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Sample records for activated high gain

  1. High Power VCSEL Device with Periodic Gain Active Region

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    High power vertical cavity surface emitting lasers(VCSEKLs) with large aperture have been fabricated through improving passivation, lateral oxidation and heat dissipation techniques. Different from conventional three quantum well structures, a periodic gain active region with nine quantum wells was incorporated into the VCSEL structure, with which high efficiency and high power operation were expected. The nine quantum wells were divided into three groups with each of them located at the antinodes of the ca...

  2. Photon-activated charge domain in high-gain photoconductive switches

    Institute of Scientific and Technical Information of China (English)

    Wei Shi(施卫); Huiying Dai(戴慧莹); Xiaowei Sun(孙小卫)

    2003-01-01

    We report our experimental observation of charge domain oscillation in semi-insulating GaAs photoconductive semiconductor switches (PCSSs). The high-gain PCSS is intrinsically a photon-activated charge domain device. It is the photon-activated carriers that satisfy the requirement of charge domain formation on carrier concentration and device length product of 1012 cm-2. We also show that, because of the repeated process of domain formation, the domain travels with a compromised speed of electron saturation velocity and the speed of light. As a result, the transit time of charge domains in PCSS is much shorter than that of traditional Gunn domains.

  3. Arctigenin Inhibits Adipogenesis by Inducing AMPK Activation and Reduces Weight Gain in High-Fat Diet-Induced Obese Mice.

    Science.gov (United States)

    Han, Yo-Han; Kee, Ji-Ye; Park, Jinbong; Kim, Hye-Lin; Jeong, Mi-Young; Kim, Dae-Seung; Jeon, Yong-Deok; Jung, Yunu; Youn, Dong-Hyun; Kang, JongWook; So, Hong-Seob; Park, Raekil; Lee, Jong-Hyun; Shin, Soyoung; Kim, Su-Jin; Um, Jae-Young; Hong, Seung-Heon

    2016-09-01

    Although arctigenin (ARC) has been reported to have some pharmacological effects such as anti-inflammation, anti-cancer, and antioxidant, there have been no reports on the anti-obesity effect of ARC. The aim of this study is to investigate whether ARC has an anti-obesity effect and mediates the AMP-activated protein kinase (AMPK) pathway. We investigated the anti-adipogenic effect of ARC using 3T3-L1 pre-adipocytes and human adipose tissue-derived mesenchymal stem cells (hAMSCs). In high-fat diet (HFD)-induced obese mice, whether ARC can inhibit weight gain was investigated. We found that ARC reduced weight gain, fat pad weight, and triglycerides in HFD-induced obese mice. ARC also inhibited the expression of peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer-binding protein alpha (C/EBPα) in in vitro and in vivo. Furthermore, ARC induced the AMPK activation resulting in down-modulation of adipogenesis-related factors including PPARγ, C/EBPα, fatty acid synthase, adipocyte fatty acid-binding protein, and lipoprotein lipase. This study demonstrates that ARC can reduce key adipogenic factors by activating the AMPK in vitro and in vivo and suggests a therapeutic implication of ARC for obesity treatment. J. Cell. Biochem. 117: 2067-2077, 2016. © 2016 Wiley Periodicals, Inc.

  4. The Use of Group Activities in Introductory Biology Supports Learning Gains and Uniquely Benefits High-Achieving Students

    Directory of Open Access Journals (Sweden)

    Gili Marbach-Ad

    2016-12-01

    Full Text Available This study describes the implementation and effectiveness of small-group active engagement (GAE exercises in an introductory biology course (BSCI207 taught in a large auditorium setting. BSCI207 (Principles of Biology III—Organismal Biology is the third introductory core course for Biological Sciences majors. In fall 2014, the instructors redesigned one section to include GAE activities to supplement lecture content. One section (n = 198 employed three lectures per week. The other section (n = 136 replaced one lecture per week with a GAE class. We explored the benefits and challenges associated with implementing GAE exercises and their relative effectiveness for unique student groups (e.g., minority students, high- and low-grade point average [GPA] students. Our findings show that undergraduates in the GAE class exhibited greater improvement in learning outcomes than undergraduates in the traditional class. Findings also indicate that high-achieving students experienced the greatest benefit from GAE activities. Some at-risk student groups (e.g., two-year transfer students showed comparably low learning gains in the course, despite the additional support that may have been afforded by active learning. Collectively, these findings provide valuable feedback that may assist other instructors who wish to revise their courses and recommendations for institutions regarding prerequisite coursework approval policies.

  5. Sudden gains in behavioural activation for depression.

    Science.gov (United States)

    Masterson, Ciara; Ekers, David; Gilbody, Simon; Richards, David; Toner-Clewes, Benjamin; McMillan, Dean

    2014-09-01

    Sudden gains have been linked to improved outcomes in cognitive behaviour therapy for depression. The relationship between sudden gains and outcome is less clear in other treatment modalities, including interpersonal psychotherapy and supportive expressive therapy, which may indicate different mechanisms of change between treatment modalities. The current study examined sudden gains in adults meeting diagnostic criteria for depression (N = 40) offered up to 12 sessions of behavioural activation treatment. Sudden gains were found in 42.5% of the sample. Sudden gains occurred early (median pre-gain session 2) and were related to outcome: those who experienced a sudden gain had significantly lower post-treatment scores on the PHQ-9. Furthermore, the proportion meeting the reliable and clinically significant change criteria at end of treatment was higher in the sudden gain group. These findings highlight the importance of understanding the mechanisms by which sudden gains relate to therapy outcome in behavioural activation.

  6. High-Performance 1.55-µm Superluminescent Diode Based on Broad Gain InAs/InGaAlAs/InP Quantum Dash Active Region

    KAUST Repository

    Khan, Mohammed Zahed Mustafa

    2014-08-01

    We report on the high-performance characteristics from superluminescent diodes (SLDs) based on four-stack InAs/InGaAlAs chirped-barrier thickness quantum dash (Qdash) in a well structure. The active region exhibits a measured broad gain spectrum of 140 nm, with a peak modal gain of ~41 cm-1. The noncoated two-section gainabsorber broad-area and ridge-waveguide device configuration exhibits an output power of > 20 mW and > 12 mW, respectively. The corresponding -3-dB bandwidths span ~82 nm and ~72 nm, with a small spectral ripple of <; 0.2 dB, related largely to the contribution from dispersive height dash ensembles of the highly inhomogeneous active region. These C-L communication band devices will find applications in various cross-disciplinary fields of optical metrology, optical coherent tomography, etc.

  7. Active Microwave Metamaterials Incorporating Ideal Gain Devices

    Directory of Open Access Journals (Sweden)

    Hao Xin

    2010-12-01

    Full Text Available Incorporation of active devices/media such as transistors for microwave and gain media for optics may be very attractive for enabling desired low loss and broadband metamaterials. Such metamaterials can even have gain which may very well lead to new and exciting physical phenomena. We investigate microwave composite right/left-handed transmission lines (CRLH-TL incorporating ideal gain devices such as constant negative resistance. With realistic lumped element values, we have shown that the negative phase constant of this kind of transmission lines is maintained (i.e., left-handedness kept while gain can be obtained (negative attenuation constant of transmission line simultaneously. Possible implementation and challenging issues of the proposed active CRLH-TL are also discussed.

  8. High-Gain Magnetized Inertial Fusion

    Science.gov (United States)

    Slutz, Stephen A.; Vesey, Roger A.

    2012-01-01

    Magnetized inertial fusion (MIF) could substantially ease the difficulty of reaching plasma conditions required for significant fusion yields, but it has been widely accepted that the gain is not sufficient for fusion energy. Numerical simulations are presented showing that high-gain MIF is possible in cylindrical liner implosions based on the MagLIF concept [S. A. Slutz et al Phys. Plasmas 17, 056303 (2010)PHPAEN1070-664X10.1063/1.3333505] with the addition of a cryogenic layer of deuterium-tritium (DT). These simulations show that a burn wave propagates radially from the magnetized hot spot into the surrounding much denser cold DT given sufficient hot-spot areal density. For a drive current of 60 MA the simulated gain exceeds 100, which is more than adequate for fusion energy applications. The simulated gain exceeds 1000 for a drive current of 70 MA.

  9. Gain of harmonic generation in high gain free electron laser

    Institute of Scientific and Technical Information of China (English)

    DENG Hai-Xiao; DAI Zhi-Min

    2008-01-01

    In a planar undulator employed free electron laser(FEL),each harmonic radiation starts from linear amplification and ends with nonlinear harmonic interactions of the lower nonlinear harmonics and the fundamental radiation.In this paper,we investigate the harmonic generation based on the dispersion relation driven from the coupled Maxwell-Vlasov equations,taking into account the effects due to energy spread,emittance,betatron oscillation of electron beam as well as diffraction guiding of the radiation field.A 3D universal scaling function for gain of the linear harmonic generation and a 1D universal scaling function for gain of the nonlinear harmonic generation are presented,which promise rapid computation in FEL design and optimization.The analytical approaches have been validated by 3D simulation results in large range.

  10. Two scale high gain adaptive control

    NARCIS (Netherlands)

    Polderman, Jan W.; Mareels, I.M.Y.; Mareels, Iven

    2004-01-01

    Simple adaptive controllers based on high gain output feedback suffer a lack of robustness with respect to bounded disturbances. Existing modifications achieve boundedness of all solutions but introduce solutions that, even in the absence of disturbances, do not achieve regulation. In this paper a

  11. High fat diet causes rebound weight gain.

    Science.gov (United States)

    McNay, David E G; Speakman, John R

    2012-01-01

    Obesity is at epidemic proportions but treatment options remain limited. Treatment of obesity by calorie restriction (CR) despite having initial success often fails due to rebound weight gain. One possibility is that this reflects an increased body weight (BW) set-point. Indeed, high fat diets (HFD) reduce adult neurogenesis altering hypothalamic neuroarchitecture. However, it is uncertain if these changes are associated with weight rebound or if long-term weight management is associated with reversing this. Here we show that obese mice have an increased BW set-point and lowering this set-point is associated with rescuing hypothalamic remodelling. Treating obesity by CR using HFD causes weight loss, but not rescued remodelling resulting in rebound weight gain. However, treating obesity by CR using non-HFD causes weight loss, rescued remodelling and attenuates rebound weight gain. We propose that these phenomena may explain why successful short-term weight loss improves obesity in some people but not in others.

  12. AN OVERVIEW OF THE DEVELOPMENT OF LOW GAIN FEEDBACK AND LOW-AND-HIGH GAIN FEEDBACK

    Institute of Scientific and Technical Information of China (English)

    Zongli LIN

    2009-01-01

    Low gain feedback refers to certain families of stabilizing state feedback gains that are parameterized in a scalar and go to zero as the scalar decreases to zero. Low gain feedback was initially proposed to achieve semi-global stabilization of linear systems subject to input saturation. It was then combined with high gain feedback in different ways for solving various control problems. The resulting feedback laws are referred to as low-and-high gain feedback. Since the introduction of low gain feedback in the context of semi-global stabilization of linear systems subject to input saturation,there has been effort to develop alternative methods for low gain design, to characterize key features of low gain feedback, and to explore new applications of the low gain and low-and-high gain feedback.This paper reviews the developments in low gain and low-and-high gain feedback designs.

  13. Two-dimensional gain cross-grating based on spatial modulation of active Raman gain

    Science.gov (United States)

    Wang, Li; Zhou, Feng-Xue; Guo, Hong-Ju; Niu, Yue-Ping; Gong, Shang-Qing

    2016-11-01

    Based on the spatial modulation of active Raman gain, a two-dimensional gain cross-grating is theoretically proposed. As the probe field propagates along the z direction and passes through the intersectant region of the two orthogonal standing-wave fields in the x-y plane, it can be effectively diffracted into the high-order directions, and the zero-order diffraction intensity is amplified at the same time. In comparison with the two-dimensional electromagnetically induced cross-grating based on electromagnetically induced transparency, the two-dimensional gain cross-grating has much higher diffraction intensities in the first-order and the high-order directions. Hence, it is more suitable to be utilized as all-optical switching and routing in optical networking and communication. Project supported by the National Natural Science Foundation of China (Grant Nos. 11274112 and 11347133).

  14. Weight gain, physical activity and dietary changes during the seven ...

    African Journals Online (AJOL)

    2011-06-06

    Jun 6, 2011 ... Keywords: Malawi, overweight, obesity, university, weight gain. Weight gain, physical ... The authors sought to assess weight gain, physical activity and ..... 47.1% of children under the age of five years (40.7% in urban, and.

  15. Hybrid optical antenna with high directivity gain.

    Science.gov (United States)

    Bonakdar, Alireza; Mohseni, Hooman

    2013-08-01

    Coupling of a far-field optical mode to electronic states of a quantum absorber or emitter is a crucial process in many applications, including infrared sensors, single molecule spectroscopy, and quantum metrology. In particular, achieving high quantum efficiency for a system with a deep subwavelength quantum absorber/emitter has remained desirable. In this Letter, a hybrid optical antenna based on coupling of a photonic nanojet to a metallo-dielectric antenna is proposed, which allows such efficient coupling. A quantum efficiency of about 50% is predicted for a semiconductor with volume of ~λ³/170. Despite the weak optical absorption coefficient of 2000 cm(-1) in the long infrared wavelength of ~8 μm, very strong far-field coupling has been achieved, as evidenced by an axial directivity gain of 16 dB, which is only 3 dB below of theoretical limit. Unlike the common phased array antenna, this structure does not require coherent sources to achieve a high directivity. The quantum efficiency and directivity gain are more than an order of magnitude higher than existing metallic, dielectric, or metallo-dielectric optical antenna.

  16. High Gain Amplifier with Enhanced Cascoded Compensation

    Directory of Open Access Journals (Sweden)

    J. Lemus-Lopez

    2014-04-01

    Full Text Available A two-stage CMOS operational amplifier with both, gain-boosting and indirect current feedback frequency compensation performed by means of regulated cascode amplifiers, is presented. By using quasi-floating-gate transistors (QFGT the supply requirements, the number of capacitors and the size of the compensation capacitors respect to other Miller schemes are reduced. A prototype was fabricated using a 0.5 μm technology, resulting, for a load of 45 pF and supply voltage of 1.65 V, in open-loop-gain of 129 dB, 23 MHz of gain-bandwidth product, 60o phase margin, 675 μW power consumption and 1% settling time of 28 ns.

  17. Extended High-Gain Observer for Mars Entry Guidance

    Directory of Open Access Journals (Sweden)

    Pingyuan Cui

    2013-02-01

    Full Text Available To deliver a Mars entry vehicle to the prescribed parachute deployment point, active entry guidance is essential. This paper addresses the problem of Mars atmospheric entry guidance through drag tracking method with extended high gain observer. First, an extended high gain observer combined with feedback linearization is applied in drag tracking for Mars entry longitudinal guidance.  The observer estimates the drag and drag rate for drag tracking, estimates the perturbation due to model uncertainty and disturbance, and compensate for the perturbation by canceling its estimate. Then, bank reversal is adopted in the lateral plane to reduce the cross-range error. Finally, Mars entry simulation is performed to assess the performance of the adaptive guidance law. The results demonstrate that the proposed guidance law exhibits good performance.

  18. High-Gain High-Field Fusion Plasma

    Science.gov (United States)

    Li, Ge

    2015-01-01

    A Faraday wheel (FW)—an electric generator of constant electrical polarity that produces huge currents—could be implemented in an existing tokamak to study high-gain high-field (HGHF) fusion plasma, such as the Experimental Advanced Superconducting Tokamak (EAST). HGHF plasma can be realized in EAST by updating its pulsed-power system to compress plasma in two steps by induction fields; high gains of the Lawson trinity parameter and fusion power are both predicted by formulating the HGHF plasma. Both gain rates are faster than the decrease rate of the plasma volume. The formulation is checked by earlier ATC tests. Good agreement between theory and tests indicates that scaling to over 10 T at EAST may be possible by two-step compressions with a compression ratio of the minor radius of up to 3. These results point to a quick new path of fusion plasma study, i.e., simulating the Sun by EAST. PMID:26507314

  19. Physical activity and gestational weight gain in Hispanic women.

    Science.gov (United States)

    Chasan-Taber, Lisa; Silveira, Marushka; Lynch, Kristine E; Pekow, Penelope; Solomon, Caren G; Markenson, Glenn

    2014-03-01

    Hispanic women have high rates of excessive and inadequate gestational weight gain (GWG) according to Institute of Medicine (IOM) guidelines. Observational studies suggest that physical activity may be associated with GWG but have been conflicting and were largely conducted in non-Hispanic white populations. The association between physical activity and compliance with GWG guidelines, total GWG, and rate of GWG among 1,276 Hispanic participants in Proyecto Buena Salud, a cohort study in Western Massachusetts was prospectively evaluated. The Pregnancy Physical Activity Questionnaire was used to assess pre, early, mid, and late pregnancy physical activity according to both intensity (i.e., sedentary, moderate, and vigorous) and type (i.e., housework/caregiving, occupational, and sports/exercise). A total of 26.9% of women gained within IOM guidelines, 21.2% had inadequate GWG, and 51.9% experienced excessive GWG. Overall, we did not observe statistically significant associations between type or intensity of physical activity during pre, early, mid, and late pregnancy and inadequate or excessive GWG, total GWG, or rate of GWG. In this prospective cohort study of Hispanic women, after controlling for important risk factors, pregnancy physical activity did not appear to be associated with GWG. Copyright © 2013 The Obesity Society.

  20. A Unified Approach to High-Gain Adaptive Controllers

    Directory of Open Access Journals (Sweden)

    Ian A. Gravagne

    2009-01-01

    Full Text Available It has been known for some time that proportional output feedback will stabilize MIMO, minimum-phase, linear time-invariant systems if the feedback gain is sufficiently large. High-gain adaptive controllers achieve stability by automatically driving up the feedback gain monotonically. More recently, it was demonstrated that sample-and-hold implementations of the high-gain adaptive controller also require adaptation of the sampling rate. In this paper, we use recent advances in the mathematical field of dynamic equations on time scales to unify and generalize the discrete and continuous versions of the high-gain adaptive controller. We prove the stability of high-gain adaptive controllers on a wide class of time scales.

  1. High gain durable anti-reflective coating

    Energy Technology Data Exchange (ETDEWEB)

    Maghsoodi, Sina; Brophy, Brenor L.; Colson, Thomas E.; Gonsalves, Peter R.; Abrams, Ze' ev R.

    2016-07-26

    Disclosed herein are polysilsesquioxane-based anti-reflective coating (ARC) compositions, methods of preparation, and methods of deposition on a substrate. In one embodiment, the polysilsesquioxane of this disclosure is prepared in a two-step process of acid catalyzed hydrolysis of organoalkoxysilane followed by addition of tetralkoxysilane that generates silicone polymers with >40 mol % silanol based on Si-NMR. These high silanol siloxane polymers are stable and have a long shelf-life in polar organic solvents at room temperature. Also disclosed are low refractive index ARC made from these compositions with and without additives such as porogens, templates, thermal radical initiator, photo radical initiators, crosslinkers, Si--OH condensation catalyst and nano-fillers. Also disclosed are methods and apparatus for applying coatings to flat substrates including substrate pre-treatment processes, coating processes and coating curing processes including skin-curing using hot-air knives. Also disclosed are coating compositions and formulations for highly tunable, durable, highly abrasion-resistant functionalized anti-reflective coatings.

  2. High gain durable anti-reflective coating

    Energy Technology Data Exchange (ETDEWEB)

    Maghsoodi, Sina; Brophy, Brenor L.; Colson, Thomas E.; Gonsalves, Peter R.; Abrams, Ze' ev R.

    2017-06-27

    Disclosed herein are polysilsesquioxane-based anti-reflective coating (ARC) compositions, methods of preparation, and methods of deposition on a substrate. In one embodiment, the polysilsesquioxane of this disclosure is prepared in a two-step process of acid catalyzed hydrolysis of organoalkoxysilane followed by addition of tetralkoxysilane that generates silicone polymers with >40 mol % silanol based on Si-NMR. These high silanol siloxane polymers are stable and have a long shelf-life in polar organic solvents at room temperature. Also disclosed are low refractive index ARC made from these compositions with and without additives such as porogens, templates, thermal radical initiator, photo radical initiators, crosslinkers, Si--OH condensation catalyst and nano-fillers. Also disclosed are methods and apparatus for applying coatings to flat substrates including substrate pre-treatment processes, coating processes and coating curing processes including skin-curing using hot-air knives. Also disclosed are coating compositions and formulations for highly tunable, durable, highly abrasion-resistant functionalized anti-reflective coatings.

  3. Simulation of Nonlinear Gain Saturation in Active Photonic Crystal Waveguides

    DEFF Research Database (Denmark)

    Chen, Yaohui; Mørk, Jesper

    2012-01-01

    In this paper we present a theoretical analysis of slowlight enhanced traveling wave amplification in an active semiconductor Photonic crystal waveguides. The impact of group index on nonlinear modal gain saturation is investigated.......In this paper we present a theoretical analysis of slowlight enhanced traveling wave amplification in an active semiconductor Photonic crystal waveguides. The impact of group index on nonlinear modal gain saturation is investigated....

  4. Nonlinear Gain Saturation in Active Slow Light Photonic Crystal Waveguides

    DEFF Research Database (Denmark)

    Chen, Yaohui; Mørk, Jesper

    2013-01-01

    We present a quantitative three-dimensional analysis of slow-light enhanced traveling wave amplification in an active semiconductor photonic crystal waveguides. The impact of slow-light propagation on the nonlinear gain saturation of the device is investigated.......We present a quantitative three-dimensional analysis of slow-light enhanced traveling wave amplification in an active semiconductor photonic crystal waveguides. The impact of slow-light propagation on the nonlinear gain saturation of the device is investigated....

  5. Gain enhancement in a two-frequency high-gain waveguide free-electron laser

    CERN Document Server

    Lefèvre, T; Rullier, J L; Gouard, P; Donohue, J T

    2002-01-01

    In a waveguide monomode free-electron laser (FEL), two resonant frequencies can be amplified by the electron beam. At the CEA/CESTA facility, single-pass high-gain FEL experiments have been performed over the last five years using relativistic electron beams provided by induction linacs. Most of the work was done in the amplifier regime (at the higher frequency) with the aim of producing a 35 GHz bunched beam. However, super-radiant measurements were also made and have shown that the FEL gain at the upper frequency is higher than in the amplifier regime and may be driven by the lower frequency FEL interaction.

  6. An output amplitude configurable wideband automatic gain control with high gain step accuracy

    Institute of Scientific and Technical Information of China (English)

    何晓丰; 莫太山; 马成炎; 叶甜春

    2012-01-01

    An output amplitude configurable wideband automatic gain control (AGC) with high gain step accuracy for the GNSS receiver is presented.The amplitude of an AGC is configurable in order to cooperate with baseband chips to achieve interference suppression and be compatible with different full range ADCs.And what's more,the gain-boosting technology is introduced and the circuit is improved to increase the step accuracy.A zero,which is composed by the source feedback resistance and the source capacity,is introduced to compensate for the pole.The AGC is fabricated in a 0.18 μm CMOS process.The AGC shows a 62 dB gain control range by 1 dB each step with a gain error of less than 0.2 dB.The AGC provides 3 dB bandwidth larger than 80 MHz and the overall power consumption is less than 1.8 mA,and the die area is 800 × 300μm2.

  7. A SCALE-UP Mock-Up: Comparison of Student Learning Gains in High- and Low-Tech Active-Learning Environments

    Science.gov (United States)

    Soneral, Paula A. G.; Wyse, Sara A.

    2017-01-01

    Student-centered learning environments with upside-down pedagogies (SCALE-UP) are widely implemented at institutions across the country, and learning gains from these classrooms have been well documented. This study investigates the specific design feature(s) of the SCALE-UP classroom most conducive to teaching and learning. Using pilot survey…

  8. Design of a high linearity and high gain accuracy analog baseband circuit for DAB receiver

    Science.gov (United States)

    Li, Ma; Zhigong, Wang; Jian, Xu; Yiqiang, Wu; Junliang, Wang; Mi, Tian; Jianping, Chen

    2015-02-01

    An analog baseband circuit of high linearity and high gain accuracy for a digital audio broadcasting receiver is implemented in a 0.18-μm RFCMOS process. The circuit comprises a 3rd-order active-RC complex filter (CF) and a programmable gain amplifier (PGA). An automatic tuning circuit is also designed to tune the CF's pass band. Instead of the class-A fully differential operational amplifier (FDOPA) adopted in the conventional CF and PGA design, a class-AB FDOPA is specially employed in this circuit to achieve a higher linearity and gain accuracy for its large current swing capability with lower static current consumption. In the PGA circuit, a novel DC offset cancellation technique based on the MOS resistor is introduced to reduce the settling time significantly. A reformative switching network is proposed, which can eliminate the switch resistor's influence on the gain accuracy of the PGA. The measurement result shows the gain range of the circuit is 10-50 dB with a 1-dB step size, and the gain accuracy is less than ±0.3 dB. The OIP3 is 23.3 dBm at the gain of 10 dB. Simulation results show that the settling time is reduced from 100 to 1 ms. The image band rejection is about 40 dB. It only draws 4.5 mA current from a 1.8 V supply voltage.

  9. A Novel High Gain DC-DC Step up Converter

    Directory of Open Access Journals (Sweden)

    M. Al Mamun

    2016-07-01

    Full Text Available High gain dc-dc converters are widely used to maximize the energy harvest for renewable energy systems, for example, photovoltaic systems and fuel cell. Conventional boost converters usually operates at extreme duty cycle to obtain high voltage gain. Operation at extreme duty cycle leads to reverse recovery problem at the switches, high conduction loss, electromagnetic interference etc. This paper proposes a very high gain dc-dc step up converter operating at very low duty cycle (i.e. duty cycle <0.5. The additional advantage of the proposed converter is that a single control signal is used for the switches which reduces the operation complexity. The steady-state theoretical analysis described in this paper is finally verified by simulation results

  10. A SCALE-UP Mock-Up: Comparison of Student Learning Gains in High- and Low-Tech Active-Learning Environments

    Science.gov (United States)

    Soneral, Paula A. G.; Wyse, Sara A.

    2017-01-01

    Student-centered learning environments with upside-down pedagogies (SCALE-UP) are widely implemented at institutions across the country, and learning gains from these classrooms have been well documented. This study investigates the specific design feature(s) of the SCALE-UP classroom most conducive to teaching and learning. Using pilot survey data from instructors and students to prioritize the most salient SCALE-UP classroom features, we created a low-tech “Mock-up” version of this classroom and tested the impact of these features on student learning, attitudes, and satisfaction using a quasi-­experimental setup. The same instructor taught two sections of an introductory biology course in the SCALE-UP and Mock-up rooms. Although students in both sections were equivalent in terms of gender, grade point average, incoming ACT, and drop/fail/withdraw rate, the Mock-up classroom enrolled significantly more freshmen. Controlling for class standing, multiple regression modeling revealed no significant differences in exam, in-class, preclass, and Introduction to Molecular and Cellular Biology Concept Inventory scores between the SCALE-UP and Mock-up classrooms. Thematic analysis of student comments highlighted that collaboration and whiteboards enhanced the learning experience, but technology was not important. Student satisfaction and attitudes were comparable. These results suggest that the benefits of a SCALE-UP experience can be achieved at lower cost without technology features. PMID:28213582

  11. SOFT-SWITCHED HIGH STEP-UP DC-DC CONVERTER WITH HIGH VOLTAGE GAIN

    Directory of Open Access Journals (Sweden)

    J.C. PAUL IMMANUEL

    2013-04-01

    Full Text Available This paper presents a new design of soft switched high step-up dc-dc converter with high voltage gain which is suitable for high power applications such as Uninterruptible Power System (UPS, Photo Voltaic system and hybrid electric vehicles. The emergence of this front-end converter is to improve the shape of active input current given to the system. This converter proposes Soft-Switching technique to achieve ZVS turn on of active switches and ZCS turn off of diodes using Lr - Cr resonance in the auxiliary circuit. Therefore reduces the switching losses. Comparatively the voltage conversion ratio of this converter is higher when compared with the ordinary boost converter. Hence the voltage gain of this converter is also higher. A simulation platform is created using MATLAB which illustrates the ZVS and ZCS operation of the switches and diodes. Open loop and closed loop controlled converter systems are modelled and simulated.

  12. Radiation Response of Emerging High Gain, Low Noise Detectors

    Science.gov (United States)

    Becker, Heidi N.; Farr, William H; Zhu, David Q.

    2007-01-01

    Data illustrating the radiation response of emerging high gain, low noise detectors are presented. Ionizing dose testing of silicon internal discrete avalanche photodiodes, and 51-MeV proton testing of InGaAs/InAlAs avalanche photodiodes operated in Geiger mode are discussed.

  13. Dispersion relations for 1D high-gain FELs

    Energy Technology Data Exchange (ETDEWEB)

    Webb, S.D.; Litvinenko, V.N.

    2010-08-23

    We present analytical results for the one-dimensional dispersion relation for high-gain FELs. Using kappa-n distributions, we obtain analytical relations between the dispersion relations for various order kappa distributions. Since an exact solution exists for the kappa-1 (Lorentzian) distribution, this provides some insight into the number of modes on the way to the Gaussian distribution.

  14. Optimization of Scatterer Concentration in High-Gain Scattering Media

    Institute of Scientific and Technical Information of China (English)

    ZHU Jiu-Gao; ZHU He-Yuan; SUN Die-Chi; DU Ge-Guo; LI Fu-Ming

    2001-01-01

    We report the scatterer concentration-dependent behaviour of laser action in high-gain scattering media. Amodified model of a random laser is proposed to explain the experimental results in good agreement. We mayuse this modified model to design and optimize the random laser system. A further detailed model is needed toquantitatively analyse the far-field distribution of random laser action.

  15. Gain Incorporated Split-Ring Resonator Structures for Active Metamaterials

    Directory of Open Access Journals (Sweden)

    Jordan Chaires

    2015-01-01

    Full Text Available We present a systematic study of split-ring resonator (SRR structures that are used as the basic building blocks of active metamaterials with incorporated gain. The active split-ring resonator (aSRR structures with gain elements can in theory have similar unusual electromagnetic responses such as negative effective permeability near their resonance of the artificial magnetic response just like their passive counterparts. At the same time aSRRs can have reversed imaginary part of the effective permeability and, therefore, mitigate the loss of passive SRRs. We explored in detail both passive and active SRRs through analytic theory, numerical simulations, and lab experimentation and demonstrated that aSRRs can have the similar negative effective permeability responses while reducing and even reversing the loss.

  16. A High Gain Omnidirectional Antenna Using Negative Permeability Metamaterial

    Directory of Open Access Journals (Sweden)

    Hangfei Tang

    2013-01-01

    Full Text Available A high gain omnidirectional antenna with low profile is proposed and is investigated numerically and experimentally. Based on the conventional center-fed circular epsilon-negative (ENG zeroth-order resonator (ZOR antenna, dendritic structure negative permeability metamaterial (NPM is used as the substrate to enhance the gain of the omnidirectional antenna. The experimental results show that the gain of a center-fed circular ENG ZOR antenna with NPM substrate is enhanced about 2.2 dB, and the efficiency is enhanced about 38%, in the whole broad operating bandwidth as compared to that of the antenna without NPM substrate, which can be used to improve the reliability of wireless communications.

  17. High current gain silicon-based spin transistor

    CERN Document Server

    Dennis, C L; Ensell, G J; Gregg, J F; Thompson, S M

    2003-01-01

    A silicon-based spin transistor of novel operating principle has been demonstrated in which the current gain at room temperature is 1.4 (n-type) and 0.97 (p-type). This high current gain was obtained from a hybrid metal/semiconductor analogue to the bipolar junction transistor which functions by tunnel-injecting carriers from a ferromagnetic emitter into a diffusion driven silicon base and then tunnel-collecting them via a ferromagnetic collector. The switching of the magnetic state of the collector ferromagnet controls the collector efficiency and the current gain. Furthermore, the magnetocurrent, which is determined to be 98% (140%) for p-type (n-type) in -110 Oe, is attributable to the spin-polarized base diffusion current.

  18. Silicon photodiodes with high photoconductive gain at room temperature.

    Science.gov (United States)

    Li, X; Carey, J E; Sickler, J W; Pralle, M U; Palsule, C; Vineis, C J

    2012-02-27

    Silicon photodiodes with high photoconductive gain are demonstrated. The photodiodes are fabricated in a complementary metal-oxide-semiconductor (CMOS)-compatible process. The typical room temperature responsivity at 940 nm is >20 A/W and the dark current density is ≈ 100 nA/cm2 at 5 V reverse bias, yielding a detectivity of ≈ 10(14) Jones. These photodiodes are good candidates for applications that require high detection sensitivity and low bias operation.

  19. 20 CFR 416.972 - What we mean by substantial gainful activity.

    Science.gov (United States)

    2010-04-01

    ... INCOME FOR THE AGED, BLIND, AND DISABLED Determining Disability and Blindness Substantial Gainful Activity § 416.972 What we mean by substantial gainful activity. Substantial gainful activity is work activity that is both substantial and gainful: (a) Substantial work activity. Substantial work activity...

  20. Remote Robot Control With High Force-Feedback Gain

    Science.gov (United States)

    Kim, Won S.

    1993-01-01

    Improved scheme for force-reflecting hand control of remote robotic manipulator provides unprecedently high force-reflection gain, even when dissimilar master and slave arms used. Three feedback loops contained in remote robot control system exerting position-error-based force feedback and compliance control. Outputs of force and torque sensors on robot not used directly for force reflection, but for compliance control, while errors in position used to generate reflected forces.

  1. VISA IB Ultra-High Bandwidth, High Gain SASE FEL

    CERN Document Server

    Andonian, Gerard; Murokh, Alex; Pellegrini, Claudio; Reiche, Sven; Rosenzweig, J B; Travish, Gil

    2004-01-01

    The results of a high energy-spread SASE FEL experiment, the intermediary experiment linking the VISA I and VISA II projects, are presented. A highly chirped beam (~1.7%) was transported without correction of longitudinal aberrations in the ATF dogleg, and injected into the VISA undulator. The output FEL radiation displayed an uncharacteristicly large bandwidth (~11%) with extremely stable lasing and measured energy of about 2 microJoules. Start-to-end simulations reproduce key features of the measured results and provide an insight into the mechanisms giving rise to such a high bandwidth. These analyses are described as they relate to important considerations for the VISA II experiment.

  2. STARS A Two Stage High Gain Harmonic Generation FEL Demonstrator

    Energy Technology Data Exchange (ETDEWEB)

    M. Abo-Bakr; W. Anders; J. Bahrdt; P. Budz; K.B. Buerkmann-Gehrlein; O. Dressler; H.A. Duerr; V. Duerr; W. Eberhardt; S. Eisebitt; J. Feikes; R. Follath; A. Gaupp; R. Goergen; K. Goldammer; S.C. Hessler; K. Holldack; E. Jaeschke; Thorsten Kamps; S. Klauke; J. Knobloch; O. Kugeler; B.C. Kuske; P. Kuske; A. Meseck; R. Mitzner; R. Mueller; M. Neeb; A. Neumann; K. Ott; D. Pfluckhahn; T. Quast; M. Scheer; Th. Schroeter; M. Schuster; F. Senf; G. Wuestefeld; D. Kramer; Frank Marhauser

    2007-08-01

    BESSY is proposing a demonstration facility, called STARS, for a two-stage high-gain harmonic generation free electron laser (HGHG FEL). STARS is planned for lasing in the wavelength range 40 to 70 nm, requiring a beam energy of 325 MeV. The facility consists of a normal conducting gun, three superconducting TESLA-type acceleration modules modified for CW operation, a single stage bunch compressor and finally a two-stage HGHG cascaded FEL. This paper describes the faciliy layout and the rationale behind the operation parameters.

  3. Theory of high gain harmonic generation an analytical estimate

    CERN Document Server

    Yu Li Hua

    2002-01-01

    We discuss the theory of the High Gain Harmonic Generation (HGHG). First, we describe an analytical estimate using the HGHG parameters in the DUVFEL project at BNL as an example. We show that the effective energy spread in a chicane dispersion section is found to be very small, and the effect of finite emittance can be neglected during the calculation of coherent harmonic generation. Then we discuss some issues such as the intensity stability, and how to use HGHG to obtain information about local energy spread. We compare these issues with recent experimental results in the infrared. We discuss some of the key issues in the cascading HGHG scheme and its possible limitations.

  4. High-gain, high-bandwidth, rail-to-rail, constant-gm CMOS operational amplifier

    Science.gov (United States)

    Huang, Hong-Yi; Wang, Bo-Ruei

    2013-01-01

    This study presents a high-gain, high-bandwidth, constant-gm , rail-to-rail operational amplifier (op-amp). The constant transconductance is improved with a source-to-bulk bias control of an input pair. A source degeneration scheme is also adapted to the output stage for receiving wide input range without degradation of the gain. Additionally, several compensation schemes are employed to enhance the stability. A test chip is fabricated in a 0.18 µm complementary metal-oxide semiconductor process. The active area of the op-amp is 181 × 173 µm2 and it consumes a power of 2.41 mW at a supply voltage of 1.8 V. The op-amp achieves a dc gain of 94.3 dB and a bandwidth of 45 MHz when the output capacitive load is connected to an effective load of 42.5 pF. A class-AB output stage combining a slew rate (SR) boost circuit provides a sinking current of 6 mA and an SR of 17 V/µs.

  5. Slow-light enhanced gain in active photonic crystal waveguides

    CERN Document Server

    Ek, Sara; Chen, Yaohui; Semenova, Elizaveta; Yvind, Kresten; Mørk, Jesper

    2014-01-01

    Slow light is a fascinating physical effect, raising fundamental questions related to our understanding of light-matter interactions as well as offering new possibilities for photonic devices. From the first demonstrations of slow light propagation in ultra-cold atomic gasses, solid-state Ruby and photonic crystal structures, focus has shifted to applications, with slow light offering the ability to enhance and control light-matter interactions. The demonstration of tuneable delay lines, enhanced nonlinearities and spontaneous emission, enlarged spectral sensitivity and increased phase shifts illustrate the possibilities enabled by slow light propagation, with microwave photonics emerging as one of the promising applications. Here, we demonstrate that slow light can be used to control and increase the gain coefficient of an active semiconductor waveguide. The effect was theoretically predicted but not yet experimentally demonstrated. These results show a route towards realizing ultra-compact optical amplifier...

  6. Slow-light-enhanced gain in active photonic crystal waveguides

    DEFF Research Database (Denmark)

    Ek, Sara; Hansen, Per Lunnemann; Chen, Yaohui

    2014-01-01

    crystal structural parameters, the maximum value of the gain coefficient can be increased compared with a ridge waveguide structure and at the same time the spectral position of the peak gain be controlled. The experimental results are in qualitative agreement with theory and show that gain values similar...... to those realized in state-of-the-art semiconductor optical amplifiers should be attainable in compact photonic integrated amplifiers...

  7. Physical activity and fat mass gain in Mexican school-age children: a cohort study

    Directory of Open Access Journals (Sweden)

    Jáuregui Alejandra

    2012-07-01

    Full Text Available Abstract Background In México, the prevalence of unhealthy weight increased from 24% at 6 y to 33% at 12 y of age, opening a window of opportunity to better understand the pathogenesis of obesity. The objective of this study was to explore the association between time spent on medium, vigorous physical activity (MVPA and concurrent gains in BMI, fat mass (FM and fat-free mass (FFM, alternately, in a cohort of Mexican children followed from kindergarten (baseline to 2nd grade elementary school (endline. Methods The MVPA (5-d accelerometry, BMI, FM and FFM (air displacement plethysmography were measured at baseline and endline. Associations between gains in BMI, FM and FFM and changes in MVPA were examined using lagged and dynamic regression models, controlling for energy intake and demographic variables. Results A total of 205 children were analyzed. Gender affected the effect of MVPA on FM gain. In girls, a high baseline MVPA predicted a lower FM gain (-0.96 kg, p=0.025 compared to low/medium MVPA. Increasing, decreasing or having a persistently high MVPA predicted a lower FM gain (range -1.6 to -1.03 kg, p Conclusion These results support a protective role of MVPA on FM gain in girls, suggesting that it may play a crucial role in the development of obesity. Further research on the gender effect of MVPA is warranted to better understand its role in the prevention and control of overweight and obesity.

  8. Muscle activity during functional coordination training: implications for strength gain and rehabilitation

    DEFF Research Database (Denmark)

    Jørgensen, Marie Birk; Andersen, Lars Louis; Kirk, Niels

    2010-01-01

    The purpose of this study was to evaluate if different types, body positions, and levels of progression of functional coordination exercises can provide sufficiently high levels of muscle activity to improve strength of the neck, shoulder, and trunk muscles. Nine untrained women were familiarized...... training can be performed with a muscle activity sufficient for strength gain. Functional coordination training may therefore be a good choice for prevention or rehabilitation of musculoskeletal pain or injury in the neck, shoulder, or trunk muscles....

  9. Fast ignition integrated experiments and high-gain point design

    Energy Technology Data Exchange (ETDEWEB)

    Shiraga, H. [Osaka Univ., Osaka (Japan); Nagatomo, H. [Osaka Univ., Osaka (Japan); Theobald, W. [Univ. of Rochester, Rochester, NY (United States); Solodov, A. A. [Univ. of Rochester, Rochester, NY (United States); Tabak, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2014-04-17

    Here, integrated fast ignition experiments were performed at ILE, Osaka, and LLE, Rochester, in which a nanosecond driver laser implodes a deuterated plastic shell in front of the tip of a hollow metal cone and an intense ultrashort-pulse laser is injected through the cone to heat the compressed plasma. Based on the initial successful results of fast electron heating of cone-in-shell targets, large-energy short-pulse laser beam lines were constructed and became operational: OMEGA-EP at Rochester and LFEX at Osaka. Neutron enhancement due to heating with a ~kJ short-pulse laser has been demonstrated in the integrated experiments at Osaka and Rochester. The neutron yields are being analyzed by comparing the experimental results with simulations. Details of the fast electron beam transport and the electron energy deposition in the imploded fuel plasma are complicated and further studies are imperative. The hydrodynamics of the implosion was studied including the interaction of the imploded core plasma with the cone tip. Theory and simulation studies are presented on the hydrodynamics of a high-gain target for a fast ignition point design.

  10. Recent progress in high gain InAs avalanche photodiodes (Presentation Recording)

    Science.gov (United States)

    Bank, Seth; Maddox, Scott J.; Sun, Wenlu; Nair, Hari P.; Campbell, Joe C.

    2015-08-01

    InAs possesses nearly ideal material properties for the fabrication of near- and mid-infrared avalanche photodiodes (APDs), which result in strong electron-initiated impact ionization and negligible hole-initiated impact ionization [1]. Consequently, InAs multiplication regions exhibit several appealing characteristics, including extremely low excess noise factors and bandwidth independent of gain [2], [3]. These properties make InAs APDs attractive for a number of near- and mid-infrared sensing applications including remote gas sensing, light detection and ranging (LIDAR), and both active and passive imaging. Here, we discuss our recent advances in the growth and fabrication of high gain, low noise InAs APDs. Devices yielded room temperature multiplication gains >300, with much reduced (~10x) lower dark current densities. We will also discuss a likely key contributor to our current performance limitations: silicon diffusion into the intrinsic (multiplication) region from the underlying n-type layer during growth. Future work will focus on increasing the intrinsic region thickness, targeting gains >1000. This work was supported by the Army Research Office (W911NF-10-1-0391). [1] A. R. J. Marshall, C. H. Tan, M. J. Steer, and J. P. R. David, "Electron dominated impact ionization and avalanche gain characteristics in InAs photodiodes," Applied Physics Letters, vol. 93, p. 111107, 2008. [2] A. R. J. Marshall, A. Krysa, S. Zhang, A. S. Idris, S. Xie, J. P. R. David, and C. H. Tan, "High gain InAs avalanche photodiodes," in 6th EMRS DTC Technical Conference, Edinburgh, Scotland, UK, 2009. [3] S. J. Maddox, W. Sun, Z. Lu, H. P. Nair, J. C. Campbell, and S. R. Bank, "Enhanced low-noise gain from InAs avalanche photodiodes with reduced dark current and background doping," Applied Physics Letters, vol. 101, no. 15, pp. 151124-151124-3, Oct. 2012.

  11. High gain multigap avalanche detectors for Cerenkov ring imaging

    Energy Technology Data Exchange (ETDEWEB)

    Gilmore, R.S.; Lavender, W.M.; Leith, D.W.G.S.; Williams, S.H.

    1980-10-01

    We report on a continuing study of multigap parallel plate avalanche chambers, primarily as photoelectron detectors for use with Cerenkov ring imaging counters. By suitable control of the fields in successive gaps and by introducing screens to reduce photon feedback to the cathode the gain many be increased considerably. We have obtained gains in excess of 6 x 10/sup 7/ for photoelectrons with a good pulse height spectrum and expect to increase this further. We discuss the use of resistive anodes to give avalanche positions in two dimensions by charge division.

  12. Role of surface in high photoconductive gain measured in ZnO nanowire-based photodetector

    Energy Technology Data Exchange (ETDEWEB)

    Mallampati, Bhargav [University of North Texas, Department of Electrical Engineering (United States); Nair, S. V.; Ruda, H. E. [University of Toronto, Centre for Advanced Nanotechnology (Canada); Philipose, U., E-mail: usha.philipose@unt.edu [University of North Texas, Department of Physics (United States)

    2015-04-15

    On account of their large surface-to-volume ratio, nanowires contain an extremely high density of surface states which can lead to significantly enhanced photocarrier lifetimes resulting in persistent photoconductivity. There are reports that attribute the high photoconductive gain of ZnO nanowire-based photodetectors to hole trapping and de-trapping following oxygen adsorption and desorption from the nanowire surface. Through this work we provide experimental evidence of the role of surface and defects in carrier dynamics, resulting in enhanced photoresponse. ZnO nanowires with an average length of about 20 μm and diameters in the range of 60–80 nm were used in this experiment. Using intensity and temperature dependence of the rise and decay rate of photocurrent, we present a detailed analysis that provides an estimate of the activation energies of carrier trapping mechanisms. The high gain ZnO nanowire photodetector was sensitive to photoexcitation at or below 370 nm corresponding to the band-edge absorption profile of ZnO. At an incident wavelength of 370 nm and at a bias field of 5 kV/cm, it was found that the maximum responsivity is over 10{sup 5} A/W corresponding to an extremely high photoconductive gain of the order of 10{sup 6}. This corresponds to a normalized photoconductive gain of 4 × 10{sup −3} m{sup 2}V{sup −1}.

  13. High Peak Power Gain Switched Flared Waveguide Lasers

    Energy Technology Data Exchange (ETDEWEB)

    Chow, W.W.; Indik, R.; Koch, S.W.; Mar, Alan, Vawter, G. Allen; Moloney, J.

    1999-08-05

    We gain-switch flared waveguide lasers to obtain 14.5 W peak powers and 0.5 nJ pulse energies with laser structures compatible with the generation of diffraction-limited beams. The results are in excellent agreement with a microscopic laser model.

  14. 26 CFR 7.105-2 - Substantial gainful activity.

    Science.gov (United States)

    2010-04-01

    ....105-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) TEMPORARY INCOME TAX REGULATIONS UNDER THE TAX REFORM ACT OF 1976 § 7.105-2 Substantial gainful... minimum wage prescribed by section 6(a)(1) of the Fair Labor Standards Act of 1938, as amended, 29 U.S.C...

  15. Relationship of serum somatomedin-like activity and fibroblast proliferative activity with age and body weight gain in sheep.

    Science.gov (United States)

    Olsen, R F; Wangsness, P J; Patton, W H; Martin, R J

    1981-01-01

    The relationship between serum growth factors and body weight gain was examined in five Dorset lambs. The lambs were weighed and bled by jugular puncture at 2-week intervals between 2 and 18 weeks of age. Somatomedin-like activity (Sm) declined from initially high concentrations at 2 weeks to fairly constant concentrations between 6 and 18 weeks. Relative weight gain--i.e., gain expressed as a percentage of body weight--declined in a manner similar to that of Sm. Mean relative weight gain and mean Sm for the eight 2-week intervals were significantly related (r = .84). Absolute body weight gain--i.e., gain expressed in kilograms--remained fairly constant throughout the study and was not significantly correlated to Sm (r = .15). Serum fibroblast proliferative activity (FPA) was measured as a possible indicator of collective activities of serum growth factors. FPA initially followed a pattern similar to that of Sm, decreasing between 2 and 6 weeks and plateauing until 12 weeks. After 12 weeks, FPA increased to concentrations similar to those observed at 2 weeks. The increase in FPA after 12 weeks was apparently due to an increase in a non-Sm growth factor and had no obvious relationship to body weight changes. Results of the in vitro cell assay system might have been more meaningful if cell type(s) other than WI-38 fibroblasts (e.g., myogenic cells) had been used for estimating collective activities of serum mitogenic factors. The data suggest that serum Sm-like activity may be important in the regulation of growth in sheep.

  16. High Gain and High Directive of Antenna Arrays Utilizing Dielectric Layer on Bismuth Titanate Ceramics

    Directory of Open Access Journals (Sweden)

    F. H. Wee

    2012-01-01

    Full Text Available A high gain and high directive microstrip patch array antenna formed from dielectric layer stacked on bismuth titanate (BiT ceramics have been investigated, fabricated, and measured. The antennas are designed and constructed with a combination of two-, four-, and six-BiT elements in an array form application on microwave substrate. For gain and directivity enhancement, a layer of dielectric was stacked on the BiT antenna array. We measured the gain and directivity of BiT array antennas with and without the dielectric layer and found that the gain of BiT array antenna with the dielectric layer was enhanced by about 1.4 dBi of directivity and 1.3 dB of gain over the one without the dielectric layer at 2.3 GHz. The impedance bandwidth of the BiT array antenna both with and without the dielectric layer is about 500 MHz and 350 MHz, respectively, which is suitable for the application of the WiMAX 2.3 GHz system. The utilization of BiT ceramics that covers about 90% of antenna led to high radiation efficiency, and small-size antennas were produced. In order to validate the proposed design, theoretical and measured results are provided and discussed.

  17. Losses, gain, and lasing in organic and perovskite active materials (Conference Presentation)

    Science.gov (United States)

    Pourdavoud, Neda; Riedl, Thomas J.

    2016-09-01

    Organic solid state lasers (OSLs) based on semiconducting polymers or small molecules have seen some significant progress over the past decade. Highly efficient organic gain materials combined with high-Q resonator geometries (distributed feedback (DFB), VCSEL, etc.) have enabled OSLs, optically pumped by simple inorganic laser diodes or even LEDs. However, some fundamental goals remain to be reached, like continuous wave (cw) operation and injection lasing. I will address various loss mechanisms related to accumulated triplet excitons or long-lived polarons that in combination with the particular photo-physics of organic gain media state the dominant road-blocks on the way to reach these goals. I will discuss the recent progress in fundamental understanding of these loss processes, which now provides a solid basis for modelling, e.g. of laser dynamics. Avenues to mitigate these fundamental loss mechanisms, e.g. by alternative materials will be presented. In this regard, a class of gain materials based on organo-lead halide perovskites re-entered the scene as light emitters, recently. Enjoying a tremendous lot of attention as active material for solution processed solar cells with a 20+% efficiency, they have recently unveiled their exciting photo-physics for lasing applications. Optically pumped lasing in these materials has been achieved. I will discuss some of the unique properties that render this class of materials a promising candidate to overcome some of the limitations of "classical" organic gain media.

  18. High Energy Gain IFEL at UCLA Neptune Laboratory

    CERN Document Server

    Musumeci, Pietro; Clayton, Chris; Doyuran, Adnan; England, Robert J; Joshi, Chandrashekhar; Pellegrini, Claudio; Ralph, Joseph; Rosenzweig, James E; Sung, Chieh; Tochitsky, Sergei Ya; Tolmachev, Sergey; Travish, Gil; Varfolomeev, A; Varfolomeev, Alexander; Yarovoi, Timofey V; Yoder, Rodney

    2005-01-01

    We report the observation of energy gain in excess of 20 MeV at the Inverse Free Electron Laser Accelerator experiment at the Neptune Laboratory at UCLA. A 14.5 MeV electron beam is injected in an undulator strongly tapered in period and field amplitude. The IFEL driver is a CO2 10.6 mkm laser with power larger than 400 GW. The Rayleigh range of the laser, ~ 1.8 cm, is much shorter than the undulator length so that the interaction is diffraction dominated. A few per cent of the injected particles are trapped in a stable accelerating bucket. Electrons with energies up to 35 MeV are measured by a magnetic spectrometer. Simulations, in good agreement with the experimental data, show that most of the energy gain occurs in the first half of the undulator at a gradient of 70 MeV/m and that the structure in the measured energy spectrum arises because of higher harmonic IFEL interaction in the second half of the undulator.

  19. A novel design of ultra-broadband, high-gain and high-linearity variable gain distributed amplifier in 0.13 μm CMOS technology

    Science.gov (United States)

    Baharvand, Zainab; Hakimi, Ahmad; Rashedi, Esmat

    2016-12-01

    A high-gain, high-linearity and ultra-broadband variable gain distributed amplifier (VGDA) based on employing multiple techniques is presented to substantially increase the gain. The complete design is composed of two major parts including a VGDA part followed by a single stage distributed amplifier (SSDA) part. The VGDA part makes it possible to achieve different gain settings. For high gain considerations, the SSDA part cascades with the VGDA part that takes the benefits of the multiplicative gain mechanism. A theory is presented to enhance the linearity without imposing further DC power consumption. This idea has been validated by simulation results as expected. The design is analysed and simulated in the standard 0.13 μm CMOS technology. It presents the large gain tuning range of 35 dB, from -5 dB attenuation gain up to +30 dB maximum amplification gain, in relation to the control voltage (Vctr) that varies between 0.42 and 1.1 V. At the maximum amplification gain setting, it presents a DC up to 16 GHz 3 dB bandwidth, an average noise figure of 3.2 dB and an IIP3 of -2 dB m. Furthermore, it dissipates 46.42 mW from 0.7 and 0.9 V power supplies of the drain lines of VGDA and SSDA parts, respectively. Additionally, the Monte Carlo (MC) simulation has been performed to predict an estimate of the accuracy of performance of the proposed design under various conditions.

  20. There Is No Further Gain from Calculating Disease Activity Score in 28 Joints with High Sensitivity Assays of C-Reactive Protein Because of High Intraindividual Variability of CRP

    DEFF Research Database (Denmark)

    Jensen Hansen, Inger Marie; Asmussen Andreasen, Rikke; Antonsen, Steen

    2016-01-01

    Background/Purpose: The threshold for reporting of C-reactive protein (CRP) differs from laboratory to laboratory. Moreover, CRP values are affected by the intra individual biological variability.[1] With respect to disease activity score in 28 joints (DAS28) and Rheumatoid Arthritis (RA), precise...... reporting limit for CRP to minimumFigure 1). The logarithmic transformation of CRP in DAS28 formula has an important role Cross sectional study: 769 patients fulfilled the ACR criteria for RA were included, 107 excluded due to missing parameter used...

  1. There Is No Further Gain from Calculating Disease Activity Score in 28 Joints with High Sensitivity Assays of C-Reactive Protein Because of High Intraindividual Variability of CRP: A Cross Sectional Study and Theoretical Consideration

    DEFF Research Database (Denmark)

    Jensen Hansen, Inger Marie; Asmussen Andreasen, Rikke; Antonsen, Steen

    Background/Purpose: The threshold for reporting of C-reactive protein (CRP) differs from laboratory to laboratory. Moreover, CRP values are affected by the intra individual biological variability.[1] With respect to disease activity score in 28 joints (DAS28) and Rheumatoid Arthritis (RA), precise...... reporting limit for CRP to minimumFigure 1). The logarithmic transformation of CRP in DAS28 formula has an important role Cross sectional study: 769 patients fulfilled the ACR criteria for RA were included, 107 excluded due to missing parameter used...

  2. SIW HIGH GAIN SLOT ANTENNA FOR WLAN/WIMAX APPLICATION

    Directory of Open Access Journals (Sweden)

    Neda Akbari

    2014-01-01

    Full Text Available In this paper with using substrate integrated waveguide technology and slot antenna, an antenna array with 8 (2×4 elements has been designed. The antenna substrate is ROGERs 4003 with two different thickness. In lower substrate with 0.5 mm thickness fed network of antenna is putted and upper substrate with 1.5 mm thickness slot in order to radation is embedded. The proposed antenna is designed in C band for WLAN/WiMAX application. Pattern of antenna is directive with peak gain about 18dBi. In feed netowork is used from new method of feeding with using of aperture couple and cavity resonator method.

  3. Exploring sudden gains in behavioral activation therapy for Major Depressive Disorder.

    Science.gov (United States)

    Hunnicutt-Ferguson, Kallio; Hoxha, Denada; Gollan, Jackie

    2012-03-01

    Understanding the onset and course of sudden gains in treatment provides clinical information to the patient and clinician, and encourages clinicians to strive for these sudden clinical gains with their patients. This study characterizes the occurrence of sudden gains with Behavioral Activation (BA; Martell, Addis, & Jacobson, 2001), and the extent to which pre-treatment dysfunctional depressive thinking predicts sudden gains during treatment. We enrolled a sample of adults (n = 42) between ages 18-65 diagnosed with primary Major Depressive Disorder. All participants completed a 16-week course of BA, with clinical and self-report assessments at pre-, mid- and post-treatment. Results indicated that sudden gain and non-sudden gain participants showed differential improvement across treatment. No significant effects emerged for the dysfunctional cognitive style as a predictor of sudden gain status. Sudden gains may result from interaction of non-specific factors with the BA techniques implemented during early phases of therapy.

  4. 20 CFR 229.85 - Substantial gainful activity by blind employee or child.

    Science.gov (United States)

    2010-04-01

    ... in any type of substantial gainful activity which requires skills or abilities comparable to those of... THE RAILROAD RETIREMENT ACT SOCIAL SECURITY OVERALL MINIMUM GUARANTEE Miscellaneous Deductions and... substantial gainful activity that does not require skills or ability used in his or her previous work. However...

  5. The Gain Properties of 1-D Active Photonic Crystal

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    The terminology 'ID frequency'(w ID) is proposed after analyzing the 1D active photonic crystal based on the transfer matrix method. The relationship between wID and the structure parameters of the photonic crystal is investigated.

  6. A novel "gain chip" concept for high-power lasers (Conference Presentation)

    Science.gov (United States)

    Li, Min; Li, Mingzhong; Wang, Zhenguo; Yan, Xiongwei; Jiang, Xinying; Zheng, Jiangang; Cui, Xudong; Zhang, Xiaomin

    2017-05-01

    High-power lasers, including high-peak power lasers (HPPL) and high-average power lasers (HAPL), attract much interest for enormous variety of applications in inertial fusion energy (IFE), materials processing, defense, spectroscopy, and high-field physics research. To meet the requirements of high efficiency and quality, a "gain chip" concept is proposed to properly design the pumping, cooling and lasing fields. The gain chip mainly consists of the laser diode arrays, lens duct, rectangle wave guide and slab-shaped gain media. For the pumping field, the pump light will be compressed and homogenized by the lens duct to high irradiance with total internal reflection, and further coupled into the gain media through its two edge faces. For the cooling field, the coolant travels along the flow channel created by the adjacent slabs in the other two edge-face direction, and cool the lateral faces of the gain media. For the lasing field, the laser beam travels through the lateral faces and experiences minimum thermal wavefront distortions. Thereby, these three fields are in orthogonality offering more spatial freedom to handle them during the construction of the lasers. Transverse gradient doping profiles for HPPL and HAPL have been employed to achieve uniform gain distributions (UGD) within the gain media, respectively. This UGD will improve the management for both amplified spontaneous emission (ASE) and thermal behavior. Since each "gain chip" has its own pump source, power scaling can be easily achieved by placing identical "gain chips" along the laser beam axis without disturbing the gain and thermal distributions. To detail our concept, a 1-kJ pulsed amplifier is designed and optical-to-optical efficiency up to 40% has been obtained. We believe that with proper coolant (gas or liquid) and gain media (Yb:YAG, Nd:glass or Nd:YAG) our "gain chip" concept might provide a general configuration for high-power lasers with high efficiency and quality.

  7. High Gain Patch Antenna for 2.4GHz using Metamaterial Superstrate

    Institute of Scientific and Technical Information of China (English)

    Kyu-Chang; LEE; Seung-In; YANG

    2010-01-01

    <正>A patch antenna and our proposed metamaterial patch antenna are simulated and compared. A high gain patch antenna using a single layer metamaterial superstrate with a near to zero refractive index(n)is proposed.The simulation results provide that the gain of the proposed antenna is increased by about 7dB. Consequently,the high gain antenna can be easily obtained by using our metamaterial superstrate.

  8. High gain 1.3-μm GaInNAs SOA with fast gain dynamics and enhanced temperature stability

    Science.gov (United States)

    Fitsios, D.; Giannoulis, G.; Iliadis, N.; Korpijärvi, V.-M.; Viheriälä, J.; Laakso, A.; Dris, S.; Spyropoulou, M.; Avramopoulos, H.; Kanellos, G. T.; Pleros, N.; Guina, M.

    2014-03-01

    Semiconductor optical amplifiers (SOAs) are a well-established solution of optical access networks. They could prove an enabling technology for DataCom by offering extended range of active optical functionalities. However, in such costand energy-critical applications, high-integration densities increase the operational temperatures and require powerhungry external cooling. Taking a step further towards improving the cost and energy effectiveness of active optical components, we report on the development of a GaInNAs/GaAs (dilute nitride) SOA operating at 1.3μm that exhibits a gain value of 28 dB and combined with excellent temperature stability owing to the large conduction band offset between GaInNAs quantum well and GaAs barrier. Moreover, the characterization results reveal almost no gain variation around the 1320 nm region for a temperature range from 20° to 50° C. The gain recovery time attained values as short as 100 ps, allowing implementation of various signal processing functionalities at 10 Gb/s. The combined parameters are very attractive for application in photonic integrated circuits requiring uncooled operation and thus minimizing power consumption. Moreover, as a result of the insensitivity to heating issues, a higher number of active elements can be integrated on chip-scale circuitry, allowing for higher integration densities and more complex optical on-chip functions. Such component could prove essential for next generation DataCom networks.

  9. High Gain Hybrid Graphene-Organic Semiconductor Phototransistors

    NARCIS (Netherlands)

    Huisman, Everardus H.; Shulga, Artem G.; Zomer, Paul J.; Tombros, Nikolaos; Bartesaghi, Davide; Bisri, Satria Zulkarnaen; Loi, Maria A.; Koster, L. Jan Anton; van Wees, Bart J.

    2015-01-01

    Hybrid phototransistors of graphene and the organic semiconductor poly(3-hexylthiophene-2,5-diyl) (P3HT) are presented. Two types of phototransistors are demonstrated with a charge carrier transit time that differs by more than 6 orders of magnitude. High transit time devices are fabricated using a

  10. High gain durable anti-reflective coating with oblate voids

    Energy Technology Data Exchange (ETDEWEB)

    Maghsoodi, Sina; Brophy, Brenor L.; Colson, Thomas E.; Gonsalves, Peter R.; Abrams, Ze' ev

    2016-06-28

    Disclosed herein are single layer transparent coatings with an anti-reflective property, a hydrophobic property, and that are highly abrasion resistant. The single layer transparent coatings contain a plurality of oblate voids. At least 1% of the oblate voids are open to a surface of the single layer transparent coatings.

  11. Optically-gated Non-latched High Gain Power Device

    Science.gov (United States)

    2008-11-21

    INTENSITY MODULATION OF PSD SWITCHING DYNAMICS 39 5.1. Optically-modulated Active Gate Control (OMAG) architecture for full controllability of turn-on... architecture for next- generation avionics, electromagnetic interference (EMI) is a critical issue [2, 3]. EMI immunity of these actuators from external jamming...TlissMT (o] Ns * I utut*n I/a^l Rh-( J.52«5E»84 [ mVC ] I 0«| 1.20S2JE-02 [I/O cm] aloha =| 07t627 Ml: Bulk concenfcation M • Mobility O ! Bull

  12. Stabilization of sandwich non-linear systems with low-and-high gain feedback design

    NARCIS (Netherlands)

    Stoorvogel, Anton A.; Wang, Xu; Saberi, Ali; Sannuti, Peddapullaiah

    2010-01-01

    In this paper, we consider the problems of semi- global and global internal stabilization of a class of sandwich systems consisting of two linear systems with a saturation element in between. We develop here low-and-high gain and scheduled low-and-high gain state feedback design methodolo- gies to s

  13. Highly efficient multifunctional metasurface for high-gain lens antenna application

    Science.gov (United States)

    Hou, Haisheng; Wang, Guangming; Li, Haipeng; Guo, Wenlong; Li, Tangjing

    2017-07-01

    In this paper, a novel multifunctional metasurface combining linear-to-circular polarization conversion and electromagnetic waves focusing has been proposed and applied to design a high-gain lens antenna working at Ku band. The multifunctional metasurface consists of 15 × 15 unit cells. Each unit cell is composed of four identical metallic layers and three intermediate dielectric layers. Due to well optimization, the multifunctional metasurface can convert the linearly polarized waves generated by the source to circularly polarized waves and focus the waves. By placing a patch antenna operating at 15 GHz at the focal point of the metasurface and setting the focal distance to diameter ratio ( F/ D) to 0.34, we obtain a multifunctional lens antenna. Simulated and measured results coincide well, indicating that the metasurface can convert linearly polarized waves to right-handed circularly polarized waves at 15 GHz with excellent performances in terms of the 3 dB axial ratio bandwidth of 5.3%, realized gain of 16.9 dB and aperture efficiency of 41.2%. Because of the advantages of high gain, competitive efficiency and easy fabrication, the proposed lens antenna has a great potential application in wireless and satellite communication.

  14. Avalanche effect and gain saturation in high harmonic generation

    CERN Document Server

    Serrat, Carles; Budesca, Josep M; Seres, Jozsef; Seres, Enikoe; Aurand, Bastian; Hoffmann, Andreas; Namba, Shinichi; Kuehl, Thomas; Spielmann, Christian

    2015-01-01

    Optical amplifiers in all ranges of the electromagnetic spectrum exhibit two essential characteristics: i) the input signal during the propagation in the medium is multiplied by the avalanche effect of the stimulated emission to produce exponential growth and ii) the amplification saturates at increasing input signal. We demonstrate that the strong-field theory in the frame of high harmonic generation fully supports the appearance of both the avalanche and saturation effects in the amplification of extreme ultraviolet attosecond pulse trains. We confirm that the amplification takes place only if the seed pulses are perfectly synchronized with the driving strong field in the amplifier. We performed an experimental study and subsequent model calculation on He gas driven by intense 30-fs-long laser pulses, which was seeded with an attosecond pulse train at 110 eV generated in a separated Ne gas jet. The comparison of the performed calculations with the measurements clearly demonstrates that the pumped He gas med...

  15. High-gain Yb:YAG amplifier for ultrashort pulse laser at high-average power

    Science.gov (United States)

    Vetrovec, John; Copeland, Drew A.; Litt, Amardeep S.; Du, Detao

    2016-03-01

    We report on a Yb:YAG laser amplifier for ultrashort pulse applications at kW-class average power. The laser uses two large-aperture, disk-type gain elements fabricated from composite ceramic YAG material, and a multi-pass extraction architecture to obtain high gain in a chirped-pulse amplification system. The disks are edge-pumped, thus allowing for reduced doping of host material with laser ions, which translates to lower lasing threshold and lower heat dissipation in the Yb:YAG material. The latter makes it possible to amplify a near diffraction-limited seed without significant thermo-optical distortions. This work presents results of testing the laser amplifier with relay optics configured for energy extraction with up to 40 passes through the disks. Applications for the ultrashort pulse laser amplifier include producing laser-induced plasma channel, laser material ablation, and laser acceleration of atomic particles.

