDs). Here, a new approach to tailoring directive gain for high contrast, wide-viewing-angle OLEDs is proposed by implementing a spcekle image holography (SIH) metasurface. The experimental and theoretical results provide the direct proofs that the SIH metasurface can play very important roles not only in releasing the trapped energy flow insides the devices but also in tailoring the wavefronts to the preferred patterns due to its "regional orientation" k-vectors patterns. The resulting power efficiency and external quantum efficiency of the OLEDs using a SIH metasurface are 1.97 and 1.95 times that of the reference device with a standard architecture. Furthermore, the wavefronts of emitted light are delicately modulated in a polarization-independent manner, yielding 2.5 times higher contrast ratio compared to the reference device. This unique engineered directive gain property is also well-retained for the viewing angles varing from normal to titled ±60° without spectral distortion. These results enrich the understanding of light wavefronts control in OLEDs and highlight its potential application in display as well as light steering for other optoelectronics.

  3. Four-Week Consumption of Malaysian Honey Reduces Excess Weight Gain and Improves Obesity-Related Parameters in High Fat Diet Induced Obese Rats

    Suhana Samat

    2017-01-01

    Full Text Available Many studies revealed the potential of honey consumption in controlling obesity. However, no study has been conducted using Malaysian honey. In this study, we investigated the efficacy of two local Malaysian honey types: Gelam and Acacia honey in reducing excess weight gain and other parameters related to obesity. The quality of both honey types was determined through physicochemical analysis and contents of phenolic and flavonoid. Male Sprague-Dawley rats were induced to become obese using high fat diet (HFD prior to introduction with/without honey or orlistat for four weeks. Significant reductions in excess weight gain and adiposity index were observed in rats fed with Gelam honey compared to HFD rats. Moreover, levels of plasma glucose, triglycerides, and cholesterol, plasma leptin and resistin, liver enzymes, renal function test, and relative organ weight in Gelam and Acacia honey treated groups were reduced significantly when compared to rats fed with HFD only. Similar results were also displayed in rats treated with orlistat, but with hepatotoxicity effects. In conclusion, consumption of honey can be used to control obesity by regulating lipid metabolism and appears to be more effective than orlistat.

  4. Wideband and high-gain frequency stabilization of a 100-W injection-locked Nd:YAG laser for second-generation gravitational wave detectors

    Ohmae, Noriaki; Moriwaki, Shigenori; Mio, Norikatsu

    2010-07-01

    Second-generation gravitational wave detectors require a highly stable laser with an output power greater than 100 W to attain their target sensitivity. We have developed a frequency stabilization system for a 100-W injection-locked Nd:YAG (yttrium aluminum garnet) laser. By placing an external wideband electro-optic modulator used as a fast-frequency actuator in the optical path of the slave output, we can circumvent a phase delay in the frequency control loop originating from the pole of an injection-locked slave cavity. Thus, we have developed an electro-optic modulator made of a MgO-doped stoichiometric LiNbO3 crystal. Using this modulator, we achieve a frequency control bandwidth of 800 kHz and a control gain of 180 dB at 1 kHz. These values satisfy the requirement for a laser frequency control loop in second-generation gravitational wave detectors.

  5. Laser diode structures with a saturable absorber for high-energy picosecond optical pulse generation by combined gain-and Q-switching

    Ryvkin, B. S.; Avrutin, E. A.; Kostamovaara, J. E. K.; Kostamovaara, J. T.

    2017-02-01

    The performance of gain-switched Fabry-Perot asymmetric-waveguide semiconductor lasers with a large equivalent spot size and an intracavity saturable absorber was investigated experimentally and theoretically. The laser with a short (˜20 μm) absorber emitted high-energy afterpulse-free optical pulses in a broad range of injection current pulse amplitudes; optical pulses with a peak power of about 35 W and a duration of about 80 ps at half maximum were achieved with a current pulse with an amplitude of just 8 A and a duration of 1.5 ns. Good quality pulsations were observed in a broad range of elevated temperatures. The introduction of a substantially longer absorber section leads to strong spectral broadening of the output without a significant improvement to pulse energy and peak power.

  6. Generating Isolated Terawatt-Attosecond X-ray Pulses via a Chirped Laser Enhanced High-Gain Free-electron Laser

    Wang, Zhen; Zhao, Zhentang

    2016-01-01

    A feasible method is proposed to generate isolated attosecond terawatt x-ray radiation pulses in high-gain free-electron lasers. In the proposed scheme, a frequency chirped laser pulse is employed to generate a gradually-varied spacing current enhancement of the electron beam and a series of spatiotemporal shifters are applied between the undulator sections to amplify a chosen ultra-short radiation pulse from self-amplified spontaneous emission. Three-dimensional start-to-end simulations have been carried out and the calculation results demonstrated that 0.15 nm x-ray pulses with peak power over 1TW and duration of several tens of attoseconds could be achieved by using the proposed technique.

  7. Wideband and high-gain frequency stabilization of a 100-W injection-locked Nd:YAG laser for second-generation gravitational wave detectors.

    Ohmae, Noriaki; Moriwaki, Shigenori; Mio, Norikatsu

    2010-07-01

    Second-generation gravitational wave detectors require a highly stable laser with an output power greater than 100 W to attain their target sensitivity. We have developed a frequency stabilization system for a 100-W injection-locked Nd:YAG (yttrium aluminum garnet) laser. By placing an external wideband electro-optic modulator used as a fast-frequency actuator in the optical path of the slave output, we can circumvent a phase delay in the frequency control loop originating from the pole of an injection-locked slave cavity. Thus, we have developed an electro-optic modulator made of a MgO-doped stoichiometric LiNbO(3) crystal. Using this modulator, we achieve a frequency control bandwidth of 800 kHz and a control gain of 180 dB at 1 kHz. These values satisfy the requirement for a laser frequency control loop in second-generation gravitational wave detectors.

  8. Gain-of-function mutations in the Toll-like Receptor pathway: TPL2-mediated ERK1/ERK2 MAPK activation, a path to tumorigenesis in lymphoid neoplasms?

    Simon eRousseau

    2016-05-01

    Full Text Available Lymphoid neoplasms form a family of cancers affecting B-cells, T-cells and NK cells. The Toll-Like Receptor (TLR signalling adapter molecule MYD88 is the most frequently mutated gene in these neoplasms. This signalling adaptor relays signals from TLRs to downstream effector pathways such as the Nuclear Factor kappa B (NFB and Mitogen Activated Protein Kinase (MAPK pathways to regulate innate immune responses (Kawai and Akira, 2010. Gain-of-function mutations such as MYD88[L265P] activate downstream signalling pathways in absence of cognate ligands for TLRs, resulting in increased cellular proliferation and survival. This article reports an analysis of non-synonymous somatic mutations found in the TLR signaling network in lymphoid neoplasms. In accordance with previous reports, mutations map to MYD88 pro-inflammatory signaling and not TRIF-mediated Type I IFN production. Interestingly, the analysis of somatic mutations found downstream of the core TLR-signaling network uncovered a strong association with the ERK1/2 MAPK cascade. In support of this analysis, heterologous expression of MYD88[L265P] in HEK 293 cells led to ERK1/2 MAPK phosphorylation in addition to NFB activation. Moreover, this activation is dependent on the protein kinase Tumour Promoting Locus-2 (TPL-2, activated downstream of the IKK complex. Activation of ERK1/2 would then lead to activation, amongst others, of MYC and hnRNP A1, two proteins previously shown to contribute to tumour formation in lymphoid neoplasms. Taken together, this analysis suggests that TLR-mediated tumorigenesis occurs via the TPL2-mediated ERK1/2 activation. Therefore, the hypothesis proposed is that inhibition of ERK1/2 MAPK activation would prevent tumour growth downstream of MYD88[L265]. It will be interesting to test whether pharmacological inhibitors of this pathway show efficacy in primary tumour cells derived from hematologic malignancies such as Waldenstrom’s Macroglobulinemia, where the

  9. ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function

    Lia Zepa

    2011-01-01

    Full Text Available Activating the amyloid cascade by inhibiting the Aβ-degrading enzyme neprilysin in targeted replacement mice, which express either apoE4 or apoE3, results in the specific accumulation of oligomerized Aβ42 in hippocampal CA1 neurons of the apoE4 mice. We presently investigated the extent to which the apoE4-driven accumulation of Aβ42 and the resulting mitochondrial pathology are due to either gain or loss of function. This revealed that inhibition of neprilysin for one week triggers the accumulation of Aβ42 in hippocampal CA1 neurons of the apoE4 mice but not of either the corresponding apoE3 mice or apoE-deficient mice. At 10 days, Aβ42 also accumulated in the CA1 neurons of the apoE-deficient mice but not in those of the apoE3 mice. Mitochondrial pathology, which in the apoE4 mice is an early pathological consequence following inhibition of neprilyisn, also occurs in the apoE-deficient but not in the apoE3 mice and the magnitude of this effect correlates with the levels of accumulated Aβ42 and oligomerized Aβ42 in these mice. These findings suggest that the rate-limiting step in the pathological effects of apoE4 on CA1 neurons is the accumulation of intracellular oligomerized Aβ42 which is mediated via a gain of function property of apoE4.

  10. Change, Gain and Loss

    Fu Mengzi

    2006-01-01

    @@ Five years have passed since the September 11 terrorist attacks occurred. America's counter-terrorism campaign is still on the way.Besides the momentary monumental significance of the fifth anniversary, five years is still too short in regard to the long-term counter-terrorism campaign. Yet, America's president's tenure is eight years at best; most of Bush's presidency time has passed. Five years ago, the U. S. encountered the most serious terrorist attack; the whole nation formed a consensus that counter-terrorism is its utmost priority. President Bush once enjoyed a support rate as high as 90% for over 16 months. But five years later, the trend changes. People can not help but ask: what are the gains and losses of the Republican Party in dealing with national security affairs?

  11. Enclosure for handling high activity materials

    Jimeno de Osso, F.

    1977-07-01

    One of the most important problems that are met at the laboratories producing and handling radioisotopes is that of designing, building and operating enclosures suitable for the safe handling of active substances. With this purpose in mind, an enclosure has been designed and built for handling moderately high activities under a shielding made of 150 mm thick lead. In this report a description is given of those aspects that may be of interest to people working in this field. (Author)

  12. Achieving high-resolution soft-tissue imaging with cone-beam CT: a two-pronged approach for modulation of x-ray fluence and detector gain

    Graham, S. A.; Siewerdsen, J. H.; Moseley, D. J.; Keller, H.; Shkumat, N. A.; Jaffray, D. A.

    2005-04-01

    Cone-beam computed tomography (CBCT) presents a highly promising and challenging advanced application of flat-panel detectors (FPDs). The great advantage of this adaptable technology is in the potential for sub-mm 3D spatial resolution in combination with soft-tissue detectability. While the former is achieved naturally by CBCT systems incorporating modern FPD designs (e.g., 200 - 400 um pixel pitch), the latter presents a significant challenge due to limitations in FPD dynamic range, large field of view, and elevated levels of x-ray scatter in typical CBCT configurations. We are investigating a two-pronged strategy to maximizing soft-tissue detectability in CBCT: 1) front-end solutions, including novel beam modulation designs (viz., spatially varying compensators) that alleviate detector dynamic range requirements, reduce x-ray scatter, and better distribute imaging dose in a manner suited to soft-tissue visualization throughout the field of view; and 2) back-end solutions, including implementation of an advanced FPD design (Varian PaxScan 4030CB) that features dual-gain and dynamic gain switching that effectively extends detector dynamic range to 18 bits. These strategies are explored quantitatively on CBCT imaging platforms developed in our laboratory, including a dedicated CBCT bench and a mobile isocentric C-arm (Siemens PowerMobil). Pre-clinical evaluation of improved soft-tissue visibility was carried out in phantom and patient imaging with the C-arm device. Incorporation of these strategies begin to reveal the full potential of CBCT for soft-tissue visualization, an essential step in realizing broad utility of this adaptable technology for diagnostic and image-guided procedures.

  13. Activity-based Costing (ABC and Activity-based Management(ABMImplementation – Is This the Solution for Organizations to Gain Profitability?

    Ildikó Réka CARDOS

    2011-06-01

    Full Text Available Adherents of ABC/ABM systems claimed traditional management accounting systems generated misleading costs in a contemporary, tumultuous, often changing business environment and implementing ABC/ABM would remedy this. That is why activity-based costing (ABC and activity-based management (ABM represents the symbol of improved competitiveness and efficiency in every organization.The purpose of this article – after analyzing the existing literature in the field – is to emphasize that new cost systems such as ABC and ABM could be a strong couple that assures competitiveness and efficiency for each company. Another objective is to present that, besides its disadvantages, firms implement the ABC/ABM system because it permits better tracing of costs to objects, superior allocation of overheads to cost objects, financial and non-financial analysis and measures useful to managers and management accountants in the decision-making process.

  14. High activity carbon sorbents for mercury capture

    George G. Stavropoulos; Irene S. Diamantopoulou; George E. Skodras; George P. Sakellaropoulos [Aristotle University of Thessaloniki, Thessaloniki (Greece). Chemical Process Engineering Laboratory

    2006-07-01

    High efficiency activated carbons have been prepared for removing mercury from gas streams. Starting materials used were petroleum coke, lignite, charcoal and olive seed waste, and were chemically activated with KOH. Produced adsorbents were primarily characterized for their porosity by N{sub 2} adsorption at 77K. Their mercury retention capacity was characterized based on the breakthrough curves. Compared with typical commercial carbons, they have exhibited considerably enhanced mercury adsorption capacity. An attempt has been made to correlate mercury entrapment and pore structure. It has been shown that physical surface area is increased during activation in contrast to the mercury adsorption capacity that initially increases and tends to decrease at latter stages. Desorption of active sites may be responsible for this behavior. 10 refs., 3 figs., 1 tab.

  15. Weight gain induced by an isocaloric pair-fed high fat diet: a nutriepigenetic study on FASN and NDUFB6 gene promoters.

    Lomba, Almudena; Martínez, J Alfredo; García-Díaz, Diego F; Paternain, Laura; Marti, Amelia; Campión, Javier; Milagro, Fermín I

    2010-01-01

    Experimental studies have demonstrated that dietary macronutrient distribution plays an important role in insulin regulation, a risk factor associated to obesity, diabetes and other metabolic disorders. To assess whether the macronutrient composition of the diet could be related to obesity onset by affecting the epigenetic regulation of gene expression, we investigated in rats the metabolic effects of two pair-fed isocaloric diets: control (rich in carbohydrates) and high fat diet (rich in fat; HFD). Compared to controls, HFD induced higher weight gain and adiposity and impaired glucose tolerance, which was accompanied by a slight increase in adiponectin levels and liver steatosis. Epididymal adipose tissue expression of the fatty acid synthase (FASN) gene and NADH dehydrogenase (ubiquinone) 1β-subcomplex 6 (NDUFB6) were significantly reduced in HFD group. These variations in mRNA levels were accompanied by changes in the methylation patterns of several CpG islands located in the promoter region of these genes. However, no correlations were found between gene expression and the methylation status. These results suggest that high fat intake produces overweighted rats independently of total energy intake. These diets could also induce some epigenetic changes in the promoters of key genes that could influence gene expression and may be behind metabolic alterations.

  16. Digital automatic gain control

    Uzdy, Z.

    1980-01-01

    Performance analysis, used to evaluated fitness of several circuits to digital automatic gain control (AGC), indicates that digital integrator employing coherent amplitude detector (CAD) is best device suited for application. Circuit reduces gain error to half that of conventional analog AGC while making it possible to automatically modify response of receiver to match incoming signal conditions.

  17. Comparing gains and losses.

    McGraw, A Peter; Larsen, Jeff T; Kahneman, Daniel; Schkade, David

    2010-10-01

    Loss aversion in choice is commonly assumed to arise from the anticipation that losses have a greater effect on feelings than gains, but evidence for this assumption in research on judged feelings is mixed. We argue that loss aversion is present in judged feelings when people compare gains and losses and assess them on a common scale. But many situations in which people judge and express their feelings lack these features. When judging their feelings about an outcome, people naturally consider a context of similar outcomes for comparison (e.g., they consider losses against other losses). This process permits gains and losses to be normed separately and produces psychological scale units that may not be the same in size or meaning for gains and losses. Our experiments show loss aversion in judged feelings for tasks that encourage gain-loss comparisons, but not tasks that discourage them, particularly those using bipolar scales.

  18. Production of high specific activity silicon-32

    Phillips, D.R. [Los Alamos National Lab., NM (United States); Brzezinski, M.A. [Univ. of California, Santa Barbara, CA (United States). Marine Biotechnology Center

    1998-12-31

    This is the final report of a three-year, Laboratory Directed Research and Development Project (LDRD) at Los Alamos National Laboratory (LANL). There were two primary objectives for the work performed under this project. The first was to take advantage of capabilities and facilities at Los Alamos to produce the radionuclide {sup 32}Si in unusually high specific activity. The second was to combine the radioanalytical expertise at Los Alamos with the expertise at the University of California to develop methods for the application of {sup 32}Si in biological oceanographic research related to global climate modeling. The first objective was met by developing targetry for proton spallation production of {sup 32}Si in KCl targets and chemistry for its recovery in very high specific activity. The second objective was met by developing a validated field-useable, radioanalytical technique, based upon gas-flow proportional counting, to measure the dynamics of silicon uptake by naturally occurring diatoms.

  19. Rice koji reduced body weight gain, fat accumulation, and blood glucose level in high-fat diet-induced obese mice

    Yumiko Yoshizaki

    2014-08-01

    Full Text Available Rice koji is considered a readily accessible functional food that may have health-promoting effects. We investigated whether white, yellow, and red koji have the anti-obesity effect in C57BL/6J mice fed a high-fat diet (HFD, which is a model for obesity. Mice were fed HFD containing 10% (w/w of rice koji powder or steamed rice for 4 weeks. Weight gain, epididymal white adipose tissue, and total adipose tissue weight were significantly lower in all rice koji groups than in the HFD-rice group after 4 weeks. Feed efficiency was significantly reduced in the yellow koji group. Blood glucose levels were significantly lower in the white and red koji groups with HOMA-R and leptin levels being reduced in the white koji group. White and red koji increased glucose uptake and GLUT4 protein expression in L6 myotube cells. These results showed that all rice koji have the anti-obesity or anti-diabetes effects although the mechanisms may differ depending on the type of rice koji consumed.

  20. Active vibration isolation of high precision machines

    Collette, C; Artoos, K; Hauviller, C

    2010-01-01

    This paper provides a review of active control strategies used to isolate high precisionmachines (e.g. telescopes, particle colliders, interferometers, lithography machines or atomic force microscopes) from external disturbances. The objective of this review is to provide tools to develop the best strategy for a given application. Firstly, the main strategies are presented and compared, using single degree of freedom models. Secondly, the case of huge structures constituted of a large number of elements, like particle colliders or segmented telescopes, is considered.

  1. The effect of a county's public high school summer remediation program on student gains on end-of-course standard of learning tests in Algebra I, Biology, Chemistry, Geometry and World History and Geography II

    Aiken, Brenda L.

    The Commonwealth of Virginia requires high school students to receive a passing grade in core courses and a passing score on End-of-Course Standards of Learning (EOC SOL) tests to receive verified credits that lead to a Virginia high school diploma. These tests are believed to accurately reflect what students should know and be able to do in order to experience success in their endeavors beyond high school. For some students remediation is required to experience success on EOC SOL tests. This study sought to determine the effect of a County's public high school summer remediation program on student gains on EOC SOL tests in Algebra I, Biology, Chemistry, Geometry, and World History and Geography II. Specifically, the purpose of the study sought to determine the following: (a) If significant gains were made by students who attended the summer remediation program; (b) If significant gains were made by students who did not attend the summer remediation program; (c) If there were differences in gain scores of students who attended and those who did not attend the summer remediation program; and (d) If there were differences in gain scores among students who attended the summer remediation program related to school site, gender, ethnicity, learning ability group, socioeconomic status, and level of English proficiency. The results of the study indicate that students who attended and those who did not attend the summer remediation program made significant gains. However, the gains for students who attended the summer remediation program were significantly greater than the gains made by students who did not attend. The study also found that there were no significant differences in gain scores among students who attended the summer remediation program related to gender, ethnicity, learning ability group, socioeconomic status, and level of English proficiency. There were significant differences in Algebra I gain scores related to school site. Recommendations for

  2. Indoor acoustic gain design

    Concha-Abarca, Justo Andres

    2002-11-01

    The design of sound reinforcement systems includes many variables and usually some of these variables are discussed. There are criteria to optimize the performance of the sound reinforcement systems under indoor conditions. The equivalent acoustic distance, the necessary acoustic gain, and the potential acoustic gain are parameters which must be adjusted with respect to the loudspeaker array, electric power and directionality of loudspeakers, the room acoustics conditions, the distance and distribution of the audience, and the type of the original sources. The design and installation of front of the house and monitoring systems have individual criteria. This article is about this criteria and it proposes general considerations for the indoor acoustic gain design.

  3. End-season daily weight gains as rationale for targeted selective treatment against gastrointestinal nematodes in highly exposed first-grazing season cattle.

    Merlin, Aurélie; Chauvin, Alain; Lehebel, Anne; Brisseau, Nadine; Froger, Sébastien; Bareille, Nathalie; Chartier, Christophe

    2017-03-01

    A two-year study was carried out to assess the feasibility of a targeted selective treatment to control gastrointestinal nematodes (GIN) in 24 groups of first grazing season (FGS) cattle. A two-step procedure aiming at defining exposure risk at group level and at identifying the most infected individuals within groups through measurement of the average daily weight gain (ADWG) at housing was used. The first step was to define retrospectively, by grazing management practices (GMP) indicators, two levels of groups' exposure to GIN determined by anti O. ostertagi antibody ODR level (cut-off 0.7). For the low level of exposure, no relationship between parasitological parameters and heifer growth was seen, whereas for the high level ADWG was negatively correlated with increasing Ostertagia ODR values. The best classification was obtained with an expert system modelling the number of Ostertagia L3 generations on plots. GMP input for the expert system included standard data (turnout/housing data and supplementary feeding amount) combined with paddock rotation planning and monthly temperatures. The threshold of 3 successive generations of L3 or more on plots allowed identifying the groups according to low or high infection exposure level, except two groups that were misidentified as being highly exposed. In the second step, individual ADWG was found to be negatively associated with Ostertagia ODR in heifers from groups classified as highly exposed (≥3 generations of L3). In these groups, sensitivity and specificity of ADWG thresholds were calculated for several individual Ostertagia ODR thresholds. The best compromise between sensitivity (i.e., correctly treating the heifers that need to be treated) and specificity (i.e., not treating animals that should not be treated) was equivalent respectively to 76% and 56% (AUC≈0.7) and was reached using an end-season ADWG threshold of 683g/day to detect animals exhibiting an Ostertagia ODR cut-off at 0.93. Other ADWG thresholds

  4. Weight gain - unintentional

    ... be due to menstruation, heart or kidney failure, preeclampsia, or medicines you take. A rapid weight gain ... al. Position of the American Dietetic Association: weight management. J Am Diet Assoc . 2009;109:330-46. ...

  5. High Energy Activation Data Library (HEAD-2009)

    Korovin, Yury A; Konobeyev, Alexander Yu; Stankovskiy, Alexey Yu; Mashnik, Stepan G

    2010-01-01

    A proton activation data library for 682 nuclides from 1-H to 210-Po in the energy range from 150 MeV up to 1 GeV was developed. To calculate proton activation data, the MCNPX 2.6.0 and CASCADE/INPE codes were chosen. Different intranuclear cascade, preequilibrium, and equilibrium nuclear reaction models and their combinations were used. The optimum calculation models have been chosen on the basis of statistical correlations for calculated and experimental proton data taken from the EXFOR library of experimental nuclear data. All the data are written in ENDF-6 format. The library is called HEPAD-2008 (High-Energy Proton Activation Data). A revision of IEAF-2005 neutron activation data library has been performed: A set of nuclides for which the cross-section data can be (and were) updated using more modern and improved models is specified, and the corresponding calculations have been made in the present work. The new version of the library is called IEAF-2009. The HEPAD-2008 and IEAF-2009 are merged to the fin...

  6. The effect of gain saturation in a gain compensated perfect lens

    Andresen, Marte P Hatlo; Haakestad, Magnus W; Krogstad, Harald E; Skaar, Johannes

    2010-01-01

    The transmission of evanescent waves in a gain-compensated perfect lens is discussed. In particular, the impact of gain saturation is included in the analysis, and a method for calculating the fields of such nonlinear systems is developed. Gain compensation clearly improves the resolution; however, a number of nonideal effects arise as a result of gain saturation. The resolution associated with the lens is strongly dependent on the saturation constant of the active medium.

  7. Tunability of optical gain (SWIR region) in type-II In0.70Ga0.30As/GaAs0.40Sb0.60 nano-heterostructure under high pressure

    Nirmal, H. K.; Yadav, Nisha; Dalela, S.; Rathi, Amit; Siddiqui, M. J.; Alvi, P. A.

    2016-06-01

    The interest in applying an external pressure on a nano-heterostructure is to attempt to extract more information about the electronic structure through distortion of the electronic structure. This paper reports the tunability of the optical gain under the high pressure effect in M-shaped type-II In0.70Ga0.30As/GaAs0.40Sb0.60 symmetric lasing nano-heterostructure designed for SWIR generation. In order to simulate the optical gain, the heterostructure has been modeled with the help of six band k.p method. The 6×6 diagonalized k.p Hamiltonian has been solved to evaluate the valence sub-bands (i.e. light and heavy hole energies); and then optical matrix elements and optical gain within TE (Transverse Electric) mode has been calculated. For the injected carrier density of 5×1012/cm2, the optimized optical gain within TE mode is as high as ~9000/cm at the wavelength of ~1.95 μm, thus providing a very important alternative material system for the generation of SWIR wavelength region. The application of very high pressure (2, 5 and 8 GPa) on the structure along [110] direction shows that the gain as well as lasing wavelength both approach to higher values. Thus, the structure can be tuned externally by the application of high pressure within the SWIR region.

  8. A low-power high-performance configurable auto-gain control loop for a digital hearing aid SoC

    Chengying, Chen; Hainan, Liu; Yong, Hei; Jun, Fan; Xiaoyu, Hu

    2013-10-01

    A low-power, configurable auto-gain control loop for a digital hearing aid system on a chip (SoC) is presented. By adopting a mixed-signal feedback control structure and peak detection and judgment, it can work in automatic gain or variable gain control modes through a digital signal processing unit. A noise-reduction and dynamic range (DR) improvement technique is also used to ensure the DR of the circuit in a low-voltage supply. The circuit is implemented in an SMIC 0.13 μm 1P8M CMOS process. The measurement results show that in a 1 V power supply, 1.6 kHz input frequency and 200 mVp—p, the SFDR is 74.3 dB, the THD is 66.1 dB, and the total power is 89 μW, meeting the application requirements of hearing aid SoCs.

  9. High gain L-band erbium-doped fiber amplifier with two-stage double-pass configuration

    S W Harun; N Tamchek; P Poopalan; H Ahmad

    2003-07-01

    An experiment on gain enhancement in the long wavelength band erbium-doped fiber amplifier (L-band EDFA) is demonstrated using dual forward pumping scheme in double-pass system. Compared to a single-stage single-pass scheme, the small signal gain for 1580 nm signal can be improved by 13.5 dB. However, a noise figure penalty of 2.9 dB was obtained due to the backward C-band ASE from second stage and the already amplified signal from the first pass that extracting energy from the forward C-band ASE. The maximum gain improvement of 13.7 dB was obtained at a signal wavelength of 1588 nm while signal and total pump powers were fixed at -30 dBm and 92 mW, respectively.

  10. Relational Information Gain

    Lippi, Marco; Jaeger, Manfred; Frasconi, Paolo;

    2011-01-01

    We introduce relational information gain, a refinement scoring function measuring the informativeness of newly introduced variables. The gain can be interpreted as a conditional entropy in a well-defined sense and can be efficiently approximately computed. In conjunction with simple greedy general......-to-specific search algorithms such as FOIL, it yields an efficient and competitive algorithm in terms of predictive accuracy and compactness of the learned theory. In conjunction with the decision tree learner TILDE, it offers a beneficial alternative to lookahead, achieving similar performance while significantly...

  11. Should I Gain Weight?

    ... If you're having trouble with your body image, talk about how you feel with someone you like and trust who's been through it — maybe a parent, doctor, counselor, coach, or teacher. continue It's the Growth, Not the Gain No ...

  12. Concrete with Highly Active Rice Husk Ash

    FENG Qing-ge; LIN Qing-yu; YU Qi-jun; ZHAO San-ying; YANG Lu-feng; Shuichi Sugita

    2004-01-01

    The overall aim was to investigate the effect of highly active rice husk ash (RHA) produced by an industrial furnace on some properties of concrete. The strength, pore volume and pore distribution of concrete and the Ca(OH)2 content in concrete were investigated by JIS A 1108 (Method of test for compressive strength of concrete), a mercury instrument porosimeter, and the thermogravimetric analysis, respectively. The results show that,with RHA replacement of cement,the compressive strength of concrete is increased evidently;the average pore radius of concrete is greatly decreased, especially the portion of the pores greater than 20nm in radius is decreased while the amount of smaller pores is increased, and the more the RHA replacement, the less the amount of Ca(OH)2 in concrete. The latter two results are the main reasons for the strength enhancement of concrete.

  13. Progress in the development of active heat sink for high-power laser diodes

    Vetrovec, John; Feeler, Ryan; Bonham, Steve

    2010-02-01

    We report on the development of a novel active heat sink for high-power laser diodes offering unparalleled capacity in high-heat flux handling and temperature control. The heat sink receives diode waste heat at high flux and transfers it at reduced flux to environment, coolant fluid, heat pipe, or structure. Thermal conductance of the heat sink is electronically adjustable, allowing for precise control of diode temperature and the output light wavelength. When pumping solid-state lasers, diode wavelength can be precisely tuned to the absorption features of the laser gain medium. This paper presents the AHS concept, scaling laws, model predictions, and data from initial testing.

  14. High-order rational harmonic mode-locking and pulse-amplitude equalization of SOAFL via reshaped gain-switching FPLD pulse injection.

    Lin, Gong-Ru; Kang, Jung-Jui; Lee, Chao-Kuei

    2010-04-26

    The 40-GHz rational harmonic mode-locking (RHML) and pulse-amplitude equalization of a semiconductor optical amplifier based fiber-ring laser (SOAFL) is demonstrated by the injection of a reshaped 10-GHz gain-switching FPLD pulse. A nonlinearly biased Mach-Zehnder modulator (MZM) is employed to detune the shape of the double-peak pulse before injecting the SOA, such that a pulse-amplitude equalized 4th-order RHML-SOAFL can be achieved by reshaping the SOA gain within one modulation period. An optical injection mode-locking model is constructed to simulate the compensation of uneven amplitudes between adjacent RHML pulse peaks before and after pulse-amplitude equalization. The indirect gain compensation technique greatly suppresses the clock amplitude jitter from 45% to 3.5% when achieving 4th-order RHML, and the amplitude fluctuation of sub-rational harmonic modulating envelope is attenuated by 45 dB. After pulse-amplitude equalization, the pulsewidth of the optical-injection RHML-SOAFL is 8 ps, which still obeys the trend predicted by the inverse square root of repetition rate. The phase noise contributed by the residual ASE noise of the RHML-SOAFL is significantly decreased from -84 to -90 dBc/Hz after initiating the pulse-amplitude equalization, corresponding to the timing jitter reduction from 0.5 to 0.28 ps.

  15. Microchannel plate modal gain variations with temperature

    Slater, David C.; Timothy, J. G.

    1993-01-01

    Measurements of the modal gain of two high-gain curved-channel microchannel plates (MCPs) at various operating temperatures are presented. Both MCPs were fabricated from the Long Life glass with 12-micron diam channels on 15-micron centers. The modal gain was found to decrease with increasing temperature at a rate of -0.1 percent C. This reduction of gain with temperature is attributed primarily to an axial temperature gradient along each MCP channel creating a nonuniform electric field within the channel that lowers the effective output gain. A lowering of the secondary electron yield resulting from increased phonon scattering of secondary electrons released within the walls of the MCP channels was assessed, but was found to have a negligible contribution to the drop in gain with temperature.

  16. Ablation of TRPM5 in Mice Results in Reduced Body Weight Gain and Improved Glucose Tolerance and Protects from Excessive Consumption of Sweet Palatable Food when Fed High Caloric Diets.

    Marie H Larsson

    Full Text Available The calcium activated cation channel transient receptor potential channel type M5 (TRPM5 is part of the downstream machinery of the taste receptors and have been shown to play a central role in taste signalling. In addition it is also found in other types of chemosensory cells in various parts of the body as well as in pancreatic β-cells. The aim of this study was to investigate the effects of TRPM5 gene ablation on body weight, insulin sensitivity and other metabolic parameters in long-term high caloric diet induced obesity. Trpm5-/- mice gained significantly less body weight and fat mass on both palatable carbohydrate and fat rich cafeteria diet and 60% high fat diet (HFD and developed less insulin resistance compared to wild type mice. A main finding was the clearly improved glucose tolerance in Trpm5-/- mice compared to wild type mice on cafeteria diet, which was independent of body weight. In addition, it was shown that Trpm5-/- mice consumed the same amount of calories when fed a HFD only or a HFD in combination with a palatable chocolate ball, which is in contrast to wild type mice that increased their caloric intake when fed the combination, mainly due to excessive consumption of the chocolate ball. Thus the palatable sugar containing diet induced overeating was prevented in Trpm5-/- mice. This indicates that sweet taste induced overeating may be a cause for the increased energy intake and glucose intolerance development seen for wild type mice on a sugar and high fat rich cafeteria diet compared to when on a high fat diet. This study point to an important role for the taste signalling system and TRPM5 in diet induced glucose intolerance.

  17. Ablation of TRPM5 in Mice Results in Reduced Body Weight Gain and Improved Glucose Tolerance and Protects from Excessive Consumption of Sweet Palatable Food when Fed High Caloric Diets.

    Larsson, Marie H; Håkansson, Pernilla; Jansen, Frank P; Magnell, Kerstin; Brodin, Peter

    2015-01-01

    The calcium activated cation channel transient receptor potential channel type M5 (TRPM5) is part of the downstream machinery of the taste receptors and have been shown to play a central role in taste signalling. In addition it is also found in other types of chemosensory cells in various parts of the body as well as in pancreatic β-cells. The aim of this study was to investigate the effects of TRPM5 gene ablation on body weight, insulin sensitivity and other metabolic parameters in long-term high caloric diet induced obesity. Trpm5-/- mice gained significantly less body weight and fat mass on both palatable carbohydrate and fat rich cafeteria diet and 60% high fat diet (HFD) and developed less insulin resistance compared to wild type mice. A main finding was the clearly improved glucose tolerance in Trpm5-/- mice compared to wild type mice on cafeteria diet, which was independent of body weight. In addition, it was shown that Trpm5-/- mice consumed the same amount of calories when fed a HFD only or a HFD in combination with a palatable chocolate ball, which is in contrast to wild type mice that increased their caloric intake when fed the combination, mainly due to excessive consumption of the chocolate ball. Thus the palatable sugar containing diet induced overeating was prevented in Trpm5-/- mice. This indicates that sweet taste induced overeating may be a cause for the increased energy intake and glucose intolerance development seen for wild type mice on a sugar and high fat rich cafeteria diet compared to when on a high fat diet. This study point to an important role for the taste signalling system and TRPM5 in diet induced glucose intolerance.

  18. Learn and gain

    Al-Alami, Suhair Eyad Jamal

    2013-01-01

    Initiating the slogan ""love it, live it"", Learn and Gain includes eight short stories, chosen to illustrate various modes of narration, as well as to provoke reflection and discussion on a range of issues. All texts utilized here illustrate how great writers can, with their insight and gift for words, help us to see the world we live in, in new probing and exciting ways. What characterises the book, the author believes, is the integration of the skills of literary competence, communicative c...

  19. Gaining Relational Competitive Advantages

    Hu, Yimei; Zhang, Si; Li, Jizhen

    2015-01-01

    Establishing strategic technological partnerships (STPs) with foreign partners is an increasingly studied topic within the innovation management literature. Partnering firms can jointly create sources of relational competitive advantage. Chinese firms often lack research and development (R......&D) capabilities but are increasingly becoming preferred technological partners for transnational corporations. We investigate an STP between a Scandinavian and a Chinese firm and try to explore how to gain relational competitive advantage by focusing on its two essential stages: relational rent generation...

  20. Gain Shift Corrections at Chi-Nu

    Brown, Tristan Brooks [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Univ. of Massachusetts, Lowell, MA (United States). Dept. of Physics and Applied Physics; Devlin, Matthew James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-08-30

    Ambient conditions have the potential to cause changes in liquid scintillator detector gain that vary with time and temperature. These gain shifts can lead to poor resolution in both energy as well as pulse shape discrimination. In order to correct for these shifts in the Chi-Nu high energy array, a laser system has been developed for calibration of the pulse height signals.

  1. Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity

    Nikonova, Elena V.; Xiong, Yulan; Tanis, Keith Q.; Dawson, Valina L.; Vogel, Robert L.; Finney, Eva M.; Stone, David J.; Reynolds, Ian J.; Kern, Jonathan T.; Dawson, Ted M.

    2012-01-01

    Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are the most common genetic cause of Parkinson's disease (PD) and cause both autosomal dominant familial and sporadic PD. Currently, the physiological and pathogenic activities of LRRK2 are poorly understood. To decipher the biological functions of LRRK2, including the genes and pathways modulated by LRRK2 kinase activity in vivo, we assayed genome-wide mRNA expression in the brain and peripheral tissues from LRRK2 knockout (KO) and kinase hyperactive G2019S (G2019S) transgenic mice. Subtle but significant differences in mRNA expression were observed relative to wild-type (WT) controls in the cortex, striatum and kidney of KO animals, but only in the striatum in the G2019S model. In contrast, robust, consistent and highly significant differences were identified by the direct comparison of KO and G2019S profiles in the cortex, striatum, kidney and muscle, indicating opposite effects on mRNA expression by the two models relative to WT. Ribosomal and glycolytic biological functions were consistently and significantly up-regulated in LRRK2 G2019S compared with LRRK2 KO tissues. Genes involved in membrane-bound organelles, oxidative phosphorylation, mRNA processing and the endoplasmic reticulum were down-regulated in LRRK2 G2019S mice compared with KO. We confirmed the expression patterns of 35 LRRK2-regulated genes using quantitative reverse transcription polymerase chain reaction. These findings provide the first description of the transcriptional responses to genetically modified LRRK2 activity and provide preclinical target engagement and/or pharmacodynamic biomarker strategies for LRRK2 and may inform future therapeutic strategies for LRRK2-associated PD. PMID:21972245

  2. A design of high-gain end-fire antenna based on split-ring resonator structures%一种基于开口谐振环的高增益端射天线设计∗

    刘红喜; 高军; 曹祥玉; 刘艳芳; 张迪; 李思佳

    2015-01-01

    Vivaldi antennas have wide applications in practice due to the ultra-wide band properties;however, their gain and directivity are relatively low. In this paper, a new method is presented to improve the gain and directivity of Vivaldi antennas in a broad band using split-ring resonator (SRR). Based on the peculiar electromagnetic properties of SRR, a novel high-gain SRR-Vivaldi end-fire antenna in C and X bands is designed and fabricated. The size of the antenna is only 0.33λ× 0.33λ× 0.013λ, a significant miniaturization. Equivalent analysis method has been adopted to study the resonance characteristic of an SRR structure. By adding the SRR structures the singular metamaterials in the front of the Vivaldi antenna have an exponential taper slot, and the SRR structures can play a role as a director which has the ability to enhance the antenna’s directivity so that the surface currents will focus on the end-fire direction. The SRR structures have been analyzed, designed, and fabricated, which can be embedded into the original Vivaldi antenna smoothly and compactly. As a result, the gain of the SRR-Vivaldi antenna are enhanced effectively, while the size and bandwidth of the original antenna can be kept, with the reflection coeffcient less than−10 dB from 4 to 13.6 GHz after using SRR. The novel Vivaldi antenna based on the SRR has good features of high gain, high directivity, low return loss and low cross-polarization. Compared to the original Vivaldi antenna, the simulation and measured results demonstrate that the gain of the novel SRR-Vivaldi antenna in C band has been increased by an average value of 75.44% and the half-power beam width has been decreased by 20 degrees in xoy and xoz planes. Meanwhile, the gain has been increased by an average value of 24.46% in X band and the half-power beam width has been decreased by 25 degrees in xoz plane. Testing result of the fabricated antenna demonstrates the reliability of the design. A good agreement between

  3. High-Throughput Analysis of Enzyme Activities

    Lu, Guoxin [Iowa State Univ., Ames, IA (United States)

    2007-01-01

    High-throughput screening (HTS) techniques have been applied to many research fields nowadays. Robot microarray printing technique and automation microtiter handling technique allows HTS performing in both heterogeneous and homogeneous formats, with minimal sample required for each assay element. In this dissertation, new HTS techniques for enzyme activity analysis were developed. First, patterns of immobilized enzyme on nylon screen were detected by multiplexed capillary system. The imaging resolution is limited by the outer diameter of the capillaries. In order to get finer images, capillaries with smaller outer diameters can be used to form the imaging probe. Application of capillary electrophoresis allows separation of the product from the substrate in the reaction mixture, so that the product doesn't have to have different optical properties with the substrate. UV absorption detection allows almost universal detection for organic molecules. Thus, no modifications of either the substrate or the product molecules are necessary. This technique has the potential to be used in screening of local distribution variations of specific bio-molecules in a tissue or in screening of multiple immobilized catalysts. Another high-throughput screening technique is developed by directly monitoring the light intensity of the immobilized-catalyst surface using a scientific charge-coupled device (CCD). Briefly, the surface of enzyme microarray is focused onto a scientific CCD using an objective lens. By carefully choosing the detection wavelength, generation of product on an enzyme spot can be seen by the CCD. Analyzing the light intensity change over time on an enzyme spot can give information of reaction rate. The same microarray can be used for many times. Thus, high-throughput kinetic studies of hundreds of catalytic reactions are made possible. At last, we studied the fluorescence emission spectra of ADP and obtained the detection limits for ADP under three different

  4. Active video games as a tool to prevent excessive weight gain in adolescents : rationale, design and methods of a randomized controlled trial

    Simons, Monique; Chinapaw, Mai J M; van de Bovenkamp, Maaike; de Boer, Michiel R; Seidell, Jacob C; Brug, Johannes; de Vet, Emely

    2014-01-01

    BACKGROUND: Excessive body weight, low physical activity and excessive sedentary time in youth are major public health concerns. A new generation of video games, the ones that require physical activity to play the games--i.e. active games--may be a promising alternative to traditional non-active gam

  5. Obesity-prone high-fat-fed rats reduce caloric intake and adiposity and gain more fat-free mass when allowed to self-select protein from carbohydrate:fat intake.