  16. The influence of loss and gain of body mass on ovarian activity in ...

    African Journals Online (AJOL)

    The influence of loss and gain of body mass on ovarian activity in beef cows. B.P. Louw* and C.R. .... maintenance of body mass for a 90-day period; Phase 3, rapid mass gain until ..... weight and reduction of its effect on weighing. Anim. Breed.

  17. Effects of high CO2 levels on dynamic photosynthesis: carbon gain, mechanisms, and environmental interactions.

    Science.gov (United States)

    Tomimatsu, Hajime; Tang, Yanhong

    2016-05-01

    Understanding the photosynthetic responses of terrestrial plants to environments with high levels of CO2 is essential to address the ecological effects of elevated atmospheric CO2. Most photosynthetic models used for global carbon issues are based on steady-state photosynthesis, whereby photosynthesis is measured under constant environmental conditions; however, terrestrial plant photosynthesis under natural conditions is highly dynamic, and photosynthetic rates change in response to rapid changes in environmental factors. To predict future contributions of photosynthesis to the global carbon cycle, it is necessary to understand the dynamic nature of photosynthesis in relation to high CO2 levels. In this review, we summarize the current body of knowledge on the photosynthetic response to changes in light intensity under experimentally elevated CO2 conditions. We found that short-term exposure to high CO2 enhances photosynthetic rate, reduces photosynthetic induction time, and reduces post-illumination CO2 burst, resulting in increased leaf carbon gain during dynamic photosynthesis. However, long-term exposure to high CO2 during plant growth has varying effects on dynamic photosynthesis. High levels of CO2 increase the carbon gain in photosynthetic induction in some species, but have no significant effects in other species. Some studies have shown that high CO2 levels reduce the biochemical limitation on RuBP regeneration and Rubisco activation during photosynthetic induction, whereas the effects of high levels of CO2 on stomatal conductance differ among species. Few studies have examined the influence of environmental factors on effects of high levels of CO2 on dynamic photosynthesis. We identified several knowledge gaps that should be addressed to aid future predictions of photosynthesis in high-CO2 environments.

  18. High speed InAs electron avalanche photodiodes overcome the conventional gain-bandwidth product limit.

    Science.gov (United States)

    Marshall, Andrew R J; Ker, Pin Jern; Krysa, Andrey; David, John P R; Tan, Chee Hing

    2011-11-07

    High bandwidth, uncooled, Indium Arsenide (InAs) electron avalanche photodiodes (e-APDs) with unique and highly desirable characteristics are reported. The e-APDs exhibit a 3dB bandwidth of 3.5 GHz which, unlike that of conventional APDs, is shown not to reduce with increasing avalanche gain. Hence these InAs e-APDs demonstrate a characteristic of theoretically ideal electron only APDs, the absence of a gain-bandwidth product limit. This is important because gain-bandwidth products restrict the maximum exploitable gain in all conventional high bandwidth APDs. Non-limiting gain-bandwidth products up to 580 GHz have been measured on these first high bandwidth e-APDs.

  19. Study on Dielectric Resonator Antenna with Annular Patch for High Gain and Large Bandwidth

    Institute of Scientific and Technical Information of China (English)

    FENG Kuisheng; LI Na; MENG Qingwei; WANG Yongfeng; ZHANG Jingwei

    2015-01-01

    A new high-gain cylindrical Dielectric res-onator antenna (DRA) with a large bandwidth is proposed. A cylindrical Dielectric resonator (DR), a double-annular patch and a metallic cylinder are used to obtain a large bandwidth and a high gain. The mode TM12 excited in the patch is used to enhance the gain of the DRA, and the cavity formed by the metallic cylinder provides a further higher gain and a larger bandwidth. The measured results demonstrate that the proposed DRA achieves a large band-width of 23%from 5.3 to 6.8GHz with VSWR less than two and a high gain around 11 dBi.

  20. The Design of High-Q Sallen-Key Biquads with Unity-Gain Buffer Amplifiers

    DEFF Research Database (Denmark)

    Gaunholt, Hans; Guldbrandsen, Birthe

    1997-01-01

    and to implement the Sallen- Key biquad even in the high-Q case with reasonable sensitivities. The method is based on the unity gain version of the biquad and as unity gain buffer amplifiers are readily manufactured in integrated circuit technology the results may be very useful in the fabrication of integrated...

  1. Effect of the upper limbs muscles activity on the mechanical energy gain in pole vaulting.

    Science.gov (United States)

    Frère, Julien; Göpfert, Beat; Slawinski, Jean; Tourny-chollet, Claire

    2012-04-01

    The shoulder muscles are highly solicited in pole vaulting and may afford energy gain. The objective of this study was to determine the bilateral muscle activity of the upper-limbs to explain the actions performed by the vaulter to bend the pole and store elastic energy. Seven experienced athletes performed 5-10 vaults which were recorded using two video cameras (50Hz). The mechanical energy of the centre of gravity (CG) was computed, while surface electromyographic (EMG) profiles were recorded from 5 muscles bilateral: deltoideus, infraspinatus, biceps brachii, triceps, and latissimus dorsi muscles. The level of intensity from EMG profile was retained in four sub phases between take-off (TO1) and complete pole straightening (PS). The athletes had a mean mechanical energy gain of 22% throughout the pole vault, while the intensities of deltoideus, biceps brachii, and latissimus dorsi muscles were sub phases-dependent (pmechanical energy of the vaulter could be linked to an increase in muscle activation, especially from latissimusdorsi muscles. Copyright © 2011 Elsevier Ltd. All rights reserved.

  2. Antenatal weight management: Diet, physical activity, and gestational weight gain in early pregnancy.

    Science.gov (United States)

    Swift, Judy A; Langley-Evans, Simon C; Pearce, Jo; Jethwa, Preeti H; Taylor, Moira A; Avery, Amanda; Ellis, Sarah; McMullen, Sarah; Elliott-Sale, Kirsty J

    2017-06-01

    to investigate women's physical activity levels, diet and gestational weight gain, and their experiences and motivations of behavior change. analysis of cross-sectional data collected during a longitudinal, cohort study examining physiological, psychological, sociodemographic, and self-reported behavioural measures relating to bodyweight. women recruited from routine antenatal clinics at the Nottingham University Hospitals NHS Trust. 193 women ≤27 weeks gestation and aged 18 years or over. MEASUREMENTS & FINDINGS: measurements included weight and height, the Dietary Instrument for Nutrition Education (Brief Version), the International Physical Activity Questionnaire (Short Form), and open questions of perceptions of behaviour change. 50.3% (n=97) were overweight/obese, and women gained 0.26kg/wk (IQR 0.34kg/wk) since conception. The majority consumed low levels of fat (n=121; 63.4%), high levels of unsaturated fat (n=103; 53.9%), and used a dietary supplement (n=166; 86.5%). However, 41% (n=76) were inactive, 74.8% (n=143) did not consume high levels of fibre, and 90.0% (n=171) consumed less than 5 portions of fruit and vegetables a day. Body mass index category was not associated with diet, physical activity levels, or gestational weight gain. Themes generated from open-questions relating to behaviour change were: (1) Risk management, (2) Coping with symptoms, (3) Self-control, (4) Deviation from norm, (5) Nature knows best. early pregnancy is a period of significant and heterogeneous behaviour change, influenced by perceptions of risk and women's lived experience. Behaviour was influenced not only by perceptions of immediate risk to the fetus, but also by the women's lived experience of being pregnant. There are exciting opportunities to constructively reframe health promotion advice relating to physical activity and diet in light of women's priorities. The need for individualized advice is highlighted, and women across all body mass index categories would

  3. Operation regimes, gain dynamics and highly stable operation points of Ho:YLF regenerative amplifiers

    CERN Document Server

    Kroetz, Peter; Calendron, Anne-Laure; Chatterjee, Gourab; Cankaya, Huseyin; Murari, Krishna; Kaertner, Franz X; Hartl, Ingmar; Miller, R J Dwayne

    2016-01-01

    We present a comprehensive study of laser pulse amplification with respect to operation regimes, gain dynamics, and highly stable operation points of Ho:YLF regenerative amplifiers (RAs). The findings are expected to be more generic than for this specific case. Operation regimes are distinguished with respect to pulse energy and the appearance of pulse instability as a function of the repetition rate, seed energy, and pump intensity. The corresponding gain dynamics are presented, identifying highly stable operation points related to high gain build -up during pumping and high gain depletion during pulse amplification. These operation points are studied numerically and experimentally as a function of several parameters, thereby achieving, for our Ho:YLF RA, highly stable output pulses with measured fluctuations of only 0.19% (standard deviation).

  4. High But Not Low Probability of Gain Elicits a Positive Feeling Leading to the Framing Effect.

    Science.gov (United States)

    Gosling, Corentin J; Moutier, Sylvain

    2017-01-01

    Human risky decision-making is known to be highly susceptible to profit-motivated responses elicited by the way in which options are framed. In fact, studies investigating the framing effect have shown that the choice between sure and risky options depends on how these options are presented. Interestingly, the probability of gain of the risky option has been highlighted as one of the main factors causing variations in susceptibility to the framing effect. However, while it has been shown that high probabilities of gain of the risky option systematically lead to framing bias, questions remain about the influence of low probabilities of gain. Therefore, the first aim of this paper was to clarify the respective roles of high and low probabilities of gain in the framing effect. Due to the difference between studies using a within- or between-subjects design, we conducted a first study investigating the respective roles of these designs. For both designs, we showed that trials with a high probability of gain led to the framing effect whereas those with a low probability did not. Second, as emotions are known to play a key role in the framing effect, we sought to determine whether they are responsible for such a debiasing effect of the low probability of gain. Our second study thus investigated the relationship between emotion and the framing effect depending on high and low probabilities. Our results revealed that positive emotion was related to risk-seeking in the loss frame, but only for trials with a high probability of gain. Taken together, these results support the interpretation that low probabilities of gain suppress the framing effect because they prevent the positive emotion of gain anticipation.

  5. High But Not Low Probability of Gain Elicits a Positive Feeling Leading to the Framing Effect

    Science.gov (United States)

    Gosling, Corentin J.; Moutier, Sylvain

    2017-01-01

    Human risky decision-making is known to be highly susceptible to profit-motivated responses elicited by the way in which options are framed. In fact, studies investigating the framing effect have shown that the choice between sure and risky options depends on how these options are presented. Interestingly, the probability of gain of the risky option has been highlighted as one of the main factors causing variations in susceptibility to the framing effect. However, while it has been shown that high probabilities of gain of the risky option systematically lead to framing bias, questions remain about the influence of low probabilities of gain. Therefore, the first aim of this paper was to clarify the respective roles of high and low probabilities of gain in the framing effect. Due to the difference between studies using a within- or between-subjects design, we conducted a first study investigating the respective roles of these designs. For both designs, we showed that trials with a high probability of gain led to the framing effect whereas those with a low probability did not. Second, as emotions are known to play a key role in the framing effect, we sought to determine whether they are responsible for such a debiasing effect of the low probability of gain. Our second study thus investigated the relationship between emotion and the framing effect depending on high and low probabilities. Our results revealed that positive emotion was related to risk-seeking in the loss frame, but only for trials with a high probability of gain. Taken together, these results support the interpretation that low probabilities of gain suppress the framing effect because they prevent the positive emotion of gain anticipation.

  6. Noise calculation model and analysis of high-gain readout circuits for CMOS image sensors

    Science.gov (United States)

    Kawahito, Shoji; Itoh, Shinya

    2008-02-01

    A thermal noise calculation model of high-gain switched-capacitor column noise cancellers for CMOS image sensors is presented. In the high-gain noise canceller with a single noise cancelling stage, the reset noise of the readout circuits dominates the noise at high gain. Using the double-stage architecture using a switched-capacitor gain stage and a sample-and-hold stage using two sampling capacitors, the reset noise of the gain stage can be cancelled. The resulting input referred thermal noise power of high-gain double-stage switched-capacitor noise canceller is revealed to be proportional to (g_a/g_s)/GC_L where g_a, G and C_L are the transconductance, gain and output capacitance of the amplifier, respectively, and g_s is the output conductance of an in-pixel source follower. An important contribution of the proposed noise calculation formula is the inclusion of the influence of the transconductance ratio of the amplifier to that of the source follower. For low-noise design, it is important that the transconductance of the amplifier used in the noise canceller is minimized under the condition of meeting the required response time of the switched capacitor amplifier which is inversely proportional to the cutoff angular frequency.

  7. Very High Gain and Low Noise Near Infrared Single Photon Counting Detectors and Arrays Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Amplification Technologies Inc ("ATI") proposes to develop the enabling material and device technology for the design of ultra low noise, high gain and low...

  8. A novel SWIR detector with an ultra-high internal gain and negligible excess noise

    Science.gov (United States)

    Mohseni, H.; Memis, O. G.; Kong, S. C.; Katsnelson, A.; Wu, W.

    2007-10-01

    Short wave infrared (SWIR) imaging systems have several advantages due to the spectral content of the nightglow and better discrimination against camouflage. Achieving single photon detection sensitivity can significantly improve the image quality of these systems. However, the internal noise of the detector and readout circuits are significant barriers to achieve this goal. One can prove that the noise limitations of the readout can be alleviated, if the detector exhibits sufficiently high internal gain. Unfortunately, the existing detectors with internal gain have a very high noise as well. Here we present the recent results from our novel FOcalized Carrier aUgmented Sensor (FOCUS). It utilizes very high charge compression into a nano-injector, and subsequent carrier injection to achieve high quantum efficiency and high sensitivity at short infrared at room temperature. We obtain internal gain values exceeding several thousand at bias values of less than 1 volt. The current responsivity at 1.55 μm is more than 1500 A/W, and the noise equivalent power (NEP) is less that 0.5 x10 -15 W/Hz 1/2 at room temperature. These are significantly better than the performance of the existing room temperature devices with internal gain. Also, unlike avalanche-based photodiodes, the measured excess noise factor for our device is near unity, even at very high gain values. The stable gain of the device combined with the low operating voltage are unique advantages of this technology for high-performance SWIR imaging arrays.

  9. Microstructure-Fibre-Based Optical Parametric Amplification in Telecom Band with Ultra-High Gain Slope

    Institute of Scientific and Technical Information of China (English)

    ZHANG Wei; XIAO Li; ZHANG Lei; HUANG Yi-Dong; PENG Jiang-De

    2006-01-01

    @@ We report a microstructure-fibre-based parametric amplification experiment in telecom band with ultra-high gain slope. A peak on-off gain of 52.3 dB is achieved using 25 m high nonlinear microstructure fibre (MF) and only 5.3 W pump power. The parametric gain slope is up to 580dBW-1 km-1. From the experimental data, the linear coefficient of the MF is estimated to be about 66. 7 W-1 km-1. The experiment shows the great potential of MFs in practical fibre parametric amplifiers.

  10. Detailed theoretical and experimental investigation of high-gain erbium-doped fiber amplifier

    DEFF Research Database (Denmark)

    Pedersen, Bo; Dybdal, Kristen; Dam-Hansen, Carsten

    1990-01-01

    A full-scale numerical model for the erbium-doped fiber amplifier has been developed that incorporates realistic index and erbium-concentration profiles as well as the spectral distribution of amplified spontaneous emission (ASE). The high accuracy of the model is demonstrated by comparison...... with a comprehensive set of data, including gain, ASE, and pump power, obtained for a well-characterized Er-Al-doped fiber. An absorption-to-emission cross-section ratio of 1.0 was measured at the gain peak. Pumping at 654 nm, the excited state absorption was observed to be insignificant. A high gain of 39.6 d...

  11. High-Gain AlxGa1-xAs/GaAs Transistors For Neural Networks

    Science.gov (United States)

    Kim, Jae-Hoon; Lin, Steven H.

    1991-01-01

    High-gain AlxGa1-xAs/GaAs npn double heterojunction bipolar transistors developed for use as phototransistors in optoelectronic integrated circuits, especially in artificial neural networks. Transistors perform both photodetection and saturating-amplification functions of neurons. Good candidates for such application because structurally compatible with laser diodes and light-emitting diodes, detect light, and provide high current gain needed to compensate for losses in holographic optical elements.

  12. Telmisartan prevents weight gain and obesity through activation of peroxisome proliferator-activated receptor-delta-dependent pathways

    DEFF Research Database (Denmark)

    He, Hongbo; Yang, Dachun; Ma, Liqun

    2010-01-01

    Telmisartan shows antihypertensive and several pleiotropic effects that interact with metabolic pathways. In the present study we tested the hypothesis that telmisartan prevents adipogenesis in vitro and weight gain in vivo through activation of peroxisome proliferator-activated receptor (PPAR......)-delta-dependent pathways in several tissues. In vitro, telmisartan significantly upregulated PPAR-delta expression in 3T3-L1 preadipocytes in a time- and dose-dependent manner. Other than enhancing PPAR-delta expression by 68.2+/-17.3% and PPAR-delta activity by 102.0+/-9.0%, telmisartan also upregulated PPAR......-gamma expression, whereas neither candesartan nor losartan affected PPAR-delta expression. In vivo, long-term administration of telmisartan significantly reduced visceral fat and prevented high-fat diet-induced obesity in wild-type mice and hypertensive rats but not in PPAR-delta knockout mice. Administration...

  13. Gain and loss enhancement in active and passive particulate composite materials

    CERN Document Server

    Mackay, Tom G

    2015-01-01

    Two active dielectric materials may be blended together to realize a homogenized composite material (HCM) which exhibits more gain than either component material. Likewise, two dissipative dielectric materials may be blended together to realize an HCM which exhibits more loss than either component material. Sufficient conditions for such gain/loss enhancement were established using the Bruggeman homogenization formalism. Gain/loss enhancement arises when (i) the imaginary parts of the relative permittivities of both component materials are similar in magnitude and (ii) the real parts of the relative permittivities of both component materials are dissimilar in magnitude.

  14. Polarization-insensitive optical gain characteristics of highly stacked InAs/GaAs quantum dots

    Energy Technology Data Exchange (ETDEWEB)

    Kita, Takashi; Suwa, Masaya; Kaizu, Toshiyuki; Harada, Yukihiro [Department of Electrical and Electronic Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501 (Japan)

    2014-06-21

    The polarized optical gain characteristics of highly stacked InAs/GaAs quantum dots (QDs) with a thin spacer layer fabricated on an n{sup +}-GaAs (001) substrate were studied in the sub-threshold gain region. Using a 4.0-nm-thick spacer layer, we realized an electronically coupled QD superlattice structure along the stacking direction, which enabled the enhancement of the optical gain of the [001] transverse-magnetic (TM) polarization component. We systematically studied the polarized electroluminescence properties of laser devices containing 30 and 40 stacked InAs/GaAs QDs. The net modal gain was analyzed using the Hakki-Paoli method. Owing to the in-plane shape anisotropy of QDs, the polarization sensitivity of the gain depends on the waveguide direction. The gain showing polarization isotropy between the TM and transverse-electric polarization components is high for the [110] waveguide structure, which occurs for higher amounts of stacked QDs. Conversely, the isotropy of the [−110] waveguide is easily achieved even if the stacking is relatively low, although the gain is small.

  15. Optical Amplifier with Flat-Gain and Wideband Operation Utilizing Highly Concentrated Erbium-Doped Fibers

    Science.gov (United States)

    Hamida, B. A.; Cheng, X. S.; Naji, A. W.; Ahmad, H.; Al-Khateeb, W.; Khan, S.; Harun, S. W.

    In this paper, we proposed a flat-gain and wide-band erbium doped fiber amplifier (EDFA) using two chirped fiber Bragg grating (CFBG) in serial configuration for double-pass operation. The amplifier consists of two sections of Erbium-doped fiber (EDF) operating in C-band and L-band respectively. A CFBG is used in each section to reflect the amplified signal back to the active area so that the overall gain spectrum can be enhanced and flattened. It is also observed that the gain of the amplifier produces a relatively higher gain with the Bismuth-based EDF (Bi-EDF) in the first stage compared to that of silica-based EDF (Si-EDF), especially in a longer wavelength region. The small signal gain of more than 19 dB is obtained within a wavelength region from 1545 to 1605 nm by the use of Bi-EDF with a small noise figure penalty. With a Si-EDF, the flat gain spectrum is observed within a wavelength region ranging from 1535 nm to 1605 nm with a gain variation of less than 2 dB at input signal of 0 dBm. This shows that the proposed serial double-pass amplifier may find its broad applications in wavelength division multiplexing long-haul systems as well as local optical networks.

  16. DEMONSTRATION OF 3D EFFECTS WITH HIGH GAIN AND EFFICIENCY IN A UV FEL OSCILLATOR

    Energy Technology Data Exchange (ETDEWEB)

    Stephen Benson; George Biallas; Keith Blackburn; James Boyce; Donald Bullard; James Coleman; Cody Dickover; David Douglas; Forrest Ellingsworth; Pavel Evtushenko; Carlos Hernandez-Garcia; Christopher Gould; Joseph Gubeli; David Hardy; Kevin Jordan; John Klopf; James Kortze; Robert Legg; Matthew Marchlik; Steven Moore; George Neil; Thomas Powers; Daniel Sexton; Michelle D. Shinn; Christopher Tennant; Richard Walker; Anne Watson; Gwyn Williams; Frederick Wilson; Shukui Zhang

    2011-03-01

    We report on the performance of a high gain UV FEL oscillator operating on an energy recovery linac at Jefferson Lab. The high brightness of the electron beam leads to both gain and efficiency that cannot be reconciled with a one-dimensional model. Three-dimensional simulations do predict the performance with reasonable precision. Gain in excess of 100% per pass and an efficiency close to 1/2NW, where NW is the number of wiggler periods, is seen. The laser mirror tuning curves currently permit operation in the wavelength range of 438 to 362 nm. Another mirror set allows operation at longer wavelengths in the red with even higher gain and efficiency.

  17. Utilizing wideband AMC structures for high-gain inkjet-printed antennas on lossy paper substrate

    KAUST Repository

    Cook, Benjamin Stassen

    2013-01-01

    Significant gain and bandwidth improvement of inkjet-printed antennas with integrated artificial magnetic conductor (AMC) is achieved by utilizing wideband ground-backed frequency selective surfaces (FSSs) to overcome the high losses of organic substrates such as paper. A microstrip-fed monopole mounted on an artificial magnetic conductor is demonstrated to improve the gain by 5 dB over previous works and exhibit much wider impedance bandwidth while maintaining a thin antenna profile and a 20% electrical size reduction. The effect of AMC bandwidth on substrate losses and the gain reduction caused by finite AMC array effects are investigated in an effort to produce high-gain, miniaturized, low-cost wearable and structure mount antennas. © 2013 IEEE.

  18. 3-D numerical analysis of a high-gain free-electron laser

    Energy Technology Data Exchange (ETDEWEB)

    Gallardo, J.C.

    1988-10-19

    We present a novel approach to the 3-dimensional high-gain free- electron laser amplifier problem. The method allows us to write the laser field as an integral equation which can be efficiently and accurately evaluated on a small computer. The model is general enough to allow the inclusion of various initial electron beam distributions to study the gain reduction mechanism and its dependence on the physical parameters. 16 refs., 8 figs., 1 tab.

  19. Modeling of gain saturation effects in active semiconductor photonic crystal waveguides

    DEFF Research Database (Denmark)

    Chen, Yaohui; Mørk, Jesper

    2012-01-01

    In this paper, we present a theoretical analysis of slow-light enhanced light amplification in an active semiconductor photonic crystal line defect waveguide. The impact of enhanced light-matter interactions on carrier-depletion-induced modal gain saturation is investigated.......In this paper, we present a theoretical analysis of slow-light enhanced light amplification in an active semiconductor photonic crystal line defect waveguide. The impact of enhanced light-matter interactions on carrier-depletion-induced modal gain saturation is investigated....

  20. Shock-Ignited High Gain/Yield Targets for the National Ignition Facility

    Science.gov (United States)

    Perkins, L. J.; Lafortune, K. N.; Bedrosiian, P.; Tabak, M.; Miles, A.; Dixit, S.; Betti, R.; Anderson, K.; Zhou, C.

    2006-10-01

    Shock-ignition, a new concept for ICF ignition [C.Zhou, R.Betti Bull APS, v50, 2005], is being studied as a future option for efficiently achieving high gains in large laser facilities such as NIF. Accordingly, this offers the potential for testing: (1)High yield (up to 200MJ), reactor-relevant targets for inertial fusion energy (2)High fusion yield targets for DOE NNSA stockpile application (3)Targets with appreciable gain at low laser drive energies (gains of 10's at 150kJ) (4)Ignition of simple, non-cryo (room temperature) single shell gas targets at (unity gain). By contrast to conventional hotspot ignition, we separate the assembly and ignition phases by initially imploding a massive cryogenic shell on a low adiabat (alpha 0.7) at low velocity (less than 2e7cm/s) using a direct drive pulse of modest total energy. The assembled fuel is then separately ignited by a strong, spherically convergent shock driven by a high intensity spike at the end of the pulse and timed to reach the center as the main fuel is stagnating and starting to rebound. Like fast ignition, shock ignition can achieve high gains with low drive energy, but has the advantages of requiring only a single laser with less demanding timing and spatial focusing requirements.

  1. Performance Analysis of Low Power, High Gain Operational Amplifier Using CMOS VLSI Design

    Directory of Open Access Journals (Sweden)

    Ankush S. Patharkar

    2014-07-01

    Full Text Available The operational amplifier is one of the most useful and important component of analog electronics. They are widely used in popular electronics. Their primary limitation is that they are not especially fast. The typical performance degrades rapidly for frequencies greater than about 1 MHz, although some models are designed specifically to handle higher frequencies. The primary use of op-amps in amplifier and related circuits is closely connected to the concept of negative feedback. The operational amplifier has high gain, high input impedance and low output impedance. Here the operational amplifier designed by using CMOS VLSI technology having low power consumption and high gain.

  2. Impact of gain saturation on the mode instability threshold in high-power fiber amplifiers

    DEFF Research Database (Denmark)

    Hansen, Kristian Rymann; Lægsgaard, Jesper

    2014-01-01

    We present a coupled-mode model of transverse mode instability in high-power fiber amplifiers, which takes the effect of gain saturation into account. The model provides simple semi-analytical formulas for the mode instability threshold, which are valid also for highly saturated amplifiers...

  3. Steady State Analysis of Short-wavelength, High-gainFELs in a Large Storage Ring

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Z.; Bane, K.; Cai, Y.; Chao, A.; Hettel, R.; /SLAC; Pellegrini, C.; /UCLA

    2007-10-15

    Storage ring FELs have operated successfully in the low-gain regime using optical cavities. Discussions of a high-gain FEL in a storage ring typically involve a special bypass to decouple the FEL interaction from the storage ring dynamics. In this paper, we investigate the coupled dynamics of a high-gain FEL in a large storage ring such as PEP and analyze the equilibrium solution. We show that an FEL in the EUV and soft x-ray regimes can be integrated into a very bright storage ring and potentially provides three orders of magnitude improvement in the average brightness at these radiation wavelengths. We also discuss possibilities of seeding with HHG sources to obtain ultra-short, high-peak power EUV and soft x-ray pulses.

  4. High-gain X-ray free electron laser by beat-wave terahertz undulator

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Chao; Hei, DongWei [Science and Technology on High Power Microwave Laboratory, Northwest Institute of Nuclear Technology, Xi' an City 710024 (China); Institute of Energy, Tsinghua University, Beijing 100084 (China); Pellegrin, Claudio; Tantawi, Sami [SLAC National Accelerator Laboratory, Stanford University, Stanford, California 94309 (United States)

    2013-12-15

    The THz undulator has a higher gain to realize a much brighter X-ray at saturation, compared with the optical undulator under the same undulator strength and beam quality. In order to fill the high-power THz gap and realize the THz undulator, two superimposed laser pulses at normal incidence to the electron-beam moving direction form an equivalent high-field THz undulator by the frequency difference to realize the high-gain X-ray Free electron laser. The pulse front tilt of lateral fed lasers is used to realize the electron-laser synchronic interaction. By PIC simulation, a higher gain and a larger X-ray radiation power by the beat wave THz undulator could be realized, compared with the optical undulator for the same electron beam parameters.

  5. Development of low read noise high conversion gain CMOS image sensor for photon counting level imaging

    Science.gov (United States)

    Seo, Min-Woong; Kawahito, Shoji; Kagawa, Keiichiro; Yasutomi, Keita

    2016-05-01

    A CMOS image sensor with deep sub-electron read noise and high pixel conversion gain has been developed. Its performance is recognized through image outputs from an area image sensor, confirming the capability of photoelectroncounting- level imaging. To achieve high conversion gain, the proposed pixel has special structures to reduce the parasitic capacitances around FD node. As a result, the pixel conversion gain is increased due to the optimized FD node capacitance, and the noise performance is also improved by removing two noise sources from power supply. For the first time, high contrast images from the reset-gate-less CMOS image sensor, with less than 0.3e- rms noise level, have been generated at an extremely low light level of a few electrons per pixel. In addition, the photon-counting capability of the developed CMOS imager is demonstrated by a measurement, photoelectron-counting histogram (PCH).

  6. Exact and variational solutions of 3D eigenmodes in high gain FELs [Exact and variational solutions of 3D eigenmodes in high gain free electron lasers

    Energy Technology Data Exchange (ETDEWEB)

    Xie, Ming [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2000-05-18

    Exact solution and variational approximation of eigenmodes in high gain FELs are presented. These eigenmodes specify transverse profiles and exponential growth rates of the laser field before saturation. They are self-consistent solutions of coupled Maxwell–Vlasov equations describing FEL interaction taking into account the effects due to energy spread, emittance and betatron oscillations of the electron beam, as well as diffraction and optical guiding of the laser field. A new formalism of scaling is introduced and based on which solutions in various limiting cases are discussed. Additionally, a fitting formula is obtained from interpolating the variational solution for quick calculation of exponential growth rate of the fundamental mode.

  7. Gain optimization in fiber optical parametric amplifiers by combining standard and high-SBS threshold highly nonlinear fibers

    DEFF Research Database (Denmark)

    Da Ros, Francesco; Rottwitt, Karsten; Peucheret, Christophe

    2012-01-01

    Combining Al-doped and Ge-doped HNLFs as gain media in FOPAs is proposed and optimized, resulting in efficient SBS mitigation while circumventing the additional loss of the high SBS threshold Al-doped fiber.......Combining Al-doped and Ge-doped HNLFs as gain media in FOPAs is proposed and optimized, resulting in efficient SBS mitigation while circumventing the additional loss of the high SBS threshold Al-doped fiber....

  8. High-Directional Wave Propagation in Periodic Gain/Loss Modulated Materials

    CERN Document Server

    Kumar, N; Herrero, R; Loiko, Yu; Staliunas, K

    2012-01-01

    Amplification/attenuation of light waves in artificial materials with a gain/loss modulation on the wavelength scale can be sensitive to the propagation direction. We give a numerical proof of the high anisotropy of the gain/loss in two dimensional periodic structures with square and rhombic lattice symmetry by solving the full set of Maxwell's equations using the finite difference time domain method. Anisotropy of amplification/attenuation leads to the narrowing of the angular spectrum of propagating radiation with wavevectors close to the edges of the first Brillouin Zone. The effect provides a novel and useful method to filter out high spatial harmonics from noisy beams.

  9. A Broadband and High Gain Tapered Slot Antenna for W-Band Imaging Array Applications

    Directory of Open Access Journals (Sweden)

    Dong Sik Woo

    2014-01-01

    Full Text Available A broadband and high gain tapered slot antenna (TSA by utilizing a broadband microstrip- (MS- to-coplanar stripline (CPS balun has been developed for millimeter-wave imaging systems and sensors. This antenna exhibits ultrawideband performance for frequency ranges from 70 to over 110 GHz with the high antenna gain, low sidelobe levels, and narrow beamwidth. The validity of this antenna as imaging arrays is also demonstrated by analyzing mutual couplings and 4-element linear array. This antenna can be applied to mm-wave phased array, imaging array for plasma diagnostics applications.

  10. Adaptive control of linear multivariable systems with high frequency gain matrix hurwitz

    Institute of Scientific and Technical Information of China (English)

    Ying ZHOU; Yuqiang WU; Shumin FEI

    2005-01-01

    A new adaptive control scheme is proposed for multivariable model reference adaptive control(MRAC) systems based on the nonlinear backstepping approach with vector form.The assumption on a priori knowledge of the high frequency gain matrix in existing results is relaxed and the new required condition for the high frequency gain matrix can be easily checked for certain plants so that the proposed method is widely applicable.This control scheme guarantees the global stability of the closed-loop systems and the tracking error can be arbitrary small.The simulation result for an application example shows the validity of the proposed nonlinear adaptive scheme.

  11. Very high-accuracy calibration of radiation pattern and gain of a near-field probe

    DEFF Research Database (Denmark)

    Pivnenko, Sergey; Nielsen, Jeppe Majlund; Breinbjerg, Olav

    2014-01-01

    In this paper, very high-accuracy calibration of the radiation pattern and gain of a near-field probe is described. An open-ended waveguide near-field probe has been used in a recent measurement of the C-band Synthetic Aperture Radar (SAR) Antenna Subsystem for the Sentinel 1 mission of the Europ......In this paper, very high-accuracy calibration of the radiation pattern and gain of a near-field probe is described. An open-ended waveguide near-field probe has been used in a recent measurement of the C-band Synthetic Aperture Radar (SAR) Antenna Subsystem for the Sentinel 1 mission...

  12. 78 FR 74125 - Agency Information Collection Activities; Comment Request; Measuring Educational Gain in the...

    Science.gov (United States)

    2013-12-10

    ... Agency Information Collection Activities; Comment Request; Measuring Educational Gain in the National.... chapter 3501 et seq.), ED is proposing an extension of an existing information collection. DATES... submitted after the comment period will not be accepted. Written requests for information or...

  13. Inkjet Printing of Paper-Based Wideband and High Gain Antennas

    KAUST Repository

    Cook, Benjamin

    2011-12-07

    This thesis represents a major contribution to wideband and high gain inkjet-printed antennas on paper. This work includes the complete characterization of the inkjet printing process for passive microwave devices on paper substrate as well as several ultra-wideband and high gain antenna designs. The characterization work includes the electrical characterization of the permittivity and loss tangent for paper substrate through 10 GHz, ink conductivity data for variable sintering conditions, and minimum feature sizes obtainable by today’s current inkjet processes for metallic nanoparticles. For the first time ever, inkjet-printed antennas are demonstrated that operate over the entire UWB band and demonstrate gains up to 8dB. This work also presents the first fractal-based inkjet-printed antennas with enhanced bandwidth and reduced production costs, and a novel slow wave log periodic dipole array which shows minimizations of 20% in width over conventional log periodic antennas.

  14. Improvement on a 2 × 2 Elements High-Gain Circularly Polarized Antenna Array

    Directory of Open Access Journals (Sweden)

    C. Liu

    2015-01-01

    Full Text Available A novel antipodal Vivaldi antenna with tapering serrated structure at the edges is proposed. Compared with traditional Vivaldi antennas without serrated structure, the gain of the designed antenna is significantly improved in the desired frequency band (4.5–7.5 GHz. In addition, a 2 × 2 Vivaldi antenna array with an orthorhombic structure is designed and fabricated to achieve a circular polarization (CP characteristic. With this configuration, the 3 dB axial ratio bandwidth of the array reaches about 42% with respect to the center frequency of 6 GHz and a high gain is achieved as well. The novel Vivaldi antenna and CP antenna array both have ultrawide band (UWB and high-gain characteristics, which may be applied to the field of commercial communication, remote sensing, and so forth.

  15. Dynamic properties of a pulse-pumped fiber laser with a short, high-gain cavity

    Science.gov (United States)

    Yang, Chaolin; Guo, Junhong; Wei, Pu; Wan, Hongdan; Xu, Ji; Wang, Jin

    2016-09-01

    We demonstrate a pulsed high-gain all-fiber laser without intracavity modulators, where a short and heavily Erbium-doped fiber is used as the gain medium in a ring cavity. By pulsed-pumping this short high gain cavity and tuning an intracavity variable optical coupler, the laser generates optical pulses with a pulse-width of μs at a repetition rate in the order of kHz down to one-shot operation. Furthermore, dynamic properties of this laser are investigated theoretically based on a traveling-wave-model, in which an adaptive-discrete-grid-finite-difference-method is applied. The simulation results validate the experimental results. The demonstrated pulsed laser is compact, flexible and cost-effective, which will have great potential for applications in all-optical sensing and communication systems.

  16. Enhancing speed of pinning synchronizability: low-degree nodes with high feedback gains

    CERN Document Server

    Zhou, Ming-Yang; Liao, Hao; Fu, Zhong-Qian; Cai, Shi-Min

    2015-01-01

    Controlling complex networks is of paramount importance in science and engineering. Despite recent efforts to improve controllability and synchronous strength, little attention has been paid to the speed of pinning synchronizability (rate of convergence in pinning control) and the corresponding pinning node selection. To address this issue, we propose a hypothesis to restrict the control cost, then build a linear matrix inequality related to the speed of pinning controllability. By solving the inequality, we obtain both the speed of pinning controllability and optimal control strength (feedback gains in pinning control) for all nodes. Interestingly, some low-degree nodes are able to achieve large feedback gains, which suggests that they have high influence on controlling system. In addition, when choosing nodes with high feedback gains as pinning nodes, the controlling speed of real systems is remarkably enhanced compared to that of traditional large-degree and large-betweenness selections. Thus, the proposed...

  17. Enhanced optical precursors by Doppler effect via active Raman gain process.

    Science.gov (United States)

    Peng, Yandong; Niu, Yueping; Zhang, Lida; Yang, Aihong; Jiang, Lin; Gong, Shangqing

    2012-08-15

    A scheme for enhancing precursor pulse by Doppler effect is proposed in a room-temperature active-Raman-gain medium. Due to abnormal dispersion between two gain peaks, main fields are advanced and constructively interfere with optical precursors, which leads to enhancement of the transient pulse at the rise edge of the input. Moreover, after Doppler averaging, the abnormal dispersion intensifies and the constructive interference between precursors and main fields is much strengthened, which boosts the transient spike. Simulation results demonstrate that the peak intensity of precursors could be enhanced nearly 20 times larger than that of the input.

  18. Shock Ignition: A New Approach to High Gain Targets for the National Ignition Facility

    Science.gov (United States)

    Perkins, L. John; Lafortune, Kai; Divol, Laurent; Betti, Riccardo

    2008-11-01

    Shock-ignition is being studied as a future option for achieving high target gains on NIF, offering the potential for testing high yield (200MJ), reactor-relevant targets for inertial fusion energy and targets with appreciable gains at drive energies much less than 1MJ. In contrast to conventional hotspot ignition, the assembly and ignition phases are separated by imploding a high mass shell at low velocity. The assembled fuel is then separately ignited by a strong, spherical shock driven by a high intensity spike at the end of the pulse and timed to reach the center as the main fuel is stagnating. Because the implosion velocity is significantly less than that required for hotspot ignition, considerably more fuel mass can be assembled and burned for the same kinetic energy in the shell. Like fast ignition, shock ignition could achieve high gains at low drive energy, but has the advantages of requiring only a single laser with less demanding timing and spatial focusing requirements. We will discuss gain curves for shock-ignited NIF targets in both UV and green light and examine the feasibility of designs that employ indirect drive fuel assembly with direct drive shock ignition

  19. Aquatic Activities During Pregnancy Prevent Excessive Maternal Weight Gain and Preserve Birth Weight.

    Science.gov (United States)

    Bacchi, Mariano; Mottola, Michelle F; Perales, Maria; Refoyo, Ignacio; Barakat, Ruben

    2017-01-01

    The aim of the present study was to examine the influence of a supervised and regular program of aquatic activities throughout gestation on maternal weight gain and birth weight. A randomized clinical trial. Instituto de Obstetricia, Ginecología y Fertilidad Ghisoni (Buenos Aires, Argentina). One hundred eleven pregnant women were analyzed (31.6 ± 3.8 years). All women had uncomplicated and singleton pregnancies; 49 were allocated to the exercise group (EG) and 62 to the control group (CG). The intervention program consisted of 3 weekly sessions of aerobic and resistance aquatic activities from weeks 10 to 12 until weeks 38 to 39 of gestation. Maternal weight gain, birth weight, and other maternal and fetal outcomes were obtained by hospital records. Student unpaired t test and χ(2) test were used; P values ≤.05 indicated statistical significance. Cohen's d was used to determinate the effect size. There was a higher percentage of women with excessive maternal weight gain in the CG (45.2%; n = 28) than in the EG (24.5%; n = 12; odds ratio = 0.39; 95% confidence interval: 0.17-0.89; P = .02). Birth weight and other pregnancy outcomes showed no differences between groups. Three weekly sessions of water activities throughout pregnancy prevents excessive maternal weight gain and preserves birth weight. The clinicaltrial.gov identifier: NCT 02602106.

  20. 75 FR 61228 - Board Meeting: Technical Lessons Gained From High-Level Nuclear Waste Disposal Efforts

    Science.gov (United States)

    2010-10-04

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR WASTE TECHNICAL REVIEW BOARD Board Meeting: Technical Lessons Gained From High-Level Nuclear Waste Disposal Efforts Pursuant to its authority under section 5051 of Public Law 100-203, Nuclear Waste Policy Amendments Act...

  1. Femtosecond Ti:sapphire cryogenic amplifier with high gain and MHz repetition rate

    DEFF Research Database (Denmark)

    Dantan, Aurelien Romain; Laurat, Julien; Ourjoumtsev, Alexei

    2007-01-01

    We demonstrate high gain amplification of 160-femtosecond pulses in a compact double-pass cryogenic Ti:sapphire amplifier. The setup involves a negative GVD mirrors recompression stage, and operates with a repetition rate between 0.2 and 4 MHz with a continuous pump laser. Amplification factors...

  2. Review on High Gain Conical Horn Antenna for Short-Range Communications

    Directory of Open Access Journals (Sweden)

    Priyanka Bhagwat

    2013-11-01

    Full Text Available Horn antennas are very popular at UHF (300 MHz-3 GHz and higher frequencies ( as high as 140 GHz. Horn antennas often have a directional radiation pattern with a high antenna gain, which can range up to 25 dB in some cases, with 10-20 dB being typical. Horn antennas have a wide impedance bandwidth, implying that the input impedance is slowly varying over a wide frequency range. The bandwidth for practical horn antennas can be of the order of 20:1 (for instance, operating from 1 GHz-20 GHz, with a 10:1 bandwidth being common. The gain of horn antennas often increases as the frequency of operation is increased. This is because the size of the horn aperture is measured in wavelengths; at higher frequencies the horn antenna is "electrically larger" because high frequency has a smaller wavelength. Horn antennas have very little loss, so the directivity of a horn is roughly equal to its gain. In this paper, we will present review about conical horn antenna which uses hybrid technique and provides high gain at frequencies ranging 3GHz keeping its size within limits. Also, literature survey will demostrate other reference papers will includes horn antennas using different techniques and used for various applications.

  3. Magnetically coupled high-gain Y-source isolated DC/DC converter

    DEFF Research Database (Denmark)

    Siwakoti, Yam P.; Loh, Poh Chiang; Blaabjerg, Frede

    2014-01-01

    A new form of magnetically coupled DC/DC converter is proposed for medium power applications (250 W to 2 kW), requiring a high-voltage gain, short inductive charging time and galvanic isolation. The proposed converter can be realised using a unique Y-source impedance network and a two-switch push...

  4. A high voltage gain quasi Z-source isolated DC/DC converter

    DEFF Research Database (Denmark)

    Siwakoti, Yam P.; Blaabjerg, Frede; Loh, Poh Chiang

    2014-01-01

    A compact quasi-Z-source DC/DC converter is presented with high voltage gain, isolated output, and improved efficiency. The improvements in size and performance were achieved by using a square wave inverter with only two output switches driving an isolating transformer in push-pull mode, followed...

  5. Convergent evolution towards high net carbon gain efficiency contributes to the shade tolerance of palms (Arecaceae)

    NARCIS (Netherlands)

    Ma, Ren Yi; Zhang, Jiao Lin; Cavaleri, Molly A.; Sterck, Frank; Strijk, J.S.; Cao, Kun Fang

    2015-01-01

    Most palm species occur in the shaded lower strata of tropical rain forests, but how their traits relate to shade adaptation is poorly understood. We hypothesized that palms are adapted to the shade of their native habitats by convergent evolution towards high net carbon gain efficiency (CGEn),

  6. Resistance and susceptibility to weight gain: individual variability in response to a high-fat diet.

    Science.gov (United States)

    Blundell, J E; Stubbs, R J; Golding, C; Croden, F; Alam, R; Whybrow, S; Le Noury, J; Lawton, C L

    2005-12-15

    An obesigenic environment is a potent force for promoting weight gain. However, not all people exposed to such an environment become obese; some remain lean. This means that some people are susceptible to weight gain (in a weight-promoting environment) and others are resistant. Identifying the characteristics of appetite control and food motivation in these two groups could throw light on the causes of weight gain and how this can be either treated or prevented. We have investigated the issue experimentally by identifying people who habitually consume a high-fat diet (greater than 43% fat energy). These individuals have been termed high-fat phenotypes. We have compared individuals, of the same age (mean=37 years old) and gender (male), who have gained weight (BMI=34) or who have remained lean (BMI=22). The susceptible individuals are characterised by a cluster of characteristics including a weak satiety response to fatty meals, a maintained preference for high-fat over low-energy foods in the post-ingestive satiety period, a strong hedonic attraction to palatable foods and to eating, and high scores on the TFEQ factors of Disinhibition and Hunger. The analysis of large databases suggests that this profile of factors contributes to an average daily positive energy balance from food of approximately 0.5 MJ. This profile of characteristics helps to define the symptomatology of a thrifty phenotype.

  7. High-Current Gain Two-Dimensional MoS 2 -Base Hot-Electron Transistors

    KAUST Repository

    Torres, Carlos M.

    2015-12-09

    The vertical transport of nonequilibrium charge carriers through semiconductor heterostructures has led to milestones in electronics with the development of the hot-electron transistor. Recently, significant advances have been made with atomically sharp heterostructures implementing various two-dimensional materials. Although graphene-base hot-electron transistors show great promise for electronic switching at high frequencies, they are limited by their low current gain. Here we show that, by choosing MoS2 and HfO2 for the filter barrier interface and using a noncrystalline semiconductor such as ITO for the collector, we can achieve an unprecedentedly high-current gain (α ∼ 0.95) in our hot-electron transistors operating at room temperature. Furthermore, the current gain can be tuned over 2 orders of magnitude with the collector-base voltage albeit this feature currently presents a drawback in the transistor performance metrics such as poor output resistance and poor intrinsic voltage gain. We anticipate our transistors will pave the way toward the realization of novel flexible 2D material-based high-density, low-energy, and high-frequency hot-carrier electronic applications. © 2015 American Chemical Society.

  8. Prior exercise training blunts short-term high-fat diet-induced weight gain.

    Science.gov (United States)

    Snook, Laelie A; MacPherson, Rebecca E K; Monaco, Cynthia M F; Frendo-Cumbo, Scott; Castellani, Laura; Peppler, Willem T; Anderson, Zachary G; Buzelle, Samyra L; LeBlanc, Paul J; Holloway, Graham P; Wright, David C

    2016-08-01

    High-fat diets rapidly cause weight gain and glucose intolerance. We sought to determine whether these changes could be mitigated with prior exercise training. Male C57BL/6J mice were exercise-trained by treadmill running (1 h/day, 5 days/wk) for 4 wk. Twenty-four hours after the final bout of exercise, mice were provided with a high-fat diet (HFD; 60% kcal from lard) for 4 days, with no further exercise. In mice fed the HFD prior to exercise training, the results were blunted weight gain, reduced fat mass, and a slight attenuation in glucose intolerance that was mirrored by greater insulin-induced Akt phosphorylation in skeletal muscle compared with sedentary mice fed the HFD. When ad libitum-fed sedentary mice were compared with sedentary high-fat fed mice that were calorie restricted (-30%) to match the weight gain of the previously trained high-fat fed mice, the same attenuated impairments in glucose tolerance were found. Blunted weight gain was associated with a greater capacity to increase energy expenditure in trained compared with sedentary mice when challenged with a HFD. Although mitochondrial enzymes in white adipose tissue and UCP-1 protein content in brown adipose tissue were increased in previously exercised compared with sedentary mice fed a HFD, ex vivo mitochondrial respiration was not increased in either tissue. Our data suggest that prior exercise training attenuates high-fat diet-induced weight gain and glucose intolerance and is associated with a greater ability to increase energy expenditure in response to a high-fat diet.

  9. Design on X-band Wideband and High-gain Multi-layer Microstrip Antenna

    Directory of Open Access Journals (Sweden)

    Soufian LAKRIT

    2014-07-01

    Full Text Available In this paper, a wide-band and high-gain microstrip antenna with mullti-layer microstrip patch and an aperture-coupled feeding is proposed. The antenna has a condensed structure where the dimension is about 8.5mm by 7.5mm by 4.662mm leading to good bandwidths covering 8.05 GHz to 12.01 GHz (39.48%, and the gain is up to 5.23dB. The low expenses of this profile and its simple configuration allows for an its easy fabrication, with appropriation with wireless and satellite communication.

  10. Design on X-band Wideband and High-gain Multi-layer Microstrip Antenna

    OpenAIRE

    Soufian LAKRIT; Hassan AMMOR

    2014-01-01

    In this paper, a wide-band and high-gain microstrip antenna with mullti-layer microstrip patch and an aperture-coupled feeding is proposed. The antenna has a condensed structure where the dimension is about 8.5mm by 7.5mm by 4.662mm leading to good bandwidths covering 8.05 GHz to 12.01 GHz (39.48%), and the gain is up to 5.23dB. The low expenses of this profile and its simple configuration allows for an its easy fabrication, with appropriation with wireless and satellite communica...

  11. High-precision gas gain and energy transfer measurements in Ar–CO{sub 2} mixtures

    Energy Technology Data Exchange (ETDEWEB)

    Şahin, Özkan, E-mail: osahin@uludag.edu.tr [Department of Physics, Uludağ University, 16059 Bursa (Turkey); Kowalski, Tadeusz Z. [Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Kraków (Poland); Veenhof, Rob [Department of Physics, Uludağ University, 16059 Bursa (Turkey); RD51 collaboration, CERN, Genève (Switzerland)

    2014-12-21

    Ar–CO{sub 2} is a Penning mixture since a fraction of the energy stored in Ar 3p{sup 5}3d and higher excited states can be transferred to ionize CO{sub 2} molecules. In the present work, concentration and pressure dependence of Penning transfer rate and photon feedback parameter in Ar–CO{sub 2} mixtures have been investigated with recent systematic high-precision gas gain measurements which cover the range 1–50% CO{sub 2} at 400, 800, 1200, 1800 hPa and gas gain from 1 to 5×10{sup 5}.

  12. High-precision gas gain and energy transfer measurements in Ar–CO2 mixtures

    CERN Document Server

    Şahin, Özkan; Veenhof, Rob

    2014-01-01

    Ar–CO2 is a Penning mixture since a fraction of the energy stored in Ar 3p53d3p53d and higher excited states can be transferred to ionize CO2 molecules. In the present work, concentration and pressure dependence of Penning transfer rate and photon feedback parameter in Ar–CO2 mixtures have been investigated with recent systematic high-precision gas gain measurements which cover the range 1–50% CO2 at 400, 800, 1200, 1800 hPa and gas gain from 1 to 5×105.

  13. Factors influencing individual variability in high fat diet-induced weight gain in out-bred MF1 mice.

    Science.gov (United States)

    Vaanholt, L M; Sinclair, R E; Mitchell, S E; Speakman, J R

    2015-05-15

    Easy access to high-energy palatable foods has been suggested to have contributed to the world-wide obesity epidemic. However, within these 'obesogenic' environments many people manage to remain lean. Mice also show variability in their weight gain responses to high-fat diet (HFD) feeding and their weight loss responses to calorically restricted (CR) feeding. In this study we investigated which factors contribute to determining susceptibility to HFD-induced obesity in mice, and whether the responses in weight gain on HFD are correlated with the responses to CR. One-hundred twenty four mice were exposed to 30% CR for 28days followed by a 14day recovery period, and subsequent exposure to 60% HFD for 28days. Responses in various metabolic factors were measured before and after each exposure (body mass; BM, body composition, food intake; FI, resting metabolic rate; RMR, physical activity, body temperature and glucose tolerance; GT). Weight changes on HFD ranged from -1 to 26%, equivalent to -0.2g to 10.5g in absolute mass. Multiple regression models showed that fat free mass (FFM) of the mice before exposure to HFD predicted 12% of the variability in weight gain on HFD (pweight gain. Weight gain on the HFD was significantly negatively correlated to weight loss on CR, indicating that animals that are poor at defending against weight gain on HFD, were also poor at defending against CR-induced weight loss. Changes in FM and FFM in response to HFD or CR were not correlated however. Copyright © 2015 Elsevier Inc. All rights reserved.

  14. Quantum limited noise figure operation of high gain erbium doped fiber amplifiers

    DEFF Research Database (Denmark)

    Lumholt, Ole; Povlsen, Jørn Hedegaard; Schüsler, Kim;

    1993-01-01

    powers below -5 dBm, and an improvement of 2.0 dB with a simultaneous gain increase of 4.1 dB is measured relative to a gain-optimized fiber. The optimum isolator location is evaluated for different pump and signal wavelengths in both an Al/Er-doped and a Ge/Er-doped fiber, for pump and signal power......Performance improvements obtained by using an isolator as an amplified-spontaneous-emission-suppressing component within erbium-doped fibers are evaluated. Simultaneous high-gain and near-quantum-limited noise figures can be obtained by such a scheme. The noise figure improves for input signal...... variations and different pump configurations. In all cases the optimum isolator position lies within 10-37% of the total fiber length for small signal operation...

  15. Millimeter Wave Fabry-Perot Resonator Antenna Fed by CPW with High Gain and Broadband

    Directory of Open Access Journals (Sweden)

    Xue-Xia Yang

    2016-01-01

    Full Text Available A novel millimeter wave coplanar waveguide (CPW fed Fabry-Perot (F-P antenna with high gain, broad bandwidth, and low profile is reported. The partially reflective surface (PRS and the ground form the F-P resonator cavity, which is filled with the same dielectric substrate. A dual rhombic slot loop on the ground acts as the primary feeding antenna, which is fed by the CPW and has broad bandwidth. In order to improve the antenna gain, metal vias are inserted surrounding the F-P cavity. A CPW-to-microstrip transition is designed to measure the performances of the antenna and extend the applications. The measured impedance bandwidth of S11 less than −10 dB is from 34 to 37.7 GHz (10.5%, and the gain is 15.4 dBi at the center frequency of 35 GHz with a 3 dB gain bandwidth of 7.1%. This performance of the antenna shows a tradeoff among gain, bandwidth, and profile.

  16. Design of anisotropic focusing metasurface and its application for high-gain lens antenna

    Science.gov (United States)

    Guo, Wenlong; Wang, Guangming; Li, Haipeng; Li, Tangjing; Ge, Qichao; Zhuang, Yaqiang

    2017-03-01

    In this paper, we propose an anisotropic focusing metasurface with function of focusing orthogonally polarized waves in refraction and reflection modes respectively. By employing four layered metallic patches spaced by triple layered dielectric spacers, an anisotropic phase element is designed with capability of transmitting x-polarized waves but reflecting y-polarized beams efficiently. Composed of 21 × 21 cells and with size of 105 × 105 mm2, a focusing metasurface operating at 15 GHz is designed with the same focal length of 30 mm for x- and y-polarized waves. By setting a patch antenna at the focal point, the metasurface sample is employed to enhance gain of the radiation source. For verification, the metasurface sample is fabricated and measured. The antenna performance, in terms of realized boresight gain and operating bandwidth under x- and y-polarized waves illumination, is presented. Results show that the 1 dB gain bandwidths are respectively from 14.7 to 15.3 GHz and 14.7 to 15.2 GHz, and the gain are enhanced by 14.1 dB, 15.1 dB in refraction and reflection modes when the metasurface is impinged by x- and y-polarized spherical waves. The proposed anisotropic metasurface may afford an alternative for designing anisotropic planar lens or high-gain antenna.

  17. High gain GaAs photoconductive semiconductor switches for ground penetrating radar

    Energy Technology Data Exchange (ETDEWEB)

    Loubriel, G.M.; Aurand, J.F.; Buttram, M.T.; Zutavern, F.J.; Helgeson, W.D.; O`Malley, M.W. [Sandia National Labs., Albuquerque, NM (United States); Brown, D.J. [Ktech Corp., Albuquerque, NM (United States)

    1996-07-01

    The ability of high gain GaAs Photoconductive Semiconductor switches (PCSS) to deliver high peak power, fast risetime pulses when triggered with small laser diode arrays makes them suitable for their use in radars that rely on fast impulses. This type of direct time domain radar is uniquely suited for observation of large structures under ground because it can operate at low frequencies and at high average power. This paper will summarize the state-of-the-art in high gain GaAs switches and discuss their use in a radar transmitter. We will also present a summary of an analysis of the effectiveness of different pulser geometries that result in transmitted pulses with varying frequency content. To this end we developed a simple model that includes transmit and receive antenna response, attenuation and dispersion of the electromagnetic impulses by the soil, and target cross sections.

  18. Femtosecond Ti:sapphire cryogenic amplifier with high gain and MHz repetition rate.

    Science.gov (United States)

    Dantan, Aurélien; Laurat, Julien; Ourjoumtsev, Alexei; Tualle-Brouri, Rosa; Grangier, Philippe

    2007-07-09

    We demonstrate high gain amplification of 160-femtosecond pulses in a compact double-pass cryogenic Ti:sapphire amplifier. The setup involves a negative GVD mirrors recompression stage, and operates with a repetition rate between 0.2 and 4 MHz with a continuous pump laser. Amplification factors as high as 17 and 320 nJ Fourier-limited pulses are obtained at a 800 kHz repetition rate.

  19. A Coherent Compton Backscattering High Gain FEL using an X-Band Microwave Undulator

    Energy Technology Data Exchange (ETDEWEB)

    Tantawi, S.; Dolgashev, V.; Nantista, C.; /SLAC; Pellegrini, C.; Rosenzweig, J.; Travish, G.; /UCLA

    2005-12-14

    High power microwave sources at X-Band, delivering 400 to 500 of megawatts for about 400 ns, have been recently developed. These sources can power a microwave undulator with short period and large gap, and can be used in short wavelength FELs reaching the nm region at a beam energy of about 1 GeV. We present here an experiment designed to demonstrate that microwave undulators have the field quality needed for high gain FELs.

  20. Novel High-Gain Circularly Polarized Lens Antenna Using Single-Layer Transmissive Metasurface

    Science.gov (United States)

    Zhuang, Yaqiang; Wang, Guangming; Li, Haipeng; Guo, Wenlong

    2017-03-01

    A high-gain lens antenna employing single-layer focusing metasurface (MS) is proposed in this article. The single-layer element achieves a 360° transmission phase range with a transmission magnitude better than 0.9. And the focusing MS consists of 169 elements was designed by utilizing the technique of varying rotation angle to compensate the phase delay. Thus, a lens antenna is constructed by placing a circularly polarized (CP) patch antenna at the focal point of the MS. The fabricated lens antenna demonstrates a good performance of 4.6 % 3-dB axial ratio bandwidth and 6 % 1-dB gain bandwidth, respectively. Moreover, the maximum gain is 18.3 dBic at 15 GHz, which is enhanced by 11.4 dBic compared with the patch antenna. Due to the single-layer structure, this design has a low profile and easy fabrication process compared with the conventional designs, making it an attractive alternative to compact high-gain antenna.

  1. (-)-Epigallocatechin-3-gallate inhibits pancreatic lipase and reduces body weight gain in high fat-fed obese mice.

    Science.gov (United States)

    Grove, Kimberly A; Sae-tan, Sudathip; Kennett, Mary J; Lambert, Joshua D

    2012-11-01

    Tea (Camellia sinensis, Theaceae) has been shown to have obesity preventive effects in laboratory studies. We hypothesized that dietary epigallocatechin-3-gallate (EGCG) could reverse metabolic syndrome in high fat-fed obese C57bl/6J mice, and that these effects were related to inhibition of pancreatic lipase (PL). Following treatment with 0.32% EGCG for 6 weeks, a 44% decrease in body weight (BW) gain in high fat-fed, obese mice (P EGCG treatment increased fecal lipid content by 29.4% (P fat-fed control, whereas in vitro, EGCG dose-dependently inhibited PL (IC(50) = 7.5 µmol/l) in a noncompetitive manner with respect to substrate concentration. (-)-Epicatechin-3-gallate exhibited similar inhibitory activity, whereas the nonester-containing (-)-epigallocatechin did not. In conclusion, EGCG supplementation reduced final BW and BW gain in obese mice, and some of these effects may be due to inhibition of PL by EGCG.

  2. Whey protein reduces early life weight gain in mice fed a high-fat diet

    DEFF Research Database (Denmark)

    Tranberg, Britt; Hellgren, Lars; Lykkesfeldt, Jens;

    2013-01-01

    An increasing number of studies indicate that dairy products, including whey protein, alleviate several disorders of the metabolic syndrome. Here, we investigated the effects of whey protein isolate (whey) in mice fed a high-fat diet hypothesising that the metabolic effects of whey would...... be associated with changes in the gut microbiota composition. Five-week-old male C57BL/6 mice were fed a high-fat diet ad libitum for 14 weeks with the protein source being either whey or casein. Faeces were collected at week 0, 7, and 13 and the fecal microbiota was analysed by denaturing gradient gel...... reduced weight gain in young C57BL/6 mice fed a high-fat diet compared to casein. Although the effect on weight gain ceased, whey alleviated glucose intolerance, improved insulin sensitivity and reduced plasma cholesterol. These findings could not be explained by changes in food intake or gut microbiota...

  3. Pregnant women's perceptions of weight gain, physical activity, and nutrition using Theory of Planned Behavior constructs.

    Science.gov (United States)

    Whitaker, Kara M; Wilcox, Sara; Liu, Jihong; Blair, Steven N; Pate, Russell R

    2016-02-01

    A better understanding of women's perceptions of weight gain and related behaviors during pregnancy is necessary to inform behavioral interventions. We used the Theory of Planned Behavior (TPB) to examine pregnant women's perceptions and intentions toward weight gain, physical activity (PA), and nutrition using a mixed methods study design. Women between 20 and 30 weeks gestation (n = 189) were recruited to complete an Internet-based survey. Salient beliefs toward weight gain, PA, and nutrition were captured through open-ended responses and content analyzed into themes. TPB constructs (attitude, subjective norm, perceived behavioral control, intentions) were examined using Pearson correlations and hierarchical linear regression models. Salient beliefs were consistent with the existing literature in non-pregnant populations, with the addition of many pregnancy-specific beliefs. TPB constructs accounted for 23-39 % of the variance in weight gain, PA, and nutrition intentions, and made varying contributions across outcomes. The TPB is a useful framework for examining women's weight-related intentions during pregnancy. Study implications for intervention development are discussed.

  4. Excess Folic Acid Increases Lipid Storage, Weight Gain, and Adipose Tissue Inflammation in High Fat Diet-Fed Rats

    Directory of Open Access Journals (Sweden)

    Karen B. Kelly

    2016-09-01

    Full Text Available Folic acid intake has increased to high levels in many countries, raising concerns about possible adverse effects, including disturbances to energy and lipid metabolism. Our aim was to investigate the effects of excess folic acid (EFA intake compared to adequate folic acid (AFA intake on metabolic health in a rodent model. We conducted these investigations in the setting of either a 15% energy low fat (LF diet or 60% energy high fat (HF diet. There was no difference in weight gain, fat mass, or glucose tolerance in EFA-fed rats compared to AFA-fed rats when they were fed a LF diet. However, rats fed EFA in combination with a HF diet had significantly greater weight gain and fat mass compared to rats fed AFA (p < 0.05. Gene expression analysis showed increased mRNA levels of peroxisome proliferator-activated receptor γ (PPARγ and some of its target genes in adipose tissue of high fat-excess folic acid (HF-EFA fed rats. Inflammation was increased in HF-EFA fed rats, associated with impaired glucose tolerance compared to high fat-adequate folic acid (HF-AFA fed rats (p < 0.05. In addition, folic acid induced PPARγ expression and triglyceride accumulation in 3T3-L1 cells. Our results suggest that excess folic acid may exacerbate weight gain, fat accumulation, and inflammation caused by consumption of a HF diet.

  5. A differential low-voltage high gain current-mode integrated RF receiver front-end

    Science.gov (United States)

    Chunhua, Wang; Minglin, Ma; Jingru, Sun; Sichun, Du; Xiaorong, Guo; Haizhen, He

    2011-02-01

    A differential low-voltage high gain current-mode integrated RF front end for an 802.11b WLAN is proposed. It contains a differential transconductance low noise amplifier (Gm-LNA) and a differential current-mode down converted mixer. The single terminal of the Gm-LNA contains just one MOS transistor, two capacitors and two inductors. The gate-source shunt capacitors, Cx1 and Cx2, can not only reduce the effects of gate-source Cgs on resonance frequency and input-matching impedance, but they also enable the gate inductance Lg1,2 to be selected at a very small value. The current-mode mixer is composed of four switched current mirrors. Adjusting the ratio of the drain channel sizes of the switched current mirrors can increase the gain of the mixer and accordingly increase the gain of RF receiver front-end. The RF front-end operates under 1 V supply voltage. The receiver RFIC was fabricated using a chartered 0.18 μm CMOS process. The integrated RF receiver front-end has a measured power conversion gain of 17.48 dB and an input referred third-order intercept point (IIP3) of -7.02 dBm. The total noise figure is 4.5 dB and the power is only 14 mW by post-simulations.

  6. High-energy electron induced gain degradation in bipolar junction transistors

    Energy Technology Data Exchange (ETDEWEB)

    Kulkarni, S.R. [Department of PG Studies in Physics, SBMJC, Jayanagar, Bangalore 560 011 (India)]. E-mail: srinivask24@hotmail.com; Ravindra, M. [Components Division, ICG, ISRO Satellite Centre, Airport Road, Bangalore 560 017 (India); Joshi, G.R. [Components Division, ICG, ISRO Satellite Centre, Airport Road, Bangalore 560 017 (India); Damle, R. [Department of Physics, Bangalore University, Bangalore 560 056 (India)]. E-mail: damleraju@yahoo.com

    2006-09-15

    This paper describes the effect of 8 MeV electron beam on the forward current gain of space borne commercial indigenous bipolar junction transistors 2N2219A (npn), 2N3019 (npn) and 2N2905A (pnp). The devices are exposed to 8 MeV electron in the biased condition. The collector characteristics and Gummel plots are obtained as a function of accumulated dose. An excess base current model as well as Messenger-Spratt equation have been used to account for the observed gain degradation. The results indicate that 8 MeV electrons of high dose rate induce gain degradation by increasing the base current as well as decrease in collector current. The current gain degradation appears to be predominantly due to displacement damage in the bulk of the transistor. Off-line measurements of the h {sub FE} of the irradiated transistors indicate that the displacement induced defect and recombination centers do not anneal even at 150 {sup o}C.