    Azzout-Marniche, Dalila; Chalvon-Demersay, Tristan; Pimentel, Grégory; Chaumontet, Catherine; Nadkarni, Nachiket A; Piedcoq, Julien; Fromentin, Gilles; Tomé, Daniel; Gaudichon, Claire; Even, Patrick C

    2016-06-01

    We tested the hypothesis that, for rats fed a high-fat diet (HFD), a prioritization of maintaining protein intake may increase energy consumption and hence result in obesity, particularly for individuals prone to obesity ("fat sensitive," FS, vs. "fat resistant," FR). Male Wistar rats (n = 80) first received 3 wk of HFD (protein 15%, fat 42%, carbohydrate 42%), under which they were characterized as being FS (n = 18) or FR (n = 20) based on body weight gain. They then continued on the same HFD but in which protein (100%) was available separately from the carbohydrate:fat (50:50%) mixture. Under this second regimen, all rats maintained their previous protein intake, whereas intake of fat and carbohydrate was reduced by 50%. This increased protein intake to 26% and decreased fat intake to 37%. Adiposity gain was prevented in both FR and FS rats, and gain in fat-free mass was increased only in FS rats. At the end of the study, the rats were killed 2 h after ingestion of a protein meal, and their tissues and organs were collected for analysis of body composition and measurement of mRNA levels in the liver, adipose tissue, arcuate nucleus, and nucleus accumbens. FS rats had a higher expression of genes encoding enzymes involved in lipogenesis in the liver and white adipose tissue. These results show that FS rats strongly reduced food intake and adiposity gain through macronutrient selection, despite maintenance of a relatively high-fat intake and overexpression of genes favoring lipogenesis.

  6. ASTER Urgent Response to the 2006 Eruption of Augustine Volcano, Alaska: Science and Decision Support Gained From Frequent High-resolution, Satellite Thermal Infrared Imaging of Volcanic Events

    Wessels, R. L.; Ramsey, M. S.; Schneider, D. S.; Coombs, M.; Dehn, J.; Realmuto, V. J.

    2006-12-01

    Augustine Volcano, Alaska explosively erupted on January 11, 2006 after nearly eight months of increasing seismicity, deformation, gas emission, and small phreatic explosions. The volcano produced a total of 13 explosive eruptions during the last three weeks of January 2006. A new summit lava dome and two short, blocky lava flows grew during February and March 2006. A series of 7 daytime and 15 nighttime Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) scenes were acquired in response to this new activity. This response was facilitated by a new ASTER Urgent Request Protocol system. The ASTER data provided several significant observations as a part of a much larger suite of real-time or near-real-time data from other satellite (AVHRR, MODIS), airborne (FLIR, visual, gas), and ground-based (seismometers, radiometers) sensors used at the Alaska Volcano Observatory (AVO). ASTER is well-suited to volcanic observations because of its 15-m to 90-m spatial resolution, its ability to be scheduled and point off-nadir, and its ability to collect visible-near infrared (VNIR) to thermal infrared (TIR) data during both the day and night. Aided by the volcano's high latitude (59.4°N) ASTER was able to provide frequent repeat imaging as short as one day between scenes with an average 6-day repeat during the height of activity. These data provided a time series of high-resolution VNIR, shortwave infrared (SWIR - detects temperatures from about 200°C to > 600°C averaged over a 30-m pixel), and TIR (detects temperatures up to about 100°C averaged over a 90-m pixel) data of the volcano and its eruptive products. Frequent satellite imaging of volcanoes is necessary to record rapid changes in activity and to avoid recurring cloud cover. Of the 22 ASTER scenes acquired between October 30, 2005 and May 30, 2006, the volcano was clear to partly cloudy in 13 scenes. The most useful pre-eruption ASTER Urgent Request image was acquired on December 20. These data

  7. Cash and in-kind transfers lead to excess weight gain in a population of women with a high prevalence of overweight in rural Mexico.

    Leroy, Jef L; Gadsden, Paola; González de Cossío, Teresa; Gertler, Paul

    2013-03-01

    There is a growing concern that food or cash transfer programs may contribute to overweight and obesity in adults. We studied the impact of Mexico's Programa de Apoyo Alimentario (PAL), which provided very poor rural households with cash or in-kind transfers, on women's body weight. A random sample of 208 rural communities in southern Mexico was randomly assigned to 1 of 4 groups: food basket with or without health and nutrition education, cash with education, or control. The impact on women's weight was estimated in a cohort of 3010 women using a difference-in-difference model. We compared the impact between the food basket and cash groups and evaluated whether the impact was modified by women's BMI status at baseline. With respect to the control group, the program increased women's weight in the food basket (550 ± 210 g; P = 0.004) and the cash group (420 ± 230 g; P = 0.032); this was equivalent to 70 and 53% increases in weight gain, respectively, over that observed in the control group in a 23-mo time period. The greatest impact was found in already obese women: 980 ± 290 g in the food basket group (P = 0.001) and 670 ± 320 g in the cash group (P = 0.019). Impact was marginally significant in women with a preprogram BMI between 25 and 30 kg/m2: 490 ± 310 g (P = 0.055) and 540 ± 360 g (P = 0.067), respectively. No program impact was found in women with a BMI <25 kg/m2. Providing households with a considerable amount of unrestricted resources led to excess weight gain in an already overweight population. Research is needed to develop cost-effective behavior change communication strategies to complement cash and in-kind transfer programs such as PAL and to help beneficiaries choose healthy diets that improve the nutritional status of all family members.

  8. Theoretical study of the temp erature distribution in high p ower gain fib er of gradient doping%高功率梯度掺杂增益光纤温度特性理论研究∗

    周子超; 王小林; 陶汝茂; 张汉伟; 粟荣涛; 周朴; 许晓军

    2016-01-01

    Thermal effect in the gain fiber is one of the main factors which restrict the power improvement of high power fiber amplifiers. Previous studies have shown that the temperature distribution is closely related to the doping concentration along the gain fiber. In order to reduce the maximum temperature of the gain fiber, we propose to use doping concentra-tion varying along the gain fiber as a method to disperse the thermal effect of the fiber laser and improve the laser output power. Based on the rate equation model and thermal conduction model, the thermal distributions and output powers of several different gradient doping gain fibers are simulated in the cases where the output powers are approximately the same. Our study shows that compared with the conventional constant doping gain fiber, linear doping of the rare earth ion along the gain fiber can reduce the maximum temperature of the gain fiber as well as the temperature of the fusion point greatly, thus improving the stabilities of the fusion point and the fiber laser amplifier. In the case of cosinoidal doping, the gain fiber can not only reduce the temperature of the fusion point but also make the temperature have a periodic distribution along the gain fiber, which can suppress the stimulated Brillouin scattering effect effectively. The exponential doping of the gain fiber can also reduce the maximum temperature and the temperature of the fusion point, which is beneficial to the further scaling of the fiber laser output power. At the same time, it can make the gain of the signal light have a uniform distribution along the gain fiber, which suppresses the mode instability effect and improves the output beam quality of the fiber laser. These conclusions also hold true when the pump power changes. Therefore, the gradient doping of the gain fiber proposed in this paper can optimize the temperature distribution along the fiber and improve the stability of the fusion point. Besides, it can improve the beam

  9. Gain optimization method of a DQW superluminescent diode with broad multi-state emission

    Dimas, Clara E.

    2010-01-01

    Optimizing gain through systematic methods of varying current injection schemes analytically is significant to maximize experimentally device yield and evaluation. Various techniques are used to calculate the amplified spontaneous emission (ASE) gain for light emitting devices consisting of single-section and multiple-sections of even length. Recently double quantum well (DQW) superluminescent diodes (SLD) have shown a broad multi-state emission due to mutlielectrodes of non-equal lengths and at high non-equal current densities. In this study, we adopt an improved method utilizing an ASE intensity ratio to calibrate a gain curve based on the sum of the measured ASE spectra to efficiently estimate the gain. Although the laser gain for GaAs/AlGaAs material is well studied, the ASE gain of SLD devices has not been systematically studied particular to further explain the multiple-state emission observed in fabricated devices. In addition a unique gain estimate was achieved where the excited state gain clamps prior to the ground state due to approaching saturation levels. In our results, high current densities in long sectioned active regions achieved sufficient un-truncated gain that show evidence of excited state emission has been observed.

  10. Gain control mechanisms in spinal motoneurons

    Michael David Johnson

    2014-07-01

    Full Text Available Motoneurons provide the only conduit for motor commands to reach muscles. For many years, motoneurons were in fact considered to be little more than passive wires. Systematic studies in the past 25 years however have clearly demonstrated that the intrinsic electrical properties of motoneurons are under strong neuromodulatory control via multiple sources. The discovery of potent neuromodulation from the brainstem and its ability to change the gain of motoneurons shows that the passive view of the motor output stage is no longer tenable. A mechanism for gain control at the motor output stage makes good functional sense considering our capability of generating an enormous range of forces, from very delicate (e.g. putting in a contact lens to highly forceful (emergency reactions. Just as sensory systems need gain control to deal with a wide dynamic range of inputs, so to might motor output need gain control to deal with the wide dynamic range of the normal movement repertoire. Two problems emerge from the potential use of the brainstem monoaminergic projection to motoneurons for gain control. First, the projection is highly diffuse anatomically, so that independent control of the gains of different motor pools is not feasible. In fact, the system is so diffuse that gain for all the motor pools in a limb likely increases in concert. Second, if there is a system that increases gain, probably a system to reduce gain is also needed. In this review, we summarize recent studies that show local inhibitory circuits within the spinal cord, especially reciprocal and recurrent inhibition, have the potential to solve both of these problems as well as constitute another source of gain modulation.

  11. A Switching Method for a Model Reference Robust Control with Unknown High Frequency Gain Sign%高频增益符号未知的模型参考鲁棒控制

    袁丽娜; 林岩

    2006-01-01

    The problem of controlling a single-input-single-output plant without prior knowledge of high frequency gain sign is addressed by using the model reference robust control approach. A switching method is proposed based on a monitoring function so that after a finite number of switchings the tracking error converges to zero exponentially. Furthermore, it is shown that if some initial states of the closed-loop system are zero, only one switching is needed.

  12. Gain measurements on the sequence bands in a TEA-CO/sub 2/ amplifier

    Lavigne, P.; Lachambre, J.; Otis, G.

    1978-07-01

    Small-signal gains as high as 1.5% cm/sup -/1 have been measured in a TEA-CO/sub 2/ amplifier on the 00/sup 0/2- (10/sup 0/1, 02/sup 0/1)/sub I,II/ sequence bands. The ratio of the gain coefficient of the sequence bands over the gain coefficient of the regular bands has been observed to be independent of either the CO/sub 2/ or He proportion in the gas mixture. It has also been found to increase with the electrical energy dumped into the active medium and to reach a value of 1/3 at an excitation density of 140 J/l. Gain on the sequence bands has been found to be responsible for the anomalously high gain coefficient that is measured at low J values of the R branch of the regular 9.4-..mu..m transition in TEA amplifiers.

  13. Activities for gaining insight into IASCC and continuous evaluation of in-service inspection data; Arbeiten zu IASCC und Kontinuierliche Auswertung und Bewertung der Ergebnisse der wiederkehrenden Pruefungen

    Huettner, F.; Weber, G.; Wuensch, G.

    1999-06-01

    The report is a documentation of the important results of various international studies conducted to gain insight into the occurrence, mechanisms, and characteristic features of irradiation-assisted stress corrosion cracking, IASCC, as well as measures preventing IASCC in light water reactors. The major information can be summarised as follows: the number of cases of damage clearly induced by IASCC is low, as compared to the damage induced by intergranular stress corrosion cracking, IGSCC. In fact, recent information from a review of documented stress corrosion cracking damage of BWR type reactor internals reveals that an increasing number of cracks formerly thought to have been caused by IASCC now can be attributed to ICSCC as the most probable cause. Generally speaking, current knowledge of the impact of ionizing radiation on the corrosion resistance of LWR materials is rather insufficient. (orig./CB) [German] Ziel des Berichts ist es, die aus internationalen Untersuchungen bekannt gewordenen wichtigsten Erkenntnisse zu Umfang, Mechanismen, Charakterisierung und Vermeidung von IASCC in Leichtwasserreaktoren zusammenzufassen. Die Ergebnisse lassen sich wie folgt zusammenfassen: Die Zahl der eindeutig auf IASCC zurueckzufuehrenden Schadensfaelle ist gering im Vergleich zur Anzahl der Schaeden infolge interkristalliner Spannungsrisskorrosion (IGSCC). Insgesamt ist bei der Beurteilung von Risslorrosionsschaeden an RDB-Einbauten in SWR in juengerer Zeit die Tendenz zu verzeichnen, dass bei Rissbildungen, welche zunaechst ursaechlich der IASCC zugeordnet wurden, zunehmend interkristalline Spannungsrisskorrosion (IGSCC) als wahrscheinliche Schadensursache in Betracht gezogen wird. Insgesamt ist der Wissensstand ueber den Einfluss ionisierender Strahlung auf das Korrosionsverhalten von LWR-Werkstoffen noch lueckenhaft. (orig./MM)

  14. Gain Efficient L-band EDFA With Dynamic Gain Equalization

    Xiaoli Hui; Rujian Lin

    2003-01-01

    A gain efficient L-band erbium-doped fiber amplifier with dynamic gain equalization is presented. Using a single fiber Bragg grating and a static equalizer, the gain is clamped at 27dB with less than 0.5dB variations over 35nm.

  15. Highly active thermally stable nanoporous gold catalyst

    Biener, Juergen; Wittstock, Arne; Biener, Monika M.; Bagge-Hansen, Michael; Baeumer, Marcus; Wichmann, Andre; Neuman, Bjoern

    2016-12-20

    In one embodiment, a system includes a nanoporous gold structure and a plurality of oxide particles deposited on the nanoporous gold structure; the oxide particles are characterized by a crystalline phase. In another embodiment, a method includes depositing oxide nanoparticles on a nanoporous gold support to form an active structure and functionalizing the deposited oxide nanoparticles.

  16. Exercise during pregnancy and its association with gestational weight gain.

    Harris, Shericka T; Liu, Jihong; Wilcox, Sara; Moran, Robert; Gallagher, Alexa

    2015-03-01

    We examined the association between exercise during pregnancy and meeting gestational weight gain recommendations. Data came from the 2009 South Carolina Pregnancy Risk Assessment Monitoring System (n = 856). Women reported their participation in exercise/sports activities before and during pregnancy, including the number of months and types of exercise. We developed an exercise index (EI), the product of the number of months spent in exercise and average metabolic equivalents for specific exercise. The 2009 Institute of Medicine's guideline was used to categorize gestational weight gain into three classes: inadequate, adequate, and excessive. Multinomial logistic regression models were used to adjust for confounders. Over 46 % of women exceeded the recommended weight gain during pregnancy. Nearly one third (31.9 %) of women reported exercising ≥3 times a week at any time during pregnancy. Compared to women who did not report this level of exercise during pregnancy, exercising women were more likely to meet gestational weight gain recommendations (32.7 vs. 18.7 %) and had a lower odds of excessive gestational weight gain [adjusted odds ratio (AOR) 0.43, 95 % confidence interval 0.24-0.78]. Women with an EI above the median value of those women who exercised or women who exercised ≥3 times a week for 6-9 months during pregnancy had lower odds of excessive gestational weight gain (AOR for EI 0.20, 0.08-0.49; AOR for months 0.26, 0.12-0.56, respectively). Our findings support the need to promote or increase exercise during pregnancy to reduce the high proportion of women who are gaining excessive weight.

  17. Low Dark-Current, High Current-Gain of PVK/ZnO Nanoparticles Composite-Based UV Photodetector by PN-Heterojunction Control

    Sang-Won Lee

    2016-01-01

    Full Text Available We propose a solution-processable ultraviolet (UV photodetector with a pn-heterojunction hybrid photoactive layer (HPL that is composed of poly-n-vinylcarbazole (PVK as a p-type polymer and ZnO nanoparticles (NPs as an n-type metal oxide. To observe the effective photo-inducing ability of the UV photodetector, we analyzed the optical and electrical properties of HPL which is controlled by the doping concentration of n-type ZnO NPs in PVK matrix. Additionally, we confirmed that the optical properties of HPL dominantly depend on the ZnO NPs from the UV-vis absorption and the photoluminescence (PL spectral measurements. This HPL can induce efficient charge transfer in the localized narrow pn-heterojunction domain and increases the photocurrent gain. It is essential that proper doping concentration of n-type ZnO NPs in polymer matrix is obtained to improve the performance of the UV photodetector. When the ZnO NPs are doped with the optimized concentration of 3.4 wt.%, the electrical properties of the photocurrent are significantly increased. The ratio of the photocurrent was approximately 103 higher than that of the dark current.

  18. Low Dark-Current, High Current-Gain of PVK/ZnO Nanoparticles Composite-Based UV Photodetector by PN-Heterojunction Control.

    Lee, Sang-Won; Cha, Seung-Hwan; Choi, Kyung-Jae; Kang, Byoung-Ho; Lee, Jae-Sung; Kim, Sae-Wan; Kim, Ju-Seong; Jeong, Hyun-Min; Gopalan, Sai-Anand; Kwon, Dae-Hyuk; Kang, Shin-Won

    2016-01-07

    We propose a solution-processable ultraviolet (UV) photodetector with a pn-heterojunction hybrid photoactive layer (HPL) that is composed of poly-n-vinylcarbazole (PVK) as a p-type polymer and ZnO nanoparticles (NPs) as an n-type metal oxide. To observe the effective photo-inducing ability of the UV photodetector, we analyzed the optical and electrical properties of HPL which is controlled by the doping concentration of n-type ZnO NPs in PVK matrix. Additionally, we confirmed that the optical properties of HPL dominantly depend on the ZnO NPs from the UV-vis absorption and the photoluminescence (PL) spectral measurements. This HPL can induce efficient charge transfer in the localized narrow pn-heterojunction domain and increases the photocurrent gain. It is essential that proper doping concentration of n-type ZnO NPs in polymer matrix is obtained to improve the performance of the UV photodetector. When the ZnO NPs are doped with the optimized concentration of 3.4 wt.%, the electrical properties of the photocurrent are significantly increased. The ratio of the photocurrent was approximately 10³ higher than that of the dark current.

  19. Application of Mathematical Modeling Activities in Costarican High School Education

    Karen Porras-Lizano

    2015-01-01

    Full Text Available This paper describes the experience gained in implementing mathematical modeling activities as a methodological strategy in teaching issues such as proportions, with a group of eighth year of an academic-day-school, located in the province of San Jose, Costa Rica in 2012. Different techniques for gathering information were applied, such as participant observation and questionnaires. Among the relevant results are the cyclical development of mathematical thinking of students in the stages of mathematical modeling (description, manipulation, prediction and validation for solving the problem; developing of teamwork skills; and appreciation of mathematics as a useful and effective discipline. To resolve the activities proposed in this study, social interactions such as sharing information, thoughts and ideas, were generated, stimulating the zone of proximal development of the participating students. Likewise, the mathematical modeling activities allowed students to have a positive role in mathematics classes, stimulating, in turn, a different attitude compared to regular classes.

  20. Structure and function relationship of toxin from Chinese scorpion Buthus martensii Karsch (BmKAGAP): gaining insight into related sites of analgesic activity.

    Cui, Yong; Guo, Gui-Li; Ma, Lin; Hu, Nan; Song, Yong-Bo; Liu, Yan-Feng; Wu, Chun-Fu; Zhang, Jing-Hai

    2010-06-01

    In this study, an effective Escherichia coli expression system was used to study the role of residues in the antitumor-analgesic peptide from Chinese scorpion Buthus martensii Karsch (BmKAGAP). To evaluate the extent to which residues of the toxin core contribute to its analgesic activity, nine mutants of BmKAGAP were obtained by PCR. Using site-directed mutagenesis, all of these residues were individually substituted by one amino acid. These were then subjected to a circular dichroism analysis, and an analgesic activity assay in mice. This study represents a thorough mapping and elucidation of the epitopes that underlie the molecular basis of the analgesic activity. The three-dimensional structure of BmKAGAP was established by homology modeling. Our results revealed large mutant-dependent differences that indicated important roles for the studied residues. With our ongoing efforts for establishing the structure and analgesic activity relationship of BmKAGAP, we have succeeded in pinpointing which residues are important for the analgesic activity.

  1. Preventing Weight Gain

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  2. 一种光伏用高升压比高效率直流变换器%A High Voltage Gain High Efficiency DC/DC Converter for PV System

    卓生荣; 皇甫宜耿

    2016-01-01

    以光伏为代表的新能源发电日益受到重视。为提高光伏发电系统的可靠性与发电效率,两级式光伏并网发电系统的前级DC/DC变换器对升压比和效率提出了要求。首先对FIBC 拓扑的工作原理、高升压性能、低电力电子器件应力等进行详细分析,与传统Boost 电路的对比结果验证了 FIBC 的优越性;然后建立了 Boost和FIBC电路的损耗模型,给出了额定工况下的损耗分布和效率,结果表明同电路参数下FIBC 具有更高的效率;接着利用交错控制技术,对FIBC 电感参数进行了优化,进一步提高变换器效率;最后给出Boost 与FIBC 和优化FIBC 在不同工作电流下的效率曲线,结果表明优化后FIBC 效率提高明显,比Boost 更适合用于低压大功率光伏发电系统中。基于Matlab/Simulink平台的仿真结果表明,使用交错技术可以优化电感参数,直流母线输出电压能够稳定在400 V。%The new energy power generation system, like the PV system, is getting more and more attention. In order to improve the reliability and efficiency of the two-level PV generation system, the high voltage gain and high efficiency of the front end is expected. The comparison result between the Floating-output Interleaved-input Boost-derived Converter(FIBC)and the Boost in voltage gain and power electronics device stress validates the superiority of the former. Then the loss models of both circuits have been presented, as well as the power distribution under the rated working condition, which shows that the FIBC is more efficient. Based on the interleaved technology, the parameter of the inductance is optimized and hence reduces the DC resistance and improves the efficiency. Finally, the efficiency versus current curve of the Boost, FIBC and the optimized FIBC is given, which shows that the FIBC is more suitable for low voltage high power PV generation system for its higher efficiency under large current

  3. A Randomized Trial on the Effect of Bone Tissue on Vibration-induced Muscle Strength Gain and Vibration-induced Reflex Muscle Activity

    2014-01-01

    Background: Whole-body vibration (WBV) induces reflex muscle activity and leads to increased muscle strength. However, little is known about the physiological mechanisms underlying the effects of whole-body vibration on muscular performance. Tonic vibration reflex is the most commonly cited mechanism to explain the effects of whole-body vibration on muscular performance, although there is no conclusive evidence that tonic vibration reflex occurs. The bone myoregulation reflex is another neuro...

  4. Active control system for high speed windmills

    Avery, D.E.

    1988-01-12

    A pump stroke is matched to the operating speed of a high speed windmill. The windmill drives a hydraulic pump for a control. Changes in speed of a wind driven shaft open supply and exhaust valves to opposite ends of a hydraulic actuator to lengthen and shorten an oscillating arm thereby lengthening and shortening the stroke of an output pump. Diminishing wind to a stall speed causes the valves to operate the hydraulic cylinder to shorten the oscillating arm to zero. A pressure accumulator in the hydraulic system provides the force necessary to supply the hydraulic fluid under pressure to drive the actuator into and out of the zero position in response to the windmill shaft speed approaching and exceeding windmill stall speed. 4 figs.

  5. Gain modulation by graphene plasmons in aperiodic lattice lasers

    Chakraborty, S.; Marshall, O. P.; Folland, T. G.; Kim, Y.-J.; Grigorenko, A. N.; Novoselov, K. S.

    2016-01-01

    Two-dimensional graphene plasmon-based technologies will enable the development of fast, compact, and inexpensive active photonic elements because, unlike plasmons in other materials, graphene plasmons can be tuned via the doping level. Such tuning is harnessed within terahertz quantum cascade lasers to reversibly alter their emission. This is achieved in two key steps: first, by exciting graphene plasmons within an aperiodic lattice laser and, second, by engineering photon lifetimes, linking graphene’s Fermi energy with the round-trip gain. Modal gain and hence laser spectra are highly sensitive to the doping of an integrated, electrically controllable, graphene layer. Demonstration of the integrated graphene plasmon laser principle lays the foundation for a new generation of active, programmable plasmonic metamaterials with major implications across photonics, material sciences, and nanotechnology.

  6. Multiphase Tertiary erosion history and elevation gain of the High Plains of New Mexico and Texas: A signal of widespread mid-Tertiary lithospheric modification?

    Landman, R.; Flowers, R. M.; Kelley, S.

    2013-12-01

    The undeformed High Plains of North America are located over 1,000 km east of the nearest plate boundary but reach elevations of >2 km at their boundary with the southern Rocky Mountains. East of the mountain front elevations decrease gradually, but remain as high as 1 km in northern Texas. Despite the accumulation of extensive geological and geophysical datasets, there is no consensus on the mechanisms that caused high elevations in the region or on how these mechanisms may be linked to the history of deformation and volcanism in the neighboring Rocky Mountains. The timing of unroofing and uplift is key to differentiating between these mechanisms, but this too remains debated. A 350 km-long integrated apatite fission-track (AFT) and (U-Th)/He (AHe) east-west transect from the southern Rocky Mountains of New Mexico across the High Plains into northern Texas provides insight into the spatial and temporal variability of unroofing across this region during Cenozoic time. The southern Sangre de Cristo Range separates the High Plains of northern New Mexico from the Rio Grande Rift. At the western edge of the southern Sangre de Cristo Range, AFT and AHe data from Precambrian basement samples show an age-elevation relationship and indicate cooling and rapid unroofing through the shallow crust during the early Tertiary Laramide orogeny. At the eastern edge of the range, both AFT and AHe data record a late Tertiary cooling episode as young as mid-Miocene. Samples from Triassic sandstones on the High Plains 50 km east of the mountain front yield mid-Tertiary AFT and late Tertiary AHe dates. These data require post-depositional heating of samples to above ~110 °C, followed by at least 1.5 km of relatively rapid unroofing on the western High Plains between 17 Ma and the initiation of Ogallala Group deposition at ~12 Ma. This interval of unroofing predates the Rio Grande Rift system. The results may therefore constrain the development of the low-velocity mantle that

  7. Gain Flattening Filter Canceling Temperature Dependence of EDFA s gain

    M.; Ohmura; Y.; Ishizawa; H.; Nakaji; K.; Hashimoto; T.; Shibata; M.; Shigehara; A.; Inoue

    2003-01-01

    We have developed a gain flattening filter (GFF) for an erbium doped fiber (EDF) without temperature control systems. This GFF, which consists of temperature-sensitive long period gratings (LPGs) and a temperature compensated slanted fiber Bragg grating (SFBG), follows the gain shift of EDF with temperature. Gain variation of the EDFA less than 0.25dBp-p was achieved with the bandwidth of 37nm, and the temperature range 0-65℃ without any temperature control systems.

  8. 基于作业成本法的医疗服务项目盈亏分析%Analysis on gain and loss of medical service project based on activity-based costing

    陈民; 王瑞云

    2016-01-01

    Analysis on gain and loss of medical service project based on activity-based costing is an important part of the establishment of refinement cost management system in hospital. Through the gain and loss analysis, hospital can improve management and operation efficiency, reduce the medical service cost, and increase the economic benefits. This paper took the department of Endocrinology ward in county hospital as an example to analyze the gain and loss of medical service project and cost structure using the activity-based costing method, to understand the reason of the cost formation, and to put forward some suggestions for improvement of medical project cost management.%基于作业成本法的医疗服务项目盈亏分析是医院建立成本精细化管理体系的重要组成部分。通过项目盈亏分析,医院可以据此改进管理,提高自身运行效率,同时降低各项医疗服务项目的成本,增加医院的经济效益。本文以县级医院内分泌科病区为例,运用作业成本法对医疗服务项目盈亏、成本构成进行分析,了解各项成本形成的原因,并据此对医疗项目成本管理提出改进建议。

  9. High resolution radar rainfall for urban pluvial flood managementmanagement: Lessons learnt from 10 pilots in North-West Europe within the RainGain project

    Ten Veldhuis, J.A.E.; Ochoa-Rodriguez, S.; Bruni, G.; Gires, A.; Van Assel, J.; Ichaba, A.; Kroll, S.; Wang, L.P.; Tchiguirinskaia, I.; Giangola Murzyn, A.; Richard, J.; Schertzer, D.; Willems, P.

    2014-01-01

    Precipitation and catchment information needs to be available at high resolution to reliably predict hydrological response and potential flooding in urban catchments. While recent advances have been made in weather radar technology and availability of DTM for urban flood modelling, the question is w

  10. A model to obtain an optimum erbium desity for gain increasing in EDFA

    E. Arzi

    2003-12-01

    Full Text Available   In this paper, we suggest a novel model, based on input pump power and wave guidestructure, to calculate the Er-density profile in Erbium doped fiber amplifiers. This optimization is carried out for both SMF and DSF fibers. These optimized profiles have a Gaussian-like shape. Using the SMF optimized Er-density profile, high gain enhancement is obtained in a relatively short length of fibers. On the other hand, the DSF optimized profile shows small changes in the gain, which agrees with the previously report on other method of gain enhancement. This model is applicable to all active waveguides and any other dopant as well .

  11. Noise Temperature Characteristics and Gain-control of Avalanche Photodiodes for Laser Radar

    CAI Xi-ping; SHANG Hong-Bo; BAI Ji-yuan; YANG Shuang; WANG Li-na

    2008-01-01

    Avalanche photodiodes(APDs) are promising light sensors with high quantum efficiency and low noise. It has been extensively used in radiation detection, laser radar and other weak signal detection fields. Unlike other photodiodes, APD is a very sensitive light detector with very high internal gain. The basic theory shows that the gain of APD is related to the temperature. The internal gain fluctuates with the variation of temperature. Investigated was the influence of the variation of the gain induced by the fluctuation of temperature on the output from APD for a very weak laser pulse input in laser radar. An active reverse-biased voltage compensation method is used to stabilize the gain of APD. An APD model is setup to simulate the detection of light pulse signal. The avalanche process, various noises and temperature's effect are all included in the model. Our results show that for the detection of weak light signal such as in laser radar, even a very small fluctuation of temperature could cause a great effect on APD's gain. The results show that the signal-to-noise ratio of the APD's output could be improved effectively with the active gain-control system.

  12. 大功率激光脉冲二极管触发高增益光导开关实验研究%Experimental study of high gain PCSS triggered by high-power pulse laser diode

    王卫; 刘毅; 谌怡; 夏连胜; 杨超; 叶茂

    2016-01-01

    A new kind of high-power pulse laser diode has been researched,and it is mainly used for triggering high-gain gallium arsenide photoconductive semiconductor switch (GaAs PCSS)in experiments.The driver of the laser diode is based on RF MOSFET and it provides an ultra-fast pulse drive current for the laser diode,and the rise-time,FWHM and peak current of the drive current are 4 ns,20 ns and 130 A,respectively.The characteristics of the laser diode have been researched,including laser pulse waveform,energy,power,optical field distribution,and so on.In the Blumlein transmission line structure,the influences of bias voltage,laser spot size,laser energy and laser power on the on-state resistance and jitter of the GaAs PCSS are analyzed. Experiment shows that,lager and more uniform laser spot,higher laser energy and power all help to improve the performance of PCSS.%研究了一种新型大功率激光脉冲二极管的输出特性,该激光二极管主要用于触发工作在高增益模式下的砷化镓光导开关。研制了基于射频金属-氧化物半导体场效应管的激光二极管驱动电路,可以为激光二极管提供上升沿、半高宽和峰值电流分别为4 ns,20 ns 和130 A 的脉冲驱动电流。研究了激光二极管输出的激光脉冲波形、能量、功率、光场分布等特性,并在 Blumlein 传输线结构中,研究了该大功率激光脉冲二极管的输出特性对工作于高增益模式下的光导开关的导通电阻、开关抖动等主要导通性能参数的影响规律。实验结果表明,激光脉冲的能量和功率越大,光斑面积越大、分布越均匀,在相同偏置电压条件下,光导开关的导通性能越好。

  13. 高频增益符号未知时的变结构模型参考自适应控制%Variable Structure Model Reference Adaptive Control with Unknown High Frequency Gain Sign

    董文瀚; 孙秀霞; 林岩

    2007-01-01

    A variable structure model reference adaptive control for plants with relative degree greater than one and unknown high frequency gain sign is proposed. A switching scheme is introduced based on a monitoring function designed for the first auxiliary error of the close loop system. It is shown that under the supervision of the monitoring function, the switching stops after at most a finite number of switchings and the tracking error converges to a residual set that can be made arbitrarily small by appropriately choosing some design parameters.

  14. Non-isolated DC-AC converter with high voltage gain for autonomous systems of electric power; Conversor CC-CA nao isolado com alto ganho de tensao para aplicacao em sistemas autonomos de energia eletrica

    Silveira, George Cajazeiras [Centro Federal de Educacao Tecnologica do Ceara (CEFET/CE), Fortaleza, CE (Brazil); Torrico-Bascope, Rene P. [Universidade Federal do Ceara (PPGEE/UFC), Fortaleza, CE (Brazil). Programa de Pos Graduacao em Engenharia Eletrica; Borges Neto, Manuel Rangel [Centro Federal de Educacao Tecnologica de Petrolina (CEFET-PET), PE (Brazil)

    2008-07-01

    A non-isolated DC-AC converter with high voltage gain with two output sinusoidal voltage - 110 V and 220 V - and frequency 60 Hz for application in autonomous systems of electric power is proposed in this work. This topology consists of a boost converter with high voltage gain, based on three-state switching cell combined with a double half bridge inverter. This configuration type the size and the cost are reduced and the efficiency is gotten better, due to the reduced number of switches. The converters that compose this topology operate with high frequency, reducing the volume of the magnetic materials. can be mention as important characteristics: the voltage stress across the switches of the boost converter are low, due they be naturally clamped by one output filter capacitor, which allows the utilization of switches with lower conduction resistances, and the waveforms of the output voltage of the double half bridge inverter supplies for the load it is sinusoidal and it possesses low harmonic content. (author)

  15. Gaining a Bigger Say

    DING YING

    2010-01-01

    @@ Finance ministers and central bank govemors from the Group of 20 (G20) major economies agreed on October 23 to shift more than 6 percent of the Intemational Monetary Fund (IMF) quotas to emerging or underrepresented countries.According to the agreement, signed in Gyeongju in the Republic of Korea, China's new quota in the IMF will be the third high-est in the world.

  16. Metallomics for drug development: a further insight into intracellular activation chemistry of a ruthenium(III)-based anticancer drug gained using a multidimensional analytical approach.

    Matczuk, Magdalena; Prządka, Monika; Aleksenko, Svetlana S; Czarnocki, Zbigniew; Pawlak, Katarzyna; Timerbaev, Andrei R; Jarosz, Maciej

    2014-01-01

    The mechanism by which the most relevant ruthenium anticancer drugs are activated in tumors to commence their tumor-inhibiting action remains one of the challenging research tasks of present-day metallomics. This contribution aims to capture and identify eventually more reactive species of one of two bis-indazole tetrachloridoruthenate(III) compounds that are progressing in clinical trials. In view of the fact that the transport of ruthenium into cancer cells is governed by transferrin receptors, the susceptibility of the Ru drug adduct with holo-transferrin to exposure by glutathione and ascorbic acid (at their cancer cytosol concentrations) was studied by inductively coupled plasma mass spectrometry (ICP-MS), following isolation of the reaction products by ultrafiltration. Next, capillary electrophoresis coupled to ICP-MS was applied to monitor changes in the Ru speciation both under simulated cancer cytosol conditions and in real cytosol and to assign the charge state of novel metal species. The latter were identified by using tandem electrospray ionization MS in the respective ion mode. The formation of ruthenium(II) species was for the first time revealed, in which the central metal is coordinated by the reduced (GSH) or the oxidized (GSSG) form of glutathione, i.e. [Ru(II)HindCl4(GSH)](2-) and [Ru(II)HindCl4(GSSG)](2-), respectively (Hind = indazole). Ascorbic acid released the ruthenium functionality from the protein-bound form in a different way, the products of adduct cleavage containing aqua ligands. Distribution of low-molecular mass species of Ru in human cytosol was found to have very much in common with the ruthenium speciation assayed under simulated cytosol conditions.

  17. Fetal Programming of Obesity: Maternal Obesity and Excessive Weight Gain

    Seray Kabaran

    2014-01-01

    The prevalence of obesity is an increasing health problem throughout the world. Maternal pre-pregnancy weight, maternal nutrition and maternal weight gain are among the factors that can cause childhood obesity. Both maternal obesity and excessive weight gain increase the risks of excessive fetal weight gain and high birth weight. Rapid weight gain during fetal period leads to changes in the newborn body composition. Specifically, the increase in body fat ratio in the early periods is associat...

  18. Low gain and steerable vehicle antennas for communications with land mobile satellite

    Woo, K.

    1982-01-01

    Current development activities at JPL for ground mobile vehicle antennas to be used with the Land Mobile Satellite Service (LMSS) system are described. Both low gain and electronically steerable high gain type antennas are discussed in terms of their design concept and RF performance. For the low gain type, three classes of antennas are under various stages of development. These are the crossed-drooping dipole, quadrifilar helix, and microstrip patch designs. The antennas are intended to provide circularly-polarized radiation with a minimum of 3-dB gain in the angular region from 19 degrees to 60 deg from the horizon in elevation plane and with an omnidirectional pattern in azimuthal plane. For the electronically steerable high gain type, circularly-polarized microstrip patch phased arrays formed on a planar surface and on the surface of a truncated cone are under study. The arrays are intended to provide a minimum of 12 dB gain in the same angular region in elevation plane at all azimuthal angles. This coverage is accomplished by scanning the high gain pencil beam in both elevation and azimuthal directions. Both types of antennas are to transmit at 821-831 MHz band and to receive at 866-876 MHz band. They must be of low cost design and reasonably conformal to the vehicle.

  19. The V1 Population Gains Normalization

    Ganmor, Elad; Okun, Michael; Lampl, Ilan

    2009-01-01

    In this issue of Neuron, Busse et al. describe the population response to superimposed visual stimuli while Sit et al. examine the spatiotemporal evolution of cortical activation in response to small visual stimuli. Surprisingly, these two studies of V1 report that a single gain control model accoun

  20. Catalytically highly active top gold atom on palladium nanocluster.

    Zhang, Haijun; Watanabe, Tatsuya; Okumura, Mitsutaka; Haruta, Masatake; Toshima, Naoki

    2011-10-23

    Catalysis using gold is emerging as an important field of research in connection with 'green' chemistry. Several hypotheses have been presented to explain the markedly high activities of Au catalysts. So far, the origin of the catalytic activities of supported Au catalysts can be assigned to the perimeter interfaces between Au nanoclusters and the support. However, the genesis of the catalytic activities of colloidal Au-based bimetallic nanoclusters is unclear. Moreover, it is still a challenge to synthesize Au-based colloidal catalysts with high activity. Here we now present the 'crown-jewel' concept (Supplementary Fig. S1) for preparation of catalytically highly Au-based colloidal catalysts. Au-Pd colloidal catalysts containing an abundance of top (vertex or corner) Au atoms were synthesized according to the strategy on a large scale. Our results indicate that the genesis of the high activity of the catalysts could be ascribed to the presence of negatively charged top Au atoms.

  1. Identification of highly active flocculant proteins in bovine blood.

    Piazza, George J; Nuñez, Alberto; Garcia, Rafael A

    2012-03-01

    Synthetic polymeric flocculants are used extensively for wastewater remediation, soil stabilization, and reduction in water leakage from unlined canals. Sources of highly active, inexpensive, renewable flocculants are needed to replace synthetic flocculants. High kaolin flocculant activity was documented for bovine blood (BB) and blood plasma with several anticoagulant treatments. BB serum also had high flocculant activity. To address the hypothesis that some blood proteins have strong flocculating activity, the BB proteins were separated by SEC. Then, the major proteins of the flocculant-active fractions were separated by SDS-PAGE. Identity of the major protein components was determined by tryptic digestion and peptide analysis by MALDI TOF MS. The sequence of selected peptides was confirmed using TOF/TOF-MS/MS fragmentation. Hemoglobin dimer (subunits α and β) was identified as the major protein component of the active fraction in BB; its high flocculation activity was confirmed by testing a commercial sample of hemoglobin. In the same manner, three proteins from blood plasma (fibrinogen, γ-globulin, α-2-macroglobulin) were found to be highly active flocculants, but bovine serum albumin, α-globulin, and β-globulin were not flocculants. On a mass basis, hemoglobin, γ-globulin, α-2-macroglobulin were as effective as anionic polyacrylamide (PAM), a widely used synthetic flocculant. The blood proteins acted faster than PAM, and unlike PAM, the blood proteins flocculants did not require calcium salts for their activity.

  2. Experimental studies of high order soliton compression effect and gain characteristics in femtosecond laser pulses E3+r-doped fiber amplifier

    2000-01-01

    Seed laser pulses with average power of 146 μW and pulse duration of 480 fs were amplified to 14.5 mW. The pulse duration was compressed to 260 fs using 6 m high concentration E3+r-doped fiber under forward pumping. The amplified signal pulse energy was 0.691 nJ (corresponding to a peak power of 2 657.7 W) and the repetition rate was 20.84 MHz. Spectrum breakup was observed simultaneously. The spectrum of pulses amplified by 3 m E3+r-doped fiber remains a single peak under different pump power. The amplified pulse duration was compressed abnormally with the increasing pump power using the backward pumping; that is, the amplified pulses were compressed with the increasing pump power under low pump power. When the pump power reached 38 mW, the shortest amplified pulse duration was 309 fs. With further increase in pump power, the amplified pulses began broadening, accompanied by a single peak spectrum under different pump power.

  3. Effect of Weight Gain on Cardiac Autonomic Control During Wakefulness and Sleep

    Adachi, Taro; Sert-Kuniyoshi, Fatima H.; Calvin, Andrew D.; Singh, Prachi; Romero-Corral, Abel; van der Walt, Christelle; Davison, Diane E.; Bukartyk, Jan; Konecny, Tomas; Pusalavidyasagar, Snigdha; Sierra-Johnson, Justo; Somers, Virend K.