  7. High-gain direct-drive inertial confinement fusion for the Laser Megajoule: recent progress

    Energy Technology Data Exchange (ETDEWEB)

    Canaud, B [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Garaude, F [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Ballereau, P [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Bourgade, J L [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Clique, C [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Dureau, D [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Houry, M [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Jaouen, S [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Jourdren, H [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Lecler, N [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Masse, L [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Masson, A [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Quach, R [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Piron, R [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Riz, D [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Vliet, J van der [CEA/DAM Ile-de-France, BP12, F-91680 Bruyeres-le-Chatel, Cedex (France); Temporal, M [Calle Grau, 685, Sucre (Bolivia); Delettrez, J A [Laboratory of Laser Energetics, University of Rochester, 250 East River Road, Rochester, NY 14623 (United States); McKenty, P W [Laboratory of Laser Energetics, University of Rochester, 250 East River Road, Rochester, NY 14623 (United States)

    2007-12-15

    Recent progress in high-gain direct-drive inertial confinement fusion with the laser Megajoule is reviewed. A new baseline direct-drive target design is presented which implodes with a two-cones irradiation pattern of indirect-drive beam configuration and zooming. Perturbation amplitudes and correlated growth rates of hydrodynamic instabilities in the compressed core of a directly driven inertial confinement fusion capsule are analyzed in planar and spherical geometries, with and without heat conduction, in the unsteady state regime of the deceleration. Shock propagation in heterogeneous media is addressed in the context of first shock. The neutron and photon emissions of high-gain direct-drive target are characterized. Numerical interpretations of directly driven homothetic cryogenic D{sub 2} target implosion experiments on the Omega facility are presented.

  8. Nonlinear harmonics in the high-gain harmonic generation (HGHG) experiment

    CERN Document Server

    Biedron, S G; Milton, S V; Yu, L H; Wang, X J

    2001-01-01

    We have previously performed rigorous analyses of the nonlinear harmonics in self-amplified spontaneous emission (SASE) free-electron lasers (FELs) using a 3D simulation code. To date, we have presented only preliminary results of these higher harmonics resulting in the high-gain harmonic generation (HGHG) process. A single-pass, high-gain FEL experiment based on the HGHG theory is underway at the Accelerator Test Facility (ATF) at Brookhaven National Laboratory (BNL) in collaboration with the Advanced Photon Source (APS) at Argonne National Laboratory (ANL). Using the above experiment's design parameters, the specific case of the harmonic output from the HGHG experiment will be examined using a 3D simulation code. The sensitivity of nonlinear harmonic output for this HGHG experiment as functions of emittance, energy spread, and peak current in both cases, and for the dispersive section strength and input seed power in the HGHG case, will be presented.

  9. High power double-scale pulses from a gain-guided double-clad fiber laser

    Science.gov (United States)

    Zhang, Haitao; Gao, Gan; Li, Qinghua; Gong, Mali

    2017-03-01

    Generation of high power double-scale pulses from a gain-guided double-clad fiber laser is experimentally demonstrated. By employing the Yb-doped 10/130 double-clad fiber as the gain medium, the laser realizes an output power of 5.1 W and pulse energy of 0.175 µJ at repetition rate of 29.14 MHz. To the best of our knowledge, this average output power is the highest among the reported double-scale pulse oscillators. The autocorrelation trace of pulses contains the short (98 fs) and long (29.5 ps) components, and the spectral bandwidth of the pulse is 27.3 nm. Such double-scale pulses are well suited for seeding the high power MOPA (master oscillator power amplifier) systems, nonlinear frequency conversion and optical coherence tomography.

  10. First lasing of a high-gain harmonic generation free- electron laser experiment

    CERN Document Server

    Yu, L H; Ben-Zvi, I; Di Mauro, Louis F; Doyuran, A; Graves, W; Johnson, E; Krinsky, S; Malone, R; Pogorelsky, I V; Skaritka, J; Rakowsky, G; Solomon, L; Wang, X J; Woodle, M; Yakimenko, V; Biedron, S G; Galayda, J N; Gluskin, E; Jagger, J; Sajaev, Vadim; Vasserman, I

    2000-01-01

    We report on the first lasing of a high-gain harmonic generation (HGHG) free-electron laser (FEL). The experiment was conducted at the Accelerator Test Facility (ATF) at Brookhaven National Laboratory (BNL). This is a BNL experiment in collaboration with the Advanced Photon Source (APS) at Argonne National Laboratory. A preliminary measurement gives a high-gain harmonic generation (HGHG) pulse energy that is 2x10 sup 7 times larger than the spontaneous radiation. In a purely self-amplified spontaneous emission (SASE) mode of operation, the signal was measured as 10 times larger than the spontaneous radiation in the same distance (approx 2 m) through the same wiggler. This means the HGHG signal is 2x10 sup 6 times larger than the SASE signal. To obtain the same saturated output power by the SASE process, the radiator would have to be 3 times longer (6 m).

  11. Achievement of public health recommendations for physical activity and prevention of gains in adiposity in adults

    DEFF Research Database (Denmark)

    Grøntved, A.

    2013-01-01

    Physical activity (PA) is considered a cornerstone in weight control and public health guidelines recommend regular participation to prevent gains in adiposity. It may therefore come as a surprise that the cumulative evidence from observational studies to support this is not strong. A weakness...... of many published observational studies on this topic has been a reliance on a single baseline assessment of PA. Using only the baseline information on PA in a prospective study cause misclassification because of participants often change activity level during follow-up. In turn this causes regression...

  12. Gain engineering for all-optical microwave and high speed pulse generation in mode-locked fiber lasers

    Science.gov (United States)

    Li, Fangxin; Helmy, Amr S.

    2014-03-01

    Pulsed sources based on approaches that employ only photonic components and no RF components will be discussed in this talk. Several technologies have been explored to generate actively mode-locked sources using electronically driven fiber ring cavities. However, for these sources the pulse repetition rate is usually limited by the bandwidth of the intracavity modulator. Filtering of highly-stable low repetition rate optical combs utilizing cavities such as Fabry-Perot etalons can be used to overcome this limitation. This scheme is not flexible as it requires highly precise control of ultrahigh finesse etalons which limits the repetition rate to the free spectral range of the filter. Pulsed sources based on semiconductor devices offer many advantages, including large gain bandwidth, rapid tunability, long-term stability. In this work we introduce a novel, simple method to generate optical clock with wavelength tunability using two continuous wave (CW) lasers. The lasers are injected into a conventional SOAs-based fiber ring laser. The beating signal generated by these two lasers causes the modulation of the SOA gain saturation inside the cavity. Thus, the SOA provides gain and functions as the modulator as well as the gain medium. When the lasing mode inside the cavity is amplified, it also results in gain-induced four wave mixing. The proposed technique is particularly versatile, overcoming the bandwidth limitation of other techniques, which require RF sources. Moreover, this technique provides the possibility for hybrid integration as it is comprised of semiconductor chips that can be heterogeneously integrated on a Si platform.

  13. Effects of the pacifier activated lullaby on weight gain of premature infants.

    Science.gov (United States)

    Cevasco, Andrea M; Grant, Roy E

    2005-01-01

    Within the past 5 years there has been an increase of premature infants surviving in the neonatal intensive care unit as well as an increasing cost for each day the infant is kept there. It is important for the premature infant to acquire the feeding skills necessary for weight gain, which lead to discharge from the hospital, and recent advancements have indicated the effectiveness in using contingent music to teach sucking skills to premature infants. The purpose of the first analysis in this study was to determine the effects of Pacifier Activated Lullaby (PAL) trials on weight gain of premature infants. During a 2-year time period, 62 infants from a sample of 188 met criteria for analysis. A one-way analysis of variance showed no significance in daily weight gain for the number of PAL trials completed. The mean weight gains for infants with 1 PAL trial = 13.85 grams, 2 trials = 26.67, 3 trials = 29.64, and 4 or more = 22.89. The Pearson product-moment correlation between the mean percent of music earned via nonnutritive sucking (NNS) and mean weight gain of all trials approached significance (p = .077, r = 0.18). In a second analysis, weight gained prior to use of PAL, during use of PAL, and post use of PAL was analyzed. Results indicated no significant difference between weight gain 1 day prior to use of PAL, the day of PAL trial, and 1 day post use of PAL. Mean weight gain for those infants who participated in 1 PAL trial was 8.49 grams for 1 day prior to use of PAL, 18.73 the day of PAL trial, and 24.81 for 1 day post use of PAL. Mean weight gain for 3 days prior to using the PAL was 10.78, 11.30 on the day of PAL trial, and 24.78 grams for 3 days post PAL use. The analyses show definite trends of greater weight gain with PAL use; however, individual variability within groups was greater than group differences leading to no significance in statistical analysis. In the third analysis the effect of proximity between premature infants' feeding schedule and PAL

  14. Optical gain from vertical Ge-on-Si resonant-cavity light emitting diodes with dual active regions

    Science.gov (United States)

    Lin, Guangyang; Wang, Jiaqi; Huang, Zhiwei; Mao, Yichen; Li, Cheng; Huang, Wei; Chen, Songyan; Lai, Hongkai; Huang, Shihao

    2017-09-01

    Vertical resonant-cavity light emitting diodes with dual active regions consisting of highly n-doped Ge/GeSi multiple quantum wells (MQWs) and a Ge epilayer are proposed to improve the light emitting efficiency. The MQWs are designed to optically pump the underlying Ge epilayer under electric injection. Abundant excess carriers can be optically pumped into the Γ valley of the Ge epilayer apart from electric pumping. With the combination of a vertical cavity, the efficiency of the optical-pumping process was effectively improved due to the elongation of the optical length in the cavity. With the unique feature, optical gain from the Ge epilayer is observed between 1625 and 1700 nm at injection current densities of >1.528 kA/cm2. The demonstration of optical gain from the Ge epilayer indicates that this strategy can be generally useful for Si-based light sources with indirect band materials.

  15. A Vehicle Haptic Steering by Wire System Based on High Gain GPI Observers

    Directory of Open Access Journals (Sweden)

    A. Rodriguez-Angeles

    2014-01-01

    Full Text Available A vehicle steering by wire (SBW haptic system based on high gain generalized proportional integral (GPI observers is introduced. The observers are considered for the estimation of dynamic perturbations that are present at the tire and steering wheel. To ensure efficient tracking between the commanded steering wheel angle and the tire orientation angle, the estimated perturbations are on line canceled. As to provide a haptic interface with the driver, the estimated dynamic effects at the steering rack are fed back to the steering wheel, yielding a master-slave haptic system with bilateral communication. For implementation purposes few sensors and minimum knowledge of the dynamic model are required, which is a major advantage compared to other approaches. Only position tracking errors are fed back, while all other signals are estimated by the high gain GPI observers. The scheme is robust to uncertainty on the input gain and cancels dynamic perturbation effects such as friction and aligning forces on the tire. Experimental results are presented on a prototype platform.

  16. Design of high-gain, wideband antenna using microwave hyperbolic metasurface

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Yan, E-mail: yan.z@chula.ac.th [International School of Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok 10330 (Thailand)

    2016-05-15

    In this work, we apply hyperbolic metasurfaces (HMSs) to design high-gain and wideband antennas. It is shown that HMSs formed by a single layer of split-ring resonators (SRRs) can be excited to generate highly directive beams. In particular, we suggest two types of the SRR-HMS: a capacitively loaded SRR (CLSRR)-HMS and a substrate-backed double SRR (DSRR)-HMS. Both configurations ensure that the periodicity of the structures is sufficiently small for satisfying the effective medium theory. For the antenna design, we propose a two-layer-stacked configuration for the 2.4 GHz frequency band based on the DSRR-HMS excited by a folded monopole. Measurement results confirm numerical simulations and demonstrate that an antenna gain of more than 5 dBi can be obtained for the frequency range of 2.1 - 2.6 GHz, with a maximum gain of 7.8 dBi at 2.4 GHz.

  17. Olanzapine-high potency antipsychotic drug inducing significant weight gain: A case report

    Directory of Open Access Journals (Sweden)

    Marić Nađa P.

    2008-01-01

    Full Text Available INTRODUCTION Olanzapine is a second generation antipsychotic (SGA with a high level of therapeutic effectiveness in schizophrenia and other psychotic disorders. Along with the positive therapeutic effects, an increase of the body weight frequently occurs. According to the literature, the average weight gain is about 6-7 kg during several months of treatment. This could be valued as a moderate weight increase. CASE OUTLINE This article presents a case of a young female with schizophrenia, without clinical improvement with several antipsychotics (clozapine, risperidone, haloperidol and with the occurrence of significant neurological side effects. The treatment started with olanzapine (baseline was associated with good initial response (PANSS reduction 20% in the first two weeks and the improvement was maintained further on (PANSS reduction 50% after 16 weeks. Significant increase (20 kg, 40% in weight appeared during the following 16 weeks (BMI at baseline 17.9 kg/m2; BMI 16 weeks later 25.1 kg/m2. CONCLUSION High effectiveness of olanzapine in schizophrenia symptoms reduction was accompanied by a significant weight gain. However, this drug leads to impaired glucoregulation, dyslipidaemia etc. It also increases the risk of diabetes and cardio-vascular diseases, i.e. the main causes of mortality in schizophrenia after a suicide. Therefore, clinicians are suggested to focus on possible predictors of weight gain during olanzapine therapy, and act accordingly in order to prevent serious health consequences.

  18. A bootstrapped, low-noise, and high-gain photodetector for shot noise measurement.

    Science.gov (United States)

    Zhou, Haijun; Yang, Wenhai; Li, Zhixiu; Li, Xuefeng; Zheng, Yaohui

    2014-01-01

    We presented a low-noise, high-gain photodetector based on the bootstrap structure and the L-C (inductance and capacitance) combination. Electronic characteristics of the photodetector, including electronic noise, gain and frequency response, and dynamic range, were verified through a single-frequency Nd:YVO4 laser at 1064 nm with coherent output. The measured shot noise of 50 μW laser was 13 dB above the electronic noise at the analysis frequency of 2 MHz, and 10 dB at 3 MHz. And a maximum clearance of 28 dB at 2 MHz was achieved when 1.52 mW laser was illuminated. In addition, the photodetector showed excellent linearities for both DC and AC amplifications in the laser power range between 12.5 μW and 1.52 mW.

  19. High-gain multipassed Yb:YAG amplifier for ultrashort pulse laser

    Science.gov (United States)

    Vetrovec, John; Copeland, Drew A.; Litt, Amardeep S.; Du, Detao

    2016-05-01

    We report on a Yb:YAG laser amplifier for ultrashort pulse applications at kW-class average power. The laser uses two large-aperture, disk-type gain elements fabricated from composite ceramic YAG material, and a multi-pass extraction architecture to obtain high gain in a chirped-pulse amplification system. The disks are edge-pumped, thus allowing for reduced doping of the host material with laser ions, which translates to lower lasing threshold and lower heat dissipation in the Yb:YAG material. The latter makes it possible to amplify a near diffraction-limited seed without significant thermo-optical distortions. This work presents results of testing the laser amplifier with relay optics and passive polarization switching configured for energy extraction with up to 40 passes through the disks. Applications for the ultrashort pulse laser amplifier include producing a laser-induced plasma channel, laser material ablation, and laser acceleration of atomic particles.

  20. Inkjet printing of novel wideband and high gain antennas on low-cost paper substrate

    KAUST Repository

    Cook, Benjamin Stassen

    2012-09-01

    A complete characterization of the inkjet printing process using metallic nanoparticle inks on a paper substrate for microwave frequencies up to 12.5 GHz as well as its application to low-cost, high gain and wideband antenna design are demonstrated in this work. Laser and heat sintering of metallic nanoparticles are compared on paper substrate for the first time which demonstrate immense cost and time benefits of laser sintering. The antennas fabricated using the characterized process include a Vivaldi for the UWB band which exhibits a significantly higher gain of up to 8 dBi as compared to the currently published inkjet printed antennas, and a novel slow-wave log periodic dipole array which employs a new miniaturization technique to show 20% width reduction. © 1963-2012 IEEE.

  1. High gain broadband amplification of ultraviolet pulses in optical parametric chirped pulse amplifier.

    Science.gov (United States)

    Wnuk, Paweł; Stepanenko, Yuriy; Radzewicz, Czesław

    2010-04-12

    We report on a high gain amplification of broadband ultraviolet femtosecond pulses in an optical parametric chirped pulse amplifier. Broadband ultraviolet seed pulses were obtained by an achromatic frequency doubling of the output from a femtosecond Ti:Sapphire oscillator. Stretched seed pulses were amplified in a multipass parametric amplifier with a single BBO crystal pumped by a ns frequency quadrupled Nd:YAG laser. A noncollinear configuration was used for a broadband amplification. The total (after compression) amplification of 2.510(5) was achieved, with compressed pulse energy of 30 microJ and pulse duration of 24 fs. We found that the measured gain was limited by thermal effects induced by the absorption of the pump laser by color centers created in the BBO crystal.

  2. Interpolating gain-scheduled H∞ loop shaping design for high speed ball screw feed drives.

    Science.gov (United States)

    Dong, Liang; Tang, WenCheng; Bao, DaFei

    2015-03-01

    This paper presents a method to design servo controllers for flexible ball screw drives with time-varying dynamics, which are mainly due to the time-varying table position and the workpiece mass. A gain-scheduled H∞ loop shaping controller is designed to achieve high tracking performance against the dynamic variations. H∞ loop shaping design procedure incorporates open loop shaping by a set of compensators to obtain performance/robust stability tradeoffs. The interpolating gain-scheduled controller is obtained by interpolating the state space model of the linear time-invariant (LTI) controllers estimated for fixed values of the scheduling parameters and a linear least squares problem can be solved. The proposed controller has been compared with P/PI with velocity and acceleration feedforward and adaptive backstepping sliding mode control experimentally. The experimental results indicate that the tracking performance has been improved and the robustness for time-varying dynamics has been achieved with the proposed scheme.

  3. A bootstrapped, low-noise, and high-gain photodetector for shot noise measurement

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Haijun; Yang, Wenhai; Li, Zhixiu; Li, Xuefeng; Zheng, Yaohui, E-mail: yhzheng@sxu.edu.cn [State Key Laboratory of Quantum Optics and Quantum Optics Devices, Institute of Opto-Electronics, Shanxi University, Taiyuan 030006 (China)

    2014-01-15

    We presented a low-noise, high-gain photodetector based on the bootstrap structure and the L-C (inductance and capacitance) combination. Electronic characteristics of the photodetector, including electronic noise, gain and frequency response, and dynamic range, were verified through a single-frequency Nd:YVO{sub 4} laser at 1064 nm with coherent output. The measured shot noise of 50 μW laser was 13 dB above the electronic noise at the analysis frequency of 2 MHz, and 10 dB at 3 MHz. And a maximum clearance of 28 dB at 2 MHz was achieved when 1.52 mW laser was illuminated. In addition, the photodetector showed excellent linearities for both DC and AC amplifications in the laser power range between 12.5 μW and 1.52 mW.

  4. Modeling and Analysis of Transformerless High Gain Buck-boost DC-DC Converters

    Directory of Open Access Journals (Sweden)

    Vu Tran

    2014-12-01

    Full Text Available This paper proposes a transfomerless switched capacitor buck boost converter model, which provides higher voltage gain and higher efficiency when compared to the conventional buck boost converter. The averaged model based on state-space description is analyzed in the paper. The simulation results are presented to confirm the capability of the converter to generate high voltage ratios. The comparison between the proposed model and the traditional model is also provided to reveal the improvement. The proposed converter is suitable for for a wide application which requires high step-up DC-DC converters such as DC micro-grids and solar electrical energy.

  5. A new Design for an High Gain Vacuum Photomultiplier: The Silicon PMT Used as Amplification Stage

    Energy Technology Data Exchange (ETDEWEB)

    Barbarino, Giancarlo [Universita di Napoli ' Federico II' , Dipartimento di Scienze fisiche, via Cintia 80126 Napoli (Italy); Asmundis, Riccardo de; De Rosa, Gianfranca [Istituto Nazionale di fisica Nucleare, sezione di Napoli, Complesso di Monte S. Angelo Ed. 6, via Cintia 80126 Napoli (Italy); Fiorillo, Giuliana; Russo, Stefano [Universita di Napoli ' Federico II' , Dipartimento di Scienze fisiche, via Cintia 80126 Napoli (Italy)

    2009-12-15

    Photons detection will continue to be a channel of great interest in the High Energy Physics and Astroparticle Physics fields for medium and big scale experiments in the next future. Thus, new solutions for photon detectors, that overcome the current limits of classical photomultipliers, are welcomed. We propose an innovative design for a hybrid, modern, high gain Vacuum Silicon Photomultiplier Tube (VSiPMT) which is boosted by the recent Geiger-mode avalanche silicon photodiode (G-APD) for which a massive production is today available.

  6. Amplification of background EMG activity affects the interpretation of H-reflex gain.

    Science.gov (United States)

    Tahayori, Behdad; Kitano, Koichi; Hong, Siang L; Koceja, David M

    2010-12-01

    In many H-reflex studies, the modulation of the H-reflex is usually compared relative to the normal EMG activity within the muscle. Such comparisons enable the investigators to infer whether the change in the amplitude of the H-reflex was independent of normally occurring muscle activity. This interpretation of the H-reflex is regarded as H-reflex gain, a popular dependent variable in human H-reflex studies. However, in many studies to date, the muscle activity level has been determined from the same EMG signal from which the H-reflex is recorded. This leads to an important methodological consideration: measuring the ongoing normal EMG activity from the same signal might result in an inaccurate measurement, since this EMG signal will need to be minimally amplified to capture the synchronous volley of the H-reflex amplitude. In this study we examined this possibility and found that comparing the EMG activity level from the seated position to standing position yields different results (on average 8.03% in the measurement of the increase of muscle activity). This difference was both dependent on the task and also on the EMG instrumentation used. To solve this problem we suggest the bifurcation of the EMG signal from the recording electrodes with differential amplification of the signal. With this method, both the naturally occurring muscle activity and the H-reflex signal are collected from the same area of the muscle and a more accurate measurement of the H-reflex gain will be yielded.

  7. Lean rats gained more body weight from a high-fructooligosaccharide diet.

    Science.gov (United States)

    Li, Shaoting; Yingyi, Gu; Chen, Long; Lijuan, Gao; Ou, Shiyi; Peng, Xichun

    2015-07-01

    Fructooligosaccharides (FOS) are believed to be beneficial to the host growth and its gut health. This article is intended to investigate the different influences of a high-fructooligosaccharide (FOS) diet on the growth and gut microbiota of lean and obese rats. Diet-induced lean and obese rats were fed a high-FOS diet for 8 weeks. Rats' body weight (BW) and feed intake were recorded weekly, and their gut microbiota was analyzed by 16S rDNA sequencing. The results showed that the lean rats gained more BW than the obese ones from the high-FOS diet. In the meanwhile, the gut microbiota in both lean and obese rats was altered by this diet. The abundance of Bacteroidetes was increased significantly (P diet. In conclusion, this study first reported that the lean rats gained more body weight from a high-FOS diet than the obese ones, and the increase of Bacteroidetes might help rats harvest more energy from the high-FOS diet.

  8. Analysis of the Optimum Gain of a High-Pass L-Matching Network for Rectennas

    Directory of Open Access Journals (Sweden)

    Manel Gasulla

    2017-07-01

    Full Text Available Rectennas, which mainly consist of an antenna, matching network, and rectifier, are used to harvest radiofrequency energy in order to power tiny sensor nodes, e.g., the nodes of the Internet of Things. This paper demonstrates for the first time, the existence of an optimum voltage gain for high-pass L-matching networks used in rectennas by deriving an analytical expression. The optimum gain is that which leads to maximum power efficiency of the rectenna. Here, apart from the L-matching network, a Schottky single-diode rectifier was used for the rectenna, which was optimized at 868 MHz for a power range from −30 dBm to −10 dBm. As the theoretical expression depends on parameters not very well-known a priori, an accurate search of the optimum gain for each power level was performed via simulations. Experimental results show remarkable power efficiencies ranging from 16% at −30 dBm to 55% at −10 dBm, which are for almost all the tested power levels the highest published in the literature for similar designs.

  9. Analysis of the Optimum Gain of a High-Pass L-Matching Network for Rectennas.

    Science.gov (United States)

    Gasulla, Manel; Jordana, Josep; Robert, Francesc-Josep; Berenguer, Jordi

    2017-07-25

    Rectennas, which mainly consist of an antenna, matching network, and rectifier, are used to harvest radiofrequency energy in order to power tiny sensor nodes, e.g., the nodes of the Internet of Things. This paper demonstrates for the first time, the existence of an optimum voltage gain for high-pass L-matching networks used in rectennas by deriving an analytical expression. The optimum gain is that which leads to maximum power efficiency of the rectenna. Here, apart from the L-matching network, a Schottky single-diode rectifier was used for the rectenna, which was optimized at 868 MHz for a power range from -30 dBm to -10 dBm. As the theoretical expression depends on parameters not very well-known a priori, an accurate search of the optimum gain for each power level was performed via simulations. Experimental results show remarkable power efficiencies ranging from 16% at -30 dBm to 55% at -10 dBm, which are for almost all the tested power levels the highest published in the literature for similar designs.

  10. Design of High Gain and Broadband Antennas at 60 GHz for Underground Communications Systems

    Directory of Open Access Journals (Sweden)

    Yacouba Coulibaly

    2012-01-01

    Full Text Available A new broadband and high gain dielectric resonator antenna for millimeter wave is presented. The investigated antenna configuration consists of a periodic square ring frequency selective surfaces on a superstrate, an aperture-coupled scheme feed, an intermediate substrate, and a cylindrical dielectric resonator. This antenna is designed to cover the ISM frequency band at 60 GHz (57 GHz–64 GHz. It was numerically designed using CST microwave Studio simulation software package. Another prototype with a plain dielectric superstrate is also studied for comparison purposes. A bandwidth of 13.56% at the centered frequency of 61.34 GHz and a gain of 11 dB over the entire ISM band have been achieved. A maximum gain of 14.26 dB is obtained at 60 GHz. This is an enhancement of 9 dB compared to a single DRA. HFSS is used to validate our antenna designs. Good agreement between the results of the two softwares is obtained. With these performances, these antennas promise to be useful in the design of future wireless underground communication systems operating in the unlicensed 60 GHz frequency band.

  11. The general solution of the eigenvalue problem for a high-gain FEL

    CERN Document Server

    Saldin, E L; Yurkov, M V

    2001-01-01

    The exact solution of the eigenvalue equation for a high-gain FEL derived in Xie (Nucl. Instr. and Meth. A 445 (2000) 59) is generalized in order to include the space charge effects. This solution is valid not only for natural undulator focusing, but also for alternating-gradient focusing under some condition that is presented. At such, the obtained solution includes all the important effects in the system of axially homogeneous electron beam and undulator: diffraction, betatron motion, energy spread, space charge and frequency detuning. It is valid for ground TEM sub 0 sub 0 mode as well as for high-order modes and can be used for calculation of high-gain FEL amplifiers operating in the wavelength regions from far infrared down to X-ray. In addition, a computationally efficient approximate solution for TEM sub 0 sub 0 mode is derived providing high accuracy (better than 1% in the whole range of parameters). It can be used for quick optimization of FEL amplifiers.

  12. Broadband microwave phase shifter based on high speed cross gain modulation in quantum dot semiconductor optical amplifiers

    DEFF Research Database (Denmark)

    Chen, Yaohui; Mørk, Jesper

    2009-01-01

    We present a scheme to achieve tunable ~180 degrees microwave phase shifts at frequencies exceeding 100 GHz based on high speed cross gain modulation in quantum dot semiconductor optical amplifiers.......We present a scheme to achieve tunable ~180 degrees microwave phase shifts at frequencies exceeding 100 GHz based on high speed cross gain modulation in quantum dot semiconductor optical amplifiers....

  13. Whey protein reduces early life weight gain in mice fed a high-fat diet.

    Directory of Open Access Journals (Sweden)

    Britt Tranberg

    Full Text Available An increasing number of studies indicate that dairy products, including whey protein, alleviate several disorders of the metabolic syndrome. Here, we investigated the effects of whey protein isolate (whey in mice fed a high-fat diet hypothesising that the metabolic effects of whey would be associated with changes in the gut microbiota composition. Five-week-old male C57BL/6 mice were fed a high-fat diet ad libitum for 14 weeks with the protein source being either whey or casein. Faeces were collected at week 0, 7, and 13 and the fecal microbiota was analysed by denaturing gradient gel electrophoresis analyses of PCR-derived 16S rRNA gene (V3-region amplicons. At the end of the study, plasma samples were collected and assayed for glucose, insulin and lipids. Whey significantly reduced body weight gain during the first four weeks of the study compared with casein (P<0.001-0.05. Hereafter weight gain was similar resulting in a 15% lower final body weight in the whey group relative to casein (34.0±1.0 g vs. 40.2±1.3 g, P<0.001. Food intake was unaffected by protein source throughout the study period. Fasting insulin was lower in the whey group (P<0.01 and glucose clearance was improved after an oral glucose challenge (P<0.05. Plasma cholesterol was lowered by whey compared to casein (P<0.001. The composition of the fecal microbiota differed between high- and low-fat groups at 13 weeks (P<0.05 whereas no difference was seen between whey and casein. In conclusion, whey initially reduced weight gain in young C57BL/6 mice fed a high-fat diet compared to casein. Although the effect on weight gain ceased, whey alleviated glucose intolerance, improved insulin sensitivity and reduced plasma cholesterol. These findings could not be explained by changes in food intake or gut microbiota composition. Further studies are needed to clarify the mechanisms behind the metabolic effects of whey.

  14. Analysis of FEL-based CeC amplification at high gain limit

    Energy Technology Data Exchange (ETDEWEB)

    Wang, G. [Brookhaven National Lab. (BNL), Upton, NY (United States); Litvinenko, V. [Brookhaven National Lab. (BNL), Upton, NY (United States); Jing, Y. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-05-03

    An analysis of Coherent electron Cooling (CeC) amplifier based on 1D Free Electron Laser (FEL) theory was previously performed with exact solution of the dispersion relation, assuming electrons having Lorentzian energy distribution. At high gain limit, the asymptotic behavior of the FEL amplifier can be better understood by Taylor expanding the exact solution of the dispersion relation with respect to the detuning parameter. In this work, we make quadratic expansion of the dispersion relation for Lorentzian energy distribution and investigate how longitudinal space charge and electrons’ energy spread affect the FEL amplification process.

  15. High Gain Antenna System Deployment Mechanism Integration, Characterization, and Lessons Learned

    Science.gov (United States)

    Parong, Fil; Russell, Blair; Garcen, Walter; Rose, Chris; Johnson, Chris; Huber, Craig

    2014-01-01

    The integration and deployment testing of the High Gain Antenna System for the Global Precipitation Measurement mission is summarized. The HGAS deployment mechanism is described. The gravity negation system configuration and its influence on vertical, ground-based, deployment tests are presented with test data and model predictions. A focus is made on the late discovery and resolution of a potentially mission degrading deployment interference condition. The interaction of the flight deployment mechanism, gravity negation mechanism, and use of dynamic modeling is described and lessons learned presented.

  16. Influence of pre-pregnancy leisure time physical activity on gestational and postpartum weight gain and birth weight

    DEFF Research Database (Denmark)

    Hegaard, Hanne Kristine; Rode, Line; Katballe, Malene Kjær

    2017-01-01

    In order to examine the association between pre-pregnancy leisure time physical activities and gestational weight gain, postpartum weight gain and birth weight, we analysed prospectively collected data from 1827 women with singleton term pregnancies. Women were categorised in groups of sedentary...

  17. Photosynthetically active radiation and carbon gain drives the southern orientation of Myrtillocactus geometrizans fruits.

    Science.gov (United States)

    Ponce-Bautista, A; Valverde, P L; Flores, J; Zavala-Hurtado, A; Vite, F; López-Ortega, G; Pérez-Hernández, M A

    2017-03-01

    The equatorial orientation of reproductive structures is known in some columnar cacti from extratropical deserts. It has been hypothesised that photosynthetically active radiation (PAR) interception is the main reason for this orientation, because of its key effect on nocturnal CO2 uptake. However, there are no studies addressing both the effect of PAR and its consequence, carbon gain, on fruit orientation. Accordingly, we tested whether PAR and carbon gain could explain the southern fruit orientation of Myrtillocactus geometrizans, an inter-tropical columnar cactus. We studied three populations of M. geometrizans in Mexico. For each population, azimuth of fruits, total daily PAR, nocturnal acid accumulation (NAA) and fruit production were measured. The relationships between rib orientation and number of fruits, as well as total daily PAR, were evaluated using periodic regressions. The effect of total daily PAR and NAA on number of fruits was assessed using generalised linear models. During spring, mean fruit orientation had a south azimuth for three populations. Likewise, rib orientation had a significant effect on fruit production, with the south-facing ribs having the maximum number of fruits. Total daily PAR was highest in the south-facing ribs, at least for those in the northern and central populations. Furthermore, during spring, there was a significant positive effect of total daily PAR and NAA on fruit production. Our results provide strong evidence that the higher carbon gain in equatorial ribs, through a highest interception of PAR, would be the responsible factor for equatorial orientation of fruits in an inter-tropical columnar cactus.

  18. Monopole Charge Domain in High-Gain Gallium Arsenide Photoconductive Switches

    Institute of Scientific and Technical Information of China (English)

    施卫; 陈二柱; 张显斌; 李琦

    2002-01-01

    Considering that semi-insulating gallium arsenide photoconductive switches can be triggered into the high gain mode and no reliable theories can account for the observed transient characteristics, we propose the monopole charge domain model to explain the peculiar switching phenomena occurring in the high gain mode and we discuss the requirements for the lock-on switching. During operation on this mode, the applied field across the switch and the lock-on field are all larger than the Gunn threshold field. Our developed monopole charge domain is based on the transferred-electron effect, but the domain is only composed of large numbers of electrons piled up due to the negative differential mobility. Using the model and taking the physical mechanism of the avalanche impact ionization and recombination radiation into consideration, we interpret the typical phenomena of the lock-on effect, such as the time delay between the beginning of optical illumination and turning-on of the switch, and the conduction mechanism of the sustaining phase. Under different conditions of bias field intensity and incident light energy, the time delay of the switching is calculated. The results show that the physical mechanisms of impact ionization and recombination radiation occurring in the monopole charge domain are responsible for the lock-on switching.

  19. Polarization beam combination technique for gain saturation effect compensation in high-energy systems

    Science.gov (United States)

    Chen, Junchi; Peng, Yujie; Su, Hongpeng; Leng, Yuxin

    2016-06-01

    To compensate for the gain saturation effect in the high-energy laser amplifier, a modified polarization beam combination (PBC) method is introduced to reshape temporal waveform of the injected laser pulse to obtain a controlled high-energy laser pulse shape after amplification. One linearly polarized beam is divided into two orthogonal polarized beams, which spatially recombine together collinearly after propagating different optical paths with relative time delay in PBC structure. The obtained beam with polarization direction being rotated by the following half wave plate is divided and combined again to reform a new beam in another modified polarization beam structure. The reformed beam is injected into three cascaded laser amplifiers. The amplified pulse shape can be controlled by the incident pulse shape and amplifier gain, which is agreeable to the simulation by the Frank-Nodvik equations. Based on the simple method, the various temporal waveform of output pulse with tunable 7 to 20 ns pulse duration can be obtained without interferometric fringes.

  20. Inflection point caustic problems and solutions for high-gain dual-shaped reflectors

    Science.gov (United States)

    Galindo-Israel, Victor; Veruttipong, Thavath; Imbriale, William; Rengarajan, Sembiam

    1990-01-01

    The singular nature of the uniform geometrical theory of diffraction (UTD) subreflector scattered field at the vicinity of the main reflector edge (for a high-gain antenna design) is investigated. It is shown that the singularity in the UTD edge-diffracted and slope-diffracted fields is due to the reflection distance parameter approaching infinity in the transition functions. While the geometrical optics (GO) and UTD edge-diffracted fields exhibit singularities of the same order, the edge slope-diffracted field singularity is more significant and is substantial for greater subreflector edge tapers. The diffraction analysis of such a subreflector in the vicinity of the main reflector edge has been carried out efficiently and accurately by a stationary phase evaluation of the phi-integral, whereas the theta-integral is carried out numerically. Computational results from UTD and physical optics (PO) analysis of a 34-m ground station dual-shaped reflector confirm the analytical formulations for both circularly symmetric and offset asymmetric subreflectors. It is concluded that the proposed PO(theta)GO(phi) technique can be used to study the spillover or noise temperature characteristics of a high-gain reflector antenna efficiently and accurately.

  1. Study on laser characteristics of Ho:YLF regenerative amplifiers: Operation regimes, gain dynamics, and highly stable operation points

    Science.gov (United States)

    Kroetz, P.; Ruehl, A.; Calendron, A.-L.; Chatterjee, G.; Cankaya, H.; Murari, K.; Kärtner, F. X.; Hartl, I.; Miller, R. J. D.

    2017-04-01

    We present a comprehensive study of laser pulse amplification of Ho:YLF regenerative amplifiers (RAs) with respect to operation regimes, gain dynamics, and output pulse stability. The findings are expected to be more generic than for this specific gain material. Operation regimes are distinguished with respect to pulse energy and the appearance of pulse instability, and are studied as a function of the repetition rate, seed energy, and pump intensity. The corresponding gain dynamics are presented, identifying highly stable operation points related to high-gain build-up during pumping and high-gain depletion during pulse amplification. Such operation points are studied numerically and experimentally as a function of several parameters, thereby achieving, for our Ho:YLF RA, highly stable output pulses with measured fluctuations of only 0.19% (standard deviation).

  2. DFIG-Based Wind Turbine Robust Control Using High-Order Sliding Modes and a High Gain Observer

    OpenAIRE

    Beltran, Brice; Benbouzid, Mohamed; Ahmed-Ali, Tarek; Mangel, Hervé

    2011-01-01

    International audience; This paper deals with the power generation control in variable speed wind turbines. In this context, a control strategy is proposed to ensure power extraction optimization of a DFIG-based wind turbine. The proposed control strategy combines an MPPT using a high gain observer and second-order sliding mode for the DFIG control. This strategy presents attractive features such as chattering-free behavior, finite reaching time, robustness and unmodeled dynamics (generator a...

  3. The activity in the contralateral primary motor cortex, dorsal premotor and supplementary motor area is modulated by performance gains

    Directory of Open Access Journals (Sweden)

    Ronen eSosnik

    2014-04-01

    Full Text Available There is growing experimental evidence that the engagement of different brain areas in a given motor task may change with practice, although the specific brain activity patterns underlying different stages of learning, as defined by kinematic or dynamic performance indices, are not well understood. Here we studied the change in activation in motor areas during practice on sequences of handwriting-like trajectories, connecting four target points on a digitizing table 'as rapidly and as accurately as possible' while lying inside an fMRI scanner. Analysis of the subjects' pooled kinematic and imaging data, acquired at the beginning, middle and end of the training period, revealed no correlation between the amount of activation in the contralateral M1, PM (dorsal and ventral, SMA, preSMA and PPC and the amount of practice per-se. Single trial analysis has revealed that the correlation between the amount of activation in the contralateral M1 and trial mean velocity was partially modulated by performance gains related effects, such as increased hand motion smoothness. Furthermore, it was found that the amount of activation in the contralateral preSMA increased when subjects shifted from generating straight point-to-point trajectories to their spatiotemporal concatenation into a smooth, curved trajectory. Altogether, our results indicate that the amount of activation in the contralateral M1, PMd and preSMA during the learning of movement sequences is correlated with performance gains and that high level motion features (e.g., motion smoothness may modulate, or even mask correlations between activity changes and low-level motion attributes (e.g., trial mean velocity.

  4. Redesign of a Variable-Gain Output Feedback Longitudinal Controller Flown on the High-Alpha Research Vehicle (HARV)

    Science.gov (United States)

    Ostroff, Aaron J.

    1998-01-01

    This paper describes a redesigned longitudinal controller that flew on the High-Alpha Research Vehicle (HARV) during calendar years (CY) 1995 and 1996. Linear models are developed for both the modified controller and a baseline controller that was flown in CY 1994. The modified controller was developed with three gain sets for flight evaluation, and several linear analysis results are shown comparing the gain sets. A Neal-Smith flying qualities analysis shows that performance for the low- and medium-gain sets is near the level 1 boundary, depending upon the bandwidth assumed, whereas the high-gain set indicates a sensitivity problem. A newly developed high-alpha Bode envelope criterion indicates that the control system gains may be slightly high, even for the low-gain set. A large motion-base simulator in the United Kingdom was used to evaluate the various controllers. Desired performance, which appeared to be satisfactory for flight, was generally met with both the low- and medium-gain sets. Both the high-gain set and the baseline controller were very sensitive, and it was easy to generate pilot-induced oscillation (PIO) in some of the target-tracking maneuvers. Flight target-tracking results varied from level 1 to level 3 and from no sensitivity to PIO. These results were related to pilot technique and whether actuator rate saturation was encountered.

  5. Whey protein reduces early life weight gain in mice fed a high-fat diet

    DEFF Research Database (Denmark)

    Tranberg, Britt; Hellgren, Lars; Lykkesfeldt, Jens;

    2013-01-01

    be associated with changes in the gut microbiota composition. Five-week-old male C57BL/6 mice were fed a high-fat diet ad libitum for 14 weeks with the protein source being either whey or casein. Faeces were collected at week 0, 7, and 13 and the fecal microbiota was analysed by denaturing gradient gel...... weight gain was similar resulting in a 15% lower final body weight in the whey group relative to casein (34.0±1.0 g vs. 40.2±1.3 g, PFasting insulin was lower in the whey group (P... after an oral glucose challenge (Pmicrobiota differed between high- and low-fat groups at 13 weeks (P

  6. Millimeter-wave double-dipole antennas for high-gain integrated reflector illumination

    Science.gov (United States)

    Filipovic, Daniel F.; Ali-Ahmad, Walid Y.; Rebeiz, Gabriel M.

    1992-05-01

    A double-dipole antenna backed by a ground plane has been fabricated for submillimeter wavelengths. The double-dipole antenna is integrated on a thin dielectric membrane with a planar detector at its center. Measured feed patterns at 246 GHz agree well with theory and demonstrate a rotationally symmetric pattern with high coupling efficiency to Gaussian beams. The input impedance is around 50 ohms, and will match well to a Schottky diode or SIS detector. The double-dipole antenna served as the feed for a small machined parabolic reflector. The integrated reflector had a measured gain of 37 dB at 119 microns. This makes the double-dipole antenna ideally suited as a feed for high resolution tracking or for long focal length Cassegrain antenna systems.

  7. Whey protein reduces early life weight gain in mice fed a high-fat diet

    DEFF Research Database (Denmark)

    Tranberg, Britt; Hellgren, Lars; Lykkesfeldt, Jens

    2013-01-01

    An increasing number of studies indicate that dairy products, including whey protein, alleviate several disorders of the metabolic syndrome. Here, we investigated the effects of whey protein isolate (whey) in mice fed a high-fat diet hypothesising that the metabolic effects of whey would...... be associated with changes in the gut microbiota composition. Five-week-old male C57BL/6 mice were fed a high-fat diet ad libitum for 14 weeks with the protein source being either whey or casein. Faeces were collected at week 0, 7, and 13 and the fecal microbiota was analysed by denaturing gradient gel...... weight gain was similar resulting in a 15% lower final body weight in the whey group relative to casein (34.0±1.0 g vs. 40.2±1.3 g, Pprotein source throughout the study period. Fasting insulin was lower in the whey group (P

  8. High Gain Slot Array with Fabry-Perot Cavity Feeding Circuit

    Directory of Open Access Journals (Sweden)

    Halim Boutayeb

    2016-01-01

    Full Text Available A new approach for designing slot arrays using a Fabry-Perot cavity for the feeding circuit is presented. The proposed array has simpler and smaller feeding circuit compared to conventional feeding networks that have multiple dividers or combiners. The dividers and combiners are usually sources of losses. In addition, the profile of the proposed array is not limited by the half-wavelength resonance condition that exists for Fabry-Perot resonator antennas based on partially reflecting surfaces. The operating frequency is not sensitive to the profile of the antenna. A small profile can be achieved without the utilization of an artificial magnetic conductor or a substrate with high dielectric constant. To validate the proposed approach, full-wave numerical results are presented at 5.8 GHz showing good impedance matching, a high gain of about 22 dB, and an efficiency of 76%.

  9. Indirect flat-panel detector with avalanche gain: fundamental feasibility investigation for SHARP-AMFPI (scintillator HARP active matrix flat panel imager).

    Science.gov (United States)

    Zhao, Wei; Li, Dan; Reznik, Alla; Lui, B J M; Hunt, D C; Rowlands, J A; Ohkawa, Yuji; Tanioka, Kenkichi

    2005-09-01

    An indirect flat-panel imager (FPI) with avalanche gain is being investigated for low-dose x-ray imaging. It is made by optically coupling a structured x-ray scintillator CsI(Tl) to an amorphous selenium (a-Se) avalanche photoconductor called HARP (high-gain avalanche rushing photoconductor). The final electronic image is read out using an active matrix array of thin film transistors (TFT). We call the proposed detector SHARP-AMFPI (scintillator HARP active matrix flat panel imager). The advantage of the SHARP-AMFPI is its programmable gain, which can be turned on during low dose fluoroscopy to overcome electronic noise, and turned off during high dose radiography to avoid pixel saturation. The purpose of this paper is to investigate the important design considerations for SHARP-AMFPI such as avalanche gain, which depends on both the thickness d(Se) and the applied electric field E(Se) of the HARP layer. To determine the optimal design parameter and operational conditions for HARP, we measured the E(Se) dependence of both avalanche gain and optical quantum efficiency of an 8 microm HARP layer. The results were used in a physical model of HARP as well as a linear cascaded model of the FPI to determine the following x-ray imaging properties in both the avalanche and nonavalanche modes as a function of E(Se): (1) total gain (which is the product of avalanche gain and optical quantum efficiency); (2) linearity; (3) dynamic range; (4) gain nonuniformity resulting from thickness nonuniformity; and (5) effects of direct x-ray interaction in HARP. Our results showed that a HARP layer thickness of 8 microm can provide adequate avalanche gain and sufficient dynamic range for x-ray imaging applications to permit quantum limited operation over the range of exposures needed for radiography and fluoroscopy.

  10. Small sized high-gain PHEMT high-power amplifiers for X-band applications

    NARCIS (Netherlands)

    Hek, A.P. de; Hunneman, P.A.H.

    2000-01-01

    The development of two small sized broadband X-band high-power amplifiers is discussed. The amplifiers are realised with the help of the pseudomorphic HEMT technology of the Fraunhofer Institute for Applied Solid State Physics (FhG-IAF). With the help of this technology the feasibility of

  11. Small sized high-gain PHEMT high-power amplifiers for X-band applications

    NARCIS (Netherlands)

    Hek, A.P. de; Hunneman, P.A.H.

    2000-01-01

    The development of two small sized broadband X-band high-power amplifiers is discussed. The amplifiers are realised with the help of the pseudomorphic HEMT technology of the Fraunhofer Institute for Applied Solid State Physics (FhG-IAF). With the help of this technology the feasibility of integratin

  12. High-pass filtering and dynamic gain regulation enhance vertical bursts transmission along the mossy fiber pathway of cerebellum

    Directory of Open Access Journals (Sweden)

    Jonathan Mapelli

    2010-05-01

    Full Text Available Signal elaboration in the cerebellum mossy fiber input pathway presents controversial aspects, especially concerning gain regulation and the spot-like (rather than beam-like appearance of granular-to-molecular layer transmission. By using voltage-sensitive dye (VSD imaging in rat cerebellar slices (Mapelli et al., 2010, we found that mossy fiber bursts optimally excited the granular layer above ~50 Hz and the overlaying molecular layer above ~100 Hz, thus generating a cascade of high-pass filters. NMDA receptors enhanced transmission in the granular, while GABA-A receptors depressed transmission in both the granular and molecular layer. Burst transmission gain was controlled through a dynamic frequency-dependent involvement of these receptors. Moreover, while high-frequency transmission was enhanced along vertical lines connecting the granular to molecular layer, no high-frequency enhancement was observed along the parallel fiber axis in the molecular layer. This was probably due to the stronger effect of Purkinje cell GABA-A receptor-mediated inhibition occurring along the parallel fibers than along the granule cell axon ascending branch. The consequent amplification of burst responses along vertical transmission lines could explain the spot-like activation of Purkinje cells observed following punctuate stimulation in vivo .

  13. Thermoregulation of water foraging honeybees—Balancing of endothermic activity with radiative heat gain and functional requirements

    Science.gov (United States)

    Kovac, Helmut; Stabentheiner, Anton; Schmaranzer, Sigurd

    2010-01-01

    Foraging honeybees are subjected to considerable variations of microclimatic conditions challenging their thermoregulatory ability. Solar heat is a gain in the cold but may be a burden in the heat. We investigated the balancing of endothermic activity with radiative heat gain and physiological functions of water foraging Apis mellifera carnica honeybees in the whole range of ambient temperatures (Ta) and solar radiation they are likely to be exposed in their natural environment in Middle Europe. The mean thorax temperature (Tth) during foraging stays was regulated at a constantly high level (37.0–38.5 °C) in a broad range of Ta (3–30 °C). At warmer conditions (Ta = 30–39 °C) Tth increased to a maximal level of 45.3 °C. The endothermic temperature excess (difference of Tbody − Ta of living and dead bees) was used to assess the endogenously generated temperature elevation as a correlate of energy turnover. Up to a Ta of ∼30 °C bees used solar heat gain for a double purpose: to reduce energetic expenditure and to increase Tth by about 1–3 °C to improve force production of flight muscles. At higher Ta they exhibited cooling efforts to get rid of excess heat. A high Tth also allowed regulation of the head temperature high enough to guarantee proper function of the bees’ suction pump even at low Ta. This shortened the foraging stays and this way reduced energetic costs. With decreasing Ta bees also reduced arrival body weight and crop loading to do both minimize costs and optimize flight performance. PMID:20705071

  14. Progress in laboratory high gain ICF (inertial confinement fusion): Prospects for the future

    Energy Technology Data Exchange (ETDEWEB)

    Storm, E.; Lindl, J.D.; Campbell, E.M.; Bernat, T.P.; Coleman, L.W.; Emmett, J.L.; Hogan, W.J.; Hunt, J.T.; Krupke, W.F.; Lowdermilk, W.H.

    1988-01-01

    Inertial confinement fusion (ICF), a thermonuclear reaction in a small (/approximately/5 mm diameter) fuel capsule filled with a few milligrams of deuterium and tritium, has been the subject of very fruitful experimentation since the early 1970's. High gain ICF is now on the threshold of practical applications. With a Laboratory Microfusion Facility (LMF), these applications will have major implications for national defense, basic and applied science, and power production. With a driver capable of delivering about 10 MJ in a 10-ns pulse at an intensity of /approximately/3 /times/ 10/sup 14/ W/cm/sup 2/, an appropriately configured cryogenic capsule could be compressed to a density of about 200 g/cm/sup 3/ and a temperature of 3--5 keV. Under these conditions, up to 10 mg of DT could be ignited, and with a burn efficiency of about 30%, release up to 1000 MJ of fusion energy, an energy gain of about 100. A thousand megajoules is equivalent to about one quarter ton of TNT, or about 7 gallons of oil--an amount of energy tractable under laboratory conditions and potentially very useful for a variety of applications. 61 refs., 33 figs.

  15. Storage and retrieval of light pulses in a fast-light medium via active Raman gain

    Science.gov (United States)

    Xu, Datang; Bai, Zhengyang; Huang, Guoxiang

    2016-12-01

    We propose a scheme to realize the storage and retrieval of light pulses in a fast-light medium via a mechanism of active Raman gain (ARG). The system under consideration is a four-level atomic gas interacting with three (pump, signal, and control) laser fields. We show that a stable propagation of signal light pulses with superluminal velocity (i.e., fast-light pulses) is possible in such a system through the ARG contributed by the pump field and the quantum interference effect induced by the control field. We further show that a robust storage and retrieval of light pulses in such a fast-light medium can be implemented by switching on and off the pump and the control fields simultaneously. The results reported here may have potential applications for light information processing and transmission using fast-light media.

  16. Lossless Airy Surface Polaritons in a Metamaterial via Active Raman Gain

    CERN Document Server

    Zhang, Qi; Huang, Guoxiang

    2016-01-01

    We propose a scheme to realize a lossless propagation of linear and nonlinear Airy surface polaritons (SPs) via active Raman gain (ARG). The system we suggest is a planar interface superposed by a negative index metamaterial (NIMM) and a dielectric, where three-level quantum emitters are doped. By using the ARG from the quantum emitters and the destructive interference effect between the electric and magnetic responses from the NIMM, we show that not only the Ohmic loss of the NIMM but also the light absorption of the quantum emitters can be completely eliminated. As a result, non-diffractive Airy SPs may propagate for very long distance without attenuation. We also show that the Kerr nonlinearity of the system can be largely enhanced due to the introduction of the quantum emitters and hence lossless Airy surface polaritonic solitons with very low power can be generated in the system.

  17. Lossless Airy Surface Polaritons in a Metamaterial via Active Raman Gain.

    Science.gov (United States)

    Zhang, Qi; Tan, Chaohua; Huang, Guoxiang

    2016-02-19

    We propose a scheme to realize a lossless propagation of linear and nonlinear Airy surface polaritons (SPs) via active Raman gain (ARG). The system we suggest is a planar interface superposed by a negative index metamaterial (NIMM) and a dielectric, where three-level quantum emitters are doped. By using the ARG from the quantum emitters and the destructive interference effect between the electric and magnetic responses from the NIMM, we show that not only the Ohmic loss of the NIMM but also the light absorption of the quantum emitters can be completely eliminated. As a result, non-diffractive Airy SPs may propagate for very long distance without attenuation. We also show that the Kerr nonlinearity of the system can be largely enhanced due to the introduction of the quantum emitters and hence lossless Airy surface polaritonic solitons with very low power can be generated in the system.

  18. Actively phase-controlled coupling between plasmonic waveguides via in-between gain-assisted nanoresonator: nanoscale optical logic gates.

    Science.gov (United States)

    Ho, Kum-Song; Han, Yong-Ha; Ri, Chol-Song; Im, Song-Jin

    2016-08-15

    The development of nanoscale optical logic gates has attracted immense attention due to increasing demand for ultrahigh-speed and energy-efficient optical computing and data processing, however, suffers from the difficulty in precise control of phase difference of the two optical signals. We propose a novel conception of nanoscale optical logic gates based on actively phase-controlled coupling between two plasmonic waveguides via an in-between gain-assisted nanoresonator. Precise control of phase difference between the two plasmonic signals can be performed by manipulating pumping rate at an appropriate frequency detuning, enabling a high contrast between the output logic states "1" and "0." Without modification of the structural parameters, different logic functions can be provided. This active nanoscale optical logic device is expected to be quite energy-efficient with ideally low energy consumption on the order of 0.1 fJ/bit. Analytical calculations and numerical experiments demonstrate the validity of the proposed concept.

  19. High-gain Seeded FEL Amplifier Tunable in the Terahertz Range

    CERN Document Server

    Sung, C; Pellegrini, C; Ralph, J E; Reiche, S; Rosenzweig, J B; Tochitsky, Sergei Ya

    2005-01-01

    The lack of a high-power, relatively low-cost and compact terahertz (THz) source in the range 0.3-3x10(12) Hz is the major obstacle in progressing on biomedical and material studies at these wavelengths. A high-gain, single pass seeded FEL technique allows to obtain high power THz pulses of a high spectral brightness. We describe an ongoing project at the Neptune laboratory where a ~ 1kW seed pulse generated by difference frequency mixing of CO2 laser lines in a GaAs nonlinear crystal is injected into a waveguide FEL amplifier. The FEL is driven by a 5 ps (r.m.s) long electron pulse with a peak current up to 100A provided by a regular S-band photoinjector. According to 3-D, time dependent simulations, up to ~ 10 MW THz power can be generated using a 2 meter long planar undulator. By mixing different pairs of CO2 laser lines and matching resonant energy of the electron beam, tunability in the 100-400 mm range is expected. A tunable Fabri-Perot interferometer will be used to select a high-power 5ps THz pulse. T...

  20. Telomerase activation in posterior fossa group A ependymomas is associated with dismal prognosis and chromosome 1q gain.

    Science.gov (United States)

    Gojo, Johannes; Lötsch, Daniela; Spiegl-Kreinecker, Sabine; Pajtler, Kristian W; Neumayer, Katharina; Korbel, Pia; Araki, Asuka; Brandstetter, Anita; Mohr, Thomas; Hovestadt, Volker; Chavez, Lukas; Kirchhofer, Dominik; Ricken, Gerda; Stefanits, Harald; Korshunov, Andrey; Pfister, Stefan M; Dieckmann, Karin; Azizi, Amedeo A; Czech, Thomas; Filipits, Martin; Kool, Marcel; Peyrl, Andreas; Slavc, Irene; Berger, Walter; Haberler, Christine

    2017-09-01

    Ependymomas account for up to 10% of childhood CNS tumors and have a high rate of tumor recurrence despite gross total resection. Recently, classification into molecular ependymoma subgroups has been established, but the mechanisms underlying the aggressiveness of certain subtypes remain widely enigmatic. The aim of this study was to dissect the clinical and biological role of telomerase reactivation, a frequent mechanism of cancer cells to evade cellular senescence, in pediatric ependymoma. We determined telomerase enzymatic activity, hTERT mRNA expression, promoter methylation, and the rs2853669 single nucleotide polymorphism located in the hTERT promoter in a well-characterized cohort of pediatric intracranial ependymomas. In posterior fossa ependymoma group A (PF-EPN-A) tumors, telomerase activity varied and was significantly associated with dismal overall survival, whereas telomerase reactivation was present in all supratentorial RelA fusion-positive (ST-EPN-RELA) ependymomas. In silico analysis of methylation patterns showed that only these two subgroups harbor hypermethylated hTERT promoters suggesting telomerase reactivation via epigenetic mechanisms. Furthermore, chromosome 1q gain, a well-known negative prognostic factor, was strongly associated with telomerase reactivation in PF-EPN-A. Additional in silico analyses of gene expression data confirmed this finding and further showed enrichment of the E-twenty-six factor, Myc, and E2F target genes in 1q gained ependymomas. Additionally, 1q gained tumors showed elevated expression of ETV3, an E-twenty-six factor gene located on chromosome 1q. Taken together we describe a subgroup-specific impact of telomerase reactivation on disease progression in pediatric ependymoma and provide preliminary evidence for the involved molecular mechanisms.

  1. High gain harmonic generation free electron lasers enhanced by pseudoenergy bands

    Directory of Open Access Journals (Sweden)

    Takashi Tanaka

    2017-08-01

    Full Text Available We propose a new scheme for high gain harmonic generation free electron lasers (HGHG FELs, which is seeded by a pair of intersecting laser beams to interact with an electron beam in a modulator undulator located in a dispersive section. The interference of the laser beams gives rise to a two-dimensional modulation in the energy-time phase space because of a strong correlation between the electron energy and the position in the direction of dispersion. This eventually forms pseudoenergy bands in the electron beam, which result in efficient harmonic generation in HGHG FELs in a similar manner to the well-known scheme using the echo effects. The advantage of the proposed scheme is that the beam quality is less deteriorated than in other existing schemes.

  2. A high gain patch fed horn antenna for millimeter wave imaging receiver

    Science.gov (United States)

    Shireen, Rownak; Hwang, Timothy; Shi, Shouyuan; Prather, D. W.

    2005-11-01

    In this paper, antennas that combine transitions from microstrip line / coplanar waveguide (CPW) to horn antenna in a single unit are presented. Conventional single layer microstrip patch antennas inherently suffer narrow operation bandwidth; to widen the frequency bandwidth, stacked patch antennas are used and high gain is achieved from the horn antenna. Here, microstrip line / CPW directly feeds the bottom patch while the top patch couples parasitically to the bottom patch. For -10 dB return loss, 25% bandwidth is achieved for both microstrip line to horn antenna (MSLTHA) at center frequency f0=17.5 GHz and for CPW to horn antenna (CPWTHA) at f0=97 GHz. The designs were optimized using 3D Finite Element Method (FEM) software HFSS by Ansoft Corporation. The optimal design of MSLTHA has been fabricated and characterized. The return loss and far field radiation pattern are measured and has been found in very good agreement with the simulation results.

  3. Photovoltaic Response Characteristics of GaAs Photoconductive Switches Under High Gain Mode

    Institute of Scientific and Technical Information of China (English)

    DAI Hui-ying; SHI Wei

    2007-01-01

    Given is the experiment results in which the laser pulses of 1 046 nm and 532 nm are used to trigger the semi-insulation GaAs photoconductive semiconductor switch(PCSS) with an electrode distance of 4 mm. And made is an analysis of the switch's photovoltaic response characteristics under the high gain mode when the biased field is bigger than the Geng effect field. Also a theory is presented that the main reason for the photovoltaic pulse response delay is the transmission of charge domain, caused by the presence of EL2 energy level in the chip material. Finally, the transmission time of charge domain is calculated and a result that inosculates with the experiment is attained.

  4. High gain harmonic generation free electron lasers enhanced by pseudoenergy bands

    Science.gov (United States)

    Tanaka, Takashi; Kinjo, Ryota

    2017-08-01

    We propose a new scheme for high gain harmonic generation free electron lasers (HGHG FELs), which is seeded by a pair of intersecting laser beams to interact with an electron beam in a modulator undulator located in a dispersive section. The interference of the laser beams gives rise to a two-dimensional modulation in the energy-time phase space because of a strong correlation between the electron energy and the position in the direction of dispersion. This eventually forms pseudoenergy bands in the electron beam, which result in efficient harmonic generation in HGHG FELs in a similar manner to the well-known scheme using the echo effects. The advantage of the proposed scheme is that the beam quality is less deteriorated than in other existing schemes.

  5. CLOSED LOOP CONTROL OF THREE PORT CONVERTER WITH HIGH VOLTAGE GAIN

    Directory of Open Access Journals (Sweden)

    Santhi Mary Antony A

    2015-08-01

    Full Text Available Photovoltaic (PV system is one of the best renewable energy sources for power generation system due to their pollution free and low cost properties. The PV cells has less efficiency compared to other source of power generation. The system efficiency is improved by reducing components count, which reduces the losses. In this paper a new three port converter (TPC is proposed for stand-alone renewable power applications. The proposed converter has three switches to achieve the power flow control. Single inductor is used for common energy transfer element for two different sources. The coupled inductor is used to increase the voltage conversion ratio with reasonable duty cycle. Thus the proposed converter has high voltage gain with less components count. The output voltage is regulated through feedback network. The system performance is verified through simulation results.

  6. Spectral Phase Modulation and chirped pulse amplification in High Gain Harmonic Generation

    CERN Document Server

    Wu, Zilu; Krinsky, Sam; Loos, Henrik; Murphy, James; Shaftan, Timur; Sheehy, Brian; Shen, Yuzhen; Wang, Xijie; Yu Li Hua

    2004-01-01

    High Gain Harmonic Generation (HGHG), because it produces longitudinally coherent pulses derived from a coherent seed, presents remarkable possibilities for manipulating FEL pulses. If spectral phase modulation imposed on the seed modulates the spectral phase of the HGHG in a deterministic fashion, then chirped pulse amplification, pulse shaping, and coherent control experiments at short wavelengths become possible. In addition, the details of the transfer function will likely depend on electron beam and radiator dynamics and so prove to be a useful tool for studying these. Using the DUVFEL at the National Synchrotron Light Source at Brookhaven National Laboratory, we present spectral phase analyses of both coherent HGHG and incoherent SASE ultraviolet FEL radiation, applying Spectral Interferometry for Direct Electric Field Reconstruction (SPIDER), and assess the potential for employing compression and shaping techniques.

  7. Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice

    DEFF Research Database (Denmark)

    Madsen, Birgitte Lindegaard; Matthews, Vance B; Brandt, Claus

    2013-01-01

    Circulating interleukin (IL)-18 is elevated in obesity, but paradoxically causes hypophagia. We hypothesized that IL-18 may attenuate high fat diet induced insulin resistance by activating AMP activated protein kinase (AMPK). We studied mice with a global deletion of the α isoform of the IL-18...

  8. A new simpler way to obtain high fusion power gain in tandem mirrors

    Science.gov (United States)

    Fowler, T. K.; Moir, R. W.; Simonen, T. C.

    2017-05-01

    From the earliest days of fusion research, Richard F. Post and other advocates of magnetic mirror confinement recognized that mirrors favor high ion temperatures where nuclear reaction rates begin to peak for all fusion fuels. In this paper we review why high ion temperatures are favored, using Post’s axisymmetric Kinetically Stabilized Tandem Mirror as the example; and we offer a new idea that appears to greatly improve reactor prospects at high ion temperatures. The idea is, first, to take advantage of recent advances in superconducting magnet technology to minimize the size and cost of End Plugs; and secondly, to utilize parallel advances in gyrotrons that would enable intense electron cyclotron heating (ECH) in these high field End Plugs. The yin-yang magnets and thermal barriers that complicated earlier tandem mirror designs are not required. We find that, concerning end losses, intense ECH in symmetric End Plugs could increase the fusion power gain Q, for both DT and Catalyzed DD fuel cycles, to levels competitive with steady-state tokamaks burning DT fuel. Radial losses remain an issue that will ultimately determine reactor viability.

  9. Convergent Evolution towards High Net Carbon Gain Efficiency Contributes to the Shade Tolerance of Palms (Arecaceae).

    Science.gov (United States)

    Ma, Ren-Yi; Zhang, Jiao-Lin; Cavaleri, Molly A; Sterck, Frank; Strijk, Joeri S; Cao, Kun-Fang

    2015-01-01

    Most palm species occur in the shaded lower strata of tropical rain forests, but how their traits relate to shade adaptation is poorly understood. We hypothesized that palms are adapted to the shade of their native habitats by convergent evolution towards high net carbon gain efficiency (CGEn), which is given by the maximum photosynthetic rate to dark respiration rate ratio. Leaf mass per area, maximum photosynthetic rate, dark respiration and N and P concentrations were measured in 80 palm species grown in a common garden, and combined with data of 30 palm species growing in their native habitats. Compared to other species from the global leaf economics data, dicotyledonous broad-leaved trees in tropical rainforest or other monocots in the global leaf economics data, palms possessed consistently higher CGEn, achieved by lowered dark respiration and fairly high foliar P concentration. Combined phylogenetic analyses of evolutionary signal and trait evolution revealed convergent evolution towards high CGEn in palms. We conclude that high CGEn is an evolutionary strategy that enables palms to better adapt to shady environments than coexisting dicot tree species, and may convey advantages in competing with them in the tropical forest understory. These findings provide important insights for understanding the evolution and ecology of palms, and for understanding plant shade adaptations of lower rainforest strata. Moreover, given the dominant role of palms in tropical forests, these findings are important for modelling carbon and nutrient cycling in tropical forest ecosystems.

  10. Convergent Evolution towards High Net Carbon Gain Efficiency Contributes to the Shade Tolerance of Palms (Arecaceae.

    Directory of Open Access Journals (Sweden)

    Ren-Yi Ma

    Full Text Available Most palm species occur in the shaded lower strata of tropical rain forests, but how their traits relate to shade adaptation is poorly understood. We hypothesized that palms are adapted to the shade of their native habitats by convergent evolution towards high net carbon gain efficiency (CGEn, which is given by the maximum photosynthetic rate to dark respiration rate ratio. Leaf mass per area, maximum photosynthetic rate, dark respiration and N and P concentrations were measured in 80 palm species grown in a common garden, and combined with data of 30 palm species growing in their native habitats. Compared to other species from the global leaf economics data, dicotyledonous broad-leaved trees in tropical rainforest or other monocots in the global leaf economics data, palms possessed consistently higher CGEn, achieved by lowered dark respiration and fairly high foliar P concentration. Combined phylogenetic analyses of evolutionary signal and trait evolution revealed convergent evolution towards high CGEn in palms. We conclude that high CGEn is an evolutionary strategy that enables palms to better adapt to shady environments than coexisting dicot tree species, and may convey advantages in competing with them in the tropical forest understory. These findings provide important insights for understanding the evolution and ecology of palms, and for understanding plant shade adaptations of lower rainforest strata. Moreover, given the dominant role of palms in tropical forests, these findings are important for modelling carbon and nutrient cycling in tropical forest ecosystems.

  11. A High Efficiency Variable Gain Amplifier Circuit with Controllable Transconductance Amp

    Science.gov (United States)

    Okura, Tetsuro; Okura, Shunsuke; Ido, Toru; Taniguchi, Kenji

    A novel power reduction technique for a variable gain amplifier (VGA) with a two-stage operational amplifier is proposed. The technique improves the power consumption of a VGA by optimizing the bandwidth and the phase margin dynamically on all gain range of the VGA through controlling the input transconductance of opamp. A VGA utilizing the proposed technique shows 40% reduction of power consumption against a conventional VGA at the best condition of VGA gain range.

  12. Transgenic Rescue of Adipocyte Glucose-dependent Insulinotropic Polypeptide Receptor Expression Restores High Fat Diet-induced Body Weight Gain

    DEFF Research Database (Denmark)

    Ugleholdt, Randi; Pedersen, Jens; Bassi, Maria Rosaria

    2011-01-01

    to adipose tissue have a similar high fat diet -induced body weight gain as control mice, significantly greater than the weight gain in mice with a general ablation of the receptor. Surprisingly, this difference was due to an increase in total lean body mass rather than a gain in total fat mass......The glucose-dependent insulinotropic polypeptide receptor (GIPr) has been implicated in high fat diet-induced obesity and is proposed as an anti-obesity target despite an uncertainty regarding the mechanism of action. To independently investigate the contribution of the insulinotropic effects...

  13. Fluorene- and benzofluorene-cored oligomers as low threshold and high gain amplifying media

    Energy Technology Data Exchange (ETDEWEB)

    Kazlauskas, Karolis, E-mail: karolis.kazlauskas@ff.vu.lt; Kreiza, Gediminas; Bobrovas, Olegas; Adomėnienė, Ona; Adomėnas, Povilas; Juršėnas, Saulius [Institute of Applied Research, Vilnius University, Saulėtekio 9-III, LT-10222 Vilnius (Lithuania); Jankauskas, Vygintas [Department of Solid State Electronics, Vilnius University, Saulėtekio 9-III, LT-10222 Vilnius (Lithuania)

    2015-07-27

    Deliberate control of intermolecular interactions in fluorene- and benzofluorene-cored oligomers was attempted via introduction of different-length alkyl moieties to attain high emission amplification and low amplified spontaneous emission (ASE) threshold at high oligomer concentrations. Containing fluorenyl peripheral groups decorated with different-length alkyl moieties, the oligomers were found to express weak concentration quenching of emission, yet excellent carrier drift mobilities (close to 10{sup −2} cm{sup 2}/V/s) in the amorphous films. Owing to the larger radiative decay rates (>1.0 × 10{sup 9 }s{sup −1}) and smaller concentration quenching, fluorene-cored oligomers exhibited down to one order of magnitude lower ASE thresholds at higher concentrations as compared to those of benzofluorene counterparts. The lowest threshold (300 W/cm{sup 2}) obtained for the fluorene-cored oligomers at the concentration of 50 wt % in polymer matrix is among the lowest reported for solution-processed amorphous films in ambient conditions, what makes the oligomers promising for lasing application. Great potential in emission amplification was confirmed by high maximum net gain (77 cm{sup −1}) revealed for these compounds. Although the photostability of the oligomers was affected by photo-oxidation, it was found to be comparable to that of various organic lasing materials including some commercial laser dyes evaluated under similar excitation conditions.

  14. Lean rats gained more body weight than obese ones from a high-fibre diet.

    Science.gov (United States)

    Li, Shaoting; Zhang, Cheng; Gu, Yingyi; Chen, Long; Ou, Shiyi; Wang, Yong; Peng, Xichun

    2015-10-28

    There is controversy over previous findings that a high ratio of Firmicutes to Bacteriodetes helps obese animals harvest energy from the diet. To further investigate the relationship between microbial composition and energy harvest, microbial adaptation to diet and time should be considered. In this study, lean and obese rats were successfully induced with low-fat and high-fat diets. An 8-week high soyabean fibre (HSF)-containing diet was then fed to investigate the interaction between the diet and the rats' gut microbiota, as well as their influence on rats' growth. Rats' body weight (BW) was recorded weekly; their plasma lipids and their gut microbiota at week 11, 15 and 19 were analysed. After the consumption of the HSF diet, BW of lean rats increased significantly (Pdiet. There was no significant difference observed at each period between lean and obese rats. In the group of lean rats, the diversity of gut microbiota was elevated strongly (Pdiet control. In conclusion, the increased Firmicutes and Bacteriodetes might relate to lean rats' higher BW gain; 'obese microbiota' could not help the hosts harvest more energy from the HSF diet.

  15. Relationship between sociodemographics, dietary intake, and physical activity with gestational weight gain among pregnant women in Rafsanjan City, Iran.

    Science.gov (United States)

    Ebrahimi, Fatemeh; Shariff, Zalilah Mohd; Tabatabaei, Seyed Zia; Fathollahi, Mahmood Sheikh; Mun, Chan Yoke; Nazari, Mozhgan

    2015-03-01

    Gestational weight gain (GWG) is a determinant of health and nutrition of mothers and offspring. However, many factors associated with GWG are not completely understood. The present study assessed the relationship between sociodemographics, dietary intake, and physical activity with GWG in 308 Iranian pregnant women attending government healthcare centres in Rafsanjan city, Iran. Women gained an average of 12.87±3.57 kg during pregnancy while 54% did not gain weight within the Institute of Medicine (IOM)-recommended range. Univariate logistic models showed that gestaional weight gain was related to age, pre-pregnancy body mass index (BMI), energy intake, and sitting time. Cumulative logit model showed positive relationship between age (p=0.0137) and pre-pregnancy BMI (pnutritional status and physical activity should be emphasized in antenatal care.

  16. Fusing Passive and Active Sensed Images to Gain Infrared-Textured 3d Models

    Science.gov (United States)

    Weinmann, M.; Hoegner, L.; Leitloff, J.; Stilla, U.; Hinz, S.; Jutzi, B.

    2012-07-01

    Obtaining a 3D description of man-made and natural environments is a basic task in Computer Vision, Photogrammetry and Remote Sensing. New active sensors provide the possibility of capturing range information by images with a single measurement. With this new technique, image-based active ranging is possible which allows for capturing dynamic scenes, e.g. with moving pedestrians or moving vehicles. The currently available range imaging devices usually operate within the close-infrared domain to capture range and furthermore active and passive intensity images. Depending on the application, a 3D description with additional spectral information such as thermal-infrared data can be helpful and offers new opportunities for the detection and interpretation of human subjects and interactions. Therefore, thermal-infrared data combined with range information is promising. In this paper, an approach for mapping thermal-infrared data on range data is proposed. First, a camera calibration is carried out for the range imaging system (PMD[vision] CamCube 2.0) and the thermal-infrared system (InfraTec VarioCAM hr). Subsequently, a registration of close-infrared and thermal infrared intensity images derived from different sensor devices is performed. In this context, wavelength independent properties are selected in order to derive point correspondences between the different spectral domains. Finally, the thermal infrared images are enhanced with information derived from data acquired with the range imaging device and the enhanced IR texture is projected onto the respective 3D point cloud data for gaining appropriate infrared-textured 3D models. The feasibility of the proposed methodology is demonstrated for an experimental setup which is well-suited for investigating these proposed possibilities. Hence, the presented work is a first step towards the development of methods for combined thermal-infrared and range representation.

  17. Gestational weight gain by reduced brain melanocortin activity affects offspring energy balance in rats

    NARCIS (Netherlands)

    Heinsbroek, A. C. M.; van Dijk, G.

    2009-01-01

    Introduction: Excessive gestational body weight gain of mothers may predispose offspring towards obesity and metabolic derangements. It is difficult to discern the effects of maternal obesogenic factors-such as diet and/or thrifty genetic predisposition-from gestational weight gain per se. Methods:

  18. A scalable-low cost architecture for high gain beamforming antennas

    KAUST Repository

    Bakr, Omar

    2010-10-01

    Many state-of-the-art wireless systems, such as long distance mesh networks and high bandwidth networks using mm-wave frequencies, require high gain antennas to overcome adverse channel conditions. These networks could be greatly aided by adaptive beamforming antenna arrays, which can significantly simplify the installation and maintenance costs (e.g., by enabling automatic beam alignment). However, building large, low cost beamforming arrays is very complicated. In this paper, we examine the main challenges presented by large arrays, starting from electromagnetic and antenna design and proceeding to the signal processing and algorithms domain. We propose 3-dimensional antenna structures and hybrid RF/digital radio architectures that can significantly reduce the complexity and improve the power efficiency of adaptive array systems. We also present signal processing techniques based on adaptive filtering methods that enhance the robustness of these architectures. Finally, we present computationally efficient vector quantization techniques that significantly improve the interference cancellation capabilities of analog beamforming architectures. © 2010 IEEE.

  19. Transportation-cyber-physical-systems-oriented engine cylinder pressure estimation using high gain observer

    Science.gov (United States)

    Li, Yong-Fu; Xiao-Pei, Kou; Zheng, Tai-Xiong; Li, Yin-Guo

    2015-05-01

    In transportation cyber-physical-systems (T-CPS), vehicle-to-vehicle (V2V) communications play an important role in the coordination between individual vehicles as well as between vehicles and the roadside infrastructures, and engine cylinder pressure is significant for engine diagnosis on-line and torque control within the information exchange process under V2V communications. However, the parametric uncertainties caused from measurement noise in T-CPS lead to the dynamic performance deterioration of the engine cylinder pressure estimation. Considering the high accuracy requirement under V2V communications, a high gain observer based on the engine dynamic model is designed to improve the accuracy of pressure estimation. Then, the analyses about convergence, converge speed and stability of the corresponding error model are conducted using the Laplace and Lyapunov method. Finally, results from combination of Simulink with GT-Power based numerical experiments and comparisons demonstrate the effectiveness of the proposed approach with respect to robustness and accuracy. Project supported by the National Natural Science Foundation of China (Grant No. 61304197), the Scientific and Technological Talents of Chongqing, China (Grant No. cstc2014kjrc-qnrc30002), the Key Project of Application and Development of Chongqing, China (Grant No. cstc2014yykfB40001), the Natural Science Funds of Chongqing, China (Grant No. cstc2014jcyjA60003), and the Doctoral Start-up Funds of Chongqing University of Posts and Telecommunications, China (Grant No. A2012-26).

  20. Expanded insecticide catabolic activity gained by a single nucleotide substitution in a bacterial carbamate hydrolase gene.

    Science.gov (United States)

    Öztürk, Başak; Ghequire, Maarten; Nguyen, Thi Phi Oanh; De Mot, René; Wattiez, Ruddy; Springael, Dirk

    2016-12-01

    Carbofuran-mineralizing strain Novosphingobium sp. KN65.2 produces the CfdJ enzyme that converts the N-methylcarbamate insecticide to carbofuran phenol. Purified CfdJ shows a remarkably low KM towards carbofuran. Together with the carbaryl hydrolase CehA of Rhizobium sp. strain AC100, CfdJ represents a new protein family with several uncharacterized bacterial members outside the proteobacteria. Although both enzymes differ by only four amino acids, CehA does not recognize carbofuran as a substrate whereas CfdJ also hydrolyzes carbaryl. None of the CfdJ amino acids that differ from CehA were shown to be silent regarding carbofuran hydrolytic activity but one particular amino acid substitution, i.e., L152 to F152, proved crucial. CfdJ is more efficient in degrading methylcarbamate pesticides with an aromatic side chain whereas CehA is more efficient in degrading the oxime carbamate nematicide oxamyl. The presence of common flanking sequences suggest that the cfdJ gene is located on a remnant of the mobile genetic element Tnceh carrying cehA. Our results suggest that these enzymes can be acquired through horizontal gene transfer and can evolve to degrade new carbamate substrates by limited amino acid substitutions. We demonstrate that a carbaryl hydrolase can gain the additional capacity to degrade carbofuran by a single nucleotide transversion. © 2016 Society for Applied Microbiology and John Wiley & Sons Ltd.

  1. Studies of relative gain and timing response of fine-mesh photomultiplier tubes in high magnetic fields

    Energy Technology Data Exchange (ETDEWEB)

    Sulkosky, Vincent A. [Univ. of Virginia, Charlottesville, VA (United States); Allison-Russell, Lyndsey L. [Hampton Univ., Hampton, VA (United States); Barber, Corinne C. [Univ. of South Carolina, Columbia, SC (United States); Cao, Tongtong [Univ. of South Carolina, Columbia, SC (United States); Ilieva, Yordanka [Univ. of South Carolina, Columbia, SC (United States); Jin, Kai [Univ. of Virginia, Charlottesville, VA (United States); Kalicy, Grzegorz [Old Dominion Univ., Norfolk, VA (United States); Park, K. [Old Dominion Univ., Norfolk, VA (United States); Ton, N. [Univ. of Virginia, Charlottesville, VA (United States); Zheng, Xiaochao [Univ. of Virginia, Charlottesville, VA (United States)

    2016-05-01

    We investigated the use of Hamamatsu fine-mesh photomultiplier tube assemblies H6152-70 and H6614-70 with regards to their gain and timing resolution in magnetic fields up to 1.9 T. Our results show that the H6614-70 assembly can operate reliably in magnetic fields exceeding 1.5 T, while preserving a reasonable timing resolution even with a gain reduction of a factor of ~100. The reduction of the relative gain of the H6152-70 is similar to the H6614-70's near 1.5 T, but its timing resolution worsens considerably at this high field.

  2. High indium content graded channel GainAs/AlinAs pseudomorphic MODFETs

    Science.gov (United States)

    Laskar, J.; Kolodzey, J.; Boor, S.; Hsieh, K. C.; Kalem, S.; Caracci, S.; Ketterson, A. A.; Brock, T.; Adesida, I.; Sivco, D.; Cho, A. Y.

    1990-03-01

    We report on the electrical and microstructural properties of InP/GaxIn 1 -xAs/Al0.48In0.52As modulation doped layers having compositionally graded active channels with different channel thicknesses. The layers were grown by solid source molecular beam epitaxy on Fe-doped InP substrates. The undoped GaInAs two dimensional electron gas channel layers were grown having indium compositions graded from x = 0.53 at the substrate buffer to x= 0.65 at the heterointerface by varying the Ga cell temperature during growth. Active channel thicknesses of 20 nm and 30 nm were compared with lattice matched layers. Transmission electron microscope image analysis indicates no misfit dislocations in these structures. Hall-effect measurements at 300 K show an increase in the mobility from 8,380 cm2/Vs for the lattice matched layer to 12,500 cm2/Vs for the 30 nm pseudomorphic layer. Small gate-length, 0.25 μn, MODFETs were fabricated to determine effective velocity values from transconductance ( g m ) and current gain ( h 21 ) measurements. The peak dc extrinsic g m increased from 367 mS/mm for the lattice matched layer to 668 mS/mm for the 30 nm pseudomorphic layer. The effective electron carrier velocity increased from 1.57 × 107 cm/s for the lattice matched layer to 1.88 × 107 cm/s for the 30 nm pseudomorphic layer. Our results show that compositional grading is a useful technique to obtain thick pseudomorphic layers with good transport properties.

  3. Reduced sympathetic nervous activity. A potential mechanism predisposing to body weight gain.

    Science.gov (United States)

    Spraul, M; Ravussin, E; Fontvieille, A M; Rising, R; Larson, D E; Anderson, E A

    1993-01-01

    The sympathetic nervous system is recognized to play a role in the etiology of animal and possibly human obesity through its impact on energy expenditure and/or food intake. We, therefore, measured fasting muscle sympathetic nerve activity (MSNA) in the peroneal nerve and its relationship with energy expenditure and body composition in 25 relatively lean Pima Indian males (means +/- SD; 26 +/- 6 yr, 82 +/- 19 kg, 28 +/- 10% body fat) and 19 Caucasian males (29 +/- 5 yr, 81 +/- 13 kg, 24 +/- 9% body fat). 24-h energy expenditure, sleeping metabolic rate, and resting metabolic rate were measured in a respiratory chamber, whereas body composition was estimated by hydrodensitometry. Pima Indians had lower MSNA than Caucasians (23 +/- 6 vs 33 +/- 10 bursts/min, P = 0.0007). MSNA was significantly related to percent body fat in Caucasians (r = 0.55, P = 0.01) but not in Pimas. MSNA also correlated with energy expenditure adjusted for fat-free mass, fat mass, and age in Caucasians (r = 0.51, P = 0.03; r = 0.54, P = 0.02; and r = 0.53, P = 0.02 for adjusted 24-h energy expenditure, sleeping metabolic rate, and resting metabolic rate, respectively) but not in Pima Indians. In conclusion, the activity of the sympathetic nervous system is a determinant of energy expenditure in Caucasians. Individuals with low resting MSNA may be at risk for body weight gain resulting from a lower metabolic rate. A low resting MSNA and the lack of impact of MSNA on metabolic rate might play a role in the etiology of obesity in Pima Indians. PMID:8408625

  4. Sensitivity- and effort-gain analysis: multilead ECG electrode array selection for activation time imaging.

    Science.gov (United States)

    Hintermüller, Christoph; Seger, Michael; Pfeifer, Bernhard; Fischer, Gerald; Modre, Robert; Tilg, Bernhard

    2006-10-01

    Methods for noninvasive imaging of electric function of the heart might become clinical standard procedure the next years. Thus, the overall procedure has to meet clinical requirements as an easy and fast application. In this paper, we propose a new electrode array which improves the resolution of methods for activation time imaging considering clinical constraints such as easy to apply and compatibility with routine leads. For identifying the body-surface regions where the body surface potential (BSP) is most sensitive to changes in transmembrane potential (TMP), a virtual array method was used to compute local linear dependency (LLD) maps. The virtual array method computes a measure for the LLD in every point on the body surface. The most suitable number and position of the electrodes within the sensitive body surface regions was selected by constructing effort gain (EG) plots. Such a plot depicts the relative attainable rank of the leadfield matrix in relation to the increase in number of electrodes required to build the electrode array. The attainable rank itself was computed by a detector criterion. Such a criterion estimates the maximum number of source space eigenvectors not covered by noise when being mapped to the electrode space by the leadfield matrix and recorded by a detector. From the sensitivity maps, we found that the BSP is most sensitive to changes in TMP on the upper left frontal and dorsal body surface. These sensitive regions are covered best by an electrode array consisting of two L-shaped parts of approximately 30 cm x 30 cm and approximately 20 cm x 20 cm. The EG analysis revealed that the array meeting clinical requirements best and improving the resolution of activation time imaging consists of 125 electrodes with a regular horizontal and vertical spacing of 2-3 cm.

  5. High-intensity resistance training amplifies muscle hypertrophy and functional gains in persons with Parkinson's disease.

    Science.gov (United States)

    Dibble, Leland E; Hale, Tessa F; Marcus, Robin L; Droge, John; Gerber, J Parry; LaStayo, Paul C

    2006-09-01

    Strength deficits in persons with Parkinson's disease (PD) have been identified as a contributor to bradykinesia. However, there is little research that examines the effect of resistance training on muscle size, muscle force production, and mobility in persons with PD. The purpose of this exploratory study was to examine, in persons with PD, the changes in quadriceps muscle volume, muscle force production, and mobility as a result of a 12-week high-force eccentric resistance training program and to compare the effects to a standard-care control. Nineteen individuals with idiopathic PD were recruited and consented to participate. Matched assignment for age and disease severity resulted in 10 participants in the eccentric group and 9 participants in the control group. All participants were tested prior to and following a 12-week intervention period with testing and training conducted at standardized times in their medication cycle. The eccentric group performed high-force quadriceps contractions on an eccentric ergometer 3 days a week for 12 weeks. The standard-care group exercise program encompassed standard exercise management of PD. The outcome variables were quadriceps muscle volume, muscle force, and mobility measures (6-minute walk, stair ascent/descent time). Each outcome variable was tested using separate one-way analyses of covariance on the difference scores. Muscle volume, muscle force, and functional status improvements occurred in persons with PD as a result of high-force eccentric resistance training. The eccentric group demonstrated significantly greater difference scores for muscle structure, stair descent, and 6-minute walk (P eccentric group consistently exceeded those in the standard-care group for all variables. To our knowledge, this is the first clinical trial to investigate and demonstrate the effects of eccentric resistance training on muscle hypertrophy, strength, and mobility in persons with PD. Additional research is needed to determine the

  6. Electrical vagus nerve stimulation decreases food consumption and weight gain in rats fed a high-fat diet.

    Science.gov (United States)

    Gil, Krzysztof; Bugajski, A; Thor, P

    2011-12-01

    There is growing evidence that vagus nerve stimulation (VNS) has a suppressive effect on both short- and long-term feeding in animal models. We previously showed that long-term VNS (102 days) with low-frequency electrical impulses (0.05 Hz) decreased food intake and body weight in rats. In the present study, we investigated the effect of high frequency (10 Hz) VNS on feeding behavior and appetite in rats fed a high-fat diet; peptide secretion and other parameters were assessed as well. Adult male Wistar rats were each implanted subcutaneously with a microstimulator (MS) and fed a high-fat diet throughout the entire study period (42 days). The left vagus nerve was stimulated by rectangular electrical pulses (10 ms, 200 mV, 10 Hz, 12 h a day) generated by the MS. Body weight and food intake were measured each morning. At the end of the experimental period, animals were euthanized and blood samples were taken. Serum levels of ghrelin, leptin and nesfatin-1 were assessed using radioimmunoassays. Adipose tissue content was evaluated by weighing epididymal fat pads, which were incised at the time of sacrifice. To determine whether VNS activated the food-related areas of the brain, neuronal c-Fos induction in the nuclei of the solitary tract (NTS) was assessed. Chronic vagus nerve stimulation significantly decreased food intake, body weight gain and epididymal fat pad weight in animals that received VNS compared with control animals. Significant neuronal responses in the NTS were observed following VNS. Finally, serum concentrations of ghrelin were increased, while serum levels of leptin were decreased. Although not significant, serum nesfatin-1 levels were also elevated. These results support the theory that VNS leads to reductions in food intake, body weight gain and adipose tissue by increasing brain satiety signals conducted through the vagal afferents. VNS also evoked a feed-related hormonal response, including elevated blood concentrations of nesfatin-1.

  7. Spacecraft Angular Rates Estimation with Gyrowheel Based on Extended High Gain Observer

    Directory of Open Access Journals (Sweden)

    Xiaokun Liu

    2016-04-01

    Full Text Available A gyrowheel (GW is a kind of electronic electric-mechanical servo system, which can be applied to a spacecraft attitude control system (ACS as both an actuator and a sensor simultaneously. In order to solve the problem of two-dimensional spacecraft angular rate sensing as a GW outputting three-dimensional control torque, this paper proposed a method of an extended high gain observer (EHGO with the derived GW mathematical model to implement the spacecraft angular rate estimation when the GW rotor is working at large angles. For this purpose, the GW dynamic equation is firstly derived with the second kind Lagrange method, and the relationship between the measurable and unmeasurable variables is built. Then, the EHGO is designed to estimate and calculate spacecraft angular rates with the GW, and the stability of the designed EHGO is proven by the Lyapunov function. Moreover, considering the engineering application, the effect of measurement noise in the tilt angle sensors on the estimation accuracy of the EHGO is analyzed. Finally, the numerical simulation is performed to illustrate the validity of the method proposed in this paper.

  8. Spacecraft Angular Rates Estimation with Gyrowheel Based on Extended High Gain Observer.

    Science.gov (United States)

    Liu, Xiaokun; Yao, Yu; Ma, Kemao; Zhao, Hui; He, Fenghua

    2016-04-14

    A gyrowheel (GW) is a kind of electronic electric-mechanical servo system, which can be applied to a spacecraft attitude control system (ACS) as both an actuator and a sensor simultaneously. In order to solve the problem of two-dimensional spacecraft angular rate sensing as a GW outputting three-dimensional control torque, this paper proposed a method of an extended high gain observer (EHGO) with the derived GW mathematical model to implement the spacecraft angular rate estimation when the GW rotor is working at large angles. For this purpose, the GW dynamic equation is firstly derived with the second kind Lagrange method, and the relationship between the measurable and unmeasurable variables is built. Then, the EHGO is designed to estimate and calculate spacecraft angular rates with the GW, and the stability of the designed EHGO is proven by the Lyapunov function. Moreover, considering the engineering application, the effect of measurement noise in the tilt angle sensors on the estimation accuracy of the EHGO is analyzed. Finally, the numerical simulation is performed to illustrate the validity of the method proposed in this paper.

  9. Microlens array-based high-gain screen design for direct projection head-up displays.

    Science.gov (United States)

    Hedili, M Kivanc; Freeman, Mark O; Urey, Hakan

    2013-02-20

    Head-up display (HUD) systems have been used in recent car models to provide essential information to the drivers while keeping their eyes on the road. Virtual image HUD systems have been the preferred method, but they have the drawback of requiring a large volume of space in order to accommodate the relay optics that creates the virtual image. This is especially significant as the desired field of view increases. Direct projection HUD systems have been developed with a separate stand-alone microlens array (MLA)-based transparent screen on the dashboard, offering a compact solution. In this paper, we propose a direct projection HUD system based on a unique, windshield-embedded see-through screen that uses minimal space under the dashboard, offering an elegant and compact solution to the HUD problem. The screen is based on MLAs with varying surface normal angles such that the light from the projector is directed to the viewer's eyes from all positions across the field of view. Varying tilts provide an efficient relay and high brightness even with a low-lumen output projector. The calculated screen gain is about 69 and the eyebox area is about 30 cm×30 cm.

  10. High speed gain coupled DFB laser diode integrated with MQW electroabsorption modulator

    CERN Document Server

    Kim, M G; Park, S S; Oh, D K; Lee, H T; Kim, H M; Pyun, K E

    1998-01-01

    We have demonstrated stable modulation characteristics of the gain coupled distributed feedback(GC-DFB) laser diode integrated with butt-coupled InGaAsP/InGaAsP strain compensated MQW(multiple-Quantum-well) modulator for high speed optical transmission. For this purpose, we have adopted the InGaAsP/InGaAsP strain compensated MQW structure for the EA modulator and n-doped InGaAs absorptive grating for DFB laser. The typical threshold current and slope efficiency were about 15 mA and 0.1 mW/mA, respectively. The extinction ratio of fabricated integrated device was about 15 dB at -2 V, and the small signal bandwidth was shown to be around 17GHz. We also found that the alpha parameter becomes negative at below a -0.6 V bias voltage. We transmitted 10 Gbps NRZ electrical signal over 90 km of standard single mode optical fiber (SMF). A clearly opened eye diagram was observed in the modulated output.

  11. BiCMOS operational amplifier with precise and stable dc gain for high-frequency switched capacitor circuits

    Science.gov (United States)

    Baschirotto, A.; Alini, R.; Castello, R.

    1991-07-01

    A novel approach in the design of high-frequency switched capacitor (SC) circuits is presented. It is based on the use of simple and fast amplifiers with low but precisely controlled gain value. The effect of the precisely known and stable opamp gain is compensated for by changing the capacitor values during the synthesis of the SC cell. An example of an opamp with these features and the synthesis of a biquadratic filter based on this approach are given.

  12. Fructans from Agave tequilana with a Lower Degree of Polymerization Prevent Weight Gain, Hyperglycemia and Liver Steatosis in High-Fat Diet-Induced Obese Mice

    OpenAIRE

    Márquez-Aguirre, A. L.; Camacho-Ruíz, R. M.; Gutiérrez-Mercado, Y. K.; Padilla-Camberos, E.; González-Ávila, M.; Gálvez-Gastélum, F. J.; N.E. Díaz-Martínez; Ortuño-Sahagún, D.

    2016-01-01

    Fructans from agave have received specific attention because of their highly branched fructan content. We have previously reported that the degree of polymerization (dp) influences their biological activity. Therefore, the aim of this study was to investigate the effect of unfractionated and fractionated fructans (higher and lower dps) from Agave tequilana in high-fat diet-induced (HFD) obese mice. Fructans with a lower dp (HFD+ScF) decreased weight gain by 30 %, body fat mass by 51 %, hyperg...

  13. SOFT X-RAY FEL BY CASCADING STAGES OF HIGH GAIN HARMONIC GENERATION.

    Energy Technology Data Exchange (ETDEWEB)

    YU,L.H.

    2003-04-17

    Short wavelength Free-Electron Lasers are perceived as the next generation of synchrotron light sources. In the past decade, significant advances have been made in the theory and technology of high brightness electron beams and single pass FELs. These developments facilitate the construction of practical VUV FELs and make x-ray FELs possible. Self-Amplified Spontaneous Emission (SASE) and High Gain Harmonic Generation (HGHG)[17-19] are the two leading candidates for x-ray FELs. The first lasing of HGHG proof-of-principle experiment succeeded in August, 1999 in Brookhaven National Laboratory. The experimental results agree with the theory prediction. Compared with SASE FEL, the following advantages of HGHG FEL were confirmed; (1) Better longitudinal coherence, and hence, much narrower bandwidth than SASE. (2) More stable central wavelength, (3) More stable output energy. In this introduction, we will first briefly describe the principle of HGHG in Section A. Then in Section B, we give a general description about how to produce soft x-ray by cascading HGHG scheme. In section 2, we give a detailed description of the system design. Then, in section 3, we give a description of an analytical estimate for the HGHG process, and the calculation of the parameters of different parts of the system. The estimate is found to agree with simulation within about a factor 2 for most cases we studied. The stability issue, the sensitivity to parameter variation, the harmonic contents of the final output, and the noise degradation issue of such HGHG scheme are discussed in Section 4. The results are presented in Section 4. Finally, in Section 5, we will give some discussion of the challenges in development of the system. The conclusion is given in Section 6.

  14. Dynamic Sliding Mode Evolution PWM Controller for a Novel High-Gain Interleaved DC-DC Converter in PV System

    Directory of Open Access Journals (Sweden)

    Taizhou Bei

    2014-01-01

    Full Text Available Considering the disadvantages of the traditional high-gain DC-DC converter such as big size, high voltage stress of switches, and large input current ripple, a novel high-gain interleaved boost converter with coupled-inductor and switched-capacitor was proposed correspondingly and the operation principle together with the steady-state analysis of this converter was also described. Besides, a new control approach-dynamic sliding mode evolution PWM controller (DSME PWM for the novel topological converter based on both dynamic evolution and sliding mode control was also presented. From the simulation results and experimental validation the proposed converter can fulfill high-gain boost, low ripple of both the input current and the output voltage. Furthermore, MPPT technique can be also achieved in a short time by simulation. The efficiency and stability of the converter proposed in this paper can be improved.

  15. Design and performance of an Automatic Gain Control system for the High Energy X-Ray Timing Experiment

    Science.gov (United States)

    Pelling, Michael R.; Rothschild, Richard E.; Macdonald, Daniel R.; Hertel, Robert; Nishiie, Edward

    1991-01-01

    The High Energy X-Ray Timing Experiment (HEXTE), currently under development for the X-Ray Timing Explorer (XTE) mission, employs a closed loop gain control system to attain 0.5 percent stabilization of each of eight-phoswich detector gains. This Automatic Gain Control (AGC) system utilizes a split window discriminator scheme to control the response of each detector pulse height analyzer to gated Am-241 X-ray events at 60 keV. A prototype AGC system has been implemented and tested within the gain perturbation environment expected to be experienced by the HEXTE instrument in flight. The AGC system and test configuration are described. Response, stability and noise characteristics are measured and compared with theoretical predictions. The system is found to be generally suitable for the HEXTE application.

  16. Design and performance of an Automatic Gain Control system for the High Energy X-Ray Timing Experiment

    Science.gov (United States)

    Pelling, Michael R.; Rothschild, Richard E.; Macdonald, Daniel R.; Hertel, Robert; Nishiie, Edward

    1991-01-01

    The High Energy X-Ray Timing Experiment (HEXTE), currently under development for the X-Ray Timing Explorer (XTE) mission, employs a closed loop gain control system to attain 0.5 percent stabilization of each of eight-phoswich detector gains. This Automatic Gain Control (AGC) system utilizes a split window discriminator scheme to control the response of each detector pulse height analyzer to gated Am-241 X-ray events at 60 keV. A prototype AGC system has been implemented and tested within the gain perturbation environment expected to be experienced by the HEXTE instrument in flight. The AGC system and test configuration are described. Response, stability and noise characteristics are measured and compared with theoretical predictions. The system is found to be generally suitable for the HEXTE application.

  17. The Design of High-Q Sallen-Key Biquads with Unity-Gain Buffer Amplifiers

    DEFF Research Database (Denmark)

    Gaunholt, Hans; Guldbrandsen, Birthe

    1997-01-01

    analog filters in voltage-mode as well as current-mode technology. As an example we will choose the band-pass biquad as biquads of this type often has to be designed with high-Q values. The results in the band-pass case may readily be transferred to the low-pass and high-pass cases.......In the design of active biquads with negative feedback frequently referred to as Sallen-Key networks the assumption of a low quality- or Q-factor is recommended in order to keep the active sensitivities at a reasonable low value. In this paper it will be shown that it is possible to design...

  18. The impact of stopping high-energy oral nutritional supplements on eating behaviour and weight gain.

    Science.gov (United States)

    Wright, Charlotte M; Chillingworth, Anna

    2015-11-01

    Many children referred to a tertiary feeding clinic are already taking high-energy oral nutritional supplements (HEOS), but these often seem not clinically useful. We undertook a retrospective review of all children on HEOS at the time of referral to the clinic in order to describe their subsequent progress in terms of growth and feeding behaviour. A total of 48 children were on HEOS at referral and withdrawal of HEOS was attempted in 38 children, aged median 3.0 years (range 0.7-10 years) who were taking volumes equivalent to 2/3 of total daily energy requirements. The children tended to be very short and slim (median height SD score (SDS) -2.0 (range -5.7 to 1.9); body mass index -2.0 (-5.1 to 1.9)). Half had normal neurodevelopment (ND) but 4 (11%) had learning disability and 4 (11%) severe ND problems. By last follow-up after 0.86 (0-2.9) years, 30 (79%) had stopped all feeds. Those who stopped had a mean (SD) change in weight of 0.08 (0.6) SDS (range -0.88 to +1.59). Five children (17%) showed significant catch-up weight gain after stopping feeds, of whom three had been referred for weight faltering and possible tube feeding. Improvement in feeding behaviour was documented in 76% (29). The use of HEOS in children suppresses appetite for solid food due to energy compensation. In some cases, HEOS may perpetuate or even cause weight faltering. It should not be assumed that failure to respond to HEOS is an indication for tube feeding. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  19. A high conversion-gain Q-band InP DHBT subharmonic mixer using LO frequency doubler

    DEFF Research Database (Denmark)

    Johansen, Tom Keinicke; Vidkjær, Jens; Krozer, Viktor;

    2008-01-01

    The paper presents analysis and design of a Q-band subharmonic mixer (SHM) with high conversion gain. The SHM consists of a local oscillator (LO) frequency doubler, RF pre-amplifier, and single-ended mixer. The SHM has been fabricated in a high-speed InP double heterojunction bipolar transistor...

  20. Effects of Dietary Carbohydrate Sources on Daily Weight Gain and Digestive Enzyme Activities of Juvenile Peanut Worm(Sipunculus nudus)

    Institute of Scientific and Technical Information of China (English)

    Zhang Qin; Xu Mingzhu; Tong Tong; Dong Lanfang

    2015-01-01

    In the study,glucose,sucrose,dextrin,tapioca starch,potato starch,corn starch and gelatinized corn starch were selected to make the diets with same nitrogen and lipid,and Juvenile peanut worms( Sipunculus nudus) were fed with the diets came from different carbohydrate sources,effects of diets with different carbohydrate sources on daily weight gain and digestive enzyme activities of S. nudus were studied. Results showed that diets with different carbohydrate sources had significant influences on daily weight gain and digestive enzyme activities of S. nudus( P < 0. 05). Daily weight gain in gelatinized corn starch group was significantly higher than that in other groups( P < 0. 05); daily weight gain in glucose group was significantly lower than that in other groups( P < 0. 05); daily weight gain in the three ungelatinized starch groups was significantly higher than that in glucose,sucrose and dextrin groups( P < 0. 05). Analysis of digestive enzyme activities showed that dietary carbohydrate sources had significant influences on digestive enzyme activities of S. nudus( P < 0. 05). Protease activities and amylase activities of S. nudus in sucrose group were the highest,which were significantly higher than that in the other groups( P < 0. 05); lipase activities of S. nudus in glucose group were the lowest,which were significantly lower than that in other groups( P < 0. 05). In conclusion,growth-promoting effects of macromolecules carbohydrates( starch) were better than that of disaccharide( sucrose) and monosaccharide( glucose),which of gelatinized starch were better than that of ungelatinized starch.

  1. A PMT-like high gain avalanche photodiode based on GaN/AlN periodical stacked structure

    CERN Document Server

    Zheng, Ji-yuan; Yang, Di; Yu, Jia-dong; Meng, Xiao; E, Yan-xiong; Wu, Chao; Hao, Zhi-biao; Sun, Chang-zheng; Xiong, Bing; Luo, Yi; Han, Yan-jian; Wang, Jian; Li, Hong-tao; Brault, Julien; Matta, Samuel; Khalfioui, Mohamed Al; Yan, Jian-chang; Wei, Tong-bo; Zhang, Yun; Wang, Jun-xi

    2016-01-01

    Avalanche photodiode (APD) has been intensively investigated as a promising candidate to replace photomultiplier tubes (PMT) for weak light detection. However, in conventional APDs, a large portion of carrier energy drawn from the electric field is thermalized, and the multiplication efficiencies of electron and hole are low and close. In order to achieve high gain, the device should work under breakdown bias, where carrier multiplication proceeds bi-directionally to form a positive feedback multiplication circle. However, breakdown is hard to control, in practice, APDs should work under Geiger mode as a compromise between sustainable detection and high gain. The complexity of system seriously restricts the application. Here, we demonstrate an avalanche photodiode holding high gain without breakdown, which means no quenching circuit is needed for sustainable detection. The device is based on a GaN/AlN periodically-stacked-structure (PSS), wherein electron holds much higher efficiency than hole to draw energy ...

  2. Double-pass ytterbium-doped fiber amplifier with high gain coefficient and low noise figure

    Institute of Scientific and Technical Information of China (English)

    Anting Wang(王安廷); Meishu Xing(邢美术); Guanghui Chen(陈光辉); Wenkui Yang(杨文奎); Hai Ming(明海); Jianping Xie(谢建平); Yunxia Wu(吴云霞)

    2003-01-01

    We have proposed and demonstrated a double-pass ytterbium-doped fiber amplifier using an optical circulator and a fiber Bragg grating as reflector. When the signal has passed through the ytterbium-doped fiber once, it reflects off a 0.2-nm passive fiber Bragg grating filter. This reduces amplified spontaneous emission (ASE) noise from the first pass. The input signal light is amplified both forward and backward through ytterbium-doped fiber. With this double-pass configuration, 1053.15-nm unsaturated signal gain of 28 dB, gain coefficient of 1.1 dB/mW, and noise figure of less than 4 dB are achieved at 977-nm pump power of 68 mW. It is also found that this double-pass configure provides enhancing gain coefficient and improving noise figure by comparison with single-pass configuration.

  3. Gaining A Geological Perspective Through Active Learning in the Large Lecture Classroom

    Science.gov (United States)

    Kapp, J. L.; Richardson, R. M.; Slater, S. J.

    2008-12-01

    NATS 101 A Geological Perspective is a general education course taken by non science majors. We offer 600 seats per semester, with four large lecture sections taught by different faculty members. In the past we have offered optional once a week study groups taught by graduate teaching assistants. Students often feel overwhelmed by the science and associated jargon, and many are prone to skipping lectures altogether. Optional study groups are only attended by ~50% of the students. Faculty members find the class to be a lot of work, mainly due to the grading it generates. Activities given in lecture are often short multiple choice or true false assignments, limiting the depth of understanding we can evaluate. Our students often lack math and critical thinking skills, and we spend a lot of time in lecture reintroducing ideas students should have already gotten from the text. In summer 2007 we were funded to redesign the course. Our goals were to 1) cut the cost of running the course, and 2) improve student learning. Under our redesign optional study groups were replaced by once a week mandatory break out sessions where students complete activities that have been introduced in lecture. Break out sessions substitute for one hour of lecture, and are run by undergraduate preceptors and graduate teaching assistants (GTAs). During the lecture period, lectures themselves are brief with a large portion of the class devoted to active learning in small groups. Weekly reading quizzes are submitted via the online course management system. Break out sessions allow students to spend more time interacting with their fellow students, undergraduate preceptors, and GTAs. They get one on one help in break out sessions on assignments designed to enhance the lecture material. The active lecture format means less of their time is devoted to listening passively to a lecture, and more time is spent peer learning an interacting with the instructor. Completing quizzes online allows students

  4. High energy gain in three-dimensional simulations of light sail acceleration

    Energy Technology Data Exchange (ETDEWEB)

    Sgattoni, A., E-mail: andrea.sgattoni@polimi.it [Dipartimento di Energia, Politecnico di Milano, Milano (Italy); CNR, Istituto Nazionale di Ottica, u.o.s. “Adriano Gozzini,” Pisa (Italy); Sinigardi, S. [CNR, Istituto Nazionale di Ottica, u.o.s. “Adriano Gozzini,” Pisa (Italy); Dipartimento di Fisica e Astronomia, Università di Bologna, Bologna (Italy); INFN sezione di Bologna, Bologna (Italy); Macchi, A. [CNR, Istituto Nazionale di Ottica, u.o.s. “Adriano Gozzini,” Pisa (Italy); Dipartimento di Fisica “Enrico Fermi,” Università di Pisa, Pisa (Italy)

    2014-08-25

    The dynamics of radiation pressure acceleration in the relativistic light sail regime are analysed by means of large scale, three-dimensional (3D) particle-in-cell simulations. Differently to other mechanisms, the 3D dynamics leads to faster and higher energy gain than in 1D or 2D geometry. This effect is caused by the local decrease of the target density due to transverse expansion leading to a “lighter sail.” However, the rarefaction of the target leads to an earlier transition to transparency limiting the energy gain. A transverse instability leads to a structured and inhomogeneous ion distribution.

  5. Highly anisotropic mobility in solution processed TIPS-pentacene film studied by independently driven four GaIn probes

    Science.gov (United States)

    Yoshimoto, Shinya; Takahashi, Kohtaro; Suzuki, Mitsuharu; Yamada, Hiroko; Miyahara, Ryosuke; Mukai, Kozo; Yoshinobu, Jun

    2017-08-01

    We have studied in-plane anisotropy in the field-effect mobility of solution-processed organic semiconductor 6,13-bis(triisopropylsilylethynyl)pentacene by using independently driven four gallium indium (Ga-In) probes. Liquid-metal Ga-In probes are highly effective for reproducible conductivity measurements of organic thin films. We demonstrated that a high mobility anisotropy of 44 was obtained by using a square four-probe method and a feedback circuit to keep the channel potential constant. The present method minimized the influences of the contact resistance and the insensitivity of anisotropy in a linear arrangement in two-dimensional field-effect transistors.

  6. Steps Ahead: Adaptation of physical activity and dietary guidelines for reducing unhealthy weight gain in the Lower Misissippi Delta

    Science.gov (United States)

    The purpose of our study was to test the effectiveness of adapting the Dietary Guidelines for Americans (2010) (DG), with and without a physical activity (PA) component, in reducing weight gain in the Lower Mississippi Delta region (LMD) of the United States. A sample of 121 White and African-Americ...

  7. The Effects of Activity and Gain Based Virtual Material on Student's Success, Permanency and Attitudes towards Science Lesson

    Science.gov (United States)

    Tas, Erol

    2015-01-01

    The main objective of this study is to research the effects of a student gains and activity based virtual material on students' success, permanence and attitudes towards science lesson, developed for science and technology lesson 6th grade "Systems in our body" unit. The study, which had a quasi-experimental design, was conducted with…

  8. Modelling Plant and Soil Nitrogen Feedbacks Affecting Forest Carbon Gain at High CO2

    Science.gov (United States)

    McMurtrie, R. E.; Norby, R. J.; Franklin, O.; Pepper, D. A.

    2007-12-01

    Short-term, direct effects of elevated atmospheric CO2 concentrations on plant carbon gain are relatively well understood. There is considerable uncertainty, however, about longer-term effects, which are influenced by various plant and ecosystem feedbacks. A key feedback in terrestrial ecosystems occurs through changes in plant carbon (C) allocation patterns. For instance, if high CO2 were to increase C allocation to roots, then plants may experience positive feedback through improved plant nutrition. A second type of feedback, associated with decomposition of soil-organic matter, may reduce soil-nutrient availability at high CO2. This paper will consider mechanistic models of both feedbacks. Effects of high CO2 on plant C allocation will be investigated using a simple model of forest net primary production (NPP) that incorporates the primary mechanisms of plant carbon and nitrogen (N) balance. The model called MATE (Model Any Terrestrial Ecosystem) includes an equation for annual C balance that depends on light- saturated photosynthetic rate and therefore on [CO2], and an equation for N balance incorporating an expression for N uptake as a function of root mass. The C-N model is applied to a Free Air CO2 Exchange (FACE) experiment at Oak Ridge National Laboratory (ORNL) in Tennessee, USA, where closed-canopy, monoculture stands of the deciduous hardwood sweetgum ( Liquidambar styraciflua) have been growing at [CO2] of 375 and 550 ppm for ten years. Features of this experiment are that the annual NPP response to elevated CO2 has averaged approximately 25% over seven years, but that annual fine-root production has almost doubled on average, with especially large increases in later years of the experiment (Norby et al. 2006). The model provides a simple graphical approach for analysing effects of elevated CO2 and N supply on leaf/root/wood C allocation and productivity. It simulates increases in NPP and fine-root production at the ORNL FACE site that are consistent

  9. The Linguistic Gains and Acculturation of American High School Students on Exchange Programs in Germany

    Science.gov (United States)

    Lovitt, Ashli

    2013-01-01

    There has been a sharp rise in study abroad participation over the last few decades (Institute for International Education, 2011), which can largely be explained by the rise of short-term study abroad programs. While there is much to be gained from participation in such programs, mid-length and year programs may offer the greatest benefits for…

  10. Differences in Personality Characteristics between Groups Having High and Low Mathematical Achievement Gain under Individualized Instruction.

    Science.gov (United States)

    Neufeld, K. Allen

    The problem of this study was to determine the relationship of selected characteristics of pupils to achievement gain in elementary school mathematics classes using the Individualized Mathematics Curriculum Project (IMCP) approach. Analysis o f data was based primarily on pre-achievement and post-achievement scores. The hypothesis that there was…

  11. The role of diet and physical activity in post-transplant weight gain after renal transplantation

    NARCIS (Netherlands)

    Zelle, Dorien M.; Kok, Trijntje; Dontje, Manon L.; Danchell, Eva I.; Navis, Gerjan; van Son, Willem J.; Bakker, Stephan J. L.; Corpeleijn, Eva

    2013-01-01

    Background Long-term survival of renal transplant recipients (RTR) has not improved over the past 20yr. The question rises to what extent lifestyle factors play a role in post-transplant weight gain and its associated risks after transplantation. Methods Twenty-six RTR were measured for body weight,

  12. No further gain can be achieved by calculating Disease Activity Score in 28 joints with high-sensitivity assay of C-reactive protein because of high intraindividual variability of C-reactive protein: A cross-sectional study and theoretical consideration.

    Science.gov (United States)

    Hansen, Inger M J; Emamifar, Amir; Andreasen, Rikke A; Antonsen, Steen

    2017-01-01

    Disease Activity Score in 28 joints (DAS28) is commonly used to evaluate disease activity of rheumatoid arthritis (RA) and is a guide to treatment decision.The aim of this study was to evaluate the impact of lower reporting limit for C-reactive protein (CRP), with respect to intraindividual biological variability, on the calculation of DAS28 and subsequent patient classification.This study consists of 2 sections: a theoretical consideration discussing the performance of CRP in calculating DAS28 taking intraindividual biological variation and lower reporting limit for CRP into account and a cross-sectional study of RA patients applying our theoretical results. Therefore, we calculated DAS28 twice, with the actual CRP values and CRP = 9 mg/L, the latter to elucidate the positive effects of reducing the lower reporting limit of CRP from <10 to <3 mg/L.Lower-reporting limit of <10 mg/L leads to overestimate DAS28. However, reducing lower reporting limit for CRP to <3 mg/L results in optimizing DAS28 calculation. Further lowering of reporting limit for CRP to <3 mg/L does not increase the precision of DAS28 owing to the relatively large intraindividual biological variation.Five hundred twelve patients were included. There was a significant difference between recalculated and patients DAS28 (P < 0.001). One hundred nine patients had DAS28 deviation (compatible to remission to low: 66, low to moderate: 39. and moderate to high: 4).Owing to significant impact of intraindividual biologic variation on DAS28 and patient classification, special attention should be paid to calculate DAS28 when CRP values are within normal range. Furthermore, we conclude that results of different studies evaluating DAS28 and treatment response are not comparable if the reporting limits of CRP are unknown.

  13. Large delay tunable slow-light based on high-gain stimulated-Brillouin-scattering amplification in optical fibers

    Institute of Scientific and Technical Information of China (English)

    XING Liang; ZHAN Li; XIA YuXing

    2009-01-01

    Tunable stimulated-Brillouin-scattering (SBS)-based slow-light in optical fibers has potential applications in optical buffering in the future all-optical router commutation systems.However,due to the low SBS threshold and relatively high realistic signal power,the gain in the usual SBS systems is limited at~30 dB.This paper presents a high-gain SBS scheme to realize large delay slow-light,which benefits from avoiding the depletion of the pump power in a short fiber as SBS media.The experiment demon strates that,up to 50 dB non-saturated gain has been observed in the single-stage 591.8 m fiber SBS amplification.The slow-light delay can be obtained 52 ns,and the fractional delay can exceed 1.

  14. Modified unscented Kalman filter using modified filter gain and variance scale factor for highly maneuvering target tracking

    Institute of Scientific and Technical Information of China (English)

    Changyun Liu; Penglang Shui; Gang Wei; Song Li

    2014-01-01

    To improve the low tracking precision caused by lagged filter gain or imprecise state noise when the target highly maneu-vers, a modified unscented Kalman filter algorithm based on the improved filter gain and adaptive scale factor of state noise is pre-sented. In every filter process, the estimated scale factor is used to update the state noise covariance Qk, and the improved filter gain is obtained in the filter process of unscented Kalman filter (UKF) via predicted variance Pk|k-1, which is similar to the standard Kalman filter. Simulation results show that the proposed algorithm provides better accuracy and ability to adapt to the highly maneu-vering target compared with the standard UKF.

  15. Green tea decoction improves glucose tolerance and reduces weight gain of rats fed normal and high-fat diet.

    Science.gov (United States)

    Snoussi, Chahira; Ducroc, Robert; Hamdaoui, Mohamed Hédi; Dhaouadi, Karima; Abaidi, Houda; Cluzeaud, Francoise; Nazaret, Corinne; Le Gall, Maude; Bado, André

    2014-05-01

    Green tea containing polyphenols exerts antidiabetic and antiobesity effects, but the mechanisms involved are not fully understood. In this study, we first analyzed and compared polyphenol compounds [epigallocatechin gallate (EGCG), epigallocatechin (EGC)] in decoction of green tea leaves versus usual green tea extracts. Second, the effects of acute (30 min) or chronic (6 weeks) oral administration of green tea decoction (GTD) on intestinal glucose absorption were studied in vitro in Ussing chamber, ex vivo using isolated jejunal loops and in vivo through glucose tolerance tests. Finally, we explore in rat model fed normal or high-fat diet the effects of GTD on body weight, blood parameters and on the relative expression of glucose transporters SGLT-1, GLUT2 and GLUT4. GTD cooked for 15 min contained the highest amounts of phenolic compounds. In fasted rats, acute administration of GTD inhibited SGLT-1 activity, increased GLUT2 activity and improved glucose tolerance. Similarly to GTD, acute administration of synthetic phenolic compounds (2/3 EGCG+1/3 EGC) inhibited SGLT-1 activity. Chronic administration of GTD in rat fed high-fat diet reduced body weight gain, circulating triglycerides and cholesterol and improved glucose tolerance. GTD-treated rats for 6 weeks display significantly reduced SGLT-1 and increased GLUT2 mRNA levels in the jejunum mucosa. Moreover, adipose tissue GLUT4 mRNA levels were increased. These results indicate that GTD, a traditional beverage rich in EGCG and EGC reduces intestinal SGLT-1/GLUT2 ratio, a hallmark of regulation of glucose absorption in enterocyte, and enhances adipose GLUT4 providing new insights in its possible role in the control of glucose homeostasis. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. Noticeable positive Doppler effect on optical bistability in an N-type active Raman gain atomic system

    Institute of Scientific and Technical Information of China (English)

    Chang Zeng-Guang; Niu Yue-Ping; Zhang Jing-Tao; Gong Shang-Qing

    2012-01-01

    We theoretically investigate the Doppler effect on optical bistability in an N type active Raman gain atomic system inside an optical ring cavity.It is shown that the Doppler effect can greatly enhance the dispersion and thus create the bistable behaviour or greatly increase the bistable region,which has been known as the positive Doppler effect on optical bistability.In addition,we find that a positive Doppler effect can change optical bistability from the hybrid dispersion-gain type to a dispersive type.

  17. Designing Gain- and Loss-Framed Messages to Increase Physical Activity among University Students Living in two Different Cultures

    OpenAIRE

    Pelin Ozgur Polat

    2015-01-01

    BACKGROUND Widespread evidence indicates that physical activity has positive effects on physical health in long-run. Therefore, adopting exercising habits at early ages is essential for reducing risk of developing chronic diseases. As a result, prevention studies frequently focus on informing young people about possible consequences of engaging or not engaging in physical activity to encourage them to develop a healthy lifestyle. Gain- and loss-framed health messages (Rothman & Salove...

  18. Sleep deprivation, physical activity and low income are risk factors for inadequate weight gain during pregnancy: a cohort study.

    Science.gov (United States)

    Abeysena, Chrishantha; Jayawardana, Pushpa

    2011-07-01

    To determine the possible risk factors for inadequate gestational weight gain. A population-based cohort study was carried out in Sri Lanka from May 2001 to April 2002. Pregnant women were recruited on or before 16 weeks' gestation and followed up until delivery; the sample size was 710. Trimester-specific exposure status and potential confounding factors were gathered on average at the 12th, 28th and 36th weeks of gestation. Maternal weight was measured at the first antenatal clinic visit and at delivery. Inadequate weight gain was defined as weight gain below the Institute of Medicine recommendations in 2009. Multiple logistic regression was applied and the results were expressed as odds ratios (OR) and 95% confidence intervals (95% CI). The risk factors for inadequate weight gain were low per-capita monthly income (OR 1.63, 95% CI 1.03, 2.58), multiparity (OR 1.96, 95% CI 1.34, 2.87), sleeping weight gain were low income, being multiparous, sleep deprivation, physical activity in terms of standing and walking, and the male sex of baby. © 2011 The Authors. Journal of Obstetrics and Gynaecology Research © 2011 Japan Society of Obstetrics and Gynecology.

  19. High gain micro-channel plate multipliers for particle tracking or single photo-electron counting

    Energy Technology Data Exchange (ETDEWEB)

    Oba, K.; Rehak, P.; Smith, S.D.

    1980-01-01

    Micro-channel plate multipliers have been used to detect the passage of relativistic charged particles. Measurements of the detection efficiency and pulse height response versus micro-channel plate gain are presented for one, two and three micro-channel plate arrays. Values describing temporal response and transit time jitter are also given. In a separate measurement, the response of a single micro-channel plate to individual slow electrons (less than or equal to 1 keV) was studied. By using a special technique output bunches as small as three electrons may be seen for low average micro-channel plate gain. The results of attempts to improve the micro-channel plate response are also presented.

  20. High-power gain-switched Tm(3+)-doped fiber laser.

    Science.gov (United States)

    Tang, Yulong; Xu, Lin; Yang, Yi; Xu, Jianqiu

    2010-10-25

    Gain-switched by a 1.914-µm Tm:YLF crystal laser, a two-stage Tm(3+) fiber laser has been achieved 100-W level ~2-µm pulsed laser output with a slope efficiency of ~52%. With the 6-m length of Tm fiber, the laser wavelength was centered at 2020 nm with a bandwidth of ~25 nm. Based on an acousto-optic switch, the pulse repetition rate can be modulated from 500 Hz to 50 kHz, and the laser pulse width can be tuned between 75 ns and ~1 µs. The maximum pulse energy was over 10 mJ, and the maximum pulse peak power was 138 kW. By using the fiber-coiling-induced mode-filtering effect, laser beam quality of M2 = 1.01 was obtained. Further scaling the pulse energy and average power from such kind of gain-switched fiber lasers was also discussed.

  1. A numerical algorithm for optimal feedback gains in high dimensional LQR problems

    Science.gov (United States)

    Banks, H. T.; Ito, K.

    1986-01-01

    A hybrid method for computing the feedback gains in linear quadratic regulator problems is proposed. The method, which combines the use of a Chandrasekhar type system with an iteration of the Newton-Kleinman form with variable acceleration parameter Smith schemes, is formulated so as to efficiently compute directly the feedback gains rather than solutions of an associated Riccati equation. The hybrid method is particularly appropriate when used with large dimensional systems such as those arising in approximating infinite dimensional (distributed parameter) control systems (e.g., those governed by delay-differential and partial differential equations). Computational advantage of the proposed algorithm over the standard eigenvector (Potter, Laub-Schur) based techniques are discussed and numerical evidence of the efficacy of our ideas presented.

  2. A numerical algorithm for optimal feedback gains in high dimensional linear quadratic regulator problems

    Science.gov (United States)

    Banks, H. T.; Ito, K.

    1991-01-01

    A hybrid method for computing the feedback gains in linear quadratic regulator problem is proposed. The method, which combines use of a Chandrasekhar type system with an iteration of the Newton-Kleinman form with variable acceleration parameter Smith schemes, is formulated to efficiently compute directly the feedback gains rather than solutions of an associated Riccati equation. The hybrid method is particularly appropriate when used with large dimensional systems such as those arising in approximating infinite-dimensional (distributed parameter) control systems (e.g., those governed by delay-differential and partial differential equations). Computational advantages of the proposed algorithm over the standard eigenvector (Potter, Laub-Schur) based techniques are discussed, and numerical evidence of the efficacy of these ideas is presented.

  3. Quantum spatial correlations in high-gain parametric down-conversion measured by means of a CCD camera

    DEFF Research Database (Denmark)

    Jedrkiewicz, O.; Brambilla, E.; Bache, Morten

    2006-01-01

    We consider travelling-wave parametric down-conversion in the high-gain regime and present the experimental demonstration of the quantum character of the spatial fluctuations in the system. In addition to showing the presence of sub-shot noise fluctuations in the intensity difference, we demonstr...

  4. Investigation of hole-blocking contacts for high-conversion-gain amorphous selenium detectors for X-ray imaging

    NARCIS (Netherlands)

    Abbaszadeh, S.; Allec, N.; Ghanbarzadeh, S.; Shafique, U.; Karim, K.S.

    2012-01-01

    In this paper, we investigated different organic and inorganic hole-blocking contacts for amorphous selenium (a-Se)-based photodetectors: CeO2, TiO2, perylene tetracarboxylic bisbenzimidazole (PTCBI), and polyimide (PI). CeO2 has previously been used as a blocking layer for high-gain a-Se devices. T

  5. Eigenmodes and mode competition in a high-gain free-electron laser including alternating-gradient focusing

    CERN Document Server

    Wu Ju Ha

    2001-01-01

    We solve the eigenvalue problem for a high gain free-electron laser in the 'water-bag' model including alternating-gradient focusing by a variational-solution-based (VSB) expansion method. Such VSB expansion method is very efficient for finding the eigenvalue. The results agree with those obtained by numerical simulation quite well. We further discuss the mode degeneracy and mode competition.

  6. Gain-scheduled Linear Quadratic Control of Wind Turbines Operating at High Wind Speed

    DEFF Research Database (Denmark)

    Østergaard, Kasper Zinck; Stoustrup, Jakob; Brath, Per

    2007-01-01

    This paper addresses state estimation and linear quadratic (LQ) control of variable speed variable pitch wind turbines. On the basis of a nonlinear model of a wind turbine, a set of operating conditions is identified and a LQ controller is designed for each operating point. The controller gains....... Simulation results are given that display good performance of the observers and comparisons with a controller designed by classical methods displays the potential of the method.  ...

  7. Recent Advances on the Design of High-Gain Wideband Operational Transconductance Amplifiers

    Directory of Open Access Journals (Sweden)

    Rida Assaad

    2009-01-01

    greater than 90 dB DC gain, GBW of 325 MHz and better than 70∘ phase margin is discussed. The settling-time- of the NCFF topology can be faster than that of OTAs with Miller compensation. Experimental results for the recycling folded-cascode OTA fabricated in TSMC 0.18 m CMOS, and results of the NCFF demonstrate the efficiency and feasibility of the feed-forward schemes.

  8. Novel T-Z source inverter with high voltage gain and reduced transformer turn ratio

    DEFF Research Database (Denmark)

    Mostaan, Ali; Sharifi Malfejani, Saeed; Soltani, Mohsen

    2015-01-01

    Novel voltage source inverter based on the Z source inverter structure is introduced in this paper. In this new inverter, two inductors of the impedance network in conventional Z source inverter are replaced with two transformers or coupled inductors, but unlike the T-Z source inverter that it's ...... cost. The proposed inverter is analyzed in steady state and its voltage gain is obtained. The performance of the proposed inverter is verified with simulation results using the MATLAB/SIMULINK software....

  9. Pulse Combustor Driven Pressure Gain Combustion for High Efficiency Gas Turbine Engines

    KAUST Repository

    Lisanti, Joel

    2017-02-01

    The gas turbine engine is an essential component of the global energy infrastructure which accounts for a significant portion of the total fossil fuel consumption in transportation and electric power generation sectors. For this reason there is significant interest in further increasing the efficiency and reducing the pollutant emissions of these devices. Conventional approaches to this goal, which include increasing the compression ratio, turbine inlet temperature, and turbine/compressor efficiency, have brought modern gas turbine engines near the limits of what may be achieved with the conventionally applied Brayton cycle. If a significant future step increase in gas turbine efficiency is to be realized some deviation from this convention is necessary. The pressure gain gas turbine concept is a well established new combustion technology that promises to provide a dramatic increase in gas turbine efficiency by replacing the isobaric heat addition process found in conventional technology with an isochoric process. The thermodynamic benefit of even a small increase in stagnation pressure across a gas turbine combustor translates to a significant increase in cycle efficiency. To date there have been a variety of methods proposed for achieving stagnation pressure gains across a gas turbine combustor and these concepts have seen a broad spectrum of levels of success. The following chapter provides an introduction to one of the proposed pressure gain methods that may be most easily realized in a practical application. This approach, known as pulse combustor driven pressure gain combustion, utilizes an acoustically resonant pulse combustor to approximate isochoric heat release and thus produce a rise in stagnation pressure.

  10. High gain semiconductor optical amplifier — Laser diode at visible wavelength

    KAUST Repository

    Shen, Chao

    2017-02-07

    We reported on the first experimental demonstration of a two-section semipolar InGaN-based laser diode with monolithically integrated semiconductor optical amplifier (SOA-LD). The onset of amplification effect was measured at 4V SOA bias (VSOA). The SOA-LD shows a large gain of 5.32 dB at Vsoa = 6 V.

  11. Optimization of Drive Pulse Configuration for a High-Gain Transient X-Ray Laser at 19.6 nm

    Institute of Scientific and Technical Information of China (English)

    LU Xin; LI Ying-Jun; ZHANG Jie

    2001-01-01

    An Ne-like transient collisional excitation x-ray laser at 19.6nm (J = 0 → 1, 3p - 3s) was investigated numerically using a sophisticated hydrodynamic code for a l00μm thick Ge planar target irradiated by a nanosecond pre pulse followed by a picosecond main optical laser pulse. The simulations indicate that for a given peak intensity, the main pulse has an optimal duration to generate the maximum effective gain. An effective gain as high as 200 cma-1 was obtained for the optimized drive pulse configuration.

  12. High-gain dipole antenna using polydimethylsiloxane-glass microsphere (PDMS-GM) substrate for 5G applications

    Science.gov (United States)

    Muhamad, Wan Asilah Wan; Ngah, Razali; Jamlos, Mohd Faizal; Soh, Ping Jack; Ali, Mohd Tarmizi

    2017-01-01

    A new dipole antenna designed using polydimethylsiloxane-glass microsphere (PDMS-GM) substrate is presented. The PDMS-GM substrate offered a lower permittivity of 1.85 compared to pure PDMS of 2.7. This resulted in a wide operating frequency range from 19 GHz up to more than 45 GHz, indicating a bandwidth of more than 28 GHz. The proposed PDMS-GM antenna featured a gain of up to 13.3 dB compared to pure PDMS which only produced 13 GHz of bandwidth and 5.5 dB gain. Instead of wide bandwidth and high gain, the proposed antenna is capable of becoming water resistant by covering its radiator and SMA connector. Such capabilities of the new PDMS-GM antenna indicated suitability for the fifth-generation (5G) wireless communication systems.

  13. Compact tunable high power picosecond source based on Yb-doped fiber amplification of gain switch laser diode.

    Science.gov (United States)

    Liu, Hongjun; Gao, Cunxiao; Tao, Jintao; Zhao, Wei; Wang, Yishan

    2008-05-26

    A compact tunable high power picosecond source based on Yb-doped fiber amplification of gain switch laser diode is demonstrated. A multi-stage single mode Yb-doped fiber preamplifier was combined with a single mode double-clad Yb-doped fiber main amplifier to construct the amplification system, which is seeded by a gain switch laser diode. By optimizing preamplifier???s parameters to compensate the seed spectrum gain, a "flat top" broadband spectrum is obtained to realize wavelength tunable output with a self-made tunable filter. The tunable pulses were further amplified to 3.5 W average power 90 ps pulses at 1 MHz repetition rate, and the center wavelength was tunable in the ranges from 1053 nm to 1073 nm with excellent beam quality.