    2012-01-01

    Obesity has been associated with increased cardiac sympathetic activation during wakefulness, but the effect on sleep-related sympathetic modulation is not known. The aim of this study was to investigate the effect of fat gain on cardiac autonomic control during wakefulness and sleep in humans. We performed a randomized controlled study to assess the effects of fat gain on heart rate variability (HRV). We recruited 36 healthy volunteers, who were randomized to either a standardized diet to gain approximately 4 kg over 8 weeks followed by an 8 week weight loss period (n=20), or to serve as a weight-maintainer control (n=16). An overnight polysomnogram with power spectral analysis of HRV was performed at baseline, after weight gain, and after weight loss to determine the ratio of low frequency (LF) to high frequency (HF) power, and to examine the relationship between changes in HRV and changes in insulin, leptin and adiponectin levels. Mean weight gain was 3.9 kg in the fat gain group versus 0.1 kg in the maintainer group. LF/HF increased both during wakefulness and sleep after fat gain and returned to baseline after fat loss in the fat gain group, and did not change in the control group. Insulin, leptin and adiponectin also increased after fat gain and fell after fat loss, but no clear pattern of changes were seen that correlated consistently with changes in HRV. Short-term fat gain in healthy subjects is associated with increased cardiac sympathetic activation during wakefulness and sleep but the mechanisms remain unclear. PMID:21357280

  4. Gain Flattening Filter Canceling Temperature Dependence of EDFA's gain

    M. Ohmura; Y. Ishizawa; H. Nakaji; K. Hashimoto; T. Shibata; M. Shigehara; A. Inoue

    2003-01-01

    We have developed a gain flattening filter(GFF) for an erbium doped fiber (EDF) without temperature control systems. This GFF, which consists of temperature-sensitive long period gratings (LPGs)and a temperature compensated slanted fiber Bragg grating (SFBG), follows the gain shift of EDF with temperature. Gain variation of the EDFA less than 0.25dBp-p was achieved with the bandwidth of 37nm,and the temperature range 0-65℃ without and temperature control systems.

  5. High Resolution Screening of biologically active compounds and metabolites

    Kool, J.

    2007-01-01

    High Resolution Screening of biologically active compounds and metabolites Jeroen Kool Biotransformation enzymes play a crucial role in the metabolism of both endogenous compounds and xenobiotics. Usually, the detoxication of these compounds by biotransformation enzymes results in harmless metab

  6. Murine erythrocytes contain high levels of lysophospholipase activity

    Kamp, J.A.F. op den; Roelofsen, B.; Sanderink, G.; Middelkoop, E.; Hamer, R.

    1984-01-01

    Murine erythrocytes were found to be unique in the high levels of lysophospholipase activity in the cytosol of these cells. The specific activity of the enzyme in the cytosol of the murine cells is 10-times higher than in the cytosol of rabbit erythrocytes and approximately three orders of magnitude

  7. Spectroscopic investigations of dispersion-shifted fiber with thin active Bi-doped ring and high nonlinear refractive index

    Zlenko, A. S.; Akhmetshin, U. G.; Bogatyrjov, V. A.; Bulatov, L. I.; Dvoyrin, V. V.; Firstov, S. V.; Dianov, E. M.

    2009-10-01

    A germanium-doped silica-core fiber with an active region in the form of a thin ring of silica doped with bismuth ions was fabricated. Bismuth doping in the ring surrounding the core allows to stabilize bismuth in silica glass, and it does not impose any restrictions on the composition of the core. The bismuth concentration in the ring is less than 0.2 wt.%. The GeO2 concentration in the core is more than 15 mol.%. A high germanium concentration in the core allows to shift the zero dispersion wavelength to 1860 nm and to obtain a high nonlinear refractive index (n2 more than 3,2*10-20 m2/W). Spectroscopic investigations were carried out in the visible and near infrared (800-1700 nm) spectral range. Despite the small concentration of bismuth, we observed the absorption and luminescence characteristic bands, confirming the presence of bismuth active centers in silica glass. Upon pumping at 1350 nm the on/off gain spectrum was measured on a 20-m fiber. The gain was observed throughout investigated range of 1430-1530 nm. The maximal gain of ~9.5 dB was obtained near 1430 nm. The results of the spectroscopic investigations of the fiber with a thin active Bi-doped ring showed prospects of the creation and application of such fiber type for laser and nonlinear optics.

  8. Speech perception of noise with binary gains

    Wang, DeLiang; Kjems, Ulrik; Pedersen, Michael Syskind;

    2008-01-01

    For a given mixture of speech and noise, an ideal binary time-frequency mask is constructed by comparing speech energy and noise energy within local time-frequency units. It is observed that listeners achieve nearly perfect speech recognition from gated noise with binary gains prescribed...... by the ideal binary mask. Only 16 filter channels and a frame rate of 100 Hz are sufficient for high intelligibility. The results show that, despite a dramatic reduction of speech information, a pattern of binary gains provides an adequate basis for speech perception....

  9. Microstrip antenna gain enhancement with metamaterial radome

    Attachi, S.; Saleh, C.; Bouzouad, M.

    2017-01-01

    In this work, a high gain patch antenna using multilayer FSS radome is proposed for millimeter-wave applications. The antenna operating frequency is 43.5 GHz. The antenna/radome system consists of one, two, three, or four layers of metasurfaces placed in the near-field region of a microstrip patch antenna. The antenna/radome system gain is improved by 9 dBi compared to the patch antenna alone, and the radiation pattern half-power beamwidth is reduces to 20° in both E- and H-planes.

  10. [Atypical antipsychotic-induced weight gain].

    Godlewska, Beata R; Olajossy-Hilkesberger, Luiza; Marmurowska-Michałowska, Halina; Olajossy, Marcin; Landowski, Jerzy

    2006-01-01

    Introduction of a new group of antipsychotic drugs, called atypical because of the proprieties differing them from classical neuroleptics, gave hope for the beginning of a new era in treatment of psychoses, including schizophrenia. Different mechanisms of action not only resulted in a broader spectrum of action and high efficacy but also in a relative lack of extrapiramidal symptoms. However, atypical neuroleptics are not totally free from adverse effects. Symptoms such as sedation, metabolic changes and weight gain, often very quick and severe - present also in the case of classical drugs, but put to the background by extrapiramidal symptoms--have become prominent. Weight gain is important both from the clinical and subjective point of view--as associated with serious somatic consequences and as a source of enormous mental distress. These problems are addressed in this review, with the focus on weight gain associated with the use of specific atypical neuroleptics.

  11. Seasonal Variations of Cell Site Diversity Gain

    Sharmini Enoch

    2016-08-01

    Full Text Available The broadband fixed wireless access (BFWA systems operate in microwave frequencies. In this frequency range, the wave propagation is highly influenced by precipitation caused especially by rain. With the use of cell site diversity (CSD, the rain attenuation effects can be mitigated. When the signal level falls below a certain threshold the subscriber station switches to another base station within the coverage area. This paper aims at demonstrating the performance improvements obtained with the use of cell site diversity during various seasons for measurements carried out from HYREX rain gauge network in UK. The parameters traditionally used to quantify cell site diversity are CSD gain and diversity improvement. This paper analyzes the CSD gain achieved. The gain increases with increasing frequency and distance. The link performance is compared for various seasons and the results show that the maximum attenuation occurs during summer, while the least attenuation occurs during winter. Therefore, maximum gain of up to 22 dB occurs at 54 GHz frequency during winter. The second observation is that when the angular separation between the diversity sites is 180° separation there is maximum gain for all seasons.

  12. CONDITIONS FOR CSR MICROBUNCHING GAIN SUPPRESSION

    Tsai, Cheng Ying [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Douglas, David R. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Li, Rui [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Tennant, Christopher D. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); di Mitri, Simone [Elettra–Sincrotrone Trieste, 34149 Basovizza, Trieste, Italy

    2016-05-01

    The coherent synchrotron radiation (CSR) of a high brightness electron beam traversing a series of dipoles, such as transport arcs, may result in phase space degradation. On one hand, the CSR can perturb electron transverse motion in dispersive regions along the beamline, causing emittance growth. On the other hand, the CSR effect on the longitudinal beam dynamics could result in microbunching gain enhancement. For transport arcs, several schemes have been proposed* to suppress the CSR-induced emittance growth. Similarly, several scenarios have been introduced** to suppress CSR-induced microbunching gain, which however mostly aim for linac-based machines. In this paper we try to provide sufficient conditions for suppression of CSR-induced microbunching gain along a transport arc, analogous to*. Several example lattices are presented, with the relevant microbunching analyses carried out by our semi-analytical Vlasov solver***. The simulation results show that lattices satisfying the proposed conditions indeed have microbunching gain suppressed. We expect this analysis can shed light on lattice design approach that could suppress the CSR-induced microbunching gain.

  13. Diversity Gain through Antenna Blocking

    V. Dehghanian

    2012-01-01

    Full Text Available As part of the typical usage mode, interaction between a handheld receiver antenna and the operator's RF absorbing body and nearby objects is known to generate variability in antenna radiation characteristics through blocking and pattern changes. It is counterintuitive that random variations in blocking can result in diversity gain of practical applicability. This diversity gain is quantified from a theoretical and experimental perspective. Measurements carried out at 1947.5 MHz verify the theoretical predictions, and a diversity gain of 3.1 dB was measured through antenna blocking and based on the utilized measurement setup. The diversity gain can be exploited to enhance signal detectability of handheld receivers based on a single antenna in indoor multipath environments.

  14. Experimental conditions affecting functional comparison of highly active glutathione transferases.

    Fedulova, Natalia; Mannervik, Bengt

    2011-06-01

    Glutathione transferases (GSTs, EC 2.5.1.18) possess multiple functions and have potential applications in biotechnology. Direct evidence of underestimation of activity of human GST A3-3 and porcine GST A2-2 measured at submicromolar enzyme concentrations is reported here for the first time. The combination of time-dependent and enzyme concentration-dependent loss of activity and the choice of the organic solvent for substrates were found to cause irreproducibility of activity measurements of GSTs. These effects contribute to high variability of activity values of porcine GST A2-2 and human Alpha-class GSTs reported in the literature. Adsorption of GSTs to surfaces was found to be the main explanation of the observed phenomena. Several approaches to improved functional comparison of highly active GSTs are proposed.

  15. Developmental gains in visuospatial memory predict gains in mathematics achievement.

    Yaoran Li

    Full Text Available Visuospatial competencies are related to performance in mathematical domains in adulthood, but are not consistently related to mathematics achievement in children. We confirmed the latter for first graders and demonstrated that children who show above average first-to-fifth grade gains in visuospatial memory have an advantage over other children in mathematics. The study involved the assessment of the mathematics and reading achievement of 177 children in kindergarten to fifth grade, inclusive, and their working memory capacity and processing speed in first and fifth grade. Intelligence was assessed in first grade and their second to fourth grade teachers reported on their in-class attentive behavior. Developmental gains in visuospatial memory span (d = 2.4 were larger than gains in the capacity of the central executive (d = 1.6 that in turn were larger than gains in phonological memory span (d = 1.1. First to fifth grade gains in visuospatial memory and in speed of numeral processing predicted end of fifth grade mathematics achievement, as did first grade central executive scores, intelligence, and in-class attentive behavior. The results suggest there are important individual differences in the rate of growth of visuospatial memory during childhood and that these differences become increasingly important for mathematics learning.

  16. Developmental gains in visuospatial memory predict gains in mathematics achievement.

    Li, Yaoran; Geary, David C

    2013-01-01

    Visuospatial competencies are related to performance in mathematical domains in adulthood, but are not consistently related to mathematics achievement in children. We confirmed the latter for first graders and demonstrated that children who show above average first-to-fifth grade gains in visuospatial memory have an advantage over other children in mathematics. The study involved the assessment of the mathematics and reading achievement of 177 children in kindergarten to fifth grade, inclusive, and their working memory capacity and processing speed in first and fifth grade. Intelligence was assessed in first grade and their second to fourth grade teachers reported on their in-class attentive behavior. Developmental gains in visuospatial memory span (d = 2.4) were larger than gains in the capacity of the central executive (d = 1.6) that in turn were larger than gains in phonological memory span (d = 1.1). First to fifth grade gains in visuospatial memory and in speed of numeral processing predicted end of fifth grade mathematics achievement, as did first grade central executive scores, intelligence, and in-class attentive behavior. The results suggest there are important individual differences in the rate of growth of visuospatial memory during childhood and that these differences become increasingly important for mathematics learning.

  17. 一种带有增益提高技术的高速CMOS运算放大器设计%Design of a high speed CMOS operational amplifier with gain boosting technique

    宋奇伟; 陆安江; 张正平

    2012-01-01

    设计了一种用于高速ADC中的高速高增益的全差分CMOS运算放大器。主运放采用带开关电容共模反馈的折叠式共源共栅结构,利用增益提高和三支路电流基准技术实现一个可用于12~14 bit精度,100 MS/s采样频率的高速流水线(Pipelined)ADC的运放。设计基于SMIC 0.25μm CMOS工艺,在Cadence环境下对电路进行Spectre仿真。仿真结果表明,在2.5 V单电源电压下驱动2 pF负载时,运放的直流增益可达到124 dB,单位增益带宽720 MHz,转换速率高达885 V/μs,达到0.1%的稳定精度的建立时间只需4 ns,共模抑制比153 dB。%A fully differential opamp used in a high speed ADC was designed.The main amplifier is a folded cascode amplifier with SC CMFB.The opamp can be used in a 12 bit、100MS/s high speed Pipelined ADC with gain boosting and the triple-branch current reference technique.The operational amplifier is implemented in a standard 0.25 μm CMOS process,simulated with Spectre under Cadence.With 2.5 V power supply and 2 pF load capacitance has a DC gain of 124 dB,a unity gain bandwidth of 720 MHz,Slew Rate of 885 V/μs,4 ns settling time and 153dB CMRR.

  18. Super-SERS-active and highly effective antimicrobial Ag nanodendrites

    Li, H. B.; Liu, P.; Liang, Y.; Xiao, J.; Yang, G. W.

    2012-07-01

    We have developed simple and green electrochemistry to synthesize Ag nanostructures with high purity, good crystallinity and smooth surface for applications as super-SERS (surface-enhanced Raman scattering), SERS-active substrates and with highly effective antimicrobial activities. This synthesis takes place in a clean and slow reaction environment without any chemical additives, which ensures an ultrahigh active surface of the as-synthesized Ag nanostructures owing to their purity, good crystallinity and smooth morphology. Using this method, we synthesized nearly perfect Ag nanodendrites (NDs), which exhibit super-SERS sensitivity when they are used to detect the SERS spectra of rhodamine 6G at concentrations as low as 5 × 10-16 M, and have an ultrahigh electromagnetic (EM) enhancement factor of the order of 1013, breaking through the theoretical limit of EM enhancement. Meanwhile, the as-synthesized Ag NDs possess highly effective antimicrobial activities for Escherichia coli, Candida albicans and Staphylococcus aureus, which are over 10 times that of silver nanoparticles. Additionally, the basic physics and chemistry involved in the fabrication of Ag nanostructures are pursued. These investigations show that silver nanostructures with highly active surfaces can make the most of Ag nanostructures functioning as super-SERS-active substrates and multiple antibiotics.

  19. Compensatory weight gain due to dopaminergic hypofunction: new evidence and own incidental observations

    Bohr Iwo

    2008-12-01

    Full Text Available Abstract There is increasing evidence for a role of dopamine in the development of obesity. More specifically, dopaminergic hypofunction might lead to (overcompensatory food intake. Overeating and resulting weight gain may be induced by genetic predisposition for lower dopaminergic activity, but might also be a behavioral mechanism of compensating for decreased dopamine signaling after dopaminergic overstimulation, for example after smoking cessation or overconsumption of high palatable food. This hypothesis is in line with our incidental finding of increased weight gain after discontinuation of pharmaceutical dopaminergic overstimulation in rats. These findings support the crucial role of dopaminergic signaling for eating behaviors and offer an explanation for weight-gain after cessation of activities associated with high dopaminergic signaling. They further support the possibility that dopaminergic medication could be used to moderate food intake.

  20. Recommendations of activity restriction in high-risk pregnancy scenarios

    Bendix, Jane; Hegaard, Hanne Kristine; Bergholt, Thomas;

    2015-01-01

    obstetricians and midwives prescribe activity restriction in most high-risk pregnancies. The degree of activity restriction and the presumed effect vary between clinicians. This may reflect different attitudes and lack of guidelines based on clinical studies of a possible benefit of activity restriction....... to the obstetricians, the midwives also reported that they expected the recommendation to be more effective. Most midwives and obstetricians reported that they thought strict activity restriction was associated with severe or moderate adverse effect, and recommended antithrombotic prophylaxis. Conclusions: Danish......Abstract Aims: To describe specific recommendations of activity restriction, place of care, expected beneficial and adverse effects, and recommended antithrombotic prophylaxis in nine clinical scenarios. Methods: A national survey. All members of the Danish Society of Obstetrics and Gynaecology...

  1. High lightning activity in maritime clouds near Mexico

    B. Kucienska

    2012-01-01

    Full Text Available Lightning activity detected by the World Wide Lightning Location Network (WWLLN over oceanic regions adjacent to Mexico is often as high as that observed over the continent. In order to explore the possible cause of the observed high flash density over those regions, the relationships between lightning, rainfall, vertical hydrometeor profiles, latent heating, wind variability and aerosol optical thickness are analyzed. The characteristics of lightning and precipitation over four oceanic zones adjacent to Mexican coastlines are contrasted against those over the continent. In addition, we compare two smaller regions over the Tropical Pacific Ocean: one located within the Inter-Tropical Converge Zone and characterized by high rainfall and weak lightning activity and the other influenced by a continental jet and presenting high rainfall and strong lightning activity over the Gulf of Tehuantepec. Maritime precipitating clouds that develop within the region influenced by offshore winds exhibit similar properties to continental clouds: large content of precipitation ice and an increased height range of coexistence of precipitation ice and cloud water. During the rainy season, monthly distribution of lightning within the region influenced by the continental jet is contrary to that of rainfall. Moreover, the monthly variability of lightning is very similar to the variability of the meridional wind component and it is also related to the variability of aerosol optical depth. The analysis strongly suggests that the high lightning activity observed over the Gulf of Tehuantepec is caused by continental cloud condensation nuclei advected over the ocean.

  2. 超高频射频识别小间隔双标签天线增益特性研究%Study on Gain Characteristics of Dual Ultra-high-frequency Radio Frequency Identification Tag Antennas with Small Interval

    彭章友; 任秀方; 孟春阳; 李帅

    2015-01-01

    Parameters of the Ultra-High-Frequency Radio Frequency IDentification (UHF RFID) tags and the mutual coupling effect have great impact on antenna gain, and a corresponding theoretical model is developed. Firstly, from the perspective of the radiation field, the tag is equivalent to dipole antenna with lumped load. Then based on the theory of dipole array, a simplified gain model of dual tag antennas with small interval is derived, and application of multiple tags is expanded simply. The simulation results show that the model is effective. Finally, the directivity and radiation efficiency are studied. The results provide a theoretical guidance for the research of intensive tags performance.%该文针对超高频射频识别(UHF RFID)标签自身参数和标签间互相耦合对标签天线增益的影响,推导了相应的理论模型。首先从辐射场的角度将标签等效为带集总负载的对称振子天线,然后基于对称振子天线阵列的理论建立了小间隔双标签天线增益的简化模型,并对密集多标签应用场合进行了简单拓展,仿真研究验证了所建模型的有效性。最后对增益的方向性和辐射效率进行了研究,研究结果对密集标签的性能研究具有一定的指导意义。

  3. Stacked Transformer for Driver Gain and Receive Signal Splitting

    Driscoll, Kevin R.

    2013-01-01

    In a high-speed signal transmission system that uses transformer coupling, there is a need to provide increased transmitted signal strength without adding active components. This invention uses additional transformers to achieve the needed gain. The prior art uses stronger drivers (which require an IC redesign and a higher power supply voltage), or the addition of another active component (which can decrease reliability, increase power consumption, reduce the beneficial effect of serializer/deserializer preemphasis or deemphasis, and/or interfere with fault containment mechanisms), or uses a different transformer winding ratio (which requires redesign of the transformer and may not be feasible with high-speed signals that require a 1:1 winding ratio). This invention achieves the required gain by connecting the secondaries of multiple transformers in series. The primaries of these transformers are currently either connected in parallel or are connected to multiple drivers. There is also a need to split a receive signal to multiple destinations with minimal signal loss. Additional transformers can achieve the split. The prior art uses impedance-matching series resistors that cause a loss of signal. Instead of causing a loss, most instantiations of this invention would actually provide gain. Multiple transformers are used instead of multiple windings on a single transformer because multiple windings on the same transformer would require a redesign of the transformer, and may not be feasible with high-speed transformers that usually require a bifilar winding with a 1:1 ratio. This invention creates the split by connecting the primaries of multiple transformers in series. The secondary of each transformer is connected to one of the intended destinations without the use of impedance-matching series resistors.

  4. Welfare Gains from Financial Liberalization.

    Townsend, Robert M; Ueda, Kenichi

    2010-08-01

    Financial liberalization has been a controversial issue, as empirical evidence for growth enhancing effects is mixed. Here, we find sizable welfare gains from liberalization (cost to repression), though the gain in economic growth is ambiguous. We take the view that financial liberalization is a government policy that alters the path of financial deepening, while financial deepening is endogenously chosen by agents given a policy and occurs in transition towards a distant steady state. This history-dependent view necessitates the use of simulation analysis based on a growth model. Our application is a specific episode: Thailand from 1976 to 1996.