  14. Seasonal Variations of Polarization Diversity Gain in a Vegetated Area considering High Elevation Angles and a Nomadic User

    Directory of Open Access Journals (Sweden)

    Milan Kvicera

    2015-01-01

    Full Text Available Seasonal variations of the polarization diversity gain are addressed for a nomadic user in a vegetated area taking high elevation angles and nongeostationary satellites into consideration. Corresponding experimental data were obtained at a frequency of 2.0 GHz at Stromovka Park in Prague, the Czech Republic, within the full in-leaf and out-of-leaf periods of 2013 and 2014, respectively. By detecting copolarized and cross-polarized components of the transmitted left- and right-handed circularly polarized signals, the corresponding diversity gain was obtained for multiple-input single-output (MISO, single-input multiple-output (SIMO, and combined MISO/SIMO cases. It was found that tree defoliation results in a significant decrease of the polarization diversity gain achieved for low time percentages in particular scenarios.

  15. Wideband and flat-gain amplifier based on high concentration erbium-doped fibres in parallel double-pass configuration

    Science.gov (United States)

    Hamida, B. A.; Cheng, X. S.; Harun, S. W.; Naji, A. W.; Arof, H.; Al-Khateeb, W.; Khan, S.; Ahmad, H.

    2012-03-01

    A wideband and flat gain erbium-doped fibre amplifier (EDFA) is demonstrated using a hybrid gain medium of a zirconiabased erbium-doped fibre (Zr-EDF) and a high concentration erbium-doped fibre (EDF). The amplifier has two stages comprising a 2-m-long ZEDF and 9-m-long EDF optimised for C- and L-band operations, respectively, in a double-pass parallel configuration. A chirp fibre Bragg grating (CFBG) is used in both stages to ensure double propagation of the signal and thus to increase the attainable gain in both C- and L-band regions. At an input signal power of 0 dBm, a flat gain of 15 dB is achieved with a gain variation of less than 0.5 dB within a wide wavelength range from 1530 to 1605 nm. The corresponding noise figure varies from 6.2 to 10.8 dB within this wavelength region.

  16. Wideband and flat-gain amplifier based on high concentration erbium-doped fibres in parallel double-pass configuration

    Energy Technology Data Exchange (ETDEWEB)

    Hamida, B A; Cheng, X S; Harun, S W; Naji, A W; Arof, H; Al-Khateeb, W; Khan, S; Ahmad, H

    2012-03-31

    A wideband and flat gain erbium-doped fibre amplifier (EDFA) is demonstrated using a hybrid gain medium of a zirconiabased erbium-doped fibre (Zr-EDF) and a high concentration erbium-doped fibre (EDF). The amplifier has two stages comprising a 2-m-long ZEDF and 9-m-long EDF optimised for C- and L-band operations, respectively, in a double-pass parallel configuration. A chirp fibre Bragg grating (CFBG) is used in both stages to ensure double propagation of the signal and thus to increase the attainable gain in both C- and L-band regions. At an input signal power of 0 dBm, a flat gain of 15 dB is achieved with a gain variation of less than 0.5 dB within a wide wavelength range from 1530 to 1605 nm. The corresponding noise figure varies from 6.2 to 10.8 dB within this wavelength region.

  17. Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC).

    Science.gov (United States)

    Zheng, Jie; van de Veerdonk, Frank L; Crossland, Katherine L; Smeekens, Sanne P; Chan, Chun M; Al Shehri, Tariq; Abinun, Mario; Gennery, Andrew R; Mann, Jelena; Lendrem, Dennis W; Netea, Mihai G; Rowan, Andrew D; Lilic, Desa

    2015-10-01

    Signal transducer and activator of transcription 3 (STAT3) triggered production of Th-17 cytokines mediates protective immunity against fungi. Mutations affecting the STAT3/interleukin 17 (IL-17) pathway cause selective susceptibility to fungal (Candida) infections, a hallmark of chronic mucocutaneous candidiasis (CMC). In patients with autosomal dominant CMC, we and others previously reported defective Th17 responses and underlying gain-of-function (GOF) STAT1 mutations, but how this affects STAT3 function leading to decreased IL-17 is unclear. We also assessed how GOF-STAT1 mutations affect STAT3 activation, DNA binding, gene expression, cytokine production, and epigenetic modifications. We excluded impaired STAT3 phosphorylation, nuclear translocation, and sequestration of STAT3 into STAT1/STAT3 heterodimers and confirm significantly reduced transcription of STAT3-inducible genes (RORC/IL-17/IL-22/IL-10/c-Fos/SOCS3/c-Myc) as likely underlying mechanism. STAT binding to the high affinity sis-inducible element was intact but binding to an endogenous STAT3 DNA target was impaired. Reduced STAT3-dependent gene transcription was reversed by inhibiting STAT1 activation with fludarabine or enhancing histone, but not STAT1 or STAT3 acetylation with histone deacetylase (HDAC) inhibitors trichostatin A or ITF2357. Silencing HDAC1, HDAC2, and HDAC3 indicated a role for HDAC1 and 2. Reduced STAT3-dependent gene transcription underlies low Th-17 responses in GOF-STAT1 CMC, which can be reversed by inhibiting acetylation, offering novel targets for future therapies.

  18. Imaging at soft X-ray wavelengths with high-gain microchannel plate detector systems

    Science.gov (United States)

    Timothy, J. Gethyn

    1986-01-01

    Multianode microchannel array (MAMA) detector systems with formats of 256 x 1024 pixels and active areas of 6 x 26 mm are now under evaluation at visible, UV and soft X-ray wavelengths. Very-large-format versions of the MAMA detectors with formats of 2048 x 2048 pixels and active areas of 52 x 52 mm are under development for use in the NASA Goddard Space Telescope Imaging Spectrograph (STIS). Open-structure versions of these detectors with Cs I photocathodes can provide a high-resolution imaging capability at EUV and soft X-ray wavelengths and can deliver a maximum count rate from each array in excess of 10 to the 6th counts/s. In addition, these detector systems have the unique capability to determine the arrival time of a detected photon to an accuracy of 100 ns or better. The construction, mode of operation, and performance characteristics of the MAMA detectors are described, and the program for the development of the very-large-format detectors is outlined.

  19. Study on optical gain of one-dimensional photonic crystals with active impurity

    Institute of Scientific and Technical Information of China (English)

    Zhenghua Li; Tinggen Shen; Xuehua Song; Junfeng Ma; Yong Sheng; Gang Wang

    2007-01-01

    Localized fields in the defect mode of one-dimensional photonic crystals with active impurity are studied with the help of the theory of spontaneous emission from two-level atoms embedded in photonic crystals.Numerical simulations demonstrate that the enhancement of stimulated radiation, as well as the phenomena of transmissivity larger than unity and the abnormality of group velocity close to the edges of photonic band gap, are related to the negative imaginary part of the complex effective refractive index of doped layers. This means that the complex effective refractive index has a negative imaginary part, and that the impurity state with very high quality factor and great state density will occur in the photonic forbidden band if active impurity is introduced into the defect layer properly. Therefore, the spontaneous emission can be enhanced, the amplitude of stimulated emission will be very large and it occurs most probably close to the edges of photonic band gap with the fundamental reason, the group velocity close to the edges of band gap is very small or abnormal.

  20. Different effects of bifeprunox, aripiprazole, and haloperidol on body weight gain, food and water intake, and locomotor activity in rats.

    Science.gov (United States)

    De Santis, Michael; Pan, Bo; Lian, Jiamei; Huang, Xu-Feng; Deng, Chao

    2014-09-01

    Following on the success of Aripiprazole with its high clinical efficacy and minimal side effects, further antipsychotic drugs (such as Bifeprunox) have been developed based on the same dopamine D2 partial agonist pharmacological profile as Aripiprazole. However clinical trials of Bifeprunox have found differing results to that of its predecessor, without the same significant clinical efficacy. This study has therefore investigated the different effects of 10 week treatment with Aripiprazole (0.75 mg/kg, 3 times per day), Bifeprunox (0.8 mg/kg, 3 times per day) and Haloperidol (0.1mg/kg, 3 times per day) on body weight gain, food and water intake, white fat mass, and 8 week treatment on locomotor activity. Treatment with Bifeprunox was found to significantly reduce all of the measured parameters except white fat mass compared to the control group. However, Aripiprazole and Haloperidol treatment reduced water intake compared to the control, without any significant effects on the other measured parameters. These findings further demonstrate the potential pharmacological differences between Aripiprazole and Bifeprunox, and identify potential weight loss side effects and increased anxiety behaviour with Bifeprunox treatment. Copyright © 2014 Elsevier Inc. All rights reserved.

  1. Stability of Gain Scheduling Control for Aircraft with Highly Nonlinear Behavior

    Directory of Open Access Journals (Sweden)

    Fany Mendez-Vergara

    2014-01-01

    Full Text Available The main goal of this work is to study the stability properties of an aircraft with nonlinear behavior, controlled using a gain scheduled approach. An output feedback is proposed which is able to guarantee asymptotical stability of the task-coordinates origin and safety of the operation in the entire flight envelope. The results are derived using theory of hybrid and singular perturbed systems. It is demonstrated that both body velocity and orientation asymptotic tracking can be obtained in spite of nonlinearities and uncertainty. The results are illustrated using numerical simulations in F16 jet.

  2. An ultra-low voltage high gain operational transconductance amplifier for biomedical applications

    OpenAIRE

    Bautista, F.; Martınez, S.O.; Dieck, G.; Rossetto, O.

    2007-01-01

    special issue in one of the Eurasip journals (Hindawi Publishing Corporation); International audience; A novel differential-input single-output Operational Transconductance Amplifier (OTA) is presented in this paper. The topology proposed consists of an input stage based on a folded cascoded amplifier, and an output stage based on a current source amplifier and a bulk-driven current mirror. The simulations show that the amplifier has a 1.94¹W power dissipation, 92dB open-loop DC gain, a unit ...

  3. 93-133 GHz Band InP High-Electron-Mobility Transistor Amplifier with Gain-Enhanced Topology

    Science.gov (United States)

    Sato, Masaru; Shiba, Shoichi; Matsumura, Hiroshi; Takahashi, Tsuyoshi; Nakasha, Yasuhiro; Suzuki, Toshihide; Hara, Naoki

    2013-04-01

    In this study, we developed a new type of high-frequency amplifier topology using 75-nm-gate-length InP-based high-electron-mobility transistors (InP HEMTs). To enhance the gain for a wide frequency range, a common-source common-gate hybrid amplifier topology was proposed. A transformer-based balun placed at the input of the amplifier generates differential signals, which are fed to the gate and source terminals of the transistor. The amplified signal is outputted at the drain node. The simulation results show that the hybrid topology exhibits a higher gain from 90 to 140 GHz than that of the conventional common-source or common-gate amplifier. The two-stage amplifier fabricated using the topology exhibits a small signal gain of 12 dB and a 3-dB bandwidth of 40 GHz (93-133 GHz), which is the largest bandwidth and the second highest gain reported among those of published 120-GHz-band amplifiers. In addition, the measured noise figure was 5 dB from 90 to 100 GHz.

  4. Normal hematopoiesis and lack of β-catenin activation in osteoblasts of patients and mice harboring Lrp5 gain-of-function mutations

    DEFF Research Database (Denmark)

    Galán-Díez, Marta; Isa, Adiba; Ponzetti, Marco;

    2016-01-01

    of hematopoiesis and leukemogenic properties of β-catenin activation in osteoblasts, that lead to development of acute myeloid leukemia (AML). Using mice with gain-of-function (GOF) Lrp5 alleles (Lrp5(A214V)) that recapitulate the human high bone mass (HBM) phenotype, as well as patients with the T253I HBM Lrp5...... patients showed normal hematopoiesis, normal percentage of myeloid cells, and lack of anemia. We conclude that Lrp5 GOF mutations do not activate β-catenin signaling in osteoblasts. As a result, myeloid lineage differentiation is normal in HBM patients and mice. This article is part of a Special Issue...

  5. High-gain step-profiled integrated diagonal horn-antennas

    Science.gov (United States)

    Eleftheriades, George V.; Rebeiz, Gabriel M.

    1992-05-01

    A new step-profiled integrated-horn antenna is proposed. The antenna allows gains in the range of 17-20 dB to be achieved using standard (100) silicon wafers. The antenna is diagonally fed and exhibits very good circular symmetry within the 10-dB beamwidth. It has a fundamental Gaussian coupling efficiency of 83 percent. It is demonstrated that the profiled antenna has a radiation pattern similar to that of its smooth envelope horn, provided that the discontinuity between successive wafers does not exceed 0.15 lambda. The integrated stepped-profile horn performs much better than a corresponding smooth 70 deg flare-angle integrated horn of the same aperture size. The integrated step-profile horn is very well-suited for radio-astonomical and remote-sensing millimeter-wave imaging arrays requiring a large number of focal-plane elements.

  6. High temperature and wavelength dependence of avalanche gain of AlAsSb avalanche photodiodes.

    Science.gov (United States)

    Sandall, Ian C; Xie, Shiyu; Xie, Jingjing; Tan, Chee Hing

    2011-11-01

    The evolution of the dark currents and breakdown at elevated temperatures of up to 450  K are studied using thin AlAsSb avalanche regions. While the dark currents increase rapidly as the temperature is increased, the avalanche gain is shown to only have a weak temperature dependence. Temperature coefficients of breakdown voltage of 0.93 and 1.93  mV/K were obtained from the diodes of 80 and 230  nm avalanche regions (i-regions), respectively. These values are significantly lower than for other available avalanche materials at these temperatures. The wavelength dependence of multiplication characteristics of AlAsSb p-i-n diodes has also been investigated, and it was found that the ionization coefficients for electrons and holes are comparable within the electric field and wavelength ranges measured.

  7. A novel broadband and high-gain microstrip reflectarray antenna with variable polarization

    Institute of Scientific and Technical Information of China (English)

    Zhihang WU; Wenxun ZHANG; Zhenguo LIU; Wei SHEN

    2008-01-01

    This article proposes a new kind of microstrip reflectarray antenna, of which the polarization could be reconfigured among all the polarization states instead of some fixed states in a dual- or multi-polarized antenna. The mechanism for polarized variability is so simple that only mechanical rotation is needed. Theoretical analysis shows that the refected polarization covers all states and that the dual- or multi-layered unit structure sandwiched with air-gaps can broaden the bandwidth efficiently. Moreover, it is demonstrated that adopting more elements can enhance antenna gain. With these advanta-geous features, this kind of antenna has the potential significance for engineering applications in radar, com-munication, etc. In this article, a complete theoretical analysis as well as a specific design sample is given to verify this method.

  8. Excess Folic Acid Increases Lipid Storage, Weight Gain, and Adipose Tissue Inflammation in High Fat Diet-Fed Rats

    Science.gov (United States)

    Kelly, Karen B.; Kennelly, John P.; Ordonez, Marta; Nelson, Randal; Leonard, Kelly; Stabler, Sally; Gomez-Muñoz, Antonio; Field, Catherine J.; Jacobs, René L.

    2016-01-01

    Folic acid intake has increased to high levels in many countries, raising concerns about possible adverse effects, including disturbances to energy and lipid metabolism. Our aim was to investigate the effects of excess folic acid (EFA) intake compared to adequate folic acid (AFA) intake on metabolic health in a rodent model. We conducted these investigations in the setting of either a 15% energy low fat (LF) diet or 60% energy high fat (HF) diet. There was no difference in weight gain, fat mass, or glucose tolerance in EFA-fed rats compared to AFA-fed rats when they were fed a LF diet. However, rats fed EFA in combination with a HF diet had significantly greater weight gain and fat mass compared to rats fed AFA (p adipose tissue of high fat-excess folic acid (HF-EFA) fed rats. Inflammation was increased in HF-EFA fed rats, associated with impaired glucose tolerance compared to high fat-adequate folic acid (HF-AFA) fed rats (p < 0.05). In addition, folic acid induced PPARγ expression and triglyceride accumulation in 3T3-L1 cells. Our results suggest that excess folic acid may exacerbate weight gain, fat accumulation, and inflammation caused by consumption of a HF diet. PMID:27669293

  9. Does Structured Quizzing with Process Specific Feedback Lead to Learning Gains in an Active Learning Geoscience Classroom?

    Science.gov (United States)

    Palsole, S.; Serpa, L. F.

    2013-12-01

    There is a great realization that efficient teaching in the geosciences has the potential to have far reaching effects in outreach to decision and policy makers (Herbert, 2006; Manduca & Mogk, 2006). This research in turn informs educators that the geosciences by the virtue of their highly integrative nature play an important role in serving as an entry point into STEM disciplines and helping developing a new cadre of geoscientists, scientists and a general population with an understanding of science. Keeping these goals in mind we set to design introductory geoscience courses for non-majors and majors that move away from the traditional lecture models which don't necessarily contribute well to knowledge building and retention ((Handelsman et al., 2007; Hake, 1997) to a blended active learning classroom where basic concepts and didactic information is acquired online via webquests, lecturettes and virtual field trips and the face to face portions of the class are focused on problem solving exercises. The traditional way to ensure that students are prepared for the in-class activity is to have the students take a quiz online to demonstrate basic competency. In the process of redesign, we decided to leverage the technology to build quizzes that are highly structured and map to a process (formation of divergent boundaries for example) or sets of earth processes that we needed the students to know before in-class activities. The quizzes can be taken multiple times and provide process specific feedback, thus serving as a heuristic to the students to ensure they have acquired the necessary competency. The heuristic quizzes were developed and deployed over a year with the student data driving the redesign process to ensure synchronicity. Preliminary data analysis indicates a positive correlation between higher student scores on in-class application exercises and time spent on the process quizzes. An assessment of learning gains also indicate a higher degree of self

  10. High-gain direct-drive inertial confinement fusion for the Laser Mégajoule: recent progress

    Science.gov (United States)

    Canaud, B.; Garaude, F.; Ballereau, P.; Bourgade, J. L.; Clique, C.; Dureau, D.; Houry, M.; Jaouen, S.; Jourdren, H.; Lecler, N.; Masse, L.; Masson, A.; Quach, R.; Piron, R.; Riz, D.; Van der Vliet, J.; Temporal, M.; Delettrez, J. A.; McKenty, P. W.

    2007-12-01

    Recent progress in high-gain direct-drive inertial confinement fusion with the laser Mégajoule is reviewed. A new baseline direct-drive target design is presented which implodes with a two-cones irradiation pattern of indirect-drive beam configuration and zooming. Perturbation amplitudes and correlated growth rates of hydrodynamic instabilities in the compressed core of a directly driven inertial confinement fusion capsule are analyzed in planar and spherical geometries, with and without heat conduction, in the unsteady state regime of the deceleration. Shock propagation in heterogeneous media is addressed in the context of first shock. The neutron and photon emissions of high-gain direct-drive target are characterized. Numerical interpretations of directly driven homothetic cryogenic D2 target implosion experiments on the Omega facility are presented.

  11. High magnetic shear gain in a liquid sodium stable couette flow experiment A prelude to an alpha - omega dynamo

    Energy Technology Data Exchange (ETDEWEB)

    Colgate, Stirling [Los Alamos National Laboratory; Li, Jui [Los Alamos National Laboratory; Finn, John [Los Alamos National Laboratory; Pariev, Vladimir [Los Alamos National Laboratory; Beckley, Howard [NM INSTIT. OF MINING AND TECH; Si, Jiahe [NM INSTIT. OF MINING AND TECH.; Martinic, Joe [NM INSTIT. OF MINING AND TECH.; Westpfahl, David [NM INSTIT. OF TECH.; Slutz, James [NM INSTIT. OF MINING AND TECH.; Westrom, Zeb [NM INSTIT. OF TECH.; Klein, Brianna [NM INSTIT. OF MINING AND TECH.

    2010-11-08

    The {Omega}-phase of the liquid sodium {alpha}-{Omega} dynamo experiment at NMIMT in cooperation with LANL has successfully demonstrated the production of a high toroidal field, B{sub {phi}} {approx_equal} 8 x B{sub r} from the radial component of an applied poloidal magnetic field, B{sub r}. This enhanced toroidal field is produced by rotational shear in stable Couette Row within liquid sodium at Rm {approx_equal} 120. The small turbulence in stable Taylor-Couette Row is caused by Ekman Row where ({delta}v/v){sup 2} {approx} 10{sup -3}. This high {Omega}-gain in low turbulence flow contrasts with a smaller {Omega}-gain in higher turbulence, Helmholtz-unstable shear flows. This result supports the ansatz that large scale astrophysical magnetic fields are created within semi-coherent large scale motions in which turbulence plays a diffusive role that enables magnetic flux linkage.

  12. High Magnetic Shear Gain in a Liquid Sodium Stable Couette Flow Experiment; A Prelude to an alpha-Omega Dynamo

    CERN Document Server

    Colgate, Stirling A; Pariev, Vladimir; Finn, John; Beckley, Howard; Si, Jiahe; Martinic, Joe; Westpfahl, David; Slutz, James; Westrom, Cebastian; Klein, Brianna; Schendel, Paul; Scharle, Cletus; McKinney, Travis; Ginanni, Rocky; Bentley, Ian; Mickey, Timothy

    2010-01-01

    The $\\Omega$-phase of the liquid sodium $\\alpha$-$\\Omega$ dynamo experiment at NMIMT in cooperation with LANL has successfully demonstrated the production of a high toroidal field, $B_{\\phi} \\simeq 8\\times B_r$ from the radial component of an applied poloidal magnetic field, $B_r$. This enhanced toroidal field is produced by rotational shear in stable Couette flow within liquid sodium at $Rm \\simeq 120$. The small turbulence in stable Taylor-Couette flow is caused by Ekman flow where $ (\\delta v/v)^2 \\sim 10^{-3} $. This high $\\Omega$-gain in low turbulence flow contrasts with a smaller $\\Omega$-gain in higher turbulence, Helmholtz-unstable shear flows. This result supports the ansatz that large scale astrophysical magnetic fields are created within semi-coherent large scale motions in which turbulence plays only a smaller diffusive role that enables magnetic flux linkage.

  13. On the Fielding of a High Gain, Shock-Ignited Target on the National Ignitiion Facility in the Near Term

    Energy Technology Data Exchange (ETDEWEB)

    Perkins, L J; Betti, R; Schurtz, G P; Craxton, R S; Dunne, A M; LaFortune, K N; Schmitt, A J; McKenty, P W; Bailey, D S; Lambert, M A; Ribeyre, X; Theobald, W R; Strozzi, D J; Harding, D R; Casner, A; Atzemi, S; Erbert, G V; Andersen, K S; Murakami, M; Comley, A J; Cook, R C; Stephens, R B

    2010-04-12

    Shock ignition, a new concept for igniting thermonuclear fuel, offers the possibility for a near-term ({approx}3-4 years) test of high gain inertial confinement fusion on the National Ignition Facility at less than 1MJ drive energy and without the need for new laser hardware. In shock ignition, compressed fusion fuel is separately ignited by a strong spherically converging shock and, because capsule implosion velocities are significantly lower than those required for conventional hotpot ignition, fusion energy gains of {approx}60 may be achievable on NIF at laser drive energies around {approx}0.5MJ. Because of the simple all-DT target design, its in-flight robustness, the potential need for only 1D SSD beam smoothing, minimal early time LPI preheat, and use of present (indirect drive) laser hardware, this target may be easier to field on NIF than a conventional (polar) direct drive hotspot ignition target. Like fast ignition, shock ignition has the potential for high fusion yields at low drive energy, but requires only a single laser with less demanding timing and spatial focusing requirements. Of course, conventional symmetry and stability constraints still apply. In this paper we present initial target performance simulations, delineate the critical issues and describe the immediate-term R&D program that must be performed in order to test the potential of a high gain shock ignition target on NIF in the near term.

  14. Excess Folic Acid Increases Lipid Storage, Weight Gain, and Adipose Tissue Inflammation in High Fat Diet-Fed Rats.

    Science.gov (United States)

    Kelly, Karen B; Kennelly, John P; Ordonez, Marta; Nelson, Randal; Leonard, Kelly; Stabler, Sally; Gomez-Muñoz, Antonio; Field, Catherine J; Jacobs, René L

    2016-09-23

    Folic acid intake has increased to high levels in many countries, raising concerns about possible adverse effects, including disturbances to energy and lipid metabolism. Our aim was to investigate the effects of excess folic acid (EFA) intake compared to adequate folic acid (AFA) intake on metabolic health in a rodent model. We conducted these investigations in the setting of either a 15% energy low fat (LF) diet or 60% energy high fat (HF) diet. There was no difference in weight gain, fat mass, or glucose tolerance in EFA-fed rats compared to AFA-fed rats when they were fed a LF diet. However, rats fed EFA in combination with a HF diet had significantly greater weight gain and fat mass compared to rats fed AFA (p folic acid (HF-EFA) fed rats. Inflammation was increased in HF-EFA fed rats, associated with impaired glucose tolerance compared to high fat-adequate folic acid (HF-AFA) fed rats (p folic acid induced PPARγ expression and triglyceride accumulation in 3T3-L1 cells. Our results suggest that excess folic acid may exacerbate weight gain, fat accumulation, and inflammation caused by consumption of a HF diet.

  15. Quercetin decreases high-fat diet induced body weight gain and accumulation of hepatic and circulating lipids in mice.

    Science.gov (United States)

    Hoek-van den Hil, E F; van Schothorst, E M; van der Stelt, I; Swarts, H J M; Venema, D; Sailer, M; Vervoort, J J M; Hollman, P C H; Rietjens, I M C M; Keijer, J

    2014-09-01

    Dietary flavonoids may protect against cardiovascular diseases (CVD). Increased circulating lipid levels and hepatic lipid accumulation are known risk factors for CVD. The aim of this study was to investigate the effects and underlying molecular mechanisms of the flavonoid quercetin on hepatic lipid metabolism in mice with high-fat diet induced body weight gain and hepatic lipid accumulation. Adult male mice received a 40 energy% high-fat diet without or with supplementation of 0.33 % (w/w) quercetin for 12 weeks. Body weight gain was 29 % lower in quercetin fed mice (p lipid accumulation to 29 % of the amount present in the control mice (p lipid profiling revealed that the supplementation significantly lowered serum lipid levels. Global gene expression profiling of liver showed that cytochrome P450 2b (Cyp2b) genes, key target genes of the transcription factor constitutive androstane receptor (Car; official symbol Nr1i3), were downregulated. Quercetin decreased high-fat diet induced body weight gain, hepatic lipid accumulation and serum lipid levels. This was accompanied by regulation of cytochrome P450 2b genes in liver, which are possibly under transcriptional control of CAR. The quercetin effects are likely dependent on the fat content of the diet.

  16. PPARy activity in subcutaneous abdominal fat tissue and fat mass gain during short-term overfeeding

    NARCIS (Netherlands)

    Joosen, A.M.C.P.; Bakker, A.H.F.; Zorenc, A.H.G.; Kersten, A.H.; Schrauwen, P.; Westerterp, K.R.

    2006-01-01

    Objective: As the peroxisome proliferator-activated receptor (PPAR) plays a central role in fat mass regulation, we investigated whether initial subcutaneous PPAR activity is related to fat mass generation during overfeeding. Subjects: Fourteen healthy female subjects (age 254 years, BMI 22.12.3

  17. Determinants of Developmental Gain in Daily Activities in Young Children with Cerebral Palsy.

    Science.gov (United States)

    Kruijsen-Terpstra, Anne J A; Ketelaar, Marjolijn; Verschuren, Olaf; Smits, Dirk-Wouter; Jongmans, Marian J; Gorter, Jan Willem

    2014-09-18

    ABSTRACT The aim of this study was to examine which child and family characteristics at the child's age of 2 years are determinants of development of self-care and mobility activities over a period of 2 years in young children with cerebral palsy (CP). Longitudinal data of 92 children, representing all levels of the Gross Motor Function Classification System (GMFCS), were analyzed. Children's self-care and mobility activities were assessed with the Functional Skills Scale of the Pediatric Evaluation of Disability Inventory. Development of self-care and mobility activities was related to several child determinants but no family determinants. GMFCS, type of CP, intellectual capacity, and epilepsy were related to the development of self-care and mobility activities, while manual ability and spasticity were related to development of mobility activities. Multivariate analysis indicated that GMFCS and intellectual capacity were the strongest determinants of development of self-care activities, and GMFCS was the strongest determinant of development of mobility activities. The change in self-care and mobility activities was less favorable in severely affected children with severe disability. Knowledge of GMFCS level and intellectual capacity is important in anticipating change over time and goal setting in young children with CP.

  18. High-gain cryogenic amplifier assembly employing a commercial CMOS operational amplifier.

    Science.gov (United States)

    Proctor, J E; Smith, A W; Jung, T M; Woods, S I

    2015-07-01

    We have developed a cryogenic amplifier for the measurement of small current signals (10 fA-100 nA) from cryogenic optical detectors. Typically operated with gain near 10(7) V/A, the amplifier performs well from DC to greater than 30 kHz and exhibits noise level near the Johnson limit. Care has been taken in the design and materials to control heat flow and temperatures throughout the entire detector-amplifier assembly. A simple one-board version of the amplifier assembly dissipates 8 mW to our detector cryostat cold stage, and a two-board version can dissipate as little as 17 μW to the detector cold stage. With current noise baseline of about 10 fA/(Hz)(1/2), the cryogenic amplifier is generally useful for cooled infrared detectors, and using blocked impurity band detectors operated at 10 K, the amplifier enables noise power levels of 2.5 fW/(Hz)(1/2) for detection of optical wavelengths near 10 μm.

  19. Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Woo Young; Bae, Ki Beom; Kim, Sung Hyun; Yu, Dong Hun; Kim, Hei Jung; Ji, Young Rae; Park, Seo Jin; Park, Si Jun; Kang, Min-Cheol; Jeong, Ja In [School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701 (Korea, Republic of); Park, Sang-Joon [College of Veterinary Medicine, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701 (Korea, Republic of); Lee, Sang Gyu [School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701 (Korea, Republic of); Lee, Inkyu [School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 700-842 (Korea, Republic of); Kim, Myoung Ok [School of Animal BT Sciences, Sangju Campus, Kyungpook National University, 386 Gajang-dong, Sangju, Gyeongsangbuk-do 742-211 (Korea, Republic of); Yoon, Duhak, E-mail: dhyoon@knu.ac.kr [School of Animal BT Sciences, Sangju Campus, Kyungpook National University, 386 Gajang-dong, Sangju, Gyeongsangbuk-do 742-211 (Korea, Republic of); Ryoo, Zae Young, E-mail: jaewoong64@hanmail.net [School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701 (Korea, Republic of)

    2014-02-14

    Highlights: • The expression of Jazf1 in the liver suppressed lipid accumulation. • Jazf1 significantly increases transcription of fatty acid synthase. • Jazf1 plays a critical role in the regulation of energy and lipid homeostasis. • Jazf1 associates the development of metabolic disorder. • Jazf1 may provide a new therapeutic target in the management of metabolic disorder. - Abstract: Jazf1 is a 27 kDa nuclear protein containing three putative zinc finger motifs that is associated with diabetes mellitus and prostate cancer; however, little is known about the role that this gene plays in regulation of metabolism. Recent evidence indicates that Jazf1 transcription factors bind to the nuclear orphan receptor TR4. This receptor regulates PEPCK, the key enzyme involved in gluconeogenesis. To elucidate Jazf1’s role in metabolism, we fed a 60% fat diet for up to 15 weeks. In Jazf1 overexpression mice, weight gain was found to be significantly decreased. The expression of Jazf1 in the liver also suppressed lipid accumulation and decreased droplet size. These results suggest that Jazf1 plays a critical role in the regulation of lipid homeostasis. Finally, Jazf1 may provide a new therapeutic target in the management of obesity and diabetes.

  20. Local expectation violations result in global activity gain in primary visual cortex.

    Science.gov (United States)

    Kok, Peter; van Lieshout, Lieke L F; de Lange, Floris P

    2016-11-22

    During natural perception, we often form expectations about upcoming input. These expectations are usually multifaceted - we expect a particular object at a particular location. However, expectations about spatial location and stimulus features have mostly been studied in isolation, and it is unclear whether feature-based expectation can be spatially specific. Interestingly, feature-based attention automatically spreads to unattended locations. It is still an open question whether the neural mechanisms underlying feature-based expectation differ from those underlying feature-based attention. Therefore, establishing whether the effects of feature-based expectation are spatially specific may inform this debate. Here, we investigated this by inducing expectations of a specific stimulus feature at a specific location, and probing the effects on sensory processing across the visual field using fMRI. We found an enhanced sensory response for unexpected stimuli, which was elicited only when there was a violation of expectation at the specific location where participants formed a stimulus expectation. The neural consequences of this expectation violation, however, spread to cortical locations processing the stimulus in the opposite hemifield. This suggests that an expectation violation at one location in the visual world can lead to a spatially non-specific gain increase across the visual field.

  1. Do all sedentary activities lead to weight gain: sleep does not.

    Science.gov (United States)

    Chaput, Jean-Philippe; Klingenberg, Lars; Sjödin, Anders

    2010-11-01

    To discuss the benefits of having a good night's sleep for body weight stability. Experimental studies have shown that short-term partial sleep restriction decreases glucose tolerance, increases sympathetic tone, elevates cortisol concentrations, decreases the satiety hormone leptin, increases the appetite-stimulating hormone ghrelin, and increases hunger and appetite. Short sleep duration might increase the risk of becoming obese, because it does not allow the recovery of a hormonal profile facilitating appetite control. Lack of sleep could also lead to weight gain and obesity by increasing the time available for eating and by making the maintenance of a healthy lifestyle more difficult. Furthermore, the increased fatigue and tiredness associated with sleeping too little could lessen one's resolve to follow exercise regimens. Short sleep duration appears to be a novel and independent risk factor for obesity. With the growing prevalence of chronic sleep restriction, any causal association between reduced sleep and obesity would have substantial importance from a public health standpoint. Future research is needed to determine whether sleep extension in sleep-deprived obese individuals will influence appetite control and/or reduce the amount of body fat.

  2. [Cyanidin-3-glucoside attenuates body weight gain, serum lipid concentrations and insulin resistance in high-fat diet-induced obese rats].

    Science.gov (United States)

    Yu, Ren-Qiang; Wu, Xiao-You; Zhou, Xiang; Zhu, Jing; Ma, Lu-Yi

    2014-05-01

    Cyanidin-3-glucoside (C3G) is the main active ingredient of anthocyanidin. This study aimed to evaluate the effects of C3G on body weight gain, visceral adiposity, lipid profiles and insulin resistance in high-fat diet-induced obese rats. Thirty male Sprague-Dawley rats were randomly divided into a control group (n=8) and a high fat diet group (n=22), and were fed with standard diet or high fat diet. Five weeks later, 17 high-fat diet-induced obese rats were randomly given C3G [100 mg/(kg·d)] or normal saline via intragastric administration for 5 weeks. Five weeks later, body weight, visceral adiposity and food intake were measured. Blood samples were collected for detecting fasting glucose, serum insulin, lipid profiles and adiponectin. Insulin resistance index, atherosclerosis index and average feed efficiency ratio were calculated. C3G supplementation markedly decreased body weight, visceral adiposity, average feed efficiency ratio, triglyceride, total cholesterol, low density lipoprotein cholesterol, fasting glucose, serum insulin, insulin resistance index and atherosclerosis index in high-fat diet-induced obese rats. C3G supplementation normalized serum adiponectin and high density lipoprotein cholesterol levels in high-fat diet-induced obese rats. Cyanidin-3-glucoside can reduce body weight gain, and attenuate obesity-associated dyslipidemia and insulin resistance in high-fat diet-fed rats via up-regulating serum adiponectin level.

  3. Alkali-activated fly ash. Relationship between mechanical strength gains and initial ash chemistry

    Directory of Open Access Journals (Sweden)

    Palomo, A.

    2008-09-01

    Full Text Available Alkali-activated fly ash is the primary component of a new generation of high-strength, durable binders with excellent mechanical properties and durability (on occasion bettering traditional Portland cement performance. Moreover, development of these cements may contribute to mitigating CO2 emissions, since the base material is an industrial by-product. The present study was conducted to determine the effect of the composition of the initial materials (SiO2/Al2O3 and Na2O/Al2O3 ratios on the mechanical properties, nature and composition of the reaction products. The results obtained indicate that there is no linear relationship between these ratios and mechanical strength, but rather a series of optimal values above and below which strength declines. In the specific case of the ratios studied in the present paper, these values were: SiO2/Al2O3= 4.0 and Na2O/Al2O3= 1.0 (molar ratios.Las cenizas volantes activadas alcalinamente constituyen la base de una nueva generación de cementos con muy interesantes propiedades mecánicas, adherentes y durables (a veces incluso mejores que las de los cementos Portland tradicionales. Adicionalmente el desarrollo de estos cementos podría contribuir a mitigar las emisiones de CO2 a la atmósfera, ya que el material base de los mismos puede estar formado por subproductos industriales. En la presente investigación se realizó un estudio para determinar la influencia de la composición de los materiales iniciales (ratios SiO2/Al2O3 y Na2O/Al2O3 en las propiedades mecánicas y en la naturaleza y composición de los productos de reacción. Los resultados obtenidos indican que no existe una relación lineal de dichas ratios con las resistencias mecánicas, sino que existen unos valores óptimos, por encima y debajo de los cuales las resistencias mecánicas disminuyen. En el caso concreto de las ratios estudiadas en el presente trabajo estos valores serian: SiO2/Al2O3= 4,0 y Na2O/Al2O3= 1,0 (relaciones molares

  4. FUSING PASSIVE AND ACTIVE SENSED IMAGES TO GAIN INFRARED-TEXTURED 3D MODELS

    OpenAIRE

    Weinmann, M.; Hoegner, L.; Leitloff, J.; U. Stilla; Hinz, S.; Jutzi, B.

    2012-01-01

    Obtaining a 3D description of man-made and natural environments is a basic task in Computer Vision, Photogrammetry and Remote Sensing. New active sensors provide the possibility of capturing range information by images with a single measurement. With this new technique, image-based active ranging is possible which allows for capturing dynamic scenes, e.g. with moving pedestrians or moving vehicles. The currently available range imaging devices usually operate within the close-infrare...

  5. Modified High Gain APDs for Multi-beam Ladar Instrumentation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this effort, Radiation Monitoring Devices, Inc (RMD) addresses NASA's request for sensitive, high quantum efficiency (QE) optical detectors for space- and...

  6. "Gaining Power through Education": Experiences of Honduran Students from High Poverty Backgrounds

    Science.gov (United States)

    Mather, Peter C.; Zempter, Christy; Ngumbi, Elizabeth; Nakama, Yuki; Manley, David; Cox, Haley

    2017-01-01

    This is a study of students from high-poverty backgrounds attending universities in Honduras. Based on a series of individual and focus group interviews, the researchers found students from high-poverty backgrounds face numerous practical challenges in persisting in higher education. Despite these challenges, participants succeeded due to a…

  7. Field Plate Optimization in Low-Power High-Gain Source-Gated Transistors

    NARCIS (Netherlands)

    Sporea,R.A.; Trainor, M.J.; Young, N.D.; Shannon, J.M.; Silva, S.R.P.

    2012-01-01

    Source-gated transistors (SGTs) have potentially very high output impedance and low saturation voltages, which make them ideal as building blocks for high performance analog circuits fabricated in thin-film technologies. The quality of the saturation is greatly influenced by the design of the field-

  8. Temperature dependency of the Ga/In distribution in Cu(In,Ga)Se2 absorbers in high temperature processes

    Science.gov (United States)

    Mueller, B. J.; Demes, T.; Lill, P. C.; Haug, V.; Hergert, F.; Zweigart, S.; Herr, U.

    2016-05-01

    The current article reports about the influence of temperature and glass substrate on Ga/In interdiffusion and chalcopyrite phase formation in the stacked elemental layer process. According to the Shockley-Queisser limit the optimum for single junction devices is near 1.4 eV, which is strongly coupled on the Ga/(Ga+In) ratio of Cu(In,Ga)Se2 thin film solar cells. To increase the Ga content in the active region of the Cu(In,Ga)Se2 a 70:30 CuGa alloy target is used. An increase of the selenization temperature leads to a more homogeneous Ga/In distribution and a less pronounced Ga agglomeration at the back contact. The Ga/In interdiffusion rates for different selenization temperatures and substrates were estimated with the model of a two layer system. At the highest selenization temperature used an absorber band gap of 1.12 eV was realized, which is similar to typical values of absorbers produced during the co-evaporation process. The Na diffusion into the Cu(In,Ga)Se2 is weakly temperature dependent but strongly influenced by the choice of the glass substrate composition.

  9. A novel 3-stage structure for a low-noise, high-gain and gain-flattened L-band erbium doped fiber amplifier

    Institute of Scientific and Technical Information of China (English)

    强则煊; 何赛灵; 张徐亮; 沈林放

    2004-01-01

    The configuration of the novel three-stage L-band erbium-doped fiber amplifier with very large and flat gain and very low noise figure presented in this paper uses the forward ASE (amplified spontaneous emission) from the first section of the EDF (erbium-doped fiber) and the backward ASE from the third section of the EDF (both serve as the secondary pump sources of energy) to pump the second EDF. To improve the pump efficiency, the power of the pump is split into two parts (with a ratio of e.g. 2:7). The characteristics of this L-band EDFA are studied on the basis of the Giles Model with ASE.

  10. A novel 3-stage structure for a low-noise, high-gain and gain-flattened L-band erbium doped fiber amplifier

    Institute of Scientific and Technical Information of China (English)

    强则煊; 何赛灵; 张徐亮; 沈林放

    2004-01-01

    The configuration of the novel three-stage L-band erbium-doped fiber amplifier with very large and flat gain and very low noise figure presented in this paper uses the forward ASE (amplified spontaneous emission) from the first section of the EDF (erbium-doped fiber) and the backward AS E from the third section of the EDF (both serve as the secondary pump sources of energy) to pump the second EDF. To improve the pump efficiency, the power of the pump is split into two parts(with a ratio of e.g. 2:7). The characteristics of this L-band EDFA are studied on the basis of the Giles Model with ASE.

  11. Determinants of Developmental Gain in Daily Activities in Young Children with Cerebral Palsy

    NARCIS (Netherlands)

    Kruijsen-Terpstra, Anne J A; Ketelaar, Marjolijn; Verschuren, Olaf; Smits, Dirk-Wouter; Jongmans, Marian J; Gorter, Jan Willem

    2015-01-01

    The aim of this study was to examine which child and family characteristics at the child's age of 2 years are determinants of development of self-care and mobility activities over a period of 2 years in young children with cerebral palsy (CP). Longitudinal data of 92 children, representing all level

  12. Determinants of developmental gain in daily activities in young children with cerebral palsy

    NARCIS (Netherlands)

    Kruijsen-Terpstra, Anne JA; Ketelaar, Marjolijn; Verschuren, Olaf; Smits, Dirk-Wouter; Jongmans, Marian J; Gorter, Jan Willem

    2015-01-01

    The aim of this study was to examine which child and family characteristics at the child's age of 2 years are determinants of development of self-care and mobility activities over a period of 2 years in young children with cerebral palsy (CP). Longitudinal data of 92 children, representing all level

  13. High Adherence to CPAP Treatment Does Not Prevent the Continuation of Weight Gain among Severely Obese OSAS Patients

    Science.gov (United States)

    Myllylä, Minna; Kurki, Samu; Anttalainen, Ulla; Saaresranta, Tarja; Laitinen, Tarja

    2016-01-01

    Study Objectives: Obstructive sleep apnea syndrome (OSAS) patients benefit from continuous positive airway pressure (CPAP) treatment in a dose-response manner. We determined adherence and weight control, as well as their predictors, among long-term CPAP users. Methods: Cohort of 1,023 OSAS patients had used CPAP on average of 6.6 ± 1.2 years. BMI was determined at baseline and at follow-up visits. There were 7.4 ± 1.7 BMI and 6.5 ± 1.8 CPAP usage measurements per patient on average. Using the Bayesian hierarchical model, we determined the patients' individual trends of BMI and adherence development. Patients with significantly increasing or decreasing trends were identified at the posterior probability level of > 90%. Results: The mean age in the cohort was 55.6 ± 9.8 years, BMI 33.5 ± 6.4 kg/m2, apnea-hypopnea index 33.7 ± 23.1, and CPAP usage 6.0 ± 1.8 h/day. The majority of patients had no significant change in BMI (mean annual weight gain 0.04 ± 0.29 kg/m2) or CPAP adherence (mean annual increase 11.4 ± 7.0 min/day). However, at the individual level, 10% of the patients showed significant annual weight gain (0.63 ± 0.35 kg/m2) during the 5-year follow-up period. At baseline these patients were already more severely obese (mean BMI 40.0 ± 5.9 kg/m2) despite being younger (mean 50.9 ± 9.5 years) than the rest of the cohort. Conclusions: In the majority of CPAP-treated OSAS patients, weight did not significantly change but gained slightly slower than in age-matched population in general. However, in 10% of patients, high adherence to CPAP treatment did not prevent the continuation of weight gain. These patients present a high-risk group for OSAS-related multimorbidity later in life. Citation: Myllylä M, Kurki S, Anttalainen U, Saaresranta T, Laitinen T. High adherence to CPAP treatment does not prevent the continuation of weight gain among severely obese OSAS patients. J Clin Sleep Med 2016;12(4):519–528. PMID:26888588

  14. Analog time-reversed ultrasonically encoded (TRUE) optical focusing inside scattering media with high power gain (Conference Presentation)

    Science.gov (United States)

    Ma, Cheng; Xu, Xiao; Wang, Lihong V.

    2016-03-01

    Focusing light deep inside scattering media plays a key role in such biomedical applications as high resolution optical imaging, control, and therapy. In recent years, wavefront shaping technologies have come a long way in controlling light propagation in complex media. A prominent example is time-reversed ultrasonically encoded (TRUE) focusing, which allows noninvasive introduction of "guide stars" inside biological tissue to guide light focusing. By measuring the optical wavefront emanating from an ultrasound focus created at the target location, TRUE determines the desired wavefront non-iteratively, and achieves focusing at the target position via a subsequent optical time reversal. Compared to digital counterparts that employ slow electronic spatial light modulators and cameras, analog TRUE focusing relies on nonlinear photorefractive crystals that inherently accommodate more spatial modes and eliminate the troublesome alignment and data transfer required by digital approaches. However, analog TRUE focusing suffers from its small gain, defined as the energy or power ratio between the focusing and probing beams in the focal volume. Here, by implementing a modified analog TRUE focusing scheme that squeezes the duration of the time-reversed photon packet below the carrier-recombination-limited hologram decay time of the crystal, we demonstrated a photon flux amplification much greater than unity at a preset focal voxel in between two scattering layers. Although the energy gain was still below unity, the unprecedented power gain will nevertheless benefit new biomedical applications.

  15. General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats.

    Science.gov (United States)

    Swithers, Susan E; Baker, Chelsea R; Davidson, T L

    2009-08-01

    In an earlier work (S. E. Swithers & T. L. Davidson, 2008), rats provided with a fixed amount of a yogurt diet mixed with saccharin gained more weight and showed impaired caloric compensation relative to rats given the same amount of yogurt mixed with glucose. The present 4 experiments examined the generality of these findings and demonstrated that increased body weight gain was also demonstrated when animals consumed a yogurt diet sweetened with an alternative high-intensity sweetener (acesulfame potassium; AceK) as well as in animals given a saccharin-sweetened base diet (refried beans) that was calorically similar but nutritionally distinct from low-fat yogurt. These studies also extended earlier findings by showing that body weight differences persist after saccharin-sweetened diets are discontinued and following a shift to a diet sweetened with glucose. In addition, rats first exposed to a diet sweetened with glucose still gain additional weight when subsequently exposed to a saccharin-sweetened diet. The results of these experiments add support to the hypothesis that exposure to weak or nonpredictive relationships between sweet tastes and caloric consequences may lead to positive energy balance.

  16. Late effects of sleep restriction: Potentiating weight gain and insulin resistance arising from a high-fat diet in mice.

    Science.gov (United States)

    de Oliveira, Edson Mendes; Visniauskas, Bruna; Sandri, Silvana; Migliorini, Silene; Andersen, Monica Levy; Tufik, Sergio; Fock, Ricardo Ambrósio; Chagas, Jair Ribeiro; Campa, Ana

    2015-02-01

    Epidemiological studies show the association of sleep restriction (SR) with obesity and insulin resistance. Experimental studies are limited to the concurrent or short-term effects of SR. Here, we examined the late effects of SR regarding weight gain and metabolic alterations induced by a high-fat diet (HFD). C57BL/6 mice were subjected to a multiple platform method of SR for 15 days, 21 h daily, followed by 6 weeks of a 30% HFD. Just after SR, serum insulin and resistin concentrations were increased and glycerol content decreased. In addition, resistin, TNF-α, and IL-6 mRNA expression were notably increased in epididymal fat. At the end of the HFD period, mice previously submitted to SR gained more weight (32.3 ± 1.0 vs. 29.4 ± 0.7 g) with increased subcutaneous fat mass, had increments in the expression of the adipogenic genes PPARγ, C/EBPα, and C/EBPβ, and had macrophage infiltration in the epididymal adipose tissue. Furthermore, enhanced glucose tolerance and insulin resistance were also observed. The consequences of SR may last for a long period, characterizing SR as a predisposing factor for weight gain and insulin resistance. Metabolic changes during SR seem to prime adipose tissue, aggravating the harmful effects of diet-induced obesity. © 2014 The Obesity Society.

  17. Time Is Money: The Decision Making of Smartphone High Users in Gain and Loss Intertemporal Choice.

    Science.gov (United States)

    Tang, Zixuan; Zhang, Huijun; Yan, An; Qu, Chen

    2017-01-01

    Nowadays the smartphone plays an important role in our lives. While it brings us convenience and efficiency, its overuse can cause problems. Although a great number of studies have demonstrated that people affected by substance abuse, pathological gambling, and internet addiction disorder have lower self-control than average, scarcely any study has investigated the decision making of smartphone high users by using a behavioral paradigm. The present study employed an intertemporal task, the Smartphone Addiction Inventory (SPAI) and the Barratt Impulsiveness Scale 11th version (BIS-11) to explore the decision control of smartphone high users in a sample of 125 college students. Participants were divided into three groups according to their SPAI scores. The upper third (69 or higher), middle third (from 61 to 68) and lower third (60 or lower) of scores were defined as high smartphone users, medium users and low users, respectively. We compared the percentage of small immediate reward/penalty choices in different conditions between the three groups. Relative to the low users group, high users and medium users were more inclined to request an immediate monetary reward. Moreover, for the two dimensions of time and money in intertemporal choice, high users and medium users showed a bias in intertemporal choice task among most of the time points and value magnitude compared to low users. These findings demonstrated that smartphone overuse was associated with problematic decision-making, a pattern similar to that seen in persons affected by a variety of addictions.

  18. Time Is Money: The Decision Making of Smartphone High Users in Gain and Loss Intertemporal Choice

    Science.gov (United States)

    Tang, Zixuan; Zhang, Huijun; Yan, An; Qu, Chen

    2017-01-01

    Nowadays the smartphone plays an important role in our lives. While it brings us convenience and efficiency, its overuse can cause problems. Although a great number of studies have demonstrated that people affected by substance abuse, pathological gambling, and internet addiction disorder have lower self-control than average, scarcely any study has investigated the decision making of smartphone high users by using a behavioral paradigm. The present study employed an intertemporal task, the Smartphone Addiction Inventory (SPAI) and the Barratt Impulsiveness Scale 11th version (BIS-11) to explore the decision control of smartphone high users in a sample of 125 college students. Participants were divided into three groups according to their SPAI scores. The upper third (69 or higher), middle third (from 61 to 68) and lower third (60 or lower) of scores were defined as high smartphone users, medium users and low users, respectively. We compared the percentage of small immediate reward/penalty choices in different conditions between the three groups. Relative to the low users group, high users and medium users were more inclined to request an immediate monetary reward. Moreover, for the two dimensions of time and money in intertemporal choice, high users and medium users showed a bias in intertemporal choice task among most of the time points and value magnitude compared to low users. These findings demonstrated that smartphone overuse was associated with problematic decision-making, a pattern similar to that seen in persons affected by a variety of addictions. PMID:28344568

  19. Cortical activation changes underlying stimulation-induced behavioural gains in chronic stroke

    Science.gov (United States)

    Bachtiar, Velicia; O'Shea, Jacinta; Allman, Claire; Bosnell, Rosemary Ann; Kischka, Udo; Matthews, Paul McMahan; Johansen-Berg, Heidi

    2012-01-01

    Transcranial direct current stimulation, a form of non-invasive brain stimulation, is showing increasing promise as an adjunct therapy in rehabilitation following stroke. However, although significant behavioural improvements have been reported in proof-of-principle studies, the underlying mechanisms are poorly understood. The rationale for transcranial direct current stimulation as therapy for stroke is that therapeutic stimulation paradigms increase activity in ipsilesional motor cortical areas, but this has not previously been directly tested for conventional electrode placements. This study was performed to test directly whether increases in ipsilesional cortical activation with transcranial direct current stimulation are associated with behavioural improvements in chronic stroke patients. Patients at least 6 months post-first stroke participated in a behavioural experiment (n = 13) or a functional magnetic resonance imaging experiment (n = 11), each investigating the effects of three stimulation conditions in separate sessions: anodal stimulation to the ipsilesional hemisphere; cathodal stimulation to the contralesional hemisphere; and sham stimulation. Anodal (facilitatory) stimulation to the ipsilesional hemisphere led to significant improvements (5–10%) in response times with the affected hand in both experiments. This improvement was associated with an increase in movement-related cortical activity in the stimulated primary motor cortex and functionally interconnected regions. Cathodal (inhibitory) stimulation to the contralesional hemisphere led to a functional improvement only when compared with sham stimulation. We show for the first time that the significant behavioural improvements produced by anodal stimulation to the ipsilesional hemisphere are associated with a functionally relevant increase in activity within the ipsilesional primary motor cortex in patients with a wide range of disabilities following stroke. PMID:22155982

  20. Reduced sympathetic nervous activity. A potential mechanism predisposing to body weight gain.

    OpenAIRE

    Spraul, M; Ravussin, E; Fontvieille, A M; Rising, R; Larson, D. E.; Anderson, E A

    1993-01-01

    The sympathetic nervous system is recognized to play a role in the etiology of animal and possibly human obesity through its impact on energy expenditure and/or food intake. We, therefore, measured fasting muscle sympathetic nerve activity (MSNA) in the peroneal nerve and its relationship with energy expenditure and body composition in 25 relatively lean Pima Indian males (means +/- SD; 26 +/- 6 yr, 82 +/- 19 kg, 28 +/- 10% body fat) and 19 Caucasian males (29 +/- 5 yr, 81 +/- 13 kg, 24 +/- 9...

  1. Cortical activation changes underlying stimulation-induced behavioural gains in chronic stroke

    OpenAIRE

    Stagg, Charlotte Jane; Bachtiar, Velicia; O'Shea, Jacinta; Allman, Claire; Bosnell, Rosemary Ann; Kischka, Udo; Matthews, Paul McMahan; Johansen-Berg, Heidi

    2011-01-01

    Transcranial direct current stimulation, a form of non-invasive brain stimulation, is showing increasing promise as an adjunct therapy in rehabilitation following stroke. However, although significant behavioural improvements have been reported in proof-of-principle studies, the underlying mechanisms are poorly understood. The rationale for transcranial direct current stimulation as therapy for stroke is that therapeutic stimulation paradigms increase activity in ipsilesional motor cortical a...

  2. Cortical activation changes underlying stimulation-induced behavioural gains in chronic stroke.

    Science.gov (United States)

    Stagg, Charlotte Jane; Bachtiar, Velicia; O'Shea, Jacinta; Allman, Claire; Bosnell, Rosemary Ann; Kischka, Udo; Matthews, Paul McMahan; Johansen-Berg, Heidi

    2012-01-01

    Transcranial direct current stimulation, a form of non-invasive brain stimulation, is showing increasing promise as an adjunct therapy in rehabilitation following stroke. However, although significant behavioural improvements have been reported in proof-of-principle studies, the underlying mechanisms are poorly understood. The rationale for transcranial direct current stimulation as therapy for stroke is that therapeutic stimulation paradigms increase activity in ipsilesional motor cortical areas, but this has not previously been directly tested for conventional electrode placements. This study was performed to test directly whether increases in ipsilesional cortical activation with transcranial direct current stimulation are associated with behavioural improvements in chronic stroke patients. Patients at least 6 months post-first stroke participated in a behavioural experiment (n = 13) or a functional magnetic resonance imaging experiment (n = 11), each investigating the effects of three stimulation conditions in separate sessions: anodal stimulation to the ipsilesional hemisphere; cathodal stimulation to the contralesional hemisphere; and sham stimulation. Anodal (facilitatory) stimulation to the ipsilesional hemisphere led to significant improvements (5-10%) in response times with the affected hand in both experiments. This improvement was associated with an increase in movement-related cortical activity in the stimulated primary motor cortex and functionally interconnected regions. Cathodal (inhibitory) stimulation to the contralesional hemisphere led to a functional improvement only when compared with sham stimulation. We show for the first time that the significant behavioural improvements produced by anodal stimulation to the ipsilesional hemisphere are associated with a functionally relevant increase in activity within the ipsilesional primary motor cortex in patients with a wide range of disabilities following stroke.

  3. Fundamental Properties and Practical Application of Active Microwave Metamaterials Incorporating Gain Devices

    Science.gov (United States)

    2017-02-22

    person shall be subject to any penalty for failing to comply with a collection of information   if it does not display a currently valid OMB control... transmission line and an active volumetric metamaterial. These designs have been extended to THz frequency range. In addition, we have investigated the non...circuits,” IEEE International Microwave Symposium, Phoenix, Arizona, May 17-22, 2015. [7] Q. Tang, and H. Xin, “Stability of Tunnel Diode based Negative

  4. The Development of a Digital Marketing Strategy to Gain Active Mobile Game Users in Japan

    OpenAIRE

    Rönkkö, Makiyo

    2014-01-01

    Japan is the world’s biggest spender on mobile apps. This makes it an attractive market, but entering the Japan market is very difficult for Finnish mobile software developers. The goal of this thesis is to identify possible constraints that limit mobile game companies in the Japanese market, and analyze the means of increasing brand awareness and acquiring active game players. The focus is on finding the key elements required for building a digital marketing strategy targeted towards Japanes...

  5. Subthreshold Schottky-barrier thin-film transistors with ultralow power and high intrinsic gain

    Science.gov (United States)

    Lee, Sungsik; Nathan, Arokia

    2016-10-01

    The quest for low power becomes highly compelling in newly emerging application areas related to wearable devices in the Internet of Things. Here, we report on a Schottky-barrier indium-gallium-zinc-oxide thin-film transistor operating in the deep subthreshold regime (i.e., near the OFF state) at low supply voltages (400) that was both bias and geometry independent. The transistor reported here is useful for sensor interface circuits in wearable devices where high current sensitivity and ultralow power are vital for battery-less operation.

  6. Microwave control using a high-gain bias-free optoelectronic switch

    Science.gov (United States)

    Freeman, J. L.; Ray, S.; West, D. L.; Thompson, A. G.; Lagasse, M. J.

    1991-08-01

    We describe an optoelectronic microwave switch that exploits the high optical sensitivity of the air-GaAs interface. With an optical power of 100 micro-W, the switch has an insertion loss of 3.4 dB and an isolation of greater than 20 dB from 0 to 10 GHz. No electrical power is needed.

  7. Energy gain and spectral tailoring of ion beams using ultra-high intensity laser beams

    Science.gov (United States)

    Prasad, Rajendra; Swantusch, Marco; Cerchez, Mirela; Spickermann, Sven; Auorand, Bastian; Wowra, Thomas; Boeker, Juergen; Willi, Oswald

    2015-11-01

    The field of laser driven ion acceleration over the past decade has produced a huge amount of research. Nowadays, several multi-beam facilities with high rep rate system, e.g. ELI, are being developed across the world for different kinds of experiments. The study of interaction dynamics of multiple beams possessing ultra-high intensity and ultra-short pulse duration is of vital importance. Here, we present the first experimental results on ion acceleration using two ultra-high intensity beams. Thanks to the unique capability of Arcturus laser at HHU Düsseldorf, two almost identical, independent beams in laser parameters such as intensity (>1020 W/cm2), pulse duration (30 fs) and contrast (>1010), could be accessed. Both beams are focused onto a 5 μm thin Ti target. While ensuring spatial overlap of the two beams, at relative temporal delay of ~ 50 ps (optimum delay), the proton and carbon ion energies were enhanced by factor of 1.5. Moreover, strong modulation in C4+ions near the high energy cut-off is observed later than the optimum delay for the proton enhancement. This offers controlled tailoring of the spectral content of heavy ions.

  8. Geophysical Monitoring of Active Infiltration Experiments for Recharge Estimation: Gains and Pains

    Science.gov (United States)

    Noell, U.; Lamparter, A.; Houben, G.; Koeniger, P.; Stoeckl, L.; Guenther, T.

    2014-12-01

    Drinking water supply on the island of Langeoog, North Sea, solely depends on groundwater from a freshwater lens. The correct estimation of the recharge rate is critical for a sustainable use of the resource. Extensive hydrogeological and geophysical studies have revealed differences in groundwater recharge by a factor of two and more between the top of the dunes and the dune valleys. The most convincing proof of these differences in recharge is based on isotope analysis (age dating) but boreholes are scarce and a direct proof of recharge is desired. For this purpose active infiltration experiments are performed and geophysically monitored. Former applications of this method in sand and loess soil gave evidence for the applicability of the geophysical observation when combined with tensiometers installed in situ at depth. These results showed firstly that in sandy soil the water reaches the groundwater table quicker than anticipated due to the water repellent characteristic of the dry sand, inhibiting the lateral spreading of the water. The studies also revealed that in loess preferential flow is initiated by ponding and that sprinkling caused very slow movement of water within the unsaturated zone and the water remained near the surface. On the island of Langeoog field experiments underlined the importance of water repellency on the dune surface, indicating that the rain water runs off superficially into the dune valleys where higher recharge is found. The active infiltration zone of the experiment covers an area of some 7m² and includes steeper parts of the dune. The infiltration will vary depending on rainfall intensity and duration, original water content and vegetation cover. What results can we reliably expect from the active experiment and what additional measurements are required to back up the findings? Results are ambiguous with regard to the quantitative assessment but the processes can be visualized by geophysical monitoring in situ.

  9. Simplification of Sun Tracking Mode to Gain High Concentration Solar Energy

    Directory of Open Access Journals (Sweden)

    Omar Aliman

    2007-01-01

    Full Text Available Power conversion from solar thermal energy to electrical energy is still very cost-intensive. Serious effort has to be given in the development of the concentrator or heliostat structure expenditure which contributing the most expensive component in a central receiver solar power plant. With current development to find alternatives and lower down the capital, a new mode of sun tracking has been developed and feasibility tested. As it applies a single stage collector replacing conventional double stages structure, the new technique has significantly benefits use in high temperature and high concentration solar energy applications. Meanwhile, the stationary or fixed target (receiver offers more convenient working environment for various applications. Large and heavy solar powered Stirling Engine could be placed at the stationary location. On the other advantage offers by the new technique, the optical alignment was reasonably easier and less time consuming.

  10. Time Is Money: The Decision Making of Smartphone High Users in Gain and Loss Intertemporal Choice

    OpenAIRE

    Tang, Zixuan; Zhang, Huijun; Yan, An; Qu, Chen

    2017-01-01

    Nowadays the smartphone plays an important role in our lives. While it brings us convenience and efficiency, its overuse can cause problems. Although a great number of studies have demonstrated that people affected by substance abuse, pathological gambling, and internet addiction disorder have lower self-control than average, scarcely any study has investigated the decision making of smartphone high users by using a behavioral paradigm. The present study employed an intertemporal task, the Sm...

  11. Ultrahigh gain AlGaN/GaN high energy radiation detectors

    Energy Technology Data Exchange (ETDEWEB)

    Howgate, J.D.; Schoell, S.J.; Schaefer, S.; Stutzmann, M.; Sharp, I.D. [Walter Schottky Institut and Physik Department, Technische Universitaet Muenchen, Am Coulombwall 4, 85748 Garching (Germany); Hofstetter, M.; Schmid, M.; Thalhammer, S. [Helmholtz Zentrum Muenchen, Ingolstaedter Landstrasse 1, 85764 Neuherberg (Germany); Zizak, I. [Helmholtz Zentrum Berlin, Albert-Einstein-Str. 15, 12489 Berlin (Germany); Hable, V.; Greubel, C.; Dollinger, G. [Institut fuer Angewandte Physik und Messtechnik LRT2, Werner-Heisenberg-Weg 39, 85577 Neubiberg (Germany)

    2012-08-15

    Due to its remarkable tolerance to high energy ionizing radiation, GaN has recently attracted attention as a promising material for dosimetry applications. However, materials issues that lead to persistent photoconductivity, poor sensitivity, and requirements for large operational voltages have been hurdles to realization of the full potential of this material. Here we demonstrate that the introduction of a two-dimensional electron gas channel, through the addition of AlGaN/GaN heterointerfaces, can be used to create intrinsic amplification of the number of electrons that can be collected from single ionization events, yielding exceptionally large sensitivities in ultralow dose rate regimes. Furthermore, anomalous photo-responses, which severely limit response times of GaN-based devices, can be eliminated using these heterostructures. Measurements using focused monochromatic synchrotron radiation at 1-20 keV, as well as focused 20 MeV protons, reveal that these devices provide the capability for high sensitivity and resolution real time monitoring, which is competitive with and complementary to state-of-the-art detectors. Therefore, AlGaN/GaN heterostructure devices are extremely promising for future applications in fields ranging from high energy physics to medical imaging. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  12. Evaluation of Methionine Content in a High-Fat and Choline-Deficient Diet on Body Weight Gain and the Development of Non-Alcoholic Steatohepatitis in Mice.

    Science.gov (United States)

    Chiba, Tsuyoshi; Suzuki, Sachina; Sato, Yoko; Itoh, Tatsuki; Umegaki, Keizo

    2016-01-01

    Non-alcoholic steatohepatitis (NASH) is a globally recognized liver disease. A methionine- and choline-deficient diet is used to induce NASH in mice; however, this diet also causes severe body weight loss. To resolve this issue, we examined the effects of methionine content in a high-fat and choline-deficient (HFCD) diet on body weight and the development of NASH in mice. C57BL/6J mice (male, 10 weeks of age) were fed an L-amino acid rodent (control) diet, high-fat (HF) diet, or HFCD diet containing various amounts of methionine (0.1-0.6% (w/w)) for 12 weeks. Plasma lipid levels, hepatic lipid content and inflammatory marker gene expression were measured, and a pathological analysis was conducted to evaluate NASH. The 0.1% methionine in HFCD diet suppressed body weight gain, which was lower than that with control diet. On the other hand, the 0.2% methionine in HFCD diet yielded similar body weight gains as the control diet, while more than 0.4% methionine showed the same body weight gains as the HF diet. Liver weights and hepatic lipid contents were the greatest with 0.1% methionine and decreased in a methionine dose-dependent manner. Pathological analysis, NAFLD activity scores and gene expression levels in the liver revealed that 0.1% and 0.2% methionine for 12 weeks induced NASH, whereas 0.4% and 0.6% methionine attenuated the induction of NASH by HFCD diet. However, the 0.2% methionine in HFCD diet did not induce insulin resistance, despite the body weight gain. The 0.2% methionine in HFCD diet for 12 weeks was able to induce NASH without weight loss.

  13. High-gain adaptive regulator for a string equation with uncertain harmonic disturbance under boundary output feedback control

    Institute of Scientific and Technical Information of China (English)

    Baozhu GUO; Wei GUO

    2003-01-01

    This paper considers the boundary stabilization and parameter estimation of a one-dimensional wave equation in the case when one end is fixed and control and harmonic disturbance with uncertain amplitude are input at another end. A high-gain adaptive regulator is designed in terms of measured collocated end velocity. The existence and uniqueness of the classical solution of the closed-loop system is proven. It is shown that the state of the system approaches the standstill as time goes to infitv and meanwhile, the estimated parameter converges to the unknown parameter.

  14. Transverse and temporal characteristics of a high-gain free-electron laser in the saturation regime

    CERN Document Server

    Huang Zhi Rong

    2002-01-01

    The transverse and the temporal characteristics of a high-gain free-electron laser are governed by refractive guiding and sideband instability, respectively. Using the self-consistent Vlasov-Maxwell equations, we explicitly determine the effective index of refraction and the guided radiation mode for an electron beam with arbitrary transverse size. Electrons trapped by the guided radiation execute synchrotron oscillation and hence are susceptible to the sideband instability. We explain the spectral evolution and determine the sideband growth rate. These theoretical predictions agree well with GINGER simulation results.

  15. Results of innovative communication processes on productivity gains in a high technology environment

    Science.gov (United States)

    Kelly, B. J.

    1985-01-01

    The technology which resulted in performance breakthroughs at engineering and management services is discussed. As a result of the innovative approaches of communicating productivity concepts to the employees, specific outcomes can now be pinpointed at all levels of the organization such as: (1) employee-headed program; (2) performance feedback processes; and (3) an investigative approach to creating leadership. The Lockheed Corporation began the innovative trend in 1974 when they became the first company to introduce quality circles in America. Although some of Lockheed-EMSCO's processes may sound different from traditional improvement processes, the context out of which those to be presented evolved has sustained more than 10 years of positive results through employee involvement activities.

  16. Novel Interleaved Converter with Extra-High Voltage Gain to Process Low-Voltage Renewable-Energy Generation

    Directory of Open Access Journals (Sweden)

    Chih-Lung Shen

    2016-10-01

    Full Text Available This paper presents a novel interleaved converter (NIC with extra-high voltage gain to process the power of low-voltage renewable-energy generators such as photovoltaic (PV panel, wind turbine, and fuel cells. The NIC can boost a low input voltage to a much higher voltage level to inject renewable energy to DC bus for grid applications. Since the NIC has two circuit branches in parallel at frond end to share input current, it is suitable for high power applications. In addition, the NIC is controlled in an interleaving pattern, which has the advantages that the NIC has lower input current ripple, and the frequency of the ripple is twice the switching frequency. Two coupled inductors and two switched capacitors are incorporated to achieve a much higher voltage gain than conventional high step-up converters. The proposed NIC has intrinsic features such as leakage energy totally recycling and low voltage stress on power semiconductor. Thorough theoretical analysis and key parameter design are presented in this paper. A prototype is built for practical measurements to validate the proposed NIC.

  17. Yield gains of coffee plants from phosphorus fertilization may not be generalized for high density planting

    Directory of Open Access Journals (Sweden)

    Samuel Vasconcelos Valadares

    2014-06-01

    Full Text Available Inconclusive responses of the adult coffee plant to phosphorus fertilization have been reported in the literature, especially when dealing with application of this nutrient in high density planting systems. Thus, this study was carried out for the purpose of assessing the response of adult coffee plants at high planting density in full production (in regard to yield and their biennial cycle/stability to the addition of different sources and application rates of P in the Zona da Mata region of Minas Gerais, Brazil. The experiment with coffee plants of the Catucaí Amarelo 6/30 variety was carried out over four growing seasons. Treatments were arranged in a full factorial design [(4 × 3 + 1] consisting of four P sources (monoammonium phosphate, simple superphosphate, natural reactive rock phosphate from Algeria (Djebel-Onk, and FH 550®, three P rates (100, 200, and 400 kg ha-1 year-1 of P2O5, and an additional treatment without application of the nutrient (0 kg ha-¹ year-¹. A randomized block experimental design was used with three replicates. The four seasons were evaluated as subplots in a split plot experiment. The P contents in soil and leaves increased with increased rates of P application. However, there was no effect from P application on the yield and its biennial cycle/stability regardless of the source used over the four seasons assessed.

  18. Levamisole: A positive allosteric modulator for the α3β4 nicotinic acetylcholine receptors prevents weight gain in CD-1 mice on a high fat diet.

    Science.gov (United States)

    Lewis, Jeanne A; Yakel, Jerrel L; Pandya, Anshul A

    2016-12-01

    Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the function of multiple neurotransmitter pathways throughout the central nervous system. This includes nAChRs found on the proopiomelanocortin neurons in the hypothalamus. Activation of these nAChRs by nicotine causes a decrease in consumption of food in rodents. In this study, we tested the effect of subtype selective allosteric modulators for nAChRs on the body weight of CD-1 mice. Levamisole, an allosteric modulator for the α3β4 subtype of nAChRs, prevented weight gain in mice that were fed a high fat diet. PNU-120596 and desformylflustrabromine are selective PAMs for the α7 and α4β2 nAChR, respectively. Both of these compounds failed to prevent weight gain in CD-1 mice. These results suggest that modulation of hypothalamic α3β4 nAChRs is an important factor in regulating food intake, and the PAMs for these receptors need further investigation as potential therapeutic agents for controlling weight gain.

  19. A High-Gain Passive UHF-RFID Tag with Increased Read Range

    Science.gov (United States)

    Zuffanelli, Simone; Aguila, Pau; Zamora, Gerard; Paredes, Ferran; Martin, Ferran; Bonache, Jordi

    2016-01-01

    In this work, a passive ultra-high frequency radio-frequency identification UHF-RFID tag based on a 1.25 wavelengths thin dipole antenna is presented for the first time. The length of the antenna is properly chosen in order to maximize the tag read range, while maintaining a reasonable tag size and radiation pattern. The antenna is matched to the RFID chip by means of a very simple matching network based on a shunt inductance. A tag prototype, based on the Alien Higgs-3 chip, is designed and fabricated. The overall dimensions are 400 mm × 14.6 mm, but the tag width for most of its length is delimited by the wire diameter (0.8 mm). The measured read range exhibits a maximum value of 17.5 m at the 902–928 MHz frequency band. This represents an important improvement over state-of-the-art passive UHF-RFID tags. PMID:27455274

  20. A High-Gain Passive UHF-RFID Tag with Increased Read Range

    Directory of Open Access Journals (Sweden)

    Simone Zuffanelli

    2016-07-01

    Full Text Available In this work, a passive ultra-high frequency radio-frequency identification UHF-RFID tag based on a 1.25 wavelengths thin dipole antenna is presented for the first time. The length of the antenna is properly chosen in order to maximize the tag read range, while maintaining a reasonable tag size and radiation pattern. The antenna is matched to the RFID chip by means of a very simple matching network based on a shunt inductance. A tag prototype, based on the Alien Higgs-3 chip, is designed and fabricated. The overall dimensions are 400 mm × 14.6 mm, but the tag width for most of its length is delimited by the wire diameter (0.8 mm. The measured read range exhibits a maximum value of 17.5 m at the 902–928 MHz frequency band. This represents an important improvement over state-of-the-art passive UHF-RFID tags.

  1. Semi-global robust output regulation of minimum-phase nonlinear systems based on high-gain nonlinear internal model

    Science.gov (United States)

    Wei, Xile; Lu, Meili; Wang, Jiang; Tsang, K. M.; Deng, Bin; Che, Yanqiu

    2010-05-01

    We consider the assumption of existence of the general nonlinear internal model that is introduced in the design of robust output regulators for a class of minimum-phase nonlinear systems with rth degree (r ≥ 2). The robust output regulation problem can be converted into a robust stabilisation problem of an augmented system consisting of the given plant and a high-gain nonlinear internal model, perfectly reproducing the bounded including not only periodic but also nonperiodic exogenous signal from a nonlinear system, which satisfies some general immersion assumption. The state feedback controller is designed to guarantee the asymptotic convergence of system errors to zero manifold. Furthermore, the proposed scheme makes use of output feedback dynamic controller that only processes information from the regulated output error by using high-gain observer to robustly estimate the derivatives of the regulated output error. The stabilisation analysis of the resulting closed-loop systems leads to regional as well as semi-global robust output regulation achieved for some appointed initial condition in the state space, for all possible values of the uncertain parameter vector and the exogenous signal, ranging over an arbitrary compact set.

  2. Performance of a Combined System Using an X-Ray FEL Oscillator and a High-Gain FEL Amplifier

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, L.; Lindberg, R.; Kim, K. -J.

    2016-10-01

    The LCLS-II at SLAC will feature a 4 GeV CW superconducting (SC) RF linac [1] that can potentially drive a 5th harmonic X-Ray FEL Oscillator (XFELO) to produce fully coherent, 1 MW photon pulses with a 5 meV bandwidth at 14.4 keV [2]. The XFELO output can serve as the input seed signal for a high-gain FEL amplifier employing fs electron beams from the normal conducting SLAC linac, thereby generating coherent, fs x-ray pulses with TW peak powers using a tapered undulator after saturation [3]. Coherent, intense output at several tens of keV will also be feasible if one considers a harmonic generation scheme. Thus, one can potentially reach the 42 keV photon energy required for the MaRIE project [4] by beginning with an XFELO operating at the 3rd harmonic to produce 14.0 keV photons using a 12 GeV SCRF linac, and then subsequently using the high-gain harmonic generation scheme to generate and amplify the 3th harmonic at 42 keV [5]. We report extensive GINGER simulations that determine an optimized parameter set for the combined system.

  3. Sensitivity gains, linearity, and spectral reproducibility in nonuniformly sampled multidimensional MAS NMR spectra of high dynamic range

    Science.gov (United States)

    Suiter, Christopher L.; Paramasivam, Sivakumar; Hou, Guangjin; Sun, Shangjin; Rice, David; Hoch, Jeffrey C.; Rovnyak, David

    2014-01-01

    Recently, we have demonstrated that considerable inherent sensitivity gains are attained in MAS NMR spectra acquired by nonuniform sampling (NUS) and introduced maximum entropy interpolation (MINT) processing that assures the linearity of transformation between the time and frequency domains. In this report, we examine the utility of the NUS/MINT approach in multidimensional datasets possessing high dynamic range, such as homonuclear 13C–13C correlation spectra. We demonstrate on model compounds and on 1–73-(U-13C, 15N)/74–108-(U-15N) E. coli thioredoxin reassembly, that with appropriately constructed 50 % NUS schedules inherent sensitivity gains of 1.7–2.1-fold are readily reached in such datasets. We show that both linearity and line width are retained under these experimental conditions throughout the entire dynamic range of the signals. Furthermore, we demonstrate that the reproducibility of the peak intensities is excellent in the NUS/MINT approach when experiments are repeated multiple times and identical experimental and processing conditions are employed. Finally, we discuss the principles for design and implementation of random exponentially biased NUS sampling schedules for homonuclear 13C–13C MAS correlation experiments that yield high-quality artifact-free datasets. PMID:24752819

  4. Sensitivity Gains, Linearity, and Spectral Reproducibility in Nonuniformly Sampled Multidimensional MAS NMR Spectra of High Dynamic Range.

    Energy Technology Data Exchange (ETDEWEB)

    Suiter, Christopher L.; Paramasivam, Sivakumar; Hou, Guangjin; Sun, Shangjin; Rice, David M.; Hoch, Jeffrey C.; Rovnyak, David S.; Polenova, Tatyana E.

    2014-04-22

    Recently, we have demonstrated that considerable inherent sensitivity gains are attained in MAS NMR spectra acquired by nonuniform sampling (NUS) and introduced maximum entropy interpolation (MINT) processing that assures the linearity of transformation between the time and frequency domains. In this report, we examine the utility of the NUS/MINT approach in multidimensional datasets possessing high dynamic range, such as homonuclear 13C–13C correlation spectra. We demonstrate on model compounds and on 1–73-(U-13C,15N)/74–108-(U-15N) E. coli thioredoxin reassembly, that with appropriately constructed 50 % NUS schedules inherent sensitivity gains of 1.7–2.1-fold are readily reached in such datasets. We show that both linearity and line width are retained under these experimental conditions throughout the entire dynamic range of the signals. Furthermore, we demonstrate that the reproducibility of the peak intensities is excellent in the NUS/MINT approach when experiments are repeated multiple times and identical experimental and processing conditions are employed. Finally, we discuss the principles for design and implementation of random exponentially biased NUS sampling schedules for homonuclear 13C–13C MAS correlation experiments that yield high quality artifact-free datasets.

  5. Gain control of gamma frequency activation by a novel feed forward disinhibitory loop: implications for normal and epileptic neural activity

    Directory of Open Access Journals (Sweden)

    Zeinab eBirjandian

    2013-11-01

    Full Text Available The inhibition of excitatory (pyramidal neurons directly dampens their activity resulting in a suppression of neural network output. The inhibition of inhibitory cells is more complex. Inhibitory drive is known to gate neural network synchrony, but there is also a widely held view that it may augment excitability by reducing inhibitory cell activity, a process termed disinhibition. Surprisingly, however, disinhibition has never been demonstrated to be an important mechanism that augments or drives the activity of excitatory neurons in a functioning neural circuit. Using voltage sensitive dye imaging (VSDI we show that 20-80 Hz stimulus trains, (beta-gamma activation, of the olfactory cortex pyramidal cells in layer II leads to a subsequent reduction in inhibitory interneuron activity that augments the efficacy of the initial stimulus. This disinhibition occurs with a lag of about 150-250 ms after the initial excitation of the layer 2 pyramidal cell layer. In addition activation of the endopiriform nucleus also arises just before the disinhibitory phase with a lag of about 40-80 ms. Preventing the spread of action potentials from layer II stopped the excitation of the endopiriform nucleus, abolished the disinhibitory activity and reduced the excitation of layer II cells. After the induction of experimental epilepsy the disinhibition was more intense with a concomitant increase in excitatory cell activity. Our observations provide the first evidence of feed forward disinhibition loop that augments excitatory neurotransmission, a mechanism that could play an important role in the development of epileptic seizures.

  6. Caffeine prevents weight gain and cognitive impairment caused by a high-fat diet while elevating hippocampal BDNF.

    Science.gov (United States)

    Moy, Gregory A; McNay, Ewan C

    2013-01-17

    Obesity, high-fat diets, and subsequent type 2 diabetes (T2DM) are associated with cognitive impairment. Moreover, T2DM increases the risk of Alzheimer's disease (AD) and leads to abnormal elevation of brain beta-amyloid levels, one of the hallmarks of AD. The psychoactive alkaloid caffeine has been shown to have therapeutic potential in AD but the central impact of caffeine has not been well-studied in the context of a high-fat diet. Here we investigated the impact of caffeine administration on metabolism and cognitive performance, both in control rats and in rats placed on a high-fat diet. The effects of caffeine were significant: caffeine both (i) prevented the weight-gain associated with the high-fat diet and (ii) prevented cognitive impairment. Caffeine did not alter hippocampal metabolism or insulin signaling, likely because the high-fat-fed animals did not develop full-blown diabetes; however, caffeine did prevent or reverse a decrease in hippocampal brain-derived neurotrophic factor (BDNF) seen in high-fat-fed animals. These data confirm that caffeine may serve as a neuroprotective agent against cognitive impairment caused by obesity and/or a high-fat diet. Increased hippocampal BDNF following caffeine administration could explain, at least in part, the effects of caffeine on cognition and metabolism.

  7. [Influence of maternal nutritional status, weight gain and energy intake on fetal growth in high-risk pregnancies].

    Science.gov (United States)

    Nomura, Roseli Mieko Yamamoto; Paiva, Letícia Vieira; Costa, Verbênia Nunes; Liao, Adolfo Wenjaw; Zugaib, Marcelo

    2012-03-01

    To analyze the influence of maternal nutritional status, weight gain and energy consumption on fetal growth in high-risk pregnancies. A prospective study from August 2009 to August 2010 with the following inclusion criteria: puerperae up to the 5th postpartum day; high-risk singleton pregnancies (characterized by medical or obstetrical complications during pregnancy); live fetus at labor onset; delivery at the institution; maternal weight measured on the day of delivery, and presence of medical and/or obstetrical complications characterizing pregnancy as high-risk. Nutritional status was assessed by pregestational body mass index and body mass index in late pregnancy, and the patients were classified as: underweight, adequate, overweight and obese. A food frequency questionnaire was applied to evaluate energy consumption. We investigated maternal weight gain, delivery data and perinatal outcomes, as well as fetal growth based on the occurrence of small for gestational age and large for gestational age neonates. We included 374 women who were divided into three study groups according to newborn birth weight: adequate for gestational age (270 cases, 72.2%), small for gestational age (91 cases, 24.3%), and large for gestational age (13 cases, 3.5%). Univaried analysis showed that women with small for gestational age neonates had a significantly lower mean pregestational body mass index (23.5 kg/m², ppregnancy (27.7 kg/m², ppregnancy (25.3%, ppregnancy (34.3 kg/m², ppregnancy (53.8%, ppregnancy (OR=0.9; CI95% 0.8-0.9, ppregnancy (OR=3.6; 95%CI 1.1-11.7, p=0.04). The maternal nutritional status at the end of pregnancy in high-risk pregnancies is independently associated with fetal growth, the body mass index during late pregnancy is a protective factor against small for gestational age neonates, and maternal obesity is a risk factor for large for gestational age neonates.

  8. Laser propagation through full-scale, high-gain MagLIF gas pipes using the NIF

    Science.gov (United States)

    Pollock, Bradley; Sefkow, Adam; Goyon, Clement; Strozzi, David; Khan, Shahab; Rosen, Mordy; Campbell, Mike; Logan, Grant; Peterson, Kyle; Moody, John

    2016-10-01

    The first relevant measurements of laser propagation through surrogate high-gain MagLIF gas pipe targets at full scale have been performed at the NIF, using 30 kJ of laser drive from one quad in a 10 ns pulse at an intensity of 2e14 W/cm2. The unmagnetized pipe is filled with 1 atm of 99%/1% neopentane/Ar, and uses an entrance window of 0.75 um polyimide and an exit window of 0.3 um of Ta backed with 5 um of polyimide. Side-on x-ray emission from the plasma is imaged through the 100 um-thick epoxy wall onto a framing camera at four times during the drive, and is in excellent agreement with pre-shot HYDRA radiation-hydrodynamics modeling. X-ray emission from the Ta exit plane is imaged onto a streak camera to determine the timing and intensity of the laser burning through the pipe, and the Ar emission from the center of the pipe is spectrally- and temporally-resolved to determine the plasma electron temperature. Backscatter is measured throughout the laser drive, and is found to be of significance only when the laser reaches the Ta exit plane and produces SBS. These first results in unmagnetized surrogate gas fills are encouraging since they demonstrate sufficient laser energy absorption and low LPI losses within high-density long-scale-length plasmas for proposed high-gain MagLIF target designs. We will discuss plans to magnetize targets filled with high-density DT gas in future experiments. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the National Nuclear Security Administration under Contract No. DE-AC04-94AL85000.

  9. On high-speed cross-gain modulation without pattern effects in quantum dot semiconductor optical amplifiers

    DEFF Research Database (Denmark)

    Uskov, A.V.; Mørk, Jesper; Tromborg, Bjarne

    2003-01-01

    In the regime with maximum linear gain in a quantum dot (QD) semiconductor optical amplifier (SOA), instantaneous gain modulation by change of the photon density is possible due to spectral hole burning effects. This, in turn, leads to the opportunity of ultrafast cross-gain modulation (XGM...

  10. Gain-of-function Lyn induces anemia: appropriate Lyn activity is essential for normal erythropoiesis and Epo receptor signaling.

    Science.gov (United States)

    Slavova-Azmanova, Neli S; Kucera, Nicole; Satiaputra, Jiulia; Stone, Leah; Magno, Aaron; Maxwell, Mhairi J; Quilici, Cathy; Erber, Wendy; Klinken, S Peter; Hibbs, Margaret L; Ingley, Evan

    2013-07-11

    Lyn is involved in erythropoietin (Epo)-receptor signaling and erythroid homeostasis. Downstream pathways influenced following Lyn activation and their significance to erythropoiesis remain unclear. To address this, we assessed a gain-of-function Lyn mutation (Lyn(up/up)) on erythropoiesis and Epo receptor signaling. Adult Lyn(up/up) mice were anemic, with dysmorphic red cells (spherocyte-like, acanthocytes) in their circulation, indicative of hemolytic anemia and resembling the human disorder chorea acanthocytosis. Heterozygous Lyn(+/up) mice became increasingly anemic with age, indicating that the mutation was dominant. In an attempt to overcome this anemia, extramedullary erythropoiesis was activated. As the mice aged, the levels of different immature erythroid populations changed, indicating compensatory mechanisms to produce more erythrocytes were dynamic. Changes in Epo signaling were observed in Lyn(+/up) erythroid cell lines and primary CD71(+) Lyn(up/up) erythroblasts, including significant alterations to the phosphorylation of Lyn, the Epo receptor, Janus kinase 2, Signal Transducer and Action of Transcription-5, GRB2-associated-binding protein-2, Akt, and Forkhead box O3. As a consequence of altered Lyn signaling, Lyn(+/up) cells remained viable in the absence of Epo but displayed delayed Epo-induced differentiation. These data demonstrate that Lyn gene dosage and activity are critical for normal erythropoiesis; constitutively active Lyn alters Epo signaling, which in turn produces erythroid defects.

  11. [ICF and social medicine evaluation of capability of gainful activity: is everything clear?--a discussion article].

    Science.gov (United States)

    Körner, M

    2005-08-01

    The ICF (International Classification of Functioning, Disability and Health) calls attention to the complexities associated with disturbances of health. The question raised is how the various constituents and the resulting network as defined by this Classification can gain importance for medical expertise under the statutory pension insurance scheme concerning work-related capacity. Possible variations of strategy are discussed: clinical intuition, algorithmic pathways, proved medical diagnostics, particular diagnostics of activity according to ICF. A genuine "silver bullet" is not in evidence thus far. It cannot be expected that diagnostics relating to a certain sector of the ICF will basically eclipse the rest. Future standards of medical expertise should specify as clearly as possible the impact of the diverse diagnostic findings on the assessment of work-related capacity. Framing emphasis in this way cannot be performed by the ICF on its own.

  12. Spectral Analysis of Quantum-Dash Lasers: Effect of Inhomogeneous Broadening of the Active-Gain Region

    KAUST Repository

    Khan, Mohammed Zahed Mustafa

    2012-05-01

    The effect of the active region inhomogeneity on the spectral characteristics of InAs/InP quantum-dash (Qdash) lasers is examined theoretically by solving the coupled set of carrier-photon rate equations. The inhomogeneity due to dash size or composition fluctuation is included in the model by considering dispersive energy states and characterized by a Gaussian envelope. In addition, the technique incorporates multilongitudinal photon modes and homogeneous broadening of the optical gain. The results predict a red shift in the central lasing wavelength of Qdash lasers on increasing the inhomogeneous broadening either explicitly or implicitly, which supports various experimental observations. The threshold current density and the lasing bandwidth are also found to increase. © 2012 IEEE.

  13. A new design methodology of obtaining wide band high gain broadband parametric source for infrared wavelength applications

    Science.gov (United States)

    Maji, Partha Sona; Roy Chaudhuri, Partha

    2016-03-01

    In this article, we have presented a new design methodology of obtaining wide band parametric sources based on highly nonlinear chalcogenide material of As2S3. The dispersion profile of the photonic crystal fiber (PCF) has been engineered wisely by reducing the diameter of the second air-hole ring to have a favorable higher order dispersion parameter. The parametric gain dependence upon fiber length, pump power, and different pumping wavelengths has been investigated in detail. Based upon the nonlinear four wave mixing phenomenon, we are able to achieve a wideband parametric amplifier with peak gain of 29 dB with FWHM of ≈2000 nm around the IR wavelength by proper tailoring of the dispersion profile of the PCF with a continuous wave Erbium (Er3+)-doped ZBLAN fiber laser emitting at 2.8 μm as the pump source with an average power of 5 W. The new design methodology will unleash a new dimension to the chalcogenide material based investigation for wavelength translation around IR wavelength band.

  14. College expectations in high school mitigate weight gain over early adulthood: Findings from a national study of American youth.

    Science.gov (United States)

    Clarke, Philippa J; O'Malley, Patrick M; Schulenberg, John E; Lee, Hedwig; Colabianchi, Natalie; Johnston, Lloyd D

    2013-07-01

    Research conducted on school-based interventions suggests that school connectedness protects against a variety of risk behaviors, including substance abuse, delinquency and sedentary behavior. The line of research is extended by examining the link between college expectations and early adult weight gain using nationally representative panel data from thirty cohorts of American high school seniors followed prospectively to age 30 in the Monitoring the Future Study (1986-2009). Growth mixture models identified two latent classes of trajectories of body mass index (BMI) from age 19 to 30: a persistently overweight class (BMI ≥ 25) and a second class exhibiting more moderate growth in BMI to age 30. Compared to those who did not expect to graduate from college, students fully expecting to graduate from college had 34% lower odds of being in the persistently overweight class (adjusted odds ratio = 0.66, 95% confidence interval = 0.54, 0.81), controlling for academic performance and socioeconomic status. Successful prevention of obesity early in the life course is based on a multifactorial approach incorporating strategies that address the contexts in which adolescents are embedded. The school setting may be one avenue where successful educational attachment could have positive consequences for subsequent weight gain in early adulthood. Copyright © 2012 The Obesity Society.

  15. A new design methodology of obtaining wide band high gain broadband parametric source for infrared wavelength applications

    Energy Technology Data Exchange (ETDEWEB)

    Maji, Partha Sona; Roy Chaudhuri, Partha [Department of Physics, Indian Institute of Technology, Kharagpur 721302 (India)

    2016-03-21

    In this article, we have presented a new design methodology of obtaining wide band parametric sources based on highly nonlinear chalcogenide material of As{sub 2}S{sub 3}. The dispersion profile of the photonic crystal fiber (PCF) has been engineered wisely by reducing the diameter of the second air-hole ring to have a favorable higher order dispersion parameter. The parametric gain dependence upon fiber length, pump power, and different pumping wavelengths has been investigated in detail. Based upon the nonlinear four wave mixing phenomenon, we are able to achieve a wideband parametric amplifier with peak gain of 29 dB with FWHM of ≈2000 nm around the IR wavelength by proper tailoring of the dispersion profile of the PCF with a continuous wave Erbium (Er{sup 3+})-doped ZBLAN fiber laser emitting at 2.8 μm as the pump source with an average power of 5 W. The new design methodology will unleash a new dimension to the chalcogenide material based investigation for wavelength translation around IR wavelength band.

  16. The effects of acute stress exposure on striatal activity during Pavlovian conditioning with monetary gains and losses.

    Science.gov (United States)

    Lewis, Andrea H; Porcelli, Anthony J; Delgado, Mauricio R

    2014-01-01

    Pavlovian conditioning involves the association of an inherently neutral stimulus with an appetitive or aversive outcome, such that the neutral stimulus itself acquires reinforcing properties. Across species, this type of learning has been shown to involve subcortical brain regions such as the striatum and the amygdala. It is less clear, however, how the neural circuitry involved in the acquisition of Pavlovian contingencies in humans, particularly in the striatum, is affected by acute stress. In the current study, we investigate the effect of acute stress exposure on Pavlovian conditioning using monetary reinforcers. Participants underwent a partial reinforcement conditioning procedure in which neutral stimuli were paired with high and low magnitude monetary gains and losses. A between-subjects design was used, such that half of the participants were exposed to cold stress while the remaining participants were exposed to a no stress control procedure. Cortisol measurements and subjective ratings were used as measures of stress. We observed an interaction between stress, valence, and magnitude in the ventral striatum, with the peak in the putamen. More specifically, the stress group exhibited an increased sensitivity to magnitude in the gain domain. This effect was driven by those participants who experienced a larger increase in circulating cortisol levels in response to the stress manipulation. Taken together, these results suggest that acute stress can lead to individual differences in circulating cortisol levels which influence the striatum during Pavlovian conditioning with monetary reinforcers.

  17. Gimbals Drive and Control Electronics Design, Development and Testing of the LRO High Gain Antenna and Solar Array Systems

    Science.gov (United States)

    Chernyakov, Boris; Thakore, Kamal

    2010-01-01

    Launched June 18, 2009 on an Atlas V rocket, NASA's Lunar Reconnaissance Orbiter (LRO) is the first step in NASA's Vision for Space Exploration program and for a human return to the Moon. The spacecraft (SC) carries a wide variety of scientific instruments and provides an extraordinary opportunity to study the lunar landscape at resolutions and over time scales never achieved before. The spacecraft systems are designed to enable achievement of LRO's mission requirements. To that end, LRO's mechanical system employed two two-axis gimbal assemblies used to drive the deployment and articulation of the Solar Array System (SAS) and the High Gain Antenna System (HGAS). This paper describes the design, development, integration, and testing of Gimbal Control Electronics (GCE) and Actuators for both the HGAS and SAS systems, as well as flight testing during the on-orbit commissioning phase and lessons learned.

  18. Modeling and output tracking of transverse flux permanent magnet machines using high gain observer and RBF neural network.

    Science.gov (United States)

    Karimi, H R; Babazadeh, A

    2005-10-01

    This paper deals with modeling and adaptive output tracking of a transverse flux permanent magnet machine as a nonlinear system with unknown nonlinearities by utilizing high gain observer and radial basis function networks. The proposed model is developed based on computing the permeance between rotor and stator using quasiflux tubes. Based on this model, the techniques of feedback linearization and Hinfinity control are used to design an adaptive control law for compensating the unknown nonlinear parts, such as the effect of cogging torque, as a disturbance is decreased onto the rotor angle and angular velocity tracking performances. Finally, the capability of the proposed method in tracking both the angle and the angular velocity is shown in the simulation results.

  19. Parameter Analysis For A High-Gain Harmonic Generation FEL By Numerical Calculation Based On 1D Theory

    CERN Document Server

    Li, Yuhui; Zhang, Shancai

    2004-01-01

    The high-gain harmonic generation (HGHG) free-electron laser (FEL) is an important candidate for a fourth-generation light source. Lots of theoretical work has been performed. Recently a further 1D theory about HGHG FEL has been developed. It considers the effects of different parameters for the whole process. An initial program based on this theory has been made. In this paper, a brief comparison of the results from this 1D program and from TDA (3D code) is discussed. It also analyses the parameters for Shanghai deep ultra violate free-electron laser source (SDUV-FEL), including electron beam energy spread, seed laser power, strength of dispersion section etc.

  20. Broadband and high-speed swept external-cavity laser using a quantum-dot superluminescent diode as gain device

    Science.gov (United States)

    Hu, Fa-Jie; Jin, Peng; Wu, Yan-Hua; Wang, Fei-Fei; Wei, Heng; Wang, Zhan-Guo

    2015-10-01

    A wide wavelength tuning range swept external-cavity laser using an InAs/GaAs quantum-dot superluminescent diode as a gain device is demonstrated. The tunable filter consists of a polygon scanner and a grating in Littrow telescope-less configuration. The swept laser generates greater than 54-mW peak output power and up to 33-kHz sweep rate with a sweep range of 150 nm centered at 1155 nm. The effects of injection current and sweep rate on the sweep performance of the swept laser are studied. Project supported by the National Natural Science Foundation of China (Grant No. 61274072) and the National High Technology Research and Development Program of China (Grant No. 2013AA014201).

  1. Transmission Enhancement of High-$k$ Waves through Metal-InGaAsP Multilayers Calculated via Scattering Matrix Method with Semi-Classical Optical Gain

    CERN Document Server

    Smalley, Joseph S T; Shahin, Shiva; Kanté, Boubacar; Fainman, Yeshaiahu

    2015-01-01

    We analyze the steady-state transmission of high-momentum (high-$k$) electromagnetic waves through metal-semiconductor multilayer systems with loss and gain in the near-infrared (NIR). Using a semi-classical optical gain model in conjunction with the scattering matrix method (SMM), we study indium gallium arsenide phosphide (InGaAsP) quantum wells as the active semiconductor, in combination with the metals, aluminum-doped zinc oxide (AZO) and silver (Ag). Under moderate external pumping levels, we find that NIR transmission through Ag/InGaAsP systems may be enhanced by several orders of magnitude relative to the unpumped case, over a large angular and frequency bandwidth. Conversely, transmission enhancement through AZO/InGaAsP systems is orders of magnitude smaller, and has a strong frequency dependence. We discuss the relative importance of Purcell enhancement on our results and validate analytical calculations based on the SMM with numerical finite-difference time domain simulations.

  2. High-resolution, on-chip RF photonic signal processor using Brillouin gain shaping and RF interference.

    Science.gov (United States)

    Choudhary, Amol; Liu, Yang; Morrison, Blair; Vu, Khu; Choi, Duk-Yong; Ma, Pan; Madden, Stephen; Marpaung, David; Eggleton, Benjamin J

    2017-07-19

    Integrated microwave photonics has strongly emerged as a next-generation technology to address limitations of conventional RF electronics for wireless communications. High-resolution RF signal processing still remains a challenge due to limitations in technology that offer sub-GHz spectral resolution, in particular at high carrier frequencies. In this paper, we present an on-chip high-resolution RF signal processor, capable of providing high-suppression spectral filtering, large phase shifts and ns-scale time delays. This was achieved through tailoring of the Brillouin gain profiles using Stokes and anti-Stokes resonances combined with RF interferometry on a low-loss photonic chip with strong opto-acoustic interactions. Using an optical power of RF signals we demonstrate, almost an order of magnitude amplification in the phase and delay compared to devices purely based upon the slow-light effect of Brillouin scattering. This concept allows for versatile and power-efficient manipulation of the amplitude and phase of RF signals on a photonic chip for applications in wireless communications including software defined radios and beam forming.

  3. A PMT-like high gain avalanche photodiode based on GaN/AlN periodically stacked structure

    Science.gov (United States)

    Zheng, Jiyuan; Wang, Lai; Wu, Xingzhao; Hao, Zhibiao; Sun, Changzheng; Xiong, Bing; Luo, Yi; Han, Yanjun; Wang, Jian; Li, Hongtao; Brault, Julien; Matta, Samuel; Khalfioui, Mohamed Al; Yan, Jianchang; Wei, Tongbo; Zhang, Yun; Wang, Junxi

    2016-12-01

    Avalanche photodiode (APD) has been intensively investigated as a promising candidate to replace the bulky and fragile photomultiplier tube (PMT) for weak light detection. However, the performance of most available APDs is barely satisfactory compared to that of the PMTs because of inter-valley scattering. Here, we demonstrate a PMT-like APD based on GaN/AlN periodically stacked-structure (PSS), in which the electrons encounter a much less inter-valley scattering during transport than holes. Uni-directional avalanche takes place with a high efficiency. According to our simulations based on a PSS with GaN (10 nm)/AlN (10 nm) in each period, the probability for electrons to trigger ionization in each cycle can reach as high as 80%, while that for holes is only 4%. A record high and stable gain (104) with a low ionization coefficient ratio of 0.05 is demonstrated under a constant bias in a prototype device.

  4. The role of high loop gain induced by intermittent hypoxia in the pathophysiology of obstructive sleep apnoea.

    Science.gov (United States)

    Deacon, Naomi L; Catcheside, Peter G

    2015-08-01

    Intermittent hypoxia and unstable breathing are key features of obstructive sleep apnoea (OSA), the most common pathological problem of breathing in sleep. Unstable ventilatory control is characterised by high loop gain (LG), and likely contributes to cyclical airway obstruction by promoting airway collapse during periods of low ventilatory drive. Potential new strategies to treat OSA include manipulations designed to lower LG. However, the contribution of inherent versus induced LG abnormalities in OSA remains unclear. Hence, a better understanding of the mechanisms causing high LG in OSA is needed to guide the design of LG based treatments. OSA patients exhibit abnormal chemoreflex control which contributes to increased LG. These abnormalities have been shown to normalise after continuous positive airway pressure treatment, suggesting induced rather than inherent trait abnormalities. Experimental intermittent hypoxia, mimicking OSA, increases hypoxic chemosensitivity and induces long term facilitation; a sustained increase in ventilatory neural output which outlasts the original stimulus. These neuroplastic changes induce the same abnormalities in chemoreflex control as seen in OSA patients. This review outlines the evidence to support that a key component of high LG in OSA is induced by intermittent hypoxia, and is reversed by simply preventing this inducing stimulus.

  5. A high-protein breakfast prevents body fat gain, through reductions in daily intake and hunger, in "Breakfast skipping" adolescents.

    Science.gov (United States)

    Leidy, Heather J; Hoertel, Heather A; Douglas, Steve M; Higgins, Kelly A; Shafer, Rebecca S

    2015-09-01

    The purpose of this study was to examine whether the daily consumption of normal-protein (NP) vs. high-protein (HP) breakfast meals improves appetite control, food intake, and body composition in "breakfast skipping" young people with overweight/obesity. Fifty-seven adolescents (age: 19 ± 1 years; BMI: 29.7 ± 4.6 kg m(-2)) completed a 12-week randomized controlled trial in which the adolescents consumed either a 1,464 kJ NP breakfast (13 g protein) or a HP breakfast (35 g protein) or continued to skip breakfast (CON). Pre- and post-study appetite, food intake, body weight, and body composition were assessed. Time-by-group interactions (P fat mass, daily intake, and perceived hunger. Specifically, HP prevented fat mass gains over the 12 weeks (-0.4 ± 0.5 kg) vs. CON (+1.6 ± 0.9 kg; P = 0.02), whereas NP did not (+0.3 ± 0.5 kg). HP led to reductions in daily intake (-1,724 ± 954 kJ) vs. CON (+1,556 ± 745 kJ; P = 0.03), whereas NP did not (+494 ± 213 kJ). Lastly, only the HP group experienced reductions in daily hunger vs. CON (P fat gain, voluntary reductions in daily intake, and reductions in daily hunger in breakfast skipping adolescents with overweight/obesity. © 2015 The Obesity Society.

  6. Fabrication and materials for magneto-photonic assemblies for high-gain antenna applications at GHz frequencies

    Science.gov (United States)

    Zhang, Lanlin

    Recent magnetic photonic assembly (MPA) designs for high-gain antennas contain arrays of low-loss, anisotropic dielectrics and ferrimagnetic materials. Anisotropic dielectrics (AD) are fabricated from laminates, which consist of two ceramics with largely different permittivity and low dielectric losses at GHz frequencies. High gain has been demonstrated in a prototype antenna with 2 sets of 3 mutually rotated AD layers. These layers were made from laminates of commercially available alpha-Al2O3 and Nd-doped barium titanate. Equivalent permittivity tensors and loss tangents (tan delta˜1.9x10-3) were characterized using a resonant cavity based approach, coupled with a finite-element method (FEM) full-wave solver. To enable further minimization of dielectric loss (tan delta), dense high-purity alpha-Al2O3 and TiO2 were prepared starting from colloidally stabilizing the powders in aqueous HNO3 or NH3. After colloidal filtration and sintering, alpha-Al 2O3 with >97.9% density was achieved at a sintering temperature of 1300°C, and TiO2 with >99.5% density was obtained at 1000°C. These low sintering temperatures are ascribed to excellent compact homogeneity. TiO2 was obtained with tan delta of 1.4x10-4 at 6.4 GHz at room temperature. This relatively low value is attributed to the homogeneous dense microstructure with 2.2 mum grain size. Al 3+ was doped into TiO2 using a modified infiltration method to compensate for the effect of Ti4+ reduction. A homogeneous microstructure and doping concentration were also observed in the doped dense TiO2. Substituted Y3Fe5O12 (YIG) garnet was chosen as the ferrimagnetic (F) component, due to its pronounced Faraday rotation effect and potentially low magnetic and dielectric loss. Phase pure garnet was prepared by using the citric-gel method. The magnetic properties were studied for Ca,V,Zr-substituted YIG (CVZG) and as-prepared particle morphology. Compacts of CVZG submicron particles were found to possess a low loss at GHz

  7. The Niemann-Pick C1 gene interacts with a high-fat diet to promote weight gain through differential regulation of central energy metabolism pathways.

    Science.gov (United States)

    Castillo, Joseph J; Jelinek, David; Wei, Hao; Gannon, Nicholas P; Vaughan, Roger A; Horwood, L John; Meaney, F John; Garcia-Smith, Randi; Trujillo, Kristina A; Heidenreich, Randall A; Meyre, David; Orlando, Robert A; LeBoeuf, Renee C; Garver, William S

    2017-08-01

    A genome-wide association study (GWAS) reported that common variation in the human Niemann-Pick C1 gene (NPC1) is associated with morbid adult obesity. This study was confirmed using our BALB/cJ Npc1 mouse model, whereby heterozygous mice (Npc1(+/-) ) with decreased gene dosage were susceptible to weight gain when fed a high-fat diet (HFD) compared with homozygous normal mice (Npc1(+/+) ) fed the same diet. The objective for our current study was to validate this Npc1 gene-diet interaction using statistical modeling with fitted growth trajectories, conduct body weight analyses for different measures, and define the physiological basis responsible for weight gain. Metabolic phenotype analysis indicated no significant difference between Npc1(+/+) and Npc1(+/-) mice fed a HFD for food and water intake, oxygen consumption, carbon dioxide production, locomotor activity, adaptive thermogenesis, and intestinal lipid absorption. However, the livers from Npc1(+/-) mice had significantly increased amounts of mature sterol regulatory element-binding protein-1 (SREBP-1) and increased expression of SREBP-1 target genes that regulate glycolysis and lipogenesis with an accumulation of triacylglycerol and cholesterol. Moreover, white adipose tissue from Npc1(+/-) mice had significantly decreased amounts of phosphorylated hormone-sensitive lipase with decreased triacylglycerol lipolysis. Consistent with these results, cellular energy metabolism studies indicated that Npc1(+/-) fibroblasts had significantly increased glycolysis and lipogenesis, in addition to significantly decreased substrate (glucose and endogenous fatty acid) oxidative metabolism with an accumulation of triacylglycerol and cholesterol. In conclusion, these studies demonstrate that the Npc1 gene interacts with a HFD to promote weight gain through differential regulation of central energy metabolism pathways. Copyright © 2017 the American Physiological Society.

  8. Submonolayer InGaAs/GaAs quantum-dot lasers with high modal gain and zero-linewidth enhancement factor

    DEFF Research Database (Denmark)

    Xu, Zhangcheng; Birkedal, Dan; Juhl, Michael

    2004-01-01

    The gain spectra of a submonolayer (SML) InGaAs/GaAs quantum dot (QD) laser working at 30°C were measured using the Hakki–Paoli method. It is found that the maximum modal gain of QD ground states is as high as 44 cm–1 and no gain saturation occurs below the threshold at the lasing wavelength of 964.......1 nm. When the injection current is about 0.98 times the threshold, the gain spectrum becomes symmetric with respect to the lasing wavelength, and zero-linewidth enhancement factor is observed. These properties are attributed to the high density and the high uniformity of SML QDs in our laser diode....

  9. Ultra-high, broadband gain in a lattice-engineered, Yb-doped double tungstate channel waveguide

    NARCIS (Netherlands)

    Geskus, D.; Aravazhi, S.; Bernhardi, E.H.; Agazzi, L.; García-Blanco, S.M.; Pollnau, M.

    2012-01-01

    150 dB/cm gain over 55 nm wavelength range between 977-1032 nm is obtained in a 47.5% Yb-doped potassium double tungstate waveguide amplifier. The dependence of luminescence lifetime and gain on Yb concentration is investigated.

  10. Design of analog front-end circuitry with drift removal and gain enhancement for a highly sensitive handheld impedance cytometer

    Science.gov (United States)

    Talukder, Niloy

    We present a portable system for personalized blood cell counting consisting of a microfluidic impedance cytometer with portable analog readout feeding into an analog-to-digital converter (ADC). The novel design of the analog readout, which consists of a lock-in-amplifier followed by a high-pass filter stage for subtraction of drift and DC offset, and a post-subtraction high gain stage, enables detection of particles and cells as small as 1 mum in diameter, despite using a low-end 8 bit ADC. Applications such as personalized health monitoring require robust device operation and resilience to clogging, thus it is desirable to avoid using channels comparable in size to the particles being detected, thus requiring high levels of sensitivity. Despite using low-end off-the-shelf hardware, our sensing platform was capable of detecting changes in impedance as small as 0.032%, allowing detection of 3 mum diameter particles in 300 mum wide channel. The consecutive upward and downward signature of recorded peaks further helps to differentiate the signal from the noise floor. The performance of our system is comparable to that of a high-end bench-top impedance spectrometer under experimental condition. The novel analog design allowed for an instrument with a footprint of less than 80 cm2. The aim of this work was to demonstrate the potential of using microfluidic impedance spectroscopy for low-cost health monitoring. We demonstrated the utility of the platform technology towards cell counting, however our platform is broadly applicable to assaying wide panels of biomarkers including proteins, nucleic acids, and various cell types.

  11. An indirect flat-panel detector with avalanche gain for low dose x-ray imaging: SAPHIRE (scintillator avalanche photoconductor with high resolution emitter readout)

    Science.gov (United States)

    Zhao, Wei; Li, Dan; Rowlands, J. A.; Egami, N.; Takiguchi, Y.; Nanba, M.; Honda, Y.; Ohkawa, Y.; Kubota, M.; Tanioka, K.; Suzuki, K.; Kawai, T.

    2008-03-01

    An indirect flat-imager with programmable avalanche gain and field emitter array (FEA) readout is being investigated for low-dose x-ray imaging with high resolution. It is made by optically coupling a structured x-ray scintillator CsI (Tl) to an amorphous selenium (a-Se) avalanche photoconductor called HARP (high-gain avalanche rushing photoconductor). The charge image created by HARP is read out by electron beams generated by the FEA. The proposed detector is called SAPHIRE (Scintillator Avalanche Photoconductor with HIgh Resolution Emitter readout). The avalanche gain of HARP depends on both a-Se thickness and applied electric field E Se. At E Se of > 80 V/μm, the avalanche gain can enhance the signal at low dose (e.g. fluoroscopy) and make the detector x-ray quantum noise limited down to a single x-ray photon. At high exposure (e.g. radiography), the avalanche gain can be turned off by decreasing E Se to < 70 V/μm. In this paper the imaging characteristics of the FEA readout method, including the spatial resolution and noise, were investigated experimentally using a prototype optical HARP-FEA image sensor. The potential x-ray imaging performance of SAPHIRE, especially the aspect of programmable gain to ensure wide dynamic range and x-ray quantum noise limited performance at the lowest exposure in fluoroscopy, was investigated.

  12. Double-pass high-gain low-noise EDFA over S- and C+L-bands by tunable fundamental-mode leakage loss.

    Science.gov (United States)

    Hung, Chi-Ming; Chen, Nan-Kuang; Lai, Yinchieh; Chi, Sien

    2007-02-19

    We demonstrate a high-gain low-noise double-pass tunable EDFA over S- and C+L-bands by discretely introducing fundamental-mode leakage loss in a 16-m-long standard C-band Er(3+)-doped fiber. The amplified spontaneous emission at the wavelengths of longer than 1530 nm can be substantially attenuated by the ASE suppressing filters to maintain high population inversion and to squeeze out the optical gain for S-band signals. When the filters are disabled, the gain bandwidth immediately returns back to the C+L-bands. Under S-band operation, a 37 dB small signal gain and a minimum 4.84 dB noise figure at 1486.9 nm are achieved with a 980 nm pump power of 154 mW.

  13. Very high-gain and low-excess noise near-infrared single-photon avalanche detector: an NIR solid state photomultiplier

    Science.gov (United States)

    Linga, Krishna; Yevtukhov, Yuriy; Liang, Bing

    2009-05-01

    A new family of photodetectors with a Discrete Amplification (DA) mechanism allows the realization of very high gain and low excess noise factor in the visible and near infrared spectral regions and offers an alternative to conventional photomultiplier tubes and Geiger mode avalanche photodetectors. These photodetectors can operate in linear detection mode with gain-bandwidth product in excess of 4X1014 and in photon counting mode with count rates up to 108 counts/sec. Potential benefits of this technology over conventional avalanche photodetectors include ultra low excess noise factor, very high gain, and lower reset time (photodetectors in the near infrared wavelength range. The measured devices have the following performance characteristics: gain > 2X105, excess noise factor Lidar, quantum cryptography, night vision and other military, defence and aerospace applications.

  14. High-Activity Dealloyed Catalysts

    Energy Technology Data Exchange (ETDEWEB)

    Kongkanand, Anusorn [General Motors LLC, Pontiac, MI (United States)

    2014-09-30

    Reduction of costly Pt usage in proton exchange membrane fuel cell electrodes is one of the major challenges towards development and commercialization of fuel cell vehicles. Although few have met the initial-kinetic activity requirements in a realistic fuel cell device, no catalyst material has ever met the demanding fuel cell durability targets set by DOE. In this project, a team of 4 universities and 2 companies came together to investigate a concept that appeared promising in preliminary non-fuel cell tests then to further develop the catalyst to a mature level ready for vehicle implementation. The team consists of academia with technical leadership in their respective areas, a catalyst supplier, and a fuel cell system integrator.The tightly collaborative project enabled development of a highly active and durable catalyst with performance that significantly exceeds that of previous catalysts and meets the DOE targets for the first time (Figure 1A). The catalyst was then further evaluated in full-active-area stack in a realistic vehicle operating condition (Figure 1B). This is the first public demonstration that one can realize the performance benefit and Pt cost reduction over a conventional pure Pt catalyst in a long-term realistic PEMFC system. Furthermore, systematic analyses of a range of catalysts with different performance after fuel cell testing allowed for correlation between catalyst microstructure and its electrocatalytic activity and durability. This will in turn aid future catalyst development.

  15. Parameter analysis for a high-gain harmonic generation FEL using a recently developed 3D polychromatic code

    CERN Document Server

    Biedron, S G; Yu, L H

    2000-01-01

    One possible design for a fourth-generation light source is the high-gain harmonic generation (HGHG) free-electron laser (FEL). Here, a coherent seed with a wavelength at a subharmonic of the desired output radiation interacts with the electron beam in an energy-modulating section. This energy modulation is then converted into spatial bunching while traversing a dispersive section (a three-dipole chicane). The final step is passage through an undulator tuned to the desired higher harmonic output wavelength. The coherent seed serves to suppress and can be at a much lower subharmonic of the output radiation. Recently, a 3D code that includes multiple frequencies, multiple undulators (both in quantity and/or type), quadrupole magnets, and dipole magnets was developed to easily simulate HGHG. Here, a brief review of the HGHG theory, the code development, the Accelerator Test Facility's (ATF) HGHG FEL experimental parameters, and the parameter analysis from simulations of this specific experiment will be discussed...

  16. Fuzzy PI Controller Based Fault Analysis and Recovery in Sensorless BLDC Motor using High Gain Hybrid Converter (HGHC

    Directory of Open Access Journals (Sweden)

    R. Jayanthi

    2014-12-01

    Full Text Available Renewable Energy Sources (RES has been widely used in various applications due to increase in power demand. In this study, a High Gain Hybrid Converter (HGHC has been used to utilize maximum power from PV panel and to control the battery mode of operation such as charging/discharging in an efficient manner. In the load side, sensor less BLDC motor has been used in this study. After the back EMF is generated in the load side BLDC motor, it is taken as feedback to the HGHC. So, this will act as the main supply and thus, more power can be saved. Moreover, this research study also focuses on the transient analysis of the BLDC motor. The inverter in BLDC motor plays a vital role as it is responsible for flux generation and fixing up of angle ‘θ’ to the motor for its operation. So, the failures in the switches of the inverter would greatly affect the overall functioning of the BLDC motor. Thus, this research study focuses on the failure analysis of these switches in the inverter. In order to analyze and recover these faults, error controllers have been used in this proposed study. The simulations are carried out in MATLAB r2011a and the results are taken. The results show the significant performance of the proposed model.

  17. Sensor fault detection and isolation via high-gain observers: application to a double-pipe heat exchanger.

    Science.gov (United States)

    Escobar, R F; Astorga-Zaragoza, C M; Téllez-Anguiano, A C; Juárez-Romero, D; Hernández, J A; Guerrero-Ramírez, G V

    2011-07-01

    This paper deals with fault detection and isolation (FDI) in sensors applied to a concentric-pipe counter-flow heat exchanger. The proposed FDI is based on the analytical redundancy implementing nonlinear high-gain observers which are used to generate residuals when a sensor fault is presented (as software sensors). By evaluating the generated residual, it is possible to switch between the sensor and the observer when a failure is detected. Experiments in a heat exchanger pilot validate the effectiveness of the approach. The FDI technique is easy to implement allowing the industries to have an excellent alternative tool to keep their heat transfer process under supervision. The main contribution of this work is based on a dynamic model with heat transfer coefficients which depend on temperature and flow used to estimate the output temperatures of a heat exchanger. This model provides a satisfactory approximation of the states of the heat exchanger in order to allow its implementation in a FDI system used to perform supervision tasks.

  18. Inhibitory effects of Leonurus sibiricus on weight gain after menopause in ovariectomized and high-fat diet-fed mice.

    Science.gov (United States)

    Kim, Jangseon; Kim, Mi Hye; Choi, You Yeon; Hong, Jongki; Yang, Woong Mo

    2016-07-01

    Leonurus sibiricus, also called motherwort, is a well-known functional food and medicinal herb. It has been known to possess beneficial properties for women's health, especially for aged women. Estrogen deficiency in the menopause could induce lipid metabolic abnormalities in body fat, resulting in obesity. In this study, the inhibitory effects of L. sibiricus on obesity after the menopause were investigated. Female C57BL/6 mice were ovariectomized and fed high-fat diet (HFD) for 12 weeks. Following an induction period, aqueous extracts of L. sibiricus (LS) were orally administrated for 6 weeks. The body, uterine, and visceral fat weights were measured immediately after the animals were killed. Histological analysis was performed to monitor fat and liver. Serum levels of glucose, triglyceride, total cholesterol, and LDL-cholesterol were evaluated. In addition, the expression of lipases was analyzed. Total body weight was significantly decreased by LS treatment. Histological changes in adipocyte size were shown along with a decrease of visceral fat weight in the LS-treated group. In addition, the fat infiltration of liver was reduced by LS administration. LS-treated mice experienced decreases of serum triglyceride, total cholesterol, and LDL-cholesterol levels. The expression of HSL and ATGL was significantly increased by LS treatment. These results suggest that LS could regulate the lipid metabolism via an increase of lipases expression in ovariectomized and HFD-fed mice. LS might be a novel candidate for a functional food to inhibit weight gain after the menopause.

  19. Wavelength-Dependent Transient Characteristics Caused by Gain Saturation in Highly Nonlinear Fiber-Based Raman Amplifiers

    Institute of Scientific and Technical Information of China (English)

    Shinobu; Tamaoki; Tetsufumi; Tsuzaki; Motoki; Kakui; Masayuki; Shigematsu

    2003-01-01

    We have investigated the transient characteristics of discrete Raman Amplifiers and found that the response time caused by gain saturation is dependent upon the wavelength, which corresponds to the effective length of the pump light.

  20. NEU-P11, a novel melatonin agonist, inhibits weight gain and improves insulin sensitivity in high-fat/high-sucrose-fed rats.

    Science.gov (United States)

    She, Meihua; Deng, Xiaojian; Guo, Zhenyu; Laudon, Moshe; Hu, Zhuowei; Liao, Duanfang; Hu, Xiaobo; Luo, Yi; Shen, Qingyun; Su, Zehong; Yin, Weidong

    2009-04-01

    Evidences indicate that a complex relationship exists among sleep disorders, obesity and insulin resistance. NEU-P11 is a novel melatonin agonist used in treatment of psychophysiological insomnia, and in animal studies NEU-P11 showed sleep-promoting effect. In this study, we applied NEU-P11 on obese rats to assess its potential melatoninergic effects in vivo. Obese models were established using high-fat/high-sucrose-fed for 5 months. NEU-P11 (10mg/kg)/melatonin (4mg/kg)/vehicle were administered by a daily intraperitoneal injection respectively for 8 weeks. Our results showed that NEU-P11 or melatonin inhibited both body weight gain and deposit of abdominal fat with no influence on food intake. The impaired insulin sensitivity and antioxidative potency were improved and the levels of plasma glucose, total cholesterol (TC), triglycerides (TG) decreased with an increased in HDL-cholesterol (HDL-c) after NEU-P11 or melatonin administration. These data suggest that NEU-P11, like melatonin, decreased body weight gain and improved insulin sensitivity and metabolic profiles in obese rats. We conclude that NEU-P11 has a melatoninergic effect on regulating body weight in obese rats and also improving metabolic profiles and efficiently enhancing insulin sensitivity.

  1. Positive Effect of Severe Nakagami-m Fading on the Performance of Multiuser TAS/MRC Systems with High Selection Gain

    Directory of Open Access Journals (Sweden)

    Chia-Chun Hung

    2012-01-01

    Full Text Available This paper investigates the positive effect of severe Nakagami-m fading on the performance of multiuser transmit antenna selection/maximal-ratio combining (TAS/MRC systems with high selection gain. Both amount of fading (AF and symbol error rate (SER of M-QAM are derived as closed-form expressions for integer m. For arbitrary m, the AF and the SER are expressible as a single infinite series of Gamma function and Gauss hypergeometric function, respectively. The analytical results lead to the following observations. First, the SER performance can demonstrate the positive effect of severe Nakagami-m fading on multiuser TAS/MRC systems with high selection gain. Second, the AF performance only exhibits the negative impact of severe fading regardless of high selection gain. Last, the benefit of severe fading to the system performance diminishes at high signal-to-noise ratio (SNR.

  2. Performance, carcass characteristics and gain cost of feedlot cattle fed a high level of concentrate and different feed additives

    Directory of Open Access Journals (Sweden)

    Érico Rodrigues

    2013-01-01

    Full Text Available The objective of this study was to evaluate the effects of feeding cattle with isoprotein and isoenergetic diets, with and without the addition of polyclonal antibody preparation (PAP, yeasts (YST or monensin sodium (MON on performance, carcass characteristics and gain cost in feedlot. Ninety-five 20-month old bullocks (323.3±21.8 kg were distributed in 25 pens. The completely randomized experimental design had a 2 × 2 + 1 factorial arrangement and the treatments were replicated 5 times. There was no effect of MON for DMI throughout the feedlot period; however, MON reduced the dry matter intake (DMI in g/kg of BW in the first 28 days when compared with the other treatments. The gain cost decreased with MON addition in relation to the other treatments. Inclusion of YST decreased average daily gain (ADG, final body weight, hot carcass weight, carcass weight, gain to feed ratio and DMI in g/kg body weight, worsening feed conversion and increasing the gain cost in the feeding periods. Inclusion of PAP increased ADG and decreased the gain cost, besides improving feed conversion. For MON and PAP, a difference was found for kidney-pelvic fat and kidney-pelvic fat per 100 kg of hot carcass weight. For MON and YST, there was a difference in ADG, feed conversion, gain cost and carcass yield and kidney-pelvic fat per 100 kg of hot carcass. Treatment YST worsened performance in relation to the non-supplemented treatments. Feeding PAP to animals did not influence performance and carcass characteristics of bullocks in feedlot negatively. Thus, PAP shows potential to substitute MON in cattle feeding using isoprotein and isoenergetic diets.

  3. Net Gains

    Science.gov (United States)

    Fielker, David

    2008-01-01

    The Easter conference 2008 had several activities which for the author raised the same questions on cube nets in some work with eight-year-olds some time ago. In this article, the author muses on some problems from the Easter conference regarding nets of shapes. (Contains 1 note.)

  4. A High-Protein Diet Reduces Weight Gain, Decreases Food Intake, Decreases Liver Fat Deposition, and Improves Markers of Muscle Metabolism in Obese Zucker Rats

    Directory of Open Access Journals (Sweden)

    William W. French

    2017-06-01

    Full Text Available A primary factor in controlling and preventing obesity is through dietary manipulation. Diets higher in protein have been shown to improve body composition and metabolic health during weight loss. The objective of this study was to examine the effects of a high-protein diet versus a moderate-protein diet on muscle, liver and fat metabolism and glucose regulation using the obese Zucker rat. Twelve-week old, male, Zucker (fa/fa and lean control (Fa/fa rats were randomly assigned to either a high-protein (40% energy or moderate-protein (20% energy diet for 12 weeks, with a total of four groups: lean 20% protein (L20; n = 8, lean 40% protein (L40; n = 10, obese 20% protein (O20; n = 8, and obese 40% protein (O40; n = 10. At the end of 12 weeks, animals were fasted and euthanized. There was no difference in food intake between L20 and L40. O40 rats gained less weight and had lower food intake (p < 0.05 compared to O20. O40 rats had lower liver weight (p < 0.05 compared to O20. However, O40 rats had higher orexin (p < 0.05 levels compared to L20, L40 and O20. Rats in the L40 and O40 groups had less liver and muscle lipid deposition compared to L20 and L40 diet rats, respectively. O40 had decreased skeletal muscle mechanistic target of rapamycin complex 1 (mTORC1 phosphorylation and peroxisome proliferator-activated receptor gamma (PPARγ mRNA expression compared to O20 (p < 0.05, with no difference in 5′ AMP-activated protein kinase (AMPK, eukaryotic translation initiation factor 4E binding protein 1 (4EBP1, protein kinase B (Akt or p70 ribosomal S6 kinase (p70S6K phosphorylation. The data suggest that high-protein diets have the potential to reduce weight gain and alter metabolism, possibly through regulation of an mTORC1-dependent pathway in skeletal muscle.

  5. The study of electromagnetic wave propagation in photonic crystals via planewave based transfer (scattering) matrix method with active gain material applications

    Science.gov (United States)

    Li, Ming

    In this dissertation, a set of numerical simulation tools are developed under previous work to efficiently and accurately study one-dimensional (1D), two-dimensional (2D), 2D slab and three-dimensional (3D) photonic crystal structures and their defects effects by means of spectrum (transmission, reflection, absorption), band structure (dispersion relation), and electric and/or magnetic fields distribution (mode profiles). Further more, the lasing property and spontaneous emission behaviors are studied when active gain materials are presented in the photonic crystal structures. First, the planewave based transfer (scattering) matrix method (TMM) is described in every detail along with a brief review of photonic crystal history (Chapter 1 and 2). As a frequency domain method, TMM has the following major advantages over other numerical methods: (1) the planewave basis makes Maxwell's Equations a linear algebra problem and there are mature numerical package to solve linear algebra problem such as Lapack and Scalapack (for parallel computation). (2) Transfer (scattering) matrix method make 3D problem into 2D slices and link all slices together via the scattering matrix (S matrix) which reduces computation time and memory usage dramatically and makes 3D real photonic crystal devices design possible; and this also makes the simulated domain no length limitation along the propagation direction (ideal for waveguide simulation). (3) It is a frequency domain method and calculation results are all for steady state, without the influences of finite time span convolution effects and/or transient effects. (4) TMM can treat dispersive material (such as metal at visible light) naturally without introducing any additional computation; and meanwhile TMM can also deal with anisotropic material and magnetic material (such as perfectly matched layer) naturally from its algorithms. (5) Extension of TMM to deal with active gain material can be done through an iteration procedure with gain

  6. Effect of computer mouse gain and visual demand on mouse clicking performance and muscle activation in a young and elderly group of experienced computer users

    DEFF Research Database (Denmark)

    Sandfeld, Jesper; Jensen, Bente R.

    2005-01-01

    The present study evaluated the specific effects of motor demand and visual demands on the ability to control motor output in terms of performance and muscle activation. Young and elderly subjects performed multidirectional pointing tasks with the computer mouse. Three levels of mouse gain...... was only to a minor degree influenced by mouse gain (and target sizes) indicating that stability of the forearm/hand is of significance during computer mouse control. The study has implications for ergonomists, pointing device manufacturers and software developers....

  7. Fructans from Agave tequilana with a Lower Degree of Polymerization Prevent Weight Gain, Hyperglycemia and Liver Steatosis in High-Fat Diet-Induced Obese Mice.

    Science.gov (United States)

    Márquez-Aguirre, A L; Camacho-Ruíz, R M; Gutiérrez-Mercado, Y K; Padilla-Camberos, E; González-Ávila, M; Gálvez-Gastélum, F J; Díaz-Martínez, N E; Ortuño-Sahagún, D

    2016-12-01

    Fructans from agave have received specific attention because of their highly branched fructan content. We have previously reported that the degree of polymerization (dp) influences their biological activity. Therefore, the aim of this study was to investigate the effect of unfractionated and fractionated fructans (higher and lower dps) from Agave tequilana in high-fat diet-induced (HFD) obese mice. Fructans with a lower dp (HFD+ScF) decreased weight gain by 30 %, body fat mass by 51 %, hyperglycemia by 25 % and liver steatosis by 40 %. Interestingly, unfractionated fructans (HFD+F) decreased glucose and triglycerides (TG), whereas fractionated fructans with a higher dp (HFD+LcF) decreased TG but not glucose; in contrast, HFD+ScF decreased glucose but not TG. Our findings suggest that both higher and lower dp agave fructans have complementary effects in metabolic disorders related to obesity. These findings may contribute to the development of improved food supplements with a specific ratio combination of fructans with different dps.

  8. Giant enhancement of optical high-order sideband generation and their control in a dimer of two cavities with gain and loss

    Science.gov (United States)

    Li, Jiahui; Li, Jiahua; Xiao, Qian; Wu, Ying

    2016-06-01

    Parity-time (PT ) symmetric systems, which rely on the balanced gain-loss condition and render the Hamiltonian non-Hermitian, have provided a new platform to engineer effective light-matter interactions in recent years. Here we explore the high-order sideband features of the output fields obtained from a PT -symmetric optical system consisting of a passive nonlinear cavity coupled to an active linear cavity. By employing a perturbation technique, we derive analytic formulas used to determine the nonlinear transmission coefficient of optical second-order sideband in this structure. Using experimentally achievable parameters, it is clearly shown that the efficiency of the second-order sideband generation can be greatly enhanced in the PT -symmetric dimer, extremely in the vicinity of the transition point from unbroken- to broken-PT regimes. Moreover, we further analyzed the influences of the system parameters, including the photon-tunneling rate between two cavities, Kerr nonlinearity strength, and optical detuning, on the second-order sideband generation. Subsequently we investigate the higher-order sideband output spectrum by numerical simulations, where the sideband amplitude also is largely enhanced in the PT -symmetric arrangement, compared with the passive-passive double-cavity system. Our obtained results provide a new avenue for acquiring optical high-order sidebands and operating light, which may inspire further applications in chip-scale optical communications and optical frequency combs.

  9. Metamaterials with Gain

    Science.gov (United States)

    Hess, Ortwin

    2012-02-01

    Nanoplasmonic metamaterials are the key to an extreme control of light and allow us to conceive materials with negative or vanishing refractive index. Indeed, metamaterials enable a multitude of exciting and useful applications, such as subwavelength focusing, invisibility cloaking, and ``trapped rainbow'' stopping of light. The realization of these materials has recently advanced from the microwave to the optical regime. However, at optical wavelengths, metamaterials may suffer from high dissipative losses owing to the metallic nature of their constituent nanoplasmonic meta-molecules. It is therefore not surprising that overcoming loss restrictions by gain is currently one of the most important topics in metamaterials' research. At the same time, providing gain on the nanoplasmonic (metamolecular) level opens up exciting new possibilities such as a whole new type of metamaterial nano-laser with a cavity length of about a tenth of the wavelength. The talk gives an overview of the state of the art of gain-enhanced metamaterials. Particular focus will be placed on nano-plasmonic metamaterials (such as double-fishnet metamaterials) with integrated laser dyes as gain medium. The successful compensation of loss by gain is demonstrated on the meta-molecular level. On the basis of a comprehensive, microscopic Maxwell-Bloch Langevin approach of spatio-temporal light amplification and lasing in gain-enhanced nanoplasmonic (negative-index) metamaterials a methodology based on the discrete Poynting's theorem is introduced that allows dynamic tracing of the flow of electromagnetic energy into and out of ``microscopic'' channels (light field, plasmons, gain medium). It is shown that steady-state amplification can be achieved in nanoplasmonic metamaterials. Finally, a complex spatio-temporal interplay of light-field and coherent absorption dynamics is revealed in the lasing dynamics of a nanoplasmonic gain-enhanced double-fishnet metamaterial.