  5. Reduced autonomic activity during stepwise exposure to high altitude

    Sevre, K; Bendz, B; Hanko, E; Nakstad, AR; Hauge, A; Kasin, JI; Lefrandt, JD; Smit, AJ; Eide, [No Value; Rostrup, M

    2001-01-01

    Several studies have shown increased sympathetic activity during acute exposure to hypobaric hypoxia. In a recent field study we found reduced plasma catecholamines during the first days after a stepwise ascent to high altitude. In the present study 14 subjects were exposed to a simulated ascent in

  6. Physical Activity in High School during "Free-Time" Periods

    Silva, Pedro; Sousa, Michael; Sá, Carla; Ribeiro, José; Mota, Jorge

    2015-01-01

    The purpose of this study was to examine youth physical activity (PA) in free-time periods during high school days and their contribution to total PA. Differences in terms of sex, age, body mass index and school level were assessed in a sample of Portuguese adolescents. Participants totalled 213 (135 girls), aged 14.6 ± 1.7, from two different…

  7. Pregnancy weight gain and postpartum loss: avoiding obesity while optimizing the growth and development of the fetus.

    Lederman, S A

    2001-01-01

    Weight gain during pregnancy may contribute to obesity development. Concerns about possible adverse effects of pregnancy weight gain on later maternal weight and on labor and delivery must be rigorously evaluated in light of possible benefits for fetal growth and development. Birth-weight rises with increased pregnancy weight gain, and perinatal and neonatal mortality fall as birthweight increases in both preterm and term infants. The lowest mortality is observed at 3500 to 4500 g in infants of white women. Although often thought to be at high risk, infants termed "macrosomic" include infants of the lowest mortality rate. Thus, restricting weight gain may be detrimental to the baby. Weight gain that is optimal for the mother and the baby differs according to the mother's prepregnancy weight. Pregnancy weight gain exceeding current recommendations is associated with increases in maternal fat gain, pregnancy complications, and delivery problems and should be discouraged. Postpartum weight loss is essential to prevent permanent weight increase. Smoking cessation during pregnancy, reduced postpartum physical activity, and other lifestyle changes can contribute to increased postpartum weight. Health care providers can help to reduce obesity risk by regularly monitoring women's weight; promoting appropriate prepregnancy weight, pregnancy weight gain, and postpartum weight less; and explicitly encouraging maintenance of an active postpartum lifestyle.

  8. Development activities of the high heat flux scraper element

    Boscary, J., E-mail: jean.boscary@ipp.mpg.de [Max Planck Institute for Plasma Physics, Garching (Germany); Lore, J.; Lumsdaine, A. [Oak Ridge National Laboratory, Oak Ridge, TN (United States); Maier, M. [Max Planck Institute for Plasma Physics, Garching (Germany); McGinnis, D. [Oak Ridge National Laboratory, Oak Ridge, TN (United States); Peacock, A.; Tretter, J. [Max Planck Institute for Plasma Physics, Garching (Germany)

    2015-10-15

    The function of the high heat flux scraper element is to reduce the heat loads on the element ends of the actively cooled divertor of Wendelstein 7-X. The scraper element is actively water cooled to remove up to 550 kW steady state power load, with localized heat fluxes as high as 20 MW/m{sup 2}. Its surface area, 0.17 m{sup 2}, is contoured to optimally intercept both upstream and downstream particle fluxes. The plasma facing surface is made of 24 individual scraper fingers based on the monoblock technology. Each scraper finger is 247 mm long and 28 mm wide and has 13 monoblocks made of CFC NB31 bonded by hot isostatic pressing onto a CuCrZr cooling tube equipped with a copper twisted tape. Development activities, described here, include the design and fabrication of prototypes to validate the different technologies selected for the scraper element design to prepare a possible production.

  9. Stress effects on framed decisions: there are differences for gains and losses

    Stephan ePabst

    2013-10-01

    Full Text Available Recent studies have shown that acute stress can lead to riskier decision making. Yet, the underlying mechanisms of the stress effects on decisions under risk remain poorly understood. To gain a better understanding of decision-making processes and potential strategy application under stress, we investigated decision making in pure gain and loss domains with unequal expected values across alternatives. We conducted an experimental study with a 2 × 2 design (stress vs. no stress and gain domain vs. loss domain. The Trier Social Stress Test (TSST was utilized to induce acute stress. Controls performed the placebo-TSST. To validate the stress response we measured salivary cortisol and alpha amylase concentrations. We used a modified version of the Game of Dice Task (GDT to assess decision-making performance in a gain and a loss domain. Results showed that non-stressed participants of the gain domain decided less risky compared to those of the loss domain. This behavior is in accordance with previous studies and indicates the stability of the framing effect in even more complex tasks with changing expected values across alternatives. Stress did not alter risk taking behavior in the gain domain. Yet, in the loss domain stressed participants decided less risky compared to controls. Additionally, the data support earlier findings of longer reaction times in loss compared to gain domains due to higher cognitive effort for loss-framed decisions. It is discussed that stress may lead to reduced amygdala activation, which has been found to reduce riskier decisions in a loss domain. With respect to earlier results of riskier decisions in tasks that unite both gain and loss domains, it is discussed whether stress leads to a stronger evaluation of high gains and a neglect of losses.

  10. Review of actuators for high speed active flow control

    WANG Lin; LUO ZhenBing; XIA ZhiXun; LIU Bing; DENG Xiong

    2012-01-01

    Actuators are one of the key points for the development of active flow control technology.Efficient methods of high speed flow control can provide enhanced propulsive efficiency and at the same time enable safe and maneuverable high speed flight.The development of high speed flight technology promotes the emergence of novel and robust actuators.This review introduces the state of the art in the development of actuators that can be used in high speed active flow control.The classification and different operation criteria of the actuators are discussed.The specifications,mechanisms and applications of various popular actuator types including fluidic,mechanical,and plasma actuators are described.Based on the realistic need of high speed flow control and the existing results of actuators,a new actuator design method is proposed.At last,the merits and drawbacks of the actuators are summarized and some suggestions on the development of active flow control technology are put forward.

  11. High efficiency cell-specific targeting of cytokine activity

    Garcin, Geneviève; Paul, Franciane; Staufenbiel, Markus; Bordat, Yann; van der Heyden, José; Wilmes, Stephan; Cartron, Guillaume; Apparailly, Florence; de Koker, Stefaan; Piehler, Jacob; Tavernier, Jan; Uzé, Gilles

    2014-01-01

    Systemic toxicity currently prevents exploiting the huge potential of many cytokines for medical applications. Here we present a novel strategy to engineer immunocytokines with very high targeting efficacies. The method lies in the use of mutants of toxic cytokines that markedly reduce their receptor-binding affinities, and that are thus rendered essentially inactive. Upon fusion to nanobodies specifically binding to marker proteins, activity of these cytokines is selectively restored for cell populations expressing this marker. This ‘activity-by-targeting’ concept was validated for type I interferons and leptin. In the case of interferon, activity can be directed to target cells in vitro and to selected cell populations in mice, with up to 1,000-fold increased specific activity. This targeting strategy holds promise to revitalize the clinical potential of many cytokines.

  12. Business cycle and innovation activity in medium-high and high technology industry in Poland

    Dzikowski Piotr

    2015-12-01

    Full Text Available This article examines differences in an impact of business cycle phases on innovation activity in medium-high and high technology industry in Poland. It is assumed that each business cycle phase influences innovation activity in the same fashion, but its impact varies and it depends on the firm’s innovation activity. The higher innovation activity the less impact of business cycle. The scope of the survey relates to innovation in MHT and HT industry in Poland. The data concerns the innovation at the firm level and the diffusion “new for the company”. Innovation activity is defined by the following activities: (1 expenditure on research and development and investments in fixed assets not used so far such as: abuildings, premises and land; b machinery and equipment, c computer software; (2 implementation of new products and technological processes and (3 innovation cooperation. The methodological part of the analysis includes a logit modeling. The survey includes 1355 companies. Business cycle has a great influence on innovation activity in MTH and HT industry in Poland. The influence of recovery phase is positive whereas both stagnation and recession phases decrease the probability of innovation activity. The character of influence depends on the propensity to take innovation activity. The higher level of innovation activity the enterprises present the less influence of business cycle they get.

  13. 78 FR 70567 - Nationwide Use of High Frequency and Ultra High Frequency Active SONAR Technology; Final...

    2013-11-26

    ...] [FR Doc No: 2013-28337] DEPARTMENT OF HOMELAND SECURITY Coast Guard [Docket No. USCG-2009-0166... Programmatic Environmental Assessment (PEA) for the Nationwide Use of High Frequency (HF) and Ultra High..., recreational boating, or other maritime activities. The use of HF (50 to 999 kHz) and UHF (1,000 kHz and...

  14. Intake of Sweets, Snacks and Soft Drinks Predicts Weight Gain in Obese Pregnant Women

    Renault, Kristina M; Carlsen, Emma M; Nørgaard, Kirsten

    2015-01-01

    type of diet and physical activity intervention (D+PA); physical activity intervention alone (PA); or control (C). Diet was assessed at baseline (weeks 11-14) and endpoint (weeks 36-37) using a validated food frequency questionnaire. RESULTS: During the intervention women in the D+PA group...... for soft drinks were more conflicting, as women with high weight gain tended to favour artificially sweetened soft drinks. CONCLUSION: In our sample of obese pregnant women, craving for sweets, snacks, and soft drinks strongly predicts GWG. Emphasis on reducing intakes of these foods may be more relevant...... analyses revealed that foods that contributed to intake of added sugars, including sweets, snacks, cakes, and soft drinks were strongly associated with weight gain, with women consuming sweets ≥2/day having 5.4 kg (95% CI 2.1-8.7) greater weight gain than those with a low (

  15. A simple and highly effective process for the preparation of activated carbons with high surface area

    Li Ying, E-mail: liyingjlu@163.com [College of Chemistry, Jilin University, Changchun 130012 (China); Ding Xuefeng; Guo Yupeng; Wang Lili; Rong Chunguang; Qu Yuning; Ma Xiaoyu [College of Chemistry, Jilin University, Changchun 130012 (China); Wang Zichen, E-mail: wangzc@jlu.edu.cn [College of Chemistry, Jilin University, Changchun 130012 (China)

    2011-06-15

    Highlights: {yields} High surface area activated carbon can be prepared by rice husk H{sub 3}PO{sub 4} without pretreatment. {yields} The characteristics of the activated carbon were greatly influenced by post-processing method. {yields} The lower SiO{sub 2} content of the activated carbons, the higher pore volume the carbons had. {yields} Some silica in rice husk reacted with H{sub 3}PO{sub 4} to form SiP{sub 2}O{sub 7} which could be removed by post-process. - Abstract: Activated carbons with high surface area were prepared by phosphoric acid as activation agent and rice husks as precursors. It was found that the characteristics of the activated carbons were influenced not only by the preparation but also by the post-processing method. The high surface area of the activated carbons was prepared under the optimum condition (50% H{sub 3}PO{sub 4} with impregnation ratio of 5:1, activation temperature of 500 deg. C, activation time of 0.5 h, wash water temperature of 100 deg. C). SiO{sub 2} content could affect the surface area of activated carbons, either. The lower SiO{sub 2} content of the activated carbons, the higher pore volume the carbons had. The SiO{sub 2} content was 11.2% when used the optimum condition. The explanation was that silicon element in rice husks reacted with H{sub 3}PO{sub 4} to form silicon phosphate (SiP{sub 2}O{sub 7}), and it could be proved further by X-ray diffraction analysis, SiP{sub 2}O{sub 7} could be removed by post-process.

  16. Active Photonic crystal fibers for high power applications

    Olausson, Christina Bjarnal Thulin

    . This plays an important role in high power lasers and ampliers with respect to efficiency, packaging, and thermal handling. The third part of the work has involved developing tools for characterizing the mode quality and stability of large core bers. Stable, single-mode bers with larger cores are essential......The photonic crystal ber technology provides means to realize bers optimized for high power operation, due to the large single-mode cores and the unique design exibility of the microstructure. The work presented in this thesis focuses on improving the properties of active photonic crystal bers...... for high power ber lasers and ampliers, and on adding new functionality to the fibers - all with the purpose of pushing the technology towards high powers. The first part of the work has been to investigate photo darkening, the mitigation of which is crucial in the quest for higher powers. The work has...

  17. Development of high-lift laminar wing using steady active flow control

    Clayton, Patrick J.

    Fuel costs represent a large fraction of aircraft operating costs. Increased aircraft fuel efficiency is thus desirable. Laminar airfoils have the advantage of reduced cruise drag and increased fuel efficiency. Unfortunately, they cannot perform adequately during high-lift situations (i.e. takeoff and landing) due to low stall angles and low maximum lift caused by flow separation. Active flow control has shown the ability to prevent or mitigate separation effects, and increase maximum lift. This fact makes AFC technology a fitting solution for improving high-lift systems and reducing the need for slats and flap elements. This study focused on experimentally investigating the effects of steady active flow control from three slots, located at 1%, 10%, and 80% chord, respectively, over a laminar airfoil with 45 degree deflected flap. A 30-inch-span airfoil model was designed, fabricated, and then tested in the Bill James 2.5'x3' Wind Tunnel at Iowa State University. Pressure data were collected along the mid-span of the airfoil, and lift and drag were calculated. Five test cases with varying injection locations and varying Cμ were chosen: baseline, blown flap, leading edge blowing, equal blowing, and unequal blowing. Of these cases, unequal blowing achieved the greatest lift enhancement over the baseline. All cases were able to increase lift; however, gains were less than anticipated.

  18. High Resolution LC-MSn Fragmentation Pattern of Palytoxin as Template to Gain New Insights into Ovatoxin-a Structure. The Key Role of Calcium in MS Behavior of Palytoxins

    Ciminiello, Patrizia; Dell'Aversano, Carmela; Dello Iacovo, Emma; Fattorusso, Ernesto; Forino, Martino; Grauso, Laura; Tartaglione, Luciana

    2012-05-01

    Palytoxin is a potent marine toxin and one of the most complex natural compounds ever described. A number of compounds identified as palytoxin congeners (e.g., ovatoxins, mascarenotoxins, ostreocins, etc.) have not been yet structurally elucidated due to lack of pure material in quantities sufficient to an NMR-based structural investigation. In this study, the complex fragmentation pattern of palytoxin in its positive high resolution liquid chromatography tandem mass spectra (HR LC-MSn) was interpreted. Under the used conditions, the molecule underwent fragmentation at many sites of its backbone, and a large number of diagnostic fragment ions were identified. The natural product itself was used with no need for derivatization. Interestingly, most of the fragments contained calcium in their elemental formula. Evidence for palytoxin tendency to form adduct ions with calcium and other divalent cations in its mass spectra was obtained. Fragmentation pattern of palytoxin was used as template to gain detailed structural information on ovatoxin-a, the main toxin produced by Ostreopsis ovata, (observe correct font) a benthic dinoflagellate that currently represents the major harmful algal bloom threat in the Mediterranean area. Either the regions or the specific sites where ovatoxin-a and palytoxin structurally differ have been identified.

  19. Preclinical Study for Application of Fabricated High Activity Ir-192

    Chun, Mi Son; Kang, Seung Hee; Oh, Young Taek; Jeong, Chul; Kim, Mi Hwa; Hwang, Jeong Hye; Kim, Hee Seong; Im, Eun Jeong [Ajou University, Suwon (Korea, Republic of)

    2005-10-15

    This study was performed to evaluate the feasibility and safety of high activity Ir-192 sources manufactured by KAERI(Korea Atomic Energy Research Institute) for application to present equipment such as various applicators inserted to patients and PLATO(Nucletron, Netherland) of treatment planning system and to evaluate safety and accuracy of Ir-192 as practical clinic use through in vitro dosimetry of Ir-192. We confirmed the physical and radiobiological safety of KAERI sources to use practical. KAERI sources are applicable to commercial high dose rate brachytherapy machine safely. Then those can be substituted for the imported sources such as sources made by Nucletron, Gammamed and exported to the foreign country

  20. A CMOS Wideband Linear Current Attenuator with Electronically Variable Gain

    Wiegerink, Remco J.

    1993-01-01

    A CMOS highly linear current attenuator is described. The circuit is suited for both differential and single input currents. The current gain is electronically variable between -1 and +1 by means of two controlling currents. A simple additional circuit is described to obtain a gain that is linearly

  1. Activated blended cement containing high volume coal fly ash

    Shi, C.J.; Qian, J.S. [CJS Technology Inc., Burlington, ON (Canada)

    2001-10-01

    This study investigated the strength and equilibrium water extraction of blended cement containing high volume coal fly ash and activator CaCl{sub 2}. The addition of CaCl{sub 2} increased the strength of cement very significantly. Equilibrium water extraction indicated that the addition of CaCl{sub 2} decreased the pH of the pore solution, but accelerated the pozzolanic reactions between coal fly ash and lime, which became more obvious when the volume of fly ash in the cement was increased from 50-70%. Results from both strength and water extraction testing could conclude that CaCl{sub 2} is a good activator for the activation of pozzolanic reactivity of fly ash and for the improvement of early properties of fly ash cement and concrete.

  2. The design of wideband high gain co-caliber dual circular polarization-agile antenna%宽频带高增益共口径双圆极化捷变天线设计

    马世娟; 王建; 司海峰

    2016-01-01

    In order to improve the performances of low probability of intercept (LPI) radar systems, for meeting the needs of LPI equipment to the transmit antenna, a wide bandwidth, high gain, total diameter dual circularly polarized antenna is designed in this paper., the polarization agility can be realized by controlling the port feed method. The design antenna can be achieved with a beam scanning and multi-beam function by changing frequency. Waveguide slot unit structure, line array composed by 19 units and plane array composed by 12 line arrays are designed. The use of Teflon with dielectric constant of 2.3 is filling into the waveguide cavity to suppress grating lobes. According to the particularity of the antenna structure, a waveguide and coaxial adapter is designed to feed. The overall optimization of antenna simulation results show that, the gain of line array is 19 dB and the average gain of plane array is 30 dB. The VSWR is below 1.1 at the absolute bandwidth of 3.75 GHz, and the relative bandwidth is up to 13.5% . The designed antenna simplifies the structure of the polarization agility antenna, reduces the antenna size, which meets the needs of LPI radar transmitting antenna.%为了提高低截获概率雷达系统的性能,针对低截获概率设备对发射天线的需求,文中设计了一种宽频带、高增益、共口径双圆极化天线,通过控制端口馈电方式实现左右旋圆极化捷变.同时,该天线可通过频率变化实现波束扫描与多波束功能.设计了波导缝隙单元结构、19单元线阵及19×12面阵.为了抑制栅瓣的产生,利用介电常数为2.3的聚四氟乙烯部分填充于波导腔中.根据天线结构的特殊性设计了波导/同轴转接器.天线整体仿真优化结果表明,线阵增益为19 dB,面阵平均增益为30 dB.在绝对带宽3.75 GHz范围内该面阵天线的驻波比小于1.1,轴比小于3 dB,相对带宽可达13.5%.从而简化了极化捷变天线的结构,减小了天线体积,满

  3. Accelerator Production and Separations for High Specific Activity Rhenium-186

    Jurisson, Silvia S. [Univ. of Missouri, Columbia, MO (United States); Wilbur, D. Scott [Univ. of Washington, Seattle, WA (United States)

    2016-04-01

    Tungsten and osmium targets were evaluated for the production of high specific activity rhenium-186. Rhenium-186 has potential applications in radiotherapy for the treatment of a variety of diseases, including targeting with monoclonal antibodies and peptides. Methods were evaluated using tungsten metal, tungsten dioxide, tungsten disulfide and osmium disulfide. Separation of the rhenium-186 produced and recycling of the enriched tungsten-186 and osmium-189 enriched targets were developed.

  4. Mining Chemical Activity Status from High-Throughput Screening Assays

    Soufan, Othman

    2015-12-14

    High-throughput screening (HTS) experiments provide a valuable resource that reports biological activity of numerous chemical compounds relative to their molecular targets. Building computational models that accurately predict such activity status (active vs. inactive) in specific assays is a challenging task given the large volume of data and frequently small proportion of active compounds relative to the inactive ones. We developed a method, DRAMOTE, to predict activity status of chemical compounds in HTP activity assays. For a class of HTP assays, our method achieves considerably better results than the current state-of-the-art-solutions. We achieved this by modification of a minority oversampling technique. To demonstrate that DRAMOTE is performing better than the other methods, we performed a comprehensive comparison analysis with several other methods and evaluated them on data from 11 PubChem assays through 1,350 experiments that involved approximately 500,000 interactions between chemicals and their target proteins. As an example of potential use, we applied DRAMOTE to develop robust models for predicting FDA approved drugs that have high probability to interact with the thyroid stimulating hormone receptor (TSHR) in humans. Our findings are further partially and indirectly supported by 3D docking results and literature information. The results based on approximately 500,000 interactions suggest that DRAMOTE has performed the best and that it can be used for developing robust virtual screening models. The datasets and implementation of all solutions are available as a MATLAB toolbox online at www.cbrc.kaust.edu.sa/dramote and can be found on Figshare.

  5. Mining Chemical Activity Status from High-Throughput Screening Assays.

    Soufan, Othman; Ba-alawi, Wail; Afeef, Moataz; Essack, Magbubah; Rodionov, Valentin; Kalnis, Panos; Bajic, Vladimir B

    2015-01-01

    High-throughput screening (HTS) experiments provide a valuable resource that reports biological activity of numerous chemical compounds relative to their molecular targets. Building computational models that accurately predict such activity status (active vs. inactive) in specific assays is a challenging task given the large volume of data and frequently small proportion of active compounds relative to the inactive ones. We developed a method, DRAMOTE, to predict activity status of chemical compounds in HTP activity assays. For a class of HTP assays, our method achieves considerably better results than the current state-of-the-art-solutions. We achieved this by modification of a minority oversampling technique. To demonstrate that DRAMOTE is performing better than the other methods, we performed a comprehensive comparison analysis with several other methods and evaluated them on data from 11 PubChem assays through 1,350 experiments that involved approximately 500,000 interactions between chemicals and their target proteins. As an example of potential use, we applied DRAMOTE to develop robust models for predicting FDA approved drugs that have high probability to interact with the thyroid stimulating hormone receptor (TSHR) in humans. Our findings are further partially and indirectly supported by 3D docking results and literature information. The results based on approximately 500,000 interactions suggest that DRAMOTE has performed the best and that it can be used for developing robust virtual screening models. The datasets and implementation of all solutions are available as a MATLAB toolbox online at www.cbrc.kaust.edu.sa/dramote and can be found on Figshare.