  10. Time-restricted feeding on weekdays restricts weight gain: A study using rat models of high-fat diet-induced obesity.

    Science.gov (United States)

    Olsen, Magnus Kringstad; Choi, Man Hung; Kulseng, Bård; Zhao, Chun-Mei; Chen, Duan

    2017-05-01

    A recent study reported that a special weekly scheduled time-restricted feeding regimen (TRF), i.e., no food consumption for 15h during the light (inactive) phase per day for 5 weekdays, attenuated the outcome of diverse nutritional challenges in response to high-fat diet in mice. In the present study, we wanted to further test whether this TRF could restrict body weight gain in both juvenile and adult animals when fed a high-fat diet. Fifty male Sprague-Dawley rats at ages from 5 to 27weeks were used. First, we found that freely fed rats with 60% fat diet gained weight significantly, which was associated with more calorie intake (particularly during light phase) than those fed standard food (7% fat). Secondly, we found that TRF restricted high-fat diet-induced weight gain in both groups of juvenile rats (5 and 13weeks of age) compared to freely fed rats with high-fat diet, despite the same levels of 24h-calorie intake during either weekdays or the weekend. Thirdly, we found that TRF did not restrict high-fat diet-induce weight gain in adult rats (27weeks of age). Thus, we suggest that this special TRF regimen could be further tested in humans (particularly young adults) for the purpose of obesity prevention. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  11. Underrepresented minority high school and college students report STEM-pipeline sustaining gains after participating in the Loma Linda University Summer Health Disparities Research Program.

    Directory of Open Access Journals (Sweden)

    Lorena M Salto

    Full Text Available An urgent need exists for graduate and professional schools to establish evidence-based STEM (science, technology, engineering, and math pipeline programs to increase the diversity of the biomedical workforce. An untapped yet promising pool of willing participants are capable high school students that have a strong STEM interest but may lack the skills and the guided mentoring needed to succeed in competitive STEM fields. This study evaluates and compares the impact of the Loma Linda University (LLU Summer Health Disparities Research Program on high school (HS and undergraduate (UG student participants. The primary focus of our summer research experience (SRE is to enhance the research self-efficacy of the participants by actively involving them in a research project and by providing the students with personalized mentoring and targeted career development activities, including education on health disparities. The results of our study show that our SRE influenced terminal degree intent and increased participant willingness to incorporate research into future careers for both the HS and the UG groups. The quantitative data shows that both the HS and the UG participants reported large, statistically significant gains in self-assessed research skills and research self-efficacy. Both participant groups identified the hands-on research and the mentor experience as the most valuable aspects of our SRE and reported increased science skills, increased confidence in science ability and increased motivation and affirmation to pursue a science career. The follow-up data indicates that 67% of the HS participants and 90% of the UG participants graduated from college with a STEM degree; for those who enrolled in graduate education, 61% and 43% enrolled in LLU, respectively. We conclude that structured SREs can be highly effective STEM strengthening interventions for both UG and HS students and may be a way to measurably increase institutional and biomedical

  12. High Gain Rectangular Microstrip Patch Antenna Employing FR4 Substrate for Wi-MAX, LMDS and MMDS Applications

    Directory of Open Access Journals (Sweden)

    Jaspreet Singh

    2016-06-01

    Full Text Available This paper presents an antenna for WiMAX, LMDS and MMDS system applications. FR4 material has been used as substrate having dielectric constant of 4.4. The Patch, Ground and feedline are made of copper. The proposed antenna is rectangular in shape which resonate at 3.42 GHz with a bandwidth of 45MHz (3.40GHz- 3.44GHz and corresponding return loss of -32.39 dB. The performance of the antenna has been analyzed in terms of return loss (dB, gain (dB, directivity (dBi, VSWR and impedance (ohms. The proposed antenna has directivity and gain of 7.2 dBi and 7.28 dB respectively

  13. High energy gain of trapped electrons in a tapered, diffraction-dominated inverse-free-electron laser.

    Science.gov (United States)

    Musumeci, P; Tochitsky, S Ya; Boucher, S; Clayton, C E; Doyuran, A; England, R J; Joshi, C; Pellegrini, C; Ralph, J E; Rosenzweig, J B; Sung, C; Tolmachev, S; Travish, G; Varfolomeev, A A; Varfolomeev, A A; Yarovoi, T; Yoder, R B

    2005-04-22

    Energy gain of trapped electrons in excess of 20 MeV has been demonstrated in an inverse-free-electron-laser (IFEL) accelerator experiment. A 14.5 MeV electron beam is copropagated with a 400 GW CO2 laser beam in a 50 cm long undulator strongly tapered in period and field amplitude. The Rayleigh range of the laser, approximately 1.8 cm, is much shorter than the undulator length yielding a diffraction-dominated interaction. Experimental results on the dependence of the acceleration on injection energy, laser focus position, and laser power are discussed. Simulations, in good agreement with the experimental data, show that most of the energy gain occurs in the first half of the undulator at a gradient of 70 MeV/m and that the structure in the measured energy spectrum arises because of higher harmonic IFEL interaction in the second half of the undulator.

  14. Tea decoctions prevent body weight gain in rats fed high-fat diet; black tea being more efficient than green tea

    Directory of Open Access Journals (Sweden)

    Mohamed Hédi Hamdaoui

    2016-12-01

    Conclusion: Chronic GTD and BTD prevent fat storage in the liver, lowering blood lipids and glucose, increasing fecal excretion of TG, decreasing AT and weight gains in rats fed HFD, with a strong effect of BTD compared to GTD. Therefore, these beverages containing high amounts of TPC and caffeine could constitute a natural alternative in the prevention of obesity.

  15. Bright CuInS2/CdS nanocrystal phosphors for high-gain full-spectrum luminescent solar concentrators.

    Science.gov (United States)

    Knowles, Kathryn E; Kilburn, Troy B; Alzate, Dane G; McDowall, Stephen; Gamelin, Daniel R

    2015-06-04

    The performance of colloidal CuInS2/CdS nanocrystals as phosphors for full-spectrum luminescent solar concentrators has been examined. Their combination of large solar absorption, high photoluminescence quantum yields, and only moderate reabsorption produces the highest projected flux gains of any nanocrystal luminophore to date.

  16. High-gain complementary metal-oxide-semiconductor inverter based on multi-layer WSe2 field effect transistors without doping

    Science.gov (United States)

    Kang, Won-Mook; Cho, In-Tak; Roh, Jeongkyun; Lee, Changhee; Lee, Jong-Ho

    2016-10-01

    A high-gain complementary metal-oxide-semiconductor (CMOS) logic inverter was implemented by fabricating p- and n-type field effect transistors (FETs) based on multi-layer WSe2 on the same wafer. Au as a high work-function metal is contacted to WSe2 for the source/drain of the p-type FET. The n-type FET has an Al electrode contacted to WSe2 for the source/drain. Both FETs were designed to have similar on-current densities (>10-7 A μm-1) and high on/off current ratios (>106). The inverter shows excellent switching characteristics including relatively high voltage gains (>25) and high noise margins (>0.9) in the range of supply voltage from 2 V to 8 V. This work has a great significance in the realization of a CMOS logic gate based on WSe2 without an additional doping scheme.

  17. An novel analog programmable power supply for active gain control of the Multi-Pixel Photon Counter (MPPC)

    CERN Document Server

    Li, Zhengwei; Xu, Yupeng; Yan, Bo; Li, Yanguo; Lu, Xuefeng; Li, Xufang; Zhang, Shuo; Chang, Zhi; Li, Jicheng; Zhang, Yifei; Zhao, Jianling

    2016-01-01

    Silicon Photo-Multipliers (SiPM) are regarded as novel photo-detector to replace conventional Photo-Multiplier Tubes (PMTs). However, the breakdown voltage dependence on the ambient temperature results in a gain variation of $\\sim$3$\\% /^{\\circ} \\mathrm C$. This can severely limit the application of this device in experiments with wide range of operating temperature, especially in space telescope. An experimental setup in dark condition was established to investigate the temperature and bias voltage dependence of gain for the Multi-Pixel Photon Counter (MPPC), one type of the SiPM developed by Hamamatsu. The gain and breakdown voltage dependence on operating temperature of an MPPC can be approximated by a linear function, which is similar to the behavior of a zener diode. The measured temperature coefficient of the breakdown voltage is $(59.4 \\pm 0.4$ mV)$/^{\\circ} \\mathrm C$. According to this fact, a programmable power supply based on two zener diodes and an operational amplifier was designed with a positiv...

  18. High net modal gain (>100 cm(-1)) in 19-stacked InGaAs quantum dot laser diodes at 1000 nm wavelength band.

    Science.gov (United States)

    Tanoue, Fumihiko; Sugawara, Hiroharu; Akahane, Kouichi; Yamamoto, Naokatsu

    2013-07-01

    An InGaAs quantum dot (QD) laser diode with 19-stacked QDs separated by 20 nm-thick GaAs spacers was fabricated using an ultrahigh-rate molecular beam epitaxial growth technique, and the laser characteristics were evaluated. A 19-stacked simple broad area QD laser diode was lased at the 1000 nm waveband. A net modal gain of 103 cm(-1) was obtained at 2.25 kA/cm(2), and the saturated modal gain was 145.6 cm(-1); these are the highest values obtained to our knowledge. These results indicate that using this technique to highly stack QDs is effective for improving the net modal gain of QD lasers.

  19. Merged beam laser design for reduction of gain-saturation and two-photon absorption in high power single mode semiconductor lasers.

    Science.gov (United States)

    Lysevych, M; Tan, H H; Karouta, F; Fu, L; Jagadish, C

    2013-04-08

    In this paper we report a method to overcome the limitations of gain-saturation and two-photon absorption faced by developers of high power single mode InP-based lasers and semiconductor optical amplifiers (SOA) including those based on wide-waveguide or slab-coupled optical waveguide laser (SCOWL) technology. The method is based on Y-coupling design of the laser cavity. The reduction in gain-saturation and two-photon absorption in the merged beam laser structures (MBL) are obtained by reducing the intensity of electromagnetic field in the laser cavity. Standard ridge-waveguide lasers and MBLs were fabricated, tested and compared. Despite a slightly higher threshold current, the reduced gain-saturation in MBLs results in higher output power. The MBLs also produced a single spatial mode, as well as a strongly dominating single spectral mode which is the inherent feature of MBL-type cavity.

  20. High performance polarization-independent Quantum Dot Semiconductor Optical Amplifier with 22 dB fiber to fiber gain using Mode Propagation Tuning without additional polarization controller

    Science.gov (United States)

    Farmani, Ali; Farhang, Mahmoud; Sheikhi, Mohammad H.

    2017-08-01

    A detailed numerical investigation of polarization-independent quantum dot InAs/GaAs semiconductor optical amplifier (PIQS) based on a technique called mode propagation tuning (MPT) without the need for the polarization controller (PC) is reported, which can solve the limitation caused by polarization sensitivity in a semiconductor optical amplifier (SOA). Our calculations show that by a suitable tuning of the thickness of the active layer, only the TE0 and TM0 modes can propagate. Moreover, the gain saturation behavior of this SOA was measured at 1.55 μ m and found to be polarization-independent (PI). At active layer thickness of 1.7 μ m, the confinement factor was 0.75 and 0.7 for TE0 and TM0 modes, respectively, which leads to a gain difference up to 0.1 dB. The rate equations of the QD-SOA were also solved and a fiber to fiber gain of 22 dB was obtained. Additionally, a numerical simulation is presented which shows that the residual gain ripple and polarization sensitivity are sufficiently reduced when residual facet reflectivities of the SOA are in the range below 10-4 . In addition, the full-width at half-maximum of the horizontal and vertical far-field patterns (FFPs) are measured as 30° × 30°. The proposed structure can be used for logical applications.

  1. Activation of the prefrontal cortex by unilateral transcranial direct current stimulation leads to an asymmetrical effect on risk preference in frames of gain and loss.

    Science.gov (United States)

    Ye, Hang; Huang, Daqiang; Wang, Siqi; Zheng, Haoli; Luo, Jun; Chen, Shu

    2016-10-01

    Previous brain imaging and brain stimulation studies have suggested that the dorsolateral prefrontal cortex may be critical in regulating risk-taking behavior, although its specific causal effect on people's risk preference remains controversial. This paper studied the independent modulation of the activity of the right and left dorsolateral prefrontal cortex using various configurations of transcranial direct current stimulation. We designed a risk-measurement table and adopted a within-subject design to compare the same participant's risk preference before and after unilateral stimulation when presented with different frames of gain and loss. The results confirmed a hemispheric asymmetry and indicated that the right dorsolateral prefrontal cortex has an asymmetric effect on risk preference regarding frames of gain and loss. Enhancing the activity of the right dorsolateral prefrontal cortex significantly decreased the participants' degree of risk aversion in the gain frame, whereas it increased the participants' degree of risk aversion in the loss frame. Our findings provide important information regarding the impact of transcranial direct current stimulation on the risk preference of healthy participants. The effects observed in our experiment compared with those of previous studies provide further evidence of the effects of hemispheric and frame-dependent asymmetry. These findings may be helpful in understanding the neural basis of risk preference in humans, especially when faced with decisions involving possible gain or loss relative to the status quo.

  2. Salvianolic Acid B Inhibited PPARγ Expression and Attenuated Weight Gain in Mice with High-Fat Diet-Induced Obesity

    Directory of Open Access Journals (Sweden)

    Peijian Wang

    2014-07-01

    Full Text Available Background/Aims: Obesity contributes to the development of cardiometabolic disorders such as type 2 diabetes, fatty liver disease and cardiovascular disease. Salvianolic acid B (Sal B is a molecule derived from the root of Salvia miltiorrhiza (Danshen, which is a traditional Chinese medicine that is widely used to treat cardiovascular diseases. However, the role of Sal B in obesity and obesity-related metabolic disorders is unknown. In this study, we aimed to investigate the effects of Sal B on high-fat diet-induced obesity and determine the possible mechanisms involved. Methods: Male C57BL/6J mice fed a high-fat diet for 12 weeks received a supplement of Sal B (100 mg/kg/day by gavage for a further 8 weeks. These mice were compared to control mice fed an un-supplemented high-fat diet. 3T3-L1 preadipocytes were used in vitro studies. Results: Sal B administration significantly decreased body weight, white adipose tissue weight, adipocyte size and lipid (triglyceride and total cholesterol levels in obese mice. Eight weeks of Sal B administration also improved the intraperitoneal glucose tolerance test (IPGTT and intraperitoneal insulin tolerance test (IPITT scores in high-fat diet-induced obese mice. In 3T3-L1 preadipocytes that were cultured in vitro and induced to differentiate, Sal B reduced the accumulation of lipid droplets and lipid content in a dose-dependent manner. Immunoblotting indicated that Sal B decreased peroxisome proliferator-activated receptor gamma (PPARγ and CCAAT/enhancer binding protein α (C/EBPα expression but increased the expression of GATA binding protein 2 and 3 (GATA 2, GATA 3 both in vivo and in vitro. Conclusion: Our data suggest that Sal B may reduce obesity and obesity-related metabolic disorders by suppressing adipogenesis. The effects of Sal B in adipose tissue may be related to its action on PPARγ, C/EBPα, GATA-2 and GATA-3.

  3. Carnosic acid-rich rosemary (Rosmarinus officinalis L.) leaf extract limits weight gain and improves cholesterol levels and glycaemia in mice on a high-fat diet.

    Science.gov (United States)

    Ibarra, Alvin; Cases, Julien; Roller, Marc; Chiralt-Boix, Amparo; Coussaert, Aurélie; Ripoll, Christophe

    2011-10-01

    Rosemary (Rosmarinus officinalis L.) extracts (RE) are natural antioxidants that are used in food, food supplements and cosmetic applications; exert anti-inflammatory and anti-hyperglycaemic effects; and promote weight loss, which can be exploited to develop new preventive strategies against metabolic disorders. Therefore, the aim of the present study was to evaluate the preventive effects of rosemary leaf extract that was standardised to 20 % carnosic acid (RE) on weight gain, glucose levels and lipid homeostasis in mice that had begun a high-fat diet (HFD) as juveniles. The animals were given a low-fat diet, a HFD or a HFD that was supplemented with 500 mg RE/kg body weight per d (mpk). Physiological and biochemical parameters were monitored for 16 weeks. Body and epididymal fat weight in animals on the HFD that was supplemented with RE increased 69 and 79 % less than those in the HFD group. Treatment with RE was associated with increased faecal fat excretion but not with decreased food intake. The extract also reduced fasting glycaemia and plasma cholesterol levels. In addition, we evaluated the inhibitory effects of RE in vitro on pancreatic lipase and PPAR-γ agonist activity; the in vitro findings correlated with our observations in the animal experiments. Thus, the present results suggest that RE that is rich in carnosic acid can be used as a preventive treatment against metabolic disorders, which merits further examination at physiological doses in randomised controlled trials.

  4. Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria Diet

    Directory of Open Access Journals (Sweden)

    Saverio Massimo Lepore

    2015-01-01

    Full Text Available The high consumption of olive tree products in the Mediterranean diet has been associated with a lower incidence of metabolic disorders and cardiovascular diseases. In particular, the protective effects of olive oil have been attributed to the presence of polyphenols such as oleuropein (Ole and its derivatives. We have synthesized a peracetylated derivative of Ole (Ac-Ole which has shown in vitro antioxidant and growth-inhibitory activity higher than the natural molecule. In this study, male C57BL/6JOlaHsd mice were fed with a standard (std, cafeteria (caf diet, and caf diet supplemented with Ole (0.037 mmol/kg/day and Ac-Ole (0.025 mmol/kg/day for 15 weeks. We observed a significant reduction in the caf diet-induced body weight gain and increase of abdominal adipose tissue. Also, Ole and Ac-Ole prevented the development of hepatic steatosis. Finally, Ole and Ac-Ole determined a lower increase of HDL and LDL-cholesterol levels and corrected caf diet-induced elevation of plasma glucose concentrations by improving insulin sensitivity. The observed beneficial properties of Ole and Ac-Ole make these compounds and in particular Ac-Ole promising candidates for a potential pharmaceutic use in metabolic disorders.

  5. Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria Diet

    Science.gov (United States)

    Lepore, Saverio Massimo; Morittu, Valeria Maria; Celano, Marilena; Trimboli, Francesca; Oliverio, Manuela; Procopio, Antonio; Di Loreto, Carla; Damante, Giuseppe; Britti, Domenico; Bulotta, Stefania; Russo, Diego

    2015-01-01

    The high consumption of olive tree products in the Mediterranean diet has been associated with a lower incidence of metabolic disorders and cardiovascular diseases. In particular, the protective effects of olive oil have been attributed to the presence of polyphenols such as oleuropein (Ole) and its derivatives. We have synthesized a peracetylated derivative of Ole (Ac-Ole) which has shown in vitro antioxidant and growth-inhibitory activity higher than the natural molecule. In this study, male C57BL/6JOlaHsd mice were fed with a standard (std), cafeteria (caf) diet, and caf diet supplemented with Ole (0.037 mmol/kg/day) and Ac-Ole (0.025 mmol/kg/day) for 15 weeks. We observed a significant reduction in the caf diet-induced body weight gain and increase of abdominal adipose tissue. Also, Ole and Ac-Ole prevented the development of hepatic steatosis. Finally, Ole and Ac-Ole determined a lower increase of HDL and LDL-cholesterol levels and corrected caf diet-induced elevation of plasma glucose concentrations by improving insulin sensitivity. The observed beneficial properties of Ole and Ac-Ole make these compounds and in particular Ac-Ole promising candidates for a potential pharmaceutic use in metabolic disorders. PMID:26798341

  6. Overexpression of Elafin in Ovarian Carcinoma Is Driven by Genomic Gains and Activation of the Nuclear Factor κB Pathway and Is Associated with Poor Overall Survival

    Directory of Open Access Journals (Sweden)

    Adam Clauss

    2010-02-01

    Full Text Available Ovarian cancer is a leading cause of cancer mortality in women. The aim of this study was to elucidate whether whey acidic protein (WAP genes on chromosome 20q13.12, a region frequently amplified in this cancer, are expressed in serous carcinoma, the most common form of the disease. Herein, we report that a trio of WAP genes (HE4, SLPI, and Elafin is overexpressed and secreted by serous ovarian carcinomas. To our knowledge, this is the first report linking Elafin to ovarian cancer. Fluorescence in situ hybridization analysis of primary tumors demonstrates genomic gains of the Elafin locus in a majority of cases. In addition, a combination of peptidomimetics, RNA interference, and chromatin immunoprecipitation experiments shows that Elafin expression can be transcriptionally upregulated by inflammatory cytokines through activation of the nuclear factor κB pathway. Importantly, using a clinically annotated tissue microarray composed of late-stage, high-grade serous ovarian carcinomas, we show that Elafin expression correlates with poor overall survival. These results, combined with our observation that Elafin is secreted by ovarian tumors and is minimally expressed in normal tissues, suggest that Elafin may serve as a determinant of poor survival in this disease.

  7. Insidious weight gain in prepubertal seized rats treated with an atypical neuroleptic: the role of food consumption, fluid consumption, and spontaneous ambulatory activity.

    Science.gov (United States)

    St-Pierre, L S; Bubenik, G A; Parker, G H; Persinger, M A

    2009-02-01

    Extreme obesity slowly develops in female rats over the months following seizures induced by a single systemic injection of lithium and pilocarpine if the resulting limbic seizures are treated with the atypical neuroleptic acepromazine (but not with ketamine). To discern the contributions from food consumption, water consumption, and (daytime and nighttime) activity to this weight gain, these behaviors were monitored for 4 months, about 2 months after seizure induction. The results indicated that the rats that underwent the obesity procedure exhibited 50% heavier body weights and consumed 42% more food than the reference group, which included rats that had been induced to seize but treated with ketamine. There were no statistically significant differences between groups with respect to either water consumption or (daytime or nighttime) activity. Factor analyses of data for individual rats verified the dissociation between activity and weight gain for the obese rats. The results suggest that the progressive weight gains are centrally mediated and are not secondary to diminished activity or altered fluid consumption.

  8. Broadband and high-speed swept external-cavity laser using a quantum-dot superluminescent diode as gain device

    Institute of Scientific and Technical Information of China (English)

    胡发杰; 金鹏; 吴艳华; 王飞飞; 魏恒; 王占国

    2015-01-01

    A wide wavelength tuning range swept external-cavity laser using an InAs/GaAs quantum-dot superluminescent diode as a gain device is demonstrated. The tunable filter consists of a polygon scanner and a grating in Littrow telescope-less configuration. The swept laser generates greater than 54-mW peak output power and up to 33-kHz sweep rate with a sweep range of 150 nm centered at 1155 nm. The effects of injection current and sweep rate on the sweep performance of the swept laser are studied.

  9. Technology developments and first measurements on inverse Low Gain Avalanche Detector (iLGAD) for high energy physics applications

    Science.gov (United States)

    Carulla, M.; Fernández-García, M.; Fernández-Martínez, P.; Flores, D.; González, J.; Hidalgo, S.; Jaramillo, R.; Merlos, A.; Palomo, F. R.; Pellegrini, G.; Quirion, D.; Vila, I.

    2016-12-01

    The first Inverse Low Gain Avalanche Detector (iLGAD) have been fabricated at IMB-CNM (CSIC). The iLGAD structure includes the multiplication diffusions at the ohmic contact side while the segmentation is implemented at the front side with multiple p+ diffusions. Therefore, iLGAD is p on p position-sensitive detector with a uniform electric field all along the device area that guarantees the same signal amplification wherever a particle passes through the sensitive bulk solving the main draw of the LGAD microstrip detector. However, the detection current is dominated by holes flowing back from the multiplication junction with the subsequent increase of the transient current pulse duration in comparison with conventional LGAD counterparts. Applications of iLGAD range from tracking and timing applications, like determination of primary interaction vertex, to medical imaging. The paper addresses the optimization of the iLGAD structure with the aid of TCAD simulations, focusing on the electric field profiles of iLGAD and LGAD microstrip structures and the corresponding gain. The electrical performance of the first fabricated samples is also provided. For the first time, we have the experimental demonstration of the signal amplification of these novel iLGAD detectors.

  10. Physical activity, sedentary time and gain in overall and central body fat : 7-year follow-up of the ProActive trial cohort

    NARCIS (Netherlands)

    Golubic, R.; Wijndaele, K.; Sharp, S. J.; Simmons, R. K.; Griffin, S. J.; Wareham, N. J.; Ekelund, U.; Brage, S.; de Jong, C.

    OBJECTIVE: The objective of this study is to examine the independent associations of time spent in moderate-to-vigorous physical activity (MVPA) and sedentary (SED-time), with total and abdominal body fat (BF), and the bidirectionality of these associations in adults at high risk of type 2 diabetes.

  11. Gain- and Loss-Related Brain Activation Are Associated with Information Search Differences in Risky Gambles: An fMRI and Eye-Tracking Study.

    Science.gov (United States)

    Häusler, Alexander Niklas; Oroz Artigas, Sergio; Trautner, Peter; Weber, Bernd

    2016-01-01

    People differ in the way they approach and handle choices with unsure outcomes. In this study, we demonstrate that individual differences in the neural processing of gains and losses relates to attentional differences in the way individuals search for information in gambles. Fifty subjects participated in two independent experiments. Participants first completed an fMRI experiment involving financial gains and losses. Subsequently, they performed an eye-tracking experiment on binary choices between risky gambles, each displaying monetary outcomes and their respective probabilities. We find that individual differences in gain and loss processing relate to attention distribution. Individuals with a stronger reaction to gains in the ventromedial prefrontal cortex paid more attention to monetary amounts, while a stronger reaction in the ventral striatum to losses was correlated with an increased attention to probabilities. Reaction in the posterior cingulate cortex to losses was also found to correlate with an increased attention to probabilities. Our data show that individual differences in brain activity and differences in information search processes are closely linked.

  12. Technology developments and first measurements on inverse Low Gain Avalanche Detector (iLGAD) for high energy physics applications

    CERN Document Server

    Carulla, M.; Fernández-Martínez, P.; IMB-CNM (CSIC); Flores, D.; IMB-CNM (CSIC); González, J.; Hidalgo, S.; Jaramillo, R.; Merlos, A.; Palomo, F.R.; Pellegrini, G; Quirion, D.; Vila, I.

    2016-01-01

    ABSTRACT: The first Inverse Low Gain Avalanche Detector (iLGAD) have been fabricated at IMB-CNM (CSIC). The iLGAD structure includes the multiplication diffusions at the ohmic contact side while the segmentation is implemented at the front side with multiple P + diffusions. Therefore, iLGAD is P on P position-sensitive detector with a uniform electric field all along the device area that guarantees the same signal amplification wherever a particle passes through the sensitive bulk solving the main draw of the LGAD microstrip detector. However, the detection current is dominated by holes flowing back from the multiplication junction with the subsequent transient current pulse duration increase in comparison with conventional LGAD counterparts. Applications of iLGAD range from tracking and timing applications like determination of primary interaction vertex to medical imaging. The paper addresses the optimization of the iLGAD structure with the aid of TCAD simul...

  13. Active narrowband filtering, line narrowing and gain using ladder electromagnetically induced transparency in an optically thick atomic vapour

    CERN Document Server

    Keaveney, James; Sarkisyan, David; Papoyan, Aram; Adams, Charles S

    2013-01-01

    Electromagnetically induced transparency (EIT) resonances using the $5\\rm{S}_{1/2}\\rightarrow5\\rm{P}_{3/2}\\rightarrow5\\rm{D}_{5/2}$ ladder-system in optically thick Rb atomic vapour are studied. We observe a strong line narrowing effect and gain at the $5\\rm{S}_{1/2}\\rightarrow5\\rm{P}_{3/2}$ transition wavelength due to an energy-pooling assisted frequency conversion with characteristics similar to four-wave mixing. As a result it is possible to observe tunable and switchable transparency resonances with amplitude close to $100\\%$ and a linewidth of 15 MHz. In addition, the large line narrowing effect allows resolution of $^{85}$Rb $5\\rm{D}_{5/2}$ hyperfine structure even in the presence of strong power broadening.

  14. Eight week exposure to a high sugar high fat diet results in adiposity gain and alterations in metabolic biomarkers in baboons (Papio hamadryas sp.

    Directory of Open Access Journals (Sweden)

    Tejero M Elizabeth

    2010-10-01

    Full Text Available Abstract Background Baboons (Papio hamadryas Sp. develop features of the cardiometabolic syndrome and represent a clinically-relevant animal model in which to study the aetiology of the disorder. To further evaluate the baboon as a model for the study of the cardiometabolic syndrome, we developed a high sugar high fat diet and hypothesized that it could be used to induce adiposity gain and affect associated circulating biomarkers. Methods We developed a diet enriched with monosaccharides and saturated fatty acids that was composed of solid and liquid energy sources. We provided a group of baboons (n = 9 ad libitum access to this diet for 8 weeks. Concurrently, a control group (n = 6 was maintained with ad libitum access to a low sugar low fat baseline diet and normal water for 8 weeks. Body composition was determined by dual-energy X-ray absorptiometry and circulating metabolic biomarkers were measured using standard methodology before and after the 8 week study period. Results Neither body composition nor circulating biomarkers changed in the control group. Following the 8 weeks, the intervention group had a significant increase in fat mass (1.71 ± 0.98 vs. 3.23 ± 1.70 kg, p = 0.004, triglyceride (55 ± 13 vs. 109 ± 67 mg/dL, p = 0.006,, and leptin (1.19 ± 1.40 vs. 3.29 ± 2.32 ng/mL, p = 0.001 and a decline in adiponectin concentrations (33530 ± 9744 vs. 23330 ± 7863 ng/mL, p = 0.002. Percentage haemoglobin A1C (4.0 ± 0.3 vs. 6.0 ± 1.4, p = 0.002 also increased in the intervention group. Conclusions Our findings indicate that when exposed to a high sugar high fat diet, young adult male baboons develop increased body fat and triglyceride concentrations, altered adipokine concentrations, and evidence of altered glucose metabolism. Our findings are in keeping with observations in humans and further demonstrate the potential utility of this highly clinically-relevant animal model for studying diet-induced metabolic dysregulation.

  15. Active video games as a tool to prevent excessive weight gain in adolescents: rationale, design and methods of a randomized controlled trial

    Science.gov (United States)

    2014-01-01

    Background Excessive body weight, low physical activity and excessive sedentary time in youth are major public health concerns. A new generation of video games, the ones that require physical activity to play the games –i.e. active games- may be a promising alternative to traditional non-active games to promote physical activity and reduce sedentary behaviors in youth. The aim of this manuscript is to describe the design of a study evaluating the effects of a family oriented active game intervention, incorporating several motivational elements, on anthropometrics and health behaviors in adolescents. Methods/Design The study is a randomized controlled trial (RCT), with non-active gaming adolescents aged 12 – 16 years old randomly allocated to a ten month intervention (receiving active games, as well as an encouragement to play) or a waiting-list control group (receiving active games after the intervention period). Primary outcomes are adolescents’ measured BMI-SDS (SDS = adjusted for mean standard deviation score), waist circumference-SDS, hip circumference and sum of skinfolds. Secondary outcomes are adolescents’ self-reported time spent playing active and non-active games, other sedentary activities and consumption of sugar-sweetened beverages. In addition, a process evaluation is conducted, assessing the sustainability of the active games, enjoyment, perceived competence, perceived barriers for active game play, game context, injuries from active game play, activity replacement and intention to continue playing the active games. Discussion This is the first adequately powered RCT including normal weight adolescents, evaluating a reasonably long period of provision of and exposure to active games. Next, strong elements are the incorporating motivational elements for active game play and a comprehensive process evaluation. This trial will provide evidence regarding the potential contribution of active games in prevention of excessive weight gain in

  16. Natural Killer Cell-Based Therapies Targeting Cancer: Possible Strategies to Gain and Sustain Anti-Tumor Activity

    Science.gov (United States)

    Dahlberg, Carin I. M.; Sarhan, Dhifaf; Chrobok, Michael; Duru, Adil D.; Alici, Evren

    2015-01-01

    Natural killer (NK) cells were discovered 40 years ago, by their ability to recognize and kill tumor cells without the requirement of prior antigen exposure. Since then, NK cells have been seen as promising agents for cell-based cancer therapies. However, NK cells represent only a minor fraction of the human lymphocyte population. Their skewed phenotype and impaired functionality during cancer progression necessitates the development of clinical protocols to activate and expand to high numbers ex vivo to be able to infuse sufficient numbers of functional NK cells to the cancer patients. Initial NK cell-based clinical trials suggested that NK cell-infusion is safe and feasible with almost no NK cell-related toxicity, including graft-versus-host disease. Complete remission and increased disease-free survival is shown in a small number of patients with hematological malignances. Furthermore, successful adoptive NK cell-based therapies from haploidentical donors have been demonstrated. Disappointingly, only limited anti-tumor effects have been demonstrated following NK cell infusion in patients with solid tumors. While NK cells have great potential in targeting tumor cells, the efficiency of NK cell functions in the tumor microenvironment is yet unclear. The failure of immune surveillance may in part be due to sustained immunological pressure on tumor cells resulting in the development of tumor escape variants that are invisible to the immune system. Alternatively, this could be due to the complex network of immune-suppressive compartments in the tumor microenvironment, including myeloid-derived suppressor cells, tumor-associated macrophages, and regulatory T cells. Although the negative effect of the tumor microenvironment on NK cells can be transiently reverted by ex vivo expansion and long-term activation, the aforementioned NK cell/tumor microenvironment interactions upon reinfusion are not fully elucidated. Within this context, genetic modification of NK cells

  17. Gut microbiota Modulated by Probiotics and Garcinia cambogia Extract Correlate with Weight Gain and Adipocyte Sizes in High Fat-Fed Mice

    OpenAIRE

    Jaeyoung Heo; Minseok Seo; Hwanhee Park; Woon Kyu Lee; Le Luo Guan; Joon Yoon; Kelsey Caetano-Anolles; Hyeonju Ahn; Se-Young Kim; Yoon-Mo Kang; Seoae Cho; Heebal Kim

    2016-01-01

    Results of recent studies on gut microbiota have suggested that obesogenic bacteria exacerbate obesity and metabolic dysfunction in the host when fed a high fat diet (HFD). In order to explore obesity-associated bacterial candidates and their response to diet, the composition of faecal bacterial communities was investigated by analyzing 16S rRNA gene sequences in mice. Dietary intervention with probiotics and Garcinia cambogia extract attenuated weight gain and adipocyte size in HFD-fed mice....

  18. Amorphous silicon germanium carbide photo sensitive bipolar junction transistor with a base-contact and a continuous tunable high current gain

    Energy Technology Data Exchange (ETDEWEB)

    Bablich, A., E-mail: andreas.bablich@uni-siegen.de [Department of Electrical and Computer Engineering, Institute for Microsystem Technologies, University of Siegen, Hoelderlinstrasse 3, 57076 Siegen (Germany); Merfort, C., E-mail: merfort@imt.e-technik.uni-siegen.de [Department of Electrical and Computer Engineering, Institute for Microsystem Technologies, University of Siegen, Hoelderlinstrasse 3, 57076 Siegen (Germany); Eliasz, J., E-mail: jacek.eliasz@student.uni-siegen.de [Department of Electrical and Computer Engineering, Institute for Microsystem Technologies, University of Siegen, Hoelderlinstrasse 3, 57076 Siegen (Germany); Schäfer-Eberwein, H., E-mail: heiko.schaefer@uni-siegen.de [Department of Electrical and Computer Engineering, Institute of High Frequency and Quantum Electronics, University of Siegen, Hoelderlinstrasse 3, 57076 Siegen (Germany); Haring-Bolivar, P., E-mail: peter.haring@uni-siegen.de [Department of Electrical and Computer Engineering, Institute of High Frequency and Quantum Electronics, University of Siegen, Hoelderlinstrasse 3, 57076 Siegen (Germany); Boehm, M., E-mail: markus.boehm@uni-siegen.de [Department of Electrical and Computer Engineering, Institute for Microsystem Technologies, University of Siegen, Hoelderlinstrasse 3, 57076 Siegen (Germany)

    2014-05-02

    , the device presented in this paper obtains no optical gain with an incident light power of 0.31 μW and 578 nm wavelength. The PS-BJT exhibits promising characteristics with a maximum current density greater than 65 μA μm{sup −1} and a tunable high current gain β. Possible applications exist in fields of control and drive circuits, in display and image devices, in photo interrupters, in photo sensitive matrices or in optoelectronic switches. - Highlights: • Current controllable a-Si:H phototransistor • Controllable high current gain • Current and phototunable transistor.

  19. A C-band 55% PAE high gain two-stage power amplifier based on AlGaN/GaN HEMT

    Science.gov (United States)

    Zheng, Jia-Xin; Ma, Xiao-Hua; Lu, Yang; Zhao, Bo-Chao; Zhang, Hong-He; Zhang, Meng; Cao, Meng-Yi; Hao, Yue

    2015-10-01

    A C-band high efficiency and high gain two-stage power amplifier based on AlGaN/GaN high electron mobility transistor (HEMT) is designed and measured in this paper. The input and output impedances for the optimum power-added efficiency (PAE) are determined at the fundamental and 2nd harmonic frequency (f0 and 2f0). The harmonic manipulation networks are designed both in the driver stage and the power stage which manipulate the second harmonic to a very low level within the operating frequency band. Then the inter-stage matching network and the output power combining network are calculated to achieve a low insertion loss. So the PAE and the power gain is greatly improved. In an operation frequency range of 5.4 GHz-5.8 GHz in CW mode, the amplifier delivers a maximum output power of 18.62 W, with a PAE of 55.15% and an associated power gain of 28.7 dB, which is an outstanding performance. Project supported by the National Key Basic Research Program of China (Grant No. 2011CBA00606), Program for New Century Excellent Talents in University, China (Grant No. NCET-12-0915), and the National Natural Science Foundation of China (Grant No. 61334002).

  20. A C-band 55%PAE high gain two-stage power amplifier based on AlGaN/GaN HEMT

    Institute of Scientific and Technical Information of China (English)

    郑佳欣; 马晓华; 卢阳; 赵博超; 张宏鹤; 张濛; 曹梦逸; 郝跃

    2015-01-01

    A C-band high efficiency and high gain two-stage power amplifier based on AlGaN/GaN high electron mobility transistor (HEMT) is designed and measured in this paper. The input and output impedances for the optimum power-added efficiency (PAE) are determined at the fundamental and 2nd harmonic frequency ( f0 and 2 f0). The harmonic manipulation networks are designed both in the driver stage and the power stage which manipulate the second harmonic to a very low level within the operating frequency band. Then the inter-stage matching network and the output power combining network are calculated to achieve a low insertion loss. So the PAE and the power gain is greatly improved. In an operation frequency range of 5.4 GHz–5.8 GHz in CW mode, the amplifier delivers a maximum output power of 18.62 W, with a PAE of 55.15%and an associated power gain of 28.7 dB, which is an outstanding performance.

  1. Auto-digital gain balancing: a new detection scheme for high-speed chemical species tomography of minor constituents

    Science.gov (United States)

    Pal, Sandip; McCann, Hugh

    2011-11-01

    In many dynamic gas-phase reaction processes, there is great interest to measure the distribution of minor constituents, i.e. automotive gasoline engine exhaust by catalytic conversion, where a characteristic challenge is to image the distribution of 10 ppm (average) of carbon monoxide (CO) at 1000 frames per second across a 50 mm diameter exhaust pipe; this particular problem has been pursued as a case study. In this paper, we present a novel electronic scheme that achieves the required measurement of around 10-3 absorption with 10-4 precision at kHz bandwidth. This was not previously achievable with any known technology. We call the new scheme Auto-Digital Gain Balancing. It is amenable to replication for many simultaneous measurement channels, and it permits simultaneous measurement of multiple species, in some circumstances. Experimental demonstrations are presented in the near-infrared. In single scans of a tunable diode laser, measurements of both CO and CO2 have been made with 20 dB signal-to-noise ratio at peak absorption. This work paves the way for chemical species tomography of minor constituents in many dynamic gas-phase systems.

  2. Contradictions between the Virtual and Physical High School Classroom: A Third-Generation Activity Theory Perspective

    Science.gov (United States)

    Murphy, Elizabeth; Manzanares, Maria A. Rodriguez

    2008-01-01

    This paper uses a third-generation Activity Theory perspective to gain insight into the contradictions between the activity systems of the physical and virtual high school classroom from the perspective of teachers who had transitioned from one system to the other. Data collection relied on semi-structured interviews conducted with e-teachers as…

  3. Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice.

    Science.gov (United States)

    Iffiú-Soltész, Zsuzsa; Wanecq, Estelle; Lomba, Almudena; Portillo, Maria P; Pellati, Federica; Szöko, Eva; Bour, Sandy; Woodley, John; Milagro, Fermin I; Alfredo Martinez, J; Valet, Philippe; Carpéné, Christian

    2010-04-01

    Benzylamine is found in Moringa oleifera, a plant used to treat diabetes in traditional medicine. In mammals, benzylamine is metabolized by semicarbazide-sensitive amine oxidase (SSAO) to benzaldehyde and hydrogen peroxide. This latter product has insulin-mimicking action, and is involved in the effects of benzylamine on human adipocytes: stimulation of glucose transport and inhibition of lipolysis. This study examined whether chronic, oral administration of benzylamine could improve glucose tolerance and the circulating lipid profile without increasing oxidative stress in overweight and pre-diabetic mice. The benzylamine diffusion across the intestine was verified using everted gut sacs. Then, glucose handling and metabolic markers were measured in mice rendered insulin-resistant when fed a high-fat diet (HFD) and receiving or not benzylamine in their drinking water (3600micromol/(kgday)) for 17 weeks. HFD-benzylamine mice showed lower body weight gain, fasting blood glucose, total plasma cholesterol and hyperglycaemic response to glucose load when compared to HFD control. In adipocytes, insulin-induced activation of glucose transport and inhibition of lipolysis remained unchanged. In aorta, benzylamine treatment partially restored the nitrite levels that were reduced by HFD. In liver, lipid peroxidation markers were reduced. Resistin and uric acid, surrogate plasma markers of metabolic syndrome, were decreased. In spite of the putative deleterious nature of the hydrogen peroxide generated during amine oxidation, and in agreement with its in vitro insulin-like actions found on adipocytes, the SSAO-substrate benzylamine could be considered as a potential oral agent to treat metabolic syndrome.

  4. VHL-deficient renal cancer cells gain resistance to mitochondria-activating apoptosis inducers by activating AKT through the IGF1R-PI3K pathway.

    Science.gov (United States)

    Yamaguchi, Ryuji; Harada, Hiroshi; Hirota, Kiichi

    2016-10-01

    We previously developed (2-deoxyglucose)-(ABT-263) combination therapy (2DG-ABT), which induces apoptosis by activating Bak in the mitochondria of highly glycolytic cells with varied genetic backgrounds. However, the rates of apoptosis induced by 2DG-ABT were lower in von Hippel-Lindau (VHL)-deficient cancer cells. The re-expression of VHL protein in these cells lowered IGF1R expression in a manner independent of oxygen concentration. Lowering IGF1R expression via small interfering RNA (siRNA) sensitized the cells to 2DG-ABT, suggesting that IGF1R interfered with the activation of apoptosis by the mitochondria. To determine which of the two pathways activated by IGF1R, the Ras-ERK pathway or the PI3K-AKT pathway, was involved in the impairment of mitochondria activation, the cells were treated with a specific inhibitor of either PI3K or ERK, and 2DG-ABT was added to activate the mitochondria. The apoptotic rates resulting from 2DG-ABT treatment were higher in the cells treated with the PI3K inhibitor, while the rates remained approximately the same in the cells treated with the ERK inhibitor. In 2DG-ABT-sensitive cells, a 4-h 2DG treatment caused the dissociation of Mcl-1 from Bak, while ABT treatment alone caused the dissociation of Bcl-xL from Bak without substantially reducing Mcl-1 levels. In 2DG-ABT-resistant cells, Mcl-1 dissociated from Bak only when AKT activity was inhibited during the 4-h 2DG treatment. Thus, in VHL-deficient cells, IGF1R activated AKT and stabilized the Bak-Mcl-1 complex, thereby conferring cell resistance to apoptosis.

  5. Low-Cost and High-Gain SIW Circularly Polarized Circular-Horn-Loaded Antenna for Broadband Millimeter-Wave Applications

    Directory of Open Access Journals (Sweden)

    Ming Du

    2017-09-01

    Full Text Available A wideband, low-cost and high-gain circularly polarized (CP circular-horn-loaded antenna based on substrate integrated waveguide (SIW technology operating at Ka band is presented. The proposed antenna, which is built on a single-layer substrate, consists of five parts: a short-ended SIW, a centro-symmetric wide slot, an L-shaped probe, a circular horn and a transition from SIW to air-filled rectangular waveguide for measurement. The slot is etched on the upper ground of the SIW, while the L-shaped probe for generating CP wave is printed inside the slot and connected to the SIW. A circular horn is also loaded on the surface of the SIW slot for high gain. Then, the proposed antenna with a dimension of 45×45×24.16 mm3 was fabricated and measured. The measured results show that the antenna has a wide impedance matching bandwidth of 28.6% from 30 to 40 GHz for |S11| ≤10 dB and a wide axial ratio (AR bandwidth of 22.8% from 31.5 to 39.6 GHz for AR ≤ 3 dB. The measured maximum gain is 15.6 dBi at 36 GHz with slight fluctuations over the 30–40-GHz frequency range. This kind of antenna merits low cost and easy integration with common differential circuits at the same time.

  6. Minimization of the impact of a broad bandwidth high-gain nonlinear preamplifier to the amplified spontaneous emission pedestal of the Vulcan petawatt laser facility.

    Science.gov (United States)

    Musgrave, I O; Hernandez-Gomez, C; Canny, D; Collier, J; Heathcote, R

    2007-10-01

    To generate petawatt pulses using the Vulcan Nd:glass laser requires a broad bandwidth high-gain preamplifier. The preamplifier used is an optical parametric amplifier that provides a total gain of 10(8) in three amplification stages. We report on a detailed investigation of the effect of the Vulcan optical parametric chirped pulse amplification (OPCPA) preamplifier on contrast caused by the amplified spontaneous emission (ASE) pedestal that extends up to 2 ns before the arrival of the main pulse. The contrast after compression is improved to 4x10(8) of the intensity of the main pulse using near-field apertures between the stages of the OPCPA preamplifier. Further reduction of the level of the ASE pedestal can be achieved at the cost of a reduction in amplified bandwidth by solely phosphate glass amplification after initial preamplification rather than a mixed glass amplification scheme.

  7. Ultra-thin single-layer transparent geometrical phase gradient metasurface and its application to high-gain circularly-polarized lens antenna

    Science.gov (United States)

    Li, Tang-Jing; Liang, Jian-Gang; Li, Hai-Peng; Liu, Ya-Qiao

    2016-09-01

    A new method to design an ultra-thin high-gain circularly-polarized antenna system with high efficiency is proposed based on the geometrical phase gradient metasurface (GPGM). With an accuracy control of the transmission phase and also the high transmission amplitude, the GPGM is capable of manipulating an electromagnetic wave arbitrarily. A focusing transmission lens working at Ku band is well optimized with the F/D of 0.32. A good focusing effect is demonstrated clearly by theoretical calculation and electromagnetic simulation. For further application, an ultra-thin single-layer transmissive lens antenna based on the proposed focusing metasurface operating at 13 GHz is implemented and launched by an original patch antenna from the perspective of high integration, simple structure, and low cost. Numerical and experimental results coincide well, indicating the advantages of the antenna system, such as a high gain of 17.6 dB, the axis ratio better than 2 dB, a high aperture efficiency of 41%, and also a simple fabrication process based on the convenient print circuit board technology. The good performance of the proposed antenna indicates promising applications in portable communication systems. Project supported by the National Natural Science Foundation of China (Grant No. 61372034).

  8. More gain less pain: balance control learning shifts the activation patterns of leg and neck muscles and increases muscular parsimony.

    Science.gov (United States)

    Iodice, Pierpaolo; Cesinaro, Stefano; Romani, Gian Luca; Pezzulo, Giovanni

    2015-07-01

    Athletes such as skaters or surfers maintain their balance on very unstable platforms. Remarkably, the most skilled athletes seem to execute these feats almost effortlessly. However, the dynamics that lead to the acquisition of a defined and efficient postural strategy are incompletely known. To understand the posture reorganization process due to learning and expertise, we trained twelve participants in a demanding balance/posture maintenance task for 4 months and measured their muscular activity before and after a (predictable) disturbance cued by an auditory signal. The balance training determined significant delays in the latency of participants' muscular activity: from largely anticipatory muscular activity (prior to training) to a mixed anticipatory-compensatory control strategy (after training). After training, the onset of activation was delayed for all muscles, and the sequence of activation systematically reflected the muscle position in the body from top to bottom: neck/upper body muscles were recruited first and in an anticipatory fashion, whereas leg muscles were recruited after the disturbance onset, producing compensatory adjustments. The resulting control strategy includes a mixture of anticipatory and compensatory postural adjustments, with a systematic sequence of muscular activation reflecting the different demands of neck and leg muscles. Our results suggest that subjects learned the precise timing of the disturbance onset and used this information to deploy postural adjustments just-in-time and to transfer at least part of the control of posture from anticipatory to less-demanding feedback-based strategies. In turn, this strategy shift increases the cost-efficiency of muscular activity, which is a key signature of skilled performance.

  9. No evidence for a role of the peroxisome proliferator-activated receptor gamma (PPARG) and adiponectin (ADIPOQ) genes in antipsychotic-induced weight gain.

    Science.gov (United States)

    Brandl, Eva J; Tiwari, Arun K; Zai, Clement C; Chowdhury, Nabilah I; Lieberman, Jeffrey A; Meltzer, Herbert Y; Kennedy, James L; Müller, Daniel J

    2014-10-30

    Antipsychotics frequently cause changes in glucose metabolism followed by development of weight gain and/or diabetes. Recent findings from our group indicated an influence of glucose-related genes on this serious side effect. With this study, we aimed to extend previous research and performed a comprehensive study on the peroxisome proliferator-activated receptor gamma (PPARG) and the adiponectin (ADIPOQ) genes. In 216 schizophrenic patients receiving antipsychotics for up to 14 weeks, we investigated single-nucleotide polymorphisms in or near PPARG (N=24) and ADIPOQ (N=18). Statistical analysis was done using ANCOVA in SPSS. Haplotype analysis was performed in UNPHASED 3.1.4 and Haploview 4.2. None of the PPARG or ADIPOQ variants showed significant association with antipsychotic-induced weight gain in our combined sample or in a refined subsample of patients of European ancestry treated with clozapine or olanzapine after correction for multiple testing. Similarly, no haplotype association could withstand multiple test correction. Although we could not find a significant influence of ADIPOQ and PPARG on antipsychotic-induced weight gain, our comprehensive examination of these two genes contributes to understanding the biology of this serious side effect. More research on glucose metabolism genes is warranted to elucidate their role in metabolic changes during antipsychotic treatment.

  10. Peroxisome proliferator-activated receptor gamma (PPARG) Pro12Ala: lack of association with weight gain in psychiatric inpatients treated with olanzapine or clozapine.

    Science.gov (United States)

    Staeker, Julia; Leucht, Stefan; Steimer, Werner

    2012-04-01

    Weight gain is a common problem of treatment with atypical antipsychotics. However, the dimension of body weight change differs interindividually, and various genetic factors are considered to be associated with this effect. Peroxisome proliferator-activated receptor gamma (PPARG) Pro12Ala polymorphism and its reported relationship to type 2 diabetes susceptibility and body mass accumulation prompted us to investigate the impact of this single nucleotide polymorphism (SNP) on antipsychotic-induced changes of body weight and body mass index (BMI) in a naturalistic study design. Included were 138 olanzapine- and 32 clozapine-treated psychiatric inpatients whose demographic data, medical anamnesis, and drug treatment were assessed at admission to hospital and 4 weeks thereafter. The PPARG Pro12Ala SNP was determined with a validated real-time PCR assay. In contrast to previous investigations, we did not detect significant variations of weight gain among the different PPARG Pro12Ala genotypes. Our results suggest that the examined polymorphism appears to play a minor or no role in clinical practice concerning antipsychotic drug-induced weight gain.

  11. Image formation using stimulated raman scattering gain

    Science.gov (United States)

    Bespalov, V. G.; Makarov, E. A.; Stasel'ko, D. I.

    2016-07-01

    Theoretical analysis of the spatial, noise, and energy characteristics of an amplifier has been performed in the mode of spectral and time selection using subnanosecond stimulated Raman Scattering gain of weak echo signals in crystalline active media that are known for high (up to 10-1 cm/MW) gain coefficients. The possibility to reach high gain values has been demonstrated for weak signals from objects at acceptable angular sizes of the field of vision of an amplifier. To provide a signal-to-noise ratio that exceeds unity over the entire field of vision, the number of photons at the input to an amplifier that is required has to exceed the number of its resolution elements. Accurate determination of the possibilities of recording of weak echo signals and quality of images of targets that are obtained using amplifiers under stimulated Raman Scattering requires additional special experiments.

  12. The Positive Influence of Active Learning in a Lecture Hall: An Analysis of Normalised Gain Scores in Introductory Environmental Engineering

    Science.gov (United States)

    Kinoshita, Timothy J.; Knight, David B.; Gibbes, Badin

    2017-01-01

    Burgeoning college enrolments and insufficient funding to higher education have expanded the use of large lecture courses. As this trend continues, it is important to ensure that students can still learn in those challenging learning environments. Within education broadly and undergraduate engineering specifically, active learning pedagogies have…

  13. Designing Gain- and Loss-Framed Messages to Increase Physical Activity among University Students Living in two Different Cultures

    Directory of Open Access Journals (Sweden)

    Pelin Ozgur Polat

    2015-10-01

    The primary aim of this project is to gather information through using different methods and investigate the determinants of message persuasiveness in university students from the British and Turkish cultures in order to design effective physical activity messages leading intention, attitude and behaviour change. The results of the finalized studies showed the importance of using both qualitative and quantitative methods in message design process.

  14. Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC)

    NARCIS (Netherlands)

    Zheng, J.; Veerdonk, F.L. van de; Crossland, K.L.; Smeekens, S.P.; Chan, C.M.; Shehri, T. Al; Abinun, M.; Gennery, A.R.; Mann, J.; Lendrem, D.W.; Netea, M.G.; Rowan, A.D.; Lilic, D.

    2015-01-01

    Signal transducer and activator of transcription 3 (STAT3) triggered production of Th-17 cytokines mediates protective immunity against fungi. Mutations affecting the STAT3/interleukin 17 (IL-17) pathway cause selective susceptibility to fungal (Candida) infections, a hallmark of chronic mucocutaneo

  15. Remembering with gains and losses: effects of monetary reward and punishment on successful encoding activation of source memories.

    Science.gov (United States)

    Shigemune, Yayoi; Tsukiura, Takashi; Kambara, Toshimune; Kawashima, Ryuta

    2014-05-01

    The motivation of getting rewards or avoiding punishments reinforces learning behaviors. Although the neural mechanisms underlying the effect of rewards on episodic memory have been demonstrated, there is little evidence of the effect of punishments on this memory. Our functional magnetic resonance imaging (fMRI) study investigated the effects of monetary rewards and punishments on activation during the encoding of source memories. During encoding, participants memorized words (item) and locations of presented words (source) under 3 conditions (Reward, Punishment, and Control). During retrieval, participants retrieved item and source memories of the words and were rewarded or penalized according to their performance. Source memories encoded with rewards or punishments were remembered better than those without such encoding. fMRI data demonstrated that the ventral tegmental area and substantia nigra and nucleus accumbens activations reflected both the processes of reward and punishment, whereas insular activation increased as a linear function of punishment. Activation in the hippocampus and parahippocampal cortex predicted subsequent retrieval success of source memories. Additionally, correlations between these reward/punishment-related regions and the hippocampus were significant. The successful encoding of source memories could be enhanced by punishments and rewards, and interactions between reward/punishment-related regions and memory-related regions could contribute to memory enhancement by reward and/or punishment.

  16. Impact of Korean pine nut oil on weight gain and immune responses in high-fat diet-induced obese mice.

    Science.gov (United States)

    Park, Soyoung; Lim, Yeseo; Shin, Sunhye; Han, Sung Nim

    2013-10-01

    Korean pine nut oil (PNO) has been reported to have favorable effects on lipid metabolism and appetite control. We investigated whether PNO consumption could influence weight gain, and whether the PNO-induced effect would result in an improvement of immune function in high-fat diet (HFD)-induced obese mice. C57BL/6 mice were fed control diets with 10% energy fat from either PNO or soybean oil (SBO), or HFDs with 45% energy fat from 10% PNO or SBO and 35% lard, 20% PNO or SBO and 25% lard, or 30% PNO or SBO and 15% lard for 12 weeks. The proliferative responses of splenocytes upon stimulation with concanavalin A (Con A) or lipopolysaccharide (LPS), Con A-stimulated production of interleukin (IL)-2 and interferon (IFN)-γ, and LPS-stimulated production of IL-6, IL-1β, and prostaglandin E2 (PGE2) by splenocytes were determined. Consumption of HFDs containing PNO resulted in significantly less weight gain (17% less, P PNO consumption resulted in a higher production of IL-1β (P = 0.04). Replacement of SBO with PNO had no effect on the production of IL-2, IFN-γ, IL-6, or PGE2 in mice fed with either the control diets or HFDs. In conclusion, consumption of PNO reduced weight gain in mice fed with HFD, but this effect did not result in the overall improvement in immune responses.

  17. Significant progression of load on the musculoskeletal system with extremely high loads, with rapid weekly weight gains, using the Anatoly Gravitational System, in a 10-week training period

    Directory of Open Access Journals (Sweden)

    Burke DT

    2013-10-01

    Full Text Available David T Burke,1 David Tran,1 Di Cui,1 Daniel P Burke,2 Samir Al-Adawi,3 Atsu SS Dorvlo41Emory University Medical School, Atlanta, GA, USA; 2Georgia College and State University, GA, USA; 3Department of Behavioral Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman; 4Department of Mathematics and Statistics, College of Science, Sultan Qaboos University, Muscat, OmanAbstract: In an age of increasing numbers of lifestyle diseases and plasticity of longevity, exercise and weight training have been increasingly recognized as both preventing and mitigating the severity of many illnesses. This study was designed to determine whether significant weight-lifting gains could be realized through the Anatoly Gravitational System. Specifically, this study sought to determine whether this once-weekly weight-training system could result in significant weekly strength gains during a 10-week training period. A total of 50 participants, ranging in age from 17 to 67 years, completed at least 10 weekly 30-minute training sessions. The results suggest participants could, on average, double their weight-lifting capacity within 10 sessions. This preliminary study, which would require further scrutiny, suggests the Anatoly Gravitational System provides a rather unique opportunity to load the musculoskeletal system with extremely high loads, with rapid weekly weight gains, using only short weekly training sessions. More studies are warranted to scrutinize these findings.Keywords: Anatoly Gravitational System, weight training, musculoskeletal system

  18. Planning High-Risk High-Reward Activities.

    NARCIS (Netherlands)

    Casault, Sébastien

    2014-01-01

    This body of work addresses a gap in financial and economic theories related to assets that are typically associated with high uncertainty. Specifically, this thesis provides some foundational work towards a new way to quantify and explain how high-risk high-reward activities, such as exploration,

  19. High-fat-diet-induced weight gain ameliorates bone loss without exacerbating AβPP processing and cognition in female APP/PS1 mice

    Directory of Open Access Journals (Sweden)

    Yunhua ePeng

    2014-08-01

    Full Text Available Osteoporosis is negatively correlated with body mass, whereas both osteoporosis and weight loss occur at higher incidence during the progression of Alzheimer’s disease (AD than the age-matched non-dementia individuals. Given that there is no evidence that overweight associated with AD-type cognitive dysfunction, we hypothesized that moderate weight gain might have a protective effect on the bone loss in AD without exacerbating cognitive dysfunction. In the present study, feeding a high-fat-diet (HFD, 45% calorie from fat to female APP/PS1 transgenic mice, an AD animal model, induced weight gain. The bone mineral density, microarchitecture, and biomechanical properties of the femurs were then evaluated. The results showed that the middle-aged female APP/PS1 transgenic mice were susceptible to osteoporosis of the femoral bones and that weight gain significantly enhanced bone mass and mechanical properties. Notably, HFD was not detrimental to brain insulin signaling and AβPP processing, as well as to exploration ability and working, learning and memory performance of the transgenic mice measured by T maze and water maze, compared with the mice fed a normal fat diet (10% calorie from fat. In addition, the circulating levels of leptin but not estradiol were remarkably elevated in HFD-treated mice. These results suggest that a body weight gain induced by the HFD feeding regimen significantly improved bone mass in female APP/PS1 mice with no detriments to exploration ability and spatial memory, most likely via the action of elevated circulating leptin.

  20. Supercontinuum generation in a photonic crystal fiber pumped by a gain-switched high-power fiber laser

    DEFF Research Database (Denmark)

    Larsen, Casper; Skovgaard, Peter M. W.; Noordegraaf, Danny;

    2011-01-01

    Supercontinuum (SC) generation in nonlinear photonic crystal fibers (NLF) using continuous-wave (CW) fiber lasers for pumping has been studied before[1,2]. The advantages of CW-SC are high spectral smoothness, high spectral power density, simplicity of the system, and lower noise than the more...... common picosecond-pumped SC. The cost of these features is increased nonlinear fiber lengths due to less efficient nonlinear processes at the lower power levels. Especially, the generation of light in the visible wavelength range has been a challenge. This has previously been tackled by increasing...

  1. Caffeine prevents weight gain and cognitive impairment caused by a high-fat diet while elevating hippocampal BDNF

    OpenAIRE

    Moy, Gregory A.; McNay, Ewan C.

    2012-01-01

    Obesity, high-fat diets, and subsequent type 2 diabetes (T2DM) are associated with cognitive impairment. Moreover, T2DM increases the risk of Alzheimer’s disease (AD) and leads to abnormal elevation of brain beta-amyloid levels, one of the hallmarks of AD. The psychoactive alkaloid caffeine has been shown to have therapeutic potential in AD but the central impact of caffeine has not been well-studied in the context of a high-fat diet. Here we investigated the impact of caffeine administration...

  2. Three months of high-fructose feeding fails to induce excessive weight gain or leptin resistance in mice.

    Directory of Open Access Journals (Sweden)

    Erik J Tillman

    Full Text Available High-fructose diets have been implicated in obesity via impairment of leptin signaling in humans and rodents. We investigated whether fructose-induced leptin resistance in mice could be used to study the metabolic consequences of fructose consumption in humans, particularly in children and adolescents. Male C57Bl/6 mice were weaned to a randomly assigned diet: high fructose, high sucrose, high fat, or control (sugar-free, low-fat. Mice were maintained on their diets for at least 14 weeks. While fructose-fed mice regularly consumed more kcal and expended more energy, there was no difference in body weight compared to control by the end of the study. Additionally, after 14 weeks, both fructose-fed and control mice displayed similar leptin sensitivity. Fructose-feeding also did not change circulating glucose, triglycerides, or free fatty acids. Though fructose has been linked to obesity in several animal models, our data fail to support a role for fructose intake through food lasting 3 months in altering of body weight and leptin signaling in mice. The lack of impact of fructose in the food of growing mice on either body weight or leptin sensitivity over this time frame was surprising, and important information for researchers interested in fructose and body weight regulation.

  3. Insights into composition/structure/function relationships of Doxil® gained from "high-sensitivity" differential scanning calorimetry.

    Science.gov (United States)

    Wei, Xiaohui; Cohen, Rivka; Barenholz, Yechezkel

    2016-07-01

    Thermotropic behavior of Doxil® and its generic, Lipodox®, was characterized using "high-sensitivity" differential scanning calorimetry (DSC). This is the first report that two distinct endotherms were observed in Doxil and Lipodox upon heating. The first (Tm at 51±2°C) is broad and of low enthalpy, representing the membrane lipid phase transition, which occurs despite having high (38mole%) cholesterol. The second (Tm at ∼70°C) is narrow, representing melting of the intraliposomal doxorubicin-sulfate nanocrystals. The thermograms of Doxil and Lipodox are practically identical. The membrane phase transition is similar to that of drug-free nanoliposomes of the same size and lipid composition as Doxil, suggesting lack of significant drug-membrane interaction. The melting endotherm of the intraliposomal nanocrystals is 2.0-2.5-fold narrower than that of the crystals formed in a solution of 250mM ammonium sulfate and >60mg/ml doxorubicin. This suggests that nanovolume of liposomes improves doxorubicin-sulfate crystallinity. Moreover, both phase transitions are reversible in cycled DSC scanning (15-90-15°C). This indicates an unexpected "non-leaky" phospholipid phase transition and excellent physical and chemical stabilities of Doxil after short exposure to high temperature. Reducing mole% of cholesterol results in a "leaky" membrane phase transition of higher enthalpy. Namely, high mole% cholesterol is essential for the resistance to drug leakage during phase transition. Pegylated liposomal doxorubicin in which HSPC was replaced by DPPC shows the same non-leaky phase transition but at a lower temperature, indicating this type of phase transition is not unique to Doxil. The presence of DSPE-PEG2k increases the cooperativity of the phase transition. High-sensitivity DSC helps illuminate composition/structure/function relationships of Doxil, and is useful for the equivalence/similarity studies. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. A gain-coefficient switched Alexandrite laser

    NARCIS (Netherlands)

    Lee, Chris J.; Slot, van der Peter J.M.; Boller, Klaus-J.

    2013-01-01

    We report on a gain-coefficient switched Alexandrite laser. An electro-optic modulator is used to switch between high and low gain states by making use of the polarization dependent gain of Alexandrite. In gain-coefficient switched mode, the laser produces 85 ns pulses with a pulse energy of 240 mJ

  5. A gain-coefficient switched Alexandrite laser

    CERN Document Server

    Lee, Chris J; Boller, Klaus-J

    2012-01-01

    We report on a gain-coefficient switched Alexandrite laser. An electro-optic modulator is used to switch between high and low gain states by making use of the polarization dependent gain of Alexandrite. In gain-coefficient switched mode, the laser produces 85 ns pulses with a pulse energy of 240 mJ at a repetition rate of 5 Hz.

  6. Novel high-gain, improved-bandwidth, finned-ladder V-band Traveling-Wave Tube slow-wave circuit design

    Science.gov (United States)

    Kory, Carol L.; Wilson, Jeffrey D.

    1994-01-01

    The V-band frequency range of 59-64 GHz is a region of the millimeter-wave spectrum that has been designated for inter-satellite communications. As a first effort to develop a high-efficiency V-band Traveling-Wave Tube (TWT), variations on a ring-plane slow-wave circuit were computationally investigated to develop an alternative to the more conventional ferruled coupled-cavity circuit. The ring-plane circuit was chosen because of its high interaction impedance, large beam aperture, and excellent thermal dissipation properties. Despite these advantages, however, low bandwidth and high voltage requirements have, until now, prevented its acceptance outside the laboratory. In this paper, the three-dimensional electrodynamic simulation code MAFIA (solution of MAxwell's Equation by the Finite-Integration-Algorithm) is used to investigate methods of increasing the bandwidth and lowering the operating voltage of the ring-plane circuit. Calculations of frequency-phase dispersion, beam on-axis interaction impedance, attenuation and small-signal gain per wavelength were performed for various geometric variations and loading distributions of the ring-plane TWT slow-wave circuit. Based on the results of the variations, a circuit termed the finned-ladder TWT slow-wave circuit was designed and is compared here to the scaled prototype ring-plane and a conventional ferruled coupled-cavity TWT circuit over the V-band frequency range. The simulation results indicate that this circuit has a much higher gain, significantly wider bandwidth, and a much lower voltage requirement than the scaled ring-plane prototype circuit, while retaining its excellent thermal dissipation properties. The finned-ladder circuit has a much larger small-signal gain per wavelength than the ferruled coupled-cavity circuit, but with a moderate sacrifice in bandwidth.

  7. Calorie-restricted weight loss reverses high-fat diet-induced ghrelin resistance, which contributes to rebound weight gain in a ghrelin-dependent manner.

    Science.gov (United States)

    Briggs, Dana I; Lockie, Sarah H; Wu, Qunli; Lemus, Moyra B; Stark, Romana; Andrews, Zane B

    2013-02-01

    Twelve weeks of high-fat diet feeding causes ghrelin resistance in arcuate neuropeptide Y (NPY)/agouti-related protein (AgRP) neurons. In the current study, we investigated whether diet-induced weight loss could restore NPY/AgRP neuronal responsiveness to ghrelin and whether ghrelin mediates rebound weight gain after calorie-restricted (CR) weight loss. Diet-induced obese (DIO) mice were allocated to one of two dietary interventions until they reached the weight of age-matched lean controls. DIO mice received chow diet ad libitum or chow diet with 40% CR. Chow-fed and high-fat-fed mice served as controls. Both dietary interventions normalized body weight, glucose tolerance, and plasma insulin. We show that diet-induced weight loss with CR increases total plasma ghrelin, restores ghrelin sensitivity, and increases hypothalamic NPY and AgRP mRNA expression. We propose that long-term DIO creates a higher body weight set-point and that weight loss induced by CR, as seen in the high-fat CR group, provokes the brain to protect the new higher set-point. This adaptation to weight loss likely contributes to rebound weight gain by increasing peripheral ghrelin concentrations and restoring the function of ghrelin-responsive neuronal populations in the hypothalamic arcuate nucleus. Indeed, we also show that DIO ghrelin-knockout mice exhibit reduced body weight regain after CR weight loss compared with ghrelin wild-type mice, suggesting ghrelin mediates rebound weight gain after CR weight loss.

  8. Design of wideband high-gain circularly polarized Vivaldi antenna array%高增益宽带圆极化Vivaldi天线阵的设计

    Institute of Scientific and Technical Information of China (English)

    许唐红; 张弘; 王东; 朱海涛; 兰敏

    2013-01-01

    提出了一种由新型Vivaldi天线单元构成的2×2十字交叉圆极化天线阵.Vivaldi天线单元采用边缘渐变对拓的锯齿结构,提高了天线在4.7~7.0 GHz频带内的增益,其反射系数低于-10 dB的带宽为2.4~11.0 GHz,具有超宽带线极化特性.圆极化天线阵测量结果显示,在4.5~7.0 GHz频带范围内,其轴比均低于3 dB,且整个频带范围内增益达11~13 dBi.%A circularly polarized (CP) crossed antenna array with 2X2 elements based on a novel antipodal Vivaldi antenna is proposed. The Vivaldi antenna with tapering serrated structure at the edges, which is a ultra-wideband (UWB) linearly polarized antenna, has a high gain at 4. 7-7. 0 GHz, and a wide impedance bandwidth of 2. 4-11. 0 GHz when the reflection coefficient is smaller than -10 dB. The measured data of the antenna array show that the axial ratio is lower than 3 dB between 4. 5 GHz and 7. 0 GHz. A high antenna gain from 11 dBi to 13 dBi is also achieved at the whole bandwidth of the array. The proposed antenna element and array both own UWB and high-gain characteristics.

  9. CNS metabolism in high-risk drug abuse : Insights gained from (1)H-, (31)P-MRS and PET.

    Science.gov (United States)

    Bodea, S

    2017-07-10

    High-risk drug consumption is a matter of great concern for public health actors in industrialised countries. The latest trends show a market tendency towards diversification and increasing demand for high-purity synthetic drugs. While most consumers seek medical help after cannabis use, it is high-risk drugs like cocaine, heroin and amphetamines that account for most of the 1000 drug-related deaths that occur in Germany every year. This article presents the most prominent in vivo cerebral metabolic information in cocaine, heroin and methamphetamine users provided by MRI spectroscopy and PET imaging. We reviewed the literature reporting neuroimaging studies of in vivo metabolic data for methamphetamine, cocaine and heroin consumption published up to March 2017. The search was conducted using PubMed and a combination of the following key words: methamphetamine, cocaine, heroin, MR spectroscopy, PET. MRI and PET are indispensable tools in gauging brain metabolic response to illegal drug abuse. Future breakthroughs in this field will most likely come from the investigation of novel neurotransmitter systems in PET and imaging phosphorus and carbon metabolites in MRI.

  10. Repetition-rate-selectable high-speed optical gating in a VO{sub 2} thin film based on gain modulation of optical amplifier

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yong Wook; Kim, Bong Jun; Choi, Sung Youl; Chae, Byung Gyu; Kim, Hyun Tak [Electronics and Telecommunications Research Institute, Daejeon (Korea, Republic of); Lee, Yong Wook [Pukyong National University, Busan (Korea, Republic of); Seo, Gi Wan [University of Science and Technology, Daejeon (Korea, Republic of); Lee, Yong Wan [University of Minnesota, Minneapolis, MN (United States)

    2010-12-15

    In this research, we investigated the dependence of the saturation-induced gain modulation (SIGM) on the modulation frequency of the input signal in an erbium-doped fiber amplifier (EDFA). By finding and incorporating the modulation frequency invariance of the SIGM realizable within some frequency range, we demonstrated a repetition-rate-selectable high-speed optical gating in two-terminal electrical devices based on vanadium-dioxide thin films. In the implemented optical gating system, the repetition rate could be freely chosen as an arbitrary frequency between 0.27 and 10 kHz without any degradation of the gating speed and the signal-to-noise ratio.

  11. High-Resolution Three-Dimensional Structural Data Quantify the Impact of Photoinhibition on Long-Term Carbon Gain in Wheat Canopies in the Field.

    Science.gov (United States)

    Burgess, Alexandra J; Retkute, Renata; Pound, Michael P; Foulkes, John; Preston, Simon P; Jensen, Oliver E; Pridmore, Tony P; Murchie, Erik H

    2015-10-01

    Photoinhibition reduces photosynthetic productivity; however, it is difficult to quantify accurately in complex canopies partly because of a lack of high-resolution structural data on plant canopy architecture, which determines complex fluctuations of light in space and time. Here, we evaluate the effects of photoinhibition on long-term carbon gain (over 1 d) in three different wheat (Triticum aestivum) lines, which are architecturally diverse. We use a unique method for accurate digital three-dimensional reconstruction of canopies growing in the field. The reconstruction method captures unique architectural differences between lines, such as leaf angle, curvature, and leaf density, thus providing a sensitive method of evaluating the productivity of actual canopy structures that previously were difficult or impossible to obtain. We show that complex data on light distribution can be automatically obtained without conventional manual measurements. We use a mathematical model of photosynthesis parameterized by field data consisting of chlorophyll fluorescence, light response curves of carbon dioxide assimilation, and manual confirmation of canopy architecture and light attenuation. Model simulations show that photoinhibition alone can result in substantial reduction in carbon gain, but this is highly dependent on exact canopy architecture and the diurnal dynamics of photoinhibition. The use of such highly realistic canopy reconstructions also allows us to conclude that even a moderate change in leaf angle in upper layers of the wheat canopy led to a large increase in the number of leaves in a severely light-limited state. © 2015 American Society of Plant Biologists. All Rights Reserved.

  12. High Gain Lateral Semi-Insulating GaAs Photoconductive Switch Triggered by 1064 nm Laser Pulses

    Institute of Scientific and Technical Information of China (English)

    施卫; 张显斌; 李琦; 陈二柱; 赵卫

    2002-01-01

    We report on the experimental results of a lateral semi-insulating GaAs photoconductive switch, with a gap of 8mm between two electrodes, triggered by 1064nm laser pulses at a wavelength beyond the GaAs absorption edge. Both the linear and nonlinear modes of the switch were observed when it was triggered by light pulses with an energy of l.9mJ and a pulse width of 60ns, and operated at high voltages of 3 and 5kV. The results show that when the semi-insulating GaAs photoconductive switch operates under an electrical field of 4.37 k V/cm, it will enter into the linear mode first, and then the switch will undergo the nonlinear mode (lock-on) after a delay of about 20 - 100 ns. It is worth noticing that the delay time under high light energy is longer than that in the low optical energy. The non-intrinsic absorption mechanism is discussed. EL2 deep level defects and double-photon absorption in GaAs may play a key part in the absorption process.

  13. High effective silica fume alkali activator

    Indian Academy of Sciences (India)

    Vladimír Živica

    2004-04-01

    Growing demands on the engineering properties of cement based materials and the urgency to decrease unsuitable ecologic impact of Portland cement manufacturing represent significant motivation for the development of new cement corresponding to these aspects. One category represents prospective alkali activated cements. A significant factor influencing their properties is alkali activator used. In this paper we present a new high effective alkali activator prepared from silica fume and its effectiveness. According to the results obtained this activator seems to be more effective than currently used activators like natrium hydroxide, natrium carbonate, and water glass.

  14. High magnetic shear gain in a liquid sodium stable Couette flow experiment: a prelude to an α-Ω dynamo.

    Science.gov (United States)

    Colgate, Stirling A; Beckley, Howard; Si, Jiahe; Martinic, Joe; Westpfahl, David; Slutz, James; Westrom, Cebastian; Klein, Brianna; Schendel, Paul; Scharle, Cletus; McKinney, Travis; Ginanni, Rocky; Bentley, Ian; Mickey, Timothy; Ferrel, Regnar; Li, Hui; Pariev, Vladimir; Finn, John

    2011-04-29

    The Ω phase of the liquid sodium α-Ω dynamo experiment at New Mexico Institute of Mining and Technology in cooperation with Los Alamos National Laboratory has demonstrated a high toroidal field B(ϕ) that is ≃8×B(r), where B(r) is the radial component of an applied poloidal magnetic field. This enhanced toroidal field is produced by the rotational shear in stable Couette flow within liquid sodium at a magnetic Reynolds number Rm≃120. Small turbulence in stable Taylor-Couette flow is caused by Ekman flow at the end walls, which causes an estimated turbulence energy fraction of (δv/v)(2)∼10(-3).

  15. Species' habitat use inferred from environmental variables at multiple scales: How much we gain from high-resolution vegetation data?

    Science.gov (United States)

    Gastón, Aitor; Ciudad, Carlos; Mateo-Sánchez, María C.; García-Viñas, Juan I.; López-Leiva, César; Fernández-Landa, Alfredo; Marchamalo, Miguel; Cuevas, Jorge; de la Fuente, Begoña; Fortin, Marie-Josée; Saura, Santiago

    2017-03-01

    Spatial resolution of environmental data may influence the results of habitat selection models. As high-resolution data are usually expensive, an assessment of their contribution to the reliability of habitat models is of interest for both researchers and managers. We evaluated how vegetation cover datasets of different spatial resolutions influence the inferences and predictive power of multi-scale habitat selection models for the endangered brown bear populations in the Cantabrian Range (NW Spain). We quantified the relative performance of three types of datasets: (i) coarse resolution data from Corine Land Cover (minimum mapping unit of 25 ha), (ii) medium resolution data from the Forest Map of Spain (minimum mapping unit of 2.25 ha and information on forest canopy cover and tree species present in each polygon), and (iii) high-resolution Lidar data (about 0.5 points/m2) providing a much finer information on forest canopy cover and height. Despite all the models performed well (AUC > 0.80), the predictive ability of multi-scale models significantly increased with spatial resolution, particularly when other predictors of habitat suitability (e.g. human pressure) were not used to indirectly filter out areas with a more degraded vegetation cover. The addition of fine grain information on forest structure (LiDAR) led to a better understanding of landscape use and a more accurate spatial representation of habitat suitability, even for a species with large spatial requirements as the brown bear, which will result in the development of more effective measures to assist endangered species conservation.

  16. Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia.

    Directory of Open Access Journals (Sweden)

    Hanna Janke

    Full Text Available About 30% of patients with acute myeloid leukemia (AML harbour mutations of the receptor tyrosine kinase FLT3, mostly internal tandem duplications (ITD and point mutations of the second tyrosine kinase domain (TKD. It was the aim of this study to comprehensively analyze clinical and functional properties of various FLT3 mutants. In 672 normal karyotype AML patients FLT3-ITD, but not FLT3-TKD mutations were associated with a worse relapse free and overall survival in multivariate analysis. In paired diagnosis-relapse samples FLT3-ITD showed higher stability (70% compared to FLT3-TKD (30%. In vitro, FLT3-ITD induced a strong activating phenotype in Ba/F3 cells. In contrast, FLT3-TKD mutations and other point mutations--including two novel mutations--showed a weaker but clear gain-of-function phenotype with gradual increase in proliferation and protection from apoptosis. The pro-proliferative capacity of the investigated FLT3 mutants was associated with cell surface expression and tyrosine 591 phosphorylation of the FLT3 receptor. Western blot experiments revealed STAT5 activation only in FLT3-ITD positive cell lines, in contrast to FLT3-non-ITD mutants, which displayed an enhanced signal of AKT and MAPK activation. Gene expression analysis revealed distinct difference between FLT3-ITD and FLT3-TKD for STAT5 target gene expression as well as deregulation of SOCS2, ENPP2, PRUNE2 and ART3. FLT3-ITD and FLT3 point mutations show a gain-of-function phenotype with distinct signalling properties in vitro. Although poor prognosis in AML is only associated with FLT3-ITD, all activating FLT3 mutations can contribute to leukemogenesis and are thus potential targets for therapeutic interventions.

  17. Co-regulation analysis of closely linked genes identifies a highly recurrent gain on chromosome 17q25.3 in prostate cancer

    Directory of Open Access Journals (Sweden)

    Martínez-A Carlos

    2008-10-01

    Full Text Available Abstract Background Transcriptional profiling of prostate cancer (PC has unveiled new markers of neoplasia and allowed insights into mechanisms underlying this disease. Genomewide analyses have also identified new chromosomal abnormalities associated with PC. The combination of both classes of data for the same sample cohort might provide better criteria for identifying relevant factors involved in neoplasia. Here we describe transcriptional signatures identifying distinct normal and tumoral prostate tissue compartments, and the inference and demonstration of a new, highly recurrent copy number gain on chromosome 17q25.3. Methods We have applied transcriptional profiling to tumoral and non-tumoral prostate samples with relatively homogeneous epithelial representations as well as pure stromal tissue from peripheral prostate and cultured cell lines, followed by quantitative RT-PCR validations and immunohistochemical analysis. In addition, we have performed in silico colocalization analysis of co-regulated genes and validation by fluorescent in situ hybridization (FISH. Results The transcriptomic analysis has allowed us to identify signatures corresponding to non-tumoral luminal and tumoral epithelium, basal epithelial cells, and prostate stromal tissue. In addition, in silico analysis of co-regulated expression of physically linked genes has allowed us to predict the occurrence of a copy number gain at chromosomal region 17q25.3. This computational inference was validated by fluorescent in situ hybridization, which showed gains in this region in over 65% of primary and metastatic tumoral samples. Conclusion Our approach permits to directly link gene copy number variations with transcript co-regulation in association with neoplastic states. Therefore, transcriptomic studies of carefully selected samples can unveil new diagnostic markers and transcriptional signatures highly specific of PC, and lead to the discovery of novel genomic abnormalities

  18. Experimental studies of high order soliton compression effect and gain characteristics in femtosecond laser pulses Er3+-doped fiber amplifier

    Institute of Scientific and Technical Information of China (English)

    刘东峰; 陈国夫; 白晋涛; 王贤华

    2000-01-01

    Seed laser pulses with average power of 146 pW and pulse duration of 480 fs were amplified to 14.5 mW. The pulse duration was compressed to 260 fs using 6 m high concentration Er3+ -doped fiber under forward pumping. The amplified signal pulse energy was 0.691 nJ (corresponding to a peak power of 2 657.7 W) and the repetition rate was 20.84 MHz. Spectrum breakup was observed simultaneously. The spectrum of pulses amplified by 3 m Er3+ -doped fiber remains a single peak under different pump power. The amplified pulse duration was compressed abnormally with the increasing pump power using the backward pumping; that is, the amplified pulses were compressed with the increasing pump power under low pump power. When the pump power reached 38 mW, the shortest amplified pulse duration was 309 fs. With further increase in pump power, the amplified pulses began broadening, accompanied by a single peak spectrum under different pump power.

  19. Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity.

    Directory of Open Access Journals (Sweden)

    Christian C Evans

    Full Text Available Diet-induced obesity (DIO is a significant health concern which has been linked to structural and functional changes in the gut microbiota. Exercise (Ex is effective in preventing obesity, but whether Ex alters the gut microbiota during development with high fat (HF feeding is unknown.Determine the effects of voluntary Ex on the gastrointestinal microbiota in LF-fed mice and in HF-DIO.Male C57BL/6 littermates (5 weeks were distributed equally into 4 groups: low fat (LF sedentary (Sed LF/Sed, LF/Ex, HF/Sed and HF/Ex. Mice were individually housed and LF/Ex and HF/Ex cages were equipped with a wheel and odometer to record Ex. Fecal samples were collected at baseline, 6 weeks and 12 weeks and used for bacterial DNA isolation. DNA was subjected both to quantitative PCR using primers specific to the 16S rRNA encoding genes for Bacteroidetes and Firmicutes and to sequencing for lower taxonomic identification using the Illumina MiSeq platform. Data were analyzed using a one or two-way ANOVA or Pearson correlation.HF diet resulted in significantly greater body weight and adiposity as well as decreased glucose tolerance that were prevented by voluntary Ex (p<0.05. Visualization of Unifrac distance data with principal coordinates analysis indicated clustering by both diet and Ex at week 12. Sequencing demonstrated Ex-induced changes in the percentage of major bacterial phyla at 12 weeks. A correlation between total Ex distance and the ΔCt Bacteroidetes: ΔCt Firmicutes ratio from qPCR demonstrated a significant inverse correlation (r2 = 0.35, p = 0.043.Ex induces a unique shift in the gut microbiota that is different from dietary effects. Microbiota changes may play a role in Ex prevention of HF-DIO.

  20. Exercise Prevents Weight Gain and Alters the Gut Microbiota in a Mouse Model of High Fat Diet-Induced Obesity

    Science.gov (United States)

    Evans, Christian C.; LePard, Kathy J.; Kwak, Jeff W.; Stancukas, Mary C.; Laskowski, Samantha; Dougherty, Joseph; Moulton, Laura; Glawe, Adam; Wang, Yunwei; Leone, Vanessa; Antonopoulos, Dionysios A.; Smith, Dan; Chang, Eugene B.; Ciancio, Mae J.

    2014-01-01

    Background Diet-induced obesity (DIO) is a significant health concern which has been linked to structural and functional changes in the gut microbiota. Exercise (Ex) is effective in preventing obesity, but whether Ex alters the gut microbiota during development with high fat (HF) feeding is unknown. Objective Determine the effects of voluntary Ex on the gastrointestinal microbiota in LF-fed mice and in HF-DIO. Methods Male C57BL/6 littermates (5 weeks) were distributed equally into 4 groups: low fat (LF) sedentary (Sed) LF/Sed, LF/Ex, HF/Sed and HF/Ex. Mice were individually housed and LF/Ex and HF/Ex cages were equipped with a wheel and odometer to record Ex. Fecal samples were collected at baseline, 6 weeks and 12 weeks and used for bacterial DNA isolation. DNA was subjected both to quantitative PCR using primers specific to the 16S rRNA encoding genes for Bacteroidetes and Firmicutes and to sequencing for lower taxonomic identification using the Illumina MiSeq platform. Data were analyzed using a one or two-way ANOVA or Pearson correlation. Results HF diet resulted in significantly greater body weight and adiposity as well as decreased glucose tolerance that were prevented by voluntary Ex (p<0.05). Visualization of Unifrac distance data with principal coordinates analysis indicated clustering by both diet and Ex at week 12. Sequencing demonstrated Ex-induced changes in the percentage of major bacterial phyla at 12 weeks. A correlation between total Ex distance and the ΔCt Bacteroidetes: ΔCt Firmicutes ratio from qPCR demonstrated a significant inverse correlation (r2 = 0.35, p = 0.043). Conclusion Ex induces a unique shift in the gut microbiota that is different from dietary effects. Microbiota changes may play a role in Ex prevention of HF-DIO. PMID:24670791

  1. Gut microbiota Modulated by Probiotics and Garcinia cambogia Extract Correlate with Weight Gain and Adipocyte Sizes in High Fat-Fed Mice.

    Science.gov (United States)

    Heo, Jaeyoung; Seo, Minseok; Park, Hwanhee; Lee, Woon Kyu; Guan, Le Luo; Yoon, Joon; Caetano-Anolles, Kelsey; Ahn, Hyeonju; Kim, Se-Young; Kang, Yoon-Mo; Cho, Seoae; Kim, Heebal

    2016-09-23

    Results of recent studies on gut microbiota have suggested that obesogenic bacteria exacerbate obesity and metabolic dysfunction in the host when fed a high fat diet (HFD). In order to explore obesity-associated bacterial candidates and their response to diet, the composition of faecal bacterial communities was investigated by analyzing 16S rRNA gene sequences in mice. Dietary intervention with probiotics and Garcinia cambogia extract attenuated weight gain and adipocyte size in HFD-fed mice. To identify obesity-causative microbiota, two statistical analyses were performed. Forty-eight bacterial species were found to overlap between the two analyses, indicating the commonly identified species as diet-driven and obesity-associated, which would make them strong candidates for host-microbiome interaction on obesity. Finally, correlation based network analysis between diet, microbe, and host revealed that Clostridium aminophilum, a hyper-ammonia-producing bacterium, was highly correlated with obesity phenotypes and other associated bacteria, and shown to be suppressed by the combination of probiotics and Garcinia cambogia extract. Results of the present study suggest that probiotics and Garcinia cambogia extract alleviate weight gain and adiposity, in part via differentially modulating the composition of gut microbiota in HFD fed mice.

  2. Gut microbiota Modulated by Probiotics and Garcinia cambogia Extract Correlate with Weight Gain and Adipocyte Sizes in High Fat-Fed Mice

    Science.gov (United States)

    Heo, Jaeyoung; Seo, Minseok; Park, Hwanhee; Lee, Woon Kyu; Guan, Le Luo; Yoon, Joon; Caetano-Anolles, Kelsey; Ahn, Hyeonju; Kim, Se-Young; Kang, Yoon-Mo; Cho, Seoae; Kim, Heebal

    2016-01-01

    Results of recent studies on gut microbiota have suggested that obesogenic bacteria exacerbate obesity and metabolic dysfunction in the host when fed a high fat diet (HFD). In order to explore obesity-associated bacterial candidates and their response to diet, the composition of faecal bacterial communities was investigated by analyzing 16S rRNA gene sequences in mice. Dietary intervention with probiotics and Garcinia cambogia extract attenuated weight gain and adipocyte size in HFD-fed mice. To identify obesity-causative microbiota, two statistical analyses were performed. Forty-eight bacterial species were found to overlap between the two analyses, indicating the commonly identified species as diet-driven and obesity-associated, which would make them strong candidates for host-microbiome interaction on obesity. Finally, correlation based network analysis between diet, microbe, and host revealed that Clostridium aminophilum, a hyper-ammonia-producing bacterium, was highly correlated with obesity phenotypes and other associated bacteria, and shown to be suppressed by the combination of probiotics and Garcinia cambogia extract. Results of the present study suggest that probiotics and Garcinia cambogia extract alleviate weight gain and adiposity, in part via differentially modulating the composition of gut microbiota in HFD fed mice. PMID:27658722

  3. A High-Gain Three-Port Power Converter with Fuel Cell, Battery Sources and Stacked Output for Hybrid Electric Vehicles and DC-Microgrids

    Directory of Open Access Journals (Sweden)

    Ching-Ming Lai

    2016-03-01

    Full Text Available This paper proposes a novel high-gain three-port power converter with fuel cell (FC, battery sources and stacked output for a hybrid electric vehicle (HEV connected to a dc-microgrid. In the proposed power converter, the load power can be flexibly distributed between the input sources. Moreover, the charging or discharging of the battery storage device can be controlled effectively using the FC source. The proposed converter has several outputs in series to achieve a high-voltage output, which makes it suitable for interfacing with the HEV and dc-microgrid. On the basis of the charging and discharging states of the battery storage device, two power operation modes are defined. The proposed power converter comprises only one boost inductor integrated with a flyback transformer; the boost and flyback circuit output terminals are stacked to increase the output voltage gain and reduce the voltage stress on the power devices. This paper presents the circuit configuration, operating principle, and steady-state analysis of the proposed converter, and experiments conducted on a laboratory prototype are presented to verify its effectiveness.

  4. New insights into nitrate dynamics in a karst groundwater system gained from in situ high-frequency optical sensor measurements

    Science.gov (United States)

    Opsahl, S. P.; Musgrove, M.; Slattery, R. N.

    2017-03-01

    Understanding nitrate dynamics in groundwater systems as a function of climatic conditions, especially during contrasting patterns of drought and wet cycles, is limited by a lack of temporal and spatial data. Nitrate sensors have the capability for making accurate, high-frequency measurements of nitrate in situ, but have not yet been evaluated for long-term use in groundwater wells. We measured in situ nitrate continuously in two groundwater monitoring wells -one rural and one urban-located in the recharge zone of a productive karst aquifer in central Texas in order to resolve changes that occur over both short-term (hourly to daily) and long-term (monthly to yearly) periods. Nitrate concentrations, measured as nitrate-nitrogen in milligrams per liter (mg/L), during drought conditions showed little or no temporal change as groundwater levels declined. During aquifer recharge, extremely rapid changes in concentration occurred at both wells as documented by hourly data. At both sites, nitrate concentrations were affected by recharging surface water as evidenced by nitrate concentrations in groundwater recharge (0.8-1.3 mg/L) that were similar to previously reported values for regional recharging streams. Groundwater nitrate concentrations responded differently at urban and rural sites during groundwater recharge. Concentrations at the rural well (approximately 1.0 mg/L) increased as a result of higher nitrate concentrations in groundwater recharge relative to ambient nitrate concentrations in groundwater, whereas concentrations at the urban well (approximately 2.7 mg/L) decreased as a result of the dilution of higher ambient nitrate concentrations relative to those in groundwater recharge. Notably, nitrate concentrations decreased to as low as 0.8 mg/L at the urban site during recharge but postrecharge concentrations exceeded 3.0 mg/L. A return to higher nitrate concentrations postrecharge indicates mobilization of a localized source of elevated nitrate within the

  5. Multipolar, time-dynamical model for the loss compensation and lasing of a spherical plasmonic nanoparticle spaser immersed in an active gain medium

    Science.gov (United States)

    Veltri, Alessandro; Chipouline, Arkadi; Aradian, Ashod

    2016-09-01

    The plasmonic response of a metal nanoparticle in the presence of surrounding gain elements is studied, using a space and time-dependent model, which integrates a quantum formalism to describe the gain and a classical treatment for the metal. Our model fully takes into account the influence of the system geometry (nanosphere) and offers for the first time, the possibility to describe the temporal evolution of the fields and the coupling among the multipolar modes of the particle. We calculate the lasing threshold value for all multipoles of the spaser, and demonstrate that the dipolar one is lowest. The onset of the lasing instability, in the linear regime, is then studied both with and without external field forcing. We also study the behaviour of the system below the lasing threshold, with the external field, demonstrating the existence of an amplification regime where the nanoparticle’s plasmon is strongly enhanced as the threshold is approached. Finally, a qualitative discussion is provided on later, non-linear stages of the dynamics and the approach to the steady-state of the spaser; in particular, it is shown that, for the considered geometry, the spasing is necessarily multi-modal and multipolar modes are always activated.

  6. A flexible and high-performance bidirectional optical amplifier with all optical gain control using ASE noise path through multi-port circulators

    Institute of Scientific and Technical Information of China (English)

    An Vu Tran; Chang-Joon Chae; Rodney S. Tucker

    2003-01-01

    We report a flexible all-optical gain controlled bidirectional optical amplifier. The device achieves constant gain and low noise figure over a large input power range. Moreover, the device removes Rayleigh backscattered light and amplifier noise.

  7. Effects on weight gain and gut microbiota in rats given bacterial supplements and a high-energy-dense diet from fetal life through to 6 months of age.

    Science.gov (United States)

    Karlsson, Caroline L J; Molin, Göran; Fåk, Frida; Johansson Hagslätt, Marie-Louise; Jakesevic, Maja; Håkansson, Åsa; Jeppsson, Bengt; Weström, Björn; Ahrné, Siv

    2011-09-01

    The aim of the present study was to assess the long-term effects of a high-energy-dense diet, supplemented with Lactobacillus plantarum (Lp) or Escherichia coli (Ec), on weight gain, fattening and the gut microbiota in rats. Since the mother's dietary habits can influence offspring physiology, dietary regimens started with the dams at pregnancy and throughout lactation and continued with the offspring for 6 months. The weight gain of group Lp was lower than that of groups C (control) and Ec (P = 0·086). More retroperitoneal adipose tissue (P = 0·030) and higher plasma leptin (P = 0·035) were observed in group Ec compared with group Lp. The viable count of Enterobacteriaceae was higher in group Ec than in group Lp (P = 0·019), and when all animals were compared, Enterobacteriaceae correlated positively with body weight (r 0·428, P = 0·029). Bacterial diversity was lower in group Ec than in groups C (P ≤ 0·05) and Lp (P ≤ 0·05). Firmicutes, Bacteroidetes and Verrucomicrobia dominated in all groups, but Bacteroidetes were more prevalent in group C than in groups Lp (P = 0·036) and Ec (P = 0·056). The same five bacterial families dominated the microbiota of groups Ec and C, and four of these were also present in group Lp. The other five families dominating in group Lp were not found in any of the other groups. Multivariate data analysis pointed in the same directions as the univariate statistics. The present results suggest that supplementation of L. plantarum or E. coli can have long-term effects on the composition of the intestinal microbiota, as well as on weight gain and fattening.

  8. Challenges for the Adaptive Gain Integrating Pixel Detector (AGIPD) design due to the high intensity photon radiation environment at the European XFEL

    CERN Document Server

    Becker, J; Göttlicher, P; Graafsma, H; Hirsemann, H; Jack, S; Klyuev, A; Marras, S Lange A; Trunk, U; Klanner, R; Schwandt, J; Zhang, J; Dinapoli, R; Greiffenberg, D; Henrich, B; Mozzanica, A; Schmitt, B; Shi, X; Gronewald, M; Krüger, H

    2013-01-01

    The European X-ray Free Electron Laser (XFEL) is a new research facility currently under construction in Hamburg, Germany. With a pulse length of less than 100 fs and an extremely high luminosity of 27000 flashes per second the European XFEL will have a unique time structure that demands the development of new detectors tailored to the requirements imposed by the experiments while complying with the machine specific operation parameters. The Adaptive Gain Integrating Pixel Detector (AGIPD) is one response to the need for large 2D detectors, able to cope with the 4.5 MHz frame rate, as well as with the high dynamic range needed by XFEL experiments ranging from single photons to more than 10$^4$ 12 keV photons per pixel per pulse. In addition it has to withstand doses of up to 1 GGy over three years.

  9. Whey-reduced weight gain is associated with a temporary growth reduction in young mice fed a high-fat diet

    DEFF Research Database (Denmark)

    Tranberg, Britt; Madsen, Andreas N.; Hansen, Axel K.;

    2015-01-01

    Whey protein consumption reportedly alleviates parameters of the metabolic syndrome. Here, we investigated the effects of whey protein isolate (whey) in young mice fed a high-fat diet. We hypothesized that whey as the sole protein source reduced early weight gain associated with retarded growth...... and decreased concentration of insulin-like growth factor-1. Moreover, we hypothesized that these changes were explained by increased nitrogen loss via elevated urea production and/or increased energy expenditure. Male 5-week-old C57BL/6 mice were fed high-fat diets with the protein source being either whey......, casein or a combination of both for 5 weeks. After 1, 3 or 5 weeks, respectively, the mice were subjected to a meal challenge with measurements of blood and urinary urea before and 1 and 3 h after eating a weighed meal of their respective diets. In a subset of mice, energy expenditure was measured...

  10. The Study of Electromagnetic Wave Propogation in Photonic Crystals Via Planewave Based Transfer (Scattering) Matrix Method with Active Gain Material Applications

    Energy Technology Data Exchange (ETDEWEB)

    LI, Ming [Iowa State Univ., Ames, IA (United States)

    2007-01-01

    In this dissertation, a set of numerical simulation tools are developed under previous work to efficiently and accurately study one-dimensional (1D), two-dimensional(2D), 2D slab and three-dimensional (3D) photonic crystal structures and their defects effects by means of spectrum (transmission, reflection, absorption), band structure (dispersion relation), and electric and/or magnetic fields distribution (mode profiles). Furthermore, the lasing property and spontaneous emission behaviors are studied when active gain materials are presented in the photonic crystal structures. Various physical properties such as resonant cavity quality factor, waveguide loss, propagation group velocity of electromagnetic wave and light-current curve (for lasing devices) can be obtained from the developed software package.

  11. Tailoring Directive Gain for High-Contrast, Wide-Viewing-Angle Organic Light-Emitting Diodes Using Speckle Image Holograpy Metasurfaces.

    Science.gov (United States)

    Zhou, Lei; Ou, Qing-Dong; Shen, Su; Zhou, Yun; Fan, Yuan-Yuan; Zhang, Jun; Tang, Jian-Xin

    2016-08-31

    Holography metasurfaces have been used to control the propagation of light to an unprecedented level, exhibiting the immense potential for light steering in organic light-emitting diodes (OLEDs). Here, a new approach to tailoring directive gain for high contrast, wide-viewing-angle OLEDs is proposed by implementing a spcekle image holography (SIH) metasurface. The experimental and theoretical results provide the direct proofs that the SIH metasurface can play very important roles not only in releasing the trapped energy flow insides the devices but also in tailoring the wavefronts to the preferred patterns due to its "regional orientation" k-vectors patterns. The resulting power efficiency and external quantum efficiency of the OLEDs using a SIH metasurface are 1.97 and 1.95 times that of the reference device with a standard architecture. Furthermore, the wavefronts of emitted light are delicately modulated in a polarization-independent manner, yielding 2.5 times higher contrast ratio compared to the reference device. This unique engineered directive gain property is also well-retained for the viewing angles varing from normal to titled ±60° without spectral distortion. These results enrich the understanding of light wavefronts control in OLEDs and highlight its potential application in display as well as light steering for other optoelectronics.

  12. Lower weight gain and hepatic lipid content in hamsters fed high fat diets supplemented with white rice protein, brown rice protein, soy protein, and their hydrolysates.

    Science.gov (United States)

    Zhang, Huijuan; Bartley, Glenn E; Mitchell, Cheryl R; Zhang, Hui; Yokoyama, Wallace

    2011-10-26

    The physiological effects of the hydrolysates of white rice protein (WRP), brown rice protein (BRP), and soy protein (SP) hydrolyzed by the food grade enzyme, alcalase2.4 L, were compared to the original protein source. Male Syrian Golden hamsters were fed high-fat diets containing either 20% casein (control) or 20% extracted proteins or their hydrolysates as the protein source for 3 weeks. The brown rice protein hydrolysate (BRPH) diet group reduced weight gain 76% compared with the control. Animals fed the BRPH supplemented diet also had lower final body weight, liver weight, very low density lipoprotein cholesterol (VLDL-C), and liver cholesterol, and higher fecal fat and bile acid excretion than the control. Expression levels of hepatic genes for lipid oxidation, PPARα, ACOX1, and CPT1, were highest for hamsters fed the BRPH supplemented diet. Expression of CYP7A1, the gene regulating bile acid synthesis, was higher in all test groups. Expression of CYP51, a gene coding for an enzyme involved in cholesterol synthesis, was highest in the BRPH diet group. The results suggest that BRPH includes unique peptides that reduce weight gain and hepatic cholesterol synthesis.

  13. Four-Week Consumption of Malaysian Honey Reduces Excess Weight Gain and Improves Obesity-Related Parameters in High Fat Diet Induced Obese Rats

    Directory of Open Access Journals (Sweden)

    Suhana Samat

    2017-01-01

    Full Text Available Many studies revealed the potential of honey consumption in controlling obesity. However, no study has been conducted using Malaysian honey. In this study, we investigated the efficacy of two local Malaysian honey types: Gelam and Acacia honey in reducing excess weight gain and other parameters related to obesity. The quality of both honey types was determined through physicochemical analysis and contents of phenolic and flavonoid. Male Sprague-Dawley rats were induced to become obese using high fat diet (HFD prior to introduction with/without honey or orlistat for four weeks. Significant reductions in excess weight gain and adiposity index were observed in rats fed with Gelam honey compared to HFD rats. Moreover, levels of plasma glucose, triglycerides, and cholesterol, plasma leptin and resistin, liver enzymes, renal function test, and relative organ weight in Gelam and Acacia honey treated groups were reduced significantly when compared to rats fed with HFD only. Similar results were also displayed in rats treated with orlistat, but with hepatotoxicity effects. In conclusion, consumption of honey can be used to control obesity by regulating lipid metabolism and appears to be more effective than orlistat.

  14. Asthma Triggers: Gain Control

    Science.gov (United States)

    ... Search Asthma Contact Us Share Asthma Triggers: Gain Control Breathing Freely: Controlling Asthma Triggers This video features ... Air Quality: Biological Pollutants Help Your Child Gain Control Over Asthma Top of Page Molds About Molds ...

  15. Enclosure for handling high activity materials

    Energy Technology Data Exchange (ETDEWEB)

    Jimeno de Osso, F.

    1977-07-01

    One of the most important problems that are met at the laboratories producing and handling radioisotopes is that of designing, building and operating enclosures suitable for the safe handling of active substances. With this purpose in mind, an enclosure has been designed and built for handling moderately high activities under a shielding made of 150 mm thick lead. In this report a description is given of those aspects that may be of interest to people working in this field. (Author)

  16. Generating Isolated Terawatt-Attosecond X-ray Pulses via a Chirped Laser Enhanced High-Gain Free-electron Laser

    CERN Document Server

    Wang, Zhen; Zhao, Zhentang

    2016-01-01

    A feasible method is proposed to generate isolated attosecond terawatt x-ray radiation pulses in high-gain free-electron lasers. In the proposed scheme, a frequency chirped laser pulse is employed to generate a gradually-varied spacing current enhancement of the electron beam and a series of spatiotemporal shifters are applied between the undulator sections to amplify a chosen ultra-short radiation pulse from self-amplified spontaneous emission. Three-dimensional start-to-end simulations have been carried out and the calculation results demonstrated that 0.15 nm x-ray pulses with peak power over 1TW and duration of several tens of attoseconds could be achieved by using the proposed technique.

  17. Wideband and high-gain frequency stabilization of a 100-W injection-locked Nd:YAG laser for second-generation gravitational wave detectors

    Science.gov (United States)

    Ohmae, Noriaki; Moriwaki, Shigenori; Mio, Norikatsu

    2010-07-01

    Second-generation gravitational wave detectors require a highly stable laser with an output power greater than 100 W to attain their target sensitivity. We have developed a frequency stabilization system for a 100-W injection-locked Nd:YAG (yttrium aluminum garnet) laser. By placing an external wideband electro-optic modulator used as a fast-frequency actuator in the optical path of the slave output, we can circumvent a phase delay in the frequency control loop originating from the pole of an injection-locked slave cavity. Thus, we have developed an electro-optic modulator made of a MgO-doped stoichiometric LiNbO3 crystal. Using this modulator, we achieve a frequency control bandwidth of 800 kHz and a control gain of 180 dB at 1 kHz. These values satisfy the requirement for a laser frequency control loop in second-generation gravitational wave detectors.

  18. Laser diode structures with a saturable absorber for high-energy picosecond optical pulse generation by combined gain-and Q-switching

    Science.gov (United States)

    Ryvkin, B. S.; Avrutin, E. A.; Kostamovaara, J. E. K.; Kostamovaara, J. T.

    2017-02-01

    The performance of gain-switched Fabry-Perot asymmetric-waveguide semiconductor lasers with a large equivalent spot size and an intracavity saturable absorber was investigated experimentally and theoretically. The laser with a short (˜20 μm) absorber emitted high-energy afterpulse-free optical pulses in a broad range of injection current pulse amplitudes; optical pulses with a peak power of about 35 W and a duration of about 80 ps at half maximum were achieved with a current pulse with an amplitude of just 8 A and a duration of 1.5 ns. Good quality pulsations were observed in a broad range of elevated temperatures. The introduction of a substantially longer absorber section leads to strong spectral broadening of the output without a significant improvement to pulse energy and peak power.

  19. Generating isolated terawatt-attosecond x-ray pulses via a chirped-laser-enhanced high-gain free-electron laser

    Directory of Open Access Journals (Sweden)

    Zhen Wang

    2017-04-01

    Full Text Available A feasible method is proposed to generate isolated attosecond terawatt x-ray radiation pulses in high-gain free-electron lasers. In the proposed scheme, a frequency chirped laser pulse is employed to generate a gradually varied spacing current enhancement of the electron beam, and a series of spatiotemporal shifters are applied between the undulator sections to amplify a chosen ultrashort radiation pulse from self-amplified spontaneous emission. Three-dimensional start-to-end simulations have been carried out, and the calculation results demonstrated that 0.15 nm x-ray pulses with a peak power over 1 TW and a duration of several tens of attoseconds could be achieved by using the proposed technique.

  20. Wideband and high-gain frequency stabilization of a 100-W injection-locked Nd:YAG laser for second-generation gravitational wave detectors.

    Science.gov (United States)

    Ohmae, Noriaki; Moriwaki, Shigenori; Mio, Norikatsu

    2010-07-01

    Second-generation gravitational wave detectors require a highly stable laser with an output power greater than 100 W to attain their target sensitivity. We have developed a frequency stabilization system for a 100-W injection-locked Nd:YAG (yttrium aluminum garnet) laser. By placing an external wideband electro-optic modulator used as a fast-frequency actuator in the optical path of the slave output, we can circumvent a phase delay in the frequency control loop originating from the pole of an injection-locked slave cavity. Thus, we have developed an electro-optic modulator made of a MgO-doped stoichiometric LiNbO(3) crystal. Using this modulator, we achieve a frequency control bandwidth of 800 kHz and a control gain of 180 dB at 1 kHz. These values satisfy the requirement for a laser frequency control loop in second-generation gravitational wave detectors.

  1. NKCC2 activity is inhibited by the Bartter's syndrome type 5 gain-of-function CaR-A843E mutant in renal cells.

    Science.gov (United States)

    Carmosino, Monica; Gerbino, Andrea; Hendy, Geoffrey N; Torretta, Silvia; Rizzo, Federica; Debellis, Lucantonio; Procino, Giuseppe; Svelto, Maria

    2015-04-01

    The gain-of-function A843E mutation of the calcium sensing receptor (CaR) causes Bartter syndrome type 5. Patients carrying this CaR variant show a remarkably reduced renal NaCl reabsorption in the thick ascending limb (TAL) of Henle's loop resulting in renal loss of NaCl in the absence of mutations in renal Na(+) and Cl(-) ion transporters. The molecular mechanisms underlying this clinical phenotype are incompletely understood. We investigated, in human embryonic kidney 293 (HEK 293) cells and porcine kidney epithelial (LLC-PK1) cells, the functional cross-talk of CaR-A843E with the Na(+):K(+):2Cl(-) co-transporter, NKCC2, which provides NaCl reabsorption in the TAL. The expression of the CaR mutant did not alter the apical localisation of NKCC2 in LLC-PK1 cells. However, the steady-state NKCC2 phosphorylation and activity were decreased in cells transfected with CaR-A843E compared with the control wild-type CaR (CaR WT)-transfected cells. Of note, low-Cl(-)-dependent NKCC2 activation was also strongly inhibited upon the expression of CaR-A843E mutant. The use of either P450 ω-hydroxylase (CYP4)- or phospholipase A2 (PLA2)-blockers suggests that this effect is likely mediated by arachidonic acid (AA) metabolites. The data suggested that the activated CaR affects intracellular pathways modulating NKCC2 activity rather than NKCC2 intracellular trafficking in renal cells, and throw further light on the pathological role played by active CaR mutants in Bartter syndrome type 5. © 2015 Société Française des Microscopies and Société de Biologie Cellulaire de France. Published by John Wiley & Sons Ltd.

  2. Gain-of-function mutations in the Toll-like Receptor pathway: TPL2-mediated ERK1/ERK2 MAPK activation, a path to tumorigenesis in lymphoid neoplasms?

    Directory of Open Access Journals (Sweden)

    Simon eRousseau

    2016-05-01

    Full Text Available Lymphoid neoplasms form a family of cancers affecting B-cells, T-cells and NK cells. The Toll-Like Receptor (TLR signalling adapter molecule MYD88 is the most frequently mutated gene in these neoplasms. This signalling adaptor relays signals from TLRs to downstream effector pathways such as the Nuclear Factor kappa B (NFB and Mitogen Activated Protein Kinase (MAPK pathways to regulate innate immune responses (Kawai and Akira, 2010. Gain-of-function mutations such as MYD88[L265P] activate downstream signalling pathways in absence of cognate ligands for TLRs, resulting in increased cellular proliferation and survival. This article reports an analysis of non-synonymous somatic mutations found in the TLR signaling network in lymphoid neoplasms. In accordance with previous reports, mutations map to MYD88 pro-inflammatory signaling and not TRIF-mediated Type I IFN production. Interestingly, the analysis of somatic mutations found downstream of the core TLR-signaling network uncovered a strong association with the ERK1/2 MAPK cascade. In support of this analysis, heterologous expression of MYD88[L265P] in HEK 293 cells led to ERK1/2 MAPK phosphorylation in addition to NFB activation. Moreover, this activation is dependent on the protein kinase Tumour Promoting Locus-2 (TPL-2, activated downstream of the IKK complex. Activation of ERK1/2 would then lead to activation, amongst others, of MYC and hnRNP A1, two proteins previously shown to contribute to tumour formation in lymphoid neoplasms. Taken together, this analysis suggests that TLR-mediated tumorigenesis occurs via the TPL2-mediated ERK1/2 activation. Therefore, the hypothesis proposed is that inhibition of ERK1/2 MAPK activation would prevent tumour growth downstream of MYD88[L265]. It will be interesting to test whether pharmacological inhibitors of this pathway show efficacy in primary tumour cells derived from hematologic malignancies such as Waldenstrom’s Macroglobulinemia, where the

  3. ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function

    Directory of Open Access Journals (Sweden)

    Lia Zepa

    2011-01-01

    Full Text Available Activating the amyloid cascade by inhibiting the Aβ-degrading enzyme neprilysin in targeted replacement mice, which express either apoE4 or apoE3, results in the specific accumulation of oligomerized Aβ42 in hippocampal CA1 neurons of the apoE4 mice. We presently investigated the extent to which the apoE4-driven accumulation of Aβ42 and the resulting mitochondrial pathology are due to either gain or loss of function. This revealed that inhibition of neprilysin for one week triggers the accumulation of Aβ42 in hippocampal CA1 neurons of the apoE4 mice but not of either the corresponding apoE3 mice or apoE-deficient mice. At 10 days, Aβ42 also accumulated in the CA1 neurons of the apoE-deficient mice but not in those of the apoE3 mice. Mitochondrial pathology, which in the apoE4 mice is an early pathological consequence following inhibition of neprilyisn, also occurs in the apoE-deficient but not in the apoE3 mice and the magnitude of this effect correlates with the levels of accumulated Aβ42 and oligomerized Aβ42 in these mice. These findings suggest that the rate-limiting step in the pathological effects of apoE4 on CA1 neurons is the accumulation of intracellular oligomerized Aβ42 which is mediated via a gain of function property of apoE4.

  4. High-activity liquid packaging design criteria

    Energy Technology Data Exchange (ETDEWEB)

    1994-05-01

    In recent studies, it has been acknowledged that there is an emerging need for packaging to transport high-activity liquid off the Hanford Site to support characterization and process development activities of liquid waste stored in underground tanks. These studies have dealt with specimen testing needs primarily at the Hanford Site; however, similar needs appear to be developing at other US Department of Energy (DOE) sites. The need to ship single and multiple specimens to offsite laboratories is anticipated because it is predicted that onsite laboratories will be overwhelmed by an increasing number and size (volume) of samples. Potentially, the specimen size could range from 250 mL to greater than 50 L. Presently, no certified Type-B packagings are available for transport of high-activity liquid radioactive specimens in sizes to support Site missions.

  5. Change, Gain and Loss

    Institute of Scientific and Technical Information of China (English)

    Fu Mengzi

    2006-01-01

    @@ Five years have passed since the September 11 terrorist attacks occurred. America's counter-terrorism campaign is still on the way.Besides the momentary monumental significance of the fifth anniversary, five years is still too short in regard to the long-term counter-terrorism campaign. Yet, America's president's tenure is eight years at best; most of Bush's presidency time has passed. Five years ago, the U. S. encountered the most serious terrorist attack; the whole nation formed a consensus that counter-terrorism is its utmost priority. President Bush once enjoyed a support rate as high as 90% for over 16 months. But five years later, the trend changes. People can not help but ask: what are the gains and losses of the Republican Party in dealing with national security affairs?

  6. High activity carbon sorbents for mercury capture

    Energy Technology Data Exchange (ETDEWEB)

    George G. Stavropoulos; Irene S. Diamantopoulou; George E. Skodras; George P. Sakellaropoulos [Aristotle University of Thessaloniki, Thessaloniki (Greece). Chemical Process Engineering Laboratory

    2006-07-01

    High efficiency activated carbons have been prepared for removing mercury from gas streams. Starting materials used were petroleum coke, lignite, charcoal and olive seed waste, and were chemically activated with KOH. Produced adsorbents were primarily characterized for their porosity by N{sub 2} adsorption at 77K. Their mercury retention capacity was characterized based on the breakthrough curves. Compared with typical commercial carbons, they have exhibited considerably enhanced mercury adsorption capacity. An attempt has been made to correlate mercury entrapment and pore structure. It has been shown that physical surface area is increased during activation in contrast to the mercury adsorption capacity that initially increases and tends to decrease at latter stages. Desorption of active sites may be responsible for this behavior. 10 refs., 3 figs., 1 tab.

  7. Achieving high-resolution soft-tissue imaging with cone-beam CT: a two-pronged approach for modulation of x-ray fluence and detector gain

    Science.gov (United States)

    Graham, S. A.; Siewerdsen, J. H.; Moseley, D. J.; Keller, H.; Shkumat, N. A.; Jaffray, D. A.

    2005-04-01

    Cone-beam computed tomography (CBCT) presents a highly promising and challenging advanced application of flat-panel detectors (FPDs). The great advantage of this adaptable technology is in the potential for sub-mm 3D spatial resolution in combination with soft-tissue detectability. While the former is achieved naturally by CBCT systems incorporating modern FPD designs (e.g., 200 - 400 um pixel pitch), the latter presents a significant challenge due to limitations in FPD dynamic range, large field of view, and elevated levels of x-ray scatter in typical CBCT configurations. We are investigating a two-pronged strategy to maximizing soft-tissue detectability in CBCT: 1) front-end solutions, including novel beam modulation designs (viz., spatially varying compensators) that alleviate detector dynamic range requirements, reduce x-ray scatter, and better distribute imaging dose in a manner suited to soft-tissue visualization throughout the field of view; and 2) back-end solutions, including implementation of an advanced FPD design (Varian PaxScan 4030CB) that features dual-gain and dynamic gain switching that effectively extends detector dynamic range to 18 bits. These strategies are explored quantitatively on CBCT imaging platforms developed in our laboratory, including a dedicated CBCT bench and a mobile isocentric C-arm (Siemens PowerMobil). Pre-clinical evaluation of improved soft-tissue visibility was carried out in phantom and patient imaging with the C-arm device. Incorporation of these strategies begin to reveal the full potential of CBCT for soft-tissue visualization, an essential step in realizing broad utility of this adaptable technology for diagnostic and image-guided procedures.

  8. Weight gain induced by an isocaloric pair-fed high fat diet: a nutriepigenetic study on FASN and NDUFB6 gene promoters.

    Science.gov (United States)

    Lomba, Almudena; Martínez, J Alfredo; García-Díaz, Diego F; Paternain, Laura; Marti, Amelia; Campión, Javier; Milagro, Fermín I

    2010-01-01

    Experimental studies have demonstrated that dietary macronutrient distribution plays an important role in insulin regulation, a risk factor associated to obesity, diabetes and other metabolic disorders. To assess whether the macronutrient composition of the diet could be related to obesity onset by affecting the epigenetic regulation of gene expression, we investigated in rats the metabolic effects of two pair-fed isocaloric diets: control (rich in carbohydrates) and high fat diet (rich in fat; HFD). Compared to controls, HFD induced higher weight gain and adiposity and impaired glucose tolerance, which was accompanied by a slight increase in adiponectin levels and liver steatosis. Epididymal adipose tissue expression of the fatty acid synthase (FASN) gene and NADH dehydrogenase (ubiquinone) 1β-subcomplex 6 (NDUFB6) were significantly reduced in HFD group. These variations in mRNA levels were accompanied by changes in the methylation patterns of several CpG islands located in the promoter region of these genes. However, no correlations were found between gene expression and the methylation status. These results suggest that high fat intake produces overweighted rats independently of total energy intake. These diets could also induce some epigenetic changes in the promoters of key genes that could influence gene expression and may be behind metabolic alterations.

  9. Activity-based Costing (ABC and Activity-based Management(ABMImplementation – Is This the Solution for Organizations to Gain Profitability?

    Directory of Open Access Journals (Sweden)

    Ildikó Réka CARDOS

    2011-06-01

    Full Text Available Adherents of ABC/ABM systems claimed traditional management accounting systems generated misleading costs in a contemporary, tumultuous, often changing business environment and implementing ABC/ABM would remedy this. That is why activity-based costing (ABC and activity-based management (ABM represents the symbol of improved competitiveness and efficiency in every organization.The purpose of this article – after analyzing the existing literature in the field – is to emphasize that new cost systems such as ABC and ABM could be a strong couple that assures competitiveness and efficiency for each company. Another objective is to present that, besides its disadvantages, firms implement the ABC/ABM system because it permits better tracing of costs to objects, superior allocation of overheads to cost objects, financial and non-financial analysis and measures useful to managers and management accountants in the decision-making process.

  10. A high multivitamin diet fed to Wistar rat dams during pregnancy increases maternal weight gain later in life and alters homeostatic, hedonic and peripheral regulatory systems of energy balance.

    Science.gov (United States)

    Pannia, Emanuela; Cho, Clara E; Kubant, Ruslan; Sánchez-Hernández, Diana; Huot, Pedro S P; Chatterjee, Diptendu; Fleming, Alison; Anderson, G Harvey

    2015-02-01

    High multivitamin (10-fold, HV) and high folic acid (Fol) diets fed to pregnant Wistar rats increase body weight and characteristics of the metabolic syndrome in their offspring. Our objective was to determine the effects of a HV maternal diet on dams and whether methyl vitamins contribute to these effects. Pregnant Wistar rats were fed AIN-93G diets containing either (1) recommended multivitamins (RV, control), (2) HV, (3) HV with recommended Fol (HVRF; 1-fold Fol), or (4) RV with high methyl group vitamins (HMethyl; 10-fold Fol, vitamin B12 and B6). All groups were fed a RV diet during lactation until weaning and a RV high fat (HF; 60% fat) diet for 16 weeks post-weaning. The HV, HVRF and HMethyl diet fed dams gained 45% more weight from 2 to 15 weeks post-weaning and their weight gain (WG) was positively associated with cumulative post-weaning food intake (FI). However, only HV dams had a reduced preference for a sucrose solution, lower mesolimbic dopamine (DA) turnover in the nucleus accumbens (NAc), and higher expression of several genes involved in FI regulation in the arcuate nucleus of the hypothalamus (ARC). Energy conserving peroxisome proliferator-activated receptor (Ppar)-γ in adipose and -α in liver was also greater in these dams consistent with their WG. In conclusion, HV, HVRF and HMethyl maternal diets exacerbate maternal WG when dams are exposed to a HF diet post-weaning. However, the diets differed in their effects on central and peripheral regulatory systems of energy balance. Copyright © 2014 Elsevier B.V. All rights reserved.

  11. Production of high specific activity silicon-32

    Energy Technology Data Exchange (ETDEWEB)

    Phillips, D.R. [Los Alamos National Lab., NM (United States); Brzezinski, M.A. [Univ. of California, Santa Barbara, CA (United States). Marine Biotechnology Center

    1998-12-31

    This is the final report of a three-year, Laboratory Directed Research and Development Project (LDRD) at Los Alamos National Laboratory (LANL). There were two primary objectives for the work performed under this project. The first was to take advantage of capabilities and facilities at Los Alamos to produce the radionuclide {sup 32}Si in unusually high specific activity. The second was to combine the radioanalytical expertise at Los Alamos with the expertise at the University of California to develop methods for the application of {sup 32}Si in biological oceanographic research related to global climate modeling. The first objective was met by developing targetry for proton spallation production of {sup 32}Si in KCl targets and chemistry for its recovery in very high specific activity. The second objective was met by developing a validated field-useable, radioanalytical technique, based upon gas-flow proportional counting, to measure the dynamics of silicon uptake by naturally occurring diatoms.

  12. Active vibration isolation of high precision machines

    CERN Document Server

    Collette, C; Artoos, K; Hauviller, C

    2010-01-01

    This paper provides a review of active control strategies used to isolate high precisionmachines (e.g. telescopes, particle colliders, interferometers, lithography machines or atomic force microscopes) from external disturbances. The objective of this review is to provide tools to develop the best strategy for a given application. Firstly, the main strategies are presented and compared, using single degree of freedom models. Secondly, the case of huge structures constituted of a large number of elements, like particle colliders or segmented telescopes, is considered.

  13. Digital automatic gain control

    Science.gov (United States)

    Uzdy, Z.

    1980-01-01

    Performance analysis, used to evaluated fitness of several circuits to digital automatic gain control (AGC), indicates that digital integrator employing coherent amplitude detector (CAD) is best device suited for application. Circuit reduces gain error to half that of conventional analog AGC while making it possible to automatically modify response of receiver to match incoming signal conditions.

  14. Comparing gains and losses.

    Science.gov (United States)

    McGraw, A Peter; Larsen, Jeff T; Kahneman, Daniel; Schkade, David

    2010-10-01

    Loss aversion in choice is commonly assumed to arise from the anticipation that losses have a greater effect on feelings than gains, but evidence for this assumption in research on judged feelings is mixed. We argue that loss aversion is present in judged feelings when people compare gains and losses and assess them on a common scale. But many situations in which people judge and express their feelings lack these features. When judging their feelings about an outcome, people naturally consider a context of similar outcomes for comparison (e.g., they consider losses against other losses). This process permits gains and losses to be normed separately and produces psychological scale units that may not be the same in size or meaning for gains and losses. Our experiments show loss aversion in judged feelings for tasks that encourage gain-loss comparisons, but not tasks that discourage them, particularly those using bipolar scales.

  15. X-ray Production by Cascading Stages of a High-Gain Harmonic Generation Free-Electron Laser II: Special Topics

    Energy Technology Data Exchange (ETDEWEB)

    Wu, J

    2004-09-01

    In this paper, we study the tolerance of a new approach to produce coherent x-ray by cascading several stages of a High-Gain Harmonic Generation (HGHG) Free-Electron Laser (FEL). Being a harmonic generation process, a small noise in the initial fundamental signal will lead to a significant noise-to-signal (NTS) ratio in the final harmonic, so the noise issue is studied in this paper. We study two sources of noise: the incoherent undulator radiation, which is a noise with respect to the seed laser; and the noise of the seed laser itself. In reality, the electron beam longitudinal current profile is not uniform. Since the electron beam is the amplification medium for the FEL, this non- uniformity will induce phase error in the FEL. Therefore, this effect is studied. Phase error due to the wakefield and electron beam self-field is also studied. Synchrotronization of the electron beam and the seed laser is an important issue determining the success of the HGHG. We study the timing jitter induced frequency jitter in this paper. We also show that an HGHG FEL poses a less stringent requirement on the emittance than a SASE FEL does, due to a Natural Emittance Effect Reduction (NEER) mechanism. This NEER mechanism suggests a new operation mode, i.e., the HGHG FEL could adopt a high current, though unavoidable, a high emittance electron beam. Study in this paper shows that, production of hard x-rays with good longitudinal coherence by cascading stages of a HGHG FEL is promising. However, technical improvement is demanded.

  16. Chrysobalanus icaco L. Leaves Normalizes Insulin Sensitivity and Blood Glucose and Inhibits Weight Gain in High-Fat Diet-Induced Obese Mice.

    Science.gov (United States)

    White, Pollyanna A S; Araújo, Jessica M D; Cercato, Luana M; Souza, Lucas A; Barbosa, Ana Paula Oliveira; Quintans-Junior, Lucindo José; Machado, Ubiratan F; Camargo, Enilton A; Brito, Luciana C; Santos, Marcio Roberto V

    2016-02-01

    Chrysobalanus icaco L. is a medicinal plant present in the Brazilian coastline and known for its hypoglicemic and antioxidant properties. Here, we assessed the beneficial metabolic effects of the aqueous extract of C. icaco (AECI) leaves in diet-induced obese mice. Swiss mice were fed standard chow (SC used as controls) or high-fat diet (HFD) to induce obesity. After 10 weeks, mice on each diet were divided into two groups with one group used as control while the other group treated with AECI for 4 weeks resulting in four groups of mice: SC; SC treated with AECI (SC + AECI); HFD; and HFD treated with AECI (HFD + AECI). AECI was administered drinking water at about 200 mg/kg. AECI was able to normalize insulin (13,682 ± 1090 vs. 9828 ± 485 AU, P fat storage in liver (72.60 ± 3.83%, P fat intake. These findings reinforce the use of AECI in hyperglycemia and highlight the potential extract's effect in preventing weight gain and fat accumulation in liver of diet-induced obese mice.

  17. Rice koji reduced body weight gain, fat accumulation, and blood glucose level in high-fat diet-induced obese mice

    Directory of Open Access Journals (Sweden)

    Yumiko Yoshizaki

    2014-08-01

    Full Text Available Rice koji is considered a readily accessible functional food that may have health-promoting effects. We investigated whether white, yellow, and red koji have the anti-obesity effect in C57BL/6J mice fed a high-fat diet (HFD, which is a model for obesity. Mice were fed HFD containing 10% (w/w of rice koji powder or steamed rice for 4 weeks. Weight gain, epididymal white adipose tissue, and total adipose tissue weight were significantly lower in all rice koji groups than in the HFD-rice group after 4 weeks. Feed efficiency was significantly reduced in the yellow koji group. Blood glucose levels were significantly lower in the white and red koji groups with HOMA-R and leptin levels being reduced in the white koji group. White and red koji increased glucose uptake and GLUT4 protein expression in L6 myotube cells. These results showed that all rice koji have the anti-obesity or anti-diabetes effects although the mechanisms may differ depending on the type of rice koji consumed.

  18. The effect of a county's public high school summer remediation program on student gains on end-of-course standard of learning tests in Algebra I, Biology, Chemistry, Geometry and World History and Geography II

    Science.gov (United States)

    Aiken, Brenda L.

    The Commonwealth of Virginia requires high school students to receive a passing grade in core courses and a passing score on End-of-Course Standards of Learning (EOC SOL) tests to receive verified credits that lead to a Virginia high school diploma. These tests are believed to accurately reflect what students should know and be able to do in order to experience success in their endeavors beyond high school. For some students remediation is required to experience success on EOC SOL tests. This study sought to determine the effect of a County's public high school summer remediation program on student gains on EOC SOL tests in Algebra I, Biology, Chemistry, Geometry, and World History and Geography II. Specifically, the purpose of the study sought to determine the following: (a) If significant gains were made by students who attended the summer remediation program; (b) If significant gains were made by students who did not attend the summer remediation program; (c) If there were differences in gain scores of students who attended and those who did not attend the summer remediation program; and (d) If there were differences in gain scores among students who attended the summer remediation program related to school site, gender, ethnicity, learning ability group, socioeconomic status, and level of English proficiency. The results of the study indicate that students who attended and those who did not attend the summer remediation program made significant gains. However, the gains for students who attended the summer remediation program were significantly greater than the gains made by students who did not attend. The study also found that there were no significant differences in gain scores among students who attended the summer remediation program related to gender, ethnicity, learning ability group, socioeconomic status, and level of English proficiency. There were significant differences in Algebra I gain scores related to school site. Recommendations for

  19. Unity gain and non-unity gain quantum teleportation

    CERN Document Server

    Bowen, W P; Buchler, B C; Schnabel, R; Ralph, T C; Symul, T; Lam, P K

    2003-01-01

    We investigate continuous variable quantum teleportation. We discuss the methods presently used to characterize teleportation in this regime, and propose an extension of the measures proposed by Grangier and Grosshans \\cite{Grangier00}, and Ralph and Lam \\cite{Ralph98}. This new measure, the gain normalized conditional variance product $\\mathcal{M}$, turns out to be highly significant for continuous variable entanglement swapping procedures, which we examine using a necessary and sufficient criterion for entanglement. We elaborate on our recent experimental continuous variable quantum teleportation results \\cite{Bowen03}, demonstrating success over a wide range of teleportation gains. We analyze our results using fidelity; signal transfer, and the conditional variance product; and a measure derived in this paper, the gain normalized conditional variance product.

  20. High Energy Activation Data Library (HEAD-2009)

    CERN Document Server

    Korovin, Yury A; Konobeyev, Alexander Yu; Stankovskiy, Alexey Yu; Mashnik, Stepan G

    2010-01-01

    A proton activation data library for 682 nuclides from 1-H to 210-Po in the energy range from 150 MeV up to 1 GeV was developed. To calculate proton activation data, the MCNPX 2.6.0 and CASCADE/INPE codes were chosen. Different intranuclear cascade, preequilibrium, and equilibrium nuclear reaction models and their combinations were used. The optimum calculation models have been chosen on the basis of statistical correlations for calculated and experimental proton data taken from the EXFOR library of experimental nuclear data. All the data are written in ENDF-6 format. The library is called HEPAD-2008 (High-Energy Proton Activation Data). A revision of IEAF-2005 neutron activation data library has been performed: A set of nuclides for which the cross-section data can be (and were) updated using more modern and improved models is specified, and the corresponding calculations have been made in the present work. The new version of the library is called IEAF-2009. The HEPAD-2008 and IEAF-2009 are merged to the fin...