  6. Gestational Weight Gain: Results from the Delta Healthy Sprouts Comparative Impact Trial

    Olender, Sarah E.

    2016-01-01

    Introduction. Delta Healthy Sprouts trial was designed to test the comparative impact of two home visiting programs on weight status, dietary intake, and health behaviors of Southern African American women and their infants. Results pertaining to the primary outcome, gestational weight gain, are reported. Methods. Participants (n = 82), enrolled early in their second trimester of pregnancy, were randomly assigned to one of two treatment arms. Gestational weight gain, measured at six monthly home visits, was calculated by subtracting measured weight at each visit from self-reported prepregnancy weight. Weight gain was classified as under, within, or exceeding the Institute of Medicine recommendations based on prepregnancy body mass index. Chi-square tests and generalized linear mixed models were used to test for significant differences in percentages of participants within recommended weight gain ranges. Results. Differences in percentages of participants within the gestational weight gain guidelines were not significant between treatment arms across all visits. Conclusions. Enhancing the gestational nutrition and physical activity components of an existing home visiting program is feasible in a high risk population of primarily low income African American women. The impact of these enhancements on appropriate gestational weight gain is questionable given the more basic living needs of such women. This trial is registered with ClinicalTrials.gov NCT01746394, registered 4 December 2012. PMID:27595023

  7. Gestational Weight Gain: Results from the Delta Healthy Sprouts Comparative Impact Trial

    Jessica L. Thomson

    2016-01-01

    Full Text Available Introduction. Delta Healthy Sprouts trial was designed to test the comparative impact of two home visiting programs on weight status, dietary intake, and health behaviors of Southern African American women and their infants. Results pertaining to the primary outcome, gestational weight gain, are reported. Methods. Participants (n=82, enrolled early in their second trimester of pregnancy, were randomly assigned to one of two treatment arms. Gestational weight gain, measured at six monthly home visits, was calculated by subtracting measured weight at each visit from self-reported prepregnancy weight. Weight gain was classified as under, within, or exceeding the Institute of Medicine recommendations based on prepregnancy body mass index. Chi-square tests and generalized linear mixed models were used to test for significant differences in percentages of participants within recommended weight gain ranges. Results. Differences in percentages of participants within the gestational weight gain guidelines were not significant between treatment arms across all visits. Conclusions. Enhancing the gestational nutrition and physical activity components of an existing home visiting program is feasible in a high risk population of primarily low income African American women. The impact of these enhancements on appropriate gestational weight gain is questionable given the more basic living needs of such women. This trial is registered with ClinicalTrials.gov NCT01746394, registered 4 December 2012.

  8. High Electrocatalytic Hydrogen Evolution Activity of an Anomalous Ruthenium Catalyst

    Zheng, Yao

    2016-11-28

    Hydrogen evolution reaction (HER) is a critical process due to its fundamental role in electrocatalysis. Practically, the development of high-performance electrocatalysts for HER in alkaline media is of great importance for the conversion of renewable energy to hydrogen fuel via photoelectrochemical water splitting. However, both mechanistic exploration and materials development for HER under alkaline conditions are very limited. Precious Pt metal, which still serves as the state-of-the-art catalyst for HER, is unable to guarantee a sustainable hydrogen supply. Here we report an anomalously structured Ru catalyst that shows 2.5 times higher hydrogen generation rate than Pt and is among the most active HER electrocatalysts yet reported in alkaline solutions. The identification of new face-centered cubic crystallographic structure of Ru nanoparticles was investigated by high-resolution transmission electron microscopy imaging, and its formation mechanism was revealed by spectroscopic characterization and theoretical analysis. For the first time, it is found that the Ru nanocatalyst showed a pronounced effect of the crystal structure on the electrocatalytic activity tested under different conditions. The combination of electrochemical reaction rate measurements and density functional theory computation shows that the high activity of anomalous Ru catalyst in alkaline solution originates from its suitable adsorption energies to some key reaction intermediates and reaction kinetics in the HER process.

  9. Gain measurements on the sequence bands in a TEA-CO/sub 2/ amplifier

    Lavigne, P.; Lachambre, J.L.; Otis, G.

    1978-04-01

    After having measured small-signal gains as high as 1.5% cm-1 in a TEA CO/sub 2/ amplifier on the 00 2-(10 1, 02 1) sequence bands, the authors have concluded that the ratio of the gain coefficient of the sequence bands over that of the regular bands was independent of either the CO/sub 2/ or He proportion in the gas mixture. This ratio rather increases with the electrical energy dumped into the active medium to reach a value of 1/3 at an excitation density of 140 J/lambda. Due to the relatively high gain of the sequence bands, it should be possible to have standard TEA CO/sub 2/ lasers emit at frequencies where the atmospheric transmission at sea level is higher than at the regular emission frequencies. Furthermore, gain on the sequence bands was responsible for the anomalously high-gain coefficient measured at low J values of the R branch of the regular 9.4-micrometer transition in TEA amplifiers.

  10. Pregnancy weight gain and breast cancer risk

    Hemminki Elina

    2004-10-01

    Full Text Available Abstract Background Elevated pregnancy estrogen levels are associated with increased risk of developing breast cancer in mothers. We studied whether pregnancy weight gain that has been linked to high circulating estrogen levels, affects a mother's breast cancer risk. Methods Our cohort consisted of women who were pregnant between 1954–1963 in Helsinki, Finland, 2,089 of which were eligible for the study. Pregnancy data were collected from patient records of maternity centers. 123 subsequent breast cancer cases were identified through a record linkage to the Finnish Cancer Registry, and the mean age at diagnosis was 56 years (range 35 – 74. A sample of 979 women (123 cases, 856 controls from the cohort was linked to the Hospital Inpatient Registry to obtain information on the women's stay in hospitals. Results Mothers in the upper tertile of pregnancy weight gain (>15 kg had a 1.62-fold (95% CI 1.03–2.53 higher breast cancer risk than mothers who gained the recommended amount (the middle tertile, mean: 12.9 kg, range 11–15 kg, after adjusting for mother's age at menarche, age at first birth, age at index pregnancy, parity at the index birth, and body mass index (BMI before the index pregnancy. In a separate nested case-control study (n = 65 cases and 431 controls, adjustment for BMI at the time of breast cancer diagnosis did not modify the findings. Conclusions Our study suggests that high pregnancy weight gain increases later breast cancer risk, independently from body weight at the time of diagnosis.

  11. AHEAD: Integrated Activities in the High Energy Astrophysics Domain

    Piro, Luigi; Natalucci, Lorenzo; Ahead Consortium

    2015-09-01

    AHEAD (Integrated Activities in the High Energy Astrophysics Domain) is a forthcoming project approved in the framework of the European Horizon 2020 program (Research Infrastructures for High Energy Astrophysics). The overall objective of AHEAD is to integrate national efforts in high-energy Astrophysics and to promote the domain at the European level, to keep its community at the cutting edge of science and technology and ensure that space observatories for high-energy astrophysics, with particular regard to Athena, are at the state of the art. AHEAD will integrate key research infrastructures for on-ground test and calibration of space-based sensors and electronics and promote their coordinated use. In parallel, the best facilities for data analysis of high-energy astrophysical observatories will be made available to the European community. The technological development will focus on the improvement of selected critical technologies, background modeling, cross calibration, and feasibility studies of space-based instrumentation for the benefit of future high energy missions like Athena, and the best exploitation of existing observatories. AHEAD will support the community via grants for collaborative studies, dissemination of results, and promotion of workshops. A strong public outreach package will ensure that the domain is well publicized at national, European and International level. Networking, joint research activities and access to infrastructures as devised in AHEAD, will serve to establish strong connections between institutes and industry to create the basis for a more rapid advancement of high-energy astrophysical science, space oriented instrumentation and cutting-edge sensor technology in Europe. This enables the development of new technologies and the associated growth of the European technology market with a dedicated technology innovation package, as well as the creation of a new generation of researchers.

  12. Large Optical Gain AlInN-Delta-GaN Quantum Well for Deep Ultraviolet Emitters.

    Tan, Chee-Keong; Sun, Wei; Borovac, Damir; Tansu, Nelson

    2016-01-01

    The optical gain and spontaneous emission characteristics of low In-content AlInN-delta-GaN quantum wells (QWs) are analyzed for deep ultraviolet (UV) light emitting diodes (LEDs) and lasers. Our analysis shows a large increase in the dominant transverse electric (TE) polarized spontaneous emission rate and optical gain. The remarkable enhancements in TE-polarized optical gain and spontaneous emission characteristics are attributed to the dominant conduction (C)-heavy hole (HH) transitions achieved by the AlInN-delta-GaN QW structure, which could lead to its potential application as the active region material for high performance deep UV emitters. In addition, our findings show that further optimizations of the delta-GaN layer in the active region are required to realize the high performance AlInN-based LEDs and lasers with the desired emission wavelength. This work illuminates the high potential of the low In-content AlInN-delta-GaN QW structure to achieve large dominant TE-polarized spontaneous emission rates and optical gains for high performance AlN-based UV devices.

  13. Design of the GaN power amplifier for high gain and ultra-wideband%高增益宽频带GaN功率放大器设计

    张佳浩

    2016-01-01

    针对新一代半导体材料氮化镓(Gallium Nitride,GaN)带宽大、效率高的优点,利用ADS谐波平衡仿真软件,设计了一个1.5~2.5GHz宽带高效的功率放大器。设计采用Cree公司的GaN 高电子迁移率晶体管CGH40010F,利用晶体管的大信号模型进行电路仿真,结果显示,功放在1.5~2.5GHz频带内,饱和输出功率大于41.7dBm,小信号增益大于18dB,功率附加效率大于70%。%This letter designs a 1.5~2.5GHz broadband highly efficient PA using the ADS harmonic-balanced simulator based on GaN,a new semiconductor materials with wide bandwidth and high efficience.The PA was designed with Cree’s GaN HEMT CGH40010F,and simulated with its large signal model.The result shows that the PA had a saturated power above 41.7dBm,a small signal gain over 18dB and the PAE above 74% in 1.5~2.5GHz frequency band.

  14. Highly porous activated carbons prepared from carbon rich Mongolian anthracite by direct NaOH activation

    Byamba-Ochir, Narandalai; Shim, Wang Geun; Balathanigaimani, M. S.; Moon, Hee

    2016-08-01

    Highly porous activated carbons (ACs) were prepared from Mongolian raw anthracite (MRA) using sodium hydroxide as an activation agent by varying the mass ratio (powdered MRA/NaOH) as well as the mixing method of chemical agent and powdered MRA. The specific BET surface area and total pore volume of the prepared MRA-based activated carbons (MACs) are in the range of 816-2063 m2/g and of 0.55-1.61 cm3/g, respectively. The pore size distribution of MACs show that most of the pores are in the range from large micropores to small mesopores and their distribution can be controlled by the mass ratio and mixing method of the activating agent. As expected from the intrinsic property of the MRA, the highly graphitic surface morphology of prepared carbons was confirmed from Raman spectra and transmission electron microscopy (TEM) studies. Furthermore the FTIR and XPS results reveal that the preparation of MACs with hydrophobic in nature is highly possible by controlling the mixing conditions of activating agent and powdered MRA. Based on all the results, it is suggested that the prepared MACs could be used for many specific applications, requiring high surface area, optimal pore size distribution, proper surface hydrophobicity as well as strong physical strength.

  15. Microbial fuel cells with highly active aerobic biocathodes

    Milner, Edward M.; Popescu, Dorin; Curtis, Tom; Head, Ian M.; Scott, Keith; Yu, Eileen H.

    2016-08-01

    Microbial fuel cells (MFCs), which convert organic waste to electricity, could be used to make the wastewater infrastructure more energy efficient and sustainable. However, platinum and other non-platinum chemical catalysts used for the oxygen reduction reaction (ORR) at the cathode of MFCs are unsustainable due to their high cost and long-term degradation. Aerobic biocathodes, which use microorganisms as the biocatalysts for cathode ORR, are a good alternative to chemical catalysts. In the current work, high-performing aerobic biocathodes with an onset potential for the ORR of +0.4 V vs. Ag/AgCl were enriched from activated sludge in electrochemical half-cells poised at -0.1 and + 0.2 V vs. Ag/AgCl. Gammaproteobacteria, distantly related to any known cultivated gammaproteobacterial lineage, were identified as dominant in these working electrode biofilms (23.3-44.3% of reads in 16S rRNA gene Ion Torrent libraries), and were in very low abundance in non-polarised control working electrode biofilms (0.5-0.7%). These Gammaproteobacteria were therefore most likely responsible for the high activity of biologically catalysed ORR. In MFC tests, a high-performing aerobic biocathode increased peak power 9-fold from 7 to 62 μW cm-2 in comparison to an unmodified carbon cathode, which was similar to peak power with a platinum-doped cathode at 70 μW cm-2.

  16. High Sulfation and a High Molecular Weight Are Important for Anti-hepcidin Activity of Heparin

    Asperti, Michela; Naggi, Annamaria; Esposito, Emiliano; Ruzzenenti, Paola; Di Somma, Margherita; Gryzik, Magdalena; Arosio, Paolo; Poli, Maura

    2016-01-01

    Heparins are efficient inhibitors of hepcidin expression even in vivo, where they induce an increase of systemic iron availability. Heparins seem to act by interfering with BMP6 signaling pathways that control the expression of liver hepcidin, causing the suppression of SMAD1/5/8 phosphorylation. The anti-hepcidin activity persists also when the heparin anticoagulant property is abolished or reduced by chemical reactions of oxidation/reduction (glycol-split, Gs-Heparins) or by high sulfation (SS-Heparins), but the structural characteristics needed to optimize this inhibitory activity have not been studied in detail. To this aim we analyzed three different heparins (Mucosal Heparin, the Glycol split RO-82, the partially desulfated glycol-split RO-68 and the oversulfated SSLMWH) and separated them in fractions of molecular weight in the range 4–16 kD. Since the distribution of the negative charges in heparins contributes to the activity, we produced 2-O- and 6-O-desulfated heparins. These derivatives were analyzed for the capacity to inhibit hepcidin expression in hepatic HepG2 cells and in mice. The two approaches produced consistent results and showed that the anti-hepcidin activity strongly decreases with molecular weight below 7 kD, with high N-acetylation and after 2-O and 6-O desulfation. The high sulfation and high molecular weight properties for efficient anti-hepcidin activity suggest that heparin is involved in multiple binding sites. PMID:26955355

  17. Active Change in Psychodynamic Therapy: Moments of High Receptiveness.

    De Gauna, Mariano De Iceta Ibáñez; Roibal, M Angela Soler; Ruiz, José Antonio Méndez; Fernández, Joaquin Ingelmo; Bleichmar, Hugo B

    2015-01-01

    This article presents the concept of "moments of high receptiveness" (MoHR or "Momentos de Alta Receptividad"), which is derived from the concept of "experiential coupling" ("Acoplamiento de Experiencias") proposed by Bleichmar (2001). Experiential coupling recently received empirical support by the work of Schiller and colleagues (2010). We will also show the conceptual placing of moments of high receptiveness with respect to the developments of Stern and colleagues (Stern and et al., 1998; Stern, 2004). In order to achieve both objectives, we focus on various clinical vignettes stressing the differences in repercussions of the technique. We describe use of stimuli for active evocation, explain how to identify moments of high receptiveness, and review ways to take advantage of these moments. Lastly, to minimize the risk of iatrogenic symptoms, we examine the role of therapists and some features of the therapeutic process when using this technique.

  18. Telomerase activation by genomic rearrangements in high-risk neuroblastoma.

    Peifer, Martin; Hertwig, Falk; Roels, Frederik; Dreidax, Daniel; Gartlgruber, Moritz; Menon, Roopika; Krämer, Andrea; Roncaioli, Justin L; Sand, Frederik; Heuckmann, Johannes M; Ikram, Fakhera; Schmidt, Rene; Ackermann, Sandra; Engesser, Anne; Kahlert, Yvonne; Vogel, Wenzel; Altmüller, Janine; Nürnberg, Peter; Thierry-Mieg, Jean; Thierry-Mieg, Danielle; Mariappan, Aruljothi; Heynck, Stefanie; Mariotti, Erika; Henrich, Kai-Oliver; Gloeckner, Christian; Bosco, Graziella; Leuschner, Ivo; Schweiger, Michal R; Savelyeva, Larissa; Watkins, Simon C; Shao, Chunxuan; Bell, Emma; Höfer, Thomas; Achter, Viktor; Lang, Ulrich; Theissen, Jessica; Volland, Ruth; Saadati, Maral; Eggert, Angelika; de Wilde, Bram; Berthold, Frank; Peng, Zhiyu; Zhao, Chen; Shi, Leming; Ortmann, Monika; Büttner, Reinhard; Perner, Sven; Hero, Barbara; Schramm, Alexander; Schulte, Johannes H; Herrmann, Carl; O'Sullivan, Roderick J; Westermann, Frank; Thomas, Roman K; Fischer, Matthias

    2015-10-29

    Neuroblastoma is a malignant paediatric tumour of the sympathetic nervous system. Roughly half of these tumours regress spontaneously or are cured by limited therapy. By contrast, high-risk neuroblastomas have an unfavourable clinical course despite intensive multimodal treatment, and their molecular basis has remained largely elusive. Here we have performed whole-genome sequencing of 56 neuroblastomas (high-risk, n = 39; low-risk, n = 17) and discovered recurrent genomic rearrangements affecting a chromosomal region at 5p15.33 proximal of the telomerase reverse transcriptase gene (TERT). These rearrangements occurred only in high-risk neuroblastomas (12/39, 31%) in a mutually exclusive fashion with MYCN amplifications and ATRX mutations, which are known genetic events in this tumour type. In an extended case series (n = 217), TERT rearrangements defined a subgroup of high-risk tumours with particularly poor outcome. Despite a large structural diversity of these rearrangements, they all induced massive transcriptional upregulation of TERT. In the remaining high-risk tumours, TERT expression was also elevated in MYCN-amplified tumours, whereas alternative lengthening of telomeres was present in neuroblastomas without TERT or MYCN alterations, suggesting that telomere lengthening represents a central mechanism defining this subtype. The 5p15.33 rearrangements juxtapose the TERT coding sequence to strong enhancer elements, resulting in massive chromatin remodelling and DNA methylation of the affected region. Supporting a functional role of TERT, neuroblastoma cell lines bearing rearrangements or amplified MYCN exhibited both upregulated TERT expression and enzymatic telomerase activity. In summary, our findings show that remodelling of the genomic context abrogates transcriptional silencing of TERT in high-risk neuroblastoma and places telomerase activation in the centre of transformation in a large fraction of these tumours.

  19. High Performance Activity Practices in Small Firms in Romania

    Gabriela ŢUŢUEANU

    2014-12-01

    Full Text Available High Performance Activity Practices in Small Firms in Romania Abstract: High performance activity practices (HPAPs are human resource management activities aimed at stimulating employee and organisational performance. The application of HPAPs is not widespread in small organisations. We examine whether the implementation of coherent bundles of HPAPs (aimed at employee ability, employee motivation or at the opportunity to perform depends on the scarcity of resources, as reflected in the size of the company, and on strategic decision-making in small firms related to the owner’s expertise and attitudes. In our research, a total of 224 employees from 50 small organisations were asked to rate the presence of HPAPs in their organisation. These averaged perceptions were linked to information provided by the owner–managers on the size of their firm and their own expertise and attitudes. The findings support that smaller but coherent bundles of HPAPs can be found in small organisations and that the implementation of these bundles depends on available resources, strategic decision-making and the combination of the two. These findings highlight the need to integrate the notions of resource poverty and strategic decision-making to understand the uptake of bundles of HPAPs within small firms.

  20. Raman gains of ADP and KDP crystals

    周海亮; 柴向旭; 张清华; 王波; 许心光; 王正平; 孙洵; 张芳; 张立松; 刘宝

    2015-01-01

    In this paper, the Raman gain coefficients of ammonium dihydrogen phosphate (ADP) and potassium dihydrogen phosphate (KDP) crystals are measured. By using a pump source of a 30-ps, 532-nm laser, the gain coefficients of ADP and KDP are 1.22 cm/GW, and 0.91 cm/GW, respectively. While for a 20-ps, 355-nm pump laser, the gain coefficients of these two crystals are similar, which are 1.95 cm/GW for ADP and 1.86 for KDP. The present results indicate that for ultra-violet frequency conversion, the problem of stimulated Raman scattering for ADP crystal will not be more serious than that for KDP crystal. Considering other advantages such the larger nonlinear optical coefficient, higher laser damage threshold, and lower noncritical phase-matching temperature, it can be anticipated that ADP will be a powerful competitor to KDP in large aperture, high energy third-harmonic generation or fourth-harmonic generation applications.

  1. Commutated automatic gain control system

    Yost, S. R.

    1982-01-01

    The commutated automatic gain control (AGC) system was designed and built for the prototype Loran-C receiver is discussed. The current version of the prototype receiver, the Mini L-80, was tested initially in 1980. The receiver uses a super jolt microcomputer to control a memory aided phase loop (MAPLL). The microcomputer also controls the input/output, latitude/longitude conversion, and the recently added AGC system. The AGC control adjusts the level of each station signal, such that the early portion of each envelope rise is about at the same amplitude in the receiver envelope detector.

  2. Highly Active Rare-Earth-Metal La-Doped Photocatalysts: Fabrication, Characterization, and Their Photocatalytic Activity

    S. Anandan

    2012-01-01

    Full Text Available Efficient La-doped TiO2 photocatalysts were prepared by sol-gel method and extensively characterized by various sophisticated techniques. The photocatalytic activity of La-doped TiO2 was evaluated for the degradation of monocrotophos (MCPs in aqueous solution. It showed higher rate of degradation than pure TiO2 for the light of wavelength of 254 nm and 365 nm. The rate constant of TiO2 increases with increasing La loading and exhibits maximum rate for 1% La loading. The photocatalytic activities of La-doped TiO2 are compared with La-doped ZnO; the reaction rate of the former is ~1.8 and 1.1 orders higher than the latter for the lights of wavelength 254 nm and 365 nm, respectively. The relative photonic efficiency of La-doped TiO2 is relatively higher than La-doped ZnO and commercial photocatalysts. Overall, La-doped TiO2 is the most active photocatalyst and shows high relative photonic efficiencies and high photocatalytic activity for the degradation of MCP. The enhanced photocatalytic activity of La-doped TiO2 is mainly due to the electron trapping by lanthanum metal ions, small particle size, large surface area, and high surface roughness of the photocatalysts.

  3. Use of dominant harmonic active filters in high power applications

    Cheng, Po-Tai

    The application of power electronics equipment is increasing rapidly. It is estimated that 60% of electrical power will be processed by power electronics equipment by year 2000. These equipments typically require rectifiers for AC-DC power conversion. Due to their nonlinear nature, most rectifiers draw harmonic current from the utility grid. The harmonic current causes higher energy losses, and may excite resonance conditions in the utility grid. Harmonic standards such as IEEE 519 and IEC 1000-3-2 have been proposed to regulate the harmonic current and voltage levels. This work is to develop a dominant harmonic active filter (DHAF) to realize a cost-effective active filtering solution for nonlinear loads in the range of megawatt and above. The DHAF system achieves harmonic isolation at dominant harmonic frequencies, e.g. the 5th and 7th. This approach allows use of low switching frequency and small rating active filter inverters (1%--2% of the load MVA rating) for implementation. Review of conventional passive filters and various active filters based on high bandwidth PWM inverters is provided. The control theory of the DHAF system is presented. Comparison of the DHAF system and other dominant harmonic filtering approach is provided. Simulation results and laboratory prototype test results are presented to validate the effectiveness of the proposed DHAF system.

  4. 基于高阶高增益滑模观测器的混沌同步研究%Higher-order High-gain Sliding Mode Observer Based on Chaos Synchronization

    张良; 朱芳来

    2013-01-01

    基于驱动响应结构,针对一类混沌系统,提出了一种高阶高增益响应系统的设计方法.基于增维的思想,所提出的响应系统不仅能估计出系统的状态,还能估计出状态的微分.基于混沌同步,考虑了该类混沌系统的基于混沌同步的保密机制,在发射器和接受器达到同步的前提下,提出了一种新的信号还原的方法.该方法没有用到系统的微分信息,同时对强时变信号可以还原.针对一个SQCF混沌系统进行仿真实验,结果表明了方法的有效性.%Within the drive-response configuration, this paper develops a higher-order high-gain sliding mode observer used as response system for a class of chaotic system. By the technique of augmenting the dimension of original system, the proposed response system is able to estimate not only the drive system' s states themselves but also their derivatives. Based on chaotic synchronization, the chaos-based secure communication mechanism is considered. A new signal recovery method is proposed after the receiver has been synchronized by the transmitter. Our method is able to recover strong-time-varying signals without using any differential information of the drive system. The SQCF chaotic system is considered as an illustrative example to demonstrate the effectiveness of the proposed approaches.

  5. Easy and Rapid Purification of Highly Active Nisin

    André Abts

    2011-01-01

    Full Text Available Nisin is an antimicrobial peptide produced and secreted by several L. lactis strains and is specifically active against Gram-positive bacteria. In previous studies, nisin was purified via cation exchange chromatography at low pH employing a single-step elution using 1 M NaCl. Here, we describe an optimized purification protocol using a five-step NaCl elution to remove contaminants. The obtained nisin is devoid of impurities and shows high bactericidal activity against the nisin-sensitive L. lactis strain NZ9000. Purified nisin exhibits an IC50 of ~3 nM, which is a tenfold improvement as compared to nisin obtained via the one-step elution procedure.

  6. Sulfurized activated carbon for high energy density supercapacitors

    Huang, Yunxia; Candelaria, Stephanie L.; Li, Yanwei; Li, Zhimin; Tian, Jianjun; Zhang, Lili; Cao, Guozhong

    2014-04-01

    Sulfurized activated carbon (SAC), made by coating the pore surface with thiophenic sulfur functional groups from the pyrolysis of sulfur flakes, were characterized and tested for supercapacitor applications. From X-ray photoelectron spectroscopy (XPS), the sulfur content in the SAC was found to be 2.7 at%. Electrochemical properties from potentiostatic and galvanostatic measurements, and electrochemical impedance spectroscopy (EIS) were used to evaluate the effect of sulfur on porous carbon electrodes. The SAC electrode exhibits better conductivity, and an obvious increase in specific capacitance that is almost 40% higher than plain activated carbons (ACs) electrode at a high current density of 1.4 A g-1. The proposed mechanism for improved conductivity and capacitive performance due to the sulfur functional groups on ACs will be discussed.

  7. Information Gains from Cosmological Probes

    Grandis, S; Refregier, A; Amara, A; Nicola, A

    2015-01-01

    In light of the growing number of cosmological observations, it is important to develop versatile tools to quantify the constraining power and consistency of cosmological probes. Originally motivated from information theory, we use the relative entropy to compute the information gained by Bayesian updates in units of bits. This measure quantifies both the improvement in precision and the 'surprise', i.e. the tension arising from shifts in central values. Our starting point is a WMAP9 prior which we update with observations of the distance ladder, supernovae (SNe), baryon acoustic oscillations (BAO), and weak lensing as well as the 2015 Planck release. We consider the parameters of the flat $\\Lambda$CDM concordance model and some of its extensions which include curvature and Dark Energy equation of state parameter $w$. We find that, relative to WMAP9 and within these model spaces, the probes that have provided the greatest gains are Planck (10 bits), followed by BAO surveys (5.1 bits) and SNe experiments (3.1 ...

  8. Production of N-13 labeled compounds with high specific activity

    Suzuki, Kazutoshi; Sasaki, Motoji; Yoshida, Yuichiro; Haradahira, Terushi; Inoue, Osamu [National Inst. of Radiological Sciences, Chiba (Japan)

    1997-03-01

    Nitrogen-13 was produced by irradiating ultra pure water saturated with a pure gas (N2, O2, He, H2) with 18 MeV protons. Ion species generated by irradiation were analyzed with radio ion chromatography systems. An automated equipment was developed to synthesize anhydrous (13N)NH3 as a synthetic precursor and (13N)p-nitrophenyl carbamate ((13N)NPC) as a model compound, using the (13N)NH3. The radiochemical yield and specific activity of (13N)NPC was high enough to carry out the receptor study with PET. (author)

  9. Magneto-Optical Activity in High Index Dielectric Nanoantennas

    de Sousa, N; Sáenz, J J; García-Martín, A

    2016-01-01

    The magneto-optical activity, namely the polarization conversion capabilities of high-index, non-absorbing, core-shell dielectric nanospheres is theoretically analyzed. We show that, in analogy with their plasmonic counterparts, the polarization conversion in resonant dielectric particles is linked to the amount of electromagnetic field probing the magneto-optical material in the system. However, in strong contrast with plasmon nanoparticles, due to the peculiar distribution of the internal fields in resonant dielectric spheres, the magneto-optical response is fully governed by the magnetic (dipolar and quadrupolar) resonances with little effect of the electric ones.

  10. Highly Active Carbene Ruthenium Catalyst for Metathesis of 1-Hexene

    BAI Chen-Xi; ZHANG Zhi-Qiang; L(U) Xiao-Bing; HE Ren; ZHANG Wen-Zhen; LU Shu-Lai

    2006-01-01

    A new carbene ruthenium complex, 1,3-bis(2,6-dimethylphenyl)-4,5-dihydroimidazol-2-ylidene)(PPh3)Cl2-Ru=CHPh, was synthesized and used as catalyst for the metathesis of 1-hexene. The resulting complex exhibited very high catalytic activity whose TOF is up to 6680 h-1. However, at the same time significant olefin isomerization was observed and could be surpressed by changing reaction conditions, such as temperature, time, alkene/Ru molar ratio and solvent.

  11. Nordihydroguaiaretic acid protects against high-fat diet-induced fatty liver by activating AMP-activated protein kinase in obese mice

    Lee, Myoung-Su; Kim, Daeyoung; Jo, Keunae [Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 262 Seongsanno, Seodaemun-gu, Seoul 120-749 (Korea, Republic of); Hwang, Jae-Kwan, E-mail: jkhwang@yonsei.ac.kr [Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 262 Seongsanno, Seodaemun-gu, Seoul 120-749 (Korea, Republic of); Translational Research Center for Protein Function Control, Yonsei University, 262 Seongsanno, Seodaemun-gu, Seoul 120-749 (Korea, Republic of)

    2010-10-08

    Research highlights: {yields} NDGA decreases high-fat diet-induced body weight gain and adiposity. {yields} NDGA reduces high-fat diet-induced triglyceride accumulation in liver. {yields} NDGA improves lipid storage in vitro through altering lipid regulatory proteins. {yields} Inhibition of lipid storage in vivo and in vitro is mediated by AMPK activation. -- Abstract: Nonalcoholic fatty liver disease, one of the most common causes of chronic liver disease, is strongly associated with metabolic syndrome. Nordihydroguaiaretic acid (NDGA) has been reported to inhibit lipoprotein lipase; however, the effect of NDGA on hepatic lipid metabolism remains unclear. We evaluated body weight, adiposity, liver histology, and hepatic triglyceride content in high-fat diet (HFD)-fed C57BL/6J mice treated with NDGA. In addition, we characterized the underlying mechanism of NDGA's effects in HepG2 hepatocytes by Western blot and RT-PCR analysis. NDGA (100 or 200 mg/kg/day) reduced weight gain, fat pad mass, and hepatic triglyceride accumulation, and improved serum lipid parameters in mice fed a HFD for 8 weeks. NDGA significantly increased AMP-activated protein kinase (AMPK) phosphorylation in the liver and in HepG2 hepatocytes. NDGA downregulated the level of mature SREBP-1 and its target genes (acetyl-CoA carboxylase and fatty acid synthase), but, it upregulated expression of genes involved in fatty acid oxidation, such as peroxisome proliferator-activated receptor (PPAR){alpha}, PPAR{gamma} coactivator-1, carnitine palmitoyl transferase-1, and uncoupling protein-2. The specific AMPK inhibitor compound C attenuated the effects of NDGA on expression of lipid metabolism-related proteins in HepG2 hepatocytes. The beneficial effects of NDGA on HFD-induced hepatic triglyceride accumulation are mediated through AMPK signaling pathways, suggesting a potential target for preventing NAFLD.

  12. Estimating the potential gains from mergers

    Bogetoft, Peter; Wang, Dexiang

    2005-01-01

    We introduce simple production economic models to estimate the potential gains from mergers. We decompose the gains into technical ef¿ciency, size (scale) and harmony (mix) gains, and we discuss alternative ways to capture these gains. We propose to approximate the production processes using...... the non-parametric. Data Envelopment Analysis (DEA) approach, and we use the resulting operational approach to estimate the potential gains from merging agricultural extension of¿ces in Denmark....

  13. Focal Gains of Vascular Endothelial Growth Factor A and Molecular Classification of Hepatocellular Carcinoma

    Chiang, Derek Y.; Villanueva, Augusto; Hoshida, Yujin; Peix, Judit; Newell, Philippa; Minguez, Beatriz; LeBlanc, Amanda C.; Donovan, Diana J.; Thung, Swan N.; Sole, Manel; Tovar, Victoria; Alsinet, Clara; Ramos, Alex H.; Barretina, Jordi; Roayaie, Sasan; Schwartz, Myron; Waxman, Samuel; Bruix, Jordi; Mazzaferro, Vincenzo; Ligon, Azra H.; Najfeld, Vesna; Friedman, Scott L.; Sellers, William R.; Meyerson, Matthew; Llovet, Josep M.

    2008-01-01

    Hepatocellular carcinomas (HCC) represent the third-leading cause of cancer-related deaths worldwide. The vast majority of cases arise in the context of chronic liver injury due to hepatitis B virus or hepatitis C virus infection. In order to identify genetic mechanisms of hepatocarcinogenesis, we characterized copy number alterations and gene expression profiles from the same set of tumors associated with hepatitis C virus. Most tumors harbored 1q gain, 8q gain or 8p loss, with occasional alterations in 13 additional chromosome arms. In addition to amplifications at 11q13 in 6 of 103 tumors, 4 tumors harbored focal gains at 6p21 incorporating VEGFA. Fluorescence in situ hybridization on an independent validation set of 210 tumors found 6p21 high-level gains in 14 tumors, as well as 2 tumors with 6p21 amplifications. Strikingly, this locus overlapped with copy gains in 4 of 371 lung adenocarcinomas. Overexpression of VEGFA via 6p21 gain in hepatocellular carcinomas suggested a novel, cell-nonautonomous mechanism of oncogene activation. Hierarchical clustering of gene expression among 91 of these tumors identified 5 classes, including ‘CTNNB1’, ‘proliferation’, ‘interferon-related’, and a novel class defined by polysomy of chromosome 7. These class labels were further supported by molecular data: mutations in CTNNB1 were enriched in the ‘CTNNB1’ class, while IGF1R and RPS6 phosphorylation were enriched in the ‘proliferation’ class. The enrichment of signaling pathway alterations in gene expression classes provides insights on HCC pathogenesis. Furthermore, the prevalence of VEGFA high-level gains in multiple tumor types suggests indications for clinical trials of anti-angiogenic therapies. PMID:18701503

  14. Highly active ozonides selected against drug resistant malaria

    Lis Lobo

    2016-01-01

    Full Text Available Ever increasing multi-drug resistance by Plasmodium falciparum is creating new challenges in malaria chemotherapy. In the absence of licensed vaccines, treatment and prevention of malaria is heavily dependent on drugs. Potency, range of activity, safety, low cost and ease of administration are crucial issues in the design and formulation of antimalarials. We have tested three synthetic ozonides NAC89, LC50 and LCD67 in vitro and in vivo against multidrug resistant Plasmodium. In vitro, LC50 was at least 10 times more efficient inhibiting P. falciparum multidrug resistant Dd2 strain than chloroquine and mefloquine and as efficient as artemisinin (ART, artesunate and dihydroartemisinin. All three ozonides showed high efficacy in clearing parasitaemia in mice, caused by multi-drug resistant Plasmodium chabaudi strains, by subcutaneous administration, demonstrating high efficacy in vivo against ART and artesunate resistant parasites.

  15. Highly active ozonides selected against drug resistant malaria

    Lobo, Lis; de Sousa, Bruno; Cabral, Lília; Cristiano, Maria LS; Nogueira, Fátima

    2016-01-01

    Ever increasing multi-drug resistance by Plasmodium falciparum is creating new challenges in malaria chemotherapy. In the absence of licensed vaccines, treatment and prevention of malaria is heavily dependent on drugs. Potency, range of activity, safety, low cost and ease of administration are crucial issues in the design and formulation of antimalarials. We have tested three synthetic ozonides NAC89, LC50 and LCD67 in vitro and in vivo against multidrug resistant Plasmodium. In vitro, LC50 was at least 10 times more efficient inhibiting P. falciparum multidrug resistant Dd2 strain than chloroquine and mefloquine and as efficient as artemisinin (ART), artesunate and dihydroartemisinin. All three ozonides showed high efficacy in clearing parasitaemia in mice, caused by multi-drug resistant Plasmodium chabaudi strains, by subcutaneous administration, demonstrating high efficacy in vivo against ART and artesunate resistant parasites. PMID:27276364

  16. High dielectric constant, low loss and high photocatalytic activity in Gd doped ZnO systems

    Divya, N. K.; Pradyumnan, P. P.

    2017-01-01

    Enhanced photocatalytic activity and high dielectric constant values are achieved by gadolinium (Gd) doping in ZnO. The changes that happened to the wurtzite structure of ZnO on doping are depicted in detail by using x-ray diffraction spectroscopy. The chemical composition is confirmed using energy dispersive x-ray spectroscopy (EDAX). The influence of Gd incorporation in the emission spectra of ZnO is analysed from photoluminescence studies. The photocatalytic activity enhancement occurred in ZnO system on Gd doping was explored by kinetic rate analysis. The optimum incorporation of Gd has enhanced the dielectric constant value and decreased the loss of pristine. The high dielectric constant value and low loss make the system suitable for large scale of applications in microelectronics. The work also proposes large scale synthesis of highly efficient fluorescent Gd doped ZnO photocatalysts.

  17. 1300-nm gain obtained with dysprosium-doped chloride crystals

    Page, R.H.; Schaffers, K.I.; Beach, R.J.; Payne, S.A.; Krupke, W.F.

    1996-03-01

    Dy{sup 3+} - doped chloride crystals have high 1300-nm emission quantum yields. Pump - probe experiments on La Cl{sub 3}:Dy{sup 3+} demonstrate optical gain consistent with predictions based on spectroscopic cross sections and lifetimes.

  18. Gain scaling for multirate filter banks

    Brislawn, Christopher M [Los Alamos National Laboratory

    2009-01-01

    Eliminating two trivial degrees of freedom corresponding to the lowpass DC response and the highpass Nyquist response in a two-channel multirate filter bank seems simple enough. Nonetheless, the ISO/IEC JPEG 2000 image coding standard manages to make this mundane task look totally mysterious. We reveal the true meaning behind JPEG 2000's arcane specifications for filter bank normalization and point out how the seemingly trivial matter of gain scaling leads to highly nontrivial issues concerning uniqueness of lifting factorizations.

  19. Activated carbon fibers with a high heteroatom content by chemical activation of PBO with phosphoric acid.

    Vázquez-Santos, M B; Suárez-García, F; Martínez-Alonso, A; Tascón, J M D

    2012-04-03

    The preparation of activated carbon fibers (ACFs) by phosphoric acid activation of poly(p-phenylene benzobisoxazole) (PBO) fibers was studied, with particular attention to the effects of impregnation ratio and carbonization temperature on porous texture. Phosphoric acid has a strong effect on PBO degradation, lowering the temperature range at which the decomposition takes place and changing the number of mass loss steps. Chemical analysis results indicated that activation with phosphoric acid increases the concentration of oxygenated surface groups; the resulting materials also exhibiting high nitrogen content. ACFs are obtained with extremely high yields; they have well-developed porosity restricted to the micropore and narrow mesopore range and with a significant concentration of phosphorus incorporated homogeneously in the form of functional groups. An increase in the impregnation ratio leads to increases in both pore volume and pore size, maximum values of surface area (1250 m(2)/g) and total pore volume (0.67 cm(3)/g) being attained at the highest impregnation ratio (210 wt % H(3)PO(4)) and lowest activation temperature (650 °C) used; the corresponding yield was as large as 83 wt %. The obtained surface areas and pore volumes were higher than those achieved in previous works by physical activation with CO(2) of PBO chars.

  20. 婴儿乳糖酶活性与肠道菌群对其体重增长的影响%Effect of lactase activity and intestinal microflora on infant's weight gain

    颜引妹; 张燕; 颜雨静; 唐华; 白玲; 陆纯; 汪科

    2013-01-01

    [目的]探讨婴儿乳糖酶活性与肠道菌群对其体重增长的影响,及乳糖酶和益生菌治疗后对其体重增长速率的变化. [方法]从2011年5月-2012年8月期间,从门诊随机收集42 d的体检婴儿共97例(男52,女45),实验组为体弱儿:满月体重增长不足600 g的婴儿共58(男33,女25)例;对照组为体重增长超过600 g家长自愿参加的正常婴儿32例(男19,女13)例,予尿半乳糖测定和粪肠道菌群测定.对实验组给予乳糖酶与益生菌治疗,观察治疗后一月体重增长的变化. [结果]实验组尿半乳糖测定阳性率与对照组比较明显增高(P<0.005),肠道菌群调查显示有失调(P<0.01).提示实验组存在乳糖酶活性低下和肠道菌群紊乱;实验组治疗1月后肠道菌群均>10∶1,体重增长值与对照组比较差异无统计学意义(P>0.05),说明其肠道功能恢复,体重增长速度跟上了对照组. [结论]体弱儿体重增长缓慢的原因之一是乳糖酶活性低下和肠道菌群失调,补充乳糖酶与益生菌是有效的.%[Objective] To investigate the effect of lactase activity and intestinal microflora on infant's weight gain,and the change of weight increasing rate after lactase and probiotics therapy.[Methods] From 2011 June to 2012 August,97 cases of infants (52 males,45 females) under 42 days were randomly collected from outpatients section.The experimental group were 58 cases of frail infants (33 males,25 females) whose weight increase in the first month of birth were less than 600 g; The control group were 32 cases of normal infants (19 males,13 females) volunteered by parents.They were given urinary galaetose and fecal intestinal flora test.The experimental group was given the lactase and probiotics treatment and their weight increase were observed one month later.[Results] The positive rate of urinary galactose test for experimental group was much higher than control group (P<0.005) and intestinal flora showed disorder